Plasma levels of the chemokine RANTES in macaque monkeys infected with pathogenic and non-pathogenic SIV/HIV-1 chimeric viruses at an early stage of infection.
Plasma levels of the chemokine RANTES were examined in monkeys infected with either a pathogenic simian and human immunodeficiency chimeric virus (SHIV) or a non-pathogenic SHIV to determine whether RANTES levels were related to the pathogenicity of the virus, the plasma viral load, or the kinetics of CD4+ T-cells. In the results no significant correlation was found between the RANTES kinetics and changes in the CD4+ T-cell numbers nor the plasma viral loads in any of the monkeys, although a transient decrease of the RANTES level was observed in the pathogenic virus-infected monkeys. At least, the plasma RANTES level can not be used as an index of the pathogenicity of the virus at the early stage of infection.
Kwofie
T B
TB
Research Center for AIDS, Laboratory of Viral Pathogenesis, Institute for Virus Research, Kyoto University, Japan.
Haga
T
T
Iida
T
T
Hayami
M
M
Miura
T
T
D000818:Animals; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes; D018946:Chemokine CCL5 / Q000097:blood*; D002678:Chimera; D004797:Enzyme-Linked Immunosorbent Assay / Q000662:veterinary; D006678:HIV / Q000276:immunology / Q000472:pathogenicity*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D006801:Humans; D007700:Kinetics; D008251:Macaca; D008992:Monkey Diseases / Q000276:immunology* / Q000821:virology; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000472:pathogenicity*
D018946:Chemokine CCL5