title: IgA nephropathy with complement deficiency.
abstract: We treated a female patient suffering from immunoglobulin A (IgA) nephropathy and congenital deficiency of the ninth component of the complement system (C9). She was admitted with hematuria and proteinuria, and the C9 deficiency was diagnosed based on the low hemolytic activity of 50 % of the hemolytic unit of the complements (CH50) and the normal C3 level in the plasma. Renal biopsy revealed mild mesangial proliferation, and immunofluorescence examination revealed mild mesangial deposits of IgA and C3 with the same distribution. We discuss the pathogenesis of IgA nephropathy and the role of the complements in its progression.
authors.affiliation: Department of Internal Medicine, Tokyo Medical and Dental University School of Medicine.
authors.forename: E
authors.initials: E
authors.lastname: Kanda
authors.forename: H
authors.initials: H
authors.lastname: Shimamura
authors.forename: H
authors.initials: H
authors.lastname: Tamura
authors.forename: S
authors.initials: S
authors.lastname: Uchida
authors.forename: Y
authors.initials: Y
authors.lastname: Terada
authors.forename: H
authors.initials: H
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Kuwabara
authors.forename: T
authors.initials: T
authors.lastname: Akiba
authors.forename: T
authors.initials: T
authors.lastname: Ida
authors.forename: S
authors.initials: S
authors.lastname: Sasaki
authors.forename: F
authors.initials: F
authors.lastname: Marumo
mesh_terms: D000328:Adult; D003165:Complement System Proteins / Q000172:deficiency*; D005260:Female; D005920:Glomerular Mesangium / Q000737:chemistry / Q000473:pathology; D005922:Glomerulonephritis, IGA / Q000097:blood / Q000150:complications* / Q000473:pathology; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D011507:Proteinuria / Q000209:etiology
chemical_list: D007070:Immunoglobulin A; D003165:Complement System Proteins