[Effect of age on frequency of heteroploidy in human oocytes].
Human oocytes that failed to be fertilized in vitro were fixed for cytogenetic analysis. Successful karyotyping was achieved in 157 oocytes. Among women aged 23-35 years, 34% of oocytes were aneuploid and 8.6% diploid, while for women aged 36-39 years, these values exceeded 41 and 11.8%, respectively. The proportion of aneuploid and diploid oocytes increased significantly as the maternal age advanced. The rate of chromosomal abnormalities with age was analysed using methods of mathematical modelling.
Vorob'eva
O A
OA
Ott Institute of Obstetrics and Gynecology RAMN, St. Petersburg.
Bogomolova
M V
MV
Kuznetsova
T V
TV
Kozlov
V V
VV
D000328:Adult; D005260:Female; D006801:Humans; D007621:Karyotyping; D008423:Maternal Age; D009865:Oocytes / Q000648:ultrastructure*; D011003:Ploidies
Vliianie vozrasta na chastotu geteroploidii v ootsitakh cheloveka.