title: Synthesis of non-nucleoside triphosphate analogues, a new type of substrates for terminal deoxynucleotidyl transferase.
abstract: A series of non-nucleoside triphosphate analogues were synthesized. In place of the nucleoside fragment, substituents bearing aromatic groups were introduced; the triphosphate component was replaced at alpha, beta, or gamma-positions by phosphonates. Alpha-[2-N-(9-Fluorenylmethoxycarbonyl)aminoethylphosphonyl]-beta,gamma-difluoromethylenediphosphonate (IIc) revealed the best substrate properties toward terminal deoxynucleotidyl transferase.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia Federation.
authors.forename: A A
authors.initials: AA
authors.lastname: Arzumanov
authors.forename: L S
authors.initials: LS
authors.lastname: Victorova
authors.forename: M V
authors.initials: MV
authors.lastname: Jasko
mesh_terms: D004253:DNA Nucleotidylexotransferase / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000378:metabolism; D013056:Spectrophotometry, Ultraviolet; D013379:Substrate Specificity
chemical_list: D009943:Organophosphorus Compounds; D004253:DNA Nucleotidylexotransferase