[Safety and clinical efficiency of long-term complete blockade of renin-angiotensin-aldosterone system in patients with chronic obstructive pulmonary diseases].
OBJECTIVE
To study a corrective influence of a complete blockade of renin-angiotensin-aldosterone system (RAAS) on right ventricular failure in patients with chronic obstructive pulmonary diseases (COPD).


METHODS
91 COPD patients were randomised into 3 groups who received standard therapy (ST), ST + losartan, ST + losartan + aldactone. The duration of the follow-up was 24 months.


RESULTS
A complete RAAS blockade produced a significant decline in the pressure in the pulmonary artery, improved diastolic and systolic right ventricular function. This led to decreased number of hospitalizations because of progressing right ventricular failure.


CONCLUSIONS
Safety of therapy with ACE inhibitor and aldactone was proved by a comparison of the number of side effects in the three groups.
Arutiunov
G P
GP
Korsunskaia
M I
MI
Cherniavskaia
T K
TK
Vershinin
A A
AA
Rozanov
A V
AV
Balanina
N O
NO
D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D011446:Prospective Studies; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012449:Safety; D016896:Treatment Outcome; D016278:Ventricular Function, Right / Q000187:drug effects
D000806:Angiotensin-Converting Enzyme Inhibitors
Klinicheskaia éffektivnost' i bezopasnost' dlitel'noĭ kombinirovannoĭ blokady deĭstviia renin-angiotenzin-al'dosteronovoĭ sistemy u bol'nykh s khronicheskimi obstruktivnymi bolezniami legkikh.