title: Cytogenetic and andrological status and ICSI-results in couples with severe male factor infertility.
abstract: OBJECTIVE
  To pursue whether cytogenetic aberrations correlate with specific spermatological or hormonal abnormalities.
  
  
  METHODS
  305 infertile couples were investigated. All male partners were referred to a complete andrological work-up with physical examination, determination of hormones, HIV testing and semen analysis. Cytogenetic analysis was carried out in both partners by means of standard techniques using cultured lymphocytes from peripheral blood.
  
  
  RESULTS
  Among the 305 couples, 10 men (3.2%) and 10 women (3.2%) showed constitutional chromosomal aberrations, including reciprocal translocations (n = 7), Robertsonian translocations (n = 3), inversions (n = 3), other structural aberrations (n = 4) and sex chromosome aberration (n = 3). In addition to the impaired sperm count in most of the patients, a tendency to an increased proportion of spermatozoa with acrosome defect was observed.
  
  
  CONCLUSIONS
  Chromosomal aberrations may contribute to the low fertilization and pregnancy rates in the infertile couples.
authors.affiliation: Dept. of Dermatology and Andrology, University of Bonn, 53105, Bonn, Germany. gerhand.haidl@meb.uni-bonn.de
authors.forename: G
authors.initials: G
authors.lastname: Haidl
authors.forename: B
authors.initials: B
authors.lastname: Peschka
authors.forename: G
authors.initials: G
authors.lastname: Schwanitz
authors.forename: M
authors.initials: M
authors.lastname: Montag
authors.forename: K
authors.initials: K
authors.lastname: van der Ven
authors.forename: H
authors.initials: H
authors.lastname: van der Ven
mesh_terms: D002869:Chromosome Aberrations / Q000235:genetics*; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000235:genetics* / Q000473:pathology*; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D018873:Pregnancy Rate; D013076:Sperm Count; D020554:Sperm Injections, Intracytoplasmic; D013081:Sperm Motility / Q000235:genetics; D013094:Spermatozoa / Q000473:pathology*