title: Identification of novel single nucleotide polymorphisms in intron 1B and exon 1C of the human interleukin-1 receptor type I (IL-1RI) gene.
abstract: We have identified two novel single nucleotide polymorphisms in the 5' region of the human IL-1RI gene: (1) A-->G at position 52 in intron 1B (GenBank accession number AF146426), which creates an Mspl restriction endonuclease site. Allele frequencies in a Caucasian population were 0.1 (A allele) and 0.9 (G allele). (2) A-->T at position 140 in exon 1C (GenBank accession number AF146427). Allele frequencies in a Caucasian population were 0.27 (A allele) and 0.73 (T allele).
authors.affiliation: Department of Pathology and Microbiology, Homoeopathic Hospital Site, Cotham, Bristol BS6 6JU, UK. D.Sitara@bris.ac.uk
authors.forename: D
authors.initials: D
authors.lastname: Sitara
authors.forename: O
authors.initials: O
authors.lastname: Olomolaiye
authors.forename: N
authors.initials: N
authors.lastname: Wood
authors.forename: L
authors.initials: L
authors.lastname: Keen
authors.forename: H
authors.initials: H
authors.lastname: Morse
authors.forename: C
authors.initials: C
authors.lastname: Elson
authors.forename: C
authors.initials: C
authors.lastname: Westacott
authors.forename: J
authors.initials: J
authors.lastname: Bidwell
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000032:analysis; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007438:Introns / Q000235:genetics; D008297:Male; D008969:Molecular Sequence Data; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics; D017472:Receptors, Interleukin-1 / Q000235:genetics*; D053573:Receptors, Interleukin-1 Type I; D015183:Restriction Mapping
chemical_list: D017472:Receptors, Interleukin-1; D053573:Receptors, Interleukin-1 Type I; D004247:DNA