Rat small intestine muscle relaxation alkaloids from Orixa japonica leaves.
Two quinoline alkaloids, japonine (1) and eduline (2) were isolated from the methanol extract of the leaves of Orixa japonica as relaxants against rat small intestine muscle. The activity of these alkaloids was comparable to that of the typical muscle relaxant papaverine (4). This is also the first report of the isolation of eduline (2) from O. japonica.
Funayama
S
S
Department of Bioscience and Biotechnology, Aomori University, Japan. funayama@aomori-u.ac.jp
Tanaka
R
R
Kumekawa
Y
Y
Noshita
T
T
Mori
T
T
Kashiwagura
T
T
Murata
K
K
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D007583:Jejunum / Q000187:drug effects* / Q000502:physiology; D009126:Muscle Relaxation / Q000187:drug effects; D016716:PC12 Cells; D011804:Quinolines / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D019685:Rosales / Q000737:chemistry*; D013057:Spectrum Analysis
D000470:Alkaloids; D011804:Quinolines; C422365:eduline; C422366:japonine