Amelioration of fluoride-induced hypocalcaemia by vitamins.
Oral administration of sodium fluoride (40 mg/kg body weight) from day 6 of gestation to day 21 of lactation caused, compared with vehicle control, significantly lowered level of calcium and phosphorus in the serum of both P and F1 generation rats. Administration of vitamin C (50 mg/kg body weight), D (2 ng/0.2 ml olive oil/animal), E (2 mg/0.2 ml olive oil/animal) and a combination (vitamin C + D + E) along with NaF caused significant amelioration in serum calcium in P generation and serum phosphorus in both P and F1 generation rats as compared with only NaF-treated group. Serum calcium concentration was only partially recovered (P and F1 generation) on NaF withdrawal during lactation, as well as, on cotreatment (F1 generation) with vitamins. However, serum phosphorus level was significantly recovered on NaF withdrawal.
Guna Sherlin
D M
DM
Jai Research Foundation, Valvada, India.
Verma
R J
RJ
D000818:Animals; D000831:Animals, Newborn; D000833:Animals, Suckling; D001205:Ascorbic Acid / Q000008:administration & dosage*; D002118:Calcium / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D006996:Hypocalcemia / Q000188:drug therapy*; D007774:Lactation / Q000187:drug effects; D008297:Male; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D012969:Sodium Fluoride / Q000633:toxicity*; D014807:Vitamin D / Q000008:administration & dosage*; D014810:Vitamin E / Q000008:administration & dosage*
D014807:Vitamin D; D014810:Vitamin E; D010758:Phosphorus; D012969:Sodium Fluoride; D001205:Ascorbic Acid; D002118:Calcium