Expressing the human genome.
We have searched the human genome for genes encoding new proteins that may be involved in three nuclear gene expression processes: transcription, pre-messenger RNA splicing and polyadenylation. A plethora of potential new factors are implicated by sequence in nuclear gene expression, revealing a substantial but selective increase in complexity compared with Drosophila melanogaster and Caenorhabditis elegans. Although the raw genomic information has limitations, its availability offers new experimental approaches for studying gene expression.
Tupler
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R
Howard Hughes Medical Institute, University of Massachusetts Medical School, Worcester 01605, USA.
Perini
G
G
Green
M R
MR
D000818:Animals; D015870:Gene Expression; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D011061:Poly A / Q000378:metabolism; D012326:RNA Splicing; D014157:Transcription Factors / Q000235:genetics; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D014157:Transcription Factors; D011061:Poly A