Differential alterations in plasma colony-stimulating factor concentrations after coronary artery bypass graft surgery with extracorporeal circulation.
To determine whether colony-stimulating factor (CSF) might participate to the inflammatory response after cardiac surgery, plasma concentrations of granulocyte-CSF (G-CSF), macrophage-CSF (M-CSF) and GM-CSF were measured in 31 patients undergoing coronary artery bypass graft (CABG) surgery with extracorporeal circulation (ECC). Plasma G-CSF and M-CSF concentrations increased after weaning of ECC, reached maximum value at the sixth post-operative hour, and remained elevated at the 24th post-operative hour. In contrast, plasma GM-CSF levels did not change. Plasma M-CSF, G-CSF and GM-CSF values were not different whether patients developed post-operative complications or not. In conclusion, M-CSF and G-CSF are produced after CABG surgery despite the use of high aprotinin doses in hope to abrogate the inflammatory response. G-CSF and M-CSF might play a role in the inflammatory process often observed after CABG surgery.
Denizot
Y
Y
EP CNRS 118, Faculté de Médecine, 2 rue Dr. marcland, Limoges, 87025, France. yves.dezinot@unilim.fr
Karoutsos
S
S
Nathan
N
N
D003115:Colony-Stimulating Factors / Q000097:blood*; D001026:Coronary Artery Bypass; D004797:Enzyme-Linked Immunosorbent Assay; D005112:Extracorporeal Circulation; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D007249:Inflammation / Q000097:blood*; D016173:Macrophage Colony-Stimulating Factor / Q000097:blood; D013997:Time Factors
D003115:Colony-Stimulating Factors; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor