Pre-clinical experimental studies of indomethacin-releasing copper intrauterine device.
Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu2+ releasing amounts of both IUDs in vitro were observed. The results showed that the inhibiting action of the indomethacin-releasing copper IUD (FICu-IUD) on the PGI2 was stronger than that on the TXA2, the ratio of 6-keto-PGF1 alpha/TXB2 was reduced with the increase of the doses. There were significant differences between the groups. The FICu-IUD could inhibit the rising of the ET level and lighten the endometrial impairment caused by the FCu-IUD, and promote copper ion release. It was suggested that indomethacin released by FICu-IUD could effectively reduce abnormal uterine bleeding.
Cao
L
L
Family Planning Research Institute, Tongji Medical University, Wuhan 430030.
Zhou
Y
Y
Liu
Z
Z
Du
Q
Q
Li
W
W
Hu
Y
Y
Li
W
W
D000818:Animals; D003300:Copper / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism / Q000473:pathology; D019332:Endothelin-1 / Q000378:metabolism; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage*; D007435:Intrauterine Devices, Copper; D011453:Prostaglandins / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
D019332:Endothelin-1; D011453:Prostaglandins; D003300:Copper; D007213:Indomethacin