title: Antimycotic agents in oral candidosis: an overview: 2. Treatment of oral candidosis.
abstract: As both humans and fungi are eukaryotic organisms, antifungal agents affect their cellular metabolism. Thus, a relatively few antifungals with minimal toxicity and side-effects are available compared with a plethora of antibacterials. These agents currently prescribed in dentistry belong to two major groups, the polyenes (nystatin and amphotericin B) and the azoles (imidazoles and triazoles). A newly recognized phenomenon known as the post-antifungal effect implies that antifungals, even at sub-therapeutic concentrations, may suppress the virulent attributes of yeasts, especially intra-orally where topical drug levels fluctuate dramatically during dosing intervals.
authors.affiliation: Department of Oral Medicine & Periodontology, Faculty of Dental Sciences, University of Peradeniya, Sri Lanka.
authors.forename: A N
authors.initials: AN
authors.lastname: Ellepola
authors.forename: L P
authors.initials: LP
authors.lastname: Samaranayake
mesh_terms: D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use; D000935:Antifungal Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000145:classification / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects / Q000254:growth & development / Q000472:pathogenicity; D002180:Candidiasis, Oral / Q000188:drug therapy*; D003022:Clotrimazole / Q000008:administration & dosage / Q000627:therapeutic use; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use; D007654:Ketoconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008825:Miconazole / Q000008:administration & dosage / Q000627:therapeutic use; D009761:Nystatin / Q000008:administration & dosage / Q000627:therapeutic use; D014774:Virulence / Q000187:drug effects
chemical_list: D000935:Antifungal Agents; D009761:Nystatin; D017964:Itraconazole; D008825:Miconazole; D000666:Amphotericin B; D015725:Fluconazole; D003022:Clotrimazole; D007654:Ketoconazole