A chemokine, SDF-1/PBSF, and its receptor, CXC chemokine receptor 4, as mediators of hematopoiesis.
A chemokine, stromal cell-derived factor/pre-B-cell growth-stimulating factor (SDF-1/PBSF), and its primary physiologic receptor, CXC chemokine receptor 4 (CXCR4), are essential for B-lymphocyte production and colonization of bone marrow by myeloid lineage progenitors during embryogenesis. Moreover, CXCR4 is an autonomous cell essential for long-term lymphoid and myeloid reconstitution in adult bone marrow. Upregulation of CXCR4 expression may be useful for improving engraftment of repopulating stem cells in clinical transplantation.
Nagasawa
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Department of Immunology, Research Institute, Osaka Medical Center for Maternal and Child Health, Izumi, Osaka, Japan.
D000818:Animals; D001853:Bone Marrow / Q000502:physiology; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000502:physiology*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D051379:Mice; D019718:Receptors, CXCR4 / Q000502:physiology*
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; C515256:Cxcl12 protein, mouse; D019718:Receptors, CXCR4