[Bacterial L-asparaginase and glutamin(asparagin)ase: some properties, structure and anti-tumor activity].
Experimental material on structurally and functional organization, regulation of biosynthesis and activity, mechanism of action, genetic determinants, heterologous expression of bacterial L-asparaginases is accumulated. The modern approaches to isolation and purification of these enzymes, some questions of practical using in oncology in the schedules combined chemotherapy of leukemia the native and modified forms of L-asparaginases are discussed. The some results before carried out in the IBMC RAMS and number institutes of the Russia on study bacterial L-asparaginases and glutamine(asparagine)ases are summarized.
Sokolov
N N
NN
Orechovich Institute of Biomedical Chemistry RAMS, Pogodinskaya 10, Moscow, 119832. sokolov@medic.ibmh.msk.su
Zanin
V A
VA
Aleksandrova
S S
SS
D000581:Amidohydrolases / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001215:Asparaginase / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004885:Erwinia / Q000201:enzymology*; D004926:Escherichia coli / Q000201:enzymology*; D011487:Protein Conformation
D000970:Antineoplastic Agents; D000581:Amidohydrolases; D001215:Asparaginase; C020654:glutamin-(asparagin-)ase