Serum levels of vascular cell adhesion molecule 1 in the early post-treatment defervescent phase of falciparum malaria.
Elevated plasma or serum levels of vascular cell adhesion molecule 1 (VCAM-1) have been reported in the febrile phase of falciparum malaria. However, little is known about serum VCAM-1 levels in the early post-treatment defervescent phase. Serum VCAM-1, tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), and creatinine levels were determined in six Japanese patients with uncomplicated falciparum malaria during the acute febrile phase and the early post-treatment defervescent phase. The serum VCAM-1 values recorded for patients during the early post-treatment defervescent phase were significantly lower than those noted during the febrile phase (P < 0.05), but no significant difference in serum creatinine values was identified. TNF-alpha and IL-1beta levels were below the limit of detection in the serum of all patients during both the febrile phase and the early post-treatment defervescent phase. The serum levels of VCAM-1 were not related to parasitemia.
Ohnishi
K
K
Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Sumida City, Japan.
Kimura
K
K
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D018512:Parasitemia / Q000276:immunology* / Q000469:parasitology; D010963:Plasmodium falciparum / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D000962:Antimalarials; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1