Thymic humoral factor-gamma 2 augments immune cell response and exerts antitumor activity in murine model systems.
The immunomodulatory and antimetastatic/antitumor activity of thymic humoral factor-gamma 2 (THF-gamma 2) was evaluated in BALB/c-mice. Daily subcutaneous applications (7 consecutive days, 20, 200 ng of THF-gamma 2 per injection/mouse) upregulated counts of thymocytes and peripheral blood cells in tumor bearing mice. To check the influence of THF-gamma 2 treatment on the growth of experimental metastases, RAW 117 H10 lymphosarcoma cells or L-1 sarcoma cells were intravenously inoculated into BALB/c-mice to establish liver or lung metastases, respectively. Local tumor growth was induced by subcutaneous injection of L-1 sarcoma cells. THF-gamma 2 was subcutaneously administered daily for 7 consecutive days starting 24 hrs after tumor cell challenge. Organ colonization as well as local tumor growth were investigated on day 14 after tumor cell inoculation and demonstrated a statistically significant (p < 0.05) reduction of experimental liver and lung metastases and local tumor growth for THF-gamma 2 treated mice.
Beuth
J
J
Institute for Scientific Evaluation of Naturopathy, University of Cologne, Robert-Koch-Str. 10, 50931 Cologne, Germany.
Schierholz
J M
JM
Mayer
G
G
Keisari
Y
Y
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D004354:Drug Screening Assays, Antitumor; D007111:Immunity, Cellular / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D008113:Liver Neoplasms / Q000517:prevention & control / Q000556:secondary*; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary*; D008228:Lymphoma, Non-Hodgkin / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D009842:Oligopeptides / Q000627:therapeutic use*; D012509:Sarcoma / Q000517:prevention & control / Q000556:secondary; D013601:T-Lymphocytes / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D000276:Adjuvants, Immunologic; D016588:Anticarcinogenic Agents; D009842:Oligopeptides; C064563:thymic humoral factor gamma 2