title: A young female patient with an androgen-secreting tumor: a rare malignant disease.
abstract: A 23-year-old female patient presented with hirsutism and fatigue nine months after delivery. Endocrine assessment showed high testesterone, DHEA-S and androstenedione levels. Abdominal computed tomography and ultrasonography revealed the presence of a large tumor in the right renal region. Right adrenalectomy was performed resulting in a diagnosis of a functional adrenal tumor. Pathological examination showed a steroidogenically active tumor. Adjuvant chemotheraphy was administered postoperatively. At three months following surgery all endocrinological tests normalized, but liver metastases were detected by abdominal CT. Eight months after the operation the patient died of hepatic and renal failure. Androgen-secreting adrenal tumors are seen very rarely, yet the prognosis is poor due to their agressive nature.
authors.affiliation: Department of General Surgery, Medical Faculty, Istanbul University, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Bozbora
authors.forename: Y
authors.initials: Y
authors.lastname: Erbil
authors.forename: N
authors.initials: N
authors.lastname: Ozbey
authors.forename: Y
authors.initials: Y
authors.lastname: Kapran
authors.forename: S
authors.initials: S
authors.lastname: Ozarmagan
authors.forename: E
authors.initials: E
authors.lastname: Berber
authors.forename: S
authors.initials: S
authors.lastname: Molvalilar
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism*; D000315:Adrenalectomy; D000328:Adult; D000728:Androgens / Q000097:blood / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002277:Carcinoma / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism* / Q000601:surgery; D003687:Dehydroepiandrosterone / Q000378:metabolism; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D013739:Testosterone / Q000378:metabolism
chemical_list: D000728:Androgens; D013739:Testosterone; D000735:Androstenedione; D003687:Dehydroepiandrosterone