Anticonvulsant and behavioral actions of triterpene isolated from Rubia cordifolia Linn.
Effect of a triterpene isolated from the acetone soluble part of petroleum ether extract of R. cordifolia was studied on convulsions induced by maximum electro shock (MES), electrical kindling and various chemoconvulsants in rats and mice. The effect of triterpene was also investigated on behavior and gamma-aminobutyric acid (GABA) and serotonin (5-HT) content in mouse brain. Triterpene inhibited seizures induced by MES, electrical kindling, pentylenetetrazol (PTZ), and lithium-pilocarpine. However, seizures induced by strychnine were not inhibited. Triterpene reduced locomotion as well as rearing. Pentobarbitone induced sleep was potentiated and amphetamine induced stereotypy was inhibited. The triterpene was found to possess anxiogenic activity. Brain GABA and 5-HT contents were raised by the compound. The study suggests that the triterpene isolated from R. cordifolia bear a potential for further study.
Kasture
V S
VS
M.V.P. Samaj's College of Pharmacy, Gangapur Road, Nashik 422 002, India.
Deshmukh
V K
VK
Chopde
C T
CT
D000818:Animals; D000927:Anticonvulsants / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D019666:Rubiaceae / Q000737:chemistry*; D012701:Serotonin / Q000378:metabolism; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000927:Anticonvulsants; D014315:Triterpenes; D012701:Serotonin; D005680:gamma-Aminobutyric Acid