[Interrelationship between disease activity and nutrient intake or serum cytokine in patients with rheumatoid arthritis].
OBJECTIVE
This study was designed to investigate the possibility of nutrition guidance for patients with rheumatoid arthritis (RA). We studied interrelationship between disease activity and nutrient intake or serum cytokine concentration in patients with RA.


METHODS
Dietary survey was performed to assess nutrient intake of RA patients. Disease activity parameters, such as weariness index, arthritically index and QOL index were evaluated by self-questionnaire. CRP and serum cytokine concentrations were measured. Interactions between these parameters and nutrient intake were analyzed.


RESULTS
In comparison of nutrient intake between patients with RA and healthy controls, RA patients indicated lower ratio of polyunsaturated to saturated fatty acid (P/S) than controls. Preceding with the analysis between disease activity parameter and nutrient intake, RA patients were divided into two groups according to their activities. High weariness group indicated higher lipid intake and energy supplies from fat than low group, suggesting the relationship between disease activity and lipid intake in RA patients. From the comparative study of serum cytokine concentration between patients with RA and healthy controls, RA patients indicated higher concentration of IL-1 beta, IL-6 and IL-8. Serum concentrations of these proinflammatory cytokines correlated significantly with some nutrient intakes.


CONCLUSIONS
These results imply the relationship between nutrient intake and disease activity in patients with RA. It is important to develop nutrition guidance to improve symptoms for patients with RA.
Hirasawa
R
R
Division Clinical Nutrition, Department of Food and Nutrition, Japan Women's University, Bunkyo-ku, Tokyo.
Kato
C
C
Utsuyama
M
M
Hirokawa
K
K
Sato
K
K
D001172:Arthritis, Rheumatoid / Q000175:diagnosis / Q000503:physiopathology*; D015415:Biomarkers / Q000097:blood; D016207:Cytokines / Q000097:blood*; D004041:Dietary Fats / Q000009:adverse effects; D004734:Energy Metabolism; D005221:Fatigue; D005260:Female; D006801:Humans; D008875:Middle Aged; D009747:Nutritional Physiological Phenomena; D009752:Nutritional Status; D011788:Quality of Life
D015415:Biomarkers; D016207:Cytokines; D004041:Dietary Fats