Impaired autonomic control of the heart by SOX10 mutation.
The autonomic nervous system plays an important role in the generation of complex heart rate dynamics that enable an organism to adapt to stress. Little is known about genes influencing the development of this autonomic control of the heart. We suggest the SOX10 gene to be a candidate for this process.
Korsch
E
E
Steinkuhle
J
J
Massin
M
M
Lyonnet
S
S
Touraine
R L
RL
D000293:Adolescent; D001341:Autonomic Nervous System / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000235:genetics*; D006339:Heart Rate / Q000502:physiology*; D006609:High Mobility Group Proteins / Q000235:genetics*; D006801:Humans; D009154:Mutation; D055757:SOXE Transcription Factors; D014157:Transcription Factors; D014849:Waardenburg Syndrome / Q000235:genetics* / Q000503:physiopathology*
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; C527923:SOX10 protein, human; D055757:SOXE Transcription Factors; D014157:Transcription Factors