Resveratrol decreases hyperalgesia induced by carrageenan in the rat hind paw.
The effect of resveratrol, an aryl hydrocarbon receptor (AhR) antagonist, known to inhibit inducible cyclooxygenase-2 (COX2) and its transcription were examined in a model of hyperalgesia induced by carrageenan in the rat. Pretreatment with resveratrol did not reverse swelling and edema, but reversed the hyperalgesia induced by local tissue injury provoked by carrageenan. This reversal, occurring at resveratrol concentrations as low as 2 mg/kg, lasted for at least 48 hours. The link with COX2 activity inhibition and COX2 gene transcription, as well as a potential AhR inhibitory effect, remain to be established.
Gentilli
M
M
Université de Paris-Sud: Laboratoire d'Anésthesie, UPRES EA392 Faculté de Médecine du Kremlin-Bicêtre, Le Kremlin-Bicêtre, France.
Mazoit
J X
JX
Bouaziz
H
H
Fletcher
D
D
Casper
R F
RF
Benhamou
D
D
Savouret
J F
JF
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002351:Carrageenan; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced; D005528:Foot; D006614:Hindlimb; D006930:Hyperalgesia / Q000139:chemically induced / Q000188:drug therapy*; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008297:Male; D010147:Pain Measurement; D011451:Prostaglandin-Endoperoxide Synthases; D051381:Rats; D017207:Rats, Sprague-Dawley; D018336:Receptors, Aryl Hydrocarbon / Q000037:antagonists & inhibitors; D000077185:Resveratrol; D013267:Stilbenes / Q000627:therapeutic use*; D014828:Vocalization, Animal
D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D018336:Receptors, Aryl Hydrocarbon; D013267:Stilbenes; D002351:Carrageenan; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D000077185:Resveratrol