title: Initial clinical experience with the selective phosphodiesterase-I isoenzyme inhibitor vinpocetine in the treatment of urge incontinence and low compliance bladder.
abstract: Current pharmacological treatment modalities for urge incontinence and low compliance bladder are limited by a low clinical efficacy and the significant side effects of the standard drugs available. Previous in vitro studies indicated a possible functional relevance of the intracellular phosphodiesterase (PDE)-1 isoenzyme in the regulation of human detrusor smooth muscle contractility. We therefore investigated the effect of the PDE-1 inhibitor vinpocetine in nonresponders to standard pharmacological therapy. In 11/19 patients (57.9%) clinical symptoms and/or urodynamic parameters were improved. Although these initial data are preliminary, they represent the first evidence that isoenzyme-selective PDE inhibition may be a novel approach to the treatment of lower urinary tract disorders.
authors.affiliation: Department of Urology, Medizinische Hochschule Hannover, Germany. truss.michael@mh-hannover.de
authors.forename: M C
authors.initials: MC
authors.lastname: Truss
authors.forename: C G
authors.initials: CG
authors.lastname: Stief
authors.forename: S
authors.initials: S
authors.lastname: Uckert
authors.forename: A J
authors.initials: AJ
authors.lastname: Becker
authors.forename: D
authors.initials: D
authors.lastname: Schultheiss
authors.forename: S
authors.initials: S
authors.lastname: Machtens
authors.forename: U
authors.initials: U
authors.lastname: Jonas
mesh_terms: D003187:Compliance; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D010727:Phosphoric Diester Hydrolases / Q000187:drug effects*; D010865:Pilot Projects; D001743:Urinary Bladder / Q000503:physiopathology; D001745:Urinary Bladder Diseases / Q000188:drug therapy* / Q000503:physiopathology; D014549:Urinary Incontinence / Q000188:drug therapy* / Q000503:physiopathology; D014563:Urodynamics; D014748:Vinca Alkaloids / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D007527:Isoenzymes; D010726:Phosphodiesterase Inhibitors; D014748:Vinca Alkaloids; C013983:vinpocetine; D010727:Phosphoric Diester Hydrolases