Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation.
Since the discovery 13 years ago of interleukin (IL)-8 as a potent neutrophil chemotactic factor, accumulating evidence has established it as a crucial mediator in neutrophil-dependent acute inflammation. Numerous observations have demonstrated that various types of cells can produce a large amount of IL-8, either in response to various stimuli or constitutively, after malignant transformation. Recent studies of IL-8-mediated signaling have revealed that IL-8 activates a wide range of signaling molecules in a coordinate manner. IL-8 has been proven to have diverse actions on various types of leukocytic and nonleukocytic cells besides neutrophils. The author reviews recent progress in IL-8 signal transduction and biological actions on nonneutrophilic leukocytes, including T lymphocytes, monocytes, and hematopoietic progenitor cells. Potential involvement of IL-8 in viral infections and tumor progression is also discussed.
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Division of Molecular Bioregulation, Department of Molecular Oncology, Cancer Research Institute, Kanazawa University, Kanazawa, Japan. naofumim@kenroku.kanazawa-u.ac.jp
D002450:Cell Communication / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D016209:Interleukin-8 / Q000502:physiology*; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology; D018375:Neutrophil Activation / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects
D016209:Interleukin-8