title: 3D-reconstruction of craniofacial structures of a human anencephalic fetus. Case report.
abstract: It was the purpose of this study to investigate the craniofacial bones, cartilages and major blood vessels of a human anencephalic fetus and to describe the malformations of these structures accompanying this developmental disruption. The head of a 16 week old human fetus with anencephaly was serially sectioned and the craniofacial bones, cartilages and major blood vessels were traced and reconstructed by 3D-computer technology. The sphenoidal, temporal and occipital bones showed severe malformations, whereas the bones of the facial cranium were normally developed. Both internal carotid arteries ended within the cerebro-vascular area with no further branches. The vertebral arteries also ended within the cerebro-vascular area. No arterial circle of Willis was developed. The notochord terminated normally in the sphenoid body. The observations indicate that the possible reason for this malformation was non-closure of the anterior neuropore of the neural tube. The normal termination of the notochord suggests that it had no influence on the pathogenesis of this malformation. The malformations of the temporal and occipital bones are contradictory to the hypothesis of Marin-Padilla (1991) that anencephaly is caused by a maldevelopment of the sphenoidal bone.
authors.affiliation: Department of Anatomy, Faculty of Dental Medicine, University of Witten/Herdecke, Germany. wolfa@uni-wh.de
authors.forename: W H
authors.initials: WH
authors.lastname: Arnold
authors.forename: M
authors.initials: M
authors.lastname: Lang
authors.forename: G H
authors.initials: GH
authors.lastname: Sperber
mesh_terms: D000028:Abortion, Induced; D000757:Anencephaly / Q000196:embryology / Q000473:pathology*; D005147:Facial Bones / Q000196:embryology* / Q000473:pathology; D005260:Female; D005333:Fetus; D005865:Gestational Age; D006801:Humans; D007091:Image Processing, Computer-Assisted; D010902:Pituitary Gland / Q000196:embryology / Q000473:pathology; D011247:Pregnancy; D012886:Skull / Q000196:embryology* / Q000473:pathology