Antimycobacterial in vitro activity of cobalt(II) isonicotinoylhydrazone complexes. Part 10.
Octahedral cobalt(II) complexes of isonicotinoylhydrazones, which were obtained from the primary antituberculous agent isoniazid, have been synthesised and characterised. Their antimycobacterial in vitro activity has been evaluated against Mycobacterium tuberculosis H37Rv: they exhibit MIC values ranging from < 0.1 to 0.39 microg/mL, showing them to be generally more active than previously reported analogous Cu(II) and Ni(II) complexes.
Bottari
B
B
Dipartimento Farmaco-chimico, Facoltà di Farmacia, Università di Messina, Italy.
Maccari
R
R
Monforte
F
F
Ottanà
R
R
Rotondo
E
E
Vigorita
M G
MG
D000818:Animals; D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002522:Chlorocebus aethiops; D003035:Cobalt / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D004355:Drug Stability; D008024:Ligands; D008826:Microbial Sensitivity Tests; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014709:Vero Cells
D000995:Antitubercular Agents; D008024:Ligands; D009942:Organometallic Compounds; D003035:Cobalt