title: [Accumulation of Ca ions in intracellular structures of rat myometrium during subacute, acute, and chronic administration of ethanol].
abstract: The effects of subacute, acute and chronic ethanol exposure on the activity of Ca(2+)-accumulating systems of mitochondria and endoplasmic reticulum in myometrial cells of nonpregnant estrogen-treated rats were studied. It has been shown that the activity of Ca(2+)-accumulating system of mitochondria was higher than the activity of Ca(2+)-accumulating system of endoplasmic reticulum in myometrial cells from control, acute and subacute treated with ethanol rats. Under ethanol chronical assumption both Ca(2+)-accumulation in mitochondria and Ca(2+)-transporting activity of endoplasmic reticulum are inhibited. In the latter ease Mg2+, ATP-dependent Ca(2+)-pump lost its sensitivity to oxytocin.
authors.affiliation: A. V. Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
authors.forename: L A
authors.initials: LA
authors.lastname: Borisova
authors.forename: L G
authors.initials: LG
authors.lastname: Babich
authors.forename: S G
authors.initials: SG
authors.lastname: Shlykov
authors.forename: S  A
authors.initials: S
authors.lastname: Kosterin
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D008928:Mitochondria / Q000378:metabolism; D009215:Myometrium / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
chemical_list: D000431:Ethanol; D002118:Calcium
vernacular_title: Akkumuliatsiia ionov Ca vo vnutrikletochnykh strukturakh mimetriia krys pri podostrom, ostrom i khronichskom vvedenii étanola.