Bicyclic nucleoside inhibitors of Varicella-Zoster Virus (VZV): the effect of terminal unsaturation in the side chain.
Novel bicyclic nucleoside analogues bearing long alkyl side chains are prepared and tested as inhibitors of VZV. In particular, analogues with terminal unsaturation in the side chain are reported. Whilst terminal alkenyl derivatives are potent antivirals, the corresponding terminal alkynyls are poorly active.
Srinivasan
S
S
Welsh School of Pharmacy, Cardiff University, King Edward, Cardiff, UK.
McGuigan
C
C
Andrei
G
G
Snoeck
R
R
De Clercq
E
E
Balzarini
J
J
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000138:chemical synthesis / Q000494:pharmacology*; D002460:Cell Line / Q000166:cytology / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D014645:Herpesvirus 3, Human / Q000187:drug effects*; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D009705:Nucleosides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D019086:Bridged Bicyclo Compounds, Heterocyclic; D009705:Nucleosides