[Chronic and slow neuroinfections. Current status of problem].
Some causes and conditions of chronic and slow neuroinfections were reviewed: brain immunological "priveledge"; congenital immunodeficiencies including clinically latent; immunomodulation induced by microorganisms due to infection of immune cells, inactivation of cytokines making difficulties to antibodies; disorders of genetic control of immune reaction; immunopathologic processes are of great importance for the agents persistence including autoimmunity. Microorganisms can locate in the neurons, glyocytes, endothelium. Neuroinfections chronic course depends on the agents properties and peculiarities of nervous system reactivity.
St. Petersburg Medical Pediatric Academy, 194100, St. Petersburg.
P V
PV
Antonov
V A
VA
Tsinzerling
D001424:Bacterial Infections; D002908:Chronic Disease; D006801:Humans; D009422:Nervous System Diseases