[Homocysteine--CRP--lipoprotein (a). When do you evaluate the "new" risk factors].
Homocysteine, inflammatory markers (e.g. CRP), hemostatic factors (fibrinogen, PAI-1, factor VII and factor VIII) and lipoprotein (a) are independent risk factors for atherosclerotic disease. Although the association between these factors and atherosclerosis is clear, it is uncertain whether this signals a causal relationship, or whether the parameters simply represent markers of atherosclerosis. Currently, there are no reports on interventional studies demonstrating a benefit from correcting these risk factors. The determination of homocysteine, fibrinogen and lipoprotein should therefore be restricted to certain situations, such as atherosclerosis or a family history of the disease without classical risk factors, or uncertainty about the need for primary pharmacological prevention. An increase in these parameters should prompt the early use of lipid-lowering drugs or aspirin. In exceptional cases only (homocysteine), correction of the risk factors should be considered.
Parhofer
K G
KG
Medizinischen Klinik II, Klinikum Grosshadern der LMU München. parhofer@med2.med.uni-muenchen.de
D001161:Arteriosclerosis / Q000097:blood / Q000175:diagnosis*; D002097:C-Reactive Protein / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000097:blood / Q000175:diagnosis*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D012307:Risk Factors
D017270:Lipoprotein(a); D006710:Homocysteine; D002097:C-Reactive Protein
Homocystein--CRP--Lipoprotein (a). Wann bestimmen Sie die "neuen" Risikofaktoren?