Inhibition of alpha-glucosidase and amylase by luteolin, a flavonoid.
Twenty-one naturally occurring flavonoids were tested for inhibitory activities against alpha-glucosidase (EC 3.2.1.20) and alpha-amylase (EC 3.2.1.1). Luteolin, amentoflavone, luteolin 7-O-glucoside, and daidzein were the strongest inhibitors among the compounds tested. Luteolin inhibited alpha-glucosidase by 36% at the concentration of 0.5 mg/ml and was stronger than acarbose, the most widely prescribed drug, in inhibitory potency, suggesting that it has the possibility to effectively suppress postprandial hyperglycemia in patients with non-insulin dependent diabetes mellitus. Luteolin also inhibited alpha-amylase effectively although it was less potent than acarbose. The clinical value of luteolin needs to be further evaluated.
Kim
J S
JS
Department of Animal Science and Biotechnology, Kyungpook National University, Taegu, Korea. vision@knu.ac.kr
Kwon
C S
CS
Son
K H
KH
D000681:Amylases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D044946:Biflavonoids; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D005960:Glucosides / Q000494:pharmacology; D065089:Glycoside Hydrolase Inhibitors; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy; D007529:Isoflavones / Q000494:pharmacology; D047311:Luteolin; D000520:alpha-Glucosidases / Q000378:metabolism
D044946:Biflavonoids; D004791:Enzyme Inhibitors; D005419:Flavonoids; D005960:Glucosides; D065089:Glycoside Hydrolase Inhibitors; D007529:Isoflavones; C004742:daidzein; C066408:luteolin-7-glucoside; C011164:amentoflavone; D000681:Amylases; D000520:alpha-Glucosidases; D047311:Luteolin