title: Skeletal muscle relaxants: pharmacodynamics and pharmacokinetics in different patient groups.
abstract: Muscle relaxants can be safely administered during anaesthesia, providing the basic pharmacodynamic and pharmacokinetic characteristics of the compounds together with the physiological status of the patient are known. In this review the pharmacodynamics and pharmacokinetics of the neuromuscular blocking agents are discussed and related to the physical health or disease state of groups of patients.
authors.affiliation: Institute for Anaesthesiology, University Hospital Sint Radboud, University of Nijmegen, Nijmegen.
authors.forename: L H
authors.initials: LH
authors.lastname: Booij
authors.forename: T B
authors.initials: TB
authors.lastname: Vree
mesh_terms: D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D000367:Age Factors; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000188:drug therapy; D009467:Neuromuscular Depolarizing Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009468:Neuromuscular Diseases / Q000188:drug therapy; D003473:Neuromuscular Nondepolarizing Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D000759:Adjuvants, Anesthesia; D009467:Neuromuscular Depolarizing Agents; D003473:Neuromuscular Nondepolarizing Agents