A benign-looking subcutaneous metastasis from squamous cell cervical carcinoma: A case report and review of the literature.
A 30-year-old woman with a stage IIIB grade 3 squamous cell cervical carcinoma and pelvic lymph node metastases was treated with external beam radiotherapy and intracavitary brachytherapy. One month after the completion of the treatment, a rubbery, movable, and painless mass appeared in the lower third and outer aspect of her right thigh. The overlying epidermis was intact. The whole clinical picture and CT scan image indicated a benign tumor. Biopsy revealed a nonkeratinizing, grade 2-3, squamous cell carcinoma similar to the primary cervical tumor. She then received six cycles of chemotherapy (cis-platinum and 5-fluorouracil) with transient partial response. The patient died one year after the diagnosis of the disease. This is the 29th case of cutaneous metastasis from a cervical carcinoma, the seventh localized on the leg, but the first solitary one with a benign-looking appearance reported since 1855. The possible mechanism of this rare metastasis is debated and the literature is reviewed.
Department of Radiology - Radiotherapy and 2nd Obstetric - Gynecologic Clinic, University of Athens, Aretaeion Hospital, and Department of Pathology, Hellenic Airforce General and V.A. Hospital, Athens, Greece.
J. R.
JR
Kouvaris
G. A.
GA
Plataniotis
D. G.
DG
Floros
C. A.
CA
Sykiotis
S. J.
SJ
Trakadas
L. J.
LJ
Vlahos