[Comparison of pharmacological effects between cultispecies Sichuan Fritillary bulb (F. wabueasis, F. mellea) and wild Sichuan Fritillary bulb (F. unibracteata)].
The ethanol extracts from the cultured Sichuan Fritillary bulb have been proved similar to those from the wild one in treating coughing in mice, expectoration in rats, asthma in guinea pigs, bronchodilation of isolated lungs in mice, and cyclic nucleotide(cAMP, cGMP) in the plasma and lungs of mice. The acute toxicity of the cultured and wild species is also similar to each other. However, in terms of asthma relieving and cAMP level increment in the lungs, the cultured species F. wabueasis is significantly superior to the wild species of Fritillary bulb.
School of Pharmacy, West China University of Medical Sciences, Chengdu 610041.
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D000818:Animals; D018927:Anti-Asthmatic Agents / Q000494:pharmacology; D000996:Antitussive Agents / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005100:Expectorants / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D019668:Liliaceae / Q000145:classification; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000145:classification; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D018927:Anti-Asthmatic Agents; D000996:Antitussive Agents; D004365:Drugs, Chinese Herbal; D005100:Expectorants