Depression does not influence basal ganglia-mediated psychomotor speed in HIV-1 infection.
The authors examined the effects of depressive mood (Hamilton Rating Scale for Depression [Ham-D]) on basal ganglia-mediated psychomotor speed (motor test battery) in 202 HIV-1 seropositive homosexual males with no prior history of antiretroviral treatment. HIV-1 seropositive patients showed a significant slowing of most rapid alternating movements (MRAM) and significantly prolonged contraction times (CT) compared with 66 HIV-1 seronegative male control subjects. Factor analysis of Ham-D scores isolated a factor containing the items depressed mood, suicide, and psychic and somatic anxiety. This factor did not correlate with MRAM or CT. Depression and psychomotor speed are independent in HIV-1infection.
von Giesen
H J
HJ
Department of Neurology, Heirich Heine University, Duesseldorf, Germany. giesenhj@uni-duesseldorf.de
Bäcker
R
R
Hefter
H
H
Arendt
G
G
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000523:psychology; D000328:Adult; D001008:Anxiety Disorders / Q000175:diagnosis / Q000523:psychology; D003866:Depressive Disorder / Q000175:diagnosis* / Q000523:psychology; D003937:Diagnosis, Differential; D006679:HIV Seropositivity / Q000175:diagnosis* / Q000523:psychology; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D010555:Personality Inventory; D011596:Psychomotor Disorders / Q000175:diagnosis* / Q000523:psychology; D011930:Reaction Time