New variations in human OX40 ligand (CD134L) gene.
We found three new variations in the OX40 ligand (OX40L, CD134L) gene and its 5' upstream region. -921 (G-->A) at 5' upstream region, -19 (C-->G) at 5' untranslated region, and 202 + 25 (G-->T) at intron 2 were identified. -921 (G-->A) and 202 + 25 (G-->T) were detected in a substantial proportion of healthy Japanese individuals and were considered to be single nucleotide polymorphisms (SNPs). -19 (C-->G) was detected in only one healthy individual. There was no association between these variations and the presence of rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE).
Hikami
K
K
Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan 113-0033.
Tsuchiya
N
N
Tokunaga
K
K
D001172:Arthritis, Rheumatoid / Q000235:genetics; D001483:Base Sequence; D018076:DNA, Complementary; D014644:Genetic Variation; D006801:Humans; D008024:Ligands; D008180:Lupus Erythematosus, Systemic / Q000235:genetics; D008562:Membrane Glycoproteins; D008969:Molecular Sequence Data; D053278:OX40 Ligand; D020641:Polymorphism, Single Nucleotide; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics*
D018076:DNA, Complementary; D008024:Ligands; D008562:Membrane Glycoproteins; D053278:OX40 Ligand; D018124:Receptors, Tumor Necrosis Factor; C089251:TNFSF4 protein, human