title: Assessment of thyroid function in pesticide formulators.
abstract: Thirty male pesticide formulators exposed to the dust and liquid formulation of endosulfan, quinalphos, chlorpyriphos, monocrotophos, lindane, parathion, phorate, and fenvalerate and 20 comparable control subjects from the same area of study were examined for the evaluation of thyroid function tests. The level of TSH was elevated (about 28%) in pesticide formulators as compared to a control group, but the increase was statistically insignificant. Based on the individual TSH measurement, 3 of 30 formulators had isolated elevated levels of TSH and seem to have acquired sub-clinical hypothyroidism; five had TSH values slightly elevated to the upper boarder line (4.03 muIU/ml); and the majority of formulators (N= 22) had TSH values in the normal range varying from 1.29 to 3.9 muIU/ml. Total T3 was suppressed significantly (P< 0.01) in formulators, while marginal decrease (about 7%) was noticed in T4 level. This study indicated thyroid function impairment in few pesticide formulators.
authors.affiliation: National Institute of Occupational Health (Indian Council of Medical Research), Meghani Nagar, Ahmedabad.
authors.forename: S S
authors.initials: SS
authors.lastname: Zaidi
authors.forename: V K
authors.initials: VK
authors.lastname: Bhatnagar
authors.forename: S J
authors.initials: SJ
authors.lastname: Gandhi
authors.forename: M P
authors.initials: MP
authors.lastname: Shah
authors.forename: P K
authors.initials: PK
authors.lastname: Kulkarni
authors.forename: H N
authors.initials: HN
authors.lastname: Saiyed
mesh_terms: D000328:Adult; D002617:Chemical Industry; D006727:Hormone Antagonists / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000209:etiology*; D016273:Occupational Exposure; D010575:Pesticides / Q000009:adverse effects*; D011863:Radioimmunoassay; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D006727:Hormone Antagonists; D010575:Pesticides; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine