title: Synthesis and transfecting properties of a glycosylated polycationic DNA vector.
abstract: A glycosylated analogue of dialkylamidoglycylcarboxyspermine was synthesized. The physico-chemical and transfecting properties of 11 were evaluated indicating that this cationic lipid forms stable particles at low charge ratio and is efficient for gene delivery.
authors.affiliation: LCBBMC UMR 7001 CNRS-ENSCP-Aventis-Gencell-Gencell, ENSCP, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Jacopin
authors.forename: H
authors.initials: H
authors.lastname: Hofland
authors.forename: D
authors.initials: D
authors.lastname: Scherman
authors.forename: J
authors.initials: J
authors.lastname: Herscovici
mesh_terms: D005822:Genetic Vectors / Q000378:metabolism*; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism; D006031:Glycosylation; D006367:HeLa Cells; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000138:chemical synthesis; D008823:Micelles; D011073:Polyamines / Q000138:chemical synthesis / Q000378:metabolism*; D000071228:Polyelectrolytes; D013096:Spermine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000378:metabolism; D013329:Structure-Activity Relationship; D014162:Transfection / Q000379:methods*
chemical_list: D005998:Glycine; D008055:Lipids; D008823:Micelles; D011073:Polyamines; D000071228:Polyelectrolytes; D013096:Spermine; C061134:dioctadecylamidoglycylspermine