title: Paraneoplastic anti-CV2 antibodies react with peripheral nerve and are associated with a mixed axonal and demyelinating peripheral neuropathy.
abstract: Subacute sensory neuronopathy with anti-Hu antibodies is the best-characterized paraneoplastic peripheral neuropathy associated with carcinoma. Anti-CV2 antibodies, another group of paraneoplastic antibodies, react with a 66-kd brain protein belonging to the family of Ulip/CRMP proteins. The manifestations associated with anti-CV2 antibodies include cerebellar degeneration, uveitis, and peripheral neuropathy. Some of these patients also have anti-Hu antibodies. We have compared the clinical, electrophysiological, and pathological characteristics of the peripheral neuropathy in 9 patients with anti-CV2 antibodies (3 of whom also had anti-Hu antibodies) and 12 patients with only anti-Hu antibodies. Data for patients with anti-Hu antibodies alone indicated subacute sensory neuronopathy. Patients with anti-CV2 antibodies had a mixed axonal and demyelinating sensory motor neuropathy that was sometimes superimposed on subacute sensory neuronopathy when both anti-CV2 and anti-Hu antibodies were present. Unlike anti-Hu antibodies, anti-CV2 antibodies reacted with peripheral nerve antigens, as shown by their ability to bind to a 66-kd protein in human and rat nerve on Western blot analysis and to immunolabel peripheral nerve axons and sensory neurons on immunohistochemical study.
authors.affiliation: Equipe d'Accueil 3063, Faculté de Médecine de Saint-Etienne, Service de Neurologie, H pital de Bellevue, France. 113464.3717@compuserve.com
authors.forename: J C
authors.initials: JC
authors.lastname: Antoine
authors.forename: J
authors.initials: J
authors.lastname: Honnorat
authors.forename: J P
authors.initials: JP
authors.lastname: Camdessanché
authors.forename: M
authors.initials: M
authors.lastname: Magistris
authors.forename: L
authors.initials: L
authors.lastname: Absi
authors.forename: J F
authors.initials: JF
authors.lastname: Mosnier
authors.forename: P
authors.initials: P
authors.lastname: Petiot
authors.forename: N
authors.initials: N
authors.lastname: Kopp
authors.forename: D
authors.initials: D
authors.lastname: Michel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001369:Axons / Q000276:immunology*; D003711:Demyelinating Diseases / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D020364:Paraneoplastic Polyneuropathy / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D010525:Peripheral Nerves / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic