Electrochemical oxidation at carbon paste electrode of tacrine and 1-hydroxytacrine and differential pulse voltammetric determination of tacrine in pharmaceuticals and human urine.
The electrochemical oxidation of tacrine and its 1-OH-metabolite, has been studied by cyclic voltammetry and differential pulse voltammetry by using carbon paste electrodes. The peak current-concentration relationship was found to be linear up to 20 micrograms ml-1 with detection limits of 0.06 microgram ml-1 for tacrine and 0.18 microgram ml-1 for 1-OH-tacrine and quantitation limits of 0.20 microgram ml-1 for tacrine and 0.37 microgram ml-1 for 1-OH-tacrine. A method for determining tacrine by differential pulse voltammetry in pharmaceuticals and human urine, in the presence of 1-OH-tacrine, has been developed.
Aparicio
I
I
Callejón
M
M
Jiménez
J C
JC
Bello
M A
MA
Guiraúm
A
A
D002244:Carbon; D004563:Electrochemistry; D004566:Electrodes; D006801:Humans; D013619:Tacrine / Q000031:analogs & derivatives* / Q000032:analysis* / Q000737:chemistry / Q000652:urine
D013619:Tacrine; D002244:Carbon; C056424:velnacrine