[Structural characteristics of the adrenal cortex from rats with stress-induced hereditary arterial hypertension in the late postnatal ontogenesis].
The comparative investigation of the adrenal cortex in hypertensive (INHERITED STRESS-INDUCED ARTERIAL HYPERTENSION--ISIAH) and normotensive strain (Wistar) 12-months age rats was performed. The structural signs such as the lowering of the mitochondria volume involved in steroid synthesis in showed more notable age-related reduction of steroidogenesis in the adrenal glomerular and fascicular zones and in the ISIAH rats. The lowering of the cell steroidogenesis was compensated by the adrenal glomerular and fascicular zones and hypertrophy as a result the adrenocorticocytes hyperplasia. At the same time the more considerable sclerotic changes of the adrenal cortex periendothelial space were demonstrated in the ISIAH rats. The results obtained give evidence that reducing potential of compensatory possibilities of the adrenal cortex of the ISIAH rats in the late postnatal ontogenesis period cause high probability of adaptative-compensatory mechanisms failure and pathological process aggravation in these animals.
Buzueva
I I
II
Laboratory of Electron Microscopy and Pathophysiology, Institute of Physiology, Siberian Section of Russian Academy of Medical Sciences, Novosibirsk.
Shmerling
M D
MD
Filiushina
E E
EE
Markel'
A L
AL
Iakobson
G S
GS
D000302:Adrenal Cortex / Q000473:pathology* / Q000648:ultrastructure; D000818:Animals; D006973:Hypertension / Q000235:genetics / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000150:complications*
Strukturnaia kharakteristika kory nadpochechnika krys s nasledstvennoĭ indutsirovannoĭ stressom arterial'noĭ hypertenzieĭ v pozdnem periode postnatal'nogo ontogeneza.