Regulating cellular actin assembly.
Cellular actin assembly is tightly regulated. The study of pathogen motility has led to the identification of several cellular factors that are critical for controlling this process. Pathogens such as Listeria require Ena/VASP and Arp2/3 proteins to translate actin polymerization into movement. Recent work has extended these observations and uncovered some similarities and surprising differences in the way cells and pathogens utilize the actin cytoskeleton.
Department of Biology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139, USA.
J E
JE
Bear
M
M
Krause
F B
FB
Gertler
D051377:Actin-Related Protein 2; D000199:Actins / Q000378:metabolism*; D000818:Animals; D001426:Bacterial Proteins / Q000378:metabolism; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism; D008089:Listeria monocytogenes / Q000502:physiology; D008565:Membrane Proteins / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism; D011485:Protein Binding; D012763:Shigella flexneri / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism; D051300:Wiskott-Aldrich Syndrome Protein Family
D051377:Actin-Related Protein 2; D000199:Actins; D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D008565:Membrane Proteins; D008840:Microfilament Proteins; D014157:Transcription Factors; D051300:Wiskott-Aldrich Syndrome Protein Family; C058483:virG protein, Shigella flexneri; C072980:actA protein, Listeria monocytogenes