[Anti-arrhythmic effect of the sigma-receptor blocker DuP 734 in ischemia and myocardial reperfusion].
It has been found that in vivo pretreatment of rats with the sigma receptor antagonist DuP 734 (1 mg/kg) resulted in an increase in the heart tolerance to ischemic and reperfusion arrhythmias both in vivo and ex vivo. Administration of DuP 734 (1 mg/liter) directly in the perfusion solution of isolated rat heart 10 min before total ischemia also promoted a decrease in the incidence of reperfusion arrhythmias. The normoxic perfusion of isolated rat heart at a dose of 1 mg/liter had no effect on the action potential. It was concluded that antiarrhythmic effect of DuP 734 might depend on the decrease in the Ca2+ overload but not on K+ and Na+ channel blockade.
Lishmanov
Iu B
IuB
Laboratory of Experimental Cardiology, Institute of Cardiology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, ul. Shevchenko 24, Tomsk, 634050 Russia.
Maslov
L N
LN
Krylatov
A V
AV
Afanas'ev
S A
SA
Timofeev
V Iu
VIu
Gilligan
P
P
Tam
S V
SV
D000200:Action Potentials; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D001157:Arterial Occlusive Diseases / Q000150:complications; D003327:Coronary Disease / Q000150:complications; D004562:Electrocardiography; D066298:In Vitro Techniques; D008839:Microelectrodes; D009203:Myocardial Infarction / Q000209:etiology / Q000473:pathology; D015428:Myocardial Reperfusion Injury / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009292:Narcotic Antagonists / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017480:Receptors, sigma / Q000037:antagonists & inhibitors* / Q000378:metabolism; D012598:Sclerosis / Q000517:prevention & control
D000889:Anti-Arrhythmia Agents; D009292:Narcotic Antagonists; D010880:Piperidines; D017480:Receptors, sigma; C078773:DuP 734
Issledovanie antiaritmicheskoĭ aktivnosti blokatora sigma-retseptorov DuP 734 v usloviiakh ishemii i reperfuzii miokarda.