[Determination of liquid-crystalline transition temperature of temperature-sensitive liposomes of futraful by 1HNMR].
1HNMR was employed to determine the liquid-crystalline transition temperature (TC) of the temperature-sensitive liposomes of futraful. It is a method with high sensitivity, high accuracy and furnishing more information. The 1HNMR spectra were made and studied. The rate of peak height increase of phospholipid correlates to the thermotropic phase transition of liposomes. The study shows that the TC of DPPC-liposomes and DSPC-liposomes is 36 degrees C and 48 degrees C, respectively. The TC of DPPC-DSPC-liposomes correlates with the proportion of the amount of DPPC and DSPC. The TC is not affected by futraful. The temperature-sensitive liposomes of futraful with TC of 41 degrees C were prepared which consisted of 60% DPPC and 40% DSPC.
Department of Pharmacology, College of Pharmacy of the Second Military Medical University, Shanghai 200433.
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Zhang
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Jiang
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Yang
D003459:Crystallins / Q000032:analysis; D008081:Liposomes; D008279:Magnetic Resonance Imaging; D005641:Tegafur / Q000737:chemistry*; D013696:Temperature
D003459:Crystallins; D008081:Liposomes; D005641:Tegafur