Effect of niclosamide on the marketable fish Liza ramada (Risso, 1826) concerning accumulation in muscles and activities of three metabolic liver enzymes.
The accumulation in muscles and the effect of different concentrations of niclosamide (Bayluscide) on the metabolic enzymes; succinate dehydrogenase (SDH), pyruvate dehydrogenase (PDH) and lactate dehydrogenase (LDH) in the liver of the Thin-lip grey mullet after 1, 2 & 3 weeks were studied. The molluscicide residues were detected in the muscles. The residues increased with the increase of concentrations of niclosamide as well as the time of exposure. On the other hand, LDH showed significant increase. But, SDH and PDH showed significant decrease. No doubt, this disturbance in the three liver enzymes cause disturbance in the process of metabolism. The important point is what about man who consumes a fish with niclosamide accumulated in its muscles.
Zinada
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Department of Biology, Faculty of Science, King Abdel Aziz University, Jeddah, Saudi Arabia.
D000818:Animals; D005399:Fishes / Q000378:metabolism*; D005506:Food Contamination; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008975:Molluscacides / Q000009:adverse effects / Q000493:pharmacokinetics*; D009132:Muscles / Q000378:metabolism*; D009534:Niclosamide / Q000009:adverse effects / Q000493:pharmacokinetics*; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
D008975:Molluscacides; D011768:Pyruvate Dehydrogenase Complex; D009534:Niclosamide; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase