title: [Immunosuppressive components of extracellular polysaccharide from Pseudomonas aeruginosa clinical strains].
abstract: The immunosuppressive activity of lipopolysaccharide (LPS) contained in filtrates of newly isolated P. aeruginosa cultures was studied. The experimental model of delayed hypersensitivity to non-bacterial antigen in CBA mice and gel filtration through Sephadex G-200 were used. In addition to the already known LPS component with direct immunosuppressive action and having a mol.wt. of 150-800 kD, a new component was detected. It was found to be in inactive state and could be activated by redox treatment, thus becoming capable of inducing capacity for immunosuppression in Escherichia coli. This component had a mol.wt. of 50-70 kD and lost its activity after heating.
authors.affiliation: Gromashevsky Research Institute of Epidemiology and Infectious Diseases, Kiev, Ukraine.
authors.forename: E V
authors.initials: EV
authors.lastname: Borisova
mesh_terms: D000818:Animals; D002850:Chromatography, Gel; D004926:Escherichia coli / Q000187:drug effects / Q000276:immunology; D005110:Extracellular Space / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology* / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D010084:Oxidation-Reduction; D011550:Pseudomonas aeruginosa / Q000276:immunology* / Q000302:isolation & purification
chemical_list: D008070:Lipopolysaccharides
vernacular_title: Immunosupressivnye komponenty ékstratselliuliarnogo lipopolisakharida klinicheskikh shtammov Pseudomonas aeruginosa.