Temperature set-point changes induced by DA D2/3 and 5-HT1A receptor agonists in the rat.
The DA D2/3 receptor agonist 7-OH-DPAT (2 micromol kg(-1)) and the 5HT1A receptor agonist 8-OH-DPAT (0.6 micromol kg(-1)) both produced a marked and similar decrease in core temperature of 3-4 degrees C at 10 and 20 degrees C ambient temperature. At 30 degrees C there were no, or weak, effects. The decrease in core temperature was accompanied by a sudden increase in tail temperature, followed by a decrease as core temperature returned to basal values. The results suggest that the hypothermia produced by the respective DA D2/3 and the 5-HT1A receptor agonists 7-OH-DPAT and 8-OH-DPAT is an active process, in all probability due to changes in a hypothalamic set-point for temperature regulation.
Oerther
S
S
Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects* / Q000502:physiology*; D018491:Dopamine Agonists / Q000494:pharmacology; D007035:Hypothermia / Q000139:chemically induced / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000819:agonists* / Q000378:metabolism; D050637:Receptors, Dopamine D3; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D018491:Dopamine Agonists; C493595:Drd3 protein, rat; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists; D013764:Tetrahydronaphthalenes; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; C031349:7-hydroxy-2-N,N-dipropylaminotetralin