Oral cancer: 1. The genetic basis of the disease.
This article is in two parts. The first describes recent advances in our understanding of the biology of oral cancer and the potential to utilize this new information to make better predictions about outcome and devise new treatments. The second part describes the clinical presentation and the development of a new generation of ultra-sensitive diagnostics to identify occult tumour and precancer, to investigate why cancer may recur.
Partridge
M
M
Maxillofacial Unit/Oncology, King's College Hospital, Denmark Hill, London.
D017209:Apoptosis / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D005784:Gene Amplification / Q000235:genetics; D015321:Gene Rearrangement / Q000235:genetics; D016147:Genes, Tumor Suppressor / Q000235:genetics; D015316:Genetic Therapy; D006801:Humans; D009062:Mouth Neoplasms / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D009154:Mutation / Q000235:genetics; D009857:Oncogenes / Q000235:genetics; D009858:Oncogenic Viruses / Q000235:genetics; D011379:Prognosis; D019098:Telomerase / Q000235:genetics
D019098:Telomerase