A physical map of the human genome.
The human genome is by far the largest genome to be sequenced, and its size and complexity present many challenges for sequence assembly. The International Human Genome Sequencing Consortium constructed a map of the whole genome to enable the selection of clones for sequencing and for the accurate assembly of the genome sequence. Here we report the construction of the whole-genome bacterial artificial chromosome (BAC) map and its integration with previous landmark maps and information from mapping efforts focused on specific chromosomal regions. We also describe the integration of sequence data with the map.
Washington University School of Medicine, Genome Sequencing Center, Department of Genetics, St. Louis, Missouri 63108, USA. jmcphers@watson.wustl.edu
J D
JD
McPherson
M
M
Marra
L
L
Hillier
R H
RH
Waterston
A
A
Chinwalla
J
J
Wallis
M
M
Sekhon
K
K
Wylie
E R
ER
Mardis
R K
RK
Wilson
R
R
Fulton
T A
TA
Kucaba
C
C
Wagner-McPherson
W B
WB
Barbazuk
S G
SG
Gregory
S J
SJ
Humphray
L
L
French
R S
RS
Evans
G
G
Bethel
A
A
Whittaker
J L
JL
Holden
O T
OT
McCann
A
A
Dunham
C
C
Soderlund
C E
CE
Scott
D R
DR
Bentley
G
G
Schuler
H C
HC
Chen
W
W
Jang
E D
ED
Green
J R
JR
Idol
V V
VV
Maduro
K T
KT
Montgomery
E
E
Lee
A
A
Miller
S
S
Emerling
Kucherlapati
R
R
Gibbs
S
S
Scherer
J H
JH
Gorrell
E
E
Sodergren
K
K
Clerc-Blankenburg
P
P
Tabor
S
S
Naylor
D
D
Garcia
P J
PJ
de Jong
J J
JJ
Catanese
N
N
Nowak
K
K
Osoegawa
S
S
Qin
L
L
Rowen
A
A
Madan
M
M
Dors
L
L
Hood
B
B
Trask
C
C
Friedman
H
H
Massa
V G
VG
Cheung
I R
IR
Kirsch
T
T
Reid
R
R
Yonescu
J
J
Weissenbach
T
T
Bruls
R
R
Heilig
E
E
Branscomb
A
A
Olsen
N
N
Doggett
J F
JF
Cheng
T
T
Hawkins
R M
RM
Myers
J
J
Shang
L
L
Ramirez
J
J
Schmutz
O
O
Velasquez
K
K
Dixon
N E
NE
Stone
D R
DR
Cox
D
D
Haussler
W J
WJ
Kent
T
T
Furey
S
S
Rogic
S
S
Kennedy
S
S
Jones
A
A
Rosenthal
G
G
Wen
M
M
Schilhabel
G
G
Gloeckner
G
G
Nyakatura
R
R
Siebert
B
B
Schlegelberger
J
J
Korenberg
X N
XN
Chen
A
A
Fujiyama
M
M
Hattori
A
A
Toyoda
T
T
Yada
H S
HS
Park
Y
Y
Sakaki
N
N
Shimizu
S
S
Asakawa
K
K
Kawasaki
T
T
Sasaki
A
A
Shintani
A
A
Shimizu
K
K
Shibuya
J
J
Kudoh
S
S
Minoshima
J
J
Ramser
P
P
Seranski
C
C
Hoff
A
A
Poustka
R
R
Reinhardt
H
H
Lehrach
D022202:Chromosomes, Artificial, Bacterial; D003001:Cloning, Molecular; D020451:Contig Mapping; D016172:DNA Fingerprinting; D020440:Gene Duplication; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D012091:Repetitive Sequences, Nucleic Acid