Contribution of sodium valproate to the syndrome of inappropriate secretion of antidiuretic hormone.
We report the case of a 62-year-old man who was administered sodium valproate (VPA) and who subsequently developed the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). He had been taking VPA for treatment of idiopathic generalized tonic-clonic convulsions since he was 56 years old. After substituting VPA with zonisamide, the serum sodium level returned to normal. We consider this episode of SIADH to be the result of a combination of factors including a weakness of the central nervous system and the long-term administration of VPA.
Miyaoka
T
T
Department of Psychiatry, Shimane Medical University, Japan.
Seno
H
H
Itoga
M
M
Kishi
T
T
Ishino
H
H
Horiguchi
J
J
D003937:Diagnosis, Differential; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy*; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced / Q000175:diagnosis; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014635:Valproic Acid / Q000009:adverse effects* / Q000627:therapeutic use
D014635:Valproic Acid