title: Pancreatobiliary adenosquamous carcinoma (report of two cases).
abstract: Adenosquamous carcinomas are rare malignant tumors of the pancreas and periampullary region. We present two cases of pancreatic and periampullary adenosquamous carcinoma with clinicopathologic, histo- and immunohistochemical findings. A 51-year-old and a 48-year-old man presented with right upper quadrant pain of three months duration and jaundice for two weeks. Both cases had an elevation of liver enzymes and CA 19-9. In the first case, computerized tomography showed a 3 cm-mass at the pancreatic head. In the second one, endoscopic retrograde choledocopancreatography (ERCP) revealed a mass at the ampulla Vateri localization. A pancreatoduodenectomy was performed for both cases. Gross pathologic examination displayed a solid, gray-white colored 4 cm-tumor at the pancreatic head and a solid, pink-white colored, 2 cm-tumor at the periampullary region bulging into the duodenal lumen. Microscopically, both tumors were composed of solid nests of squamous cells with pearl formation and mucin-containing glandular cells and diagnoses were adenosquamous carcinoma. Furthermore, histo- and immunohistochemical findings were consistent with microscopic diagnoses.
authors.affiliation: Department of Pathology, Istanbul Medical Faculty, Istanbul, Turkey. ekremyavuz@ixir.com
authors.forename: E
authors.initials: E
authors.lastname: Yavuz
authors.forename: Y
authors.initials: Y
authors.lastname: Kapran
authors.forename: I
authors.initials: I
authors.lastname: Ozden
authors.forename: T
authors.initials: T
authors.lastname: Bulut
authors.forename: F
authors.initials: F
authors.lastname: Dizdaroğlu
mesh_terms: D014670:Ampulla of Vater / Q000473:pathology*; D018196:Carcinoma, Adenosquamous / Q000473:pathology*; D003138:Common Bile Duct Neoplasms / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology*