Declining chloroquine resistance of Plasmodium falciparum in Lambaréné, Gabon from 1992 to 1998.
Plasmodium falciparum malaria continues to threaten human populations in the tropics and travellers in endemic areas. Drug resistance of the parasite is a major problem in treating this devastating disease. In a prospective trial we investigated the in vitro sensitivity of Plasmodium falciparum to chloroquine, quinine and mefloquine in the Albert Schweitzer Hospital in Lambaréné, Gabon every second year from 1992 to 1998. We used the standard WHO in vitro sensitivity assay. Parasite sensitivity to quinine and mefloquine remained stable over the years. However, parasite resistance to chloroquine decreased highly significantly with the change in local malaria treatment policy. In 1992, 100% of parasite isolates showed resistance to chloroquine, whereas in 1998 only 45% were found resistant.
Schwenke
A
A
Research Unit, Albert Schweitzer Hospital, Lambaréné, Gabon.
Brandts
C
C
Philipps
J
J
Winkler
S
S
Wernsdorfer
W H
WH
Kremsner
P G
PG
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology*; D004351:Drug Resistance; D005681:Gabon / Q000453:epidemiology; D006801:Humans; D066298:In Vitro Techniques; D020128:Inhibitory Concentration 50; D016778:Malaria, Falciparum / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D015767:Mefloquine / Q000494:pharmacology; D021261:Parasitic Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects*; D017410:Practice Guidelines as Topic; D011446:Prospective Studies; D011803:Quinine / Q000494:pharmacology
D000962:Antimalarials; D002738:Chloroquine; D011803:Quinine; D015767:Mefloquine