KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models.
KF19418, a newly synthesized compound, stimulated proliferation of cultured hair bulb cells from new born mice in concentration-dependent manner in the range under 10 microM. In the culture system of whole skin pieces from 4-week-old mice which we earlier established, KF19418 promoted hair follicle elongation as in the case of minoxidil. After topical application for 2 weeks of KF19418 or minoxidil to dorsal skin of hair-clipped mouse alopecia model, KF19418 at 1% suspension accelerated hair regrowth at a rate comparable to 1% minoxidil solution. Thus, it was shown that KF19418 directly stimulated hair follicle in vitro and had hair growth promoting activities in vivo.
Shirai
A
A
Kyowa Hakko Kogyo Co., Ltd., Tokyo Research Laboratories, Tokyo, Japan. akio.shirai@kyowa.co.jp
Ikeda
J
J
Kawashima
S
S
Tamaoki
T
T
Kamiya
T
T
D000505:Alopecia / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D002478:Cells, Cultured; D046508:Culture Techniques; D003879:Dermatologic Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006197:Hair / Q000187:drug effects* / Q000254:growth & development*; D018859:Hair Follicle / Q000187:drug effects / Q000254:growth & development; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008914:Minoxidil / Q000494:pharmacology
D003879:Dermatologic Agents; D006575:Heterocyclic Compounds, 3-Ring; C429325:KF19418; D008914:Minoxidil