title: [Role of grandaxin in the treatment of functional gastrointestinal diseases].
abstract: OBJECTIVE
  To assess efficacy of grandaxine in correction of anxiety syndrome and vegetative dysfunction in patients with gastrointestinal diseases.
  
  
  METHODS
  The trial included 59 patients with functional gastrointestinal, emotional and vegetative disorders who failed standard therapy. 43 patients of the test group received standard therapy in combination with grandaxine.
  
  
  RESULTS
  Anxiety (Spilberg-Khanin scale), vegetative dysfunction (Vein scale) reduced in 90% of the patients of the test group more significantly than in the control group. Intestinal passage in patients with irritable colon syndrome improved also.
  
  
  CONCLUSIONS
  A pronounced role of psychovegetative disorders was confirmed in development of functional gastrointestinal disorders. Grandaxine proved efficient in correction of such disorders irrespective of location of the pathology and prevalent tonicity of the autonomic nervous system.
authors.forename: M F
authors.initials: MF
authors.lastname: Osipenko
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Khramov
authors.forename: T A
authors.initials: TA
authors.lastname: Makarova
authors.forename: E G
authors.initials: EG
authors.lastname: Vdovenko
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy* / Q000209:etiology; D001569:Benzodiazepines; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications / Q000188:drug therapy* / Q000523:psychology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018458:Persistent Vegetative State / Q000188:drug therapy / Q000209:etiology; D013577:Syndrome; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001569:Benzodiazepines; C012582:tofisopam
vernacular_title: Rol' grandaksina v lechenii funktsional'nykh zabolevaniĭ zheludochno-kishechnogo trakta.