title: Correlation between MRI findings and long-term outcome in patients with severe brain trauma.
abstract: Our aim was to relate MRI findings in patients with severe traumatic brain injury (TBI) to clinical severity and long-term outcome. We studied 37 patients with severe TBI, who were submitted to clinical assessment for disability and cognition and to MRI 60-90 days after trauma. Clinical assessment was also performed 3, 6 and 12 months later. The number and volume of lesions in various cerebral structures were calculated semiautomatically from FLAIR and fast field-echo images. Possible correlations between total and regional lesion volume and clinical deficits were then investigated. The frontal and temporal lobes were most frequently involved. Total lesion volume on FLAIR images correlated significantly with clinical outcome, whereas that on FFE images did not. Regional analysis showed that FLAIR lesion volume in the corpus callosum correlated significantly with scores on disability and cognition scales at the first clinical assessment. FLAIR lesion volume in the frontal lobes correlated significantly with clinical scores 1 year later.
authors.affiliation: Department of Neurological Sciences, Neuroradiology Section, University La Sapienza, Roma, Italy. pierallini@axrma.uniroma.it
authors.forename: A
authors.initials: A
authors.lastname: Pierallini
authors.forename: P
authors.initials: P
authors.lastname: Pantano
authors.forename: L M
authors.initials: LM
authors.lastname: Fantozzi
authors.forename: M
authors.initials: M
authors.lastname: Bonamini
authors.forename: R
authors.initials: R
authors.lastname: Vichi
authors.forename: R
authors.initials: R
authors.lastname: Zylberman
authors.forename: F
authors.initials: F
authors.lastname: Pisarri
authors.forename: C
authors.initials: C
authors.lastname: Colonnese
authors.forename: L
authors.initials: L
authors.lastname: Bozzao
mesh_terms: D000293:Adolescent; D000328:Adult; D001930:Brain Injuries / Q000473:pathology* / Q000534:rehabilitation; D002648:Child; D003072:Cognition Disorders / Q000209:etiology*; D003337:Corpus Callosum / Q000473:pathology*; D006233:Persons with Disabilities; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D012720:Severity of Illness Index; D013702:Temporal Lobe / Q000473:pathology