title: Motor and sensory function of the rectum in different subtypes of constipation.
abstract: BACKGROUND
  It is not known whether evaluation of motor and sensory function of the rectum using a barostat may help to distinguish subtypes of constipation.
  
  
  METHODS
  Motor and sensory function of the rectum have been evaluated using a barostat in 14 patients with slow transit constipation (STC), 12 patients with constipation-predominant irritable bowel syndrome (IBS) and 18 healthy controls. First minimal distending pressure was determined, after which spontaneous adaptive relaxation of the rectum was monitored. Then a step-wise isobaric distension procedure was performed, during which symptom perception was determined. The distension was followed by a 90-min barostat procedure: for 30 min in the basal state followed by ingestion of a semi-liquid meal (postprandial state).
  
  
  RESULTS
  Minimal distending pressure was not different between both patient groups and controls, neither was compliance different between constipated patients and controls. The degree of spontaneous adaptive relaxation was in the same range in all groups. During distensions with high pressures, the perception of urge was significantly reduced in STC patients compared to IBS and controls, while the perception of pain was significantly increased in IBS versus STC and controls. Postprandially, a small decrease of rectal volume was only observed in the control group, but not in the patients.
  
  
  CONCLUSIONS
  Rectal motor characteristics are not different between patients with constipation-predominant IBS, patients with STC and healthy controls while during isobaric distensions, sensations of urge were reduced in STC and sensations of pain were increased in IBS. Rectal visceroperception testing may help distinguish groups of patients with different subtypes of constipation.
authors.affiliation: Dept of Gastroenterology-Hepatology and Surgery, Leiden University Medical Centre, The Netherlands.
authors.forename: C
authors.initials: C
authors.lastname: Penning
authors.forename: J
authors.initials: J
authors.lastname: Steens
authors.forename: P J
authors.initials: PJ
authors.lastname: van der Schaar
authors.forename: J
authors.initials: J
authors.lastname: Kuyvenhoven
authors.forename: J B
authors.initials: JB
authors.lastname: Delemarre
authors.forename: C B
authors.initials: CB
authors.lastname: Lamers
authors.forename: A A
authors.initials: AA
authors.lastname: Masclee
mesh_terms: D000328:Adult; D016022:Case-Control Studies; D003109:Colonic Diseases, Functional / Q000503:physiopathology*; D003248:Constipation / Q000145:classification / Q000503:physiopathology*; D005260:Female; D005772:Gastrointestinal Transit / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D019518:Postprandial Period; D011312:Pressure; D012007:Rectum / Q000294:innervation / Q000502:physiology*