title: Blasticidin A as an inhibitor of aflatoxin production by Aspergillus parasiticus.
abstract: Blasticidin A, an antibiotic, showed strong inhibitory activity toward aflatoxin production by Aspergillus parasiticus. Its structure was characterized by NMR and chemical degradation experiments as 1, which is a tetramic acid derivative with a highly oxygenated long alkyl chain similar to aflastatin A (2). Absolute configurations of the eight chiral centers at C-4, 6, 31, 32, 33, 34, 35 and 37 of 1 were chemically determined. Blasticidin A almost completely inhibited aflatoxin production at 0.5 microM.
authors.affiliation: Department of Applied Biological Chemistry, The University of Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sakuda
authors.forename: M
authors.initials: M
authors.lastname: Ono
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: Y
authors.initials: Y
authors.lastname: Inagaki
authors.forename: R
authors.initials: R
authors.lastname: Kawachi
authors.forename: J
authors.initials: J
authors.lastname: Nakayama
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Isogai
authors.forename: H
authors.initials: H
authors.lastname: Nagasawa
mesh_terms: D000348:Aflatoxins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects* / Q000378:metabolism; D015394:Molecular Structure; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000348:Aflatoxins; D000900:Anti-Bacterial Agents; D011760:Pyrrolidinones; C420726:blasticidin A