Lateralized EEG findings in patients with neuropsychiatric manifestations of systemic lupus erythematosus.
Routine and quantitative EEG were used to determine whether there is a lateralized pattern of electrophysiologic dysfunction in patients with diverse neuropsychiatric manifestations of SLE. Twenty consecutive patients with neuropsychiatric symptoms of SLE underwent 20-minute EEG recordings with an 18-channel polygraph. Ten 1-second intervals were randomly selected for each patient. Once selected, the intervals were analyzed for the presence of theta and delta slow activity. Mapping was done by four-point interpolation around the 18 acquired data points. On routine EEG, abnormalities were identified in 14/20 patients with SLE. In 12/14 patients, the abnormalities were localized to the left temporal region. Quantitative EEG analyses revealed theta and delta slow activity predominantly affecting the left hemisphere in 16/19 patients with SLE. Taken together, these findings suggest selective involvement of the left hemisphere in patients with diverse neuropsychiatric manifestations of SLE.
Glanz
B I
BI
Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
Laoprasert
P
P
Schur
P H
PH
Robertson-Thompson
A
A
Khoshbin
S
S
D000328:Adult; D000368:Aged; D016009:Chi-Square Distribution; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008032:Limbic System / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000503:physiopathology