Subconjunctival cephalosporin anaphylaxis.
This case describes a patient who developed a systemic anaphylactic reaction to a subconjunctival injection of cephalosporin. The patient did well, but required intensive therapy, including airway intubation. She had a history of penicillin allergy. Even 50 mg of cephalosporin antibiotic injected locally can produce a life threatening anaphylactic reaction.
Berrocal
A M
AM
New England Eye Center, Boston, Massachusetts, USA.
Schuman
J S
JS
D000368:Aged; D000707:Anaphylaxis / Q000209:etiology*; D002437:Cefazolin / Q000008:administration & dosage / Q000009:adverse effects*; D002511:Cephalosporins / Q000008:administration & dosage / Q000009:adverse effects*; D003228:Conjunctiva / Q000187:drug effects*; D005260:Female; D006801:Humans; D007267:Injections; D012128:Respiratory Distress Syndrome / Q000139:chemically induced*; D014581:Urticaria / Q000139:chemically induced*
D002511:Cephalosporins; D002437:Cefazolin