Polysaccharides extracted from human tubercle bacilli (specific substance of Maruyama) reduces carcinogenesis in murine ulcerative colitis.
Polysaccharides extracted from human tubercle bacilli (specific substance of Maruyama) have been clinically applied in patients with malignant diseases in Japan and other countries. It is known that increased colorectal carcinogenesis occurs in patients with ulcerative colitis. The repeated mucosal necrosis-regeneration sequence in chronic ulcerative colitis induced with 3 % dextran sulfate sodium led to colorectal carcinogenesis in azoxymethane-pretreated mice. Simultaneously multiple injections with the polysaccharides reduced the increases in thymidylate synthase and thymidine kinase activities and a number of bromodeoxyuridine-incorporated S-phase cells in colorectal tissues resulted in the reduction of tumorous regions with high-grade dysplasia.
Sakamoto
S
S
Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113-8510, Japan. motoend@mri.tmd.ac.jp
Okayasu
I
I
Iida
K
K
Fujita
K
K
Yarimizu
T
T
Nagasawa
H
H
D000818:Animals; D001397:Azoxymethane; D001407:Bacillus / Q000737:chemistry; D001835:Body Weight / Q000187:drug effects; D001973:Bromodeoxyuridine / Q000378:metabolism; D002273:Carcinogens; D003093:Colitis, Ulcerative / Q000139:chemically induced / Q000201:enzymology; D003106:Colon / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000201:enzymology / Q000517:prevention & control*; D016264:Dextran Sulfate; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D012007:Rectum / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D016196:S Phase / Q000187:drug effects; D013047:Specific Pathogen-Free Organisms; D013937:Thymidine Kinase / Q000378:metabolism; D013940:Thymidylate Synthase / Q000378:metabolism
D002273:Carcinogens; D011135:Polysaccharides, Bacterial; D016264:Dextran Sulfate; D013940:Thymidylate Synthase; D013937:Thymidine Kinase; D001973:Bromodeoxyuridine; D001397:Azoxymethane