[Concentration of isepamicin sulfate in bone marrow blood].
Fifteen patients who were performed a rotator cuff repair were subjected for the determination of a concentration of isepamicin sulfate (ISP), which was infused intravenously, in venous blood and bone marrow blood. The concentrations were measured at 0, 30, 60 minutes after the injection. There was no statistically significance between ISP concentrations in venous and bone marrow blood. This study revealed that the transference of ISP to the bone marrow was excellent.
Shibata
Y
Y
Department of Orthopedics, Fukuoka University.
Midorikawa
K
K
Naito
M
M
Yatsunami
M
M
Hamada
K
K
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001692:Biological Transport; D001853:Bone Marrow / Q000378:metabolism*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D017006:Rotator Cuff / Q000601:surgery; D000070636:Rotator Cuff Injuries; D013530:Surgical Wound Infection / Q000517:prevention & control; D013997:Time Factors
D000900:Anti-Bacterial Agents; D005839:Gentamicins; C016927:isepamicin