title: [Morpho-functional changes of surfactant system in pulmonary tuberculosis].
abstract: A complex study of different cellular and extracellular surfactant elements in the dynamics of the spontaneous course of generalized tuberculosis was made in 240 guinea-pigs and 77 patients with different forms of active pulmonary tuberculosis by using electron microscopy, biochemistry, and physical chemistry. A diagnostic scheme was proposed for life-time assessment of surfactant in bronchoalveolar lavage specimens. Three degrees of changes in surfactant were identified; 1) adaptive rearrangement of its elements developing in local surfactant damages; 2) significantly impaired type 2 alveolocyte production of surfactant, which affects its biochemical composition and capacity of forming characteristic structures; 3) common morphological, biochemical, surface-active signs of surfactant decompensation, profound metabolic disturbances, alveolar epithelial destruction with cleared alveolocytes found in the lavage.
authors.forename: V V
authors.initials: VV
authors.lastname: Erokhin
authors.forename: L N
authors.initials: LN
authors.lastname: Lepekha
mesh_terms: D000818:Animals; D015415:Biomarkers; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D018450:Disease Progression; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D006168:Guinea Pigs; D006801:Humans; D011650:Pulmonary Alveoli / Q000378:metabolism / Q000648:ultrastructure*; D011663:Pulmonary Surfactants / Q000378:metabolism* / Q000648:ultrastructure; D014397:Tuberculosis, Pulmonary / Q000378:metabolism* / Q000473:pathology
chemical_list: D015415:Biomarkers; D011663:Pulmonary Surfactants
vernacular_title: Morfofunktsional'nye izmeneniia surfaktantnoĭ sistemy pri tuberkuleze legkikh.