Effect of methyl substitution on mutagenicity of 2-aminodipyrido.
The mutagenicities of 2-aminodipyrido [1,2-a:3',2'-d] imidazole (Glu-P-2, a mutagen obtained from pyrolysate of glutamic acid) and six methyl substituted derivatives of Glu-P-2 were tested with Salmonella typhimurium TA98 and TA100 with S-9 mix. Glu-P-1 (6-Me-Glu-P-2) was the strongest mutagen to TA98 and TA100. 3-Me-Glu-P-2 was weakest. The presence of a methyl group, and its position were shown to affect the mutagenicity significantly.
Takeda
K
K
Faculty of Pharmaceutical Sciences, University of Tokyo, Japan.
Shudo
K
K
Okamoto
T
T
Nagao
M
M
Wakabayashi
K
K
Sugimura
T
T
D007093:Imidazoles / Q000138:chemical synthesis / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis / Q000633:toxicity*; D013329:Structure-Activity Relationship
D007093:Imidazoles; D009153:Mutagens; C023785:2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; C023847:Glu-P-2