title: Vasospastic angina accompanied by Brugada-type electrocardiographic abnormalities.
abstract: Brugada Syndrome and Vasospastic Angina. We present two patients with vasospastic angina and Brugada-type ECG abnormalities. The first patient complained of chest pain, and transient ST segment elevation was confirmed on ECG. Coronary angiogram showed no organic stenosis. The second patient had syncopal episodes following anginal chest pain, and the same symptoms were reproduced by intracoronary acetylcholine injection that induced vasospasm. In both patients, ECG at rest showed ST segment elevation in leads V1 and V2 and a right bundle branch block pattern that were accentuated by a Class I antiarrhythmic drug. Ventricular fibrillation also was induced by programmed electrical stimulation. Susceptibility to ventricular fibrillation can be modulated by the interaction of coronary vasospasm with Brugada syndrome or vice versa; therefore, it is important to study the clinical implications of the coexistence of the two diseases in such patients.
authors.affiliation: First Department of Internal Medicine, Niigata University School of Medicine, Japan. chinushi@med.niigata-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Chinushi
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroe
authors.forename: E
authors.initials: E
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Tagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Aizawa
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000209:etiology*; D002037:Bundle-Branch Block / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology; D002304:Cardiac Pacing, Artificial; D003329:Coronary Vasospasm / Q000150:complications*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D014693:Ventricular Fibrillation / Q000209:etiology