[Significance of lacrimal fluid peroxidation and anti-radical defense parameters for prediction and treatment of complicated myopia].
Study of lipid peroxidation and antiradical defense parameters in the lacrimal fluid from 270 eyes of children and adolescents with progressive myopia demonstrated a relationship between the development of peripheral vitreochorioretinal dystrophies and imbalance between antioxidant activity (AOA) of lacrimal fluid and intensity of radical formation evaluated by chemiluminescence (CL) intensity. The AOA/CL ratio is proposed as a reliable indicator for predicting the course of progressive myopia. A value < 30 indicates poor level of antioxidant defense of ocular media and tissues and is a prognostically unfavorable sign as regards development of peripheral vitreochorioretinal dystrophy. A local antioxidant remedy has been developed and clinically tried for preventing and treating complicated myopia: ocular medicinal films with emoxipin and pyridoxine hydrochloride.
Vinetskaia
M I
MI
Iomdina
E N
EN
Tarutta
E P
EP
Kushnarevich
N Iu
NIu
Lazuk
A V
AV
D000293:Adolescent; D000975:Antioxidants / Q000627:therapeutic use*; D015415:Biomarkers; D002648:Child; D018450:Disease Progression; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D009216:Myopia / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D011379:Prognosis; D013666:Tears / Q000378:metabolism*; D018630:Vitreoretinopathy, Proliferative / Q000175:diagnosis / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*
D000975:Antioxidants; D015415:Biomarkers; D016166:Free Radical Scavengers
Znachenie pokazateleĭ perekisnogo okisleniia lipidov i antiradikal'noĭ zashchity sleznoĭ zhidkosti dlia prognozirovaniia i lecheniia oslozhnennoĭ blizorukosti.