title: Pharmacokinetics of naratriptan in adolescent subjects with a history of migraine.
abstract: Naratriptan is a novel 5-HT1 agonist developed to treat acute migraine. The study objective was to characterize the pharmacokinetics of oral naratriptan in adolescent migraine patients outside a migraine attack. Subjects received a single 2.5 mg naratriptan tablet. Serial serum samples for naratriptan concentrations were collected over 24 hours. Blood pressure, pulse rate, and 12-lead ECG were recorded at baseline and at regular intervals after dosing. Seven patients--3 males and 4 females, 12 to 16 years of age--received drug and completed the study. The geometric mean and 95% confidence interval maximum concentration (Cmax) was 8.0 ng/mL (5.9-10.7), elimination half-life (t1/2) was 4.9 hours (4.5-5.4), area under the concentration-time curve (AUC) was 74.6 ng.h/mL (56.6-98.2), and apparent total clearance (Cl/F) was 558.8 mL/min (424.3-735.9). The median time to maximal concentration (tmax) was 4 hours, with a range of 1.5 to 4. Blood pressure, pulse rate, and ECG parameters did not change significantly from baseline. No serious adverse events or subject withdrawal after drug administration occurred. Oral naratriptan pharmacokinetic parameters in adolescents were similar to values reported in adults. Naratriptan doses for adolescents older than 12 years of age would be expected to be similar to adult doses.
authors.affiliation: Department of Clinical Pharmacy, Pediatric Pharmacology Research Unit, Center for Pediatric Pharmacokinetics and Therapeutics, University of Tennessee, Memphis 38163, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Christensen
authors.forename: S K
authors.initials: SK
authors.lastname: Eades
authors.forename: E
authors.initials: E
authors.lastname: Fuseau
authors.forename: R D
authors.initials: RD
authors.lastname: Kempsford
authors.forename: S J
authors.initials: SJ
authors.lastname: Phelps
authors.forename: L J
authors.initials: LJ
authors.lastname: Hak
mesh_terms: D000293:Adolescent; D019540:Area Under Curve; D002648:Child; D005260:Female; D006801:Humans; D007211:Indoles / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy / Q000378:metabolism*; D010880:Piperidines / Q000493:pharmacokinetics* / Q000627:therapeutic use; D017366:Serotonin Receptor Agonists / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014363:Tryptamines
chemical_list: D007211:Indoles; D010880:Piperidines; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C106783:naratriptan