Phytochemical study and anti-inflammatory properties of Lampaya hieronymi Schum. ex Moldenke.
The chemical study of aerial parts of Lampaya hieronymi Schum. ex Moldenke yielded oleanolic acid, epi-oleanolic acid, epi-maslinic acid, 4'7-dimethoxyapigenin, p-hydroxyacetophenone, and p-hydroxyacetophenone-beta-glucoside. In searching for natural products as potential anti-inflammatory agents, all the compounds, except 4'7-dimethoxyapigenin were evaluated in vivo for their ability to inhibit acute inflammation. Our studies demonstrated that p-hydroxyacetophenone and the triterpenes produced protective effects in carrageenan induced paw edema in mouse, at 1-3 h and 3-5 h, respectively, after the injection of carrageenan. These results indicated that their effects might correlate with the release of histamine, serotonin, kinin and prostaglandins.
Alvarez
M E
ME
Area de Química Orgánica, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, Argentina.
Rotelli
A E
AE
Pelzer
L E
LE
Saad
J R
JR
Giordano
O
O
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000302:isolation & purification* / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan