[Concentration of prothrombin fragments 1+2 (F1+2) and thrombin-antithrombin III complexes (TAT)in patients with primary non-small cell lung cancer, before and after resection].
The aim of our study was to detect the hypercoagulability in patients with lung cancer as well as to search for the marker indicating the effectiveness of tumour resection. Twenty four patients aged: 47-66 years were included into the study. The control group comprised 24 healthy human beings. The plasma concentrations of prothrombin 1 + 2 fragments (F1 + 2) and thrombinantithrombin III complexes (TAT) were measured before and 10 days after the tumour resection. It was shown, that F1 + 2 was a more sensitive hypercoagulability marker in patients with NSCLC, than TAT concentrations. Ten days after tumour resections, 78% of the patients have a normal level of TAT, while only 42% showed normalization of F1 + 2 concentrations. Our data indicate on coagulation activation in patients with different histological types of lung cancer. The risk of thromboembolic disorders still remains 10 days after tumour resection.
Kostecka
I A
IA
Zakład Diagnostyki Hematologicznej Samodzielny Publiczny Szpital Kliniczny Akademii Medycznej w Białymstoku.
Haponowicz
B
B
Sienkiewicz
P
P
Wierzbicka
M
M
D000328:Adult; D000368:Aged; D000990:Antithrombin III; D014408:Biomarkers, Tumor / Q000097:blood*; D002289:Carcinoma, Non-Small-Cell Lung / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood*; D010447:Peptide Hydrolases / Q000097:blood*; D011498:Protein Precursors / Q000097:blood*; D011516:Prothrombin; D012680:Sensitivity and Specificity; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D010446:Peptide Fragments; D011498:Protein Precursors; C046193:antithrombin III-protease complex; C029733:prothrombin fragment 1; C044183:prothrombin fragment 2; D000990:Antithrombin III; D011516:Prothrombin; D010447:Peptide Hydrolases
Stezenie fragmentów protrombiny 1 + 2 (F1 + 2) i kompleksów trombina-antytrombina III (TAT) u pacjentów z pierwotnym niedrobnokomórkowym rakiem płuca, przed i po resekcji.