Chemopreventive effects of coffee bean and rice constituents on colorectal carcinogenesis.
Polyphenolic compound chlorogenic acid (CGA) known to be much contained in coffee beans was found to have a regressive effect on induced aberrant crypt foci (ACF) as well as on development of ACF in azoxymethane (AOM)-induced colorectal carcinogenesis in rats. Rice germ and gamma-aminobutyric acid-enriched defatted rice germ inhibited AOM-induced ACF formation and colorectal carcinogenesis in rats. Ferulic acid (FA) also known to be contained in coffee beans and rice prevented AOM-induced ACF formation and intestinal carcinogenesis in rats. Both of food factors, coffee and rice may be of benefit to prevention of human colorectal cancers.
Mori
H
H
Department of Pathology, Gifu University School of Medicine, Japan.
Kawabata
K
K
Matsunaga
K
K
Ushida
J
J
Fujii
K
K
Hara
A
A
Tanaka
T
T
Murai
H
H
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001391:Azo Compounds; D018890:Chemoprevention; D002726:Chlorogenic Acid / Q000627:therapeutic use; D003069:Coffee / Q000737:chemistry / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D003373:Coumaric Acids / Q000627:therapeutic use; D006801:Humans; D012275:Oryza / Q000737:chemistry; D008517:Phytotherapy
D016588:Anticarcinogenic Agents; D001391:Azo Compounds; D003069:Coffee; D003373:Coumaric Acids; D002726:Chlorogenic Acid; C001825:azomethane; C004999:ferulic acid