title: CD45/isotypes expression in the immune cells of human periapical lesions.
abstract: Expression of some leukocyte antigens (including CD45) and its isoforms (CD2, CD4, CD5, CD6, CD7, and CD8) was examined in the human periapical granulation tissue samples in the present study. The majority of the infiltrating cells expressed heavy molecular-weight isoforms of the CD45 antigen. Expression of CD2, CD5, CD6, and CD7 antigens was also detected, implying significant roles for these antigens in the immune reaction taking place in periapical lesions. This suggests that the immune response taking place at the periapical region is predominantly cellular and the humoral responses to antigenic challenge are conducted mainly by regional lymph nodes.
authors.affiliation: Hacettepe University, Faculty of Dentistry, Department of Endodontics, (06100) Sihhiye, Ankara, Turkey.
authors.forename: F
authors.initials: F
authors.lastname: Taşman
authors.forename: N
authors.initials: N
authors.lastname: Er
authors.forename: A
authors.initials: A
authors.lastname: Ataç
authors.forename: A
authors.initials: A
authors.lastname: Dağdeviren
authors.forename: B
authors.initials: B
authors.lastname: Kendir
mesh_terms: D000917:Antibody Formation / Q000276:immunology; D015703:Antigens, CD / Q000032:analysis / Q000235:genetics; D019011:Antigens, CD7 / Q000032:analysis / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis / Q000235:genetics; D018801:CD2 Antigens / Q000032:analysis / Q000235:genetics; D015704:CD4 Antigens / Q000032:analysis / Q000235:genetics; D018956:CD5 Antigens / Q000032:analysis / Q000235:genetics; D016827:CD8 Antigens / Q000032:analysis / Q000235:genetics; D005786:Gene Expression Regulation; D006097:Granulation Tissue / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D007132:Immunoglobulin Isotypes / Q000032:analysis; D016130:Immunophenotyping; D017493:Leukocyte Common Antigens / Q000032:analysis / Q000235:genetics*; D008198:Lymph Nodes / Q000276:immunology; D008970:Molecular Weight; D010484:Periapical Granuloma / Q000276:immunology*; D010486:Periapical Tissue / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
chemical_list: D015703:Antigens, CD; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte; D018801:CD2 Antigens; D015704:CD4 Antigens; D018956:CD5 Antigens; C062279:CD6 antigen; D016827:CD8 Antigens; D007132:Immunoglobulin Isotypes; D017493:Leukocyte Common Antigens