title: [Extracorporeal detoxication in combined treatment of surgical sepsis].
abstract: The methods of extracorporeal detoxication acquire special importance in combined treatment of sepsis. The sessions of plasmapheresis, hemodialysis and isolated ultrafiltration were performed in 61 of 83 patients with sepsis. Indications to these methods are determined, their efficacy is evaluated. It is established that administration of antibiotics and immunoglobulins after sessions of plasmapheresis and hemodialysis to achieves therapeutic drug concentration in blood. It is difficult to select the dose of antibiotics and immunodrugs in permanent round-the-clock ultrafiltration since the part of them are eliminated through the filters. Overall lethality was 20.4% (17 of 83 patients died), in the group of patients with severe polyorganic insufficiency and septic shock who needed extracorporeal detoxication--27%.
authors.forename: E A
authors.initials: EA
authors.lastname: Reshetnikov
authors.forename: M V
authors.initials: MV
authors.lastname: Chuvanov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Denisov
authors.forename: G F
authors.initials: GF
authors.lastname: Shipilov
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D011379:Prognosis; D006435:Renal Dialysis; D012189:Retrospective Studies; D018805:Sepsis / Q000097:blood / Q000401:mortality / Q000628:therapy*; D013530:Surgical Wound Infection / Q000097:blood / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate; D014462:Ultrafiltration
chemical_list: D000900:Anti-Bacterial Agents; D007136:Immunoglobulins
vernacular_title: Ekstrakorporal'naia detoksikatsiia v kompleksnom lechenii khirurgicheskogo sepsisa.