Myoblast transplantation for heart failure.
Intramyocardial skeletal muscle transplantation has been shown experimentally to improve heart function after infarction. We report success with this procedure in a patient with severe ischaemic heart failure. We implanted autologous skeletal myoblasts into the postinfarction scar during coronary artery bypass grafting of remote myocardial areas. 5 months later, there was evidence of contraction and viability in the grafted scar on echocardiography and positron emission tomography. Although this result is encouraging, it requires validation by additional studies.
Menasché
P
P
Hagège
A A
AA
Scorsin
M
M
Pouzet
B
B
Desnos
M
M
Duboc
D
D
Schwartz
K
K
Vilquin
J T
JT
Marolleau
J P
JP
D000368:Aged; D001757:Blastomeres / Q000637:transplantation*; D002303:Cardiac Output, Low / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D004452:Echocardiography; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000166:cytology*; D009203:Myocardial Infarction / Q000150:complications*; D014055:Tomography, Emission-Computed; D014182:Transplantation, Autologous