Covalently bonded polysaccharide derivatives as chiral stationary phases in high-performance liquid chromatography.
Polysaccharide derivatives have been extensively used as chromatographic chiral selectors in chiral stationary phases (CSPs) for the separation of enantiomers by HPLC. When coated onto a silica matrix, they represent nowadays one of the most popular type of CSPs. However, they are only compatible with a limited choice of solvents. The main drawback of these CSPs is related to the solubility of the chiral selector in a number of solvents, which limits their applicability. The different attempts which have been described up to now to overcome this problem by covalently fixing the chiral selector to a matrix are reviewed in this paper.
Franco
P
P
Laboratori de Química Farmacèutica, Facultat de Farmàcia, Universitat de Barcelona, Spain.
Senso
A
A
Oliveros
L
L
Minguillón
C
C
D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation*; D011134:Polysaccharides / Q000737:chemistry*
D011134:Polysaccharides