[Morphodensitometric evaluation of lymphocytes enzymatic status in pathogenesis of chronic alcoholism].
Activities of succinate dehydrogenase (SDH), alpha-glycerophosphate dehydrogenase (alpha-GPDH), and nonspecific esterase (NE) were studied in blood lymphocytes of healthy men and chronic alcoholics. SDH activity was notably decreased, while the levels of alpha-GPDH and NE were increased in alcoholics. The detected metabolic changes suggest lymphocyte dysfunction and hence, impairment of neuroimmune relationships, which may be the central component in the pathogenesis of chronic alcoholism.
Al'brant
A I
AI
Kadricheva
S G
SG
Savchenko
A A
AA
Smolina
E V
EV
D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000201:enzymology / Q000276:immunology*; D015415:Biomarkers; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000276:immunology*; D002908:Chronic Disease; D005993:Glycerolphosphate Dehydrogenase / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000201:enzymology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013385:Succinate Dehydrogenase / Q000276:immunology*
D015415:Biomarkers; D005993:Glycerolphosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase
Morfodensitometricheskaia otsenka fermentativnogo statusa limfotsitov pri issledovanii patogeneza khronicheskogo alkogolizma.