Comparative activity of 4,4'-diaminobiphenyl (benzidine) and its terphenyl analogue, 4,4'-diaminoterphenyl, in two in vitro assays for potential carcinogenicity.
The carcinogen 4,4'-diaminobiphenyl (benzidine) has been compared in vitro with its terphenyl analogue 4,4''-diaminoterphenyl using the Salmonella reverse mutation assay and the BHK cell-transformation assay. The responses observed, taken together with a consideration of chemical structures, indicate that the terphenyl compound is a potential carcinogen. These findings may contribute to an understanding of the mechanism of action of benzidine as a carcinogen.
Ashby
J
J
Imperial Chemical Industries Limited, Central Toxicology Laboratories, Macclesfield, Cheshire, UK.
Styles
J
J
Callander
R D
RD
D000818:Animals; D001560:Benzidines / Q000633:toxicity*; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D006224:Cricetinae; D009153:Mutagens / Q000633:toxicity*; D012475:Salmonella / Q000187:drug effects / Q000235:genetics; D013730:Terphenyl Compounds / Q000633:toxicity*
D001560:Benzidines; D002273:Carcinogens; D009153:Mutagens; D013730:Terphenyl Compounds; C029876:benzidine; C045996:4,4''-diaminoterphenyl