Design and synthesis of new potent human cytomegalovirus (HCMV) inhibitors based on internally hydrogen-bonded 1,6-naphthyridines.
1,6-Naphthyridine-2-carboxylic acid benzylamides are potent anti-HCMV compounds. Replacement of the amide moiety by other groups containing internal hydrogen bonds was undertaken to extend the SAR. Our results indicated that the urca derivatives showed very good activity.
Chan
L
L
BioChem Pharma Inc., Laval, Québec, Canada.
Stefanac
T
T
Lavallée
J F
JF
Jin
H
H
Bédard
J
J
May
S
S
Falardeau
G
G
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003587:Cytomegalovirus / Q000187:drug effects*; D015195:Drug Design; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D009281:Naphthalenes / Q000737:chemistry; D009287:Naphthyridines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013854:Thioamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D009281:Naphthalenes; D009287:Naphthyridines; D013854:Thioamides; C031721:naphthalene