Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia.
Macrophages can account for up to 50% of tumour mass and secrete many angiogenic factors. Furthermore, tumour hypoxia is thought to play a major role in the activation of macrophages and the regulation of angiogenesis. In this paper, we demonstrate a strong correlation between hypoxia and the recruitment of immune cells binding to IgG in 8 experimental tumours. We provide evidence that IgG binding immune cells in 3 tumour lines are predominately composed of macrophages. Reduced oxygenation may act as a stimulus for recruitment of immune cells to the tumour mass, and the detection of either IgG-positive host cells or macrophages may offer an alternative method for monitoring tumour hypoxia.
Collingridge
D R
DR
PET Oncology Group, Imperial College School of Medicine, Hammersmith Hospital, MRC Cyclotron Building, Du Cane Road, London, W12 0NN, UK.
Hill
S A
SA
Chaplin
D J
DJ
D000818:Animals; D015687:Cell Hypoxia; D005260:Female; D005434:Flow Cytometry; D005544:Forecasting; D007074:Immunoglobulin G / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000276:immunology*; D014407:Tumor Cells, Cultured
D007074:Immunoglobulin G