Molecularly imprinted microparticles for capillary electrochromatographic enantiomer separation of propranolol.
Molecularly imprinted microparticles imprinted against (S)-propranolol were synthesised and studied for use in capillary electrochromatographic separation of propranolol enantiomers. The imprinted microparticles were in the size range of 0.2-0.5 micron as determined by scanning electron microscopy. The microparticles were suspended, in high concentration, in the electrolyte and used to perform enantiomer separation by a partial filling technique.
Schweitz
L
L
Technical Analytical Chemistry, Center for Chemistry and Chemical Engineering, Lund University, P O Box 124, SE-221 00 Lund, Sweden.
Spégel
P
P
Nilsson
S
S
D000319:Adrenergic beta-Antagonists / Q000032:analysis*; D020374:Chromatography, Micellar Electrokinetic Capillary / Q000379:methods; D007536:Isomerism; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011433:Propranolol / Q000032:analysis*
D000319:Adrenergic beta-Antagonists; D011433:Propranolol