Spectrophotometric and HPLC determination of fleroxacin in tablets.
The paper describes and compares spectrophotometric and HPLC determination of fleroxacin in commercial tablets. The optimum conditions for spectrophotometric assay were found to be at pH < 3.5 (0.1 M HCl) at a wave length of 286 nm. HPLC analysis was carried out on a Beckman ODS 5 microns column in a pH 3 phosphoric acid solution (detector wave length 254 nm).
Institute of Analytical, Inorganic and Physical Chemistry, Faculty of Pharmacy, University of Belgrade, Yugoslavia.
L
L
Milovanović
V
V
Kapetanović
G
G
Popović
Z
Z
Dugumović
D
D
Miljević
M
M
Aleksić
D000890:Anti-Infective Agents / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D016576:Fleroxacin / Q000032:analysis*; D007202:Indicators and Reagents; D012015:Reference Standards; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000890:Anti-Infective Agents; D007202:Indicators and Reagents; D012996:Solutions; D013607:Tablets; D016576:Fleroxacin