title: Anatomical risk factors for phonological dyslexia.
abstract: Successful behavioral genetic studies require precise definition of a homogenous phenotype. This study searched for anatomical markers that might restrict variability in the reading disability phenotype. The subjects were 15 college students (8 male/7 female) diagnosed with a reading disability (RD) and 15 controls (8 males/7 females). All subjects completed a cognitive and reading battery. Only 11 of the RD subjects had a phonological deficit [phonological dyslexia (PD): pseudo word decoding scores < 90 (27th percentile)]. Thirteen RD (9 PD) and 15 controls received a volumetric MRI scan. Four anatomical measures differentiated the PD group from the remainder of the subjects: (i) marked rightward cerebral asymmetry, (ii) marked leftward asymmetry of the anterior lobe of the cerebellum, (ii) combined leftward asymmetry of the planum and posterior ascending ramus of the sylvian fissure, and (iv) a large duplication of Heschl's gyrus on the left. When these four measures were normalized and summed, the resulting variable predicted short- and long-term phonological memory. By contrast, oral and written comprehension skills were predicted by a different anatomical variable: low cerebral volume. These findings provide neurobiological support for an RD phenotype characterized by phonological deficits in the presence of normal or superior comprehension. The study of individual variation in cortical structure may provide a useful link between genotype and behavior.
authors.affiliation: Department of Neuroscience, University of Florida Brain Institute, Gainesville, FL 32611, USA. leonard@ufbi.ufl.edu
authors.forename: C M
authors.initials: CM
authors.lastname: Leonard
authors.forename: M A
authors.initials: MA
authors.lastname: Eckert
authors.forename: L J
authors.initials: LJ
authors.lastname: Lombardino
authors.forename: T
authors.initials: T
authors.lastname: Oakland
authors.forename: J
authors.initials: J
authors.lastname: Kranzler
authors.forename: C M
authors.initials: CM
authors.lastname: Mohr
authors.forename: W M
authors.initials: WM
authors.lastname: King
authors.forename: A
authors.initials: A
authors.lastname: Freeman
mesh_terms: D000328:Adult; D001303:Auditory Cortex / Q000473:pathology*; D002531:Cerebellum / Q000473:pathology; D004410:Dyslexia / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010700:Phonetics; D011237:Predictive Value of Tests; D012307:Risk Factors