Tc-99m DTPA renography in patients with collagen disease.
OBJECTIVE
This study evaluated the use of Tc-99m DTPA renography in patients with collagen disease.


METHODS
Tc-99m DTPA renal scintigraphy was performed in 28 patients with clinically diagnosed collagen disease. Twenty-two other patients who underwent renal scintigraphy and were subsequently shown to have no kidney abnormalities served as the control group.


RESULTS
One quarter of the patients with collagen disease had abnormal findings of renography, despite the absence of abnormal laboratory data. Renograms were 100% sensitive for the detection of renal disease in patients with collagen disease, and their specificity was 53% when serum blood urea nitrogen, serum creatinine concentration, and proteinuria were the only measures of renal impairment considered. The glomerular filtration rate was not significantly different between the groups, but the bilateral time to peak was significantly greater in the patients with collagen disease. Hydronephrosis was present in 7% of patients with collagen disease.


CONCLUSIONS
Renography is useful for detecting early changes of renal involvement when the clinical state of collagen disease is evaluated.
Department of Radiology, Tokyo Medical and Dental University, Japan. m-tezuka@st.rim.or.jp
M
M
Tezuka
Y
Y
Murata
R
R
Ishida
Y
Y
Sawada
H
H
Shibuya
D000328:Adult; D016022:Case-Control Studies; D003095:Collagen Diseases / Q000000981:diagnostic imaging*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006869:Hydronephrosis / Q000175:diagnosis / Q000209:etiology; D007674:Kidney Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000209:etiology; D008297:Male; D011866:Radioisotope Renography; D012680:Sensitivity and Specificity; D016284:Technetium Tc 99m Pentetate
D016284:Technetium Tc 99m Pentetate