title: Progress in hereditary tauopathies: a mutation in the Tau gene (G389R) causes a Pick disease-like syndrome.
abstract: We describe the clinical and pathologic phenotypes of the G389R mutation in exon 13 of the Tau gene. Progressive aphasia and memory disturbance are the initial signs and begin in the fourth or fifth decade of life, followed by apathy, indifference, hyperphagia, rigidity, pyramidal signs and dementia. Death occurs after two to five years. Magnetic resonance imaging and neuropathologic studies show frontal and temporal atrophy. Pick body-like and axonal filamentous inclusions found in the neocortex and subcortical white matter, respectively, are tau immunoreactive. Immunoblot analysis of sarkosyl-insoluble tau shows two major bands of 60 and 64 kDa that, upon dephosphorylation, resolve into four bands of three- and four-repeat isoforms. Isolated tau filaments are often straight and occasionally twisted. Recombinant mutant tau protein shows a reduced ability to promote microtubule assembly, suggesting that this may be the primary effect of the mutation. The present findings indicate that the G389R mutation in Tau can cause a dementia similar to that in Pick's disease.
authors.affiliation: Department of Pathology and Laboratory Medicine, Division of Neuropathology, Indiana University School of Medicine, 635 Barnhill Drive, MS A142, Indianapolis, IN 46202, USA. bghetti@iupui.edu
authors.forename: B
authors.initials: B
authors.lastname: Ghetti
authors.forename: J R
authors.initials: JR
authors.lastname: Murrell
authors.forename: P
authors.initials: P
authors.lastname: Zolo
authors.forename: M G
authors.initials: MG
authors.lastname: Spillantini
authors.forename: M
authors.initials: M
authors.lastname: Goedert
mesh_terms: D000328:Adult; D019943:Amino Acid Substitution; D001284:Atrophy; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D003704:Dementia / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D007558:Italy; D020125:Mutation, Missense; D010641:Phenotype; D020774:Pick Disease of the Brain / Q000235:genetics* / Q000473:pathology / Q000523:psychology; D013577:Syndrome; D013702:Temporal Lobe / Q000473:pathology; D016875:tau Proteins / Q000235:genetics*
chemical_list: D016875:tau Proteins