Tetanus-like syndrome secondary to metoclopramide administration.
A case of metoclopramide-induced pseudotetanus in a 24-year-old woman is described. Symptoms included flexor spasms of the neck muscles, neck pain, left deviation of the lower jaw and tongue protrusion. Tetanus was initially suspected. Mydriasis, hyperhydrosis and clinical observation indicated that this syndrome could be caused by metoclopramide taken for gastrointestinal symptoms. Orphenadrine hydrochloride, diazepam and ketoprofen completely resolved the symptoms. Pseudotetanus presents in many different ways, and it is sometimes very hard to distinguish it from infective tetanus, which is very difficult to diagnose. Physicians using metoclopramide should be aware of its adverse effects and how to treat them.
Mazza
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A
Clinica Medica 4, Dipartimento di Medicina Clinica e Sperimentale, Università degli Studi di Padova.
Ruffatti
S
S
Pessina
A C
AC
Casiglia
E
E
D000328:Adult; D000932:Antiemetics / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007568:Jaw; D008787:Metoclopramide / Q000009:adverse effects*; D009334:Neck Muscles / Q000187:drug effects*; D013035:Spasm / Q000139:chemically induced* / Q000175:diagnosis / Q000188:drug therapy; D013742:Tetanus / Q000175:diagnosis; D014060:Tongue Diseases / Q000139:chemically induced / Q000188:drug therapy
D000932:Antiemetics; D008787:Metoclopramide