title: Visual hallucination and tremor induced by sertraline and oxycodone in a bone marrow transplant patient.
abstract: The authors report a case of probable serotonin syndrome caused by the coadministration of sertraline and oxycodone. A 34 year-old male patient experienced visual hallucinations and severe tremor after dramatically increasing his dosage of oxycodone while on stable amounts of sertraline and cyclosporin. Discontinuation of cyclosporin did not result in resolution of his symptoms. Consideration of a possible sertraline-oxycodone interaction led to withholding sertraline, which resulted in symptom resolution. Serotonin syndrome has been noted with sertraline in combination with other drugs, but this is the first report in combination with a narcotic analgesic. Possible pharmacological mechanisms are discussed. In complicated patients that are taking multiple medications, physicians should be aware of this possible interaction to avoid delay in the diagnosis of serotonin syndrome.
authors.affiliation: Department of Pharmacology and Medicine, Division of Clinical Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Rosebraugh
authors.forename: D A
authors.initials: DA
authors.lastname: Flockhart
authors.forename: S U
authors.initials: SU
authors.lastname: Yasuda
authors.forename: R L
authors.initials: RL
authors.lastname: Woosley
mesh_terms: D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects; D000996:Antitussive Agents / Q000009:adverse effects; D016026:Bone Marrow Transplantation / Q000523:psychology*; D006212:Hallucinations / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010098:Oxycodone / Q000009:adverse effects*; D020280:Sertraline / Q000009:adverse effects*; D014202:Tremor / Q000139:chemically induced*
chemical_list: D000928:Antidepressive Agents; D000996:Antitussive Agents; D010098:Oxycodone; D020280:Sertraline