title: Involvement of type I and type II mechanisms in the linoleic acid peroxidation photosensitized by tiaprofenic acid.
abstract: Analysis of the photomixtures resulting from irradiation of aqueous solutions of linoleic acid sensitized by tiaprofenic acid (TPA) or its major photoproduct (DTPA) by HPLC has shown the formation of all the four possible conjugated dienic hydroperoxides. According to laser flash photolysis experiments the rate constants for hydrogen abstraction from linoleic acid by the excited triplet states of TPA and DTPA are 2 x 10(5) and 3.2x 10(5) M(-1) s(-1), respectively. These data, together with the known rate constants for oxygen quenching of triplet (D)TPA and for the reaction of singlet oxygen with linoleic acid, show that the mechanism is mixed type I/type II. Finally, typical radical scavengers such as BHA and singlet oxygen quenchers such as DABCO and sodium azide are efficient quenchers of the triplet excited state of DTPA. This shows the risk of assigning mechanisms based on indirect 'evidences' using 'specific' additives.
authors.affiliation: Departamento de Química, Instituto de Tecnología Química UPV-CSIC, Universidad Politécnica de Valencia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Boscá
authors.forename: M A
authors.initials: MA
authors.lastname: Miranda
authors.forename: I M
authors.initials: IM
authors.lastname: Morera
authors.forename: A
authors.initials: A
authors.lastname: Samadi
mesh_terms: D007834:Lasers; D019787:Linoleic Acid / Q000737:chemistry*; D015227:Lipid Peroxidation; D010782:Photolysis; D017319:Photosensitizing Agents / Q000737:chemistry*; D011422:Propionates / Q000737:chemistry*
chemical_list: D017319:Photosensitizing Agents; D011422:Propionates; C021270:tiaprofenic acid; D019787:Linoleic Acid