[Hydrogen peroxide--a marker for respiratory tract inflammation in patients with bronchial asthma].
OBJECTIVE
To test H2O2 as a marker of respiratory tract inflammation in patients with bronchial asthma (BA).


METHODS
The study entered 70 patients (20 males and 50 females) with atopic asthma (AA) aged 18 to 62 years (mean age 32.6 years). H2O2 concentration in the expired air (CEA) was determined spectrophotometrically (Gallati & Pracht, 1985), content of eosinophilic cationic protein (ECP) in blood--with radioimmunoassay kits (Pharmacia & Upjohn, Sweden). Forced expiratory volume per 1 second (FEV1) was used for assessment of severity of bronchial obstruction. Bronchial hyperreactivity was studied by means of the histamine bronchoprovocative test.


RESULTS
H2O2 in CEA in BA patients was higher than in healthy subjects (0.127 +/- 0.010 microm/l vs 0.024 +/- 0.004 microm/l). H2O2 concentration significantly correlates with FEV1 (r = -0.449; p < 0.001), bronchial hyperreactivity to histamine (rs = -0.382; p < 0.05) and ECP in blood plasma(r = 0.625; p < 0.01).


CONCLUSIONS
It was proved possible to use H2O2 in CEA for evaluation of respiratory inflammation in BA patients.
Emel'ianov
A V
AV
Shcherbak
I G
IG
Abulimiti
A
A
Krasnoshchekova
O I
OI
Sinitsyna
T M
TM
Rudinskiĭ
K A
KA
Fedulov
A V
AV
Karabanov
A V
AV
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D001798:Blood Proteins / Q000032:analysis; D001944:Breath Tests; D001985:Bronchial Provocation Tests; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000737:chemistry; D005260:Female; D006801:Humans; D006861:Hydrogen Peroxide / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012137:Respiratory System / Q000473:pathology*; D012260:Ribonucleases
D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D006861:Hydrogen Peroxide; D012260:Ribonucleases
Perekis' vodoroda kak marker vospaleniia dykhatel'nykh puteĭ u bol'nykh bronkhial'noĭ astmoĭ.