title: Osteoblastoma-like osteosarcoma.
abstract: We report an osteoblastoma-like osteosarcoma in the right proximal fibula in a 22-year-old woman. Radiographs showed an irregular osteolytic lesion from the metaphysis to the epiphysis in the proximal fibula with partial destruction of cortical bone. Tissue from a biopsy indicated a typical osteoblastoma. Curettage and bone graft was performed. One year after the surgery, local recurrence occurred, and a wide excision was performed. Histological examination of the en-bloc surgical specimen revealed the tumor had permeated through the host bony trabeculae, although the nuclear atypia was not marked. Immunohistochemical expression of MIB-1 was detected in 9.0% of cells.
authors.affiliation: Department of Orthopaedics, Akita University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tani
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Shoji
authors.forename: M
authors.initials: M
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Sageshima
mesh_terms: D000328:Adult; D034961:Antigens, Nuclear; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D005360:Fibula / Q000473:pathology* / Q000601:surgery; D006801:Humans; D019394:Ki-67 Antigen; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D009687:Nuclear Proteins / Q000032:analysis; D018215:Osteoblastoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012516:Osteosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D034961:Antigens, Nuclear; D019394:Ki-67 Antigen; D009687:Nuclear Proteins