title: Production of xanthones with free radical scavenging properties, emodin and sclerotiorin by the cultured lichen mycobionts of Pyrenula japonica.
abstract: From the cultures of the spore-derived mycobionts of the lichen Pyrenula japonica, two new xanthones, 1,8-dihydroxy-3-hydroxymethyl-5-methoxyxanthone and 1,2,8-trihydroxy-5-methoxy-3-methylxanthone, were isolated along with 1,7-dihydroxy-3-methylxanthone, 1,5,8-trihydroxy-3-methylxanthone, 1,8-dihydroxy-5-methoxy-3-methylxanthone, emodin and sclerotiorin. Their structures were determined by spectroscopic methods. Sclerotiorin was isolated for the first time from lichen mycobionts. Radical scavenging activities of the isolated xanthones were also studied.
authors.affiliation: Kobe Pharmaceutical University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takenaka
authors.forename: T
authors.initials: T
authors.lastname: Tanahashi
authors.forename: N
authors.initials: N
authors.lastname: Nagakura
authors.forename: N
authors.initials: N
authors.lastname: Hamada
mesh_terms: D001203:Ascomycota / Q000502:physiology*; D001578:Benzopyrans / Q000737:chemistry / Q000378:metabolism*; D004642:Emodin / Q000737:chemistry / Q000378:metabolism*; D016166:Free Radical Scavengers / Q000737:chemistry*; D007700:Kinetics; D008011:Lichens / Q000502:physiology*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D013172:Spores, Fungal; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000737:chemistry / Q000378:metabolism*
chemical_list: D001578:Benzopyrans; D016166:Free Radical Scavengers; D014966:Xanthenes; C101449:sclerotiorin; D004642:Emodin