A polymorphic microsatellite marker in the human p55 TNF receptor, CD120a.
We provide characterization of a highly polymorphic dinucleotide repeat in the human TNF-receptor 1 gene (TNFR1, TNFRp55, CD120a). We have observed 11 alleles at this locus in individuals from the West of Scotland. In a panel of healthy, unrelated individuals from the West of Scotland (n = 143), the overall heterozygosity was 68%, indicating the potential usefulness of these markers in immunogenetic studies.
Eskdale
J
J
University of Glasgow Department of Surgery, Queen Elizabeth Building, Glasgow Royal Infirmary, Glasgow G31 2ER, Scotland.
Turestkaya
R L
RL
Armstrong
C
C
Kuprash
D V
DV
Nedospasov
S A
SA
Gallagher
G
G
D000483:Alleles; D015703:Antigens, CD / Q000235:genetics*; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D018900:Dinucleotide Repeats; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*; D047888:Receptors, Tumor Necrosis Factor, Type I; D012606:Scotland
D015703:Antigens, CD; D017931:DNA Primers; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D004247:DNA