[Detection of Epstein-Barr virus subtypes in Hodgkin's disease].
OBJECTIVE
To investigate Epstein-Barr virus (EBV) subtypes in Chinese patients with Hodgkin's disease (HD).


METHODS
113 cases of HD patients with EBV latent membrane protein 1 (LMP-1) and/or EBV encoded small RAN (EBER-1) positive and throat washings from 21 healthy persons were studied for EBV subtypes by polymerase chain reaction (PCR).


RESULTS
68 HD cases exhibited specific bands, in which 62 cases were EBV type A and 6 cases were EBV type B. 13 of the control washing gave rise to specific bands, of which 11 were EBV type A and 2 of EBV type B.


CONCLUSIONS
The results showed that EBV type A is predominant in Chinese HD patients and healthy individuals.
Beijing Hospital, Beijing 100730.
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Ji
D048868:Adaptor Proteins, Signal Transducing; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002352:Carrier Proteins / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D003598:Cytoskeletal Proteins; D019309:Epstein-Barr Virus Nuclear Antigens / Q000032:analysis; D005260:Female; D004854:Herpesvirus 4, Human / Q000145:classification* / Q000302:isolation & purification; D006689:Hodgkin Disease / Q000378:metabolism / Q000821:virology*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; D008297:Male; D008875:Middle Aged; D016601:RNA-Binding Proteins / Q000032:analysis; D012269:Ribosomal Proteins
D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D003598:Cytoskeletal Proteins; C421621:EBNA-5 protein, Epstein-Barr virus; D019309:Epstein-Barr Virus Nuclear Antigens; D047908:Intracellular Signaling Peptides and Proteins; D060588:LIM Domain Proteins; C484380:PDLIM7 protein, human; D016601:RNA-Binding Proteins; D012269:Ribosomal Proteins; C067169:RPL22 protein, human