title: New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris.
abstract: Five new constituents including a flavonoid, artemisidin A (1), and four coumarins, artemicapins A (2), B (3), C (4) and D (5), together with 70 known compounds (6-75), have been isolated and characterized from the aerial part of Artemisia capillaris. The structures of these compounds were determined from spectral analyses and/or chemical evidence. Among them, 15 compounds (3, 6, 10, 18. 30-32, 38-41, 44, 45, 51, and 55) showed antiplatelet aggregation activity and three compounds (10, 17, and 51) demonstrated significant activity against HIV replication in H9 lymphocytic cells.
authors.affiliation: Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China. tswu@mail.ncku.edu.tw
authors.forename: T S
authors.initials: TS
authors.lastname: Wu
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Tsang
authors.forename: P L
authors.initials: PL
authors.lastname: Wu
authors.forename: F W
authors.initials: FW
authors.lastname: Lin
authors.forename: C Y
authors.initials: CY
authors.lastname: Li
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000114:Acetylene / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D019380:Anti-HIV Agents / Q000302:isolation & purification*; D019306:Artemisia / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects; D002109:Caffeic Acids / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013053:Spectrophotometry
chemical_list: D019380:Anti-HIV Agents; D002109:Caffeic Acids; D003374:Coumarins; D010975:Platelet Aggregation Inhibitors; C044736:phenylacetylene; D000114:Acetylene; C040048:caffeic acid