Saponins in garlic as modifiers of the risk of cardiovascular disease.
Most chemical and biological studies about garlic have been conducted using organosulfur compounds. However, a variety of steroid saponins from garlic and related Allium species are being increasingly recognized for their importance in biological processes. This report demonstrates the isolation and structure determination of steroid saponins from garlic and aged garlic extract (AGE). In addition, the in vitro antifungal antitumor cytotoxicity and blood coagulability effects of steroid saponins from garlic and related Allium species are provided. Animal studies on the cholesterol-lowering effects of the saponin fractions from garlic are also summarized.
Program for Collaborative Research in the Pharmaceutical Sciences, Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, IL 60612, USA.
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Matsuura
D000818:Animals; D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000627:therapeutic use; D000924:Anticholesteremic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000302:isolation & purification / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000188:drug therapy / Q000517:prevention & control*; D005737:Garlic / Q000737:chemistry*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D012307:Risk Factors; D012503:Saponins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology* / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D000924:Anticholesteremic Agents; D000935:Antifungal Agents; D010936:Plant Extracts; D012503:Saponins