Uptake of the 188Re(V)-DMSA complex by cervical carcinoma cells in nude mice: pharmacokinetics and dosimetry.
The uptake of the rhenium-188 (188Re(V)-DMSA) complex of dimercaptosuccinic acid by cervical carcinoma cells in nude mice was evaluated. The pharmacokinetics and dosimetry calculations in normal rats were also evaluated. The images obtained in mice did not show significant accumulation in metabolic organs and the biodistribution studies showed that 3.52 +/- 0.76% of the injected activity per gram (n = 4) was taken up by the tumor. This percentage produces a cumulated activity of 35.63 +/- 8.40 MBq h and an equivalent dose per injected activity of 260 +/- 8.91 mSv/MBq. Pharmacokinetics and dosimetry of the 1887e(V)-DMSA complex indicate that this radiopharmaceutical could be evaluated in patients with soft tissue tumors, since the risk of radiation damage to the kidney or red bone marrow could not be an obstacle for its application in therapeutic nuclear medicine.
García-Salinas
L
L
Departamento de Materiales Radiactivos, Instituto Nacional de Investigaciones Nucleares, Salazar, Estado de México, Mexico.
Ferro-Flores
G
G
Arteaga-Murphy
C
C
Pedraza-López
M
M
Hernández-Gutiérrez
S
S
Azorin-Nieto
J
J
D000818:Animals; D005260:Female; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D011829:Radiation Dosage; D011868:Radioisotopes / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019275:Radiopharmaceuticals / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D012211:Rhenium / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004113:Succimer / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D014018:Tissue Distribution; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000532:radiotherapy*
D009942:Organometallic Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals; C069609:rhenium(V)dimercaptosuccinic acid; D012211:Rhenium; D004113:Succimer