title: [Results of the multicenter controlled study of the hypolipidemic drug polycosanol in Russia].
abstract: OBJECTIVE
  To compare efficacy and tolerance of polycosanol vs besafibrate in patients with hypercholesterolemia (HCE).
  
  
  METHODS
  A multicenter controlled double blind randomised trial entered 113 patients with HCE. After 5 weeks of diet the patients were randomised into two groups. 59 patients of group 1 received polycosanol (10 mg/day), 54 patients of group 2 were given besafibrate (400 mg/day) for 8 weeks.
  
  
  RESULTS
  The 8-week course of treatment was completed by 103 patients (91%): 57(97%) patients of group 1 and 46(85%) patients of group 2. In group 1 total cholesterol diminished by an average of 15%, LDLP cholesterol fell by 18%, triglycerides by 15%, while in group 2 a respective decrease was 8, 11 and 6%. Side effects in group 1 were mild.
  
  
  CONCLUSIONS
  A hypolipidemic effect of polycosanol in a daily dose 10 mg is superior to that of besafibrate in a daily dose 400 mg.
authors.forename: Iu P
authors.initials: IuP
authors.lastname: Nikitin
authors.forename: N V
authors.initials: NV
authors.lastname: Slepchenko
authors.forename: N A
authors.initials: NA
authors.lastname: Gratsianskiĭ
authors.forename: A S
authors.initials: AS
authors.lastname: Nechaev
authors.forename: A L
authors.initials: AL
authors.lastname: Syrkin
authors.forename: M G
authors.initials: MG
authors.lastname: Poltavskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Sumarokov
authors.forename: A V
authors.initials: AV
authors.lastname: Revazov
mesh_terms: D004311:Double-Blind Method; D005233:Fatty Alcohols / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012426:Russia
chemical_list: D005233:Fatty Alcohols; D000960:Hypolipidemic Agents; C044309:1-octacosanol
vernacular_title: Rezul'taty rossiĭskogo mnogotsentrovogo kontroliruemogo issledovaniia gipolipidemicheskogo preparata polikosanol.