A comparison of nisoldipine ER and amlodipine for the treatment of mild to moderate hypertension.
This multicentre, double-blind, double-dummy, randomised trial compared the efficacy and tolerability of nisoldipine extended release (10-40 mg) and amlodipine (2.5-10 mg) in 161 patients. The primary end point was a between-treatment comparison of change from baseline to week 8 in mean office diastolic blood pressure (DBP). The least squares mean reductions in systolic (S)BP/DBP (+/- standard error) for nisoldipine and amlodipine were -11.7/-9.3 +/- 1.4/0.8 and -14.3/-12.0 +/- 1.4/0.8 mmHg, respectively. The DBP treatment difference was 2.7 mmHg (90% confidence interval: 1.1 to 4.3 mmHg; p = 0.005). Tolerability profiles were similar between treatments. The drug acquisition cost per mmHg DBP reduction was 40% lower with nisoldipine; an acquisition cost analysis revealed that amlodipine was 80% more expensive than nisoldipine for treating hypertension. In summary, nisoldipine and amlodipine provide clinically equivalent antihypertensive efficacy; however, nisoldipine is more economical than amlodipine.
Whitcomb
C
C
UC Davis Primary Care Network (research for this study was conducted at the University of California Medical School, Sacramento, CA), USA.
Enzmann
G
G
Pershadsingh
H A
HA
Johnson
R
R
Ciuryla
V
V
Reisin
E
E
D000328:Adult; D000368:Aged; D017311:Amlodipine / Q000191:economics / Q000627:therapeutic use*; D000959:Antihypertensive Agents / Q000191:economics / Q000627:therapeutic use*; D001795:Blood Pressure Determination; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D016527:Drug Costs; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000191:economics; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D015737:Nisoldipine / Q000191:economics / Q000627:therapeutic use*; D016037:Single-Blind Method; D013810:Therapeutic Equivalency; D016896:Treatment Outcome
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D017311:Amlodipine; D015737:Nisoldipine