Fast measurements of the motion and velocity spectrum of blood using MR tagging.
A new method is presented for tracking the motion of blood and determining its velocity spectrum from magnetic resonance data collected within a single heartbeat. The method begins by tagging a column of blood in a vessel by combining a 1D SPAMM excitation with a 2D cylindrical excitation. A series of 1D projections of the tagging pattern is acquired from a train of gradient echoes. The influence of specific excitation profiles and velocity profiles on the motion of the tags is explored for steady flow. It is shown mathematically, and confirmed with phantom experiments, that the velocity of a tag equals the mean velocity of the excited fluid when the velocity spectrum is symmetric about its mean velocity. The velocity spectrum is derived by analyzing the interference between tags moving at different velocities. This appears to be the first use of magnitude tagging to obtain velocity spectra. Representative measurements in a human aorta are presented to assess feasibility in vivo. Magn Reson Med 45:461-469, 2001.
Department of Medical Biophysics, University of Toronto and Sunnybrook & Women's Health Sciences Centre, Toronto, Canada. christopher.macgowan@sickkids.on.ca
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Macgowan
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Wood
D001011:Aorta; D001783:Blood Flow Velocity / Q000502:physiology*; D005240:Feasibility Studies; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008955:Models, Cardiovascular; D019047:Phantoms, Imaging