Quinolactacins A, B and C: novel quinolone compounds from Penicillium sp. EPF-6. I. Taxonomy, production, isolation and biological properties.
Quinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have been found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid Margaronia pyloalis Welker). The fungal strain, EPF-6 was identified as Penicillium sp. from its morphological characteristics. Quinolactacins were obtained from the culture medium by solvent extraction and chromatographic purification. Compound 1 showed inhibitory activity against tumor necrosis factor (TNF) production induced by murine peritoneal macrophages and macrophage-like J774.1 cells stimulated with lipopolysaccharide (LPS).
Kakinuma
N
N
United Graduate School of Agricultural Science, Tokyo  University of Agriculture and Technology, Fuchu, Japan.
Iwai
H
H
Takahashi
S
S
Hamano
K
K
Yanagisawa
T
T
Nagai
K
K
Tanaka
K
K
Suzuki
K
K
Kirikae
F
F
Kirikae
T
T
Nakagawa
A
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry* / Q000648:ultrastructure; D015363:Quinolones / Q000138:chemical synthesis / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis
D000900:Anti-Bacterial Agents; D015363:Quinolones; D014409:Tumor Necrosis Factor-alpha; C420723:quinolactacin A; C420724:quinolactacin B; C420725:quinolactacin C