title: Polycationic (mixed) core-shell dendrimers for binding and delivery of inorganic/organic substrates.
abstract: The convergent synthesis of a series of polycationic aryl ether dendrimers has been accomplished by a convenient procedure involving quantitative quaternarization of aryl(poly)amine core molecules. The series has been expanded to the preparation of the first polycationic, mixed core-shell dendrimer. All these dendrimers consist of an apolar core with a peripheral ionic layer which is surrounded by a less polar layer of dendritic wedges. These cationic, macromolecular species have been investigated for their ability to form assemblies with (anionic) guest molecules. The results obtained from UV/Vis and NMR spectroscopies, and MALDI-TOF-MS demonstrate that all the cationic sites throughout the dendrimer core are involved in ion pair formation with anionic guests giving predefined guest/host ratios up to 24. The large NMR spectroscopic shifts of resonances correlated with the groupings located in the core of the dendrimers, together with the relaxation time data indicate that the anionic guests are associated with the cationic core of these dendrimers. The X-ray molecular structure of the octacationic, tetra-arylsilane model derivative [Si(C6H3[CH2NMe3](2)-3,5)4]8+. 8I- shows that the iodide counterions are primarily located near the polycationic sphere. The new polycationic dendrimers have been investigated for their catalytic phase-transfer behavior and substrate delivery over a nanofiltration membrane.
authors.affiliation: Debye Institute, Department of Metal-Mediated Synthesis, Utrecht University, The Netherlands.
authors.forename: A W
authors.initials: AW
authors.lastname: Kleij
authors.forename: R
authors.initials: R
authors.lastname: van de Coevering
authors.forename: R J
authors.initials: RJ
authors.lastname: Klein Gebbink
authors.forename: A M
authors.initials: AM
authors.lastname: Noordman
authors.forename: A L
authors.initials: AL
authors.lastname: Spek
authors.forename: G
authors.initials: G
authors.lastname: van Koten