Artificial organs and vanishing boundaries.
With the first clinical use of the artificial kidney over 5 decades ago, we entered into a new era of medicine-that of substitutive and replacement therapy. Yet it took nearly another 15 years until chronic treatment was possible and nearly another 15 years until widespread treatment was possible due to government support. The history of development and clinical use of other artificial organ technologies such as the artificial heart and heart valves, the artificial lung, artificial blood, joint replacements, the artificial liver, the artificial pancreas, immunologic, metabolic, and neurologic support, neurocontrol, and tissue substitutes have followed similar long development paths. Despite their relatively long time to be put into clinical use, the contributions of artificial organ technologies to the betterment of mankind have been unquestionably a major success. For example, modern day surgery would not be possible without heart-lung support, and the technologies for heart support have led to the development of various minimally invasive technologies. The powerful impact that artificial organ technologies presently has on our lives is seen through the statistic that in the U.S.A. nearly 1 in 10 persons is living with an implanted medical device. With the aging of our population and the improvements in technologies, these numbers will only increase.
International Center for Artificial Organs and Transplantation, Painesville, Ohio 44077, USA.
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Malchesky
D000818:Animals; D001187:Artificial Organs / Q000191:economics / Q000592:standards / Q000639:trends*; D020811:Biomedical Technology; D003362:Cost-Benefit Analysis; D023281:Genomics; D006354:Heart, Artificial / Q000191:economics / Q000592:standards; D006801:Humans; D007688:Kidneys, Artificial / Q000191:economics / Q000592:standards; D019164:Liver, Artificial / Q000191:economics / Q000592:standards; D012371:Robotics; D016019:Survival Analysis; D016896:Treatment Outcome; D014481:United States; D014584:User-Computer Interface