General synthesis of alpha-substituted 3-bisaryloxy propionic acid derivatives as specific MMP inhibitors.
Modulations of alpha and aryl substitutions on 3-aryloxy propionic acid hydroxamates led to novel and potent inhibitors of MMP-2,3,9 and 13, and selectivity versus MMP-1.
Chollet
A M
AM
Institut de Recherches Servier, Croissy sur Seine, France.
Le Diguarher
T
T
Murray
L
L
Bertrand
M
M
Tucker
G C
GC
Sabatini
M
M
Pierré
A
A
Atassi
G
G
Bonnet
J
J
Casara
P
P
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D018501:Antirheumatic Agents / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology; D001682:Biological Availability; D002356:Cartilage / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D004355:Drug Stability; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D051379:Mice; D008862:Microsomes, Liver; D009362:Neoplasm Metastasis / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011422:Propionates / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000494:pharmacology*; D011509:Proteoglycans / Q000187:drug effects / Q000378:metabolism; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D018501:Antirheumatic Agents; D061965:Matrix Metalloproteinase Inhibitors; D011422:Propionates; D011509:Proteoglycans