[Introduction to genetic psychiatry: progress in uncovering genetic susceptibility to psychiatric disorders].
The recent progress in human genetics suggests major benefits in clinical practice, including psychiatry. This article introduces the research methodology used in psychiatric genetics and explains how it is applied, for a better understanding of the challenges facing psychiatric genetics and the strategies being used to overcome them. We will review the evidence of genetic factors in psychiatric disorder etiology as well as the specificity or non-specificity of their expression. We will discuss problems associated with the approximate nature of diagnostic methods, the incomplete penetrance and the genetic heterogeneity of psychiatric disorders, the presence of phenocopies and our uncertainty concerning the mode of inheritance of psychiatric disorders. Finally, we will provide an overview of the most promising results and set out priorities for future studies.
Roy
M A
MA
Département de psychiatrie de la Faculté de médecine de l'Université Laval et centre de recherche Université Laval Robert-Giffard.
Mérette
C
C
Maziade
M
M
D005819:Genetic Markers / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005838:Genotype; D006801:Humans; D001523:Mental Disorders / Q000235:genetics*; D010641:Phenotype; D011618:Psychotic Disorders / Q000235:genetics; D012559:Schizophrenia / Q000235:genetics
D005819:Genetic Markers
Introduction à la psychiatrie génétique: progrès vers la découverte des gènes de susceptibilité aux troubles psychiatriques.