Does body mass index of infertile women have an impact on IVF procedure and outcome?
OBJECTIVE
The objective was to explore whether body mass index (BMI) of women related to the different parameters of the in vitro fertilization (IVF) procedure and outcome.


METHODS
This retrospective study on 398 couples analyzed epidemiological features, characteristics of ovarian stimulation, number and quality of retrieved oocytes, as well as pregnancy outcome according to three groups of BMI values: BMI < 20, 20 < or = BMI < 25 and BMI > or = 25 kg/m2.


RESULTS
The prevalence of underweight and overweight women was 21.8% and 22.3%, respectively. The mean ratio follicle-stimulating hormone-luteinizing hormone increased significantly according to BMI. An increase in the mean number of consummated gonadotropin ampoules together with a decrease in the number of collected oocytes was observed in long stimulating protocol cycles when BMI > or = 25 kg/m2. The same observations were made in short stimulation protocol cycles of BMI < 20 and > or = 25 kg/m2. No significant difference could be found in clinical pregnancy and miscarriage rates between underweight, normal weight, and overweight patients.


CONCLUSIONS
Both underweight and overweight have negative effects on IVF parameters and outcome leading to decreased chances of pregnancy.
Wittemer
C
C
Infertility Centre, Department of Gynaecology and Obstetrics, Centre Médico-Chirurgical et Obstétrical (SIHCUS), 19 Rue Louis Pasteur, BP 120, 67303 Schiltigheim, France.
Ohl
J
J
Bailly
M
M
Bettahar-Lebugle
K
K
Nisand
I
I
D000328:Adult; D015992:Body Mass Index; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004958:Estradiol / Q000032:analysis; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000628:therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008596:Menotropins / Q000008:administration & dosage; D009865:Oocytes / Q000166:cytology; D010053:Ovary / Q000502:physiology; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000453:epidemiology*; D011272:Pregnancy, Multiple; D012189:Retrospective Studies
D006063:Chorionic Gonadotropin; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone