[Role of xenobiotic biotransformation enzymes in susceptibility to bronchial asthma and in formation of its clinical phenotypic features].
The paper shows the impact of some mutations of CYP1A, GSTM1, GSTT1, and NAT2 genes and different combinations of alleles of these genes on susceptibility to bronchial asthma and its clinical features. Passive smoking modulates these relationships.
Liakhovich
V V
VV
Vavilin
V A
VA
Makarova
S I
SI
Gavalov
S M
SM
Riabova
O A
OA
Chasovnikova
O B
OB
Gutkina
N I
NI
D000293:Adolescent; D000483:Alleles; D001191:Arylamine N-Acetyltransferase / Q000235:genetics / Q000378:metabolism*; D001249:Asthma / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D015415:Biomarkers; D002648:Child; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics / Q000378:metabolism*; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008297:Male; D009154:Mutation; D010641:Phenotype; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D015262:Xenobiotics / Q000009:adverse effects*
D001191:Arylamine N-Acetyltransferase; D015415:Biomarkers; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; D014028:Tobacco Smoke Pollution; D015262:Xenobiotics; C478900:NAT2 protein, human; C413545:glutathione S-transferase T1
Rol' fermentov biotransfomatsii ksenobiotikov v predraspolozhennosti k bronkhial'noĭ astme i formirovanii osobennosteĭ ee klinicheskogo fenotipa.