title: Guided tissue regeneration with and without demineralized freeze-dried bone allografts for maxillary Class II furca invasions of rapidly progressive periodontitis.
abstract: BACKGROUND
  Guided tissue regeneration (GTR) using an expanded polytetrafluorethylene (ePTFE) membrane is an established treatment modality for periodontal disease. This study was designed to compare the effects of ePTFE membranes with and without demineralized, freeze-dried bone allografts (DFDBA) for treating maxillary class II buccal furca invasions of rapidly progressive periodonitis.
  
  
  METHODS
  Seven patients with pairs of maxillary class II buccal furca invasions comprised the study group. The clinical parameters investigated were probing depth, probing attachment level and marginal tissue recession. One defect from each pair of teeth was randomly selected for the ePTFE membrane and DFDBA group and the other tooth defect received ePTFE membrane treatment only. During the operation, horizontal probing depths at the buccal furcation areas were measured. The membrane was removed 6 weeks after insertion. All measurements were repeated 1 year later at surgical re-entry of the buccal furcation. The Wilcoxon ranked sum test was used to test the significance of the difference between the groups 1 year after treatment.
  
  
  RESULTS
  In the ePTFE membrane and DFDBA group, the mean probing depth reduction was 2.1 +/- 0.8 mm. The probing attachment gain was 2.6 +/- 1.0 mm and the bone fill was 3.1 +/- 1.7 mm. There was no statistically significant difference between the groups for these parameters. The marginal tissue recession was reduced 0.4 +/- 0.7 mm in ePTFE membrane and DFDBA group but increased 0.9 +/- 0.6 mm in ePTFE membrane only group. This difference was statistically significant (p = 0.016).
  
  
  CONCLUSIONS
  There was no difference in probing depth reduction, probing attachment gain or bone fill between the two treatment modalities for treating maxillary class II buccal furca invasion of rapidly progressive periodontitis. Marginal tissue recession can be significantly reduced with the treatment of combined ePTFE membrane and DFDBA.
authors.affiliation: Division of Periodontics, Department of Dentistry, Taipei Veterans General Hospital, National Yang-Ming University, Taipei, Taiwan, ROC.
authors.forename: L J
authors.initials: LJ
authors.lastname: Ling
authors.forename: A R
authors.initials: AR
authors.lastname: Pack
authors.forename: D W
authors.initials: DW
authors.lastname: Holborow
mesh_terms: D000328:Adult; D018775:Bone Demineralization Technique; D016025:Bone Transplantation; D018450:Disease Progression; D005260:Female; D005612:Freeze Drying; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008312:Malocclusion, Angle Class II / Q000628:therapy*; D010518:Periodontitis / Q000473:pathology / Q000628:therapy*; D011138:Polytetrafluoroethylene / Q000627:therapeutic use*
chemical_list: D011138:Polytetrafluoroethylene