Nuclear import of arachidonate 5-lipoxygenase.
Leukotrienes are lipid messenger molecules that are secreted by leukocytes to orchestrate a rapid and prolonged immune response. The enzyme 5-lipoxygenase catalyzes the rate-limiting first two steps in the synthesis of leukotrienes from arachidonic acid. Although it has long been known that 5-lipoxygenase moves from the cytoplasm to a membrane following activation, it has only recently been recognized that the enzyme may shuttle into and out of the nucleus before activation. The regulation of this movement of soluble 5-lipoxygenase between the cytoplasm and the nucleoplasm, as well as its impact on 5-lipoxygenase action, leukotriene synthesis and cell function, is only now being elucidated. This review details the state of our understanding of the nuclear import of 5-lipoxygenase and its potential importance in immunity.
Brock
T G
TG
Department of Internal Medicine, University of Michigan, Ann Arbor 48109, USA. brocko@umich.edu
Healy
A M
AM
D000818:Animals; D001094:Arachidonate 5-Lipoxygenase / Q000276:immunology / Q000378:metabolism*; D001693:Biological Transport, Active; D002467:Cell Nucleus / Q000201:enzymology*; D003593:Cytoplasm / Q000201:enzymology; D004789:Enzyme Activation; D006801:Humans; D007962:Leukocytes / Q000201:enzymology / Q000276:immunology; D015289:Leukotrienes / Q000096:biosynthesis / Q000276:immunology / Q000378:metabolism
D015289:Leukotrienes; D001094:Arachidonate 5-Lipoxygenase