Both central command and exercise pressor reflex reset carotid sinus baroreflex.
In decerebrate unanesthetized cats, we determined whether either "central command," the exercise pressor reflex, or the muscle mechanoreceptor reflex reset the carotid baroreflex. Both carotid sinuses were vascularly isolated, and the carotid baroreceptors were stimulated with pulsatile pressure. Carotid baroreflex function curves were determined for aortic pressure, heart rate, and renal vascular conductance. Central command was evoked by electrical stimulation of the mesencephalic locomotor region (MLR) in cats that were paralyzed. The exercise pressor reflex was evoked by statically contracting the triceps surae muscles in cats that were not paralyzed. Likewise, the muscle mechanoreceptor reflex was evoked by stretching the calcaneal tendon in cats that were not paralyzed. We found that each of the three maneuvers shifted upward the linear relationship between carotid sinus pressure and aortic pressure and heart rate. Each of the maneuvers, however, had no effect on the slope of these baroreflex function curves. Our findings show that central command arising from the MLR as well as the exercise pressor reflex are capable of resetting the carotid baroreflex.
McIlveen
S A
SA
Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, California 95616, USA.
Hayes
S G
SG
Kaufman
M P
MP
D000818:Animals; D001013:Aorta, Thoracic / Q000294:innervation / Q000502:physiology*; D017704:Baroreflex / Q000502:physiology*; D001794:Blood Pressure; D017536:Carotid Artery, Common / Q000502:physiology*; D002342:Carotid Artery, External / Q000502:physiology*; D002346:Carotid Sinus / Q000502:physiology*; D002415:Cats; D004558:Electric Stimulation; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D007823:Laryngeal Nerves / Q000502:physiology; D008465:Mechanoreceptors / Q000502:physiology; D008636:Mesencephalon / Q000502:physiology*; D009043:Motor Activity; D009119:Muscle Contraction; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000502:physiology*; D010243:Paralysis; D005082:Physical Exertion / Q000502:physiology; D011311:Pressoreceptors / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology; D015656:Respiratory Mechanics