title: Sublethal concentration of Ambrosia maritima(Damsissa) affecting compatibility of Biomphalaria alexandrina snails to infection with Schistosoma mansoni through disturbing the glycolytic pathway.
abstract: High glycolytic flux as an emergency pathway for generating ATP was recorded as the most important metabolic pathway required for the success of Biomphalaria-Schistosome sporocyst interaction. Effect of LC25 of dry powdered Ambrosia maritima (Damsissa) as plant molluscicide on hexokinase (HK), pyruvate kinase(PK), glucose phosphate isomerase(GPI) was tested. It resulted in a significant inhibition of the three investigated enzymes. Treatment of snails with LC10 concentrations of A. maritima reduced considerably the infection rate of Biomphalaria alexandrina with Schistosoma mansoni to be 34% compared to an infection rate of 80% in control non-treated snails. Longer prepatent period and remarkable decrease in cercarial production was also recorded in snails treated with the sublethal concentrations of this molluscicide.
authors.affiliation: Department of Medicinal Chemistry, National Research Centre, Dokki, Giza, Egypt.
authors.forename: A
authors.initials: A
authors.lastname: el-Ansary
authors.forename: S
authors.initials: S
authors.lastname: el-Bardicy
authors.forename: M S
authors.initials: MS
authors.lastname: Soliman
authors.forename: N
authors.initials: N
authors.lastname: Zayed
mesh_terms: D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001700:Biomphalaria / Q000187:drug effects* / Q000469:parasitology*; D006019:Glycolysis / Q000187:drug effects*; D006593:Hexokinase / Q000378:metabolism; D006790:Host-Parasite Interactions / Q000187:drug effects*; D008975:Molluscacides / Q000008:administration & dosage / Q000494:pharmacology*; D010733:Phosphoglucomutase / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011770:Pyruvate Kinase / Q000378:metabolism; D012550:Schistosoma mansoni / Q000187:drug effects*
chemical_list: D008975:Molluscacides; D010936:Plant Extracts; D006593:Hexokinase; D011770:Pyruvate Kinase; D010733:Phosphoglucomutase