title: Human histologic evaluation of a bone graft combined with GTR in the treatment of osseous dehiscence defects: a case report.
abstract: There are many possible goals and outcomes of periodontal surgical therapy, but the ultimate goal is regeneration. Since the definition of periodontal regeneration is histologic, it is difficult to document. The purpose of this study was to evaluate a technique that combined a bone graft and guided tissue regeneration (GTR) to see if regeneration occurred. Four teeth with dehiscence-type osseous defects that were scheduled for extraction were treated with bone grafts and GTR. During the surgical procedure, a notch was placed into the root at the apical extent of the calculus. The teeth were extracted with conservative block sections 7 months after the treatment. They were processed, sectioned, stained, and evaluated histologically. The results revealed that regeneration did not occur in any of the teeth treated. In 2 of the teeth new connective tissue attachment was formed. In these 2 teeth cementum could be seen in the notch with connective tissue fibers inserting into the cementum. In one of the teeth the junctional epithelium extended apical to the notch, while in 3 cases the epithelium stopped at or coronal to the notch. In this case report, no regeneration could be documented, but new attachment could be seen in 2 of the 4 teeth treated.
authors.forename: R J
authors.initials: RJ
authors.lastname: Harris
mesh_terms: D016301:Alveolar Bone Loss / Q000473:pathology / Q000601:surgery*; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000627:therapeutic use; D016025:Bone Transplantation / Q000473:pathology*; D004396:Coloring Agents; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D017886:Durapatite / Q000627:therapeutic use; D004846:Epithelial Attachment / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005889:Gingival Recession / Q000473:pathology / Q000601:surgery; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery; D012038:Regeneration / Q000502:physiology; D013752:Tetracycline / Q000627:therapeutic use; D014092:Tooth Root / Q000187:drug effects / Q000473:pathology / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D018786:Bone Substitutes; D004396:Coloring Agents; D008567:Membranes, Artificial; D017886:Durapatite; D013752:Tetracycline