Impaired dentofacial development after radiotherapy of a non-Hodgkin lymphoma: report of case.
Since the advances in therapy of childhood malignancies have improved life expectancy attention is now increasingly focused on the long-term effects of antineoplastic therapy. Developmental abnormalities due to antineoplastic therapy have been claimed to preferentially occur in children treated before the age of six years. This report of a case demonstrates severe developmental disturbances following radiotherapy of a cervical non-Hodgkin lymphoma at the age of eight years. The morphological changes included microdontia, root shortening, blunting and thinning as well as mandibular hypoplasia.
Folwaczny
M
M
Department of Restorative Dentistry and Periodontology, Ludwig-Maximilians University, Munich, Germany.
Hickel
R
R
D000328:Adult; D002648:Child; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000532:radiotherapy*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy*; D008297:Male; D008310:Malocclusion / Q000209:etiology; D008334:Mandible / Q000002:abnormalities* / Q000528:radiation effects; D011832:Radiation Injuries / Q000209:etiology*; D014071:Tooth Abnormalities / Q000209:etiology*; D019228:Tooth Crown / Q000002:abnormalities / Q000528:radiation effects; D014092:Tooth Root / Q000002:abnormalities / Q000528:radiation effects