[One-pot synthesis of dl-naproxen by rearrangement].
OBJECTIVE
To synthesize dl-naproxen by rearrangement method.


METHODS
dl-Naproxen was synthesized by halogenation, ketalization, rearrangement and hydrolysis, using cupric halide as halogenation agent.


RESULTS
Total yields were 74.0%-92.6% based on 6-methoxy-2-propionyl naphthalene.


CONCLUSIONS
Total yield was higher by one-pot rearrangement approach.
Hu
A X
AX
College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. huaixi@mail.hunu.edu.cn
Dong
X M
XM
Cao
S C
SC
Cheng
Y P
YP
Chen
L
L
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D006868:Hydrolysis; D009288:Naproxen / Q000138:chemical synthesis*; D009942:Organometallic Compounds / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D009942:Organometallic Compounds; C015092:cupric acetate; D009288:Naproxen