Antiproliferative effects of small fruit juices on several cancer cell lines.
Juices prepared from small fruits, mainly growing in the northern part of Japan, were studied in an attempt to explore the feasibility of an assay that screens cytotoxic properties. Screening of 43 small fruit juices indicated that Actinidia polygama Maxim., Rosa rugosa Thunb., Vaccinium smallii A. Gray and Sorbus sambucifolia Roem, strongly inhibited the proliferation of all cancer cell lines examined and yet these juices were substantially less cytotoxic toward normal human cell lines.
Yoshizawa
Y
Y
Laboratory of Bio-organic Chemistry, Akita Prefectural University, Akita, Japan. yyoshizawak@akita-pu.ac.jp
Kawaii
S
S
Urashima
M
M
Fukase
T
T
Sato
T
T
Tanaka
R
R
Murofushi
N
N
Nishimura
H
H
D001628:Beverages; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor / Q000379:methods*; D005240:Feasibility Studies; D005638:Fruit; D006801:Humans; D014407:Tumor Cells, Cultured / Q000187:drug effects