Homeostasis model assessment is a reliable indicator of insulin resistance during follow-up of patients with type 2 diabetes.
OBJECTIVE
To investigate the usefulness of the homeostasis model assessment as an index of insulin resistance (HOMA-IR) for evaluating the clinical course of patients with type 2 diabetes.


METHODS
The usefulness of HOMA-IR and its relationship with insulin resistance assessed by the hyperinsulinemic-euglycemic clamp study (clamp IR) were evaluated in 55 Japanese patients with type 2 diabetes before and after treatment. The patients were subjected to diet (approximately 1,440-1,720 kcal/day) and exercise therapy (walking 10,000 steps daily) for 6 weeks during their hospitalization.


RESULTS
Univariate regression analysis disclosed a significant correlation between log-transformed HOMA-IR and log-transformed clamp IR before (r = -0.613, P < 0.0001) and after ( = -0.734, P < 0.0001) treatment. Neither the slopes (-0.71 +/- 0.12 vs. -0.79 +/- 0.09, F = 0.25, P = 0.61) nor the intercepts (y-intercept = 1.67 vs. 1.70, x-intercept = 2.36 vs. 2.15, F = 0.02, P = 0.88) of the regression lines between HOMA-IR and clamp IR were significantly different before and after treatment. There was a significant correlation between the decrease in log-transformed HOMA-IR and the increase in clamp IR during treatment (r = -0.617, P < 0.0001).


CONCLUSIONS
HOMA-IR may constitute a useful method not only for diagnosing insulin resistance, but also for follow-up during the treatment of patients with type 2 diabetes.
Katsuki
A
A
Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan. katukia@clin.medic.mie-u.ac.jp
Sumida
Y
Y
Gabazza
E C
EC
Murashima
S
S
Furuta
M
M
Araki-Sasaki
R
R
Hori
Y
Y
Yano
Y
Y
Adachi
Y
Y
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000628:therapy; D004032:Diet; D015444:Exercise; D005215:Fasting; D005260:Female; D015309:Glucose Clamp Technique; D006442:Glycated Hemoglobin / Q000032:analysis; D006706:Homeostasis; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D012044:Regression Analysis
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin