title: Serum KL-6 as a possible marker for amiodarone-induced pulmonary toxicity.
abstract: Amiodarone is a useful drug for the treatment of life-threatening cardiac arrhythmias. However, amiodarone can induced pulmonary toxicity (APT) and may cause life-threatening lung damage. APT can be difficult to diagnose, but early diagnosis is important. Here, in a 51-year-old man with APT, the high serum KL-6 level was correlated with the severity of symptoms and chest X-ray findings, and it was inversely correlated with PaO2 and diffusion capacity for carbon monoxide levels. The findings suggest that the serum KL-6 level may be increased in APT and that therefore it's the determination of serum KL-6 may provide a useful indicator and/or monitoring marker of APT. KL-6 is believed to be produced and secreted by type II pneumocytes. Typical pathological findings of APT include proliferation of type II pneumocytes which may produce KL-6, and result in increased serum KL-6 levels.
authors.affiliation: Department of Medicine, Kawasaki Medical School, Kurashiki.
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: Y
authors.initials: Y
authors.lastname: Kawahara
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: N
authors.initials: N
authors.lastname: Miyashita
authors.forename: Y
authors.initials: Y
authors.lastname: Niki
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
mesh_terms: D000638:Amiodarone / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000941:Antigens / Q000097:blood*; D000951:Antigens, Neoplasm; D015415:Biomarkers / Q000097:blood; D002248:Carbon Monoxide / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000188:drug therapy; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D017563:Lung Diseases, Interstitial / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D014057:Tomography, X-Ray Computed; D018879:Ventricular Premature Complexes / Q000188:drug therapy
chemical_list: D000889:Anti-Arrhythmia Agents; D000941:Antigens; D000951:Antigens, Neoplasm; D015415:Biomarkers; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D002248:Carbon Monoxide; D000638:Amiodarone; D010100:Oxygen