[Protective efficacy of combined administration of the multicomponent vaccine and the immunomodulator myelopid in experimental infections in mice].
The influence of myelopid (MP) on the protective activity of polycomponent vaccine VP-4 prepared from the antigens of opportunistic bacteria was studied on experimental infections of mice, caused by Klebsiella pneumoniae, Salmonella typhimurium and Staphylococcus aureus. In staphylococcal and Klebsiella infections the joint administration of vaccine VP-4 and MP produced more pronounced protective effect than each of these preparations, introduced alone. The protective action of vaccine VP-4 was specially enforced by MP in cases of local staphylococcal infection. Recommendations on the joint use of two or more immunomodulating agents are possible only on the basis of the experimental substantiation of their effect in definite infections.
Stepanenko
R N
RN
Research Institute of Immunology, Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
Egorova
N B
NB
Kurbatova
E A
EA
Efremova
V N
VN
Kuz'mina
L A
LA
Skoptsova
S V
SV
Novikova
E M
EM
Kondarshova
M M
MM
Gruber
I M
IM
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D001424:Bacterial Infections / Q000517:prevention & control*; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D023421:Models, Animal; D009842:Oligopeptides / Q000008:administration & dosage*; D017778:Vaccines, Combined / Q000008:administration & dosage
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines; D009842:Oligopeptides; C088865:VP-4 vaccine; D017778:Vaccines, Combined; C048617:myelopeptides
Protektivnaia éffektivnost' sovmestnogo primeneniia polikomponentnoĭ vaktsiny i immunomoduliatora mielopida na model'nykh infektsiiakh mysheĭ.