Mucormycosis resulting in a pseudoaneurysm in the spleen.
Mucormycosis is an uncommon and frequently fatal fungal infection. It characteristically affects patients with diabetes mellitus or patients with severe immunosuppression. The hallmark of mucormycosis infection is tissue infarction and vascular invasion. We present clinical data and imaging studies of a 16 year-old child with acute lymphoblastic leukemia complicated by disseminated mucormycosis resulting in a pseudoaneurysm of the spleen. This was successfully managed by a combination of systemic antifungal therapy (Amphotericin B) and surgery (splenectomy). This entity has not been described in the literature.
Nevitt
P C
PC
Medical College of Virginia, Virginia Commonwealth University, Department of Radiology, Richmond 23298-0615, USA.
Das Narla
L
L
Hingsbergen
E A
EA
D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D017541:Aneurysm, False / Q000382:microbiology* / Q000601:surgery; D000935:Antifungal Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications*; D009091:Mucormycosis / Q000150:complications* / Q000188:drug therapy; D013156:Splenectomy; D013158:Splenic Diseases / Q000382:microbiology* / Q000601:surgery
D000935:Antifungal Agents; D000666:Amphotericin B