Are inflammation and immunological hyperactivity needed for filarial parasite development?
Immune-dependent growth and development of infectious agents and pathogenesis of disease are increasingly being recognized. It is proposed that the development of filarial larvae to adult stage parasites takes place in an ambiance of inflammatory T helper cell type 1 cytokines in mammalian hosts, and that susceptibility to filarial infections could be governed by the status of macrophage-derived nitric oxide and host ability to produce antibodies to filarial T-independent (carbohydrate) antigens.
Ravindran
B
B
Division of Immunology, Regional Medical Research Centre, Indian Council of Medical Research (ICMR), Bhubaneswar-751023, India. immunol@dte.vsnl.net.in
D000818:Animals; D005368:Filariasis / Q000276:immunology* / Q000662:veterinary*; D005370:Filarioidea / Q000254:growth & development* / Q000276:immunology; D007108:Immune Tolerance; D007814:Larva / Q000254:growth & development / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008322:Mammals / Q000276:immunology / Q000469:parasitology*; D018448:Models, Immunological; D018417:Th1 Cells / Q000276:immunology*