title: Constitutively raised serum concentrations of mast-cell tryptase and severe anaphylactic reactions to Hymenoptera stings.
abstract: Anaphylactic IgE-mediated reactions to Hymenoptera stings vary in their severity for reasons that are not clear. We investigated patients with a history of systemic anaphylatic reactions to honeybee or wasp stings. Nine (75%) of 12 patients with raised tryptase concentrations but only 28 (28%) of 102 patients with lower tryptase concentrations, had a history of severe sting reactions (p=0.004). Raised baseline serum concentrations of mast-cell tryptase and mastocytosis are potential risk factors for severe allergic reactions to Hymenoptera venom.
authors.forename: D
authors.initials: D
authors.lastname: Ludolph-Hauser
authors.forename: F
authors.initials: F
authors.lastname: Ruëff
authors.forename: C
authors.initials: C
authors.lastname: Fries
authors.forename: P
authors.initials: P
authors.lastname: Schöpf
authors.forename: B
authors.initials: B
authors.lastname: Przybilla
mesh_terms: D000328:Adult; D000368:Aged; D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006927:Hymenoptera; D018836:Inflammation Mediators / Q000097:blood* / Q000276:immunology; D007299:Insect Bites and Stings / Q000276:immunology*; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D012697:Serine Endopeptidases / Q000097:blood* / Q000276:immunology; D053802:Tryptases
chemical_list: D018836:Inflammation Mediators; D012697:Serine Endopeptidases; D053802:Tryptases