title: On the biogenesis of the myelin sheath: cognate polarized trafficking pathways in oligodendrocytes.
abstract: Oligodendrocytes, the myelinating cells of the central nervous system, are capable of transporting vast quantities of proteins and of lipids, in particular galactosphingolipids, to the myelin sheath. The sheath is continuous with the plasma membrane of the oligodendrocyte, but the composition of both membrane domains differs substantially. Given its high glycosphingolipid and cholesterol content the myelin sheath bears similarity to the lipid composition of the apical domain of a polarized cell. The question thus arises whether myelin components, like typical apical membrane proteins are transported by an apical-like trafficking mechanism to the sheath, involving a 'raft'-mediated mechanism. Indeed, the evidence indicates the presence of cognate apical and basolateral pathways in oligodendrocytes. However, all major myelin proteins do not participate in this pathway, and remarkably apical-like trafficking seems to be restricted to the oligodendrocyte cell body. In this review, we summarize the evidence on the existence of different trafficking pathways in the oligodendrocyte, and discuss possible mechanisms separating the oligodendrocyte's membrane domains.
authors.affiliation: Department of Membrane Cell Biology, Faculty of Medical Sciences, University of Groningen, The Netherlands.
authors.forename: H
authors.initials: H
authors.lastname: de Vries
authors.forename: D
authors.initials: D
authors.lastname: Hoekstra
mesh_terms: D000818:Animals; D001692:Biological Transport; D002454:Cell Differentiation; D005699:Galactosylceramides / Q000378:metabolism*; D006801:Humans; D007365:Intercellular Junctions / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism*; D009836:Oligodendroglia / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D013107:Sphingolipids / Q000737:chemistry / Q000378:metabolism
chemical_list: D005699:Galactosylceramides; D011506:Proteins; D013107:Sphingolipids