Generation of cytotoxic T lymphocytes and cytostatic acting cells in T. annulata-immune cattle.
Cattle immunized against Theileria annulata with schizont containing autologous cell lines are immune to challenge with a homologous parasite strain. Two cell types have been detected in the peripheral blood of the immunized animals: cytotoxic T lymphocytes (CTL) and cytostatic acting cells (CAC). Killing the target cells by CTL is infection associated and is MHC class I restricted. Hence, no cytotoxicity was observed against target cells that were treated with the theilericidal drug buparvaquone or autologous Con A-blasts. The growth inhibition of CAC is MHC unrestricted, and not mediated by cytokine interferon gamma (IFN-gamma).
Ahmed
J S
JS
Forschungszentrum Borstel, Parkallee 22, 23845 Borstel, Germany. jahmed@fz-borstel.de
Wiegers
P
P
Ritz
H
H
Hartwig
H
H
Schein
E
E
Schnittger
L
L
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology; D003208:Concanavalin A; D003602:Cytotoxicity, Immunologic; D007371:Interferon-gamma / Q000494:pharmacology; D008213:Lymphocyte Activation; D011994:Recombinant Proteins; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects / Q000276:immunology* / Q000469:parasitology*; D016796:Theileria annulata / Q000276:immunology*; D013801:Theileriasis / Q000276:immunology*
D011994:Recombinant Proteins; D003208:Concanavalin A; D007371:Interferon-gamma