title: Deletion of the gene encoding H-FABP/MDGI has no overt effects in the mammary gland.
abstract: Heart fatty acid binding protein (H-FABP) is expressed abundantly in the mammary gland. A number of in vitro studies have shown that H-FABP is functionally indistinguishable from a factor isolated from this organ, termed mammary derived growth inhibitor (MDGI), which specifically inhibits the proliferation of mammary tissue. We have previously shown that over-expression of H-FABP/MDGI in the mammary gland of transgenic mice has no discernable effects on cell proliferation or differentiation. In this report we describe knockout mouse in which the H-FABP/MDGI gene has been specifically disrupted. The mice exhibit no overt phenotype in the mammary gland, and we conclude that this gene does not play a specific role in regulating the normal development or function of this tissue.
authors.affiliation: Department of Gene Expression and Development, Roslin Institute, Midlothian, Scotland, UK. john.clark@bbsrc.ac.uk
authors.forename: A J
authors.initials: AJ
authors.lastname: Clark
authors.forename: C
authors.initials: C
authors.lastname: Neil
authors.forename: B
authors.initials: B
authors.lastname: Gusterson
authors.forename: J
authors.initials: J
authors.lastname: McWhir
authors.forename: B
authors.initials: B
authors.lastname: Binas
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D008321:Mammary Glands, Animal / Q000033:anatomy & histology / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D008892:Milk / Q000737:chemistry*; D008894:Milk Proteins / Q000032:analysis
chemical_list: D002352:Carrier Proteins; C493409:Fabp3 protein, mouse; D000074026:Fatty Acid Binding Protein 3; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D008894:Milk Proteins