A possible pathogenic role of CD8+ T cells and their derived cytokine, IL-16, in SLE.
Current investigations into the role of CD8+ T cells and their derived cytokine, interleukin (IL)-16, in the induction of CD4+ T cell abnormalities in systemic lupus erythematosus (SLE) were reviewed and discussed on the basis of results mainly obtained in our laboratory.
Sekigawa
I
I
Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka, Japan.
Matsushita
M
M
Lee
S
S
Maeda
N
N
Ogasawara
H
H
Kaneko
H
H
Iida
N
N
Hashimoto
H
H
D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D006801:Humans; D019410:Interleukin-16 / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology
D019410:Interleukin-16