title: Cardiopulmonary effects of sevoflurane in Garnett's greater bush baby (Otolemur garnettii).
abstract: OBJECTIVE
  A study was conducted to assess the cardiopulmonary and anesthetic effects of sevoflurane anesthesia on Garnett's Greater Bush Baby (Otolemur garnettii).
  
  
  METHODS
  Anesthesia was induced in ten animals with 8% sevoflurane and was maintained by use of 2.5% sevoflurane for 30 minutes. Induction and recovery times were recorded. Heart and respiratory rates (RR), end-tidal carbon dioxide concentration (ET CO2), arterial blood pressures, relative arterial blood oxygen saturation (SpO2), arterial partial pressure of oxygen (PaO2), arterial partial pressure of carbon dioxide (PaCO2), and pH were monitored. Pre- and poststudy CBC and serum biochemical values were compared.
  
  
  RESULTS
  Anesthesia induction was rapid (75+/-8.7 seconds [mean +/- SEM]) and smooth. Heart rate significantly increased initially, then decreased significantly over the remaining 30 minutes. There were no significant changes in RR, SpO2, ETCO2, or arterial blood pressure. The PaO2 values significantly increased in the 10- to 30-minute samples. The PaCO2 values remained steady in the 10- to 30-minute samples. A significant decrease was seen in white blood count, calcium, and total protein (TP) values, compared with values in pre-anesthesia samples. Recovery from anesthesia was smooth and rapid, with extubation at 24+/-5.8 seconds.
  
  
  CONCLUSIONS
  At the concentrations used in this study, sevoflurane appears to be a safe and effective agent for induction and maintenance of anesthesia in O. garnettii.
authors.affiliation: Department of Comparative Medicine, College of Veterinary Medicine, The University of Tennessee, Knoxville 37901-1071, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Langan
authors.forename: R C
authors.initials: RC
authors.lastname: Harvey
authors.forename: D
authors.initials: D
authors.lastname: O'Rourke
authors.forename: M B
authors.initials: MB
authors.lastname: Fontenot
authors.forename: J
authors.initials: J
authors.lastname: Schumacher
mesh_terms: D000769:Anesthesia, Inhalation / Q000379:methods / Q000662:veterinary*; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D005701:Galago; D006339:Heart Rate / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D015656:Respiratory Mechanics / Q000187:drug effects*; D012449:Safety; D000077149:Sevoflurane; D013997:Time Factors
chemical_list: D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D002245:Carbon Dioxide; D000077149:Sevoflurane; D010100:Oxygen