title: Short-term results after aortic valve replacement with stentless xenografts in elderly patients.
abstract: OBJECTIVE
  Our aim was to chart the short-term results of the first 75 of our patients who had undergone first-time aortic valve replacement (AVR) with stentless xenografts.
  
  
  METHODS
  Our study included a complete follow-up (mean/max. 1.5/3.7 years) of the first 75 patients (42 males, 33 females; mean age 74, range 61-84 years) who underwent a first AVR with stentless xenografts.
  
  
  RESULTS
  Forty-three percent of patients were in functional class II and 57% in classes III-IV preoperatively. Coronary artery bypass grafting (CABG) was performed in 33 patients. Early mortality (< or = 30 days) was 6.7%, with no significant relation to CABG or age. Crude survival was 81% (95% confidence interval, CI: 71-91 %) at 3 years. Using a multivariate analysis, we identified a low left ventricular ejection fraction as a predictor of early and late mortality. Late survival (early mortality excluded) was comparable with the survival of a matched Danish background population. There were six embolic events (all cerebral: 3 minor, 1 major, 2 fatal), while two patients underwent redo-AVR because of either endocarditis (fatal) or aortic regurgitation caused by malaligned commissures. There were no other valve-related complications. Cumulative freedom was 89% (95% CI: 79-99%) for embolism and 86% (95% CI: 76-96 %) for all complications at 3 years. At the end of the study, 64% of the survivors were in functional class I, 34% were in class II and 2% in class III.
  
  
  CONCLUSIONS
  Considering the age composition of our patients, and compared with international results, our early mortality rates were acceptable. The absence of late excess mortality compared with the background population and the functional status at end-of-study may indicate the potential haemodynamic advantages of stentless aortic valves, at least in the short term.
authors.affiliation: Department of Cardio-Thoracic Surgery, Copenhagen University Hospital, Gentofte, Denmark.
authors.forename: S S
authors.initials: SS
authors.lastname: Larsen
authors.forename: O
authors.initials: O
authors.lastname: Lund
authors.forename: H
authors.initials: H
authors.lastname: Hemmert-Lund
authors.forename: M
authors.initials: M
authors.lastname: Bundgaard
authors.forename: S
authors.initials: S
authors.lastname: Ali
authors.forename: S
authors.initials: S
authors.lastname: Aggestrup
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve; D005260:Female; D006349:Heart Valve Diseases / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D016019:Survival Analysis; D016896:Treatment Outcome