Role of pathways for signal transducers and activators of transcription, and mitogen-activated protein kinase in adipocyte differentiation.
Members of the signal transducer and activator of transcription (STAT) family and the mitogen-activated protein kinase (MAPK) cascade play a major role in the regulation of cell growth and differentiation. This review concentrates on the role played by these pathways in the development of adipose cells. STATs are activated by both positive and negative modulators of adipocyte differentiation leading to the hypothesis that the STAT pathway may function in adipogenesis. The role of the p42/p44 MAPK pathway in adipocyte differentiation has recently been the subject of contradictory reports. Several molecular mechanisms are proposed to explain the opposing effects of MAPK activation in the programme of adipose cell differentiation.
Aubert
J
J
Laboratoire de Biologie du Développement du Tissu Adipeux, Centre de Biochimie, UMR 6543 CNRS, Nice, France.
Belmonte
N
N
Dani
C
C
D017667:Adipocytes / Q000166:cytology* / Q000201:enzymology / Q000378:metabolism*; D000273:Adipose Tissue / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D000818:Animals; D002454:Cell Differentiation; D004268:DNA-Binding Proteins / Q000378:metabolism; D020935:MAP Kinase Signaling System; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D010940:Plant Proteins; D050794:STAT1 Transcription Factor; D015534:Trans-Activators / Q000378:metabolism / Q000502:physiology*
D004268:DNA-Binding Proteins; D010940:Plant Proteins; D050794:STAT1 Transcription Factor; D015534:Trans-Activators; C101691:MMK4 protein, Medicago sativa; D019950:Mitogen-Activated Protein Kinase 1; D020928:Mitogen-Activated Protein Kinases