title: Automation of the synthesis of highly concentrated 188Re-MAG3 for intracoronary radiation therapy.
abstract: We have developed an efficient method and an automated synthetic system for the preparation of highly concentrated 188Re-MAG3. Routine production of 188Re-MAG3 for use in intracoronary radiation therapy was performed by compressed air driven semi-automated shielded system. 188Re-MAG3 was prepared with a commercial kit and reducing agents, purified and concentrated by C18 Sep-Pak cartridges to desired radioactivity and volume. Using this automated system, reproducible radiolabeling yields of 80-85% were obtained.
authors.affiliation: Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. sjoh@www.amc.seoul.kr
authors.forename: S J
authors.initials: SJ
authors.lastname: Oh
authors.forename: D H
authors.initials: DH
authors.lastname: Moon
authors.forename: H J
authors.initials: HJ
authors.lastname: Ha
authors.forename: S W
authors.initials: SW
authors.lastname: Park
authors.forename: M K
authors.initials: MK
authors.lastname: Hong
authors.forename: S J
authors.initials: SJ
authors.lastname: Park
authors.forename: T H
authors.initials: TH
authors.lastname: Choi
authors.forename: S M
authors.initials: SM
authors.lastname: Lim
authors.forename: C W
authors.initials: CW
authors.lastname: Choi
authors.forename: F F
authors.initials: FF
authors.lastname: Knapp
authors.forename: H K
authors.initials: HK
authors.lastname: Lee
mesh_terms: D015906:Angioplasty, Balloon, Coronary; D001331:Automation; D003327:Coronary Disease / Q000532:radiotherapy* / Q000628:therapy; D006801:Humans; D008722:Methods; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000627:therapeutic use*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use*; D011868:Radioisotopes / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000627:therapeutic use*; D012211:Rhenium / Q000627:therapeutic use*
chemical_list: D009842:Oligopeptides; D009942:Organometallic Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C114893:rhenium-mercaptoacetyltriglycine; D012211:Rhenium