title: [Early cardiovascular effects of corticotherapy for bronchopulmonary dysplasia].
abstract: OBJECTIVE
  The aim of this study was to analyze the time course of cardiovascular effects in glucocorticoid-treated premature infants with bronchopulmonary dysplasia (BPD).
  
  
  METHODS
  In a retrospective case study, 63 ventilator-dependent very-low-birth-weight neonates (mean gestational age = 27.9 +/- 2 weeks and mean birth weight = 920 +/- 275 g) treated with dexamethasone (52%) or betamethasone (48%) were studied. The average value for each study day was calculated for systolic arterial blood pressure and heart rate.
  
  
  RESULTS
  At initiation of treatment, blood pressures increased significantly from pre-treatment to day 1 and continued to increase during the first week: as a percentage of pre-treatment baseline the mean increase for systolic arterial blood pressure was 19% (95% confidence interval [CI] = 16, 22) on day 2 (P < 0.001). The maximum amplitude of variation was observed before day 2 for 75% of the study group. As a group as a whole, the heart rate value significantly decreased on day 1 (mean difference = -14.6 beats/min; 95% CI = -16.5, -12.6; P < 0.001), and then reached pre-treatment value within one week. Cardiovascular response was independent of gestational age, birth weight and postnatal age at the beginning of treatment.
  
  
  CONCLUSIONS
  During postnatal steroid therapy a rise in blood pressure is a common side effect, but bradycardia is mentioned very occasionally. The present study shows a marked increase in blood pressure during the first 48 hours concomitant with a decrease in heart rate. The inverse relationship between systolic arterial blood pressure and heart rate suggests a baroreflex response.
authors.affiliation: Centre hospitalier intercommunal poissy-Saint-Germain, Site de poissy, 10, rue du Champ-Gaillard, 78300 Poissy, France.
authors.forename: R
authors.initials: R
authors.lastname: Lenclen
authors.forename: T
authors.initials: T
authors.lastname: Karam
authors.forename: V
authors.initials: V
authors.lastname: Gajdos
authors.forename: J
authors.initials: J
authors.lastname: Mourdie
authors.forename: E
authors.initials: E
authors.lastname: Hoenn
authors.forename: K
authors.initials: K
authors.lastname: Campot
authors.forename: A
authors.initials: A
authors.lastname: Paupe
mesh_terms: D001623:Betamethasone / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D001997:Bronchopulmonary Dysplasia / Q000188:drug therapy*; D003907:Dexamethasone / Q000627:therapeutic use*; D005938:Glucocorticoids / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy*; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D003907:Dexamethasone; D001623:Betamethasone
vernacular_title: Effets cardiovasculaires précoces de la corticothérapie pour dysplasie bronchopulmonaire.