title: 3,28-Di-O-(dimethylsuccinyl)-betulin isomers as anti-HIV agents.
abstract: Four isomers of 3,28-di-O-(dimethylsuccinyl)-betulin were prepared and evaluated for anti-HIV activity against HIV-1 replication in H9 lymphocyte cells. 3-O-(3',3'-Dimethylsuccinyl)-28-O-(2", 2"-dimethvlsuccinyl)-betulin (11) was the most potent anti-HIV compound with an EC5, value of 0.00087 microM and a TI value of 42,400.
authors.affiliation: Niigata College of Pharmacy, Japan. kasiwada@niigata-pharm.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Kashiwada
authors.forename: J
authors.initials: J
authors.lastname: Chiyo
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeshiro
authors.forename: T
authors.initials: T
authors.lastname: Nagao
authors.forename: H
authors.initials: H
authors.lastname: Okabe
authors.forename: L M
authors.initials: LM
authors.lastname: Cosentino
authors.forename: K
authors.initials: K
authors.lastname: Fowke
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D020650:Combinatorial Chemistry Techniques; D015497:HIV-1 / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D020128:Inhibitory Concentration 50; D007536:Isomerism; D008214:Lymphocytes / Q000821:virology; D013329:Structure-Activity Relationship; D019802:Succinic Acid / Q000737:chemistry; D013810:Therapeutic Equivalency; D014315:Triterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000094062:Betulinic Acid
chemical_list: D019380:Anti-HIV Agents; D019802:Succinic Acid; D014315:Triterpenes; C002503:betulin; D000094062:Betulinic Acid