title: Synthesis of some new phenylthiocarbamoyl 2-pyrazolin-5-ones of pharmaceutical interest.
abstract: Thiocarbamoylation reaction of 3-methyl-2-pyrazolin-5-one (1a) with two equivalents of PhNCS, resulted in the formation of 1,4-di(alpha-phenylthiocarbamoyl)-3-methylpyrazolone 3, which underwent cleavage of the thiocarbamoyl group at position 4 when coupled with aromatic diazonium salts affording 4-arylhydrazono-1-phenylthiocarbamoylpyrazolone (4a-j). Reactions of 4a with chloroacetyl chloride, benzenesulphonyl chloride, piperidine and hydrazine hydrate, resulted in the formation of 8.
authors.affiliation: Department of Chemistry, Faculty of Science, University of Mansoura, Mansoura, Egypt.
authors.forename: M A
authors.initials: MA
authors.lastname: Metwally
authors.forename: E
authors.initials: E
authors.lastname: Abdel-Latif
authors.forename: F A
authors.initials: FA
authors.lastname: Amer
mesh_terms: D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D011720:Pyrazoles / Q000138:chemical synthesis*; D013055:Spectrophotometry, Infrared
chemical_list: D007202:Indicators and Reagents; D011720:Pyrazoles