Does maternal or paternal heredity affect carotid atherosclerosis in children with familial hypercholesterolaemia?
Maternal hypercholesterolaemia has recently been shown to increase the number of fatty streaks in the foetal aorta, as well as subsequent progression of fatty streaks to more advanced lesions. We compared carotid intima-media thickness by B-mode ultrasonography in children who inherited familial hypercholesterolaemia from their mothers or fathers, hypothesizing that children whose mothers were hypercholesterolaemic during pregnancy had increased atherogenesis compared with children whose mothers did not have familial hypercholesterolaemia. We found that carotid intima-media thickness and prevalence of plaque did not differ between children with familial hypercholesterolaemia who inherited FH maternally or paternally.
Tonstad
S
S
Lipid Clinic, Medical Department A, Rikshospitalet, Oslo, Norway. serena.tonstad@ulleval.no
Joakimsen
O
O
Leren
T P
TP
Ose
L
L
D000293:Adolescent; D000328:Adult; D002340:Carotid Artery Diseases / Q000209:etiology* / Q000235:genetics; D002648:Child; D005220:Fathers; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications*; D008297:Male; D009035:Mothers; D012044:Regression Analysis; D012307:Risk Factors; D017678:Sex Distribution; D017539:Tunica Intima / Q000000981:diagnostic imaging; D014463:Ultrasonography