title: Population genetics of the hypervariable locus D12S391 in Koreans.
abstract: The hypervariable short tandem repeat (STR) locus D12S391 was investigated in a Korean population and 34 fragments were sequenced to confirm the structure of alleles. From these sequenced fragments an allelic ladder containing 13 sequenced alleles was constructed. From 595 unrelated Koreans, 14 alleles were detected and one variant allele 19.3 was observed. The observed heterozygosity was 0.795 and no deviation from Hardy-Weinberg equilibrium was observed in the Korean population (p = 0.606). The allele frequency distribution in the Korean population was not similar to other racial or ethnic groups except for Egyptians, Yemenis, Japanese and Caucasoids from the Rhine area. No mutations were observed in the 702 meioses from 144 Korean families. This study demonstrates that the STR locus D12S391 is a useful tool for forensic identification and parentage testing.
authors.affiliation: Department of Legal Medicine, College of Medicine, Korea University, 126-1.5Ga, Anam-Dong, Sungbuk-Ku, Seoul 136-705, Korea.
authors.forename: Y W
authors.initials: YW
authors.lastname: Lee
authors.forename: I H
authors.initials: IH
authors.lastname: Kang
authors.forename: S M
authors.initials: SM
authors.lastname: Kim
authors.forename: H L
authors.initials: HL
authors.lastname: Lee
authors.forename: T W
authors.initials: TW
authors.lastname: Koo
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
authors.forename: J J
authors.initials: JJ
authors.lastname: Hwang
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D016172:DNA Fingerprinting; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D010334:Paternity; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences / Q000235:genetics*