title: Long-term pathological changes of expanded polytetrafluoroethylene (ePTFE) suture in the human heart.
abstract: Expanded PTFE (ePTFE) sutures have been used widely as a mitral chordal substitute. We present a structural analysis of ePTFE sutures implanted as artificial chordae for 7.5 years and 8.6 years in patients with mitral regurgitation. No calcification was found either macroscopically or microscopically, and the ePTFE suture retained its normal flexibility. The suture was totally encapsulated with host tissues composed of dense fibrous tissue covered with endothelial cells.
authors.affiliation: Department of Cardiovascular Surgery and Pathology, National Cardiovascular Center, Suita, Osaka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Minatoya
authors.forename: J
authors.initials: J
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Sasako
authors.forename: H
authors.initials: H
authors.lastname: Ishibashi-Ueda
authors.forename: C
authors.initials: C
authors.lastname: Yutani
authors.forename: S
authors.initials: S
authors.lastname: Kitamura
mesh_terms: D002815:Chordae Tendineae / Q000473:pathology / Q000601:surgery*; D004547:Elastic Tissue / Q000473:pathology; D004730:Endothelium, Vascular / Q000473:pathology; D005347:Fibroblasts / Q000473:pathology; D005487:Foam Cells / Q000473:pathology; D005549:Foreign-Body Reaction / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000473:pathology / Q000601:surgery*; D010210:Papillary Muscles / Q000473:pathology / Q000601:surgery; D011138:Polytetrafluoroethylene; D011183:Postoperative Complications / Q000473:pathology*; D013537:Sutures
chemical_list: D011138:Polytetrafluoroethylene