Selenoprotein P.
Selenoprotein P (SeP) is an extracellular, monomeric glycoprotein containing up to 10 selenocysteine residues in the polypeptide chain. It is ubiquitously expressed in mammalian tissues, and in human plasma it accounts for at least 40% of the total selenium concentration. SeP binds to heparin and cell membranes, and is associated with endothelial cells. SeP in human plasma protects against peroxynitrite-mediated oxidation and reduces phospholipid hydroperoxide in vitro, in accordance with the presumption that it has a function as an extracellular oxidant defense. Immunochemical assays have demonstrated that its concentration in plasma varies much with selenium intake, but other factors also have an influence.
Moschos
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Division of Biomedical Nutrition, Center for Chemistry and Chemical Engineering, Lund University, Sweden. marie.persson@kc.lu.se
D000375:Aging / Q000502:physiology; D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D004032:Diet; D005060:Europe; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000378:metabolism; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000097:blood / Q000737:chemistry / Q000209:etiology; D016017:Odds Ratio; D011506:Proteins / Q000032:analysis / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D012307:Risk Factors; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000737:chemistry / Q000378:metabolism; D051149:Selenoprotein P; D051140:Selenoproteins; D012727:Sex Characteristics; D012907:Smoking / Q000009:adverse effects
D001798:Blood Proteins; D011506:Proteins; D051149:Selenoprotein P; D051140:Selenoproteins; D005979:Glutathione Peroxidase; D012643:Selenium