Anti-inflammatory activity of Dalbergia sissoo leaves.
The possible anti-inflammatory activity of the 90% ethanolic extract of Dalbergia sissoo leaves (DSELE) was studied in different models of inflammation in rats after oral administration at doses of 100, 300 and 1000 mg/kg. DSELE significantly inhibited carrageenin, kaolin and nystatin-induced paw oedema, as well as the weight of granuloma induced by a cotton pellet. It also inhibited dye leakage in acetic acid-induced vascular permeability test in mice. DSELE was devoid of ulcerogenic effect on the gastric mucosa of rats in acute and chronic tests. In acute toxicity studies, it was found to be safe up to 10.125 g/kg, p.o. in the rat. It was concluded that the D. sissoo leaf extract possessed significant anti-inflammatory activity (in acute, sub-acute and chronic models of inflammation) without any side effect on gastric mucosa.
Hajare
S W
SW
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, -243 122 (U.P.), Izatnagar, India.
Chandra
S
S
Sharma
J
J
Tandan
S K
SK
Lal
J
J
Telang
A G
AG
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D007616:Kaolin; D008297:Male; D051379:Mice; D009761:Nystatin; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D009761:Nystatin; D007616:Kaolin; D002351:Carrageenan