title: Resistance of t(11;18) positive gastric mucosa-associated lymphoid tissue lymphoma to Helicobacter pylori eradication therapy.
abstract: 20-30% of gastric mucosa-associated lymphoid tissue (MALT) lymphoma associated with Helicobacter pylori do not regress after antibiotic therapy. Regression can be assessed only by extended follow-up. To assess whether t(11;18, q21;q21), which results in a chimeric transcript between the AP12 and MLT genes, predicts lymphoma resistance to antibiotic therapy, we screened for the fusion transcript with RT-PCR in ten responsive and 12 non-responsive gastric MALT lymphomas. The AP12-MLT transcript was detected in nine (75%) of 12 patients non-responsive to antibiotic therapy but not in responsive patients. Most H pylori-associated gastric MALT lymphomas that do not respond to antibiotic therapy are associated with t(11;18, q21;q21).
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: A
authors.initials: A
authors.lastname: Ruskon-Fourmestraux
authors.forename: A
authors.initials: A
authors.lastname: Lavergne-Slove
authors.forename: H
authors.initials: H
authors.lastname: Ye
authors.forename: T
authors.initials: T
authors.lastname: Molina
authors.forename: Y
authors.initials: Y
authors.lastname: Bouhnik
authors.forename: R A
authors.initials: RA
authors.lastname: Hamoudi
authors.forename: T C
authors.initials: TC
authors.lastname: Diss
authors.forename: A
authors.initials: A
authors.lastname: Dogan
authors.forename: F
authors.initials: F
authors.lastname: Megraud
authors.forename: J C
authors.initials: JC
authors.lastname: Rambaud
authors.forename: M Q
authors.initials: MQ
authors.lastname: Du
authors.forename: P G
authors.initials: PG
authors.lastname: Isaacson
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D019008:Drug Resistance, Neoplasm; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000188:drug therapy / Q000235:genetics* / Q000382:microbiology; D008297:Male; D008875:Middle Aged; D015514:Oncogene Proteins, Fusion / Q000235:genetics; D012334:RNA, Neoplasm / Q000235:genetics / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000382:microbiology; D014178:Translocation, Genetic
chemical_list: C415943:API2-MALT1 fusion protein, human; D000900:Anti-Bacterial Agents; D015514:Oncogene Proteins, Fusion; D012334:RNA, Neoplasm