Subcutaneous heparin versus low-molecular-weight heparin as thromboprophylaxis in patients undergoing colorectal surgery: results of the canadian colorectal DVT prophylaxis trial: a randomized, double-blind trial.
OBJECTIVE
To compare the effectiveness and safety of low-dose unfractionated heparin and a low-molecular-weight heparin as prophylaxis against venous thromboembolism after colorectal surgery.


METHODS
In a multicenter, double-blind trial, patients undergoing resection of part or all of the colon or rectum were randomized to receive, by subcutaneous injection, either calcium heparin 5,000 units every 8 hours or enoxaparin 40 mg once daily (plus two additional saline injections). Deep vein thrombosis was assessed by routine bilateral contrast venography performed between postoperative day 5 and 9, or earlier if clinically suspected.


RESULTS
Nine hundred thirty-six randomized patients completed the protocol and had an adequate outcome assessment. The venous thromboembolism rates were the same in both groups. There were no deaths from pulmonary embolism or bleeding complications. Although the proportion of all bleeding events in the enoxaparin group was significantly greater than in the low-dose heparin group, the rates of major bleeding and reoperation for bleeding were not significantly different.


CONCLUSIONS
Both heparin 5,000 units subcutaneously every 8 hours and enoxaparin 40 mg subcutaneously once daily provide highly effective and safe prophylaxis for patients undergoing colorectal surgery. However, given the current differences in cost, prophylaxis with low-dose heparin remains the preferred method at present.
Department of Surgery, University of Toronto, Toronto, Ontario, Canada. rmcleod@mtsinai.on.ca
R S
RS
McLeod
W H
WH
Geerts
K W
KW
Sniderman
C
C
Greenwood
R C
RC
Gregoire
B M
BM
Taylor
R E
RE
Silverman
K G
KG
Atkinson
M
M
Burnstein
J C
JC
Marshall
C J
CJ
Burul
D R
DR
Anderson
T
T
Ross
S R
SR
Wilson
P
P
Barton
D000925:Anticoagulants / Q000627:therapeutic use*; D016063:Blood Loss, Surgical; D002170:Canada / Q000453:epidemiology; D003082:Colectomy / Q000379:methods*; D004311:Double-Blind Method; D017984:Enoxaparin / Q000627:therapeutic use*; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007279:Injections, Subcutaneous; D007431:Intraoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control; D019106:Postoperative Hemorrhage / Q000453:epidemiology; D011446:Prospective Studies; D012007:Rectum / Q000601:surgery*; D013921:Thrombocytopenia / Q000453:epidemiology / Q000209:etiology; D013923:Thromboembolism / Q000453:epidemiology / Q000517:prevention & control; D020246:Venous Thrombosis / Q000453:epidemiology / Q000517:prevention & control
D000925:Anticoagulants; D017984:Enoxaparin; C006871:calcium heparin; D006493:Heparin