Is multiple sclerosis severity a genetically influenced trait?
Multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system of unknown pathogenesis, is a complex disease with a multifactorial etiology determined by both genetic and environmental factors. The pathological entity MS has a wide phenotype, and also the severity of the disease is widely variable. Clinical heterogeneity of the disease might arise from different genotype-phenotype interactions. Results of recent studies and theories about the modifying role of different genes in the course and the severity of MS are here discussed.
Cocco
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Department of Neuroscience, University of Cagliari, Multiple Sclerosis Center, Ospedale Binaghi, Italy.
Marrosu
M G
MG
D001057:Apolipoproteins E / Q000235:genetics; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D018450:Disease Progression; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D007378:Interleukins / Q000235:genetics; D005810:Multigene Family / Q000235:genetics; D009103:Multiple Sclerosis / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D011960:Receptors, Estrogen / Q000235:genetics
D001057:Apolipoproteins E; D007378:Interleukins; D011960:Receptors, Estrogen