[Ultrastructural changes in the pancreas of rats with acute pancreatitis after semax administration].
Semax favorably affects ultrastructural changes in the pancreas of rats with acute pancreatitis (AP): a single introduction of semax (0.1 mg/kg) into the pancreatic duct of rats with AP model prevents increased necrosis of the acinar tissues and inhibits purulent inflammation of the necrotised lobules by inducing their sclerosis and atrophy, thus retaining large areas of the pancreas intact.
Ivanov
Iu V
IuV
Department of Pharmacology, Gidrobios Research and Production Center, Ministry of Public Health of the Russian Federation, ul. Kosmonavtov 18 (korp. 2), Moscow, 129301 Russia.
D000208:Acute Disease; D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D000818:Animals; D001284:Atrophy; D008297:Male; D008854:Microscopy, Electron; D009336:Necrosis; D018697:Nootropic Agents / Q000627:therapeutic use*; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D010195:Pancreatitis / Q000188:drug therapy* / Q000473:pathology; D010446:Peptide Fragments / Q000627:therapeutic use*; D051381:Rats; D012598:Sclerosis
D018697:Nootropic Agents; D010446:Peptide Fragments; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone
Ul'trastrukturnye izmeneniia v podzheludochnoĭ zheleze krys s ostrym pankreatitom posle vvedeniia semaksa.