title: Bioavailability of water- and lipid-soluble thiamin compounds in broiler chickens.
abstract: The bioavailability of thiamin mononitrate, thiamin chloride-hydrochloride and benfotiamin was compared in broiler chickens. A thiamin-deficient diet was supplemented with either 1.8 and 1.5 mg/kg thiamin equivalent as water-soluble salts, or with 1.5 and 1.2 mg/kg thiamin equivalent as benfotiamin, respectively, and fed to 3 replicate groups/treatment for 21 days. Weight gain, feed consumption and feed conversion rate were not significantly affected by solubility or dietary level of thiamin. Likewise, using biochemical indices of thiamin status (erythrocyte transketolase activation coefficient, and thiamin concentrations in blood and liver), no differences were found between the water-soluble thiamin salts, indicating that they have identical potency. In contrast, biochemical indices of thiamin status showed a significantly higher bioavailability for benfotiamin than for the water-soluble sources.
authors.affiliation: Institute of Nutritional Sciences, University of Giessen, Wilhelmstr. 20, D-35392 Giessen.
authors.forename: J
authors.initials: J
authors.lastname: Geyer
authors.forename: M
authors.initials: M
authors.lastname: Netzel
authors.forename: I
authors.initials: I
authors.lastname: Bitsch
authors.forename: T
authors.initials: T
authors.lastname: Frank
authors.forename: R
authors.initials: R
authors.lastname: Bitsch
authors.forename: K
authors.initials: K
authors.lastname: Krämer
authors.forename: P P
authors.initials: PP
authors.lastname: Hoppe
mesh_terms: D000818:Animals; D001682:Biological Availability; D002645:Chickens / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000201:enzymology; D008055:Lipids; D008297:Male; D012995:Solubility; D013831:Thiamine / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics*; D014174:Transketolase / Q000097:blood; D014867:Water
chemical_list: D008055:Lipids; D014867:Water; D014174:Transketolase; D013831:Thiamine; C013835:benphothiamine