title: [Clinical effect and tolerance of paxil (paroxetine) in management of panic disorders].
abstract: OBJECTIVE
  To determine clinical efficiency and tolerance of paxil (paroxetin) in the treatment of panic disorders.
  
  
  METHODS
  An open, non-comparative 7 week study entered 60 patients (mean age 36.6 +/- 3.22 years) with panic disorders and agoraphobias with panic disorders. Paroxetin was given in a single daily dose 20-60 mg/day in the morning. The results were assessed by Hamilton and Sihan scales, scale of clinical impression, by reduction of panic attacks.
  
  
  RESULTS
  In 72.2% of patients panic attacks ceased or occurred less frequently (by 50%). Anxiety relieved by 67 +/- 4.6%. The number of the responders was greater while the effect occurred faster in patients with panic disorders. The drug was well tolerated, side effects occurred in 43.3% of cases. They were mild or moderate.
  
  
  CONCLUSIONS
  Paroxetin has a prominent anxiolytic and antiphobic action, is well tolerated and is effective in panic disorders and agoraphobia with panic disorders.
authors.forename: S N
authors.initials: SN
authors.lastname: Mosolov
authors.forename: A B
authors.initials: AB
authors.lastname: Smulevich
authors.forename: Iu L
authors.initials: IuL
authors.lastname: Nuller
authors.forename: V S
authors.initials: VS
authors.lastname: Grigor'evskikh
authors.forename: E G
authors.initials: EG
authors.lastname: Kostiukova
authors.forename: M V
authors.initials: MV
authors.lastname: Kuzavkova
authors.forename: E V
authors.initials: EV
authors.lastname: Koliutskaia
authors.forename: A V
authors.initials: AV
authors.lastname: Andriushchenko
authors.forename: E V
authors.initials: EV
authors.lastname: Zelenina
authors.forename: V P
authors.initials: VP
authors.lastname: Kosinskiĭ
authors.forename: V L
authors.initials: VL
authors.lastname: Kozlovskiĭ
authors.forename: S I
authors.initials: SI
authors.lastname: Bykov
authors.forename: I G
authors.initials: IG
authors.lastname: Pererva
mesh_terms: D000328:Adult; D000379:Agoraphobia / Q000188:drug therapy; D018687:Antidepressive Agents, Second-Generation / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000188:drug therapy*; D017374:Paroxetine / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D017374:Paroxetine
vernacular_title: Klinicheskaia éffektivnost' i perenosimost' paksila (paroksetina) pri lechenii panicheskogo rasstroĭstva.