Familial adenomatous polyposis: prevalence of adenomas in the ileal pouch after restorative proctocolectomy.
OBJECTIVE
To determine the prevalence of adenomas in ileal pouches from patients with familial adenomatous polyposis (FAP) and to determine whether a correlation exists between the presence of pouch adenomas and duodenal adenomas and the site of the adenomatous polyposis coli gene mutation.


BACKGROUND
Restorative proctocolectomy can markedly reduce the risk of colorectal adenocarcinoma in FAP patients. However, adenomas with the potential to progress to adenocarcinoma can develop in the duodenum, ileum, and continent ileostomy after restorative proctocolectomy. More recently, adenomas have been described in the ileal pouch after ileoanal anastomosis.


METHODS
Pouch endoscopy was offered to 167 patients with FAP who had undergone restorative proctocolectomy between January 1984 and December 1996.


RESULTS
Adenomas were found in 35% of the 85 ileal pouches examined. No invasive carcinomas were noted. The risk of developing one or more adenomas at 5, 10, and 15 years was 7%, 35%, and 75%, respectively. Patients with adenomas were more likely to have duodenal and ampullary adenomas. No correlation was detected between adenoma development and the site of the adenomatous polyposis coli mutation.


CONCLUSIONS
Adenomas are frequently found in the ileal pouch of patients after restorative proctocolectomy for FAP. Regular endoscopic surveillance of the pouch is recommended at a frequency similar to that of upper gastrointestinal endoscopy.
Parc
Y R
YR
Department of Digestive Surgery, Hôpital Saint-Antoine AP-HP, University Pierre et Marie Curie, Paris, France.
Olschwang
S
S
Desaint
B
B
Schmitt
G
G
Parc
R G
RG
Tiret
E
E
D011125:Adenomatous Polyposis Coli / Q000175:diagnosis / Q000453:epidemiology* / Q000235:genetics / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D002648:Child; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics; D010297:Paris / Q000453:epidemiology; D011183:Postoperative Complications / Q000175:diagnosis / Q000453:epidemiology* / Q000503:physiopathology; D015995:Prevalence; D016737:Proctocolectomy, Restorative; D012720:Severity of Illness Index