Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family.
p73, a member of the p53 family, has been shown to exhibit similar biochemical activities to that of p53. However, in contrast to p53, p73 is rarely mutated in human tumors and p73 mutant mice develop neurological, pheromonal, and inflammatory defects, but not spontaneous tumors. Furthermore, p73 mutant mice are deficient in the physiological control of cerebral spinal fluid. To determine what mediates these p73 activities, cDNA subtraction assay was performed to identify cellular genes that are regulated by p73. We found that aquaporin 3 (AQP3), a glycerol and water transporter, is regulated by p73. In addition, we identified a potential p53 response element in the promoter of the AQP3 gene, which is responsive to p73. This suggests that AQP3 may mediate the activity of p73 in maintaining cerebral spinal fluid dynamics.
CB-2803, Institute of Molecular Medicine and Genetics, Medical College of Georgia, Augusta, GA 30912, USA.
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D051400:Aquaporin 3; D020346:Aquaporins / Q000235:genetics* / Q000378:metabolism; D001692:Biological Transport; D018076:DNA, Complementary / Q000032:analysis; D004268:DNA-Binding Proteins / Q000502:physiology*; D005786:Gene Expression Regulation; D016147:Genes, Tumor Suppressor; D005990:Glycerol / Q000378:metabolism*; D006801:Humans; D009687:Nuclear Proteins / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000737:chemistry; D025521:Tumor Suppressor Proteins; D014867:Water / Q000378:metabolism*
C496027:AQP3 protein, human; D020346:Aquaporins; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D012333:RNA, Messenger; C000606460:TP73 protein, human; C000606368:Trp73 protein, mouse; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; D014867:Water; D051400:Aquaporin 3; D005990:Glycerol