title: Myosin-V: head to tail.
abstract: The myosin-V family is the most extensively studied of the unconventional myosin families. Most organisms examined have at least one member of the myosin-V family: many have multiple members. The wide range of species in which myosin-V has been identified suggests that myosin-V is a fundamental component of organelle transport in all higher eukaryotes. Possible cargoes for myosin-V range from melanosomes and synaptic vesicles in mammals to vacuoles and messenger RNA in yeast. In this review, we discuss the current state of research on the cellular function of myosin-V as described by the actions of the head, neck and tail domains.
authors.affiliation: McLaughlin Research Institute, Great Falls, Montana 59405, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Provance
authors.forename: J A
authors.initials: JA
authors.lastname: Mercer
mesh_terms: D000818:Animals; D002148:Calmodulin-Binding Proteins / Q000235:genetics / Q000502:physiology; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology; D006801:Humans; D018995:Myosin Heavy Chains; D024461:Myosin Type I; D024462:Myosin Type II; D024701:Myosin Type V; D009218:Myosins / Q000235:genetics* / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D010802:Phylogeny; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins
chemical_list: D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D005656:Fungal Proteins; C077512:MYO2 protein, S cerevisiae; C434211:MYO2 protein, S pombe; C100412:MYO5 protein, S cerevisiae; D009419:Nerve Tissue Proteins; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; C078829:chicken brain myosin-V p190; D024461:Myosin Type I; D024462:Myosin Type II; D024701:Myosin Type V; D018995:Myosin Heavy Chains; D009218:Myosins