A comparison of the respiratory effects of high concentrations of halothane and sevoflurane.
We studied the respiratory effects of the administration of either 5% halothane or 8% sevoflurane in 70% nitrous oxide (N2O) for 5 min in 21 boys aged 1-5 years. A similar degree of ventilatory depression was noted with both agents. Minute volume fell by approximately 50% as a result of a reduction in tidal volume despite an increase in respiratory rate.
Walpole
R
R
Department of Anaesthesia, Royal Hospital for Sick Children, Sciennes Road, Edinburgh EH9 1LF, UK.
Olday
J
J
Haetzman
M
M
Drummond
G B
GB
Doyle
E
E
D000767:Anesthesia, Epidural; D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D018685:Anesthetics, Inhalation / Q000009:adverse effects*; D002675:Child, Preschool; D003864:Depression, Chemical; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D008297:Male; D008738:Methyl Ethers / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane; D006221:Halothane