[Sensory neurons and Schwann cells during pharmacologic stimulation of the nerve regeneration].
Using the model of rat sciatic nerve transection and crush injury we studied influence of pyrimidine derivative xymedon on efficacy of regeneration of myelinated axons, number and phenotype of surviving sensory neurons (expressing GAP-43 and Bcl-2) and Schwann cells (S100, GAP-43, PCNA) on the 7th, 15th, 30th, 60th and 90th day after nerve injury. We found out that xymedon counteracts posttraumatic death of sensory neurons, stimulates regeneration of myelinated fibres and proliferation of Schwann cells.
Raginov
I S
IS
Department of Histology, Cytology and Embryology, Medical University, Kazan.
Chelyshev
Iu A
IuA
D000818:Animals; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000187:drug effects*; D009475:Neurons, Afferent / Q000166:cytology*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D012583:Schwann Cells / Q000166:cytology* / Q000648:ultrastructure; D012584:Sciatic Nerve / Q000166:cytology / Q000502:physiology* / Q000648:ultrastructure
D011743:Pyrimidines; C069705:xymedon
Chuvstvitel'nye neĭrony i Shvanovskie kletki pri farmakologicheskoĭ stimuliatsii regeneratsii nerva.