[Searching for the optimal combinations of regulator anxiolytic peptides: theoretical rationale].
A vector method is proposed to initially select the complexes of regulatory peptides (RPs) with certain functional characteristics. As the result of a theoretical search for the optimal combinations of anxiolytic RPs with different spectra of side effects, the following complexes are proposed for subsequent experimental investigation: NPY-ANP, NPY-SP, NPY-NT, NPY-CGRP, NPY-DSIP, NPY-MIF-1, NPY-SP-MIF-1, NPY-ANP-DSIP, and NPY-CGRP-DSIP.
Koroleva
S V
SV
Biological Faculty, Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.
Ashmarin
I P
IP
D000465:Algorithms; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D001007:Anxiety / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D008954:Models, Biological; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000502:physiology; D012984:Software
D014151:Anti-Anxiety Agents; D010446:Peptide Fragments; D010455:Peptides