title: Cerebral blood flow alterations in progressive communicating hydrocephalus: transcranial Doppler ultrasonography assessment in an experimental model.
abstract: OBJECTIVE
  In many cases communicating hydrocephalus is the result of impairments in cerebrospinal fluid absorption in the arachnoid villi at the cranial convexity. Reported methods of creating experimental hydrocephalus have not sought to produce an arachnoidal adhesion in the cranial convexity. In this study the authors investigate alterations in cerebral blood flow (CBF) in experimental communicating hydrocephalus induced by the injection of kaolin into the subarachnoid space at the convexity in neonatal rats.
  
  
  METHODS
  In neonatal rats, kaolin was injected into the subarachnoid space at the cranial convexity. Assessment of CBF alterations was performed using transcranial Doppler ultrasonography preinjection and at 10 days, 4 weeks, and 8 weeks postinjection. Light microscopy examination was also performed at 4 weeks and 8 weeks postinjection. Conspicuous lateral ventricle enlargements of different dimensions were observed in kaolin-injected rats at 4 to 8 weeks postinjection. The third and fourth ventricles were dilated to a lesser extent. Resistance to CBF and increased mean CBF velocity were apparent 8 weeks after kaolin injection. Further, destruction and even loss of ependymal layers were more prominent at the chronic stage.
  
  
  CONCLUSIONS
  The present model may be considered a progressive communicating hydrocephalus because of marked changes in blood flow dynamics and destruction of the ependymal layer at the chronic stage.
authors.affiliation: Department of Neurosurgery, Osmangazi University, Eskisehir, Turkey. ecosan@ogu.edu.tr
authors.forename: T E
authors.initials: TE
authors.lastname: Cosan
authors.forename: D
authors.initials: D
authors.lastname: Gucuyener
authors.forename: E
authors.initials: E
authors.lastname: Dundar
authors.forename: A
authors.initials: A
authors.lastname: Arslantas
authors.forename: M
authors.initials: M
authors.lastname: Vural
authors.forename: K
authors.initials: K
authors.lastname: Uzuner
authors.forename: E
authors.initials: E
authors.lastname: Tel
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001783:Blood Flow Velocity / Q000502:physiology; D001921:Brain / Q000098:blood supply* / Q000473:pathology; D015170:Cerebrospinal Fluid Pressure / Q000502:physiology; D018450:Disease Progression; D004805:Ependyma / Q000473:pathology; D006801:Humans; D006849:Hydrocephalus / Q000000981:diagnostic imaging* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D017585:Ultrasonography, Doppler, Transcranial