Effect of leaf essential oil from Piper solmsianum C.DC. in mice behaviour.
The essential oil from Piper solmsianum leaves and its major compound (sarisan) were tested to verify their influences upon mice behaviour. The essential oil was obtained by hydrodistillation in a modified Clevenger extractor and analysed by GC/ MS. This analysis revealed in the oil the presence of monoterpenes, sesquiterpenes and of arylpropanoids. The compound sarisan, a myristicin analogue, was isolated from the oil to perform the pharmacological tests. Emulsions of the oil and of sarisan (5.0 and 10.0% v/v) were used in the tests. Pentobarbital (30 mg/ kg s.c.) or diazepam (2.5 mg/ kg s.c.) were tested as standard drugs to verify depressant or anxiolytic effects, respectively. Both essential oil and sarisan showed to have exciting and depressant effects in the tested animals.
Moreira
D L
DL
Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro, 21941-590 Rio de Janeiro, RJ, Brazil. moreiradl@nppn.ufrj.br
Souza
P O
PO
Kaplan
M A
MA
Pereira
N A
NA
Cardoso
G L
GL
Guimarães
E F
EF
D017109:Akathisia, Drug-Induced / Q000503:physiopathology; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000139:chemically induced; D003975:Diazepam / Q000494:pharmacology; D004148:Dioxolanes / Q000494:pharmacology; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D009822:Oils, Volatile / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology; D018515:Plant Leaves; D010938:Plant Oils / Q000494:pharmacology*
D000935:Antifungal Agents; D004148:Dioxolanes; D006993:Hypnotics and Sedatives; D009822:Oils, Volatile; D010938:Plant Oils; C056048:sarisan; D010424:Pentobarbital; D003975:Diazepam