title: Eudragit matrices for sustained release of ketorolac tromethamine: formulation and kinetics of release.
abstract: Matrix type formulations with dicalcium phosphate dihydrate (DCPD) using a polymeric binder (Eudragit RSPM) to obtain controlled release of Ketorolac tromethamine (KT) has been investigated. The drug, DCPD and Eudragit RSPM were granulated using isopropyl alcohol with and without a plasticizer (Diethyl phthalate, DEP). Addition of Eudragit appear to affect the release profile. However, addition of a plasticizer had a significant effect on the rate of release. The release appears to follow first order kinetics and the rate constant decreased linearly with increasing DEP concentration. A directly compressible mixture was also formulated by coating DCPD particles with DEP with and without Eudragit RSPM.
authors.affiliation: Periyar College of Pharmaceutical Sciences for Girls, Trichy-21.
authors.forename: K
authors.initials: K
authors.lastname: Ruckmani
authors.forename: M S
authors.initials: MS
authors.lastname: Muneera
authors.forename: R
authors.initials: R
authors.lastname: Vijaya
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D005079:Excipients; D020911:Ketorolac Tromethamine / Q000008:administration & dosage*; D007700:Kinetics; D010968:Plasticizers; D011109:Polymethacrylic Acids; D012995:Solubility; D013607:Tablets
chemical_list: D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D005079:Excipients; D010968:Plasticizers; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D020911:Ketorolac Tromethamine