Sensitization of haloperidol-induced hypophagia is contingent on behavioral experience with food.
Groups of rats were given injections of haloperiodol (0.31mg/kg) at weekly intervals either before or after access to sweetened milk. Control groups were given injections of saline. At the end of the chronic regimen, all groups received a single injection of haloperidol (0.15mg/kg) prior to milk access. Rats injected with the drug before milk during the chronic phase showed a progressive decrease in milk intake. When subsequently challenged with a lower dose, this group ingested less milk than any of the other groups, which did not differ from one other. These results demonstrate that sensitization of haloperidol-induced hypophagia is contingent on experience with milk while in the drugged state.
Institute for the Study of Alcohol and Drug Dependence, Department of Psychology, PO Box 3091, Florida Atlantic University, Boca Raton, FL 33431, USA.
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Wolgin
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Dalzell