Randomized trial of cefotiam prophylaxis in the prevention of postoperative infectious morbidity after elective cesarean section.
A prospective, randomized study was performed in order to evaluate the effect of cefotiam in the prevention of postoperative infectious morbidity in patients undergoing low-risk elective cesarean section. A total of 146 patients were randomly assigned to receive either intraoperative single-shot prophylaxis with 2 g cefotiam (study group, n =76) or no prophylaxis (control group, n=70). Due to a higher rate of urinary tract infections, the incidence of infectious morbidity after cefotiam prophylaxis was higher in the study group than in the control group (16% vs. 9%, P=0.1). Postoperative infectious morbidity following low-risk elective cesarean section cannot be reduced by intraoperative cefotiam prophylaxis.
Kolben
M
M
Frauenklinik und Poliklinik der Technischen Universität München, Klinikum rechts der Isar, Germany. m.kolben@lrz.tum.de
Mandoki
E
E
Ulm
K
K
Freitag
K
K
D000328:Adult; D019072:Antibiotic Prophylaxis; D001424:Bacterial Infections / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D015310:Cefotiam / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002585:Cesarean Section; D017558:Elective Surgical Procedures; D005260:Female; D006801:Humans; D008875:Middle Aged; D009017:Morbidity; D011183:Postoperative Complications / Q000188:drug therapy / Q000453:epidemiology / Q000517:prevention & control*; D011446:Prospective Studies; D012307:Risk Factors
D002511:Cephalosporins; D015310:Cefotiam