Clozapine, but not haloperidol, reverses social behavior deficit in mice during withdrawal from chronic phencyclidine treatment.
Phencyclidine (PCP) reduced social behavior (SB) in a dose- and time-dependent fashion. However, no such SB deficit was observed on repeated treatment with methamphetamine for 14 days. The SB deficit produced by treatment with PCP (10 mg/kg/day) for 14 days, which persisted for 28 days after withdrawal, was attenuated by clozapine (10 mg/kg/day) given for 7 days, whereas haloperidol for 7 days had no effect. Clozapine, but not haloperidol, alone at the same treatment dose increased SB in saline-treated mice. These results suggest that the proposed PCP model in mice will provide a tool to test beneficial effects of atypical antipsychotics on social dysfunction in schizophrenia, and contribute to our understanding of the mechanisms by which clozapine improves SB deficit.
Qiao
H
H
Department of Psychiatry, Nagoya University Graduate School of Medicine, Meijo University, Japan.
Noda
Y
Y
Kamei
H
H
Nagai
T
T
Furukawa
H
H
Miura
H
H
Kayukawa
Y
Y
Ohta
T
T
Nabeshima
T
T
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D003024:Clozapine / Q000494:pharmacology* / Q000627:therapeutic use; D006213:Hallucinogens / Q000009:adverse effects*; D006220:Haloperidol / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D023421:Models, Animal; D010622:Phencyclidine / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy; D012919:Social Behavior; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000523:psychology*
D014150:Antipsychotic Agents; D006213:Hallucinogens; D010622:Phencyclidine; D003024:Clozapine; D006220:Haloperidol