Biodegradable poly (lactic acid) microspheres for drug delivery systems.
In connection with aim of maximizing the bio-availability of conventional drugs with minimum side-effects, new drug delivery systems (DDS) continue to attracted much attention. The controlled or sustained release of drugs represents one such approach, and in this regard report upon a study of DDS using biodegradable polymers which include poly (lactic acid) (PLA), poly (glycolic acid), and their copolymers (PLGA). Much attention is being paid to the controlled release of bio-active agents from microcapsules and microspheres made of biodegradable polymers, such as lactic acid homopolymers, as well as copolymers of glycolic acid. (11-21) Microcapsules or microspheres are injectable and able to provide pre-programmed durations of action, offering several advantages over the conventional dosage forms. This article reviews the results of a work program conducted in collaboration with a medical doctor upon DDS using biodegradable microspheres, such as PLA and PLGA.
Hyon
S H
SH
Institute for Frontier Medical Sciences, Kyoto University, Japan. biogen@frontier.kyoto-u.ac.jp
D000818:Animals; D001673:Biodegradation, Environmental; D016503:Drug Delivery Systems; D006801:Humans; D019344:Lactic Acid; D008863:Microspheres; D011091:Polyesters; D011108:Polymers; D017768:Skin, Artificial
D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)