title: Investigation of the threshold for allergic reactivity to chromium.
abstract: Allergy to chromium is relatively common, often in association with exposure to cement or in leather manufacture. However, in certain locations, there appears to be a relatively large cohort of chromium-sensitive individuals whose allergy cannot be explained by these common sources. In particular, this group include Israeli housewives with persistent hand eczema and concomitant patch test positivity to chromium. The causation of their allergy has been linked with relatively high levels of chromium contamination in household products. To provide further information in respect of the definition of safe levels for such products, we examined 17 chromium-allergic individuals to determine their threshold for reaction under closed patch test and repeated open application test (ROAT) conditions. The data derived indicated that, on normal skin, the patch test threshold was 10 ppm chromium; in the presence of an irritant (sodium lauryl sulfate) the threshold was closer to 1 ppm, 2/17 subjects giving 1+ reactions at this concentration. In the more realistic exposure conditions of the ROAT, 8/14 individuals failed to react to 50 ppm, whilst 3/15 reacted to 5 ppm. Interestingly, there was very poor correlation between patch test sensitivity and ROAT sensitivity. To ensure the large majority of chromium-allergic individuals do not suffer elicitation of their allergy, as well as to limit the development of new chromium-sensitive subjects, it is recommended that household products adhere to a previously published standard of a maximum limit of 5 ppm, with an ultimate target of 1 ppm contamination by chromium.
authors.affiliation: SEAC Toxicology Unit, Unilever Research, Sharnbrook, Bedford, UK.
authors.forename: D
authors.initials: D
authors.lastname: Basketter
authors.forename: L
authors.initials: L
authors.lastname: Horev
authors.forename: D
authors.initials: D
authors.lastname: Slodovnik
authors.forename: S
authors.initials: S
authors.lastname: Merimes
authors.forename: A
authors.initials: A
authors.lastname: Trattner
authors.forename: A
authors.initials: A
authors.lastname: Ingber
mesh_terms: D000328:Adult; D000485:Allergens / Q000008:administration & dosage / Q000009:adverse effects*; D002857:Chromium / Q000008:administration & dosage / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012867:Skin / Q000187:drug effects; D020711:Threshold Limit Values
chemical_list: D000485:Allergens; D002857:Chromium