BsmI vitamin D receptor polymorphism and pathogenesis of parathyroid adenoma.
BACKGROUND
The role of vitamin D receptor (VDR) gene polymorphism in the pathogenesis of hyperparathyrodism is not clear yet. The aim of this study was to examine the role of BsmI VDR gene polymorphism in patients with primary hyperparathyrodism (PHP) secondary to adenomas.


METHODS
Fifty-two postmenopausal women with PHP, mean age 64.5 years, were compared with a normal age-matched female population (n = 81).


RESULTS
Distribution of BsmI polymorphism in PHP group was: Bb 54% (28/52); BB 21% (11/52); bb 25% (13/52). In the control group, the distribution in PHP group as follows: Bb 49% (40/81); BB 16% (13/81); bb 35% (28/81). No statistical differences were found between the two groups. In the PHP group, no statistical associations were found between different allelic distribution and age, creatinine, hematocrit, phosphorus, alkaline phosphatase (ALP), total calcium, serum parathyroid hormone (PTH), or gland weight. This data suggest that at least in this group, BsmI VDR gene polymorphism appears to be without relevance in clinical presentation and possibly tumorigenesis in PHP secondary to adenomas.
Pacheco
D
D
Department of Surgery, Hospital General Universitario Gregorio Marañón, Madrid, Spain.
Menárguez
J
J
Cristobal
E
E
Arribas
B
B
Alcazar
J A
JA
Carrión
R
R
Polo
J R
JR
D000236:Adenoma / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D000368:Aged; D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific; D005260:Female; D005838:Genotype; D006801:Humans; D006961:Hyperparathyroidism / Q000209:etiology / Q000235:genetics / Q000378:metabolism; D008875:Middle Aged; D010282:Parathyroid Neoplasms / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D012150:Polymorphism, Restriction Fragment Length; D018167:Receptors, Calcitriol / Q000235:genetics*
D018167:Receptors, Calcitriol; C053864:endodeoxyribonuclease BsmI; D015252:Deoxyribonucleases, Type II Site-Specific