title: Urine drug screens in overdose patients do not contribute to immediate clinical management.
abstract: A prospective study assessed whether routine urine drug screens might alter the management of overdose patients. Urine was collected from 107 patients with a diagnosis of deliberate self-poisoning seen in the emergency department (ED) of a teaching hospital. The mean age of patients was 36 years (range 13-86 years) and 64% were female. All patients recovered after standard investigations and management, which did not include knowledge of urinary drug screen results. Two hundred ninety-seven compounds were detected in the 107 urine samples. Twenty percent were drugs administered in the ED. Sixty-five percent of patients were found to have taken more than one drug. Benzodiazepines were detected in 18% of samples, paracetamol in 10%, and alcohol in 8%. Sixty-one drugs, in 35 people, were identified that the patients did not report taking. Of these, paracetamol (10), benzodiazepines (9), and tetrahydrocannabinol (8) were the most common. All patients in whom paracetamol was found had already had paracetamol detected in blood and appropriate management instituted. If the results of urine screening had been immediately available this would not have affected the management or outcome of any patient.
authors.affiliation: Department of Clinical Pharmacology, Royal North Shore Hospital, St. Leonards, NSW, Australia.
authors.forename: R E
authors.initials: RE
authors.lastname: Montague
authors.forename: R F
authors.initials: RF
authors.lastname: Grace
authors.forename: J H
authors.initials: JH
authors.lastname: Lewis
authors.forename: G M
authors.initials: GM
authors.lastname: Shenfield
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D062787:Drug Overdose / Q000628:therapy* / Q000652:urine*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D016896:Treatment Outcome; D016482:Urinalysis