Immunoglobulin subgroups in children with febrile seizures.
BACKGROUND
The aim of the present study was to determine whether or not there was a role for immunoglobulin (Ig) or IgG subgroups in the pathogenesis of febrile seizures (FS).


METHODS
Serum levels of IgA, total IgG, IgM, IgE, IgGI, IgG2, IgG3 and IgG4 were measured in 34 children with FS and in 37 healthy children used as a control group. Both patients and controls were divided into two groups according to age (group I, 6-24 months; group II, 25-72 months).


RESULTS
Compared with controls, mean IgG4 levels in patients were found to be decreased in both groups I and II (group I: 95 +/- 14 vs 57 +/- 5, respectively, P = 0.01; group II: 178.5 +/- 38.5 vs 65.1 +/- 24.5, respectively, P < 0.01), while mean IgG2 levels were found to be decreased only in group II patients (170 +/- 16 vs 103 +/- 22; P < 0.05).


CONCLUSIONS
The results of the present study suggest that Ig subclass deficiencies may be responsible for the infections connected with FS or that they may be related to the pathogenesis of FS in some children.
Caksen
H
H
Department of Pediatrics, Yüzüncü Yil University School of Medicine, Van, Turkey. huseyincaksen@hotmail.com
Oner
A F
AF
Arslan
S
S
Kan
M C
MC
Cesur
Y
Y
Uner
A
A
D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood / Q000145:classification*; D007223:Infant; D008297:Male; D003294:Seizures, Febrile / Q000276:immunology*
D007074:Immunoglobulin G