Fetal varicella-herpes zoster syndrome in early pregnancy: ultrasonographic and morphological correlation.
We report a case of an intrauterine fetal infection by the varicella-herpes zoster virus following maternal varicella at 17 weeks' amenorrhea. Prenatal diagnosis of fetal infection was confirmed by serology and fetal damage by ultrasonography. Autopsy of the fetus showed multiorgan manifestation with disseminated foci of necrosis and microcalcifications, encephalitis and unilateral segmental skin scarring with an underlying hypoplastic fixed lower limb. The placenta showed a multifocal chronic villitis with multinucleated giant cells. The lesions included segmental anomalies and multiorgan damage.
Department of Gynecology and Obstetrics, CHUV, Lausanne, Switzerland. ppetignat@hotmail.com
P
P
Petignat
Y
Y
Vial
R
R
Laurini
P
P
Hohlfeld
D000328:Adult; D002644:Chickenpox / Q000000981:diagnostic imaging / Q000473:pathology / Q000635:transmission*; D005260:Female; D005315:Fetal Diseases / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology*; D005865:Gestational Age; D006562:Herpes Zoster / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D016216:Ultrasonography, Prenatal