title: [Clinical aspects, course and extrahepatic manifestations of hepatitis C].
abstract: Hepatitis C virus infection occasionally causes acute icteric hepatitis. However, primary infection is usually asymptomatic. Viral clearance occurs only in 20%; most patients develop a chronic hepatitis, which tends to be hardly symptomatic for many years. The risk of progression to cirrhosis, hepatocellular carcinoma and end-stage liver disease is associated with the severity of histopathological changes, and is increased by additional factors, such as excessive alcohol intake or coinfection with hepatitis B virus and HIV. Immunologically mediated extrahepatic manifestations of hepatitis C, in particular essential mixed cryoglobulinemia, can often be observed. Occasionally, they lead to fatal complications.
authors.affiliation: 2. Medizinische Abteilung des Donauspitals im SMZ-Ost der Stadt Wien, Langobardenstrasse 122, A-1220 Wien. gerold.hartmann@smz.magwien.gv.at
authors.forename: G
authors.initials: G
authors.lastname: Hartmann
authors.forename: E B
authors.initials: EB
authors.lastname: Ben Ramadar
authors.forename: G
authors.initials: G
authors.lastname: Hübl
authors.forename: C
authors.initials: C
authors.lastname: Sebesta
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis; D015897:Comorbidity; D006509:Hepatitis B / Q000175:diagnosis; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis*; D019698:Hepatitis C, Chronic / Q000175:diagnosis; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis; D008113:Liver Neoplasms / Q000175:diagnosis; D012307:Risk Factors
vernacular_title: Klinik, Verlauf und extrahepatische Manifestationen der Hepatitis C.