Regression of a murine gammaherpesvirus 68-positive b-cell lymphoma mediated by CD4 T lymphocytes.
Murine gammaherpesvirus 68-infected S11 cells were injected subcutaneously into nude mice. Adoptively transferred restimulated lymphocytes consistently elicited the regression of S11 tumors. CD4 T lymphocytes were most effective in preventing tumor formation, and immunohistochemistry highlighted populations of CD4 T cells in regressing tumors.
Department of Veterinary Pathology, University of Edinburgh, Edinburgh EH9 1QH, United Kingdom.
K A
KA
Robertson
E J
EJ
Usherwood
A A
AA
Nash
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000096:biosynthesis; D005260:Female; D018142:Gammaherpesvirinae / Q000302:isolation & purification*; D016219:Immunotherapy, Adoptive; D016393:Lymphoma, B-Cell / Q000628:therapy* / Q000821:virology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude
D016207:Cytokines