title: [Disruption of microbiocenosis of the large intestine and the immune and interferon status in children with bacterial complications of acute viral infections of the respiratory tract and their correction by high doses of bifidumbacterin forte].
abstract: One hundred and twenty-nine children with acute viral and bacterial infection of the respiratory tract were examined and disturbance of the large intestine microflora was detected. It was characterized by significant reduction of lactobacilli, moderate growth of opportunistic bacteria and higher contents of Candida. Changes in T- and especially B-cellular immunity were observed in 35 per cent of the patients. In patients with decreased avidity of the immunoglobulins G in the peripheral blood the changes were observed in 82-100 per cent of the cases. In the majority of the patients the capacity for interferon genesis was suppressed. A shorten course (5 days) of the bifidumbacterin forte therapy in a dose of not less than 10(9) CFU/ml. normalized the intestinal microflora, improved the indices of the B- and T-cellular immunity (including the subpopulation of the T-helper cells but not the T-suppressor cells), stimulated NK and improved the ability to induce alfa- and gamma-interferons of the peripheral blood leukocytes. The experience with using high doses of bifidumbacterin forte was evident of its good tolerance and possible value in increasing the patient resistance to infection.
authors.affiliation: Central Clinical Hospital, Medical Centre of Managing Department of the President of the Russian Federation, Moscow.
authors.forename: E A
authors.initials: EA
authors.lastname: Lykova
authors.forename: A A
authors.initials: AA
authors.lastname: Vorob'ev
authors.forename: A G
authors.initials: AG
authors.lastname: Bokovoĭ
authors.forename: I N
authors.initials: IN
authors.lastname: Pobedinskaia
authors.forename: V S
authors.initials: VS
authors.lastname: Gevondian
authors.forename: N M
authors.initials: NM
authors.lastname: Gevondian
authors.forename: S D
authors.initials: SD
authors.lastname: Mitrokhin
authors.forename: V I
authors.initials: VI
authors.lastname: Minaev
authors.forename: N B
authors.initials: NB
authors.lastname: Dzis
authors.forename: L F
authors.initials: LF
authors.lastname: Makkaveeva
authors.forename: I V
authors.initials: IV
authors.lastname: Kovalev
authors.forename: A O
authors.initials: AO
authors.lastname: Murashova
authors.forename: V M
authors.initials: VM
authors.lastname: Bondarenko
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000917:Antibody Formation; D001407:Bacillus; D001424:Bacterial Infections / Q000209:etiology / Q000276:immunology* / Q000382:microbiology / Q000628:therapy*; D001688:Biological Products / Q000627:therapeutic use*; D002175:Candida / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007111:Immunity, Cellular; D007223:Infant; D007372:Interferons / Q000096:biosynthesis*; D007420:Intestine, Large / Q000382:microbiology*; D007778:Lactobacillus / Q000302:isolation & purification; D019936:Probiotics / Q000627:therapeutic use*; D012141:Respiratory Tract Infections / Q000150:complications*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001688:Biological Products; C010546:bifidobacterin; D007372:Interferons
vernacular_title: Narusheniia mikrobiotsenoza tolstoĭ kishki, immunnogo i interferonovogo statusa u deteĭ s bakterial'nymi oslozhneniiami ORVI i rezul'taty ikh korrektsii bol'shimi dozami bifidumbakterina forte.