title: Resolution of positional isomers by capillary electrochromatography.
abstract: Electroseparations have been very successful in increasing efficiencies and reducing analysis times. The analytical technique originally applied to open tube capillaries (capillary electrophoresis) has been used as a basis to develop renewed interest in electrochromatography. This paper describes the use of capillary electrochromatography to separate two positional isomers and describes a comparison between gas chromatography (GC), capillary electrochromatography (CEC) and nano-HPLC. The resolution of these isomers is quite crucial, since one of the isomers is the impurity in a pharmaceutically active drug.
authors.affiliation: Development Chemistry 5, Chemical Development Division, GlaxoWellcome Medicines Research Centre, Stevenage, Herts, UK.
authors.forename: D
authors.initials: D
authors.lastname: Hindocha
authors.forename: N W
authors.initials: NW
authors.lastname: Smith
mesh_terms: D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D007536:Isomerism