An infant with homozygous hemoglobin D-Iran.
Hemoglobin D-Iran (Hb D-Iran, beta 22 Glu-->Gln) is a beta-chain variant that was first described in 1973. Hb D-Iran in combination with normal Hb A (Hb D-Iran trait) is a benign condition. Hb D-Iran has also been described in combination with sickle hemoglobin and beta thalassemia, but never as a homozygous mutation. The authors describe a case of homozygous Hb D-Iran in an infant of Pakistani descent. The hematologic values, hemoglobin electrophoresis, peripheral blood smear, and clinical course to date suggest that homozygous Hb D-Iran is a relatively benign condition with mild microcytic anemia, poikilocytosis, and minimal hemolysis.
Thornburg
C D
CD
Pediatric Residency Training Program, Department of Pediatrics, Duke University Medical Center, Durham, North Carolina 27710, USA.
Zimmerman
S A
SA
Schultz
W H
WH
Ware
R E
RE
D000740:Anemia / Q000097:blood / Q000235:genetics; D004913:Erythrocytes, Abnormal; D005319:Fetal Hemoglobin / Q000032:analysis; D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000235:genetics*; D006461:Hemolysis; D006720:Homozygote; D006801:Humans; D007223:Infant; D008297:Male; D009657:North Carolina; D010154:Pakistan / Q000208:ethnology
D006455:Hemoglobins, Abnormal; C073639:hemoglobin D Iran; D005319:Fetal Hemoglobin