Electrophysiological measures of auditory function in the neurofilament-deficient mutant quail (Quv).
Auditory pathway electrophysiological studies were performed on the mutant quail 'Quv'. This mutation is known to result in neurofilament deficiencies of both the peripheral and central nervous systems. Auditory evoked brainstem responses (ABRs), electrocochleograms (EcochGs) and middle latency responses (MLRs) were evaluated. ABRs in Quv quails demonstrated markedly altered waveforms exhibiting longer latencies, absence of the later peaks and lower amplitudes. The EcochG showed normal cochlear microphonics with no obvious abnormalities in amplitude or latency and normal latencies for peak N1. Quv quails had a mild threshold elevation with a normal latency for the first peak of the ABR (P1). The Quv MLRs showed no significant differences in amplitude but they revealed a latency prolongation for peaks N0, Pa and Na relative to the controls. We have discovered abnormal findings of auditory evoked potentials in the neurofilament-deficient quail (Quv). We suggest that the smaller axonal size and axonal hypotrophy due to altered neurofilament expression underlies these abnormal auditory evoked potential responses.
Sheykholeslami
K
K
Department of Otolaryngology, University of Tokyo, Japan. kianoush@m.u-tokyo.ac.jp
Kaga
K
K
Tsuzuku
T
T
Mizutani
M
M
D000161:Acoustic Stimulation; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology; D001309:Auditory Threshold; D001369:Axons / Q000473:pathology / Q000502:physiology; D003370:Coturnix / Q000235:genetics* / Q000502:physiology*; D004594:Electrophysiology; D005072:Evoked Potentials, Auditory / Q000502:physiology; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D009154:Mutation