Exercise improved accumulation of visceral fat and simultaneously impaired endothelium-dependent relaxation in old rats.
Exercise decreases plasma total cholesterol and triglycerides, and simultaneously, increases high density lipoprotein (HDL) cholesterol. Furthermore, it has been reported that exercise improves insulin resistance. As a result, exercise is believed to aid in preventing atherosclerosis. However, we do not know whether exercise protects against the development of atherosclerosis in the elderly. The aim of this study was to ascertain whether exercise prevented atherosclerosis in aorta of old rats. Exercise for three months did not affect plasma lipid levels but decreased accumulation of visceral fat and body weight without the reduction of food intake in two year old rats. Exercise also decreased triglycerides in liver and gastrocnemius white muscle. Exercise resulted in an elevation of plasma lipid peroxide (LPO) levels without affecting superoxide dismutase (SOD). Exercise impaired the endothelium-dependent relaxation of the thoracic aorta caused by acetylcholine in old rats. In summary, the results of our study indicate that exercise induces the reduction of visceral fat, body weight and triglyceride contents in tissues in old rats. These results seems to show that exercise improves insulin resistance. However, exercise simultaneously may cause impaired endothelium-dependent relaxation by elevation of LPO in old rats.
Tsutsumi
K
K
Nutrition Research Institute, Otsuka Pharmaceutical Factory, Inc., Tokushima, Japan. tutumikz@otsukakj.co.jp
Kusunoki
M
M
Hara
T
T
Okada
K
K
Sakamoto
S
S
Ohnaka
M
M
Nakay
Y
Y
D000273:Adipose Tissue; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D001806:Blood Urea Nitrogen; D001835:Body Weight; D003404:Creatinine / Q000097:blood; D004730:Endothelium, Vascular / Q000502:physiology*; D005247:Feeding Behavior; D007328:Insulin / Q000097:blood; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D009126:Muscle Relaxation; D010805:Physical Conditioning, Animal; D051381:Rats; D013482:Superoxide Dismutase / Q000097:blood; D014781:Viscera
D001786:Blood Glucose; D007328:Insulin; D008055:Lipids; D003404:Creatinine; D013482:Superoxide Dismutase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase