[Dynamics of mental disorders after extracerebral implantation of embryonal nervous tissue in epilepsy].
The paper presents the method elaborated by the authors for production, storage and implantation of embryonal nervous tissue (ENT). Extracerebral implantation was performed in 33 epileptic patients aged 2-58 years. Clinical state of the patients and EEG alterations were studied. Before treatment the patients' mental status was characterized by affective disorders, dysphoria, depression, exhaustion of mental processes, varying intellectual-mnestic decrease and behavioral disinhibition. Oligophrenia as of debility was observed in several cases. After implantation the pronounced positive changes in both paroxysmal states and overall mental status were observed in all the cases irrespective of their age of the patients. These clinical changes correlated with the dynamics of EEG changes (EEG changes were not observed in 2 individuals with positive clinical effects).
I M
IM
Akimova
F A
FA
Gurchin
L A
LA
Meliucheva
N Iu
NIu
Koroleva
A F
AF
Gurchin
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000196:embryology*; D016380:Brain Tissue Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000175:diagnosis; D015331:Cohort Studies; D004569:Electroencephalography; D004829:Epilepsy, Generalized / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000175:diagnosis* / Q000209:etiology*; D008875:Middle Aged; D012720:Severity of Illness Index