Mechanisms of autoimmune liver disease.
Several lines of evidence suggest that autoimmune hepatitis and primary biliary cirrhosis are autoimmune diseases. This article discusses both the immunologic mechanisms of liver injury and the mechanisms of cell injury mediated by lymphocytes. This article also reviews the proposed immunopathogenesis of autoimmune hepatitis and primary biliary cirrhosis.
Division of Digestive Diseases, Department of Internal Medicine, Ohio State University Health Science Center, Columbus, Ohio.
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Mabee
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Thiele
D017209:Apoptosis / Q000502:physiology; D019693:Hepatitis, Autoimmune / Q000276:immunology*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000276:immunology; D008214:Lymphocytes / Q000502:physiology; D011768:Pyruvate Dehydrogenase Complex / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology
D011768:Pyruvate Dehydrogenase Complex