Bioactive oleanolic acid saponins and other constituents from the roots of Viguiera decurrens.
The bisdesmoside oleanolic acid saponin, 3-0-(methyl-beta-D-glucuronopyranosiduronoate)-28-0-beta-D-glucopyranosyl-oleanolate along with nine known compounds (two diterpenic acids, one chromene, three triterpenes, one steroidal glycoside, and two monodesmoside oleanolic acid saponins), were obtained from Viguiera decurrens roots. The chemical structure of the bisdesmoside oleanolic saponin was determined by chemical and NMR spectral evidence. A mixture of monodesmoside saponins displayed cytotoxic activity against P388 and COLON cell lines (ED50= 2.3 and 3.6 microg/ml, respectively). Two of the known compounds showed insecticidal activity against the Mexican bean beetle larvae (Epilachna varivestis).
Marquina
S
S
Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico.
Maldonado
N
N
Garduño-Ramírez
M L
ML
Aranda
E
E
Villarreal
M L
ML
Navarro
V
V
Bye
R
R
Delgado
G
G
Alvarez
L
L
D019659:Asteraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000737:chemistry* / Q000031:analogs & derivatives; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
C422662:3-O-(methyl glucuronopyranosiduronoate)-28-O-glucopyranosyl-oleanolate; D012503:Saponins; D009828:Oleanolic Acid