title: Sarcoidosis in a patient with 5q-myelodysplasia. A possible pathogenetic link between the two diseases.
abstract: This study describes the occurrence of sarcoidosis with lung and skin involvements in a 56-yr-old woman who suffered from 5q-myelodysplastic syndrome since the age of 50. The 5q-myelodysplastic syndrome is marked by deletion of the long arm of chromosome 5, which carries the genes coding for T-helper cell 2 cytokines, such as interleukins-3, -4 and -5, and granulocyte-macrophage colony-stimulating factor. Although the aetiology of sarcoidosis remains unclear, sarcoid granulomatous inflammation is marked by predominant expression of T-helper cell 1 cytokines, with reduced expression of T-helper cell 2 cytokines. The authors suggest that 5q-abnormality may have predisposed to sarcoidosis through an imbalance in the cytokine network, caused by the deletion of genes coding for T-helper cell 2 cytokines.
authors.affiliation: Third Division of Internal Medicine, Ospedale Maggiore di Milano IRCCS, Milan, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Airaghi
authors.forename: D
authors.initials: D
authors.lastname: Montori
authors.forename: F
authors.initials: F
authors.lastname: Zorzi
authors.forename: A
authors.initials: A
authors.lastname: Miadonna
authors.forename: A
authors.initials: A
authors.lastname: Tedeschi
mesh_terms: D002872:Chromosome Deletion; D002895:Chromosomes, Human, Pair 5; D016207:Cytokines / Q000235:genetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000235:genetics*; D012507:Sarcoidosis / Q000150:complications*
chemical_list: D016207:Cytokines