title: Efficacy of polyvinylpolypyrrolidone in reducing the immunotoxicity of aflatoxin in growing broilers.
abstract: 1. Protective action of an enzyme-linked polyvinylpolypyrrolidone (PVPP, Mycofix Plus) against the immunosuppressive effect of afatoxins (AF) was evaluated by determination of peripheral blood T-lymphocyte proportions and splenic plasma cell counts. Histological changes in lymphoid organs were also investigated by light microscopy. One-d-old broiler chicks (Hybro) received 2.5 mg/kg diet AF (83.06% AFB1, 12.98% AFB2, 2.84% AFG1, 1.12% AFG2) with or without PVPP (3g/kg diet) until 21 d of age. When compared with controls, AF treatment significantly decreased peripheral T-lymphocyte counts. AF caused a slight decrease in splenic plasma cell counts. The addition of PVPP to an AF-containing diet significantly increased T-lymphocyte counts. Splenic plasma cell counts were numerically intermediate between control and AF groups.  3. The dietary addition of PVPP to AF-free diet did not significantly alter either T-lymphocyte or splenic plasma cell counts.
authors.affiliation: University of Selçuk, Faculty of Veterinary Medicine, Konya, Turkey.
authors.forename: I
authors.initials: I
authors.lastname: Celik
authors.forename: H
authors.initials: H
authors.lastname: Oğuz
authors.forename: O
authors.initials: O
authors.lastname: Demet
authors.forename: H H
authors.initials: HH
authors.lastname: Dönmez
authors.forename: M
authors.initials: M
authors.lastname: Boydak
authors.forename: E
authors.initials: E
authors.lastname: Sur
mesh_terms: D016604:Aflatoxin B1 / Q000097:blood / Q000276:immunology* / Q000633:toxicity; D000818:Animals; D001230:Aspergillus / Q000737:chemistry; D002060:Bursa of Fabricius / Q000737:chemistry / Q000473:pathology; D002645:Chickens / Q000276:immunology*; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D007108:Immune Tolerance / Q000187:drug effects*; D018655:Lymphocyte Count / Q000662:veterinary; D008221:Lymphoid Tissue / Q000737:chemistry / Q000187:drug effects / Q000473:pathology*; D008297:Male; D011205:Povidone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D011897:Random Allocation; D013154:Spleen / Q000737:chemistry / Q000473:pathology; D013950:Thymus Gland / Q000737:chemistry / Q000473:pathology
chemical_list: C077842:polyvinylpolypyrrolidone; D016604:Aflatoxin B1; D011205:Povidone