Growth factor-dependent signaling and cell cycle progression.
There are three central ideas contained within this review. Firstly, growth factor-stimulated signaling is not restricted to a 30-60 min window, but occurs at a much later time as well. Secondly, the second wave of signaling overlaps temporally with the cell cycle program and may be directly responsible for engaging it. Thirdly, the G1 to S interval appears to encompass two distinct phases of the cell cycle, during which the coordinated activation of distinct sets of signaling enzymes drives cell cycle progression. Each of these concepts is likely to initiate new investigation and hence provide additional insight into the fundamental question of how growth factors drive cell proliferation.
Schepens Eye Research Institute, Harvard Medical School, Department of Ophthalmology, 20 Staniford St, Boston, MA 02114, USA.
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Kazlauskas
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D016193:G1 Phase / Q000187:drug effects; D006133:Growth Substances / Q000494:pharmacology*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D008934:Mitogens / Q000494:pharmacology; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D010766:Phosphorylation; D016196:S Phase / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects*; D013997:Time Factors
D006133:Growth Substances; D008934:Mitogens; D019869:Phosphatidylinositol 3-Kinases; D020928:Mitogen-Activated Protein Kinases