[External signals can induce stable increase in frequency of cell death in populations].
Relatively weak radiation and some other external actions, producing no "forced" cell death, trigger some intracellular mechanisms in various unicellular organisms (amoebae, ciliates, yeasts) and in the studied mammalian cells (rat vascular endotheliocytes). These mechanisms provide spasmodic changes: massive transition of cell populations into a stationary alternative state which is characterized by an increased predisposition to cell death, in comparison with the initial level. This phenomenon is considered as a particular, widely spread in nature form of genetic control of cell death frequency populations.
Bychkovskaia
I B
IB
All-Russian Centre of Emergency and Radiation Medicine, Emercom of Russia.
Stepanov
R P
RP
Fedortseva
R F
RF
D000818:Animals; D016923:Cell Death / Q000187:drug effects / Q000528:radiation effects; D013696:Temperature
Vneshnie signaly mogut indutsirovat' ustoĭchivoe povyshenie chastoty gibeli kletok v populiatsiiakh.