title: Type A botulinum toxin for the treatment of hypertrophy of the masseter and temporal muscles: an alternative treatment.
abstract: The treatment of hypertrophy of the masseter and temporal muscles has to date been dominated by conservative and surgical measures. Local therapy with type A botulinum toxin permits an alternative method of treatment. After targeted, sometimes electromyographically controlled, intramuscular injection of the affected muscles, marked inactivity atrophy occurred in the muscles of seven patients over the course of 3 to 8 weeks. This atrophy remained constant over a follow-up period of up to 25 months, and no side effects were observed. Because of its minimal invasiveness, this technique seems to have an advantage over conventional surgical therapy. Consequently, treatment with type A botulinum toxin can be regarded as a sensible alternative to surgery in cases of hypertrophy of the masseter and/or temporal muscles.
authors.affiliation: Department of Oral and Maxillofacial Surgery, University of Bonn, Germany. vonlindern@mkgchirurg.de
authors.forename: J J
authors.initials: JJ
authors.lastname: von Lindern
authors.forename: B
authors.initials: B
authors.lastname: Niederhagen
authors.forename: T
authors.initials: T
authors.lastname: Appel
authors.forename: S
authors.initials: S
authors.lastname: Bergé
authors.forename: R H
authors.initials: RH
authors.lastname: Reich
mesh_terms: D000293:Adolescent; D000328:Adult; D019274:Botulinum Toxins, Type A / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006984:Hypertrophy; D007273:Injections, Intramuscular; D008297:Male; D008406:Masseter Muscle / Q000187:drug effects / Q000473:pathology*; D008875:Middle Aged; D009122:Muscle Hypertonia / Q000188:drug therapy*; D012008:Recurrence; D019233:Retreatment; D013703:Temporal Muscle / Q000187:drug effects / Q000473:pathology*
chemical_list: D019274:Botulinum Toxins, Type A