Relapse as histoid leprosy after receiving multidrug therapy (MDT); a report of three cases.
The histoid type of leprosy has been described as occurring in lepromatous leprosy patients who relapse after many years of apparently successful dapsone monotherapy. Three patients who had received the World Health Organization-recommended regimens of multidrug therapy (WHO/MDT) relapsed as histoid leprosy 12-15 years after completion of treatment. In one patient, through mouse foot pad studies, the bacilli were found to be sensitive to rifampin and clofazimine and resistant to dapsone. In the other two patients mouse foot pad studies were inconclusive. The patients were re-started on WHO/MDT. Two patients took regular treatment and improved, both clinically and bacteriologically. One patient was irregular in treatment, and 1 year after re-starting WHO/MDT nodules were still present although the bacterial index had fallen slightly.
Shaw
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IN
Department of Community Health, Schieffelin Leprosy Research and Training Center, Karigiri, Vellore District, Tamil Nadu, South India 632 106.
Ebenezer
G
G
Rao
G S
GS
Natrajan
M M
MM
Balasundaram
B
B
D000072:Acedapsone / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D002991:Clofazimine / Q000008:administration & dosage / Q000627:therapeutic use*; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007194:India; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015440:Leprosy, Lepromatous / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009166:Mycobacterium leprae / Q000187:drug effects; D012008:Recurrence; D012293:Rifampin / Q000008:administration & dosage / Q000627:therapeutic use*
D007917:Leprostatic Agents; D000072:Acedapsone; D003622:Dapsone; D002991:Clofazimine; D012293:Rifampin