title: Antimicrobial triterpenoids from Licania heteromorpha.
abstract: Six triterpenoids having a lupane and oleane skeleton were isolated from the leaves and young branches of Licania heteromorpha Bentham var. heteromorpha and were identified as: betulinic acid 1, alphitolic acid 2, 3 beta-O-trans-p-coumaroyl alphitolic acid 3, 3 beta-O-cis-p-coumaroyl alphitolic acid 4, 3 beta-O-trans-p-coumaroyl maslinic acid 5, 3 beta-O-cis-p-coumaroyl maslinic acid 6. The antimicrobial activity of these compounds was evaluated in vitro on clinically isolated microorganisms employing a microdilution method. Compounds 2, 3, 5, and 6 showed antimicrobial activity on Gram-positive bacteria and yeasts, whereas none of the six triterpenoids were active against Gram-negative organisms.
authors.forename: A
authors.initials: A
authors.lastname: Braca
authors.forename: I
authors.initials: I
authors.lastname: Morelli
authors.forename: J
authors.initials: J
authors.lastname: Mendez
authors.forename: L
authors.initials: L
authors.lastname: Battinelli
authors.forename: L
authors.initials: L
authors.lastname: Braghiroli
authors.forename: G
authors.initials: G
authors.lastname: Mazzanti
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D019685:Rosales / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D014315:Triterpenes