title: [Cytokines and the liver in health and disease].
abstract: Cytokines are a group of proteins with autocrine, paracrine and endocrine activities which provide communication among hepatic cells and other cells and tissues of the man. Active in minute quantities, the cytokines activate and regulate homeostasis and cellular repair through effects on cell growth, differentiation and receptor expression and cell-mediated immunity. Cytokines--IL-1, IL-2, IL-6, IL-8 IL-10, IL-12, TNF-alfa, PDGF and others, modulate liver metabolism in health and disease, physiological and pathologic liver functions and the evolution of liver inflammation and injury to hepatic fibrosis and liver cirrhosis. Data concerning the use of a recombinant form of Interleukin-10 and Interleukin-12 in the treatment of chronic liver disease (chronic viral hepatitis, fibrosis, cirrhosis, alcoholic liver disease) and cell-mediated immunity regulation are widely discussed in the review.
authors.forename: V
authors.initials: V
authors.lastname: Kolarski
authors.forename: A
authors.initials: A
authors.lastname: Todorov
authors.forename: D
authors.initials: D
authors.lastname: Petrova
mesh_terms: D016207:Cytokines / Q000378:metabolism*; D006521:Hepatitis, Chronic / Q000276:immunology / Q000503:physiopathology* / Q000628:therapy; D006801:Humans; D007111:Immunity, Cellular; D007372:Interferons / Q000378:metabolism* / Q000627:therapeutic use; D007378:Interleukins / Q000378:metabolism* / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism*
chemical_list: D016207:Cytokines; D007378:Interleukins; D007372:Interferons
vernacular_title: Tsitokini i cheren drob pri zdrave i bolest.