Role of angiotensin and its inhibition in hypertension, ischemic heart disease, and heart failure.
This is a personal historical account relating the events that led to the first application of angiotensin inhibition (either by ACE inhibitors or by angiotensin receptor blockade) to the investigation of the pathogenesis and treatment of hypertension, ischemic heart disease, and heart failure. Included are animal experiments, clinical observations, and the earliest clinical experimental studies that helped define some of the detrimental effects of angiotensin II and the beneficial hemodynamic results of its inhibition, which have been subsequently corroborated and amplified by large randomized outcome trials.
Gavras
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Hypertension and Atherosclerosis Section of the Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA. hgavras@bu.edu
Brunner
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D000328:Adult; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000809:Angiotensins / Q000037:antagonists & inhibitors / Q000502:physiology*; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D002216:Captopril / Q000008:administration & dosage / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003326:Coronary Circulation / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy / Q000209:etiology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000209:etiology*; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects; D012504:Saralasin / Q000008:administration & dosage / Q000627:therapeutic use; D013722:Teprotide / Q000008:administration & dosage / Q000627:therapeutic use
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000809:Angiotensins; D000959:Antihypertensive Agents; D002216:Captopril; D013722:Teprotide; D012083:Renin; D012504:Saralasin