Hypolipidemic, hypoprostatic and pharmacological activity of oxohexaene polyene antibiotic (HA-1-92).
HA-1-92, a new oxohexaene polyene macrolide showed significant hypolipidemic and hypoprostatic activity both in rat and rabbit models. HA-1-92 did not elicit significant effect on blood pressure or respiration in anaesthetized rat or on various isolated tissue preparation studies.
Naik
S R
SR
Research & Development Division, Hindustan Antibiotics Limited, Pimpri, Pune 411 018, India.
Harindran
J
J
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000633:toxicity; D000960:Hypolipidemic Agents / Q000494:pharmacology* / Q000633:toxicity; D008055:Lipids / Q000097:blood; D018942:Macrolides; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000033:anatomy & histology / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D000900:Anti-Bacterial Agents; C121411:HA-1-92; D000960:Hypolipidemic Agents; D008055:Lipids; D018942:Macrolides