Comparative immunohistochemical study of insulin-like growth factor II and insulin-like growth factor receptor type 1 in pediatric brain tumors.
Insulin-like growth factor (IGF)-II is an important growth factor in development of the central nervous system. The purpose of this study was to evaluate expression of IGF-II and IGF receptor type 1 (IGFR1) in various pediatric brain tumors. Immunohistochemistry for IGF-II and IGFR1 was performed on 15 choroid plexus papillomas (CPPs) including 1 atypical CPP, 2 choroid plexus carcinomas (CPCs), 5 anaplastic ependymomas, 7 nonanaplastic ependymomas (simply referred to as "ependymoma"), 5 medulloblastomas, 1 cerebral neuroblastoma, and 1 atypical teratoid/rhabdoid tumor (ATRT) along with 10 non-neoplastic choroid plexus and 3 non-neoplastic ependymal linings. All non-neoplastic choroid plexus, CPPs, CPCs, anaplastic ependymomas, ATRT, 71% of ependymomas, and 67% of non-neoplastic ependymal linings showed cytoplasmic positivity for IGF-II, whereas all medulloblastomas and the cerebral neuroblastoma were negative for IGF-II. In addition to cytoplasmic positivity for IGFR1, membranous positivity was observed in 73% of CPPs, both CPCs, the ATRT, 22% of non-neoplastic choroid plexus, 80% of anaplastic ependymomas, and 29% of ependymomas, but not in any medulloblastoma, cerebral neuroblastoma, or non-neoplastic ependymal lining. IGF-II and IGFR1 may play roles in the pathogeneses of CPP, CPC, anaplastic ependymoma, ependymoma, and ATRT. Immunohistochemical testing for IGF-II and IGFR1 may be useful in differentiating ATRT, CPC, and anaplastic ependymoma from medulloblastoma and cerebral neuroblastoma.
Ogino
S
S
Department of Pathology, University Hospitals of Cleveland and Case Western Reserve University, OH 44106, USA.
Kubo
S
S
Abdul-Karim
F W
FW
Cohen
M L
ML
D000293:Adolescent; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology; D002540:Cerebral Cortex / Q000033:anatomy & histology / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D002831:Choroid Plexus / Q000033:anatomy & histology / Q000378:metabolism; D016545:Choroid Plexus Neoplasms / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D004806:Ependymoma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008527:Medulloblastoma / Q000378:metabolism / Q000473:pathology; D010212:Papilloma / Q000378:metabolism / Q000473:pathology; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D018335:Rhabdoid Tumor / Q000473:pathology; D013687:Telencephalon / Q000473:pathology; D013724:Teratoma / Q000378:metabolism / Q000473:pathology
D007335:Insulin-Like Growth Factor II; D017526:Receptor, IGF Type 1