[Specific antigenic preparations as inducers of blood leukocyte respiratory burst in chemiluminescent analysis].
Functional activity of blood leukocytes of normal subjects and patients with herpesvirus infection was studied by the chemiluminescent method in vitro with specific antigenic preparations (tick-borne encephalitis vaccine, ADPT vaccine, and herpetic vaccine). Functional response of blood leukocytes to vaccine preparations is specific and depends on the antigen and metabolic status of cells of recipients. The range of chemiluminescent response of blood leukocytes is wide: no changes in tick-borne encephalitis vaccine, weak response to herpetic vaccine, and pronounced changes in functional activity in response to ADPT vaccine. Testing with different doses of specific inducers helps additionally evaluate the metabolic reserve of blood leukocytes. A pronounced response of leukocytes to specific antigenic preparations in vitro (e.g. to ADPT vaccine) prompts development of methods for predicting the reaction of nonspecific reactivity system to vaccination.
Dorokhina
N A
NA
Savchenko
A A
AA
Chesnokov
A B
AB
Polonskaia
Zh G
ZhG
Ol'khovskiĭ
I A
IA
Shakina
N A
NA
D000956:Antigens, Viral; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000276:immunology; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology; D006561:Herpes Simplex / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000276:immunology / Q000378:metabolism*; D008163:Luminescent Measurements; D018375:Neutrophil Activation; D012008:Recurrence; D016897:Respiratory Burst / Q000276:immunology; D018139:Simplexvirus / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology
D000956:Antigens, Viral; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D014765:Viral Vaccines