title: Electron transfer vs. proton transfer within radical-cation clusters of guanosine and deoxyguanosine with substituted naphthalenes and sinapinic acid.
abstract: Guanosine (G) and deoxyguanosine (dG) radical cations can be generated in the gas phase by single electron transfer (SET) within nucleoside-dimethoxynaphthalenes (1-2) electron-bound heterodimers produced by fast atom bombardment in a four sector mass spectrometer. The nucleobase guanine is much more easily oxidized when it is linked to a ribose moiety. The radical cation dimers formed by G and dG with sinapinic acid behave as proton-bound heterodimers. The experiments mimic to some extent the migration of radical sites within stacking bases which causes DNA damaging through depurination processes.
authors.affiliation: Dipartimento di Chimica, Università della Calabria, Arcavacata di Rende, CS, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Liguori
authors.forename: A
authors.initials: A
authors.lastname: Napoli
authors.forename: G
authors.initials: G
authors.lastname: Sindona
mesh_terms: D002412:Cations; D003373:Coumaric Acids / Q000737:chemistry* / Q000528:radiation effects; D003849:Deoxyguanosine / Q000737:chemistry*; D004579:Electron Transport; D006151:Guanosine / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D009281:Naphthalenes / Q000737:chemistry* / Q000528:radiation effects; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014466:Ultraviolet Rays
chemical_list: D002412:Cations; D003373:Coumaric Acids; D009281:Naphthalenes; D006151:Guanosine; C073734:sinapinic acid; D006859:Hydrogen; D003849:Deoxyguanosine