Low-dose aspirin does not increase implantation rates in patients undergoing intracytoplasmic sperm injection: a prospective randomized study.
OBJECTIVE
The aim was to evaluate the effect of aspirin on pregnancy and implantation rates in an unselected group of patients undergoing intracytoplasmic sperm injection (ICSI).


METHODS
Two hundred and seventy-nine patients were randomized to receive 80 mg of aspirin (n = 139) or no treatment (r = 136) starting from the first day of controlled ovarian hyperstimulation.


RESULTS
Duration of stimulation, gonadotropin consumption, peak estradiol, number of oocytes retrieved, fertilization rate, cleavage rate, and number of embryos transferred were similar in the two groups. Implantation and clinical pregnancy rates were 15.6% and 39.6% versus 15.1% and 43.4% in aspirin treated and untreated groups, respectively (P > 0.05).


CONCLUSIONS
Low-dose aspirin administration does not improve implantation and pregnancy rates in an unselected group of patients undergoing ICSI.
Urman
B
B
Assisted Reproduction Unit, VKV American Hospital of Istanbul, Guzelbahce Sok No. 2, Nisantasi 80200, Istanbul, Turkey.
Mercan
R
R
Alatas
C
C
Balaban
B
B
Isiklar
A
A
Nuhoglu
A
A
D000328:Adult; D000367:Age Factors; D001241:Aspirin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D006801:Humans; D007248:Infertility, Male; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D020554:Sperm Injections, Intracytoplasmic
D001241:Aspirin