Tolerance of efavirenz in children.
OBJECTIVE
To extend the limited knowledge of efavirenz tolerance in children.


METHODS
An observational study of 33 children given efavirenz combined with various others agents and followed in a single institution.


RESULTS
Fifteen (42%) of the children presented at least one clinically discernable side effect, cutaneous (n = 5), nervous system (n = 10), or both (n = 2). Intolerance led to treatment interruption in seven children but the main symptom was transitory dizziness or other signs similar to those observed in adults.


CONCLUSIONS
Early, often transient nervous system side effects require careful preparation with the child and his family to avoid premature and inadequate withdrawal from treatment.
Teglas
J P
JP
INSERM U292, H pital Bicêtre, Le Kremlin, France.
Quartier
P
P
Treluyer
J M
JM
Burgard
M
M
Gregoire
V
V
Blanche
S
S
D000293:Adolescent; D000480:Alkynes; D019380:Anti-HIV Agents / Q000009:adverse effects* / Q000627:therapeutic use; D048588:Benzoxazines; D018791:CD4 Lymphocyte Count; D002648:Child; D003521:Cyclopropanes; D015658:HIV Infections / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D006801:Humans; D010078:Oxazines / Q000009:adverse effects* / Q000627:therapeutic use; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D019562:Viral Load
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D018894:Reverse Transcriptase Inhibitors; C098320:efavirenz