title: A novel single nucleotide polymorphism and five probable haplotypes in the 5' flanking region of the IL-6 gene in African-Americans.
abstract: In order to identify novel single nucleotide polymorphisms (SNPs), we sequenced a 940 bp region of the 5' flanking region of the IL-6 gene in 63 normal African-Americans. We identified a biallelic (G/C) SNP at position -573 relative to the transcription start site (-573C allele frequency 0.095). This SNP, together with SNPs at -598 and -174, allows identification of five probable haplotypes. Haplotypes containing the -174C allele, which has been associated with lower plasma IL-6 levels, were uncommon (4%). These haplotypes may influence IL-6 gene transcription and thus may contribute to racial differences in the prevalence of inflammatory diseases.
authors.affiliation: Division of Clinical Immunology and Rheumatology, University of Alabama at Birmingham, Birmingham, AL, USA.
authors.forename: M
authors.initials: M
authors.lastname: Osiri
authors.forename: J
authors.initials: J
authors.lastname: McNicholl
authors.forename: L W
authors.initials: LW
authors.lastname: Moreland
authors.forename: S L
authors.initials: SL
authors.lastname: Bridges
mesh_terms: D044383:Black People / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014481:United States; D001741:Black or African American
chemical_list: D015850:Interleukin-6