Restlessness related to SSRI withdrawal.
There are reports that abrupt withdrawal of various selective serotonin re-uptake inhibitors, such as fluvoxamine, can elicit in patients various withdrawal symptoms. Fluvoxamine has been widely used in Japan for approximately 1 year. However, there have been no case reports of withdrawal symptoms following abrupt fluvoxamine discontinuation in Japan. The author reports a case where the abrupt discontinuation of fluvoxamine produced restlessness in a depressed patient. The restlessness disappeared soon after the reinstatement of treatment with fluvoxamine. This case report suggests that clinicians should carefully scrutinize a patient's compliance to fluvoxamine as the withdrawal symptoms observed following abrupt discontinuation might be regarded as a relapse of depression or side-effects of the medicine.
Center of Psychiatry and Neurology, Fukui Prefectural Hospital, Japan. shigehiro@p2422.nsk.ne.jp
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D000328:Adult; D003866:Depressive Disorder / Q000188:drug therapy; D016666:Fluvoxamine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D011595:Psychomotor Agitation; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome
D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors