[Hemostimulant effect of pantohematogen in myelosuppression induced by cytostatics].
Pantohematogen stimulates hemopoiesis in mice with cyclophosphane induced bone marrow hypoplasia. The hemopoiesis recovery activated by pantohematogen is manifested by the granulocyte lineage hyperplasia in the bone marrow, rapid restoration of the polymorphonuclear leukocyte and monocyte counts in the peripheral blood, and the development of neutrophilia and monocytosis. The activation effect of pantohematogen on the bone marrow hemopoiesis is related to stimulating the precursor cell proliferation and differentiation and to increasing the functional activity of the hemopoietic microenvironment.
Dygaĭ
A M
AM
Institute of Pharmacology, Tomsk Scientific Center, Siberian Division, Russian Academy of Medical Sciences, pr. Lenina 3, Tomsk, 634028 Russia.
Gur'iantseva
L A
LA
Zhdanov
V V
VV
Pozhen'ko
N S
NS
Simanina
E V
EV
Suslov
N I
NI
Gol'dberg
V E
VE
D000485:Allergens / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001685:Biological Factors; D001772:Blood Cell Count; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects*; D003114:Colony-Forming Units Assay; D003520:Cyclophosphamide / Q000633:toxicity*; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009000:Monocytes / Q000166:cytology / Q000187:drug effects; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects
D000485:Allergens; D000970:Antineoplastic Agents; D001685:Biological Factors; C404022:pantohematogen; D003520:Cyclophosphamide
Gemostimuliruiushchie svoĭstva pantogematogena v usloviiakh mielosupressii, vyzvannoĭ tsitostatikami.