[Influence of tumor drug resistance phenotype on the dynamics of cisplatin-induced changes of rat peripheral lymphocyte chromatin structure in Guerin's carcinoma].
The correlation between the tumor drug sensitivity and the degree of lymphocyte interphase nuclei chromatin damages induced by cisplatin in rats was found using sensitive and resistant to cisplatin variants of Guerin's carcinoma. Increased optical density of lymphocyte chromatin in first minutes after cisplatin injection both in rats without Guerin's carcinoma and with sensitive to cisplatin variants of this tumor was observed. Lymphocyte chromatin structure remains unchanged in rats with cisplatin resistant carcinoma. Normal blood cells are suppose to change their sensitiveness to cisplatin under the humoral influence of the growing tumor in according with its phenotype.
Chekhun
V F
VF
Ganina
K P
KP
Kulik
G I
GI
Solianik
G I
GI
Kunskaia
L N
LN
Gushchenko
N N
NN
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002277:Carcinoma / Q000188:drug therapy*; D002843:Chromatin / Q000737:chemistry / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology*; D019008:Drug Resistance, Neoplasm / Q000235:genetics*; D008214:Lymphocytes / Q000737:chemistry / Q000187:drug effects*; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D002843:Chromatin; D002945:Cisplatin
Vliianie fenotipa lekarstvennoi rezistentnosti opukholi na dinamiku indutsirovann'ikh tsisplatinom izmenenii struktur'i khromatina interfazn'ikh iader limfotsitov perifericheskoi krovi kr'is s kartsinomoi gerena.