Immunoblotting detection of gamma-catenin (plakoglobin) antibody in the serum of a patient with paraneoplastic pemphigus.
We report a patient with paraneoplastic pemphigus associated with a thymic tumour. Immunoblot study using affinity-purified gamma-catenin protein revealed that his serum recognized gamma-catenin (plakoglobin) in epidermal, thymic tumour and mouse bladder extracts.
Department of Dermatology, Niigata University School of Medicine, Asahimachi-dori 1, Niigata 951-8510, Japan.
M
M
Ishii
J
J
Izumi
H
H
Fujiwara
M
M
Ito
M
M
Hamada
D001323:Autoantibodies / Q000097:blood*; D003598:Cytoskeletal Proteins / Q000276:immunology*; D051180:Desmoplakins; D003896:Desmosomes / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology / Q000276:immunology*; D010392:Pemphigus / Q000209:etiology / Q000276:immunology*; D013953:Thymus Neoplasms / Q000150:complications; D051185:gamma Catenin
D001323:Autoantibodies; D003598:Cytoskeletal Proteins; D051180:Desmoplakins; C495292:JUP protein, human; D051185:gamma Catenin