Effect of propranolol and midazolam therapy on hemodynamic parameters in rabbits.
Some of anesthetic drugs cause cardiac arrhythmia, myocardial depression, blood pressure as well as hepatic and renal blood flow decrease. The aim of the following research study was the evaluation of midazolam effect on hemodynamic parameters in propranolol-treated rabbits. The following parameters: cardiac output and stroke volume, peripheral blood resistance, heart rate and blood pressure were estimated in the hemodynamics study. Blood pressure was significantly higher in case of propranolol and midazolam therapy as compared with midazolam alone. Blood pressure inconstancy did not exceed 20% of the initial value. Midazolam did not improve the depressive effect of propranolol on heart rate. The peripheral vascular resistance in coherent propranolol and midazolam therapy oscillated at the values observed after sole midazolam administration. After midazolam administration with propranolol, insignificant increase of cardiac output and stroke volume during the first minutes of experimental protocol correlated with marked decrease of peripheral blood resistance at the same time.
Wiktorowska-Owczarek
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A
Department of Pharmacology, Chair of Pharmacology, Medical University, Łódź, Poland.
Owczarek
J
J
Obolewska
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A
Orszulak-Michalak
D
D
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D018686:Anesthetics, Intravenous; D011433:Propranolol; D008874:Midazolam