Glucose transport and apoptosis.
The transport and metabolism of glucose modify programmed cell death in a number of different cell types. This review presents three cell death paradigms that link a decrease in glucose transport to apoptosis. Although these pathways overlap, the glucose-dependent stimuli that trigger cell death differ. These paradigms include glucose deprivation-induced ATP depletion and stimulation of the mitochondrial death pathway cascade; glucose deprivation-induced oxidative stress and triggering of Bax-associated events including the JNK/MAPK signalling pathways; and finally hypoglycemia-regulated expression of HIF-1 alpha, stabilization of p53 leading to an increase in p53-associated apoptosis. Several examples of each paradigm are presented. Future studies of glucose transport-associated apoptotic events will allow better understanding of the role of cellular metabolism in programmed cell death.
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.
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Moley
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Mueckler
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000544:Alzheimer Disease / Q000503:physiopathology; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001692:Biological Transport; D015687:Cell Hypoxia; D002478:Cells, Cultured; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D015398:Signal Transduction
D000255:Adenosine Triphosphate; D005947:Glucose