[Comparative characteristics of cerebrovascular protective effects of mildronate, riboxine, and their combination during modeling of cerebral hemodynamics disturbance].
Hydrogen clearance, polarographic, and electric impedance measurements on conscious rabbits with electrodes implanted into brain cortex, thalamus, and hypothalamus were used to study the state of hemodynamics, oxygen and water--electrolyte balance on a model of the zero-gravity-induced cerebrovascular disorders. The preliminary administration of mildronate (10 mg/kg, p.o.) reduced the hemodynamics disorder and optimized the oxygen balance more significantly than did riboxin (5 mg/kg). Both drugs markedly decreased the level of edematous phenomena in the brain. The antihypoxant and antiedematous effects of mildronate and riboxin increased upon their combined administration.
Beketov
A I
AI
Department of Pharmacology, Department of Clinical Immunology, Allergology, and Pharmacology, Simferopol State Medical University, Lenin bul. 5/7, Simferopol, Crimea, Ukraine.
Mametova
A N
AN
Polevik
I V
IV
Sapegin
I D
ID
D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000098:blood supply* / Q000378:metabolism; D001929:Brain Edema / Q000517:prevention & control; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D017097:Electric Impedance; D018475:Head-Down Tilt; D000860:Hypoxia / Q000517:prevention & control; D007290:Inosine Diphosphate / Q000494:pharmacology*; D008763:Methylhydrazines / Q000494:pharmacology*; D008833:Microcirculation; D010100:Oxygen / Q000502:physiology; D011048:Polarography; D011817:Rabbits; D014882:Water-Electrolyte Balance
D008763:Methylhydrazines; C050147:3-(2,2,2-trimethylhydrazine)propionate; D007290:Inosine Diphosphate; D010100:Oxygen
Sravnitel'naia kharakteristika tserebrovazoprotektornykh éffektov mildronata, riboksina i ikh kombinatsii pri modelirovanii narusheniĭ mozgovoĭ gemodinamiki.