title: [Genomic medicine in the solution of pulmonological problems].
abstract: Main points of the new direction genomic medicine and its applications to solution of pulmonological problems are outlined. Information on the molecular epidemiology of cystic fibrosis and bronchial asthma is presented. The frequency of major cystic fibrosis gene mutations and bronchial asthma candidate gene polymorphisms was defined in Siberian populations. The familial case histories of patients with bronchial asthma were used to assess the contribution of interleukine (IL4, IL5, IL9) and nitric oxide synthase (NOS3) genes to susceptibility to bronchial asthma.
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
authors.forename: L M
authors.initials: LM
authors.lastname: Ogorodova
mesh_terms: D001249:Asthma / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D003550:Cystic Fibrosis / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D023281:Genomics / Q000379:methods*; D006801:Humans; D015994:Incidence; D007378:Interleukins / Q000235:genetics / Q000378:metabolism; D017720:Molecular Epidemiology / Q000379:methods*; D009154:Mutation; D019001:Nitric Oxide Synthase / Q000235:genetics / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III; D012800:Siberia / Q000453:epidemiology
chemical_list: D007378:Interleukins; C496314:NOS3 protein, human; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III
vernacular_title: Genomnaia meditsina v reshenii problem pul'monologii.