[Morpho-functional condition of heart in patients with lymphogranulomatosis late after chemoradiotherapy].
OBJECTIVE
The study of clinical and echocardiographic status of the heart in patients with lymphogranulomatosis (LGM) late after chemoradiotherapy.


METHODS
44 patients with IIA-IV stage of LGM exposed to irradiation of lymph nodes and polychemotherapy according to the schemes ACOP, ABVD, COPP, CHOP, CVPP were examined. Echocardiography was carried out on the unit Sigma-44 and Toshiba.


RESULTS
Some changes in the heart by type of myocardiodystrophy or endomyocardial fibrosis were found. The latter are characterized by diminution of the left and (or) right ventricles due to apex obliteration, hardening and thickening of the endocardium and subvalvular structures, diastolic dysfunction and pulmonary hypertension. The main and additional signs are distinguished. The reasons of endomyocardial fibrosis are discussed: severity of the disease, frequent exacerbations and, consequently, higher doses of specific chemoradiotherapy.


CONCLUSIONS
It is necessary to employ sparing policy in planning radiotherapy after high loading antracycline antibiotics.
Loseva
M P
MP
Purtova
L A
LA
Gavalova
R F
RF
Pospelova
T I
TI
Soldatova
G S
GS
D000293:Adolescent; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D015150:Echocardiography, Doppler; D005260:Female; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000187:drug effects / Q000503:physiopathology* / Q000528:radiation effects; D006689:Hodgkin Disease / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000503:physiopathology* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D018714:Radiotherapy, Adjuvant; D013997:Time Factors; D016276:Ventricular Function / Q000187:drug effects / Q000528:radiation effects; D020257:Ventricular Remodeling / Q000187:drug effects / Q000528:radiation effects
D000970:Antineoplastic Agents
Morfofunktsional'noe sostoianie serdtsa pri limfogranulematoze v otdalennye sroki posle khimioluchevoĭ terapii.