[Genetic markers of epidemic strains of Vibrio cholerae].
In this review new data on the key pathogenicity genes of V. cholerae are presented. As shown on the basis of the analysis of the latest information on the structure of the genomes of different V. cholerae strains, structural genes ctxAB coding cholera toxin may not serve as the only marker of epidemically dangerous strains. More complete and reliable information for the evaluation of the epidemic potential of V. cholerae isolated from the environment may be obtained by the simultaneous detection of 4 genetic markers: genes ctxAB, tcpA and hap coding, respectively, cholera toxin, toxin-corregulated adhesion pili and soluble hemagglutinin/protease, as well as regulatory virulence gene toxR.
Smirnova
N I
NI
Research Institute for Plaque Control Microbe, Saratov, Russia.
Kirillina
O A
OA
Kutyrev
V V
VV
D002772:Cholera Toxin / Q000235:genetics*; D005798:Genes, Bacterial; D005819:Genetic Markers; D006801:Humans; D014734:Vibrio cholerae / Q000235:genetics* / Q000472:pathogenicity; D014774:Virulence
D005819:Genetic Markers; D002772:Cholera Toxin
Geneticheskie markery épidemicheskikh shtammov Vibrio cholerae.