Discovery of a novel murine type C retrovirus by data mining.
Analysis of genomic and expression data allows both identification and characterization of novel retroviruses. We describe a recombinant type C murine retrovirus, similar to the Mus dunni endogenous retrovirus, with VL30-like long terminal repeats and murine leukemia virus-like coding sequences. This virus is present in multiple copies in the mouse genome and expressed in a range of mouse tissues.
Department of Zoology, University of Queensland, Brisbane 4072, Australia. LBromham@zoology.uq.edu.au
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Bromham
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Clark
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McKee
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016208:Databases, Factual; D020077:Endogenous Retroviruses / Q000145:classification* / Q000235:genetics; D020224:Expressed Sequence Tags; D017988:Gammaretrovirus / Q000145:classification* / Q000235:genetics; D020869:Gene Expression Profiling; D016678:Genome; D016679:Genome, Viral; D051379:Mice / Q000821:virology*; D008969:Molecular Sequence Data; D011533:Proviruses / Q000235:genetics; D017422:Sequence Analysis, DNA; D020079:Terminal Repeat Sequences