Drug-induced liver disease.
Drug-induced liver disease may account for between 10% and 50% of adult patients with elevated enzymes, especially in patients over age 50 years. It accounts for nearly 25% of patients with fulminant hepatic failure. Liver injury can be cytotoxic, cholestatic, or mixed. A variety of systemic manifestations can accompany drug-induced hepatotoxicity. Drug-induced liver disease can mimic autoimmune hepatitis or it can evolve to cirrhosis. It can also mimic veno-occulusive disorders. The plethora of herbal and traditional agents currently ingested by many people should always be considered in any patient with abnormal hepatic biochemistry.
Armed Forces Institute of Pathology, Washington, DC, USA.
H J
HJ
Zimmerman
D056486:Chemical and Drug Induced Liver Injury; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D015994:Incidence; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000453:epidemiology / Q000503:physiopathology; D008107:Liver Diseases / Q000453:epidemiology / Q000503:physiopathology*; D008297:Male; D011379:Prognosis; D018570:Risk Assessment; D012720:Severity of Illness Index