Pimarane cyclooxygenase 2 (COX-2) inhibitor and its structure-activity relationship.
The structure-activity relationship and molecular modelings of a novel pimarane COX-2 inhibitor are reported. Particularly, a series of linker extended analogues designed on the basis of these studies exhibited significantly enhanced COX-2 inhibitory activities and selectivities.
Suh
Y G
YG
College of Pharmacy, Seoul National University, South Korea. ygsuh@plaza.snu.ac.kr
Kim
Y H
YH
Park
M H
MH
Choi
Y H
YH
Lee
H K
HK
Moon
J Y
JY
Min
K H
KH
Shin
D Y
DY
Jung
J K
JK
Park
O H
OH
Jeon
R O
RO
Park
H S
HS
Kang
S A
SA
D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D004224:Diterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D011451:Prostaglandin-Endoperoxide Synthases; D013329:Structure-Activity Relationship
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D004224:Diterpenes; D007527:Isoenzymes; C099958:acanthoic acid; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases