title: [Biosynthesis of Proteus mirabilis nuclease].
abstract: The culture liquid and periplasm of Proteus mirabilis contained nuclease, an enzyme with DNase and RNase activities. The nuclease was most actively synthesized in the early exponential and stationary growth phases. Nuclease synthesis was regulated by nucleic acids (induction by substrate) and inorganic phosphate (end-product inhibition). The synthesis and secretion of nuclease by P. mirabilis was induced by mitomycin C, an inducer of the SOS functions of cells. This suggests the involvement of SOS-response proteins in the regulation of nuclease synthesis.
authors.affiliation: Kazan State University, ul. Lenina 18, Kazan, 420008 Russia.
authors.forename: Z Z
authors.initials: ZZ
authors.lastname: Salikhova
authors.forename: R B
authors.initials: RB
authors.lastname: Sokolova
authors.forename: D V
authors.initials: DV
authors.lastname: Iusupova
mesh_terms: D003470:Culture Media; D003851:Deoxyribonucleases / Q000096:biosynthesis*; D011513:Proteus mirabilis / Q000201:enzymology*; D012260:Ribonucleases / Q000096:biosynthesis*; D013014:SOS Response, Genetics
chemical_list: D003470:Culture Media; D003851:Deoxyribonucleases; D012260:Ribonucleases
vernacular_title: Biosintez nukleazy Proteus mirabilis.