Homeostasis of alpha beta TCR+ T cells.
Cytokines contribute to T cell homeostasis at all stages of T cell existence. However, the particular cytokine involved varies as T cells progress from a naïve through an activated to a memory state. In many cases the important cytokines are members of the interleukin 2 subfamily of the short-chain type I cytokines. A case is made for the idea that the evolutionary divergence of the short-chain family allowed for concurrent divergence in leukocytes.
Howard Hughes Medical Institute, University of Colorado Health Sciences Center, Denver, CO 80206, USA. marrackp@nuc.org
P
P
Marrack
J
J
Bender
D
D
Hildeman
M
M
Jordan
T
T
Mitchell
M
M
Murakami
A
A
Sakamoto
B C
BC
Schaefer
B
B
Swanson
J
J
Kappler
D000818:Animals; D016207:Cytokines / Q000276:immunology / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology / Q000378:metabolism; D008213:Lymphocyte Activation / Q000276:immunology; D018655:Lymphocyte Count; D016693:Receptors, Antigen, T-Cell, alpha-beta; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology
D016207:Cytokines; D007376:Interleukin-2; D016693:Receptors, Antigen, T-Cell, alpha-beta