DNA repair effect of traditional sweet pepper Fushimi-togarashi: seen in suppression of UV-induced cyclobutane pyrimidine dimer in human fibroblast.
The aqueous fraction of Fushimi sweet pepper increased the repair effect of the solvent control against UV-induced cyclobutane pyrimidine dimers in human fibroblast to 150%, but ordinary sweet pepper did not have a statistically significant effect. When Fushimi sweet pepper was boiled, the activity of the aqueous fraction was elevated to 209% of the control (p<0.05), while that of the grilled state was decreased to 125% of the control. The repair activity of a dialyzate (MW<12,000) of the aqueous fraction from Fushimi sweet pepper showed 191% of the control (p<0.05). The dialyzate was contained 1.9% in the weight of the fresh fruit body of Fushimi sweet pepper, and the activity can be stable in its boiling state, and it might be therefore considered to be the worthy source for expecting the DNA repair activity in human diet.
Nakamura
Y
Y
Department of Food Sciences and Nutritional Health, Kyoto Prefectural University, Japan.
Tomokane
I
I
Mori
T
T
Tanaka
A
A
Koutani
J
J
Matsuo
T
T
Okamoto
S
S
Sato
K
K
Ohtsuki
K
K
D016587:Antimutagenic Agents / Q000494:pharmacology; D002212:Capsicum / Q000737:chemistry*; D002478:Cells, Cultured; D004260:DNA Repair / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects / Q000528:radiation effects; D005511:Food Handling / Q000379:methods; D006801:Humans; D007564:Japan; D008970:Molecular Weight; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal; D011740:Pyrimidine Dimers / Q000528:radiation effects*; D014466:Ultraviolet Rays
D016587:Antimutagenic Agents; D010936:Plant Extracts; D011740:Pyrimidine Dimers