Effect of the aqueous extract of Rumex patientia on xylol and hyaluronidase induced capillary permeability compared to indomethacin.
In this study, the effect of an aqueous extract of Rumex patientia L. (Polygonaceae) (D-1) on capillary permeability which was induced by xylol and hyaluronidase was investigated. Experiments were conducted on rabbits according to Monakova and Matusis methods. The effects of D-1 were compared to those of indomethacin, which was used as a control throughout the experiment. Both D-1 (100 mg/kg) and indomethacin (10 mg/kg) were administered orally. As a result, D-1 inhibited capillary permeability, which was induced by xylol and hyaluronidase, and it was found that it was as effective as indomethacin.
Süleyman
H
H
Department of Pharmacology, Faculty of Medicine, Atatürk University, Erzurum, Turkey.
Demirezer
L O
LO
Kuruüzüm
A
A
Büyükokuroğlu
M E
ME
Gŏçer
F
F
Banoğlu
Z N
ZN
Gepdiremen
A
A
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D019664:Polygonaceae / Q000737:chemistry*; D011817:Rabbits; D014992:Xylenes / Q000494:pharmacology*
D010936:Plant Extracts; D014992:Xylenes; D006821:Hyaluronoglucosaminidase; C026114:2-xylene