[Changes in the hormonal function of the hypophysis-adrenal system by administration of cortisol in 'fixed' phases of the postnatal ontogenesis in rats].
Administration of cortisol on the 13th, 15th, and 17th days of postnatal ontogenesis was shown to exert a long-lasting modifying effect upon the hypophysis-adrenal system's (HAS) stress reactivity in the rat litter. The effect involved a longer duration of hormonal response to immobilisation stress: a longer-lasting elevation of the corticosterone level in the blood plasma suggesting a diminished sensitivity of the HAS to feed-back signal. In hippocampus, frontal cortex and hypothalamus of the experimental rats, a decrease in receptor binding of labeled corticosterone was revealed.
Ordian
N E
NE
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Pivina
S G
SG
Rakitskaia
V V
VV
Shaliapina
V G
VG
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism; D003345:Corticosterone / Q000097:blood* / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D007103:Immobilization; D066298:In Vitro Techniques; D008297:Male; D010913:Pituitary-Adrenal System / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D013315:Stress, Psychological / Q000378:metabolism; D013997:Time Factors
D011965:Receptors, Glucocorticoid; D003345:Corticosterone; D006854:Hydrocortisone
Izmenenie gormonal'noĭ funktsii gipofiz-adrenalovoĭ sistemy krys vvedeniem kortizola v "opredelennye periody" postnatal'nogo ontogeneza.