Autonomic studies in hypertensive patient with unusual sexual dysfunction: response to reserpine.
The authors examined a 48-year-old man with a history of hypertension (6 years) and a history of erection and ejaculation during cold exposure and confrontation with fear (20 years). Exposing the foot to cold water induced ejaculation in 10 seconds. A variety of antihypertensive medications resulted in control of hypertension, without improvement in ejaculatory dysfunction. Similarly, prazosin controlled the blood pressure, but not the episodes of ejaculation. Treatment with reserpine resulted in gradual reduction in blood pressure and an improvement in ejaculatory dysfunction.
Deepak
K K
KK
Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi. kkdeepak@hotmail.com
Bhargava
B
B
Narang
R
R
Paudel
B H
BH
Rai
P K
PK
Saxena
S
S
D001341:Autonomic Nervous System / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D003080:Cold Temperature / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004542:Ejaculation / Q000187:drug effects; D005239:Fear; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000187:drug effects; D011224:Prazosin / Q000627:therapeutic use; D011930:Reaction Time / Q000187:drug effects; D012110:Reserpine / Q000627:therapeutic use*; D012735:Sexual Dysfunction, Physiological / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D016896:Treatment Outcome; D014636:Valsalva Maneuver
D012110:Reserpine; D011224:Prazosin