Serum cholesteryl ester transfer protein concentrations in healthy Chinese subjects and cardio-cerebrovascular disease patients.
Serum cholesteryl ester transfer protein (CETP) concentration was measured in 1128 healthy Chinese subjects using a "sandwich" enzyme immunoassay and was 1.84 +/- 1.55 mg/l (mean +/- S.D.). The frequency distribution of CETP in healthy subjects was markedly skewed towards low concentrations. The CETP concentration in females was significantly higher than that in males (2.40 +/- 1.65 mg/l vs. 1.49 +/- 1.37 mg/l, P < 0.001). There was a weak inverse correlation between the CETP concentration and age (r = -0.19, P < 0.001). The CETP concentrations were significantly higher in 117 myocardial infarction (MI) survivors and 110 stroke patients than that in 335 healthy, age-matched males (1.98 +/- 1.68 173 +/- 1.45, and 1.40 +/- 1.37 mg/l respectively, P < 0.01), while no relation was found between CETP concentration and lipids concentration in MI, stroke and healthy group.
Biochemistry Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, 305 East Zhongshan Road, 210002, Nanjing, PR China.YYZhuang@public1.ptt.is.cn
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Zhuang
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Wang
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Qiang
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Li
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Lui
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Li
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Chen
D002318:Cardiovascular Diseases / Q000097:blood* / Q000208:ethnology; D002352:Carrier Proteins / Q000097:blood*; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000208:ethnology; D002681:China; D053480:Cholesterol Ester Transfer Proteins; D005260:Female; D006023:Glycoproteins; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008055:Lipids