Intracervical fibrin sealants: a potential treatment for early preterm premature rupture of the membranes.
OBJECTIVE
We report our experience with a transvaginally applied intracervical fibrin sealant at <24 weeks' gestation.


METHODS
This is an observational study of a referred patient population, with preterm premature rupture of the membranes at <24 weeks' gestation.


RESULTS
Twelve women consented to our protocol. The mean gestational age at preterm premature rupture of membranes was 19 weeks 4 days (range, 13-23 weeks); the mean gestational age at treatment was 20 weeks 5 days (range, 17-23 weeks). All women had a diminution in the amount of amniotic fluid leakage with an increase in amniotic fluid index. Among the 12 pregnancies (13 fetuses), there were 7 surviving neonates. Two women had apparent "resealing" of the membranes.


CONCLUSIONS
Fibrin sealants in midtrimester rupture of the membranes may lead to improved outcomes and now warrant formal evaluation.
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Christiana Care Health Services, Newark, Delaware 19718, USA.
A C
AC
Sciscione
J S
JS
Manley
M
M
Pollock
B
B
Maas
P A
PA
Shlossman
W
W
Mulla
M
M
Lankiewicz
G H
GH
Colmorgen
D000328:Adult; D000653:Amniotic Fluid / Q000000981:diagnostic imaging / Q000502:physiology; D001510:Bed Rest; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications / Q000628:therapy*; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000627:therapeutic use*; D005865:Gestational Age; D006801:Humans; D016104:Oligohydramnios / Q000150:complications; D010865:Pilot Projects; D011247:Pregnancy; D011256:Pregnancy Outcome; D014463:Ultrasonography
D015718:Fibrin Tissue Adhesive