Ketorolac for paediatric postoperative pain. A review.
Ketorolac, a nonsteroidal anti-inflammatory drug (NSAID) largely used in adults, deserves particular attention for postoperative pain therapy in children, even if it is not officially approved for paediatric use. We have examined a lot of studies about the use of ketorolac for paediatric postoperative pain, pointing out pharmacological and pharmacokinetic properties and side effects. There are significant differences in pharmacokinetic parameters, doses, routes of administration, length of treatment, side effects, usage precautions and pharmacological interactions between children and adults. Amongst the many drugs available, ketorolac seems to be particularly efficient for postoperative pain therapy in children too.
Di Massa
A
A
Dipartimento di Scienze Odontostomatologiche, Università degli Studi, Siena.
Scardigli
M
M
Bruni
L
L
Valentino
L
L
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D002648:Child; D004347:Drug Interactions; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D020910:Ketorolac / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy* / Q000517:prevention & control
D000894:Anti-Inflammatory Agents, Non-Steroidal; D020910:Ketorolac