title: p53 and p21 are major cellular determinants for DNA topoisomerase I-mediated radiation sensitization in mammalian cells.
authors.affiliation: Department of Radiation Oncology, Vanderbilt University Medical Center, 1301 22nd Ave. S., Vanderbilt Clinic, Nashville, TN 37232-5671, USA. Allan.chen@mcmail.vanderbilt.edu
authors.forename: A Y
authors.initials: AY
authors.lastname: Chen
authors.forename: P B
authors.initials: PB
authors.lastname: Scruggs
authors.forename: L
authors.initials: L
authors.lastname: Geng
authors.forename: M L
authors.initials: ML
authors.lastname: Rothenberg
authors.forename: D E
authors.initials: DE
authors.lastname: Hallahan
mesh_terms: D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D016466:CHO Cells / Q000187:drug effects / Q000528:radiation effects; D002166:Camptothecin / Q000494:pharmacology; D006224:Cricetinae; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins / Q000502:physiology*; D004264:DNA Topoisomerases, Type I / Q000502:physiology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D011836:Radiation Tolerance / Q000187:drug effects / Q000502:physiology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology; D059004:Topoisomerase I Inhibitors; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects; D016159:Tumor Suppressor Protein p53 / Q000502:physiology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; C493956:CDKN1A protein, human; D050759:Cyclin-Dependent Kinase Inhibitor p21; D016213:Cyclins; D004791:Enzyme Inhibitors; D011838:Radiation-Sensitizing Agents; D059004:Topoisomerase I Inhibitors; D016159:Tumor Suppressor Protein p53; D004264:DNA Topoisomerases, Type I; D002166:Camptothecin