Acute effects of zopiclone on blood glucose level and serum lipids in hyperlipidemic rats.
In rats rendered hyperlipidemic by ip administration of Triton WR-1339, the ip administration of zopiclone at doses of 1.25, 2.5, 5.0, 7.5, 10.0 and 15.0 mg/kg, a cyclopyrrolone acting upon the central benzodiazepine receptors, induces very significant reductions of total lipids, total cholesterol, and triglycerides, at nearly all of the doses. The most active dose was 5.0 mg/kg. The blood glucose level was diminished by doses of 1.25, 2.5, 7.5 and 15.0 mg/kg and it was not changed by the rest of the other doses.
Cuparencu
B
B
Department of Pharmacology, Faculty of Medicine and Pharmacy, University of Oradea, Cluj-Napoca, Romania.
Horák
J
J
Horák
A
A
Tiglea
M
M
D000818:Animals; D053961:Azabicyclo Compounds; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006949:Hyperlipidemias / Q000097:blood* / Q000139:chemically induced; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008055:Lipids / Q000097:blood*; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D053961:Azabicyclo Compounds; D001786:Blood Glucose; D006993:Hypnotics and Sedatives; D008055:Lipids; D010879:Piperazines; D014280:Triglycerides; C515050:zopiclone; D002784:Cholesterol