[The pathogenetic significance of disruption of antioxidant homeostasis status in patients with hypertension].
Antioxidative homeostasis was investigated in blood plasma and lymphocytes of patients with hypertonic disease (stage II). The intensification of lipid peroxidation was accompanied by accumulation of polyenic fatty acid derivatives and toxic dialdehydes and also by mobilization of lipid soluble vitamins. Vitamin E is probably involved into direct binding of toxic LPO products. Such changes provide high antioxidant activity and normal functioning of lymphocytes.
Paranich
A V
AV
Karazin National University, Kharkov, Ukraine.
Lad
S N
SN
Frolova
N A
NA
Snegursiaia
I A
IA
Koval'
S N
SN
D000975:Antioxidants / Q000378:metabolism*; D006706:Homeostasis; D006801:Humans; D006973:Hypertension / Q000097:blood*; D015227:Lipid Peroxidation; D008214:Lymphocytes / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
D000975:Antioxidants; D014810:Vitamin E