title: Effects of stent coating on platelets and endothelial cells after intracoronary stent implantation.
abstract: BACKGROUND
  Adhesion molecules are known to be important in the regulation of endothelial cell and platelet functions. Increased platelets P-selectin expression is a marker of stent thrombosis after uncoated stent placement.
  
  
  OBJECTIVE
  The aim of this study was to compare the effects of intracoronary placement of phosphorylcholine (PC)-coated, versus heparin-coated, versus uncoated stents on platelets and endothelial activity.
  
  
  METHODS
  Thirty patients (age 55 +/- 10, 27 men) with significant proximal left anterior descending coronary artery stenoses were randomized to elective implantation of PC-coated, versus heparin-coated, versus uncoated stents. Following stent placement, intravenous heparin and aspirin plus ticlopidine were administered. Venous plasma soluble E-selectin, sP-selectin, and intercellular adhesion molecule-l levels were measured before the procedure and 24 and 48 h thereafter as markers of platelet and endothelial cell activation. Patients were excluded if they had a disease known to influence platelet and endothelial cell function.
  
  
  RESULTS
  Plasma sP-selectin levels decreased significantly after implantation of PC- and heparin-coated stents (p = 0.04), but remained unchanged in patients randomized to uncoated stents. Plasma sE-selectin levels increased significantly after uncoated stent placement (p = 0.04) and remained unchanged after coated stent implantation.
  
  
  CONCLUSIONS
  In patients treated with combined antiplatelet therapy, implantation of PC- and heparin-coated stents decreased platelet activity without activating endothelial cells, whereas placement of uncoated stents led to endothelial activation without changing platelet activity. These results suggest that PC-coated and heparin-coated stents may be advantageous in limiting thrombotic complications.
authors.affiliation: Hacettepe University Faculty of Medicine, Department of Cardiology, Ankara, Turkey.
authors.forename: E
authors.initials: E
authors.lastname: Atalar
authors.forename: I
authors.initials: I
authors.lastname: Haznedaroğlu
authors.forename: K
authors.initials: K
authors.lastname: Aytemir
authors.forename: S
authors.initials: S
authors.lastname: Aksöyek
authors.forename: K
authors.initials: K
authors.lastname: Ovünç
authors.forename: A
authors.initials: A
authors.lastname: Oto
authors.forename: F
authors.initials: F
authors.lastname: Ozmen
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000097:blood / Q000502:physiology; D003327:Coronary Disease / Q000097:blood / Q000628:therapy; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects*; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D010767:Phosphorylcholine / Q000494:pharmacology*; D012307:Risk Factors; D015607:Stents
chemical_list: D015815:Cell Adhesion Molecules; D019007:P-Selectin; D010767:Phosphorylcholine; D018799:Intercellular Adhesion Molecule-1; D006493:Heparin