Diagnosis of severe combined immunodeficiency.
Early diagnosis of severe combined immunodeficiency (SCID) is important to enable prompt referral to a supraregional centre for bone marrow transplantation before the occurrence of end organ damage secondary to infective complications. This review outlines clinical, microbiological, and immunopathological clues that aid the diagnosis of SCID and emphasises the multidisciplinary approach needed to diagnose and treat these infants.
Gennery
A R
AR
Department of Paediatric Immunology, Newcastle General Hospital, Newcastle upon Tyne, UK. ARGennery@aol.com
Cant
A J
AJ
D016026:Bone Marrow Transplantation; D006801:Humans; D007231:Infant, Newborn; D009894:Opportunistic Infections / Q000150:complications; D011379:Prognosis; D016511:Severe Combined Immunodeficiency / Q000150:complications / Q000175:diagnosis* / Q000628:therapy