An immune algorithm for resolution of multicomponent overlapping chromatograms.
A novel immune algorithm for resolution and quantitative determination of the components in overlapping chromatograms was proposed by imitating biological immune systems. The algorithm takes an overlapping chromatogram as its input and subtracts the chromatograms of standard samples from the input by iteration of a network. When the residual does not change, the network will converge and chromatographic information of the components in overlapping chromatogram will be obtained. Both simulated and experimental data sets were investigated by the method. Results showed that both resolved results and recoveries of quantitative determination are satisfactory. Comparing with conventional least-square method, the immune algorithm is fast in calculation.
Shao
X
X
Department of Chemistry, University of Science and Technology of China, Hefei, P.R. China. xshao@ustc.edu.cn
Chen
Z
Z
Lin
X
X
D000465:Algorithms; D001554:Benzene / Q000737:chemistry; D002845:Chromatography; D003198:Computer Simulation; D000939:Epitopes / Q000737:chemistry; D007107:Immune System / Q000502:physiology*; D007074:Immunoglobulin G / Q000737:chemistry; D016018:Least-Squares Analysis; D008432:Mathematical Computing
D000939:Epitopes; D007074:Immunoglobulin G; D001554:Benzene