title: [Effect of age on frequency of heteroploidy in human oocytes].
abstract: Human oocytes that failed to be fertilized in vitro were fixed for cytogenetic analysis. Successful karyotyping was achieved in 157 oocytes. Among women aged 23-35 years, 34% of oocytes were aneuploid and 8.6% diploid, while for women aged 36-39 years, these values exceeded 41 and 11.8%, respectively. The proportion of aneuploid and diploid oocytes increased significantly as the maternal age advanced. The rate of chromosomal abnormalities with age was analysed using methods of mathematical modelling.
authors.affiliation: Ott Institute of Obstetrics and Gynecology RAMN, St. Petersburg.
authors.forename: O A
authors.initials: OA
authors.lastname: Vorob'eva
authors.forename: M V
authors.initials: MV
authors.lastname: Bogomolova
authors.forename: T V
authors.initials: TV
authors.lastname: Kuznetsova
authors.forename: V V
authors.initials: VV
authors.lastname: Kozlov
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007621:Karyotyping; D008423:Maternal Age; D009865:Oocytes / Q000648:ultrastructure*; D011003:Ploidies
vernacular_title: Vliianie vozrasta na chastotu geteroploidii v ootsitakh cheloveka.