Male Paget's disease of the breast.
BACKGROUND
Paget's disease is an extremely rare condition of the male breast that presents as an eczematous change of the nipple and areola. It is almost always associated with an underlying intraductal carcinoma.


OBJECTIVE
A case of Paget's disease of the male breast with extension into adnexal structures is reported.


METHODS
A MEDLINE search for cases of Paget's disease of the male breast was performed and the cases were reviewed. The following antibodies were used in immunohistochemical staining: Rabbit Anti-Human c-erbB-2 Oncoprotein, monoclonal Mouse Anti-Human Estrogen Receptor (IgG1, kappa), and monoclonal Mouse Anti-Human Progesterone Receptor (Clone PgR 636).


RESULTS
This is only the 43rd histologically proven case of Paget's disease of the male breast in the world literature and, to our knowledge, the first to document extension of Paget's cells into adnexal structures, including eccrine glands.


CONCLUSIONS
Mammary Paget's disease is a rare phenomenon among men.
Faculty of Medicine, Dalhousie University, Canada.
Hayes R
Cummings B
Miller RA
Guha AK
D000368:Aged; D018567:Breast Neoplasms, Male / Q000473:pathology* / Q000601:surgery; D004439:Eccrine Glands / Q000473:pathology; D006801:Humans; D008297:Male; D010144:Paget's Disease, Mammary / Q000473:pathology* / Q000601:surgery