CD2-associated protein and the kidney.
During the past 3 years there have been significant advances in our understanding of the biology of the glomerular podocyte. In particular, two proteins, CD2-associated protein and nephrin, have been identified as critical podocyte proteins that are both required for normal glomerular filtration. In addition to supporting the idea that the slit diaphragm plays a crucial role in glomerular function, these results suggest novel insights into the pathogenesis of glomerular diseases. The present review addresses these recent advances and discusses the implications of the findings.
Shaw
A S
AS
Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA. andrey@pathbox.wustl.edu
Miner
J H
JH
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D003598:Cytoskeletal Proteins; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007674:Kidney Diseases / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D051437:Renal Insufficiency / Q000235:genetics / Q000401:mortality
D048868:Adaptor Proteins, Signal Transducing; C114545:CD2-associated protein; D003598:Cytoskeletal Proteins; D011506:Proteins