The mood cycle hypothesis: possible involvement of steroid hormones in mood regulation by means of Na+, K+-ATPase inhibition.
The mood cycle hypothesis attempts to propose a model for mood regulation based on current data. The hypothesis contends that steroid hormones inhibit sodium-potassium adenosine triphosphatase (Na+, K+-ATPase; Na+ pump) in the hypothalamus, either directly or by converting into digitalis-like compounds. This inhibition stimulates beta-endorphin (beta-E) secretion, which is normally construed as elevated mood. In turn, beta-E inhibits steroid secretion, thus completing negative feedback loops. These loops are collectively termed the mood cycle.
Traub
N
N
Department of Physiology, The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Lichtstein
D
D
D000339:Affect / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D006801:Humans; D019964:Mood Disorders / Q000201:enzymology / Q000503:physiopathology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000502:physiology*; D013256:Steroids / Q000502:physiology*
D013256:Steroids; D000254:Sodium-Potassium-Exchanging ATPase