[Monoclonal antibodies as an instrument to study fibrin polymerization].
Examples of using monoclonal antibodies (MAb) for studying the fibrin polymerization mechanism are considered. MAb with epitopes situated in the fibrin polymerization sites or in the recognition sites of enzymes thrombin, plasminogen, and factor XIII, which are the functional partners of fibrin, are primarily discussed. The MAb to epitopes in various regions of A alpha, B beta, and gamma polypeptide chains of the functionally important E, D, and alpha C domains of fibrin are successively described.
Lugovskoĭ
E V
EV
Palladin Institute of Biochemistry, National Academy of Sciences of Ukraine, ul. Leontovicha 9, Kiev, 01601 Ukraine.
Komisarenko
S V
SV
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000276:immunology*; D001665:Binding Sites; D001704:Biopolymers; D000939:Epitopes / Q000276:immunology; D005337:Fibrin / Q000276:immunology / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D001704:Biopolymers; D000939:Epitopes; D005337:Fibrin
Monoklonal'nye antitela kak instrument issledovaniia polimerizatsii fibrina.