Therapeutic response and long-term follow-up in a systemic lupus erythematosus patient presenting with Kikuchi's disease.
Kikuchi's disease (KD) can occur in association with systemic lupus erythematosus (SLE). The treatment of concomitant diseases, however, is unclear. We describe a case of a 45-y-old man who presented with generalized histiocytic necrotizing lymphadenitis, fever, malaise and weight loss. Ten months later he also developed arthritis, serositis, anemia, leukopenia and lymphopenia. ANA, anti-Smith, anti-snRNP and anti-Ro antibodies were positive. He responded rapidly and favorably to mid-dose prednisone. Hydroxychloroquine, added 5 months later, allowed tapering down and discontinuation of prednisone treatment. He has remained in complete remission for 5 years.
Department of Internal Medicine, Universidad Central del Caribe School of Medicine, Bayamón, Puerto Rico 00960-6032, USA.
L M
LM
Vilá
A M
AM
Mayor
I E
IE
Silvestrini
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D020042:Histiocytic Necrotizing Lymphadenitis / Q000150:complications*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D011241:Prednisone