Phosphodiesterase 4 isoenzyme inhibitory activity of 3-phenylxanthines and 4-pheny.
On the basis of our study on the structure-activity relationships of 1,3,7-alkylxanthines and condensed-purines on cAMP-phosphodiesterase 4 (PDE 4) isoenzyme inhibitor, we investigated the synthesis and the inhibitory activity of 3-phenylxanthine and 4-phenyl[i]condensed-purine derivatives. Xanthines and condensed-purines with the phenyl group exhibited potent and selective PDE 4 inhibitory activity.
Suzuki
H
H
Department of Synthetic Chemistry, Faculty of Pharmaceutical Science, Hokuriku University, Kanazawa, Japan. h-suzuki@hokuriku-u.ac.jp
Sawanishi
H
H
Yamamoto
K
K
Yokogawa
K
K
Miyamoto
K
K
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D000818:Animals; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006168:Guinea Pigs; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011687:Purines / Q000737:chemistry / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D014970:Xanthines / Q000737:chemistry / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D011687:Purines; D014970:Xanthines; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4