Intestinal cell adhesion molecules. Liver-intestine cadherin.
The cadherin superfamily comprises a large number of cell adhesion molecules, several of which are expressed in the gastrointestinal tract. LI-cadherin represents a novel type of cadherin within the cadherin superfamily distinguished from other cadherins by structural and functional features described in this review. In the mouse and human, LI-cadherin is selectively expressed on the basolateral surface of enterocytes and goblet cells in the small and large intestine, whereas in the rat this cadherin is additionally detectable in hepatocytes. LI-cadherin is capable of mediating Ca(2+)-dependent homophilic cell-cell adhesion independent of interactions with the cytoskeleton, indicating that the adhesive function of this novel cadherin is complementary to that of E-cadherin and desmosomal cadherins co expressed in the intestinal mucosa.
Gessner
R
R
Institut für Laboratoriumsmedizin und Pathobiochemie, Charité, Campus Virchow-Klinikum, Augustenburger Platz 1, 13353 Berlin, Germany.
Tauber
R
R
D015820:Cadherins / Q000235:genetics* / Q000378:metabolism*; D020895:Enterocytes / Q000737:chemistry / Q000378:metabolism; D020397:Goblet Cells / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000737:chemistry* / Q000166:cytology / Q000378:metabolism*; D008099:Liver / Q000737:chemistry* / Q000378:metabolism*; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D015820:Cadherins