title: Fatty acid substituted polyvinyl alcohol as a supporting material for microsphere preparation.
abstract: Polyvinyl alcohol, substituted with lauric, myristic, palmitic, and stearic acids at different substitution degrees was employed for the preparation of biodegradable microspheres containing progesterone or indomethacin. A solvent extraction/method was followed, starting from an oil-in-water dispersion containing the polymer and drug in the inner phase. Microspheres were obtained with high loading efficiency, whose release properties were dependent on the nature of the acyl substituent and the substitution degree. Kinetics approaching zero-order were obtained for the most hydrophile microspheres such as those based on the least substituted polymers and lowest molecular weight substituents. The hydrophilicity of these systems hindered protein absorption on their surface, suggesting their suitability for parenteral use.
authors.affiliation: Deparment of Pharmaceutical Sciences, Bologna University, Italy. orienti@biocfarm.unibo.it
authors.forename: I
authors.initials: I
authors.lastname: Orienti
authors.forename: G
authors.initials: G
authors.lastname: Zuccari
authors.forename: B
authors.initials: B
authors.lastname: Luppi
authors.forename: V
authors.initials: V
authors.lastname: Zecchi
mesh_terms: D000327:Adsorption; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000493:pharmacokinetics; D002021:Buffers; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004058:Diffusion; D005079:Excipients; D005227:Fatty Acids / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D007213:Indomethacin / Q000008:administration & dosage / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism; D008863:Microspheres; D008970:Molecular Weight; D010316:Particle Size; D011142:Polyvinyl Alcohol / Q000737:chemistry*; D011374:Progesterone / Q000008:administration & dosage / Q000493:pharmacokinetics
chemical_list: D000893:Anti-Inflammatory Agents; D002021:Buffers; D005079:Excipients; D005227:Fatty Acids; D011374:Progesterone; D011142:Polyvinyl Alcohol; D007213:Indomethacin