Monitoring of p53 autoantibodies after resection of colorectal cancer: relationship to operative curability.
OBJECTIVE
To investigate the clinical use of p53 autoantibodies as a marker in the postoperative monitoring of colorectal cancer.


METHODS
Retrospective study.


METHODS
Teaching hospital, Japan.


METHODS
40 patients with colorectal cancer who had p53 autoantibodies in their serum preoperatively.


METHODS
Serial assay of p53 autoantibodies by ELISA before and after resection.


METHODS
Interpretation by a qualitative analysis.


RESULTS
A significant correlation was observed between curability by surgical resection and postoperative disappearance of p53 autoantibodies. Twenty-seven (96%) of 28 patients, who had p53 autoantibodies and whose cancer was completely removed, had no such antibodies after resection and no recurrence after 7 to 26 months.


CONCLUSIONS
Postoperative assays of p53 autoantibodies are potentially useful for predicting recurrence of colorectal cancer in patients who have p53 autoantibodies preoperatively.
Takeda
A
A
Second Department of Surgery, School of Medicine, Chiba University, Japan.
Shimada
H
H
Nakajima
K
K
Imaseki
H
H
Suzuki
T
T
Asano
T
T
Ochiai
T
T
Isono
K
K
D015179:Colorectal Neoplasms / Q000276:immunology* / Q000601:surgery; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015166:Monitoring, Immunologic; D011237:Predictive Value of Tests; D012008:Recurrence; D012189:Retrospective Studies; D016159:Tumor Suppressor Protein p53 / Q000097:blood*
D016159:Tumor Suppressor Protein p53