title: The 2000 Moyer Award. The relevance of base deficits after burn injuries.
abstract: The relevance of an elevated base deficit (BD) during the fluid resuscitation of a thermally injured patient is not completely understood. After nonthermal trauma, early elevation of the BD represents insufficient cellular perfusion and is ultimately associated with a higher incidence of organ dysfunction and death. However, this relationship has not been completely examined after burn injuries. The purpose of this study was to determine if elevation of the BD during burn resuscitation was associated with potential consequences of malperfusion, such as systemic inflammatory response syndrome, acute respiratory distress syndrome, and multiple organ dysfunction. The records of 72 patients with burn injuries (mean age, 46 +/- 17 years; mean total body surface area burned, 44% +/- 18%) who required fluid resuscitation on admission to an adult regional burn center were analyzed. Patients with a mean BD of less than -6 mmol/L during the first 24 hours were compared with patients with a mean BD of more than -6 mmol/L. Despite adequate resuscitation with good maintenance of urinary output, the patients in the group with a mean BD of less than -6 mmol/L had more florid systemic inflammatory response syndrome (P = .004), had more prevalent acute respiratory distress syndrome (P = .012), and experienced more severe multiple organ dysfunction (P < .001) compared with patients in the group with a mean BD of more than -6 mmol/L. The results suggest that abnormal elevation of the BD after burn injuries represents a malperfusion state, which may not be recognized if only "traditional" parameters, such as UO, are followed. Furthermore, this state appears to be related to the onset of more severe systemic inflammation and organ dysfunction.
authors.affiliation: Ross Tilley Burn Center, Sunnybrook and Women's College Health Sciences Centre, Toronto, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Choi
authors.forename: A
authors.initials: A
authors.lastname: Cooper
authors.forename: M
authors.initials: M
authors.lastname: Gomez
authors.forename: J
authors.initials: J
authors.lastname: Fish
authors.forename: R
authors.initials: R
authors.lastname: Cartotto
mesh_terms: D000138:Acidosis / Q000097:blood*; D000328:Adult; D001363:Awards and Prizes; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D002056:Burns / Q000097:blood / Q000150:complications* / Q000628:therapy; D005260:Female; D005440:Fluid Therapy; D006439:Hemodynamics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007249:Inflammation; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000209:etiology; D011379:Prognosis; D012016:Reference Values; D012128:Respiratory Distress Syndrome / Q000209:etiology
chemical_list: D015415:Biomarkers