Hepatic angiosarcoma occurring after cyclophosphamide therapy: case report and review of the literature.
A 54-year-old man with polyarteritis nodosa developed acute onset of right upper quadrant abdominal pain associated with a large liver mass. Transvenous liver biopsy revealed hepatic angiosarcoma, a rare liver tumor classically associated with environmental toxins. He had been treated with oral cyclophosphamide for 13 years. A review of the literature revealed two other cases of hepatic angiosarcoma in patients after long-term cyclophosphamide treatment. We propose that cyclophosphamide be added to the list of exposures potentially associated with hepatic angiosarcoma.
Rosenthal
A K
AK
Department of Medicine, Medical College of Wisconsin, Milwaukee, USA. akrose@mcw.edu
Klausmeier
M
M
Cronin
M E
ME
McLaughlin
J K
JK
D003520:Cyclophosphamide / Q000009:adverse effects*; D006394:Hemangiosarcoma / Q000139:chemically induced*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D010488:Polyarteritis Nodosa / Q000188:drug therapy
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide