Transgenic models of ovarian failure.
Reproductive development and function are a complex process requiring the coordinate interactions of multiple extragonadal and intragonadal factors. Peptide hormones from the hypothalamus (eg, gonadotropin releasing hormone) and the pituitary (eg, follicle stimulating hormone, luteinizing hormone, oxytocin) as well as growth factors and steroids from the gonads (eg, inhibins, growth differentiation factor-9, progesterone, estradiol, testosterone) play key functions in regulating specific aspects of reproduction. Our laboratory used spontaneous mutant mice and transgenic mouse models to address the essential roles of some of these factors in the propagation of the mammalian species. This review summarizes some of our initial studies to understand this process.
Yan
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Department of Pathology, Baylor College of Medicine, Houston, Texas 77030, USA.
Matzuk
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D000818:Animals; D055430:Bone Morphogenetic Protein 15; D005260:Female; D055429:Growth Differentiation Factor 9; D006133:Growth Substances / Q000235:genetics / Q000502:physiology; D007265:Inhibins / Q000235:genetics / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D009154:Mutation; D010121:Oxytocin / Q000235:genetics / Q000502:physiology; D016649:Primary Ovarian Insufficiency / Q000235:genetics*; D013482:Superoxide Dismutase / Q000235:genetics / Q000502:physiology
C525902:Bmp15 protein, mouse; D055430:Bone Morphogenetic Protein 15; C525898:Gdf9 protein, mouse; D055429:Growth Differentiation Factor 9; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D010121:Oxytocin; D007265:Inhibins; D013482:Superoxide Dismutase