title: Cadmium chronic administration to lactating ewes: reproductive performance, cadmium tissue accumulation and placental transfer.
abstract: 20 lactating ewes were allotted to two groups: 10 subjects received orally 100 mg/day of CdCl2 for 108 consecutive days, and the remaining 10 acted as control. Reproductive performance in ewes and cadmium tissue accumulation, both in ewes and their lambs, were investigated. The results showed that in ewes: 1) the regular cadmium intestinal intake negatively influences all reproductive parameters; 2) cadmium is particularly accumulated in kidney and liver, but also in mammary gland, although at a distinctly lower level; 3) chronic administration does not increase cadmium placental transfer in lactating pregnant subjects.
authors.affiliation: Dipartimento di Biologia Animale, Università di Sassari, Via Vienna 2, 07100 Sassari. floris@ssmain.uniss.it
authors.forename: B
authors.initials: B
authors.lastname: Floris
authors.forename: G
authors.initials: G
authors.lastname: Bomboi
authors.forename: P
authors.initials: P
authors.lastname: Sechi
authors.forename: S
authors.initials: S
authors.lastname: Pirino
authors.forename: M L
authors.initials: ML
authors.lastname: Marongiu
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001724:Birth Weight / Q000187:drug effects; D002104:Cadmium / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007774:Lactation; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008321:Mammary Glands, Animal / Q000378:metabolism; D010920:Placenta / Q000187:drug effects / Q000378:metabolism*; D021041:Placental Circulation / Q000187:drug effects; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects*; D012756:Sheep / Q000378:metabolism / Q000502:physiology*; D012989:Soil Pollutants / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics / Q000633:toxicity; D018675:Toxicity Tests
chemical_list: D012989:Soil Pollutants; D002104:Cadmium