title: Labelling of Re-ABP with 188Re for bone pain palliation.
abstract: Etidronate and medronate have been labelled with technetium-99m (99mTc-HEDP, 99mTc-MDP) for bone scanning and, with rhenium-188 (188Re-HEDP) to palliate the pain resulting from bone metastases. The objective of this study was to label alendronate, ABP, a new bisphosphonate, with SnF2-reduced-188Re. The reagents for the 5 mg ABP kit were SnF2, KReO4 and gentisic acid at acid pH. The chemical, spectroscopic and microscopic characteristics, quality control, rat bone uptake of [188Re]Re-ABP and similarities with 99mTc-ABP are presented. We conclude that this is a promising new radiopharmaceutical for bone metastases pain palliation.
authors.affiliation: Departamento de Medicina Nuclear, Instituto Nacional de Nutrición Salvador Zubirán, México DF, Mexico. cmurphy@data.net.mx
authors.forename: C
authors.initials: C
authors.lastname: Arteaga de Murphy
authors.forename: G
authors.initials: G
authors.lastname: Ferro-Flores
authors.forename: M
authors.initials: M
authors.lastname: Pedraza-López
authors.forename: L
authors.initials: L
authors.lastname: Meléndez-Alafort
authors.forename: B Y
authors.initials: BY
authors.lastname: Croft
authors.forename: F M
authors.initials: FM
authors.lastname: Ramírez
authors.forename: J
authors.initials: J
authors.lastname: Padilla
mesh_terms: D019386:Alendronate / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000493:pharmacokinetics / Q000627:therapeutic use; D000818:Animals; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D006801:Humans; D007202:Indicators and Reagents; D010166:Palliative Care; D011868:Radioisotopes / Q000493:pharmacokinetics / Q000627:therapeutic use*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014018:Tissue Distribution
chemical_list: D007202:Indicators and Reagents; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012211:Rhenium; D019386:Alendronate