Molecular genetics and Crohn's disease.
This article reviews basic molecular genetics and summarizes recent work in the genetics of Crohn's disease. Family studies are summarized, and candidate genes are described. The current state of knowledge and the implications of possible inheritance of Crohn's disease for patient care are discussed.
Church
J M
JM
Department of Colorectal Surgery, Cleveland Clinic Foundation, Ohio 44195, USA.
D002874:Chromosome Mapping; D020090:Chromosome Segregation / Q000235:genetics; D003424:Crohn Disease / Q000453:epidemiology / Q000235:genetics*; D005826:Genetics, Medical; D006801:Humans; D008967:Molecular Biology; D009154:Mutation / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D012106:Research; D012307:Risk Factors