Oxidative metabolism.
There is a large body of evidence showing both metabolic defects and oxidative damage in Alzheimer's disease. Studies of cybrid cell lines show reduced cytochrome oxidase. There is also substantial evidence for a defect in alpha-ketoglutarate dehydrogenase. It is therefore possible that therapeutic strategies to improve brain metabolism or ameliorate oxidative damage might be useful in treating Alzheimer's disease.
Beal
M F
MF
Department of Neurology and Neuroscience, Weill Medical College of Cornell University and New York Presbyterian Hospital, 525 East 68th Street, Room F610, New York, New York 10021, USA. fbeal@mail.med.cornell.edu
D000544:Alzheimer Disease / Q000378:metabolism*; D001921:Brain / Q000201:enzymology*; D003576:Electron Transport Complex IV / Q000378:metabolism*; D006801:Humans; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism*; D018384:Oxidative Stress / Q000502:physiology
D007655:Ketoglutarate Dehydrogenase Complex; D003576:Electron Transport Complex IV