Distribution and pharmacokinetics of the gonadotrophin releasing hormone analogue (Gn-RH analogue) dalarelin in rats.
The dynamics of concentration changes for dalarelin in the blood as well as in organs and tissues at different times from its administration to female rats as a single subcutaneous injection, was observed. Also, the basic pharmacokinetic parrameters were determined. The maximum concentration of dalarelin in the blood (Cmax), which was 261.5 pg/cm3, was observed at the maximum time (tmax) 30 min, after its subcutaneous administration. The simplest equation describing the observed concentration changes for dalarelin in the blood is a tri-exponential equation of an open two-compartment model. The obtained results indicate that dalarelin is selectively captured by the pituitary as well as by the non-specific organs: heart, brain and uterus. It allows us to conclude that it has a wider spectrum of activity.
Dolinska
B
B
Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, 41-205 Sosnowiec, ul. Kasztanowa 3, Poland.
Ryszka
F
F
Suszka-Switek
A
A
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
C404725:dalarelin; D007987:Gonadotropin-Releasing Hormone