title: Irinotecan and cisplatin in advanced gastric or gastroesophageal junction carcinoma.
abstract: Chemotherapy for advanced gastric and gastroesophageal junction carcinomas remains suboptimal. Both irinotecan (Camptosar) and cisplatin (Platinol) are active against this group of malignancies. This article focuses on the results of an ongoing phase II trial with this combination in patients with advanced gastric or gastroesophageal junction carcinoma. Data from this trial suggest that the combination of irinotecan and cisplatin is active in untreated as well as previously treated patients with gastric or gastroesophageal junction carcinoma.
authors.affiliation: Department of Gastrointestinal Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Ajani
authors.forename: J
authors.initials: J
authors.lastname: Fairweather
authors.forename: P W
authors.initials: PW
authors.lastname: Pisters
authors.forename: C
authors.initials: C
authors.lastname: Charnsangavej
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D002945:Cisplatin / Q000008:administration & dosage; D017322:Clinical Trials, Phase II as Topic; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004943:Esophagogastric Junction; D006801:Humans; D000077146:Irinotecan; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
chemical_list: D000077146:Irinotecan; D002945:Cisplatin; D002166:Camptothecin