title: 4-Hydroxycoumarin in heterocyclic synthesis. Part III. Synthesis of some new pyrano[2,3-d]pyrimidine, 2-substitute.
abstract: The synthesis of new [1]benzopyrano[3',4':5,6]pyrano[2,3-d]pyrimidines and related heterocycles has been reported. The key intermediate 2-amino-3-cyano-4-methyl-4H,5H-pyrano[3,2-c][1]benzopyran-5-one (3) was obtained in one pot synthesis from the reaction of 4-hydroxycoumarin and acetaldehyde-malononitrile (2). The antimicrobial screening was performed for some of the synthesized compounds.
authors.affiliation: Department of Chemistry, Faculty of Science, Al-Azhar University, Nasr City, Cairo, Egypt.
authors.forename: A H
authors.initials: AH
authors.lastname: Bedair
authors.forename: N A
authors.initials: NA
authors.lastname: El-Hady
authors.forename: A
authors.initials: A
authors.lastname: El-Latif
authors.forename: A H
authors.initials: AH
authors.lastname: Fakery
authors.forename: A M
authors.initials: AM
authors.lastname: El-Agrody
mesh_terms: D015110:4-Hydroxycoumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry* / Q000494:pharmacology; D003500:Cyclization; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D014227:Triazines / Q000737:chemistry* / Q000494:pharmacology
chemical_list: D015110:4-Hydroxycoumarins; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D003374:Coumarins; D011743:Pyrimidines; D014227:Triazines