Seizure outcomes after anterior callosotomy in patients with posterior-dominant and with anterior-dominant epileptiform discharges.
OBJECTIVE
We wished to find whether there was any difference in the postoperative seizure outcome between patients with bisynchronous anterior-dominant and those with posterior-dominant EDs after anterior callosotomy.


METHODS
Seizure outcomes after anterior callosotomy in 7 patients with bisynchronous posterior-dominant epileptiform discharges and in 54 patients with anterior-dominant seizures were compared. All 61 cases had been followed up for more than 2 years after operation. One patient (14.3%) had become seizure free. Two patients (28.6%) had more than 50% reduction in seizure frequency, but 4 patients (57.2%) showed no improvement at all. The percentage of cases with significant improvement (more than 50% reduction of seizure frequency) was 43% (3 in 7), which is lower than in the patients with bisynchronous anterior-dominant EDs (64.8%).


CONCLUSIONS
Our preliminary results suggest that anterior partial callosotomy could still be helpful in cases with bisynchronous posterior-dominant epileptiform discharges but the prognosis may be less optimistic than for those with anteriorly located discharges.
Kwan
S Y
SY
Section of Epilepsy, Neurological Institute, Taipei Veterans General Hospital, Taiwan, ROC. sykwan@vghtpe.gov.tw
Wong
T T
TT
Chang
K P
KP
Yang
T F
TF
Lee
Y C
YC
Guo
W Y
WY
Su
M S
MS
D002648:Child; D002675:Child, Preschool; D003337:Corpus Callosum / Q000503:physiopathology* / Q000601:surgery*; D004827:Epilepsy / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012720:Severity of Illness Index; D016896:Treatment Outcome