[Effect of pineal peptide on parameters of the biological age and life span in mice].
Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death. The drug failed to affect the body weight or food consumption, physical activity or behavioural parameters. However, it slowed down the age-related switching off of the estrus function, decreased body temperature, decelerated free redical processes, prolonged the mice life span with an accompanying drop in spontaneous tumour incidence.
Institute of Oncology, 189646, St. Petersburg, Pesochny-2, Russia.
V N
VN
Anisimov
V Kh
VKh
Khavinson
N Iu
NIu
Zavarzina
M A
MA
Zabezhinskiĭ
O A
OA
Zimina
I G
IG
Popovich
A V
AV
Shtylik
A V
AV
Arutiunian
T I
TI
Oparina
V M
VM
Prokopenko
D000375:Aging / Q000502:physiology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004971:Estrus / Q000187:drug effects; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D008136:Longevity / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009043:Motor Activity / Q000187:drug effects; D018763:Muscle Fatigue / Q000187:drug effects; D009369:Neoplasms / Q000517:prevention & control; D009842:Oligopeptides / Q000494:pharmacology*; D012098:Reproduction / Q000187:drug effects
D005609:Free Radicals; D009842:Oligopeptides; C421253:alanyl-glutamyl-aspartyl-glycine