Markedly elevated levels of vascular endothelial growth factor, fibroblast growth factor, and interleukin 6 in Meigs syndrome.
Analysis of serum and peritoneal and pleural fluid from a patient with Meigs' syndrome revealed high levels of vascular endothelial growth factor, fibroblast growth factor, and interleukin 6. Serum levels declined after removal of the ovarian tumor, along with resolution of ascites and hydrothorax. These findings suggest the involvement of these vasoactive factors in ascites and pleural fluid formation in Meigs' syndrome.
Department of Obstetrics and Gynecology and the Immunology Laboratory for Tumor Diagnosis, Hadassah Hebrew University Medical Center, Jerusalem, Israel.
Y
Y
Abramov
S O
SO
Anteby
S J
SJ
Fasouliotis
V
V
Barak
D001201:Ascites / Q000378:metabolism; D001202:Ascitic Fluid / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000097:blood / Q000378:metabolism*; D005260:Female; D005346:Fibroblast Growth Factors / Q000097:blood / Q000378:metabolism*; D006651:Histocytochemistry; D006801:Humans; D007044:Hysterectomy; D007124:Immunoenzyme Techniques; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism*; D008222:Lymphokines / Q000097:blood / Q000378:metabolism*; D008539:Meigs Syndrome / Q000097:blood / Q000378:metabolism* / Q000601:surgery; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000378:metabolism; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D015850:Interleukin-6; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D005346:Fibroblast Growth Factors