title: Inhibition by (+)-persenone [corrected] A-related compounds of nitric oxide and superoxide generation from inflammatory leukocytes.
abstract: We have previously reported that persenone A, isolated from avocado fruit, is an effective inhibitor of both nitric oxide (NO) and superoxide (O2-) generation in cell culture systems. In this study, we have prepared four persenone A-related compounds and examined their inhibition of NO and O2- generation from inflammatory leukocytes. Some structural importance in persenone A to attenuate free radical generation is discussed.
authors.affiliation: Division of Applied Life Sciences, Graduate School of Agriculture, Kyoto University, Japan.
authors.forename: O K
authors.initials: OK
authors.lastname: Kim
authors.forename: A
authors.initials: A
authors.lastname: Murakami
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: H W
authors.initials: HW
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Ohigash
mesh_terms: D004952:Esters / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D019770:Lauraceae / Q000737:chemistry*; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism*
chemical_list: D004952:Esters; D005233:Fatty Alcohols; C412488:persenone A; D013481:Superoxides; D009569:Nitric Oxide; C412489:persenone B