Multidrug-resistance protein 1 in focal cortical dysplasia.
Drug resistance in epilepsy is poorly understood. We used routine immunohistochemistry to assess overexpression of a multidrug-resistance protein in dysplastic neurons, glia, and around vessels in surgically resected epileptogenic human brain tissue. We showed non-tumoral overexpression of this multidrug-resistance protein, which might contribute to drug resistance in epilepsy caused by focal cortical dysplasia.
Sisodiya
S M
SM
Lin
W R
WR
Squier
M V
MV
Thom
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis*; D002540:Cerebral Cortex / Q000737:chemistry* / Q000473:pathology; D004827:Epilepsy / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1