[The use of liposomal form of phenylimide of cis-aconitic acid in herpes therapy].
The results of study of the antiviral activity and pharmacokinetics of phenylimide of cis-aconitic acid (PCAA) is presented. The 20% increase of the antiviral activity of PCAA incorporated into liposomes in comparison with the antiviral activity of the pure substance was shown. Liposomes with PCAA were tropic to lymphocytes and macrophages with maximum fluorescence being observed in the spleen, while empty liposomes were accumulated mainly in the liver. After the treatment with liposomal PCAA the symptoms of herpetic meningoencephalitis became less severe with 100% survival of the experimental animals. In the control group of rabbits 50% of the animals died, and in the surviving animals blindness or paralysis developed.
Kuchma
I Iu
IIu
Mechnikov Research Institute of Microbiology and Immunology, Kharkov, Ukraine.
Volianskiĭ
A Iu
AIu
Moskalenko
V F
VF
Tkachuk
T V
TV
Dobroskok
A I
AI
Martynov
A V
AV
Smelianskaia
M V
MV
Peremot
S D
SD
D000156:Aconitic Acid / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D007094:Imides / Q000008:administration & dosage* / Q000493:pharmacokinetics; D016849:Keratitis, Herpetic / Q000188:drug therapy*; D008081:Liposomes; D011817:Rabbits; D013237:Stereoisomerism
D000998:Antiviral Agents; D007094:Imides; D008081:Liposomes; C432170:cis-aconitic acid phenylimide; D000156:Aconitic Acid
Primenenie fenilimida tsisakonitovoĭ kisloty v liposomal'noĭ forme dlia terapii gerpesa.