Sarcoidosis 2001.
In every decade, sarcoidosis makes a chameleon-like change so its profile needs to be updated. It was first recognised as a dermatological curiosity which evolved into a multisystem disorder with bone cysts, uveitis, and intrathoracic involvement. New dimensions were uncovered by biochemistry and immunology, bringing it still nearer the elusive enigma, namely the cause of sarcoidosis. Aetiology includes an understanding of a genetic predisposition and environmental trigger factors. What was left undone in the 20th century will become evident in the 21st century with more sophisticated technology. Likewise, conventional treatments of the past will be superseded by cytokines and other magic bullets of the millennium.
James
D G
DG
Royal Free Hospital, London NW3 2QG, UK.
D000208:Acute Disease; D015415:Biomarkers / Q000032:analysis; D016516:CD4-CD8 Ratio; D002908:Chronic Disease; D018450:Disease Progression; D005260:Female; D020022:Genetic Predisposition to Disease; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011379:Prognosis; D012507:Sarcoidosis / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D015415:Biomarkers; D005938:Glucocorticoids; D014409:Tumor Necrosis Factor-alpha