3-p-Toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran and 2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran do not act as surfactants or micelles when inhibiting the aggregation of beta-amyloid peptide.
The cmc and IC50 values of the beta-amyloid (Abeta) aggregation inhibitors, 3-p-toluoyl-2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran 1, and 2-[4'-(3-diethylaminopropoxy)-phenyl]-benzofuran 2 have been determined. After comparison of the cmc data and biological data (IC50 values), we conclude that these active benzofurans do not act as surfactants or micelles at the concentration required to inhibit beta-amyloid-peptide aggregation.
Allsop
D
D
Department of Biological Sciences, University of Lancaster, UK.
Gibson
G
G
Martin
I K
IK
Moore
S
S
Turnbull
S
S
Twyman
L J
LJ
D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors* / Q000648:ultrastructure*; D001572:Benzofurans / Q000737:chemistry / Q000494:pharmacology*; D019281:Dimerization; D004305:Dose-Response Relationship, Drug; D004553:Electric Conductivity; D020128:Inhibitory Concentration 50; D008823:Micelles; D019906:Nuclear Magnetic Resonance, Biomolecular; D010456:Peptides, Cyclic; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000494:pharmacology
C425229:2-(4'-(3-diethylaminopropoxy)-phenyl)-benzofuran; C425228:3-p-toluoyl-2-(4'-(3-diethylaminopropoxy)-phenyl)-benzofuran; D016229:Amyloid beta-Peptides; D001572:Benzofurans; D008823:Micelles; D010456:Peptides, Cyclic; D013501:Surface-Active Agents; C425223:pseudomycin B