A bi-allelic VNTR in the human TNFR2 (p75) gene promoter.
We describe a bi-allelic VNTR polymorphism within a 42 bp region in the promoter of the tumour necrosis factor receptor 2 gene (TNFR2). Within this region there are one (Allele 1) or two (Allele 2) repeats of a 15 bp sequence, 5'-GCCGGGC AGGTGGAG-3'. Allele frequencies observed in a Caucasian population were 0.3 (Allele 1) and 0.7 (Allele 2).
Keen
L
L
Division of Transplantation Sciences, University of Bristol, Homoeopathic Hospital Site, Cotham, Bristol, BS6 6JU, UK. J.Keen@bris.ac.uk
Wood
N
N
Olomolaiye
O
O
Bidwell
J
J
D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D001483:Base Sequence; D004247:DNA; D005260:Female; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic / Q000235:genetics*; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*; D047889:Receptors, Tumor Necrosis Factor, Type II; D012689:Sequence Homology, Nucleic Acid; D044465:White People / Q000235:genetics
D015703:Antigens, CD; D018124:Receptors, Tumor Necrosis Factor; D047889:Receptors, Tumor Necrosis Factor, Type II; D004247:DNA