Is there a relationship between cognitive dysfunction and systemic inflammatory response after cardiopulmonary bypass?
BACKGROUND
The systemic inflammatory reaction (SIR) is assumed to be one of the factors that causes cerebral dysfunction after cardiopulmonary bypass (CPB). The aim of the present study was to evaluate the relationship between the SIR and postoperative cognitive performance at 5 days and 3 months.


METHODS
One hundred patients undergoing coronary artery bypass grafting were studied. Inflammatory markers and markers of coagulation and fibrinolysis were determined at several time points during and after the operation. Correlation analysis between maximum levels of the different markers and early and late performance was performed.


RESULTS
No overall association was found between the maximum levels of the inflammatory markers and early and late function.


CONCLUSIONS
Notwithstanding limitations of statistical power established markers of systemic inflammatory reaction showed no relationship with outcome at 5-day or 3-month follow-up in this subset of patients.
Oxford Heart Centre, John Radcliffe Hospital, Oxford, England. swestaby@ahf.org.uk
S
S
Westaby
K
K
Saatvedt
S
S
White
T
T
Katsumata
W
W
van Oeveren
P W
PW
Halligan
D000368:Aged; D002315:Cardiopulmonary Bypass; D003072:Cognition Disorders / Q000175:diagnosis / Q000276:immunology*; D001026:Coronary Artery Bypass; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D011183:Postoperative Complications / Q000175:diagnosis / Q000276:immunology*; D012307:Risk Factors; D018746:Systemic Inflammatory Response Syndrome / Q000175:diagnosis / Q000276:immunology
D018836:Inflammation Mediators