[Effect of therapy with blood component (activated autoplasma) on blood glutathione level in patients with vascular abnormalities on the fundus oculi].
Thirty-three patients with central chorioretinal dystrophy, 18 with proliferative diabetic retinopathy, and 15 controls without ocular diseases were examined. All patients were treated by blood components. The treatment started with activation of blood plasma platelets. Glutathione was measured in two portions of plasma: intact and containing platelet activation products. The content of glutathione was higher in activated autoplasma of 21 patients with central chorioretinal dystrophy and 6 patients with diabetic retinopathy than in intact plasma by 107 and 72%, respectively. A decrease in glutathione level in activated autoplasma was observed in 1 patient with central chorioretinal dystrophy and in 9 with diabetic retinopathy. Hence, antioxidant defense is decreased in diabetic retinopathy, since glutathione is involved in reduction of organic hydroperoxides.
Filina
A A
AA
Mukha
A I
AI
Lysenko
V S
VS
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016913:Blood Component Transfusion / Q000379:methods*; D001804:Blood Transfusion, Autologous; D015862:Choroid Diseases / Q000097:blood / Q000628:therapy*; D003930:Diabetic Retinopathy / Q000097:blood / Q000628:therapy*; D005654:Fundus Oculi; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D010949:Plasma; D011379:Prognosis; D012162:Retinal Degeneration / Q000097:blood / Q000628:therapy*
D015415:Biomarkers; D005978:Glutathione
Vliianie gemokomponentnoĭ terapii (aktivirovannoĭ autoplazmy) na uroven' glutationa v krovi u bol'nykh s sosudistoĭ patologieĭ glaznogo dna.