Diversity of two short tandem repeat loci (CD4 and F13A1) in three Brazilian ethnic groups.
Two microsatellites (CD4 and F13A1) were investigated in seven Brazilian populations: one group each of European- and African-derived subjects from Porto Alegre, southern Brazil, and five Amerindian tribes (three Tupi-Mondé speaking [Gavião, Surui, and Zoró], one Macro-Gê [Xavante], and one Carib [Wai-Wai]). For both markers, neo-Brazilians presented with a high diversity, but Amerindians showed a low level of variability. Genotype frequency distributions were heterogeneous among populations, the only exception being similar CD4 frequencies in Afro- and Euro-Brazilians. Gene diversity analysis revealed that most of the total variation is due to intrapopulational diversity in all populations. Because of the high information content of these markers in Afro- and Euro-Brazilians, these systems are most appropriate for forensic analyses. The comparison among Brazilian and other world populations revealed high similarity among populations of the same ethnic group, indicating a high discriminative power for these markers.
Bogdawa
H M
HM
Departamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
Hutz
M H
MH
Salzano
F M
FM
Weimer
T A
TA
D001938:Brazil; D015704:CD4 Antigens / Q000235:genetics; D005006:Ethnicity / Q000235:genetics*; D005176:Factor XIII / Q000235:genetics; D005787:Gene Frequency; D014644:Genetic Variation; D006579:Heterozygote; D006801:Humans; D018895:Microsatellite Repeats
D015704:CD4 Antigens; D005176:Factor XIII