title: [Safety and value of minilaparoscopy in high risk patients].
abstract: BACKGROUND
  Coagulopathies and thrombocytopenia may constitute contraindications for percutaneous liver biopsy. We investigated the safety and value of visually guided liver biopsy using minilaparoscopy in patients with coagulation disorders.
  
  
  METHODS
  We studied 50 patients requiring a liver biopsy, but whose risk of severe bleeding complications was considered too high for the following reasons: INR > 1.5 (40%), platelets 50/nl (36%) or both (18%), other coagulopathies (6%). Indications for liver biopsy were: Hepatopathy of unknown etiology (38%), fulminant liver failure (18%), virus induced hepatitis (6%) and evaluation for liver transplantation (38%). Patients underwent minimally invasive diagnostic laparoscopy and liver biopsies were obtained with a Silverman or Menghini needle. Bleeding was stopped or prevented by coagulation with the argon beamer or a monopolar probe or application of fibrin glue.
  
  
  RESULTS
  Macroscopical assessment of the liver was possible in all patients. A liver biopsy was performed in 47/50. 46/47 biopsy specimens were large enough to allow reliable histological evaluation. The diagnostic procedure had major therapeutic consequences in 35/40 patients. No relevant bleeding from the liver biopsy site occurred.
  
  
  CONCLUSIONS
  We demonstrated that laparoscopically guided liver biopsy is safe even in patients with a very high risk of bleeding complications because of coagulation disorders. It is therefore an attractive and preferable alternative to transjugular liver biopsy.
authors.affiliation: I. Medizinische Klinik der Johannes Gutenberg Universtät Mainz.
authors.forename: U
authors.initials: U
authors.lastname: Denzer
authors.forename: I
authors.initials: I
authors.lastname: Helmreich-Becker
authors.forename: P R
authors.initials: PR
authors.lastname: Galle
authors.forename: A W
authors.initials: AW
authors.lastname: Lohse
mesh_terms: D000328:Adult; D000368:Aged; D001707:Biopsy, Needle / Q000295:instrumentation*; D001780:Blood Coagulation Tests; D005260:Female; D006474:Hemorrhagic Disorders / Q000473:pathology*; D006801:Humans; D020706:Laparoscopes; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
vernacular_title: Sicherheit und Wertigkeit der Minilaparoskopie bei Hochrisikopatienten.