Transcription factor regulation of B lineage commitment.
The past year has provided insight into the mechanisms by which multipotent progenitors commit to differentiation through the B lymphocyte lineage. Mice lacking the Pax5 gene develop pro-B lymphocytes but these cells are not uniquely committed to the B lineage as they can give rise to all hematopoietic cell types if cultured under appropriate conditions. Regulators of lymphocyte proliferation and survival have also been identified that may allow lymphocytes to respond to information provided by the external environment.
University of California, San Diego, Department of Biology, MC0366, 9500 Gilman Drive, La Jolla, CA 92093, USA.
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D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism*; D051792:Basic Helix-Loop-Helix Proteins; D019070:Cell Lineage; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D051821:Lymphoid Enhancer-Binding Factor 1; D009687:Nuclear Proteins / Q000502:physiology; D051757:PAX5 Transcription Factor; D011518:Proto-Oncogene Proteins / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology*; D000099232:Proto-Oncogene Protein Spi-1
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D051821:Lymphoid Enhancer-Binding Factor 1; D009687:Nuclear Proteins; D051757:PAX5 Transcription Factor; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000099232:Proto-Oncogene Protein Spi-1; C081976:EBF1 protein, human; C497281:PAX5 protein, human; C407909:TCF3 protein, human