title: [Ischemic heart disease and metabolic syndrome X (family study)].
abstract: OBJECTIVE
  To evaluate prevalence of metabolic syndrome "X" (MS) components in the families of probands and their wives regarding the presence of hyperinsulinemia and in probands' children of both sexes regarding their having vegetovascular dystonia.
  
  
  METHODS
  92 families were selected by the proband who survived acute myocardial infarction (MI) at the age under 50: 92 probands (mean age 47 +/- 1.1 years), 57 probands' wives (mean age 47 +/- 0.7 years), 20 sons (mean age 18.3 +/- 0.8 years), 24 daughters (mean age 19.1 +/- 1.0 years). Two groups were formed: group 1 of 48 probands and 25 wives (the presence of hyperinsulinemia in the proband); group 2 of 44 probands and 32 their wives (controls with normal insulin levels). Anthropometric, arterial pressure and lipid-hormonal measurements were made by standard techniques. Nutrition was studied by random reproduction of 24-h diet.
  
  
  RESULTS
  More factors of risk to develop atherosclerosis and MS"X" components in probands and their wives were found in group 1. More frequent in the parents were the following MS components: hypoalphacholesterolemia, overweight, arterial hypertension, hyperapolipoprotein-B-emia. Vegetovascular asthenia in the probands' children predisposed to cardiovascular diseases is closely linked with the presence of hypoalphacholesterolemia, hypertriglyceridemia, overweight and arterial hypertension.
  
  
  CONCLUSIONS
  MS "X" for probands and their wives is a "malignant" risk factor for cardiovascular diseases; in the presence of IHD in father, vegetovascular asthenia in children is a risk factor of cardiovascular disease.
authors.forename: G I
authors.initials: GI
authors.lastname: Lifshits
authors.forename: K Iu
authors.initials: KIu
authors.lastname: Nikolaev
authors.forename: E A
authors.initials: EA
authors.lastname: Oteva
authors.forename: A A
authors.initials: AA
authors.lastname: Nikolaeva
mesh_terms: D000293:Adolescent; D000328:Adult; D001055:Apolipoproteins B / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology; D001342:Autonomic Nervous System Diseases / Q000097:blood / Q000150:complications; D001835:Body Weight; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000209:etiology; D006946:Hyperinsulinism / Q000097:blood / Q000150:complications* / Q000401:mortality; D006973:Hypertension / Q000097:blood / Q000209:etiology; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000209:etiology / Q000401:mortality; D017202:Myocardial Ischemia / Q000097:blood / Q000209:etiology* / Q000401:mortality; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D014280:Triglycerides; D014284:Triiodothyronine
vernacular_title: Ishemicheskaia bolezn' serdtsa i komponenty metabolicheskogo sindroma X.