title: [Evaluation of late radiation-induced changes in superficial microcirculation. I. Clinical benefit of the cutaneous Doppler laser].
abstract: OBJECTIVE
  The changes that occur in the tissular microcirculation after therapeutic irradiation (RT) account for some of the late effects of irradiation, especially on the cutaneous level. As a rule, the methods of exploring the superficial microcirculation only measure blood flow indirectly. Only the Doppler laser can provide direct measurements of blood parameters in vivo in man.
  
  
  METHODS
  Thirty women who had been irradiated with 45 + 20 Gy of locoregional fractionated adjuvant RT for breast cancer developed local radiation-induced fibrosis six years later (+/- 5). The local microcirculation was measured in the resting state and during thermal stimulation at 42 degrees C, using a Periflux cutaneous Doppler laser with p413 probes. Three periods of six minutes each were continuously recorded: period 1 (P1) represented basal resting cutaneous perfusion, with the slope p corresponding to the increase in perfusion when two minutes of thermal stimulation at 42 degrees C began; P2 to plateau perfusion during this stimulation; and P3 to perfusion on the return to equilibrium. Each individual was its own control.
  
  
  RESULTS
  In the women treated by RT, the resting microcirculation in the skin underlying an area of late fibrosis rose by a factor of 2 during P1 (p < 0.001), and the P2/P1 ratio decreased by a factor of 2 (p < 0.001), compared to the control area. After thermal stimulation, there was no change in p, P2 or P3.
  
  
  CONCLUSIONS
  Although a hypovascularization is frequently found in late sequelae of RT, we observed an increase of the cutaneous microcirculation associated with a maladjustment of the endothelial response to a thermal stimulation. These observations seem to reflect the presence of dilated new capillaries of the telangiectatic type, which are macroscopically undetectable.
authors.affiliation: Service d'oncologie-radiothérapie, hôpital Saint-Louis, 10, avenue Claude-Vellefaux, 75010 Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Delanian
authors.forename: J L
authors.initials: JL
authors.lastname: Lefaix
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced; D017078:Laser-Doppler Flowmetry; D008833:Microcirculation; D008875:Middle Aged; D017564:Radiation Pneumonitis; D011878:Radiotherapy / Q000009:adverse effects*; D012867:Skin / Q000098:blood supply* / Q000473:pathology
vernacular_title: Evaluation des modifications radio-induites tardives de la microcirculation superficielle. I. Apport clinique du laser doppler cutané.