Parkinsonian symptoms as an initial manifestation in a Japanese patient with acquired immunodeficiency syndrome and Toxoplasma infection.
We studied a Japanese patient who developed parkinsonian symptoms over 3 months before the diagnosis of acquired immunodeficiency syndrome. Brain MRI showed multiple lesions with mass effect and ring enhancement in the basal ganglia and subcortical white matter suggesting Toxoplasma infection. Anti-Toxoplasma therapy and highly active antiretroviral therapy for 6 months allowed improvement of parkinsonism, brain MRI findings, and immune system.
Murakami
T
T
Department of Neurology, Kumamoto University School of Medicine.
Nakajima
M
M
Nakamura
T
T
Hara
A
A
Uyama
E
E
Mita
S
S
Matsushita
S
S
Uchino
M
M
D017088:AIDS-Related Opportunistic Infections / Q000150:complications* / Q000188:drug therapy; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active; D002230:Carbidopa / Q000627:therapeutic use; D003342:Corpus Striatum / Q000469:parasitology / Q000473:pathology; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010296:Parietal Lobe / Q000469:parasitology / Q000473:pathology; D020734:Parkinsonian Disorders / Q000188:drug therapy / Q000209:etiology* / Q000469:parasitology; D011739:Pyrimethamine / Q000627:therapeutic use; D013587:Syphilis / Q000150:complications; D016781:Toxoplasmosis, Cerebral / Q000150:complications* / Q000188:drug therapy
D000981:Antiprotozoal Agents; D007980:Levodopa; D002230:Carbidopa; D011739:Pyrimethamine