title: Hansen's disease in a patient with a history of sarcoidosis.
abstract: We report a rare case of concomitant Hansen's disease (HD) and sarcoidosis. Reticulin staining may be a helpful diagnostic tool in establishing the diagnosis of sarcoidosis in skin lesions. The diagnosis of HD can be established despite negative polymerase chain reaction results for the detection of Mycobacterium leprae DNA. Finally, a well-established diagnosis of sarcoidosis does not preclude the development of another granulomatous disorder. Hence, when new lesions developed in a patient with sarcoidosis despite appropriate therapy, other concurrent diagnoses should be pursued.
authors.affiliation: Department of Dermatology and Cutaneous Surgery, University of Miami School of Medicine, Jackson Memorial Hospital, P.O. Box 016250 (R-250), Miami, Florida 33101, USA. aburdick@med.miami.edu
authors.forename: A E
authors.initials: AE
authors.lastname: Burdick
authors.forename: A
authors.initials: A
authors.lastname: Hendi
authors.forename: G W
authors.initials: GW
authors.lastname: Elgart
authors.forename: L
authors.initials: L
authors.lastname: Barquin
authors.forename: D M
authors.initials: DM
authors.lastname: Scollard
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D002991:Clofazimine / Q000627:therapeutic use; D003622:Dapsone / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D004576:Electromyography; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007917:Leprostatic Agents / Q000627:therapeutic use; D015441:Leprosy, Tuberculoid / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008199:Lymphadenitis / Q000473:pathology; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000737:chemistry / Q000235:genetics / Q000302:isolation & purification; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D016133:Polymerase Chain Reaction; D011241:Prednisone / Q000627:therapeutic use; D012155:Reticulin / Q000032:analysis; D012293:Rifampin / Q000627:therapeutic use; D012507:Sarcoidosis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D012867:Skin / Q000737:chemistry / Q000473:pathology; D014221:Triamcinolone / Q000627:therapeutic use
chemical_list: D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D007917:Leprostatic Agents; D012155:Reticulin; D014221:Triamcinolone; D006886:Hydroxychloroquine; D003622:Dapsone; D002991:Clofazimine; D007703:Peptidyl-Dipeptidase A; D011241:Prednisone; D012293:Rifampin