Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
Luo
Y
Y
Amgen, One Amgen Center Drive, MS 29-2-B, Thousand Oaks, California 91320, USA.
Bolon
B
B
Kahn
S
S
Bennett
B D
BD
Babu-Khan
S
S
Denis
P
P
Fan
W
W
Kha
H
H
Zhang
J
J
Gong
Y
Y
Martin
L
L
Louis
J C
JC
Yan
Q
Q
Richards
W G
WG
Citron
M
M
Vassar
R
R
D000544:Alzheimer Disease / Q000201:enzymology* / Q000378:metabolism*; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000172:deficiency* / Q000235:genetics; D002490:Central Nervous System / Q000201:enzymology; D010450:Endopeptidases; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics / Q000378:metabolism; D017933:Peripheral Nervous System / Q000201:enzymology; D010641:Phenotype; D058225:Plaque, Amyloid / Q000201:enzymology
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse