[Transforming growth factor-beta signaling and cancer].
Transforming growth factor-beta (TGF-beta) is a multifunctional cytokine that inhibits the growth of most types of cells and induces fibrosis of various tissues. TGF-beta binds to two different types of serine/threonine kinase receptors, and activate Smad proteins. Perturbation of the TGF-beta signaling pathway results in tumorigenesis of various tissues. TGF-beta/Smad signaling is regulated by several regulatory proteins, including inhibitory Smads and transcriptional corepressors. Abnormalities in these negative regulators of TGF-beta signaling may also involved in tumorigenesis of certain tissues.
Miyazono
K
K
Department of Molecular Pathology, Graduate School of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033 Japan.
D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000473:pathology; D009687:Nuclear Proteins / Q000378:metabolism / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000378:metabolism / Q000502:physiology; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D015534:Trans-Activators / Q000378:metabolism / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic; D016212:Transforming Growth Factor beta / Q000378:metabolism / Q000502:physiology*
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D018125:Receptors, Transforming Growth Factor beta; D015534:Trans-Activators; D014157:Transcription Factors; D016212:Transforming Growth Factor beta; C060614:SKI protein, human