title: Structure-activity relationships for the analgesic activity of gallic acid derivatives.
abstract: Values of ID50 for a collection of structurally-related gallic acid derivatives have been employed to create a predictive quantitative structure-activity relationship (QSAR) which links structure to values of analgesic activity. The QSAR model developed has substantial predictive power for the design of novel gallic acid derivatives having improved analgesic potency.
authors.affiliation: College of Pharmacy, University of Michigan, Ann Arbor 48109, USA.
authors.forename: R
authors.initials: R
authors.lastname: Krogh
authors.forename: R A
authors.initials: RA
authors.lastname: Yunes
authors.forename: A D
authors.initials: AD
authors.lastname: Andricopulo
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D051379:Mice; D015233:Models, Statistical; D010147:Pain Measurement / Q000187:drug effects; D021281:Quantitative Structure-Activity Relationship
chemical_list: D018712:Analgesics, Non-Narcotic; D005707:Gallic Acid