title: Progressive outer retinal necrosis in a patient with nephrotic syndrome.
abstract: Progressive outer retinal necrosis syndrome (PORN) is a variant of necrotizing herpetic retinopathy and the majority of the described cases were related to acquired immunodeficiency syndrome. We present a patient who is HIV negative with nephrotic syndrome and prednisolone use for 4 months who showed clinical features of PORN. Low CD4 counts and lymphocytopenia suggested immunosuppression. In the left eye, tractional retinal detachment at the posterior pole followed by incomplete posterior vitreous detachment developed. In addition to intravenous administration of acyclovir, vitreous surgeries including stripping of the posterior hyaloid and silicone-oil tamponade were successfully performed to repair the retinal detachment in the left eye and to prevent it in the right eye.
authors.affiliation: Department of Ophthalmology, Keio University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shinoda
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: S
authors.initials: S
authors.lastname: Ishida
authors.forename: S
authors.initials: S
authors.lastname: Kawashima
authors.forename: T
authors.initials: T
authors.lastname: Wakabayashi
authors.forename: S
authors.initials: S
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Katsura
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005938:Glucocorticoids / Q000627:therapeutic use; D018023:HIV Seronegativity; D006801:Humans; D008231:Lymphopenia / Q000150:complications; D009404:Nephrotic Syndrome / Q000150:complications* / Q000188:drug therapy; D011239:Prednisolone / Q000627:therapeutic use; D012163:Retinal Detachment / Q000209:etiology / Q000601:surgery; D015882:Retinal Necrosis Syndrome, Acute / Q000150:complications* / Q000473:pathology; D014794:Visual Fields; D014821:Vitrectomy; D020255:Vitreous Detachment / Q000209:etiology / Q000601:surgery
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone