title: Effect of white wine on esophageal peristalsis and acid clearance.
abstract: BACKGROUND
  In a previous study it was demonstrated that white wine reduces the lower esophageal sphincter pressure and induces gastroesophageal reflux characterized by reflux episodes of long duration. In the present study, it was evaluated whether wine disturbs esophageal peristalsis and acid clearance.
  
  
  METHODS
  Twelve healthy volunteers (7F, 23-37 years) received 300 ml white wine (8% vol/vol; WW), an ethanol solution (8% vol/vol; ET) or tap water (WA) together with a standardized meal in a random order. Acid clearance was tested by instillation of 15 ml 0.1 N HCI into the distal esophagus. The number of swallows (dry swallow every 30 sec) were counted until pH rose again above 5. Five wet swallows (5 ml) were applied to test primary peristalsis and five insufflations of 20 ml of air were performed to test secondary peristalsis. Each test was done immediately after and 60 min after ingestion of the beverages.
  
  
  RESULTS
  A significantly higher number of swallows were needed to clear the esophagus immediately after ingestion of wine (P < 0.01; median number: WW 12; ET 8; WA 7) due to an increase in the frequency of failed, simultaneous, and low-amplitude contractions. The frequency of triggered secondary contractions was decreased (P < 0.02; WW 70%; ET 100%; WA 100%) and the latency between air injection and onset of secondary peristalsis was prolonged (P < 0.05; WW 9 sec; ET 7 sec; WA 6 sec) immediately after ingestion of white wine. Wet swallow induced primary peristalsis was not influenced by wine. No significant differences in the measured parameters were seen 60 min after ingestion of the three beverages.
  
  
  CONCLUSIONS
  White wine disturbs temporarily esophageal clearance due to a disturbance of triggering secondary peristalsis and due to an increase in ineffective contractions. The ethanol content alone is not responsible for the effects of white wine on esophageal peristalsis and acid clearance.
authors.affiliation: Dept of Gastroenterology, Academic Teaching Hospital Munich-Bogenhausen, Munich, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Pehl
authors.forename: M
authors.initials: M
authors.lastname: Frommherz
authors.forename: B
authors.initials: B
authors.lastname: Wendl
authors.forename: T
authors.initials: T
authors.lastname: Schmidt
authors.forename: A
authors.initials: A
authors.lastname: Pfeiffer
mesh_terms: D000328:Adult; D004947:Esophagus / Q000502:physiology*; D005260:Female; D005744:Gastric Acid; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D010528:Peristalsis; D014920:Wine