title: Genetic regulation of embryo death and senescence.
abstract: The survival of the preimplantation mammalian embryo depends not only on providing the proper conditions for normal development but also on acquiring the mechanisms by which embryos cope with adversity. The ability of the early conceptus to resist stress as development proceeds may be regulated by diverse factors such as the attainment of a cell death program and protective mechanisms involving stress-induced genes and/or cell cycle modulators. This paper reviews the recent research on the genetic regulation of early embryo cell death and senescence focussing on the bovine species where possible. The different modes of cell death will be explained, clarifying the confusing cell death terminology, by advocating the recommendations set forth by the Cell Death Nomenclature Committee to extend to the embryology research field. Specific pro-death and anti-death genes will be discussed with reference to their expression patterns during early mammalian embryogenesis.
authors.affiliation: Department of Biomedical Sciences, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada, N1G 2WI. bettsd@uoguelph.ca
authors.forename: D H
authors.initials: DH
authors.lastname: Betts
authors.forename: W A
authors.initials: WA
authors.lastname: King
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics; D002417:Cattle; D016922:Cellular Senescence / Q000235:genetics; D046508:Culture Techniques; D005313:Fetal Death / Q000235:genetics*; D005865:Gestational Age; D006801:Humans; D009336:Necrosis