title: Synthesis of N-[4-(propyl)cyclohexyl]-amides with anti-inflammatory and analgesic activities.
abstract: Seventeen (un)substituted N-[4-(propyl)cyclohexyl]-amides (6a-h, 7a-h and 8) were synthesized and tested as anti-inflammatory and analgesic agents. The substituents on the aromatic ring were chosen in order to study the influence of electron-withdrawing or electron-donating residues, that change the electronic density on the aromatic moiety. The pharmacological results allow drawing some preliminary considerations on structure-activity relationships.
authors.affiliation: Dipartimento Farmaco Chimico Tossicologico, Facoltà di Farmacia, Università di Sassari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Pau
authors.forename: G
authors.initials: G
authors.lastname: Boatto
authors.forename: B
authors.initials: B
authors.lastname: Asproni
authors.forename: M
authors.initials: M
authors.lastname: Palomba
authors.forename: L
authors.initials: L
authors.lastname: Auzzas
authors.forename: R
authors.initials: R
authors.lastname: Cerri
authors.forename: F
authors.initials: F
authors.lastname: Palagiano
authors.forename: W
authors.initials: W
authors.lastname: Filippelli
authors.forename: G
authors.initials: G
authors.lastname: Falcone
authors.forename: G
authors.initials: G
authors.lastname: Motola
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology; D002351:Carrageenan; D003510:Cyclohexanes / Q000138:chemical synthesis / Q000494:pharmacology; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D011247:Pregnancy; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013276:Stomach Ulcer / Q000139:chemically induced; D013329:Structure-Activity Relationship
chemical_list: D000577:Amides; D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003510:Cyclohexanes; D002351:Carrageenan