[Mechanism of metabolic adaptation].
The paper presents results of investigations on some mechanisms of metabolic adaptation in mammals. There are four sections in the tissue metabolic system of acid-base homeostasis: polyamines as factors of metabolic adaptation; significance of carbon dioxide for metabolic response formation in hypobiosis; polyamines metabolism in hypobiosis. Peculiarities of intermediate metabolism have been analyzed in animal tissues under the changes in H+, CO2 and HCO3- concentrations. Basing on a new interpretation of the experimental data and detected regularity in the metabolism, conclusion on the existence of a new acid-base homeostasis system in the tissues has been made. The results of polyamines metabolism investigations in the mammals under the stress have been described. The experimental data make us to believe that changes in polyamines synthesis and ODC activity in particular, is a part of stereotype nonspecific response to any stress impacts and one of the factors of cell metabolic adaptation. Some new data on mechanisms of formation and control of metabolic status of animals in the natural and artificial hibernation have been presented. The key idea is that in the state of hypobiosis the carbon dioxide (HCO3-) appears as a regulatory factor of metabolic adaptation, which is able to realize its action directly via affecting numerous biochemical events. The participation of polyamines in adaptive metabolic response to hybernation factors is suggested. Some peculiarities of ornithine decarboxilase and transglutaminase activity during the different stages of genuine and artificial hypobiosis have been demonstrated.
Mel'nychuk
D O
DO
Palladin Institute of Biochemistry, NAS of Ukraine, Kyiv.
Mykhaĭlovskyĭ
V O
VO
Mel'nychuk
S D
SD
D000136:Acid-Base Equilibrium; D000222:Adaptation, Physiological; D015317:Biogenic Polyamines / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D008660:Metabolism / Q000502:physiology*
D015317:Biogenic Polyamines; D002245:Carbon Dioxide
Mekhanizmy metabolichnoï adaptatsiï.