[Molecular imaging in magnetic resonance tomography and nuclear medicine].
The identification of genetic and biochemical changes allows a more conclusive characterization and classification of disease. Up to now this information is mostly obtained through in vitro analysis after resection or biopsy by immunohistopathology and molecular biology. There is a definite need for non-invasive detection and repeated monitoring of such changes in experimental research as well as in clinical trials. Therefore, it is necessary to develop radiological imaging techniques that not only visualize morphologic and physiologic alterations, but track genetic and biochemical processes. This short review reports some of the various ongoing research projects that address this problem and provide some very promising approaches.
Högemann
D
D
Center for Molecular Imaging Research, Massachusetts General Hospital, Building 149, 13th Street, 5403 Charlestown, MA 02129, USA. hoegeman@helix.mgh.harvard.edu
Basilion
J P
JP
Weissleder
R
R
D000818:Animals; D015415:Biomarkers / Q000032:analysis; D005819:Genetic Markers; D015316:Genetic Therapy; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008967:Molecular Biology / Q000379:methods*; D009683:Nuclear Medicine / Q000379:methods*; D012680:Sensitivity and Specificity
D015415:Biomarkers; D005819:Genetic Markers