Stability and bioavailability of antioxidants in garland (Chrysanthemum coronarium L.).
The stability and bioavailability of the major antioxidants in garland (Chrysanthemum coronarium L.), chlorogenic acid, 3,5-dicaffeoylquinic acid and 4-succinyl-3,5-dicaffeoylquinic acid, were investigated together with caffeic acid. These compounds were stable in artificial digestive juice, but more than 90% of them disappeared from plasma within 30 min after intravenous injection into rats. When they were orally administered, only caffeic acid could be detected.
Takenaka
M
M
National Food Research Institute, Ministry of Agriculture, Forestry, and Fisheries, Tsukuba, Ibaraki, Japan. tknk1221@nfri.affrc.go.jp
Nagata
T
T
Yoshida
M
M
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000737:chemistry / Q000493:pharmacokinetics*; D001682:Biological Availability; D002109:Caffeic Acids / Q000737:chemistry / Q000493:pharmacokinetics; D002726:Chlorogenic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D011723:Chrysanthemum cinerariifolium / Q000737:chemistry; D004355:Drug Stability; D005750:Gastric Juice / Q000502:physiology; D007275:Injections, Intravenous; D008297:Male; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley
C425562:4-succinyl-3,5-dicaffeoylquinic acid; D000975:Antioxidants; D002109:Caffeic Acids; D011801:Quinic Acid; D002726:Chlorogenic Acid; C100434:3,5-dicaffeoylquinic acid; C040048:caffeic acid