title: Neonatal meningitis in England and Wales: 10 years on.
abstract: OBJECTIVE
  To determine the incidence of neonatal meningitis in England and Wales.
  
  
  METHODS
  A national postal survey using the British Paediatric Surveillance Unit (BPSU) card scheme supplemented by information from other sources.
  
  
  METHODS
  England and Wales 1996-1997.
  
  
  METHODS
  A total of 274 babies less than 28 days of age who were treated for meningitis.
  
  
  RESULTS
  The incidence of neonatal meningitis in England and Wales has not changed since our previous study in 1985-1987. However, the acute phase mortality has fallen from 19.8% in 1985-1987 to 6.6% in this study. Group B streptococci (42%) and Escherichia coli (16%) remain the most common infecting microorganisms. Eight of 69 (12%) babies with group B streptococci and 4/26 (15%) with E coli died. Antibiotic regimens based on the third generation cephalosporins, notably cefotaxime, were most commonly used (84%). The BPSU scheme identified 72% of cases during the study period. Most cases of viral meningitis were not reported through the BPSU. Less than a third of samples from aseptic meningitis were examined for viruses; 56% of these were positive.
  
  
  CONCLUSIONS
  Although the incidence of neonatal meningitis remains unchanged, mortality from this infection has fallen significantly. If this improvement is maintained as reflected in the level of sequelae at 5 years of age, then the fear surrounding meningitis during the neonatal period will have been dramatically reduced.
authors.affiliation: The Karim Centre for Meningitis Research, Imperial College School of Medicine, Department of Paediatrics and Neonatal Medicine, Queen Charlotte's and Chelsea Hospital, Goldhawk Road, London W6 0XG, UK.
authors.forename: D E
authors.initials: DE
authors.lastname: Holt
authors.forename: S
authors.initials: S
authors.lastname: Halket
authors.forename: J
authors.initials: J
authors.lastname: de Louvois
authors.forename: D
authors.initials: D
authors.lastname: Harvey
mesh_terms: D000890:Anti-Infective Agents / Q000627:therapeutic use; D001724:Birth Weight; D004352:Drug Resistance, Microbial; D004739:England / Q000453:epidemiology; D005260:Female; D005865:Gestational Age; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D016920:Meningitis, Bacterial / Q000188:drug therapy / Q000453:epidemiology*; D016921:Meningitis, Fungal / Q000188:drug therapy / Q000453:epidemiology*; D008587:Meningitis, Viral / Q000188:drug therapy / Q000453:epidemiology*; D012307:Risk Factors; D015996:Survival Rate; D014852:Wales / Q000453:epidemiology
chemical_list: D000890:Anti-Infective Agents