Reversible posterior leukoencephalopathy after combination chemotherapy.
We describe a young woman with Burkitt's lymphoma, treated with intravenous adriamycine and cyclophosphamide and intrathecal cytarabine. She developed a reversible posterior leukoencephalopathy syndrome (RPLS) with typical MRI findings. Diffusion-weighted images during the first days after the onset of symptoms predicted a small irreversible lesion in the frontal lobe, verified on T2-weighted images 1 month later. The patient showed full recovery after high-dose steroid treatment.
Honkaniemi
J
J
Department of Neurology and Rehabilitation, University of Tampere, 33521 Tampere, Finland. bljaho@uta.fi
Kähärä
V
V
Dastidar
P
P
Latvala
M
M
Hietaharju
A
A
Salonen
T
T
Keskinen
L
L
Ollikainen
J
J
Vähämäki
L
L
Kellokumpu-Lehtinen
P
P
Frey
H
H
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D002051:Burkitt Lymphoma / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D007962:Leukocytes; D008279:Magnetic Resonance Imaging; D020258:Neurotoxicity Syndromes / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D013256:Steroids / Q000627:therapeutic use
D013256:Steroids; D003561:Cytarabine; D004317:Doxorubicin; D003520:Cyclophosphamide