[Value of the detection of serum thyroglobin and I-131 scintigraphy in the follow-up of differentiated thyroid cancer].
OBJECTIVE
The objective of this work has been to know the sensitivity of serum thyroglobulin and I-131 scintigraphy in the detection of thyroid remnants or metastases, and to evaluate the predictive value of serum thyroglobulin in the follow-up of differentiated thyroid cancer patients.


METHODS
We have carried out a retrospective study of 218 patients with differentiated thyroid cancer, with detection of serum thyroglobulin levels and I-131 scintigraphy in clinical status of hypothyroidism, after to perform thyroidectomy and between six and nine months later. We have rejected 16 and 14 patients who have had presented high serum levels of thyroglobulin, or an incomplete follow-up.


RESULTS
Our results showed a good correlation of both parameters (92%). The sensitivity of TG and I-131 scan was 85% and 90% respectively, and superior to 90% for both procedures in the diagnosis of the osseous and lung metastases. The sensitivity of I-131 scan and TG was 100% and less to 70% in the detection of thyroid remnants and regional lymphatic nodes. The positive and negative value of TG was 99% and 91%, respectively, with a total of 24 false negative results.


CONCLUSIONS
Considering this study, we believe that both techniques are complementary, with a lower sensitivity of serum TG in the detection of thyroid remnants and regional lymphatic involvement, and a negative predictive value that does not permit to accomplish the follow-up of differentiated thyroid cancer patients, considering exclusively the results of this tumoral marker.
Ruiz Hernández
G
G
Hospital Clínico Universitario, Servicio de Medicina Nuclear, Instituto Valenciano Oncológico (IVO), Valencia.
Vázquez Forner
C
C
Fliquete Peris
M V
MV
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D013954:Thyroglobulin / Q000097:blood*; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology*
D015415:Biomarkers; D007457:Iodine Radioisotopes; D013954:Thyroglobulin
Valor de la determinación de la tiroglobulina sérica y de la gammagrafía mediante I-131 en el seguimiento del cáncer diferenciado de tiroides.