[Effect of the transcranial electrical stimulation of the endorphinergic brain structures on the functional activity of hepatocytes after toxic exposure].
Biochemical events of the rat hepatocytes cytolysis and deterioration of their synthetic activity and detoxification ability, as well as morphological events of lipid degeneration after acute poisoning with dichloretane and CCl4, were significantly reduced by effects of transcranial stimulation (TES). Blockade of the TES effects with naloxone revealed its endorphinergic nature. Combined effects of the TES and Essenciale preparation were lower than separate those of these agents. The TES effects were clinically corroborated in treatment of toxic hepatitis.
Lebedev
V P
VP
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Melikhova
M V
MV
Kolbasov
S E
SE
Stroĭkova
G V
GV
Zamuruev
O N
ON
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D004558:Electric Stimulation; D004723:Endorphins / Q000378:metabolism*; D005025:Ethylene Dichlorides; D005234:Fatty Liver / Q000473:pathology; D022781:Hepatocytes / Q000378:metabolism* / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D020011:Protective Agents / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D004723:Endorphins; D005025:Ethylene Dichlorides; D009292:Narcotic Antagonists; D010713:Phosphatidylcholines; D020011:Protective Agents; C011246:essential 303 forte; D009270:Naloxone; C024565:ethylene dichloride
Vliianie transkranial'noĭ élektrostimuliatsii éndorfinnykh struktur mozga krys na funktsional'nuiu aktivnost' gepatotsitov pri ikh toksicheskom povrezhdenii.