The synthesis of deuterionucleosides.
The synthesis of deuterionucleosides for site-specific incorporation into oligo-DNA or -RAA is herein reviewed for NMR or biological studies. The review covers the following aspects: (i) deuteration of the aglycone; (ii) single-site chemical deuteration of the sugar residues; (iii) multiple-site chemical deuteration of the sugar residues; (iv) enzymatic synthesis of deuterated nucleosides or nucleotides; and (v) synthesis of labelled nucleosides with multiple isotopes
Földesi
A
A
Department of Bioorganic Chemistry, Biomedical Center, University of Uppsala, Sweden. andras@bioorgchem.uu.se
Trifonova
A
A
Kundu
M K
MK
Chattopadhyaya
J
J
D003903:Deuterium / Q000737:chemistry*; D009705:Nucleosides / Q000138:chemical synthesis* / Q000737:chemistry
D009705:Nucleosides; D003903:Deuterium