Resolution of positional isomers by capillary electrochromatography.
Electroseparations have been very successful in increasing efficiencies and reducing analysis times. The analytical technique originally applied to open tube capillaries (capillary electrophoresis) has been used as a basis to develop renewed interest in electrochromatography. This paper describes the use of capillary electrochromatography to separate two positional isomers and describes a comparison between gas chromatography (GC), capillary electrochromatography (CEC) and nano-HPLC. The resolution of these isomers is quite crucial, since one of the isomers is the impurity in a pharmaceutically active drug.
Hindocha
D
D
Development Chemistry 5, Chemical Development Division, GlaxoWellcome Medicines Research Centre, Stevenage, Herts, UK.
Smith
N W
NW
D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods*; D007536:Isomerism