Effect of pentoxifylline on cyclosporine-induced nephrotoxicity in rats.
Effect of unique hemorrheologic agent pentoxifylline (PTX) was investigated on cyclosporine (CsA) induced nephrotoxicity in rats. Compared to saline control, CsA produced significant increase in blood urea and serum creatinine. Pentoxifylline treatment prevented the CsA-induced rise in blood urea and serum creatinine. Creatinine clearance (Ccr) and lithium clearance (Licr) was decreased with CsA. PTX treatment prevented the CsA-induced decrease in Ccr and Licr. Malondialdehyde (MDA) was increased with CsA compared to saline treated animals. PTX prevented the CsA-induced MDA rise. Kidney form CsA treated rat showed marked vacuolar degeneration of tubular epithelium with excess of microcalcification. Severity of the lesions was markedly reduced in rats treated with PTX plus CsA. The results indicate that PTX reduces CsA-induced renal toxicity in rats.
Shifow
A A
AA
Central Research Laboratory, Departments of Clinical Pharmacology & Therapeutics, Nizam's Institute of Medical Sciences, Hyderabad 500482, India.
Naidu
M U
MU
Kumar
K V
KV
Prayag
A
A
Ratnakar
K S
KS
D000818:Animals; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors / Q000633:toxicity; D007668:Kidney / Q000187:drug effects* / Q000473:pathology / Q000503:physiopathology; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014508:Urea / Q000097:blood; D014665:Vasodilator Agents / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D014665:Vasodilator Agents; D016572:Cyclosporine; D014508:Urea; D003404:Creatinine; D010431:Pentoxifylline