Pseudomonas aeruginosa and the in vitro and in vivo biofilm mode of growth.
The biofilm mode of growth is the survival strategy of environmental bacteria like Pseudomonas aeruginosa. Such P. aeruginosa biofilms also occur in the lungs of chronically infected cystic fibrosis patients, where they protect the bacteria against antibiotics and the immune response. The lung tissue damage is due to immune complex mediated chronic inflammation dominated by polymorphonuclear leukocytes releasing proteases and oxygen radicals.
Høiby
N
N
Department of Clinical Microbiology 9301, Rigshospitalet and Institute of Medical Microbiology and Immunology, Juliane Maries Vej 22, University of Copenhagen, DK-2100, Copenhagen, Denmark. hoiby@inet.uni2.dk
Krogh Johansen
H
H
Moser
C
C
Song
Z
Z
Ciofu
O
O
Kharazmi
A
A
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018441:Biofilms; D002908:Chronic Disease; D003550:Cystic Fibrosis / Q000276:immunology / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008168:Lung / Q000382:microbiology / Q000473:pathology; D009504:Neutrophils / Q000378:metabolism; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000502:physiology*
D000900:Anti-Bacterial Agents; D010450:Endopeptidases