Adaptive physiological processes in the host during gastrointestinal parasitism.
Parasite infection of the gastrointestinal tract with helminths or protozoa induces detrimental effects on host tissues and host physiology, which have been extensively studied and reviewed. However, parasitism of the digestive system is also associated with adaptive, compensatory phenomena based on changes in host physiology or structures and which tend to counterbalance the negative consequences. The objective of this review is to describe these adaptive processes and their possible underlying mechanisms. Different processes which tend to attenuate the effect of either the loss of appetite, the intestinal malabsorption or the increased tissue losses have been assessed. These processes have been reported both for helminth and protozoan infections, where they present similar characteristics. The mechanisms involved in the adaptation to parasitism remain largely unidentified. The role of feedback mechanisms based on host regulation, possibly through gastrointestinal hormones, has been raised. On the other hand, some data support the proposal that parasites themselves may initiate some of the adaptive processes and consequently favour their own survival. These adaptive phenomena appear to be an essential component in the dynamic balance between host and parasites. Also, parasite infections represent unique models to study the adaptation of the gastrointestinal tract to aggressors.
Unité Mixte de Recherchesé 959, INRA/ENVT, 23 Chemin des Capelles Toulouse, F31076 Cedex, Toulouse, France. h.hoste@envt.fr
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D000222:Adaptation, Physiological; D000818:Animals; D004064:Digestive System / Q000469:parasitology*; D006373:Helminthiasis / Q000469:parasitology / Q000503:physiopathology*; D006790:Host-Parasite Interactions; D006801:Humans; D007411:Intestinal Diseases, Parasitic / Q000469:parasitology / Q000503:physiopathology*; D011528:Protozoan Infections / Q000469:parasitology / Q000503:physiopathology*