title: Contextual insensitivity in schizophrenic language processing: evidence from lexical ambiguity.
abstract: The authors investigated whether contextual failures in schizophrenia are due to deficits in the detection of context or the inhibition of contextually irrelevant information. Eighteen schizophrenia patients and 24 nonpsychiatric controls were tested via a cross-modal semantic priming task. Participants heard sentences containing homonyms and made lexical decisions about visual targets related to the homonyms' dominant or subordinate meanings. When sentences moderately biased subordinate meanings (e.g., the animal enclosure meaning of pen), schizophrenia patients showed priming of dominant targets (e.g., paper) and subordinate targets (e.g., pig). In contrast, controls showed priming only of subordinate targets. When contexts strongly biased subordinate meanings, both groups showed priming only of subordinate targets. The results suggest that inhibitory deficits rather than context detection deficits underlie contextual failures in schizophrenia.
authors.affiliation: Psychology Research Laboratory, Mailman Research Center, McLean Hospital, Belmont, Massachusetts 02478, USA. dtitone@mclean.harvard.edu
authors.forename: D
authors.initials: D
authors.lastname: Titone
authors.forename: D L
authors.initials: DL
authors.lastname: Levy
authors.forename: P S
authors.initials: PS
authors.lastname: Holzman
mesh_terms: D000328:Adult; D001288:Attention; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D008875:Middle Aged; D010153:Paired-Associate Learning; D011578:Psycholinguistics; D012559:Schizophrenia / Q000175:diagnosis*; D012564:Schizophrenic Language; D012660:Semantics; D013067:Speech Perception