title: Alterations in levels of various host antioxidant factors in turkey knockdown syndrome.
abstract: Five components (selenium, glutathione peroxidase, copper, superoxide dismutase, and vitamin E) of the antioxidant system of turkey poults were examined to determine if they play any role in the knockdown (KD) syndrome. All flocks were provided with feed formulated to contain monensin at 54-60 g/ton. Flock data were analyzed as a case-control study with three treatment groups (KD-affected and unaffected turkey poults from a KD flock and poults from an unaffected flock [control]). Affected turkey poults had lower (P < 0.001) serum vitamin E levels compared with unaffected poults from KD flocks or poults from unaffected flocks. No significant differences were observed for the other parameters evaluated but there was a trend towards lower copper and superoxide dismutase values in affected birds. It appears that serum vitamin E concentrations in turkey poults may play a significant role in susceptibility to or protection against KD syndrome. Other components of the antioxidant system may also be involved, and complex interactions among several body systems may be critical.
authors.affiliation: Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, Blacksburg 24061, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Meldrum
authors.forename: R D
authors.initials: RD
authors.lastname: Evans
authors.forename: J L
authors.initials: JL
authors.lastname: Robertson
authors.forename: K L
authors.initials: KL
authors.lastname: Watkins
authors.forename: M N
authors.initials: MN
authors.lastname: Novilla
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D003300:Copper / Q000097:blood; D004198:Disease Susceptibility; D005979:Glutathione Peroxidase / Q000097:blood; D007794:Lameness, Animal / Q000097:blood; D011201:Poultry Diseases / Q000097:blood*; D012643:Selenium / Q000097:blood; D013482:Superoxide Dismutase / Q000097:blood; D013577:Syndrome; D014422:Turkeys / Q000097:blood*; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D003300:Copper; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D012643:Selenium