Synthesis and photodynamic activity of a cationic zinc monoazaporphyrin bearing a nitrogen atom at the peripheral position.
A new cationic monoazaporphyrin, zinc 2-aza-8,12,13,17-tetraethyl-2,3,7,18-tetramethylporphyrinium iodide 3 was synthesized. Photodynamic activity of 3 in degradation of 2',3'-isopropylideneguanosine 4 was compared with 2-aza-8,12,13,17-tetraethyl-3,7,18-trimethylporphyrin 1, zinc 2-aza-8,12,13,17-tetraethyl-3,7,18-trimethylporphyrin 2, and hematoporphyrin 5. The quarternary ammonium 3 showed a remarkable increase of photodynamic activity compared with 5, although no appreciable difference in the activity was observed between 1 and 5.
Kai
S
S
Gifu Pharmaceutical University, Japan. skai@gifu-pu.ac.jp
Hiramitsu
S
S
Suzuki
M
M
Masaki
Y
Y
D001372:Aza Compounds / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002412:Cations; D006151:Guanosine / Q000031:analogs & derivatives / Q000378:metabolism / Q000528:radiation effects; D008665:Metalloporphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D009584:Nitrogen / Q000378:metabolism; D010084:Oxidation-Reduction; D010777:Photochemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014466:Ultraviolet Rays
C427043:2',3'-isopropylideneguanosine; D001372:Aza Compounds; D002412:Cations; D008665:Metalloporphyrins; D017319:Photosensitizing Agents; D006151:Guanosine; C017802:zinc hematoporphyrin; D009584:Nitrogen