Heat-shock protein (HSP70-2) allelic frequencies in three distinct Mexican populations.
The major histocompatibility complex (MHC) genes are highly polymorphic and therefore have been useful in population genetics and disease association studies. We analyzed restriction fragment length polymorphism of HSP70-2 alleles in healthy unrelated Mestizo, Mazatecan and Nahua populations. Both Indian groups, Mazatecans and Nahuas, were in Hardy-Weinberg equilibrium, while Mestizos were in disequilibrium (chi 2 = 0.399; P < 0.05). The Mazatecan Indians presented a high frequency of BB homozygosity (17.35%) compared to Mestizos (5%) (P = 0.01). Mexican ethnic groups present differences in distribution of BB genotype. The low frequency of BB genotype in Mestizos may be the result of a negative selection process.
Zúñiga
J
J
Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15 Tlalpan 14000, México D.F., Mexico.
Vargas-Alarcón
G
G
Osnaya
N
N
Martínez-Tripp
S
S
Rodríguez-Reyna
T S
TS
Hernández-Martinez
B
B
Hesiquio
R
R
Hernández-Pacheco
G
G
Gamboa
R
R
Juárez
F
F
Salgado
N
N
Granados
J
J
D000483:Alleles; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008800:Mexico; D012150:Polymorphism, Restriction Fragment Length
D018840:HSP70 Heat-Shock Proteins