How cells read TGF-beta signals.
Cell proliferation, differentiation and death are controlled by a multitude of cell-cell signals, and loss of this control has devastating consequences. Prominent among these regulatory signals is the transforming growth factor-beta (TGF-beta) family of cytokines, which can trigger a bewildering diversity of responses, depending on the genetic makeup and environment of the target cell. What are the networks of cell-specific molecules that mould the TGF-beta response to each cell's needs?
Cell Biology Program and Howard Hughes Medical Institute, Memorial Sloan-Kettering Cancer Center, Box 116, 1275 York Avenue, New York, New York 10021, USA. j-massague@ski.mskcc.org
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D000818:Animals; D002455:Cell Division; D006801:Humans; D020935:MAP Kinase Signaling System; D008954:Models, Biological; D018125:Receptors, Transforming Growth Factor beta / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000737:chemistry / Q000502:physiology*
D018125:Receptors, Transforming Growth Factor beta; D016212:Transforming Growth Factor beta