title: [Screening for breast cancer on basis of individual risk assessment for women ineligible for the national population screening program].
abstract: For healthy women, without malignancies in their personal histories, a positive family history for breast cancer is the single indication for individual breast surveillance outside the population screening. Management of women is based on individual risk assessment. A cumulative risk of 20% and more, as a result of a positive family history, will in practice be an indication for breast surveillance. This threshold is not evidence-based yet, nor are data available on the benefits of this surveillance efficacy. When a personal cumulative risk of more than 30% exists to develop breast cancer, a consultation with a clinical geneticist involved in a family cancer clinic should be offered. Surveillance of women with a high-risk cumulative risk should preferably be included in a prospective study design. Only in this way will data about compliance and the estimates of different ways of surveillance become available. There is no convincing evidence that population screening for women aged 40-49 years does lead to important mortality reduction in combination with a good balance between pros and cons for the women involved. Women in the age category 50-75 years, with breast cancer in their personal histories, who are not followed anymore, should be informed by their specialist about participating (again) in the population breast screening. There is no evidence of mortality reduction as a result of breast self-examination nor of palpation performed by a physician. However, awareness of the own body can be useful for early recognition of breast abnormalities; it may reduce the delay between the first recognizable symptom and the subsequently initiated therapy.
authors.affiliation: Leids Universitair Medisch Centrum, Postbus 9600, 2300 RC Leiden, Afd. Klinisch Genetisch Centrum Leiden. c.j.vanasperen@kgc.azl.nl
authors.forename: C J
authors.initials: CJ
authors.lastname: van Asperen
authors.forename: G H
authors.initials: GH
authors.lastname: de Bock
authors.forename: F
authors.initials: F
authors.lastname: van der Horst
authors.forename: H J
authors.initials: HJ
authors.lastname: de Koning
authors.forename: E J
authors.initials: EJ
authors.lastname: Rutgers
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000517:prevention & control*; D016504:Breast Self-Examination / Q000379:methods; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008279:Magnetic Resonance Imaging; D008327:Mammography; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D009426:Netherlands; D017410:Practice Guidelines as Topic; D018570:Risk Assessment / Q000379:methods; D014463:Ultrasonography
vernacular_title: Screening op mammacarcinoom buiten het landelijke bevolkingsonderzoek, op grond van individuele risico-inschatting.