Complexation of the antihypertensive drug oxprenolol with copper(II).
The complexation between copper(II) and the antihypertensive drug oxprenolol (HOxp) was studied both in methanol and slightly alkaline aqueous media at Cu:HOxp molar ratio from 1:1 to 1:10. Copper(lI) forms two types of complexes-a mononuclear violet one, CuOxp2, with bidentately bound ligands and a green dimeric one, Cu2Oxp2Cl2, in which the two Cu(II) centres are linked by the ligand through oxygen bridges. The crystal structure of the Cu2Oxp2Cl2 complex consists of two crystallographically non-equivalent centrosymmetric copper dimers. Each copper atom is four-coordinated in a distorted square-planar environment. The Cu2O2 structural core is characterized by a Cu1-O1-Cu1' angle of 104.15(13)degrees (Cu2-O2-Cu2' 104.30(13) degrees) and a relatively short Cu1-Cu1' separation of 3.026(1) A (Cu2-Cu2'-3.023(1) A). Magnetic susceptibility and EPR measurements indicate an antiferromagnetic coupling of the copper(II) centers.
Bontchev
P R
PR
Faculty of Chemistry, Sofia University, Bulgaria. prbontchev@chem.uni-sofia.bg
Pantcheva
I N
IN
Todorov
T
T
Mehandjiev
D R
DR
Savov
N S
NS
D000959:Antihypertensive Agents / Q000737:chemistry*; D003300:Copper / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D008968:Molecular Conformation; D015394:Molecular Structure; D010096:Oxprenolol / Q000737:chemistry*
D000959:Antihypertensive Agents; D010096:Oxprenolol; D003300:Copper