title: Hypoglycaemic activity of extracts from soft corals of Andaman and Nicobar coasts in rats.
abstract: The ethylacetate extract of soft corals collected from Andaman and Nicobar Coasts were screened for hypoglycaemic activity in fasting rats. Rats were divided into 5 groups. Group I received 0.5 ml of 5% gum acacia suspension (control). Group II received the extract of Cladiella australis (CAS), at a dose of 250 mg/kg. Group III received the extract of Sinularia new species (SNS), at a dose of 75 mg/kg. Group IV received the extract of Lamnalia new species (LNS), at a dose of 400 mg/kg and Group V received the extract of 250MF-CBR-13 at a dose of 250 mg/kg. All extracts were administered orally. Blood samples, collected before the administration of test extracts and also at 2, 4, 6, and 8 hr after treatment, were analysed for glucose content. The percentage blood glucose reduction from that of control was also calculated. A very promising hypoglycaemic activity was observed in rats with CAS at 8 hr (42.3%), with SNS at 4 hr (28.34%) and 6 hr (40.6%), with LNS at 6 hr (32.38%) and with MF-CBR-13 at 6 hr (20.25%).
authors.affiliation: Department of Pharmaceutical Sciences, Andhra University, Visakhapatnam 530 003, India.
authors.forename: S
authors.initials: S
authors.lastname: Satyanarayana
authors.forename: D
authors.initials: D
authors.lastname: Satyavati
authors.forename: D V
authors.initials: DV
authors.lastname: Rao
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003063:Cnidaria / Q000737:chemistry*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007004:Hypoglycemic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D007194:India; D008297:Male; D051381:Rats
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents