title: Distribution and pharmacokinetics of the gonadotrophin releasing hormone analogue (Gn-RH analogue) dalarelin in rats.
abstract: The dynamics of concentration changes for dalarelin in the blood as well as in organs and tissues at different times from its administration to female rats as a single subcutaneous injection, was observed. Also, the basic pharmacokinetic parrameters were determined. The maximum concentration of dalarelin in the blood (Cmax), which was 261.5 pg/cm3, was observed at the maximum time (tmax) 30 min, after its subcutaneous administration. The simplest equation describing the observed concentration changes for dalarelin in the blood is a tri-exponential equation of an open two-compartment model. The obtained results indicate that dalarelin is selectively captured by the pituitary as well as by the non-specific organs: heart, brain and uterus. It allows us to conclude that it has a wider spectrum of activity.
authors.affiliation: Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, 41-205 Sosnowiec, ul. Kasztanowa 3, Poland.
authors.forename: B
authors.initials: B
authors.lastname: Dolinska
authors.forename: F
authors.initials: F
authors.lastname: Ryszka
authors.forename: A
authors.initials: A
authors.lastname: Suszka-Switek
mesh_terms: D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
chemical_list: C404725:dalarelin; D007987:Gonadotropin-Releasing Hormone