Solid-phase synthesis of oligonucleotides containing a bipyridine ligand at the 3'-3' inversion of polarity site.
The preparation of a solid support useful for the synthesis of oligonucleotides with a 3'-3' inversion of polarity, via a linker containing a chelating molecule, namely 2,2'-bipyridine, is described.
Galeone
A
A
Dip. di Chimica delle Sostanze Naturali, Univ. di Napoli Federico II, Italy.
Mayol
L
L
Oliviero
G
G
Rigano
D
D
Varra
M
M
D015082:2,2'-Dipyridyl / Q000737:chemistry*; D020137:Base Pair Mismatch; D008024:Ligands; D009841:Oligonucleotides / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D008024:Ligands; D009841:Oligonucleotides; D015082:2,2'-Dipyridyl