Antigen traffic pathways in dendritic cells.
Dendritic cells (DC) are now believed to be the principal initiators of T cell-mediated immune responses. Their location in body tissues, migratory behaviour in response to inflammatory stimuli, endocytic properties, expression of MHC molecules and key T cell stimulatory molecules and many other attributes place these remarkable cells in a unique and influential position in the immune system. Progress in DC culture methods has recently allowed in-depth studies on the cell biological features that enable them to fulfill their crucial role in the immune response.
Watts
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C
Department of Biochemistry, University of Dundee, Dundee, DD1 5EH, UK. c.watts@dundee.ac.uk
Amigorena
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S
D000818:Animals; D017951:Antigen Presentation; D000941:Antigens / Q000378:metabolism; D001692:Biological Transport; D002448:Cell Adhesion; D018929:Cell Culture Techniques; D002465:Cell Movement; D003713:Dendritic Cells / Q000166:cytology* / Q000378:metabolism*; D004705:Endocytosis; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
D000941:Antigens; D015395:Histocompatibility Antigens Class I