title: Tumor necrosis factor receptor superfamily 12 may destabilize atherosclerotic plaques by inducing matrix metalloproteinases.
abstract: Immunohistochemical staining of human atherosclerotic plaques revealed expression of the tumor necrosis factor receptor superfamily (TNFRSF) 12 in regions rich in macrophage/foam cells. The role of TNFRSF12 in the functioning of monocytes in relation to atherogenesis was investigated by analysis of cellular events after stimulation of TNFRSF12 in a human macrophage-like cell line, THP-1. Activation of the THP-1 cells on plates coated with monoclonal antibody against TNFRSF12 induced the expression of matrix metalloproteinases (MMPs) -1, -9, and -13. Furthermore, the expression patterns of TNFRSF12 and the MMPs overlapped in atherosclerotic plaques. Signaling of TNFRSF12 may thus contribute to the induction of extracellular matrix degrading enzymes in macrophages.
authors.affiliation: Cardiology Division, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: S H
authors.initials: SH
authors.lastname: Kim
authors.forename: W H
authors.initials: WH
authors.lastname: Lee
authors.forename: B S
authors.initials: BS
authors.lastname: Kwon
authors.forename: G T
authors.initials: GT
authors.lastname: Oh
authors.forename: Y H
authors.initials: YH
authors.lastname: Choi
authors.forename: J E
authors.initials: JE
authors.lastname: Park
mesh_terms: D001161:Arteriosclerosis / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D020782:Matrix Metalloproteinases / Q000096:biosynthesis*; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*
chemical_list: D018124:Receptors, Tumor Necrosis Factor; D020782:Matrix Metalloproteinases