Chromosome movement: dynein-out at the kinetochore.
Cell biologists have long speculated that a minus end-directed motor localized at kinetochores contributes to the poleward movement of chromosomes during mitosis. Two recent studies provide direct evidence that cytoplasmic dynein can perform this function.
Banks
J D
JD
Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3200, USA. jenbanks@uclink4.berkeley.edu
Heald
R
R
D000818:Animals; D016203:CDC2 Protein Kinase / Q000378:metabolism; D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone / Q000378:metabolism; D002875:Chromosomes / Q000502:physiology*; D019926:Cyclin B / Q000378:metabolism; D029721:Drosophila Proteins; D000072159:Dynactin Complex; D004398:Dyneins / Q000378:metabolism / Q000502:physiology*; D019476:Insect Proteins / Q000378:metabolism; D016547:Kinesins / Q000378:metabolism; D018386:Kinetochores / Q000378:metabolism / Q000502:physiology*; D008540:Meiosis / Q000502:physiology; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008938:Mitosis / Q000502:physiology*; D008941:Spindle Apparatus / Q000378:metabolism / Q000502:physiology; D029867:Xenopus Proteins
D018797:Cell Cycle Proteins; D002868:Chromosomal Proteins, Non-Histone; C503698:CycB protein, Drosophila; D019926:Cyclin B; D029721:Drosophila Proteins; D000072159:Dynactin Complex; D019476:Insect Proteins; C088335:KIF11 protein, Xenopus; C091489:KIF2C protein, human; D008869:Microtubule-Associated Proteins; D029867:Xenopus Proteins; C068688:centromere protein E; C076055:Zw10 protein, Drosophila; D016203:CDC2 Protein Kinase; D004398:Dyneins; D016547:Kinesins