title: MRI of subacute hemorrhagic transformation in the rat suture occlusion model.
abstract: In this study we investigated the utility of different MRI techniques for the detection and predictability of hemorrhagic transformation (HT) in a rat model of transient focal cerebral ischemia. Hemorrhagic infarction was reliably identified with gradient-echo sequences and developed between 2 and 7 days following the insult. None of the investigated early MRI features of the ischemic lesions (including the apparent diffusion coefficient and post-reperfusion blood-brain barrier damage) was a good predictor of HT severity at 7 days. This indicates that subacute HT at 2-7 days occurs independently of the severity of acute tissue and BBB damage.
authors.affiliation: Lucas MRI Center, Department of Radiology, Stanford Stroke Center, Stanford University, USA.
authors.forename: T
authors.initials: T
authors.lastname: Neumann-Haefelin
authors.forename: A
authors.initials: A
authors.lastname: Kastrup
authors.forename: A
authors.initials: A
authors.lastname: de Crespigny
authors.forename: T M
authors.initials: TM
authors.lastname: Ringer
authors.forename: G H
authors.initials: GH
authors.lastname: Sun
authors.forename: M A
authors.initials: MA
authors.lastname: Yenari
authors.forename: M E
authors.initials: ME
authors.lastname: Moseley
mesh_terms: D000208:Acute Disease; D000818:Animals; D001157:Arterial Occlusive Diseases / Q000175:diagnosis*; D002543:Cerebral Hemorrhage / Q000175:diagnosis*; D002544:Cerebral Infarction / Q000175:diagnosis; D004195:Disease Models, Animal; D008279:Magnetic Resonance Imaging / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020521:Stroke / Q000175:diagnosis; D013537:Sutures