[The role of histamine in vagal and gastrin effects on the secretory function of the rat stomach].
In lumen-perfused stomachs of anaesthetized rat, acid and bicarbonate types of secretion were estimated on the basis of pH/PCO2 measurements. The data obtained reveal that, in anaesthetised rats, pentagastrin and cholinergic input affect acid secretion mainly indirectly via histamine release. Vagal effects on pepsinogen output are mediated partially via indirect histamine pathways. The direct action of pentagastrin, however, predominates. Bicarbonate production is subjected to cholinergic control alone.
Khropycheva
R P
RP
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Zolotarev
V A
VA
Polenov
S A
SA
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001639:Bicarbonates / Q000378:metabolism; D002927:Cimetidine / Q000494:pharmacology; D004558:Electric Stimulation; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D005755:Gastrins / Q000502:physiology*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006632:Histamine / Q000502:physiology*; D006635:Histamine H2 Antagonists / Q000494:pharmacology; D006636:Histamine Release / Q000502:physiology; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D010418:Pentagastrin / Q000494:pharmacology; D020116:Pepsinogen A / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014630:Vagus Nerve / Q000502:physiology*
D001639:Bicarbonates; D005755:Gastrins; D006584:Hexamethonium Compounds; D006635:Histamine H2 Antagonists; D018727:Muscarinic Antagonists; D001285:Atropine; D002927:Cimetidine; D006632:Histamine; D020116:Pepsinogen A; D010418:Pentagastrin; D000109:Acetylcholine
Rol' gistaminovogo zvena v mekhanizmakh vagusnykh i gastrinovykh vliianiĭ na sekretornuiu funktsiiu zheludka krys.