title: Improved bone regeneration and root coverage using a resorbable membrane with physically assisted cell migration and DFDBA.
abstract: Twelve patients with 2 Miller Class I or II buccal recession defects measuring > or = 3.0 mm were treated using the principles of guided tissue regeneration and followed for 12 months. The effectiveness of a polylactide (Guidor) resorbable membrane (GA sites) was compared to a combination treatment of polylactide membrane plus polyglactin root-lining mesh (Vicryl) and demineralized freeze-dried bone allograft (DFDBA) (GVB sites) designed to enhance cell migration and bone regeneration. There was 90% mean soft tissue root coverage for the GVB sites and 78% for the GA sites. The mean osseous dehiscence area coverage with hard tissue was 75% for GVB sites and 30% for GA sites.
authors.affiliation: School of Dentistry, University of Louisville, 501 South Preston, Room 236, Louisville, Kentucky 40292, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Dodge
authors.forename: H
authors.initials: H
authors.lastname: Greenwell
authors.forename: C
authors.initials: C
authors.lastname: Drisko
authors.forename: J W
authors.initials: JW
authors.lastname: Wittwer
authors.forename: J
authors.initials: J
authors.lastname: Yancey
authors.forename: G
authors.initials: G
authors.lastname: Rebitski
mesh_terms: D020341:Absorbable Implants; D000328:Adult; D016301:Alveolar Bone Loss / Q000601:surgery; D001861:Bone Regeneration; D016025:Bone Transplantation / Q000379:methods; D002465:Cell Movement; D003648:Decalcification Technique; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005612:Freeze Drying; D005889:Gingival Recession / Q000601:surgery*; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D015588:Observer Variation; D010512:Periodontal Index; D011091:Polyesters; D011098:Polyglactin 910; D015203:Reproducibility of Results; D016037:Single-Blind Method; D013223:Statistics as Topic; D014021:Tissue Preservation; D014092:Tooth Root / Q000601:surgery*; D014184:Transplantation, Homologous
chemical_list: D008567:Membranes, Artificial; D011091:Polyesters; D011098:Polyglactin 910; C033616:poly(lactide)