[Detection of interleukin-8 level in peripheral blood of patients with aplastic anemia].
OBJECTIVE
To investigate the role of interleukin-8 in the pathogenesis of aplastic anemia (AA) and its correlation with clinical status.


METHODS
Serum level of IL-8 in 24 AA patients and 20 normal controls was measured by sandwich enzyme linked immunosorbent assay(ELISA).


RESULTS
The levels of IL-8 were increased significantly(P < 0.05) in AA patients than in normal controls, and the IL-8 levels in severe AA group were much higher than those in chronic AA group (P < 0.05). Serum IL-8 in AA patients with infection were elevated significantly(P < 0.005).


CONCLUSIONS
IL-8 may have a potential role in the pathogenesis of AA and determination of serum IL-8 may be helpful for evaluation of severity and infectious complication of AA.
Department of Hematology, First Affiliated Hospital, Suzhou Medical College, Suzhou 215006.
X
X
Tang
Y
Y
Zhang
J
J
Shao
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000097:blood*; D002648:Child; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000097:blood*; D008297:Male; D008875:Middle Aged
D016209:Interleukin-8