title: Correlated expression of adhesive properties for both white and red blood cells during inflammation.
abstract: The state of leukocyte and erythrocyte adhesiveness/aggregation was determined in the peripheral blood of 382 patients with infection/inflammation as well as in 72 controls by using a simple slide test and image analysis. A highly significant correlation (r = 0.4, n = 455, p < 0.001) was found between the state of leukocyte and erythrocyte adhesiveness/aggregation. The extent of both leukocyte and erythrocyte aggregation correlated with the concentration of fibrinogen. Significant aggregation of leukocytes with erythrocytes was noted as well. We conclude that both leukocyte and erythrocyte aggregation occur in the peripheral blood of patients with infection/inflammation. Such cell aggregation, which might have detrimental rheological consequences, can be detected by using our novel technique.
authors.affiliation: Department of Internal Medicine D, Tel Aviv Sourasky Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: O
authors.initials: O
authors.lastname: Rogowski
authors.forename: D
authors.initials: D
authors.lastname: Zeltser
authors.forename: R
authors.initials: R
authors.lastname: Rotstein
authors.forename: I
authors.initials: I
authors.lastname: Shapira
authors.forename: D
authors.initials: D
authors.lastname: Avitzour
authors.forename: R
authors.initials: R
authors.lastname: Fusman
authors.forename: T
authors.initials: T
authors.lastname: Mardi
authors.forename: V
authors.initials: V
authors.lastname: Prochorov
authors.forename: N
authors.initials: N
authors.lastname: Arber
authors.forename: S
authors.initials: S
authors.lastname: Berliner
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001424:Bacterial Infections / Q000097:blood; D002448:Cell Adhesion / Q000502:physiology; D002449:Cell Aggregation / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007249:Inflammation / Q000097:blood*; D007962:Leukocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D014777:Virus Diseases / Q000097:blood