Synthesis of new pyridoquinoxalines, thienopyridoquinoxalines and pyrimidothienopyridoquinoxalines.
Synthesis of 3-chloro-2-cyanoquinoxaline (1) and its reactions with sodium azide, guanidine hydrochloride, semicarbazide and thioheterocycles have been investigated (2-7). Also, the reaction of the chloro compound 1 with cyanoacetamide or cyanothioacetamide gave the pyrido[2,3-b]quinoxaline derivatives 8, 9. Compound 9 was used as a key intermediate to produce the more polyheterocyclic systems 10-18.
Moustafa
O S
OS
Chemistry Department, Faculty of Science, Assiut University, Assiut, Egypt.
Badr
M Z
MZ
Kamel
E M
EM
D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011725:Pyridines / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*; D011810:Quinoxalines / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared; D013876:Thiophenes / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D011725:Pyridines; D011743:Pyrimidines; D011810:Quinoxalines; D013876:Thiophenes