[Accumulation of Ca ions in intracellular structures of rat myometrium during subacute, acute, and chronic administration of ethanol].
The effects of subacute, acute and chronic ethanol exposure on the activity of Ca(2+)-accumulating systems of mitochondria and endoplasmic reticulum in myometrial cells of nonpregnant estrogen-treated rats were studied. It has been shown that the activity of Ca(2+)-accumulating system of mitochondria was higher than the activity of Ca(2+)-accumulating system of endoplasmic reticulum in myometrial cells from control, acute and subacute treated with ethanol rats. Under ethanol chronical assumption both Ca(2+)-accumulation in mitochondria and Ca(2+)-transporting activity of endoplasmic reticulum are inhibited. In the latter ease Mg2+, ATP-dependent Ca(2+)-pump lost its sensitivity to oxytocin.
Borisova
L A
LA
A. V. Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Babich
L G
LG
Shlykov
S G
SG
Kosterin
S  A
S
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D008928:Mitochondria / Q000378:metabolism; D009215:Myometrium / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D000431:Ethanol; D002118:Calcium
Akkumuliatsiia ionov Ca vo vnutrikletochnykh strukturakh mimetriia krys pri podostrom, ostrom i khronichskom vvedenii étanola.