Circadian variation of paroxysmal atrial fibrillation. PA3 Investigators. Atrial Pacing Peri-ablation for Prevention of Atrial Fibrillation Trial.
The circadian variation of paroxysmal atrial fibrillation (AF) was studied in 67 patients who received a dual-chamber pacemaker 3 months before a planned atrioventricular node ablation. A distinct circadian variation of AF was observed with 2 time peaks in initiation (1 in the early morning and 1 in the early evening hours), which was modulated by atrial pacing, the duration of AF, and the use of beta-adrenergic blocking agents.
Division of Cardiology, The University of Calgary, Alberta, Canada. amgillis@ucalgary.ca
A M
AM
Gillis
S J
SJ
Connolly
M
M
Dubuc
R
R
Yee
P
P
Lacomb
F
F
Philippon
C R
CR
Kerr
S
S
Kimber
M J
MJ
Gardner
A S
AS
Tang
F
F
Molin
D
D
Newman
H
H
Abdollah
D000638:Amiodarone / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents; D001281:Atrial Fibrillation / Q000503:physiopathology* / Q000628:therapy; D002940:Circadian Rhythm; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone