From Bittner to Barr: a viral, diet and hormone breast cancer aetiology hypothesis.
It is hypothesized that the human homologue of the mouse mammary tumour virus (HHMMTV) and other viruses, such as human papillomavirus (HPV) and Epstein-Barr virus (EBV), act as cofactors with diet, oestrogens and other hormones in the initiation and promotion of some types of breast cancer in genetically susceptible women. It is further hypothesized that diet influences the risk of breast cancer, through its influence on oestrogen metabolism and that of other hormones, in combination with genetic and infectious agents.
Center for Public Health, School of Health Services Management, University of New South Wales, Sydney, New South Wales, Australia. James.Lawson@unsw.edu.au
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Lawson
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Rawlinson
D001943:Breast Neoplasms / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D004032:Diet / Q000009:adverse effects*; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D004967:Estrogens / Q000009:adverse effects*; D005260:Female; D006801:Humans; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications*; D012307:Risk Factors; D014412:Tumor Virus Infections / Q000150:complications*
D004967:Estrogens