Aging increases, and duodenal ulcer reduces the risk for intestinal metaplasia of the gastric corpus in Japanese patients with dyspepsia.
OBJECTIVE
The classification of gastritis by using the revised Sydney system suggests that there are two types of Helicobacter pylori-related gastritis. The aim of the present study was to examine the risk factors that might be involved in the presence of either atrophic gastritis or intestinal metaplasia of the gastric corpus of Japanese patients.


METHODS
Biopsy samples were obtained from the gastric corpus in 154 patients with dyspepsia, and the degree of atrophy or intestinal metaplasia was determined histologically. The correlation between several variables and presence of atrophy or intestinal metaplasia was evaluated by using multivariate analysis.


RESULTS
Among the 11 variables, which included age, peptic ulcer diseases and H. pylori infection, H. pylori infection was the major risk factor associated with the presence of atrophic gastritis or intestinal metaplasia of the gastric corpus. In contrast, duodenal ulcer (DU) disease reduced the risk of contracting both conditions. Age was an independent risk factor only for intestinal metaplasia of the gastric corpus. When 128 H. pylori-positive subjects were analyzed, DU and age were similarly associated with the presence of both conditions.


CONCLUSIONS
These results suggest that DU reduces the risk for contracting atrophic gastritis and intestinal metaplasia, and age is an independent risk factor for intestinal metaplasia of the gastric corpus in dyspeptic Japanese patients.
Tsukui
T
T
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Kashiwagi
R
R
Sakane
M
M
Tabata
F
F
Akamatsu
T
T
Wada
K
K
Futagami
S
S
Miyake
K
K
Sueoka
N
N
Hirakawa
T
T
Kobayashi
M
M
Fujimori
T
T
Sakamoto
C
C
D000328:Adult; D000367:Age Factors; D000368:Aged; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D004381:Duodenal Ulcer / Q000150:complications / Q000382:microbiology / Q000473:pathology*; D004415:Dyspepsia / Q000209:etiology / Q000473:pathology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005757:Gastritis, Atrophic / Q000150:complications / Q000473:pathology*; D005773:Gastroscopy; D016481:Helicobacter Infections / Q000150:complications / Q000473:pathology*; D016480:Helicobacter pylori; D006801:Humans; D007564:Japan; D016015:Logistic Models; D008297:Male; D008679:Metaplasia; D008875:Middle Aged; D011446:Prospective Studies; D011863:Radioimmunoassay; D012307:Risk Factors