title: A clinical study of root surface conditioning with an EDTA gel. I. Nonsurgical periodontal treatment.
abstract: The present study was undertaken to investigate if subgingival administration of an EDTA gel has any adjunctive effect to subgingival and supragingival root debridement. The investigation was performed in one study center involving 6 clinical investigators and 91 patients. The patients were selected from 2 patient populations: 41 were included from a consecutive referral material on a voluntary basis, and 50 were included from a maintenance care material at the clinic. No significant differences were found between the EDTA-treated and control groups with respect to clinical attachment gain or probing pocket depth reduction. The referral patients showed a significant improvement of pocket depth and attachment gain compared to maintenance care patients at the clinic. In multiple regression analyses, it was found that patients with small attachment losses at baseline responded better to treatment than patients with severe periodontitis. Also, in multivariate analyses, referral patients responded better than maintenance patients when controlling for other predictors.
authors.affiliation: Department of Basic Oral Sciences, School of Dentistry, Karolinska Institute, and Public Dental Service, Stockholm County Council, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Blomlöf
authors.forename: E
authors.initials: E
authors.lastname: Bergman
authors.forename: A
authors.initials: A
authors.lastname: Forsgårdh
authors.forename: L
authors.initials: L
authors.lastname: Foss
authors.forename: A
authors.initials: A
authors.lastname: Larsson
authors.forename: B
authors.initials: B
authors.lastname: Sjöberg
authors.forename: L
authors.initials: L
authors.lastname: Uhlander
authors.forename: B
authors.initials: B
authors.lastname: Jonsson
authors.forename: J
authors.initials: J
authors.lastname: Blomlöf
authors.forename: S
authors.initials: S
authors.lastname: Lindskog
mesh_terms: D000328:Adult; D002614:Chelating Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D004492:Edetic Acid / Q000627:therapeutic use*; D005260:Female; D005544:Forecasting; D005782:Gels; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D017622:Periodontal Attachment Loss / Q000517:prevention & control / Q000628:therapy; D010514:Periodontal Pocket / Q000517:prevention & control / Q000628:therapy; D010518:Periodontitis / Q000145:classification / Q000517:prevention & control / Q000628:therapy*; D012017:Referral and Consultation; D012044:Regression Analysis; D016745:Root Planing; D018709:Statistics, Nonparametric; D013357:Subgingival Curettage; D014092:Tooth Root / Q000187:drug effects*; D016896:Treatment Outcome
chemical_list: D002614:Chelating Agents; D005782:Gels; D004492:Edetic Acid