title: [Ginkgo special extract EGb 761 in tinnitus therapy. An overview of results of completed clinical trials].
abstract: In a systematic search of the literature 19 clinical trials investigating the effects of tinnitus treatment with Ginkgo biloba special extract EGb 761 were identified and evaluated. The results of eight controlled studies on tinnitus due to cerebrovascular insufficiency or labyrinthine disorders of varying genesis for the most part show a statistically significant superiority of treatment with the Ginkgo biloba special extract EGb 761 as compared with placebo or reference drugs applied of periods of one to three months. Open studies, too, some involving large numbers of patients, revealed appreciable improvements under ginkgo treatment. Therapeutic success was not directly correlated with either the genesis or the duration of tinnitus. However, investigations of prognostic factors revealed that short-standing disorders have a better prognosis, so that better results can be expected from early-onset treatment. The tolerability of Ginkgo biloba special extract EGb 761 was excellent, and in this respect the controlled clinical trials revealed little difference between drug-treated and control groups.
authors.affiliation: Facharzt für Hals-Nasen-Ohrenheilkunde, Allergologie, Chirotherapie, Stimm- und Sprachstörungen, Neuensteinstrasse 14, D-76227 Karlsruhe.
authors.forename: N
authors.initials: N
authors.lastname: Holstein
mesh_terms: D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000009:adverse effects / Q000627:therapeutic use*; D020441:Ginkgo biloba; D006801:Humans; D018696:Neuroprotective Agents / Q000009:adverse effects / Q000627:therapeutic use*; D010936:Plant Extracts; D016032:Randomized Controlled Trials as Topic; D014012:Tinnitus / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome; D000096983:Ginkgo Extract
chemical_list: D005419:Flavonoids; D018696:Neuroprotective Agents; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract
vernacular_title: Ginkgo-Spezialextrakt EGb 761 in der Tinnitus-Therapie. Eine Ubersicht über die Ergebnisse der durchgeführten klinischen Prüfungen.