Polyphenolic compounds from Geranium pratense and their free radical scavenging activities.
Two new polyphenolic compounds, myricetin 3-O-(2"-O-galloyl)-beta-D-glucopyranoside and (-)-6-chloroepicatechin, were isolated from the aerial parts of Geranium pratense subsp. finitimum (Woronow) Knuth, along with three known polyphenolic compounds [quercetin 3-O-(2"-O-galloyl)-beta-D-glucopyranoside, quercetin 3-O-(2"-O-galloyl)-beta-D-galactopyranoside, methyl gallate] and tryptophan. Quercetin 3-O-beta-D-glucopyranoside, quercetin 3-O-beta-D-galactopyranoside, quercetin 3-O-(2"-O-galloyl)-beta-D-glucopyranoside and quercetin 3-O-(2"-O-galloyl)-beta-D-galactopyranoside were found to be effective against free radical induced impairment of endothelium-dependent relaxation in isolated rat aorta.
Akdemir
Z S
ZS
Department of Pharmacognosy, Faculty of Pharmacy, Hacettepe University, Sihhiye, Ankara, Turkey. zakdemir@hacettepe.edu.tr
Tatli
I I
II
Saracoğlu
I
I
Ismailoğlu
U B
UB
Sahin-Erdemli
I
I
Caliş
I
I
D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000502:physiology; D016166:Free Radical Scavengers / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D015394:Molecular Structure; D009126:Muscle Relaxation / Q000187:drug effects; D051381:Rats; D019685:Rosales / Q000737:chemistry*; D013057:Spectrum Analysis
C424890:6-chloroepicatechin; D016166:Free Radical Scavengers; D006027:Glycosides; C424889:myricetin 3-O-(2''-O-galloyl)-beta-D-glucopyranoside; D002392:Catechin