title: Decreased level of EEG-vigilance in acute mania as a possible predictor for a rapid effect of methylphenidate: a case study.
abstract: About one third of manic patients show a decreased Electroencephalographic Vigilance Level (EVL). In two patients with recurrent manias the hypothesis was tested that the EEG may be used to predict the therapeutic response to methylphenidate. Patient A (with a decreased EVL) responded rapidly to methylphenidate with a considerable reduction of symptoms and a clear increase of EVL, whereas patient B (normal EVL) did not show any change, neither clinically nor in the EEG.
authors.affiliation: Berlin Lithium Clinic, Berlin, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Bschor
authors.forename: B
authors.initials: B
authors.lastname: Müller-Oerlinghausen
authors.forename: G
authors.initials: G
authors.lastname: Ulrich
mesh_terms: D001714:Bipolar Disorder / Q000188:drug therapy* / Q000503:physiopathology*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use*; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use*; D008875:Middle Aged
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate