[Use of clofelin in the prevention of perioperative myocardial dysfunction in patients with ischemic heart disease].
The purpose of this study was to evaluate the possibility of using clofeline in anesthesiological protocol for myocardial revascularization as a drug preventing hemodynamic disorders and perioperative myocardial dysfunction. In group 1 (27 pts.) clofelin was used in premedication (150 micrograms at night on the eve of surgery and before the operation), group 2 (29 pts.) was control. Clofelin improved the stability of the cardiovascular system, decreased the incidence of hyperdynamic reactions, episodes of myocardial ischemia, and cardiac arrhythmia during surgery. Use of clofelin for premedication decreased the need in inotropic support during the postperfusion period from 49 to 37% and ensured a higher cardiac production during transfer from artificial to spontaneous circulation.
Iavorovskiĭ
A G
AG
Meshcheriakov
A V
AV
Grishin
V V
VV
Aksel'rod
B A
BA
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000787:Angina Pectoris / Q000150:complications; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003000:Clonidine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications*; D009204:Myocardial Revascularization; D011229:Preanesthetic Medication; D011300:Preoperative Care; D012307:Risk Factors; D013610:Tachycardia / Q000150:complications; D013997:Time Factors
D000316:Adrenergic alpha-Agonists; D000700:Analgesics; D000959:Antihypertensive Agents; D003000:Clonidine
Ispol'zovanie klofelina dlia profilaktiki perioperatsionnoĭ disfunktsii miokarda u bol'nykh IBS.