[Evaluation of antibiotic preparations for children from a standpoint of water-solubilities].
The evaluation of seven widely-used antibiotic preparations [five cephem antibiotics; cefaclor (CCL), cefpodoxime proxetil (CPDX-PR), cefdinir (CFDN), cefditoren pivoxil (CDTR-PI), cefcapene pivoxil (CFPN-PI), one macrolide; clarithromycin (CAM) and one penem; faropenem sodium (FRPM)] for children were performed from a standpoint of water-solubilities, both as a preparation and as a component drug. As the results, these preparations showed great differences in the water-solubilities when added 10 ml water to 0.5 g of each preparation. That is, their solubilities differed from about 40% (CFPN-PI) to 100% (FRPM) as a preparation, and from nearly 0% (CAM) to 100% (FRPM, CCL) as a component drug. Additionally, about a half of the insoluble residues were found to be the component drug, in the cases of three preparations (CPDX-PX, CFDN, CDTR-PI) which were solubilized at 80-90%. From these results, it was suggested that the marketed antibiotic preparations for children might be classified into three categories; i.e., [A] preparation for solution and suspension (FRPM, CCL), [B] preparation suitable to suspension (CPDX-PR, CFDN, CDTR-PI), and [C] fine granule preparation for children unsuitable to suspension (CFPN-PI, CAM). Consequently, the names for dosage-forms of these preparations should be standardized.
Honda
Y
Y
Department of Pharmacy, Kumamoto University Hospital, Honjo 1-1-1, Kumamoto 860-8556, Japan.
Nakano
M
M
D000900:Anti-Bacterial Agents; D002648:Child; D002675:Child, Preschool; D004304:Dosage Forms / Q000592:standards*; D006801:Humans; D007223:Infant; D012995:Solubility; D014867:Water
D000900:Anti-Bacterial Agents; D004304:Dosage Forms; D014867:Water