[Perspectives of post-genomic medical care in osteoporosis].
Osteoporosis is a multifactorial disease for which genetic and environmental factors are determinants. Recently, polymorphisms of many bone metabolism-related genes have been examined in the association study with bone mineral density and fracture incidence. Some showed significant correlation and others not. In addition, genome-wide QTL analysis was done using genome-wide random markers and showed some hot loci. However, the statistical power of each gene and locus are low and the genes to determine human bone mineral density have not been obtained. The accumulating information of genome science will help understand the pathogenesis of osteoporosis and find the useful ways for the prevention and the treatment of this disease.
Hosoi
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Endocrinology Section, Tokyo Metropolitan Geriatric Center.
D015519:Bone Density / Q000235:genetics; D015316:Genetic Therapy; D016045:Human Genome Project; D006801:Humans; D010024:Osteoporosis / Q000235:genetics; D011110:Polymorphism, Genetic