Inadvertent diclofenac rechallenge from generic and non-generic prescribing, leading to liver transplantation for fulminant liver failure.
This case report describes fulminant hepatic failure in a 53-year-old female caused by inadvertent rechallenging with diclofenac, treated by orthotopic liver transplantation. The case also illustrates the hazards of using both generic and non-generic drug prescribing, with drugs that are known to be toxic. The literature on non-steroidal anti-inflammatory drugs and hepatoxicity is reviewed.
Greaves
R R
RR
Department of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK.
Agarwal
A
A
Patch
D
D
Davies
S E
SE
Sherman
D
D
Reynolds
N
N
Rolles
K
K
Davidson
B R
BR
Burroughs
A K
AK
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects*; D016568:Drugs, Generic; D005260:Female; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced* / Q000601:surgery*; D016031:Liver Transplantation; D008875:Middle Aged
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016568:Drugs, Generic; D004008:Diclofenac