title: Heat-shock protein (HSP70-2) allelic frequencies in three distinct Mexican populations.
abstract: The major histocompatibility complex (MHC) genes are highly polymorphic and therefore have been useful in population genetics and disease association studies. We analyzed restriction fragment length polymorphism of HSP70-2 alleles in healthy unrelated Mestizo, Mazatecan and Nahua populations. Both Indian groups, Mazatecans and Nahuas, were in Hardy-Weinberg equilibrium, while Mestizos were in disequilibrium (chi 2 = 0.399; P < 0.05). The Mazatecan Indians presented a high frequency of BB homozygosity (17.35%) compared to Mestizos (5%) (P = 0.01). Mexican ethnic groups present differences in distribution of BB genotype. The low frequency of BB genotype in Mestizos may be the result of a negative selection process.
authors.affiliation: Department of Immunology and Rheumatology, Instituto Nacional de la Nutrición Salvador Zubirán, Vasco de Quiroga 15 Tlalpan 14000, México D.F., Mexico.
authors.forename: J
authors.initials: J
authors.lastname: Zúñiga
authors.forename: G
authors.initials: G
authors.lastname: Vargas-Alarcón
authors.forename: N
authors.initials: N
authors.lastname: Osnaya
authors.forename: S
authors.initials: S
authors.lastname: Martínez-Tripp
authors.forename: T S
authors.initials: TS
authors.lastname: Rodríguez-Reyna
authors.forename: B
authors.initials: B
authors.lastname: Hernández-Martinez
authors.forename: R
authors.initials: R
authors.lastname: Hesiquio
authors.forename: G
authors.initials: G
authors.lastname: Hernández-Pacheco
authors.forename: R
authors.initials: R
authors.lastname: Gamboa
authors.forename: F
authors.initials: F
authors.lastname: Juárez
authors.forename: N
authors.initials: N
authors.lastname: Salgado
authors.forename: J
authors.initials: J
authors.lastname: Granados
mesh_terms: D000483:Alleles; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D008800:Mexico; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D018840:HSP70 Heat-Shock Proteins