Cellular response to bioactive lipid peroxidation products.
Reactive aldehydes, such as 4-hydroxy-2-nonenal, have been implicated as inducers in generating intracellular reactive oxygen species and activation of stress signaling pathways, that integrate with other signaling pathways to control cellular responses to the extracellular stimuli. Here, I briefly summarize a novel signaling pathway in cellular response, in which aldehyde-stimulated detoxification response is mediated by cyclooxygenase metabolites. These findings argue that lipid mediators could induce a cellular process that represents a cellular defense program against toxic compounds.
Laboratory of Food and Biodynamics, Graduate School of Bioagricultural Sciences, Nagoya University, Japan. uchidak@agr.nagoya-u.ac.jp
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D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D051546:Cyclooxygenase 2; D003517:Cyclopentanes / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D015227:Lipid Peroxidation; D008565:Membrane Proteins; D018384:Oxidative Stress; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction
D000447:Aldehydes; D003517:Cyclopentanes; D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D005982:Glutathione Transferase; C027576:4-hydroxy-2-nonenal; C013905:cyclopentenone