Acute effects on the human EEG after an external exposure to 200 ppm methanol.
OBJECTIVE
Even low concentrations of organic solvents may cause acute effects on the human central nervous system. The German MAK (threshold limit value) of methanol is 200 ppm. The aim of this study was to investigate whether acute exposure to 200 ppm methanol causes adverse effects, measured by EEG, and moreover, whether it is possible to differentiate between sedative and excitatory effects with this method.


METHODS
Twelve healthy subjects were exposed for 4 h to 200 ppm and to 20 ppm (control) in an exposure chamber in a cross-over design. The EEG was recorded before (reference) and at the end of each exposure with, the subject's eyes closed and opened and during a choice reaction test (color word stress test). Spectral power was calculated by fast Fourier transformation. Subjective symptoms and effects of blinding with 20 ppm methanol were assessed by questionnaires.


RESULTS
The study was a single-blind one. During subjects' exposure to 200 ppm, their scores for prenarcotic and irritating symptoms were not different from controls. In the closed-eye condition of subjects, the spectral power of the theta-band and of some electrodes of the delta-band was significantly less at the end of exposure to 200 ppm, than that of controls. In the open-eye condition and during the color word stress test no significant changes were found.


CONCLUSIONS
The changes in the theta-band suggest a slight excitatory effect of 200 ppm methanol. The effect was weak, as scores of acute symptoms did not change. With respect to our results, it is not necessary for the MAK value to be decreased.
Muttray
A
A
Institut für Arbeits-, Sozial- und Umweltmedizin der Johannes Gutenberg-Universität Mainz, Obere Zahlbacher Strasse 67, 55131 Mainz, Germany. amuttray@mail.uni-mainz.de
Kürten
R
R
Jung
D
D
Schicketanz
K H
KH
Konietzko
J
J
D000328:Adult; D002490:Central Nervous System / Q000187:drug effects* / Q000503:physiopathology; D018592:Cross-Over Studies; D004569:Electroencephalography; D006801:Humans; D019570:Inhalation Exposure / Q000032:analysis; D008297:Male; D000432:Methanol / Q000008:administration & dosage / Q000633:toxicity*; D012016:Reference Values; D016037:Single-Blind Method; D020711:Threshold Limit Values
D000432:Methanol