Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus.
Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 microM.
Sakuda
S
S
Department of Applied Biological Chemistry, The University of Tokyo, Japan.
Ono
M
M
Ikeda
H
H
Nakamura
T
T
Inagaki
Y
Y
Kawachi
R
R
Nakayama
J
J
Suzuki
A
A
Isogai
A
A
Nagasawa
H
H
D000348:Aflatoxins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
D000348:Aflatoxins; D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones; C420726:blasticidin A