title: Contribution of diminished ovarian reserve to hypofertility associated with endometriosis.
abstract: OBJECTIVE
  To determine if ovarian reserve, as measured by day 3 levels of E2 and FSH, was different in patients with endometriosis as compared to controls.
  
  
  METHODS
  Case-control study of 75 women with laparoscopically staged endometriosis and 75 age-matched controls undergoing in vitro fertilization/embryo transfer for male factor infertility.
  
  
  RESULTS
  In women with stage III/IV endometriosis (revised American Fertility Society staging), day 3 E2 and FSH levels were significantly higher than control levels (51.9 pg/mL and 12.6 mIU/mL versus 34.7 pg/mL and 9.7 mIU/mL, P < .03). In contrast, women with stage I/II endometriosis did not differ significantly when compared to controls (36.8 pg/mL and 10.4 mIU/mL versus 34.0 pg/mL and 10.2 mIU/mL). The total group showed significantly higher E2 levels (41.8 pg/mL versus 34.1 pg/mL, P < .03), but no significant differences in FSH levels were observed.
  
  
  CONCLUSIONS
  These data show that women with stage III/IV endometriosis have relatively diminished ovarian reserve, while this situation is not noted in women with stage I/II endometriosis. This observation is consistent with progressive loss of ovarian reserve in women with increasing stages of endometriosis independent of age.
authors.affiliation: Department of Obstetrics, Gynecology and Reproductive Sciences, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Hock
authors.forename: K
authors.initials: K
authors.lastname: Sharafi
authors.forename: L
authors.initials: L
authors.lastname: Dagostino
authors.forename: E
authors.initials: E
authors.lastname: Kemmann
authors.forename: D B
authors.initials: DB
authors.lastname: Seifer
mesh_terms: D016022:Case-Control Studies; D004624:Embryo Transfer; D004715:Endometriosis / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000209:etiology*; D007248:Infertility, Male / Q000628:therapy; D008297:Male; D010053:Ovary / Q000503:physiopathology*
chemical_list: D004958:Estradiol; D005640:Follicle Stimulating Hormone