title: Bioactive peptides derived from food proteins preventing lifestyle-related diseases.
abstract: Many kinds of bioactive peptides which might prevent lifestyle-related diseases are released from food proteins after enzymatic digestion. Inhibitory peptides for angiotensin I-converting enzyme (ACE) having anti-hypertensive effect have been isolated from enzymatic digests of various food proteins. LKPNM, which was isolated from the thermolysin digest of dried bonito was activated 8-fold by ACE itself and showed a prolonged effect after oral administration. Two vasorelaxing peptides, ovokinin and ovokinin(2-7), showing antihypertensive effect after oral administration were obtained from ovalbumin digests. We found that low molecular weight peptides derived from food proteins lowered serum cholesterol without increasing excretion of cholesterol and bile acids. An immunostimulating peptide isolated from an enzymatic digest of soybean protein prevented alopecia induced by cancer chemotherapy.
authors.affiliation: Research Institute for Food Science, Kyoto University, Uji, Kyoto, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: N
authors.initials: N
authors.lastname: Matoba
authors.forename: Y
authors.initials: Y
authors.lastname: Takenaka
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: R
authors.initials: R
authors.lastname: Yamauchi
authors.forename: H
authors.initials: H
authors.lastname: Tsuruki
authors.forename: K
authors.initials: K
authors.lastname: Takahata
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000627:therapeutic use; D004044:Dietary Proteins / Q000378:metabolism / Q000627:therapeutic use*; D004194:Disease / Q000209:etiology*; D004527:Egg Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D010450:Endopeptidases / Q000378:metabolism; D005502:Food; D006801:Humans; D007109:Immunity / Q000187:drug effects; D008019:Life Style; D010047:Ovalbumin / Q000378:metabolism; D010446:Peptide Fragments / Q000008:administration & dosage / Q000627:therapeutic use; D010455:Peptides / Q000378:metabolism / Q000627:therapeutic use*; D011315:Preventive Medicine; D030262:Soybean Proteins / Q000378:metabolism / Q000627:therapeutic use
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000924:Anticholesteremic Agents; D000959:Antihypertensive Agents; D004044:Dietary Proteins; D004527:Egg Proteins; D010446:Peptide Fragments; D010455:Peptides; D030262:Soybean Proteins; C096585:ovokinin; D010047:Ovalbumin; D010450:Endopeptidases