title: Synthesis and preliminary pharmacological evaluation of coumestans with different patterns of oxygenation.
abstract: Five coumestans with different patterns of oxygenation in rings A and D were synthesized from resorcinol and aromatic aldehydes, and screened for their antimyotoxic activity. The most potent compound (2b, IC50 = 1 microM) was selected for study of its pharmacological profile.
authors.affiliation: Laboratório de Química Bioorgânica (LQB), Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, Brazil.
authors.lastname: da Silva AJM
authors.forename: P A
authors.initials: PA
authors.lastname: Melo
authors.forename: N M
authors.initials: NM
authors.lastname: Silva
authors.forename: F V
authors.initials: FV
authors.lastname: Brito
authors.forename: C D
authors.initials: CD
authors.lastname: Buarque
authors.forename: D V
authors.initials: DV
authors.lastname: de Souza
authors.forename: V P
authors.initials: VP
authors.lastname: Rodrigues
authors.forename: E S
authors.initials: ES
authors.lastname: Poças
authors.forename: F
authors.initials: F
authors.lastname: Noël
authors.forename: E X
authors.initials: EX
authors.lastname: Albuquerque
authors.forename: P R
authors.initials: PR
authors.lastname: Costa
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000378:metabolism; D017837:Bothrops; D020650:Combinatorial Chemistry Techniques; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology*; D003402:Creatine Kinase / Q000037:antagonists & inhibitors; D003435:Crotalid Venoms / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D005445:Flunitrazepam / Q000378:metabolism; D018757:GABA Modulators / Q000378:metabolism; D020128:Inhibitory Concentration 50; D010100:Oxygen / Q000737:chemistry; D010936:Plant Extracts / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000378:metabolism
chemical_list: D014151:Anti-Anxiety Agents; D003374:Coumarins; D003435:Crotalid Venoms; D004791:Enzyme Inhibitors; D018757:GABA Modulators; D010936:Plant Extracts; C051122:wedelolactone; D005445:Flunitrazepam; D003402:Creatine Kinase; D000254:Sodium-Potassium-Exchanging ATPase; D010100:Oxygen