Linkage analysis of a candidate region in Scandinavian sib pairs with multiple sclerosis reveals linkage to chromosome 17q.
To date, four genome screens have been completed in the demyelinating autoimmune disease multiple sclerosis (MS). Although these screens failed to identify any loci with major effects on susceptibility, several novel regions of potential linkage were suggested, including the long arm of chromosome 17. In order to further pursue this promising region we have investigated six highly polymorphic microsatellite markers in 115 Scandinavian families with MS affected sib pairs. Multipoint linkage analysis revealed a peak maximum likelihood score (MLS) of 0.9 in the region of marker D17S787. Stratifying the results on the basis of HLA-DR2 status showed that the linkage was not limited to families segregating for the HLA-DR2 allele as has previously been suggested. In conclusion, our results further support the proposal that a multiple sclerosis susceptibility locus is contained on chromosome 17q.
Larsen
F
F
Department of Clinical Immunology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. flar@biobase.dk
Oturai
A
A
Ryder
L P
LP
Madsen
H O
HO
Hillert
J
J
Fredrikson
S
S
Sandberg-Wollheim
M
M
Laaksonen
M
M
Harbo
H F
HF
Sawcer
S
S
Fugger
L
L
Sorensen
P S
PS
Svejgaard
A
A
D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D015802:HLA-DR2 Antigen / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D009103:Multiple Sclerosis / Q000235:genetics* / Q000276:immunology; D012537:Scandinavian and Nordic Countries
D015802:HLA-DR2 Antigen