[Effect of selenium on serum, hepatic and lipoprotein lipids concentration in rats fed on a high-cholesterol diet].
The effects of Selenium (Se) on lipid metabolism was studied in male Wistar rats which were fed a high-cholesterol diet (HCD) containing 1%(w/w) cholesterol and 0.5%(w/w) cholic acid for 10 weeks. Se was orally administered at daily doses of 0.173 mg/kg in HCD into the test rats for 10 weeks. As compared with control groups, Se/HCD suppressed the amounts of triglyceride (TG), total cholesterol (CH) and free fatty acid in the serum. Se/HCD also decreased the amounts of low-density lipoprotein cholesterol (LDL-C) in the serum. Further-more, Se/HCD inhibited the amount of liver TG and CH. The activity of fatty acid synthetase in the HCD fed group was higher than in the Se/HCD fed group. These results suggest that Se may have recuperative effects for hypercholesterolemia.
Iizuka
Y
Y
Department of Pharmaceutics I, Tohoku Pharmaceutical University, 4-4-1, Komatsushima, Aoba-ku, Sendai 981-8558, Japan.
Sakurai
E
E
Tanaka
Y
Y
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D008078:Cholesterol, LDL / Q000378:metabolism; D064429:Fatty Acid Synthases / Q000378:metabolism; D006937:Hypercholesterolemia / Q000188:drug therapy; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology* / Q000627:therapeutic use; D014280:Triglycerides / Q000378:metabolism
D002791:Cholesterol, Dietary; D008078:Cholesterol, LDL; D014280:Triglycerides; D064429:Fatty Acid Synthases; D000103:Acetyl-CoA Carboxylase; D012643:Selenium