Blood brain barrier and infection.
The blood brain barrier (BBB) is a highly dynamic structure and consists of endothelial cells, which are characterized by the presence of tight junctions and relative lack of endocytic vesicles. The tight junctions are reinforced by the foot processes of the astrocytes. The BBB functions through these specialised structures, to maintain the environment of the brain in a steady state by regulating the influx and efflux of substances. The protective effect of the BBB is however, lost during bacterial and viral infections. The primary mechanism operative are an increase in the permeability of the BBB and/or direct invasion of the brain by microorganisms. Since the BBB is relatively impermeable to chemotherapeutic agents the treatment of CNS infections is difficult. This paper aims to examine the various mechanisms by which infection spreads to the brain, and suggest measures for successful drug delivery into the brain during infections.
Chaudhuri
J D
JD
Department of Anatomy, Faculty of Medicine, University Malaya, 50603 Kuala Lumpur, Malaysia. joydeep@medicine.med.um.edu.my
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage; D001693:Biological Transport, Active; D015415:Biomarkers / Q000032:analysis; D001812:Blood-Brain Barrier / Q000502:physiology*; D002494:Central Nervous System Infections / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D008954:Models, Biological; D010539:Permeability; D010873:Pinocytosis; D019108:Tight Junctions / Q000502:physiology
D000890:Anti-Infective Agents; D015415:Biomarkers