Angiotensin II type 2 receptors: signalling and pathophysiological role.
The signalling mechanisms and biological significance of the angiotensin II type 2 receptor have long been unknown. In recent years, studies, first in cell culture models but now increasingly also in vivo, have shed some light on the molecular events occurring after a stimulation of the receptor with its ligand as well as on its physiological effects and its significance for pathophysiological processes. There is increasing evidence that the angiotensin II type 2 receptor is involved in different pathophysiological processes, such as myocardial infarction, heart and kidney failure, and stroke.
Blume
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Institute of Pharmacology, University of Kiel, Germany.
Kaschina
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E
Unger
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T
D000818:Animals; D017209:Apoptosis; D001808:Blood Vessels / Q000503:physiopathology; D002454:Cell Differentiation; D006321:Heart / Q000503:physiopathology; D006333:Heart Failure / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008954:Models, Biological; D009203:Myocardial Infarction / Q000503:physiopathology; D009416:Nerve Regeneration; D009420:Nervous System / Q000503:physiopathology; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000502:physiology*; D051437:Renal Insufficiency / Q000503:physiopathology; D015398:Signal Transduction; D020521:Stroke / Q000503:physiopathology
D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin