Disturbed surface properties in preterm infants with pneumonia.
Congenital pneumonia in preterm infants is often associated with respiratory insufficiency requiring mechanical ventilation. This study was performed to show whether pneumonia in these infants is associated with an inhibition or deficiency of surfactant. The ratio of lecithin and sphingomyelin (L/S ratio) and minimal surface tension were determined in pharyngeal aspirates from 90 term born infants (healthy) and in tracheal aspirates from preterm infants with wet lung (n = 13), congenital pneumonia (n = 21) and respiratory distress syndrome (RDS) (n = 90). The L/S ratio was lower (p < 0.0001) in the RDS group (8.6) when compared with healthy (48.6), wet lung (42.9) and pneumonia (28.9). Surface tension was higher (p < 0.001) in RDS (37 mN/m) and pneumonia (33.7) when compared with healthy (22.9) or wet lung (21.2). For infants with RDS, L/S ratio <16.5 detects surfactant deficiency with 96% specificity and 70% sensitivity, surface tension >29 mN/m represents surfactant inhibition (specificity 97%, sensitivity 92%). Using these cut-off values in infants with pneumonia, 81% had a sufficient amount of surfactant but only 21% of infants with pneumonia had appropriate surface tension. Our study shows that lung effluent of respiratory insufficient infants with pneumonia, who need mechanical ventilation, has disturbed surface properties despite a sufficient amount of surfactant. In these infants, surfactant substitution could be beneficial.
Otto Heubner Center for Pediatrics, Clinic of Neonatology, Charité Campus Mitte, Hospital of Humboldt University, Berlin, Germany. mario.ruediger@rz.hu-berlin.de
M
M
Rüdiger
W
W
Friedrich
B
B
Rüstow
G
G
Schmalisch
R
R
Wauer
D016022:Case-Control Studies; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008168:Lung / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D011014:Pneumonia / Q000151:congenital / Q000503:physiopathology*; D011446:Prospective Studies; D011663:Pulmonary Surfactants / Q000502:physiology*; D012016:Reference Values; D012127:Respiratory Distress Syndrome, Newborn / Q000503:physiopathology; D013109:Sphingomyelins / Q000378:metabolism; D013500:Surface Tension
D010713:Phosphatidylcholines; D011663:Pulmonary Surfactants; D013109:Sphingomyelins