Effects of nutrients and serotonin 5-HT3 antagonism on symptoms evoked by distal gastric distension in humans.
Distal gastric distension may contribute to meal-related dyspeptic symptoms. This study's aims were to determine the effects of distinct nutrient classes on symptoms induced by distal gastric distension and their dependence on 5-hydroxytryptamine(3) (5-HT3) receptors. Nine healthy subjects rated pain, nausea, and bloating induced by isobaric distal gastric distensions (6-24 mmHg) during duodenal lipid, carbohydrate, protein, or saline perfusion after treatment with placebo or the 5-HT3 receptor antagonist granisetron (10 microg/kg iv). Distensions produced greater pain, nausea, and bloating with lipid at 1.5 kcal/min compared with saline (P < or = 0.02), primarily because of greater distal gastric volumes at each distending pressure. In contrast, carbohydrate and protein had no significant effect. At 3 kcal/min, lipid increased symptoms through a volume-independent as well as a volume-dependent effect. Granisetron did not affect symptom perception or gastric pressure-volume relationships. In conclusion, isobaric distal gastric distension produces more intense symptoms during duodenal lipid compared with saline perfusion. Symptom perception during distal gastric distension is unaffected by 5-HT3 receptor antagonism.
Ladabaum
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Division of Gastroenterology, Department of Internal Medicine, School of Public Health, University of Michigan, Ann Arbor, Michigan 48109-0362, USA. ladabau@itsa.ucsf.edu
Brown
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Pan
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Owyang
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Hasler
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D000328:Adult; D002241:Carbohydrates / Q000008:administration & dosage; D002404:Catheterization; D004311:Double-Blind Method; D004386:Duodenum / Q000502:physiology; D005260:Female; D017829:Granisetron / Q000494:pharmacology*; D006801:Humans; D007441:Intubation, Gastrointestinal; D008055:Lipids / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000209:etiology; D009747:Nutritional Physiological Phenomena; D010146:Pain / Q000209:etiology; D011312:Pressure; D011506:Proteins / Q000008:administration & dosage; D011985:Receptors, Serotonin / Q000187:drug effects*; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013270:Stomach / Q000502:physiology*
D002241:Carbohydrates; D017829:Granisetron; D008055:Lipids; D011506:Proteins; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists