title: [Dynamic liver function study using the lidocaine test].
abstract: Lidocaine clearance test may reflect the integrity of various oxidative pathways of hepatocytes. Lidocaine is a highly sensitive indicator of hepatic dysfunction. This test is applicable to assessment of stage and prognosis of the liver disease, to timing of the liver transplantation, and to assessment of the pretransplant prognosis in the end-stage of chronic liver disease. Formation of the major lidocaine metabolite monoethylglycinexylidide (MRGX) depends on the hepatic cytochrome P-450 activity and on the liver blood flow.
authors.affiliation: Ustav klinické biochemie a patobiochemie, Praha.
authors.forename: K
authors.initials: K
authors.lastname: Sídlová
authors.forename: R
authors.initials: R
authors.lastname: Průsa
mesh_terms: D006801:Humans; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008111:Liver Function Tests
chemical_list: D008012:Lidocaine; C001173:monoethylglycinexylidide
vernacular_title: Dynamické vysetrení funkce jater pomocí lidokainového testu.