Anti-nociceptive effect of neuropeptide Y in periaqueductal grey in rats with inflammation.
Experimental inflammation was induced by subcutaneous injection of carrageenan into the left hindpaw of rats. Intra-periaqueductal grey (PAG) injection of 0.02 or 0.1 nmol of neuropeptide Y (NPY), but not 0.004 nmol, induced significant increases in hindpaw withdrawal latency (HWL) to thermal and mechanical stimulation in rats with inflammation. Furthermore, the anti-nociceptive effect of NPY was blocked partly by following intra-PAG injection of the Y1 receptor antagonist NPY28-36. The results demonstrated that NPY plays an anti-nociceptive role in PAG in rats with inflammation, in which Y1 receptor is involved.
Department of Physiology, College of Life Science, Peking University, Beijing, People's Republic of China.
J Z
JZ
Wang
T
T
Lundeberg
L C
LC
Yu
D000818:Animals; D002351:Carrageenan; D004195:Disease Models, Animal; D006614:Hindlimb / Q000294:innervation; D006358:Hot Temperature; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008845:Microinjections; D009478:Neuropeptide Y / Q000008:administration & dosage*; D010147:Pain Measurement / Q000187:drug effects*; D010446:Peptide Fragments / Q000008:administration & dosage*; D010487:Periaqueductal Gray / Q000187:drug effects*; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time / Q000187:drug effects; D017476:Receptors, Neuropeptide Y / Q000037:antagonists & inhibitors
C428724:NPY(28-36); D009478:Neuropeptide Y; D010446:Peptide Fragments; D017476:Receptors, Neuropeptide Y; C097212:neuropeptide Y-Y1 receptor; D002351:Carrageenan