title: [Acute effects of oxygen on dyspnea and exercise tolerance in patients with pulmonary emphysema with only mild exercise-induced oxyhemoglobin desaturation].
abstract: The effects of oxygen on dyspnea and exercise tolerance during a 6-mimute walk test were examined in 10 patients with chronic pulmonary emphysema (CPE) who had only mild hypoxemia at rest (PaO2 > 60 Torr) and mild exercise-induced oxyhemoglobin desaturation (lowest SpO2 > 88%) on compressed air. As a whole, oxygen supplementation (2 l/min) resulted in a 7% increase in the distance walked in 6 min (6 MD), a 3% increase in the lowest SpO2, and an 8% decrease in the dyspnea score. In 6 of 7 patients with severe airflow limitation (one-second forced expiratory volume (FEV1) < 40% of predicted value), 6 MD (7-15%) increased significantly on oxygen, an improvement that correlated significantly with FEV1 (r = -0.65, p < 0.05). These results suggest that supplementary oxygen improves dyspnea and exercise tolerance in CPE patients with only mild exercise-induced hypoxemia despite severe airflow limitation. The long-term efficacy of oxygen in such patients needs further study.
authors.affiliation: First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Japan. Kakeyu Misayama Hospital, Maruko-Machi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuzawa
authors.forename: K
authors.initials: K
authors.lastname: Kubo
authors.forename: K
authors.initials: K
authors.lastname: Fujimoto
authors.forename: S
authors.initials: S
authors.lastname: Eda
authors.forename: S
authors.initials: S
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Koizumi
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000388:Air; D002908:Chronic Disease; D004311:Double-Blind Method; D004417:Dyspnea / Q000209:etiology / Q000628:therapy*; D015444:Exercise / Q000502:physiology*; D017079:Exercise Tolerance / Q000502:physiology*; D005541:Forced Expiratory Volume; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010102:Oxygen Inhalation Therapy; D010108:Oxyhemoglobins / Q000378:metabolism*; D011656:Pulmonary Emphysema / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D012720:Severity of Illness Index
chemical_list: D010108:Oxyhemoglobins