Protective effect of Prostane in experimental prostatic hyperplasia in rats.
OBJECTIVE
Prostane, a polyherbal formulation, was evaluated for its efficacy on 5alpha-reductase inhibition, alpha-adrenergic antagonistic activity and testosterone-induced prostatic hyperplasia.


METHODS
5alpha-reductase inhibition was evaluated using rat prostate homogenate as an enzyme source. Adrenergic antagonistic activity was evaluated using isolated rat vas deferens. Experimental prostatic hyperplasia was induced in rats by giving testosterone 3 mg/kg sc for 21 days.


RESULTS
Prostane dose-dependently inhibited 5alpha-reductase activity and exhibited alpha-adrenergic antagonistic activity. Treatment with Prostane at 250, 500 and 750 mg/kg body wt, po for 21 days significantly reduced the prostatic weight, the epithelial height and the stromal proliferation in experimental prostatic hypertrophy.


CONCLUSIONS
Prostane is effective in the treatment of experimental prostatic hypertrophy in rats and may be passed on to clinical trials on benign prostatic hypertrophy after necessary toxicological evaluations.
R&D Centre, The Himalaya Drug Co, Makali, Bangalore, India. skmitra@bgl.vsnl.net.in
S K
SK
Mitra
R
R
Sundaram
A R
AR
Mohan
S
S
Gopumadhavan
M V
MV
Venkataranganna
U
U
Venkatesha
S J
SJ
Seshadri
S D
SD
Anturlikar
D000818:Animals; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D010946:Plants, Medicinal / Q000627:therapeutic use*; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; C424244:Prostane, herbal preparation