p53 and Bcl-2 oncoprotein expression in placentas with hydropic changes and partial and complete moles.
Forty molar and non-molar placentas with hydropic changes (14 complete moles, 14 partial moles, and 12 hydropic non-molar placentas) were examined immunohistochemically for expression of oncoproteins p53 and Bcl-2. The data were evaluated to determine if p53 and Bcl-2 expression could aid in differentiating molar from non-molar pregnancies on the one hand and complete mole from partial mole on the other. Thirteen out of fourteen complete moles showed p53 expression (93%), 8 of the 14 partial moles expressed p53 (57%), and none of the non-molar pregnancies expressed p53 in the extravillous intermediate trophoblasts. Regarding Bcl-2, the syncytiotrophoblasts of most molar and non-molar placentas showed strong and diffuse positivity. These results suggest that p53 expression can be used as a distinguishing parameter between complete moles and placentas with hydropic changes on the one hand and to a lesser extent between partial moles and placentas with hydropic changes on the other hand. Bcl-2 cannot be used in the same way as p53.
Al-Bozom
I A
IA
Department of Pathology, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia. Bathem@ksu.edu.sa
D015415:Biomarkers / Q000032:analysis; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000737:chemistry* / Q000175:diagnosis; D015160:Hydrops Fetalis / Q000175:diagnosis / Q000378:metabolism*; D007150:Immunohistochemistry; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*; D014327:Trophoblasts / Q000737:chemistry; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D015415:Biomarkers; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53