title: [Anti-inflammatory effect of fensulkal].
abstract: Experiments on various animals showed that fensulkal, a new phenylglyoxylic acid derivative, possesses a high antiinflammatory activity and low toxicity, markedly exceeding butadion in the therapeutic index. The mechanism of the antiphlogistic effect of fensulkal is due to its antagonism with respect to mediators of the inflammatory process and the ability of suppressing the increased permeability of capillaries and is partly related to the adrenal cortex. The drug is registered and recommended for application as antiinflammatory remedy in the form of ointment to be used for the treatment of some gynecological disorders.
authors.affiliation: Sultanov Research Institute of Pharmaceutical Chemistry, ul. F. Khodzhaeva 40, Tashkent, 700187 Uzbekistan.
authors.forename: A U
authors.initials: AU
authors.lastname: Zakirov
authors.forename: D N
authors.initials: DN
authors.lastname: Karshiev
authors.forename: U M
authors.initials: UM
authors.lastname: Azizov
authors.forename: L I
authors.initials: LI
authors.lastname: Leont'eva
mesh_terms: D000085:Acetates / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy; D002056:Burns / Q000188:drug therapy; D002415:Cats; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D007928:Lethal Dose 50; D051379:Mice; D010147:Pain Measurement; D010538:Peritonitis / Q000188:drug therapy; D010653:Phenylbutazone / Q000627:therapeutic use / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D013451:Sulfonic Acids / Q000627:therapeutic use*; D023382:Toxicity Tests, Acute
chemical_list: D000085:Acetates; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013451:Sulfonic Acids; C423308:fensulkal; D010653:Phenylbutazone
vernacular_title: Protivovospalitel'naia aktivnost' fensukala.