title: Computed direct magnification radiography of bone tumors.
abstract: The purpose of this study was to assess the diagnostic performance of computed direct magnification radiography in diagnosing bone tumors as compared with conventional radiography. Ninety-one patients with primary bone tumors and tumor-like lesions were radiographed with conventional and magnification techniques. All radiographs were analyzed by one orthopedic surgeon and two radiologists and the findings were correlated with histopathology. Two microfocal X-ray units were used for computed direct magnification radiography with a focal spot size of 20-130 microm. Using magnification versus conventional radiography, the diagnosis of benign and malignant lesions as well as the individual tumor diagnosis was obtained with higher accuracy (85% versus 71% and 69% versus 51%, respectively, P<0.01). Margins of destruction, periosteal reactions, and matrix patterns were evaluated with higher accuracy by all observers (P<0.01). We conclude that computed direct magnification radiography may improve evaluation and diagnosis of bone tumors.
authors.affiliation: Department of Orthopedics, Westfälische Wilhelms-Universität, Münster, Germany. hillmaa@uni-muenster.de
authors.forename: A
authors.initials: A
authors.lastname: Hillmann
authors.forename: T M
authors.initials: TM
authors.lastname: Link
authors.forename: T
authors.initials: T
authors.lastname: Ozaki
authors.forename: T
authors.initials: T
authors.lastname: Vestring
authors.forename: W
authors.initials: W
authors.lastname: Winkelmann
mesh_terms: D000328:Adult; D001847:Bone Diseases / Q000000981:diagnostic imaging; D001859:Bone Neoplasms / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D006801:Humans; D015588:Observer Variation; D011237:Predictive Value of Tests; D011446:Prospective Studies; D011856:Radiographic Image Enhancement / Q000379:methods*