[Monocytic B-cells represent a new cell population that is mainly recruited from unmutated polyconal naive B-cells].
Monocytoid B-cells appear as a distinct B-cell population in a number of lymphadenopathies but above all in Piringer's lymphadenopathy. Up until now, their assignment to a recognised B-cell subpopulation has not been conclusively achieved. Immunohistological studies have shown characteristics in common with the tumour cells of hairy cell leukemia and also with so-called splenic marginal zone cells. In order to unequivocally clarify their B-cell differentiation stage we have isolated single monocytoid B-cells from immunostained frozen sections and have analysed their immunoglobulin chain gene rearrangements. In addition we have studied the Ig-expression of monocytoid B-cells at both the RNA and protein levels.
Stein
K
K
Institut für Pathologie, Universitätsklinikum Benjamin Franklin, Freie Universität Berlin.
Hummel
M
M
Korbjuhn
P
P
Foss
H D
HD
Anagnostopoulos
I
I
Marafioti
T
T
Stein
H
H
D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology*; D002454:Cell Differentiation; D015321:Gene Rearrangement; D005803:Genes, Immunoglobulin; D006801:Humans; D007128:Immunoglobulin Fragments / Q000235:genetics; D007943:Leukemia, Hairy Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology; D008206:Lymphatic Diseases / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D009000:Monocytes / Q000276:immunology / Q000473:pathology
D007128:Immunoglobulin Fragments
Monozytoide B-Zellen stellen eine neue B-Zellpopulation dar, die sich zumeist aus polyklonalen unmutierten naiven B-Zellen rekrutiert.