[Causes of para-allergy to tuberculin].
Experiments on 56 rabbits infected with microorganisms of the genera Mycobacterium, Nocardia and Rhodococcus revealed that in response to the action of different antigens used T and B systems of immunity induced synthesis of antibodies reactive with nonspecific antigens (mycobacterial antigens, tuberculin). In some cases the statistically significant correlation between the dynamics of blast transformation and the specific lysis of lymphocytes in animals with Nocardia and Rhodococcus infections (in comparison with the controls) was determined when P.P.D. tuberculin was used as specific antigen. In the rabbits sera infected by Nocardia and Rhodococcus complement-fixation and hemagglutination antibodies to mycobacterial antigens were detected. These rabbits also exhibited skin reaction to P.P.D. tuberculin. The presence of common group-specific antigens in Nocardia and Rhodococcus, as well as in mycobacteria, determined the capacity of the former to sensitize experimental animals to tuberculin, with should be taken into consideration in making the allergic test to tuberculosis.
Caspian Zonal Research Institute of Veterinary, Makhachkala, Daghestan, Russia.
R A
RA
Nuratinov
I V
IV
Efendiev
D000818:Animals; D001424:Bacterial Infections / Q000276:immunology* / Q000382:microbiology; D006967:Hypersensitivity; D011817:Rabbits; D014373:Tuberculin / Q000009:adverse effects*
D014373:Tuberculin