Protective effect of recombinant human augmenter of liver regeneration on CCl4-induced hepatitis in mice.
OBJECTIVE
To observe the anti-injury role of recombinant human augmenter of liver regeneration.


METHODS
To establish liver injury models induced by CCl4 in vivo and in vitro, cell survival rates and LDH release rates served as observing index in experiments in vitro. Survival rates of liver failure animals, serum concentration of ALT, LDH, DNA and pathological examination were selected as parameters in experiment in vivo.


RESULTS
rhALR could increase the survival rates and decrease the LDH release rates of injured hepatocytes in vitro. rhALR could also increase the survival rates of liver failure animal, promote hepatocyte proliferation and decrease the serum level of ALT and LDH in vivo.


CONCLUSIONS
ALR is an important stimulator for liver regeneration and may play important role in liver damage repair.
Beijing Institute of Radiation Medicine, Beijing 100850, China.
X
X
Yang
A
A
Wang
P
P
Zhou
Q
Q
Wang
H
H
Wei
Z
Z
Wu
F
F
He
D000818:Animals; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000628:therapy*; D004247:DNA / Q000096:biosynthesis; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008099:Liver / Q000166:cytology; D008115:Liver Regeneration / Q000187:drug effects*; D008297:Male; D051379:Mice; D011506:Proteins; D011994:Recombinant Proteins / Q000494:pharmacology; D050862:Oxidoreductases Acting on Sulfur Group Donors
D004247:DNA; D006133:Growth Substances; D007770:L-Lactate Dehydrogenase; D011506:Proteins; D011994:Recombinant Proteins; C088825:GFER protein, rat; D050862:Oxidoreductases Acting on Sulfur Group Donors