Synthesis of modified nucleotide building blocks containing electrophilic groups in the 2'-position.
Chemical syntheses of 2'-O-(allyloxycarbonyl)methyladenosine, 2'-O-(methoxycarbonyl)methyladenosine and 2'-O-(2,3-dibenzoyloxy)propyluridine 3'-2-cyanoethyl-N,N-diisopropyl phosphoramidite building blocks are described. These monomers were used successfully to incorporate carboxylic acid, 1,2-diol and aldehyde functionalities into synthetic oligonucleotides.
Kachalova
A V
AV
Chemistry Department and Belozersky Institute of Physical Chemical Biology, Moscow State University, Russia.
Zatsepin
T S
TS
Romanova
E A
EA
Stetsenko
D A
DA
Gait
M J
MJ
Oretskaya
T S
TS
D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry
D009711:Nucleotides