title: New efficient synthesis of thymidine cyclic 3',5'-phosphorofluoridate and its sulfur analogue via the phosphoroamidite route.
abstract: We describe the convenient synthesis of thymidine cyclic 3', 5'-phosphorofluoridate 6, which is superior to that previously reported. Our procedure is based on a sequence of reactions utilizing 3 as the key substrate. Similar sequence of reaction leads to the sulfur analogues of 6 the thymidine cyclic 3',5'-phosphorofluoridothioate 7.
authors.affiliation: Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lódź.
authors.forename: W
authors.initials: W
authors.lastname: Dabkowski
authors.forename: I
authors.initials: I
authors.lastname: Tworowska
authors.forename: J
authors.initials: J
authors.lastname: Michalski
authors.forename: F
authors.initials: F
authors.lastname: Cramer
mesh_terms: D009682:Magnetic Resonance Spectroscopy; D009943:Organophosphorus Compounds / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013455:Sulfur / Q000737:chemistry*; D013873:Thionucleotides / Q000737:chemistry*; D013936:Thymidine / Q000031:analogs & derivatives / Q000737:chemistry*
chemical_list: D009943:Organophosphorus Compounds; D013873:Thionucleotides; C423485:thymidine cyclic 3',5'-phosphorofluoridate; D013455:Sulfur; D013936:Thymidine