Genetic and environmental influences on alcohol metabolism in humans.
This manuscript represents the proceedings of a symposium at the 2000 RSA Meeting in Denver, Colorado. The organizer/chair was Ting-Kai Li. The presentations were: (1) Introduction to the Symposium, by Ting-Kai Li; (2) ALDH2 polymorphism and alcohol metabolism, by Shih-Jiun Yin; (3) ALDH2 promoter polymorphism and alcohol metabolism, by David W. Crabb; (4) Use of BrAC clamping to estimate alcohol elimination rates: Application to studies of the influence of genetic and environmental determinants, by Sean O'Connor; and (5) Effect of food and food composition on alcohol elimination rates as determined by clamping, by Vijay A. Ramchandani.
Li
T K
TK
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA. tkli@iupui.edu
Yin
S J
SJ
Crabb
D W
DW
O'Connor
S
S
Ramchandani
V A
VA
D000426:Alcohol Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D000428:Alcohol Drinking / Q000235:genetics* / Q000378:metabolism; D000437:Alcoholism / Q000235:genetics* / Q000378:metabolism; D000444:Aldehyde Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D002492:Central Nervous System Depressants / Q000378:metabolism* / Q000494:pharmacology; D004032:Diet; D004777:Environment; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology; D005502:Food; D005838:Genotype; D006439:Hemodynamics / Q000187:drug effects / Q000235:genetics; D006801:Humans; D011110:Polymorphism, Genetic
D002492:Central Nervous System Depressants; D000431:Ethanol; D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial