Medullary serotonergic network deficiency in the sudden infant death syndrome: review of a 15-year study of a single dataset.
The sudden infant death syndrome (SIDS) is the leading cause of postneonatal infant mortality in the United States today, despite a dramatic 38% decrease in incidence due to a national risk reduction campaign advocating the supine sleep position. Our research in SIDS brainstems, beginning in 1985 and involving a single, large dataset, has become increasingly focused upon a specific neurotransmitter (serotonin) and specific territories (ventral medulla and regions of the medullary reticular formation that contain secrotonergic neurons). Based on this research, we propose that SIDS, or a subset of SIDS, is due to a developmental abnormality in a medullary network composed of (at least in part) rhombic lip-derived, serotonergic neurons, including in the caudal raphé and arcuate nucleus (putative human homologue of the cat respiratory chemosensitive fields); and this abnormality results in a failure of protective responses to life-threatening stressors (e.g. asphyxia, hypoxia, hypercapnia) during sleep as the infant passes through a critical period in homeostatic control. We call this the medullary serotonergic network deficiency hypothesis. We review the triple-risk model for SIDS, the development of the dataset using tissue autoradiography for analyzing neurotransmitter receptor binding; age-dependent baseline neurochemical findings in the human brainstem during early life; the evidence for serotonergic, rhombic lip, and ventral medullary deficits in at least some SIDS victim; possible mechanisms of sudden infant death related to these deficits; and potential causes of the deficits in the medullary serotonergic network in SIDS victims. We conclude with a summary of future directions in SIDS brainstem research.
Kinney
H C
HC
Department of Pathology, Children's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.
Filiano
J J
JJ
White
W F
WF
D000818:Animals; D006801:Humans; D007223:Infant; D008526:Medulla Oblongata / Q000378:metabolism* / Q000473:pathology*; D009415:Nerve Net / Q000378:metabolism*; D012701:Serotonin / Q000172:deficiency*; D013398:Sudden Infant Death / Q000473:pathology*
D012701:Serotonin