The effect of delta sleep-inducing peptide on the EEG and power spectra in rat.
The effects of delta sleep-inducing peptide (DSIP) on the EEG and power spectra of adult male Wistar rats (b.w. 180-220 g) were studied by power spectra analyses of EEG wave forms recorded continuously for 12 h after DSIP administration. The animals were given DSIP i.p. (1 mg/kg). Saline-injected rats served as the corresponding control. Recorded bursts of high amplitude EEG in the 1-9 Hz range (delta and theta) were found to be more frequent in DSIP-treated animals, while power spectra and (delta) wave activity were enhanced in comparison with the control and a statistically significant increase was registered in all experimental points after DSIP (2 h P < 0.05; 4 h P < 0.05; 5 h P < 0.05; 6 h P < 0.05; 7 h P < 0.01; 11 h P < 0.05). In addition, DSIP significantly elevated both the EEG output in the (delta) range and sleep activity. These results suggest that DSIP should be considered as a potential agent for the treatment of sleep disturbances in human medicine.
Stanojlović
O P
OP
Department of Physiology, School of Medicine, University of Belgrade, 11000 Belgrade, Yugoslavia.
Zivanović
D P
DP
Susić
V T
VT
D000818:Animals; D003700:Delta Rhythm / Q000187:drug effects*; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D003701:Delta Sleep-Inducing Peptide