title: Experimental infection of colostrum deprived piglets with porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiates PCV2 replication.
abstract: Experimental infection of colostrum-deprived (CD) pigs with a combined inoculum of porcine circovirus 2 (PCV2) and porcine reproductive and respiratory syndrome virus (PRRSV) potentiated the replication and distribution of PCV2 virus, when compared with pigs inoculated with PCV2 alone. The replication and distribution of PRRSV in dually infected pigs was not enhanced, when compared to pigs inoculated with PRRSV alone. The mechanisms involved in the potentiation of PCV2 replication in PCV2/PRRSV and PCV2/porcine parvovirus (PPV) dually infected pigs may relate to the fact that monocyte/macrophage cell types are common targets of these 3 viruses.
authors.affiliation: Virology Department, Department of Agriculture and Rural Development for N. Ireland, Belfast.
authors.forename: G M
authors.initials: GM
authors.lastname: Allan
authors.forename: F
authors.initials: F
authors.lastname: McNeilly
authors.forename: J
authors.initials: J
authors.lastname: Ellis
authors.forename: S
authors.initials: S
authors.lastname: Krakowka
authors.forename: B
authors.initials: B
authors.lastname: Meehan
authors.forename: I
authors.initials: I
authors.lastname: McNair
authors.forename: I
authors.initials: I
authors.lastname: Walker
authors.forename: S
authors.initials: S
authors.lastname: Kennedy
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000032:analysis; D018173:Circoviridae Infections / Q000150:complications / Q000662:veterinary* / Q000821:virology; D017925:Circovirus / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D003126:Colostrum / Q000276:immunology; D005455:Fluorescent Antibody Technique; D019318:Porcine Reproductive and Respiratory Syndrome / Q000821:virology*; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D011897:Random Allocation; D013552:Swine; D013553:Swine Diseases / Q000821:virology*; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral