title: [Pathology of paraneoplastic syndromes of the central and peripheral nervous systems and muscle ].
abstract: The paraneoplastic neurological syndromes are alterations associated with neoplasias. However, they are not caused by metastases or complications such as infections, vascular disorders, metabolic or nutritional alterations or secondary effect of treatment. The paraneoplastic syndromes are often associated with the creation of autoantibodies against antigens produced by the neoplastia, but also may be against other cells or target molecules of the patient. Sometimes, especially with antibodies directed against cell membrane proteins, there is a close relationship between the antibody and the target organ, as for example antibodies against the acetylcholine receptor in myasthenia gravis. On other occasions, especially when the antigen is intracellular, the mechanism of the autoantibody reaction is not known. Finally, in a third group, the antibody associated with a particular paraneoplastic neurological alteration has not been identified. In this paper we describe the main paraneoplastic neurological pictures and known antibodies, including the molecular aspects and the neoplasias most frequently related to them.
authors.affiliation: Servicio de Anatomía Patológica, Hospital Prínceps d'Espanya, Departamento de Biología Celular y Anatomía Patológica, Universidad de Barcelona, Campus de Bellvitge, Hospitalet de Llobregat, Banco de Tejidos Neurológicos, Barcelona, España. iferrer@sakma.es
authors.forename: I
authors.initials: I
authors.lastname: Ferrer
mesh_terms: D000328:Adult; D000912:Antibodies, Neoplasm / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001921:Brain / Q000473:pathology; D002648:Child; D020278:Demyelinating Autoimmune Diseases, CNS / Q000209:etiology / Q000276:immunology / Q000473:pathology; D003882:Dermatomyositis / Q000209:etiology / Q000276:immunology / Q000473:pathology; D020275:Guillain-Barre Syndrome / Q000209:etiology / Q000276:immunology / Q000473:pathology; D006801:Humans; D015624:Lambert-Eaton Myasthenic Syndrome / Q000209:etiology / Q000276:immunology / Q000473:pathology; D020363:Limbic Encephalitis / Q000209:etiology / Q000276:immunology / Q000473:pathology; D016472:Motor Neuron Disease / Q000209:etiology / Q000276:immunology / Q000473:pathology; D009135:Muscular Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D009157:Myasthenia Gravis / Q000209:etiology / Q000276:immunology / Q000473:pathology; D009363:Neoplasm Proteins / Q000276:immunology; D009469:Neuromuscular Junction / Q000276:immunology / Q000473:pathology; D009474:Neurons / Q000276:immunology / Q000473:pathology; D020362:Paraneoplastic Cerebellar Degeneration / Q000209:etiology / Q000276:immunology / Q000473:pathology; D020361:Paraneoplastic Syndromes, Nervous System / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D010525:Peripheral Nerves / Q000473:pathology; D011129:Polyradiculoneuropathy / Q000209:etiology / Q000276:immunology / Q000473:pathology; D015221:Potassium Channels / Q000276:immunology; D011689:Purkinje Cells / Q000276:immunology / Q000473:pathology; D012160:Retina / Q000473:pathology; D012164:Retinal Diseases / Q000209:etiology / Q000276:immunology / Q000473:pathology; D016750:Stiff-Person Syndrome / Q000209:etiology / Q000276:immunology / Q000473:pathology
chemical_list: D000912:Antibodies, Neoplasm; D001323:Autoantibodies; D001324:Autoantigens; D009363:Neoplasm Proteins; D015221:Potassium Channels
vernacular_title: Patología de los síndromes paraneoplásicos del sistema nervioso central, periférico y músculo.