Comparable implantation rates with fresh vs frozen embryo transfer suggests that controlled ovarian hyperstimulation has an adverse effect on conception outcome.
OBJECTIVE
A retrospective comparison of fresh vs frozen embryo pregnancy rates.


METHODS
All frozen embryos transferred used in the analysis including deselected embryos from the oocyte retrieval cycle, and twice-frozen embryos.


RESULTS
Pregnancy and implantation rates following fresh or frozen embryo transfers were similar.


CONCLUSIONS
The similar outcomes despite the obvious disadvantages for the frozen-thawed embryo suggests that some other factor reduces the chance of embryo implantation on oocyte-retrieval cycles. An adverse affect of controlled ovarian hyperstimulation on the uterine environment is a strong possibility.
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J H
JH
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, USA.
Katsoff
D
D
Brittingham
D
D
Summers-Chase
D
D
Wilson
C
C
D000328:Adult; D000375:Aging; D015925:Cryopreservation; D010064:Embryo Implantation; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D010062:Ovulation Induction / Q000009:adverse effects*; D011247:Pregnancy; D012189:Retrospective Studies