[Arterial chemoembolization for metastatic colorectal cancer in the liver].
Transcatheter hepatic artery chemoembolization (THACE) for inoperable colorectal carcinoma metastatic to the liver has been evaluated. Cytostatics were given to 67 patients (Dioxadet 10-30 mg--23; Doxorubicin 40-100 mg--44) in 183 courses using oil and gelatin sponge (1986-1999). Response to treatment (partial decrease in tumor size or growth stabilization) for Dioxadet and Doxorubicin was 47 and 66%, respectively; major complications--17% (fatalities--9%) and 11%, respectively. Mean survival rate was 10 and 11 months; median survival--9 and 10 months, respectively. Repeated THACE-assisted treatment with Doxorubicin was followed by mean survival of 14 months, median--12; one-year survival increased by 77%. THACE-mediated treatment with Dioxadet proved less effective and involved more complications. Further research in modifications of endovascular intervention is needed, including their combinations with systemic treatment of metastatic cancer of the liver.
Tarazov
P G
PG
Central Research Institute of Roentgeno-Radiology, Ministry of Health of the RF, St. Petersburg.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D016461:Chemoembolization, Therapeutic / Q000379:methods*; D015179:Colorectal Neoplasms / Q000473:pathology*; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D016896:Treatment Outcome; D014227:Triazines / Q000008:administration & dosage
D000970:Antineoplastic Agents; D014227:Triazines; D004317:Doxorubicin; C040269:dioxadet
Arterial'naia khimioémbolizatsiia pri metastazakh kolorektal'nogo raka pechen'.