Phaeochromocytomas discovered during coronial autopsies in Sydney, Melbourne and Auckland.
BACKGROUND
The diagnosis of phaeochromocytoma can be difficult and previous autopsy studies have found that many of these tumours are not recognised during life.


OBJECTIVE
To determine the incidence of phaeochromocytoma during coronial autopsies and the characteristics of the individuals concerned.


METHODS
Review of coronial autopsy records from Auckland (1981-97), Melbourne (1991-97) and Sydney (1991-97).


RESULTS
Twenty-two patients were found giving an incidence of 0.05% (one tumour per 2031 autopsies) with similar figures in each centre. Thirteen of the patients were men, 12 were overweight (body mass index >25 kg/m2) and three of the seven Auckland patients were Maori. Fourteen of the tumours were left-sided, one was extra-adrenal and none had metastasised. The one patient with bilateral tumours had multiple endocrine neoplasia syndrome type 2 (MEN-2) which had not been recognised during life. The heart weight was increased in 95% of the patients. The tumour may have contributed to the patient's death in up to 50% of the cases, although the true significance of these lesions as a cause of death remains unclear. Three patients died soon after general anaesthetics had been given for unrelated reasons.


CONCLUSIONS
Even though phaeochromocytomas are uncommon, we fail to diagnose a significant number of these tumours during life. Methods are needed to increase the detection of phaeochromocytoma and to distinguish functional and non-functional tumours.
McNeil
A R
AR
Department of Molecular Medicine, University of Auckland, New Zealand.
Blok
B H
BH
Koelmeyer
T D
TD
Burke
M P
MP
Hilton
J M
JM
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D015992:Body Mass Index; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000175:diagnosis*