Dose perturbations by high atomic number materials in intravascular brachytherapy.
OBJECTIVE
In intravascular brachytherapy, use of high atomic number materials, such as contrast agents and metallic stents, can introduce significant dose perturbations, especially for low energy photons. The purpose of this study is to investigate dose perturbation at the interfaces of high atomic number materials and tissue.


METHODS
To investigate this issue, the radial dose functions across the interface between different materials and soft tissue were calculated by using Monte Carlo simulations. Various interfaces, including contrast agent to water, stainless steel to water, and bone (simulating a calcified plaque) to water, were investigated for photon energies between 20 keV and 1 MeV.


RESULTS
It was found that the dose to water near the interface is enhanced considerably by photons of energies between 0.020 and 0.200 MeV. For example, the maximum dose enhancement factors for the Hypaque-tissue interface ranged from 2.2 to 18.3 for photons in this energy range. The enhancement factor is almost equal to 1 for photon energy between 0.400 and 1.000 MeV. It appears that the maximum enhancement occurs around 60 keV. For 60-keV photons, the maximum dose enhancement factors are about 18.3, 18.7, 19.1, and 3.1 for Hypaque, Omnipaque, stainless steel, and calcified plaque, respectively. The dose enhancement decreases exponentially with distance from the interface. The affected tissue thickness is dependent on the photon energy. As expected, the higher the photon energy is, the larger is the affected tissue thickness. Depending on the type of interface and the energy of photons, the dose enhancement distance (defined as the thickness receiving more than twice the dose without interface) ranges from 1.3 to 72 microm for photons of energy from 0.020 to 0.100 MeV, respectively.


CONCLUSIONS
The existense of high atomic number materials could introduce significant dose enhancement at the interfaces between these materials and tissue. This dose enhancement can be higher than an order of magnitude for photon energies around 60 keV, and should be considered in evaluation of the efficacy of intravascular brachytherapy.
Department of Therapeutic Radiology, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
R
R
Nath
N
N
Yue
J
J
Weinberger
D001918:Brachytherapy; D002114:Calcinosis; D003198:Computer Simulation; D003287:Contrast Media; D003327:Coronary Disease / Q000532:radiotherapy*; D003331:Coronary Vessels / Q000528:radiation effects; D003973:Diatrizoate; D006801:Humans; D007472:Iohexol; D009010:Monte Carlo Method; D017785:Photons; D011854:Radiochemistry; D011879:Radiotherapy Dosage; D013193:Stainless Steel; D015607:Stents
D003287:Contrast Media; D003973:Diatrizoate; D013193:Stainless Steel; D007472:Iohexol