title: Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly.
abstract: The aims of this study were to evaluate the effects of dietary glucose supplementation on gastric emptying (GE) of both glucose and fat, postprandial blood glucose homeostasis, and appetite in eight older subjects (4 males, 4 females, aged 65--84 yr). GE of a drink (15 ml olive oil and 33 g glucose dissolved in 185 ml water), blood glucose, insulin, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and appetite (diet diaries, visual analog scales, and food intake at a buffet meal consumed after the GE study) were evaluated twice, after 10 days on a standard or a glucose-supplemented diet (70 g glucose 3 times a day). Glucose supplementation accelerated GE of glucose (P < 0.05), but not oil; there was a trend for an increase in GIP (at 15 min, P = 0.06), no change in GLP-1, an earlier insulin peak (P < 0.01), and a subsequent reduction in blood glucose (at 75 min, P < 0.01). Glucose supplementation had no effect on food intake during each diet so that energy intake was greater (P < 0.001) during the glucose-supplemented diet. Appetite ratings and energy intake at the buffet meal were not different. We conclude that, in older subjects, glucose supplementation 1) accelerates GE of glucose, but not fat; 2) modifies postprandial blood glucose homeostasis; and 3) increases energy intake.
authors.affiliation: Department of Medicine, University of Adelaide, Royal Adelaide Hospital, North Terrace, Adelaide 5000, South Australia, Australia.
authors.forename: K
authors.initials: K
authors.lastname: Beckoff
authors.forename: C G
authors.initials: CG
authors.lastname: MacIntosh
authors.forename: I M
authors.initials: IM
authors.lastname: Chapman
authors.forename: J M
authors.initials: JM
authors.lastname: Wishart
authors.forename: H A
authors.initials: HA
authors.lastname: Morris
authors.forename: M
authors.initials: M
authors.lastname: Horowitz
authors.forename: K L
authors.initials: KL
authors.lastname: Jones
mesh_terms: D000368:Aged / Q000502:physiology*; D000369:Aged, 80 and over; D001066:Appetite / Q000187:drug effects / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism*; D004040:Dietary Carbohydrates; D004042:Dietary Fats, Unsaturated / Q000494:pharmacology; D002149:Energy Intake / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects / Q000502:physiology*; D005749:Gastric Inhibitory Polypeptide / Q000097:blood; D005934:Glucagon / Q000097:blood; D052216:Glucagon-Like Peptide 1; D005947:Glucose / Q000494:pharmacology*; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008297:Male; D000069463:Olive Oil; D010446:Peptide Fragments / Q000097:blood; D010938:Plant Oils / Q000494:pharmacology; D011498:Protein Precursors / Q000097:blood; D012044:Regression Analysis; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004042:Dietary Fats, Unsaturated; D007328:Insulin; D000069463:Olive Oil; D010446:Peptide Fragments; D010938:Plant Oils; D011498:Protein Precursors; D005749:Gastric Inhibitory Polypeptide; D052216:Glucagon-Like Peptide 1; D005934:Glucagon; D005947:Glucose