[Correction of NO-dependent cardiovascular disorders by adaptation to hypoxia].
Spontaneously hypertensive rats (SHR-SP) were adapted to intermittent hypobaric hypoxia in an altitude chamber for 40 days. The adaptation to hypoxia prevented an excessive endothelium-dependent relaxation and hypotension characteristic of myocardial infarction. The adaptation also attenuated the increase in blood pressure and prevented impairment of the endothelium-dependent relaxation in SHR-SP. The universal nature of the adaptation allows to use it for correcting many cardiovascular disorders related to diverse alterations of NO metabolism.
Institute of General Pathology and Pathophysiology, Russian Acad. Med. Sci., Baltiyskaya St., 8, Moscow 125315, Russia.
S Iu
SIu
Mashina
B V
BV
Smirin
I Iu
IIu
Malyshev
N P
NP
Liamina
V N
VN
Senchikhin
D A
DA
Pokidyshev
E B
EB
Manukhina
D000222:Adaptation, Physiological; D000531:Altitude; D000818:Animals; D001011:Aorta / Q000503:physiopathology; D001794:Blood Pressure; D004730:Endothelium, Vascular / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology / Q000517:prevention & control*; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D009203:Myocardial Infarction / Q000503:physiopathology / Q000517:prevention & control*; D009569:Nitric Oxide; D010100:Oxygen / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar
D009569:Nitric Oxide; D010100:Oxygen