title: Synthesis of modified nucleotide building blocks containing electrophilic groups in the 2'-position.
abstract: Chemical syntheses of 2'-O-(allyloxycarbonyl)methyladenosine, 2'-O-(methoxycarbonyl)methyladenosine and 2'-O-(2,3-dibenzoyloxy)propyluridine 3'-2-cyanoethyl-N,N-diisopropyl phosphoramidite building blocks are described. These monomers were used successfully to incorporate carboxylic acid, 1,2-diol and aldehyde functionalities into synthetic oligonucleotides.
authors.affiliation: Chemistry Department and Belozersky Institute of Physical Chemical Biology, Moscow State University, Russia.
authors.forename: A V
authors.initials: AV
authors.lastname: Kachalova
authors.forename: T S
authors.initials: TS
authors.lastname: Zatsepin
authors.forename: E A
authors.initials: EA
authors.lastname: Romanova
authors.forename: D A
authors.initials: DA
authors.lastname: Stetsenko
authors.forename: M J
authors.initials: MJ
authors.lastname: Gait
authors.forename: T S
authors.initials: TS
authors.lastname: Oretskaya
mesh_terms: D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D009711:Nucleotides