Glucose transport and apoptosis.
The transport and metabolism of glucose modify programmed cell death in a number of different cell types. This review presents three cell death paradigms that link a decrease in glucose transport to apoptosis. Although these pathways overlap, the glucose-dependent stimuli that trigger cell death differ. These paradigms include glucose deprivation-induced ATP depletion and stimulation of the mitochondrial death pathway cascade; glucose deprivation-induced oxidative stress and triggering of Bax-associated events including the JNK/MAPK signalling pathways; and finally hypoglycemia-regulated expression of HIF-1 alpha, stabilization of p53 leading to an increase in p53-associated apoptosis. Several examples of each paradigm are presented. Future studies of glucose transport-associated apoptotic events will allow better understanding of the role of cellular metabolism in programmed cell death.
Moley
K H
KH
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, MO, USA.
Mueckler
M M
MM
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000544:Alzheimer Disease / Q000503:physiopathology; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001692:Biological Transport; D015687:Cell Hypoxia; D002478:Cells, Cultured; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D015398:Signal Transduction
D000255:Adenosine Triphosphate; D005947:Glucose