title: [Thrombotic thrombocytopenic purpura (TTP) or Moschowitz syndrome. Our experience].
abstract: OBJECTIVE
  The aim of this study was to report that Moschcowitz's syndrome was an inexorable cause of death in our Centre in the cases we observed, all of which failed to respond to the treatment used. This severe prognosis was attributed to the irreversible nature of the pathology when the patients were admitted to intensive care.
  
  
  METHODS
  Three cases are described which were brought to our attention with this pathology. The following association was present in all cases: low platelet count, anemia with schistocytosis and indirect hyperbilirubinemia. Plasmapheresis was the main treatment used in all cases.
  
  
  METHODS
  the intensive care unit of our Hospital is the regional reference centre where plasmapheresis is performed.
  
  
  METHODS
  Three patients were studied: two females aged 62 and 42 respectively, and one male aged 63. All three patients came from this region and no special features were found in their long-term medical history.
  
  
  METHODS
  all patients underwent blood transfusion, plasmapheresis and received targeted antibiotic and corticosteroid treatment, and parenteral nutrition.
  
  
  RESULTS
  All three cases died.
  
  
  CONCLUSIONS
  The analysis of these cases highlights the need for an early diagnosis, even if this is not easy, in order to commence successful therapy.
authors.affiliation: Servisio di Anestesia e Rianimazione, Azienda Sanitaria Locale n. 3, Presidio Ospedaliero Cardarelli, Campobasso.
authors.forename: G
authors.initials: G
authors.lastname: Iannandrea
authors.forename: R
authors.initials: R
authors.lastname: Flocco
authors.forename: M
authors.initials: M
authors.lastname: Flocco
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010956:Plasmapheresis; D011379:Prognosis; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis / Q000401:mortality* / Q000628:therapy
vernacular_title: Porpora trombotica trombocitopenica (TTP) o sindrome di Moschowitz. Nostra esperienza.