Coenzyme Q10, vitamin E, and dihydrothioctic acid cooperatively prevent diene conjugation in isolated low-density lipoprotein.
Coenzyme Q (Q10) and alpha-tocopherol cooperatively delay the onset of diene conjugation in isolated human low density lipoprotein if supplied in water-soluble preparations to blood serum. Both copper ions and morpholino sydnonimine (in the presence of glucose; SIN-1-glucose) -driven diene conjugation is measurable as soon as both reduced Q10 and tocopherol are oxidized, where tocopherol oxidation starts after 80-90% consumption of reduced Q10. LDL-bound Q10 in turn can be rapidly reduced by dihydrolipoic acid (thioctic acid). This reaction is at least 10 times faster than reduction by ascorbic acid.
Schneider
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Institute of Phytopathology, Department of Applied Biochemistry, Technical University Munich, Freising-Weihenstephen, Germany.
Elstner
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EF
D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D003067:Coenzymes; D003300:Copper / Q000494:pharmacology; D006801:Humans; D007477:Ions / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D008981:Molsidomine / Q000031:analogs & derivatives / Q000494:pharmacology; D020030:Nitric Oxide Donors / Q000494:pharmacology; D010100:Oxygen / Q000378:metabolism; D011485:Protein Binding; D008063:Thioctic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D000975:Antioxidants; D003067:Coenzymes; D007477:Ions; D008077:Lipoproteins, LDL; D020030:Nitric Oxide Donors; D014451:Ubiquinone; D014810:Vitamin E; C002385:linsidomine; D008063:Thioctic Acid; D003300:Copper; C015144:dihydrolipoic acid; D008981:Molsidomine; C024989:coenzyme Q10; D001205:Ascorbic Acid; D010100:Oxygen