[Anaphylactic reactions to aprotinin: intradermal diagnostic  tests]  .
A 66-year-old patient, undergoing heart surgery, developed an anaphylactic reaction following the first administration of a test-dose of aprotinin. Skin tests were performed six months later. Prick-tests with 10(-2) and 10(-1) aprotinin dilutions were negative but intradermal reaction with a 10(-3) dilution was clearly positive. The level of aprotinin specific IgE was high, both in the serum obtained before surgery and in the one sampled on the day of the testing. As no reaction was observed during the tests, skin-testing and specific IgE appear to be an interesting alternative to a potentially dangerous test-dose, but they both need further evaluation.
Pecquet
C
C
Centre d'allergologie, hôpital Tenon, 4, rue de la Chine, 75020 Paris, France.
Autegarden
J E
JE
Kural-Menasche
S
S
Perez
G
G
Menasche
P
P
Sanson-LePors
M J
MJ
Abuaf
N
N
Leynadier
F
F
D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced* / Q000175:diagnosis; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007611:Aprotinin / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007271:Injections, Intradermal; D010323:Passive Cutaneous Anaphylaxis; D012882:Skin Tests
D000998:Antiviral Agents; D007073:Immunoglobulin E; D007611:Aprotinin
Réaction anaphylactique à l'aprotinine: intérêt diagnostique des tests intradermiques.