[Pathogenicity of Burkholderia pseudomallei: extracellular and surface antigen functions].
The data of literature and the results of investigations carried out by the authors on the analysis of B. pseudomallei pathogenicity factors. They include mucoid, endotoxin, lecithinase, proteases, hemolysins, etc. In addition to fimbriae and pili, the adhesive properties of B. pseudomallei are supposed to be associated with surface capsule-like structures whose composition includes Ag8. The characterization of exoproteases, hemolysins and lethal toxins is given. The virulence and immunogenicity of B. pseudomallei were shown to be linked with the components of surface glycoprotein Ag8. The conclusion has been made that the analyzed pathogenicity factors are of importance for deciphering the pathogenesis of melioidosis.
Piven'
N N
NN
Research Institute for Plague Control, Volgograd, Russia.
Iliukhin
V I
VI
D000818:Animals; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D016957:Burkholderia pseudomallei / Q000276:immunology / Q000472:pathogenicity*
D000942:Antigens, Bacterial; D000954:Antigens, Surface
Patogennost' Burkholderia pseudomallei kak funktsiia vnekletochnykh i poverkhnostnykh antigenov.