Head lice resistance: itching that just won't stop.
OBJECTIVE
To evaluate the reports of resistance and cross-resistance to pediculicides in the head louse (Pediculus capitis), as well as the mechanisms involved.


METHODS
Literature identified through a MEDLINE search (1966-April 2000) and through other secondary literature databases and/or bibliographies of pertinent articles.


RESULTS
Head lice infestation is a common, worldwide problem. The widespread use of insecticide treatments together with inadequate treatment methods has led to a concern regarding the potential development of resistant head lice. This literature review examines the reports of resistance of the head louse as well as the purported mechanisms involved.


CONCLUSIONS
Current research suggests that head lice resistance exists, but little is known regarding the actual incidence of this resistance or whether this incidence is increasing. More research is needed to assess the status of this problem. Proposed mechanisms for head lice resistance include knock-down resistance, glutathione S-transferase-based resistance, and monooxygenase-based resistance.
Bartels
C L
CL
Department of Pharmacy Practice, School of Pharmacy & Allied Health Sciences, University of Montana, 32 Campus Dr., Missoula, MT 59812-1522, USA. bartels@selway.umt.edu
Peterson
K E
KE
Taylor
K L
KL
D000818:Animals; D006801:Humans; D007305:Insecticide Resistance; D007306:Insecticides / Q000627:therapeutic use*; D010373:Lice Infestations / Q000188:drug therapy* / Q000469:parasitology; D010374:Pediculus / Q000187:drug effects*; D011537:Pruritus / Q000188:drug therapy / Q000469:parasitology; D012196:Review Literature as Topic; D012536:Scalp Dermatoses / Q000188:drug therapy* / Q000469:parasitology
D007306:Insecticides