Vestibular and cochlear toxicity of aminoglycosides--a review.
Recently, there have been many reports describing the efficacy of intratympanic aminoglycoside injection for the treatment of intractable vertigo in patients with Ménière's disease. However, the number of injections and the amount of drug injected varies, with concomitant variation in the side-effect of hearing deterioration. To identify drugs that are more selectively vestibulotoxic, we have reviewed the ototoxicity of aminoglycosides, focusing on differences between vestibulo- and cochleotoxicity. At present, the basis for the different effects of each drug is unknown. The mechanisms of vestibulo- and cochleotoxicity are deemed worthy of further study.
Nakashima
T
T
Department of Otorhinolaryngology, Nagoya University School of Medicine, Japan. tsutomun@tsuru.med.nagoya-u.ac.jp
Teranishi
M
M
Hibi
T
T
Kobayashi
M
M
Umemura
M
M
D000617:Aminoglycosides / Q000009:adverse effects* / Q000493:pharmacokinetics; D003051:Cochlea / Q000378:metabolism; D015834:Cochlear Diseases / Q000139:chemically induced*; D004272:DNA, Mitochondrial; D006801:Humans; D009154:Mutation; D014018:Tissue Distribution; D015837:Vestibular Diseases / Q000139:chemically induced*; D014722:Vestibule, Labyrinth / Q000378:metabolism
D000617:Aminoglycosides; D004272:DNA, Mitochondrial