A case of haemophagocytic syndrome and Kikuchi-Fujimoto disease occurring concurrently in a 17-year-old female.
An unusual case in which a young Asian female presenting with fever, lymphadenopathy and cytopaenia was found to have distinct histological features of both haemophagocytic syndrome (HS) and histiocytic necrotising lymphadenitis (Kikuchi-Fujimoto disease, KFD) is presented. We review the clinical features of each of these rare, but important, diagnoses and propose the hypothesis that they may form part of a disease continuum, rather than representing separate entities.
Kelly
J
J
Department of Geriatrics and GIM, Queen Mary's Hospital, Sidcup, UK.
Kelleher
K
K
Khan
M K
MK
Rassam
S M
SM
D000293:Adolescent; D001706:Biopsy; D001854:Bone Marrow Cells / Q000473:pathology; D018450:Disease Progression; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications* / Q000175:diagnosis; D015616:Histiocytosis, Non-Langerhans-Cell / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology