Immunohistochemical detection of the c-met proto-oncogene product in the congenital melanocytic nevus of an infant with neurocutaneous melanosis.
Transgenic mice overexpressing hepatocyte growth factor/scatter factor (HGF/SF) demonstrate extensive pigmented nevi in both skin and leptomeninges of the central nervous system resembling human neurocutaneous melanosis. We immunohistochemically detected HGF/SF receptor, Met, in a congenital nevus of an infant with neurocutaneous melanosis, indicating that deregulation of HGF/SF-Met signaling in the critical period of development may lead to this fatal syndrome.
Takayama
H
H
First Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan. hitakaya@showa.gunma-u.ac.jp
Nagashima
Y
Y
Hara
M
M
Takagi
H
H
Mori
M
M
Merlino
G
G
Nakazato
Y
Y
D000818:Animals; D002675:Child, Preschool; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008548:Melanosis / Q000235:genetics* / Q000276:immunology; D051379:Mice; D020752:Neurocutaneous Syndromes / Q000235:genetics* / Q000276:immunology; D009508:Nevus, Pigmented / Q000151:congenital* / Q000276:immunology / Q000473:pathology; D000090063:Proto-Oncogene Mas; D019859:Proto-Oncogene Proteins c-met / Q000032:analysis* / Q000276:immunology; D015398:Signal Transduction
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D019859:Proto-Oncogene Proteins c-met