[Susceptibility of the elderly patient to hyponatremia induced by selective serotonin reuptake inhibitors].
Numerous spontaneous reports of the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) have followed the increased use of selective serotonin reuptake inhibitors (SSRI). It has been estimated that 1 in 200 patients treated per year developed SIADH, age and low body weight being particular risk factors. No clear gender effect has been detected when confounding factors such as body weight or antidepressant consumption are taken into account. Age-related susceptibility to hyponatraemia may be explained by physiological changes in renal and endocrine function. The high prevalence of polymedication and pluripathology in the elderly may be a contributing factor as well. To date, no study has demonstrated how SSRIs affect the regulation of fluid/sodium balance nor whether they have an independent effect on this regulation in depressed subjects.
Fonzo-Christe
C
C
Unité de gérontopharmacologie clinique, Hôpital de Gériatrie, Route de Mon Idée, CH-1226 Thônex, Genève, Suisse.
Vogt
N
N
D000367:Age Factors; D000368:Aged; D000818:Animals; D015897:Comorbidity; D003863:Depression / Q000188:drug therapy; D004198:Disease Susceptibility; D004347:Drug Interactions; D006801:Humans; D007010:Hyponatremia / Q000139:chemically induced* / Q000453:epidemiology; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced* / Q000453:epidemiology; D007668:Kidney / Q000503:physiopathology; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D015995:Prevalence; D051381:Rats; D012306:Risk; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects*; D014667:Vasopressins / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects
D017367:Selective Serotonin Reuptake Inhibitors; D014667:Vasopressins
Susceptibilité du sujet âgé à l'hyponatrémie induite par les inhibiteurs sélectifs du recaptage de la sérotonine.