[Glucagon-like peptide 2, a neurotransmitter with a newly discovered role in the regulation of food ingestion].
We report here that glucagon-like peptide 2(GLP-2) and its receptor constitute a distinct projection system connecting the nucleus of the solitary tract with the dorsomedial hypothalamic nucleus (DMH). The DMH contains a dense plexus of GLP-2 immunoreactive fibres and is the only hypothalamic nucleus expressing GLP-2 receptor mRNA. Consistent with this, central application of GLP-2 activates the expression of neurones solely in the DMH. Furthermore, central administration of GLP-2 causes a dose-related, a pharmacologically and behaviourally specific inhibition of food intake in rats. Surprisingly, the alleged GLP-1 receptor antagonist, Exending (9-39), proved a functional antagonist of centrally applied GLP-2. These data implicate GLP-2 as an important neurotransmitter in the regulation of food intake and likely bodyweight. Our data therefore point to the DMH as a crossroad for endocrine and visceral information affecting feeding behaviour.
Tang-Christensen
M
M
Københavns Universitet, Medicinsk Anatomisk Institut B, Panum Instituttet, CCBR, Laboratory for Obesity Research, Ballerup.
Larsen
P J
PJ
Thulesen
J
J
Nielsen
J R
JR
Vrang
N
N
D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology*; D001933:Brain Stem / Q000276:immunology / Q000378:metabolism; D004302:Dorsomedial Hypothalamic Nucleus / Q000276:immunology / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000008:administration & dosage / Q000276:immunology / Q000502:physiology*; D015870:Gene Expression; D052216:Glucagon-Like Peptide 1; D053767:Glucagon-Like Peptide 2; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D018377:Neurotransmitter Agents / Q000008:administration & dosage / Q000276:immunology / Q000502:physiology*; D010455:Peptides / Q000008:administration & dosage / Q000276:immunology / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017208:Rats, Wistar; D018027:Receptors, Glucagon / Q000235:genetics / Q000276:immunology / Q000502:physiology*
D005768:Gastrointestinal Hormones; D053767:Glucagon-Like Peptide 2; D018377:Neurotransmitter Agents; D010455:Peptides; D012333:RNA, Messenger; D018027:Receptors, Glucagon; D052216:Glucagon-Like Peptide 1
Glucagonlignende peptid-2, en neurotransmitter med en nyopdaget rolle i reguleringen af fødeindtagelsen.