[Oxadin effect on actinomycetes strains].
The results of research show that oxadin has mutagenous effect on the tested actinomyces strains, in particular on Streptomyces albus--producer of the polyether antibiotic salinomycin. The colonies grown up after spores treatment with oxadin, have been tested for auxotrophy, morphological mutations and biosynthesis of the antibiotic salinomycin. Treatment of Streptomyces albus strain with 10% oxadin for 10 or 20 min provided the isolation of highly active strains. Dispersion analysis data revealed statistically significant differences between the control (non treated) and the oxadin-treated Streptomyces albus populations.
Naidenova
M M
MM
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Michaĭilov
Y G
YG
Ivanova
I
I
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D015169:Colony Count, Microbial; D007928:Lethal Dose 50; D009153:Mutagens / Q000494:pharmacology*; D010078:Oxazines / Q000494:pharmacology*; D013172:Spores, Fungal / Q000187:drug effects; D013302:Streptomyces / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism
D000900:Anti-Bacterial Agents; D009153:Mutagens; D010078:Oxazines; C085142:oxadin
Issledovanie deĭstviia oksadina na aktinomitsetnye shtammy.