title: Menetrier's disease associated with cytomegalovirus infection in a child.
abstract: Menetrier's disease is a rare disease with unknown etiology characterized by protein-losing hypertrophic gastropathy and hypoproteinemia. We report on a 4-year-old boy who presented with a 2-week history of vomiting and periorbital edema. Upper gastrointestinal endoscopy revealed prominent gastric rugae, while pathological examination showed hyperplastic mucosa with proliferation, elongation, and basal cystic dilatation of the gastric glands replaced by mucous-secreting epithelium, confirming the diagnosis of Menetrier's disease. Virus isolation from urine revealed cytomegalovirus (CMV); and CMV immunoglobulin G and immunoglobulin M antibodies were detected in the serum. His condition gradually improved under omeprazole, with complete histological recovery after 3 months.
authors.affiliation: Division of Pediatric Gastroenterology, Chang Gung Children's Hospital, No. 5, Fushing St., Kweishan 333, Taoyuan, Taiwan.
authors.forename: K W
authors.initials: KW
authors.lastname: Chang
authors.forename: S J
authors.initials: SJ
authors.lastname: Lin
authors.forename: C
authors.initials: C
authors.lastname: Hsueh
authors.forename: M S
authors.initials: MS
authors.lastname: Kong
mesh_terms: D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D002675:Child, Preschool; D003586:Cytomegalovirus Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D016099:Endoscopy, Gastrointestinal; D005758:Gastritis, Hypertrophic / Q000473:pathology / Q000821:virology*; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole