title: Bioactive oleanolic acid saponins and other constituents from the roots of Viguiera decurrens.
abstract: The bisdesmoside oleanolic acid saponin, 3-0-(methyl-beta-D-glucuronopyranosiduronoate)-28-0-beta-D-glucopyranosyl-oleanolate along with nine known compounds (two diterpenic acids, one chromene, three triterpenes, one steroidal glycoside, and two monodesmoside oleanolic acid saponins), were obtained from Viguiera decurrens roots. The chemical structure of the bisdesmoside oleanolic saponin was determined by chemical and NMR spectral evidence. A mixture of monodesmoside saponins displayed cytotoxic activity against P388 and COLON cell lines (ED50= 2.3 and 3.6 microg/ml, respectively). Two of the known compounds showed insecticidal activity against the Mexican bean beetle larvae (Epilachna varivestis).
authors.affiliation: Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico.
authors.forename: S
authors.initials: S
authors.lastname: Marquina
authors.forename: N
authors.initials: N
authors.lastname: Maldonado
authors.forename: M L
authors.initials: ML
authors.lastname: Garduño-Ramírez
authors.forename: E
authors.initials: E
authors.lastname: Aranda
authors.forename: M L
authors.initials: ML
authors.lastname: Villarreal
authors.forename: V
authors.initials: V
authors.lastname: Navarro
authors.forename: R
authors.initials: R
authors.lastname: Bye
authors.forename: G
authors.initials: G
authors.lastname: Delgado
authors.forename: L
authors.initials: L
authors.lastname: Alvarez
mesh_terms: D019659:Asteraceae / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D009682:Magnetic Resonance Spectroscopy; D009828:Oleanolic Acid / Q000737:chemistry* / Q000031:analogs & derivatives; D018517:Plant Roots / Q000737:chemistry; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
chemical_list: C422662:3-O-(methyl glucuronopyranosiduronoate)-28-O-glucopyranosyl-oleanolate; D012503:Saponins; D009828:Oleanolic Acid