title: Pre-clinical toxicity evaluation of leaf-stalk extractive of Piper betle Linn. in rodents.
abstract: Studies on pre-clinical toxicity were undertaken to determine the haematological and biochemical changes after administration of alcoholic extract of leaf-stalk of P. betle in rats and mice. Acute and chronic toxicity experiments were performed on mice and rats according to WHO protocol. Different doses of plant extractive were administered for toxicity studies on short and long term basis. Haematological, biochemical profiles and enzymatic studies (transaminases and phosphatases) indicated that the drug (plant extractive) was devoid of toxicity.
authors.affiliation: Department of Chemistry and Centre of Advanced Studies on Natural Products, University College of Science and Technology, Calcutta University, 92, A.P.C. Road, Calcutta 700 009, India.
authors.forename: A
authors.initials: A
authors.lastname: Sengupta
authors.forename: P
authors.initials: P
authors.lastname: Adhikary
authors.forename: B K
authors.initials: BK
authors.lastname: Basak
authors.forename: K
authors.initials: K
authors.lastname: Chakrabarti
authors.forename: P
authors.initials: P
authors.lastname: Gangopadhyay
authors.forename: J
authors.initials: J
authors.lastname: Banerji
authors.forename: A
authors.initials: A
authors.lastname: Chatterjee
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D004798:Enzymes / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D010946:Plants, Medicinal / Q000737:chemistry; D051381:Rats
chemical_list: D004798:Enzymes; D010936:Plant Extracts