Nutritional abnormalities and supplementation in chronic obstructive pulmonary disease.
Weight loss and muscle wasting commonly occur in patients with chronic obstructive pulmonary disease (COPD). A decreased dietary intake and elevated energy requirements underlie weight loss in these patients. Disturbances in intermediary metabolism caused by altered anabolic and catabolic mediators such as hormones, cytokines, and growth factors, and resulting in disproportionate muscle wasting have been described. Nutritional supplementation in combination with an anabolic stimulus (e.g. exercise) has been shown effective in improving functional capacity, health status, and mortality in most depleted patients. Nutritional or pharmacologic modulation of the catabolic response may further enhance the response in the near future.
Schols
A M
AM
Department of Pulmonology, University Hospital Maastricht, Maastricht, Netherlands. a.schols@pul.unimaas.nl
Wouters
E F
EF
D000465:Algorithms; D045930:Anabolic Agents / Q000627:therapeutic use; D019587:Dietary Supplements; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications* / Q000178:diet therapy / Q000378:metabolism / Q000503:physiopathology; D009748:Nutrition Disorders / Q000178:diet therapy / Q000209:etiology*; D010349:Patient Compliance; D011788:Quality of Life; D015431:Weight Loss / Q000502:physiology
D045930:Anabolic Agents