[Treatment of experimental corneal injuries by dioxidine and urotropin solutions].
The efficiency of 1% dioxidine and 5% urotropin solutions in suppurative penetrating corneal wounds was studied in 2 experimental series on 54 rabbits. In series A toxic effects of these drugs on eyeball tissues were studied on 6 rats, in series B drug effects were studied on a model of suppurative penetrating corneal wounds. A 21-day course of therapy with these drugs (instillations and subconjunctival parabulbar injections) caused no toxic changes in ocular tissues. Therapy with 1% dioxidine and 5% urotropin accelerated clinical cure by 4-6 days in comparison with other methods of treatment. Clinical cure was observed 3-5 days sooner after combined use of both drugs in comparison with their individual application, during during combined use their antibacterial effect was synergistic. Hence, a combination of 1% dioxidine and 5% urotropin solutions is an effective method for treating suppurative penetrating wounds of the cornea.
Musaev
P I
PI
Mamedov
L A
LA
Karaeva
G Z
GZ
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003315:Cornea / Q000382:microbiology / Q000473:pathology; D065306:Corneal Injuries; D004359:Drug Therapy, Combination; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D015807:Eye Injuries, Penetrating / Q000188:drug therapy* / Q000473:pathology; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D008709:Methenamine / Q000008:administration & dosage*; D011810:Quinoxalines / Q000008:administration & dosage*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology; D013211:Staphylococcus aureus / Q000302:isolation & purification / Q000472:pathogenicity; D014946:Wound Infection / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology
D000900:Anti-Bacterial Agents; D011810:Quinoxalines; C001077:dioxidine; D008709:Methenamine
Lechenie travm rogovitsy rastvorami dioksidina i urotropina v éksperimente.