title: Synthesis of 5-substituted pyrrolo[1,2-b]pyridazines with antioxidant properties.
abstract: 5-Substituted pyrrolo[1,2-b]pyridazines have been prepared by cyclisation of pyridazine with diphenylcyclopropenone followed by further functionalisations in the pyrrolo[1,2-b]pyridazine 5-position. Several compound exhibit profound inhibition of lipid peroxidation in vitro. Lipid peroxidation of boiled rat liver microsomes was induced by ascorbic acid/FeSO4 and the peroxidation was determined by measuring the thiobarbituric acid reactive material.
authors.affiliation: Department of Chemistry, University of Oslo, P.O. Box 1033, Blindern, N-0315 Oslo, Norway.
authors.forename: O B
authors.initials: OB
authors.lastname: Østby
authors.forename: L L
authors.initials: LL
authors.lastname: Gundersen
authors.forename: F
authors.initials: F
authors.lastname: Rise
authors.forename: O
authors.initials: O
authors.lastname: Antonsen
authors.forename: K
authors.initials: K
authors.lastname: Fosnes
authors.forename: V
authors.initials: V
authors.lastname: Larsen
authors.forename: A
authors.initials: A
authors.lastname: Bast
authors.forename: I
authors.initials: I
authors.lastname: Custers
authors.forename: G R
authors.initials: GR
authors.lastname: Haenen
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D003500:Cyclization; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology*; D051381:Rats; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D000975:Antioxidants; D011724:Pyridazines; D011758:Pyrroles; D017392:Thiobarbituric Acid Reactive Substances