Successful pregnancy in a patient with familial sea-blue histiocyte syndrome.
A 27-year-old Indian woman at 23 weeks' gestation presented with decompensated liver cirrhosis, coagulopathy, restrictive lung disease with cor pulmonale and preeclampsia. She was diagnosed to have sea-blue histiocyte syndrome (SBHS) at the age of 13 years and was treated conservatively. There was worsening liver, respiratory and bone marrow function as the pregnancy progressed. She underwent a successful pregnancy despite her poor medical condition and advanced disease state. We described the first case of familial SBHS in a pregnant patient from Asia.
Fadilah
S A
SA
Department of Haematology and Transplantation, MAKNA-HUKM Cancer Institute, Hospital Universiti Kebangsaan Malaysia (HUKM), Jalan Yaacob Latif, Cheras, 56000 Kuala Lumpur.
Mazeni
N R
NR
Cheong
S K
SK
D000328:Adult; D005260:Female; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012618:Sea-Blue Histiocyte Syndrome / Q000235:genetics* / Q000473:pathology; D013154:Spleen / Q000473:pathology