title: Industrial scale-up of countercurrent chromatography: predictive scale-up.
abstract: This study describes how scale-up in countercurrent chromatography (CCC) can be simply predicted on a process scale CCC device by running a preliminary analytical-sized sample and having knowledge of the stationary-phase retention at scale-up conditions. Results have shown that simple experimentation can lead within a day to a process with the capability of several kilograms per day (tons per year) compound yield, and that this is feasible with benchtop CCC units.
authors.affiliation: Brunel Institute for Bioengineering, Brunel University, Uxbridge, Middlesex, UK.
authors.forename: I A
authors.initials: IA
authors.lastname: Sutherland
authors.forename: L
authors.initials: L
authors.lastname: Brown
authors.forename: A S
authors.initials: AS
authors.lastname: Graham
authors.forename: G G
authors.initials: GG
authors.lastname: Guillon
authors.forename: D
authors.initials: D
authors.lastname: Hawes
authors.forename: L
authors.initials: L
authors.lastname: Janaway
authors.forename: R
authors.initials: R
authors.lastname: Whiteside
authors.forename: P
authors.initials: P
authors.lastname: Wood