[Biomodulation and radiotherapy].
Recent improvement in the understanding of the mechanisms involved in the response to ionizing radiation have made it possible to identify new therapeutic targets to increase the anti-tumor efficacy or, alternatively, to decrease the effect on normal tissues. These approaches included targeting genes involved in the regulation of radio-induced DNA-repair and cell death as well as genes involved in the regulation of radio-induced apoptosis. Many other molecular targets have been recently identified to potentially interfere with the response to ionizing radiation, such as some cell membrane growth factor receptors (EGFr, TGFb) or molecules involved in intra-cellular signal transduction pathways, cell cycle regulation, etc. In addition, other promising ways to modulate radiation-induced response concern extracellular or tissue factors such as hypoxia and angiogenesis.
Bourhis
J
J
Département de radiothérapie et unité propre de l'enseignement supérieur UPRES EA 27-10, institut Gustave-Roussy, 39, rue Camille-Desmoulins, 94805 Villejuif, France. bourhis@igr.fr
Lartigau
E
E
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000235:genetics*; D015687:Cell Hypoxia / Q000187:drug effects* / Q000502:physiology; D004260:DNA Repair; D006801:Humans; D009369:Neoplasms / Q000235:genetics / Q000503:physiopathology / Q000532:radiotherapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010100:Oxygen / Q000008:administration & dosage; D011836:Radiation Tolerance / Q000235:genetics*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D011853:Radiobiology; D014162:Transfection
D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents; D010100:Oxygen
Biomodulation et radiothérapie.