Maternal and perinatal brain aromatase: effects of dietary soy phytoestrogens.
Phytoestrogens are extensively investigated for their potential to prevent many hormone-dependent cancers and age-related diseases, however little is known about their effects in brain. Brain aromatase and plasma phytoestrogen levels were determined in Sprague-Dawley rats fed a phytoestrogen-rich diet during pregnancy/lactation. Ingested phytoestrogens cross the placenta and become concentrated in maternal milk as evident from high infantile plasma concentrations. Dietary phytoestrogens, however, do not alter brain aromatase during pregnancy/lactation or perinatal development.
633 WIDB, Neuroscience Center, Brigham Young University, Provo, UT 84602, USA.
K S
KS
Weber
K D
KD
Setchell
E D
ED
Lephart
D000818:Animals; D000831:Animals, Newborn; D001141:Aromatase / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000196:embryology / Q000201:enzymology*; D004789:Enzyme Activation / Q000187:drug effects; D004968:Estrogens, Non-Steroidal / Q000097:blood / Q000494:pharmacology*; D005260:Female; D005526:Food, Formulated; D007033:Hypothalamus, Middle / Q000196:embryology / Q000201:enzymology; D007529:Isoflavones / Q000097:blood; D007774:Lactation; D008297:Male; D008431:Maternal-Fetal Exchange; D048789:Phytoestrogens; D028321:Plant Preparations; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011301:Preoptic Area / Q000196:embryology / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012737:Sex Factors; D013025:Glycine max
D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D001141:Aromatase