title: Histological changes of the pancreas in an elderly diabetic patient positive for GAD antibody.
abstract: We examined the histological changes of the pancreas in a 75-year-old diabetic woman who was treated with sulphonylurea for 10 years and required insulin treatment for the subsequant 10 years. She was positive for antiglutamic acid decarboxylase antibody (GAD Ab) 20 years after the diagnosis of diabetes. Her autopsied pancreas revealed disfigured islets and no beta cells. These changes were indistinguishable from those of the long-sustained type 1 diabetes mellitus, and insulitis was not found. This case suggests that diabetic patients positive for the GAD Ab, even if oral hypoglycemic agents are effective, may develop complete beta cell destruction over a long period.
authors.affiliation: Department of Internal Medicine, Matsuyama Shimin Hospital, Ehime.
authors.forename: S
authors.initials: S
authors.lastname: Murao
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: J
authors.initials: J
authors.lastname: Takahara
mesh_terms: D000368:Aged; D000918:Antibody Specificity; D001284:Atrophy; D001323:Autoantibodies / Q000097:blood / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D003928:Diabetic Nephropathies / Q000209:etiology; D003930:Diabetic Retinopathy / Q000209:etiology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D005968:Glutamate Decarboxylase / Q000276:immunology*; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000627:therapeutic use; D007515:Islets of Langerhans / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000209:etiology; D009404:Nephrotic Syndrome / Q000209:etiology; D010179:Pancreas / Q000473:pathology*; D013453:Sulfonylurea Compounds / Q000627:therapeutic use; D013967:Thyroiditis, Autoimmune / Q000150:complications
chemical_list: D001323:Autoantibodies; D001324:Autoantigens; D007004:Hypoglycemic Agents; D007328:Insulin; D013453:Sulfonylurea Compounds; D005968:Glutamate Decarboxylase