Effect of furosemide on renal excretion of oxypurinol and purine bases.
To examine whether furosemide affects the plasma concentration and urinary excretion of purine bases and oxypurinol, we administered allopurinol (300 mg) orally to 6 healthy subjects and then administered furosemide (20 mg) intravenously 10 hours later. Furosemide (20 mg) decreased the urinary excretion of uric acid by 40% (P < .01), oxypurinol by 39% (P < .05), and xanthine by 43% (P < .05) and the fractional clearance of uric acid by 45% (P < .01) and oxypurinol by 34% (P < .05) when measured 1 to 2 hours after administration. Moreover, furosemide increased the plasma concentration of uric acid by 6% at 1.5 hours after administration. These results indicate that furosemide may decrease the urinary excretion of uric acid and oxypurinol by acting on their common renal transport pathway(s). In addition, it is suggested that the effect of furosemide on oxypurinol is clinically important, since the hypouricemic effect of allopurinol may become more potent as a result.
Third Department of Internal Medicine, Hyogo College of Medicine, Japan.
T
T
Yamamoto
Y
Y
Moriwaki
S
S
Takahashi
Z
Z
Tsutsumi
T
T
Hada
D000284:Administration, Oral; D000328:Adult; D000450:Aldosterone / Q000097:blood; D000493:Allopurinol / Q000008:administration & dosage / Q000494:pharmacology; D000804:Angiotensin II / Q000097:blood; D002712:Chlorides / Q000652:urine; D003404:Creatinine / Q000378:metabolism; D004232:Diuretics / Q000008:administration & dosage / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008875:Middle Aged; D010117:Oxypurinol / Q000097:blood / Q000652:urine*; D011188:Potassium / Q000652:urine; D011687:Purines / Q000097:blood / Q000378:metabolism / Q000652:urine*; D012964:Sodium / Q000652:urine; D014527:Uric Acid / Q000097:blood / Q000378:metabolism / Q000652:urine; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors
D002712:Chlorides; D004232:Diuretics; D011687:Purines; D000804:Angiotensin II; D014527:Uric Acid; D000450:Aldosterone; D000493:Allopurinol; D005665:Furosemide; D012964:Sodium; D003404:Creatinine; D014969:Xanthine Oxidase; D010117:Oxypurinol; D011188:Potassium