title: Differential diagnosis of breast lesions by use of biomagnetic activity and non-linear analysis.
abstract: OBJECTIVE
  Breast cancer mortality rates have not changed during the past 60 years despite significant advances in screening methods. It is tempting therefore to use novel technology in order to better understand breast oncology. In this study we investigated the biomagnetic activity obtained in benign and malignant breast lesions using a single channel biomagnetometer SQUID (Superconducting Quantum Interference Device) in order to assess the method's efficacy in the differential diagnosis of these two types of lesions and its establishment as a screening technique.
  
  
  METHODS
  Magnetic recordings were obtained from 21 patients with palpable breast lumps. Of these 11 were invasive carcinomas and 10 were benign breast lesions. We used non-linear analysis to investigate whether there is any biological differentiation in the dynamics in these two types of lesions.
  
  
  RESULTS
  High amplitudes characterized the waveform of a malignant breast lesion whereas in benign breast lesions the corresponding amplitudes were low. Using the application of non-linear analysis we observed a clear saturation value for the dimension of malignant breast lesions and no saturation for benign ones.
  
  
  CONCLUSIONS
  Biomagnetic measurements with the SQUID and the application of non-linear analysis are promising procedures in assessing and differentiating breast tumors.
authors.affiliation: Lab. of Medical Physics, Medical School, Democritus University of Thrace, Alexandroupolis, Greece.
authors.forename: P A
authors.initials: PA
authors.lastname: Anninos
authors.forename: A
authors.initials: A
authors.lastname: Kotini
authors.forename: N
authors.initials: N
authors.lastname: Koutlaki
authors.forename: A
authors.initials: A
authors.lastname: Adamopoulos
authors.forename: G
authors.initials: G
authors.lastname: Galazios
authors.forename: P
authors.initials: P
authors.lastname: Anastasiadis
mesh_terms: D000328:Adult; D001941:Breast Diseases / Q000175:diagnosis* / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008280:Magnetics; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D017711:Nonlinear Dynamics; D011237:Predictive Value of Tests