Synergistic effect of enhancers for transdermal drug delivery.
Transdermal drug delivery offers a non-invasive route of drug administration, although its applications are limited by low skin permeability. Various enhancers including iontophoresis, chemicals, ultrasound, and electroporation have been shown to enhance transdermal drug transport. Although all these methods have been individually shown to enhance transdermal drug transport, their combinations have often been found to enhance transdermal transport more effectively than each of them alone. This paper summarizes literature studies on these combinations with respect to their efficacy and mechanisms.
Mitragotri
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Department of Chemical Engineering, University of California, Santa Barbara 93106, USA. samir@engineering.ucsb.edu
D000277:Adjuvants, Pharmaceutic / Q000494:pharmacology; D000279:Administration, Cutaneous; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D018274:Electroporation; D006801:Humans; D007478:Iontophoresis; D012869:Skin Absorption / Q000187:drug effects / Q000502:physiology; D014465:Ultrasonics
D000277:Adjuvants, Pharmaceutic