title: [A case of fixed drug eruption due to ephedrine hydrochloride].
abstract: We report the case of a 29-year old female who developed a fixed drug eruption due to ephedrine hydrochloride administered intravenously during the cesarean section. On the day of the operation a palm-sized dark brown macula with half egg-sized erosion appeared on her right lower thigh. We diagnosed her disease as fixed drug eruption and examined the causative agent among all the 14 drugs used from admission to the appearance of fixed drug eruption. Each of systemic challenge, patch test on the lesion, intradermal and subcutaneous injection on the lesion with ephedrine hydrochloride showed positive reaction. As far as we have been able to search, our case is the first one of fixed drug eruption due to ephedrine hydrochloride.
authors.affiliation: Department of Anesthesiology, Kishiwada City Hospital, Kishiwada 592-8501.
authors.forename: K
authors.initials: K
authors.lastname: Tanimoto
authors.forename: T
authors.initials: T
authors.lastname: Shimakage
authors.forename: Y
authors.initials: Y
authors.lastname: Ayabe
authors.forename: T
authors.initials: T
authors.lastname: Yamakawa
authors.forename: M
authors.initials: M
authors.lastname: Kumekawa
authors.forename: S
authors.initials: S
authors.lastname: Moriyama
mesh_terms: D000328:Adult; D000773:Anesthesia, Obstetrical; D002585:Cesarean Section; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D004809:Ephedrine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D012882:Skin Tests; D014662:Vasoconstrictor Agents / Q000009:adverse effects*
chemical_list: D014662:Vasoconstrictor Agents; D004809:Ephedrine