Synthesis of N-labeled peptidyl AMP.
This paper deals with the synthesis of a new type of N-labeled peptidyl AMP, which would be used as a good substrate for analysis of the peptidyl transfer reaction on ribosome and for co-crystallization with ribosome. 4-(Dimethylamino)azobenzene-4'-sulfonyl (Dabsyl) was selected as the labeling group. (N-Dabsylglycyl)-L-leucyl AMP was synthesized from glycyl-L-leucine via a three-step procedure.
Narita
H
H
Department of Biophysics and Biochemistry, Graduate School of Science, University of Tokyo, Japan.
Moriguchi
T
T
Seio
K
K
Sekine
M
M
Miyaguchi
H
H
Sakamoto
K
K
Yokoyama
S
S
D000249:Adenosine Monophosphate / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D013057:Spectrum Analysis
D010455:Peptides; D000249:Adenosine Monophosphate