title: Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans.
authors.affiliation: Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20851, USA.
authors.forename: L J
authors.initials: LJ
authors.lastname: Lesko
authors.forename: M
authors.initials: M
authors.lastname: Rowland
authors.forename: C C
authors.initials: CC
authors.lastname: Peck
authors.forename: T F
authors.initials: TF
authors.lastname: Blaschke
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D010599:Pharmacokinetics; D010601:Pharmacology, Clinical / Q000379:methods*