Synthesis of sialyl Lewis(x) mimics. Modifications of the 6-position of galactose.
Seven sLe(x) mimics where the -CH2OH group of the galactose moiety is replaced by -CH2NH3+, -CH2NHAc, -CH2NHBz, -CH2OSO3Na, -COONa and -CONH2 have been prepared and tested for their binding affinity to E-selectin.
Novartis Pharma AG, Basel, Switzerland. rolf.baenteli@pharma.novartis.com
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Bänteli
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Ernst
D019040:E-Selectin / Q000378:metabolism; D005690:Galactose; D009844:Oligosaccharides / Q000138:chemical synthesis* / Q000378:metabolism; D000080506:Sialyl Lewis X Antigen; D013329:Structure-Activity Relationship
D019040:E-Selectin; D009844:Oligosaccharides; D000080506:Sialyl Lewis X Antigen; D005690:Galactose