title: Peripheral neuropathy without cryoglobulinemia in patients with hepatitis C virus infection.
abstract: BACKGROUND
  An association between essential mixed cryoglobulinemia and hepatitis C virus infection has been documented by many reports. Some clinical manifestations such as purpura, arthralgia, vascular lesions and peripheral neuropathies are also connected with the presence of detectable cryoglobulins. The association between HCV infection, the presence of mixed cryoglobulinemia and peripheral neuropathy is well documented. The aim of this study was to define the possible presence of peripheral neuropathy in HCV patients without detectable cryoglobulins and the possible association with the different genotypes.
  
  
  METHODS
  Twenty patients (11 females, 9 males) with chronic HCV hepatitis and without detectable cryoglobulins were submitted to neurological and electrophysiological studies to detect a possible peripheral neurological involvement. In all patients the HCV infection was assumed by the presence of antibodies to HCV with ELISA assay and then confirmed with recombinant immunoblot assay. HCV genotyping was obtained by INNO LIPA in 15 out of 20 patients. In 4 patients a sural nerve biopsy was possible.
  
  
  RESULTS
  Genotype 1b was present in 80% of patients, while 1a in 13.3% and 4 in 6.6%. Thirteen patients had positive neurological anamnesis (65%), while neurological examination was positive in 40% of the cases. Electromyographic study was positive in 50% of subjects. The sural nerve biopsies agreed with axonal degeneration in amyelinated fibres.
  
  
  CONCLUSIONS
  Our results suggest a possible peripheral neurological system involvement in patients with HCV infection without cryoglobulins.
authors.affiliation: Department of Medical Therapy, University La Sapienza, Rome, Italy. paolettiv@uniroma1.it
authors.forename: V
authors.initials: V
authors.lastname: Paoletti
authors.forename: L
authors.initials: L
authors.lastname: Donnarumma
authors.forename: A
authors.initials: A
authors.lastname: De Matteis
authors.forename: A
authors.initials: A
authors.lastname: Mammarella
authors.forename: G
authors.initials: G
authors.lastname: Labbadia
authors.forename: A
authors.initials: A
authors.lastname: Musca
authors.forename: A
authors.initials: A
authors.lastname: Francia
mesh_terms: D000328:Adult; D000368:Aged; D003449:Cryoglobulinemia / Q000150:complications*; D004576:Electromyography; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D019698:Hepatitis C, Chronic / Q000150:complications* / Q000503:physiopathology / Q000821:virology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000473:pathology; D010523:Peripheral Nervous System Diseases / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D013497:Sural Nerve / Q000473:pathology