title: Some reactions of 2-cyanomethyl-3-methyl-3H-imidazo[4,5-b]pyridine with isothiocyanates. Antituberculotic activity of the obtained compounds.
abstract: Some reactions of 2-cyanomethyl-3-methyl-3H-imidazo[4,5-b]pyridine with isothiocyanates were carried out. New derivatives of imidazo[4,5-b]pyridine with different substituents in 2-position and derivatives of the new pyrido-imidazo-thiazine ring system were synthesized. Most of the obtained compounds were tested for their in vitro antituberculotic activity.
authors.affiliation: Department of Organic Chemistry, Medical University of Gdańsk, Poland.
authors.forename: L
authors.initials: L
authors.lastname: Bukowski
mesh_terms: D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000737:chemistry*; D017879:Isothiocyanates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009570:Nitriles / Q000737:chemistry*; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
chemical_list: C421982:2-cyanomethyl-3-methyl-3H-imidazo(4,5-b)pyridine; D000995:Antitubercular Agents; D007093:Imidazoles; D017879:Isothiocyanates; D009570:Nitriles; D011725:Pyridines