title: A clinical study of root surface conditioning with an EDTA gel. II. Surgical periodontal treatment.
abstract: The objective of the present trial was to assess the effect of an EDTA gel applied during surgical periodontal therapy on probing depth reduction and periodontal attachment gain, allowing for the influence on healing of smoking as well as postsurgical oral hygiene. For comparison, citric acid treatment and control surgery only were included. The investigation was performed in one study center involving one clinical investigator and 68 patients. The patients were selected from a consecutive referral material on a voluntary basis. No statistically significant differences between treatment groups concerning attachment gain or pocket depth reduction could be seen after 3 and 6 months. A subgroup of the sample--21 patients who scored zero on the bleeding index at 3 and 6 months postsurgery and did not smoke--had a borderline significantly higher attachment gain in response to experimental treatment as well as a significant pocket depth reduction 6 months postsurgery when controlling for age, gender, Plaque Index at baseline, and treatment in multiple regression analyses. However, this was true not only for EDTA treatment but for citric acid and control treatment as well.
authors.affiliation: Department of Basic Oral Sciences, School of Dentistry, Karolinska Institute, Box 4064, S-141 04 Huddinge, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Blomlöf
authors.forename: B
authors.initials: B
authors.lastname: Jonsson
authors.forename: J
authors.initials: J
authors.lastname: Blomlöf
authors.forename: S
authors.initials: S
authors.lastname: Lindskog
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002614:Chelating Agents / Q000627:therapeutic use*; D002908:Chronic Disease; D019343:Citric Acid / Q000627:therapeutic use; D003774:Dental Plaque Index; D004492:Edetic Acid / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D005782:Gels; D005884:Gingival Hemorrhage / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009910:Oral Hygiene; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D010518:Periodontitis / Q000601:surgery*; D012017:Referral and Consultation; D012044:Regression Analysis; D012907:Smoking; D014092:Tooth Root / Q000187:drug effects*; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D002614:Chelating Agents; D005782:Gels; D019343:Citric Acid; D004492:Edetic Acid