Analgesic components of saposhnikovia root (Saposhnikovia divaricata).
By activity-oriented separation using the writhing method in mice, the analgesic components of Saposhnikovia root (Saposhnikovia divaricata Schischkin; Umbelliferae) were identified to be chromones, coumarins, polyacetylenes and 1-acylglycerols. Two new components, divaricatol and (3'S)-hydroxydeltoin, were also isolated. The most potent analgesia was observed in chromones such as divaricatol, ledebouriellol and hamaudol, which inhibited writhing inhibition at an oral dose of 1 mg/kg in mice. Acylglycerols also showed inhibition significantly at a dose of 5 mg/kg. In some pharmacological tests using sec-O-glucosylhamaudol, the compound showed analgesia by the tail pressure and the Randall & Selitto methods, and its writhing inhibition was not reversed by naloxone.
Okuyama
E
E
Faculty of Pharmaceutical Sciences, Chiba University, Japan. emi@p.chiba-u.ac.jp
Hasegawa
T
T
Matsushita
T
T
Fujimoto
H
H
Ishibashi
M
M
Yamazaki
M
M
D018712:Analgesics, Non-Narcotic / Q000737:chemistry / Q000302:isolation & purification*; D000818:Animals; D019661:Apiaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D013057:Spectrum Analysis
D018712:Analgesics, Non-Narcotic