title: The temporal organization of life: the impact of multi-frequency non-linear biologic time structure upon the host-cancer balance.
abstract: The current scientific paradigm, based upon an erroneous assumption of linear biologic reality and simple cause and effect relationships, has outlived its usefulness. In order to begin to turn the voluminous data the reductive process provides us with daily into meaningful understanding of life, it is essential to integrate these data within a complex, multi-frequency temporo-spatial framework. This rhythmic chronobiology more accurately depicts the life process, as well as its evolutionary and ongoing vital interaction with the pulsating cosmic resonance structure. Examples of the kinds of thinking and experiments necessary to exploit this new paradigm are provided.
authors.affiliation: WJB Dorn Veterans Affairs Medical Center and University of South Carolina School of Medicine, Columbia 29209, USA. William.Hrushesky@med.va.gov
authors.forename: W J
authors.initials: WJ
authors.lastname: Hrushesky
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D017209:Apoptosis; D002909:Chronobiology Phenomena; D016503:Drug Delivery Systems; D004358:Drug Therapy / Q000639:trends; D015870:Gene Expression; D006801:Humans; D019369:Life; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D015588:Observer Variation; D013995:Time
chemical_list: D000970:Antineoplastic Agents