Roles of postsynaptic density-95/synapse-associated protein 90 and its interacting proteins in the organization of synapses.
Synapses are central stages for neurotransmission. Neurotransmitters are released from the presynaptic membrane of one neuron, and bind to the receptors accumulated at the postsynaptic membrane, followed by the activation of the other neuron. The strength of a synapse is modified depending on the history of the previous neurotransmissions. This property is called synaptic plasticity and is implicated in learning and memory. Synapses contain not only the components essential for neurotransmission but also the signalling molecules involved in synaptic plasticity. The elucidation of the molecular structures of synapses is one of the key steps to understand the mechanism of learning and memory. Recent studies have revealed postsynaptic density (PSD)-95/synapse-associated protein (SAP) 90 as a core component in the architecture of synapses. In this review, we summarize up-to-date information about PSD-95/SAP90 and its interacting proteins, and the organization of synapses orchestrated
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Takai Biotimer Project, ERATO, Japan Science and Technology Corporation, Kobe.
Takai
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D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003599:Cytoskeleton / Q000378:metabolism; D007473:Ion Channels / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D008954:Models, Biological; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D000074407:SAP90-PSD95 Associated Proteins; D015398:Signal Transduction / Q000187:drug effects; D013569:Synapses / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*
D015815:Cell Adhesion Molecules; D007473:Ion Channels; D009419:Nerve Tissue Proteins; D011956:Receptors, Cell Surface; D000074407:SAP90-PSD95 Associated Proteins; D009569:Nitric Oxide; D011505:Protein-Tyrosine Kinases; D020928:Mitogen-Activated Protein Kinases