title: Infusional ECarboF in patients with advanced breast cancer: a very active and well-tolerated out-patient regimen.
abstract: We performed a trial using the combination of epirubicin 50 mg/m2/day 1, carboplatinum AUC 5/day 1 and continuous 5-fluorouracil (5-FU) 200 mg/m2/day (every 4 weeks for 6 months) to confirm the efficacy and low toxicity profile of this regimen in breast cancer. In 51 patients with metastatic (n = 33) or locally advanced (n = 18) breast cancer the overall response rate was 86% (95% confidence interval (95% CI): 73%-94%): 94% in locally advanced and 81% metastatic disease. Grade 3-4 toxicity was low: 4% of patients presented with febrile neutropenia, 16% with severe palmar-plantar syndrome, 10% with Port-a-cath thrombosis. This study confirms the high efficacy of infusional 5-FU-based regimens and justifies further research into novel promising oral 5-FU derivatives.
authors.affiliation: Division d'Oncologie, H pital Cantonal Universitaire de Genève, Switzerland. Anne.Huegli@hcuge.ch
authors.forename: A
authors.initials: A
authors.lastname: Hügli
authors.forename: A P
authors.initials: AP
authors.lastname: Sappino
authors.forename: S
authors.initials: S
authors.lastname: Anchisi
authors.forename: B
authors.initials: B
authors.lastname: Mermillod
authors.forename: P
authors.initials: P
authors.lastname: Schafer
authors.forename: J L
authors.initials: JL
authors.lastname: Anguenot
authors.forename: H
authors.initials: H
authors.lastname: Bonnefoi
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016190:Carboplatin / Q000008:administration & dosage; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007262:Infusions, Intravenous; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced
chemical_list: D015251:Epirubicin; D016190:Carboplatin; D005472:Fluorouracil