Inhibition of DNA replication in camptothecin-treated cells is regulated by protein kinases.
Zhou
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Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA.
Wang
Y
Y
D000730:Androstadienes / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D064007:Ataxia Telangiectasia Mutated Proteins; D002110:Caffeine / Q000494:pharmacology; D002166:Camptothecin / Q000494:pharmacology*; D018797:Cell Cycle Proteins; D004249:DNA Damage; D004261:DNA Replication / Q000187:drug effects* / Q000502:physiology; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D009154:Mutation; D009687:Nuclear Proteins; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D016196:S Phase / Q000187:drug effects / Q000502:physiology; D025521:Tumor Suppressor Proteins; D000077191:Wortmannin
D000730:Androstadienes; D000972:Antineoplastic Agents, Phytogenic; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D004791:Enzyme Inhibitors; D009687:Nuclear Proteins; D010726:Phosphodiesterase Inhibitors; D025521:Tumor Suppressor Proteins; D002110:Caffeine; C576324:ATM protein, human; C576597:ATR protein, human; D064007:Ataxia Telangiectasia Mutated Proteins; D051747:DNA-Activated Protein Kinase; C497263:PRKDC protein, human; D017346:Protein Serine-Threonine Kinases; D002166:Camptothecin; D000077191:Wortmannin