title: Limbic encephalitis investigated by 18FDG-PET and 3D MRI.
abstract: Two patients with clinically probable or possible limbic encephalitis (LE) are reported, both cases with typical findings in clinical symptoms (severe neuropsychological deficits and complex partial seizures) and in routine magnetic resonance imaging (MRI) (hyperintense mesiotemporal lesions). Underlying malignancy was identified (rectal carcinoma) in one case but could not be detected in the other patient. The 2 patients were investigated by cerebral 18F-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) and 3-dimensional (3D) MRI, and abnormalities in metabolic activity were mapped using coregistration of spatially normalized PET and MRI. Highly significant focal hypermetabolism in bilateral hippocampal areas was found in both cases. The authors' findings support FDG-PET coregistered to 3D MRI as a potentially valuable additional tool in the imaging diagnostics of LE. Results are discussed with respect to the clinical symptoms and previously reported imaging findings in the disease.
authors.affiliation: Department of Neurology, University of Freiburg, Breisacher Str. 64, 79106 Freiburg, Germany. kassubek@nz.ukl.uni-freiburg.de
authors.forename: J
authors.initials: J
authors.lastname: Kassubek
authors.forename: F D
authors.initials: FD
authors.lastname: Juengling
authors.forename: E U
authors.initials: EU
authors.lastname: Nitzsche
authors.forename: C H
authors.initials: CH
authors.lastname: Lücking
mesh_terms: D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D019788:Fluorodeoxyglucose F18; D006801:Humans; D020363:Limbic Encephalitis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18