title: Biological activity of feijoa peel extracts.
abstract: Fractionated extracts of Feijoa peels were studied for cytotoxic activity, anti-human immunodeficiency virus (HIV) activity and antibacterial activity. Two most cytotoxic fractions A3 of acetone extract and M2 of methanol extract had potent inhibitory activity against Gram-positive and Gram-negative bacteria as well as fungi tested. Fraction A4 of acetone extract showed multidrug resistance (MDR)-reversal activity comparable with that of verapamil (positive control). These results indicate the therapeutic value of Feijoa peel extracts as potential antimicrobial and MDR-modulating agents.
authors.affiliation: Meiji Pharmaceutical University, Kiyose, Tokyo 204-8588, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Motohashi
authors.forename: M
authors.initials: M
authors.lastname: Kawase
authors.forename: Y
authors.initials: Y
authors.lastname: Shirataki
authors.forename: S
authors.initials: S
authors.lastname: Tani
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Sakagami
authors.forename: T
authors.initials: T
authors.lastname: Kurihara
authors.forename: H
authors.initials: H
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Wolfard
authors.forename: I
authors.initials: I
authors.lastname: Mucsi
authors.forename: A
authors.initials: A
authors.lastname: Varga
authors.forename: J
authors.initials: J
authors.lastname: Molnár
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D019380:Anti-HIV Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D009062:Mouth Neoplasms / Q000188:drug therapy; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010945:Plants, Edible / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts