[Effect of cytomedins on development of organotypic culture of various tissues from the internal organs of rats].
Some natural peptides, referred to as cytomedines, were isolated from different organs: cortexin and epithalamin (both from the brain), cordialin (heart), hepalin (liver) and thymalin (thymus),--to test their stimulating effects on the growth in organotypic culture of different tissue explants taken from 3 day old rats. It has been found that these peptides exerted their obvious stimulating effects on the growth of the cultured explants, compared to the control, if taken in the respective concentrations: 100, 50, 50, 100 and 5 ng/ml. Thus, these cytomedins can be used in the clinical practice for stimulating reparative processes in the appropriate tissues.
Chalisova
N I
NI
Pavlov Institute of Physiology RAS, Institute of Bioregulation and Gerontology RAMS, St. Petersburg.
Khavinson
V Kh
VKh
Davydenko
V V
VV
Dorovskiĭ
A A
AA
Verbovaia
T A
TA
Penniiaĭnen
V A
VA
D000818:Animals; D001921:Brain / Q000254:growth & development; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects / Q000254:growth & development; D008099:Liver / Q000187:drug effects / Q000254:growth & development; D009924:Organ Culture Techniques; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013950:Thymus Gland / Q000187:drug effects / Q000254:growth & development
D010455:Peptides; C053892:cytomedins
Vliianie tsitomedinov na razvitie organotipicheskoĭ kul'tury razlichnykh tkaneĭ vnutrennikh organov krysy.