[Effect of the mycotoxin zearalenone on the metabolism of membrane phospholipids of rat lymphocytes].
The data obtained have shown that a single intravenous administration of 1 ml of mycotoxin zearalenon alcohol solution (15 mg/ml) to rats leads to the formation of pronounced abnormalities in lymphocyte membranes phospholipid (PL) metabolism. These changes are conditioned by activation of phospholipase A2, which catalyses the deacylation of PL-glycerides predominantly phosphatidylcholines with the formation of high concentrations of lysophosphatidylcholines. On the other hand, intensification of deacylation processes of PL, which accompanied by the liberation of high quantities of unsaturated fatty acids leads to the active incorporation of its into the processes of lipids free radical peroxidation with the formation of significant quantities of lipid peroxides. Intraperitoneal administration of 1 ml 10% sol of sodium thiosulfate no later then 1-2 h after zearalenon toxic action leads to the normalization of disorders observed.
Karagezian
M K
MK
Institute of Molecular Biology of Armenia Republic NAS.Konstant@mb.sci.am
D000818:Animals; D008214:Lymphocytes / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D015025:Zearalenone / Q000494:pharmacology*
D008563:Membrane Lipids; D010743:Phospholipids; D015025:Zearalenone
Vliianie mikotoksina zearalenona na metabolim fosfolipidov membran limfotsitov krys.