Receptor-Ck regulates membrane-bound 125 kDa protein having affinity for genomic sterol regulatory sequence.
The study addressed, to resolve the role of Receptor-Ck activation in the proteolytic maturation of 125 kDa (membrane bound) sterol regulatory element binding protein (SREBP), revealed that Receptor-Ck dependent signalling is not only responsible for the proteoloytic cleavage of this 125 kDa SREBP resulting in the generation of an active 47 kDa factor but also Receptor-Ck protein has high binding affinity for both 125 kDa SREBP as well as its cleaved 47 kDa product. Based upon these coupled with our earlier findings, we propose that Receptor-Ck may be regulating genes, have sterol regulatory element (SRE) in their promoter region, through the proteolytic maturation of 125 kDa SREBP into an active 47 kDa transcription factor.
Kaul
D
D
Department of Experimental Medicine and Biotechnology, Post Graduate Institute of Medical Science and Research, Chandigarh, India.
Kaur
M
M
D015153:Blotting, Western; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008954:Models, Biological; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D018110:Receptors, Lipoprotein / Q000235:genetics / Q000378:metabolism* / Q000502:physiology*; D015398:Signal Transduction; D051780:Sterol Regulatory Element Binding Protein 1; D013261:Sterols / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D018110:Receptors, Lipoprotein; C497387:SREBF1 protein, human; D051780:Sterol Regulatory Element Binding Protein 1; D013261:Sterols; D014157:Transcription Factors; C113493:receptor-Ck