Lewis and Secretor gene effects on Lewis antigen and postnatal development of Lewis blood type.
Lewis (Le) and Secretor (Se) gene effects on postnatal change in Lewis antigens are described based on the quantitative analysis of Lewis antigens in blood. Genuine Lewis blood types were determined by Le and Se genotyping in DNA samples obtained from umbilical cord blood and infant blood. Lewis(a) (Le(a)) and Lewis(b) (Le(b)) antigen levels were measured by a time-resolved fluoroimmunoassay. We found that Lewis phenotypes in infants over 9 months of age agreed with the genuine types. In cord blood, the dosage effect of the Se gene on antigen levels was observed, but the Le gene effect was not observed. Both Se and Le gene effects were observed in newborn babies' blood 3-6 days after birth.
Ameno
S
S
Department of Forensic Medicine, Faculty of Medicine, Kagawa Medical University, Kagawa, Japan. amenos@kms.ac.jp
Kimura
H
H
Ameno
K
K
Zhang
X
X
Kinoshita
H
H
Kubota
T
T
Ijiri
I
I
D000375:Aging / Q000097:blood*; D002657:Child Development; D005312:Fetal Blood; D005647:Fucosyltransferases / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn / Q000097:blood* / Q000254:growth & development*; D007519:Isoantigens / Q000032:analysis* / Q000097:blood; D007983:Lewis Blood Group Antigens / Q000235:genetics* / Q000276:immunology; D010641:Phenotype
D007519:Isoantigens; D007983:Lewis Blood Group Antigens; D005647:Fucosyltransferases