[Effects of regulator peptides on expression of mannose-containing membrane structures in leukocytes in acute stress].
We have investigated the influence of regulative peptides (oxytocin, pituitrin, thyroid-releasing hormone and SNC) on the expression of mannose-containing membrane structures (MCMS) of lymphocytes and neutrophils in acute stress (3-hour immobilization on the back). MCMS were assayed by the indirect lectin-peroxidase test. We have found that MCMS-expression of lymphocytes significantly decreased but neutrophil MCMS-expression changed in different directions. SNC and thyroid-releasing hormone decreased and MCMS expression increased, respectively. Acute stress activated MCMS expression of lymphocytes. This activation was uncorrectable by the investigated peptides, MCMS expression of neutrophils was corrected by oxytocin, thyroid-releasing hormone and pituitrin. Thus, MCMS expression of leukocytes changed as a multimodal system by acute stress and peptide administration. This system may take part in pathogenesis of the stress reaction.
Bobrova
N A
NA
Vazhnichaia
E M
EM
Kaĭdashev
I P
IP
D000208:Acute Disease; D000818:Animals; D007962:Leukocytes / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism; D008358:Mannose / Q000737:chemistry*; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D019579:Neocortex / Q000737:chemistry; D009479:Neuropeptides / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology; D009504:Neutrophils / Q000378:metabolism; D010121:Oxytocin / Q000494:pharmacology; D010909:Pituitary Hormones, Posterior / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000097:blood / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D008565:Membrane Proteins; D009479:Neuropeptides; D010909:Pituitary Hormones, Posterior; D010121:Oxytocin; D013973:Thyrotropin-Releasing Hormone; D008358:Mannose