title: Use of an asbestos exposure score and the presence of pleural and parenchymal abnormalities in a lung cancer case series.
abstract: To assess whether there was an association between asbestos exposure and abnormalities on chest x-rays or CT scans, chest radiographs and CT scans of 103 asbestos-exposed patients with known lung cancer were reviewed for pleural or parenchymal abnormalities. Asbestos exposure was assessed using an asbestos exposure index that integrated time and intensity of reported exposure via a weighting scheme. Chest CT scans were clearly more sensitive in detecting pleural or parenchymal abnormalities than were standard PA chest x-rays. Furthermore, there was a significant correlation between higher asbestos exposure index scores and abnormalities on CT scans. Multivariable logistic regression models were used to investigate the relationship between the asbestos exposure index score and pleural or parenchymal abnormalities after adjusting for gender, pack-years of smoking, and cell type. None of these variables was associated with abnormalities on chest x-rays or CT scans. An asbestos exposure score > 10 was associated with pleural or parenchymal abnormalities (OR = 4.93; 95%CI 1.05-23.12). The results suggest that assessment of asbestos exposures by means of an algorithm-based index can classify the exposures accurately for epidemiologic studies.
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts 02115, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Schaeffner
authors.forename: D P
authors.initials: DP
authors.lastname: Miller
authors.forename: J C
authors.initials: JC
authors.lastname: Wain
authors.forename: D C
authors.initials: DC
authors.lastname: Christiani
mesh_terms: D000293:Adolescent; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D001194:Asbestos / Q000009:adverse effects*; D001195:Asbestosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D016015:Logistic Models; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D010995:Pleural Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D011446:Prospective Studies; D013902:Radiography, Thoracic; D015203:Reproducibility of Results; D012907:Smoking / Q000009:adverse effects; D014057:Tomography, X-Ray Computed
chemical_list: D001194:Asbestos