title: Squamous cell carcinoma of the temporal bone: diagnosis, treatment and prognosis.
abstract: Squamous cell carcinoma of the external ear canal is an uncommon condition that is associated with a poor outcome. The development of an accepted staging system has not been forthcoming and this has inhibited the formation of an evidence-based therapeutic protocol. We report the findings in 14 patients with squamous cell carcinoma of the external ear canal treated in our institutions. The most common presenting symptoms were otorrhoea and otalgia. Four patients had a history of chronic ear discharge and one had previous radiotherapy for nasopharyngeal carcinoma. Five patients had facial palsy which was a poor prognostic sign. Only one patient had clinical neck disease. Pre-operative imaging with CT or MRI scans was accurate in determining the extent of tumour involvement. The initial T-staging relied heavily on these findings. With combination treatment involving surgery, radiotherapy and chemotherapy, disease free survival achieved was 69% (9 of 13) over a mean follow-up period of 24.7 months. One patient absconded treatment. Patients with early stage tumours faired better than patients with advanced tumours (100% vs 33%). There was low incidence of involvement of the parotid gland (1 of 7 patients). Patients with facial nerve involvement had a significantly poorer outcome (p = 0.035).
authors.affiliation: Department of Otolaryngology, National University Hospital, Singapore 119074. entv3@nus.edu.sg
authors.forename: G
authors.initials: G
authors.lastname: Chee
authors.forename: P
authors.initials: P
authors.lastname: Mok
authors.forename: R
authors.initials: R
authors.lastname: Sim
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012888:Skull Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D013701:Temporal Bone / Q000473:pathology*; D016896:Treatment Outcome