Inhibition of the neuronal insulin receptor. An in vivo model for sporadic Alzheimer disease?
It has been hypothesized that a central even in the early pathogenesis of sporadic Alzheimer disease (SAD) is the dysfunction of the neuronal insulin receptor signal transduction. To prove this, this receptor was inhibited by a triplicate icv application of STZ. Insulin binding sites were upregulated as in SAD. With respect to glucose transport proteins, detailed investigations are necessary.
Hoyer
S
S
Department of Pathochemistry & General Neurochemistry, University of Heidelberg, Im Neuenheimer Feld 220/221, D-69120 Heidelberg, Germany. siegfried_hoyer@med.uni-heidelberg.de
Lee
S K
SK
Löffler
T
T
Schliebs
R
R
D018528:ATP-Binding Cassette Transporters; D000544:Alzheimer Disease / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology; D004195:Disease Models, Animal; D005905:Glyburide / Q000378:metabolism; D007276:Injections, Intraventricular; D007328:Insulin / Q000378:metabolism*; D007457:Iodine Radioisotopes; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D024661:Potassium Channels, Inwardly Rectifying; D051381:Rats; D011972:Receptor, Insulin / Q000037:antagonists & inhibitors*; D011955:Receptors, Drug / Q000187:drug effects / Q000378:metabolism; D013311:Streptozocin / Q000008:administration & dosage / Q000494:pharmacology*; D064233:Sulfonylurea Receptors
D018528:ATP-Binding Cassette Transporters; D007328:Insulin; D007457:Iodine Radioisotopes; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying; D011955:Receptors, Drug; D064233:Sulfonylurea Receptors; D013311:Streptozocin; D011972:Receptor, Insulin; D005905:Glyburide