Levels of complement components, immunoglobulins and acute phase proteins in plasma during aging in Nigeria.
Plasma samples from Nigerians aged 6-95 years were examined for their content of complement components (C3, C4, factor B-Bf), immuloglobins (IgG, IgA, IgM IgD) and acute phase proteins (transferrin, albumin, C-reactive protein--CRP, alpha-2-macroglobulin). Albumin, was estimated colorimetrically and the other components by the single radial immunodiffusion techniques. No significant age-related changes in mean values of the four immunobulins and the four acute phase proteins could be demonstrated. Also, the mean values for C3 and Bf did not change significantly with age but C4 values rose significantly with increasing age (r -0.232: P < 0.01).
Oyeyinka
G O
GO
Department of Chemical Pathology & Immunology, Faculty of Health Sciences, University of Ilorin, Ilorin, Nigeria.
Salimonu
L S
LS
D000209:Acute-Phase Proteins / Q000276:immunology / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000276:immunology; D044383:Black People; D002648:Child; D003124:Colorimetry; D003165:Complement System Proteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood* / Q000276:immunology; D008875:Middle Aged; D009549:Nigeria; D011863:Radioimmunoassay; D012016:Reference Values; D012959:Socioeconomic Factors
D000209:Acute-Phase Proteins; D007136:Immunoglobulins; D003165:Complement System Proteins