[Production and characterization of an atenolol-reticulated povodone tablet].
The production of polymeric complexes in many active drugs with reticulated povidone increased dissolved component percentage. In this work made use a coevaporation technique. Complex formation has been tested by X Ray Diffractometry and Differential Scanning Calorimetry. The percentage of dissolution was determined to the USP XXIII Edition methodology. As can be seen from the results, the Atenolol-reticulated Povidone complexes has greater solubility than the Atenolol mixed with Lactose as excipient.
Dobrecky
J
J
Universidad de Buenos Aires, Facultad de Farmacia y Bioquímica, Departamento de Tecnología Farmacéutica, Junín 956, Piso 6o, (1113) Buenos Aires, Argentina.
Bregni
C
C
Lamas
M C
MC
Cancelo
G
G
Estévez
S M
SM
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000737:chemistry*; D001262:Atenolol / Q000008:administration & dosage / Q000737:chemistry*; D002152:Calorimetry, Differential Scanning; D004339:Drug Compounding; D010592:Pharmaceutic Aids; D011205:Povidone / Q000737:chemistry*; D012995:Solubility; D014961:X-Ray Diffraction
D000319:Adrenergic beta-Antagonists; D010592:Pharmaceutic Aids; D001262:Atenolol; D011205:Povidone
Obtención y caracterización de un complejo de atenolol con povidona reticulada.