title: Quinolactacins A, B and C: novel quinolone compounds from Penicillium sp. EPF-6. I. Taxonomy, production, isolation and biological properties.
abstract: Quinolactacins A (1), B (2) and C (3), novel quinolone antibiotics have been found from the cultured broth of a fungal strain isolated from the larvae of the mulberry pyralid Margaronia pyloalis Welker). The fungal strain, EPF-6 was identified as Penicillium sp. from its morphological characteristics. Quinolactacins were obtained from the culture medium by solvent extraction and chromatographic purification. Compound 1 showed inhibitory activity against tumor necrosis factor (TNF) production induced by murine peritoneal macrophages and macrophage-like J774.1 cells stimulated with lipopolysaccharide (LPS).
authors.affiliation: United Graduate School of Agricultural Science, Tokyo  University of Agriculture and Technology, Fuchu, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kakinuma
authors.forename: H
authors.initials: H
authors.lastname: Iwai
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Hamano
authors.forename: T
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: K
authors.initials: K
authors.lastname: Nagai
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: F
authors.initials: F
authors.lastname: Kirikae
authors.forename: T
authors.initials: T
authors.lastname: Kirikae
authors.forename: A
authors.initials: A
authors.lastname: Nakagawa
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D005260:Female; D005285:Fermentation; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010407:Penicillium / Q000737:chemistry* / Q000648:ultrastructure; D015363:Quinolones / Q000138:chemical synthesis / Q000145:classification / Q000302:isolation & purification / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis
chemical_list: D000900:Anti-Bacterial Agents; D015363:Quinolones; D014409:Tumor Necrosis Factor-alpha; C420723:quinolactacin A; C420724:quinolactacin B; C420725:quinolactacin C