Modafinil does not affect serotonin efflux from rat frontal cortex synaptosomes: comparison with known serotonergic drugs.
Modafinil did not affect spontaneous and K(+)-evoked [3H]5-HT efflux from cortical synaptosomes while it increased K(+)-evoked tritium efflux from cortical slices, an action that became stronger in the presence of paroxetine. In contrast, DL-fenfluramine and fluoxetine were able to enhance spontaneous and/or K(+)-evoked tritium efflux from synaptosomes and slices. These results suggest that modafinil does not affect 5-HT transmission from cortical synaptosomes and that its 5-HT releasing action is different from that of DL-fenfluramine and fluoxetine.
Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, Ferrara, Italy.
L
L
Ferraro
S
S
Tanganelli
K
K
Fuxe
B W
BW
Bebe
M C
MC
Tomasini
F A
FA
Rambert
T
T
Antonelli
D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D005277:Fenfluramine / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D005625:Frontal Lobe / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D000077408:Modafinil; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017374:Paroxetine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000493:pharmacokinetics*; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D012890:Sleep / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism; D014316:Tritium
D001559:Benzhydryl Compounds; D005277:Fenfluramine; D005473:Fluoxetine; D000077408:Modafinil; D018696:Neuroprotective Agents; D017374:Paroxetine; D011188:Potassium; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors; D014316:Tritium