title: Effect of xerostomic medications on stimulated salivary flow rate in patients with Sjögren's syndrome.
abstract: OBJECTIVE
  The purpose of this study was to examine the effect of xerostomic medications on the salivary output of patients with Sjögren's syndrome.
  
  
  METHODS
  Of 62 patients evaluated in this study, 23 were not using medication, and 39 were using between 1 and 6 medications with xerostomic side effect.
  
  
  RESULTS
  The mean +/- SEM stimulated parotid output was 0.33 +/- 0.07 mL/min per gland for patients who were not using medication and 0.33 +/- 0.04 mL/min per gland for patients using (1 to 6) medications. Analyses did not reveal a significant difference in salivary output between these groups. The salivary output of patients using various numbers of medications (1 or 2; 3 or 4; 5 or 6) was also compared. Analysis revealed no significant difference in salivary output related to the number of xerostomic medications used.
  
  
  CONCLUSIONS
  The use of xerostomic medications may not necessarily affect stimulated parotid flow rate in patients with Sjögren's syndrome. These results suggested that gustatory stimulation may be adequate to overcome the inhibitory effect induced by xerostomic medications.
authors.affiliation: Department of Periodontics, Baylor College of Dentistry, Texas A&M University System, Dallas, Texas, USA.
authors.forename: D D
authors.initials: DD
authors.lastname: Simmons
authors.forename: I
authors.initials: I
authors.lastname: Al-Hashimi
authors.forename: N
authors.initials: N
authors.lastname: Haghighat
mesh_terms: D000704:Analysis of Variance; D000928:Antidepressive Agents / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D005260:Female; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism; D012472:Salivation / Q000187:drug effects*; D012636:Secretory Rate / Q000187:drug effects; D012859:Sjogren's Syndrome / Q000503:physiopathology*; D018709:Statistics, Nonparametric; D014987:Xerostomia / Q000139:chemically induced* / Q000503:physiopathology
chemical_list: D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D006634:Histamine H1 Antagonists