[Weight gain and antipsychotic drug treatment].
Like the classical neuroleptic drugs, most of the new antipsychotic agents can cause weight gain in patients receiving long-term treatment. However, it remains difficult to rank the different compounds according to their propensity to cause this unwanted side-effect. Recent data suggest that weight gain appears to be essentially related to an increase in appetite in these patients. Thus, it is a fact that the patients' diet represents the main predictive factor for weight gain, independently of the antipsychotic compound prescribed. In contrast to the other and often more disabling side-effects of these treatments, overweight can be effectively prevented by simple hygienic and dietetic measures. It would therefore be advisable to discuss the possibility of this side-effect of antipsychotic treatment with the patient, and to suggest appropriate preventive measures, as part of the therapeutic partnership.
Patri
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E
Unité de psychiatrie de l'Hôtel-Dieu, 1, place du Parvis Notre-Dame, 75181 Paris.
Dantchev
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N
Martinez
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M
D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001066:Appetite / Q000187:drug effects; D004038:Diet, Reducing; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D006801:Humans; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy*; D015430:Weight Gain / Q000187:drug effects*
D014150:Antipsychotic Agents
Prise de poids et traitement antipsychotique.