KF19418, a new compound for hair growth promotion in vitro and in vivo mouse models.
KF19418, a newly synthesized compound, stimulated proliferation of cultured hair bulb cells from new born mice in concentration-dependent manner in the range under 10 microM. In the culture system of whole skin pieces from 4-week-old mice which we earlier established, KF19418 promoted hair follicle elongation as in the case of minoxidil. After topical application for 2 weeks of KF19418 or minoxidil to dorsal skin of hair-clipped mouse alopecia model, KF19418 at 1% suspension accelerated hair regrowth at a rate comparable to 1% minoxidil solution. Thus, it was shown that KF19418 directly stimulated hair follicle in vitro and had hair growth promoting activities in vivo.
Kyowa Hakko Kogyo Co., Ltd., Tokyo Research Laboratories, Tokyo, Japan. akio.shirai@kyowa.co.jp
A
A
Shirai
J
J
Ikeda
S
S
Kawashima
T
T
Tamaoki
T
T
Kamiya
D000505:Alopecia / Q000188:drug therapy* / Q000473:pathology; D000818:Animals; D002478:Cells, Cultured; D046508:Culture Techniques; D003879:Dermatologic Agents / Q000494:pharmacology*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006197:Hair / Q000187:drug effects* / Q000254:growth & development*; D018859:Hair Follicle / Q000187:drug effects / Q000254:growth & development; D006575:Heterocyclic Compounds, 3-Ring / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008914:Minoxidil / Q000494:pharmacology
D003879:Dermatologic Agents; D006575:Heterocyclic Compounds, 3-Ring; C429325:KF19418; D008914:Minoxidil