[Apoptosis and proliferation of epithelial cells in papillomaviral and chlamydial cervicitis].
Patients with chlamydial and papillomaviral cervicitis show a significantly higher activity of the ectocervical epithelium which is particularly pronounced in papillomaviral infection. This is, however, matched by progressively reduced apoptosis of epithelial cells which in turn suggests the possibility of papillomaviruses and chlamydiae contributing to inhibition of infected cells and, thus, paving the way for development of precancer and cancer of cervix uteri.
Vaganova
I G
IG
State Medical Academy, Diagnostical Center, Omsk.
D000328:Adult; D017209:Apoptosis; D002455:Cell Division; D002690:Chlamydia Infections / Q000473:pathology*; D004847:Epithelial Cells / Q000737:chemistry / Q000473:pathology*; D005260:Female; D015964:Gene Expression Regulation, Bacterial; D015967:Gene Expression Regulation, Viral; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014412:Tumor Virus Infections / Q000473:pathology*; D002575:Uterine Cervicitis / Q000382:microbiology / Q000473:pathology* / Q000821:virology
D018809:Proliferating Cell Nuclear Antigen; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53
Apoptoz i proliferatsiia épiteliotsitov éktotserviksa u bol'nykh papillomavirusnym i khlamidiĭnym tservitsitom.