Kainate receptor pharmacology and physiology.
Glutamate is the primary neurotransmitter in the central nervous system. One of the classes of ionotropic glutamate receptors is kainate receptors. Recent developments in the pharmacology of kainate receptors have resulted in the emergence of several selective agonists and antagonists. These compounds have allowed scientists to begin to probe the functional properties of these receptors in neurons and gain a better understanding of the role of these receptors in the nervous system.
Bleakman
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Eli Lilly and Company, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana 46285-0510, USA. bleakman_david@lilly.com
D000494:Allosteric Regulation; D000679:Amygdala / Q000166:cytology / Q000378:metabolism; D000818:Animals; D002531:Cerebellum / Q000166:cytology / Q000378:metabolism; D003001:Cloning, Molecular; D015536:Down-Regulation; D004553:Electric Conductivity; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D006801:Humans; D009474:Neurons / Q000378:metabolism; D018092:Kainic Acid Receptors / Q000819:agonists / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism; D012668:Trigeminal Ganglion / Q000166:cytology / Q000378:metabolism
D018092:Kainic Acid Receptors