[Coronary insufficiency and metabolic hormone ratio in patients with myocardial infarction in the course of a long prospective study].
An angiographic study of coronary bed status and relationships of insulin, cortisol, somatotropin (ST), T3, T4, glucose in 109 Q-wave myocardial infarction (MI) patients aged 47 +/- 0.8 years was performed at rest and during veloergometric stress-test ischemia modelling of exercise tolerance in early (21-26 days) and late (> 5 years) follow-up. The hormones level was found to be significantly related to coronary insufficiency as a result of coronary atherosclerosis both at rest and during muscular stress-test. Coronary failure limiting activity of metabolic processes in the myocardium by chronic hypoxia induces changed proportion of hormones regulating energy metabolism processes. In MI hypometabolic syndrome is developing with specific hormonal "ischemic profile" in which during exercise insulin and thyroxin become leading hormones regulating intracellular exchange of energy; the level of cortisol and ST decreases. Increased need in glucose as a main energy substrate during ischemia and therefore in insulin leads to disturbed carbohydrate metabolism in 33% of patients recorded 3-5 years after MI. The above metabolic changes manifest with increased glucose tolerance and/or clinical signs of diabetes mellitus.
Telkova
I L
IL
Tepliakov
A T
AT
Karpov
R S
RS
D000328:Adult; D003324:Coronary Artery Disease / Q000378:metabolism*; D018450:Disease Progression; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007328:Insulin / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000378:metabolism*; D011446:Prospective Studies; D013974:Thyroxine / Q000378:metabolism*; D013997:Time Factors
D007328:Insulin; D013974:Thyroxine; D006854:Hydrocortisone
Koronarnaia nedostatochnost' i sootnoshenie metabolicheskikh gormonov u bol'nykh infarktom miokarda pri dlitel'nom prospektivnom nabliudenii.