[Driving ability after reversal of phenylephrine 10% induced mydriasis by dapiprazole 0.5%; a prospective study on 65 eyes].
BACKGROUND
Particularly outpatients want to reach the ability for driving a car as soon as possible after pupillary dilatation. Dapiprazole is an alpha-1 adrenergic inhibitor that antagonizes the mydriatic effect of phenylephrine in a direct competitive way. The aim of this study was to determine restoration of traffic related functions after dapiprazole application in accordance with the guidelines of the German Society of Ophthalmology (DOG).


METHODS
65 eyes of 33 subjects were tested (17 females, 16 males). All had driving licenses without restrictions. Before mydriasis and after reversal with dapiprazole traffic-related functions were evaluated (photopic visual acuity, mesopic vision, sensitivity to glare, colour vision, accommodation, visual field).


RESULTS
No relevant changes of the parameter responsible for the ability to drive a motor vehicle could be shown after reaching premydriatic pupil diameters.


CONCLUSIONS
There is evidence that reaching normal pupil diameters after reversal of mydriasis by dapiprazole is a valid sign of restoration of traffic related functions.
Schmidbauer
J M
JM
Augenklinik mit Poliklinik, Universitätskliniken des Saarlandes, Kirrbergerstrasse 1, 66421 Homburg, Saar.
Georg
T
T
Möller
M R
MR
Ruprecht
K W
KW
D000293:Adolescent; D000317:Adrenergic alpha-Antagonists / Q000627:therapeutic use*; D000328:Adult; D001334:Automobile Driving / Q000592:standards*; D018592:Cross-Over Studies; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D015878:Mydriasis / Q000139:chemically induced / Q000188:drug therapy*; D009184:Mydriatics / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D010656:Phenylephrine / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D010879:Piperazines; D011446:Prospective Studies; D011680:Pupil / Q000187:drug effects; D016896:Treatment Outcome; D014230:Triazoles / Q000627:therapeutic use*; D014785:Vision, Ocular / Q000187:drug effects*
D000317:Adrenergic alpha-Antagonists; D009184:Mydriatics; D010879:Piperazines; D014230:Triazoles; D010656:Phenylephrine; C035289:dapiprazole
Verkehrstauglichkeit nach Antagonisierung der Phenylephrin-10%-induzierten Mydriasis durch Dapiprazolhydrochlorid 0.5%--Prospektive Studie an 65 Augen.