title: A study to evaluate the field efficacy of ivermectin, fenbendazole and pyrantel pamoate, with preliminary observations on the efficacy of doramectin, as anthelmintics in horses.
abstract: The efficacy of ivermectin, fenbendazole, pyrantel pamoate and doramectin was evaluated under field conditions at 2 sites in the Free State Province of South Africa. The study involved 25 horses at each site, divided into 5 groups of equal size. Ivermectin, fenbendazole and pyrantel pamoate were administered orally at doses of 0.2, 10 and 19 mg/kg respectively. Doramectin was administered by intramuscular injection at a dose of 0.2 mg/kg. Treatment efficacy was based on the mean faecal egg count reduction 14 days post treatment. At site A a faecal egg count reduction of 100% was found after treatment with ivermectin, fenbendazole and doramectin. A 96.1% reduction was found after treatment with pyrantel pamoate. At site B ivermectin and doramectin produced a 100% reduction in faecal egg counts, fenbendazole produced an 80.8% reduction and pyrantel pamoate a 94.1% reduction. Doramectin produced a 100% reduction in faecal egg counts at both sites, despite not being registered for use in horses. In addition, the results indicated reduced efficacy of fenbendazole at site B, which suggested benzimidazole resistance. Larval cultures showed that cyathostomes accounted for between 86 and 96% of pre-treatment parasite burdens at both sites. Other helminths identified in the faecal samples were Strongylus spp. and Trichostrongylus axei.
authors.affiliation: Equine Veterinary Practice, Shelbyville, KY 40066, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Davies
authors.forename: L M
authors.initials: LM
authors.lastname: Schwalbach
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D005243:Feces / Q000469:parasitology; D005273:Fenbendazole / Q000627:therapeutic use; D006734:Horse Diseases / Q000188:drug therapy* / Q000469:parasitology; D006736:Horses; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D007559:Ivermectin / Q000031:analogs & derivatives / Q000627:therapeutic use; D010270:Parasite Egg Count / Q000662:veterinary; D011716:Pyrantel Pamoate / Q000627:therapeutic use; D017206:Strongylida Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D013320:Strongyloidea / Q000302:isolation & purification; D013323:Strongylus / Q000302:isolation & purification; D016896:Treatment Outcome; D014254:Trichostrongylus / Q000302:isolation & purification
chemical_list: D000871:Anthelmintics; D005273:Fenbendazole; D007559:Ivermectin; D011716:Pyrantel Pamoate; C084101:doramectin