title: Bovine mastitis therapy and why it fails.
abstract: Treatment of bovine mastitis depends on the cause, the clinical manifestation and the antibiotic susceptibility of the agent. Mastitis therapy is commonly unsuccessful owing to pathological changes that occur in the udder parenchyma as a result of the inflammatory reaction to mastitogenic bacteria, pharmacokinetic properties of antimicrobial mastitis drugs, mastitogenic bacterial and related factors, and poor animal husbandry and veterinary interventions.
authors.affiliation: Technology Transfer Division, ARC-Onderstepoort Veterinary Institute, South Africa.
authors.forename: J H
authors.initials: JH
authors.lastname: du Preez
mesh_terms: D000822:Animal Husbandry; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002417:Cattle; D005260:Female; D008321:Mammary Glands, Animal / Q000382:microbiology / Q000503:physiopathology*; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000517:prevention & control; D011322:Primary Prevention; D017211:Treatment Failure
chemical_list: D000900:Anti-Bacterial Agents