[Amplification of transcription of separate mitochondrial genes in human and monkey B-cell non-Hodgkin's lymphoma].
Mitochondrial genes that are overexpressed in human and monkey B-cell non-Hodgkin lymphomas (B-NHLs) were sought via subtraction hybridization, cloning, and differential screening of the resulting cDNA libraries. The cDNAs of mitochondrial genes made an appreciable proportion of all lymphoma-specific cDNAs. Lymphomogenesis was associated with overexpression of a mitochondrial gene set which varied with lymphoma type and always included NADHIV. A possible association between overexpression of certain mitochondrial genes and cell malignant transformation is discussed.
Nikolaev
A I
AI
Martynenko
A V
AV
Kalmyrzaev
B B
BB
Inozemtseva
L I
LI
Dubovaia
V I
VI
Hunsmann
G
G
Bodemer
V
V
Tarandul
V Z
VZ
D000818:Animals; D003001:Cloning, Molecular; D018076:DNA, Complementary; D000882:Haplorhini; D006801:Humans; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008928:Mitochondria / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D013382:Subtraction Technique; D014158:Transcription, Genetic
D018076:DNA, Complementary