title: FR191512, a novel anti-influenza agent isolated from a fungus strain No.17415. II. Biological properties.
abstract: FR191512, a novel polyphenolic compound, inhibited the infectivity of influenza A virus in Madin-Darby canine kidney (MDCK) cells in vitro. Furthermore, FR191512 showed good in vivo anti-influenza activity in a mouse model of intranasal infection with influenza A virus. The cytotoxic activity of FR191512 against MDCK cells was very weak.
authors.affiliation: Fermentation Development Laboratories, Fujisawa Pharmaceutical Co, Ltd, Nishikasugai-gun, Aichi, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nishihara
authors.forename: E
authors.initials: E
authors.lastname: Tsujii
authors.forename: Y
authors.initials: Y
authors.lastname: Yamagishi
authors.forename: T
authors.initials: T
authors.lastname: Kino
authors.forename: M
authors.initials: M
authors.lastname: Hino
authors.forename: M
authors.initials: M
authors.lastname: Yamashita
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D004195:Disease Models, Animal; D004285:Dogs; D005658:Fungi / Q000737:chemistry*; D009980:Influenza A virus / Q000187:drug effects*; D051379:Mice; D008826:Microbial Sensitivity Tests; D011091:Polyesters / Q000302:isolation & purification* / Q000494:pharmacology; D012118:Resorcinols / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D000998:Antiviral Agents; C421166:FR 191512; D011091:Polyesters; D012118:Resorcinols