Smooth muscle tumor developing in an immunocompromised child after therapy for leukemia.
We report a 5.5-year-old boy who underwent autologous peripheral blood stem cell transplantation for high-risk acute lymphoblastic leukemia and who had two abdominal masses develop 6 months later. Macroscopically complete resection of the abdominal tumors was performed and revealed a well-differentiated leiomyosarcoma. Smooth muscle tumors, benign or malignant, are increasingly recognized in children with various immunodeficiencies; the association with acute lymphoblastic leukemia is rarely described.
Brichard
B
B
Department of Pediatric Hematology/Oncology, University of Louvain, Brussels, Belgium.
Vermylen
C
C
Gosseye
S
S
Otte
J B
JB
Cornu
G
G
D000008:Abdominal Neoplasms / Q000209:etiology* / Q000601:surgery; D018943:Anthracyclines / Q000008:administration & dosage / Q000009:adverse effects*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D001215:Asparaginase / Q000008:administration & dosage / Q000009:adverse effects*; D002675:Child, Preschool; D003348:Cortisone / Q000008:administration & dosage / Q000009:adverse effects*; D004198:Disease Susceptibility; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016867:Immunocompromised Host; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced / Q000150:complications* / Q000209:etiology; D007890:Leiomyosarcoma / Q000209:etiology* / Q000601:surgery; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000188:drug therapy* / Q000628:therapy; D015122:Mercaptopurine / Q000008:administration & dosage / Q000009:adverse effects; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000601:surgery; D012074:Remission Induction; D019172:Transplantation Conditioning / Q000009:adverse effects*; D014182:Transplantation, Autologous; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects*; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D018943:Anthracyclines; D014750:Vincristine; D015122:Mercaptopurine; D001215:Asparaginase; D003348:Cortisone