[A case of leukopenia in treatment with risperidone in an adolescent].
The safety and efficacity of atypical antipsychotics in comparison with conventional neuroleptics allow their prescription in children and adolescents who are particularly at risk for developing neurological or cardiac side-effects. Hematological complications of new antipsychotics are less known, except for clozapine treatment in which blood monitoring strategy is well established. We report on a case of risperidone-associated leucopenia in an african adolescent treated for schizophrenia. He developed leucopenia 10 days after starting risperidone therapy (4 mg/day). The cessation of treatment was followed by a normalization of the white blood cell differential count and the rechallenge was positive (2 mg/day). No hematological abnormalities were observed with olanzapine therapy in this patient. Therefore olanzapine may represent a safe therapeutic alternative. We concluded that risperidone therapy may create a risk for leucopenia especially in patients who present a risk of leucopenia for ethnic reasons. We propose hematological monitoring during risperidone treatment.
Etain
B
B
Service de Psychopathologie de l'Enfant et de l'Adolescent, Hôpital Robert Debré, 48, boulevard Sérurier, 75019 Paris.
Roubaud
L
L
Le Heuzey
M F
MF
Mouren Simeoni
M C
MC
D000293:Adolescent; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001569:Benzodiazepines; D006801:Humans; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced* / Q000276:immunology; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012307:Risk Factors; D018967:Risperidone / Q000009:adverse effects* / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy* / Q000276:immunology
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D018967:Risperidone; D000077152:Olanzapine
Un cas de leucopénie sous traitement par rispéridone chez un adolescent.