Intracellular surveillance: controlling the assembly of MHC class I-peptide complexes.
MHC class I molecules bind with high affinity to peptides in the endoplasmic reticulum and display them on the cell surface. Here they are screened by CD8-positive T-lymphocytes for the presence of foreign, pathogen-derived peptides within the mass of self-peptides expressed. MHC class I assembly is a complicated process involving a number of accessory molecules, including specialized components as well as common chaperones. Our understanding of the mechanisms involved, while quite advanced, is far from complete.
Cresswell
P
P
Howard Hughes Medical Institute, Yale University School of Medicine, 310 Cedar Street, New Haven, CT 06510, USA. peter.cresswell@yale.edu
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism; D010455:Peptides / Q000737:chemistry* / Q000378:metabolism; D021381:Protein Transport
D015395:Histocompatibility Antigens Class I; D018832:Molecular Chaperones; D010455:Peptides