title: [Remote results of proxopheline therapy of patients with primary open-angle glaucoma].
abstract: Effects of an original Russian combined preparation proxofelin, consisting of 1% proxodolol and 0.25% clofelin solutions, on intraocular pressure (IOP), hydrodynamics, ocular function, arterial pressure, and heart rate have been evaluated in 42 patients (59 eyes) with primary open-angle glaucoma for up to 2 years. Examinations were carried out before proxofelin therapy and after 6, 12, 18, and 24 months of regular therapy (twice a day). Pronounced hypotensive effect on IOP (10.0 +/- 0.3-11.2 +/- 0.2 mm Hg) was due to a significant increase (p < 0.01) in the discharge easiness coefficient (by 50-77% in comparison with the initial value) and suppressed production of aqueous humor (by 40-50% of the initial level). Visual acuity did not change, visual field was significantly (p < 0.05) extended during all terms of examinations, changes in arterial pressure and heart rate during long-term therapy were negligible. The hypotensive effect of proxofelin was insufficient in 20% patients; in such cases its combination with pilocarpin was effective. In the rest patients tolerant IOP was attained by instillations of the monopreparation. Hence, proxofelin is an effective drug for treating primary open-angle glaucoma; its efficiency is apparently due to its hypotensive action.
authors.forename: V N
authors.initials: VN
authors.lastname: Ermakova
authors.forename: S L
authors.initials: SL
authors.lastname: Malinina
authors.forename: M Zh
authors.initials: MZh
authors.lastname: Abdulkadyrova
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003000:Clonidine / Q000008:administration & dosage*; D004338:Drug Combinations; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010069:Oxadiazoles / Q000008:administration & dosage*; D016896:Treatment Outcome; D014794:Visual Fields / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D009883:Ophthalmic Solutions; D010069:Oxadiazoles; C114537:proxopheline; D003000:Clonidine
vernacular_title: Otdalennye rezul'taty lecheniia proksofelinom bol'nykh pervichnoĭ otkrytougol'noĭ glaukomoĭ.