[Splenic thrombosis and celiac disease: a fortuitous association?].
BACKGROUND
Rare cases of venous thrombosis associated with celiac disease have been reported.


METHODS
We report a case of 40-year-old woman with splenic infarction and splenic venous thrombosis associated with celiac disease. This patient was homozygous for the C677T mutation of the methyltetrahydrofolate reductase (MTHFR) gene and had moderately elevated homocysteinemia.


CONCLUSIONS
We discuss the link between celiac disease and thrombosis as well as the interest and appropriate duration of anticoagulation and hypothesize a mechanism of thrombotic disease in this setting with hyperhomocyseinemia.
Service de Médecine interne et Nutrition, Hôpitaux Universitaires de Strasbourg. emmanuel.andres@chru-strasbourg.fr
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Andrès
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Pflumio
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Knab
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Muller
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Ott
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Ubrich
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Baumann
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Geisler
D015746:Abdominal Pain / Q000209:etiology; D000328:Adult; D002446:Celiac Disease / Q000150:complications* / Q000235:genetics*; D005260:Female; D006720:Homozygote; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications / Q000235:genetics; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009154:Mutation / Q000235:genetics; D009325:Nausea / Q000209:etiology; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics; D013159:Splenic Infarction; D013162:Splenic Vein; D014057:Tomography, X-Ray Computed; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*; D014839:Vomiting / Q000209:etiology
D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)