[Immunocorrective effect of proteolytic enzymes on antibody genesis in mice subjected to infectious burn trauma and treatment with antibiotics].
As revealed in this study, massive burn trauma manifestly suppresses the genesis of antibodies to T-dependent antigen (sheep red blood cells). The administration of ampicillin to the burned animals enhances immunosuppression, while gentamicin produces no essential impact on immune processes under these conditions. Proteolytic enzymes, terrilytin and terridecase, have corrective influence on disturbances in immune response in animals with burns. Enzyme in the immobilized form (terridecase) has a more pronounced immunotropic activity in this type of pathology.
Khmelevskaia
I G
IG
State Medical University, Kursk, Russia.
D000667:Ampicillin / Q000627:therapeutic use; D000681:Amylases / Q000627:therapeutic use*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000917:Antibody Formation; D002056:Burns / Q000276:immunology* / Q000382:microbiology; D004338:Drug Combinations; D004800:Enzymes, Immobilized; D005839:Gentamicins / Q000627:therapeutic use; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D013211:Staphylococcus aureus; D014946:Wound Infection / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D004800:Enzymes, Immobilized; D005839:Gentamicins; C009402:amylase, phosphates, proteases drug combinations; D000667:Ampicillin; D000681:Amylases; D010447:Peptide Hydrolases
Immunokorregiruishchee deĭstvie proteoliticheskikh fermentov na antitelogenez u mysheĭ pri infitsirovannoĭ ozhogovoĭ travme i primenenii antibiotikov.