title: [Irritating effect and dermal toxicity of virkon, a disinfectant widely used in Poland].
abstract: The aim of the study was to define the threshold irritating effect of Virkon, a disinfectant widely used in Poland, on the rabbit's skin and eye, and its dermal toxicity in single exposure. The studies were carried out according to the OECD guidelines, modified by Krysiak. A 10% aqueous solution of Virkon in the conditions of multiple open exposure was defined as the threshold concentration evoking small inflammatory reaction. After a single administration of Virkon in aqueous solutions into the rabbit's eye, the value of sensitising effect index was 1.5 for 1% solution of the disinfectant in question which indicates weak inflammatory reaction. The study of dermal toxicity in a single exposure revealed neither animal death nor morphological changes in internal organs which suggests non-cutaneous absorption of Virkon. The present study may provide the basis for assessing dermatological changes in people exposed to disinfectants.
authors.affiliation: Zakładu Toksykologii i Kancerogenezy, Instytut Medycyny Pracy im. prof. dra med. Jerzego Nofera w Łodzi.
authors.forename: B
authors.initials: B
authors.lastname: Krysiak
authors.forename: J
authors.initials: J
authors.lastname: Stetkiewicz
authors.forename: M
authors.initials: M
authors.lastname: Kieć-Swierczyńska
mesh_terms: D000818:Animals; D017453:Dermatitis, Irritant / Q000209:etiology; D004202:Disinfectants / Q000633:toxicity*; D005123:Eye / Q000187:drug effects*; D010545:Peroxides / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects*; D013464:Sulfuric Acids / Q000633:toxicity*; D014605:Uveitis / Q000139:chemically induced
chemical_list: D004202:Disinfectants; D010545:Peroxides; D013464:Sulfuric Acids; C071517:monoperoxysulfate
vernacular_title: Ocena działania drazniacego i toksyczności dermalnej Virkonu, preparatu dezynfekujacego szeroko stosowanego w Polsce.