FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. II. Biological properties.
FR191512, a novel polyphenolic compound, inhibited the infectivity of influenza A virus in Madin-Darby canine kidney (MDCK) cells in vitro. Furthermore, FR191512 showed good in vivo anti-influenza activity in a mouse model of intranasal infection with influenza A virus. The cytotoxic activity of FR191512 against MDCK cells was very weak.
Nishihara
Y
Y
Fermentation Development Laboratories, Fujisawa Pharmaceutical Co, Ltd, Nishikasugai-gun, Aichi, Japan.
Tsujii
E
E
Yamagishi
Y
Y
Kino
T
T
Hino
M
M
Yamashita
M
M
Hashimoto
S
S
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D004195:Disease Models, Animal; D004285:Dogs; D005658:Fungi / Q000737:chemistry*; D009980:Influenza A virus / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D011091:Polyesters / Q000302:isolation & purification* / Q000494:pharmacology; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology
D000998:Antiviral Agents; C421166:FR 191512; D011091:Polyesters; D012118:Resorcinols