[Effectiveness of lymphotropic therapy in patients with tuberculosis in relations to genetic markers].
To study whether a combination of the carriage of genetic blood markers: haptoglobin phenotypes and red blood cell glucose-6-phosphate dehydrogenase, 60 patients with destructive tuberculosis were given a new drug treatment regimen by using regional lymphotropic therapy with 10% isoniazid. The efficiency of the treatment and residual changes were found to be directly related to what a patient has as genetic background. Defining the types of combinations of genetic markers may predict the course of disease, the efficiency of treatment, and outcomes.
Ubaĭdullaev
A M
AM
Belotserkovets
V G
VG
Kazakov
K S
KS
D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase / Q000097:blood / Q000235:genetics*; D006242:Haptoglobins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007272:Injections, Intralymphatic; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D016896:Treatment Outcome; D014397:Tuberculosis, Pulmonary / Q000097:blood / Q000188:drug therapy* / Q000235:genetics
D000995:Antitubercular Agents; D005819:Genetic Markers; D006242:Haptoglobins; D005954:Glucosephosphate Dehydrogenase
Effektivnost' limfotropnoĭ terapii u bol'nykh tuberkulezom legkikh v zavisimosti ot geneticheskikh markerov.