Immunohistochemical nuclear staining for P53 in nodular scabies.
Fifty patients with scabies were included in this study. Clinical, parasitological and histopathological study of all patients was done. P-53 expression was examined, using immunohistochemical techniques. Biopsies of nodular scabies showed atypical changes in the epidermis, the dermis showed dense inflammatory infiltrate. Focal positivity for P-53 have been demonstrated which could favour premalignant changes, and recommend further investigations.
Mohammad
M M
MM
Department of Parasitology, Dermatology and Venereology and Pathology, Faculty of Medicine for Girls, Al-Azhar University, Nasr City, Cairo, Egypt.
Ali
M M
MM
Aidarous
H M
HM
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D008875:Middle Aged; D012532:Scabies / Q000473:pathology*; D012867:Skin / Q000473:pathology; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D016159:Tumor Suppressor Protein p53