title: [One-pot synthesis of dl-naproxen by rearrangement].
abstract: OBJECTIVE
  To synthesize dl-naproxen by rearrangement method.
  
  
  METHODS
  dl-Naproxen was synthesized by halogenation, ketalization, rearrangement and hydrolysis, using cupric halide as halogenation agent.
  
  
  RESULTS
  Total yields were 74.0%-92.6% based on 6-methoxy-2-propionyl naphthalene.
  
  
  CONCLUSIONS
  Total yield was higher by one-pot rearrangement approach.
authors.affiliation: College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. huaixi@mail.hunu.edu.cn
authors.forename: A X
authors.initials: AX
authors.lastname: Hu
authors.forename: X M
authors.initials: XM
authors.lastname: Dong
authors.forename: S C
authors.initials: SC
authors.lastname: Cao
authors.forename: Y P
authors.initials: YP
authors.lastname: Cheng
authors.forename: L
authors.initials: L
authors.lastname: Chen
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D006868:Hydrolysis; D009288:Naproxen / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000378:metabolism*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D009942:Organometallic Compounds; C015092:cupric acetate; D009288:Naproxen