title: [Long-term action of vitamin D suppresses the estradiol-induced activity of erk-1 MAPK and proliferation of MCF-7 and LNCaP cancer cells].
abstract: A study was made of the influence of a long-term exposure of 1,25-dihydroxyvitamin D3 and 17 beta-estradiol on deactivation of MAP kinases in correlation with proliferation of cancer cells. The obtained results illustrate inhibition of cell growth after vitamin D treatment. Mechanisms of such an inhibition are discussed.
authors.affiliation: Tampere University Medical School, Finland.
authors.forename: A V
authors.initials: AV
authors.lastname: Liakhovich
authors.forename: N L
authors.initials: NL
authors.lastname: Aksenov
authors.forename: P
authors.initials: P
authors.lastname: Tuokhima
authors.forename: V M
authors.initials: VM
authors.lastname: Mikhel'son
mesh_terms: D002117:Calcitriol / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects*; D004790:Enzyme Induction; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists / Q000494:pharmacology*; D006801:Humans; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D014407:Tumor Cells, Cultured
chemical_list: D004965:Estrogen Antagonists; D004958:Estradiol; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases; D002117:Calcitriol
vernacular_title: Dlitel'noe vozdeĭstvie vitamina D podavliaet éstradiolindutsirovannuiu aktivnost' erk-1 MAPKL i proliferatsiiu rakovykh kletok MCF-7 i LNCaP.