title: IL-1, IL-4 production and IgE levels in acute and chronic fasciolosis before and after triclabendazole treatment.
abstract: IL-1 generation by mononuclear phagocytes, IL-4 production by Th2 lymphocytes and IgE levels in serum were measured in eight patients with acute fasciolosis and seven patients in the chronic stage of the disease before and after triclabendazole treatment. Results were compared with those of a control group of ten individuals. The monocytes and lymphocytes from patients with acute and chronic fasciolosis produced significantly lower levels of IL-1 and IL-4 respectively, particularly in the chronic phase of the disease, as compared to the control. A significant increase in IgE level in both acute and chronic fasciolosis was observed. The level was significantly higher in acute as compared to chronic cases. After treatment with triclabendazole IL-1, IL-4 and IgE levels moved towards the control indicating obvious improvement in the immunological responses of the patients.
authors.affiliation: Department of Parasitology, Medical Research Institute, Alexandria University, Egypt.
authors.forename: A F
authors.initials: AF
authors.lastname: Allam
authors.forename: M M
authors.initials: MM
authors.lastname: Osman
authors.forename: M H
authors.initials: MH
authors.lastname: el-Sayed
authors.forename: S R
authors.initials: SR
authors.lastname: Demian
mesh_terms: D000293:Adolescent; D000328:Adult; D000871:Anthelmintics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D005211:Fascioliasis / Q000188:drug therapy / Q000378:metabolism*; D006801:Humans; D007073:Immunoglobulin E / Q000378:metabolism*; D007375:Interleukin-1 / Q000096:biosynthesis*; D015847:Interleukin-4 / Q000096:biosynthesis*; D008214:Lymphocytes / Q000378:metabolism; D008875:Middle Aged; D010586:Phagocytes / Q000378:metabolism; D000077682:Triclabendazole
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D007375:Interleukin-1; D015847:Interleukin-4; D007073:Immunoglobulin E; D000077682:Triclabendazole