title: In vivo resistance of coronally induced bacterial ingress by an experimental glass ionomer cement root canal sealer.
abstract: The resistance of an experimental sealer (KT-308) to bacterial ingress was assessed in six beagle dogs. In four mandibular premolars per dog, canals were prepared, filled with condensed gutta-percha and either KT-308 or Roth 801 cement (n = 24 roots), and the pulp chambers inoculated with plaque. Two additional premolars per dog were similarly root-filled, but not inoculated (n = 12 and 11, respectively). One incisor per dog was inoculated, but not root-filled (n = 6). Dogs were terminated after 6 months, and jaw blocks were retrieved and processed for light microscopic examination of the periapical tissues. Inflammation about the inoculated roots was significantly lower (p < 0.03) for KT-308 (17%) than Roth 801 cement (46%). Inflammation about the noninoculated roots did not differ significantly between KT-308 (8%) and Roth 801 cement (36%). This study demonstrated a better functional efficacy of KT-308 than of Roth 801 cement, and validated this in vivo model for assessment of root filling materials.
authors.affiliation: Faculty of Dentistry, University of Toronto, 124 Edward Street, Toronto, Ontario M5G 1G6, Canada.
authors.forename: S
authors.initials: S
authors.lastname: Friedman
authors.forename: R
authors.initials: R
authors.lastname: Komorowski
authors.forename: W
authors.initials: W
authors.lastname: Maillet
authors.forename: R
authors.initials: R
authors.lastname: Klimaite
authors.forename: H Q
authors.initials: HQ
authors.lastname: Nguyen
authors.forename: C D
authors.initials: CD
authors.lastname: Torneck
mesh_terms: D000818:Animals; D016009:Chi-Square Distribution; D003763:Dental Leakage / Q000517:prevention & control*; D004285:Dogs; D005899:Glass Ionomer Cements; D008297:Male; D023421:Models, Animal; D012387:Root Canal Filling Materials
chemical_list: D005899:Glass Ionomer Cements; D012387:Root Canal Filling Materials