title: Acute toxicity of LAS homologues in marine microalgae: esterase activity and inhibition growth as endpoints of toxicity.
abstract: The toxicity of two linear alkylbenzene sulfonate (LAS) homologues (C(10) and C(13)) was evaluated in four marine microalgae (Nannochloropsis gaditana, Tetraselmis suecica, Rhodomonas salina, and Isocrysis galbana), using growth inhibition rate and esterase activity (measured by flow cytometry) as endpoints. The inhibitor effect was higher for the C(13) LAS homologue than for C(11), in both responses analyzed. When both endpoints were compared, the growth inhibition rate was between 2 and 5 times more sensitive than esterase activity. Among microalgae species, R. salina exhibited the highest sensitivity.
authors.affiliation: Instituto de Ciencias Marinas de Andalucía CSIC, Campus Río San Pedro, 11510 Puerto Real, Cádiz, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Hampel
authors.forename: I
authors.initials: I
authors.lastname: Moreno-Garrido
authors.forename: C
authors.initials: C
authors.lastname: Sobrino
authors.forename: L M
authors.initials: LM
authors.lastname: Lubián
authors.forename: J
authors.initials: J
authors.lastname: Blasco
mesh_terms: D017738:Alkanesulfonic Acids / Q000633:toxicity*; D017377:Diatoms / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D004950:Esterases / Q000378:metabolism*; D005434:Flow Cytometry; D006128:Growth / Q000187:drug effects; D012623:Seawater; D012680:Sensitivity and Specificity; D013045:Species Specificity; D013501:Surface-Active Agents / Q000633:toxicity*; D018675:Toxicity Tests
chemical_list: D017738:Alkanesulfonic Acids; D013501:Surface-Active Agents; C030641:alkylbenzyl sulfonic acid; D004950:Esterases