[Gabapentin--yet another antiepileptic agent for the treatment of neuropathic pain?].
Gabapentin is a recently introduced anti-epileptic drug used as an adjuvant in partial and secondarily generalised tonic-clonic seizures. Its mechanism of action has not been fully elucidated, but it seems that gabapentin may regulate voltage-dependent calcium channels, presumably on a spinal level, in the nociceptive system. Two large, controlled clinical trials of painful diabetic neuropathy and postherpetic neuralgia have demonstrated its analgesic efficacy. The adverse effects associated with gabapentin treatment are relatively harmless, mild to moderate in severity, and usually transient, with tolerance developing 2-3 weeks after start of treatment. Gabapentin and tricyclic antidepressants are efficacious in the treatment of painful diabetic neuropathy and postherpetic neuralgia.
Kamp-Jensen
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H: S Hvidovre Hospital, smerteklinikken og akut smerteenhed, anaestesiologisk afdeling 532.
Werner
M U
MU
D000085:Acetates / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D000588:Amines; D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics; D002986:Clinical Trials as Topic; D018849:Controlled Clinical Trials as Topic; D003509:Cyclohexanecarboxylic Acids; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D000077206:Gabapentin; D006566:Herpesviridae Infections / Q000150:complications; D006801:Humans; D015337:Multicenter Studies as Topic; D009437:Neuralgia / Q000188:drug therapy* / Q000821:virology; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000700:Analgesics; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin
Gabapentin--endnu et antiepileptikum til behandling af neuropatiske smerter?