title: Multiple ovarian biopsy in the treatment of women with polycystic ovary syndrome (PCOS).
abstract: BACKGROUND
  Ovarian electrocautery has been used with success in the treatment of PCOS women. However, unipolar coagulation carries the risk of serious injuries to pelvic organs. In an effort to avoid this potential risk, the efficacy of multiple ovarian biopsy was evaluated in our study.
  
  
  METHODS
  Eleven PCOS patients were enrolled to the study. Four to eight biopsies were taken from both ovaries. The levels of LH, FSH, androgens and the reactivity of ACTH test were evaluated at standard intervals. The occurrence of ovulation was determined by ultrasound.
  
  
  RESULTS
  Laparoscopy was followed by non-significant changes of endocrine parameters only. The ovulatory cycle was restored in only three women of the whole group.
  
  
  CONCLUSIONS
  Our study did not prove the efficacy of multiple ovarian biopsy in the treatment of PCOS women. The procedure caused only minor changes in endocrine parameters and rarely restored ovulation.
authors.affiliation: Department of Obstetrics and Gynecology, General Teaching Hospital, Charles University, Prague Institute of Endocrinology, Czech Republic.
authors.forename: D
authors.initials: D
authors.lastname: Cibula
authors.forename: D
authors.initials: D
authors.lastname: Kuzel
authors.forename: K
authors.initials: K
authors.lastname: Rezabek
authors.forename: J
authors.initials: J
authors.lastname: Vrbikova
authors.forename: J
authors.initials: J
authors.lastname: Zivny
authors.forename: P L
authors.initials: PL
authors.lastname: Starka
mesh_terms: D019326:17-alpha-Hydroxyprogesterone / Q000097:blood; D000324:Adrenocorticotropic Hormone; D001706:Biopsy; D003687:Dehydroepiandrosterone / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010053:Ovary / Q000000981:diagnostic imaging / Q000601:surgery*; D010060:Ovulation; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000601:surgery*; D011247:Pregnancy; D011446:Prospective Studies; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D013739:Testosterone / Q000097:blood; D014463:Ultrasonography
chemical_list: D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D003687:Dehydroepiandrosterone; D019326:17-alpha-Hydroxyprogesterone; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone