Effects of chronic insulin treatment on blood pressure in rats.
There is an evident epidemiological association between plasma insulin levels and blood pressure. The mechanism that relates insulin to blood pressure and the role of insulin in the pathogenesis of arterial hypertension have not been clearly defined. The present study was designed to examine the effects of chronic hyperinsulinism on blood pressure and to determine different related morphological variables. WistarKyoto rats were subcutaneously injected with insulin (25 UI/Kg of weight) daily during the eight weeks of the experiment. Data were collected on systolic and diastolic arterial pressures and heart rate by plethysmography and direct recording (in the last week), and on morphological variables. A statistically significant elevation of systolic arterial pressure was produced after the sixth week of hyperinsulinaemia. At the end of the treatment, the systolic arterial pressure was 173.7 +/- 26.1 in the hyperinsulinaemic rats versus 153.09 +/- 21.7 in the control group. The values obtained by direct recording and by plethysmography did not differ. These results indicate that chronic hyperinsulinism produces a significant elevation in systolic blood pressure levels in the rats studied.
Bermúdez
M C
MC
Depto de Fisiología, Instituto de Neurociencias, Facultad de Medicina, Universidad de Granada, Spain.
Pardo
P
P
Martínez-García
O M
OM
García Torres
L
L
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D001795:Blood Pressure Determination / Q000379:methods; D002408:Catheters, Indwelling; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000503:physiopathology; D006946:Hyperinsulinism / Q000139:chemically induced / Q000503:physiopathology*; D006973:Hypertension / Q000503:physiopathology*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D010991:Plethysmography; D051381:Rats; D011921:Rats, Inbred WKY; D013623:Tail
D007004:Hypoglycemic Agents; D007328:Insulin