title: The effect of 0.12% unoprostone isopropyl (rescula) on intraocular pressure in normotensive dogs.
abstract: Rescula (0.12% unoprostone isopropyl) is the first docosanoid compound approved for treatment of glaucoma in humans. It is commercially available in Japan, and is undergoing clinical testing elsewhere. The aim of this study was to evaluate the effect of Rescula on intraocular pressure (IOP) in normotensive dogs. After establishing a baseline diurnal IOP curve, six dogs were unilaterally treated with Rescula while the contralateral eye was treated with a placebo. Applanation tonometry was performed in both eyes, and pupil size was evaluated, 30 min after treatment, and at 1-hr intervals for the next 9 hr. Rescula caused a significant (p=0.014) and long-lasting decrease in IOP, from 20.49+/-2.02 mm Hg in control eyes to 15.49+/-0.69 mm Hg in treated eyes. These results suggest that Rescula is potentially efficacious in treatment of canine glaucoma.
authors.affiliation: Koret School of Veterinary Medicine, Hebrew University of Jerusalem, Rehovot, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Ofri
authors.forename: D
authors.initials: D
authors.lastname: Raz
authors.forename: P H
authors.initials: PH
authors.lastname: Kass
authors.forename: G N
authors.initials: GN
authors.lastname: Lambrou
authors.forename: C L
authors.initials: CL
authors.lastname: Percicot
mesh_terms: D000818:Animals; D015237:Dinoprost / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005227:Fatty Acids / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy / Q000662:veterinary*; D007429:Intraocular Pressure / Q000187:drug effects*; D009883:Ophthalmic Solutions; D011897:Random Allocation; D014065:Tonometry, Ocular / Q000662:veterinary
chemical_list: D005227:Fatty Acids; D009883:Ophthalmic Solutions; C072630:isopropyl unoprostone; D015237:Dinoprost; C007547:behenic acid