Pharmacokinetic studies of cyclosporin in Thai kidney transplantation patients.
Pharmacokinetic studies were performed in 10 Thai patients with kidney transplantation who received microemulsion formulation (Neoral) of cyclosporin A (CsA) twice daily. No agents having pharmacokinetic effect on CsA had been used in these patients. The mean values of 12-h AUC (area under the concentration-blood curve) were 4603.63 +/- 344.61 ng x h/ml. CsA concentrations at 2 hours after dosing had the best value of correlation coefficient with the 12-h AUC. Abbreviated AUC could be calculated by stepwise multiple linear regression analysis and linear trapezoidal rule. The latter is more simple and superior to the former one.
Kungsamrith
T
T
Department of Pharmacy, Faculty of Pharmaceutical Science, Chulalongkorn University, Bangkok, Thailand.
Eiam-Ong
S
S
Avihingsanon
Y
Y
Tungsanga
K
K
Chusil
S
S
Ayudhya
D P
DP
D000328:Adult; D000368:Aged; D019540:Area Under Curve; D016572:Cyclosporine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D016030:Kidney Transplantation / Q000502:physiology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D013785:Thailand
D007166:Immunosuppressive Agents; D016572:Cyclosporine