Nonspecific innate immunity against Escherichia coli infection in chickens induced by vaccine strains of Newcastle disease virus.
The objective was to test the hypothesis that vaccine strains of Newcastle disease virus (NDV) induce nonspecific immunity against subsequent infection with Escherichia coli. White leghorn chickens at 5 wk of age were vaccinated with a NDV vaccine at various days before challenge exposure with O1:K1 strain of E. coli via an intra-air sac route. Immunity was determined on the basis of the viable number of E. coli in the spleen 24 hr after the infection. Roakin strain induced significant (P < 0.05) immunity against E. coli at 4, 6, and 8 days, and La Sota strain at 2, 4, and 8 days, postvaccination. Secondary NDV vaccination administered 14 days later failed to induce immunity against E. coli when chickens were infected 1 or 5 days after the vaccination. Significant (P < 0.05) suppression of this nonspecific immunity was observed in birds treated with corticosterone, 40 mg/kg in feed, given for three consecutive days immediately prior to the bacterial exposure but not in those treated prior to the period. The results indicate that innate immunity induced by the primary NDV vaccination may significantly suppress the multiplication of E. coli in chickens for a period of 2-8 days postvaccination. The NDV-induced immunity was inhibited by corticosterone, which is known to mediate physiological responses to stress.
Huang
H J
HJ
College of Veterinary Medicine, Oregon State University, Corvallis 97331, USA.
Matsumoto
M
M
D000818:Animals; D002645:Chickens; D003345:Corticosterone / Q000494:pharmacology; D004927:Escherichia coli Infections / Q000276:immunology / Q000662:veterinary*; D007109:Immunity / Q000187:drug effects; D008297:Male; D009521:Newcastle Disease / Q000276:immunology; D009522:Newcastle disease virus / Q000276:immunology*; D011201:Poultry Diseases / Q000276:immunology* / Q000517:prevention & control; D014611:Vaccination / Q000662:veterinary; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*
D014765:Viral Vaccines; D003345:Corticosterone