title: [Characteristics of cardiac and nervous system impairment in patients with systemic lupus erythematosus from regions with various levels of environmental pollution].
abstract: OBJECTIVE
  To characterize clinical features of systemic lupus erythematosus (SLE) in persons living under various environmental pollution.
  
  
  METHODS
  Three groups of SLE patients living in the Orenburg region were examined: those exposed to intensive production pollution (n = 35 patients), exposed to mild pollution (n = 15), unexposed to production pollution (n = 25 patients). The pollution intensity was assessed by total aerogenic, water and soil pollution rates.
  
  
  RESULTS
  The hair from 69 patients contained 24 chemical elements. More severe clinical symptoms of SLE were registered in patients living in conditions of intensive production pollution. These symptoms' severity directly correlated with the level of heavy metals in the hair of SLE patients and inversely correlated with hair levels of essential chemical elements.
  
  
  CONCLUSIONS
  Chemical pollutants directly impair organs and tissues of SLE patients and indirectly do this via damaged immune system.
authors.forename: L K
authors.initials: LK
authors.lastname: Kozlova
authors.forename: V V
authors.initials: VV
authors.lastname: Bagirova
authors.forename: N P
authors.initials: NP
authors.lastname: Setko
mesh_terms: D000328:Adult; D009202:Cardiomyopathies / Q000453:epidemiology* / Q000473:pathology; D004781:Environmental Exposure / Q000009:adverse effects*; D004785:Environmental Pollutants / Q000009:adverse effects / Q000032:analysis; D005260:Female; D006197:Hair / Q000737:chemistry; D006349:Heart Valve Diseases / Q000453:epidemiology* / Q000473:pathology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D008297:Male; D019216:Metals, Heavy / Q000009:adverse effects / Q000032:analysis; D008875:Middle Aged; D009422:Nervous System Diseases / Q000453:epidemiology* / Q000473:pathology; D012426:Russia / Q000453:epidemiology; D012720:Severity of Illness Index
chemical_list: D004785:Environmental Pollutants; D019216:Metals, Heavy
vernacular_title: Osobennosti porazheniia serdtsa i nervnoĭ sistemy u bol'nykh sistemnoĭ krasnoĭ volchankoĭ, prozhivaiushchikh v raĭonakh s zagriazneniem vneshneĭ sredy razlichnoĭ stepeni.