mRNA quality control: Marking the message for life or death.
A protein complex deposited upstream of exon-exon junctions after pre-mRNA splicing may serve a dual role in mRNA quality control by directing mRNA nuclear export and, possibly, serving as a downstream 'mark' for nonsense-mediated decay.
Department of Molecular Biophysics and Biochemistry, Yale University School of Medicine, 295 Congress Avenue, New Haven, CT 06536, USA. jl346@email.med.yale.edu
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Lykke-Andersen
D000818:Animals; D011786:Quality Control; D012322:RNA Precursors / Q000235:genetics; D012326:RNA Splicing; D012333:RNA, Messenger / Q000235:genetics*
D012322:RNA Precursors; D012333:RNA, Messenger