title: Lipid modulation and systemic inflammation.
abstract: N-6 and n-3 PUFAs from the diet are absorbed and reach the cell where they interact with fatty acid binding proteins within cell membranes and cytoplasm. They are processed in the endoplasmic reticulum (desaturation-elongation reactions, lipid synthesis, eicosanoid and epoxide production) and in peroxisomes (beta-oxidation, synthesis, oxidation products). They interact with receptors, ion channels, and nuclear elements; the result is modulation of gene expression. PUFA-induced alterations result in modulation of local and systemic inflammation and inflammatory disease activity.
authors.affiliation: Suburban Hospital, Bethesda, Maryland, USA.
authors.forename: G P
authors.initials: GP
authors.lastname: Zaloga
authors.forename: P
authors.initials: P
authors.lastname: Marik
mesh_terms: D004042:Dietary Fats, Unsaturated / Q000276:immunology* / Q000378:metabolism; D019587:Dietary Supplements; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D005395:Fish Oils; D006801:Humans; D007249:Inflammation / Q000378:metabolism*; D014280:Triglycerides / Q000235:genetics / Q000276:immunology / Q000378:metabolism
chemical_list: D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D014280:Triglycerides; C077446:Pikasol