title: Ventricular preexcitation in children and young adults: atrial myocarditis as a possible trigger of sudden death.
abstract: BACKGROUND
  Sudden death (SD) in ventricular preexcitation (VP) syndrome is believed to be the result of atrial fibrillation with rapid ventricular response over the accessory pathway. Previous reports are anecdotal and often lack autopsy validation.
  
  
  RESULTS
  Prevalence and clinicopathological features of VP were investigated in a series of 273 SDs in children and young adults (aged <or=35 years). Site of accessory atrioventricular (AV) connection was predicted by 12-lead ECG. Right and left AV ring together with the sinoatrial and AV septal junction were studied in serial histological sections. Ten patients (3.6%; male, mean age 24+/-7 years) had VP: 8 had Wolff-Parkinson-White (WPW) and 2 had Lown-Ganong-Levine (LGL) syndrome. Six patients had previous symptoms, and SD occurred at rest in all but 1. Pathological substrates of LGL consisted of AV-node hypoplasia and right-sided atrio-Hisian tract, respectively. In the 8 WPW patients, 10 total accessory AV pathways consisting of ordinary myocardium were found (7 left lateral, 2 right posterolateral, and 1 septal). These pathways were close to the endocardium (mean distance, 750+/-530 microm) and 310+/-190 microm thick. In 4 WPW patients (50%), isolated acute atrial myocarditis was found, which was polymorphous in 1 and lymphocytic in 3.
  
  
  CONCLUSIONS
  VP accounted for 3.6% of SD in young people and was not preceded by warning symptoms in 40%. A left accessory pathway was the most frequent substrate, and its subendocardial location supports the feasibility of catheter ablation. Isolated atrial myocarditis may act as a trigger of paroxysmal atrial fibrillation that leads to SD.
authors.affiliation: Department of Pathology, University of Padua Medical School, Padua, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Basso
authors.forename: D
authors.initials: D
authors.lastname: Corrado
authors.forename: L
authors.initials: L
authors.lastname: Rossi
authors.forename: G
authors.initials: G
authors.lastname: Thiene
mesh_terms: D000328:Adult; D001283:Atrioventricular Node / Q000473:pathology; D002036:Bundle of His / Q000473:pathology; D002648:Child; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D004562:Electrocardiography; D005260:Female; D006325:Heart Atria; D006801:Humans; D008151:Lown-Ganong-Levine Syndrome / Q000150:complications / Q000473:pathology; D008297:Male; D009205:Myocarditis / Q000150:complications*; D009206:Myocardium / Q000473:pathology; D011226:Pre-Excitation Syndromes / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D011446:Prospective Studies; D012849:Sinoatrial Node / Q000473:pathology; D014927:Wolff-Parkinson-White Syndrome / Q000150:complications / Q000473:pathology