Considerations for drug therapy in hypertension.
Both the Joint National Committee and the British Hypertension Society recommend b-blockers and diuretics as first-line therapy in the treatment of uncomplicated hypertension. As a result, many clinicians will also prescribe these drugs in the treatment of patients with hypertension and coexistent disease (unless they are specifically contraindicated), even though they may not always be the most beneficial choice. This review aims to examine factors that should be taken into consideration when choosing appropriate antihypertensive therapy. Particular attention is given to treatment options in two special patient groups, the elderly and patients with co-morbid diabetes, as these groups have an increased risk of developing cardiovascular complications. In response to the increasing evidence base from large-scale trials, the article concludes that cardiovascular risk factors, coexisting disease, concomitant medication and age should all be taken into account when choosing antihypertensive therapy.
McNally
P
P
Department of Diabetes and Endocrinology, Leicester Royal Infirmary, Leics, UK.
D000367:Age Factors; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D000075202:Contraindications; D003657:Decision Making; D048909:Diabetes Complications; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D007333:Insulin Resistance / Q000502:physiology; D008055:Lipids / Q000097:blood; D017410:Practice Guidelines as Topic; D012307:Risk Factors
D000959:Antihypertensive Agents; D008055:Lipids