Antidepressant-associated mania and psychosis resulting in psychiatric admissions.
BACKGROUND
The safety and tolerability of the selective serotonin reuptake inhibitors and the newer atypical agents have led to a significant increase in antidepressant use. These changes raise concern as to the likelihood of a corresponding increase in adverse behavioral reactions attributable to these drugs.


METHODS
All admissions to a university-based general hospital psychiatric unit during a 14-month period were reviewed.


RESULTS
Forty-three (8.1%) of 533 patients were found to have been admitted owing to antidepressant-associated mania or psychosis.


CONCLUSIONS
Despite the positive changes in the side effect profile of antidepressant drugs, the rate of admissions due to antidepressant-associated adverse behavioral effects remains significant.
Department of Psychiatry, Yale University, New Haven, Conn 06519, USA.
A
A
Preda
R W
RW
MacLean
C M
CM
Mazure
M B
MB
Bowers
D000208:Acute Disease; D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D003237:Connecticut / Q000453:epidemiology; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy / Q000523:psychology; D008875:Middle Aged; D011567:Psychiatric Department, Hospital / Q000706:statistics & numerical data; D011605:Psychoses, Substance-Induced / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects / Q000627:therapeutic use
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic; D017367:Selective Serotonin Reuptake Inhibitors