[Chemobiokinetics of sarcolysin and its peptides with glutaminic acid].
A 14C study of chemobiokinetics of sarcolysin and its peptides of glutaminic acid, dosage and routes of administration was conducted in intact rats and those bearing Walker's carcinoma. Similar in shape for peptides, kinetic curves differed from those found for sarcolysin. The rates of absorption and excretion of sarcolysin peptides in intraperitoneal and, particularly, oral administration were lower than those of sarcolysin. Tumor appeared to play a role in a higher rate of peptide excretion. While sarcolysin and its peptides distribution in organs and tissues was generally identical, time of peak radioactive concentration build-up was different. Time needed for accumulation and excretion of peptides from tumor was much longer than from other organs or tissues. Sarcolysin went chiefly to urine while peptides--to faeces.
Mironiuk
T A
TA
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Korsakov
M V
MV
Reztsova
V V
VV
Kon'kov
S A
SA
Zhdanova
E A
EA
Krasnov
V P
VP
Filov
V A
VA
D000284:Administration, Oral; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002250:Carbon Radioisotopes; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D004334:Drug Administration Schedule; D005971:Glutamates / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D007263:Infusions, Parenteral; D008297:Male; D008558:Melphalan / Q000008:administration & dosage / Q000378:metabolism / Q000493:pharmacokinetics*; D010455:Peptides / Q000493:pharmacokinetics; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D018906:Antineoplastic Agents, Alkylating; D002250:Carbon Radioisotopes; D005971:Glutamates; D010455:Peptides; D008558:Melphalan
Khemobiokinetika sarkolizina i ego peptidnykh analogov s glutaminovoĭ kislotoĭ.