title: Transient hyperthyroidism following L-asparaginase therapy for acute lymphoblastic leukemia.
abstract: The effect of L-asparaginase on the thyroid gland has not been well documented. We report the first two cases of hyperthyroidism associated with thyroid nodule following L-asparaginase therapy for acute lymphoblastic leukemia (ALL). The thyroid function abnormalities were not severe, short-lived and did not require specific therapy.
authors.affiliation: Department of Haematology and Transplantation, MAKNA-HUKM Cancer Institute, Hospital Universiti Kebangsaan Malaysia, Jalan Tenteram, Cheras, 56000 Kuala Lumpur.
authors.forename: S A
authors.initials: SA
authors.lastname: Fadilah
authors.forename: I
authors.initials: I
authors.lastname: Faridah
authors.forename: S K
authors.initials: SK
authors.lastname: Cheong
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents; D001215:Asparaginase