Chromosome movement: dynein-out at the kinetochore.
Cell biologists have long speculated that a minus end-directed motor localized at kinetochores contributes to the poleward movement of chromosomes during mitosis. Two recent studies provide direct evidence that cytoplasmic dynein can perform this function.
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3200, USA. jenbanks@uclink4.berkeley.edu
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JD
Banks
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Heald
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D002875:Chromosomes / Q000502:physiology*; D019926:Cyclin B / Q000378:metabolism; D029721:Drosophila Proteins; D000072159:Dynactin Complex; D004398:Dyneins / Q000378:metabolism / Q000502:physiology*; D019476:Insect Proteins / Q000378:metabolism; D016547:Kinesins / Q000378:metabolism; D018386:Kinetochores / Q000378:metabolism / Q000502:physiology*; D008540:Meiosis / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism / Q000502:physiology; D029867:Xenopus Proteins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; C503698:CycB protein, Drosophila; D019926:Cyclin B; D029721:Drosophila Proteins; D000072159:Dynactin Complex; D019476:Insect Proteins; C088335:KIF11 protein, Xenopus; C091489:KIF2C protein, human; D008869:Microtubule-Associated Proteins; D029867:Xenopus Proteins; C068688:centromere protein E; C076055:Zw10 protein, Drosophila; D016203:CDC2 Protein Kinase; D004398:Dyneins; D016547:Kinesins