Notch signaling as a target in multimodality cancer therapy.
Notch signaling is an extremely conserved and widely used mechanism controlling cell fate determination. Recent evidence shows that Notch receptors regulate cell differentiation, proliferation and apoptosis in many cells, including neoplastic cells. In the context of cancer experimental immunotherapy and multimodality therapy, the Notch signaling network is acquiring increasing importance for its possible roles in both neoplastic cells and the immune system. In this review, we discuss: (i) the roles of Notch signaling in cancer cells and the immune system; and (ii) strategies through which Notch-targeting biologicals may be used to increase the effectiveness of multimodality cancer treatment, including cancer vaccines.
Cancer Immunology Program, Cardinal Bernardin Cancer Center, Loyola University Chicago, 2160 South First Avenue, Maywood, IL 60153, USA.
M S
MS
Jang
A
A
Zlobin
W M
WM
Kast
L
L
Miele
D000818:Animals; D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D003131:Combined Modality Therapy; D016373:DNA, Antisense / Q000627:therapeutic use; D004268:DNA-Binding Proteins / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology; D015316:Genetic Therapy; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D008024:Ligands; D008565:Membrane Proteins / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology / Q000503:physiopathology / Q000628:therapy*; D009687:Nuclear Proteins; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D011994:Recombinant Proteins / Q000627:therapeutic use; D015398:Signal Transduction; D014157:Transcription Factors
D000911:Antibodies, Monoclonal; D016373:DNA, Antisense; D004268:DNA-Binding Proteins; D051819:Immunoglobulin J Recombination Signal Sequence-Binding Protein; D008024:Ligands; D008565:Membrane Proteins; C497761:NOTCH1 protein, human; D009687:Nuclear Proteins; C497570:RBPJ protein, human; D051881:Receptor, Notch1; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D011994:Recombinant Proteins; D014157:Transcription Factors