[Induction of oral tolerance: a new therapeutic strategy for autoimmune diseases?].
The phenomenon of oral tolerance (the state of systemic hyporesponsiveness after oral antigen delivery) has been known for a long time, nevertheless it turned out only in the last decades that it could be used for the treatment of autoimmune diseases. The induction of oral tolerance was shown to be very effective for the prevention of disease development in numerous animal models of human autoimmune diseases, and to a lesser extent for the alleviation of symptoms in already ill animals. As opposed to these promising experiments, no such considerable results were found in human trials. In this review. I will try to summarize the present status of these experiments and to discuss the possible advantages and disadvantages of this therapeutic protocol.
Igaz
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Medizinische Klinik II für Innere Medizin, Semmelweis Universität, Medizinische Fakultät, Szentkiralyi ut. 46, H-1088 Budapest, Ungarn. igapet@bel2.sote.hu
D000284:Administration, Oral; D000818:Animals; D001324:Autoantigens / Q000008:administration & dosage* / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D003888:Desensitization, Immunologic / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans
D001324:Autoantigens
Die Induktion oraler Toleranz: eine neue Therapiestrategie für Autoimmunerkrankungen?