Biological activity of feijoa peel extracts.
Fractionated extracts of Feijoa peels were studied for cytotoxic activity, anti-human immunodeficiency virus (HIV) activity and antibacterial activity. Two most cytotoxic fractions A3 of acetone extract and M2 of methanol extract had potent inhibitory activity against Gram-positive and Gram-negative bacteria as well as fungi tested. Fraction A4 of acetone extract showed multidrug resistance (MDR)-reversal activity comparable with that of verapamil (positive control). These results indicate the therapeutic value of Feijoa peel extracts as potential antimicrobial and MDR-modulating agents.
Motohashi
N
N
Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, Japan.
Kawase
M
M
Shirataki
Y
Y
Tani
S
S
Saito
S
S
Sakagami
H
H
Kurihara
T
T
Nakashima
H
H
Wolfard
K
K
Mucsi
I
I
Varga
A
A
Molnár
J
J
D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010945:Plants, Edible / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts