Effect of dissolution fluid and presence of hog intestinal barrier on the dissolution of theophylline from bioadhesive granules.
The effect of dissolution fluid and the presence of a natural barrier (hog intestine) on the release of theophylline from some bioadhesive granules is presented. A higher quantity of the drug was released in simulated intestinal fluid (SIF) than O. IN HCl. When a hog intestine was used as the diffusion barrier, the availability of the drug through the barrier into the sink solution was low, ranging from 20-35%.
Adikwu
M U
MU
Department of Pharmaceutics and Pharmaceutical Microbiology, Faculty of Pharmaceutical Sciences, Ahmadu Bello University, Zaria, Nigeria.
Ojile
J E
JE
Okoli
N D
ND
D000269:Adhesives; D000818:Animals; D001993:Bronchodilator Agents / Q000737:chemistry / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D051379:Mice; D009077:Mucins / Q000737:chemistry; D051381:Rats; D012995:Solubility; D013552:Swine; D013806:Theophylline / Q000737:chemistry / Q000378:metabolism*
D000269:Adhesives; D001993:Bronchodilator Agents; D009077:Mucins; D013806:Theophylline