title: [Phytotherapeutic drugs and sleep].
abstract: Most of the studies about phythotherapeutics and sleep confirmed only hypnotic effects on subjective sleep variables. For LI 160, a hypericum extract, an induction of slow wave sleep was demonstrated in older volunteers. In patients with major depression (MD) an increase of slow wave sleep was observed by our group after a six week therapy with hypericum extract (LI 160) and after an adjunct therapy with Ginkgo biloba LI 1370 extract. In MD sleep disturbances and hypersecretion of glucocorticoids are common features. For LI 160 beneficial effects on depressed mood and for LI 1370 effects on cognitive functioning are well documented. The potential relationship between influence on sleep structure and the hypothalamic-pituitary-adrenal axis will be discussed within the neurophysiological-neuroendocrine "extended two process model" of sleep regulation.
authors.affiliation: Psychiatrische Universitätsklinik, Depressionsforschung, Schlafmedizin und Neurophysiologie, Basel.
authors.forename: E
authors.initials: E
authors.lastname: Holsboer-Trachsler
mesh_terms: D020441:Ginkgo biloba; D006801:Humans; D020902:Hypericum; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000627:therapeutic use*; D010936:Plant Extracts / Q000009:adverse effects / Q000627:therapeutic use*; D010946:Plants, Medicinal; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D012894:Sleep Stages / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D006993:Hypnotics and Sedatives; D010936:Plant Extracts
vernacular_title: Phytotherapeutika und Schlaf.