Recombinant human lactoferrin is effective in the treatment of Helicobacter felis-infected mice.
Recombinant human lactoferrin possesses in-vitro antibiotic and anti-inflammatory activity similar to the native form. It was tested for in-vivo activity in mice infected with the gastritis-inducing bacterium Helicobacter felis. A two-week course of treatment with lactoferrin was sufficient to partially reverse both infection-induced gastritis and the infection rate, and fully reverse gastric surface hydrophobicity changes. A comparison of lactoferrin with amoxicillin and standard triple therapy revealed no differences in infection rate. These results show that recombinant human lactoferrin is effective in a mouse model of Helicobacter infection, and support further testing of this promising agent for this application.
Dial
E J
EJ
The University of Texas Health Science Center, Houston Medical School, Department of Integrative Biology and Pharmacology, 77225, USA. edial@girch1.med.uth.tmc.edu
Romero
J J
JJ
Headon
D R
DR
Lichtenberger
L M
LM
D000658:Amoxicillin / Q000494:pharmacology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005756:Gastritis / Q000188:drug therapy* / Q000209:etiology; D016998:Helicobacter / Q000187:drug effects*; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D007781:Lactoferrin / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D010406:Penicillins / Q000494:pharmacology; D011994:Recombinant Proteins / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects / Q000473:pathology; D013997:Time Factors
D010406:Penicillins; D011994:Recombinant Proteins; D000658:Amoxicillin; D007781:Lactoferrin