Expression of the voltage-dependent chloride channel ClC-3 in human nasal tissue.
In the present study, ClC-3, one of the voltage-dependent chloride channels, was identified in human nasal tissue. In situ hybridization and immunohistochemical investigations demonstrated the localization of ClC-3 in the serous acini and ductal portions of submucosal nasal glands, which are the primary source of nasal secretion. Our data suggest that this channel contributes to nasal secretion via chloride transport. Its dysfunction might lead to abnormal nasal secretion in such pathological states as sinusitis.
Department of Otolaryngology, Tohoku University School of Medicine, Sendai, Japan. oshima@orl.med.tohoku.ac.jp
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T
Oshima
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K
Ikeda
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M
Furukawa
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H
Suzuki
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T
Takasaka
D018118:Chloride Channels / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D009297:Nasal Mucosa / Q000737:chemistry* / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D018118:Chloride Channels