Influence of octreotide and tamoxifen on tumor growth and liver metastasis in N-nitrosobis(2-oxopropyl)amine-induced pancreatic cancer in Syrian hamsters.
In prospective clinical trials single octreotide therapy or combined therapy with tamoxifen has improved the quality of life and survival time in patients with pancreatic cancer. In this study we analyzed the influence of octreotide and tamoxifen on tumor growth and liver metastases in chemically induced pancreatic adenocarcinoma in Syrian hamsters. Octreotide alone and the combined therapy (octreotide/tamoxifen) decreased the incidence of macroscopic pancreatic carcinomas as well as the number and size of liver metastases. The combined therapy showed no superior effect to octreotide alone. Furthermore, there was no difference between the tamoxifen and the control group.
Clinic of General, Visceral, Vascular and Thoracic Surgery, Charité Campus Mitte, Humboldt University of Berlin, Germany. Charipanc@aol.com
F A
FA
Wenger
M
M
Kilian
I
I
Mautsch
C A
CA
Jacobi
I
I
Schimke
G J
GJ
Saul
H
H
Guski
J M
JM
Müller
D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D002273:Carcinogens; D006224:Cricetinae; D015994:Incidence; D008113:Liver Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines; D015282:Octreotide / Q000494:pharmacology*; D010190:Pancreatic Neoplasms / Q000453:epidemiology / Q000378:metabolism / Q000473:pathology*; D011960:Receptors, Estrogen / Q000378:metabolism; D017481:Receptors, Somatostatin / Q000378:metabolism; D013629:Tamoxifen / Q000494:pharmacology*
D018931:Antineoplastic Agents, Hormonal; D002273:Carcinogens; D009602:Nitrosamines; D011960:Receptors, Estrogen; D017481:Receptors, Somatostatin; D013629:Tamoxifen; C013622:nitrosobis(2-oxopropyl)amine; D015282:Octreotide