title: [Unusual MR findings of Wernicke encephalopathy with cortical involvement].
abstract: We report a 48-year-old chronic alcoholic man, who developed consciousness disturbance, oculomotor paresis, and flaccid tetraplegia. His dietary habit was very poor since one month prior to the present admission and he was drinking alcoholic beverage. On admission on April 19, 1999, he showed disturbance of consciousness, tetraparesis without sensory disturbance, gaze paresis, and vertical nystagmus on downward gaze. His blood thiamine level was 12 ng/ml (normal range: 23.8-45.9). MRI demonstrated symmetric hyperintense lesions in the motor and premotor cortices bilaterally, in addition to other changes indicating Wernicke's encephalopathy. His motor weakness and oculomotor disturbance improved after treatment with intravenous thiamine. His cortical MRI also normalized. We believe that his cortical abnormality was responsible for his motor paresis and this is an unusual and unique finding for Wernicke's encephalopathy.
authors.affiliation: Department of Neurosurgery, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
authors.forename: Y
authors.initials: Y
authors.lastname: Inoue
authors.forename: E
authors.initials: E
authors.lastname: Tsuru
authors.forename: H
authors.initials: H
authors.lastname: Yasukouchi
authors.forename: A
authors.initials: A
authors.lastname: Yokota
mesh_terms: D000437:Alcoholism / Q000150:complications*; D002540:Cerebral Cortex / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology; D011782:Quadriplegia / Q000209:etiology; D013831:Thiamine / Q000097:blood; D014899:Wernicke Encephalopathy / Q000175:diagnosis*
chemical_list: D013831:Thiamine