title: Herpes simplex virus type 1 (HSV-1)--induced retinitis following herpes simplex encephalitis: indications for brain-to-eye transmission of HSV-1.
abstract: Herpes simplex encephalitis is a severe neurological disease with high mortality and morbidity rates. Reactivated herpes simplex virus type 1 (HSV-1) can cause relapses and might even spread to the retina, where it can induce a potentially blinding eye disease, known as acute retinal necrosis. In the present study, the HSV-1 strains in the brain and eye of 2 patients with acute retinal necrosis following an episode of herpes simplex encephalitis were genotyped. The HSV-1 strains in both the brain and eye were identical in each patient, but they differed interindividually. The data suggest brain-to-eye transmission of HSV-1 in these patients.
authors.affiliation: Department of Virology, Erasmus University, Rotterdam, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Maertzdorf
authors.forename: A
authors.initials: A
authors.lastname: Van der Lelij
authors.forename: G S
authors.initials: GS
authors.lastname: Baarsma
authors.forename: A D
authors.initials: AD
authors.lastname: Osterhaus
authors.forename: G M
authors.initials: GM
authors.lastname: Verjans
mesh_terms: D000368:Aged; D001483:Base Sequence; D004279:DNA, Viral / Q000235:genetics; D020803:Encephalitis, Herpes Simplex / Q000235:genetics* / Q000635:transmission*; D005260:Female; D018259:Herpesvirus 1, Human / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D012173:Retinitis / Q000235:genetics*
chemical_list: D004279:DNA, Viral