Sublethal concentration of Ambrosia maritima(Damsissa) affecting compatibility of Biomphalaria alexandrina snails to infection with Schistosoma mansoni through disturbing the glycolytic pathway.
High glycolytic flux as an emergency pathway for generating ATP was recorded as the most important metabolic pathway required for the success of Biomphalaria-Schistosome sporocyst interaction. Effect of LC25 of dry powdered Ambrosia maritima (Damsissa) as plant molluscicide on hexokinase (HK), pyruvate kinase(PK), glucose phosphate isomerase(GPI) was tested. It resulted in a significant inhibition of the three investigated enzymes. Treatment of snails with LC10 concentrations of A. maritima reduced considerably the infection rate of Biomphalaria alexandrina with Schistosoma mansoni to be 34% compared to an infection rate of 80% in control non-treated snails. Longer prepatent period and remarkable decrease in cercarial production was also recorded in snails treated with the sublethal concentrations of this molluscicide.
el-Ansary
A
A
Department of Medicinal Chemistry, National Research Centre, Dokki, Giza, Egypt.
el-Bardicy
S
S
Soliman
M S
MS
Zayed
N
N
D000818:Animals; D019659:Asteraceae / Q000737:chemistry*; D001700:Biomphalaria / Q000187:drug effects* / Q000469:parasitology*; D006019:Glycolysis / Q000187:drug effects*; D006593:Hexokinase / Q000378:metabolism; D006790:Host-Parasite Interactions / Q000187:drug effects*; D008975:Molluscacides / Q000008:administration & dosage / Q000494:pharmacology*; D010733:Phosphoglucomutase / Q000378:metabolism; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology*; D011770:Pyruvate Kinase / Q000378:metabolism; D012550:Schistosoma mansoni / Q000187:drug effects*
D008975:Molluscacides; D010936:Plant Extracts; D006593:Hexokinase; D011770:Pyruvate Kinase; D010733:Phosphoglucomutase