In vitro activity of teicoplanin against gram-positive cocci.
The glycopeptide susceptibility of 443 clinical isolates of gram-positive cocci collected from nine general hospitals in 1996 was determined according to the recommendations of the CA-SFM (the Antibiogram Committee of the French Society for Microbiology). In total, 234 isolates of Staphylococcus aureus, 84 isolates of coagulase-negative staphylococci (CNS), 98 enterococci and 27 streptococci were collected. The mecA gene confirming resistance to methicillin was found in 42.7% of S. aureus isolates and 51.2% of CNS isolates. No resistance to teicoplanin and vancomycin was found in S. aureus but four isolates of CNS had an MIC of teicoplanin > or = 8 mg/L. All isolates of Enterococcus faecalis tested were susceptible to both glycopeptides. This study confirms that teicoplanin has a very good in vitro activity against gram-positive cocci, isolated in France from nosocomial infections.
Allouch
P
P
Service d'hygiène hospitalière, hôpital A.-Mignot, 177, route de Versailles, 78150 Le Chesnay, France. pallouch@ch-versailles.fr
Pina
P
P
Chaplain
C
C
Delarbre
J M
JM
Geffroy
F
F
Grasmick
C P
CP
Marcolin
M
M
Morel
A
A
Pangon
B
B
Rio
Y
Y
Sédaillan
A
A
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000235:genetics; D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D006095:Gram-Positive Cocci / Q000187:drug effects*; D006769:Hospitals, General; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D046915:Penicillin-Binding Proteins; D013210:Staphylococcus / Q000187:drug effects / Q000235:genetics; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics; D013291:Streptococcus / Q000187:drug effects; D017334:Teicoplanin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D046915:Penicillin-Binding Proteins; C487789:mecA protein, Staphylococcus aureus; D017334:Teicoplanin