title: Pancreatic dysfunction in severe obesity.
abstract: OBJECTIVE
  To investigate pancreatic function in children attending an obesity clinic.
  
  
  METHODS
  Thirty six children (of which 34 were white) with severe obesity of prepubertal onset (body mass index more than +2 SDS) were reviewed clinically and dysmorphologically, with assessment of pancreatic function.
  
  
  RESULTS
  Eight had dysmorphic features and 13 had learning difficulties. Four of 17 prepubertal children had hyperinsulinaemia and seven had hyperproinsulinaemia. All 19 pubertal children had hyperinsulinaemia, 14 had hyperproinsulinaemia, and one had type II diabetes.
  
  
  CONCLUSIONS
  Metabolic abnormalities predictive of type II diabetes occur in severely obese white children.
authors.affiliation: The Royal Hospital for Sick Children, St Michael's Hill, Bristol BS2 8BJ, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Drake
authors.forename: L
authors.initials: L
authors.lastname: Greenhalgh
authors.forename: R
authors.initials: R
authors.lastname: Newbury-Ecob
authors.forename: E C
authors.initials: EC
authors.lastname: Crowne
authors.forename: J P
authors.initials: JP
authors.lastname: Shield
mesh_terms: D000293:Adolescent; D015992:Body Mass Index; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000209:etiology / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology; D008297:Male; D009765:Obesity; D009767:Obesity, Morbid / Q000150:complications / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism*; D010186:Pancreatic Function Tests; D011237:Predictive Value of Tests; D011629:Puberty, Precocious / Q000209:etiology / Q000378:metabolism; D012307:Risk Factors