Toxic epidermal necrolysis after the use of high-dose cytosine arabinoside.
We report a fatal case of toxic epidermal necrolysis (TEN) resulting from a high dose of cytosine arabinoside (ARA-C). A 13-year-old girl with acute lymphocytic leukemia was treated according to the protocol of the BFM Group (BFM-95, HRG). On the fifth day after administration of a high dose of ARA-C (2 g/m2 intravenously every 12 hours), she developed bullous lesions on the hands and soles that disseminated, evolving to necrosis, sepsis, and death on the 22nd day. ARA-C is frequently associated with dermatologic toxicity, but this is only the second case of toxic epidermal necrolysis described in connection with this drug.
Ozkan
A
A
Cerrahpasa Medical Faculty, Department of Pediatric Hematology-Oncology, University of Istanbul, Istanbul, Turkey. alpok74@hotmail.com
Apak
H
H
Celkan
T
T
Yüksel
L
L
Yildiz
I
I
D000005:Abdomen; D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001132:Arm; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006257:Head; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D013262:Stevens-Johnson Syndrome / Q000209:etiology*
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine