[Protective effect of puerarin on acute cerebral ischemia in rats].
Acute incomplete brain ischemia in rats was induced by bilateral carotid artery occlusion(BCAO). BCAO results in severe suppression of EEG and increase of brain water content. Left middle cerebral artery occlusion(MCAO) in rats by electrical coagulation results in increase of brain water content of ipsilateral hemisphere and contralateral hemiparesis. The typical ischemic neuropathological damage emerges in both BCAO and MCAO models. Intraperitoneal injection of puerarin significantly helps improve all these brain ischemic disturbances.
Center of Physiology and Pharmacology, Shandong Academy of Medical Sciences, Jinan 250062.
L
L
Wang
A
A
Zhao
F
F
Wang
Q
Q
Chai
X
X
Chai
D000818:Animals; D001921:Brain / Q000473:pathology; D002545:Brain Ischemia / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007529:Isoflavones; D018696:Neuroprotective Agents; C033607:puerarin