The interaction of tributyllead with lysosomes from rat liver.
The interactions of tributyllead with lysosomes from rat liver have been studied. It results that the organometal compound induces a fast alkalinization in energized lysosomes. The interpretation is that the compound is a potent proton carrier. This function could explain the toxicity, in particular at neurological level of the compound.
Dipartimento Scienze Ambientali, Università di Venezia, Italy. bragadin@unive.it
M
M
Bragadin
D
D
Marton
S
S
Manente
A
A
Toninello
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D022781:Hepatocytes / Q000166:cytology* / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007476:Ionophores / Q000494:pharmacology; D008247:Lysosomes / Q000737:chemistry* / Q000187:drug effects / Q000378:metabolism; D018942:Macrolides; D009942:Organometallic Compounds / Q000737:chemistry* / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D006180:Proton-Translocating ATPases / Q000737:chemistry / Q000378:metabolism; D011522:Protons; D051381:Rats; D014634:Valinomycin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D007476:Ionophores; D018942:Macrolides; D009942:Organometallic Compounds; D011522:Protons; C113521:tributyllead chloride; C057620:bafilomycin A; D014634:Valinomycin; D006180:Proton-Translocating ATPases; D011188:Potassium