[Effects of bofu-tsusho-san, a traditional Chinese medicine, on body fat accumulation in fructose-loaded rats].
The effects of Bofu-tsusho-san (BOF), a traditional Chinese medicine, on fructose-induced hypertriglyceridemia and body fat accumulation were investigated in female SD rats. Rats were allowed to drink ad libitum 25% (w/w) fructose solution for 6 weeks. BOF was administered to the rats as an experimental diet containing 1.5% or 4.5% (w/w) of BOF during the fructose-loading period. BOF suppressed body weight gain and prevented the elevation of serum triglyceride levels and body fat accumulation in fructose-loaded rats without affecting food and fructose intake. Furthermore, BOF prevented the increase of triglyceride content in the liver and the reduction of mitochondrial cytochome c oxidase activity in the brown adipose tissue induced by fructose. From these results, it has been suggested that BOF has a preventive effect against the body fat accumulation caused by excess intake of sugar or other fructose-containing foods. The inhibition of triglyceride synthesis in the liver, and the enhancement of lipolysis in adipocytes and of thermogenesis in brown adipose tissue have been presumed as the mechanisms of action of BOF.
Kampo & Healthcare Research Laboratories, Kanebo, Ltd., 1-5-90, Tomobuchi-cho, Miyakojima-ku, Osaka 534-0016, Japan. morimoto@phm.kanebo.co.jp
Y
Y
Morimoto
M
M
Sakata
A
A
Ohno
T
T
Maegawa
S
S
Tajima
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D003864:Depression, Chemical; D004040:Dietary Carbohydrates / Q000009:adverse effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D003576:Electron Transport Complex IV / Q000378:metabolism; D005260:Female; D005632:Fructose / Q000009:adverse effects*; D015228:Hypertriglyceridemia / Q000517:prevention & control; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology; D009765:Obesity / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control; D051381:Rats; D017208:Rats, Wistar; D022722:Thermogenesis / Q000187:drug effects
D004040:Dietary Carbohydrates; D004365:Drugs, Chinese Herbal; C098310:bofu-tsusho-san; D005632:Fructose; D003576:Electron Transport Complex IV