title: In vivo comparison of bioactive glass particles in rabbits.
abstract: Bioglass particles of the compositions 45s5, 52s and 55s were implanted in the distal femoral epiphysis of rabbits. Animals were sacrificed at 7, 28, and 84 d postoperatively and specimens investigated using light microscopy and histomorphometry. Bone bonding occurred in a zentripetal fashion and fastest for 45s5. Bone formation was hampered at the core of the implantation bed where bone bonding showed a peak at 28d and diminished at 84d (except for 55s). This went along with a significant increase in numerous multinuclear giant cells (MNGC). Implantation model, particle size and surface-area-to-volume ratio are discussed as possible parameters determining bone regeneration.
authors.affiliation: Department of Traumatology and Reconstructive Surgery, Universtitätsklinikum Benjamin Franklin, Freie Universität Berlin, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Vogel
authors.forename: C
authors.initials: C
authors.lastname: Voigt
authors.forename: U M
authors.initials: UM
authors.lastname: Gross
authors.forename: C M
authors.initials: CM
authors.lastname: Müller-Mai
mesh_terms: D000818:Animals; D005069:Evaluation Studies as Topic; D005260:Female; D005269:Femur / Q000033:anatomy & histology; D017102:Fracture Healing; D005898:Glass; D019736:Prostheses and Implants; D011817:Rabbits