Transformations of 12,13-epoxy-11-hydroxy-9-octadecenoic acid and 4,5-epoxy-N-acetylsphingosine by incubation with liver homogenate and liver microsomes.
Transformation of 12,13-epoxy-11-hydroxy-9-octadecenoic acid and 4,5-epoxy-N-acetylsphingosine by addition of porcine liver homogenate and human liver microsomes, respectively was investigated. Both epoxides were converted to corresponding dioles by porcine liver homogenate, but not by human liver microsomes, suggesting location of the hydrolyzing enzymes not in the microsomes, but within the cell wall.
Möllenberg
A
A
Institut für Organische Chemie I, Universität Bayreuth, Germany.
Spiteller
G
G
D000818:Animals; D001711:Biotransformation; D002462:Cell Membrane / Q000378:metabolism; D002518:Ceramides / Q000493:pharmacokinetics*; D004852:Epoxy Compounds / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D009829:Oleic Acids / Q000493:pharmacokinetics*; D010084:Oxidation-Reduction; D013045:Species Specificity; D013552:Swine
C421176:12,13-epoxy-11-hydroxy-9-octadecenoic acid; C421177:4,5-epoxy-N-acetylsphingosine; D002518:Ceramides; D004852:Epoxy Compounds; D009829:Oleic Acids