Chemokines in lymphopoiesis and lymphoid organ development.
An important role has emerged for chemokines in regulating the distribution of progenitor cells during hematopoietic cell development. As well as recruiting cells, chemokines promote cell retention and cytokine expression. Furthermore, chemokines have been found to have an inductive function in secondary lymphoid organ development.
Howard Hughes Medical Institute and Department of Microbiology and Immunology, University of California, 513 Parnassus Avenue, San Francisco, CA 94143-0414, USA. ansel@itsa.ucsf.edu
K M
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Ansel
J G
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Cyster
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000378:metabolism; D054377:Chemokine CXCL12; D018925:Chemokines / Q000378:metabolism*; D019743:Chemokines, CXC / Q000378:metabolism; D004627:Embryonic Induction; D005314:Embryonic and Fetal Development; D006801:Humans; D008208:Lymphatic System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology / Q000378:metabolism
C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D018925:Chemokines; D019743:Chemokines, CXC