title: [Reduction of perinatal transmission of HIV-1: antiretroviral prophylaxis and obstetrical interventions].
abstract: Incorporation of zidovudine prophylaxis (given to the mother during the third trimester of pregnancy and at delivery and to the newborn during the first 6 weeks of life) in clinical practice has substantially reduced the perinatal transmission of HIV-1 and the number of pediatric AIDS cases in industrialized countries. Rates of transmission of +/- 1% have been observed with the combination of antiretroviral prophylaxis and elective caesarean delivery. Elimination of perinatal transmission of HIV is therefore a feasible goal in Europe and the United States. Recent studies have identified less complex and less expensive preventive therapies more applicable to developing countries.
authors.affiliation: Services de Pédiatrie, C.H.U. Ambroise Paré, Mons.
authors.forename: P
authors.initials: P
authors.lastname: Lepage
authors.forename: M
authors.initials: M
authors.lastname: Hainaut
mesh_terms: D019380:Anti-HIV Agents / Q000627:therapeutic use; D002585:Cesarean Section; D019049:Developed Countries; D003906:Developing Countries; D005260:Female; D015658:HIV Infections / Q000517:prevention & control / Q000635:transmission*; D015497:HIV-1; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000517:prevention & control*; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D015215:Zidovudine / Q000627:therapeutic use
chemical_list: D019380:Anti-HIV Agents; D015215:Zidovudine
vernacular_title: Réduction de la transmission périnatale du VIH-1: prophylaxies antirétrovirales et interventions obstetricales.