The use of particle beam mass spectrometry for the measurement of impurities in a nabumetone drug substance, not easily amenable to atmospheric pressure ionisation techniques.
Liquid chromatography/particle beam mass spectrometry (LC/PB-MS) was used for the structural elucidation of some impurities in nabumetone as this compound poorly ionises by atmospheric pressure ionisation (API) techniques. PB-MS was optimised for nabumetone and a sensitivity study was carried out. To obtain full scan electron ionisation spectra a minimum of 100 ng of compound on column was needed. By using 20 mg/mL solutions of nabumetone, impurities at levels of about 250 ppm mass fraction relative to nabumetone could be detected. Results were compared with LC/API-MS and previous GC/MS.
Analytical Sciences, SmithKline Beecham Pharmaceuticals, Harlow CM19 5AW, UK.
J C
JC
Wolff
P N
PN
Hawtin
S
S
Monté
M
M
Balogh
T
T
Jones
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry* / Q000302:isolation & purification; D002074:Butanones / Q000737:chemistry* / Q000302:isolation & purification; D002853:Chromatography, Liquid / Q000379:methods; D004340:Drug Contamination; D000077430:Nabumetone; D011312:Pressure; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002074:Butanones; D000077430:Nabumetone