Role of iron in Helicobacter pylori: its influence in outer membrane protein expression and in pathogenicity.
The acquisition of iron is a necessity for bacterial growth in Helicobacterpylori, as it is for other organisms. In addition, iron is a critical factor for the virulence of this organism. Therefore, it is not surprising that H. pylori isolates have the potential to express at least three major iron acquisition mechanisms. The association of H. pylori infection with host iron deficiency might indicate that the iron-scavenging systems play a role in the virulence of H. pylori.
Pérez-Pérez
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Department of Medicine, New York University, NY 10016, USA. guillermo.perez-perez@med.nyu.edu
Israel
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D001425:Bacterial Outer Membrane Proteins / Q000378:metabolism*; D015169:Colony Count, Microbial; D016481:Helicobacter Infections / Q000378:metabolism*; D016480:Helicobacter pylori / Q000378:metabolism* / Q000472:pathogenicity*; D006801:Humans; D007501:Iron / Q000032:analysis / Q000378:metabolism*; D012680:Sensitivity and Specificity
D001425:Bacterial Outer Membrane Proteins; D007501:Iron