[Importance of adenosine A2A receptors in resistance to complete global cerebral ischemia].
Selective A2A agonists (CGS 21680 and DPMA) produce a moderate neuroprotector effect with respect to the complete global cerebral ischemia (GCI). At the same time, selective A2A antagonists 8-(3-chlorostyrylcaffeine (CSC) and ZM 241385 somewhat reduce the brain resistance to complete GCI, completely prevent the neuroprotector effect of CGS 21680, partly suppress the neuroprotector activity of adenosine and 5'-N-ethylcarboxamidoadenosine (NECA), and do not affect (CSC) or potentiate (ZM 241385) the neuroprotector effect of N6-cyclopentyladenosine. The A2A-receptors are probably mediating in the neuroprotector activity of CGS 21680 and participating in the natural brain stability with respect to complete GCI, as well as in the effects of NECA and adenosine.
Kulinskiĭ
V I
VI
Departments of Biochemistry and Pharmacology, Irkutsk Medical University, ul. Krasnogo Vosstaniya 1, Irkutsk, 664003 Russia.
Minakina
L N
LN
Usov
L A
LA
D000818:Animals; D002545:Brain Ischemia / Q000517:prevention & control*; D005260:Female; D008297:Male; D051379:Mice; D018696:Neuroprotective Agents / Q000494:pharmacology / Q000627:therapeutic use*; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D043705:Receptor, Adenosine A2A
D018696:Neuroprotective Agents; D058906:Purinergic P1 Receptor Agonists; D058915:Purinergic P1 Receptor Antagonists; D043705:Receptor, Adenosine A2A
Znachenie adenozinovykh A2A-retseptorov dlia ustoĭchivosti k polnoĭ global'noĭ ishemii golovnogo mozga.