title: Primary cutaneous T-cell-rich B-cell lymphoma: clinically distinct from its nodal counterpart?
abstract: The cases of two patients with Stage IE primary cutaneous T-cell-rich B-cell lymphoma (TCRBCL) are described. In both, the lesion showed a dense infiltrate by numerous small T lymphocytes with scattered histiocytes and large atypical B-lymphoid cells. Polymerase chain reaction assays demonstrated that the B cells were monoclonal, with immunoglobulin heavy-chain gene rearrangement. No clonal rearrangements of the T-cell receptor gamma gene were observed. Both patients were disease-free at 4 months and at 5 years after therapy, respectively. Although rare, primary cutaneous T-cell-rich B-cell lymphoma appears to have a better prognosis than its nodal counterpart, with or without skin involvement.
authors.affiliation: Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, Maryland 21287, USA.
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: C A
authors.initials: CA
authors.lastname: Griffin
authors.forename: R B
authors.initials: RB
authors.lastname: Mann
authors.forename: M J
authors.initials: MJ
authors.lastname: Borowitz
mesh_terms: D018951:Antigens, CD20 / Q000032:analysis; D017252:CD3 Complex / Q000032:analysis; D002999:Clone Cells; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics; D019675:Genes, T-Cell Receptor gamma / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology*; D016410:Lymphoma, T-Cell, Cutaneous / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012878:Skin Neoplasms / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology*
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex; D017931:DNA Primers; D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains