title: Is physical deconditioning a perpetuating factor in chronic fatigue syndrome? A controlled study on maximal exercise performance and relations with fatigue, impairment and physical activity.
abstract: BACKGROUND
  Chronic fatigue syndrome (CFS) patients often complain that physical exertion produces an increase of complaints, leading to a greater need for rest and more time spent in bed. It has been suggested that this is due to a bad physical fitness and that physical deconditioning is a perpetuating factor in CFS. Until now, studies on physical deconditioning in CFS have shown inconsistent results.
  
  
  METHODS
  Twenty CFS patients and 20 matched neighbourhood controls performed a maximal exercise test with incremental load. Heart rate, blood pressure, respiratory tidal volume, O2 saturation, O2 consumption, CO2 production, and blood-gas values of arterialized capillary blood were measured. Physical fitness was quantified as the difference between the actual and predicted ratios of maximal workload versus increase of heart rate. Fatigue, impairment and physical activity were assessed to study its relationship with physical fitness.
  
  
  RESULTS
  There were no statistically significant differences in physical fitness between CFS patients and their controls. Nine CFS patients had a better fitness than their control. A negative relationship between physical fitness and fatigue was found in both groups. For CFS patients a negative correlation between fitness and impairment and a positive correlation between fitness and physical activity was found as well. Finally, it was found that more CFS patients than controls did not achieve a physiological limitation at maximal exercise.
  
  
  CONCLUSIONS
  Physical deconditioning does not seem a perpetuating factor in CFS.
authors.affiliation: Department of Medical Psychology, University of Nijmegen, The Netherlands.
authors.forename: E
authors.initials: E
authors.lastname: Bazelmans
authors.forename: G
authors.initials: G
authors.lastname: Bleijenberg
authors.forename: J W
authors.initials: JW
authors.lastname: Van Der Meer
authors.forename: H
authors.initials: H
authors.lastname: Folgering
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D016022:Case-Control Studies; D005080:Exercise Test; D005221:Fatigue; D015673:Fatigue Syndrome, Chronic / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D010809:Physical Fitness; D012720:Severity of Illness Index