[Synthetic peptide designs based on immunoactive fragments of the VP1 protein of the foot-and-mouth disease virus strain A22].
Peptide constructs consisting of 44-53 aa were synthesized on the basis of sequences 135-159, 170-190 and 197-213 of VP1 from the foot-and-mouth disease A22 strain. Immunogenic and protective properties of the peptide constructs were studied in guinea pigs and mice of three lines. The constructs were shown to induce higher levels of antibodies and exhibit higher protective effects than the separate peptides. The most active among the peptides studied was the construct involving the VP1 fragments 135-160 and 170-190: it protected pigs from the experimental infection by the foot-and-mouth disease virus.
Kupriianova
M A
MA
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP-7 Moscow, 117871 Russia. fmdv@ibch.ru
Zhmak
M N
MN
Koroev
D O
DO
Chepurkin
A V
AV
Vol'pina
O M
OM
Ivanov
V T
VT
D000595:Amino Acid Sequence; D000818:Animals; D005537:Aphthovirus / Q000737:chemistry*; D002213:Capsid / Q000737:chemistry*; D036022:Capsid Proteins; D006168:Guinea Pigs; D051379:Mice; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry*
D036022:Capsid Proteins; D010446:Peptide Fragments
Sinteticheskie peptidnye konstruktsii na osnove immunoaktivnykh fragmentov belka VP1 virusa iashchura shtamma A22.