[Role of somatostatins in the preventin of pancreatic fistulae and the treatment of digestive fistulae].
Somatostatin and analogues exert an extraordinary range of inhibitory effects which eventually may have a variety of therapeutic applications. Treatment of intestinal and pancreatic fistula are the main targets in general and digestive surgery. The perioperative and prophylactic application of somatostatin or octreotide in patients who undergo major pancreatic surgery reduces the postoperative complication rate. This prevention seems indicated following Whipple procedure in patients with soft pancreatic tissue. The efficacy of somatostatin or analogues in the treatment of intestinal or pancreatic fistulae is still in debate. Fistula output frequently decreases but closure rate, healing time and complications rate are not reduced. The treatment and care of patients with high output fistulae may be simplified by somatostatin or analogues if a positive effect on output is obvious in the first days of treatment.
Sales
J P
JP
Service de chirurgie générale, CHU de Bicêtre, 78, rue du Général-Leclerc, 94270 Le Kremlin Bicêtre, France. jean-patrick.sales@bct.ap-hop-paris.fr
Gayral
F
F
D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007412:Intestinal Fistula / Q000188:drug therapy*; D010185:Pancreatic Fistula / Q000517:prevention & control*; D013004:Somatostatin / Q000627:therapeutic use*
D006728:Hormones; D013004:Somatostatin
Place des somatostatines dans la prévention des fistules pancréatiques et le traitement des fistules digestives.