[The effect of polylactide screws on fracture healing].
This experiment aimed at investigating the effect of a kind of home-bred poly-DL-lactide screws on fracture healing. An operation was performed so as to make bilateral lateral condylar fractures of the femur in 8 dogs. The left sides were fixed with 2 home-bred PDLLA(Mv = 43 x 10(4)) screws, and the contralateral sides were fixed with 2 metalic screws to be used as controls. The animals were sacrificed at 2, 4, 8, and 12 weeks after surgery. Optic microscopy and SEM photography were done. The results of optic microscopy showed that fibrous callus formed already in both groups by 2 weeks after surgery, and bilateral fractures united uneventfully by 12 weeks. Although the course of fracture healing in experimental group was slower than that in control group, the osteogenesis in experimental group appeared to be normal. The SEM examination demonstrated that collagenous fibers arranged regularly and calcified normally in both groups at 12 weeks. And many square and rhomboid granules produced from the degradation of PDLLA material were found in experimental group at 12 weeks. Therefore, it is suggested that this kind of home-bred PDLLA screws should be applicable to fractures where the tissues are rich in blood supply.
Duan
H
H
Department of Orthopedics, 1st University Hospital, WCUMS, Chengdu 610041.
Song
Y
Y
Peng
Z
Z
Liu
L
L
Xiong
C
C
Zhang
X
X
Luo
F
F
Zhu
X
X
Lin
D
D
D000818:Animals; D001672:Biocompatible Materials; D001863:Bone Screws; D004285:Dogs; D005264:Femoral Fractures / Q000473:pathology / Q000601:surgery; D005593:Fracture Fixation, Internal / Q000295:instrumentation; D017102:Fracture Healing; D011091:Polyesters
D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)