title: Corneal sensitivity and some properties of the tear film after laser in situ keratomileusis.
abstract: OBJECTIVE
  To investigate central corneal sensitivity, lipid layer structure of the precorneal tear film, and tear volume after laser in situ keratomileusis (LASIK).
  
  
  METHODS
  Central corneal sensitivity was measured using the Non-Contact Corneal Aesthesiometer. The aesthesiometer was mounted on a slit lamp and an airpulse of controlled pressure was directed onto the cornea. When central corneal sensitivity was reduced, a higher air pulse pressure was required to stimulate the cornea. The final central corneal sensitivity threshold measured was recorded in millibars. Tear lipid layer structure was assessed by optical interferometry and classified according to appearance using the Keeler Tearscope. Tear volume was measured using the phenol red cotton thread test. Subjects were recruited from a group of patients after LASIK who had experienced no complications (n=22). The average postoperative time was 14 weeks and measurements were taken on one eye. In bilateral cases, measurements were recorded from the right eye only. Average attempted correction was -6.30 D (range, -2 to -11 D). Age-matched controls were later recruited for central corneal sensitivity threshold (n=24). A second group of age-matched controls were recruited for tear volume and lipid layer structure (n=24).
  
  
  RESULTS
  The median (range) was 1.1 mbars (0.2 to 4.3 mbars) after LASIK and 0.58 mbars (0.20 to 1.3 mbars) in the controls; the difference was statistically significant (P = .043). The lipid layer of the tear film tended to be thinner in eyes after LASIK compared with controls (P = .032). The mean (+/- SD) tear volume was 16.9 +/- 8.3 mm after LASIK and 19.8 +/- 7.1 mm in controls. This difference was not statistically significant (P = .492).
  
  
  CONCLUSIONS
  At 14 weeks postoperatively, central corneal sensitivity was below normal levels and the tear lipid layer was thinner. The poorer quality lipid layer may predispose to symptoms of dry eye after LASIK.
authors.affiliation: Refractive Surgery Section, Alicante Institute of Ophthalmology, University Miguel Hernandez of Elche, Spain. Dr_SPatel@cs.com
authors.forename: S
authors.initials: S
authors.lastname: Patel
authors.forename: J J
authors.initials: JJ
authors.lastname: Pérez-Santonja
authors.forename: J L
authors.initials: JL
authors.lastname: Alió
authors.forename: P J
authors.initials: PJ
authors.lastname: Murphy
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003315:Cornea / Q000502:physiology*; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D009216:Myopia / Q000378:metabolism / Q000601:surgery*; D012677:Sensation / Q000502:physiology*; D013666:Tears / Q000378:metabolism*