Electron transfer vs. proton transfer within radical-cation clusters of guanosine and deoxyguanosine with substituted naphthalenes and sinapinic acid.
Guanosine (G) and deoxyguanosine (dG) radical cations can be generated in the gas phase by single electron transfer (SET) within nucleoside-dimethoxynaphthalenes (1-2) electron-bound heterodimers produced by fast atom bombardment in a four sector mass spectrometer. The nucleobase guanine is much more easily oxidized when it is linked to a ribose moiety. The radical cation dimers formed by G and dG with sinapinic acid behave as proton-bound heterodimers. The experiments mimic to some extent the migration of radical sites within stacking bases which causes DNA damaging through depurination processes.
Liguori
A
A
Dipartimento di Chimica, Università della Calabria, Arcavacata di Rende, CS, Italy.
Napoli
A
A
Sindona
G
G
D002412:Cations; D003373:Coumaric Acids / Q000737:chemistry* / Q000528:radiation effects; D003849:Deoxyguanosine / Q000737:chemistry*; D004579:Electron Transport; D006151:Guanosine / Q000737:chemistry*; D006859:Hydrogen / Q000737:chemistry; D009281:Naphthalenes / Q000737:chemistry* / Q000528:radiation effects; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014466:Ultraviolet Rays
D002412:Cations; D003373:Coumaric Acids; D009281:Naphthalenes; D006151:Guanosine; C073734:sinapinic acid; D006859:Hydrogen; D003849:Deoxyguanosine