[A case report of radiation-induced cancer of the buccal mucosa, effectively treated with CF therapy].
We report favorable effect of combination chemotherapy with CDDP and 5-FU for a case of radiation-induced cancer of the left buccal mucosal membrane. A 71-year-old man underwent external-beam radiotherapy for a squamous cell carcinoma of the tongue. He developed left buccal mucosal cancer 13 years after the start of this radiotherapy. One course of the therapeutic regimen consisted of CDDP 70 mg/m2/day drip infusion for 2 hours (day 1) and 5-FU 700 mg/m2/day drip infusion for 120 hours (days 1-5). The patient underwent 4 courses. A partial response was achieved after 1 course, after which additional treatment with the same regimen was made with favorable effect. Four years after the treatment, 2 courses of the same chemotherapy were performed because of a recurrence of radiation-induced cancer, with a complete response. No serious side effects appeared. A histopathological examination of the lesion showed no cancer tissue. The patient was alive and cancer free 4 years after the treatment, and has been followed.
Dept. of Dentistry and Oral Surgery, Jichi Medical School.
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Watanabe
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Numao
D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D002945:Cisplatin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D009061:Mouth Mucosa; D009062:Mouth Neoplasms / Q000188:drug therapy* / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy*; D014062:Tongue Neoplasms / Q000532:radiotherapy
D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D002945:Cisplatin; D005472:Fluorouracil