title: [Inhaled corticosteroids and wheezing post-bronchiolitis].
abstract: OBJECTIVE
  To determine whether inhaled corticosteroid therapy given for 3 months after mild bronchiolitis decreases the incidence and/or severity of wheezing in the following 12 months.
  
  
  METHODS
  Multicentric, single-blind, controlled, randomised intervention study.
  
  
  METHODS
  Primary Health Care Centers in Lezo, Beraun, Andoain and Irún (Gipuzkoa, Spain).
  
  
  METHODS
  Infants less than 12 months old (n = 94) diagnosed with mild bronchiolitis.
  
  
  METHODS
  We established two groups of patients: group 1 (n = 47) was treated with inhaled beclomethasone (250 pg/12 hours) using a valved holding chamber (Babyhaler); the treatment started eight days after diagnosis of bronchiolitis and lasted 3 months. Group 2 (n = 47) received no treatment. We compared the number of wheezing episodes and their severity during the intervention period (3 months) and the follow-up period (12 months) with the Students t-test and the Chi-squared test.
  
  
  RESULTS
  We studied 89 infants (group 1, n = 42; group 2, n = 47), 67% of whom wheezed during the study period (15 months). There were no significant differences between the treatment and the control group in the study periods.
  
  
  CONCLUSIONS
  Inhaled beclomethasone given for 3 months does not significantly modify the occurrence of wheezing episodes during the treatment period or during the following 12 months.
authors.affiliation: CAP de Amara Centro, Beraun, Andoain e Irún.
authors.forename: M
authors.initials: M
authors.lastname: Callén Blecua
authors.forename: P
authors.initials: P
authors.lastname: Aizpurua Galdeano
authors.forename: I
authors.initials: I
authors.lastname: Ozcoidi Erro
authors.forename: L
authors.initials: L
authors.lastname: Mancisidor Aguinagalde
authors.forename: C
authors.initials: C
authors.lastname: Guedea Adiego
authors.forename: E
authors.initials: E
authors.lastname: Busselo Ortega
authors.forename: I
authors.initials: I
authors.lastname: Ibarrondo Uriarte
mesh_terms: D000280:Administration, Inhalation; D001507:Beclomethasone / Q000008:administration & dosage*; D001988:Bronchiolitis / Q000188:drug therapy*; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008297:Male; D012135:Respiratory Sounds / Q000187:drug effects*; D016037:Single-Blind Method
chemical_list: D005938:Glucocorticoids; D001507:Beclomethasone
vernacular_title: Glucocorticoides inhalados y sibilancias posbronquiolitis.