title: [Conservative therapy for early-stage breast cancer].
abstract: An evaluation of the data on the treatment of 298 cases of breast cancer (stages IIa and IIb) showed that a reduced frequency of loco-regional recurrences, after post-operative irradiation as a component of conservative therapy, was followed by improvement in quality of life. This was particularly apparent in patients with pT2pN1 tumors. It was also found that after extended dissection of axillary lymph nodes at all three levels, a dose of 50 Gy was sufficient without additional irradiation of the cicatrix. Nor was it necessary to expose the axillary area in cases of three or less lymph node recurrences provided that at least 6 resected nodes were studied histologically. Following conservative therapy, 5-year survival was 97%, while relapse-free survival--82%.
authors.affiliation: N.N. Blokhin Center for Oncology Research, Russian Academy of Medical Sciences, Moscow.
authors.forename: G V
authors.initials: GV
authors.lastname: Goldobenko
authors.forename: Z P
authors.initials: ZP
authors.lastname: Mikhina
authors.forename: M
authors.initials: M
authors.lastname: Iakh'ia
authors.forename: V M
authors.initials: VM
authors.lastname: Ivanov
authors.forename: I Iu
authors.initials: IIu
authors.lastname: Dolgov
mesh_terms: D000328:Adult; D001365:Axilla / Q000601:surgery; D001943:Breast Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015994:Incidence; D008197:Lymph Node Excision; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
vernacular_title: K probleme organosokhraniaiushchego lecheniia bol'nykh rakom molochnoĭ zhelezy rannikh stadiĭ.