Pulmonary nocardiosis during immunosuppressive therapy for idiopathic pulmonary fibrosis.
Nocardiosis is a subacute or chronic suppurative infection caused by Nocardia species. Although it is more common in immunocompromised hosts, idiopathic pulmonary fibrosis (IPF) has not been recognized as a predisposing factor for nocardial infection. We report a case of IPF, in which pulmonary nocardiosis developed during treatment with prednisolone and cyclophosphamide. The risk of pulmonary nocardiosis may be increased in cases of IPF on immunosuppressive therapy. Since IPF often accompanies lung carcinoma, it is important to correctly differentiate nocardiosis from carcinoma.
Maeno
Y
Y
Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Sando
Y
Y
Ubukata
M
M
Maeno
T
T
Tajima
S
S
Hosono
T
T
Sato
M
M
Tsukagoshi
M
M
Suga
T
T
Kurabayashi
M
M
Nagai
R
R
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D015984:Causality; D003520:Cyclophosphamide / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D008911:Minocycline / Q000627:therapeutic use; D009617:Nocardia Infections / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology; D018410:Pneumonia, Bacterial / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000382:microbiology; D011239:Prednisolone / Q000009:adverse effects*; D011658:Pulmonary Fibrosis / Q000188:drug therapy* / Q000276:immunology; D013183:Sputum / Q000382:microbiology; D014057:Tomography, X-Ray Computed
D000900:Anti-Bacterial Agents; D007166:Immunosuppressive Agents; D003520:Cyclophosphamide; D011239:Prednisolone; D008911:Minocycline