Bone grafting the jaws in the 21st century: the use of platelet-rich plasma and bone morphogenetic protein.
The use of PRP and rhBMP-2 in facial skeletal reconstruction is supported by theoretical and practical human and animal data that represent exciting prospects for the 21st century. Although the use of PRP in conjunction with autogenous grafting of the maxillofacial complex increases the already impressive predictability of this technique, it is possible that improvement of the clinical use of rhBMP-2 may one day obviate the need for a donor site harvest of bone.
Carlson
E R
ER
Division of Oral and Maxillofacial Surgery, University of Miami, School of Medicine, USA.
D000818:Animals; D001792:Blood Platelets / Q000737:chemistry; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage / Q000494:pharmacology; D001861:Bone Regeneration / Q000187:drug effects; D016025:Bone Transplantation / Q000379:methods*; D006133:Growth Substances / Q000008:administration & dosage*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage; D056948:Orthognathic Surgical Procedures; D017713:Platelet Transfusion; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage; D011994:Recombinant Proteins / Q000008:administration & dosage; D016212:Transforming Growth Factor beta / Q000008:administration & dosage
C525718:BMP2 protein, human; D055396:Bone Morphogenetic Protein 2; D019485:Bone Morphogenetic Proteins; D006133:Growth Substances; D010982:Platelet-Derived Growth Factor; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; C499469:recombinant human bone morphogenetic protein-2; D007334:Insulin-Like Growth Factor I