Treatment of chronic hypertension with intravenous enalaprilat and transdermal clonidine.
We report an 11-year-old boy with hypertension and chronic intestinal pseudo-obstruction, which renders him totally dependent on parenteral nutrition and prevents the use of oral medications. Here we report the feasibility of utilizing chronic i.v. enalaprilat and transdermal clonidine on a chronic basis to control hypertension. Over the last 10 months, the patient's hypertension has been well controlled by 1.25 mg i.v. enalaprilat every 8 h and a 0.2-mg clonidine patch every 6 days, with no apparent side-effects. There are no reports of i.v. enalaprilat usage exceeding 3 weeks' duration. Therefore we believe that it is possible to effect reasonable management of chronic hypertension with the use of chronic i.v. enalaprilat and transdermal clonidine therapy.
Zawaideh
M A
MA
Section of Pediatric Nephrology, Arizona Health Sciences Center, University of Arizona, 1501, N. Campbell Avenue, P.O. Box 245073, Tucson, AZ 85724, USA.
Duncan
B
B
Joseph
M W
MW
Dixit
M P
MP
D000279:Administration, Cutaneous; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002908:Chronic Disease; D003000:Clonidine / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015773:Enalaprilat / Q000008:administration & dosage* / Q000627:therapeutic use; D005240:Feasibility Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007275:Injections, Intravenous; D007418:Intestinal Pseudo-Obstruction / Q000150:complications / Q000628:therapy; D008297:Male; D010288:Parenteral Nutrition
D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D015773:Enalaprilat; D003000:Clonidine