title: Studies directed towards the refinement of the pancratistatin cytotoxic pharmacophore.
abstract: Two deoxy-analogues of the anticancer/antiviral agent pancratistatin containing functionality complementary to the minimum structural pharmacophore were synthesized and subjected to anticancer screening. One of the analogues exhibited selective inhibition of certain tumor cell lines but was significantly less potent than the natural products. The minimum structural pharmacophore has now been refined from eight to three possible structures.
authors.affiliation: Institute of Molecular Catalysis, Department of Chemistry, Brock University, St. Catharines, Ontario, Canada. jmcnulty@chemiris.labs.brocku.ca
authors.forename: J
authors.initials: J
authors.lastname: McNulty
authors.forename: J
authors.initials: J
authors.lastname: Mao
authors.forename: R
authors.initials: R
authors.lastname: Gibe
authors.forename: R
authors.initials: R
authors.lastname: Mo
authors.forename: S
authors.initials: S
authors.lastname: Wolf
authors.forename: G R
authors.initials: GR
authors.lastname: Pettit
authors.forename: D L
authors.initials: DL
authors.lastname: Herald
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D047151:Amaryllidaceae Alkaloids; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D020128:Inhibitory Concentration 50; D007546:Isoquinolines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D051379:Mice; D008958:Models, Molecular; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D047151:Amaryllidaceae Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007546:Isoquinolines; C044997:pancratistatin