[Primary gastric lymphomas. Clinico-pathological study and evaluation of prognostic factors in 65 cases treated surgically].
Based on the histological criteria proposed by the REAL and adopted by the WHO Classification, 30 cases of MALT type lymphoma, 18 cases of diffuse large B cell lymphoma (DLCL), and 17 cases of DLCLs, associated with a MALT type, were identified in a series of 65 surgically treated primary gastric lymphomas. The clinical records of the patients were analyzed retrospectively and the resected specimens were immunostained for bcl-2, p53 and Ki-67. Primary gastric DLBCLs, with or without a MALT type component, disclosed a higher stage of local extension, a more frequent nodal involvement and a significantly worse survival than pure MALT types. High p53 expression and high proliferation rate correlated with the presence of a large cell component and appeared useful for its identification in mixed forms. Low bcl-2 expression discriminated DLCL from DLCL/MALT. Tumor size, stage and Mib-1 index revealed a value in predicting prognosis.
Dipartimento di Scienze Cliniche e Biologiche, Università dell'Insubria, Varese.
B
B
Pozzi
A M
AM
Hotz
M
M
Feltri
M
M
Cornaggia
L
L
Campiotti
M
M
Bonato
G
G
Pinotti
C
C
Capella
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000032:analysis; D015703:Antigens, CD / Q000032:analysis; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor / Q000032:analysis; D003131:Combined Modality Therapy; D005260:Female; D005756:Gastritis / Q000150:complications / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D007633:Keratins / Q000032:analysis; D019394:Ki-67 Antigen / Q000032:analysis; D015993:Life Tables; D018442:Lymphoma, B-Cell, Marginal Zone / Q000737:chemistry / Q000401:mortality / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D016403:Lymphoma, Large B-Cell, Diffuse / Q000737:chemistry / Q000401:mortality / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis; D009367:Neoplasm Staging; D009687:Nuclear Proteins / Q000032:analysis; D010641:Phenotype; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D012189:Retrospective Studies; D013274:Stomach Neoplasms / Q000737:chemistry / Q000401:mortality / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
D000942:Antigens, Bacterial; D015703:Antigens, CD; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016159:Tumor Suppressor Protein p53; D007633:Keratins