title: Cytokine gene polymorphism in human disease: on-line databases.
abstract: The pathologies of many infectious, autoimmune and malignant diseases are influenced by the profiles of cytokine production in pro-inflammatory (TH1) and anti-inflammatory (TH2) T cells. Interindividual differences in cytokine profiles appear to be due, at least in part, to allelic polymorphism within regulatory regions of cytokine gene. Many studies have examined the relationship between cytokine gene polymorphism, cytokine gene expression in vitro, and the susceptibility to and clinical severity of diseases. A review of the findings of these studies is presented. An on-line version featuring appropriate updates is accessible from the World Wide Web site, http://www.pam.bris.ac.uk/services/GAI/cytokine4.htm.
authors.affiliation: Department of Pathology and Microbiology, University of Bristol, Homoeopathic Hospital Site, Cotham, Bristol BS6 6JU, UK.
authors.forename: J
authors.initials: J
authors.lastname: Bidwell
authors.forename: L
authors.initials: L
authors.lastname: Keen
authors.forename: G
authors.initials: G
authors.lastname: Gallagher
authors.forename: R
authors.initials: R
authors.lastname: Kimberly
authors.forename: T
authors.initials: T
authors.lastname: Huizinga
authors.forename: M F
authors.initials: MF
authors.lastname: McDermott
authors.forename: J
authors.initials: J
authors.lastname: Oksenberg
authors.forename: J
authors.initials: J
authors.lastname: McNicholl
authors.forename: F
authors.initials: F
authors.lastname: Pociot
authors.forename: C
authors.initials: C
authors.lastname: Hardt
authors.forename: S
authors.initials: S
authors.lastname: D'Alfonso
mesh_terms: D016207:Cytokines / Q000737:chemistry / Q000235:genetics*; D016208:Databases, Factual; D015870:Gene Expression; D006801:Humans; D066298:In Vitro Techniques; D020407:Internet; D011110:Polymorphism, Genetic; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines