[Treatment of chronic aplastic anemia with triolandren and cyclosporin A].
OBJECTIVE
To explore more effective regimen for chronic aplastic anemia (CAA).


METHODS
Forty-five cases of CAA were treated with triolandren (TLD) (15 cases) or TLD and cyclosporin A (CsA) (30 cases).


RESULTS
The response rate of TLD-CsA group (83.3%) was higher than that of TLD group (60.0%), furthermore, the recovery of bone marrow colony-forming cell (CFC) number of the responding patients was more complete and rapid in TLD-CsA group than in TLD group. Bone marrow CFC number had no significant change of all nonresponding patients in both groups.


CONCLUSIONS
The response rate of TLD-CsA was higher than that of TLD alone, and the recovery of bone marrow CFC number of the responding patients was more complete and rapid in TLD-CsA group.
Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin, 300020.
Z
Z
Shao
Y
Y
Zheng
Y
Y
Zhang
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000188:drug therapy*; D002455:Cell Division; D002478:Cells, Cultured; D002648:Child; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000473:pathology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013739:Testosterone / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D007166:Immunosuppressive Agents; C009588:triolandren; D013739:Testosterone; D016572:Cyclosporine