title: Pathways to primary neurodegenerative disease.
abstract: Genetic analysis has revealed the pathogenic lesions that cause autosomal dominant Alzheimer's disease, prion disease, and some forms of Parkinson's disease. Molecular biological experiments based on these genetic findings allow a hypothesis to be configured linking these and the other diseases in which tangles or Lewy bodies are a pathological feature. In this article, this hypothesis is presented in the context of deriving curative treatments for these disorders.
authors.affiliation: Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, Florida 32224, USA. hardy@mayo.edu
authors.forename: J
authors.initials: J
authors.lastname: Hardy
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D006801:Humans; D010300:Parkinson Disease / Q000235:genetics / Q000473:pathology; D017096:Prion Diseases / Q000235:genetics / Q000473:pathology