The prognostic significance of autoantibodies against dsDNA in patients with colorectal adenocarcinoma.
BACKGROUND
The tumors of the gastrointestinal system have been associated with various immune disorders. The goal of this study was to correlate the presence of the anti-dsDNA autoantibodies in the serum of patients with colorectal adenocarcinoma suffering from the prognosis of their disease.


METHODS
We investigated 55 patients with colorectal adenocarcinoma, 26 patients with benign surgical disease and 40 healthy volunteers for the presence of anti-dsDNA autoantibodies pre-operatively and one month post-operatively, with an ELISA technique.


RESULTS
The difference of prevalence of anti-dsDNA antibodies between the group of cancer patients and the two control groups was statistically significant (p < 0.001). After a 3-year follow-up, the difference of incidence of the recurrences between the positive and the negative group for anti-dsDNA autoantibodies of the CA patients was statistically significant (P < 0.01).


CONCLUSIONS
The presence of anti-dsDNA autoantibodies in patients with colorectal cancer indicated a better outcome of the course of the disease.
Syrigos
K N
KN
Oncology Unit, 3rd Department of Medicine, Athens Medical School, Sotiria General Hospital, Athens, Greece. knsyrigos@usa.net
Charalambopoulos
A
A
Pliarchopoulou
K
K
Varsamidakis
N
N
Machairas
A
A
Mandrekas
D
D
D000328:Adult; D000368:Aged; D000912:Antibodies, Neoplasm / Q000032:analysis*; D001323:Autoantibodies / Q000032:analysis*; D016022:Case-Control Studies; D003110:Colonic Neoplasms / Q000235:genetics / Q000276:immunology* / Q000601:surgery; D004273:DNA, Neoplasm / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000276:immunology; D011184:Postoperative Period; D011379:Prognosis; D012004:Rectal Neoplasms / Q000235:genetics / Q000276:immunology* / Q000601:surgery
D000912:Antibodies, Neoplasm; D001323:Autoantibodies; D004273:DNA, Neoplasm