[Dopaminergic agonists in the treatment of Parkinson's disease].
After levodopa, dopaminergic agonists are the most powerful agents in idiopathic Parkinson's disease treatment. Used in monotherapy or rather in early combination with levodopa, they allow a dramatic reduction of long-term motor side effects of the latter: onset and peak-dose dyskinesias, early morning dystonias. Their gastro-intestinal (nauseas) and moreover psychiatric (confusion and hallucinations) side effects limit their use, notably in geriatric populations. Superiority of so-called "second generation" agonists (ropinirole, pramipexole) on "first generation" agonists (bromocriptine, pergolide) remains to be proved.
Supiot
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F
Service de Neurologie, Hôpital Erasme.
Sternon
J
J
Zegers de Beyl
D
D
D000368:Aged; D000978:Antiparkinson Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001058:Apomorphine / Q000627:therapeutic use; D052160:Benzothiazoles; D001682:Biological Availability; D001971:Bromocriptine / Q000627:therapeutic use; D002396:Catechols / Q000627:therapeutic use; D018491:Dopamine Agonists / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D004338:Drug Combinations; D004342:Drug Hypersensitivity; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced; D007211:Indoles / Q000493:pharmacokinetics / Q000627:therapeutic use; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D008657:Metabolic Clearance Rate; D009570:Nitriles; D010300:Parkinson Disease / Q000188:drug therapy*; D010479:Pergolide / Q000627:therapeutic use; D000077487:Pramipexole; D012642:Selegiline / Q000627:therapeutic use; D013844:Thiazoles / Q000493:pharmacokinetics / Q000627:therapeutic use
D000978:Antiparkinson Agents; D052160:Benzothiazoles; D002396:Catechols; D018491:Dopamine Agonists; D004338:Drug Combinations; D007211:Indoles; D009570:Nitriles; D013844:Thiazoles; C046649:ropinirole; D010479:Pergolide; D012642:Selegiline; D001971:Bromocriptine; D007980:Levodopa; C071192:entacapone; D000077487:Pramipexole; D001058:Apomorphine
Les agonistes dopaminergiques dans le traitement de la maladie de Parkinson.