title: Equine herpesvirus 9 induced lethal encephalomyelitis in experimentally infected goats.
abstract: The pathogenicity of a new neurotropic equine herpesvirus 9 (EHV-9) formerly designated gazelle herpesvirus 1 was evaluated using the goat as a representative of domesticated ruminants. Two goats inoculated intranasally with EHV-9 showed salivation, teeth grinding and other neurological disorders on day 8 post inoculation. One goat died 30 min after the onset of clinical signs and the other was sacrificed 3 h after the sudden onset of teeth grinding and foamy salivation. EHV-9 was recovered from peripheral white blood cells, the olfactory bulbs and brain, nasal swabs, concha, and lungs. Neuropathological lesions were located in the olfactory bulbs, cerebrum, midbrain and medulla oblongata with degeneration and necrosis of neurons, rarefaction, perivascular infiltration of mononuclear cells, and nodal glial reaction. EHV-9 antigen was detected in neurons in the lesions. These findings indicated that EHV-9 is highly pathogenic with high neurotropism for goats.
authors.affiliation: Department of Veterinary Pathology, Gifu University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Taniguchi
authors.forename: H
authors.initials: H
authors.lastname: Fukushi
authors.forename: T
authors.initials: T
authors.lastname: Yanai
authors.forename: T
authors.initials: T
authors.lastname: Masegi
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: K
authors.initials: K
authors.lastname: Hirai
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000473:pathology / Q000821:virology*; D018792:Encephalitis, Viral / Q000662:veterinary*; D005260:Female; D015511:Goat Diseases / Q000473:pathology / Q000821:virology*; D006041:Goats; D006566:Herpesviridae Infections / Q000662:veterinary*; D007962:Leukocytes / Q000821:virology; D008168:Lung / Q000821:virology; D008297:Male; D008526:Medulla Oblongata / Q000473:pathology; D008636:Mesencephalon / Q000473:pathology; D009297:Nasal Mucosa / Q000821:virology; D009336:Necrosis; D009474:Neurons / Q000821:virology; D009830:Olfactory Bulb / Q000473:pathology / Q000821:virology; D012472:Salivation; D013045:Species Specificity; D013687:Telencephalon / Q000473:pathology; D014420:Turbinates / Q000821:virology; D018140:Varicellovirus / Q000472:pathogenicity
chemical_list: D000956:Antigens, Viral