title: Treatment of chronic hypertension with intravenous enalaprilat and transdermal clonidine.
abstract: We report an 11-year-old boy with hypertension and chronic intestinal pseudo-obstruction, which renders him totally dependent on parenteral nutrition and prevents the use of oral medications. Here we report the feasibility of utilizing chronic i.v. enalaprilat and transdermal clonidine on a chronic basis to control hypertension. Over the last 10 months, the patient's hypertension has been well controlled by 1.25 mg i.v. enalaprilat every 8 h and a 0.2-mg clonidine patch every 6 days, with no apparent side-effects. There are no reports of i.v. enalaprilat usage exceeding 3 weeks' duration. Therefore we believe that it is possible to effect reasonable management of chronic hypertension with the use of chronic i.v. enalaprilat and transdermal clonidine therapy.
authors.affiliation: Section of Pediatric Nephrology, Arizona Health Sciences Center, University of Arizona, 1501, N. Campbell Avenue, P.O. Box 245073, Tucson, AZ 85724, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Zawaideh
authors.forename: B
authors.initials: B
authors.lastname: Duncan
authors.forename: M W
authors.initials: MW
authors.lastname: Joseph
authors.forename: M P
authors.initials: MP
authors.lastname: Dixit
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002908:Chronic Disease; D003000:Clonidine / Q000008:administration & dosage* / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D015773:Enalaprilat / Q000008:administration & dosage* / Q000627:therapeutic use; D005240:Feasibility Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007275:Injections, Intravenous; D007418:Intestinal Pseudo-Obstruction / Q000150:complications / Q000628:therapy; D008297:Male; D010288:Parenteral Nutrition
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D015773:Enalaprilat; D003000:Clonidine