title: Diabetic ketoacidosis in a patient with acromegaly.
abstract: Abnormalities of glucose metabolism are a common feature of acromegaly. Overt diabetes mellitus develops in about 10-15% of patients. We present an unusual complication of acromegaly: a 37-year old man with a 2-year history of acromegaly developed diabetic ketoacidosis 3 weeks after transsphenoidal adenomectomy. No specific cause for this sudden metabolic derangement could be demonstrated. Insulin need was very high in the first days after the onset of ketoacidosis, but was considerably reduced after initiation of treatment with octreotide and after successful re-operation.
authors.affiliation: Department of Metabolic Diseases and Gastroenterology, Medical University of Łódź, ul. Kopcinskiego 22, 90-153 Łódź, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Kopff
authors.forename: S
authors.initials: S
authors.lastname: Mucha
authors.forename: B H
authors.initials: BH
authors.lastname: Wolffenbuttel
authors.forename: J
authors.initials: J
authors.lastname: Drzewoski
mesh_terms: D000172:Acromegaly / Q000150:complications*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D016883:Diabetic Ketoacidosis / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D005951:Glucose Tolerance Test; D019382:Human Growth Hormone / Q000097:blood; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008297:Male; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000601:surgery; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019382:Human Growth Hormone; D007334:Insulin-Like Growth Factor I