Reevaluation of testicular biopsies of males with nonobstructive azoospermia in assisted reproductive technology.
Spermatogenesis was investigated in seminiferous tubules of 100 males with nonobstructive azoospermia. Forty-four (44%) cases had Sertoli-cell-only syndrome, 23 (23%) had spermatogonium in the tubules, 17 (17%) had primary spermatocyte in the tubules, and 16 (16%) had round or late spermatid in the tubules. No cases showed secondary spermatocyte present in the tubules. The mean serum follicle-stimulating hormone (FSH) in males with nonobstructive azoospermia was significantly higher than that in males with obstructive azoospermia (p < .001). The mean concentrations of serum FSH in cases with Sertoli-cell-only syndrome and spermatogonium in the tubules were significantly higher than those in cases with primary spermatocyte and spermatid in the tubules (p < .05-.001). The results indicate that the evaluation of testicular histology using the type of germ cells present in seminiferous tubules is available for assisted reproductive technology.
Sasagawa
I
I
Department of Urology, Yamagata University, School of Medicine, Japan. isasaga@med.id.yamagata-u.ac.jp
Yazawa
H
H
Suzuki
Y
Y
Tateno
T
T
Ichiyanagi
O
O
Kobayashi
T
T
Matsuki
S
S
Nakada
T
T
D001706:Biopsy; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007621:Karyotyping; D008297:Male; D009845:Oligospermia / Q000473:pathology*; D012099:Reproductive Techniques; D012671:Seminiferous Tubules / Q000473:pathology; D013091:Spermatogenesis; D013737:Testis / Q000473:pathology*
D005640:Follicle Stimulating Hormone