[Acute toxicity of bemithyl and bromithyl].
The experiments on rats showed for bemithyl LD50 = 581.48 (350.17-965.57) mg/kg and for bromithyl LD50 = 1750.30 (1463.07-2093.92) mg/kg (males) and 1584.29 (1280.46-1960.22) mg/kg (females). The therapeutic ratios are 4-6 for both drugs, while the toxicity index is 10-15 for bemithyl and 20 <196> 22 for bromithyl. It was established that ergotropic effects prevail in the toxicity of bemithyl administered in the 20-80 mg/kg dose range, while trophotropic effects are dominating at doses above 100 mg/kg. Bromithyl exhibits a dose-dependent trophotropic effect in the entire dose range.
Bugaeva
L I
LI
Pharmacology Department, Institute of Pharmacology, Volgograd State Medical Academy, Ministry of Public Health of the Russian Federation, pl. Pavshikh Bortsov 1a, Volgograd, 400066 Russia.
Spasov
A A
AA
Verovskiĭ
V E
VE
Iezhitsa
I N
IN
D000547:Amantadine / Q000031:analogs & derivatives* / Q000633:toxicity*; D000818:Animals; D001562:Benzimidazoles / Q000633:toxicity*; D004338:Drug Combinations; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D023382:Toxicity Tests, Acute
D001562:Benzimidazoles; D004338:Drug Combinations; C049825:bemethyl; D000547:Amantadine; C085955:bromantane
Issledovanie ostroĭ toksichnosti bemitila i bromitila.