Peroxynitrite-mediated mitochondrial dysfunction.
Peroxynitrite anion (ONOO(-)) is a potent biological oxidant produced by the near diffusion-limited reaction of superoxide and nitric oxide. Peroxynitrite has been implicated in diverse forms of free radical-induced tissue injury. Experimental evidence showed that exogenous and endogenous peroxynitrite causes alterations of the structure and function of mitochondrial proteins, leading to mitochondrial dysfunction and cellular or organ injury. These data are discussed along with its physiopathological implications.
Boczkowski
J
J
Institut National de la Santé et de la Recherche Médicale U408 and IFR 02, Faculté X. Bichat, Paris, France. jbb2@bichat.inserm.fr
Lisdero
C L
CL
Lanone
S
S
Carreras
M C
MC
Aubier
M
M
Poderoso
J J
JJ
D004734:Energy Metabolism / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects / Q000502:physiology*; D009566:Nitrates / Q000494:pharmacology*; D009569:Nitric Oxide / Q000378:metabolism*; D016877:Oxidants / Q000494:pharmacology*; D018384:Oxidative Stress; D010101:Oxygen Consumption / Q000187:drug effects
D009566:Nitrates; D016877:Oxidants; C039642:peroxynitric acid; D009569:Nitric Oxide