title: [Effect of colforsin daropate hydrochloride after cardiopulmonary bypass].
abstract: We evaluated the effects of colforsin daropate hydrochloride (CDH) after cardiopulmonary bypass (CPB) in comparison with milrinone. CDH or milrinone were given during and after CPB combined with cathecholamines so as to maintain mean arterial pressure (mABP > 60 mmHg) and cardiac index (CI > 3.0 l.min-1.m-2). Hemodynamics measurement was done immediately after CPB (A 1), one hour after CPB (A 2) and after the chest closure (A 3). In CDH group, mABP was significantly higher compared with milrinone group. Also, CDH group showed a significant reduction in the cases of combined use of dobutamine (at A 2, A 3) and norepinephrine (at A 1, A 2) compared with milrinone group. In conclusion, colforsin daropate hydrochloride exerts more inotropic effect and could reduce the necessity of combined use of cathecholamine compared with milrinone.
authors.affiliation: Department of Anesthesiology, Nara Medical University, Kashihara 634-8522.
authors.forename: K
authors.initials: K
authors.lastname: Sha
authors.forename: T
authors.initials: T
authors.lastname: Morooka
authors.forename: T
authors.initials: T
authors.lastname: Shimoda
authors.forename: T
authors.initials: T
authors.lastname: Horiuchi
authors.forename: T
authors.initials: T
authors.lastname: Iwatsubo
authors.forename: N
authors.initials: N
authors.lastname: Kurita
authors.forename: K
authors.initials: K
authors.lastname: Kitaguchi
authors.forename: H
authors.initials: H
authors.lastname: Furuya
mesh_terms: D000368:Aged; D000771:Anesthesia, Intravenous; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002395:Catecholamines / Q000008:administration & dosage / Q000494:pharmacology; D005576:Colforsin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D020105:Milrinone / Q000008:administration & dosage / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D010726:Phosphodiesterase Inhibitors / Q000008:administration & dosage / Q000494:pharmacology; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D002395:Catecholamines; D010726:Phosphodiesterase Inhibitors; D014665:Vasodilator Agents; C122001:colforsin daropate; D005576:Colforsin; D020105:Milrinone