title: New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position.
abstract: Incorporation of a basic aminopyridine into the C-7 position of 3-(amine-substituted arylthio)-3-norcephalosporins, as in 3, afforded high potency against MRSA and acceptable solubility for intravenous administration.
authors.affiliation: Microcide Pharmaceuticals, Inc., Mountain View, CA 94043, USA. acho@microcide.com
authors.forename: A
authors.initials: A
authors.lastname: Cho
authors.forename: T W
authors.initials: TW
authors.lastname: Glinka
authors.forename: M
authors.initials: M
authors.lastname: Ludwikow
authors.forename: A T
authors.initials: AT
authors.lastname: Fan
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: S J
authors.initials: SJ
authors.lastname: Hecker
mesh_terms: D000631:Aminopyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D000631:Aminopyridines; D002511:Cephalosporins; C420727:RWJ 54428