[Effect of gestagen therapy on clinical and biochemical parameters in patients with atypical endometrial hyperplasia].
The investigation involved 22 reproductive and menopausal women (aged 30-48) with atypical endometrial hyperplasia. In addition to general clinical examination, all the patients underwent ultrasound scanning of the organs of the small pelvis, hysteroscopy and diagnostic curettage for morphological examination both before and after treatment. All tissue samples taken before and after treatment were assayed for cytoplasmic and plasma-membrane receptor levels and a number of biochemical parameters of plasma membranes. Hormone therapy with prolonged-release gestagen-based drugs pointed to changes which occurred in: (1) sex steroid reception at cytosol and plasma-membrane levels; (2) the lipids profile of plasma membranes, and (3) activity of membrane-related enzymes. Among the beneficial results of gestagen treatment was coming most of lipid profile parameters and plasma-membrane enzymes back to normal. However, a decrease in the progesterone reception level in target tissue after 3-6 month treatment may suggest a likelihood of development of tolerance to gestagen. The data also suggest that further research continue in this area of endometrial precancer.
Makarov
O V
OV
Russian State Medical University, Moscow.
Sergeev
P V
PV
Sviridov
N K
NK
Kareva
E N
EN
Isaeva
E G
EG
Mgdesian
K K
KK
Kirpichnikova
N V
NV
D000328:Adult; D002462:Cell Membrane / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004361:Drug Tolerance; D004714:Endometrial Hyperplasia / Q000097:blood / Q000175:diagnosis* / Q000188:drug therapy* / Q000473:pathology; D016889:Endometrial Neoplasms / Q000517:prevention & control*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008875:Middle Aged; D011372:Progestins / Q000627:therapeutic use*; D011980:Receptors, Progesterone / Q000378:metabolism; D016896:Treatment Outcome
D011372:Progestins; D011980:Receptors, Progesterone
Vliianie gestagenoterapii na klinicheskie i biokhimicheskie parametry u bol'nykh s atipicheskoĭ giperplazieĭ éndometriia.