Acyclovir-resistant varicella infection with atypical lesions in a non-HIV leukemic infant.
An HIV-negative infant presented with VZV primary infection during the maintenance therapy for megakaryoblastic leukaemia. The lesions were initially vesicular and necrotic but became verrucous and hyperkeratotic. A clinical resistance to acyclovir was suspected and confirmed by histologic and virologic studies. The patient was successfully treated by foscarnet.


CONCLUSIONS
resistance of VZV to acyclovir may occur after a short treatment in a non-AIDS patient.
Crassard
N
N
Department of Pediatric Hematology and Immunology, H pital Debrousse, Lyon, France.
Souillet
A L
AL
Morfin
F
F
Thouvenot
D
D
Claudy
A
A
Bertrand
Y
Y
D000212:Acyclovir / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002644:Chickenpox / Q000175:diagnosis*; D004351:Drug Resistance; D017245:Foscarnet / Q000627:therapeutic use*; D018023:HIV Seronegativity; D014645:Herpesvirus 3, Human / Q000187:drug effects / Q000302:isolation & purification*; D006801:Humans; D007223:Infant; D007947:Leukemia, Megakaryoblastic, Acute / Q000188:drug therapy*; D008297:Male; D008826:Microbial Sensitivity Tests; D012044:Regression Analysis
D000998:Antiviral Agents; D017245:Foscarnet; D000212:Acyclovir