HBV-specific peptide associated with heat-shock protein gp96.
Glycoprotein 96 (gp96), a member of the heat-shock protein family, can elicit priming of antigen-specfic cytotoxic T lymphocytes, when bound to antigenic viral or tumour peptides. We used direct peptide isolation from purified gp96 and microsequencing to show that a virus-specific peptide is bound to gp96 derived from liver tissues of patients with hepatitis B virus (HBV)-induced hepatocellular carcinoma. This virus-specific peptide has potential for engineering tumour vaccines against hepatocellular carcinoma and chronic HBV infection.
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D000951:Antigens, Neoplasm / Q000378:metabolism*; D019496:Cancer Vaccines; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000821:virology; D006360:Heat-Shock Proteins / Q000378:metabolism*; D006509:Hepatitis B / Q000150:complications / Q000378:metabolism*; D006512:Hepatitis B Core Antigens / Q000378:metabolism*; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism* / Q000821:virology; D010446:Peptide Fragments / Q000378:metabolism; D011485:Protein Binding
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D006360:Heat-Shock Proteins; D006512:Hepatitis B Core Antigens; D010446:Peptide Fragments; C052646:sarcoma glycoprotein gp96 rejection antigens