Termination of early pregnancy in the scarred uterus with mifepristone and misoprostol.
OBJECTIVE
To analyze the safety and possibility of terminating early pregnancy up to 49 days gestation after cesarean section with mifepristone and misoprostol.


METHODS
One-hundred and ninety-two early pregnant women were recruited, of which, 35 cases with uterine cicatrix and 157 cases were no-uterine cicatrix as control group. All of them took 25 mg of mifepristone, b.i.d. for 3 days and 600 microg of misoprostol on the 4th day.


RESULTS
Of the 35 cases with uterine cicatrix, 33 achieved complete abortion after medical abortion. The complete abortion rate was 94.29% (95% CI 81-99%) in the cicatrix group and 89.81% (95% CI 75-91%) in the control group. There were no obvious complications detected in the cicatrix group.


CONCLUSIONS
For the termination of early pregnancy in scarred uterus, administration of mifepristone and misoprostol is safe and effective, and a further large series study needs be done to confirm its acceptability as a routine medication in such situations.
Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, PR China. jpxu@tjh.tjmu.edu.cn
J
J
Xu
H
H
Chen
T
T
Ma
X
X
Wu
D000019:Abortifacient Agents / Q000627:therapeutic use*; D000032:Abortion, Therapeutic / Q000379:methods*; D000328:Adult; D002585:Cesarean Section; D002921:Cicatrix; D005260:Female; D006801:Humans; D008875:Middle Aged; D015735:Mifepristone / Q000627:therapeutic use*; D016595:Misoprostol / Q000627:therapeutic use*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011446:Prospective Studies; D014599:Uterus
D000019:Abortifacient Agents; D016595:Misoprostol; D015735:Mifepristone