Synaptic structure and function in transgenic APP mice.
Efforts using transgenic mice are being made to understand the molecular and structural basis for dementia in Alzheimer's disease. Transgenic mice 12 to 18 months of age with amyloid plaques and impaired cognition show no neuronal or synaptic loss in the CA1 hippocampal subfield. Electrophysiological studies may yield new insights.
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K H
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Department of Neurology, University of Minnesota, Box 295 UMHC, 420 Delaware Street S.E., Minneapolis, Minnesota 55455, USA. hsiao005@tc.umn.edu
D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics* / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D051379:Mice; D008822:Mice, Transgenic; D013569:Synapses / Q000378:metabolism* / Q000473:pathology*
D016564:Amyloid beta-Protein Precursor