title: Regeneration of the junctional epithelium and connective tissue after transplantation of detergent-processed allo-teeth.
abstract: The authors have developed a new artificial dental implant and evaluated it in a dog model in terms of its potential to produce: I) regeneration of junctional epithelium; II) regeneration and attachment of connective tissue. The implants were constructed from allo-teeth. We removed the cell components from the periodontal ligaments of these teeth with a detergent (1% TritonX-100); the remaining acellular periodontal ligament acted as an extracellular matrix upon which regeneration and attachment could proceed. We placed 10 of these implants in the just-extracted sites of three beagle dogs. We observed regeneration of both junctional epithelium and connective tissue at all implant sites after 3 months. The connective tissue was attached in all cases. Use of the acellular periodontal ligament as an extracellular matrix may facilitate regeneration of host periodontal ligament tissue, thus contributing to recovery of host immunological defense and long-term oral function.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Faculty of Medicine, Kyoto University, Japan. inouem@frontier.kyoto-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Shigeno
authors.forename: H
authors.initials: H
authors.lastname: Ueda
authors.forename: N
authors.initials: N
authors.lastname: Tamura
authors.forename: S
authors.initials: S
authors.lastname: Fukuda
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: T
authors.initials: T
authors.lastname: Nakahara
authors.forename: T
authors.initials: T
authors.lastname: Toba
authors.forename: M
authors.initials: M
authors.lastname: Yoshitani
authors.forename: T
authors.initials: T
authors.lastname: Iizuka
authors.forename: Y
authors.initials: Y
authors.lastname: Shimizu
mesh_terms: D000818:Animals; D003757:Dental Implantation / Q000379:methods; D015921:Dental Implants; D004285:Dogs; D004846:Epithelial Attachment / Q000254:growth & development*; D005109:Extracellular Matrix / Q000378:metabolism*
chemical_list: D015921:Dental Implants