title: Chronic systemic (hepatosplenic) candidiasis in a patient with granulocytic sarcoma.
abstract: Chronic systemic (hepatosplenic) candidiasis (CSC) is a syndrome of invasive candidiasis characterized by fever without localizing signs or symptoms. It occurs predominantly in patients with acute leukemia, after prolonged severe neutropenia. We report a young woman who underwent extensive chemotherapy for granulocytic sarcoma of the ovary; CSC then developed in this patient. She was successfully treated with fluconazole and liposomal amphotericin B. Clinical presentation, diagnostic problems, and the current successful treatment with fluconazole and liposomal amphotericin B are discussed.
authors.affiliation: Division of Medical Oncology, Regional Cancer Centre, Thiruvananthapuram, India.
authors.forename: V P
authors.initials: VP
authors.lastname: Gangadharan
authors.forename: K
authors.initials: K
authors.lastname: Sasidharan
authors.forename: S
authors.initials: S
authors.lastname: Preetha
authors.forename: K
authors.initials: K
authors.lastname: Chithrathara
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002908:Chronic Disease; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D009894:Opportunistic Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000150:complications* / Q000188:drug therapy; D012509:Sarcoma / Q000150:complications* / Q000188:drug therapy; D013158:Splenic Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D015725:Fluconazole