title: Severe upper airway obstruction in the tropics requiring intensive care.
abstract: BACKGROUND
  The clinical profile of severe upper airway obstruction, a challenging acute pediatric emergency, has not been extensively documented in the developing nations of the tropics.
  
  
  METHODS
  The diagnostic categories, severity of illness and outcome from 63 episodes of severe upper airway obstruction in 56 children admitted to the Pediatric Intensive Care Unit between January 1994 and December 1999 were reviewed. Outcome variables studied included requirement for ventilation, mortality and complications. Severity of illness was determined with the Pediatric Risk of Mortality (PRISM) II score.
  
  
  RESULTS
  Viral croup (29%) was the most common diagnosis, followed by mediastinal malignancy (13%), bacterial tracheitis (11%) and Pierre Robin syndrome (11%). There were no admissions for acute epiglottitis. Thirty episodes (48%) required ventilation for a median duration of 4.0 days. Bacterial tracheitis (100%) and subglottic stenosis (100%) were the most likely diagnoses requiring ventilation. Difficulty in intubation was encountered in 13 episodes (43%) involving, in particular, patients with bacterial tracheitis (83%; P = 0.006). Only two patients required a tracheostomy. The overall mortality was 11%. The PRISM score for all categories was generally low (mean 10.3 +/- 1.0; median 9.0). Non-survivors had a significantly higher PRISM II score than survivors (27.4 +/- 9.7 vs 8.1 +/- 4.9, respectively; P = 0.002) and were more likely to include children with bacterial tracheitis and mediastinal malignancy.
  
  
  CONCLUSIONS
  There is marked heterogeneity in the causes of upper airway obstruction in the tropics with viral croup remaining the most common. A significant proportion required ventilation, but outcome is generally favorable, except in those with bacterial tracheitis and mediastinal malignancy.
authors.affiliation: Department of Pediatrics, University Malaya Medical Center, Kuala Lumpur, Malaysia. patrick@medicine.med.um.edu.my
authors.forename: P W
authors.initials: PW
authors.lastname: Chan
authors.forename: A
authors.initials: A
authors.lastname: Goh
authors.forename: L
authors.initials: L
authors.lastname: Lum
mesh_terms: D000402:Airway Obstruction / Q000145:classification / Q000209:etiology / Q000401:mortality / Q000628:therapy; D016638:Critical Illness; D005260:Female; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D008296:Malaysia / Q000453:epidemiology; D008297:Male; D012121:Respiration, Artificial; D012720:Severity of Illness Index; D015996:Survival Rate; D016896:Treatment Outcome; D014329:Tropical Climate