Dendritic and cancer cells in the breast tumors--an immunohistochemical study: short communication.
Normal and dysplastic mammary glands express immunocompetent S-100 protein positive dendritic cells (DCs), which are located in a regular pattern, in the suprabasal cell layer of the ducts and alveolar nodules. The epithelial cells, however, are S-100 protein negative. Since some breast cancers also express the S-100 protein, our aim was to check the diagnostic and prognostic value of the S-100 protein distribution combined with the tumor grade and expression of synaptophysin (Syn), chromogranin A (Chg A), c-erbB-2 oncoprotein and p53 protein in infiltrating and metastatic breast tumors. Applying immunohistochemical methods, we show in paraffin- or frozen breast tissue sections that in some cases of the infiltrating breast carcinomas, S-100 protein positive cells do not appear, whereas in other cases, either S-100 protein positive DCs are closely associated with cancer cells, or the cancer cells themselves stain positive to S-100 protein. However, we found no correlation between the S-100 protein expression and other investigated parameters.
Lewko
B
B
Department of Immunopathology, Medical University, ul, Debinki 7, 80-211 Gdańsk, Poland. blew@amedec.amg.gda.pl
Zółtowska
A
A
Stepiński
J
J
Roszkiewicz
A
A
Moszkowska
G
G
D001940:Breast / Q000166:cytology / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D016022:Case-Control Studies; D053379:Chromogranin A; D002864:Chromogranins / Q000378:metabolism; D003713:Dendritic Cells / Q000378:metabolism* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism
D053379:Chromogranin A; D002864:Chromogranins; D018719:Erb-b2 Receptor Tyrosine Kinases; D009418:S100 Proteins; D016708:Synaptophysin; D016159:Tumor Suppressor Protein p53