A useful marker for evaluating tissue-engineered products: gap-junctional communication for assessment of the tumor-promoting action and disruption of cell differentiation in tissue-engineered products.
An in vitro system for evaluating the safety of tissue-engineered products is a convenient because of its rapidity and low cost. On the basis of recent studies, intercellular channels called gap-junctions are considered to play an important role on the tumor-promotion stage during the tumorigenesis induced by polyurethanes. Further, we also demonstrate the significance of the intercellular communication during neuronal cell differentiation. From these results, we propose a survey of the function of the gap-junctional communication as a probable useful marker for evaluating the safety of tissue-engineered products.
Tsuchiya
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National Institute of Health Sciences, Division of Medical Devices, Tokyo, Japan. tsuchiya@nihs.go.jp
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001698:Biomedical Engineering; D002273:Carcinogens; D002454:Cell Differentiation; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D017630:Connexins / Q000378:metabolism; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D004622:Embryo, Mammalian / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects; D017629:Gap Junctions / Q000187:drug effects; D019344:Lactic Acid / Q000494:pharmacology; D009474:Neurons / Q000166:cytology*; D010641:Phenotype; D011140:Polyurethanes / Q000378:metabolism; D011205:Povidone / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012828:Silicones / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D013866:Thioguanine / Q000494:pharmacology; D014638:Vanadates / Q000494:pharmacology
D000970:Antineoplastic Agents; D002273:Carcinogens; D017630:Connexins; D011140:Polyurethanes; D012828:Silicones; D019344:Lactic Acid; D014638:Vanadates; D013866:Thioguanine; D011205:Povidone; D013755:Tetradecanoylphorbol Acetate