[A three component water-biopolymer-ions system: a model for molecular mechanisms of osmotic homeostasis].
It is shown that water-ion homeostasis in a water-biopolymer-salt system is realized when proportion of the concentrations of the components changes in the definite range. The mechanism of instantaneous osmotic regulating reaction is discussed, which is based on the ability of the system to physicochemical redistribution of the components of the solution and the formation of supramolecular structures in the form of dynamic biopolymer clusters. Quasiequilibrium biopolymer<-->cluster leads to changes in the properties of the hydration water phase that provide the stabilization of water activity and the ability of hydration water to dissolve electrolyte ions. It regulates osmotic pressure and surface tension in water-protein matrix. This process supports a balance of stabilizing and destabilizing forces that affect protein structure and determine its functional activity.
Institute of Biology, Karelian Research Center, Russian Academy of Sciences, ul. Pushkinskaya 11, Petrozavodsk, 185610 Russia.
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Rozhkov
D000465:Algorithms; D001704:Biopolymers / Q000737:chemistry*; D006706:Homeostasis; D007477:Ions / Q000737:chemistry*; D008954:Models, Biological; D009995:Osmosis; D014867:Water / Q000737:chemistry*
D001704:Biopolymers; D007477:Ions; D014867:Water