Do matrix metalloproteinases MMP-2 and MMP-9 (gelatinases) play a role in renal development, physiology and glomerular diseases?
Metalloproteinases MMP-2 and MMP-9 (also called gelatinases) are involved in cell invasion and in embryonic development and organogenesis. A growing number of reports suggest that MMP-2 and MMP-9 play some role in renal development, renal tubule physiology and glomerular pathophysiology. This editorial will focus on recent controversial data, especially those obtained from studies on MMP-9-deficient mice, which shed new light on the functions of gelatinases in normal and diseased kidneys.
Lelongt
B
B
Legallicier
B
B
Piedagnel
R
R
Ronco
P M
PM
D000818:Animals; D005314:Embryonic and Fetal Development; D007668:Kidney / Q000196:embryology / Q000502:physiology*; D007674:Kidney Diseases / Q000503:physiopathology*; D007678:Kidney Glomerulus; D007684:Kidney Tubules / Q000502:physiology; D020778:Matrix Metalloproteinase 2 / Q000502:physiology*; D020780:Matrix Metalloproteinase 9 / Q000502:physiology*
D020778:Matrix Metalloproteinase 2; D020780:Matrix Metalloproteinase 9