title: The polymorphism at position  -174 of the IL-6 gene is not associated with inflammatory bowel disease.
abstract: OBJECTIVE
  Inflammatory bowel diseases (IBD) are multifactorial disorders, characterized by failure to limit the inflammatory response to luminal antigens. Genetic factors play an important role in the pathogenesis, but little is known about the accountable genes. Increased secretion of pro-inflammatory cytokines appears crucial in the initiation of the inflammatory response.
  
  
  METHODS
  To evaluate the role of the IL-6 gene in IBD, a functionally relevant polymorphism in the promoter region (G/C at position -174) has been genotyped in 169 patients with Crohn's disease (CD), 133 patients with ulcerative colitis (UC) and 440 healthy controls by using restriction fragment length polymorphism (RFLP) analysis.
  
  
  RESULTS
  No significant differences were apparent in the allele, genotype and carrier frequencies between patients and controls.
  
  
  CONCLUSIONS
  High secretion of IL-6 does not seem to play a major role in the genetic predisposition to IBD.
authors.affiliation: Abteilung fuer Molekulare Humangenetik, Ruhr-Universitaet, Bochum, Germany. wolfram.klein@ruhr-uni-bochum.de
authors.forename: W
authors.initials: W
authors.lastname: Klein
authors.forename: A
authors.initials: A
authors.lastname: Tromm
authors.forename: T
authors.initials: T
authors.lastname: Griga
authors.forename: H
authors.initials: H
authors.lastname: Fricke
authors.forename: C
authors.initials: C
authors.lastname: Folwaczny
authors.forename: M
authors.initials: M
authors.lastname: Hocke
authors.forename: K
authors.initials: K
authors.lastname: Eitner
authors.forename: M
authors.initials: M
authors.lastname: Marx
authors.forename: J T
authors.initials: JT
authors.lastname: Epplen
mesh_terms: D000483:Alleles; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D015850:Interleukin-6 / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D015850:Interleukin-6