[Effect of bifidobacteria and lactobacillus and antibiotics in combination with common gnotobiological isolation on the survival of mice with acute radiation sickness].
The influence of the combined use of bacterial preparations (Bifidobacterium and Lactobacillus) and antibiotics (ciprofloxacin, lomefloxacin and amikacin) on the survival rate of irradiated mice placed under the conditions of general gnotobiological isolation was studied. Bacterial strains used in combination with quinolones (ciprofloxacin, lomefloxacin) significantly increased the mean survival time of the animals (p < 0.05) when introduced in a dose of 1.0 x 10(9) microbial cells per mouse on days 1, 3, 5, 7, 9, 11, 13 and 15 after irradiation. At the same time a short course of treatment with bacterial preparations (two injections on days 5 and 7 after irradiation) proved to be insufficient for increasing the survival rate of the animals. The mean survival time of the irradiated mice was higher after the use of bacterial preparations in combination with lomefloxacin or ciprofloxacin than after their use with amikacin.
Pikina
A P
AP
State Medical University, Institute of Medico-Social Rehabilitology, Moscow, Russia.
Efimov
B A
BA
Smeianov
V V
VV
Baĭnov
N A
NA
Brook
I
I
Reeves
G
G
Korshumov
V M
VM
D000208:Acute Disease; D000583:Amikacin / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use; D001644:Bifidobacterium; D002939:Ciprofloxacin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D024841:Fluoroquinolones; D005856:Germ-Free Life; D007778:Lactobacillus; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D019936:Probiotics / Q000627:therapeutic use*; D015363:Quinolones / Q000627:therapeutic use; D011832:Radiation Injuries / Q000188:drug therapy / Q000401:mortality / Q000628:therapy*; D015996:Survival Rate
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D002939:Ciprofloxacin; D000583:Amikacin; C053091:lomefloxacin
Vliianie na vyzhivaemost' mysheĭ pri ostroĭ luchevoĭ bolezni bifido- i laktobakteriĭ i antibiotikov v komplekse s obshcheĭ gnotobiologicheskoĭ izoliatsieĭ.