title: A polymorphic microsatellite marker in the human p55 TNF receptor, CD120a.
abstract: We provide characterization of a highly polymorphic dinucleotide repeat in the human TNF-receptor 1 gene (TNFR1, TNFRp55, CD120a). We have observed 11 alleles at this locus in individuals from the West of Scotland. In a panel of healthy, unrelated individuals from the West of Scotland (n = 143), the overall heterozygosity was 68%, indicating the potential usefulness of these markers in immunogenetic studies.
authors.affiliation: University of Glasgow Department of Surgery, Queen Elizabeth Building, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland.
authors.forename: J
authors.initials: J
authors.lastname: Eskdale
authors.forename: R L
authors.initials: RL
authors.lastname: Turestkaya
authors.forename: C
authors.initials: C
authors.lastname: Armstrong
authors.forename: D V
authors.initials: DV
authors.lastname: Kuprash
authors.forename: S A
authors.initials: SA
authors.lastname: Nedospasov
authors.forename: G
authors.initials: G
authors.lastname: Gallagher
mesh_terms: D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D018900:Dinucleotide Repeats; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*; D047888:Receptors, Tumor Necrosis Factor, Type I; D012606:Scotland
chemical_list: D015703:Antigens, CD; D017931:DNA Primers; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D004247:DNA