Effect of fluconazole on agar invasion by Candida albicans.
Subinhibitory concentrations of azoles are known to inhibit hyphal branching of Candida albicans in liquid media. This study showed that subinhibitory concentrations of fluconazole also inhibit agar invasion by C. albicans in YPD solid medium. Agar invasion was markedly inhibited in two C. albicans strains that were resistant to fluconazole. This suggests that the degree to which fluconazole inhibits agar invasion by C. albicans hyphae could serve as a marker of susceptibility to azoles.
Kontoyiannis
Dimitrios P
DP
*Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
Tarrand
Jeffrey
J
*Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
Prince
Randall
R
*Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
Samonis
George
G
*Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
Rolston
Kenneth V R
KVR
*Section of Infectious Diseases, Department of Internal Medicine Specialties and †Department of Laboratory Medicine, University of Texas M.D. Anderson Cancer Center and ‡College of Pharmacy, University of Houston, Houston, TX, USA.
D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000254:growth & development*; D002177:Candidiasis / Q000382:microbiology; D003470:Culture Media; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000592:standards
D000935:Antifungal Agents; D003470:Culture Media; D015725:Fluconazole