title: [Characteristics of effects of acetylene amino alcohols M-cholinoreceptor blockers on the dopaminergic system in Daphnia magna].
abstract: Haloperidol and dimethpromide exhibit the properties of dopamine antagonists in the experiments on Daphnia magna Straus (Crustaceae family). Haloperidol, in contrast to dimethpromide, does not significantly influence the toxic effect of apomorphine. It is suggested that acetylene aminoalcohol derivatives are selective ligands for one of the subtypes of dopamine receptors.
authors.affiliation: Institute of Toxicology, Ministry of Public Health of the Russian Federation, ul. Bekhtereva 1, St. Petersburg, 193019 Russia.
authors.forename: A B
authors.initials: AB
authors.lastname: Kosmachev
authors.forename: V D
authors.initials: VD
authors.lastname: Tonkopiĭ
authors.forename: N P
authors.initials: NP
authors.lastname: Podosinovikova
authors.forename: A O
authors.initials: AO
authors.lastname: Zagrebin
authors.forename: E A
authors.initials: EA
authors.lastname: Evdokimova
authors.forename: N M
authors.initials: NM
authors.lastname: Libman
authors.forename: V V
authors.initials: VV
authors.lastname: Petrov
authors.forename: V B
authors.initials: VB
authors.lastname: Dolgo-Saburov
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000605:Amino Alcohols / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000633:toxicity; D001115:Arecoline / Q000633:toxicity; D003621:Daphnia; D004298:Dopamine / Q000378:metabolism* / Q000633:toxicity; D018492:Dopamine Antagonists / Q000633:toxicity; D004336:Drug Antagonism; D006220:Haloperidol / Q000633:toxicity; D007928:Lethal Dose 50; D008024:Ligands; D018727:Muscarinic Antagonists / Q000494:pharmacology*
chemical_list: D000605:Amino Alcohols; D018492:Dopamine Antagonists; D008024:Ligands; D018727:Muscarinic Antagonists; D001115:Arecoline; D006220:Haloperidol; D001058:Apomorphine; D000114:Acetylene; D004298:Dopamine
vernacular_title: Osobennosti mekhanizma deĭstviia m-kholinoblokatorov iz gruppy atsetilenovykh aminospirtov na dofaminergicheskuiu sistemu Daphnia magna.