title: Differences in left ventricular response between rheumatic and myxomatous mitral valve disease following mitral valve replacement.
abstract: OBJECTIVE
  We studied whether differences exist between hearts having rheumatic mitral valves and those having myxomatous mitral valves, in functional, geometrical, and mass changes in the left ventricle after mitral valve replacement.
  
  
  METHODS
  Patients who underwent mitral valve replacement without preservation of annular-papillary continuity for pure mitral incompetence were classified into rheumatic and myxomatous based on valvular histopathology. Echographic data measured before surgery was compared to that about 3 weeks after surgery.
  
  
  RESULTS
  In the rheumatic group, ejection fraction decreased from 57.5 +/- 10.8 to 47.7 +/- 12.0, indexed left ventricular internal dimension in systole (mm/m2) from 24.7 +/- 6.8 to 20.7 +/- 6.2 (P = 0.0001), and left ventricular mass index (g/m2) from 205 +/- 55 to 138 +/- 54 (P = 0.0002). In the myxomatous group, ejection fraction decreased from 60.4 +/- 11.6 to 39.7 +/- 14.5 (P = 0.0001), indexed left ventricular internal dimension in systole from 24.2 +/- 5.6 to 23.1 +/- 5.5, and left ventricular mass index from 195 +/- 83 to 111 +/- 72 (P = 0.0004). Mean wall thickness index and relative wall thickness showed significant differences between the two groups postoperatively but no significant difference preoperatively.
  
  
  CONCLUSIONS
  Hearts dilated due to chronic mitral incompetence respond differently after valvular replacement with total chordal excision depending on whether a rheumatic or myxomatous mitral valve is involved.
authors.affiliation: Department of Cardiovascular Surgery, National Cardiovascular Center, Osaka, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakayama
authors.forename: C
authors.initials: C
authors.lastname: Yutani
authors.forename: M
authors.initials: M
authors.lastname: Imakita
authors.forename: H
authors.initials: H
authors.lastname: Ishibashi-Ueda
authors.forename: Y
authors.initials: Y
authors.lastname: Kosakai
authors.forename: N
authors.initials: N
authors.lastname: Nakajima
mesh_terms: D002815:Chordae Tendineae / Q000601:surgery; D019918:Heart Valve Prosthesis Implantation; D006801:Humans; D008943:Mitral Valve / Q000601:surgery*; D008944:Mitral Valve Insufficiency / Q000473:pathology / Q000503:physiopathology*; D008945:Mitral Valve Prolapse / Q000503:physiopathology; D012189:Retrospective Studies; D012214:Rheumatic Heart Disease / Q000473:pathology / Q000503:physiopathology*; D016277:Ventricular Function, Left; D020257:Ventricular Remodeling