[Gene therapy and tissue engineering in nephrology and renal transplantation].
Human genome project will be completed in 2003 and we will soon obtain the information of the whole DNA sequence of the human genome. This should affect the therapy of progressive renal diseases since we have no effective remedy to cure the renal diseases. Gene therapy, renal engineering and generation of new drug can be achieved by using the information of human genome. In this context, we described our recent endeavors concerning the gene therapy of transplant kidney, seeking the renal stem cells and reprogramming factors, and exploring genes related to renal fibrosis. Completion of bioinformatics, can facilitate the above post-genome project.
Imai
E
E
Department of Internal Medicine and Therapeutics, Osaka University Graduate School of Medicine.
Takenaka
M
M
Ito
T
T
Isaka
Y
Y
Moriyama
T
T
Hori
M
M
D000818:Animals; D001698:Biomedical Engineering; D001854:Bone Marrow Cells; D015195:Drug Design; D020869:Gene Expression Profiling; D015316:Genetic Therapy; D015894:Genome, Human; D023281:Genomics; D016045:Human Genome Project; D006801:Humans; D007668:Kidney / Q000502:physiology; D007674:Kidney Diseases / Q000235:genetics / Q000628:therapy*; D016030:Kidney Transplantation; D012038:Regeneration; D013234:Stem Cells