[Fibronectin as a diagnostic marker in several determined neurological diseases].
OBJECTIVE
To determinate if fibronectin in CSF can be a useful parameter in the diagnosis of some neurologic illnesses.


METHODS
We have studied 30 patients, subdivided in four groups, depending on the type of neurologic illness. We have chosen as control a 10-patient group, which came to the Emergency Service and were diagnosed as a suspicious of neurologic illness, but after this it was discarded. In the whole group we practiced a lumbar puncture, with cytology, systematic, biochemistry, cultures, immunoglobulins determination and fibronectin quantification by ELISA.


RESULTS
We want to emphasize the increase in fibronectin levels in CSF in both the patients with bacterial meningitis and the multiple sclerosis groups, when it's compared with the control group.


CONCLUSIONS
For this, the determination of fibronectin levels in CSF might be a useful parameter in the diagnosis of some neurologic illnesses.
Merino García
L C
LC
Servicio de Medicina Interna, Hospital Universitario, Valladolid.
González Sarmiento
E
E
Rubio del Val
M C
MC
Ergueta Martín
P
P
Hinojosa Mena-Bernal
M C
MC
Fernández Martínez
I
I
Marañón Cabello
A
A
D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D016022:Case-Control Studies; D005353:Fibronectins / Q000134:cerebrospinal fluid*; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D011559:Pseudotumor Cerebri / Q000134:cerebrospinal fluid
D015415:Biomarkers; D005353:Fibronectins
Fibronectina como marcador diagnóstico de determinadas enfermedades neurológicas.