Genomic structure, alternative splicing, and physical mapping of the killer cell lectin-like receptor G1 gene (KLRG1), the mouse homologue of MAFA.
The mouse killer cell lectin-like receptor G1 (KLRG1), the mouse homologue of the mast cell function-associated antigen (MAFA), is an inhibitory C-type lectin expressed on natural killer (NK) cells and activated CD8 T cells. Here we report the complete nucleotide sequence, alternatively spliced variants, and the physical mapping of the KLRG1 gene in the mouse. The gene spans about 13 kb and consists of five exons. Short interspersed repeats of the B1 and B2 family, a LINE-1-like element, and a (CTT)170 triplet repeat were found in intron sequences. In contrast to human KLRG1 and to the murine KLR family members, mouse KLRG1 locates outside the NK complex on Chromosome 6 between the genes encoding CD9 and CD4.
Voehringer
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Institute for Medical Microbiology and Hygiene, Department of Immunology, University of Freiburg, Germany.
Kaufmann
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Pircher
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D017398:Alternative Splicing / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D015139:Blotting, Southern; D003001:Cloning, Molecular; D005091:Exons / Q000235:genetics*; D023061:Gene Order / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000378:metabolism*; D037102:Lectins / Q000737:chemistry*; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D020161:Physical Chromosome Mapping; D011971:Receptors, Immunologic; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D015534:Trans-Activators
C113413:KLRG1 protein, human; C451496:Klrg1 protein, mouse; C094696:Klrg1 protein, rat; D037102:Lectins; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D015534:Trans-Activators