Role of T antigen interactions with p53 in tumorigenesis.
SV40 induces neoplastic transformation by disabling several key cellular growth regulatory circuits. Among these are the Rb- and p53-families of tumor suppressors. The multifunctional, virus-encoded large T antigen blocks the function of both Rb and p53. Large T antigen uses multiple mechanisms to block p53 activity, and this action contributes to tumorigenesis, in part, by blocking p53-mediated growth suppression and apoptosis. Since the p53 pathway is inactivated in most human tumors, T antigen/p53 interactions offer a possible mechanism by which SV40 contributes to human cancer.
Department of Biological Sciences, University of Pittsburgh, Pittsburgh, PA 15260, USA.
J M
JM
Pipas
A J
AJ
Levine
D000818:Animals; D000952:Antigens, Polyomavirus Transforming / Q000502:physiology*; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D004263:DNA Tumor Viruses / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000378:metabolism*; D011485:Protein Binding; D016160:Retinoblastoma Protein / Q000235:genetics / Q000378:metabolism*; D015533:Transcriptional Activation; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
D000952:Antigens, Polyomavirus Transforming; D016160:Retinoblastoma Protein; D016159:Tumor Suppressor Protein p53