An imidazoline pseudodipeptide suitable for solid phase peptide synthesis.
This paper describes the synthesis of two diastereoisomers of an imidazoline dipeptide mimetic (a 4,5 dihydroimidazole-4-carboxylic acid), suitably protected for incorporation into solid phase peptide synthesis (SPPS) using the Fmoc protocol, from a phenylalanine-derived thioimidate and an alpha,beta-diaminopropanoic acid ester, followed by protecting group manipulation.
Jones
R C
RC
Chemistry Department, The Open University, Milton Keynes, UK. r.c.f.jones@lboro.ac.uk
Dickson
J
J
D004151:Dipeptides / Q000737:chemistry*; D007093:Imidazoles / Q000737:chemistry*; D008956:Models, Chemical; D015394:Molecular Structure; D010446:Peptide Fragments / Q000096:biosynthesis*
D004151:Dipeptides; D007093:Imidazoles; D010446:Peptide Fragments