title: Cocaine catalytic antibodies: the primary importance of linker effects.
abstract: Current treatments for cocaine addiction are not effective. The development of a catalytic monoclonal antibody (mAb) provides a strategy for not only binding, but also degrading cocaine, which offers a broad-based therapy. Hapten design is the central element for programming antibody catalysis. The characteristics of the linker used in classic transition-state analogue phosphonate haptens were shown to be important for obtaining mAbs that hydrolyze the benzoate ester of cocaine.
authors.affiliation: The Scripps Research Institute and the Skaggs Institute for Chemical Biology, Department of Chemistry, La Jolla, CA 92037, USA.
authors.forename: M
authors.initials: M
authors.lastname: Matsushita
authors.forename: T Z
authors.initials: TZ
authors.lastname: Hoffman
authors.forename: J A
authors.initials: JA
authors.lastname: Ashley
authors.forename: B
authors.initials: B
authors.lastname: Zhou
authors.forename: P
authors.initials: P
authors.lastname: Wirsching
authors.forename: K D
authors.initials: KD
authors.lastname: Janda
mesh_terms: D000818:Animals; D017151:Antibodies, Catalytic / Q000378:metabolism* / Q000627:therapeutic use; D000911:Antibodies, Monoclonal / Q000378:metabolism / Q000627:therapeutic use; D003042:Cocaine / Q000276:immunology* / Q000378:metabolism; D019970:Cocaine-Related Disorders / Q000188:drug therapy; D015195:Drug Design; D006241:Haptens / Q000737:chemistry; D006868:Hydrolysis; D007700:Kinetics; D051379:Mice; D063065:Organophosphonates / Q000737:chemistry; D013329:Structure-Activity Relationship
chemical_list: D017151:Antibodies, Catalytic; D000911:Antibodies, Monoclonal; D006241:Haptens; D063065:Organophosphonates; D003042:Cocaine