title: [Role of biological defects in formation and development of bronchial asthma and potentialities of premorbid diagnosis].
abstract: The paper considers bronchial asthma as a polygenic disease. It presents some data available in the literature on the role of genetic disorders in the development of atopic states and the authors' own findings of various biological defects detected in apparently healthy blood relatives of patients with bronchial asthma. It is concluded that premorbid diagnosis is of importance in high risk persons.
authors.forename: G B
authors.initials: GB
authors.lastname: Fedoseev
authors.forename: A V
authors.initials: AV
authors.lastname: Emel'ianov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Lototskiĭ
authors.forename: V N
authors.initials: VN
authors.lastname: Marchenko
authors.forename: V N
authors.initials: VN
authors.lastname: Mineev
authors.forename: V I
authors.initials: VI
authors.lastname: Nemtsov
authors.forename: M A
authors.initials: MA
authors.lastname: Petrova
authors.forename: T M
authors.initials: TM
authors.lastname: Sinitsina
authors.forename: A A
authors.initials: AA
authors.lastname: Totolian
authors.forename: V I
authors.initials: VI
authors.lastname: Trofimov
authors.forename: N L
authors.initials: NL
authors.lastname: Shaporova
mesh_terms: D001249:Asthma / Q000175:diagnosis* / Q000235:genetics*; D018450:Disease Progression; D004781:Environmental Exposure / Q000009:adverse effects; D020022:Genetic Predisposition to Disease; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000235:genetics; D011379:Prognosis
vernacular_title: Rol' biologicheskikh defektov v formirovanii i razvitii bronkhial'noĭ atmy i vozmozhnosti premorbidnoĭ diagnostiki.