title: Solid-phase synthesis of pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones.
abstract: The solid-phase synthesis of biologically important pyrrolo[2,1-c][1,4]benzodiazepine-5,11-diones using Wang resin through amide formation and reductive cyclization procedures is described. Further, N10-substituents have been introduced in the final products and these have been cleaved from the solid support in good yields.
authors.affiliation: Division of Organic Chemistry, Indian Institute of Chemical Technology, Hyderabad, India. ahmedkamal@iict.ap.nic.in
authors.forename: A
authors.initials: A
authors.lastname: Kamal
authors.forename: G S
authors.initials: GS
authors.lastname: Reddy
authors.forename: S
authors.initials: S
authors.lastname: Raghavan
mesh_terms: D014151:Anti-Anxiety Agents / Q000138:chemical synthesis; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D012116:Resins, Plant / Q000737:chemistry; D013388:Succinimides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D014151:Anti-Anxiety Agents; D000903:Antibiotics, Antineoplastic; D012116:Resins, Plant; D013388:Succinimides; D001569:Benzodiazepines