[Rhabdomyolysis as a rare complication of theophylline poisoning].
METHODS
A case of a 73-year-old male with theophylline overdose complicated by rhabdomyolysis is reported. After uncontrolled self-medication with an unknown number of theophylline slow release 350 mg tablets and furosemide 40 mg tablets he was admitted with unspecific clinical signs like tachyarrhythmia, vomiting and restlessness. Maximum theophylline concentration was 66.5 mg/l, other abnormal laboratory findings included hypokalemia (2.8 mmol/l) and hyponatremia (123 mmol/l). The maximum creatinkinase level was measured after admission (32.29 mumol/s/l) accompanied by a serum myoglobin level of 3,789 micrograms/l. Immediate treatment with oral activated charcoal and continuous veno-venous hemodialysis (CVVH) was instituted, together with intravenous potassium and sodium chloride substitution, forced diuresis and continuous administration of intravenous metoprolol. The theophylline, creatinkinase and myoglobin levels decreased rapidly and there was no second rise in theophylline found. The patient survived without sequelae.


CONCLUSIONS
Rhabdomyolysis is a rare complication of theophylline intoxication. In literature only a small number of cases are reported. Our results illustrate the necessity of a purposeful and fast management to successfully prevent renal failure or death. Some pathogenetic mechanisms of theophylline-induced rhabdomyolysis, epidemiologic data, risk factors and therapeutical principles will be demonstrated by a detailed literature survey.
Teweleit
S
S
Institut für Klinische Pharmakologie, Friedrich-Schiller-Universität Jena. stefan.teweleit@med uni-jena.de
Hippius
M
M
Pfeifer
R
R
Hoffmann
A
A
D000368:Aged; D003402:Creatine Kinase / Q000097:blood; D003692:Delayed-Action Preparations; D005665:Furosemide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008297:Male; D009211:Myoglobin / Q000097:blood; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D012651:Self Medication; D013806:Theophylline / Q000506:poisoning*
D003692:Delayed-Action Preparations; D009211:Myoglobin; D005665:Furosemide; D013806:Theophylline; D003402:Creatine Kinase
Rhabdomyolyse als seltene Komplikation einer Theophyllinintoxikation.