New constituents and antiplatelet aggregation and anti-HIV principles of Artemisia capillaris.
Five new constituents including a flavonoid, artemisidin A (1), and four coumarins, artemicapins A (2), B (3), C (4) and D (5), together with 70 known compounds (6-75), have been isolated and characterized from the aerial part of Artemisia capillaris. The structures of these compounds were determined from spectral analyses and/or chemical evidence. Among them, 15 compounds (3, 6, 10, 18. 30-32, 38-41, 44, 45, 51, and 55) showed antiplatelet aggregation activity and three compounds (10, 17, and 51) demonstrated significant activity against HIV replication in H9 lymphocytic cells.
Wu
T S
TS
Department of Chemistry, National Cheng Kung University, Tainan, Taiwan, Republic of China. tswu@mail.ncku.edu.tw
Tsang
Z J
ZJ
Wu
P L
PL
Lin
F W
FW
Li
C Y
CY
Teng
C M
CM
Lee
K H
KH
D000114:Acetylene / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D019380:Anti-HIV Agents / Q000302:isolation & purification*; D019306:Artemisia / Q000737:chemistry*; D001792:Blood Platelets / Q000187:drug effects; D002109:Caffeic Acids / Q000494:pharmacology; D003374:Coumarins / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013053:Spectrophotometry
D019380:Anti-HIV Agents; D002109:Caffeic Acids; D003374:Coumarins; D010975:Platelet Aggregation Inhibitors; C044736:phenylacetylene; D000114:Acetylene; C040048:caffeic acid