Transdominant genetics, peptide inhibitors and drug targets.
The future of medical therapy is tied to the discovery of high-quality drug targets and drugs. Transdominant genetics provides a function-based route to peptide inhibitors that can be used as probes to identify protein targets or as reagents for drug development. Both forward-genetic and reverse-genetic applications have been implemented. The move is now underway to expand upon advances made in model systems and exploit screens of real therapeutic value.
Kamb
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Arcaris Inc, 615 Arapeen Dr, Suite 300, Salt Lake City, UT 84108, USA. kamb@arcaris.com
Teng
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D000818:Animals; D015195:Drug Design; D005799:Genes, Dominant / Q000187:drug effects; D005821:Genetic Techniques; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D010641:Phenotype; D011506:Proteins / Q000037:antagonists & inhibitors / Q000235:genetics
D010455:Peptides; D011506:Proteins