[Testing CK group preparations in hymenolepiasis in white mice].
The drugs CK-1 and CK-2 are a kerosene milky-stage walnut (Juglans spp.) extract. The drugs CK-3, CK-4, and CK-5 are derived from monkshood (Aconitum) roots, garlic (Allium sativum), and Ferula, respectively. Albino mice were infected with hymenolepiasis by the procedure of B.A. Astafyev et al. (1989). The mice were aged 3 weeks, weighed 7-8 g, and spontaneous invasion-free. The doses of 25 to 100 mg/kg were tested. The antihelminthic effects of the extragent of the drugs--aircraft kerosine purified by the authors' procedure--were additionally examined. The purified aircraft kerosine was found to have moderate antihelminthic effects, but failed to provide 100% antihelminthic activity when given even in very high doses (500 mg/kg or more). The drug CK-1, 100 mg/kg, completely eliminated hymenolepiasis in the experimental animals. Other drugs CK-3, CK-4, and CK-5 used in doses of 100 mg/kg body weight failed to provide 100% antihelminthic efficiency.
Streliaeva
A V
AV
Chebyshev
N V
NV
Sadykov
V M
VM
D000818:Animals; D000871:Anthelmintics / Q000009:adverse effects / Q000627:therapeutic use*; D006925:Hymenolepiasis / Q000188:drug therapy*; D007648:Kerosene; D008419:Materia Medica; D051379:Mice; D009754:Nuts / Q000737:chemistry*; D010936:Plant Extracts / Q000627:therapeutic use*; D019685:Rosales / Q000737:chemistry*
D000871:Anthelmintics; D007648:Kerosene; D008419:Materia Medica; D010936:Plant Extracts
Ispytanie preparatov gruppy CK pri gimenolipidoze belykh mysheĭ.