Industrial scale-up of countercurrent chromatography: predictive scale-up.
This study describes how scale-up in countercurrent chromatography (CCC) can be simply predicted on a process scale CCC device by running a preliminary analytical-sized sample and having knowledge of the stationary-phase retention at scale-up conditions. Results have shown that simple experimentation can lead within a day to a process with the capability of several kilograms per day (tons per year) compound yield, and that this is feasible with benchtop CCC units.
Sutherland
I A
IA
Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex, UK.
Brown
L
L
Graham
A S
AS
Guillon
G G
GG
Hawes
D
D
Janaway
L
L
Whiteside
R
R
Wood
P
P