Optimizing the science of drug development: opportunities for better candidate selection and accelerated evaluation in humans.
Lesko
L J
LJ
Office of Clinical Pharmacology and Biopharmaceutics, Center for Drug Evaluation and Research, Food and Drug Administration, Rockville, Maryland 20851, USA.
Rowland
M
M
Peck
C C
CC
Blaschke
T F
TF
D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods*; D015195:Drug Design; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D010599:Pharmacokinetics; D010601:Pharmacology, Clinical / Q000379:methods*