Independence of firing correlates of anatomically proximate hippocampal pyramidal cells.
In neocortex, neighboring neurons frequently exhibit correlated encoding properties. There is conflicting evidence whether a similar phenomenon occurs in hippocampus. To assess this quantitatively, a comparison was made of the spatial and temporal firing correlations within and between local groups of hippocampal cells, spaced 350-1400 microm apart. No evidence of clustering was found in a sample of >3000 neurons. Moreover, cells active in two environments were uniformly interspersed at a scale of <100 microm, as assessed by the activity-induced gene Arc. Independence of encoding characteristics implies uncorrelated inputs, which could enhance the capacity of the hippocampus to store arbitrary associations.
Redish
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AD
Division of Neural Systems, Memory, and Aging, Arizona Research Laboratories, University of Arizona, Tucson, Arizona 85724, USA.
Battaglia
F P
FP
Chawla
M K
MK
Ekstrom
A D
AD
Gerrard
J L
JL
Lipa
P
P
Rosenzweig
E S
ES
Worley
P F
PF
Guzowski
J F
JF
McNaughton
B L
BL
Barnes
C A
CA
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004777:Environment; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D007395:Interneurons / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008474:Medial Forebrain Bundle / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D017966:Pyramidal Cells / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D012815:Signal Processing, Computer-Assisted; D013037:Spatial Behavior / Q000502:physiology
D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C092069:activity regulated cytoskeletal-associated protein