title: Iron stores in multi-transfused thalassaemic patients seem not to be influenced by the HLA system.
abstract: The HLA-A and -B antigens of 99 Greek patients with transfusion dependent homozygous beta thalassaemia were determined. The HLA antigen distribution in thalassaemic patients with a severe transfusion siderosis and in patients without signs of siderosis were compared to that of 400 healthy unrelated controls from the same population. There is an increase of HLA-B 14 antigen in both groups of thalassaemics as compared with the controls. No significant difference exists in the distribution of all the other HLA antigens between the two sub-groups of thalassaemics or with the controls.
authors.affiliation: Thalassaemia Clinic, First Department of Medicine University of Athens, School of Medicine at Laikon Hospital, Greece. kkonstan@atlas.uoa.gr
authors.forename: K
authors.initials: K
authors.lastname: Konstantopoulos
authors.forename: S
authors.initials: S
authors.lastname: Theocharis
authors.forename: M
authors.initials: M
authors.lastname: Karagiorga
authors.forename: Y
authors.initials: Y
authors.lastname: Rombos
authors.forename: J
authors.initials: J
authors.lastname: Youssef
authors.forename: F
authors.initials: F
authors.lastname: Karabatsos
authors.forename: J
authors.initials: J
authors.lastname: Sourdis
mesh_terms: D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D017086:beta-Thalassemia / Q000097:blood* / Q000276:immunology* / Q000628:therapy
chemical_list: D006680:HLA Antigens; D007501:Iron