[The ratios of apoC-III/apoC-II in normal full-term maternal bloods and their umbilical cord bloods].
In this paper, serum concentrations of CII and CIII in MB(n = 12) represented 158% and 237% of those in 20 specimens of normolipidemic venous blood from healthy fasting non-pregnant females(Control), and the CIII/CII ratio of MB(mean +/- SD = 3.6 +/- 0.4) was significantly higher than that of the Control(2.38 +/- 0.42). While the difference between the serum CII level in MB and that of 14 specimens of postmenopausal patients lipid-matched to MB(postM HL) was not significant, serum CIII concentration of MB was significantly higher than that of postM HL. Furthermore, while the difference between the CIII level in apoB-containing lipoproteins of MB and that of postM HL was not significant, the CIII concentration in HDL(HDL-CIII) of MB was significantly higher than that of postM HL. It was suggested that the effect of pregnancy on apoC levels which change in parallel with the TGs level might reflect the selective increase in HDL-CIII concentration. In addition, the positive correlation between HDL-CIII and apoA-I concentration in MB was significant. However, it has been reported that the CIII/CII ratio of patients with type III hyperlipidemia treated with estrogens had been successively increased, and it was also reported that estrogens stimulate the synthesis of CIII in hepatocytes. It was thus suggested that maternal CIII as well as apoA-I might be selectively overproduced in the liver by stimulation from increased endogenous estrogens during normal pregnancy. On the contrary, the serum concentrations of CII and CIII in UCB represented 71% and 55% of those in Control, and the CIII/CII ratio of UCB(1.87 +/- 0.5) was significantly lower than those of the Control. In UCB, the positive correlation between CIII and TGs was weak(p < 0.1) and CII did not correlate with markedly decreased TGs. Serum concentrations of CII, CIII and the ratio of CIII/CII in MB did not correlate with those in UCB, respectively. Moreover, birth weight and birth length of neonates positively correlated with concentrations of TGs, CII and CIII in MB, respectively, but not in UCB. In conclusion, the increased maternal CIII/CII ratio is due to the estrogen-induced raise of CIII while the reduced neonatal CIII/CII is related to the decrease in TGs. These observations suggest that fetal TGs-rich lipoprotein metabolism is not affected by maternal lipoprotein metabolism.
Ikeda
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Ikeda
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D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001056:Apolipoproteins C / Q000097:blood*; D004967:Estrogens / Q000502:physiology; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012016:Reference Values; D014280:Triglycerides / Q000378:metabolism
D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001056:Apolipoproteins C; D004967:Estrogens; D014280:Triglycerides