title: Tissue expander: histological and histochemical study 6 months after transplant--our experience.
abstract: Implanting an expander in the subcutaneous layer causes gradual expansion and provides additional tissue for reconstruction of tissular defects. The force applied remodels the connective tissue and modifies dermis contractibility in additional tissue. Other authors confirm that parameters such as mitosis and hyaluronan influence the system in the tissue regeneration processes. We studied histochemical and morphological variations of tissue expanders before and 6 months after transplant. Our histochemical data do not show any changes in dermis glycosaminoglycans of the expanded and transplant-expanded skin when compared to controls. Morphological data demonstrate reorganization of connective fibers and disappearance of the papillar layer. The latter is not yet formed in the expanded skin 6 months after transplant. This suggests that a long time is required for biological reconstruction of epidermal-dermal interactions after transplant.
authors.affiliation: Instituto di Anatomia Umana Normale, Università Statale di Milano, Facoltà di Medicina e Chirurgia, Via Mangiagalli, 31, 20133 Milano, Italy. stg@dns.unife.it
authors.forename: G
authors.initials: G
authors.lastname: Stabellini
authors.forename: C
authors.initials: C
authors.lastname: Calastrini
authors.forename: A
authors.initials: A
authors.lastname: Marcucci
authors.forename: M
authors.initials: M
authors.lastname: De Mattei
authors.forename: M I
authors.initials: MI
authors.lastname: Luna-Carbonel
authors.forename: A
authors.initials: A
authors.lastname: Pellati
authors.forename: G
authors.initials: G
authors.lastname: Mariani
authors.forename: A
authors.initials: A
authors.lastname: Franchella
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005109:Extracellular Matrix / Q000473:pathology* / Q000648:ultrastructure*; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D008854:Microscopy, Electron; D013524:Surgical Flaps; D015625:Tissue Expansion Devices / Q000009:adverse effects*