Preformulation experiences and in vitro model studies with spironolactone-containing suppositories.
The optimal suppository base for the formulation of rectal suppositories containing diuretic spironolactone was selected experimentally. Model studies were carried out about the effect of solubility-increasing additives on the release of the drug from the suppositories. During the in vitro examinations acceptor phases of different pH values were used, and both diffusion time and the number of samplings were changed. Among the lipophilic and hydrophilic suppository bases studied the hydrophilic Macrogolum 1540 was found to be optimal. The release and diffusion of spironolactone was the most favourable from these suppositories. During storage these suppositories remained stable and the values of release did not decrease significantly (p < 0.05).
Regdon
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G
Deák
D
D
Regdon
G
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Muskó
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Z
Erös
I
I
D000465:Algorithms; D004058:Diffusion; D004339:Drug Compounding; D004355:Drug Stability; D005079:Excipients; D000451:Mineralocorticoid Receptor Antagonists / Q000008:administration & dosage*; D008954:Models, Biological; D011208:Powders; D013148:Spironolactone / Q000008:administration & dosage*; D013488:Suppositories
D005079:Excipients; D000451:Mineralocorticoid Receptor Antagonists; D011208:Powders; D013488:Suppositories; D013148:Spironolactone