Inhibition of neutrophil elastase activity by cinnamic acid derivatives from Cimicifuga racemosa.
Caffeic acid, fukinolic acid as well as cimicifugic acids A, B, E and F isolated from the rhizomes of Cimicifuga racemosa (Ranunculaceae) inhibited the activity of neutrophil elastase (EC 3.4.21.37) in a dose-dependent manner. An IC50 of 93 mumol/L was determined for caffeic acid and 0.23 mumol/L for fukinolic acid. Cimicifugic acid A inhibited the enzyme with an IC50 of 2.2 mumol/L, cimicifugic acid B with 11.4 mumol/L, and cimicifugic acid F with 18 mumol/L. Cimicifugic acid E was only a very weak inhibitor.
Löser
B
B
Kruse
S O
SO
Melzig
M F
MF
Nahrstedt
A
A
D002934:Cinnamates / Q000737:chemistry / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D019684:Magnoliopsida / Q000737:chemistry*
D002934:Cinnamates; D004791:Enzyme Inhibitors; C029010:cinnamic acid; D019272:Leukocyte Elastase