Relationship between infiltrating cells and adhesion molecules in the nasal mucosa of patients with allergic rhinitis.
Antigen-induced changes of cell adhesion molecules and their relationships to infiltrating cells were investigated immunohistochemically in nasal mucosa of perennial allergic rhinitis patients. An increased expression of E-selectin and VCAM-1 was noted on the vascular endothelium of the nasal mucosa 15-25 h after the topical antigen challenge. Although there was no increased expression of ICAM-1, we noted a positive correlation between the expression of E-selectin and ICAM-1. The expression of E-selectin and VCAM-1 as well as ICAM-1 was revealed to be correlated with the number of EG2-positive cells and CD4-positive cells, but not with elastase-positive cells. These findings suggest that all these adhesion molecules play a role in the topical influxes of eosinophils and CD4-positive cells in allergic nasal mucosa.
Matsui
T
T
Department of Otolaryngology, Sapporo Medical University, School of Medicine, Hokkaido, Japan.
Asakura
K
K
Shirasaki
H
H
Kataura
A
A
Himi
T
T
D000293:Adolescent; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000502:physiology*; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000276:immunology*; D020556:Neutrophil Infiltration / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*
D015815:Cell Adhesion Molecules