[Analgesia with oxygen-nitrous oxide mixture during percutaneous renal biopsy in children].
The efficacy of an inhaled equimolar mixture of nitrous oxide and oxygen (Entonox/MEOPA) to prevent procedural pain during renal percutaneous biopsies in children was assessed.


METHODS
One hundred and seven children who underwent 113 renal biopsies during a 17-month period were included in a prospective uncontrolled pediatric study. Efficacy was evaluated using patients' answers to a questionnaire and nurses' observations.


RESULTS
Pain was absent in 86.5% of the cases. Mild adverse events were noted in one-third of the procedures, and were always reversible within a few minutes when the inhalation stopped. Acceptability was good. The use of this gas is easy and safe provided a few precautions are observed.


CONCLUSIONS
Inhaled equimolar mixture of nitrous oxide and oxygen prevents procedural pain during renal percutaneous biopsies.
Service de néphrologie pédiatrique, hôpital Necker-Enfants-Malades, 149, rue de Sèvres, 75743 Paris, France.
C
C
Piétrement
R
R
Salomon
F
F
Monceaux
C
C
Petitjean
P
P
Niaudet
D000280:Administration, Inhalation; D000367:Age Factors; D000698:Analgesia / Q000009:adverse effects / Q000379:methods*; D019162:Anesthetics, Combined / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D001707:Biopsy, Needle / Q000009:adverse effects*; D002626:Chemistry, Pharmaceutical; D002648:Child; D004244:Dizziness / Q000139:chemically induced; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000473:pathology*; D008297:Male; D009325:Nausea / Q000139:chemically induced; D009609:Nitrous Oxide / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D010100:Oxygen / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D010146:Pain / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D010147:Pain Measurement; D011446:Prospective Studies; D016896:Treatment Outcome; D014839:Vomiting / Q000139:chemically induced
D019162:Anesthetics, Combined; C001147:Entonox; D009609:Nitrous Oxide; D010100:Oxygen