title: Adverse granulomatous reaction after cosmetic dermal silicone injection.
abstract: BACKGROUND
  Various alloplastic injectable implants have been developed for soft tissue augmentation without surgery, but different local or systemic adverse reactions have limited their use for cosmetic purposes.
  
  
  OBJECTIVE
  To examine the problems associated with silicone injection.
  
  
  METHODS
  Case report and literature review.
  
  
  RESULTS
  We describe an adverse granulomatous reaction after the injection of liquid silicone for lip augmentation, causing facial disfigurement. Although the initial response to steroids was poor, after 3 years of follow-up the nodules have almost disappeared spontaneously.
  
  
  CONCLUSIONS
  We advise that silicone injection be performed solely by trained physicians using medical-grade silicone or consider other injectable materials.
authors.affiliation: Department of Dermatology, Hospital Universitari Germans Trias i Pujol, Universitat Autònoma de Barcelona, Badalona, Spain.
authors.forename: X
authors.initials: X
authors.lastname: Bigatà
authors.forename: M
authors.initials: M
authors.lastname: Ribera
authors.forename: I
authors.initials: I
authors.lastname: Bielsa
authors.forename: C
authors.initials: C
authors.lastname: Ferrándiz
mesh_terms: D003357:Cosmetic Techniques / Q000009:adverse effects*; D020405:Dermis / Q000473:pathology; D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007279:Injections, Subcutaneous; D008046:Lip; D008875:Middle Aged; D012828:Silicones / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D012828:Silicones