title: Outbreak of aseptic meningitis by echo 4: prevalence of clinical cases among adults.
abstract: Twenty five cases of meningitis occurred in urban areas surrounding a city (Modena) in Northern Italy, in the period May-July 1999. When the patients were admitted to the Infectious Diseases Division of the University of Modena and Reggio Emilia Hospital and studied by virological and serological methods, the meningitis proved to have an enteroviral origin and enterovirus ECHO 4 type was responsible for all cases of illness. An epidemiological characteristic of the enteroviral meninigitis outbreak was the adult age in 23 out of the 25 patients (mean age 24.50 +/- 7.84 years). The monthly distribution of the aseptic meningitis cases was the following: five cases occurred in May, 13 in June and seven in July. The origin of the spread of the virus infection and the reason for its sudden end remained unknown. The unusual drop in temperature which occurred in the geographic area involved in the aseptic meningitis outbreak at the beginning of August could have interfered with the slowdown in virus circulation.
authors.affiliation: Department of Hygiene, Microbiology and Biostatistics, Center for Diagnosis of Viral Diseases.
authors.forename: M
authors.initials: M
authors.lastname: Portolani
authors.forename: M
authors.initials: M
authors.lastname: Pecorari
authors.forename: P
authors.initials: P
authors.lastname: Pietrosemoli
authors.forename: A
authors.initials: A
authors.lastname: Bartoletti
authors.forename: A M
authors.initials: AM
authors.lastname: Sabbatini
authors.forename: M
authors.initials: M
authors.lastname: Meacci
authors.forename: W
authors.initials: W
authors.lastname: Gennari
authors.forename: E
authors.initials: E
authors.lastname: Bazzani
authors.forename: F
authors.initials: F
authors.lastname: Beretti
authors.forename: G
authors.initials: G
authors.lastname: Guaraldi
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral / Q000032:analysis; D002648:Child; D002522:Chlorocebus aethiops; D004196:Disease Outbreaks; D004457:Echovirus Infections / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000821:virology*; D029822:Enterovirus B, Human / Q000235:genetics / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000821:virology; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008582:Meningitis, Aseptic / Q000134:cerebrospinal fluid / Q000453:epidemiology* / Q000821:virology*; D016133:Polymerase Chain Reaction; D015995:Prevalence; D014709:Vero Cells / Q000821:virology
chemical_list: D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral