[Polymethylene derivatives of nucleic bases with omega-functional groups. Pyrimidine derivatives].
N1-Acyclic derivatives of pyrimidine bases (uracil, thymine, and cytosine) with hydrophobic polymethylene chains containing various functional groups in an omega-position of the alkyl substituent were synthesized. Their physicochemical properties and inhibitory effect on the HIV reverse transcriptase and human DNA topoisomerase I were studied.
Makinskiĭ
A A
AA
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow 117984, Russia.
Kritsyn
A M
AM
Ul'ianova
E A
EA
Zakharova
O D
OD
Nevinskiĭ
G A
GA
D003596:Cytosine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D004264:DNA Topoisomerases, Type I / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors / Q000737:chemistry; D006801:Humans; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000737:chemistry; D013329:Structure-Activity Relationship; D013941:Thymine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D059004:Topoisomerase I Inhibitors; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry
D004791:Enzyme Inhibitors; D018894:Reverse Transcriptase Inhibitors; D059004:Topoisomerase I Inhibitors; D014498:Uracil; D003596:Cytosine; D054303:HIV Reverse Transcriptase; D004264:DNA Topoisomerases, Type I; D013941:Thymine
Polimetilenovye proizvodnye nukleinovykh osnovaniĭ s omega-funktsional'nymi gruppami. Pirimidinovye proizvodnye.