[Expression of vascular endothelial growth factor receptor kinase inser domain containing receptor in human cervical carcinoma].
OBJECTIVE
To observe the expression of vascular endothelial growth factor receptor (KDR) in human cervical carcinomas, to clarify the relationship between the expression and invasion, metastasis, prognostic value in human cervical carcinoma.


METHODS
KDR was stained immunohistochemically in 80 cases of human cervical carcinoma.


RESULTS
The expression of KDR in the endothelial cells of tumor vasculature is: the high KDR expression rate of clinical cancer stages < or = I b and II a-III a was 21.4% and 60.6% (P < 0.01). The high KDR expression rate of the high, middle and low pathohistologic grading was 7.7%, 27.8% and 84.1% respectively (P < 0.01). The high KDR expression rate of adenocarcinoma and squamous-cell carcinoma was 0/5 and 57.3% (P < 0.05). The high KDR expression rate of the cases with lymphonodus metastasis and without lymphonodus metastasis was 77.8% and 46.8% respectively (P < 0.05). The survival rate of patients with high KDR expression tumors was significantly lower than that of patients with low KDR expression (P < 0.05).


CONCLUSIONS
KDR is highly related to growth, invasion and metastasis of human cervical carcinoma, it may be one of the predictors for the biological behavior of human cervical carcinoma.
Di
H
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Department of Obstetrics and Gynecology, Obstetrics and Gynecology Hospital of Jilin City, Jilin 132011, China.
Xu
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F
Wang
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D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis*; D017978:Receptors, Growth Factor / Q000096:biosynthesis*; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
D017978:Receptors, Growth Factor; D020794:Receptor Protein-Tyrosine Kinases