A girl with severe fistulizing Crohn's disease.
We report the case of a girl with a severe perianal fistulizing Crohn's disease who during intravenous infusion of cyclosporine developed headache, general seizures and cortical blindness. Head magnetic resonance imaging showed spread, cortical-subcortical nonenhancing signal changes. Full neurological recovery was achieved in 24 hours. Cyclosporine was stopped and a single dose of infliximab was infused with rapid improvement of the fistula that at 7 months' follow-up is still closed.
Barabino
A
A
Paediatric Gastroenterology, G. Gaslini Institute for Children, Genoa, Italy. abarab@tin.it
Castellano
E
E
Gandullia
P
P
Biscaldi
E
E
D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D002648:Child; D003424:Crohn Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy*; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D007262:Infusions, Intravenous; D008279:Magnetic Resonance Imaging; D012003:Rectal Fistula / Q000150:complications / Q000175:diagnosis*; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000008:administration & dosage
D007166:Immunosuppressive Agents; D014409:Tumor Necrosis Factor-alpha; D016572:Cyclosporine