Three ways to make a vesicle.
Cargo molecules have to be included in carrier vesicles of different forms and sizes to be transported between organelles. During this process, a limited set of proteins, including the coat proteins COPI, COPII and clathrin, carries out a programmed set of sequential interactions that lead to the budding of vesicles. A general model to explain the formation of coated vesicles is starting to emerge but the picture is more complex than we had imagined.
Kirchhausen
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Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA. kirchhausen@crystal.harvard.edu
D000818:Animals; D022181:COP-Coated Vesicles / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D002966:Clathrin / Q000737:chemistry / Q000502:physiology*; D020755:Coat Protein Complex I / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D022161:Transport Vesicles / Q000502:physiology*
D002966:Clathrin; D020755:Coat Protein Complex I