Trisomy 11 acute myeloid leukemia: 5 additional cases from the Japan Adult Leukemia Study Group AML-92 and AML-95 databases.
We searched for trisomy 11 in acute myelogenous leukemia (AML) patients using the Japan Adult Leukemia Study Group (JALSG) AML-92 and -95 databases to clarify the clinical and hematologic features of a rare numerical chromosome abnormality. Among the sequentially registered patients of JALSG AML-92 (655 patients) and JALSG AML-95 (531 patients), chromosome findings were obtained for 1074 patients (90.6%); we found 5 patients with trisomy 11 as the sole abnormality. The patients were 4 women and 1 man with trisomy 11 AML, all aged more than 45 years (median, 52 years), with 4 M1 morphologies and 1 M2. No patients manifested hepatosplenomegaly or lymph node enlargement, and no central nervous system leukemia or extramedullary lesions were detectable. All showed positivity for CD13 (5/5), CD33 (5/5), CD34 (3/3), CD38 (2/2), and HLA-DR (5/5). Except for 1 patient, all achieved complete remission after 1 course of induction chemotherapy, but 2 relapsed after discontinuation of chemotherapy. A third case of relapse occurred during intensification of chemotherapy, and the patient underwent allogenic bone marrow transplantation but died from interstitial pneumonia.
Suzuki
A
A
First Department of Internal Medicine, Tokyo Medical University, 6-7-1 Nishi-shinjuku Shinjuku-ku, Tokyo 160-0023, Japan.
Ohyashiki
K
K
Kimura
Y
Y
Yamada
H
H
Sano
F
F
Miyawaki
S
S
Kuriyama
K
K
Ohno
R
R
D000208:Acute Disease; D000368:Aged; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D016208:Databases, Factual; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007564:Japan; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D014314:Trisomy / Q000235:genetics / Q000473:pathology*