Suppression of harmaline-induced tremor in rats by vagus nerve stimulation.
We studied whether vagus nerve stimulation could suppress tremor in the harmaline tremor model in the rat. Animals were chronically implanted with helical leads around the left vagus nerve and a disk-shaped electrode positioned subcutaneously in the dorsal neck. Harmaline-induced tremor was recorded on a physiograph while each animal received a sequence of five 20-minute trials. Each trial consisted of five minutes of pre-stimulation baseline, five minutes of vagus nerve stimulation, and ten minutes of post-stimulation. Vagus nerve stimulation significantly suppressed harmaline-induced tremor. The suppressive effect was present within the first minute of stimulation and was reproducible across the five trials of the study. The results of this study suggest that the central generator or expression of tremor in the harmaline animal model can be suppressed by vagus nerve stimulation.
Handforth
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Neurology Service, VA Greater Los Angeles Healthcare System, West Los Angeles Healthcare Center, California 90073, USA.
Krahl
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D000818:Animals; D000697:Central Nervous System Stimulants; D004195:Disease Models, Animal; D004558:Electric Stimulation / Q000379:methods; D006246:Harmaline; D008297:Male; D051381:Rats; D020318:Rats, Long-Evans; D014202:Tremor / Q000139:chemically induced / Q000628:therapy*; D014630:Vagus Nerve / Q000502:physiology*
D000697:Central Nervous System Stimulants; D006246:Harmaline