Variations in plasma soluble tumour necrosis factor receptors after diet-induced weight loss in obesity.
The aim of this study was to investigate the variations in the plasma levels of the soluble tumour necrosis factor receptor type-I (sTNFR-I) and type-II (sTNFR-II) during weight loss which was induced by 3 weeks on a very low calorie diet (3.9+/-0.1 MJ/day), in 17 non-diabetic obese women. Plasma sTNFR-I concentrations decreased significantly after weight loss (p < 0.05), but there was no significant change in plasma sTNFR-II. As the diet was associated with a significant decrease in body fat mass (=2.5 kg), this result supports the emerging concept that adipose tissue can produce significant amounts of sTNFR-I and that this production can be modified by weight loss in human obesity.
Service de Biochimie, H pital de la Salpêtrière, Paris, France. jean-philippe.bastard@tnn.ap-hop-paris.fr
J P
JP
Bastard
C
C
Jardel
E
E
Bruckert
H
H
Vidal
B
B
Hainque
D015703:Antigens, CD / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000503:physiopathology; D018124:Receptors, Tumor Necrosis Factor / Q000097:blood*; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D015431:Weight Loss / Q000502:physiology*; D044465:White People
D015703:Antigens, CD; D001786:Blood Glucose; D007328:Insulin; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II