Mucoadhesive nanoparticulate systems for peptide drug delivery.
This chapter describes the preparation of and methods for evaluating mucoadhesive nanoparticulate systems, including liposomes and polymeric nanoparticles. Mucoadhesive ability is conferred on the particulate systems by coating their surface with mucoadhesive polymers such as chitosan and Carbopol. The feasibility of this surface modification was confirmed by measuring the zeta potential. Several methods of evaluating the mucoadhesive properties of particulate systems have been reported in the literature. We have also developed some novel evaluation procedures including a particle counting method using a Coulter counter for polymer-coated liposomes. The mucoadhesive properties of the polymer-coated liposomes and polymeric nanoparticles were confirmed by means of these mucoadhesion tests. In applying these mucoadhesive nanoparticles to the oral and pulmonary administration of peptide drugs, more effective and prolonged action was observed in comparison with non-coated systems, thereby confirming the usefulness of mucoadhesive nanoparticulate systems for the delivery of peptide drugs.
Department of Pharmaceutical Engineering, Gifu Pharmaceutical University, 5-6-1 Mitahora-higashi, Gifu 502-8585, Japan.
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Takeuchi
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Yamamoto
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Kawashima
D000818:Animals; D001672:Biocompatible Materials; D002686:Chitin / Q000031:analogs & derivatives; D048271:Chitosan; D003102:Colloids; D004337:Drug Carriers / Q000008:administration & dosage / Q000737:chemistry*; D005753:Gastric Mucosa / Q000187:drug effects / Q000502:physiology; D006168:Guinea Pigs; D007408:Intestinal Absorption / Q000187:drug effects / Q000502:physiology; D019344:Lactic Acid / Q000008:administration & dosage / Q000737:chemistry*; D008081:Liposomes; D008297:Male; D009330:Nebulizers and Vaporizers; D010455:Peptides / Q000008:administration & dosage / Q000737:chemistry*; D011100:Polyglycolic Acid / Q000008:administration & dosage / Q000737:chemistry*; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers / Q000008:administration & dosage / Q000737:chemistry*; D051381:Rats
D001672:Biocompatible Materials; D003102:Colloids; D004337:Drug Carriers; D008081:Liposomes; D010455:Peptides; D011108:Polymers; D002686:Chitin; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D048271:Chitosan