Quinolactacins A, B and C: novel quinolone compounds from Penicillium sp. EPF-6. II. Physico-chemical properties and structure elucidation.
Three novel quinolone compounds, quinolactacins A (1), B (2) and C (3), have been found from the fermentation broth of Penicillium sp. EPF-6, a fungus isolated from the larvae of mulberry pyralid (Margaronia pyloalis Welker). The molecular formulas of 1, 2 and 3 were determined to be C16H18N2O2, C15H16N2O2 and C16H18N2O3, respectively by FAB-MS and NMR spectral analyses. The structures of these compounds have a novel quinolone skeleton with a gamma-lactam ring consisting of C12H8N2O2 as the common chromophore.
Takahashi
S
S
Department of Biosciences, Teikyo University, Utsunomiya, Japan.
Kakinuma
N
N
Iwai
H
H
Yanagisawa
T
T
Nagai
K
K
Suzuki
K
K
Tokunaga
T
T
Nakagawa
A
A
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000900:Anti-Bacterial Agents; D015363:Quinolones; C420723:quinolactacin A; C420724:quinolactacin B; C420725:quinolactacin C