BEHAB/brevican: an extracellular matrix component associated with invasive glioma.
The extracellular matrix (ECM) has a prominent role in many physiological processes, including organ development, wound healing, and neoplastic growth and invasion. In each of these processes, changes in the composition of the matrix can lead to increased cell movement. In this review, we discuss the role of ECM components in glioma invasion, with special emphasis on the brain-specific proteoglycan, Brain-Enriched Hyaluronan Binding (BEHAB)/brevican.
Gary
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SC
Section of Neurobiology, Yale University, New Haven, Connecticut, USA.
Hockfield
S
S
D001932:Brain Neoplasms / Q000378:metabolism* / Q000473:pathology; D058581:Brevican; D002352:Carrier Proteins / Q000378:metabolism*; D011508:Chondroitin Sulfate Proteoglycans / Q000378:metabolism*; D016326:Extracellular Matrix Proteins / Q000378:metabolism; D005910:Glioma / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D037181:Lectins, C-Type; D009361:Neoplasm Invasiveness / Q000473:pathology; D009419:Nerve Tissue Proteins / Q000378:metabolism*
C546938:BCAN protein, human; D058581:Brevican; D002352:Carrier Proteins; D011508:Chondroitin Sulfate Proteoglycans; D016326:Extracellular Matrix Proteins; D037181:Lectins, C-Type; D009419:Nerve Tissue Proteins