[Tramadol and oxazepam. Effect on pulmonry function in elderly patients with chronic obstructive lung disease].
Many patients with chronic obstructive pulmonary disease (COPD) suffer from osteoporotic pain as a result of glucocorticoid treatment and nervous symptoms partly related to their lung disease. There seems to be som reluctance to treat these patients with an opioid or benzodiazepine. Upon request, the Drug Information Centre in Odense made an extensive literature search on the subject. No documentation was found that tramadol additionally depresses the respiration in patients with COPD, nor has oxazepam in clinically relevant doses been found to exacerbate their lung disease. The clinical effect is subject to large interindividual variability, and the use of these drugs should, to a greater extent, rest on experience with the individual patient. There seems to be no reason to maintain a priori this rigoristic reluctance to use tramadol and/or oxazepam in patients with COPD.
Larsen
J
J
Institut for Sundhedstjenesteforskning, afdeling for klinisk farmakologi og Forskningsenheden for Almen Medicin, Syddansk Universitet, Odense. j-larsen@cekfo.sdu.dk
Arnberg
A
A
Brøsen
K
K
D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage* / Q000009:adverse effects; D014151:Anti-Anxiety Agents / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D010076:Oxazepam / Q000008:administration & dosage* / Q000009:adverse effects; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000009:adverse effects / Q000737:chemistry; D012119:Respiration / Q000187:drug effects*; D014147:Tramadol / Q000008:administration & dosage* / Q000009:adverse effects
D000701:Analgesics, Opioid; D014151:Anti-Anxiety Agents; D010975:Platelet Aggregation Inhibitors; D014147:Tramadol; D010076:Oxazepam
Tramadol og oxazepam. Effekt på lungefunktionen hos aeldre patienter med kronisk obstruktiv lungesygdom.