New anti-MRSA cephalosporins with a basic aminopyridine at the C-7 position.
Incorporation of a basic aminopyridine into the C-7 position of 3-(amine-substituted arylthio)-3-norcephalosporins, as in 3, afforded high potency against MRSA and acceptable solubility for intravenous administration.
Cho
A
A
Microcide Pharmaceuticals, Inc., Mountain View, CA 94043, USA. acho@microcide.com
Glinka
T W
TW
Ludwikow
M
M
Fan
A T
AT
Wang
M
M
Hecker
S J
SJ
D000631:Aminopyridines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D020650:Combinatorial Chemistry Techniques; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000631:Aminopyridines; D002511:Cephalosporins; C420727:RWJ 54428