Endothelial and epithelial expression of sialyl Lewis(x) in squamous carcinoma of the tongue.
In this retrospective study we describe the immunohistochemical expression pattern of sLe(x) epitopes in endothelial and epithelial cells of 59 squamous carcinomas of the tongue, and relate this to the relative survival rates of the patients. Endothelial sLe(x) expression was significantly elevated in malignant lesions compared to normal tissues, but did not have any prognostic value for the relative survival rate. In contrast, epithelial sLe(x) expression was decreased in carcinomas compared to normal tongue. The patients whose carcinoma showed only moderate epithelial HECA-452 reactivity had a significantly better relative survival rate than the patients with tumor specimens with neglible or very high HECA-452 reactivity. The epithelial staining with the two other anti-sLe(x) antibodies (CSLEX-1 and 2F3) did not correlate with the survival rates of tongue carcinoma patients.
Renkonen
J
J
Department of Bacteriology and Immunology, University of Helsinki, Finland. Jutta.Renkonen@Helsinki.Fi
Heinävaara
S
S
Sankila
R
R
Paavonen
T
T
D000911:Antibodies, Monoclonal / Q000378:metabolism; D002240:Carbohydrate Sequence; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000378:metabolism* / Q000401:mortality; D004727:Endothelium / Q000276:immunology / Q000378:metabolism; D004848:Epithelium / Q000276:immunology / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008969:Molecular Sequence Data; D009362:Neoplasm Metastasis; D009844:Oligosaccharides / Q000737:chemistry / Q000378:metabolism*; D011379:Prognosis; D012189:Retrospective Studies; D000080506:Sialyl Lewis X Antigen; D015996:Survival Rate; D014062:Tongue Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000401:mortality
D000911:Antibodies, Monoclonal; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen