Comparison of hypotonic and isotonic solutions containing sodium hyaluronate on the symptomatic treatment of dry eye patients.
This study was designed to compare the efficacy of two artificial tears both containing hyaluronic acid but differing in their osmolarity. A multicentric double-masked, crossover clinical trial was performed in which 158 subjects were randomized to receive either hypotonic or isotonic artificial tears up to 6 times a day. Both treatments were effective in improving signs and symptoms to a similar extent. No adverse events were reported. It was concluded that hypotonic and isotonic eye drops are comparable for the symptomatic treatment of patients suffering from dry eye syndrome.
Medical Department SIFI SpA, Lavinaio (Catania), Italy.
V
V
Papa
P
P
Aragona
S
S
Russo
A
A
Di Bella
P
P
Russo
G
G
Milazzo
D018592:Cross-Over Studies; D004311:Double-Blind Method; D015352:Dry Eye Syndromes / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage* / Q000009:adverse effects; D007038:Hypotonic Solutions; D007552:Isotonic Solutions; D009883:Ophthalmic Solutions / Q000008:administration & dosage* / Q000009:adverse effects; D009994:Osmolar Concentration; D013666:Tears / Q000502:physiology; D016896:Treatment Outcome
D007038:Hypotonic Solutions; D007552:Isotonic Solutions; D009883:Ophthalmic Solutions; D006820:Hyaluronic Acid