[Biosynthesis of the non-polyene antibiotic imbricin in the medium containing the producer culture filtrate].
Imbricin (macrolide nonpolyen antibiotic) biosynthesis conditions was investigated in the medium containing culture filtrate of its producer--Streptomyces imbricatus. It was demonstrated that filtrate contains some regulator substance affecting the antibiotic biosynthesis and metabolism processes of actinomycetes S. imbricatus. Maximum of regulator accumulation coincides with maximum of antibiotic biosynthesis, and amount of synthesized imbricin is proportional to the amount of the culture filtrate added to the medium. When low active mutant of S. imbricatus was grown in the medium with added regulator its activity achieved the control level. It was shown that stimulating activity of the producer's culture filtrate is not connected with pH changes or with supplement with some additional nutritional substrates.
Topkova
O V
OV
St. Petersburg State Chemo-Pharmaceutical Academy.
Iaskovich
G A
GA
Iakovleva
E P
EP
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D003470:Culture Media; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D003470:Culture Media
Izuchenie biosinteza nepolienovogo antibiotika imbritsina na srede, soderzhashcheĭ fil'trat kul'tural'noĭ zhidkosti produtsenta.