title: Level of malondialdehyde after short-time omeprazole administration.
abstract: BACKGROUND
  Omeprazole is a proton pump inhibitor of increasingly wide application in the treatment of different gastroenterological diseases. The purpose of the study was to evaluate the effect of omeprazole (O) on the level of plasma malondialdehyde (MDA).
  
  
  METHODS
  Omeprazole was administered intraperitoneally to male Wistar rats twice a day, for 3 days, in two doses: O1-0.57 mg/kg body weight (b.w.), O2-5.71 mg/kg b.w. Twelve hours after the last injection half of the animals were terminated (I). The remaining rats were kept for the next 6 weeks without any xenobiotics (II). The blood was taken from the still beating heart and then centrifuged. The plasma level of MDA was determined and compared to the 1 mg of the blood protein.
  
  
  RESULTS
  A significant (p < 0.05) increase of MDA level was found in the O2II group, as compared with the O2I group. The level of MDA was higher after 6 weeks' period in relation to the animals that were terminated on the 4th day of the experiment.
  
  
  CONCLUSIONS
  Three-day omeprazole administration did not change the MDA level in the rat plasma.
authors.affiliation: Experimental Teratology Unit, Department of Human Anatomy, Medical University, ul. Spokojna 1, 20-074 Lublin, Poland. frank@tkt.net.pl
authors.forename: F
authors.initials: F
authors.lastname: Burdan
authors.forename: B
authors.initials: B
authors.lastname: Burak
authors.forename: A
authors.initials: A
authors.lastname: Sek
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D009853:Omeprazole / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013997:Time Factors
chemical_list: D000897:Anti-Ulcer Agents; D008315:Malondialdehyde; D009853:Omeprazole