title: Pre-clinical experimental studies of indomethacin-releasing copper intrauterine device.
abstract: Effects of two types of intrauterine device (IUD) on the prostaglandins and endothelin (ET) in uterus and on the endometrial morphology in rats and rabbits, and Cu2+ releasing amounts of both IUDs in vitro were observed. The results showed that the inhibiting action of the indomethacin-releasing copper IUD (FICu-IUD) on the PGI2 was stronger than that on the TXA2, the ratio of 6-keto-PGF1 alpha/TXB2 was reduced with the increase of the doses. There were significant differences between the groups. The FICu-IUD could inhibit the rising of the ET level and lighten the endometrial impairment caused by the FCu-IUD, and promote copper ion release. It was suggested that indomethacin released by FICu-IUD could effectively reduce abnormal uterine bleeding.
authors.affiliation: Family Planning Research Institute, Tongji Medical University, Wuhan 430030.
authors.forename: L
authors.initials: L
authors.lastname: Cao
authors.forename: Y
authors.initials: Y
authors.lastname: Zhou
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
authors.forename: Q
authors.initials: Q
authors.lastname: Du
authors.forename: W
authors.initials: W
authors.lastname: Li
authors.forename: Y
authors.initials: Y
authors.lastname: Hu
authors.forename: W
authors.initials: W
authors.lastname: Li
mesh_terms: D000818:Animals; D003300:Copper / Q000378:metabolism; D004717:Endometrium / Q000378:metabolism / Q000473:pathology; D019332:Endothelin-1 / Q000378:metabolism; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage*; D007435:Intrauterine Devices, Copper; D011453:Prostaglandins / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D019332:Endothelin-1; D011453:Prostaglandins; D003300:Copper; D007213:Indomethacin