title: [Midodrine (Gutron) prescription practice at a University Hospital Center].
abstract: A historical study of the prescription of midodrine was carried out at the university hospital of Toulouse (France) between 1994 and 1998. The aim was to compare the observed prescriptions and the ideal prescriptions in accordance with the Summary of Product Characteristics (SPC). The analysis of 97 consecutive medical reports found discrepancies in prescription concerning the non-respect of contraindications and of potentially hazardous drug associations. Fifty-four (55.7 per cent) patients would have been excluded from prescription if the physicians had strictly respected the SPC. The inappropriate prescription of midodrine was associated with an increase in adverse drug reactions (ADRs). ADRs occurred in 34.0 per cent of cases overall and required drug discontinuation in 15.5 per cent.
authors.affiliation: Laboratoire de Pharmacologie Médicale et Clinique, INSERM U317, Faculté de Médecine, 37 allées Jules-Guesde, 31073 Toulouse, France.
authors.forename: K
authors.initials: K
authors.lastname: Desboeuf
authors.forename: J M
authors.initials: JM
authors.lastname: Senard
authors.forename: A
authors.initials: A
authors.lastname: Pavy-Le-Traon
authors.forename: C
authors.initials: C
authors.lastname: Brefel
authors.forename: M
authors.initials: M
authors.lastname: Clanet
authors.forename: G
authors.initials: G
authors.lastname: Géraud
authors.forename: J L
authors.initials: JL
authors.lastname: Montastruc
mesh_terms: D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000009:adverse effects; D016907:Adverse Drug Reaction Reporting Systems / Q000706:statistics & numerical data; D002318:Cardiovascular Diseases / Q000139:chemically induced; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D004363:Drug Utilization / Q000706:statistics & numerical data; D017723:Drug Utilization Review / Q000706:statistics & numerical data; D005602:France; D006785:Hospitals, University / Q000706:statistics & numerical data; D006801:Humans; D007022:Hypotension / Q000188:drug therapy; D008137:Longitudinal Studies; D008499:Medical Records; D008879:Midodrine / Q000009:adverse effects; D010292:Paresthesia / Q000139:chemically induced; D011355:Prodrugs / Q000009:adverse effects; D012189:Retrospective Studies; D016055:Urinary Retention / Q000139:chemically induced; D014662:Vasoconstrictor Agents / Q000009:adverse effects
chemical_list: D058646:Adrenergic alpha-1 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D011355:Prodrugs; D014662:Vasoconstrictor Agents; D008879:Midodrine
vernacular_title: Etude des pratiques de prescriptions de midodrine (Gutron) dans un Centre Hospitalier Universitaire.