title: Effect of fluconazole on agar invasion by Candida albicans.
abstract: Subinhibitory concentrations of azoles are known to inhibit hyphal branching of Candida albicans in liquid media. This study showed that subinhibitory concentrations of fluconazole also inhibit agar invasion by C. albicans in YPD solid medium. Agar invasion was markedly inhibited in two C. albicans strains that were resistant to fluconazole. This suggests that the degree to which fluconazole inhibits agar invasion by C. albicans hyphae could serve as a marker of susceptibility to azoles.
authors.affiliation: *Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
authors.forename: Dimitrios P
authors.initials: DP
authors.lastname: Kontoyiannis
authors.affiliation: *Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
authors.forename: Jeffrey
authors.initials: J
authors.lastname: Tarrand
authors.affiliation: *Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
authors.forename: Randall
authors.initials: R
authors.lastname: Prince
authors.affiliation: *Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
authors.forename: George
authors.initials: G
authors.lastname: Samonis
authors.affiliation: *Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
authors.forename: Kenneth V R
authors.initials: KVR
authors.lastname: Rolston
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development*; D002177:Candidiasis / Q000382:microbiology; D003470:Culture Media; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000592:standards
chemical_list: D000935:Antifungal Agents; D003470:Culture Media; D015725:Fluconazole