In vivo tracking of tumor-specific T cells.
Novel immunologic assays now enable visualization of the antigen-specific response to an extent not previously possible. Assessment of not only the numeric frequency but also the functional properties of individual tumor-specific T cells in the endogenous and manipulated immune response has provided insights that will facilitate the development of immunotherapeutic strategies.
Yee
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Fred Hutchinson Cancer Research Center and University of Washington Medical Center, 1100 Fairview Avenue North, D3-100, Seattle, WA 98109, USA. cyee@fhcrc.org
Riddell
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SR
Greenberg
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PD
D019264:Adoptive Transfer; D000951:Antigens, Neoplasm / Q000276:immunology*; D019496:Cancer Vaccines / Q000276:immunology; D002634:Chemotaxis, Leukocyte; D016207:Cytokines / Q000032:analysis / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D018655:Lymphocyte Count; D009369:Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology
D000951:Antigens, Neoplasm; D019496:Cancer Vaccines; D016207:Cytokines; D006680:HLA Antigens; D007136:Immunoglobulins