[Cutaneous pyoderma gangrenosum with hepatosplenic localization and monoclonal gammapathy. A case report].
Pyoderma gangrenosum is an ulcerative disease of the skin. The histopathological lesions are nonspecific, characterized by a diffuse neutrophilic infiltrate in the dermis. Pyoderma gangrenosum is associated with inflammatory, digestive or articular disease, or acute or chronic hemotology disorders in 50% of the cases, more rarely with monoclonal gammapathy. A visceral localization of pyoderma gangrenosum is rare, simulating a systemic disease or an underlying neoplasia. We report a case of cutaneous pyoderma gangrenosum with splenic and hepatic localizatios associated with an IgG monoclonal gammapathy. We emphasize the efficacy of immunosuppressor treatment and the importance of long-term monitoring of these patients.
Service de Médecine Interne et de Maladies Tropicales, Hôpital Saint-André, 1, rue Jean-Burguet, 33075 Bordeaux Cedex. Sxdelbrel@free.fr
X
X
Delbrel
P
P
Germain
J
J
Fach
G
G
Etienne
C
C
Beylot
M
M
Parrens
A
A
De Mascarel
M
M
Le Bras
M
M
Longy-Boursier
D016903:Drug Monitoring; D005260:Female; D006801:Humans; D017098:IgA Deficiency / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008107:Liver Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008875:Middle Aged; D017511:Pyoderma Gangrenosum / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D012871:Skin Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D013158:Splenic Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014057:Tomography, X-Ray Computed
D007166:Immunosuppressive Agents