An IL-13 promoter polymorphism associated with increased risk of allergic asthma.
IL-13 plays a crucial role in the development of allergic asthma by several mechanisms, including induction of IgE antibodies, airway eosinophilia and hyper-reactivity. We previously established a deregulated production of IL-13 by T cells from allergic asthma patients. In this report we describe the identification of a novel IL-13 promoter polymorphism (C to T exchange) at position -1055. The IL-13 -1055 TT genotype is associated with allergic asthma (P = 0.002), altered regulation of IL-13 production (P < 0.002), and increased binding of nuclear proteins to this region. We postulate that the presence of this polymorphism predisposes to the development of allergic asthma.
van der Pouw Kraan
T C
TC
Department of Auto-Immune Diseases, CLB and Laboratory of Clinical and Experimental Immunology, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands.
van Veen
A
A
Boeije
L C
LC
van Tuyl
S A
SA
de Groot
E R
ER
Stapel
S O
SO
Bakker
A
A
Verweij
C L
CL
Aarden
L A
LA
van der Zee
J S
JS
D001249:Asthma / Q000235:genetics* / Q000276:immunology*; D001483:Base Sequence; D016022:Case-Control Studies; D004247:DNA / Q000235:genetics; D017931:DNA Primers / Q000235:genetics; D005838:Genotype; D006801:Humans; D018793:Interleukin-13 / Q000096:biosynthesis / Q000235:genetics*; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D012307:Risk Factors
D017931:DNA Primers; D018793:Interleukin-13; D004247:DNA