[Cytotoxic and cytostatic effect of avermectines on tumor cells in vitro].
Effect of natural avermectin complex (aversectin C) and separate avermectins A1, A2, B1 and B2 in the cell culture of murine myeloma Ns/o, Erlich carcinoma ascites and human larynx carcinoma Hep-2 was investigated. It was shown that aversectin C within the concentrations of 0.1 to 1.0 mcg/ml inhibited proliferation of tumor cells and induced their death. Proliferation inhibition was due to the delay of the cells cycle start (lag-phase prolongation) and blocking of mitotic cycle. Ns/o cells death had apoptosis signs: chromatin condensation and fragmentation, DNA fragmentation. It was demonstrated that only avermectin A1 has cytotoxic activity within the concentrations used, avermectins A2 and B2 had cytostatic activity, avermectin B1 showed no activity under the experimental conditions.
Mosin
V A
VA
Research Biological Centre Pharmbiomed, Moscow.
Krugliak
E B
EB
Sterlina
T S
TS
Korystov
Iu N
IuN
Shaposhnikova
V V
VV
Narimanov
A A
AA
Kublik
L N
LN
Levitman
M Kh
MKh
Viktorov
A V
AV
Driniaev
V A
VA
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007822:Laryngeal Neoplasms; D051379:Mice; D009101:Multiple Myeloma; D009375:Neoplasms, Glandular and Epithelial; D014407:Tumor Cells, Cultured
D000903:Antibiotics, Antineoplastic; C048324:abamectin; D007559:Ivermectin; C019264:avermectin
[Tsitostaticheskoe i tsitotoksicheskoe deĭstvie avermektinov na opukholevye kletki in vitro]