[Clinical effect and tolerance of paxil (paroxetine) in management of panic disorders].
OBJECTIVE
To determine clinical efficiency and tolerance of paxil (paroxetin) in the treatment of panic disorders.


METHODS
An open, non-comparative 7 week study entered 60 patients (mean age 36.6 +/- 3.22 years) with panic disorders and agoraphobias with panic disorders. Paroxetin was given in a single daily dose 20-60 mg/day in the morning. The results were assessed by Hamilton and Sihan scales, scale of clinical impression, by reduction of panic attacks.


RESULTS
In 72.2% of patients panic attacks ceased or occurred less frequently (by 50%). Anxiety relieved by 67 +/- 4.6%. The number of the responders was greater while the effect occurred faster in patients with panic disorders. The drug was well tolerated, side effects occurred in 43.3% of cases. They were mild or moderate.


CONCLUSIONS
Paroxetin has a prominent anxiolytic and antiphobic action, is well tolerated and is effective in panic disorders and agoraphobia with panic disorders.
Mosolov
S N
SN
Smulevich
A B
AB
Nuller
Iu L
IuL
Grigor'evskikh
V S
VS
Kostiukova
E G
EG
Kuzavkova
M V
MV
Koliutskaia
E V
EV
Andriushchenko
A V
AV
Zelenina
E V
EV
Kosinskiĭ
V P
VP
Kozlovskiĭ
V L
VL
Bykov
S I
SI
Pererva
I G
IG
D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000188:drug therapy*; D017374:Paroxetine / Q000627:therapeutic use*; D016896:Treatment Outcome
D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine
Klinicheskaia éffektivnost' i perenosimost' paksila (paroksetina) pri lechenii panicheskogo rasstroĭstva.