Research on the estimate of safety and toxicity of p-nitrophenol sodium with a physiologically based pharmacokinetics model.
The safety and toxicity of chemicals given first to animals and finally to humans are generally estimated with a method of safe coefficient, which is scientifically a way lack of grounds. To make a change of the old method, we designed a Physiologically-Based Pharmacokinetics Model for the estimate of safety and toxicity of chemicals. As an example, p-nitrophenol sodium (PNP-Na) is used in the research work. Studies of the PNP-Na pharmacokinetics in bodies of rat as well as humans are made, and possibilities of making use of the Model in the estimate of safety and toxicity of chemicals are discussed.
Gao
Q
Q
Department of Hygiene and Preventive Medicine, Faculty of Medicine, University of Tokyo.
Kurihara
N
N
Yanagisawa
H
H
Wada
O
O
D000818:Animals; D006801:Humans; D008954:Models, Biological; D009596:Nitrophenols / Q000493:pharmacokinetics*; D051381:Rats; D014018:Tissue Distribution
D009596:Nitrophenols; C024836:4-nitrophenol