Effects of Ninjin-to on levels of brain-gut peptides (motilin, vasoactive intestinal peptide, gastrin, and somatostatin) in human plasma.
We examined the effects of Ninjin-to, a traditional Chinese (Kampo) medicine, on the levels of brain-gut peptides (motilin, vasoactive intestinal peptide (VIP), gastrin, and somatostatin) in plasma from healthy subjects. A single oral administration of Ninjin-to, at a dose of 6.0 g, caused significant increases in plasma motilin levels at 40 to 90 min and somatostatin levels at 20 to 90 min, compared with a placebo treated group. Transient elevations of gastrin levels in the placebo group were inhibited by administration of Ninjin-to, but the medicine did not alter the levels of VIP. In conclusion, these results suggest that pharmacological effects of Ninjin-to on gastrointestinal functions closely relate to changes of motilin, gastrin, and somatostatin-immunoreactive substance levels in human plasma.
Naito
T
T
Department of Clinical Pharmacy, Oita Medical University, Hasama-machi, Japan. naitou@oita-med.ac.jp
Itoh
H
H
Nagano
T
T
Takeyama
M
M
D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009037:Motilin / Q000097:blood*; D010919:Placebos; D012016:Reference Values; D013004:Somatostatin / Q000097:blood*; D014660:Vasoactive Intestinal Peptide / Q000097:blood*
D004365:Drugs, Chinese Herbal; D005755:Gastrins; D010919:Placebos; C072867:ren-shen-yang-rong-tang; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D009037:Motilin