Estimation of antithyroid antibodies occurrence in children with coeliac disease.
BACKGROUND
The coexistence of coeliac disease (CD) and the diseases of autoimmune origin is often discussed in literature. In this study the evaluation of antithyroid antibodies (antimicrosomal-TMA, anti-thyreoglobulin-ATG, thyroid peroxidase antibodies anti-TPO) occurrence against clinical and laboratory determinants of thyroid function is demonstrated in children with coeliac disease.


METHODS
The study was conducted on 34 IgA-EmA positive children; control group consisted of 28 children with negative screening tests for coeliac disease.


RESULTS
In both groups, the level of antithyroid antibodies (TMA, ATG, anti-TPO) and determinants of thyroid gland function (TSH, fT3, fT4) were evaluated; USG examination of thyroid gland was also performed. Elevated titres of antithyroid antibodies observed in children with coeliac disease (41.1%) in comparison to control group (3.56%) indicate the need for performing the screening tests for antithyroid antibodies in children with CD.
Kowalska
E
E
Department of Gastroenterology and Paediatric Allergology, Institute of Paediatrics, Medical University, ul. Spoma 36/50, 91-738 Łódź, Poland.
Wasowska-Królikowska
K
K
Toporowska-Kowalska
E
E
D000293:Adolescent; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D002446:Celiac Disease / Q000209:etiology / Q000276:immunology* / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007453:Iodide Peroxidase / Q000276:immunology; D008861:Microsomes / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D013961:Thyroid Gland / Q000276:immunology* / Q000503:physiopathology
D001323:Autoantibodies; D013954:Thyroglobulin; D007453:Iodide Peroxidase