Gene therapy: recent progress in the clinical oncology arena.
Despite the rapid technological advances that continue to sustain the field of cancer gene therapy, few individual patients have benefited from the revolution so far. The plethora of clinical trials described confirms that each malignancy will have its own ideal strategy based on the associated molecular defects, and there has been rapid progress from this viewpoint. At the same time, there has been a renewed appreciation for the limitations to gene therapy, which include low efficiency of gene transfer, poor specificity of response and methods to accurately evaluate responses, and lack of truly tumor-specific targets at which to aim. As with all new therapies, we are climbing a steep learning curve in terms encountering treatment-related toxicities, as well as profound ethical and regulatory issues.
Department of Medical Oncology, St George's Hospital Medical School, Cranmer Terrace, London, SW17 ORE, UK. hpandha@sghms.ac.uk
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Pandha
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Martin
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Rigg
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Ross
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Dalgleish
D000818:Animals; D002986:Clinical Trials as Topic; D018390:Gene Targeting; D015316:Genetic Therapy / Q000379:methods / Q000639:trends*; D005822:Genetic Vectors; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000235:genetics; D015793:HLA-B7 Antigen / Q000235:genetics; D006801:Humans; D007167:Immunotherapy / Q000379:methods / Q000639:trends; D007371:Interferon-gamma / Q000235:genetics; D007376:Interleukin-2 / Q000235:genetics; D015847:Interleukin-4 / Q000235:genetics; D009369:Neoplasms / Q000628:therapy*; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000627:therapeutic use; D010957:Plasmids / Q000235:genetics; D011355:Prodrugs / Q000627:therapeutic use; D018139:Simplexvirus / Q000201:enzymology / Q000235:genetics; D013937:Thymidine Kinase / Q000235:genetics; D014161:Transduction, Genetic; D014780:Viruses / Q000472:pathogenicity
D015793:HLA-B7 Antigen; D007376:Interleukin-2; D016376:Oligonucleotides, Antisense; D011355:Prodrugs; D015847:Interleukin-4; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D013937:Thymidine Kinase