title: A method to incorporate leakage and head scatter corrections into a tomotherapy inverse treatment planning algorithm.
abstract: A detailed tomotherapy inverse treatment planning method is described which incorporates leakage and head scatter corrections during each iteration of the optimization process, allowing these effects to be directly accounted for in the optimized dose distribution. It is shown that the conventional inverse planning method for optimizing incident intensity can be extended to include a 'concurrent' leaf sequencing operation from which the leakage and head scatter corrections are determined. The method is demonstrated using the steepest-descent optimization technique with constant step size and a least-squared error objective. The method was implemented using the MATLAB scientific programming environment and its feasibility demonstrated for 2D test cases simulating treatment delivery using a single coplanar rotation. The results indicate that this modification does not significantly affect convergence of the intensity optimization method when exposure times of individual leaves are stratified to a large number of levels (>100) during leaf sequencing. In general, the addition of aperture dependent corrections, especially 'head scatter', reduces incident fluence in local regions of the modulated fan beam, resulting in increased exposure times for individual collimator leaves. These local variations can result in 5% or greater local variation in the optimized dose distribution compared to the uncorrected case. The overall efficiency of the modified intensity optimization algorithm is comparable to that of the original unmodified case.
authors.affiliation: University of Maryland, School of Medicine, Radiation Oncology Department, Baltimore 21201-1595, USA. tholm002@umaryland.edu
authors.forename: T W
authors.initials: TW
authors.lastname: Holmes
mesh_terms: D000465:Algorithms; D004307:Dose-Response Relationship, Radiation; D008962:Models, Theoretical; D011880:Radiotherapy Planning, Computer-Assisted / Q000379:methods*; D020266:Radiotherapy, Conformal / Q000379:methods*; D012542:Scattering, Radiation; D013997:Time Factors