title: Benefits from mianserin augmentation of fluoxetine in patients with major depression non-responders to fluoxetine alone.
abstract: OBJECTIVE
  To assess, in depressed patients, the clinical benefit of mianserin augmentation of fluoxetine or the the benefit of switching treatment from fluoxetine to mianserin.
  
  
  METHODS
  In a 6-week double-blind study we compared the therapeutic efficiency and tolerance of mianserin 60 mg/day (N = 34), mianserin 60 mg/day plus fluoxetine 20 mg/day (N = 32) and continuing fluoxetine 20 mg/day (N = 38) in patients with major depression who did not respond to previous fluoxetine treatment.
  
  
  RESULTS
  Intent-to-treat analysis showed that at week 6 the decrease in the Hamilton Depression rating scale score was significantly (P < or = 0.03) greater in the mianserin plus fluoxetine group when compared to the fluoxetine group (effect size 0.665). Switching from fluoxetine to mianserin gave intermediate results. Mianserin augmentation of fluoxetine was well tolerated.
  
  
  CONCLUSIONS
  Mianserin augmentation of fluoxetine in patients non-responders to fluoxetine 20 mg/day increases response to treatment and is well tolerated.
authors.affiliation: Department of Psychiatry, H pital Saint-Antoine, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: Ferreri
authors.forename: F
authors.initials: F
authors.lastname: Lavergne
authors.forename: I
authors.initials: I
authors.lastname: Berlin
authors.forename: C
authors.initials: C
authors.lastname: Payan
authors.forename: A J
authors.initials: AJ
authors.lastname: Puech
mesh_terms: D000328:Adult; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology / Q000627:therapeutic use*; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D005473:Fluoxetine / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008803:Mianserin / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D018687:Antidepressive Agents, Second-Generation; D005473:Fluoxetine; D008803:Mianserin