title: A novel anti-HBeAg homolignan, taiwanschirin D from Kadsura matsudai.
abstract: A novel C19 homolignan, taiwanschirin D (1), possessing a 3,4-(1-[(Z)-2-methoxy-2-oxoethylidenel)pentano (2,3-dihydrobenzo[b]furan)-3(2-oxoacetate) skeleton, was isolated from the stem of Kadsura matsudai Hayata. Its structure was determined from physical and spectral data including 2D NMR spectra. The Anti-HBeAg test revealed that taiwanschirin D (1) had moderate activity at a concentration of 94.3 microM (50 microg/ml).
authors.affiliation: National Research Institute of Chinese Medicine, Shih-Pai, Taipei 112, Taiwan.
authors.forename: S Y
authors.initials: SY
authors.lastname: Li
authors.forename: M D
authors.initials: MD
authors.lastname: Wu
authors.forename: C W
authors.initials: CW
authors.lastname: Wang
authors.forename: Y H
authors.initials: YH
authors.lastname: Kuo
authors.forename: R L
authors.initials: RL
authors.lastname: Huang
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells; D006515:Hepatitis B virus / Q000187:drug effects; D006801:Humans; D007624:KB Cells; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D017705:Lignans; C423472:taiwanschirin D