title: One-month-old infant with multiple ulcers of stomach, small bowel, large bowel, and protein-losing enteropathy: case report.
abstract: Multiple inflammatory ulcers of the gastrointestinal tract are rare in young infants. Most cases are caused by infectious organisms, vasculitis, or an autoimmune process. We report a 1-month-old infant who was healthy until he presented with an inflammatory mesenteric cyst, and multiple ulcers of the stomach, duodenum, jejunum, ileum, and colon. Histologically, the ulcerations were sharply demarcated, full thickness, and filled with macrophages. He had a low serum albumin and IgG due to protein-losing enteropathy. He was treated with supportive care and immunomodulating drugs. The gastrointestinal inflammation resolved by 3 and 1/2 years of age. The medications were withdrawn at 5 and 1/2 years of age he had no relapse of clinical symptoms. He continues to have asymptomatic mild hypoalbuminemia and low serum IgG. We could not find a report of a similar clinical presentation and outcome.
authors.affiliation: Department of Pediatrics, University of Louisville, KY 40202, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Stephen
authors.forename: R W
authors.initials: RW
authors.lastname: Bendon
mesh_terms: D000418:Albumins / Q000032:analysis; D004359:Drug Therapy, Combination; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007410:Intestinal Diseases / Q000097:blood / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D007420:Intestine, Large / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*; D008297:Male; D011504:Protein-Losing Enteropathies / Q000097:blood / Q000150:complications / Q000473:pathology* / Q000628:therapy; D013276:Stomach Ulcer / Q000097:blood / Q000209:etiology / Q000473:pathology* / Q000628:therapy; D014456:Ulcer / Q000097:blood / Q000209:etiology / Q000473:pathology* / Q000628:therapy
chemical_list: D000418:Albumins; D007074:Immunoglobulin G