title: Successful pregnancy in a patient with familial sea-blue histiocyte syndrome.
abstract: A 27-year-old Indian woman at 23 weeks' gestation presented with decompensated liver cirrhosis, coagulopathy, restrictive lung disease with cor pulmonale and preeclampsia. She was diagnosed to have sea-blue histiocyte syndrome (SBHS) at the age of 13 years and was treated conservatively. There was worsening liver, respiratory and bone marrow function as the pregnancy progressed. She underwent a successful pregnancy despite her poor medical condition and advanced disease state. We described the first case of familial SBHS in a pregnant patient from Asia.
authors.affiliation: Department of Haematology and Transplantation, MAKNA-HUKM Cancer Institute, Hospital Universiti Kebangsaan Malaysia (HUKM), Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur.
authors.forename: S A
authors.initials: SA
authors.lastname: Fadilah
authors.forename: N R
authors.initials: NR
authors.lastname: Mazeni
authors.forename: S K
authors.initials: SK
authors.lastname: Cheong
mesh_terms: D000328:Adult; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012618:Sea-Blue Histiocyte Syndrome / Q000235:genetics* / Q000473:pathology; D013154:Spleen / Q000473:pathology