Coenzyme Q10, vitamin E, and dihydrothioctic acid cooperatively prevent diene conjugation in isolated low-density lipoprotein.
Coenzyme Q (Q10) and alpha-tocopherol cooperatively delay the onset of diene conjugation in isolated human low density lipoprotein if supplied in water-soluble preparations to blood serum. Both copper ions and morpholino sydnonimine (in the presence of glucose; SIN-1-glucose) -driven diene conjugation is measurable as soon as both reduced Q10 and tocopherol are oxidized, where tocopherol oxidation starts after 80-90% consumption of reduced Q10. LDL-bound Q10 in turn can be rapidly reduced by dihydrolipoic acid (thioctic acid). This reaction is at least 10 times faster than reduction by ascorbic acid.
Institute of Phytopathology, Department of Applied Biochemistry, Technical University Munich, Freising-Weihenstephen, Germany.
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Schneider
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Elstner
D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D003067:Coenzymes; D003300:Copper / Q000494:pharmacology; D006801:Humans; D007477:Ions / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D008981:Molsidomine / Q000031:analogs & derivatives / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism; D011485:Protein Binding; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D003067:Coenzymes; D007477:Ions; D008077:Lipoproteins, LDL; D020030:Nitric Oxide Donors; D014451:Ubiquinone; D014810:Vitamin E; C002385:linsidomine; D008063:Thioctic Acid; D003300:Copper; C015144:dihydrolipoic acid; D008981:Molsidomine; C024989:coenzyme Q10; D001205:Ascorbic Acid; D010100:Oxygen