title: Addition of antibacterial agents to MMA-TBB dentin bonding systems--influence on tensile bond strength and antibacterial effect.
abstract: To produce a bonding system which has both high bond strength and antibacterial properties, an antibacterial agent (vancomycin: VCM or metronidazol: MN) was added to the PMMA powder of 4-META/MMA-TBB resin (CB). The influence of the addition of an antibacterial agent on tensile bond strength to dentin and the antibacterial effect were investigated in this study. Forty-seven freshly extracted bovine first or second incisors were used to measure the tensile bond strength to dentin. The bond strengths to bovine dentin were not significantly decreased by addition of VCM (1%, 2%, 5%), or MN (1%) to CB (p < 0.05). The antibacterial effect of CB containing antibacterial agent on six strains of bacteria was investigated by the agar plate diffusion method, analyzing the appearance of the inhibition zone around a resin disk following anaerobic culturing. The resin disks containing VCM showed antibacterial effects on all of the strains examined; the widths of the inhibition zones were 4-15 mm. The resin disks containing MN showed antibacterial effects on three strains; the widths of the inhibition zones were 0-4 mm. It was thus possible to produce a bonding system with both antibacterial effect and high tensile bond strength by addition of VCM to PMMA powder.
authors.affiliation: Department of Operative Dentistry and Endodontics, Iwate Medical University, Morioka, Iwate, 020-8505, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kudou
authors.forename: K
authors.initials: K
authors.lastname: Obara
authors.forename: T
authors.initials: T
authors.lastname: Kawashima
authors.forename: M
authors.initials: M
authors.lastname: Kubota
authors.forename: S
authors.initials: S
authors.lastname: Abe
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: M
authors.initials: M
authors.lastname: Komatsu
authors.forename: R
authors.initials: R
authors.lastname: Okuda
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D000190:Actinomyces / Q000187:drug effects; D016924:Actinomyces viscosus / Q000187:drug effects; D000704:Analysis of Variance; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001896:Boron Compounds / Q000737:chemistry / Q000494:pharmacology; D002417:Cattle; D003188:Composite Resins / Q000737:chemistry; D001840:Dental Bonding; D003799:Dental Stress Analysis / Q000295:instrumentation; D003804:Dentin / Q000648:ultrastructure; D017220:Dentin-Bonding Agents / Q000737:chemistry* / Q000494:pharmacology; D008689:Methacrylates / Q000737:chemistry / Q000494:pharmacology; D020366:Methylmethacrylate / Q000737:chemistry; D008768:Methylmethacrylates / Q000737:chemistry / Q000494:pharmacology; D008795:Metronidazole / Q000737:chemistry / Q000494:pharmacology; D019904:Polymethyl Methacrylate / Q000737:chemistry; D019279:Resin Cements / Q000737:chemistry / Q000494:pharmacology; D013291:Streptococcus / Q000187:drug effects; D013295:Streptococcus mutans / Q000187:drug effects; D013298:Streptococcus sanguis / Q000187:drug effects; D013718:Tensile Strength; D014640:Vancomycin / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000180:Acrylic Resins; D000900:Anti-Bacterial Agents; D001896:Boron Compounds; D003188:Composite Resins; D017220:Dentin-Bonding Agents; D008689:Methacrylates; D008768:Methylmethacrylates; D019279:Resin Cements; C009523:tri-n-butylborane; D008795:Metronidazole; D020366:Methylmethacrylate; D014640:Vancomycin; C031172:4-META resin; D019904:Polymethyl Methacrylate; C049495:Super-bond