Vilsmeier formylation of praziquantel: synthesis and application for polarographic assay.
A simple and sensitive method for the polarographic determination of praziquantel (1) after derivatization using Vilsmeier formylation is described. The polarographically active compound obtained by this procedure has been separated, identified and prepared using N,N-dimethylformamide and phosphorus oxychloride.
Kim
E J
EJ
Pharmazeutisches Institut, Universität Kiel, Germany.
Hänsel
W
W
Heber
D
D
D000980:Antiplatyhelmintic Agents / Q000032:analysis* / Q000737:chemistry; D004126:Dimethylformamide; D004566:Electrodes; D005561:Formates / Q000032:analysis / Q000138:chemical synthesis; D017553:Phosphorus Compounds; D011048:Polarography; D011223:Praziquantel / Q000032:analysis* / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D000980:Antiplatyhelmintic Agents; D005561:Formates; D017553:Phosphorus Compounds; D011223:Praziquantel; D004126:Dimethylformamide; C013196:phosphoryl chloride