Lipid peroxidation in nicotinamide-deficient and nicotinamide-supplemented rats.
Supplementation or deficiency of nicotinamide in rats may interfere with the oxidative balance, with excess leading to greater lipid peroxidation, measured by TBARS, and deficiency causing a greater consumption of antioxidants such as vitamin E and glutathione. Urinary N-methylnicotinamide excretion was much more marked in the supplemented group, whereas the difference between deficient and control animals was nonsignificant.
Melo
S S
SS
Dept. of Internal Medicine, Nutrition Division, Faculty of Medicine of Ribeirão Preto, São Paulo University, Av. Bandeirantes 3900, 14049-900 Ribeirão Preto/SP, Brazil.
Meirelles
M S
MS
Jordão Júnior
A A
AA
Vannucchi
H
H
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D019587:Dietary Supplements; D005978:Glutathione / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009243:NAD; D009536:Niacinamide / Q000031:analogs & derivatives / Q000172:deficiency* / Q000378:metabolism / Q000494:pharmacology* / Q000652:urine; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E / Q000378:metabolism
D000975:Antioxidants; D017392:Thiobarbituric Acid Reactive Substances; D009243:NAD; D014810:Vitamin E; D009536:Niacinamide; D005978:Glutathione; C008472:N-methylnicotinamide