Total body irradiation-based regimen in the conditioning of patients submitted to haploidentical stem cell transplantation.
OBJECTIVE
To evaluate the efficacy and toxicity of a highly immuno- and myelo-suppressive conditioning regimen followed by the infusion of large numbers of T-cell-depleted mismatched haematopoietic stem cells in 43 high-risk acute leukaemia patients.


RESULTS
A high rate of engraftment (95%) and no graft-versus-host disease (GvHD) were observed. The 4-year probability of event-free survival was 0.25+/-0.09 for acute myeloid leukaemia and 0.17+/-0.07 for acute lymphoid leukaemia patients.


CONCLUSIONS
This study shows that the main obstacles limiting the use of mismatched transplants, i.e. GvHD and rejection, were overcome.
Aristei
C
C
Institute of Radiotherapy Oncology, General Hospital and University, Perugia, Italy.
Latini
P
P
Terenzi
A
A
Felicini
R
R
Aversa
F
F
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D006085:Graft Survival; D006087:Graft vs Host Reaction; D006239:Haplotypes; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D007945:Leukemia, Lymphoid / Q000401:mortality / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000401:mortality / Q000628:therapy*; D008212:Lymphocyte Depletion; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D019172:Transplantation Conditioning; D014916:Whole-Body Irradiation