title: Early pregnancy failure--current management concepts.
abstract: Approximately one in four women will experience a miscarriage during her lifetime. For more than 50 years, the standard management of early pregnancy failure has been a dilatation and curettage (D & C). Typically, the procedure is performed in an operating room, which significantly increases cost. There is little objective information in the modem literature to prove that a D & C for all patients will lower morbidity or improve emotional well being. Treatment options include expectant management, D & C in an outpatient setting, and medical management with misoprostol (not approved by the U.S. Food and Drug Administration for treatment of early pregnancy failure). The medical literature supports that expectant management may result in more complications, including the need for "emergent" curettage, if clinicians do not understand the true normal course of expectant management. In general, women prefer some form of active management. Dilatation and curettage can be performed safely in the office or other outpatient setting using manual vacuum aspiration. Vaginal misoprostol will cause expulsion in 80% to 90% of women up to 13 weeks' uterine size or gestation, including patients who have a gestational sac present. However, these data come from only three trials involving a total of 42 subjects treated with vaginal misoprostol, and another study of 42 women who received vaginal misoprostol for "missed abortion" before a scheduled D & C. There is a significant lack of information from large-scale studies about when treatment is necessary and the relative efficacy, rates of side effects, and acceptability of these various treatment options for early pregnancy failure.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Magee-Women's Hospital, Pennsylvania 15213-3180, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Creinin
authors.forename: J L
authors.initials: JL
authors.lastname: Schwartz
authors.forename: R S
authors.initials: RS
authors.lastname: Guido
authors.forename: H C
authors.initials: HC
authors.lastname: Pymar
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000030:Abortion, Missed / Q000628:therapy*; D004107:Dilatation and Curettage / Q000191:economics* / Q000379:methods; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000627:therapeutic use*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D016896:Treatment Outcome; D014619:Vacuum Curettage / Q000379:methods*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol