title: Origin of enzootic intranasal tumor in the goat (Capra hircus): a glycohistochemical approach.
abstract: Enzootic intranasal tumor (EIT) appears glandular in type and has recently been classified as an adenocarcinoma of low malignancy. The aim of this study was to characterize the secretion of surface glycoconjugates (GCs) in EIT and in normal respiratory and olfactory mucosae of the goat by means of conventional and lectin histochemistry, in order to shed light on the histogenesis of EIT. Morphologic and ultrastructural investigations showed two growth types of EIT: i.e., tubular and papillary patterns. Conventional histochemistry revealed the presence of neutral and carboxylated GCs in the olfactory glands and in the tubular part of EIT, as well neutral and sulphated GCs in the respiratory glands and in the papillary part of EIT, suggesting that the papillary pattern tumor arises from the respiratory glands, whereas the tubular portion of EIT arises from the olfactory glands. Lectin histochemistry gave further information on the expressed GCs.
authors.affiliation: Dipartimento di Scienze Veterinarie, Facoltà di Medicina Veterinaria, Università di Camerino, Italia.
authors.forename: P
authors.initials: P
authors.lastname: Scocco
authors.forename: F
authors.initials: F
authors.lastname: Mariotti
authors.forename: P
authors.initials: P
authors.lastname: Ceccarelli
authors.forename: O
authors.initials: O
authors.lastname: Fagioli
authors.forename: G
authors.initials: G
authors.lastname: Renzoni
authors.forename: G
authors.initials: G
authors.lastname: Vitellozzi
mesh_terms: D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D006001:Glycoconjugates / Q000378:metabolism*; D015511:Goat Diseases / Q000473:pathology* / Q000503:physiopathology; D006041:Goats; D006651:Histocytochemistry; D037102:Lectins / Q000737:chemistry; D009669:Nose Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D009831:Olfactory Mucosa / Q000378:metabolism / Q000473:pathology*
chemical_list: D006001:Glycoconjugates; D037102:Lectins