Synthesis and antiviral activity of novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines.
Novel D- and L-2'-azido-2',3'-dideoxyribofuranosyl-4'-thiopyrimidines and purines have been synthesized starting from L-xylose and D-xylose, respectively. Among synthesized compounds tested against several viruses such as HIV-1, HSV-1, HSV-2, and HCMV, D-beta-N6-methyladenine (ent-22a) and D-alpha-N6-methyladenine (ent-22b) analogues were found to exhibit significant anti-HCMV activity.
Kim
H O
HO
College of Medicine, Yonsei University, Seoul, South Korea.
Kim
Y H
YH
Suh
H
H
Jeong
L S
LS
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013872:Thionucleosides / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D013872:Thionucleosides