Automation of the synthesis of highly concentrated 188Re-MAG3 for intracoronary radiation therapy.
We have developed an efficient method and an automated synthetic system for the preparation of highly concentrated 188Re-MAG3. Routine production of 188Re-MAG3 for use in intracoronary radiation therapy was performed by compressed air driven semi-automated shielded system. 188Re-MAG3 was prepared with a commercial kit and reducing agents, purified and concentrated by C18 Sep-Pak cartridges to desired radioactivity and volume. Using this automated system, reproducible radiolabeling yields of 80-85% were obtained.
Oh
S J
SJ
Department of Nuclear Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea. sjoh@www.amc.seoul.kr
Moon
D H
DH
Ha
H J
HJ
Park
S W
SW
Hong
M K
MK
Park
S J
SJ
Choi
T H
TH
Lim
S M
SM
Choi
C W
CW
Knapp
F F
FF
Lee
H K
HK
D015906:Angioplasty, Balloon, Coronary; D001331:Automation; D003327:Coronary Disease / Q000532:radiotherapy* / Q000628:therapy; D006801:Humans; D008722:Methods; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000627:therapeutic use*; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000627:therapeutic use*; D011868:Radioisotopes / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000627:therapeutic use*; D012211:Rhenium / Q000627:therapeutic use*
D009842:Oligopeptides; D009942:Organometallic Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C114893:rhenium-mercaptoacetyltriglycine; D012211:Rhenium