Comparison of dioxin-like-response in vitro and chemical analysis of emissions and materials.
Samples from industrial and domestic emissions and materials were investigated by using in vitro assays for dioxin-like-response (DLR) and chemical analysis. The results show a small part of persistent bioaccumulative toxicants (PBT) to be responsive in vitro. Clean-up procedures directed to persistence decrease the amount of inducing toxicants substantially. The comparison of biological in vitro (B) and chemical (A) analysis show ratios between B and A below 10 for DLR of persistent inductors. The consideration of PAH improved the knowledge about unknown less persistent agonists.
Schramm
K W
KW
GSF-National Research Center for Environment and Health, Institute of Ecological Chemistry, Neuherberg, Germany. schramm@gsf.de
Klimm
C
C
Hofmaier
A
A
Kettrup
A
A
D000393:Air Pollutants / Q000032:analysis / Q000633:toxicity*; D000818:Animals; D019363:Cytochrome P-450 CYP1A1 / Q000096:biosynthesis / Q000378:metabolism; D004147:Dioxins / Q000032:analysis / Q000633:toxicity*; D004790:Enzyme Induction; D066298:In Vitro Techniques; D011083:Polycyclic Compounds / Q000032:analysis / Q000633:toxicity*; D051381:Rats; D018675:Toxicity Tests; D014407:Tumor Cells, Cultured
D000393:Air Pollutants; D004147:Dioxins; D011083:Polycyclic Compounds; D019363:Cytochrome P-450 CYP1A1