Gliomagenesis: genetic alterations and mouse models.
Glioblastoma multiforme is the most malignant of the primary brain tumours and is almost always fatal. The treatment strategies for this disease have not changed appreciably for many years and most are based on a limited understanding of the biology of the disease. However, in the past decade, characteristic genetic alterations have been identified in gliomas that might underlie the initiation or progression of the disease. Recent modelling experiments in mice are helping to delineate the molecular aetiology of this disease and are providing systems to identify and test novel and rational therapeutic strategies.
Departments of Neurosurgery, Neurology and Cell Biology, Memorial Sloan Kettering Cancer Center, 1,275 York Avenue, New York, New York 10021, USA. hollande@mskcc.org
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D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002453:Cell Cycle; D004195:Disease Models, Animal; D005910:Glioma / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D006133:Growth Substances / Q000378:metabolism; D051379:Mice; D015398:Signal Transduction
D006133:Growth Substances