title: Parameters of microsomal and cytosolic liver function but not of liver perfusion predict portal vein velocity in noncirrhotic patients with chronic hepatitis C.
abstract: Our aim was to compare color-coded Doppler sonography (CCDS) and quantitative testing of liver function (QTLF) in patients with chronic hepatitis C. In all, 74 patients with chronic hepatitis C and mild fibrosis underwent QTLF, which included aminopyrine breath test (ABT), galactose elimination capacity (GEC), sorbitol clearance (SC), and indocyanine green clearance (ICG). Hepatic artery velocity and resistance index (HA-V, HA-RI) as well as portal vein velocity (PV-V) were measured by CCDS. ABT, GEC, and PV-V were significantly reduced, whereas SC1, ICG, HA-V, and HA-RI showed normal levels. There was a significant correlation between reduction in PV-V only with GEC and ABT. QTLF did not correlate with HA-V and HA-RI. In conclusion, in hepatitis C patients with liver fibrosis, ABT and GEC are decreased significantly, which was paralleled by a reduction of PV-V. Unexpectedly SC1 and ICG, the classical hepatic perfusion parameters, do not correlate with the parameters measured by CCDS.
authors.forename: C
authors.initials: C
authors.lastname: Herold
authors.forename: P
authors.initials: P
authors.lastname: Berg
authors.forename: D
authors.initials: D
authors.lastname: Kupfal
authors.forename: D
authors.initials: D
authors.lastname: Becker
authors.forename: D
authors.initials: D
authors.lastname: Schuppan
authors.forename: E G
authors.initials: EG
authors.lastname: Hahn
authors.forename: H T
authors.initials: HT
authors.lastname: Schneider
mesh_terms: D000368:Aged; D000632:Aminopyrine; D001783:Blood Flow Velocity / Q000502:physiology; D001944:Breath Tests; D003600:Cytosol / Q000502:physiology*; D005260:Female; D005690:Galactose; D019698:Hepatitis C, Chronic / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006801:Humans; D007208:Indocyanine Green; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008862:Microsomes, Liver / Q000502:physiology*; D008875:Middle Aged; D011169:Portal Vein / Q000000981:diagnostic imaging*; D011446:Prospective Studies; D013012:Sorbitol; D018615:Ultrasonography, Doppler, Color
chemical_list: D000632:Aminopyrine; D013012:Sorbitol; D007208:Indocyanine Green; D005690:Galactose