[Two cases of episodic angioedema associated with eosinophilia].
We experienced two cases of limb edema of unknown pathogenesis. No evidence was found concerning involvement of the kidneys, heart of other visceral organs. Case 1 was 22-year-old woman. Her white blood cell count increased to 13,100/microliter with 65.0% eosinophils. Case 2 was a 27-year-old woman. Her white blood cell count increased to 23,300/microliter with 67.0% eosinophils. In these cases, extensive diagnostic evaluations revealed no evidence of atopy, neoplasms, collagen-vascular disease, or parasitic infestation. We diagnosed these cases as episodic angioedema with eosinophilia. In both cases, the angioedema improved gradually in parallel with a decrease in the white blood cell count. This disorder is very rare, but it is very important to consider it in differential diagnosis especially for nephrologists.
Toyoda
M
M
Division of Nephrology and Metabolism, School of Medicine, Tokai University, Kanagawa, Japan.
Suzuki
D
D
Uehara
G
G
Umezono
T
T
Horiki
T
T
Yagame
M
M
Endoh
M
M
Kurokawa
K
K
Sakai
H
H
D000328:Adult; D000799:Angioedema / Q000150:complications*; D004802:Eosinophilia / Q000150:complications*; D005260:Female; D006801:Humans