Nucleosomal positioning and genetic divergence study based on DNA flexibility map.
Based on worm like chain model, DNA structural parameters--tilt, roll and rise, derived from crystallographic database have been used to determine the flexibility of DNA that regulates the nucleosomal translational positioning. Theoretically derived data has been compared to the experimental values available in loshikhes and Trifonov's database. The methodology has been extended to determine the flexibility of 18S rRNA genome in eukarya, where yeast shows a distinct difference when compared with mammals like human, mouse and rabbit.
Kundu
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S
Department of Biophysics, Molecular Biology & Genetics, University College of Science, Calcutta, India.
Bhattacharya
D
D
Thakur
A R
AR
Majumdar
R
R
D000818:Animals; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D016208:Databases, Factual; D005057:Eukaryotic Cells; D014644:Genetic Variation; D016678:Genome; D006801:Humans; D051379:Mice; D009707:Nucleosomes / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D010802:Phylogeny; D014176:Protein Biosynthesis; D012337:RNA, Ribosomal, 18S / Q000737:chemistry*; D011817:Rabbits; D051381:Rats
D009707:Nucleosomes; D012337:RNA, Ribosomal, 18S; D004247:DNA