Linkage analysis of a complex pedigree with severe bipolar disorder, using a Markov chain Monte Carlo method.
Recently developed algorithms permit nonparametric linkage analysis of large, complex pedigrees with multiple inbreeding loops. We have used one such algorithm, implemented in the package SimWalk2, to reanalyze previously published genome-screen data from a Costa Rican kindred segregating for severe bipolar disorder. Our results are consistent with previous linkage findings on chromosome 18 and suggest a new locus on chromosome 5 that was not identified using traditional linkage analysis.
Garner
C
C
Department of Integrative Biology, University of California Berkeley, Berkeley, CA 90095-1761, USA.
McInnes
L A
LA
Service
S K
SK
Spesny
M
M
Fournier
E
E
Leon
P
P
Freimer
N B
NB
D000465:Algorithms; D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping / Q000379:methods* / Q000706:statistics & numerical data; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D003241:Consanguinity; D003364:Costa Rica; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D006239:Haplotypes; D006801:Humans; D008126:Lod Score; D008297:Male; D008390:Markov Chains; D008957:Models, Genetic; D009010:Monte Carlo Method; D010375:Pedigree; D012680:Sensitivity and Specificity; D012984:Software; D018709:Statistics, Nonparametric
D005819:Genetic Markers