title: Cytokine cross-talk between tubular epithelial cells and interstitial immunocompetent cells.
abstract: Immunostaining of renal biopsies of patients with interstitial rejection of allografts or other forms of interstitial inflammation has demonstrated the presence of activated T cells and monocytes/macrophages in the tubulointerstitial area. Cytokines that are produced by infiltrating cells are capable of activating tubular epithelial cells. In turn tubular epithelial cells can produce a wide variety of inflammatory mediators, including chemokines, which further regulate cellular influx. Interfering in this cross-talk between tubular epithelial cells and infiltrating cells might provide new options for therapeutic intervention.
authors.affiliation: Department of Nephrology, Leiden University Medical Center, The Netherlands. Kooten@lumc.nl
authors.forename: C
authors.initials: C
authors.lastname: van Kooten
authors.forename: M R
authors.initials: MR
authors.lastname: Daha
mesh_terms: D000818:Animals; D016207:Cytokines / Q000096:biosynthesis / Q000502:physiology*; D004847:Epithelial Cells / Q000502:physiology; D006801:Humans; D007121:Immunocompetence / Q000502:physiology*; D007684:Kidney Tubules / Q000166:cytology / Q000502:physiology*; D007962:Leukocytes / Q000502:physiology; D009393:Nephritis / Q000188:drug therapy / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D016207:Cytokines