title: [Effects of intravenous nicardipine, prostaglandin E1, nitroglycerin, sodium nitroprusside, and epidural lidocaine on hepatic and renal blood flow during hypotensive anesthesia].
abstract: We studied the effects of intravenous nicardipine (NIC), prostaglandin E1 (PGE1), nitroglycerin (TNG), sodium nitroprusside (SNP) and epidural lidocaine (LID) on hepatic and renal blood flow during general anesthesia (nitrous oxide-oxygen-sevoflurane) in 46 female patients undergoing unilateral total hip arthroplasty. During operations, hepatic blood flow, glomerular filtration rate, renal plasma flow, and renal tubular injury were measured by R 15 ICG (15 minutes retention rate of indocyanine green), CCR (creatinine clearance), CPAH (para-aminohippuric acid clearance), and urinary excretion of NAG and beta 2-microglobulin. Significant elevation of R 15 ICG was observed in the hypotensive state in the TNG group and the elevation of R 15 ICG indicates that blood flow to the liver has decreased during hypotensive anesthesia. Urine volume in the PGE1 group was larger than that in the TNG, SNP or LID group. CCR in the PGE1 group was larger than that in the NIC, TNG or SNP groups. CPAH in the PGE1 group was larger than that in the SNP or LID group. The value of urine NAG in the TNG group was larger than that in the NIC or PGE1 group. The value of urine beta 2-microglobulin in the NIC group was larger than that in the PGE1 or SNP group. The results of urine volume, CCR, CPAH, urine NAG, and urine beta 2-microglobulin indicate that blood flow to the kidneys was greater in the PGE1 group as compared to other groups. This study indicates that prostaglandin E1 is the best hypotensive drug for hepatic and renal blood flow during hypotensive anesthesia.
authors.affiliation: Department of Anesthesiology and Resuscitology, Ehime University School of Medicine, Ehime 791-0295.
authors.forename: E
authors.initials: E
authors.lastname: Tabo
authors.forename: T
authors.initials: T
authors.lastname: Yorozuya
authors.forename: I
authors.initials: I
authors.lastname: Shimizu
authors.forename: N
authors.initials: N
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Nagaro
authors.forename: T
authors.initials: T
authors.lastname: Arai
mesh_terms: D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage / Q000009:adverse effects*; D000768:Anesthesia, General / Q000379:methods*; D019644:Arthroplasty, Replacement, Hip; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007023:Hypotension, Controlled / Q000379:methods*; D007262:Infusions, Intravenous; D007268:Injections, Epidural; D007432:Intraoperative Period; D007684:Kidney Tubules / Q000187:drug effects; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects*; D008102:Liver Circulation / Q000187:drug effects*; D008875:Middle Aged; D009529:Nicardipine / Q000008:administration & dosage / Q000009:adverse effects*; D005996:Nitroglycerin / Q000008:administration & dosage / Q000009:adverse effects*; D009599:Nitroprusside / Q000008:administration & dosage / Q000009:adverse effects*; D012079:Renal Circulation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014665:Vasodilator Agents; D009599:Nitroprusside; D008012:Lidocaine; D009529:Nicardipine; D000527:Alprostadil; D005996:Nitroglycerin