[History, principles of construction of combined vaccine and problems of vaccine prophylaxis with their use].
This problem article deals with modern trends in the creation and use of combined vaccines, the advantage and drawbacks of multicomponent preparations. The data on competition, interference and synergism in the action of individual components making up combined vaccines, on the cellular and molecular mechanisms of the interaction of antigens are presented. Specific features of the development of immunity induced by complex vaccines with due regard to the action of genetic and phenotypic signs, as well as the formation of humoral and cell-mediated immunity. The priority of Russian researchers in the development of the first combined vaccines is pointed out. On the basis of theoretical knowledge and accumulated practical experience the main principles of the construction and properties of combined vaccines have been formulated.
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Tarasevich State Research Institute of Standardization and Control of Medical Biological Preparations, Moscow, Russia.
D006801:Humans; D007111:Immunity, Cellular; D017778:Vaccines, Combined / Q000009:adverse effects
D017778:Vaccines, Combined