Inhibitory effect of dietary inulin or oligofructose on the development of cancer metastases.
The possible influence of continuous dietary treatment with 15% inulin or oligofructose on the development of lung metastases of a transplantable liver tumor in young male C3H mice was investigated. Microscopical examination demonstrated a distinct inhibitory effect of this dietary treatment on the development of lung metastases of this tumor. There were 59% of mice bearing lung metastases in the control group, 36% in the inulin fed group and 35% in the oligofructose fed group. The total number of lung metastases was 37 in the control group, 18 in inulin fed and 6 in oligofructose fed mice. Several possible, mechanisms hypothetically involved in this astonishing inhibition of the development of lung metastases by dietary treatment with inulin or oligofructose are discussed.
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Unité de Pharmacocinétique, Métabolisme, Nutrition et Toxicologie, Université Catholique de Louvain, Avenue Em. Mounier, 73,UCL/PMNT 7369, B 1200 Bruxelles, Belgium. ferdinand@pmnt.ucl.ac.be
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D000818:Animals; D004354:Drug Screening Assays, Antitumor; D007444:Inulin / Q000008:administration & dosage / Q000494:pharmacology*; D008113:Liver Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009844:Oligosaccharides / Q000008:administration & dosage / Q000494:pharmacology*
D009844:Oligosaccharides; C120489:oligofructose; D007444:Inulin