title: Multiple carcinoids in the stomach with hypergastrinemia and type A gastritis: a case report.
abstract: We have experienced a case of the stomach with hypergastrinemia and type A gastritis with multiple carcinoids in a 37-year-old woman. An upper gastrointestinal series revealed multiple minute polyps in the upper body of the stomach. All polyps were diagnosed as carcinoid using endoscopic biopsies. She had neither symptom or signs of typical carcinoid disease. The serum gastrin level was as high as 725 pg/ml. Total gastrectomy was performed, and the diagnosis of multiple gastric carcinoids (sm, no) with type A gastritis was histologically confirmed. After the operation, the serum gastrin level returned to normal, and the patient has been doing well and is disease-free to date at 7 years after the operation. This case suggested that multiple gastric carcinoid lesions may be precipitated by chronic atrophic gastritis accompanying hypergastrinemia. In the treatment of multiple gastric carcinoids with type A gastritis, total gastrectomy with lymph node dissection should be standard operative procedure, in order to resect the fundic gland area completely which could be the origin of carcinoids and endocrine cell micronest.
authors.affiliation: Department of Surgery, Kurume University School of Medicine, Kurume 830-0011, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Aoyagi
authors.forename: K
authors.initials: K
authors.lastname: Koufuji
authors.forename: S
authors.initials: S
authors.lastname: Yano
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: Y
authors.initials: Y
authors.lastname: Terasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Yamasaki
authors.forename: J
authors.initials: J
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Shirouzu
mesh_terms: D000328:Adult; D002276:Carcinoid Tumor / Q000150:complications* / Q000473:pathology; D005260:Female; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000150:complications* / Q000473:pathology; D006801:Humans; D013274:Stomach Neoplasms / Q000150:complications* / Q000473:pathology
chemical_list: D005755:Gastrins