Effects of corticosterone on connectin content and protein breakdown in rat skeletal muscle.
We examined the effects of a glucocorticoid, corticosterone, on calpain activity, connectin content and protein breakdown in rat muscle. The results indicated that calpain activity was increased by corticosterone and thus breakdown of connectin was stimulated followed by increased breakdown of skeletal muscle protein.
Hayashi
K
K
Department of Biochemical Science and Technology, Faculty of Agriculture, Kagoshima University, Japan.
Tada
O
O
Higuchi
K
K
Ohtsuka
A
A
D000818:Animals; D002154:Calpain / Q000187:drug effects / Q000378:metabolism; D064211:Connectin; D003345:Corticosterone / Q000494:pharmacology*; D008297:Male; D008762:Methylhistidines / Q000652:urine; D009124:Muscle Proteins / Q000187:drug effects / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000378:metabolism*; D011494:Protein Kinases / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D064211:Connectin; D008762:Methylhistidines; D009124:Muscle Proteins; D011494:Protein Kinases; D002154:Calpain; D003345:Corticosterone