Vascular remodeling in experimentally induced subacute canine pulmonary hypertension.
We quantified in vivo pulmonary vascular remodeling in a large animal model of pulmonary hypertension (PH). In group PH (n = 6), 3 mg/kg dehydromonocrotaline (DHMC) was administered to 12-week-old beagles via a right atrial injection. Eight weeks after DHMC in group PH, pulmonary artery pressure increased significantly (P < .05) from 18 +/- 2 mm Hg at baseline to 30 +/- 4 mm Hg. Medial wall thickness and medial wall area as a percentage of total vessel diameter or area was significantly higher (P < .05) in group PH (29 +/- 9% and 48 +/- 12%) than in a control group (n = 5) (7 +/- 1% and 14 +/- 1%). Neointimal proliferation was observed in 42% of pulmonary arterioles in the PH group but never in the control group. We conclude that a single injection of DHMC in young beagles, in addition to the development of moderate degrees of PH after 8 weeks, causes significant pulmonary vascular remodeling, with features similar to those observed in patients with primary PH.
Gust
R
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Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Schuster
D P
DP
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D006439:Hemodynamics; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D016686:Monocrotaline / Q000031:analogs & derivatives; D011651:Pulmonary Artery / Q000473:pathology; D011652:Pulmonary Circulation
C014114:monocrotaline pyrrole; D016686:Monocrotaline