title: Heteroaryl and cycloalkyl sulfonamide hydroxamic acid inhibitors of matrix metalloproteinases.
abstract: Heteroaryl and cycloalkyl sulfonamide-hydroxamic acid MMP inhibitors were investigated. Of these, the pyridyl analogue 2 is the most potent and selective inhibitor of MMP-9 and MMP-13 in vitro.
authors.affiliation: Wyeth-Ayerst Research, Pearl River, NY 10965, USA. levinji@war.wyeth.com
authors.forename: J I
authors.initials: JI
authors.lastname: Levin
authors.forename: Y
authors.initials: Y
authors.lastname: Gu
authors.forename: F C
authors.initials: FC
authors.lastname: Nelson
authors.forename: A
authors.initials: A
authors.lastname: Zask
authors.forename: J F
authors.initials: JF
authors.lastname: DiJoseph
authors.forename: M A
authors.initials: MA
authors.lastname: Sharr
authors.forename: A
authors.initials: A
authors.lastname: Sung
authors.forename: G
authors.initials: G
authors.lastname: Jin
authors.forename: R
authors.initials: R
authors.lastname: Cowling
authors.forename: P
authors.initials: P
authors.lastname: Chanda
authors.forename: S
authors.initials: S
authors.lastname: Cosmi
authors.forename: C L
authors.initials: CL
authors.lastname: Hsiao
authors.forename: W
authors.initials: W
authors.lastname: Edris
authors.forename: J
authors.initials: J
authors.lastname: Wilhelm
authors.forename: L M
authors.initials: LM
authors.lastname: Killar
authors.forename: J S
authors.initials: JS
authors.lastname: Skotnicki
mesh_terms: D000818:Animals; D020650:Combinatorial Chemistry Techniques; D006801:Humans; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D053509:Matrix Metalloproteinase 13; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D062367:ortho-Aminobenzoates / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D013449:Sulfonamides; D062367:ortho-Aminobenzoates; C507079:MMP13 protein, human; D053509:Matrix Metalloproteinase 13