High curvature and jerk analyses of arm ataxia.
We investigated high curvature analysis (HCA) and integrated absolute jerk (IAJ) for differrentiating healthy and cerebellopathy (CB) patients performing pointing tasks. Seventeen CB patients and seventeen healthy controls were required to move a pointer at their preferred pace between two 50.8 cm laterally spaced targets while standing with theirarm extended in front of their body. HCA was used to quantify the frequency of sharp turns in the horizontal-plane (anterior-posterior and medio-lateral) velocity trajectory of the hand-held pointer. IAJ was assesssed by integration of absolute jerk (second time derivative of velocity) time histories in the anterior-posterior and medio-lateral directions. HCA scores and IAJ scores were then compared between CB patients and healthy controls; for both analyses, higher scores indicateless smooth movements. We hypothesized that CB patients would have less smooth movement trajectories than healthy controls due to upper extremity ataxia asssociated with cerebellar disease and degeneration. We found that CB patients had higher HCA scores than healthy controls (P = 0.014). Although CB patients had higher IAJ scores in both anterior-posterior (P = 0.060)and medio-lateral (P = 0.231) directions compared to the healthy controls, the differences were not significant. The difference in sensitivity between the HCA andthe IAJ analysis might be explained by primitive neural activation commands, ubiquitous though only evident with some cerebellar dysfunctions, which produce submovements which are themselves minimal jerk curves. We conclude that HCA may be a useful tool for quantifying upper extremity ataxia in CB patients performing a repeated pointing task.
Goldvasser
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Massachusetts General Hospital, Biomotion Laboratory, Boston 02114, USA. dov@gaitalf.mgh.harvard.edu
McGibbon
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CA
Krebs
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D000328:Adult; D001132:Arm / Q000502:physiology* / Q000503:physiopathology*; D001259:Ataxia / Q000503:physiopathology*; D016022:Case-Control Studies; D002526:Cerebellar Diseases / Q000503:physiopathology*; D006801:Humans; D008875:Middle Aged; D009068:Movement