Haemoconcentration, shear-stress increase and carotid artery diameter regulation after furosemide administration in older hypertensives.
The aim of the present study was to determine whether changes of carotid wall shear stress induced by changes in blood viscosity after diuretic administration cause carotid arterial dilatation in elderly hypertensives, as reported in the cat. Arterial wall shear rate (ultrasound technique, profilmeter FRP III), the systo-diastolic diameter (echotracking technique) and the mean blood flow velocity and volume of the common carotid artery, the blood viscosity (rotational viscometer) and the finger arterial blood pressure (Finapress Ohmeda) were measured in 12 young volunteers (aged 25+/-2 years) and in 12 elderly hypertensives (aged 80+/-4 years) treated with short-acting calcium antagonists up to 24h before the study, both at baseline and after intravenous furosemide infusion (0.5mg/min), when the haematocrit had increased by at least two percentage points. After furosemide administration the mean arterial blood pressure decreased and blood viscosity and carotid systolic shear stress increased in both groups. However, common carotid artery diameter increased only in the young controls but not in the elderly hypertensives. These data show that an increase in carotid shear stress caused by haemoconcentration induces carotid vasodilatation only in young healthy subjects, and not in elderly hypertensives. This effect may be related to impaired endothelium function and/or arterial wall mechanics.
Fazio
M
M
Department of Clinical Medicine, c/o Ospedale di Cattinara, U.C.O. di Medicina Clinica, University of Trieste, Strada di Fiume 447, 34149, Trieste, Italy.
Bardelli
M
M
Cominotto
F
F
Fiammengo
F
F
Fabris
B
B
Fischetti
F
F
Candido
R
R
Pascazio
L
L
Lapasin
R
R
Carretta
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects; D017536:Carotid Artery, Common / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D002415:Cats; D004232:Diuretics / Q000494:pharmacology; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D013314:Stress, Mechanical; D014664:Vasodilation / Q000187:drug effects* / Q000502:physiology
D004232:Diuretics; D005665:Furosemide