[Effects of verapamil and gynipral on the uterine contractile activity in rats].
Verapamil and gynipral administered to pregnant rats in doses on a clinical level suppress the uterine contractions, which is manifested by a decrease in the amplitude and frequency of the biopotential. The joint administration of gynipral and verapamil (in half doses) resulted in a pronounced tocolytic effect.
Kaplenko
O V
OV
Laboratory of Pharmacology, Ott Institute of Obstetrics and Gynecology, Russian Academy of Medical Sciences, Mendeleevskaya Liniya 3, St. Petersburg, 199034 Russia.
Korkhov
V V
VV
Lesik
E A
EA
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006594:Hexoprenaline / Q000494:pharmacology*; D009215:Myometrium / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D015149:Tocolytic Agents / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D000318:Adrenergic beta-Agonists; D002121:Calcium Channel Blockers; D015149:Tocolytic Agents; D014700:Verapamil; D006594:Hexoprenaline
Vliianie verapamila i giniprala na sokratitel'nuiu deiatel'nost' matki krys.