Effect of thiamine on the cadmium-chelating capacity of thiol compounds.
The influence of thiamine on the efficacy of meso-2,3-dimercaptosuccinic acid (DMSA), diethyldimercapto succinate (DEDMS), alpha mercapto-beta-(2-furyl) acrylic acid (MFA) and alpha-mercapto-beta-(2-thienyl) acrylic acid (MTA) to mobilize cadmium and reverse cadmium-induced biochemical alterations was investigated in cadmium-exposed rats. The thiamine coadministration enhanced the efficacy of MFA and MTA in reducing hepatic and renal burden of cadmium and that of DMSA and DEDMS in mobilizing hepatic cadmium. It also improved the efficacy of DMSA, DEDMS and MFA in reversing the cadmium-induced increase in urinary alkaline phosphatase and aspartate and alanine amino transaminases. The combined treatment with thiamine and DMSA or MFA restricted the urinary loss of zinc and that with thiamine and DEDMS reduced the loss of fecal copper, a general effect of chelation. In conclusion, the administration of thiamine during chelation therapy in cadmium poisoning may be beneficial and more effective than thiol chelating agents alone, which needs to be confirmed in humans.
Tandon
S K
SK
Industrial Toxicology Research Centre, Lucknow, India.
Prasad
S
S
D000179:Acrylates / Q000494:pharmacology; D000818:Animals; D002104:Cadmium / Q000378:metabolism / Q000633:toxicity*; D002614:Chelating Agents / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D051381:Rats; D004113:Succimer / Q000031:analogs & derivatives* / Q000494:pharmacology; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D013831:Thiamine / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism
D000179:Acrylates; D002614:Chelating Agents; D013438:Sulfhydryl Compounds; C421867:mercapto-(2-thienyl)acrylic acid; D002104:Cadmium; C056139:diethyl dimercaptosuccinate; C015341:2-mercapto-3-furan-2-ylpropenoic acid; D004113:Succimer; D015032:Zinc; D013831:Thiamine