Application of cytology in diagnosing benign changes and breast cancers.
On the basis of cytology performed in a group of 386 women and 14 men admitted to the Breast Disease Outpatient Unit in the area of Sucha Beskidzka, a structure of changes in breast benign and malignant neoplasms was defined. The diagnostic value of cytology based on FNB and a secretion from mammary glands were evaluated. Expression of p53 and nm23 protein expression in the cells of the most common cancers was studied for prognostic values. The study demonstrated 81% of benign changes and 19% of cancers. With respect to cancers, cytology confirmed its usefulness since the findings were compatible in 94.44% with histopathologic results. Moreover, application of proliferation markers (p53 and nm23) allowed to evaluate the degree of malignancy and prognosis for further neoplastic process.
Sporek
R
R
Cytology Department, County Hospital, Sucha Beskidzka, ul. Szpitalna 22, 34-200 Sucha Beskidzka, Poland.
D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000473:pathology; D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000175:diagnosis* / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000473:pathology; D018275:Carcinoma, Lobular / Q000175:diagnosis / Q000473:pathology; D018276:Carcinoma, Medullary / Q000175:diagnosis / Q000473:pathology; D003581:Cytodiagnosis / Q000379:methods*; D005260:Female; D005348:Fibrocystic Breast Disease / Q000175:diagnosis / Q000473:pathology; D006177:Gynecomastia / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D008067:Lipoma / Q000175:diagnosis / Q000473:pathology; D008297:Male; D008875:Middle Aged; D018300:Papilloma, Intraductal / Q000175:diagnosis / Q000473:pathology; D011044:Poland