Plasma thrombomodulin levels in children with atopic dermatitis.
Plasma thrombomodulin (TM) levels were measured in 68 patients with atopic dermatitis (AD) and 35 controls. Plasma TM levels in patients with AD were significantly higher than those of controls (p < 0.01). A significant correlation was observed between plasma TM levels and skin scores of AD or peripheral eosinophil counts (p < 0.01). There was also a positive correlation between plasma TM and vascular cell adhesion molecule-1 levels (p < 0.05).


CONCLUSIONS
These results suggest that plasma TM levels may reflect a severity of AD and/or endothelial cell activation induced by an allergic inflammation.
Department of Paediatrics, Kansai Medical University, Moriguchi, Osaka, Japan.
S
S
Yoshijima
T
T
Kojima
M
M
Sasai
K
K
Hattori
S
S
Taniuchi
Y
Y
Kobayashi
D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D004727:Endothelium / Q000276:immunology; D004804:Eosinophils / Q000276:immunology; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology; D007223:Infant; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D012720:Severity of Illness Index; D018180:Thrombomodulin / Q000097:blood* / Q000276:immunology
D018180:Thrombomodulin; D018799:Intercellular Adhesion Molecule-1; D007073:Immunoglobulin E