title: The synthesis of deuterionucleosides.
abstract: The synthesis of deuterionucleosides for site-specific incorporation into oligo-DNA or -RAA is herein reviewed for NMR or biological studies. The review covers the following aspects: (i) deuteration of the aglycone; (ii) single-site chemical deuteration of the sugar residues; (iii) multiple-site chemical deuteration of the sugar residues; (iv) enzymatic synthesis of deuterated nucleosides or nucleotides; and (v) synthesis of labelled nucleosides with multiple isotopes
authors.affiliation: Department of Bioorganic Chemistry, Biomedical Center, University of Uppsala, Sweden. andras@bioorgchem.uu.se
authors.forename: A
authors.initials: A
authors.lastname: Földesi
authors.forename: A
authors.initials: A
authors.lastname: Trifonova
authors.forename: M K
authors.initials: MK
authors.lastname: Kundu
authors.forename: J
authors.initials: J
authors.lastname: Chattopadhyaya
mesh_terms: D003903:Deuterium / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009705:Nucleosides; D003903:Deuterium