title: Lowering of circulating insulin and leptin is closely associated following weight reduction after vertical banded gastroplasty in obese women.
abstract: OBJECTIVE
  To explore whether the lowering of insulin relates to changes in leptin following weight reduction after vertical banded gastroplasty (VBG) in seven grossly obese women (BMI 45.9 +/- 1.5 kg/m2).
  
  
  RESULTS
  At 6-24 months after VBG, BMI was reduced to 31.3 +/- 0.9 kg/m2 (p < 0.018), leptin from 43 +/- 9 to 12 +/- 2 ng/ml (p < 0.018) and insulin from 172 +/- 19 to 71 +/- 2 pmol/l (p=0.018). The reduction in leptin correlated to the reduction in insulin (r = 0.94, p = 0.002) but not to that of BMI (r = 0.05, NS).
  
  
  CONCLUSIONS
  Reduction in insulin seems more important for reduction in leptin than lowering of BMI, suggesting a close association between leptin and insulin in obese subjects.
authors.affiliation: Department of Medicine, Danderyd Hospital, Malmö, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Guldstrand
authors.forename: L
authors.initials: L
authors.lastname: Backman
authors.forename: U
authors.initials: U
authors.lastname: Adamson
authors.forename: P E
authors.initials: PE
authors.lastname: Lins
authors.forename: B
authors.initials: B
authors.lastname: Ahrén
mesh_terms: D000328:Adult; D015992:Body Mass Index; D005260:Female; D015391:Gastroplasty / Q000379:methods; D006801:Humans; D007328:Insulin / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000601:surgery*; D011184:Postoperative Period; D015431:Weight Loss
chemical_list: D007328:Insulin; D020738:Leptin