title: High frequency repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex in schizophrenic patients.
abstract: Repetitive transcranial magnetic stimulation (rTMS) has been tried therapeutically in major depression. In order to investigate the therapeutic efficacy of rTMS in psychotic patients, 12 participants (four women, eight men) with schizophrenia according to DSM-IV criteria, aged 25 to 63 years (mean (+/-s.d) 40.4+/-11.0), were enrolled in the study. Following a double-blind crossover design, patients were treated at random with 2 weeks of daily left prefrontal rTMS (20 2s 20 Hz stimulations at 80% motor threshold over 20 min, dorsolateral preforntal cortex) and 2 weeks of sham stimulation. The Brief Psychiatric Rating Scale decreased under active rTMS (p <0.05), whereas depressive symptoms (BDI) and anxiety (STAI) did not change significantly. Prefrontal rTMS might be effective in the non-pharmacological treatment of psychotic patients.
authors.affiliation: Department of Neurology and Clinical Neurophysiology, Medical School of Hannover, Germany.
authors.forename: J D
authors.initials: JD
authors.lastname: Rollnik
authors.forename: T J
authors.initials: TJ
authors.lastname: Huber
authors.forename: H
authors.initials: H
authors.lastname: Mogk
authors.forename: S
authors.initials: S
authors.lastname: Siggelkow
authors.forename: S
authors.initials: S
authors.lastname: Kropp
authors.forename: R
authors.initials: R
authors.lastname: Dengler
authors.forename: H M
authors.initials: HM
authors.lastname: Emrich
authors.forename: U
authors.initials: U
authors.lastname: Schneider
mesh_terms: D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D004599:Electric Stimulation Therapy / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D017397:Prefrontal Cortex / Q000473:pathology / Q000503:physiopathology*; D012559:Schizophrenia / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D012565:Schizophrenic Psychology; D050781:Transcranial Magnetic Stimulation / Q000627:therapeutic use*; D016896:Treatment Outcome