VEGF is causative for pulmonary hypertension in a patient with Crow-Fukase (POEMS) syndrome.
We report a case of Crow-Fukase (POEMS) syndrome associated with pulmonary hypertension (PH). In this case, the concentration of vascular endothelial growth factor (VEGF) was extremely high in the serum, and the levels of IL-1beta, IL-6, TNF-alpha, and thiamine, which were thought in past reports to be mediators of PH in Crow-Fukase syndrome, were normal. After prednisolone therapy, PH disappeared with a dramatic decrease in serum VEGF. Our results suggest that VEGF is closely correlated with PH in Crow-Fukase syndrome.
Niimi
H
H
Third Department of Internal Medicine, Kagoshima University.
Arimura
K
K
Jonosono
M
M
Hashiguchi
T
T
Kawabata
M
M
Osame
M
M
Kitajima
I
I
D016207:Cytokines / Q000097:blood; D016228:Endothelial Growth Factors / Q000097:blood*; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008222:Lymphokines / Q000097:blood*; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D016878:POEMS Syndrome / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D011239:Prednisolone / Q000627:therapeutic use; D014262:Tricuspid Valve Insufficiency / Q000209:etiology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016207:Cytokines; D016228:Endothelial Growth Factors; D007166:Immunosuppressive Agents; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D011239:Prednisolone; D008775:Methylprednisolone