Physiological regulation of uteroglobin/CCSP expression.
Uteroglobin/CCSP is expressed specifically in the Clara cells. This allows the gene to be used as a marker to identify the elements regulating the physiologic and cell-specific expression of this gene. The regulation of UG/CCSP by IFN-gamma was shown to be at the level of the proximal promoter by the upregulation of HNF3 beta. This has allowed the determination of the factors responsible for the expression of UG/CCSP.
Chang
A
A
Department of Surgery, Baylor College of Medicine, 1 Baylor Plaza, M725, Houston, TX 77030, USA.
Ramsay
P
P
Zhao
B
B
Park
M
M
Magdaleno
S
S
Reardon
M J
MJ
Welty
S
S
DeMayo
F J
FJ
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D051379:Mice; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D020545:Respiratory Mucosa / Q000166:cytology / Q000378:metabolism*; D014598:Uteroglobin / Q000235:genetics* / Q000378:metabolism
D011506:Proteins; C556389:SCGB1A1 protein, human; C556390:Scgb1a1 protein, mouse; D014598:Uteroglobin