title: The identification of alpha-ketoamides as potent inhibitors of hepatitis C virus NS3-4A proteinase.
abstract: Peptides based upon the non-prime side residues of the NS4A-4B cleavage site of hepatitis C virus (HCV) NS3-4A proteinase containing an alpha-ketoamide moiety in place of the scissile amide bond are potent inhibitors of this enzyme.
authors.affiliation: Department of Chemistry, Roche Discover Welwyn, Welwyn Garden City, Hertfordshire, UK.
authors.forename: J M
authors.initials: JM
authors.lastname: Bennett
authors.forename: A D
authors.initials: AD
authors.lastname: Campbell
authors.forename: A J
authors.initials: AJ
authors.lastname: Campbell
authors.forename: M G
authors.initials: MG
authors.lastname: Carr
authors.forename: R M
authors.initials: RM
authors.lastname: Dunsdon
authors.forename: J R
authors.initials: JR
authors.lastname: Greening
authors.forename: D N
authors.initials: DN
authors.lastname: Hurst
authors.forename: N S
authors.initials: NS
authors.lastname: Jennings
authors.forename: P S
authors.initials: PS
authors.lastname: Jones
authors.forename: S
authors.initials: S
authors.lastname: Jordan
authors.forename: P B
authors.initials: PB
authors.lastname: Kay
authors.forename: M A
authors.initials: MA
authors.lastname: O'Brien
authors.forename: J
authors.initials: J
authors.lastname: King-Underwood
authors.forename: T M
authors.initials: TM
authors.lastname: Raynham
authors.forename: C S
authors.initials: CS
authors.lastname: Wilkinson
authors.forename: T C
authors.initials: TC
authors.lastname: Wilkinson
authors.forename: F X
authors.initials: FX
authors.lastname: Wilson
mesh_terms: D000577:Amides / Q000494:pharmacology; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D006801:Humans; D020128:Inhibitory Concentration 50; D018716:Molecular Mimicry; D010455:Peptides / Q000138:chemical synthesis / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D017361:Viral Nonstructural Proteins / Q000037:antagonists & inhibitors*
chemical_list: D000577:Amides; D000998:Antiviral Agents; C093542:NS4 protein, hepatitis C virus; D010455:Peptides; D015842:Serine Proteinase Inhibitors; D017361:Viral Nonstructural Proteins