No increased human herpesvirus 8 seroprevalence in patients with HIV-associated non-Hodgkin's lymphoma.
Human herpesvirus 8 (HHV-8) is closely associated with Kaposi's sarcoma (KS), HIV-associated Castleman's disease, and primary effusion lymphoma. As a high frequency of non-Hodgkin's lymphoma (NHL) has been reported in patients with HIV-associated KS, we hypothesized that HHV-8 infection could be indirectly implicated in the pathogenesis of NHL. We assessed the prevalence of HHV-8 antibodies in 63 patients with NHL compared with 126 HIV-infected matched control patients without NHL. Serum samples from cases and controls were assayed for antibodies to HHV-8 lytic and latent antigens using an indirect immunofluorescence assay. In patients with concordant serologic results, HHV-8 antibodies were detected in 41.5% of the NHL cases and 37% of the controls. This absence of a significant difference in HHV-8 seroprevalence between cases and controls (p =.73) does not support a possible role for HHV-8 infection in the development of NHL in HIV-infected patients.
Department of Immunology and Hematology, Hôpital Saint-Louis, Paris, France. laurence. gerard@sls.ap-hop-paris.fr
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L
Gérard
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Agbalika
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Sheldon
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Maillard
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Schulz
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Oksenhendler
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000821:virology; D019288:Herpesvirus 8, Human / Q000276:immunology; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000453:epidemiology / Q000821:virology; D008297:Male; D008875:Middle Aged; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral