title: Frontal lobe disinhibition, Rett syndrome and attention deficit hyperactivity disorder.
abstract: Motor cortex hyperexcitability in Rett Syndrome (RS) has been ascribed to the failure of an inhibiting system arising from the frontal lobes, a system needed in childhood and early adolescence. It is also presumed that, on a virtually dysfunctional (nonstructural) basis, motor cortex hyperexcitability in ADHD is also due to insufficient frontal lobe inhibition ("lazy frontal lobe"). A series of schematic illustrations is added for the sake of easier comprehension of the presented concept.
authors.affiliation: Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
authors.forename: E
authors.initials: E
authors.lastname: Niedermeyer
mesh_terms: D000293:Adolescent; D000328:Adult; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy / Q000503:physiopathology*; D000697:Central Nervous System Stimulants / Q000627:therapeutic use; D002648:Child; D002657:Child Development; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008774:Methylphenidate / Q000627:therapeutic use; D009044:Motor Cortex / Q000503:physiopathology*; D015518:Rett Syndrome / Q000503:physiopathology*
chemical_list: D000697:Central Nervous System Stimulants; D008774:Methylphenidate