[Investigation of the clinicopathologic features, immunophenotype and Epstein-Barr virus infection of the upper respiratory tract lymphomas in patients].
OBJECTIVE
To study the clinicopathologic features, immunophenotype and Epstein-Barr virus (EBV) infection of the upper respiratory tract lymphomas in patients from north China.


METHODS
112 cases of upper respiratory tract lymphomas in patients from north China were investigated. HE stain for histologic features. Immunohistochemistry studies were performed using monoclonal antibodies, UCHL-1 for T-lymphocyte, L26 and 4KB5 for B lymphocyte, CS1-4 for latent membrane protein-1 (LMP-1). In situ hybridization for EBV encoded small nuclear RNA (EBER 1/2, Y017, DAKO).


RESULTS
77/112 cases (68.75%) were T-cell lymphomas, 35 cases (31.25%) were B cell lymphomas. EBV-EBER 1/2 in situ hybridization positive in 54/101 (53.46%) cases, including 48 T-cell lymphoma cases and 6 B-cell lymphoma cases.


CONCLUSIONS
Most upper respiratory tract lymphoma cases in patients from north China are T-cell lymphomas and are strongly associated with EBV.
Gao
Z
Z
Department of Pathology, Beijing Medical University, Beijing 100083.
Wang
H
H
Pan
Z
Z
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000473:pathology / Q000821:virology; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology* / Q000821:virology; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000276:immunology / Q000473:pathology / Q000821:virology; D009669:Nose Neoplasms / Q000276:immunology / Q000473:pathology* / Q000821:virology; D016601:RNA-Binding Proteins / Q000032:analysis*; D012269:Ribosomal Proteins
D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human