Endoscopic findings of radiation esophagitis in concurrent chemoradiotherapy for intrathoracic malignancies.
OBJECTIVE
The incidence and extent of radiation esophagitis were assessed endoscopically in patients treated with concurrent chemoradiotherapy.


METHODS
Eighty-two patients who received thoracic radiotherapy for lung, thymic, or esophageal cancer were investigated endoscopically from July 1991 to the end of 1997. Among them, 23 esophageal cancer patients were treated with radiation alone, and the others were treated with concurrent chemoradiotherapy. Esophageal endoscopy was performed during or just after radiotherapy. The presence of radiation esophagitis was assessed and assigned an endoscopic score (i.e. grade 0 for normal, 1 for erythema, 2 for erosion or sloughing, 3 for ulcer, hemorrhage, or stricture). The symptomatic grade was assessed using the RTOG (Radiation Therapy Oncology Group) acute radiation morbidity score.


RESULTS
A correlation was seen between endoscopic and RTOG scores. However, even some patients with RTOG grade 0 to 1 had endoscopic grade 3 esophagitis. Endoscopic grade 3 was observed in 16 (27.1%) patients in the concurrent chemoradiotherapy group, whereas it did not occur in any patient in the radiation alone group (P=0.004).


CONCLUSIONS
Our results suggest that (1) RTOG score correlates closely to esophageal mucosal damage, and (2) more severe esophagitis occurs in those undergoing concurrent chemoradiotherapy than those undergoing radiotherapy alone [corrected].
Department of Radiology, Hyogo Medical Center for Adults, 13-70 Kitaojicho, Akashi 673-8558, Japan.
S
S
Hirota
K
K
Tsujino
Y
Y
Hishikawa
H
H
Watanabe
K
K
Kono
T
T
Soejima
K
K
Obayashi
Y
Y
Takada
M
M
Kono
M
M
Abe
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D004941:Esophagitis / Q000175:diagnosis* / Q000209:etiology; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000175:diagnosis*; D011879:Radiotherapy Dosage; D013899:Thoracic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D013953:Thymus Neoplasms / Q000188:drug therapy / Q000532:radiotherapy