The pharmacokinetics of subcutaneous enoxaparin in end-stage renal disease.
OBJECTIVE
To evaluate the pharmacokinetics of enoxaparin in end-stage renal disease (ESRD), and determine if dosage reduction is necessary to maintain antifactor Xa activity concentrations within the therapeutic range.


METHODS
Prospective, single-dose pharmacokinetic study.


METHODS
University-affiliated general clinical research center.


METHODS
Eight nonthrombosed patients with ESRD requiring hemodialysis.


METHODS
All subjects received a single dose of enoxaparin sodium 1 mg/kg subcutaneously and had serial plasma antifactor Xa activity concentrations measured over 24 hours.


RESULTS
The pharmacokinetics of enoxaparin were determined from plasma antifactor Xa activity concentrations, and various multiple-dose regimens were simulated. After administration of the drug, total body clearance was 14.6 ml/minute and there was a 2-fold prolongation in antifactor Xa activity half-life compared with values reported in healthy subjects. All other pharmacokinetic parameters were similar to those in healthy subjects and patients with chronic renal insufficiency. An accumulation ratio of 1.6 was estimated for a dosing interval of every 12 hours based on single-dose pharmacokinetics. When various therapeutic regimens were simulated to predict average steady-state antifactor Xa activity, standard enoxaparin dosages of 1 mg/kg subcutaneously every 12 hours and 1.5 mg/kg every 24 hours resulted in average steady-state concentrations within the therapeutic range.


CONCLUSIONS
Based on antifactor Xa activity, ESRD has little effect on the pharmacokinetics of enoxaparin, and dosing adjustments are unnecessary.
Brophy
D F
DF
Department of Primary Care, Hunter Holmes McGuire Veterans Affairs Medical Center, Richmond, Virginia 23249, USA.
Wazny
L D
LD
Gehr
T W
TW
Comstock
T J
TJ
Venitz
J
J
D000328:Adult; D000925:Anticoagulants / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D017984:Enoxaparin / Q000097:blood / Q000493:pharmacokinetics*; D015951:Factor Xa / Q000378:metabolism*; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
D000925:Anticoagulants; D017984:Enoxaparin; D015951:Factor Xa