Synthesis and evaluation of caffeic acid amides as antioxidants.
A series of amides of caffeic acid has been synthesised and their antioxidant properties evaluated as lipid peroxidation inhibitors. Anilides of caffeic acid were found to be very efficient antioxidants with IC50's of 0.3 microM.
Rajan
P
P
Department of Medicinal Chemistry, University of Antwerpen (UIA), Belgium.
Vedernikova
I
I
Cos
P
P
Berghe
D V
DV
Augustyns
K
K
Haemers
A
A
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology; D000813:Anilides / Q000138:chemical synthesis / Q000494:pharmacology; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology; D002109:Caffeic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D020650:Combinatorial Chemistry Techniques; D005609:Free Radicals / Q000138:chemical synthesis / Q000737:chemistry; D006860:Hydrogen Bonding; D020128:Inhibitory Concentration 50; D015227:Lipid Peroxidation / Q000187:drug effects; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D000577:Amides; D000813:Anilides; D000975:Antioxidants; D002109:Caffeic Acids; D005609:Free Radicals