Synthesis and preliminary antimicrobial screening of new benzimidazole heterocycles.
A series of 2-methylbenzimidazole incorporated to different heterocycles through ethyl or carbamoylethyl groups at position 1 of benzimidazole were synthesized. Also 3-(2-methylbenzimidazol-1-yl)propanoic acid hydrazide incorporated with semicarbazides and thiosemicarbazides were prepared. Moreover, the triazole 5e underwent Michael addition and alkylation reaction. Some of the newly synthesized compounds showed considerable antimicrobial activity against gram positive, negative bacteria and yeast.
Therapeutical Chemistry Dept., National Research Centre, Dokki, Cairo, Egypt. hh_fahmy@usa.net
H H
HH
Fahmy
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A
El-masry
S H
SH
Ali Abdelwahed
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001562:Benzimidazoles; D006571:Heterocyclic Compounds