Study on the correlation of plasma NO, ET-1 and ALT in the patients with chronic hepatitis and cirrhosis.
The levels of plasma nitric oxide (NO), endothelin-1 (ET-1) and ALT in the patients with chronic hepatitis B and active cirrhosis and the correlation among them were observed and analyzed. NO3- was restored by using cadmium column assay and NO2- measured by heavy nitrogen assay. The primitive NO3- and total restored NO2- (NO3-/NO2-) in plasma of the patients with chronic hepatitis and cirrhosis. Plasma ET-1 and ALT levels were determined by using radioimmunological assay and Lai's assay, respectively. Compared with normal control group, the plasma levels of NO2-/NO2- and ET-1 in the patients with chronic active hepatitis and active cirrhosis were significantly increased (P < 0.05-0.01). There was a positive correlation between NO and ALT, and ET-1 and ALT in the patients with chronic active hepatitis and active cirrhosis respectively. It was suggested that elevation of both NO and ET-1 levels were closely related with injury severity of liver function.
Tong
Q
Q
Department of Infectious Disease, Xiehe Hospital, Tongji Medical University, Wuhan 430030.
Zeng
L
L
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D019694:Hepatitis B, Chronic / Q000097:blood*; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000097:blood*
D019332:Endothelin-1; D009569:Nitric Oxide; D000410:Alanine Transaminase