title: A new polymorphism in the promoter region of the human interleukin-16 (IL-16) gene.
abstract: Interleukin 16 (IL-16) is a chemotactic cytokine which binds to CD4 and affects T cell activation. Here we report a novel single nucleotide polymorphism, T to C, in the promoter region of the IL-16 gene in two distinct Asian populations, Japanese and Thai. This mutation occurs at an allele frequency of approximately 22% and 18%, respectively. Although IL-16 potently suppresses replication of human immunodeficiency virus type 1 (HIV-1), we observed no significant difference in the allele frequency of this polymorphism between HIV-1-infected and non-HIV-1-infected individuals in both Asian populations. Since differential IL-16 levels have been reported to be associated with inflammatory diseases such as systemic lupus erythematosus, atopic dermatitis and allergic asthma, it would be of interest to analyze the allele frequency of this mutation in patients with these autoimmune and allergic diseases.
authors.affiliation: Department of Infectious Diseases, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors.forename: E E
authors.initials: EE
authors.lastname: Nakayama
authors.forename: C
authors.initials: C
authors.lastname: Wasi
authors.forename: A
authors.initials: A
authors.lastname: Ajisawa
authors.forename: A
authors.initials: A
authors.lastname: Iwamoto
authors.forename: T
authors.initials: T
authors.lastname: Shioda
mesh_terms: D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics; D006801:Humans; D019410:Interleukin-16 / Q000235:genetics*; D007564:Japan; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D013785:Thailand
chemical_list: D019410:Interleukin-16