title: Multicentric study of the effect of milk fermented by Lactobacillus casei on the incidence of diarrhoea.
abstract: The aim of this study was to determine if supplementation of healthy children with milk fermented by yogurt cultures and Lactobacillus casei strain DN-114 001 could affect the incidence of acute diarrhoea when compared with traditional yogurt. The study was a multicentre, randomised, double-blind trial, conducted over four months, on 928 children aged, at inclusion, 6-24 months. The study consisted of two periods: supplementation and observation. Subjects were supplemented daily with 100 g of one of the two dairy products being tested: standard yogurt and milk fermented by yogurt cultures and Lactobacillus casei (10(8) cfu/ml). Frequency or duration of any diarrhoea episode was evaluated. As far as frequency was concerned there was a statistically significant difference between the groups, the incidence of diarrhoea being significantly reduced by supplementation with L. casei fermented milk (15.9%) compared with yogurt (22%) (p = 0.03). These results suggest an additional benefit of L. casei in acute diarrhoea in children compared with standard yogurt.
authors.affiliation: CIRDC (Centre International de Recherche Daniel Carasso), Groupe Santé-Nutrition, 15 avenue Galilée, 92350 Le Plessis Robinson, France.
authors.forename: C A
authors.initials: CA
authors.lastname: Pedone
authors.forename: C C
authors.initials: CC
authors.lastname: Arnaud
authors.forename: E R
authors.initials: ER
authors.lastname: Postaire
authors.forename: C F
authors.initials: CF
authors.lastname: Bouley
authors.forename: P
authors.initials: P
authors.lastname: Reinert
mesh_terms: D000208:Acute Disease; D000818:Animals; D002675:Child, Preschool; D003967:Diarrhea / Q000517:prevention & control* / Q000821:virology; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007780:Lacticaseibacillus casei; D008297:Male; D008892:Milk / Q000382:microbiology*; D012400:Rotavirus Infections / Q000150:complications; D015014:Yogurt / Q000382:microbiology*