title: Perirolandic hypoperfusion on single-photon emission computed tomography in term infants with perinatal asphyxia: comparison with MRI and clinical findings.
abstract: We describe the findings on single-photon emission computed tomography (SPECT) in patients with perinatal asphyxia at term, with perirolandic cortico-subcortical changes on MRI, and to correlate them with clinical features. SPECT of 7 patients was obtained after injection of 185-370 MBq of Tc-99m-ECD (ethyl cysteinate dimer). The patients had spastic quadriplegia (7/7) with perinatal asphyxia (6/7) at term (7/7). The results were correlated with the MRI findings. Hypoperfusion of the perirolandic cortex was clearly seen on SPECT in all patients, even in two with subtle changes on MRI. SPECT demonstrated a more extensive area of involvement than MRI, notably in the cerebellum (in 4), the thalamus (in 7) and basal ganglia (in 5), where MRI failed to show any abnormalities.
authors.affiliation: Division of Nuclear Medicine, Department of Diagnostic Radiology, Yongdong Severance Hospital, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: C S
authors.initials: CS
authors.lastname: Yoon
authors.forename: Y H
authors.initials: YH
authors.lastname: Ryu
authors.forename: D I
authors.initials: DI
authors.lastname: Kim
authors.forename: C I
authors.initials: CI
authors.lastname: Park
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: P H
authors.initials: PH
authors.lastname: Yoon
authors.forename: T J
authors.initials: TJ
authors.lastname: Jeon
authors.forename: J D
authors.initials: JD
authors.lastname: Lee
mesh_terms: D001238:Asphyxia Neonatorum / Q000150:complications / Q000000981:diagnostic imaging*; D001479:Basal Ganglia / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D002675:Child, Preschool; D003545:Cysteine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D007744:Obstetric Labor Complications; D015609:Organotechnetium Compounds; D011247:Pregnancy; D011782:Quadriplegia / Q000000981:diagnostic imaging* / Q000209:etiology; D019275:Radiopharmaceuticals; D013788:Thalamus / Q000473:pathology; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine