Treatment in typical and atypical rolandic epilepsy.
Benign rolandic epilepsy is the most common epilepsy of childhood. Regarding seizure control typical and atypical rolandic epilepsies have a reasonable prognosis. In a recent prospective study STM was shown to control seizures in BECTS and STM is regarded as first line drug for this epilepsy in countries having access to this drug. Otherwise, CBZ is used most often and very effectively in BECTS. However, CBZ has the disadvantage to worsen clinical and EEG features up to the precipitation of CSWS in few patients. Epileptic seizures are often not the main problem in atypical rolandic epilepsies like CSWS or LKS and the amelioration of cognitive dysfunction by epileptic discharge is the prominent aim of an AED therapy. Steroids seem the have the best efficacy in these cases.
Dept Pediatric Neurology, Children's Hospital, University of Heidelberg, Im Neuenheimer Feld 153, Heidelberg, Germany. dietz_rating@med.uni-heidelberg.de
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D000293:Adolescent; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000927:Anticonvulsants / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001569:Benzodiazepines; D002648:Child; D000075202:Contraindications; D004305:Dose-Response Relationship, Drug; D019305:Epilepsy, Rolandic / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage*; D018887:Landau-Kleffner Syndrome / Q000188:drug therapy; D011612:Psychosurgery; D016032:Randomized Controlled Trials as Topic; D012075:Remission, Spontaneous; D012640:Seizures / Q000188:drug therapy; D013577:Syndrome; D013843:Thiazines / Q000008:administration & dosage* / Q000009:adverse effects; D000096926:Benzenesulfonamides
D014151:Anti-Anxiety Agents; D000927:Anticonvulsants; D001569:Benzodiazepines; D005938:Glucocorticoids; D016756:Immunoglobulins, Intravenous; D013843:Thiazines; C084593:sulthiame; D000096926:Benzenesulfonamides