Phlegmonous colitis: a specific and severe complication of chronic hepatic disease.
Phlegmonous colitis (PC) is an acute infectious entity caused by bacteria. In this study, we reviewed 8,822 autopsy cases and found 13 cases of PC (0.15%). PC affected 2.43% of patients with hepatic cirrhosis or subacute liver atrophy, both of which were considered to be due to hepatitis viral infection. Before autopsy, none of the cases studied was suspected to involve PC, irrespective of the immediate cause of patient death. Thirteen autopsy cases showed some or all of the following pathohistologic characteristics: (1) involvement of the cecum (9 cases, 76.9%), (2) phlegmonous inflammatory changes and edema in the submucosa (100%), (3) bacterial infection (100%), (4) no microscopically detectable mucosal injuries (12 cases, 92.3%), and (5) acute serositis (peritonitis) (2 cases, 15.4%). These results suggest that PC is an unrecognized, but fatal complication of patients with some hepatic diseases and that PC has pathohistologic characteristics in common with previously reported spontaneous bacterial peritonitis in animal models. PC probably arises due to spontaneous infection in patients with hepatic cirrhosis.
Satoh
T
T
Department of Pathology, Saga Medical School, Japan. satoht2@post.saga-med.ac.jp
Sasatomi
E
E
Wu
L
L
Tokunaga
O
O
D000328:Adult; D000368:Aged; D001284:Atrophy; D001424:Bacterial Infections / Q000473:pathology; D002908:Chronic Disease; D003092:Colitis / Q000209:etiology / Q000382:microbiology* / Q000473:pathology; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D006525:Hepatitis, Viral, Human / Q000150:complications; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000150:complications; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology