[Decreased growth hormone secreting cells of the hypophysis in senile cachexia].
Basic morphometry of the pituitary gland in aged patients with cachexia was performed. In 10 control specimens, growth hormone(GH) cells accounted for 42.9 +/- 3.4% of the total, compared with 33.8 +/- 7.0%(p < or = 0.01) in patients with severe cachexia senilis. ACTH cells accounted for 16.0 +/- 7.4% in the control group and 14.1 +/- 9.0% in the senile cachexia group(p > or = 0.1). The mean pituitary weight was 0.60 g in control cases and 0.46 g in cases of extreme cachexia(p < or = 0.01). In the hypophyses of patients with senile cachexia, atrophy of GH cells and increase of the fibrous stroma were also prominent. The ratio of the summarized value for total GH cells in cachexia senilis patients and controls was 1:2.2. The difference was regarded as sufficiently large to be a causative factor in the establishment of cachexia senilis.
Takanashi
R
R
Division of Pathology, Central Clinical Laboratories, Mitsui Memorial Hospital, Chiyoda-ku, Tokyo 101-0024.
Sugawara
O
O
Mernyei
M
M
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000473:pathology*; D001284:Atrophy; D002100:Cachexia / Q000473:pathology*; D002452:Cell Count; D005260:Female; D019382:Human Growth Hormone / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D010902:Pituitary Gland / Q000166:cytology* / Q000378:metabolism / Q000473:pathology
D019382:Human Growth Hormone; D000324:Adrenocorticotropic Hormone