title: Tissue biology of apoptosis. Ref-1 and cell differentiation in the developing retina.
abstract: Programmed cell death by apoptosis plays a major role in neurogenesis. The sensitivity to apoptosis in developing nervous tissue is strongly dependent on cell interactions taking place within a highly structured environment, composed of various cell types at distinct stages of differentiation. In this article, we review evidence gathered both in vivo and in a histotypical retinal explant preparation in vitro that the bifunctional AP endonuclease/redox factor Ref-1 (HAP1, APE, APEX) may be an anti-apoptotic protein associated with cell differentiation in the developing retina.
authors.affiliation: Instituto de Biofísica da UFRJ, CCS, bloco G, Cidade Universitária, 21949-900, Rio de Janeiro, Brazil.
authors.forename: L B
authors.initials: LB
authors.lastname: Chiarini
authors.forename: R
authors.initials: R
authors.lastname: Linden
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D017209:Apoptosis / Q000502:physiology*; D019757:Carbon-Oxygen Lyases / Q000235:genetics / Q000378:metabolism*; D002454:Cell Differentiation; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase; D020287:In Situ Nick-End Labeling; D066298:In Vitro Techniques; D051381:Rats; D012160:Retina / Q000166:cytology / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism
chemical_list: D019757:Carbon-Oxygen Lyases; C470319:Apex1 protein, rat; D043603:DNA-(Apurinic or Apyrimidinic Site) Lyase