title: The preprotein translocase of the outer mitochondrial membrane: receptors and a general import pore.
abstract: Cytosol-synthesized preproteins destined for the mitochondria are transported across the outer membrane by the translocase of the mitochondrial outer membrane (TOM complex). This dynamic transport machinery can be divided into receptors that recognize preprotein targeting signals and components of the general import pore complex that mediate preprotein transport across the outer membrane. This review focuses on recent studies dealing with the central questions regarding the pore-forming subunits, and architecture and gating of the translocation channel of the outer membrane.
authors.affiliation: Institut für Biochemie und Molekularbiologie, Universität Freiburg, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Meisinger
authors.forename: J
authors.initials: J
authors.lastname: Brix
authors.forename: K
authors.initials: K
authors.lastname: Model
authors.forename: N
authors.initials: N
authors.lastname: Pfanner
authors.forename: M T
authors.initials: MT
authors.lastname: Ryan
mesh_terms: D000251:Adenosine Triphosphatases / Q000737:chemistry / Q000378:metabolism*; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D029968:Escherichia coli Proteins; D005658:Fungi / Q000166:cytology / Q000201:enzymology / Q000378:metabolism; D007425:Intracellular Membranes / Q000201:enzymology / Q000378:metabolism*; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D026901:Membrane Transport Proteins; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism*; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D010539:Permeability; D021122:Protein Subunits; D021381:Protein Transport; D000069816:SEC Translocation Channels; D000081416:SecA Proteins
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D046911:Macromolecular Substances; D008565:Membrane Proteins; D026901:Membrane Transport Proteins; D000090622:Mitochondrial Precursor Protein Import Complex Proteins; D021122:Protein Subunits; D000069816:SEC Translocation Channels; D000251:Adenosine Triphosphatases; D000081416:SecA Proteins