[Virus-specific antibodies and interferon therapy in chronic hepatitis C].
OBJECTIVE
To study the spectrum of antibodies in chronic hepatitis C (CHC) against various antigenic structures of hepatitis C virus (HCV) and changes in their quantity in response to interferon treatment.


METHODS
Enzyme immunoassays (kits by Diagnostic Systems, N. Novgorod) were used in examination of 144 CHC patients with circulation of HCV antibodies in peripheral blood.


RESULTS
IgG antibodies to cor, NS3, NS4 HCV antigens were present in the highest percentage (75-100%) and concentration (2.5-1.9 units). IgM antibodies to cor HCV, IgM and IgG to HS5 HCV were detected in 36-63%, concentration of the antibodies ranged 0.7-1.7 units. Interferon therapy reduced frequency and amount of virus-specific antibodies to various antigenic structures of HCV, primarily IgM to cor, NS5-HCV, anti-IgG NS5-HCV.


CONCLUSIONS
In CHC a wide spectrum of antibodies to HCV antigenic structures are produced. They have different biological properties. Interferon treatment diminished their frequency and amount. This allows to consider changes in the amount of virus-specific antibodies in CHC as a criterion of antiviral treatment effectiveness.
Loginov
A S
AS
Tsaregorodtseva
T M
TM
Zotina
M M
MM
Serova
T I
TI
Iakimchuk
G N
GN
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins; D014758:Viral Core Proteins / Q000276:immunology; D017361:Viral Nonstructural Proteins / Q000276:immunology
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007370:Interferon Type I; D011994:Recombinant Proteins; D014758:Viral Core Proteins; D017361:Viral Nonstructural Proteins