The NKG2 natural killer cell receptor family: comparative analysis of promoter sequences.
The NKG2 receptor family is crucially involved in target cell recognition by natural killer cells and comprises several activating as well as inhibitory family members. We have established approximately 3 kilobases of upstream promoter sequences of the human NKG2-C, -E and -F genes and have carried out a comparative analysis with available NKG2-A sequences. We found extended regions of homology which contain numerous putative transcription factor binding sites conserved in the NKG2 genes. However, variation in Alu insertion among family members has led to promoter structures unique to the respective family members, which could contribute to differences in transcriptional initiation as well as gene-specific regulation.
Brostjan
C
C
Department of Surgery, Vienna General Hospital 8G9.05, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria.
Sobanov
Y
Y
Glienke
J
J
Hayer
S
S
Lehrach
H
H
Francis
F
F
Hofer
E
E
D001483:Base Sequence; D002460:Cell Line; D004247:DNA; D015870:Gene Expression; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology; D008969:Molecular Sequence Data; D055654:NK Cell Lectin-Like Receptor Subfamily C; D011401:Promoter Regions, Genetic; D011971:Receptors, Immunologic / Q000235:genetics*; D055607:Receptors, Natural Killer Cell
C527054:KLRC1 protein, human; C527059:KLRC2 protein, human; D055654:NK Cell Lectin-Like Receptor Subfamily C; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell; D004247:DNA