title: Analgesic components of saposhnikovia root (Saposhnikovia divaricata).
abstract: By activity-oriented separation using the writhing method in mice, the analgesic components of Saposhnikovia root (Saposhnikovia divaricata Schischkin; Umbelliferae) were identified to be chromones, coumarins, polyacetylenes and 1-acylglycerols. Two new components, divaricatol and (3'S)-hydroxydeltoin, were also isolated. The most potent analgesia was observed in chromones such as divaricatol, ledebouriellol and hamaudol, which inhibited writhing inhibition at an oral dose of 1 mg/kg in mice. Acylglycerols also showed inhibition significantly at a dose of 5 mg/kg. In some pharmacological tests using sec-O-glucosylhamaudol, the compound showed analgesia by the tail pressure and the Randall & Selitto methods, and its writhing inhibition was not reversed by naloxone.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan. emi@p.chiba-u.ac.jp
authors.forename: E
authors.initials: E
authors.lastname: Okuyama
authors.forename: T
authors.initials: T
authors.lastname: Hasegawa
authors.forename: T
authors.initials: T
authors.lastname: Matsushita
authors.forename: H
authors.initials: H
authors.lastname: Fujimoto
authors.forename: M
authors.initials: M
authors.lastname: Ishibashi
authors.forename: M
authors.initials: M
authors.lastname: Yamazaki
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D013057:Spectrum Analysis
chemical_list: D018712:Analgesics, Non-Narcotic