Reactivation of primary hypertrophic osteoarthropathy by bronchogenic carcinoma.
This paper reports 2 cases of primary hypertrophic osteoarthopathy (PHO) which evolved into secondary hypertrophic osteoarthopathy (SHO) under the influence of bronchogenic carcinoma. The patients had a clinical picture of primary hypertrophic osteoarthropathy but without any signs of disease activity until in the last several months when a malignant bronchopulmonary condition developed. This activated all the symptoms: joint swelling; enlarged fingers and distal forearms and legs; moist palms and soles; unpleasant odour of perspiration; and deeper folds of the forehead and nasolabial furrow. A bone scan showed increased accumulation of the radioisotope in specific regions of the skeleton. To our knowledge, no similar cases have been described in the literature.
Jajic
Z
Z
Department for Rheumatology, Physical Medicine and Rehabilitation, Sestre Milosrdnice University Hospital, Zagreb, Croatia.
Grazio
S
S
Nemcic
T
T
Jajic
I
I
D002283:Carcinoma, Bronchogenic / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010004:Osteoarthropathy, Primary Hypertrophic / Q000150:complications*; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology