Effectiveness of high resolution ECG spectral analysis in discrimination of patients prone to ventricular tachycardia and fibrillation.
BACKGROUND
To improve the diagnostic power of high resolution electrocardiography for discriminating patients at risk of ventricular arrhythmias, new methods based on spectral analysis have been used in recent years. The purpose of this study was to evaluate the effectiveness of these methods for predicting the risk of ventricular tachycardia and ventricular fibrillation in patients after myocardial infarction.


METHODS
High resolution ECG were recorded in 129 post-infarction patients and 23 healthy volunteers. Of the post-infarction patients: 62 presented with ventricular tachycardia, 23 with ventricular fibrillation, while 44 had no clinically relevant arrhythmias. The ECG signals were recorded in three orthogonal X, Y, Z leads and averaged using cross-correlation method. Spectral analysis was performed by fast Fourier transform and the parametric modeling method with autoregressive model. Spectral analysis data were evaluated quantitatively by computing normality factor for FFT and spectral factor for AR.


RESULTS
Both methods were found to be useful for evaluating the risk of arrhythmias. The sensitivity of ventricular tachycardia risk evaluation was higher (81%--FFT, 73%--AR) than that of evaluating the risk of ventricular fibrillation (30%--FFT, 48%--AR). The specificity in post-infarction patients without arrhythmias (93%--FFT, 84%--AR) was as high as that in healthy subjects (96%--FFT, 87%--AR).


CONCLUSIONS
Spectral analysis of HRECG is an effective method for evaluating the risk of VT and VF in patients after myocardial infarction.
Mroczka
T
T
Institute of Biocybernetics and Biomedical Engineering of Polish Academy of Sciences, Warsaw, Poland. roman@hrabia.ibib.waw.pl
Lewandowski
P
P
Maniewski
R
R
Liebert
A
A
Spioch
M
M
Steinbach
K
K
D000328:Adult; D000368:Aged; D001699:Biometry; D016022:Case-Control Studies; D004562:Electrocardiography / Q000379:methods* / Q000706:statistics & numerical data; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012984:Software; D017180:Tachycardia, Ventricular / Q000175:diagnosis* / Q000503:physiopathology; D014693:Ventricular Fibrillation / Q000175:diagnosis* / Q000503:physiopathology; D016277:Ventricular Function, Left