The shifting patterns of metastatic melanoma.
Management of cutaneous melanoma becomes more difficult as tumor cells metastasize to sites that are remote from the primary tumor. There is a hierarchy of risk associated with cancer spread by different routes and to different organs. Differences in clinical outcome indicate critical variations in pathobiology at different stages in disease evolution. Prevention of the evolution of melanoma is critical, especially beyond the stage of nodal involvement.
Cochran
A J
AJ
Departments of Pathology and Laboratory Medicine and Surgery, UCLA School of Medicine, Los Angeles, California, USA. acochran@mednet.ucla.edu
Bhuta
S
S
Paul
E
E
Ribas
A
A
D001707:Biopsy, Needle; D006801:Humans; D008197:Lymph Node Excision; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000556:secondary*; D009508:Nevus, Pigmented / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000473:pathology*