title: Effects of exposing the opened endolymphatic sac to large doses of steroids to treat intractable Meniere's disease.
abstract: To enhance the effect of treatment for intractable Meniere's disease, we exposed the opened endolymphatic sac to high concentrations of steroids. This technique--endolymphatic sac drainage and steroid instillation surgery--involves the application of a mass of prednisolone followed by absorbable gelatin sponges soaked in a high concentration of dexamethasone into a sac lumen opened and expanded with a bundle of absorbable gelatin film. These sponges are also placed around the sac and coated with biochemical adhesive so that the medicine is slowly delivered into the sac over a prolonged period of time by means of a natural sustained-release vehicle. The short-term results (6 to 14 months) in 12 patients with Meniere's disease, including those in stage IV, treated by the above techniques showed that definitive spells were completely controlled in all cases. Hearing was improved, and annoyance due to tinnitus was decreased in all cases except one.
authors.affiliation: Department of Otolaryngology, Osaka Rosai Hospital, Sakai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kitahara
authors.forename: N
authors.initials: N
authors.lastname: Takeda
authors.forename: Y
authors.initials: Y
authors.lastname: Mishiro
authors.forename: T
authors.initials: T
authors.lastname: Saika
authors.forename: M
authors.initials: M
authors.lastname: Fukushima
authors.forename: S
authors.initials: S
authors.lastname: Okumura
authors.forename: T
authors.initials: T
authors.lastname: Kubo
mesh_terms: D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D003907:Dexamethasone / Q000627:therapeutic use*; D004322:Drainage / Q000379:methods*; D004712:Endolymphatic Sac / Q000187:drug effects* / Q000601:surgery*; D004713:Endolymphatic Shunt / Q000379:methods*; D005260:Female; D005500:Follow-Up Studies; D005780:Gelatin; D006801:Humans; D007322:Instillation, Drug; D008297:Male; D008575:Meniere Disease / Q000145:classification / Q000175:diagnosis / Q000628:therapy*; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use*; D012720:Severity of Illness Index; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D003907:Dexamethasone; D005780:Gelatin; D011239:Prednisolone