title: Common variable immunodeficiency.
abstract: Common variable immunodeficiency (CVI) is a heterogeneous immunodeficiency syndrome characterized by hypogammaglobulinemia, recurrent bacterial infections, and a variety of immunological abnormalities. In addition to recurrent infections, patients with this syndrome also suffer from an increased incidence of autoimmune disease and malignancy. Because the spectrum of associated diseases is broad, patients with CVI are seen by a variety of medical specialists. In this review, the pathogenesis, clinical manifestations, diagnosis, and treatment of CVI are discussed.
authors.affiliation: Laboratory of Immunoregulation, National Institute of Allergy and Infectious Disease, National Institutes of Health, Bethesda, Maryland 20892, USA. msneller@niaid.nih.gov
authors.forename: M C
authors.initials: MC
authors.lastname: Sneller
mesh_terms: D015551:Autoimmunity; D001424:Bacterial Infections / Q000209:etiology; D017074:Common Variable Immunodeficiency / Q000175:diagnosis / Q000453:epidemiology / Q000503:physiopathology* / Q000628:therapy; D005060:Europe / Q000208:ethnology; D006105:Granulomatous Disease, Chronic / Q000209:etiology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D015994:Incidence; D008232:Lymphoproliferative Disorders / Q000209:etiology; D012008:Recurrence; D014481:United States / Q000453:epidemiology; D044465:White People
chemical_list: D016756:Immunoglobulins, Intravenous