title: Increased blood-brain barrier permeability of morphine in a patient with severe brain lesions as determined by microdialysis.
abstract: Intracerebral microdialysis was utilised to obtain information regarding how morphine is transported across the blood-brain barrier (BBB). In a patient with a severe brain injury, we measured simultaneously unbound extracellular fluid (ECF) concentrations of morphine in human brain and in subcutaneous fat tissue, which were compared to morphine levels in arterial blood. This report shows an increase in morphine levels near the trauma site in the brain compared to uninjured brain tissue. The half-life of morphine in uninjured and injured brain tissue of 178 min and 169 min, respectively, were comparable but were longer than in blood (64 min) and adipose tissue (63 min). This indicates that morphine is retained in brain tissue for a longer time than what could be expected from the blood concentration-time profile. These results show the potential of the microdialysis technique in providing new information regarding the pharmacokinetics of drug in the human brain close to the trauma site and in macroscopically intact tissue.
authors.affiliation: Division of Biopharmaceutics and Pharmacokinetics, Uppsala University, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Bouw
authors.forename: P
authors.initials: P
authors.lastname: Ederoth
authors.forename: J
authors.initials: J
authors.lastname: Lundberg
authors.forename: U
authors.initials: U
authors.lastname: Ungerstedt
authors.forename: C H
authors.initials: CH
authors.lastname: Nordström
authors.forename: M
authors.initials: M
authors.lastname: Hammarlund-Udenaes
mesh_terms: D001812:Blood-Brain Barrier; D001930:Brain Injuries / Q000378:metabolism*; D006801:Humans; D008297:Male; D017551:Microdialysis; D008875:Middle Aged; D009020:Morphine / Q000493:pharmacokinetics*; D009294:Narcotics / Q000493:pharmacokinetics*; D010539:Permeability
chemical_list: D009294:Narcotics; D009020:Morphine