[Tissue-specific splicing of 5'-exons of the Oct-1 transcription factor gene].
It has been shown that pro-mRNA of transcription factor Oct-1 undergoes the tissue-specific splicing. The Oct-1L subform is synthesized in mouse lymphoid myeloma cells NS/0 of the B series and is not found in other somatic and embryonal cells. Initiation sites of oct-1R mRNA transcription are at positions -159 and -307 from the AUG codon of the oct-1R exon. In both cases, no TATA box was found in the region preceding these sites (25-30 bp). A different form of oct-1 mRNA (oct-1U) was also found in NS/0 cells, which is probably synthesized in all cell lines. This subform differs from oct-1R, in particular, by the structure of the 5T-terminal exon, which is the result of alternative splicing.
Pankratova
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004247:DNA; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D005091:Exons; D051863:Host Cell Factor C1; D051379:Mice; D008969:Molecular Sequence Data; D050811:Octamer Transcription Factor-1; D016133:Polymerase Chain Reaction; D012322:RNA Precursors / Q000235:genetics; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*; D014407:Tumor Cells, Cultured
D004268:DNA-Binding Proteins; C497693:Hcfc1 protein, mouse; D051863:Host Cell Factor C1; D050811:Octamer Transcription Factor-1; C494166:Pou2f1 protein, mouse; D012322:RNA Precursors; D012333:RNA, Messenger; D014157:Transcription Factors; D004247:DNA