title: Inadvertent diclofenac rechallenge from generic and non-generic prescribing, leading to liver transplantation for fulminant liver failure.
abstract: This case report describes fulminant hepatic failure in a 53-year-old female caused by inadvertent rechallenging with diclofenac, treated by orthotopic liver transplantation. The case also illustrates the hazards of using both generic and non-generic drug prescribing, with drugs that are known to be toxic. The literature on non-steroidal anti-inflammatory drugs and hepatoxicity is reviewed.
authors.affiliation: Department of Liver Transplantation and Hepatobiliary Medicine, Royal Free Hospital, London, UK.
authors.forename: R R
authors.initials: RR
authors.lastname: Greaves
authors.forename: A
authors.initials: A
authors.lastname: Agarwal
authors.forename: D
authors.initials: D
authors.lastname: Patch
authors.forename: S E
authors.initials: SE
authors.lastname: Davies
authors.forename: D
authors.initials: D
authors.lastname: Sherman
authors.forename: N
authors.initials: N
authors.lastname: Reynolds
authors.forename: K
authors.initials: K
authors.lastname: Rolles
authors.forename: B R
authors.initials: BR
authors.lastname: Davidson
authors.forename: A K
authors.initials: AK
authors.lastname: Burroughs
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004008:Diclofenac / Q000009:adverse effects*; D016568:Drugs, Generic; D005260:Female; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced* / Q000601:surgery*; D016031:Liver Transplantation; D008875:Middle Aged
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016568:Drugs, Generic; D004008:Diclofenac