title: Effect of vibration on auditory organ systems in low-birth weight infants treated with high-frequency oscillatory ventilation: 5 year outcome.
abstract: BACKGROUND
  To determine the effects of vibration exposure caused by high-frequency oscillatory ventilation (HFOV) on the auditory organ systems in low-birth weight (LBW) infants.
  
  
  METHODS
  Between 1989 and 1990, 30 LBW infants who received assisted ventilation with HFOV (n = 14) or conventional mechanical ventilation (CMV; n = 16) in the level III neonatal intensive care unit at Tokyo Metropolitan Ohtsuka Hospital were enrolled in this study. The effects of vibration exposure on the auditory system structures were investigated with auditory brainstem responses (ABR) at 37-41 weeks of postconceptional age and at 6, 12, 18 and 24 months of age until they passed and follow-up studies were performed at least until 5 years of age.
  
  
  RESULTS
  All infants enrolled in the study survived at discharge and one (7.1%) infant in the HFOV group and two (12.5%) in the CMV group failed the initial ABR test, but there were no significant differences between the two groups. Auditory brainstem response abnormalities were still observed in one infant in the HFOV group at 6 months of age, but this child died at 9 months of age because of meningitis. In contrast, in the CMV group, one patient passed the ABR test at 6 months of age, but another remained abnormal at 5 years of age. One of three infants with ABR abnormalities at 6 months of age had neurologic sequelae at 5 years of age and one of 28 infants who passed the initial ABR test was detected with cerebral palsy. No patients with hearing loss were clinically detected at 5 years of age.
  
  
  CONCLUSIONS
  The results of the serial ABR examinations and the 5 year follow-up studies suggest that vibration exposure caused by HFOV may not increase the adverse effects on the auditory system in LBW infants.
authors.affiliation: Department of Pediatrics, Tokyo Metropolitan Ohtsuka Hospital, Japan. hosonos@rb3.so-net.ne.jp
authors.forename: S
authors.initials: S
authors.lastname: Hosono
authors.forename: S
authors.initials: S
authors.lastname: Imura
authors.forename: K
authors.initials: K
authors.lastname: Akiyama
authors.forename: I
authors.initials: I
authors.lastname: Takigawa
authors.forename: S
authors.initials: S
authors.lastname: Ishizeki
authors.forename: H
authors.initials: H
authors.lastname: Takeda
mesh_terms: D001300:Audiometry, Evoked Response; D001304:Auditory Diseases, Central / Q000209:etiology; D001306:Auditory Pathways / Q000473:pathology*; D002675:Child, Preschool; D016057:Evoked Potentials, Auditory, Brain Stem; D005500:Follow-Up Studies; D006612:High-Frequency Ventilation / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D014732:Vibration / Q000009:adverse effects*