Visual electrophysiology in children with tumours affecting the visual pathway. Case reports.
In 9 children (8-14 years of age) with orbital, suprasellar or postchiasmal tumours, visual loss was studied by visual electrophysiology in relation to ophthalmologic and neuroimaging findings. Pattern electroretinography (PERG) and pattern visual evoked potentials (PVEP) to full and half-field pattern-reversal stimulation were recorded and PERG and PVEP changes were related to the tumour location. PERG wave P50 attenuation was found associated with the central retinal dysfunction in the child with orbital rhabdomyosarcoma; PVEP wave P100 delay was associated with the optic nerve dysfunction in a child with retrobulbar chondrosarcoma and in a child with optic nerve glioma; PVEP wave P100 asymmetry was associated with the crossed fibers dysfunction in a child with hypothalamic germinoma, and PVEP wave P100 uncrossed asymmetry was associated with postchiasmal dysfunction in children with postchiasmal tumours (one with pilocytic astrocytoma and two with angioma). On the other hand, normal PERG suggested that there was no central retinal dysfunction in a child with pleomorphic adenoma of the lacrimal gland, and normal PVEP to full and half-field stimulation excluded visual pathway dysfunction at the chiasm in a child with suprasellar arachnoidal cyst. Follow-up was useful in indicating whether visual dysfunction was progressive or not. We conclude that PERG and PVEP findings contributed to understanding whether the dysfunction originated was at the retina, in the optic nerve, chiasm or postchiasmal pathway.
Brecelj
J
J
Institute of Clinical Neurophysiology, University Medical Centre, Ljubljana, Slovenia. jelka.brecelj@kclj.si
Stirn-Kranjc
B
B
Skrbec
M
M
D000293:Adolescent; D002648:Child; D004596:Electroretinography; D005074:Evoked Potentials, Visual; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009897:Optic Chiasm / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D019574:Optic Nerve Neoplasms / Q000175:diagnosis / Q000503:physiopathology*; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000503:physiopathology*; D012160:Retina / Q000503:physiopathology*; D014057:Tomography, X-Ray Computed; D014786:Vision Disorders / Q000175:diagnosis / Q000503:physiopathology*; D014794:Visual Fields; D014795:Visual Pathways / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*