[Effect of the sympathetic nervous system activation on the antifibrillatory efficacy of various anti-arrhythmia agents].
Experiments with a 7-min occlusion followed by reperfusion of the left coronary artery in narcotized rats showed that antiarrhythmic drugs of various classes--ethacizin (class I), AL-275 (class III), and CM-345 (class V)--produce pronounced antifibrillatory and antiarrhythmic effects. AL-275 and CM-345, in contrast to ethacizin, retained their efficacy under the conditions of isoproterenol-induced stimulation of beta-adrenoceptors. This difference in behavior is probably explained by dissimilar effects of the antiarrhythmics on the ion channels of cardiomyocite membranes.
Kaverina
N V
NV
Laboratory of Circulation System Pharmacology, Institute of Pharmacology, Russian Academy of Medical Sciences, Baltiiskaya ul. 8, Moscow, 125315 Russia.
Chichkanov
G G
GG
Tsorin
I B
IB
Kirsanova
G Iu
GIu
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use; D004347:Drug Interactions; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D016293:Moricizine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D051381:Rats; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000494:pharmacology / Q000627:therapeutic use; D013564:Sympathetic Nervous System / Q000502:physiology*; D014693:Ventricular Fibrillation / Q000188:drug therapy* / Q000503:physiopathology
C111159:2-(2-(diethylamino)ethyl)thio-5-ethoxybenzimidazole; D000318:Adrenergic beta-Agonists; D000889:Anti-Arrhythmia Agents; D001562:Benzimidazoles; D013438:Sulfhydryl Compounds; C027240:diethylamino-ethmozine; D016293:Moricizine; D007545:Isoproterenol
Vliianie aktivatsii simpaticheskoĭ nervnoĭ sistemy na antifibrilliatornoe deĭstvie protivoaritmicheskikh sredstv raznykh klassov.