title: Serum zinc, copper and magnesium in sickle cell disease at Ibadan, south western Nigeria.
abstract: Serum zinc, copper and magnesium were studied in patients with sickle cell disease in the steady state. There was significantly lower serum zinc concentration (P < 0.01) and significantly higher serum copper and magnesium in haemoglobin S patients compared with controls (HbA). In haemoglobin SC patients, there was a significant reduction in serum zinc (P < 0.01) but no significant difference in serum copper and magnesium concentrations compared with the controls. There was no significant difference in serum zinc concentration between the HbS and HbS + C patients. However there were significantly higher serum copper and magnesium in HbS than HbS + C patients (P < 0.01) The level of serum zinc has no correlation with the steady state Haematocrit or severity index score in HbS and HbS + C patients.
authors.affiliation: Department of Chemical Pathology, University College Hospital, Ibadan, Nigeria.
authors.forename: F O
authors.initials: FO
authors.lastname: Akenami
authors.forename: Y A
authors.initials: YA
authors.lastname: Aken'Ova
authors.forename: B O
authors.initials: BO
authors.lastname: Osifo
mesh_terms: D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000145:classification / Q000150:complications / Q000628:therapy; D001803:Blood Transfusion; D016022:Case-Control Studies; D003300:Copper / Q000097:blood*; D006400:Hematocrit; D006450:Hemoglobin SC Disease / Q000097:blood* / Q000145:classification / Q000150:complications / Q000628:therapy; D006801:Humans; D008274:Magnesium / Q000097:blood*; D009549:Nigeria; D010146:Pain / Q000209:etiology; D012720:Severity of Illness Index; D014505:Urban Population; D015032:Zinc / Q000097:blood* / Q000172:deficiency
chemical_list: D003300:Copper; D008274:Magnesium; D015032:Zinc