[Cytokine profile and fibrinogen level in blood plasma in diabetic foot under the action of heparin].
The investigation displayed in the article was conducted in order of estimating the content of interleukin-1, tumornecrotic factor and fibrinogen in the patients suffering from the I and II type diabetes mellitus complicated by the lower extremity inflammatory-necrotic process. The type II diabetes was shown to have these substances level as higher as the I one, increasing even more at administrating heparin to the patients. The manifestation of hypercoagulative properties of the latter, as it's postulated, is a result of increasing the synthesis of proinflammatory cytokines.
Harbarchuk
O I
OI
Ukrainian Scientific-Practical Center of Endocrine Surgery, Endocrine Organs and Tissues Transplantation of Ukraine Ministry of Public Health.
D003922:Diabetes Mellitus, Type 1 / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood; D017719:Diabetic Foot / Q000097:blood* / Q000188:drug therapy; D005340:Fibrinogen / Q000378:metabolism*; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D005340:Fibrinogen; D006493:Heparin
Tsytokinovyĭ profil' ta vmist fibrynohenu u plazmi krovi pry syndromi diabetychnoï stopy ta za vplyvu heparinu.