[Development of gene therapy for pancreatic cancer].
In order to develop the new therapeutic intervention for pancreatic cancer, we have examined the effect of gene therapy for this miserable pancreatic disease. The transfection of UPRT, a 5-FU converting enzyme, gene resulted in the significant change in sensitivity of pancreatic cancer cells against 5-FU. Anti-angiogenesis gene therapy has been also demonstrated to be a promising strategy for pancreatic cancer. It has been revealed that replication-competent adenoviruses are not only the strong weapon themselves but also useful carriers of genes possessing anti-tumor activities as virus vectors specific to tumors without normal p53 function nor intact Rb pathway. Whether these experimental results are universally true require the clinical trials in future.
Sunamura
M
M
First Department of Surgery, Tohoku University School of Medicine.
Motoi
F
F
Onuma
M
M
Abe
H
H
Matsuno
M
M
D000256:Adenoviridae / Q000235:genetics; D020533:Angiogenesis Inhibitors; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D016326:Extracellular Matrix Proteins / Q000235:genetics; D016158:Genes, p53; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D006801:Humans; D018664:Interleukin-12 / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000628:therapy*; D010430:Pentosyltransferases / Q000235:genetics; D011506:Proteins / Q000235:genetics; D051901:Smad4 Protein; D015534:Trans-Activators / Q000235:genetics
D020533:Angiogenesis Inhibitors; D004268:DNA-Binding Proteins; D016326:Extracellular Matrix Proteins; D011506:Proteins; C497796:SMAD4 protein, human; D051901:Smad4 Protein; D015534:Trans-Activators; D018664:Interleukin-12; D010430:Pentosyltransferases; C023269:uracil phosphoribosyltransferase