The stability of 6-mercaptopurine riboside in neutral and basic medium.
The kinetics of hydrolysis of 6-mercaptopurine riboside (R-6-MP) was studied in aqueous solutions over the pH range of 6.11-12.13 at 353 K. The decomposition was investigated by HPLC method. At the pH range from 6.11 to 12.13 hydrolysis of 6-mercaptopurine riboside includes: spontaeous hydrolysis of non-protonated R-6-MP molecules mono- and di-anions R-6-MP molecules under the effect of water.
Jelińska
A
A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Magdziarz
M
M
D000964:Antimetabolites, Antineoplastic / Q000737:chemistry*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007700:Kinetics; D013868:Thioinosine / Q000737:chemistry*
D000964:Antimetabolites, Antineoplastic; D013868:Thioinosine