Sustained release of mitomycin-C from poly(DL-lactide) /poly(DL-lactide-co-glycolide) films.
Mitomycin-C (MMC)-loaded poly(DL-lactide) (PLA)/poly(DL-lactide-co-glycolide) (PLGA) films which have different drug loading capacities and thicknesses were prepared by a solvent-evaporation technique. Degradation and release studies were conducted at 37 degrees C in pH 7.4 phosphate buffered saline. The results showed that both the rate and the percentage of released MMC increased as the glycolide content in the copolymer increased from 10 to 30% (w/w) and the drug load increased from 0.5 to 2 mg MMC per 300 mg of polymer. In contrast, they decreased depending upon increasing film thickness from 80 to 300 microm and polymer molecular weight. It was found that the drug release mechanism is diffusion-controlled according to a non-Fickian diffusion mechanism.
Gümüşderelioglu
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M
Hacettepe University, Chemical Engineering Department, Ankara, Turkey. menemse@hacettepe.edu.tr
Deniz
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G
D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics; D001672:Biocompatible Materials / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D019344:Lactic Acid / Q000737:chemistry*; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016685:Mitomycin / Q000493:pharmacokinetics*; D011091:Polyesters / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D001672:Biocompatible Materials; D011091:Polyesters; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; C033616:poly(lactide); D016685:Mitomycin