Transient receptor potential protein mRNA expression in rat substantia nigra.
Receptor gated Ca2+ entry has been associated with transient receptor potential (TRP) proteins encoded by several different genes. Here, we compare expression of mRNA for TRP isoforms encoded by genes TRP1-6 in the rat substantia nigra and whole brain. The substantia nigra and the whole brain expressed mRNA predominantly for TRP3 and TRP6. The levels of TRP1, 2, 4 and 5 were very low in both. The TRP6 mRNA levels in substantia nigra and the whole brain were comparable while those for TRP3 were significantly lower in substantia nigra than in the whole brain. Thus substantia nigra differs from the whole brain in its TRP expression.
Sylvester
J B
JB
Department of Biology, McMaster University, Hamilton, Ontario, Canada.
Mwanjewe
J
J
Grover
A K
AK
D000818:Animals; D015220:Calcium Channels / Q000235:genetics*; D020013:Calcium Signaling / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology*; D008297:Male; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013378:Substantia Nigra / Q000166:cytology / Q000378:metabolism*; D050052:TRPC Cation Channels
D015220:Calcium Channels; D012333:RNA, Messenger; D050052:TRPC Cation Channels; C104603:TRPC3 cation channel