Effects of food deprivation and satiation on sensitivity to the discriminative-stimulus effects of pentobarbital in pigeons and morphine in rats.
Food deprivation can produce a substantial increase in the self-administration of drugs of abuse, suggesting that food deprivation increases their reinforcing properties. This finding has been replicated with a wide variety of reinforcing drugs. The present experiments examined the effects of food deprivation and satiation on the discriminative stimulus properties of drugs, to determine whether food deprivation affects the discriminative-stimulus effects of drugs in a similar manner. Using pigeons that were trained to discriminate 5mg/kg i.m. pentobarbital from saline, dose-effect curves were determined under both food-deprivation conditions (80% free-feeding body weight) and partial food-satiation conditions (25% and 50% of the amount of full satiation). It was found that generalization curves for both pentobarbital and saline were similar at all levels of food deprivation. In a second set of experiments, rats were trained to discriminate 10mg/kg i.p. morphine from saline, and the discriminative properties of morphine were then tested when the animals were either food-deprived or after a 15min supplemental feeding. The ED(50) value for the food-deprived condition was comparable to that the food-satiated condition (3.6 vs. 4.8mg/kg, respectively). Thus, in both pigeons and rats, there was little evidence that food deprivation increased sensitivity to the discriminative stimulus properties of drugs. Thus, food deprivation must increase drug self-administration by a mechanism other than by increasing the discriminative stimulus properties of self-administered drugs.
Department of Pharmacology and Toxicology, College of Medicine, University of Arkansas for Medical Sciences, 4301 West Markham Street, Little Rock, AR 72205, USA.
M.
M
Li
H.R.
HR
Garner
W.D.
WD
Wessinger
D.E.
DE
McMillan