[Features of disruption of certain components of carbohydrate metabolism in a combination of pulmonary tuberculosis and diabetes mellitus in people with haptoglobin phenotypes].
Sugar level in blood, the activity of lactate dehydrogenase (LDH), glucose-6-phosphate dehydrogenase (G-6-PDH), 2,3-BPG content, HbA1C and the phenotype of haptoglobin were studied in 180 patients with lung tuberculosis and diabetes mellitus. The increased (2-4.2-fold) blood sugar level was found in 77.2% patients. It was accompanied by decreased activity of LDH (by 1.3-1.7 times), G-6-PDH (by 15-45% in 87% patients). In patients with various haptoglobin phenotypes the content of HbA1C and 2.3-BPG was increased by 1.5-1.7 and 2-3 times, respectively. Clear differences in the studied parameters were found in patients with various phenotypes of haptoglobin (Hp). The most serious impairments of the studied parameters of carbohydrate metabolism were found in untreated patients with homozygote Hp phenotypes 2-2 and 1-1. Alterations found in the present study can be used for evaluating the depth of impairments of the carbohydrate metabolism in patients with combination of lung tuberculosis and diabetes mellitus.
Parpieva
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Research Institute of Phthisiology and Pulmonology, Tashkent, Republic of Uzbekistan.
Kazakov
K S
KS
D050260:Carbohydrate Metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000201:enzymology / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006442:Glycated Hemoglobin / Q000378:metabolism; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D010641:Phenotype; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000201:enzymology / Q000378:metabolism*
D005954:Glucosephosphate Dehydrogenase; D006442:Glycated Hemoglobin; D006242:Haptoglobins; D007770:L-Lactate Dehydrogenase