Serum interleukin-6, soluble interleukin-6 receptor and soluble gp130 exhibit different patterns of age- and menopause-related changes.
Growing evidence suggests that interleukin-6 (IL-6) may play a pathogenetic role in postmenopausal bone loss and in other age-related pathological conditions. In this study, we have examined the age-related changes in the serum levels of IL-6 and the soluble receptors that modulate its biological activity--soluble IL-6 receptor (sIL-6R) and soluble gp130 (sgp130)--in 220 women (from 25 to 104yr old), including 22 centenarians. Serum IL-6 rose exponentially with age (r=0.74, p<0.0001). The median level of IL-6 increased almost ten-fold with age, from 1.16pg/ml in premenopausal women to 10.27pg/ml in centenarians. Serum sIL-6R and sgp130 showed an increase until the seventh decade and a progressive decrease in older ages (r=0.39, p<0.0001 and r=0.26, p=0.008, respectively). IL-6, sIL-6R and sgp130 were significantly higher in women within 10yr of menopause as compared to premenopausal subjects (1.51 vs. 1.16pg/ml, p=0.012; 41.9 vs. 35.7ng/ml, p=0.002; and 253.4 vs. 230.7ng/ml, p=0.008, respectively). In postmenopausal women, a negative correlation was found between sIL-6R and the lumbar bone mineral density (BMD) (r=-0.28, p=0.002) even after adjusting for age and weight. Furthermore, sIL-6R levels were higher in osteoporotic compared to normal women (47.9 vs. 39.5ng/ml, p=0.001). In conclusion, our results show that the serum levels of IL-6, sIL-6R and sgp130 exhibit different patterns of age- and menopause-related changes, and that the biological activity of IL-6 may be increased with age with potential implications in the age-related diseases such as osteoporosis.
Giuliani
N
N
Dipartimento di Medicina Interna e Scienze Biomediche, Università di Parma, via Gramsci 14, 43100, Parma, Italy.
Sansoni
P
P
Girasole
G
G
Vescovini
R
R
Passeri
G
G
Passeri
M
M
Pedrazzoni
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood* / Q000276:immunology; D058966:Contactins; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008593:Menopause / Q000097:blood* / Q000276:immunology; D008875:Middle Aged; D019006:Neural Cell Adhesion Molecules / Q000097:blood*; D017698:Postmenopause / Q000097:blood / Q000276:immunology; D017697:Premenopause / Q000097:blood / Q000276:immunology; D019947:Receptors, Interleukin-6 / Q000097:blood*; D012044:Regression Analysis
D058966:Contactins; D015850:Interleukin-6; D019006:Neural Cell Adhesion Molecules; D019947:Receptors, Interleukin-6