8-Amido-Bearing pseudomycin B (PSB) analogue: novel antifungal agents.
During the course of a structure-activity relationship (SAR) study on novel depsinonapeptide pseudomycin B, we synthesized a total of 12 8-amidopseudomycin analogues via standard two-step sequence from either ZPSB 2 or AllocPSB 3. A number of these amides exhibited good in vitro antifungal activities.
Zhang
Y Z
YZ
Lilly Research Laboratories, A Division of Eli Lilly and Company, Lillly Corporate Center, Indianapolis, IN 46285, USA.
Sun
X
X
Zeckner
D J
DJ
Sachs
R K
RK
Current
W L
WL
Chen
S H
SH
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D020650:Combinatorial Chemistry Techniques; D003455:Cryptococcus neoformans / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D051379:Mice; D008826:Microbial Sensitivity Tests; D023421:Models, Animal; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D010456:Peptides, Cyclic; C425223:pseudomycin B