title: Quantitative CMV antigenemia correlated with ophthalmoscopic screening for CMV retinitis in AIDS patients.
abstract: To assess the efficacy of the cytomegalovirus (CMV) antigen test in detecting the clinical presence of CMV retinitis. A retrospective chart review was conducted on 86 HIV positive patients who underwent dilated fundus exams for CMV retinitis. All patients had a CMV antigen assay performed within three months of their retinal exam. At a level of 45, the antigen test has a sensitivity of 96% in correctly detecting CMV retinitis and a specificity of 90.2%. The negative and positive predictive values of the antigen test were 98.2% and 80%, respectively. CMV antigen blood test provides a useful screening tool in detecting the presence or absence of CMV retinitis. An antigen level less than 45 strongly suggests the absence of retinitis.
authors.affiliation: Department of Ophthalmology, Yale University, Center for Sight, Venice, Florida 34792, USA.
authors.forename: J
authors.initials: J
authors.lastname: Fezza
authors.forename: M
authors.initials: M
authors.lastname: Weitzman
authors.forename: D
authors.initials: D
authors.lastname: Shoemaker
authors.forename: C
authors.initials: C
authors.lastname: Gremillion
authors.forename: H
authors.initials: H
authors.lastname: Chen
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000175:diagnosis*; D000293:Adolescent; D000328:Adult; D000956:Antigens, Viral / Q000097:blood*; D003587:Cytomegalovirus / Q000276:immunology*; D017726:Cytomegalovirus Retinitis / Q000097:blood / Q000175:diagnosis*; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000821:virology; D009887:Ophthalmoscopy; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D000956:Antigens, Viral