title: [Fibronectin as a diagnostic marker in several determined neurological diseases].
abstract: OBJECTIVE
  To determinate if fibronectin in CSF can be a useful parameter in the diagnosis of some neurologic illnesses.
  
  
  METHODS
  We have studied 30 patients, subdivided in four groups, depending on the type of neurologic illness. We have chosen as control a 10-patient group, which came to the Emergency Service and were diagnosed as a suspicious of neurologic illness, but after this it was discarded. In the whole group we practiced a lumbar puncture, with cytology, systematic, biochemistry, cultures, immunoglobulins determination and fibronectin quantification by ELISA.
  
  
  RESULTS
  We want to emphasize the increase in fibronectin levels in CSF in both the patients with bacterial meningitis and the multiple sclerosis groups, when it's compared with the control group.
  
  
  CONCLUSIONS
  For this, the determination of fibronectin levels in CSF might be a useful parameter in the diagnosis of some neurologic illnesses.
authors.affiliation: Servicio de Medicina Interna, Hospital Universitario, Valladolid.
authors.forename: L C
authors.initials: LC
authors.lastname: Merino García
authors.forename: E
authors.initials: E
authors.lastname: González Sarmiento
authors.forename: M C
authors.initials: MC
authors.lastname: Rubio del Val
authors.forename: P
authors.initials: P
authors.lastname: Ergueta Martín
authors.forename: M C
authors.initials: MC
authors.lastname: Hinojosa Mena-Bernal
authors.forename: I
authors.initials: I
authors.lastname: Fernández Martínez
authors.forename: A
authors.initials: A
authors.lastname: Marañón Cabello
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000134:cerebrospinal fluid; D015415:Biomarkers / Q000134:cerebrospinal fluid*; D016022:Case-Control Studies; D005353:Fibronectins / Q000134:cerebrospinal fluid*; D006801:Humans; D016920:Meningitis, Bacterial / Q000134:cerebrospinal fluid; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000175:diagnosis; D009422:Nervous System Diseases / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D011559:Pseudotumor Cerebri / Q000134:cerebrospinal fluid
chemical_list: D015415:Biomarkers; D005353:Fibronectins
vernacular_title: Fibronectina como marcador diagnóstico de determinadas enfermedades neurológicas.