The effects of soy protein in women and men with elevated plasma lipids.
Fifty four postmenopausal women with elevated cholesterol were recruited for a randomised, double-blind controlled trial of soy protein containing isoflavones. (ISP+) or a soy protein with a low isoflavone content (ISP-), taken daily for 12 weeks. There was an overall reduction after 12 weeks in total cholesterol (TC), LDL cholesterol (LDL-C), sex hormone binding globulin (SHBG), and luteinizing hormone (LH). There were no significant differences between treatment groups. In a separate study 27 male subjects with a TC > 5.5 mmol/l were given ISP+ for 12 weeks. In this male study there was a significant increase in HDL cholesterol (HDL-C) and SHBG. Soy protein has a cholesterol lowering effect in both women and men. These studies suggest that this effect is independent of isoflavones. Soy protein also reduces SHBG levels in both sexes.
Mackey
R
R
Sydney Menopause Centre, Royal Hospital for Women, Randwick, NSW, Australia.
Ekangaki
A
A
Eden
J A
JA
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D007529:Isoflavones / Q000008:administration & dosage / Q000627:therapeutic use*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D017698:Postmenopause; D011446:Prospective Studies; D012727:Sex Characteristics; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D030262:Soybean Proteins / Q000008:administration & dosage / Q000627:therapeutic use*; D013972:Thyrotropin / Q000097:blood; D014280:Triglycerides / Q000097:blood
D000596:Amino Acids; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007529:Isoflavones; D012738:Sex Hormone-Binding Globulin; D030262:Soybean Proteins; D014280:Triglycerides; D015675:Osteocalcin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; C036020:deoxypyridinoline; D002784:Cholesterol; D000469:Alkaline Phosphatase