title: Targeting tumor vasculature using VEGF-toxin conjugates.
authors.affiliation: Department of Pharmacology, University of Minnesota, Minneapolis, MN, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ramakrishnan
authors.forename: R
authors.initials: R
authors.lastname: Wild
authors.forename: D
authors.initials: D
authors.lastname: Nojima
mesh_terms: D020533:Angiogenesis Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D042501:Angiogenic Proteins; D000818:Animals; D002460:Cell Line / Q000187:drug effects; D002642:Chick Embryo; D003094:Collagen; D003432:Cross-Linking Reagents; D019281:Dimerization; D004167:Diphtheria Toxin / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D004338:Drug Combinations; D015195:Drug Design; D016228:Endothelial Growth Factors / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use*; D004730:Endothelium, Vascular / Q000166:cytology; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D007797:Laminin; D008222:Lymphokines / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification / Q000494:pharmacology / Q000502:physiology / Q000627:therapeutic use*; D051379:Mice; D008819:Mice, Nude; D008958:Models, Molecular; D017510:Protein Folding; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D011509:Proteoglycans; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D017978:Receptors, Growth Factor / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use; D014407:Tumor Cells, Cultured; D014471:Umbilical Veins / Q000166:cytology; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D042442:Vascular Endothelial Growth Factors; D023041:Xenograft Model Antitumor Assays
chemical_list: D020533:Angiogenesis Inhibitors; D042501:Angiogenic Proteins; D003432:Cross-Linking Reagents; D004167:Diphtheria Toxin; D004338:Drug Combinations; D016228:Endothelial Growth Factors; D007797:Laminin; D008222:Lymphokines; D020033:Protein Isoforms; D011509:Proteoglycans; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor; D011993:Recombinant Fusion Proteins; C414842:VEGF121-diphtheria toxin conjugate; C467484:VEGFA protein, human; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C059485:matrigel; D003094:Collagen; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor; D040281:Vascular Endothelial Growth Factor Receptor-1