title: [Proton magnetic resonance spectroscopy in diagnostics of tumorous and nontumorous lesions in brain].
abstract: Whether proton magnetic resonance spectroscopy (1H-MRS) can be used in the diagnosis of tumorous and nontumorous lesions of the brain was studied. The results of studies were analyzed in 80 patients, including 54 patients with brain tumors (astrocytomas and meningiomas), 20 with nontumorous lesions of the brain, and 6 apparently healthy individuals (controls). The nontumorous lesions of the brain involved cerebral circulatory disorders as ischemia (n = 14) and postradiation changes (n = 6). The studies were performed on a 1.5-T Signa-Horizont magnetic resonance tomograph by using the PROBE/SV programme package. The peak ratios of the following metabolites: N-acetylaspartate (NAA), choline (Cho), creatine, lactate (Lac), lipids (Lip) were examined in the spectra obtained. The spectra of astrocytomas showed a reduced peak of NAA, an elevated peak Cho; there was an increase in the peak of Lac along with higher tumor malignancy stage. The spectra of meningiomas presented a high peak of Cho along with a noticeable reduction in the peaks of other metabolites, the peak of NAA was not visualized. In ischemic lesion of the brain, the peak of Lac appeared within the first hours when the peaks of other metabolites were unchanged. A rise in the peak of Lac and a reduction in that of other metabolites were detectable with time. In radiation-induced lesions, the spectrum displayed a high peak of Lac and the peak of Lip appeared with virtually complete reduction in the peaks of other metabolites. 1H-MRS should be considered as an axillary technique used in combination with routine MRI in the diagnosis of various lesions of the brain, which can estimate chemical compositions, time-course of metabolic changes in the study tissue.
authors.forename: A E
authors.initials: AE
authors.lastname: Podoprigora
authors.forename: I N
authors.initials: IN
authors.lastname: Pronin
authors.forename: L M
authors.initials: LM
authors.lastname: Fadeeva
mesh_terms: D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D011522:Protons; D011839:Radiation, Ionizing
chemical_list: D011522:Protons
vernacular_title: Protonnaia magnitno-rezonansnaia spektroskopiia v diagnostike opukholevykh i neopukholevykh porazheniĭ golovnogo mozga.