[MRI-assisted brachytherapy of nonresectable liver metastases. Preliminary technical and clinical experiences].
OBJECTIVE
To evaluate the feasibility and efficacy of MR-guided interstitial brachytherapy of non-resectable liver metastasis.


METHODS
Liver metastases (0.8-5.2 cm in diameter) were treated during a prospective phase I/II study using an open 0.2 Tesla MR system (Magnetom Open Viva, Siemens, Erlangen). MR-compatible brachytherapy applicators were placed percutaneously under MR-guidance in an open 0.2 Tesla MR system (Magnetom Open Viva, Siemens, Erlangen) using fast T1-weighted sequences. Pretreatment and follow-up studies were performed using a 1.5 Tesla MR system.


RESULTS
Preliminary results of an unpublished prospective study are discussed exemplary on 2 selected patients. The median procedure time was 4.9 h. No major complications were observed and late effects were acceptable. In large symptomatic metastases only a temporary relief of pain was achieved. In smaller metastases (DM 3 cm) a tumor control was observed.


CONCLUSIONS
MR-guided brachytherapy is feasible and has the potential to ablate liver metastases with diameter of less than 3 cm. Further developments are necessary.
Kettenbach
J
J
Abteilung für Angiographie und Interventionelle Radiologie, Univ.-Klinik für Radiodiagnostik, Universitätsklinik Wien, Allgemeines Krankenhaus der Stadt Wien, Währinger Gürtel 18-20, 1090 Wien/Osterreich. joachim.kettenbach@univie.ac.at
Pokrajac
B
B
Schamp
S
S
Fellner
C
C
Schmid
R
R
Gustorff
B
B
Berger
J
J
Grgurin
M
M
Peer
K
K
Wolff
U
U
Seitz
W
W
Pötter
R
R
Lammer
J
J
D000230:Adenocarcinoma / Q000175:diagnosis / Q000532:radiotherapy / Q000556:secondary*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000295:instrumentation*; D015179:Colorectal Neoplasms / Q000175:diagnosis / Q000532:radiotherapy*; D004867:Equipment Design; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007089:Image Enhancement; D008113:Liver Neoplasms / Q000175:diagnosis / Q000532:radiotherapy / Q000556:secondary*; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D016896:Treatment Outcome
MR-gestützte Brachytherapie nichtresektabler Lebermetastasen. Vorläufige technische und klinische Erfahrungen.