Eudragit matrices for sustained release of ketorolac tromethamine: formulation and kinetics of release.
Matrix type formulations with dicalcium phosphate dihydrate (DCPD) using a polymeric binder (Eudragit RSPM) to obtain controlled release of Ketorolac tromethamine (KT) has been investigated. The drug, DCPD and Eudragit RSPM were granulated using isopropyl alcohol with and without a plasticizer (Diethyl phthalate, DEP). Addition of Eudragit appear to affect the release profile. However, addition of a plasticizer had a significant effect on the rate of release. The release appears to follow first order kinetics and the rate constant decreased linearly with increasing DEP concentration. A directly compressible mixture was also formulated by coating DCPD particles with DEP with and without Eudragit RSPM.
Ruckmani
K
K
Periyar College of Pharmaceutical Sciences for Girls, Trichy-21.
Muneera
M S
MS
Vijaya
R
R
D000180:Acrylic Resins / Q000737:chemistry*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D005079:Excipients; D020911:Ketorolac Tromethamine / Q000008:administration & dosage*; D007700:Kinetics; D010968:Plasticizers; D011109:Polymethacrylic Acids; D012995:Solubility; D013607:Tablets
D000180:Acrylic Resins; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D005079:Excipients; D010968:Plasticizers; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D020911:Ketorolac Tromethamine