[A case report. Hypotensive reaction caused by albumin infusion].
Hypotensive reactions during surgical procedures cause diagnostic problems in establishing whether the hypotension is due to blood loss or pharmaceuticals or other causes. A case of hypotension probably due to an albumin infusion is described. Bradykinin effects are probably the cause of many hypotensive reactions. Angiotensin-converting enzyme (ACE) inhibitors reduce degradation of bradykinin and thus increase the risk of hypotensive reactions. When possible, doctors should consider withholding ACE inhibitors 24 hours before surgical procedures likely to require albumin transfusions.
Eriksson
M
M
Anestesi- och intensivvårdskliniken, Akademiska sjukhuset, Uppsala.
Nilsson
B
B
Modig
J
J
Acosta
R
R
Johansson
B
B
Larsson
A
A
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects; D016913:Blood Component Transfusion / Q000009:adverse effects*; D001920:Bradykinin / Q000378:metabolism; D005260:Female; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000209:etiology*; D007263:Infusions, Parenteral; D007431:Intraoperative Complications / Q000209:etiology*; D016462:Mammaplasty / Q000379:methods; D008408:Mastectomy; D008875:Middle Aged; D011229:Preanesthetic Medication; D012709:Serum Albumin / Q000008:administration & dosage / Q000009:adverse effects*; D013524:Surgical Flaps; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000009:adverse effects
D000806:Angiotensin-Converting Enzyme Inhibitors; D012709:Serum Albumin; D014665:Vasodilator Agents; D001920:Bradykinin