Molecular aspects of procyanidin biological activity: disease preventative and therapeutic potentials.
There is a growing interest in the utilization of procyanidins for their dietary and pharmacological properties. A wide spectrum of beneficial activity for human health has been advocated for procyanidins due, in part, to their strong antioxidant activity. More recently the ability of procyanidins to affect gene expression and cell response in vitro has been reported, providing a novel mechanistic perspective on the biological activity of these phytochemicals. This article reviews recent cellular and molecular aspects of the biological activity of procyandins and discusses their disease preventative and therapeutic potentials.
Moini
H
H
Department of Molecular Pharmacology and Toxicology, School of Pharmacy, University of Southern California, Los Angeles, USA.
Rimbach
G
G
Packer
L
L
D000818:Animals; D001682:Biological Availability; D018938:Caco-2 Cells / Q000378:metabolism; D002319:Cardiovascular System / Q000187:drug effects; D002392:Catechin / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D002645:Chickens; D004285:Dogs; D015870:Gene Expression / Q000187:drug effects; D000882:Haplorhini; D006801:Humans; D051379:Mice; D016328:NF-kappa B / Q000187:drug effects; D019001:Nitric Oxide Synthase / Q000187:drug effects; D052247:Nitric Oxide Synthase Type II; D010084:Oxidation-Reduction; D011108:Polymers / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D051381:Rats; D015398:Signal Transduction / Q000187:drug effects
D016328:NF-kappa B; D011108:Polymers; D002392:Catechin; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; C496318:Nos2 protein, rat