title: Intranasal administration of fusidic acid cream in leprosy.
abstract: The effect of local treatment of nostrils with fusidic acid cream was investigated in 30 previously untreated lepromatous leprosy patients. The cream was applied in the nostrils after flushing the nostrils with normal saline, twice a day for a period of four weeks. It was found that 20 mg/gm of sodium fusidate was effective in reducing the morphological index of the nose-blow smear to zero in two weeks in majority of the patients. No untoward side effect was seen in any of the patients. Such nasal treatment along with multidrug therapy may help in reducing the patient's level of infectiousness to their contacts, since the nose is recognized to be an important portal of exit of M. leprae.
authors.forename: P M
authors.initials: PM
authors.lastname: Mahajan
authors.forename: V H
authors.initials: VH
authors.lastname: Jadhav
authors.forename: D G
authors.initials: DG
authors.lastname: Jogaikar
authors.forename: J M
authors.initials: JM
authors.lastname: Mehta
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005672:Fusidic Acid / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D015440:Leprosy, Lepromatous / Q000188:drug therapy* / Q000382:microbiology; D008297:Male; D009166:Mycobacterium leprae / Q000187:drug effects*; D009297:Nasal Mucosa / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D007917:Leprostatic Agents; D005672:Fusidic Acid