title: Effect of superior cervical ganglionectomy on 24-h variations in hormone secretion from the anterior hypophysis and in hypothalamic monoamine turnover during the preclinical phase of Freund's adjuvant arthritis in rats.
abstract: The effect of superior cervical ganglionectomy (SCGx) on 24-h rhythms of circulating adrenocorticotropic hormone (ACTH), growth hormone (GH), prolactin and luteinizing hormone (LH) and of hypothalamic noradrenaline content and dopamine and serotonin turnover, was assessed in rats 3 days after administering Freund's complete adjuvant. In sham-operated rats, Freund's adjuvant injection increased serum ACTH without affecting its diurnal rhythmicity. SCGx, performed 10 days earlier, suppressed 24-h rhythmicity and augmented mean values of circulating ACTH. A depressive effect of immunization on GH release was found in both sham-operated and SCGx rats. GH concentrations did not exhibit diurnal rhythmicity and decreased after immunization. Time-of-day-related changes in serum prolactin were significant for all examined groups, except for SCGx-immunized rats. Freund's adjuvant administration augmented prolactin secretion. Daily changes in serum LH concentration and a decrease after immunization were found in both sham-operated and SCGx rats. SCGx: (i) counteracted inhibition of daily variations of noradrenaline content in medial hypothalamus of Freund's adjuvant-injected rats; (ii) decreased anterior hypothalamic dopamine turnover and augmented it in the medial hypothalamus; (iii) lowered amplitude of serotonin turnover rhythm in medial hypothalamus. The data indicate that several early changes in levels and 24-h rhythms of circulating ACTH and prolactin, and in hypothalamic noradrenaline content and dopamine and serotonin turnover, were modified by a previous SCGx in Freund's adjuvant-injected rats.
authors.affiliation: Departamento de Bioquímica y Biología Molecular III, Facultad de Medicina, Universidad Complutense, Madrid, Spain.
authors.forename: P O
authors.initials: PO
authors.lastname: Castrillón
authors.forename: D P
authors.initials: DP
authors.lastname: Cardinali
authors.forename: D
authors.initials: D
authors.lastname: Pazo
authors.forename: R A
authors.initials: RA
authors.lastname: Cutrera
authors.forename: A I
authors.initials: AI
authors.lastname: Esquifino
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000818:Animals; D001169:Arthritis, Experimental / Q000503:physiopathology*; D015306:Biogenic Monoamines / Q000378:metabolism*; D002940:Circadian Rhythm; D004298:Dopamine / Q000378:metabolism; D005620:Freund's Adjuvant / Q000008:administration & dosage; D015171:Ganglionectomy; D013006:Growth Hormone / Q000097:blood; D007031:Hypothalamus / Q000378:metabolism*; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D017783:Superior Cervical Ganglion / Q000502:physiology*
chemical_list: D015306:Biogenic Monoamines; D012701:Serotonin; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D013006:Growth Hormone; D005620:Freund's Adjuvant; D004298:Dopamine; D009638:Norepinephrine