title: Endothelial cell and stromal antigens in human periapical granulation tissue.
abstract: Periapical granulation tissue consists of vasculature of varying sizes and types, infiltrating cells, and other stromal elements. We examined the differential expression of endothelial and stroma antigens in this tissue to determine their tissue distribution in order to obtain hints on their functions. Some of the antigens examined were present only in the endothelial lining of vasculature, including high endothelial venules (e.g. CD31 and CD105), whereas others were more widely expressed by both vascular and stromal elements (e.g. CD29, CD63, CD44, and CD151). Immunohistochemical analysis using monoclonal antibodies specific to certain tissue compartments revealed the tissue architecture more precisely and the expression of certain antigens in the tissue suggested special roles for these antigens. Tissue distribution of CD63, CD143, CD147, and CD151 in periapical granulation tissue is first reported in the present study.
authors.affiliation: Hacettepe University, Faculty of Dentistry, Department of Endodontics, Sihhiye, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Taşman
authors.forename: A
authors.initials: A
authors.lastname: Dağdeviren
authors.forename: B
authors.initials: B
authors.lastname: Kendir
authors.forename: N
authors.initials: N
authors.lastname: Er
authors.forename: A
authors.initials: A
authors.lastname: Ataç
mesh_terms: D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis; D004396:Coloring Agents; D003238:Connective Tissue / Q000276:immunology / Q000473:pathology; D000071063:Endoglin; D004730:Endothelium, Vascular / Q000276:immunology / Q000473:pathology*; D006097:Granulation Tissue / Q000098:blood supply / Q000276:immunology / Q000473:pathology*; D006098:Granulocytes / Q000276:immunology / Q000473:pathology; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis; D007091:Image Processing, Computer-Assisted; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D019012:Integrin beta1 / Q000032:analysis; D007962:Leukocytes / Q000276:immunology / Q000473:pathology; D010486:Periapical Tissue / Q000098:blood supply / Q000276:immunology / Q000473:pathology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D010980:Platelet Membrane Glycoproteins / Q000032:analysis; D011956:Receptors, Cell Surface; D060185:Tetraspanin 24; D060149:Tetraspanin 30; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis; D014699:Venules / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000954:Antigens, Surface; C554715:CD151 protein, human; C554586:CD63 protein, human; D015815:Cell Adhesion Molecules; D004396:Coloring Agents; C064206:ENG protein, human; D000071063:Endoglin; D018960:Hyaluronan Receptors; D019012:Integrin beta1; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D060185:Tetraspanin 24; D060149:Tetraspanin 30; D019010:Vascular Cell Adhesion Molecule-1