title: A highly polymorphic CA repeat marker at the interleukin-11 locus.
abstract: The interleukin-11 (IL-11) stimulates T cell-dependent development of immunoglobulin-producing B cells and collaborates with IL-3 in supporting murine megakaryocyte colony formation. The interleukin-11 (IL-11) also stimulates osteoclast formation and inhibits osteoclast function in vitro and has been implicated in estrogen deficiency-induced bone loss. We isolated a polymorphic dinucleotide (CA) repeat sequence from a genomic clone containing the IL-11 gene located at 19q13.3-q13.4. High heterozygosity (0.81) makes this polymorphism a useful marker in genetic study of disorders affecting immune response and bone metabolism.
authors.affiliation: Department of Molecular Biology, Institute of Gerontology, Nippon Medical School, 1-396, Kosugi-cho, Nakahara-ku, Kawasaki 211-8533, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ota
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Shirai
authors.forename: M
authors.initials: M
authors.lastname: Emi
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D004247:DNA / Q000032:analysis; D018900:Dinucleotide Repeats / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D007109:Immunity / Q000235:genetics; D017370:Interleukin-11 / Q000235:genetics*; D008969:Molecular Sequence Data; D010022:Osteopetrosis / Q000235:genetics; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic
chemical_list: D017370:Interleukin-11; D004247:DNA