Focal adhesions: structure and dynamics.
Interactions of cells with the extracellular matrix are essential for the control of tissue remodelling, cell migration, and embryogenesis. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where transmembrane adhesion receptors provide a structural link between the actin cytoskeleton and the extracellular matrix components. Numerous structural and regulatory proteins assemble at the cytoplasmic face of focal adhesions in a Rho-dependent fashion.
Petit
V
V
Subcellular structure and cellular dynamics, UMR 144, CNRS-institut Curie, Paris, France.
Thiery
J P
JP
D002448:Cell Adhesion / Q000502:physiology*; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D022001:Focal Adhesions / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D008954:Models, Biological; D015398:Signal Transduction / Q000502:physiology; D020741:rho GTP-Binding Proteins / Q000378:metabolism
D003598:Cytoskeletal Proteins; D016023:Integrins; D008565:Membrane Proteins; D020741:rho GTP-Binding Proteins