[Effect of growth hormone and other hormones on trabecular bone structure in acromegaly].
The influence of growth hormone upon trabecular bone remodelation is not definitely clear. The authors of this study compared static and dynamic histomorphometric data of bone patterns of 28 numbered group of acromegalics and 35 numbered group of healthy individuals. They correlated also levels of growth hormone, thyroxine, prolactin and testosterone in men with histomorphometric parameters in acromegalic patients. The results showed statistically significant differences between normal and acromegalic trabecular bone, which has comparable trabecular volume, but significantly wider bone trabeculae and lower mean trabecular density. There were no correlations found between growth hormone levels and levels of thyroxine, prolactin, measured testosterone and histomorphometric parameters.
Zák
J
J
III. interní klinika, lékarské fakulty Univerzity Karlovy, U nemocnice 1, 128 08 Praha 2, Czech Republic.
Kapitola
J
J
Povýsil
C
C
Haas
T
T
D000172:Acromegaly / Q000097:blood / Q000473:pathology*; D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000473:pathology*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood; D013974:Thyroxine / Q000097:blood
D006728:Hormones; D013739:Testosterone; D011388:Prolactin; D013006:Growth Hormone; D013974:Thyroxine
Vliv růstového a nĕkterých dalsích hormonů na strukturu trámcité kosti akromegaliků.