Identification of a silent pituitary somatotropic adenoma based on a paradoxic response of growth hormone on a thyrotropin-releasing hormone or gonadotropin-releasing hormone provocation test.
Preoperative endocrinologic identification and surgical removal of a silent somatotropic adenoma among patients with either amenorrhea or galactorrhea, or both, are beneficial for the restoration of menstruation and ovulation. Paradoxic rises of serum growth hormone in either a thyrotropin-releasing hormone or a gonadotropin-releasing hormone provocation test and high serum growth hormone levels were noted in the 3 patients with a silent somatotropic adenoma.
Matsuno
A
A
Department of Neurosurgery, Teikyo University Ichihara Hospital, Ichihara City, Chiba, Japan.
Ogino
Y
Y
Katayama
H
H
Osamura
R Y
RY
Nagashima
T
T
D000236:Adenoma / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D000328:Adult; D000568:Amenorrhea / Q000150:complications; D005260:Female; D005687:Galactorrhea / Q000150:complications; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D019382:Human Growth Hormone / Q000097:blood*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D010911:Pituitary Neoplasms / Q000097:blood / Q000150:complications / Q000175:diagnosis* / Q000601:surgery; D011388:Prolactin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage
D019382:Human Growth Hormone; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D007334:Insulin-Like Growth Factor I; D011388:Prolactin