[The role of endogenous glucocorticoids in maintenance of the gastric mucosa integrity].
Effect of glucocorticoid deficiency on susceptibility to gastric mucosal injury by non-steroid anti-inflammatory drugs (NSAID) was studied in rats. The corticosterone production was inhibited by a single large dose of cortisol as well as by an adrenalectomy. The drop in the corticosterone production prompted gastric erosions induced by the NSAID. Replacing corticosterone prevented the effects of cortisol pretreatment of adrenalectomy on NSAID-induced gastric erosions. The data obtained reveal a gastroprotective effect of endogenous glucocorticoids.
Filaretova
L P
LP
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Bagaeva
T P
TP
D000315:Adrenalectomy; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin; D003345:Corticosterone / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology*; D005938:Glucocorticoids / Q000096:biosynthesis* / Q000097:blood / Q000494:pharmacology; D006727:Hormone Antagonists / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007213:Indomethacin; D008297:Male; D015735:Mifepristone / Q000494:pharmacology; D010438:Peptic Ulcer Hemorrhage / Q000139:chemically induced / Q000473:pathology* / Q000517:prevention & control; D010913:Pituitary-Adrenal System / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005938:Glucocorticoids; D006727:Hormone Antagonists; D015735:Mifepristone; D001241:Aspirin; D003345:Corticosterone; D006854:Hydrocortisone; D007213:Indomethacin
Rol' éndogennykh gliukokortikoidov v podderzhanii tselostnosti slizistoĭ obolochki zheludka.