[Signal changes of the bone marrow in MRI under long-term treatment with granulocyte colony-stimulating factors].
OBJECTIVE
Recurrent infections in patients with glycogen storage disease (GSD) type Ib resulting from an associated neutropenia are frequently treated with granulocyte colony-stimulating factors (G-CSF). The aim of this study was to evaluate the changes occurring in bone marrow by magnetic resonance imaging (MRI) in these patients.


METHODS
The distal femoral and tibial bones of six patients with GSD Ib were evaluated by MRI. Four of these patients were treated with G-CSF for at least 3.9 to a maximum of 8.2 years (mean 5.8 years). The imaging sequences encompassed spin-echo as well as short-time inversion recovery sequences. 4 of the 6 patients had bone marrow aspirations.


RESULTS
The patients who had undergone therapy with G-CSF showed a marked increase in signal strength in STIR sequences which encompassed the entire medullar cavity. In T1-weighted images these areas were hypointense. Biopsies obtained from these patients showed a bone marrow hypercellularity. The patients without G-CSF therapy showed the same signal intensity changes but with a more discrete and localized pattern in the metaphyseal cavities.


CONCLUSIONS
In subjects with GSD Ib, an increased myelopoetic activity of the bone marrow which is intensified under long-term treatment with G-CSF can be demonstrated by MRI.
Scherer
A
A
Institut für Diagnostische Radiologie, Heinrich-Heine-Universität Düsseldorf. scherera@uni-duesseldorf.de
Engelbrecht
V
V
May
P
P
Neises
G
G
Wendel
U
U
Mödder
U
U
D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D005260:Female; D005269:Femur; D005953:Glycogen Storage Disease Type I / Q000188:drug therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D011994:Recombinant Proteins; D013977:Tibia; D013997:Time Factors
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor