[Assessment of metastatic potential of pulmonary carcinoma].
The authors evaluated in a group of 25 patients after radical lung resection on account of a non-small cell carcinoma the correlation between tumour grading, invasion into lymphatic and blood vessels, proliferation markers (Ki-67, PCNA), ploidy, cell polymorphism and mitotic cell activity of the lung tumour and the lymphogenic or haematogenic metastatizing proved before or during surgery. From the investigation patients after induction chemotherapy were eliminated. It was of interest that the great majority of investigated parameters was positive or elevated in patients with lymphogenic or haematogenic metastases. Conversely in patients where the majority of these parameters was negative on the day of the operation, no metastases were detected. In the group of patients where the investigated indicators were positive and no metastasis was found, similarly as in both previous sub-groups, the author will continue to follow-up the following: recurrence, median survival and five-year survival. From the assembled parameters a table was prepared stratifying the risk of metastases.
Klein
J
J
I. chirurgická klinika LF UP a FN, Olomouc.
Bohanes
T
T
Tichý
T
T
Král
V
V
Kolek
V
V
Riháková
P
P
Skarda
J
J
Neoral
C
C
Aujeský
R
R
Grygárková
I
I
D014408:Biomarkers, Tumor / Q000032:analysis*; D002289:Carcinoma, Non-Small-Cell Lung / Q000556:secondary* / Q000601:surgery; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery; D008207:Lymphatic Metastasis; D009361:Neoplasm Invasiveness; D012307:Risk Factors
D014408:Biomarkers, Tumor
Odhad metastatického potenciálu plicního karcinomu.