Oral mature teratoma containing epididymal tissue in a female neonate.
We describe a female neonate with an oral teratoma showing bone, teeth, and epidermis, but also epididymal (male) tissue. PCR amplification of Y-chromosomal DNA clearly showed male DNA from paraffin-embedded tumour tissue. The girl had a normal female karyotype without abnormalities of the genital organs. There are at least three hypotheses for the origin of teratomas: parthenogenesis, incomplete twinning, and totipotent somatic-cell origin. This case supports the hypothesis of an included dizygotic twin, and might contribute to the elucidation of the pathogenesis of extragonadal teratomas.
Beutel
K
K
Partsch
C J
CJ
Jänig
U
U
Nikischin
W
W
Suttorp
M
M
D004247:DNA / Q000032:analysis; D004822:Epididymis / Q000473:pathology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D009062:Mouth Neoplasms / Q000196:embryology / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D013724:Teratoma / Q000196:embryology / Q000235:genetics / Q000473:pathology*; D014998:Y Chromosome / Q000235:genetics
D004247:DNA