Modulation of neuronal activity in the nucleus raphé magnus by the 5-HT(1)-receptor agonist naratriptan in rat.
Modulatory effects of the new antimigraine drug naratriptan, a 5-HT(1)-receptor-agonist, on neurons of the nucleus raphé magnus were examined in rat by extracellular recordings. In the nucleus raphé magnus neuronal activity decreased in on-cells and increased in off-cells after intravenous administration of naratriptan. The modulatory effects of naratriptan were similar to the well-known effects of morphine on neurons in the nucleus raphé magnus. The results of this study suggest central actions of naratriptan and may point to an involvement of the endogenous pain control system in the antinociceptive effects of the 5-HT(1)-receptor-agonist.
Ellrich
Jens
J
Institute of Physiology and Experimental Pathophysiology, Friedrich-Alexander-University, Universitätsstrasse 17, D-91054 Erlangen, Germany Department of Experimental and Clinical Pharmacology and Toxicology, Emil-Fischer-Center, Friedrich-Alexander-University, Fahrstrasse 17, D-91054 Erlangen, Germany Department of Oral Physiology, Faculty of Dentistry, University of Toronto, Toronto, Ontario M5G 1G6, Canada.
Messlinger
Karl
K
Chiang
Chen Yu
CY
Hu
James W
JW
D000818:Animals; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy*; D009474:Neurons / Q000502:physiology*; D010880:Piperidines / Q000494:pharmacology*; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D014363:Tryptamines
D007211:Indoles; D010880:Piperidines; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C106783:naratriptan