title: [Synthesis of protective antigens during submerged cultivation of Vibrio cholerae].
abstract: The effectiveness of dot immunoanalysis for evaluating the dynamics of the synthesis of O-antigen, cholera toxin, neuraminidase, adhesin CFA1 in the process of the reactor cultivation of V. cholerae used for the production of oral chemical cholera vaccine is shown. The established regularities of the synthesis of the protective antigens of V. cholerae in the process of scaled-up cultivation are discussed.
authors.affiliation: Research Institute for Plague Control Microbe, Saratov, Russia.
authors.forename: V A
authors.initials: VA
authors.lastname: Fedorova
authors.forename: N A
authors.initials: NA
authors.lastname: Syrova
authors.forename: O V
authors.initials: OV
authors.lastname: Gromova
authors.forename: N E
authors.initials: NE
authors.lastname: Tershkina
authors.forename: Z L
authors.initials: ZL
authors.lastname: Devdariani
authors.forename: M N
authors.initials: MN
authors.lastname: Dzhaparidze
authors.forename: M V
authors.initials: MV
authors.lastname: Meleshchenko
authors.forename: G V
authors.initials: GV
authors.lastname: Dobrova
authors.forename: N I
authors.initials: NI
authors.lastname: Beliakova
authors.forename: N M
authors.initials: NM
authors.lastname: Ermakov
authors.forename: Iu Iu
authors.initials: IuIu
authors.lastname: Eliseev
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000096:biosynthesis*; D001426:Bacterial Proteins / Q000378:metabolism*; D002772:Cholera Toxin / Q000378:metabolism; D036781:Fimbriae Proteins; D015151:Immunoblotting; D051379:Mice; D008807:Mice, Inbred BALB C; D009439:Neuraminidase / Q000378:metabolism; D019081:O Antigens / Q000378:metabolism; D014734:Vibrio cholerae / Q000254:growth & development / Q000378:metabolism*
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D019081:O Antigens; C022924:colonization factor antigens; D036781:Fimbriae Proteins; D002772:Cholera Toxin; D009439:Neuraminidase
vernacular_title: Dinamika sinteza protektivnykh antigenov v protsesse glubinnogo kul'tivirovaniia Vibrio cholerae.