Cytokines and hormones with anti-inflammatory effects: new tools for therapeutic intervention.
The inflammation that is involved in the development of glomerulonephritis is tightly regulated by the expression of anti-inflammatory factors. These include circulating hormones, such as glucocorticoids, and mediators that are produced by intrinsic cells and infiltrating leucocytes. The present review focuses on these anti-inflammatory factors, summarizing in particular their activities in existing models of glomerulonephritis. In addition, experimental evidence is presented that anti-inflammatory mediators are able to increase glucocorticoid binding or signalling in target cells. These data help to explain the in-vivo efficacy of anti-inflammatory mediators, and offer a promising new avenue for therapeutic intervention.
Baud
L
L
Unité INSERM 489 and Service d'Explorations Fonctionnelles Multidisciplinaires, H pital Tenon, Paris, France. laurent.baud@tnn.ap-hop-paris.fr
Fouqueray
B
B
Bellocq
A
A
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D016207:Cytokines / Q000627:therapeutic use*; D005921:Glomerulonephritis / Q000188:drug therapy*; D005938:Glucocorticoids / Q000627:therapeutic use; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans
D000893:Anti-Inflammatory Agents; D016207:Cytokines; D005938:Glucocorticoids; D006728:Hormones