[Improving a process of cultivation of bifidobacteria in a bioreactor to obtain lyophilized seed culture].
The parameters of the cultivation process and the characteristics of the culture growth have been analyzed. The phases of the population growth have been determined. The existence of short stages differing in the physiological state of the cells, their resistance to damaging factors and metabolic activity within the deceleration phase of the growth of bifidobacteria has been experimentally substantiated. To harvest the biomass, the period of the completion of the cultivation process has been chosen. The lyophilized seed culture in which a high percentage of viable cells is preserved for one year has been obtained.
Murashova
A O
AO
Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.
Lanskikh
A G
AG
Basnak'ian
I A
IA
D001644:Bifidobacterium / Q000254:growth & development*; D019149:Bioreactors; D005612:Freeze Drying
Usovershenstvovanie protsessa vyrashchivaniia bifidobakteriĭ v bioreaktore dlia polucheniia liofilizirovannoĭ posevnoĭ kul'tury.