title: Preference between onset predictable and unpredictable administrations of 20% carbon-dioxide-enriched air: implications for better understanding the etiology and treatment of panic disorder.
abstract: Predictability of aversive events impacts the development and maintenance of anxiety, particularly panic disorder. Although animal studies typically have found a preference for signaled (predictable) over unsignaled (unpredictable) aversive events, results of research with human participants have been less clear. Using a panic-relevant paradigm, the authors examined predictability preference with humans as a function of anxiety sensitivity and gender during repeated administrations of 20% carbon-dioxide-enriched air. Participants preferred predictable administrations, with high-anxiety individuals showing greater preference than low-anxiety individuals and women showing greater preference than men. In addition to providing information to better understand human predictability preference for panic-related events, results also may aid in determining the applicability of predictability to the cognitive-behavioral treatment of panic disorder.
authors.affiliation: Department of Psychology, West Virginia University, USA. carl_lejuez@brown.edu
authors.forename: C W
authors.initials: CW
authors.lastname: Lejuez
authors.forename: G H
authors.initials: GH
authors.lastname: Eifert
authors.forename: M J
authors.initials: MJ
authors.lastname: Zvolensky
authors.forename: J B
authors.initials: JB
authors.lastname: Richards
mesh_terms: D000293:Adolescent; D000328:Adult; D001143:Arousal / Q000187:drug effects; D001245:Association Learning / Q000187:drug effects*; D002245:Carbon Dioxide; D002755:Choice Behavior; D015928:Cognitive Behavioral Therapy; D003214:Conditioning, Classical / Q000187:drug effects; D005260:Female; D006801:Humans; D007206:Individuality; D007389:Internal-External Control; D008297:Male; D010200:Panic / Q000187:drug effects*; D016584:Panic Disorder / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: D002245:Carbon Dioxide