title: [Stereotactic irradiation of liver metastases].
abstract: OBJECTIVE
  A number of minimal-invasive methods have been developed for the treatment of non-resectable liver metastases. A focused high dose can be delivered to a liver tumor with sparing of surrounding normal liver tissue using non-invasive stereotactic techniques.
  
  
  METHODS
  Sixty-six metastases were treated stereotactically in 43 patients during a phase 2 trial.
  
  
  RESULTS
  There were no major side effects observed. The actuarial local control was 82% after 18 months. The median actuarial survival was 24 months. However, there was a significantly improved survival in patients without additional extrahepatic tumor manifestation at the time of treatment compared to those, who were treated in palliative intention (87% vs. 24% after 18 months, p = 0.001 (log-rank).
  
  
  CONCLUSIONS
  Stereotactic single dose irradiation is a non-invasive and safe treatment option for patients with inoperable liver metastases. Phase III studies will further evaluate this new approach.
authors.affiliation: Klinische Kooperationseinheit Strahlentherapeutische Onkologie, Deutsches Krebsforschungszentrum, Abt. E0500, Im Neuenheimer Feld 280, 69120 Heidelberg. klaus@herfarth.de
authors.forename: K K
authors.initials: KK
authors.lastname: Herfarth
authors.forename: J
authors.initials: J
authors.lastname: Debus
authors.forename: F
authors.initials: F
authors.lastname: Lohr
authors.forename: M L
authors.initials: ML
authors.lastname: Bahner
authors.forename: M
authors.initials: M
authors.lastname: Wannenmacher
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy; D015179:Colorectal Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000401:mortality / Q000532:radiotherapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011880:Radiotherapy Planning, Computer-Assisted; D015996:Survival Rate; D014057:Tomography, X-Ray Computed
vernacular_title: Stereotaktische Bestrahlung von Lebermetastasen.