title: Testing the fetal origins hypothesis in twins: the Birmingham twin study.
abstract: OBJECTIVE
  To test whether the link between birthsize and raised blood pressure or glucose tolerance is due to genetic or intrauterine factors, we studied whether differences in birthweight between pairs of monozygous and dizygous twins are associated with adult differences in blood pressure and glucose tolerance.
  
  
  METHODS
  A sample of 58 monozygous and 140 dizygous twins were identified from a register of births in Birmingham, United Kingdom, between 1950 and 1954. The twins had their blood pressure measured and underwent an oral glucose tolerance test.
  
  
  RESULTS
  There were no statistically significant associations between birthweight, length or ponderal index, and either blood pressure or glucose tolerance in the twins. Although there were substantial within-pair differences in birthweight between monozygous and dizygous twin pairs, these differences did not correlate with the adult outcomes. Monozygous correlations, however, for both blood pressure and glucose tolerance were statistically significantly higher than dizygous correlations and a quantitative genetic model suggested statistically significant heritability for these traits. In contrast correlations of birthsize were similar in monozygous and dizygous pairs suggesting only a small genetic component in determining fetal size.
  
  
  CONCLUSIONS
  Our results show that birthsize in twins does not predict adult blood pressure or glucose tolerance. We also suggest that shared genetic determinants for fetal growth and adult outcomes are not likely to be prevalent or powerful.
authors.affiliation: MRC Environmental Epidemiology Unit, Southampton General Hospital, UK.
authors.forename: J
authors.initials: J
authors.lastname: Baird
authors.forename: C
authors.initials: C
authors.lastname: Osmond
authors.forename: A
authors.initials: A
authors.lastname: MacGregor
authors.forename: H
authors.initials: H
authors.lastname: Snieder
authors.forename: C N
authors.initials: CN
authors.lastname: Hales
authors.forename: D I
authors.initials: DI
authors.lastname: Phillips
mesh_terms: D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000235:genetics; D001824:Body Constitution; D015992:Body Mass Index; D005215:Fasting; D005865:Gestational Age; D018149:Glucose Intolerance / Q000235:genetics; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
chemical_list: D001786:Blood Glucose; D007328:Insulin