[Use of the expression coefficient to evaluate the effect of various substances on HIV-1 in vitro].
The effect of some saponins (taurosides) and muramyl peptides (MDP and cholesteryl-MDP) on HIV-1 reproduction in Jurkat-tat T cells was studied by the coefficient of the virus expression CE. CE was calculated as ratio of concentration of HIV p24 to the amount of viable cells. Various substances caused diverse effects on HIV-1 propagation (taurosid I and cholesteryl-MDP possessed potent antiviral and HIV-stimulating properties respectively). The effectiveness of the CE usage for detection of HIV-modulating characteristics of various substances was discussed.
Krivorutchenko
Iu L
IuL
Crimean Medical University, Department of Microbiology, 5/7 Lenin Blvd., Simferopol, Crimea, 95006, Ukraine.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D002470:Cell Survival; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D016655:HIV Core Protein p24 / Q000096:biosynthesis; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D019169:Jurkat Cells; D012503:Saponins / Q000494:pharmacology*; D014779:Virus Replication
D000276:Adjuvants, Immunologic; D016655:HIV Core Protein p24; D012503:Saponins; D000119:Acetylmuramyl-Alanyl-Isoglutamine