Lowering of circulating insulin and leptin is closely associated following weight reduction after vertical banded gastroplasty in obese women.
OBJECTIVE
To explore whether the lowering of insulin relates to changes in leptin following weight reduction after vertical banded gastroplasty (VBG) in seven grossly obese women (BMI 45.9 +/- 1.5 kg/m2).


RESULTS
At 6-24 months after VBG, BMI was reduced to 31.3 +/- 0.9 kg/m2 (p < 0.018), leptin from 43 +/- 9 to 12 +/- 2 ng/ml (p < 0.018) and insulin from 172 +/- 19 to 71 +/- 2 pmol/l (p=0.018). The reduction in leptin correlated to the reduction in insulin (r = 0.94, p = 0.002) but not to that of BMI (r = 0.05, NS).


CONCLUSIONS
Reduction in insulin seems more important for reduction in leptin than lowering of BMI, suggesting a close association between leptin and insulin in obese subjects.
Guldstrand
M
M
Department of Medicine, Danderyd Hospital, Malmö, Sweden.
Backman
L
L
Adamson
U
U
Lins
P E
PE
Ahrén
B
B
D000328:Adult; D015992:Body Mass Index; D005260:Female; D015391:Gastroplasty / Q000379:methods; D006801:Humans; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D011184:Postoperative Period; D015431:Weight Loss
D007328:Insulin; D020738:Leptin