Intermediate syndrome secondary to ingestion of chlorpiriphos.
A rural-area resident male patient deliberately ingested chlorpiriphos, an organophosphate insecticide. Although presented with cholinergic symptoms initially, he suffered general condition deterioration after 4 d characterized by muscular weakness, hypotonia, arreflexia and recumbent dyspnea requiring ventilatory support. These clinical manifestations occur from liposoluble organophosphates or metabolites with long-lasting half time, causeing delayed inhibition of acetylcholinesterase and subsequent burn out of the neuromuscular junction from acetylcholine overstimulation.
Guadarrama-Naveda
M
M
Department of Pharmacology and Toxicology, Universidad de Los Andes, ULA, School of Medicine, Mérida, Venezuela.
de Cabrera
L C
LC
Matos-Bastidas
S
S
D000328:Adult; D002606:Charcoal / Q000627:therapeutic use; D004390:Chlorpyrifos / Q000506:poisoning*; D002802:Cholinesterases / Q000097:blood; D006801:Humans; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D009123:Muscle Hypotonia / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D013406:Suicide, Attempted; D016896:Treatment Outcome
D007306:Insecticides; D002606:Charcoal; D002802:Cholinesterases; D004390:Chlorpyrifos