Neovascularisation offers a new perspective to glutamine related therapy.
Angiogenesis or the generation of new blood vessel, is an important factor in the growth of a solid tumor. Hence, it becomes a necessary parameter of any kind of therapeutic study. Glutamine is an essential nutrient of tumor tissue and glutamine related therapy involves clearance of circulatory glutamine by glutaminase. Therefore, using different murine solid tumor models, the present study was undertaken to find out whether the S-180 cell glutaminase has any effect on angiogenesis of solid tumor, or not. Result indicates that the purified S-180 cell glutaminase reduces tumor volume and restrict the generation of neo blood vessels. Therefore, it can be concluded that this enzyme may be an effective device against the cancer metastasis.
Department of Metabolic Regulation, Chittaranjan National Cancer Institute, 37, S.P. Mukherjee Road, Calcutta-700 026, India.
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Maity
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Chakraborty
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Bhattacharya
D020533:Angiogenesis Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002273:Carcinogens; D002286:Carcinoma, Ehrlich Tumor / Q000098:blood supply / Q000188:drug therapy; D004354:Drug Screening Assays, Antitumor; D005972:Glutaminase / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D005973:Glutamine / Q000502:physiology*; D007274:Injections, Intraperitoneal; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D009363:Neoplasm Proteins / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D012510:Sarcoma 180 / Q000098:blood supply / Q000188:drug therapy / Q000201:enzymology*
D020533:Angiogenesis Inhibitors; D002273:Carcinogens; D009363:Neoplasm Proteins; D005973:Glutamine; D008748:Methylcholanthrene; D005972:Glutaminase