title: Pharmacodynamic study of Hypericum perforatum L.
abstract: The effects of Hypericum perforatum L. (Hypericaceae) crude ethanol extract (A), ethyl acetate extract (B), aqueous extract (C) and infusion (I), on pentobarbital induced sleeping time, intestinal motility, and their analgesic activity, have been investigated. Extracts A and B exhibited significant stimulatory and antidepressant effects on the CNS. Both extracts prolonged sleep, increasing time up to more than 25 min. The antidepressive activity of extract A was also achieved by significant reduction of the myorelaxant activity of diazepam. Extract B exhibited strong analgesic activity reducing abdominal stretching induced by acetic acid by nearly 50 %. Extracts A, B and C exhibited spasmolytic activity, significantly reducing intestine motility.
authors.affiliation: Institute of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Yugoslavia.
authors.forename: V
authors.initials: V
authors.lastname: Jakovljević
authors.forename: M
authors.initials: M
authors.lastname: Popović
authors.forename: N
authors.initials: N
authors.lastname: Mimica-Dukić
authors.forename: A
authors.initials: A
authors.lastname: Sabo
authors.forename: L
authors.initials: L
authors.lastname: Gvozdenović
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D020902:Hypericum; D006993:Hypnotics and Sedatives; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology; D010424:Pentobarbital; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D012890:Sleep / Q000187:drug effects*
chemical_list: D000700:Analgesics; D000928:Antidepressive Agents; D006993:Hypnotics and Sedatives; D010276:Parasympatholytics; D010936:Plant Extracts; D010424:Pentobarbital; D019342:Acetic Acid