beta Cell autoimmunity in a child with M.O.D.Y. (Maturity Onset Diabetes in the Young).
We present the case of a well characterised M.O.D.Y. type 2 diabetes family in which one of the children associated beta cell autoimmunity and a HLA DQB1 at risk for immune-mediated type 1 diabetes mellitus. The search for autoantibodies against beta cell should be considered in cases of genetically defined form of diabetes mellitus to exclude the possibility of a concomitant risk to develop type 1 diabetes mellitus.
Pediatric Endocrine and Diabetes Unit, INSERM U457, Robert Debré Hospital, Paris, France. eduardoortega@mixmail.com
E
E
Ortega-Rodriguez
C
C
Levy-Marchal
S
S
Guillermine
M
M
Polak
D001323:Autoantibodies / Q000097:blood*; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000235:genetics / Q000276:immunology*; D018392:Genomic Imprinting; D005941:Glucokinase / Q000235:genetics; D005951:Glucose Tolerance Test; D005968:Glutamate Decarboxylase / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics*; D059866:HLA-DQ beta-Chains; D006650:Histocompatibility Testing; D006801:Humans; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D020125:Mutation, Missense
D001323:Autoantibodies; D001786:Blood Glucose; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D007328:Insulin; C024211:islet cell antibody; D005941:Glucokinase; D005968:Glutamate Decarboxylase