[Dynamics of changes in levels of insulin, glucagon, and C-peptide during glucose tolerance test in patients with coronary atherosclerosis].
OBJECTIVE
To study velocity characteristics of changes in the levels of insulin, glucagon and C-peptide in the course of the intravenous glucose tolerance test (IGTT).


METHODS
Glucose, insulin, glucagon and peptide levels were measured in the course of IGTT performed in 50 patients with coronary atherosclerosis (CA) who survived transmural myocardial infarction, 32 individuals with hereditary predisposition to CA and 30 controls free of cardiovascular or endocrine pathology. The results were approximated using high-degree polynomes allowing calculation of the first and second derivatives (the velocity and rate of its change).


RESULTS
CA patients showed inhibited changes of blood glucose, immunoreactive insulin. The reduction of the latter lasted longer than that in the control group.


CONCLUSIONS
Under urgent mobilization of blood glucose regulation system, CA patients develop retention of immunoreactive insulin.
Denisova
T P
TP
Malinov
I A
IA
D002096:C-Peptide / Q000097:blood*; D003324:Coronary Artery Disease / Q000097:blood* / Q000235:genetics; D005934:Glucagon / Q000097:blood*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D009203:Myocardial Infarction / Q000097:blood
D002096:C-Peptide; D007328:Insulin; D005934:Glucagon
Skorostnye kharakteristiki dinamiki urovneĭ insulina, gliukagona i C-peptida v protsesse provedeniia vnutrivennoĭ proby na tolerantnost' k gliukoze pri koronarnom ateroskleroze.