Recurrence and accelerated progression of hepatitis C following liver transplantation.
The patient described had recurrent hepatitis C following OLT. This hepatitis appeared early postOLT and progressed to fibrosing cholestatic hepatitis, a severe form of HCV recurrence. Factors such as genotype 1, high viral load and severe damage on the first postOLT biopsy may indicate a more severe outcome. We have hypothesized that, in parallel to what is known for hepatitis B, this rare form of recurrence was linked to a high expression of virus C proteins in the liver graft. Severe form of hepatitis C recurrence should be treated early with the best currently available treatment which is a combination of IFN and ribavirin. Large series of patients with comparable virological, histological and immunological inclusions criteria are necessary to evaluate the efficacy of this treatment.
Bernard
P H
PH
Service d'Anatomie Pathologique, laboratoire de Virologie, et Service de Chirurgie Digestive et de Transplantation Hépatique, Hôpitaux Pellegrin et St André, C.H.U. Bordeaux, France.
Le Bail
B
B
Rullier
A
A
Trimoulet
P
P
Neau-Cransac
M
M
Balabaud
C
C
Bioulac-Sage
P
P
D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis; D001663:Bilirubin / Q000097:blood; D004279:DNA, Viral / Q000032:analysis; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006084:Graft Rejection; D006526:Hepatitis C / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D007150:Immunohistochemistry; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D016031:Liver Transplantation; D012008:Recurrence; D000637:Transaminases / Q000097:blood; D019562:Viral Load
D000914:Antibodies, Viral; D004279:DNA, Viral; D007166:Immunosuppressive Agents; D000637:Transaminases; D001663:Bilirubin