Curative property of Withania somnifera Dunal root in the context of carbendazim-induced histopathological changes in the liver and kidney of rat.
The liver and kidney of rat underwent severe histopathological lesions when treated with a single bolus dose of carbendazim, a fungicide, particularly affecting the hepatocytes and the renal corpuscles, respectively. The effects appear to be manifestations of the microtubule-disrupting activity of carbendazim. Treatment of carbendazim-treated rats with the powder of tuberous root of Withania somnifera (Ashwagandha) for 48 days resulted in complete cure of these organs. The results indicate that Withania somnifera would be an effective curative for carbendazim-induced histopathological changes in the liver and kidney.
Akbarsha
M A
MA
Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, India. Akbar@bdu.ernet.in
Vijendrakumar
S
S
Kadalmani
B
B
Girija
R
R
Faridha
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D001562:Benzimidazoles; D002219:Carbamates; D056486:Chemical and Drug Induced Liver Injury; D005659:Fungicides, Industrial; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008515:Medicine, Ayurvedic; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D018517:Plant Roots; D051381:Rats; D017208:Rats, Wistar; D032341:Withania
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001562:Benzimidazoles; D002219:Carbamates; D005659:Fungicides, Industrial; D010936:Plant Extracts; C006698:carbendazim; C030693:Ashwagandha