[Study of the radioprotective effects of TMG on teratogenic malformations in irradiated mice].
ICR mice fetuses in the organogenesis stage were used to clarify experimentally the mechanism of the protective effect of vitamin E derivant (TMG: 2-(alpha-D-Glucopyranosyl) methyl-2, -5, -7, -8-Teramethylchorman-6-working woman) on the effects of radiation. The authors paid careful attention to radiation, and the radioprotective effects of TMG on the induction of malformations was examined. Radiation is an important consideration because of its widespread use in the areas of medicine, nuclear energy, and industry. Malformations induced by radiation at the organogenesis stage, skeletal malformations, and the effects at the cellular level of embryos were examined in this research. Further, the mechanism of the protection effect of TMG against radiation-induced malformations was analyzed and observed experimentally. Thus, this study was done to provide fundamental data on the radioprotective agent TMG. It was clear that TMG exerted radioprotective effects against embryonic death and the rate of teratogenesis when administered before exposure. Such effects were also exerted against skeletal malformations and fetal body weight. In summary, radioprotective effects were observed at the whole-body level as well as at the cellular level.
Gu
Y
Y
Department of Radiological Technology, Suzuka University of Medical Science.
Hasegawa
T
T
Kim
H
H
Suzuki
I
I
Mori
T
T
Yamamoto
Y
Y
D000016:Abnormalities, Radiation-Induced / Q000196:embryology / Q000517:prevention & control*; D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000528:radiation effects; D001755:Blastocyst / Q000187:drug effects / Q000528:radiation effects; D002839:Chromans / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005313:Fetal Death / Q000517:prevention & control; D016166:Free Radical Scavengers / Q000494:pharmacology* / Q000627:therapeutic use; D005854:Germ Cells / Q000166:cytology; D006027:Glycosides / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009024:Morphogenesis / Q000187:drug effects / Q000528:radiation effects; D009139:Musculoskeletal Abnormalities / Q000196:embryology / Q000517:prevention & control; D011247:Pregnancy; D011829:Radiation Dosage; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use
C106323:2-(glucopyranosyl)methyl-2,5,7,8-tetramethylchroman-6-ol; D002839:Chromans; D016166:Free Radical Scavengers; D006027:Glycosides; D011837:Radiation-Protective Agents