First evidence of a delay-dependent working memory-enhancing effect of modafinil in mice.
This study investigated the effects of pretest injection of modafinil on delayed spontaneous alternation rates (SA) used to evaluate working memory in C57 Bl/6 mice. In a first experiment, systemic modafinil at 64 mg/kg, but not at 8 mg/kg or 32 mg/kg doses produced a significant increase of alternation scores (intertrial interval (ITI) 60s) when compared with controls. In a second experiment, modafinil (64 mg/kg) enhanced the alternation rates mainly at long (60 s and 180 s) but not at short (5 s) ITIs. Exploratory latencies and activity in a four hole-board apparatus were not modified by modafinil administration. These experiments are the first to demonstrate a delay-dependent working memory-enhancing effect of modafinil.
Béracochéa
D
D
Laboratoire de Neurosciences Cognitives, Université de Bordeaux I, UMR CNRS 5601, Talence, France.
Cagnard
B
B
Célérier
A
A
le Merrer
J
J
Pérès
M
M
Piérard
C
C
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects; D005625:Frontal Lobe / Q000502:physiology; D006624:Hippocampus / Q000502:physiology; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D000077408:Modafinil
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D000077408:Modafinil