Immunity and protection against Brucella abortus.
Brucella abortus is an intracellular pathogen that causes disease in cattle and in humans. The response against B. abortus involves the whole gamut of the immune system, from innate to adaptive immunity resulting from stimulation of antigen-presenting cells, NK cells, CD4(+) and CD8(+) T cells, and B cells.
Division of Hematology, Office of Blood and Blood Research, Center for Biologics Research and Review, Food and Drug Administration, 1401 Woodmont, Rockville Pike, MD 20852, USA. golding@cber.fda.gov
B
B
Golding
D E
DE
Scott
O
O
Scharf
L Y
LY
Huang
M
M
Zaitseva
C
C
Lapham
N
N
Eller
H
H
Golding
D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells; D001402:B-Lymphocytes; D002003:Brucella abortus / Q000276:immunology*; D002006:Brucellosis / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007694:Killer Cells, Natural; D013601:T-Lymphocytes