title: Echocardiographic findings of pericardial involvement in patients with malignant pleural mesothelioma with a history of environmental exposure to asbestos and erionite.
abstract: OBJECTIVE
  The aim of the present study was to evaluate the pericardial involvement in patients with malignant mesothelioma caused by exposure to different minerals.
  
  
  METHODS
  Forty-two patients (mean age of 52 +/- 12 years) with malignant mesothelioma were examined with transthoracic echocardiography. Thirty-three (78.9%) patients had a history of environmental exposure to asbestos and nine (21.4%) had a history of environmental exposure to erionite.
  
  
  RESULTS
  In 19 (45.2%) patients with malignant pericardial mesothelioma, pericardial involvement was determined by echocardiography. The other 23 (54.8%) patients had no pericardial involvement. Pericardial effusion was detected in nine (64.3%) patients and pericardial effusion was small in six (14.3%) patients, moderate in one (2.4%) patient and large in two patients. Thickening of the pericardium was observed in eight (19%) patients. In another two (7.1%) patients pericardial calcification was observed. Among the 33 patients who had been exposed to asbestos, 15 (45.5%) had pericardial involvement, and among the nine patients with a history of exposure to erionite, four (44.4%) had pericardial involvement. There was no difference in terms of pericardial involvement in different stages of the tumour (P > 0.05).
  
  
  CONCLUSIONS
  Pericardial involvement is commonly seen in patients with malignant mesothelioma. Among patients exposed to asbestos or zeolite there was no difference in terms of pericardial involvement. Furthermore, pericardial involvement was not related with the stage of the tumour.
authors.affiliation: Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara, Turkey. nozer@softhome.net
authors.forename: N
authors.initials: N
authors.lastname: Ozer
authors.forename: V
authors.initials: V
authors.lastname: Shehu
authors.forename: K
authors.initials: K
authors.lastname: Aytemir
authors.forename: K
authors.initials: K
authors.lastname: Ovünç
authors.forename: S
authors.initials: S
authors.lastname: Emre
authors.forename: S
authors.initials: S
authors.lastname: Kes
mesh_terms: D000328:Adult; D000368:Aged; D001194:Asbestos / Q000009:adverse effects*; D001784:Blood Gas Analysis; D002273:Carcinogens / Q000009:adverse effects*; D004452:Echocardiography; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008654:Mesothelioma / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D010490:Pericardial Effusion / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000473:pathology; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000473:pathology; D012129:Respiratory Function Tests; D017641:Zeolites / Q000009:adverse effects*
chemical_list: D002273:Carcinogens; C083174:erionite; D017641:Zeolites; D001194:Asbestos