title: Physico-chemical characterization of polysaccharide vaccines.
abstract: An increasing number of sophisticated analytical techniques, including NMR spectroscopy, are currently being applied to the quality control of polysaccharide and polysaccharide-based vaccines. These methodologies are providing more precise and more detailed profiles of these vaccines. NMR spectroscopy also provides a convenient and powerful technique to monitor alterations of the polysaccharide in the production of protein conjugate vaccines.
authors.affiliation: Office of Vaccines Research and Review, Center for Biologics Evaluation and Research, FDA, Bethesda, MD 20852, USA.
authors.forename: W
authors.initials: W
authors.lastname: Egan
mesh_terms: D001419:Bacteria / Q000737:chemistry; D001428:Bacterial Vaccines / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D011135:Polysaccharides, Bacterial / Q000737:chemistry*
chemical_list: D001428:Bacterial Vaccines; D011135:Polysaccharides, Bacterial