title: Muscle strength, functional mobility and vitamin D in older women.
abstract: Vitamin D deficiency may lead to loss of type II muscle fibres, and thereby to atrophy of proximal muscles with an increased risk of falling and bone fractures. The aim of the study was to determine if six months of vitamin D treatment (0.5 microg alphacalcidol) could positively influence values for muscle strength and functional mobility in vitamin D-deficient older women. Twenty-seven women entered the study which took place at a teaching hospital outpatient department. Ten vitamin D-deficient (serum 25(OH)D3 <20 nmol/L) older (>70 years) women and 13 age-matched female subjects with normal vitamin D levels (serum 25(OH)D3 >30 nmol/L) completed the study. Preand post-treatment data were obtained for isometric knee extensor strength, handgrip strength and functional mobility (walking distance over 2 minutes and the timed i'Up & Go" test). Six months of treatment with alphacalcidol led to significant improvements (compared to the controls) in values of isometric knee extensor strength (left leg: 14.6% +/- 5.7%. p=0.03; right leg: 11.5% +/- 5.0%, p=0.02) (mean +/- SEM). The achievements in the timed "Up & Go" test and 2-minute walking test did not improve in the alphacalcidol group compared to the controls after 6 months. However, within the vitamin D-deficient group, 6 months of alphacalcidol treatment led to a significant increase in the walking distance over 2 minutes (increase from 137.6 +/- 12.6 to 151.3 +/- 11.2 meters, p=0.03). The controls, with normal vitamin D levels, did not exhibit improvements in performance of any of the tests over a period of 6 months. Summarized, alphacalcidol seems to improve muscle strength and walking distance over 2 minutes in vitamin D-deficient older women.
authors.affiliation: Department of Geriatrics, University Medical Center, Utrecht, The Netherlands. h.j.j.verhaar@azu.nl
authors.forename: H J
authors.initials: HJ
authors.lastname: Verhaar
authors.forename: M M
authors.initials: MM
authors.lastname: Samson
authors.forename: P A
authors.initials: PA
authors.lastname: Jansen
authors.forename: P L
authors.initials: PL
authors.lastname: de Vreede
authors.forename: J W
authors.initials: JW
authors.lastname: Manten
authors.forename: S A
authors.initials: SA
authors.lastname: Duursma
mesh_terms: D000368:Aged; D005260:Female; D018737:Hand Strength; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D007537:Isometric Contraction / Q000187:drug effects; D007717:Knee; D009043:Motor Activity / Q000187:drug effects*; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000503:physiopathology*; D012016:Reference Values; D013997:Time Factors; D014808:Vitamin D Deficiency / Q000188:drug therapy* / Q000503:physiopathology*; D016138:Walking
chemical_list: D006887:Hydroxycholecalciferols; C008088:alfacalcidol