[The role of cytokeratin 7 in the differential diagnosis of primary ovarian carcinoma and metastatic ovarian carcinoma originated from the gastrointestinal tract].
OBJECTIVE
To assess the role of cytokeratin 7 monoclonal antibody in the differential diagnosis of primary ovarian carcinoma and metastatic ovarian carcinoma originated from the gastrointestinal tract.


METHODS
Immunohistochemical study using cytokeratin 7 monoclonal antibody and ABC kit.


RESULTS
All the 46 cases of primary ovarian carcinoma were CK 7 positive, while in the metastatic ovarian carcinoma of intestinal origin, all cases remained negative for CK7. Half of the 34 cases of metastatic ovarian carcinoma of gastric origin were CK 7 positive. The positive result of CK7 was significantly higher in the primary ovarian carcinoma than in each group of the metastatic ovarian carcinoma (P < 0.001).


CONCLUSIONS
CK 7 is seemed to be a useful antibody in the differential diagnosis of ovarian carcinoma.
Department of Pathology, Shanghai Medical University, Cancer Hospital, 200032.
W
W
Yang
T
T
Zhang
M
M
Shen
D000911:Antibodies, Monoclonal / Q000032:analysis; D018269:Carcinoma, Endometrioid / Q000276:immunology / Q000556:secondary; D018282:Cystadenocarcinoma, Mucinous / Q000276:immunology / Q000556:secondary; D018284:Cystadenocarcinoma, Serous / Q000276:immunology / Q000556:secondary*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007414:Intestinal Neoplasms / Q000276:immunology / Q000473:pathology; D053552:Keratin-7; D007633:Keratins / Q000276:immunology*; D010051:Ovarian Neoplasms / Q000276:immunology / Q000473:pathology / Q000556:secondary*; D013274:Stomach Neoplasms / Q000276:immunology / Q000473:pathology*
D000911:Antibodies, Monoclonal; C507497:KRT7 protein, human; D053552:Keratin-7; D007633:Keratins