title: Effect of black tea on lipid peroxide and glutathione levels in female rats.
abstract: The effects of black tea (Camellia sinensis L.) on lipid peroxidation and glutathione (GSH) levels in carbon tetrachloride (CCl4)-treated female Wistar rats were examined. Two control groups and one treatment group were tested. The control groups were fed with a standard diet, while the black tea group was fed the standard diet plus 6% by weight dried black tea leaves. At the end of 2 months, a single dose of CCl4 (1 ml/kg, i.p.) in olive oil was administered to rats in one of the control groups and the black tea group. They were sacrificed after 2 hours. Rats in the other control group were administered olive oil in a similar fashion. Measurements were made of lipid peroxide levels in liver and plasma, glutathione levels in liver, and alanine transaminase (ALT) and aspartate transaminase (AST) activities in plasma. Liver lipid peroxide levels, plasma ALT and AST activities were significantly decreased in the black tea group compared with the CCl4-treated control group, while plasma lipid peroxide levels were not. These results are parallel to those previously found with Wistar male rats. Glutathione levels, however, were not significantly affected, in contrast to the data relating to male rats, either after CCl4 or black tea treatments. The results of our study add to the findings that black tea attenuates CCl4-induced hepatic injury but also indicates the susceptibility of glutathione levels to endocrinological effects.
authors.affiliation: Department of Biochemistry, Faculty of Pharmacy, Marmara University, Haydarpaşa 81010, Istanbul, Turkey.
authors.forename: D
authors.initials: D
authors.lastname: Sür-Altiner
authors.forename: B
authors.initials: B
authors.lastname: Yenice
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000032:analysis*; D006801:Humans; D008054:Lipid Peroxides / Q000032:analysis*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012737:Sex Factors; D013662:Tea / Q000378:metabolism*
chemical_list: D008054:Lipid Peroxides; D013662:Tea; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione