title: Cytotoxic labdane diterpenoids from Croton oblongifolius.
abstract: Three labdane diterpenoids, 2-acetoxy-3-hydroxy-labda-8(17),12(E)-14-triene, 3-acetoxy-2-hydroxy-labda-8(17),12(E)-14-triene, and 2,3-dihydroxy-labda-8(17),12(E),14-triene were isolated from stem bark of Croton oblongifolius. Their structures were established by spectroscopic data, and each was also tested for cytotoxicity against various human tumor cell lines. The latter compound showed non-specific, moderate, cytotoxicities against all the cell lines; whereas the first two compounds were less active.
authors.affiliation: Department of Chemistry, Faculty of Science, Chulalongkorn University, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Roengsumran
authors.forename: A
authors.initials: A
authors.lastname: Petsom
authors.forename: N
authors.initials: N
authors.lastname: Kuptiyanuwat
authors.forename: T
authors.initials: T
authors.lastname: Vilaivan
authors.forename: N
authors.initials: N
authors.lastname: Ngamrojnavanich
authors.forename: C
authors.initials: C
authors.lastname: Chaichantipyuth
authors.forename: S
authors.initials: S
authors.lastname: Phuthong
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009284:Naphthols / Q000737:chemistry*; D019685:Rosales / Q000737:chemistry*; D013057:Spectrum Analysis; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D009284:Naphthols; C089207:ent-8-hydroxylabda-13(16),14-diene