title: Disodium clodronate in painful nonresponsive periarthropathy of the hip.
abstract: This article identifies and describes a small group of patients with trochanteric tendinitis and bursitis in whom all modes of traditional therapy failed. We hypothesized that obstinate pain could be due to an increase in bone turnover associated with the formation of marginal bony outgrowths or enthesophytes. Injectable disodium clodronate is known to be highly efficacious in inhibiting bone reabsorption and is able to reduce several types of bone pain. The aim of the study was to evaluate the effectiveness of disodium clodronate in periarticular pathology of the hip in a group of patients resistant to traditional treatments and who were hypothesized to have a component of bone pain in their pain syndrome. Periarticular ultrasound examination is a useful method for detecting soft tissue alterations and is of interest in the study of these patients. In this study ultrasound examination showed periarticular alterations even when results of radiography were negative. Reduction in the hyperechoic ultrasound image, which confirms periarticular calcification, was observed in 75% of the patients treated with disodium clodronate vs. 33% of those treated with paracetamol. At the end of the study, all patients treated with disodium clodronate had a reduction in spontaneous and provoked pain > or = 1/3 vs. the basal visual analogue scale, unlike those treated with paracetamol.
authors.affiliation: E. Bruzzone Rheumatology Center, DISEM, University of Genoa, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Monteforte
authors.forename: L
authors.initials: L
authors.lastname: Molfetta
authors.forename: G
authors.initials: G
authors.lastname: Grillo
authors.forename: A
authors.initials: A
authors.lastname: Brignone
authors.forename: G
authors.initials: G
authors.lastname: Rovetta
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage; D000368:Aged; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage*; D001862:Bone Resorption / Q000188:drug therapy* / Q000473:pathology; D002062:Bursitis / Q000188:drug therapy* / Q000473:pathology; D004002:Clodronic Acid / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005269:Femur / Q000473:pathology; D006621:Hip Joint / Q000473:pathology; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy* / Q000473:pathology; D010147:Pain Measurement; D052256:Tendinopathy / Q000188:drug therapy* / Q000473:pathology
chemical_list: D018712:Analgesics, Non-Narcotic; D004002:Clodronic Acid; D000082:Acetaminophen