[Comparison of in vitro model examinaitons with respect to drug release from suppositories].
9 lipophilic suppository bases with different physical-chemical parameters were examined. Buspiron-hydrochloride, an anxiolytic drug with good water-solubility was used--partly as a model--as a pharmacon, in a concentration of 10.0 mg/2.00 g. The rate and extent of in vitro drug release was monitored with static and dynamic methods. Kidney-dialysing membranes with various surfaces were used. The quantitative measurements were carried out spectrophotometrically and the amount of the diffused drug was determined at lambda = 298 nm. The mean values were calculated from 5 parallel measurements each time. The percentage values of in vitro relative availability revealed that the results of the two static diffusion studies did not differ significantly (p < 0.05) and were almost independent of the size of the membrane surface. The results of the dynamic diffusion method were well-reproducible but were vehicle-dependent. The process of release was characterized by the mathematical transformation of the release curves, while the correlation coefficients described the closeness of the relation. Two German vehicles, namely Witepsol H 15 with a medium hydroxyl value and Massa Estarinum 299, and a French vehicle, Suppocire AS2X were found to be excellent for the formulation of suppositories containing Buspiron-hydrochloride.
Regdon
G
G
Szegedi Tudományegyetem, Gyógyszerésztudományi Kar, Gyógyszertechnológiai Intézet, Szeged, Eötvös u. 6.-6720.
Vágó
I
I
Mándi
E
E
Regdon
G
G
Erós
I
I
D014151:Anti-Anxiety Agents; D002065:Buspirone; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D013488:Suppositories
D014151:Anti-Anxiety Agents; D003692:Delayed-Action Preparations; D008567:Membranes, Artificial; D013488:Suppositories; D002065:Buspirone
In vitro vizsgálati modellek eredményeinek összehasonlítása a kúpok hatóanyagleadása szempontjából.