Interaction of Strychnos nux-vomica-products and iron: with reference to lipid peroxidation.
In this paper, it has been investigated that strychnine, the major active principle in the alcoholic extract of the seeds of Strychnos nux-vomica, is responsible for its antilipid peroxidative property. The mechanism of action of this drug is through the chelation of the free iron in the system. It has also been observed that strychnine does not have any pro-oxidant-property, because it does not convert Fe3+ to Fe2+ and vice versa in the reaction system, as has been observed with several other antioxidants.
Tripathi
Y B
YB
Department of Medicinal Chemistry, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India. yamini@banaras.ernet.in
Chaurasia
S
S
D000975:Antioxidants / Q000737:chemistry*; D006801:Humans; D007501:Iron / Q000737:chemistry*; D007502:Iron Chelating Agents / Q000737:chemistry; D015227:Lipid Peroxidation; D010084:Oxidation-Reduction; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013331:Strychnine / Q000737:chemistry*
D000975:Antioxidants; D007502:Iron Chelating Agents; D010936:Plant Extracts; D007501:Iron; D013331:Strychnine