title: How peroxisomes arise.
abstract: Peroxisomes are formed by the synthesis and assembly of membrane proteins and lipids, the selective import of proteins from the cytosol, and the growth and division of resultant organelles. To date, 23 proteins, called peroxins, are known to participate in these processes. This review summarizes recent progress in peroxin characterization and examines the underlying molecular mechanisms of peroxisome biosynthesis.
authors.affiliation: Department of Pharmacology, Wayne State University School of Medicine, 540 East Canfield Avenue, Detroit, MI 48201, USA. s.r.terlecky@wayne.edu
authors.forename: S R
authors.initials: SR
authors.lastname: Terlecky
authors.forename: M
authors.initials: M
authors.lastname: Fransen
mesh_terms: D000818:Animals; D001693:Biological Transport, Active; D006801:Humans; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D020675:Peroxisomes / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D008563:Membrane Lipids; D008565:Membrane Proteins; D011956:Receptors, Cell Surface; C085380:peroxisomal targeting sequence receptor