[Study of the correlation between in vitro and in vivo evaluation methods on biomaterials--DNA test and muscular implant test].
With the wide-spread use of biomaterials, the safety evaluation on biomaterials has become a very important step. This study on the correlation between DNA test and muscular implant test was done for finding out good in vitro evaluation method. The tissue toxicities of seven biomaterials were examined. Good correlation between DNA test and muscular implant test was demonstrated by Spearman sequential correlation analysis.
Wen
X
X
Shanghai Biomaterial Research & Test Center, Shanghai No. 9 Hospital, Shanghai Second Medical University, Shanghai 200023.
Zhang
C
C
Liu
X
X
Gu
G
G
D000818:Animals; D001672:Biocompatible Materials / Q000633:toxicity*; D002478:Cells, Cultured; D004247:DNA / Q000032:analysis; D008422:Materials Testing / Q000379:methods*; D009132:Muscles / Q000601:surgery; D019736:Prostheses and Implants / Q000592:standards; D011817:Rabbits
D001672:Biocompatible Materials; D004247:DNA