Benzodiazepines and anticonvulsants for social phobia (social anxiety disorder).
Both benzodiazepines and conventional anticonvulsants have been evaluated as treatments for social phobia (social anxiety disorder). Among the benzodiazepines, clonazepam is the best studied, although there is reason to expect that all benzodiazepine anxiolytics would be effective for this condition. Among the anticonvulsants, gabapentin and pregabalin, an analogue of gamma-aminobutyric acid (GABA), have been shown to be more effective than placebo in double-blind studies. Other than a small negative open study of valproic acid for social phobia, there is a paucity of information on whether other anticonvulsants might be useful for this condition.
Jefferson
J W
JW
Madison Institute of Medicine, Inc., and the University of Wisconsin Medical School, USA. JeffJ@healthtechsys.com
D000085:Acetates / Q000627:therapeutic use; D000525:Alprazolam / Q000627:therapeutic use; D000588:Amines; D000927:Anticonvulsants / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D002998:Clonazepam / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids; D005500:Follow-Up Studies; D000077206:Gabapentin; D006801:Humans; D010698:Phobic Disorders / Q000188:drug therapy* / Q000523:psychology; D010919:Placebos; D000069583:Pregabalin; D016896:Treatment Outcome; D014635:Valproic Acid / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D010919:Placebos; D001569:Benzodiazepines; D000069583:Pregabalin; D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D014635:Valproic Acid; D000077206:Gabapentin; D000525:Alprazolam