Increases in the mutation frequency at which fusidic acid-resistant Staphylococcus aureus arise with salicylate.
Salicylate was shown to increase the frequency at which a fusidic acid-susceptible strain of Staphylococcus aureus underwent mutation to become fusidic acid-resistant. These fusidic acid-resistant mutants had alterations in spectinomycin and kanamycin resistance levels indicative of mutations in fusA, the gene that encodes elongation factor-G, the target of fusidic acid.
Price
Christopher T D
CTD
*Microbiology Group, School of Biomedical Sciences, Curtin University of Technology, Perth 6845, Western Australia and †Department of Microbiology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA.
Gustafson
John E
JE
*Microbiology Group, School of Biomedical Sciences, Curtin University of Technology, Perth 6845, Western Australia and †Department of Microbiology, Chicago College of Osteopathic Medicine, Midwestern University, Downers Grove, IL 60515, USA.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005672:Fusidic Acid / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009154:Mutation; D012980:Sodium Salicylate / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000235:genetics
D000900:Anti-Bacterial Agents; D005672:Fusidic Acid; D012980:Sodium Salicylate