[Immunocorrecting and protective effect of proteolytic enzymes on antibody formation in mice in staphylococcal infection and antibiotic treatment].
The impact of proteolytic enzymes on the humoral immune response, survival rate and mean survival time of mice, infected with S. aureus culture and receiving antibiotics was studied. Infection with staphylococcal suppressed the formation of antibodies to sheep red blood cells. Ampicillin made this immunosuppression even more pronounced, while gentamicin produced practically no effect on the degree of immunosuppression in the infected animals. Proteolytic enzymes terrilytin and terridecase exhibited immunocorrecting properties when used in combination with antibiotics. Terridecase, the immobilized form of the enzyme proved to have the highest activity. In experimental generalized staphylococcal infection all preparations under study produced a protective effect. The maximum effect was noted after the use of ampicillin in combination with terridecase.
State Medical University, Kursk, State Medical University, Moscow, Russia.
I G
IG
Khmelevskaia
L V
LV
Koval'chuk
D000667:Ampicillin / Q000627:therapeutic use*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D004800:Enzymes, Immobilized / Q000627:therapeutic use*; D005839:Gentamicins / Q000627:therapeutic use*; D006868:Hydrolysis; D012756:Sheep; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology
D000907:Antibodies, Bacterial; D004800:Enzymes, Immobilized; D005839:Gentamicins; D000667:Ampicillin