PAC1 null females display decreased fertility.
We report here that PAC1 KO females display decreased fertility, whereas male fertility was normal. ICC on pituitary section showed that FSH, LH, and prolactin synthesis were not affected in KO mice. Moreover, the pituitary-gonadal axis responded properly to an acute fasting test in KO mice. Hence, the phenotype of PAC1 null mice provides clear evidence for the role of PAC1 receptor in reproduction process.
Jamen
F
F
CNRS-UPR 9023, Centre CNRS-INSERM de Pharmacologie-Endocrinologie, 141 Rue de la Cardonille, 34094 Montpellier, France. Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Universidad de Alcalá, E-28871 Alcalá de Henares, Spain.
Rodriguez-Henche
N
N
Pralong
F
F
Jegou
B
B
Gaillard
R
R
Bockaert
J
J
Brabet
P
P
D000818:Animals; D005260:Female; D005298:Fertility / Q000235:genetics* / Q000502:physiology*; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007150:Immunohistochemistry; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D010903:Pituitary Gland, Anterior / Q000502:physiology; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone / Q000235:genetics* / Q000502:physiology*; D012669:Seminal Vesicles / Q000502:physiology; D012727:Sex Characteristics; D014599:Uterus / Q000502:physiology
C495504:Adcyap1r1 protein, mouse; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone