Change of coagulation factor VIII and antithrombin III activity in bank-stored blood.
Coagulation factor VIII and antithrombin III activity were detected in 15 health donors. It was found that antithrombin III activity decreased obviously 12 h after blood drawing. It lost 56% of the activity at the 3rd day, and 70% of the activity at the 7th day. FVIII:c showed no obvious change after 24 h, until the 3rd day. It lost 40%-60% of the activity after 36 h and was reduced to the 30% of the original activity at the 5th day. Our results suggested that at the 3rd day coagulation factor VIII of bank-stored blood can be used to replenish antithrombin III, while bank-stored blood in one day can be used to replenish F VIII.
Hu
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L
Blood Transfusion Department, Xiehe Hospital, Tongji Medical University, Wuhan 430022.
Yu
Z
Z
Zhang
Q
Q
D000293:Adolescent; D000328:Adult; D000990:Antithrombin III / Q000378:metabolism*; D001771:Blood Banks; D001793:Blood Preservation; D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D000990:Antithrombin III; D005169:Factor VIII