[Pathomorphological characteristics of cerebral arterioles and capillaries in surgical epileptic patients with generalized seizures].
Clinical and morphological analyses of brain biopsy specimens from epileptic patients undergone surgery have indicated that the brain vascular system in epilepsy has the most vulnerable site, namely: pre-capillary arterioles and capillaries. At the same time, the paper describes some dissimilarities of qualitative and quantitative characteristics of the above vessels from their changes in hypertensive angiopathy. There was a relationship of arteriolar changes to the duration and severity of epilepsy. The use of silver-impregnated serial brain sections revealed 5 types of cerebral capillary morphological changes that could be arranged in successive stages of transformation (neocapillarogenesis). There was an association of the activation of neocappilarogenesis with the duration and severity of epilepsy. It forms an impression that the life of a capillary is shorter due to its accelerated morphofunctional evolution particularly in patients with advanced epilepsy. This is accompanied by the rates of neocapillarogenesis that is regarded as a compensatory and adaptive response of the brain capillary system.
Beĭn
B N
BN
Larionov
S V
SV
Khorobrykh
V G
VG
D000293:Adolescent; D000328:Adult; D001160:Arterioles / Q000473:pathology; D001706:Biopsy; D002196:Capillaries / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply* / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004829:Epilepsy, Generalized / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008853:Microscopy
Osobennosti patomorfologii tserebral'nykh arteriol i kapilliarov u operirovannykh bol'nykh épilepsieĭ s generalizovannymi pripadkami.