Synthesis and cytotoxic activity of 2-dialkylaminoethylamino substituted xanthenone and thioxanthenone derivatives.
The synthesis and biological evaluation of some new pyranoxanthenones and pyranothioxanthenones, substituted with flexible amino side-chains, and their evaluation as potential antitumor agents is described. The cytotoxic activity of the compounds and their eventual selective effect on a phase of the cell cycle were evaluated in vitro, using the murine lymphocytic L1210 leukemia cell line. The new aminoderivatives exhibited highly potent cytotoxicity against the leukemia L1210 cell line when compared to acronycine. All the compounds induced a partial accumulation of cells in the G2 + M phase of the cell cycle.
Kostakis
I
I
University of Athens, Department of Pharmacy, Greece.
Ghirtis
K
K
Pouli
N
N
Marakos
P
P
Skaltsounis
A L
AL
Leonce
S
S
Caignard
D H
DH
Atassi
G
G
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005650:Fumarates / Q000138:chemical synthesis; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D014407:Tumor Cells, Cultured; D014966:Xanthenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D005650:Fumarates; D014966:Xanthenes