Saponins from the roots of Zygophyllum gaetulum and their effects on electrically-stimulated guinea-pig ileum.
A new ursanolide, 3beta-O-alpha-L-rhamnopyranosyl-(1->2)-O-alpha-L-arabinopyranosyl-(1->2)-beta-D-glucopyranosyl)oxy]-ursan-20beta,28-olide, zygophyloside N (1), and three known quinovic acid glycosides were isolated from the methanolic extract of the roots of Zygophyllum gaetulum. The crude extract, some fractions and 3-O-beta-D-glucopyranosyl quinovic acid 28-beta-D-glucopyranosyl ester, significantly and dose-dependently, are able to reduce the electrically-induced contractions of isolated guinea-pig ileum. The structure of compound (1) was determined, using 1D and 2D NMR techniques.
Dipartimento di Scienze Farmaceutiche, Università di Salerno, Fisciano, Salerno, Italy.
R
R
Aquino
S
S
Tortora
S
S
Fkih-Tetouani
A
A
Capasso
D000818:Animals; D002240:Carbohydrate Sequence; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008969:Molecular Sequence Data; D009018:Morocco; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010276:Parasympatholytics / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014315:Triterpenes
C434365:3-O-rhamnopyranosyl-(1-2)-O-arabinopyranosyl-(1-2)-glucopyranosyl-oxy-ursan-20,28-olide; D010276:Parasympatholytics; D012503:Saponins; D014315:Triterpenes