Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice.
The acute and accumulated toxicity of the rare earth borotungstate heteropoly blues, HPB-2, Ce2H3[BW9(VI)W2(V)Mn(H2O)O39].12H2O, which is active against influenza virus in Kunming mice, were investigated in Kunming mice following oral and intraperitoneal administration. The activity of HPB-2 against influenza virus (FM1) in the mice was then investigated. HPB-2, given either orally (p.o.) or intraperitoneally (i.p.), was shown to have activity. HPB-2 was shown to be more effective than the positive control, ribavirin, and it was also found that i.p. administration was more effective than p.o. administration.
Liu
J
J
State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry, Zhongshan University, Guangzhou, PR China. cesliuj@zsu.edu.cn
Mei
W
W
Li
Y
Y
Wang
E
E
Ji
L
L
Tao
P
P
D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D001896:Boron Compounds / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D017973:Tungsten Compounds / Q000008:administration & dosage*
D000998:Antiviral Agents; D001896:Boron Compounds; D017973:Tungsten Compounds; C067364:borotungstic acid