Serum IgG and IgE antibodies against mold-derived antigens in patients with symptoms of hypersensitivity.
BACKGROUND
Exposure to mold in water-damaged buildings has been suggested to be responsible for various health problems such as hypersensitivity and upper respiratory tract diseases. However, only little information is available on possible diagnostic tools for examining mold-associated health problems.


METHODS
We used recently developed immunofluorometric IgG and IgE assays (UniCAP) to examine serum IgG and IgE antibodies against mold-derived allergens from 70 mold-exposed individuals with (n = 55) or without (n = 15) symptoms of sensitization. Controls were healthy individuals (n = 31) without any history of such exposure.


RESULTS
The IgG titers exceeded the upper normal limits of control individuals (mean +/- 2 S.D.) in 35% of symptomatic men and in 25% of women. The IgG titers were usually higher in women than in men (P < 0.05) showing no significant association with the severity of symptoms. During follow-up of eight mold-exposed subjects for 9-12 months the IgG titers remained relatively constant. Elevated anti-mold IgEs were found in six (11%) of the exposed subjects who were all symptomatic.


CONCLUSIONS
Measurements of anti-mold IgGs may help to confirm exposure in patients with hypersensitivity symptoms and evidence of mold growth in living or working environment. Some exposed symptomatic patients present IgE-mediated responses. Combined measurements of IgGs and IgEs may prove to be of value in the comprehensive assessment and treatment of such patients.
Makkonen
K
K
Laboratory of the Central Hospital of Southern Ostrobothnia, FIN-60220, Seinäjoki, Finland.
Viitala
K I
KI
Parkkila
S
S
Niemelä
O
O
D000293:Adolescent; D000328:Adult; D000946:Antigens, Fungal / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005658:Fungi / Q000145:classification / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D006967:Hypersensitivity / Q000097:blood / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D008297:Male; D013045:Species Specificity
D000946:Antigens, Fungal; D001323:Autoantibodies; D007074:Immunoglobulin G; D007073:Immunoglobulin E