[The relationship between expression of extracellular matrix and clinical pathology of primary lung carcinoma].
OBJECTIVE
To study the relationship between expression of laminin (LN), fibronectin (FN), collagen IV (Col. IV) and clinical pathology of primary lung cancer.


METHODS
LSAB method was used to detect the expression of LN, FN and Col. IV in 184 cases of lung carcinoma.


RESULTS
Expression of LN and Col. IV in well and moderately differentiated pulmonary squamous cell carcinoma were both higher than that in poorly differentiated cases (P < 0.01), and marked difference was found between lymph node positive and negative cases (P < 0.05). Obvious difference in the expression of LN and Col. IV was found between the patient groups with squamous cell carcinoma who died within 1/2 year and those surviving more than 5 years (P < 0.01), as was the difference in expression of FN (P < 0.05). Obvious difference in the expression of FN and Col. IV was found between patients groups with adenocarcinoma who died within 1/2 year and those surviving more than 5 years (P < 0.05, 0.01).


CONCLUSIONS
The expression of LN and Col. IV correlated with histological grading and lymph node metastasis of pulmonary squamous cell carcinoma; LN, FN, Col. IV can also be regarded as a parameter for evaluating prognosis of pulmonary squamous cell carcinoma. The expression of FN and Col. IV can be regarded as a parameter for evaluating the prognosis of pulmonary adenocarcinoma.
Department of Pathology, Qingdao University Medical College, Qingdao, Shandong 266021.
F
F
Xiang
Z
Z
Niu
M
M
Yang
D000230:Adenocarcinoma / Q000737:chemistry / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology; D003094:Collagen / Q000032:analysis*; D005353:Fibronectins / Q000032:analysis*; D005500:Follow-Up Studies; D006801:Humans; D007797:Laminin / Q000032:analysis*; D008175:Lung Neoplasms / Q000737:chemistry* / Q000473:pathology; D008207:Lymphatic Metastasis; D011379:Prognosis
D005353:Fibronectins; D007797:Laminin; D003094:Collagen