title: Basal expression of bradykinin B1 receptor in peripheral sensory ganglia in the rat.
abstract: The bradykinin B1 receptor is thought to be induced by tissue injury and inflammation. In the present study, we have investigated whether there is a basal expression of B1 receptor in dorsal root ganglion (DRG) and trigeminal ganglion neurons in rats. A substantial number of neurons in both DRGs and trigeminal ganglia were found to be B1-immunoreactive in rats. Both small and medium-sized DRG neurons were B1-immunoreactive, suggesting that they are likely to be Adelta- or C-fibre neurons which are involved in nociceptive transmission. These results support a possible role for B1 receptors in the modulation of nociceptive sensory transmission.
authors.affiliation: Department of Pharmacology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Harlow, UK.
authors.forename: Q P
authors.initials: QP
authors.lastname: Ma
authors.forename: R
authors.initials: R
authors.lastname: Hill
authors.forename: D
authors.initials: D
authors.lastname: Sirinathsinghji
mesh_terms: D000818:Animals; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000502:physiology; D009475:Neurons, Afferent / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin / Q000378:metabolism*; D012668:Trigeminal Ganglion / Q000166:cytology / Q000378:metabolism*
chemical_list: D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin