Synthesis and anti-inflammatory activity of 1-acetyl-5-substituted aryl-3-(beta-aminonaphthyl)-2-pyrazolines and beta-(substituted aminoethyl) amidonaphthalenes.
The title compounds were prepared by reaction of beta-acetylamino-naphthalene with different aromatic aldehydes followed by cyclisation with hydrazine hydrate and with different primary or secondary amines (Mannich's reaction), respectively. The structures of new compounds were confirmed by 1H-NMR and IR spectral data. Anti-inflammatory and ulcerogenic activities in vivo were evaluated and compared with the standard drugs, phenylbutazone and indomethacin. Some compounds of the series exhibited promising anti-inflammatory activity with a lower ulcerogenic liability than the standard drugs.
Medicinal Chemistry Division, Department of Pharmacology, L.L.R.M. Medical College, 250004, U.P., Meerut, India.
E
E
Bansal
V K
VK
Srivastava
A
A
Kumar
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009281:Naphthalenes / Q000737:chemistry / Q000494:pharmacology; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D014456:Ulcer / Q000139:chemically induced / Q000473:pathology
D000893:Anti-Inflammatory Agents; D009281:Naphthalenes; D002599:Chalcone; D010653:Phenylbutazone; D007213:Indomethacin