A new member of the spalt like zinc finger protein family, Msal-3, is expressed in the CNS and sites of epithelial/mesenchymal interaction.
We have identified a new member of the spalt-like gene family in mice, msal-3. We compared the expression patterns of msal-3 and msal-1 during development and show that they exhibit overlapping yet exclusive patterns of expression in the developing forebrain, diencephalon, midbrain/hindbrain boundary and spinal cord. Both genes are expressed from E7 in opposite gradients in primitive streak mesoderm. Subsequently their transcripts are localized to regions of mesenchyme/epithelial interaction in the palate, heart, limbs, anal and urogenital region.
Ott
T
T
Department of Molecularbiology, Institute of Genetics, Roemerstrasse 164, 53117, Bonn, Germany.
Parrish
M
M
Bond
K
K
Schwaeger-Nickolenko
A
A
Monaghan
A P
AP
D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis*; D002490:Central Nervous System / Q000196:embryology*; D004268:DNA-Binding Proteins; D004027:Diencephalon / Q000196:embryology; D004622:Embryo, Mammalian / Q000378:metabolism; D004848:Epithelium / Q000196:embryology*; D018398:Homeodomain Proteins / Q000096:biosynthesis*; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000196:embryology; D008648:Mesoderm / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009474:Neurons / Q000378:metabolism; D009830:Olfactory Bulb / Q000196:embryology; D016548:Prosencephalon / Q000196:embryology; D012249:Rhombencephalon / Q000196:embryology; D013116:Spinal Cord / Q000196:embryology; D013997:Time Factors; D014018:Tissue Distribution; D014157:Transcription Factors / Q000096:biosynthesis; D029867:Xenopus Proteins; D016335:Zinc Fingers
D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; C491254:Sall1 protein, mouse; C484467:Sall3 protein, mouse; D014157:Transcription Factors; D029867:Xenopus Proteins; C103405:sal1-A protein, Xenopus; C484468:spalt protein, vertebrate