Expression of p53 and lactate dehydrogenase in murine fibrosarcoma following exposure to gamma-radiation.
Radiation-induced alterations in the levels of p53 and lactate dehydrogenase activities were studied in fibrosarcoma, following exposure to different doses of gamma-irradiation (2-10 Gy). The levels of p53 were elevated in the cytoplasm, while the lactate dehydrogenase activity in tumor tissue was considerably decreased.
Wani
K
K
Radiation Oncology Division, Nanavathi Hospital and Medical Research Centre, Mumbai, India.
Rajagopalan
R
R
Huilgol
N G
NG
Nair
C K
CK
D000818:Animals; D005354:Fibrosarcoma / Q000378:metabolism*; D005720:Gamma Rays; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D051379:Mice; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*; D014916:Whole-Body Irradiation
D016159:Tumor Suppressor Protein p53; D007770:L-Lactate Dehydrogenase