title: Serum concentrations of organochlorines in men: a search for markers of exposure.
abstract: Analysis of single marker substances in serum could provide cost-effective assessment of human exposure to complex mixtures of organochlorines. We studied the serum concentrations of 10 polychlorinated biphenyl (PCB) congeners and 11 chlorinated pesticides and some of their metabolites in samples collected from 120 Swedish men (mean age 63 years, range 40-74 years) from the general Swedish population. The median concentrations of individual PCB congeners increased in the order PCB 52 < PCB 101 < or = PCB28 < PCB 105 < PCB 167 < PCB 156 < PCB 118 < PCB 138 < PCB 180 < PCB 153. The concentrations of o,p'-DDT, o,p'-DDE, p,p'-DDD, alpha-HCH and gamma-HCH were in most cases below the quantification limit (2-4 ng/g lipid). Among the other chlorinated pesticides the median concentration increased in the order oxychlordane (12 ng/g lipid) < p,p'-DDT < trans-nonachlor < beta-HCH < HCB < p,p'-DDE (586 ng/g lipid). The observed concentrations of PCB and chlorinated pesticides were in the same range as those found in similar groups of men from Sweden and Norway, but lower than those found in male populations with recent occupational exposure or high environmental exposure. Strong relationships were found between the concentrations of single mono- and di-ortho PCB congeners and groups of PCB congeners in serum. In our group of men PCB 153 was a good marker substance for the concentration of sigma PCB and sigma di-ortho PCB concentrations in serum. Moreover, among the mono-ortho PCB congeners analyzed, PCB 156 could be used as a marker for the sigma mono-ortho PCB TEQ concentrations in serum in the studied group. No useful marker substances were found among DDT compounds and other chlorinated pesticides and metabolites, except for trans-nonachlor which predicted the concentration of the metabolite oxychlordane fairly well.
authors.affiliation: Toxicology Division, The Swedish National Food Administration, and Department of Environmental Toxicology, Uppsala University. glwi@slv.se
authors.forename: A W
authors.initials: AW
authors.lastname: Glynn
authors.forename: A
authors.initials: A
authors.lastname: Wolk
authors.forename: M
authors.initials: M
authors.lastname: Aune
authors.forename: S
authors.initials: S
authors.lastname: Atuma
authors.forename: S
authors.initials: S
authors.lastname: Zettermark
authors.forename: M
authors.initials: M
authors.lastname: Maehle-Schmid
authors.forename: P O
authors.initials: PO
authors.lastname: Darnerud
authors.forename: W
authors.initials: W
authors.lastname: Becker
authors.forename: B
authors.initials: B
authors.lastname: Vessby
authors.forename: H O
authors.initials: HO
authors.lastname: Adami
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis*; D003362:Cost-Benefit Analysis; D004781:Environmental Exposure / Q000032:analysis*; D004785:Environmental Pollutants / Q000032:analysis*; D006801:Humans; D007306:Insecticides / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000097:blood*
chemical_list: D015415:Biomarkers; D004785:Environmental Pollutants; D007306:Insecticides; D011078:Polychlorinated Biphenyls