Modification of corporal weight, body fat distribution, blood lipids and glucose levels in oral contraceptive users.
The association between oral contraceptives and the modification of corporal weight and body fat distribution is controversial. The characteristics of the menstrual cycle, lipids and glucose levels were also analyzed. Thirty women who received ethinylestradiol 0.035 mg and norethindrone 0.400 mg for one year were studied. The following variables were analyzed every 3 months: weight, body mass index (BMI), hip perimeter, waist perimeter, waist-hip ratio (WHR), duration of menstrual cycle, quantity of uterine bleeding, as well as blood levels of cholesterol, triglycerides and glucose. Waist and hip perimeters increased during the third evaluation; as well as the BMI starting from the second evaluation. The triglycerides levels rose from the first evaluation. No modifications were found in the WHR, glucose and cholesterol levels and the duration of the menstrual cycle, but the quantity of uterine bleeding decreased from the third month. The oral contraceptive significantly increased BMI and triglycerides level, but no changes were detected in body fat distribution, cholesterol and glucose levels. Uterine bleeding decreased from the first evaluation.
Carranza-Lira
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S
Gynecologic Endocrinology Service, Hospital de Ginecología y Obstetricia Luis Castelazo Ayala, Instituto Mexicano del Seguro Social, México. scarranzal@mexis.com
Bueno Fontal
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JP
D000273:Adipose Tissue / Q000033:anatomy & histology / Q000187:drug effects*; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D001835:Body Weight / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008597:Menstrual Cycle / Q000187:drug effects; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D003277:Contraceptives, Oral, Combined; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol