title: Hypotensive infarction of the spinal cord in a rhesus macaque (Macaca mulatta).
abstract: A 6.5-year-old male rhesus macaque (Macaca mulatta) was presented with acute paraplegia following a surgical procedure. During surgery, he experienced an acute hypotensive episode that required 3 hours of supportive therapy before hemodynamic stability was restored. Paraplegia remained unchanged until euthanasia 72 hours later. At necropsy, spinal cord segments T10-S3 had acute, massive panmedullary necrosis, which involved most of the central and middle spinal cord, sparing the peripheral white matter. Additional lesions included arterial border zone necrosis of the brain, centrilobular hepatic necrosis, and proximal renal tubular necrosis. The histologic findings of central spinal cord necrosis with a preserved rim of white matter is consistent with severely decreased flow in the anterior spinal artery. Such lesions can result from episodes of generalized hypoperfusion. Possible factors contributing to the hypotensive episode in this case included the addition of xylazine to ketamine and atropine in the preanesthetic medication, positioning during anesthesia, and decreased blood pressure during surgery.
authors.affiliation: Section of Comparative Medicine, School of Medicine, Yale University, New Haven, CT 06520, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Zeiss
authors.forename: N H
authors.initials: NH
authors.lastname: Shomer
authors.forename: F R
authors.initials: FR
authors.lastname: Homberger
mesh_terms: D000316:Adrenergic alpha-Agonists / Q000009:adverse effects; D000818:Animals; D002531:Cerebellum / Q000473:pathology; D007022:Hypotension / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D007238:Infarction / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D008253:Macaca mulatta / Q000601:surgery*; D008297:Male; D008992:Monkey Diseases / Q000209:etiology / Q000473:pathology*; D009336:Necrosis; D010264:Paraplegia / Q000209:etiology / Q000473:pathology / Q000662:veterinary; D011183:Postoperative Complications / Q000662:veterinary; D013116:Spinal Cord / Q000098:blood supply* / Q000473:pathology; D014991:Xylazine / Q000009:adverse effects
chemical_list: D000316:Adrenergic alpha-Agonists; D014991:Xylazine