[Effect of hydrocortisone on purine actions in the nerve-muscle preparation].
Daily administration of hydrocortisone first increased and then decreased amplitude of multiquantal end-plate currents induced by motor nerve stimulation. The initial facilitating phase of the hormone action was accompanied by elimination of the ATP pre-synaptic effect. Later the inhibitory effect of the ATP becomes restored. The counteraction of the ATP effect was reproduced in the isolated muscle bathed in the saline with hydrocortisone which suggests a non-genomic action of the hormone on pre-synaptic P2 receptor. The data obtained suggest that prevention of the ATP inhibitory action might be a component of a facilitating acute stress reaction.
Giniatullin
A R
AR
Medical University, 420012, Kazan, Butlerov St., 49, Russia.
Grishin
S N
SN
Giniatullin
R A
RA
D000241:Adenosine / Q000494:pharmacology* / Q000502:physiology; D000255:Adenosine Triphosphate / Q000494:pharmacology* / Q000502:physiology; D000818:Animals; D006854:Hydrocortisone / Q000494:pharmacology* / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials; D009045:Motor Endplate / Q000187:drug effects / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000502:physiology; D011895:Rana ridibunda; D012584:Sciatic Nerve / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology
D000255:Adenosine Triphosphate; D000241:Adenosine; D006854:Hydrocortisone
Vliianie gidrokortizona na moduliruiushchie éffekty purinov v nervno-myshechnom soedinenii.