O-[2-hydroxy-3-(dialkylamino)propyl]ethers of (+)-1,7,7-trimethyl bicyclo[2.2.1]heptan-2-one oxime (camphor oxime) with analgesic and antiarrhythmic activities.
A novel series of O-[2-hydroxy-3-(dialkylamino)propyl]ethers of (+)-camphor oxime was prepared and tested for its cardiovascular, analgesic and anti-inflammatory properties. No significant anti-inflammatory and hypotensive activities were displayed by any of the compounds, whereas several of them are reasonably active as antiarrhythmic and analgesic agents.
Schenone
S
S
Dipartimento di Scienze Farmaceutiche dell'Università, Genoa, Italy. schensil@unige.it
Bruno
O
O
Ranise
A
A
Bondavalli
F
F
Filippelli
W
W
Falcone
G
G
Rinaldi
B
B
D000085:Acetates; D000157:Aconitine; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D009682:Magnetic Resonance Spectroscopy; D010091:Oximes / Q000138:chemical synthesis* / Q000494:pharmacology*; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000473:pathology
D000085:Acetates; D000700:Analgesics; D000889:Anti-Arrhythmia Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000959:Antihypertensive Agents; D001643:Bridged Bicyclo Compounds; D010091:Oximes; D000157:Aconitine