[Benzodiazepines and pregnancy].
The use of benzodiazepines is not negligible in pregnant woman and self-medication is considerable. To investigate the effects on the fetus of benzodiazepines used during pregnancy, we reviewed animal and clinical studies completed with observations of CRPV (Centres Régionaux de Pharmacovigilance). Pooled results indicate that the risk of malformations associated with first-trimester exposure to benzodiazepines remains small. However, in a fetus exposed essentially to long-acting benzodiazepines on a long-term basis, neonatal hypotonicity, failure to feed and/or withdrawal syndrom could be observed.
Pérault
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MC
Service de Pharmacologie Clinique, CRPV, CHU La Milétrie, 350 avenue Jacques Coeur BP 577, 86021 Poitiers, France.
Favrelière
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Minet
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Remblier
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C
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology / Q000209:etiology*; D000328:Adult; D000818:Animals; D014151:Anti-Anxiety Agents / Q000009:adverse effects / Q000145:classification / Q000493:pharmacokinetics / Q000633:toxicity; D000927:Anticonvulsants / Q000009:adverse effects / Q000145:classification / Q000493:pharmacokinetics / Q000633:toxicity; D001569:Benzodiazepines / Q000009:adverse effects* / Q000145:classification / Q000493:pharmacokinetics / Q000633:toxicity; D002971:Cleft Lip / Q000139:chemically induced; D002972:Cleft Palate / Q000139:chemically induced; D002986:Clinical Trials as Topic; D000075202:Contraindications; D006224:Cricetinae; D004353:Drug Evaluation, Preclinical; D005260:Female; D005602:France / Q000453:epidemiology; D006552:Hernia, Inguinal / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D051379:Mice; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011446:Prospective Studies; D011817:Rabbits; D051381:Rats; D012042:Registries; D012651:Self Medication; D013375:Substance Withdrawal Syndrome / Q000209:etiology
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001569:Benzodiazepines
Benzodiazépines et grossesse.