title: [A case of pulmonary manifestation associated with myelodysplastic syndrome].
abstract: A 69-year-old woman with myelodysplastic syndrome (MDS) was admitted to our hospital because of recurrent fever and pulmonary infiltration shadows. On the seventh day of hospitalization, she had an attack of high fever and cough and laboratory tests revealed an elevated leukocyte count and elevated serum C-reactive protein. Chest radiographs showed infiltration shadows in the right middle and lower lung fields. Because a diagnosis of bacterial pneumonia was initially suggested, she was treated with antibiotics. However, the infiltration shadows on the chest radiograph had not improve, so bronchofiberscopy was performed. Analysis of fluid obtained by bronchoalveolar lavage (BAL) showed an increase in the total cell count, predominantly in lymphocytes and neutrophils. A transbronchial biopsy specimen showed infiltration of numerous neutrophils with necrosis under the bronchial epithelium, and edematous septa were infiltrated with numerous neutrophils and lymphocytes. BAL, blood, urine, bone marrow, and sputum cultures were all free of bacteria, mycobacteria and fungi. Interstitial infiltration by numbers of neutrophils associated with MDS was diagnosed and steroid treatment was performed.
authors.affiliation: Second Department of Internal Medicine, Oita Medical University, Hasama-machi, Oita, 879-5593, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mito
authors.forename: Y
authors.initials: Y
authors.lastname: Yamakami
authors.forename: E
authors.initials: E
authors.lastname: Yamagata
authors.forename: T
authors.initials: T
authors.lastname: Yamasaki
authors.forename: K
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: H
authors.initials: H
authors.lastname: Nagai
authors.forename: M
authors.initials: M
authors.lastname: Nasu
mesh_terms: D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology; D017563:Lung Diseases, Interstitial / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008775:Methylprednisolone / Q000627:therapeutic use; D009190:Myelodysplastic Syndromes / Q000150:complications*; D009336:Necrosis; D020556:Neutrophil Infiltration; D011239:Prednisolone / Q000627:therapeutic use; D012061:Relapsing Fever / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D011239:Prednisolone; D008775:Methylprednisolone