[Production of immune mediators, induced by Lassa virus, in a human mononuclear cell culture].
Infection of human mononuclear cells with Lassa virus leads to production of inflammatory cytokines (tumor necrosis factor and interleukin-1). These cytokines cause expression of adhesion receptors ICAM-1 and VCAM-1 by human endothelial cells. Mitogen-induced cell proliferation was not suppressed 1 h after infection of human mononuclear cells with Lassa virus in a dose of 0.01 PFU/cell. The capacity of cells to proliferation in response to mitogen stimulation decreased significantly only 4 h after infection.
Ignat'ev
G M
GM
Strel'tsova
M A
MA
Otrashevskaia
E V
EV
D002455:Cell Division / Q000276:immunology; D002478:Cells, Cultured; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D007375:Interleukin-1 / Q000276:immunology; D007836:Lassa virus / Q000276:immunology*; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism / Q000821:virology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D019010:Vascular Cell Adhesion Molecule-1 / Q000378:metabolism
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1
Produktsiia mediatorov immuniteta v kul'ture chelovecheskikh mononuklearov, indutsirovannaia virusom Lassa.