Spray-dried microspheres containing ketoprofen formulated into capsules and tablets.
In this study, microspheres were prepared by a spray-drying technique using solutions of ketoprofen and two polymers, cellulose acetate butyrate (CAB) and hydroypropylmethylcellulose phthalate (HPMCP), in different weight ratios. Different total concentrations were used in the feed solutions: 3, 6 and 9% w/v. The spray-dried microparticles were characterized in terms of shape (SEM), size (light scattering method), production yield and encapsulation efficiency. They were formulated into capsules; tablets were prepared by direct compression of the microparticles mixed with maltose and, in some cases, hydroypropylmethylcellulose (HPMC). In vitro release studies were performed both at acidic and neutral pHs. The spray-drying process of solutions of ketoprofen with polymeric blends of cellulose derivatives leads to microparticles which, depending on their final formulation (capsules or tablets), can give a rapid or prolonged drug release. The formulations here described can be proposed for the oral administration of NSAIDs.
Moretti
M D
MD
Dipartimento di Scienze del Farmaco, Università di Sassari, Italy.
Gavini
E
E
Juliano
C
C
Pirisino
G
G
Giunchedi
P
P
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000737:chemistry; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives*; D007660:Ketoprofen / Q000008:administration & dosage* / Q000737:chemistry; D008027:Light; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D008970:Molecular Weight; D010316:Particle Size; D012542:Scattering, Radiation; D013607:Tablets
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D013607:Tablets; D002482:Cellulose; C014396:cellulose acetate-butyrate; D007660:Ketoprofen