[Clinical efficacy of carvedilol in patients with severe cardiac insufficiency].
OBJECTIVE
To assess clinical response to carvedilol in long-term treatment of cardiac failure (CF).


METHODS
34 patients with CF (NYHA functional class III-IV) were observed for 6 months. 25 of them received standard therapy combined with carvedilol, 9 patients received only standard therapy.


RESULTS
Carvedilol produced positive changes in the disease functional class, left ventricular ejection fraction, stabilisation of echo-CG parameters and cardiothoracic index, resulted in prolongation of 6-min walk distance. Discontinuation of carvedilol therapy enhances CF symptoms.


CONCLUSIONS
Long-term therapy with carvedilol inhibits CF progression.
M Iu
MIu
Sitnikova
O O
OO
Bol'shakova
I S
IS
Brodskaia
S N
SN
Kozlova
A N
AN
Krutikov
E V
EV
Shliakhto
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D000077261:Carvedilol; D005260:Female; D006333:Heart Failure / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D014463:Ultrasonography
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D000077261:Carvedilol