[Roles of neuropeptide Y in the expression of anticipatory corticosterone peak in rats under restricted daily feeding].
NPYmRNA in the arcuate nucleus (ARC) and the nucleus of the solitary tract (NST) was measured by quantitative RT-PCR and in situ hybridization in rats under 48-hour food deprivation (FD) or under restricted daily feeding (RF) in which free access to food was restricted to 2 hours per day for 3 weeks. Plasma corticosterone levels were elevated immediately prior to daily food supply under RF, while they remained essentially unchanged by 48-hour FD. On the other hand, the NPYmRNA levels in the ARC were increased by 48-hour FD and RF, while those in the NST were elevated by RF but not by 48-hour FD. These findings indicate that the NPY neurons in the NST are specifically involved in the prefeeding corticosterone peak in the rats the under RF, while the NPY neurons in the ARC are involved in the feeding activity in general and stimulated by decreased food availability.
Ishizaki
K
K
Department of Physiology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism; D002940:Circadian Rhythm / Q000502:physiology; D003345:Corticosterone / Q000097:blood*; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D009478:Neuropeptide Y / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017552:Solitary Nucleus / Q000378:metabolism
D009478:Neuropeptide Y; D003345:Corticosterone