TRH activates mesolimbic dopamine system: behavioural evidence.
The effect of TRH pretreatment on locomotor activity and stereotypy induced by d-amphetamine was examined in rats. The results show that TRH potentiates d-amphetamine-induced locomotor activity, but not d-amphetamine-induced stereotypy, suggesting that this neuropeptide selectively activates the mesolimbic dopamine system.
Collu
M.
M
Dipartimento di Neuroscienze "B.B. Brodie", Università degli Studi di Cagliari, Via Porcell 4, 1-09124 Cagliari, Italy.
D'Aquila
P.S.
PS
Gessa
G.L.
GL
Serra
G.
G