Electrophysiologic effects and efficacy of intravenous propafenone in terminating atrioventricular reentrant tachycardia in children.
In pediatric patients with atrioventricular reentrant tachycardia, intravenous propafenone exhibits its electrophysiologic effects in a dose-dependent manner by slowing or blocking retrograde conduction at the accessory connection. The high drug efficacy (81%) in terminating tachycardia is not dependent on patient age or retrograde conduction properties of the accessory connection.
Hessling
G
G
Division of Pediatric Cardiology, Children's Hospital, University of Heidelberg, Germany. GabrieleHesslingmed.uni-Heidelberg.de
Brockmeier
K
K
Ruediger
H J
HJ
Ulmer
H E
HE
D000293:Adolescent; D000367:Age Factors; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D022062:Electrophysiologic Techniques, Cardiac; D005260:Female; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D016014:Linear Models; D008297:Male; D011405:Propafenone / Q000008:administration & dosage*; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000188:drug therapy* / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D011405:Propafenone