Effects of two saponins extracted from the polygonatum Zanlanscianense pamp on the human leukemia (HL-60) cells.
Two saponins, methyl protodioscin and dioscin, were extracted from the root of Polygonatum Zanlanscianense Pamp. One of them, dioscin exerted significant inhibitory effects on the growth of the human leukemia cell HL-60, inducing differentiation and apoptosis. HL60 cells were induced mainly along the granulocytic lineage. In addition, we have found that dioscin affects many cancer cells. These studies may have important significance in treating related cancers.
Wang
Z
Z
Department of Biological Science and Biotechnology, Tsinghua University, Beijing, China. zwang@tsinghua.edu.cn
Zhou
J
J
Ju
Y
Y
Zhang
H
H
Liu
M
M
Li
X
X
D017209:Apoptosis / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004144:Diosgenin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D012503:Saponins; C425324:methyl protodioscin; C019357:dioscin; D004144:Diosgenin