title: Disruption of differentiated functions during viral infection in vivo. V. Mapping of a locus involved in susceptibility of mice to growth hormone deficiency due to persistent lymphocytic choriomeningitis virus infection.
abstract: Lymphocytic choriomeningitis virus (LCMV) Armstrong strain selectively and persistently infects the majority of growth hormone (GH) producing cells in the anterior lobe of pituitary glands of C3H/St mice but negligibly infects GH producing cells of BALB/WEHI mice (Oldstone et al., Virology 142, 175--182, 1985; Oldstone et al., Science 218, 1125--1127, 1982). Although infected GH cells remain free of structural damage, disrupted initiation of GH transcription (Klavinskis and Oldstone, J. Gen. Virol. 68, 1867--1873, 1989; Valsamakis et al., Virology 156, 214--220, 1987) occurs with a resultant decrease in the synthesis of GH, leading to a failure of growth and development (Oldstone et al., Science 218, 1125--1127, 1982). Microsatellite mapping of DNA obtained from 101 individual C3H/St x BALB/WEHI F1 x F1 mice shows that the growth failure correlates with host genes linked (P value 0.0008) on chromosome 17 just outside of the H-2D MHC site between D17 Mit24 and D17 Mit51, a distance of 2.5 cM. The genetic mapping done here excludes alpha-dystroglycan (alpha-DG), a known receptor for LCMV (Cao et al., Science 282, 2079--2081, 1998) in pathogenesis of GH disease, as alpha-DG is encoded in the mouse by a gene residing on chromosome 9 (Yotsumoto et al., Hum. Mol. Genet. 5, 1259--1267, 1996).
authors.affiliation: Unite des Virus Lents, URA 1930 CNRS, Institut Pasteur, 75724 Paris Cedex 15, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Bureau
authors.forename: S
authors.initials: S
authors.lastname: Le Goff
authors.forename: D
authors.initials: D
authors.lastname: Thomas
authors.forename: A F
authors.initials: AF
authors.lastname: Parlow
authors.forename: J C
authors.initials: JC
authors.lastname: de la Torre
authors.forename: D
authors.initials: D
authors.lastname: Homann
authors.forename: M
authors.initials: M
authors.lastname: Brahic
authors.forename: M B
authors.initials: MB
authors.lastname: Oldstone
mesh_terms: D000818:Animals; D001835:Body Weight; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003598:Cytoskeletal Proteins / Q000235:genetics; D004393:Dwarfism, Pituitary / Q000150:complications* / Q000235:genetics* / Q000378:metabolism / Q000821:virology; D049030:Dystroglycans; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D013006:Growth Hormone / Q000032:analysis / Q000172:deficiency*; D008126:Lod Score; D008216:Lymphocytic Choriomeningitis / Q000150:complications* / Q000503:physiopathology / Q000821:virology; D008217:Lymphocytic choriomeningitis virus / Q000502:physiology*; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D018895:Microsatellite Repeats / Q000235:genetics; D010902:Pituitary Gland / Q000737:chemistry; D013223:Statistics as Topic; D013577:Syndrome
chemical_list: D003598:Cytoskeletal Proteins; D008562:Membrane Glycoproteins; D049030:Dystroglycans; D013006:Growth Hormone