title: [Acute retinal necrosis syndrome: analysis, therapy and long-term follow up of 14 eyes].
abstract: OBJECTIVE
  Acute retinal necrosis syndrome (ARN) might be complicated by retinal detachment, vasculopathy and optic neuropathy and has a poor prognosis despite intensive medical and surgical therapy.
  
  
  METHODS
  A series of 10 consecutive patients (14 eyes) with ARN were followed for 36 months (average of 20 months +/- 10). We present the results of the clinical evaluation for diagnostic and therapeutic modalities.
  
  
  RESULTS
  Viral etiology was confirmed in 9 of 10 aqueous-humor samples. Intraocular antibody synthesis against Varicella-Zoster Virus was found in 7, against Herpes-Simplex Virus in 5 and against Cytomegalovirus in 2 samples. Three eyes had a mild clinical course with a visual acuity of 0.6 or better. Vitrectomy and silicone-oil tamponade preserved visual acuity from 0.3 to 0.1. ARN lead to blindness in 5 eyes due to vasculopathy, optic neuropathy or retinal detachment. An arterial branch occlusion was successfully overcome with i.v. heparin treatment in one patient.
  
  
  CONCLUSIONS
  Aqueous-humor analysis supports clinical diagnosis. Early vitrectomy and silicone oil tamponade stabilizes retinal structure and preserves visual acuity. Occlusive vasculopathy and optic neuropathy are the main causes leading to blindness.
authors.affiliation: Augenklinik, Charité Campus Virchow-Klinikum, Humboldt-Universität zu Berlin, Augustenburger Platz 1, Berlin.
authors.forename: B
authors.initials: B
authors.lastname: Müller
authors.forename: K H
authors.initials: KH
authors.lastname: Velhagen
authors.forename: U
authors.initials: U
authors.lastname: Pleyer
mesh_terms: D000212:Acyclovir / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use*; D001082:Aqueous Humor / Q000821:virology; D003587:Cytomegalovirus / Q000302:isolation & purification*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D015774:Ganciclovir / Q000627:therapeutic use; D018259:Herpesvirus 1, Human / Q000302:isolation & purification*; D014645:Herpesvirus 3, Human / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures / Q000379:methods*; D011446:Prospective Studies; D015882:Retinal Necrosis Syndrome, Acute / Q000503:physiopathology / Q000628:therapy* / Q000821:virology*; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D015774:Ganciclovir; D000212:Acyclovir
vernacular_title: Akute Retinanekrose: Analyse, Therapie und Langzeitbeobachtung an 14 Augen.