FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. I. Taxonomy, fermentation, isolation, physico-chemical properties and structure elucidation.
In the course of our screening for anti-influenza agents of microbial origin, FR191512 was isolated from the cultured broth of fungus strain No. 17415 as colorless powder. The structure of FR191512 was determined by several spectroscopic experiments as a novel polyphenolic compound. This compound showed potent antiviral activity against influenza A virus.
Nishihara
Y
Y
Fermentation Development Laboratories, Fujisawa Pharmaceutical Co, Ltd, Aichi, Japan.
Tsujii
E
E
Takase
S
S
Tsurumi
Y
Y
Kino
T
T
Hino
M
M
Yamashita
M
M
Hashimoto
S
S
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects*; D011091:Polyesters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012118:Resorcinols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000998:Antiviral Agents; C421166:FR 191512; D011091:Polyesters; D012118:Resorcinols