title: Acute effect of physiologic hyperinsulinaemia on serum leptin concentration in healthy young people.
abstract: This study aimed to identify the acute effect of a physiologic dose of insulin, enough to produce hyperinsulinaemia similar to that obtained in the postprandial state, on serum leptin concentrations in healthy young people. A randomised, single blind controlled clinical trial was performed in 45 healthy, non-obese, young volunteers. Serum leptin concentration, uric acid, creatinine levels and lipid profile were determined for all subjects. Insulin suppression test modified with octreotide, used to produce physiologic hyperinsulinaemia, or saline infusion as control, were performed. Steady state insulin (SSI) concentrations were calculated and they represented the hyperinsulinaemia state. Clinical characteristics and laboratory profiles were similar between groups. There was no significant difference between the effect of insulin or saline infusions on the serum leptin concentration. The acute effect of physiologic hyperinsulinaemia did not modify the serum leptin concentration in healthy young people.
authors.affiliation: Medical Research Unit in Clinical Epidemiology, West National Medical Centre, Mexican Institute of Social Security, Guadalajara City.
authors.forename: M
authors.initials: M
authors.lastname: González-Ortiz
authors.forename: E
authors.initials: E
authors.lastname: Martínez-Abundis
authors.forename: J M
authors.initials: JM
authors.lastname: Mora-Martínez
mesh_terms: D000208:Acute Disease; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D003404:Creatinine / Q000097:blood; D005260:Female; D005947:Glucose; D006728:Hormones; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood* / Q000139:chemically induced; D007004:Hypoglycemic Agents; D007328:Insulin / Q000097:blood; D020738:Leptin / Q000097:blood*; D008055:Lipids / Q000097:blood; D008297:Male; D015282:Octreotide; D009994:Osmolar Concentration; D012016:Reference Values; D016037:Single-Blind Method; D014527:Uric Acid / Q000097:blood
chemical_list: D001786:Blood Glucose; D006728:Hormones; D007004:Hypoglycemic Agents; D007328:Insulin; D020738:Leptin; D008055:Lipids; D014527:Uric Acid; D003404:Creatinine; D005947:Glucose; D015282:Octreotide