Evaluation of cell culture cytotoxicity of five root canal sealers.
The cytotoxicity of four calcium hydroxide-based root canal sealers (Sealapex, CRCS, Apexit, and Sealer 26) and one zinc oxide-eugenol-based sealer (Fill Canal) was evaluated microscopically for morphological changes in rat peritoneal macrophages. The least cytotoxic sealer was Fill Canal, followed in increasing order of cytotoxicity by CRCS, Sealer 26, Apexit, and Sealapex.
Leonardo
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RT
Department of Restorative Dentistry, Faculty of Dentistry of Araraquara, UNESP, Araraquara, Brazil.
Consolaro
A
A
Carlos
I Z
IZ
Leonardo
M R
MR
D000818:Animals; D001729:Bismuth / Q000633:toxicity; D002126:Calcium Hydroxide / Q000633:toxicity; D002462:Cell Membrane / Q000187:drug effects; D002466:Cell Nucleolus / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D002478:Cells, Cultured; D002843:Chromatin / Q000187:drug effects; D003593:Cytoplasm / Q000187:drug effects; D017737:Macrophages, Peritoneal / Q000187:drug effects*; D051381:Rats; D012387:Root Canal Filling Materials / Q000633:toxicity*; D012459:Salicylates / Q000633:toxicity; D018709:Statistics, Nonparametric; D014617:Vacuoles / Q000187:drug effects; D015034:Zinc Oxide / Q000633:toxicity; D015035:Zinc Oxide-Eugenol Cement / Q000633:toxicity
C074418:Apexit; D002843:Chromatin; D012387:Root Canal Filling Materials; D012459:Salicylates; C080620:Sealer 26; D015035:Zinc Oxide-Eugenol Cement; C055601:Sealapex; C075563:Calcibiotic Root Canal Sealer; D002126:Calcium Hydroxide; D015034:Zinc Oxide; D001729:Bismuth