The parkin gene S/N167 polymorphism in Australian Parkinson's disease patients and controls.
This study determined the frequencies of a G-to-A transition (S/N167) polymorphism in exon 4 of the parkin gene in Australian Parkinson's disease patients and control subjects. The genotype of each subject was determined using the polymerase chain reaction and restriction-fragment-length-polymorphism analysis. Overall, the A allele was significantly less common in the Parkinson's disease group (1.7%) compared with the control group (3.8%, OR=0.43, 95% CI=0.19-1.00, P<0.05), although the frequency in the young onset Parkinson's disease group (6.6%) was not significantly different to controls. The A allele is less common in Australian Caucasian subjects compared to Japanese Parkinson's disease patients and appears to be under-represented in older-onset Parkinson's disease.
Department of Medicine, University of Queensland, Princess Alexandra Hospital, Queensland, Woolloongabba, Australia
G D.
GD
Mellick
D D.
DD
Buchanan
N
N
Hattori
A J.
AJ
Brookes
Y
Y
Mizuno
D G.
DG
Le Couteur
P A.
PA
Silburn