Lipoprotein lipase: physiology, biochemistry, and molecular biology.
Lipoprotein lipase (LpL) is the primary enzyme responsible for conversion of lipoprotein triglyceride into free fatty acids and monoglyderides. This permits their uptake into muscle and adipose. The roles of this enzyme in normal and altered physiology are reviewed. In addition, the relationship of LpL activity and genetic variations of LpL and human disease are summarized.
Goldberg
I J
IJ
Division of Preventive Medicine and Nutrition, Columbia University College of Physicians and Surgeons, 630 W. 168th St., New York, NY 10032, USA. ijg3@columbia.edu
Merkel
M
M
D000818:Animals; D001161:Arteriosclerosis / Q000235:genetics; D006801:Humans; D008071:Lipoprotein Lipase / Q000235:genetics / Q000378:metabolism*; D008074:Lipoproteins / Q000378:metabolism; D009154:Mutation; D014280:Triglycerides / Q000378:metabolism
D008074:Lipoproteins; D014280:Triglycerides; D008071:Lipoprotein Lipase