title: The use of autologous growth factors in periodontal surgical therapy: platelet gel biotechnology--case reports.
abstract: The role of polypeptide growth factors in periodontal regeneration has been documented through animal and human studies. Human platelets contain platelet-derived growth factor (PDGF) and transforming growth factor-beta (TGF-beta) in their alpha granules. PDGF has been shown to play a role in periodontal regeneration. It has been demonstrated that TGF-beta has a very potent effect on cells associated with bone. The case reports presented demonstrate a new biotechnology in which platelet gel is used in combination with demineralized freeze-dried bone allografts for the treatment of periodontal osseous defects. The treated teeth presented with severe bone loss and a guarded prognosis. Platelet gel biotechnology was used as a novel treatment modality. A significant reduction in probing depths was noted, and radiographically significant amounts of new bone were visible as early as 2 months postoperative. Results up to 2 years postoperative are presented.
authors.affiliation: United States Air Force, Dental Corps, Howard Air Force Base, Panama. jobarrio@sinfo.net
authors.forename: J J
authors.initials: JJ
authors.lastname: de Obarrio
authors.forename: J I
authors.initials: JI
authors.lastname: Araúz-Dutari
authors.forename: T M
authors.initials: TM
authors.lastname: Chamberlain
authors.forename: A
authors.initials: A
authors.lastname: Croston
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000000981:diagnostic imaging / Q000601:surgery*; D000539:Alveolar Process / Q000000981:diagnostic imaging; D001709:Biotechnology; D001792:Blood Platelets; D016025:Bone Transplantation; D003094:Collagen; D003648:Decalcification Technique; D005260:Female; D005500:Follow-Up Studies; D005612:Freeze Drying; D005782:Gels; D016557:Guided Tissue Regeneration, Periodontal / Q000379:methods*; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D010514:Periodontal Pocket / Q000601:surgery; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D011379:Prognosis; D011859:Radiography; D014021:Tissue Preservation; D016212:Transforming Growth Factor beta / Q000008:administration & dosage / Q000627:therapeutic use*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D014945:Wound Healing
chemical_list: D005782:Gels; D008567:Membranes, Artificial; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D003094:Collagen