Daily hunger sensation and body compartments: II. Their relationships in obese patients.
Hunger sensation (HS) is a signal whose levels change during the 24-h day. The daily mean level of HS was correlated with the human body compartments, as investigated by bioelectrical impedance analysis, to detect the relationship between the orectic perception and both the free fat mass (FFM) and the fat body mass (FBM) in 22 clinically healthy subjects (CHS) (2 M, 20 W, BMI: 18.5-24.0 kg/m2) and 48 obese patients (OP) (4 M, 44 W, BMI: 25.2-54.7 kg/m2). In CHS, the daily mean level of HS correlated positively with the FFM and negatively with the FBM. These correlations were not present in OP. This lack of relationships between HS and the body compartments where energy is maximally consumed (i.e., the FFM) and maximally stored (i.e., the FBM) indicates that the orectic response to energy expenditure and the orectic inhibition to fat accumulation are feedback mechanisms which are impaired in obesity.
Cugini
P
P
Istituto di II Clinica Medica, University of Rome La Sapienza, Italy.
Salandri
A
A
Cilli
M
M
Ceccotti
P
P
Di Marzo
A
A
Rodio
A
A
Fontana
S
S
Pellegrino
A M
AM
De Francesco
G P
GP
Coda
S
S
De Vito
F
F
Colosi
L
L
Petrangeli
C M
CM
Giovannini
C
C
D000273:Adipose Tissue / Q000503:physiopathology; D000328:Adult; D001823:Body Composition / Q000502:physiology; D017097:Electric Impedance; D004734:Energy Metabolism / Q000502:physiology; D005246:Feedback / Q000502:physiology; D005260:Female; D006801:Humans; D006815:Hunger / Q000502:physiology; D020738:Leptin / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000503:physiopathology / Q000523:psychology*; D012528:Satiety Response / Q000502:physiology
D020738:Leptin