title: Parathyroid hormone-related peptide producing cholangiocellular carcinoma with a marked psammoma formation.
abstract: Humoral hypercalcemia caused by parathyroid hormone-related peptide (PTHrP), associated with cholangiocellular carcinoma (CCC), has rarely been documented. There have been no reports of CCC associated with extensive calcification of the tumor with psammoma body formation. A 66-year-old man was admitted with a large calcified tumor in the liver detected on an abdominal X-ray. An ultrasound-guided fine needle biopsy specimen of the liver tumor showed evidence of adenocarcinoma. He had hypercalcemia with an elevated PTHrP level. The patient died because of disseminated intravascular coagulation and progressive hepatic failure. A postmortem examination revealed a large poorly differentiated CCC in the liver. Immunohistochemical examination showed the presence of PTHrP-positive tumor cells. The calcified lesion consisted of a number of accumulated psammoma bodies. We present a case of PTHrP producing CCC with a marked psammoma formation.
authors.affiliation: Department of Clinical Pathophysiology, School of Health Sciences, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi, Kitakyushu, Fukuoka 807-8555, Japan. shyamada@med.uoeh-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Sanefuji
authors.forename: H
authors.initials: H
authors.lastname: Morimoto
authors.forename: Y
authors.initials: Y
authors.lastname: Harada
authors.forename: S
authors.initials: S
authors.lastname: Mine
authors.forename: I
authors.initials: I
authors.lastname: Morimoto
authors.forename: S
authors.initials: S
authors.lastname: Eto
mesh_terms: D000368:Aged; D000792:Angiography; D001650:Bile Duct Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D001653:Bile Ducts, Intrahepatic; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology*; D018281:Cholangiocarcinoma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D008297:Male; D044162:Parathyroid Hormone-Related Protein; D014176:Protein Biosynthesis; D011860:Radiography, Abdominal; D014057:Tomography, X-Ray Computed
chemical_list: C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein