Electroconvulsive shock regulates serotonin transporter mRNA expression in rat raphe nucleus.
The antidepressive actions of electroconvulsive shock (ECS) therapy are considered to involve altered neurotransmission of serotonin. In this study, we investigated the effects of acute and chronic ECS on 5-hydroxytryptamine (5-HT) transporter mRNA expression in rat raphe nucleus. We found that serotonin transporter (5-HTT) mRNA expression was decreased in 9 and 24 h after acute ECS and in 3, 9, 24 h and 2 weeks after chronic ECS in rat raphe nucleus. We presume that the adaptive change in 5-HTT mRNA expression is possibly related to the therapeutic efficacy of electroconvulsive therapy (ECT) on medication-resistant depression.
Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan. shenhw@psy.med.tohoku.ac.jp
H
H
Shen
Y
Y
Numachi
S
S
Yoshida
S
S
Toda
S
S
Awata
H
H
Matsuoka
M
M
Sato
D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis*; D004565:Electroconvulsive Therapy; D008297:Male; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger / Q000096:biosynthesis; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D050486:Serotonin Plasma Membrane Transport Proteins; C493232:Slc6a4 protein, rat