[Development of endothelial cell number in the host corneal endothelium. Status after block excision and eccentric corneal scleroplasty].
OBJECTIVE
Block excision of anterior uveal tumors and cystic epithelial ingrowth to the anterior chamber is a curative treatment for morphological rehabilitation of the globe. This study quantified the course of the host corneal endothelium after this peripheral corneoscleral graft.


METHODS
This retrospective cross-sectional study examined 53 specular microscopic photographs of the central host cornea in 30 patients. The diameter of the block excision was 8.5 +/- 1.9 mm (6.0-11.0 mm). Follow-up after surgery averaged 37.9 +/- 47.6 months (1-216).


RESULTS
The corneal endothelial cell count decreased with the duration of follow-up after block excision. The cell count was not related to indication for surgery or to diameter of block excision. Mean visual acuity was 16/20 before block excision and 6/20 at the end of follow-up.


CONCLUSIONS
There is a significant loss of endothelial cells of the host after block excision, requiring a second central penetrating keratoplasty in some patients. Loss of endothelial cells may be due to the surgical trauma, chronic immunological reaction against the donor endothelium, or migration of the host endothelial cells onto the corneoscleral graft.
Augenklinik mit Poliklinik, Universität Erlangen-Nürnberg, Schwabachanlage 6, 91054 Erlangen. michael.groh@augen.imed.uni-erlangen.de
M J
MJ
Groh
B
B
Seitz
G O
GO
Naumann
D000328:Adult; D000368:Aged; D002452:Cell Count; D016039:Corneal Transplantation; D003430:Cross-Sectional Studies; D003560:Cysts / Q000473:pathology / Q000601:surgery*; D004728:Endothelium, Corneal / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000473:pathology*; D012189:Retrospective Studies; D014604:Uveal Neoplasms / Q000473:pathology / Q000601:surgery*; D014792:Visual Acuity / Q000502:physiology