[Critical phases of the brain development].
Various effects were shown to act alter the proceeding of histogenetic processes in the embryonic neural tissue. Studies in mice revealed that, depending on the embryogenesis stage when a lack of serotonin occurred, the lack of this monoamine entails either death of the embryo or a teratogenic effect, or underdevelopment of brain structures. In the rat model of a shorten hypoxia, a disorder of neural tissue histogenesis in early stages of development, was found, as well as a reduction of its sensitivity to lack of oxygen by the end of embryogenesis.
Kassil'
V G
VG
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia. Institute of Experimental Medicine of the Russian Acad. Med. Sci., Russia.
Otellin
V A
VA
Khozhaĭ
L I
LI
Kostkin
V B
VB
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000002:abnormalities / Q000196:embryology / Q000254:growth & development*; D020964:Embryo Loss / Q000209:etiology; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications; D005865:Gestational Age; D000860:Hypoxia / Q000150:complications; D018811:Maternal Exposure / Q000009:adverse effects; D012701:Serotonin / Q000172:deficiency
D012701:Serotonin
Kriticheskie periody razvitiia golovnogo mozga.