New potential photodynamic therapeutic anti-cancer agents: synthesis and characterization of demethoxy amino-substituted hypocrellins.
A novel method was used to obtain demethoxy amino-substituted hypocrellin derivatives. The reaction condition was mild and amino substitution occurred at position 2 or 11 of hypocrellins with high yield. The photophysical and photochemical properties of the amino-substituted hypocrellins derivatives were investigated, and their significantly enhanced red absorptivities and strong active oxygen-generating functions qualified them as promising photodynamic therapeutic anti-cancer agents.
Wu
T
T
Center for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing.
Xu
S
S
Shen
J
J
Song
A
A
Chen
S
S
Zhang
M
M
Shen
T
T
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004578:Electron Spin Resonance Spectroscopy; D006367:HeLa Cells; D006801:Humans; D019906:Nuclear Magnetic Resonance, Biomolecular; D010569:Perylene / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D019800:Phenol; D010777:Photochemistry; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011809:Quinones / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017382:Reactive Oxygen Species; D013481:Superoxides / Q000737:chemistry
D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011809:Quinones; D017382:Reactive Oxygen Species; D013481:Superoxides; D019800:Phenol; D010569:Perylene; C048388:hypocrellin A