Genetic analysis of the Utah population: a comparison of STR and VNTR loci.
Genetic data are reported for nine short tandem repeat (STR) loci (D3S1358, vWA, FGA, D8S1179, D21S11, D18S51, D5S818, D13S317, and D7S820) and six variable number of tandem repeat (VNTR) loci (D2S44, D10S28, D4S139, D1S7, D5S110, and D17S79) in samples of Utah African Americans, European Americans, and Hispanics. Little evidence of departures from Hardy-Weinberg equilibrium or gametic equilibrium was found in these populations. Because of their relatively higher mutation rates, the VNTR loci exhibited higher average heterozygosity and lower FST levels than did the STR loci. Genetic distance analysis showed congruence between the two types of systems, and a genetic distance analysis of the STR data showed that the three Utah populations are genetically similar to the same ethnic groups in other parts of the United States. In addition, this analysis showed that the African American population is the most genetically divergent, with greater similarity between the Hispanic and European American populations. This analysis demonstrates a high degree of consistency for population designations commonly used in forensic analysis.
Eccles Institute of Human Genetics, University of Utah School of Medicine, Salt Lake City 84112, USA.
L B
LB
Jorde
P A
PA
Shortsleeve
J W
JW
Henry
R T
RT
Vanburen
L E
LE
Hutchinson
T M
TM
Rigley
D019143:Evolution, Molecular; D005554:Forensic Medicine; D006801:Humans; D018598:Minisatellite Repeats; D008957:Models, Genetic; D011110:Polymorphism, Genetic / Q000235:genetics*; D044469:Racial Groups / Q000235:genetics*; D015203:Reproducibility of Results; D020080:Tandem Repeat Sequences; D014589:Utah