Future possibilities in the prevention of breast cancer: role of genetic variation in breast cancer prevention.
Risk factors for breast cancer are related to endogenous hormones and reproductive events. As such, traditional cancer prevention strategies are not easily applicable. Tamoxifen and other selective estrogen receptor modulators (SERMs) offer a new preventive strategy for some high-risk women, but have not yet been shown to be efficacious for all women. New tools to identify high-risk women are needed. One such tool is the development of a multigenic model of breast cancer susceptibility that can be used to screen women in order to identify those who carry a combination of alleles that puts them at significantly increased risk.
American Cancer Society, National Home Office, Atlanta, Georgia 30329-4251, USA.
H S
HS
Feigelson
B E
BE
Henderson
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D016588:Anticarcinogenic Agents / Q000627:therapeutic use; D001141:Aromatase / Q000235:genetics / Q000378:metabolism; D001943:Breast Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control*; D016022:Case-Control Studies; D004960:Estradiol Dehydrogenases / Q000235:genetics / Q000378:metabolism; D047628:Estrogen Receptor alpha; D004967:Estrogens / Q000378:metabolism; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005544:Forecasting; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D006801:Humans; D008875:Middle Aged; D008957:Models, Genetic; D010053:Ovary / Q000378:metabolism; D011110:Polymorphism, Genetic; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D017584:Reproductive History; D012307:Risk Factors; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use; D013254:Steroid 17-alpha-Hydroxylase / Q000235:genetics / Q000378:metabolism; D013629:Tamoxifen / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D047628:Estrogen Receptor alpha; D004967:Estrogens; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D020849:Raloxifene Hydrochloride; D004960:Estradiol Dehydrogenases; D001141:Aromatase; D013254:Steroid 17-alpha-Hydroxylase