Hydraphile channels: models for transmembrane, cation-conducting transporters.
A completely synthetic, non-peptide channel has been prepared and shown to conduct cations across a phospholipid bilayer membrane. Studies have been undertaken to assess the compound's location within the bilayer and to better understand its function. These studies are described along with background on the design and concept of the channel.
Gokel
G W
GW
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA. ggokel@molecool.wustl.edu
Ferdani
R
R
Liu
J
J
Pajewski
R
R
Shabany
H
H
Uetrecht
P
P
D002412:Cations / Q000378:metabolism*; D003619:Dansyl Compounds / Q000737:chemistry; D005453:Fluorescence; D007202:Indicators and Reagents / Q000737:chemistry; D007473:Ion Channels / Q000138:chemical synthesis* / Q000378:metabolism; D017136:Ion Transport; D008051:Lipid Bilayers / Q000737:chemistry / Q000378:metabolism*; D008956:Models, Chemical; D015394:Molecular Structure
D002412:Cations; D003619:Dansyl Compounds; D007202:Indicators and Reagents; D007473:Ion Channels; D008051:Lipid Bilayers