[Survival of 2 years and 7 months with 5'-DFUR treatment in a patient with peritoneal gastric cancer recurrence].
A 79-year-old male patient with peritoneal recurrence of gastric cancer 1 year and 7 months after radical operation was treated by oral administration of 5'-DFUR. After the beginning of oral administration of 5'-DFUR, he survived 2 years and 7 months with a good performance status and without any adverse effects. A very limited number of cases with long survival by the oral administration of 5'-DFUR after peritoneal recurrence of gastric cancer have been reported. Of a total of 653.0 g of 5'-DFUR administrated, 436.8 g (66.9%) were given in a protocol consisting of daily oral 1,600 mg of 5'-DFUR for 7 consecutive days and 7 drug free days. This high-dose (1,053 mg/m2/day) and intermittent method of 5'-DFUR administration might have contributed to the long survival and good performance status of this patient.
Tamiya
Y
Y
Division of Surgery, Niigata Prefectural Hospital.
Oyamatu
M
M
Matubara
Y
Y
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005467:Floxuridine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery; D017741:Survivors
D000964:Antimetabolites, Antineoplastic; D005467:Floxuridine; C025034:doxifluridine