title: Human lung fructose-1,6-bisphosphatase is localized in pneumocytes II.
abstract: The localization of fructose-1,6-bisphosphatase (Fru-1,6-Pase EC 3.1.3.11) in human alveolar epithelium was determined immunohistochemically using a polyclonal antibody raised against the enzyme purified from human liver. The immunohistochemical analysis revealed that the Fru-1,6-Pase was localized in pneumocytes II and was absent in pneumocytes I. Hypothetically Fru-1,6-Pase participating in glucose-6-phosphate synthesis from noncarbohydrate precursors increases NADPH level which is used for surfactant synthesis and for glutathione redox cycle.
authors.affiliation: Department of Animal Physiology, Institute of Zoology, Wroclaw University, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Gizak
authors.forename: D
authors.initials: D
authors.lastname: Rakus
authors.forename: J
authors.initials: J
authors.lastname: Kolodziej
authors.forename: M
authors.initials: M
authors.lastname: Zabel
authors.forename: A
authors.initials: A
authors.lastname: Ogorzalek
authors.forename: A
authors.initials: A
authors.lastname: Dzugaj
mesh_terms: D000818:Animals; D006597:Fructose-Bisphosphatase / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008168:Lung / Q000166:cytology* / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D016612:Paraffin Embedding; D011650:Pulmonary Alveoli / Q000166:cytology / Q000201:enzymology; D011817:Rabbits / Q000276:immunology; D016707:Tissue Fixation
chemical_list: D006597:Fructose-Bisphosphatase