title: Clinical assessment of unilateral pulmonary artery occlusion test with dobutamine infusion. Expansion of surgical indications in patients with primary lung cancer and impaired cardiopulmonary functions.
abstract: OBJECTIVE
  We evaluated the possibility of expanding indications for pulmonary resection based on an assessment of the pressure-flow relationship in pulmonary circulation.
  
  
  METHODS
  In 6 of 28 lung cancer patients whose total pulmonary vascular resistance index exceeded the threshold during unilateral pulmonary artery occlusion testing, we conducted unilateral pulmonary artery occlusion testing with dobutamine administration, followed by lung resection. We studied hemodynamics during testing and derived a new indication for pulmonary resection from the postoperative course.
  
  
  RESULTS
  Cardiac output was 3.82 +/- 0.74 l/min before testing, 3.66 +/- 0.76 l/min during pulmonary artery occlusion testing, and 5.92 +/- 1.78 l/min during unilateral pulmonary artery occlusion testing with dobutamine infusion. The total pulmonary vascular resistance index was 890 +/- 350 dyne.sec.cm-5.m2 before testing, 1170 +/- 320 dyne.sec.cm-5.m2 during testing, and 800 +/- 160 dyne.sec.cm-5.m2 during testing with dobutamine infusion. Cardiac output increased (p = 0.014) during unilateral pulmonary artery occlusion testing with dobutamine infusion, and the total pulmonary vascular resistance index significantly decreased (p = 0.034). Of the 4 patients eligible for lobectomy, 2 underwent the procedure--one undergoing segmentectomy in which pulmonary metastasis was found during surgery and the other undergoing radiotherapy for cN2 disease with chest wall invasion. Of the 2 initially ineligible for lobectomy, one underwent partial pulmonary resection and the other underwent lobectomy because the total pulmonary vascular resistance index was less than 800 dyne.sec.cm-5.m2 during selective pulmonary artery occlusion testing with dobutamine infusion, indicating eligibility for lobectomy. No severe complications of cardiopulmonary function failure after surgery occurred in any of the 5 cases.
  
  
  CONCLUSIONS
  Unilateral pulmonary artery occlusion testing with dobutamine infusion is useful in determining patient eligibility for pulmonary resection.
authors.affiliation: Department of Surgery I, Tokyo Women's Medical University, School of Medicine, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Onuki
authors.forename: M
authors.initials: M
authors.lastname: Nishiuchi
authors.forename: M
authors.initials: M
authors.lastname: Kanzaki
authors.forename: S
authors.initials: S
authors.lastname: Nitta
mesh_terms: D000368:Aged; D001794:Blood Pressure; D002302:Cardiac Output; D004280:Dobutamine; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D007261:Infusions, Intra-Arterial; D008175:Lung Neoplasms / Q000503:physiopathology / Q000601:surgery*; D008875:Middle Aged; D010991:Plethysmography; D011013:Pneumonectomy / Q000379:methods*; D011651:Pulmonary Artery / Q000502:physiology; D011652:Pulmonary Circulation; D014655:Vascular Resistance
chemical_list: D004280:Dobutamine