title: [Two cases of episodic angioedema associated with eosinophilia].
abstract: We experienced two cases of limb edema of unknown pathogenesis. No evidence was found concerning involvement of the kidneys, heart of other visceral organs. Case 1 was 22-year-old woman. Her white blood cell count increased to 13,100/microliter with 65.0% eosinophils. Case 2 was a 27-year-old woman. Her white blood cell count increased to 23,300/microliter with 67.0% eosinophils. In these cases, extensive diagnostic evaluations revealed no evidence of atopy, neoplasms, collagen-vascular disease, or parasitic infestation. We diagnosed these cases as episodic angioedema with eosinophilia. In both cases, the angioedema improved gradually in parallel with a decrease in the white blood cell count. This disorder is very rare, but it is very important to consider it in differential diagnosis especially for nephrologists.
authors.affiliation: Division of Nephrology and Metabolism, School of Medicine, Tokai University, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Toyoda
authors.forename: D
authors.initials: D
authors.lastname: Suzuki
authors.forename: G
authors.initials: G
authors.lastname: Uehara
authors.forename: T
authors.initials: T
authors.lastname: Umezono
authors.forename: T
authors.initials: T
authors.lastname: Horiki
authors.forename: M
authors.initials: M
authors.lastname: Yagame
authors.forename: M
authors.initials: M
authors.lastname: Endoh
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
authors.forename: H
authors.initials: H
authors.lastname: Sakai
mesh_terms: D000328:Adult; D000799:Angioedema / Q000150:complications*; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D006801:Humans