Physico-chemical characterization of polysaccharide vaccines.
An increasing number of sophisticated analytical techniques, including NMR spectroscopy, are currently being applied to the quality control of polysaccharide and polysaccharide-based vaccines. These methodologies are providing more precise and more detailed profiles of these vaccines. NMR spectroscopy also provides a convenient and powerful technique to monitor alterations of the polysaccharide in the production of protein conjugate vaccines.
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Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20852, USA.
D001419:Bacteria / Q000737:chemistry; D001428:Bacterial Vaccines / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D011135:Polysaccharides, Bacterial / Q000737:chemistry*
D001428:Bacterial Vaccines; D011135:Polysaccharides, Bacterial