Coupling of simulated moving bed chromatography and fractional crystallisation for efficient enantioseparation.
An optimised coupling of liquid chromatography and fractional crystallisation is suggested for efficient enantioseparation. As a first stage, a chromatographic separation, preferably simulated moving bed (SMB) chromatography, is applied to achieve an enantiomeric enrichment sufficient for a subsequent crystallisation. First results of the experimental and modelling work for the model system (+)-/(-)-mandelic acid in an aqueous solution are described. Chromatographic investigations involve the estimation of adsorption isotherms on a suitable chiral stationary phase and the simulation and optimisation of a corresponding SMB process. From the ternary phase diagram measured for the (+)-/(-)-enantiomer/ solvent system, the conditions required to crystallise a pure enantiomer from an asymmetric mixture can be derived. The productivity gains achievable from the combined process compared to the application of chromatography alone are discussed.
Lorenz
H
H
Max für Dynamik komplexer technischer Systeme, Magdeburg, Germany.
Sheehan
P
P
Seidel-Morgenstern
A
A
D002853:Chromatography, Liquid / Q000379:methods*; D003460:Crystallization; D008333:Mandelic Acids / Q000737:chemistry / Q000302:isolation & purification; D013237:Stereoisomerism
D008333:Mandelic Acids; C037938:mandelic acid