Tuberculosis vaccine development: recent progress.
Recent years have seen a renewed effort to develop new vaccines against tuberculosis. As a result, several promising avenues of research have developed, including the production of recombinant vaccines, auxotrophic vaccines, DNA vaccines and subunit vaccines. In this article we briefly review this work, as well as consider the pros and cons of the animal models needed to test these new vaccines. Screening to date has been carried out in mouse and guinea pig models, which have been used to obtain basic information such as the effect of the vaccine on bacterial load, and whether the vaccine can prevent or reduce lung pathology. The results to date lead us to be optimistic that new candidate vaccines could soon be considered for evaluation in clinical trials.
Mycobacteria Research Laboratories, Dept of Microbiology, Colorado State University, Fort Collins, CO 80523, USA. iorme@lamar.colostate.edu
I M
IM
Orme
D N
DN
McMurray
J T
JT
Belisle
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D012106:Research; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D014611:Vaccination; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology; D022223:Vaccines, Subunit / Q000008:administration & dosage / Q000276:immunology
D001500:BCG Vaccine; D001428:Bacterial Vaccines; D019444:Vaccines, DNA; D022223:Vaccines, Subunit