title: Comparative study of home and office blood pressure in hypertensive patients treated with enalapril/HCTZ 20/6 mg: the ESPADA study.
abstract: The introduction and generalization of 24-h ambulatory blood pressure (BP) monitoring has shown the clinical relevance of home BP. The aim of this study was to assess the validity of home-measured BP for monitoring and controlling patients with arterial hypertension while on a homogeneous treatment. An additional objective was to establish the degree of office BP control obtained. This was a prospective, longitudinal, observational and multicenter study in a cohort of 156 patients of both sexes, aged over 18 years and with essential hypertension. All of them received the fixed combination enalapril/HCTZ 20/6 mg as the only hypertensive agent for at least 4 weeks previously. Office BP was the average of three measurements. For home BP, a semi-automated device (OMRON HEM 705 CP) was used. The patients measured their BP twice a day for 2 consecutive days. The average differences between the two measuring methods were low, but significant: 3.99 mmHg for systolic BP (SBP; p < 0.05), 2.02 mmHg for diastolic BP (DBP; p < 0.05). Pearson's regression coefficient between the office and home values was highly significant (p < 0.0001) for SBP, DBP and heart rate. Home BP measurement was highly reproducible as shown by the high within-class correlation coefficient for individual measurements on the first day compared with the second: 0.88 (95% confidence interval, CI 0.82-0.92; p < 0.00001) for SBP and 0.89 for DBP (95% CI 0.83-0.93; p < 0.00001). The percentage of patients with strict office DBP and SBP control (< 140/90 mmHg) was 61.3% and with DBP control (<90 mmHg) 92%. In conclusion, in the ESPADA study, the application of home BP measurement is valid, reproducible and shows a high correlation with office BP.
authors.affiliation: Hypertension Unit, 12 de Octubre Hospital, Madrid, Spain. campo@bbvnet.com
authors.forename: C
authors.initials: C
authors.lastname: Campo
authors.forename: G
authors.initials: G
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: González-Esteban
authors.forename: J
authors.initials: J
authors.lastname: Segura
authors.forename: L M
authors.initials: LM
authors.lastname: Ruilope
mesh_terms: D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D001795:Blood Pressure Determination; D018660:Blood Pressure Monitoring, Ambulatory / Q000592:standards*; D002940:Circadian Rhythm; D015331:Cohort Studies; D016001:Confidence Intervals; D004359:Drug Therapy, Combination; D004656:Enalapril / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000494:pharmacology / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009819:Office Visits; D011446:Prospective Studies; D015203:Reproducibility of Results; D012737:Sex Factors
chemical_list: D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D004656:Enalapril