title: A preliminary study on the anthelmintic activity of Calotropis procera latex against Haemonchus contortus infection in Najdi sheep.
abstract: The anthelmintic activity of Calotropis procera latex was investigated in sheep that had been infected with single oral doses of 12000 infective Haemonchus contortus larvae. Inappetence, dullness, erosive abomasitis, decreased haemoglobin concentration and increased eosinophils were the main features of haemonchosis in the sheep. In the sheep treated with single oral doses of 0.01 ml or 0.02 ml/kg body weight of C. procera latex, egg production was significantly reduced, but not completely suppressed, and fewer adult Haemonchus worms were found in the abomasum. Although the appetite improved, the haemoglobin concentration and serum copper, iron and zinc levels were still reduced after therapy with Calotropis latex. Calotropis latex showed a concentration-dependent larvicidal activity in vitro within 20 min of application.
authors.affiliation: Department of Veterinary Medicine, College of Agriculture and Veterinary Medicine, King Saud University, Saudi Arabia.
authors.forename: A A
authors.initials: AA
authors.lastname: Al-Qarawi
authors.forename: O M
authors.initials: OM
authors.lastname: Mahmoud
authors.lastname: Sobaih
authors.forename: E M
authors.initials: EM
authors.lastname: Haroun
authors.forename: S E
authors.initials: SE
authors.lastname: Adam
mesh_terms: D000018:Abomasum / Q000469:parasitology; D000818:Animals; D000871:Anthelmintics / Q000494:pharmacology* / Q000627:therapeutic use; D001798:Blood Proteins / Q000032:analysis; D003300:Copper / Q000097:blood; D005243:Feces / Q000469:parasitology; D006188:Haemonchiasis / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D006189:Haemonchus / Q000187:drug effects* / Q000254:growth & development; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000097:blood; D007814:Larva / Q000187:drug effects; D007840:Latex / Q000627:therapeutic use*; D010270:Parasite Egg Count / Q000662:veterinary; D010865:Pilot Projects; D010946:Plants, Medicinal; D012756:Sheep; D012757:Sheep Diseases / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D014508:Urea / Q000097:blood; D015032:Zinc / Q000097:blood
chemical_list: D000871:Anthelmintics; D001798:Blood Proteins; D006454:Hemoglobins; D007840:Latex; D003300:Copper; D014508:Urea; D007501:Iron; D015032:Zinc