title: Motion adaptive x-ray therapy: a feasibility study.
abstract: Intrafraction motion caused by breathing requires increased treatment margins for chest and abdominal radiotherapy and may lead to 'motion artefacts' in dose distributions during intensity modulated radiotherapy (IMRT). Technologies such as gated radiotherapy may significantly increase the treatment time, while breath-hold techniques may be poorly tolerated by pulmonarily compromised patients. A solution that allows reduced margins and dose distribution artefacts, without compromising delivery time, is to synchronously follow the target motion by adapting the x-ray beam using a dynamic multileaf collimator (MLC), i.e. motion adaptive x-ray therapy, or MAX-T for short. Though the target is moving with time, in the MAX-T beam view the target is static. The MAX-T method superimposes the target motion due to respiration onto the beam originally planned for delivery. Thus during beam delivery the beam is dynamically changing position with respect to the isocentre using a dynamic MLC, the leaf positions of which are dependent upon the target position. Synchronization of the MLC motion and target motion occurs using respiration gated radiotherapy equipment. The concept and feasibility of MAX-T and the capability of the treatment machine to deliver such a treatment were investigated by performing measurements for uniform and IMRT fields using a mechanical sinusoidal oscillator to simulate target motion. Target dose measurements obtained using MAX-T for a moving target were found to be equivalent to those delivered to a static target by a static beam.
authors.affiliation: Department of Radiation Oncology, Medical College of Virginia Hospitals at Virginia Commonwealth University, Richmond, USA. pjkeall@vcu.edu
authors.forename: P J
authors.initials: PJ
authors.lastname: Keall
authors.forename: V R
authors.initials: VR
authors.lastname: Kini
authors.forename: S S
authors.initials: SS
authors.lastname: Vedam
authors.forename: R
authors.initials: R
authors.lastname: Mohan
mesh_terms: D005240:Feasibility Studies; D006801:Humans; D011874:Radiometry; D020266:Radiotherapy, Conformal / Q000295:instrumentation* / Q000379:methods*; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods; D014965:X-Rays