Inactivated pronase as the cause of false-positive results of serum cryptococcal antigen tests.
Four patients who had acquired immunodeficiency syndrome and who were evaluated for headache within a 3-week period had false-positive results of serum cryptococcal antigen tests. This cluster of false-positive test results appeared to be due to inactivation of the pronase vial in the test kit, a cause that has not been reported previously.
Division of Infectious Diseases, University of Colorado Health Sciences Center, Denver, CO, USA. Thomas.Stoeckli@chuv.hospvd.ch
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D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000946:Antigens, Fungal / Q000097:blood* / Q000134:cerebrospinal fluid; D003454:Cryptococcus / Q000302:isolation & purification*; D004789:Enzyme Activation; D005189:False Positive Reactions; D006801:Humans; D007841:Latex Fixation Tests; D016919:Meningitis, Cryptococcal / Q000175:diagnosis*; D011402:Pronase / Q000378:metabolism*; D011933:Reagent Kits, Diagnostic
D000946:Antigens, Fungal; D011933:Reagent Kits, Diagnostic; D011402:Pronase