Immunoprophylaxis against Mycobacterium leprae infection with subunit vaccines.
We have investigated the effect of subunit vaccines against infection with Mycobacterium leprae, employing DNA plasmids as the vaccine vectors, and the immunodominant 35 kDa protein of M. leprae as the candidate antigen. A DNA vaccine that expresses the M. leprae 35 kDa protein both stimulated interferon-gamma (IFN gamma)-secreting T cells in mice, and demonstrated protection against M. leprae-infection of mice.
Britton
W J
WJ
Mycobacterial Research Group, Centenary Institute for Cancer Medicine & Cell Biology, Locked Bag No 6, Newtown, 2042, New South Wales, Australia.
Martin
E
E
Kamath
A T
AT
Neupane
K D
KD
Roche
P W
PW
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D004195:Disease Models, Animal; D007918:Leprosy / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D012680:Sensitivity and Specificity; D022223:Vaccines, Subunit / Q000008:administration & dosage
D001428:Bacterial Vaccines; D022223:Vaccines, Subunit; C060596:anti-leprosy vaccine