Umbilical cord blood for allogeneic transplantation in children and adults.
Early clinical reports outlining outcomes for primarily pediatric patients undergoing UCB transplantation, point to delayed time to hematopoietic recovery, and favorable incidence and severity of graft-versus-host disease. Intensive clinical and laboratory research is ongoing focused on strategies to foster UCB allogeneic donor engraftment, thereby allowing wider application of this stem cell source for patients requiring allogeneic transplantation.
Laughlin
M J
MJ
Department of Medicine, Case Western Reserve University, University Hospitals Ireland Cancer Center, Cleveland, Ohio, USA.
D000328:Adult; D001771:Blood Banks; D001803:Blood Transfusion; D017690:Cell Transplantation / Q000009:adverse effects / Q000379:methods / Q000592:standards; D002648:Child; D005312:Fetal Blood / Q000166:cytology; D006086:Graft vs Host Disease / Q000453:epidemiology / Q000209:etiology; D006801:Humans; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000379:methods / Q000592:standards