Analysis of illicit drugs by nonaqueous capillary electrophoresis and electrochemical detection.
Nonaqueous capillary electrophoresis (NACE) was applied to the determination of illicit drugs. The complete separation of amphetamine, methamphetamine, 3,4-methylene dioxy amphetamine (MDA), 3,4-methylene dioxy methamphetamine (MDMA), mescaline, cocaine and benzoylecgonine was obtained using an acetonitrile based buffer solution containing 10 mM sodium acetate and 1 M acetic acid. Electrochemical detection using a Pt microdisk electrode set to a potential of +1.8 V was found to be selective for MDA, MDMA and mescaline. The detection limits for these compounds were in the low ng/mL range which is between 2 and 3 orders of magnitude lower compared to UV-detection.
University of Kansas, Department of Chemistry, Lawrence 66045, USA.
U
U
Backofen
F M
FM
Matysik
W
W
Hoffmann
C E
CE
Lunte
D015104:3,4-Methylenedioxyamphetamine / Q000032:analysis; D000097:Acetonitriles / Q000737:chemistry; D000662:Amphetamines / Q000032:analysis*; D003042:Cocaine / Q000031:analogs & derivatives / Q000032:analysis; D019075:Electrophoresis, Capillary / Q000295:instrumentation / Q000379:methods*; D006213:Hallucinogens / Q000032:analysis; D006801:Humans; D018817:N-Methyl-3,4-methylenedioxyamphetamine / Q000032:analysis; D012680:Sensitivity and Specificity; D015813:Substance Abuse Detection / Q000379:methods*
D000097:Acetonitriles; D000662:Amphetamines; D006213:Hallucinogens; D015104:3,4-Methylenedioxyamphetamine; D003042:Cocaine; D018817:N-Methyl-3,4-methylenedioxyamphetamine; C032159:acetonitrile