title: Genetic manipulation of sex differentiation and phenotype in domestic animals.
abstract: In mammals, a gene based sex determination system ensures that approximately 50% of offspring will be of the male sex and 50% will be of the female sex. In domestic animal production systems, this ratio is not always ideal. Recent advances in our understanding of the molecular biology of sex determination and differentiation, as well as in the control of gene expression and the direct modification of animal genomes, allows us to consider methods for the direct genetic manipulation of sexual phenotype.
authors.affiliation: Centre de recherche en reproduction animale (CRRA), Faculty of Veterinary Medicine, University of Montréal, St. Hyacinthe Québec, Canada J2S 7C6. silverdw@medvet.umontral.ca
authors.forename: D W
authors.initials: DW
authors.lastname: Silversides
authors.forename: N
authors.initials: N
authors.lastname: Pilon
authors.forename: R
authors.initials: R
authors.lastname: Behdjani
authors.forename: A
authors.initials: A
authors.lastname: Boyer
authors.forename: I
authors.initials: I
authors.lastname: Daneau
authors.forename: J
authors.initials: J
authors.lastname: Lussier
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000235:genetics*; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D005821:Genetic Techniques; D008297:Male; D009687:Nuclear Proteins; D010641:Phenotype; D012098:Reproduction; D019849:Sex Determination Processes; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors
chemical_list: D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors