BRCA1 function in T lymphocytes: a cellular specificity of a different kind.
Recent work by Mak et al demonstrates that mice carrying a T-cell-specific disruption of the brca1 gene display markedly impaired T-lymphocyte development and proliferation in the absence of any increased tendency for the formation of tumors. Interestingly, the extent of these defects was found to be highly dependent on cellular context. Contrasting the rather broad tissue expression pattern of brca1 against its exquisitely selective etiologic role in cancers of the breast and ovary, many of us are left to ponder--where is the specificity?
Division of Clinical Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
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D000818:Animals; D019313:BRCA1 Protein / Q000502:physiology*; D019070:Cell Lineage; D005786:Gene Expression Regulation / Q000276:immunology; D015329:Gene Rearrangement, T-Lymphocyte / Q000276:immunology; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D019313:BRCA1 Protein