Gastrointestinal transit of dosage forms in the pig.
The gastrointestinal transit of liquid, pellet and tablet formulations was measured under fasted conditions in the domestic pig (n = 4) using the technique of gamma scintigraphy. The mean times for 50% gastric emptying for liquid and pellet systems were 1.4 and 2.2 h, respectively; tablets emptied between 1.5 and 6.0 h. Total transit times were in the order of 50 h. These data conform well to published values for the transit of liquid and solid food materials in the pig. The times are much shorter than those previously published for the transit of solid dosage forms in the pig. We conclude that the domestic pig would be a good model to study the gastrointestinal transit of pharmaceutical formulations and the absorption of drug compounds.
Davis
S S
SS
Institute of Pharmaceutical Sciences, University of Nottingham, UK.
Illum
L
L
Hinchcliffe
M
M
D000818:Animals; D004304:Dosage Forms; D005260:Female; D005772:Gastrointestinal Transit; D023421:Models, Animal; D011877:Radionuclide Imaging; D013552:Swine / Q000502:physiology*; D013667:Technetium
D004304:Dosage Forms; D013667:Technetium