Cryofibrinogenemia and skin necrosis in a patient with diffuse large cell lymphoma after high-dose chemotherapy and autologous stem cell transplantation.
A 34-year-old woman with diffuse mediastinal B cell large cell lymphoma presented 60 days after high-dose chemotherapy and autologous stem cell transplantation, and post-transplant immunotherapy with interleukin-2, with skin necrosis in the ears and extremities. Extensive work-up revealed the presence of cryofibrinogenemia and associated thrombotic vasculopathy. The patient was successfully treated with corticosteroids and therapeutic plasma exchange. However, she had recurrence of large cell lymphoma a few weeks later and died of progressive disease. Cryfibrinogenemia and skin necrosis may have occurred secondary to the imminent relapse, or as a rare complication of high-dose chemotherapy or treatment with interleukin-2.
The Department of Blood and Marrow Transplantation, The University of Texas MD Anderson Cancer Center, Houston 77030, USA.
A
A
Shimoni
M
M
Körbling
R
R
Champlin
J
J
Molldrem
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D003449:Cryoglobulinemia / Q000209:etiology* / Q000473:pathology; D003450:Cryoglobulins / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D015241:Fibrinogens, Abnormal / Q000009:adverse effects; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016403:Lymphoma, Large B-Cell, Diffuse / Q000150:complications* / Q000628:therapy; D009336:Necrosis; D012008:Recurrence; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D014182:Transplantation, Autologous
D003450:Cryoglobulins; D015241:Fibrinogens, Abnormal; C041874:cryofibrinogen