Total body irradiation-based regimen in the conditioning of patients submitted to haploidentical stem cell transplantation.
OBJECTIVE
To evaluate the efficacy and toxicity of a highly immuno- and myelo-suppressive conditioning regimen followed by the infusion of large numbers of T-cell-depleted mismatched haematopoietic stem cells in 43 high-risk acute leukaemia patients.


RESULTS
A high rate of engraftment (95%) and no graft-versus-host disease (GvHD) were observed. The 4-year probability of event-free survival was 0.25+/-0.09 for acute myeloid leukaemia and 0.17+/-0.07 for acute lymphoid leukaemia patients.


CONCLUSIONS
This study shows that the main obstacles limiting the use of mismatched transplants, i.e. GvHD and rejection, were overcome.
Institute of Radiotherapy Oncology, General Hospital and University, Perugia, Italy.
C
C
Aristei
P
P
Latini
A
A
Terenzi
R
R
Felicini
F
F
Aversa
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006085:Graft Survival; D006087:Graft vs Host Reaction; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D007945:Leukemia, Lymphoid / Q000401:mortality / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000401:mortality / Q000628:therapy*; D008212:Lymphocyte Depletion; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D019172:Transplantation Conditioning; D014916:Whole-Body Irradiation