title: The antibacterial effect of topical anesthetic proparacaine on conjunctival flora.
abstract: OBJECTIVE
  To investigate the antibacterial effect of topical anesthetic proparacaine on conjunctival flora.
  
  
  METHODS
  One hundred and forty-four eyes of 72 patients awaiting cataract surgery were included in the study. A commercially available solution of proparacaine, preserved with benzalkonium chloride 0.01%, was instilled in one eye of all subjects while the vehicle solution, including the same concentration of preservative in aqueous solution, was administered to the other eye. Conjunctival cultures were taken from all eyes before and 15 minutes after the instillation of proparacaine and the vehicle.
  
  
  RESULTS
  Of the 144 eyes, 76 (52.8%) had positive-conjunctival cultures with the most commonly isolated organisms being coagulase-negative staphylococci in each group. Of the 76 culture-positive eyes, 40 (52.6%) received proparacaine and 36 (47.4%) the vehicle preparation. Fifteen minutes after the instillation of proparacaine and the vehicle eyedrops, four eyes (10%) and 12 eyes (33.3%) had culture-positive conjunctival smears, respectively. Proparacaine significantly reduced the number of culture-positive eyes (p = 0.0003), in contrast to the vehicle (p = 0.21).
  
  
  CONCLUSIONS
  A topical anesthetic, proparacaine, demonstrates antibacterial effects on the conjunctival flora.
authors.affiliation: Department of Ophthalmology, Harran University School of Medicine, Sanliurfa, Turkey. halitoguz@hotmail.com
authors.forename: H
authors.initials: H
authors.lastname: Oguz
authors.forename: E
authors.initials: E
authors.lastname: Oguz
authors.forename: S
authors.initials: S
authors.lastname: Karadede
authors.forename: G
authors.initials: G
authors.lastname: Aslan
mesh_terms: D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage*; D002387:Cataract Extraction / Q000009:adverse effects; D003228:Conjunctiva / Q000382:microbiology*; D015818:Eye Infections, Bacterial / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007536:Isomerism; D008297:Male; D008875:Middle Aged; D011430:Propoxycaine / Q000008:administration & dosage*; D011446:Prospective Studies; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D013210:Staphylococcus / Q000187:drug effects / Q000302:isolation & purification*; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D000779:Anesthetics, Local; C005717:proxymetacaine; D011430:Propoxycaine