Testicular choriocarcinoma metastatic to the skin: an additional case and literature review.
Choriocarcinoma, a malignancy of trophoblastic cells, is characterized by the secretion of human chorionic gonadotropin (hCG). Choriocarcinoma primarily arises from the fetal (placental) trophoblasts in the setting of a molar pregnancy. Nongestational choriocarcinoma from the ovary or testis is much rarer. Testicular choriocarcinoma is a malignant tumor with great propensity for distant metastasis. The primary sites of metastasis are the lungs, liver, and brain. Skin metastasis is very rare but portends a grave prognosis when diagnosed. We present the case of a 24-year-old white male with a testicular mixed germ-cell tumor with skin metastases of choriocarcinoma.
University of California at Irvine, USA.
L L
LL
Tinkle
B S
BS
Graham
T J
TJ
Spillane
R J
RJ
Barr
D000328:Adult; D002822:Choriocarcinoma / Q000556:secondary*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000556:secondary*; D013736:Testicular Neoplasms / Q000473:pathology*