p53 and p21 are major cellular determinants for DNA topoisomerase I-mediated radiation sensitization in mammalian cells.
Chen
A Y
AY
Department of Radiation Oncology, Vanderbilt University Medical Center, 1301 22nd Ave. S., Vanderbilt Clinic, Nashville, TN 37232-5671, USA. Allan.chen@mcmail.vanderbilt.edu
Scruggs
P B
PB
Geng
L
L
Rothenberg
M L
ML
Hallahan
D E
DE
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D016466:CHO Cells / Q000187:drug effects / Q000528:radiation effects; D002166:Camptothecin / Q000494:pharmacology; D006224:Cricetinae; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000502:physiology*; D004264:DNA Topoisomerases, Type I / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D011836:Radiation Tolerance / Q000187:drug effects / Q000502:physiology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
D000972:Antineoplastic Agents, Phytogenic; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D004791:Enzyme Inhibitors; D011838:Radiation-Sensitizing Agents; D059004:Topoisomerase I Inhibitors; D016159:Tumor Suppressor Protein p53; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin