Experimental verification of improved depth-dose distribution using hyper-thermal neutron incidence in neutron capture therapy.
We have proposed the utilization of 'hyper-thermal neutrons' for neutron capture therapy (NCT) from the viewpoint of the improvement in the dose distribution in a human body. In order to verify the improved depth-dose distribution due to hyper-thermal neutron incidence, two experiments were carried out using a test-type hyper-thermal neutron generator at a thermal neutron irradiation field in Kyoto University Reactor (KUR), which is actually utilized for NCT clinical irradiation. From the free-in-air experiment for the spectrum-shift characteristics, it was confirmed that the hyper-thermal neutrons of approximately 860 K at maximum could be obtained by the generator. From the phantom experiment, the improvement effect and the controllability for the depth-dose distribution were confirmed. For example, it was found that the relative neutron depth-dose distribution was about 1 cm improved with the 860 K hyper-thermal neutron incidence, compared to the normal thermal neutron incidence.
Sakurai
Y
Y
Kyoto University Research Reactor Institute, Osaka, Japan.
Kobayashi
T
T
D006358:Hot Temperature; D006801:Humans; D015233:Models, Statistical; D017247:Neutron Capture Therapy / Q000379:methods*; D009502:Neutrons / Q000627:therapeutic use*; D019047:Phantoms, Imaging; D011874:Radiometry / Q000379:methods*; D013696:Temperature; D014867:Water
D014867:Water