Detection of cytomegalovirus in urine of hearing-impaired and mentally retarded children by PCR and cell culture.
This study was carried out to determine the prevalence of cytomegalovirus (CMV) excretion in urine among 30 deaf children and 91 mentally retarded children by cell culture and PCR. As a control, urine samples from 121 children without hearing disability or mental retardation were also tested. The study revealed that 15 of 30 (50%) deaf children and 16 of 91 (17.6%) mentally retarded children were excreting CMV in their urine. Among the control group we observed that only 2 of the 121 (1.8%) children were CMV excretors. As CMV excretion in urine is generally considered to indicate a congenital infection, it is very likely that congenital CMV is highly incriminated in mental retardation and deafness among children in Mauritius.
Pultoo
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A
Faculty of Science, University of Mauritius, Reduit, Mauritius.
Jankee
H
H
Meetoo
G
G
Pyndiah
M N
MN
Khittoo
G
G
D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000235:genetics / Q000302:isolation & purification*; D003586:Cytomegalovirus Infections / Q000151:congenital* / Q000453:epidemiology*; D006801:Humans; D019986:Persons with Hearing Disabilities; D019989:Persons with Intellectual Disabilities; D016133:Polymerase Chain Reaction / Q000379:methods; D014556:Urine / Q000821:virology*; D014776:Virus Cultivation / Q000379:methods