title: Does cell-saver blood administration and free hemoglobin load cause renal dysfunction?
abstract: Our aim was to evaluate the impact of cell-saver volume and free hemoglobin load on renal dysfunction. Intraoperative blood salvage was conducted in standard fashion, and in each case a sample of the blood was removed for testing. Outcome data on individual patients were collected during a 6-year period (1992-1998). The total amount of free hemoglobin each patient received was calculated. Renal dysfunction was defined as a rise in creatinine level of 1.0 mg/dL above baseline. There were a total of 125 patients who received salvaged blood. The free hemoglobin concentration ranged from 19 to 304 mg/dL (mean, 87.5 mg/dL). Patients were stratified into groups on the basis of the total free hemoglobin received, and the Kruskal-Wallis test demonstrated a difference between groups in the prevalence of renal dysfunction (P < 0.001). A total of 15 patients (12%) had significant postoperative renal dysfunction. There was an association between the amount of free hemoglobin load and subsequent renal dysfunction. This may warrant further study toward establishing policies and limits regarding maximal free hemoglobin blood.
authors.affiliation: Department of Surgery, University of Louisville School of Medicine, and the Veterans Administration Medical Center, Kentucky 40292, USA.
authors.forename: C T
authors.initials: CT
authors.lastname: Klodell
authors.forename: J D
authors.initials: JD
authors.lastname: Richardson
authors.forename: T M
authors.initials: TM
authors.lastname: Bergamini
authors.forename: D A
authors.initials: DA
authors.lastname: Spain
mesh_terms: D000328:Adult; D000368:Aged; D001804:Blood Transfusion, Autologous / Q000009:adverse effects / Q000379:methods*; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006454:Hemoglobins / Q000008:administration & dosage*; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000378:metabolism; D008297:Male; D008875:Middle Aged
chemical_list: D006454:Hemoglobins; D003404:Creatinine