[Pheochromocytoma in Africa: rarity, gravity and ectopy].
Pheochromocytoma is one of the main curable etiologies of high blood pressure, although its diagnosis and therapeutic management can be problematical: an incorrect diagnosis or inappropriate treatment may lead to fatal complications. This disease was exceptionally uncommon in the 1950s, and 30 years later about 30 cases had been reported; however, since 1981 there has been a progressive increase in the incidence of pheochromocytoma (48 documented cases in Africa). In Africa, this disease has two particular characteristics: the gravity of the clinical symptoms, mainly due to the physiological and pharmacological effects of catecholamines which as a result of this disease are stored and liberated at very high rates; and the ectopic site in a number of cases. To facilitate the diagnosis of pheochromocytoma improved clinical investigation is therefore advocated, but the necessary medical equipment is not always available in Africa. On this continent, the ectopic factor confirms the observations made in the early 1980s, and should be taken into consideration in the diagnosis and management of this disease.
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Centre Marc-Sankale, service de médecine interne, clinique médicale II, BP 5062, Dakar-Fann, Sénégal.
D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D000328:Adult; D000349:Africa / Q000453:epidemiology; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D015994:Incidence; D008297:Male; D010673:Pheochromocytoma / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology; D012307:Risk Factors; D012720:Severity of Illness Index