title: Effect of enrofloxacin-Na against pathogens related to the respiratory and alimentary diseases in suckling and weanling piglets.
abstract: A field trial was conducted to evaluate effect of enrofloxacin-Na against pathogens related to the respiratory and alimentary diseases in eighty suckling piglets (6-7 days old) and eighty weanling piglets (5-6 weeks old). Respective twenty of the suckling and weanling piglets were assigned to each of 4 experimental groups; control (non-treated), clinical injection dose (CID), 2x clinical injection dose (2CID). and premix. A 0.05 ml (2.5 mg) of enrofloxacin-Na injection (5% solution, 1 ml) per kg body weight of piglets as CID was injected intramuscularly for 3 days and the clinical signs were observed for 9 days. The premix (150 ppm) of enrofloxacin-Na was administered with feed for 7 days ad libitum and the clinical signs were observed for 13 days. The enrofloxacin-Na-treated piglets showed a higher increase in body weight and a lower feed per gain than the control piglets. In addition, the treatment of enrofloxacin-Na, regardless of the route of administration, decreased the incidence rate of diarrhea in suckling piglets and respiratory symptoms in weanling piglets. The isolation index of E. coli and Cl. perfringens during the treatment periods was also lowered by the enrofloxacin-Na treatment in both suckling and weanling piglets. The antibiotics was also evaluated as safe locally and whole bodily as treated by injection or feeding. These results indicate that the newly developed antibiotics, enrofloxacin-Na, is very useful for the prevention and therapy of swine diseases in the pig industry.
authors.affiliation: College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Suwon, Korea.
authors.forename: H S
authors.initials: HS
authors.lastname: Yoo
authors.forename: B J
authors.initials: BJ
authors.lastname: Lee
authors.forename: B S
authors.initials: BS
authors.lastname: Chang
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
authors.forename: B K
authors.initials: BK
authors.lastname: Park
mesh_terms: D000818:Animals; D000833:Animals, Suckling; D000890:Anti-Infective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D019072:Antibiotic Prophylaxis / Q000662:veterinary*; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000517:prevention & control / Q000662:veterinary*; D004066:Digestive System Diseases / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D000077422:Enrofloxacin; D024841:Fluoroquinolones; D008826:Microbial Sensitivity Tests / Q000662:veterinary*; D015363:Quinolones / Q000494:pharmacology* / Q000627:therapeutic use; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*; D014886:Weaning
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D000077422:Enrofloxacin