title: Iontophoresis treatment of basal cell carcinoma with cisplatin: a case report.
abstract: Iontophoresis is a process that uses electrical current to increase the flux of ionized substances through tissue. Iontophoresis has been used in rehabilitation to decrease inflammation and pain using dexamethasone and lidocaine. In 1993, Chang et al. reported visual improvements in the lesions of nine patients diagnosed with basal cell carcinoma (BCC) following iontophoresis of cisplatin. The present case report describes the successful treatment of a 67-year-old male with a histologically confirmed BCC on his upper anterolateral left leg. The treatment consisted of four cycles of five successive days of cisplatin iontophoresis, with a 2-week rest period between cycles. The cisplatin solution (5 mL at 1 mg/mL) was used in combination with epinephrine hydrochloride. The effectiveness of the treatment was confirmed by post-treatment biopsies, which revealed granulation tissue scarring without evidence of BCC. Measurements of cellular proliferation were monitored immunohistochemically with Ki-67 and cell cycle distribution analyzed by flow cytometry.
authors.affiliation: Department of Rehabilitation Sciences, College of Health Professions, Medical University of South Carolina, Charleston 29425, USA.
authors.forename: T R
authors.initials: TR
authors.lastname: Bacro
authors.forename: E B
authors.initials: EB
authors.lastname: Holladay
authors.forename: M J
authors.initials: MJ
authors.lastname: Stith
authors.forename: J C
authors.initials: JC
authors.lastname: Maize
authors.forename: C M
authors.initials: CM
authors.lastname: Smith
mesh_terms: D000368:Aged; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage* / Q000627:therapeutic use; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology; D002453:Cell Cycle; D002945:Cisplatin / Q000008:administration & dosage* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D004341:Drug Evaluation; D004837:Epinephrine / Q000008:administration & dosage; D005434:Flow Cytometry; D006801:Humans; D007478:Iontophoresis; D019394:Ki-67 Antigen / Q000032:analysis; D007866:Leg; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000188:drug therapy* / Q000473:pathology
chemical_list: D018906:Antineoplastic Agents, Alkylating; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D002945:Cisplatin; D004837:Epinephrine