Pathophysiological effects of low dietary phosphorus in pigs.
The homeostasis of inorganic phosphate (P(i)) is regulated by parathyroid hormone (PTH), 1,25-dihydroxyvitamin D (1,25(OH)(2)D), and P(i)itself in the intestine, kidney, and bone in all the mammalian species studied. Determinations of the serum concentrations of PTH, 1,25(OH)(2)D and osteocalcin were done in 82 southern Romanian Landrace pigs originating from three herds with dietary P(i)deficiency. Serum P(i)concentrations were negatively correlated with those of 1,25(OH)(2)D. In lactating animals and sucklings, the linear relationships between P(i)and 1,25(OH)(2)D were not present. Serum P(i)concentrations were positively correlated with those of PTH. In lactating animals and young pigs, the linear relationships between P(i)and PTH were not evident. PTH and 1,25(OH)(2)D concentrations were negatively correlated. The serum concentrations of 1,25(OH)(2)D and osteocalcin were positively correlated. Milk P(i)concentrations ranging from 3.10 to 7.49 mmol/L were correlated positively with urinary P(i)concentrations ranging from 0.26 to 11.37 mmol/L. In conclusion, similarly to other species, P(i)homeostasis is achieved in pigs by feedback mechanisms between P(i), PTH and 1,25(OH)(2)D and osteocalcin production is induced by 1,25(OH)(2)D. The effect of lactation on P(i)homeostasis remains to be explored.
Institute of Animal Nutrition, University of Zürich, Winterthurerstrasse 260, CH-8057 Zürich, Switzerland. jriond@vetphys.unizh.ch
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D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002118:Calcium / Q000097:blood; D006706:Homeostasis; D008274:Magnesium / Q000097:blood; D015675:Osteocalcin / Q000096:biosynthesis / Q000097:blood; D010018:Osteomalacia / Q000503:physiopathology / Q000662:veterinary; D010281:Parathyroid Hormone / Q000097:blood / Q000502:physiology; D010710:Phosphates / Q000097:blood / Q000378:metabolism*; D016226:Phosphorus, Dietary / Q000008:administration & dosage*; D012279:Rickets / Q000503:physiopathology / Q000662:veterinary; D012383:Romania; D013552:Swine / Q000378:metabolism / Q000502:physiology*; D013553:Swine Diseases / Q000503:physiopathology; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000502:physiology
D010281:Parathyroid Hormone; D010710:Phosphates; D016226:Phosphorus, Dietary; D015675:Osteocalcin; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; D008274:Magnesium; D002118:Calcium