title: Combined endovascular therapy of ruptured aneurysms and cerebral vasospasm.
abstract: We describe two patients with subarachnoid haemorrhage due to a ruptured intracranial aneurysm and severe symptomatic vasospasm. The aneurysm was occluded with detachable coils followed by intra-arterial infusion of papaverine to treat vasospasm as an one-stage procedure. There was significant resolution of the vasospasm. The long-term clinical outcome in one patient was excellent, the other still has minor deficits. Combined endovascular aneurysm therapy followed by intra-arterial spasmolysis with papaverine is a technically feasible therapeutic alternative in patients with symptomatic vasospasm.
authors.affiliation: Department of Neuroradiology and Department of Neurosurgery, University of Essen, Hufelandstrasse 55, Essen D-45122, Germany. isabel.wanke@uni-essen.de
authors.forename: I
authors.initials: I
authors.lastname: Wanke
authors.forename: A
authors.initials: A
authors.lastname: Dörfler
authors.forename: U
authors.initials: U
authors.lastname: Dietrich
authors.forename: T
authors.initials: T
authors.lastname: Aalders
authors.forename: M
authors.initials: M
authors.lastname: Forsting
mesh_terms: D000328:Adult; D017542:Aneurysm, Ruptured / Q000473:pathology / Q000628:therapy*; D002339:Carotid Arteries / Q000473:pathology; D002533:Cerebral Angiography; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D002532:Intracranial Aneurysm / Q000473:pathology / Q000628:therapy*; D010208:Papaverine / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D020301:Vasospasm, Intracranial / Q000188:drug therapy* / Q000209:etiology
chemical_list: D014665:Vasodilator Agents; D010208:Papaverine