Tissue factor, the blood, and the arterial wall.
Thrombogenic tissue factor (TF) on cell-derived microparticles is present in the circulating blood of patients with acute coronary syndromes. Recently, we reported that leukocytes transfer TF-positive particles to platelet thrombi, making them capable of triggering and propagating thrombus growth. This observation changes the original dogma that vessel-wall injury and exposure of tissue factor within the vasculature to blood is sufficient for the occurrence of arterial thrombosis. The transfer of TF-positive leukocyte particles is dependent on the interaction of CD15 and TF with platelet thrombi. The inhibition of TF transfer and TF activity suggests a novel therapeutic approach to the prevention of thrombosis that may prove to be effective in disorders associated with increased blood TF.
Rauch
U
U
Division of Thrombosis Research, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
Nemerson
Y
Y
D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology*; D006801:Humans; D013925:Thromboplastin / Q000378:metabolism* / Q000502:physiology*; D013927:Thrombosis / Q000097:blood* / Q000503:physiopathology*
D013925:Thromboplastin