Membrane-anchored peptide inhibits human immunodeficiency virus entry.
Peptides derived from the heptad repeats of human immunodeficiency virus (HIV) gp41 envelope glycoprotein, such as T20, can efficiently inhibit HIV type 1 (HIV-1) entry. In this study, replication of HIV-1 was inhibited more than 100-fold in a T-helper cell line transduced with a retrovirus vector expressing membrane-anchored T20 on the cell surface. Inhibition was independent of coreceptor usage.
Heinrich-Pette-Institut für Experimentelle Virologie und Immunologie an der Universität Hamburg, Germany.
M
M
Hildinger
M T
MT
Dittmar
P
P
Schult-Dietrich
B
B
Fehse
B S
BS
Schnierle
S
S
Thaler
G
G
Stiegler
R
R
Welker
D
D
von Laer
D000595:Amino Acid Sequence; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism; D000077560:Enfuvirtide; D005822:Genetic Vectors; D015700:HIV Envelope Protein gp41 / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D012190:Retroviridae / Q000235:genetics; D006377:T-Lymphocytes, Helper-Inducer / Q000821:virology*; D014161:Transduction, Genetic; D014779:Virus Replication
D015700:HIV Envelope Protein gp41; D010446:Peptide Fragments; D000077560:Enfuvirtide