[Laboratory diagnosis of hepatitis C virus infection].
In Austria, the prevalence of hepatitis C virus infections is 0.7% (17). Exclusion of a putative infection as well as diagnosis and continuous monitoring of HCV-disease produce considerable costs for the health system. How many and which patients with HCV infection will acquire life-threatening complications is by far not clear. Also, the causes for viral persistence and liver-complications remain obscure. For certain, complex interactions of viral and immunological mechanisms will determine the individual outcome of the disease (1). These considerations pose decisive demands on clinical diagnostics for HCV infections to be dealt with in detail: methods for qualitative detection of an infection as well as for analysis of subtypes and for quantitative determination of viral copies; monitoring of therapy; estimation of the progress of the disease and/or efficacy of therapy.
Huber
K R
KR
Ludwig Boltzmann-Institut für molekulargenetische Laboratoriumsdiagnostik und Institut für Labormedizin, Langobardenstrasse 122, A-1220 Wien. klaus.huber@smz.magwien.gv.at
Kittl
E
E
Sebesta
C
C
Bauer
K
K
D000998:Antiviral Agents / Q000008:administration & dosage; D005500:Follow-Up Studies; D016174:Hepacivirus / Q000145:classification; D006526:Hepatitis C / Q000150:complications / Q000175:diagnosis* / Q000821:virology; D006801:Humans; D016896:Treatment Outcome; D019562:Viral Load
D000998:Antiviral Agents
Labordiagnostik bei Hepatitis-C-Virus-Infektion.