title: [Monocytic B-cells represent a new cell population that is mainly recruited from unmutated polyconal naive B-cells].
abstract: Monocytoid B-cells appear as a distinct B-cell population in a number of lymphadenopathies but above all in Piringer's lymphadenopathy. Up until now, their assignment to a recognised B-cell subpopulation has not been conclusively achieved. Immunohistological studies have shown characteristics in common with the tumour cells of hairy cell leukemia and also with so-called splenic marginal zone cells. In order to unequivocally clarify their B-cell differentiation stage we have isolated single monocytoid B-cells from immunostained frozen sections and have analysed their immunoglobulin chain gene rearrangements. In addition we have studied the Ig-expression of monocytoid B-cells at both the RNA and protein levels.
authors.affiliation: Institut für Pathologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin.
authors.forename: K
authors.initials: K
authors.lastname: Stein
authors.forename: M
authors.initials: M
authors.lastname: Hummel
authors.forename: P
authors.initials: P
authors.lastname: Korbjuhn
authors.forename: H D
authors.initials: HD
authors.lastname: Foss
authors.forename: I
authors.initials: I
authors.lastname: Anagnostopoulos
authors.forename: T
authors.initials: T
authors.lastname: Marafioti
authors.forename: H
authors.initials: H
authors.lastname: Stein
mesh_terms: D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology*; D002454:Cell Differentiation; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D007128:Immunoglobulin Fragments / Q000235:genetics; D007943:Leukemia, Hairy Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology; D008206:Lymphatic Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D009000:Monocytes / Q000276:immunology / Q000473:pathology
chemical_list: D007128:Immunoglobulin Fragments
vernacular_title: Monozytoide B-Zellen stellen eine neue B-Zellpopulation dar, die sich zumeist aus polyklonalen unmutierten naiven B-Zellen rekrutiert.