title: Effects of bupropion sustained-release on sexual functioning and nocturnal erections in healthy men.
abstract: Many antidepressants are known to cause adverse sexual effects. Bupropion is an antidepressant with fewer reported adverse sexual effects. Studies of sexual side effects are often confounded by psychiatric and medical conditions affecting sexual function. In this study, the effects of bupropion on subjective and objective sexual functioning were measured in healthy men. Thirteen men without psychiatric or medical illness completed a 2-week, placebo-controlled, double-blind, crossover trial of bupropion sustained-release 300 mg/day. Subjects had a 1-week washout period between trials. Sexual function was measured using a validated, self-administered questionnaire and the RigiScan, an instrument measuring nocturnal penile tumescence and rigidity. No differences were found in self-reported sexual function, number of erections, total erection time, or penile rigidity in subjects taking bupropion compared with those taking placebo or baseline. These findings support that bupropion does not have subjective adverse sexual side effects and does not affect nocturnal erections in healthy men.
authors.affiliation: Department of Psychiatry and Behavioral Science, Medical University of South Carolina, and VA Medical Center, Charleston 29401, USA. labbatel@musc.edu
authors.forename: L A
authors.initials: LA
authors.lastname: Labbate
authors.forename: P S
authors.initials: PS
authors.lastname: Brodrick
authors.forename: R P
authors.initials: RP
authors.lastname: Nelson
authors.forename: R B
authors.initials: RB
authors.lastname: Lydiard
authors.forename: G W
authors.initials: GW
authors.lastname: Arana
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects / Q000494:pharmacology*; D016642:Bupropion / Q000009:adverse effects / Q000494:pharmacology*; D018592:Cross-Over Studies; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000187:drug effects*; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced*
chemical_list: D018687:Antidepressive Agents, Second-Generation; D003692:Delayed-Action Preparations; D016642:Bupropion