Application of f--f luminescence of terbium ion for determination of non-steroidal anti-inflammatory drug-niflumic acid.
A simple, rapid and sensitive luminescence method for determination of niflumic acid (NFA) is described. The method is based on the intramolecular energy transfer from niflumic acid to terbium ion (Tb(3+)) in the presence of trioctylphosphine oxide (TOPO). Optimum conditions for the formation of the NFA-Tb(3+)-TOPO ternary complex have been investigated. The calibration graph is linear over the range 0.002--0.02 microg ml(-1). The relative standard deviation is close to 4%. The recoveries obtained by applying the method to the analysis of urine ranged from 94--102%.
Egorova
A
A
A.V. Bogatsky Physico-chemical Institute of the National Academy of Sciences of Ukraine, 86, Lustdorfskaya doroga, 65080, Odessa, Ukraine.
Beltyukova
S
S
Teslyuk
O
O
Karpinchik
V
V
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D002138:Calibration; D006801:Humans; D008163:Luminescent Measurements; D009544:Niflumic Acid / Q000032:analysis*; D012016:Reference Values; D015203:Reproducibility of Results; D013725:Terbium / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013725:Terbium; D009544:Niflumic Acid