Synthesis of 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues modified at the C-4 and C-9 positions and their behaviour towards sialidase from influenza virus and pig liver membrane.
The synthesis of novel 2-deoxy-2,3-didehydro-N-acetylneuraminic acid analogues structurally varied at C-4 and C-9 by transformation from versatile key intermediates and their inhibitory activity against sialidase from influenza virus A and pig liver membrane are described.
Ikeda
K
K
Department of Synthetic Organic Chemistry and Medicinal Chemistry, School of Pharmaceutical Sciences, University, Shizuoka, Japan. ikeda@ys2.u-shizuoka-ken.ac.jp
Sano
K
K
Ito
M
M
Saito
M
M
Hidari
K
K
Suzuki
T
T
Suzuki
Y
Y
Tanaka
K
K
D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis; D008099:Liver / Q000648:ultrastructure*; D019158:N-Acetylneuraminic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D009975:Orthomyxoviridae / Q000201:enzymology*; D013329:Structure-Activity Relationship; D013552:Swine
D004791:Enzyme Inhibitors; C036137:2-deoxy-2,3-dehydro-N-acetylneuraminic acid; D009439:Neuraminidase; D019158:N-Acetylneuraminic Acid