Thymic malignancies.
Thymomas and thymic carcinomas are unique tumors of the anterior mediastinum. The association of a variety of different paraneoplastic syndromes with such lesions has fascinated physicians and researchers for years. Most recently, it has been demonstrated by numerous authors that thymomas are chemosensitive tumors. Their indolent nature and relative rarity have made evaluation through prospective randomized clinical trials extremely difficult. Further information regarding the molecular nature of these neoplasms and immunologic aspects is needed in future investigation.
Indiana University School of Medicine, Indianapolis, IN 46202, USA.
P J
PJ
Loehrer
M R
MR
Wick
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000361:Agammaglobulinemia / Q000209:etiology; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001327:Autoimmune Diseases / Q000209:etiology; D002277:Carcinoma / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D002945:Cisplatin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004847:Epithelial Cells / Q000473:pathology; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use; D007155:Immunologic Factors / Q000627:therapeutic use; D007376:Interleukin-2 / Q000627:therapeutic use; D015337:Multicenter Studies as Topic; D009157:Myasthenia Gravis / Q000209:etiology; D009367:Neoplasm Staging; D016609:Neoplasms, Second Primary; D010257:Paraneoplastic Syndromes / Q000209:etiology; D018714:Radiotherapy, Adjuvant; D012010:Red-Cell Aplasia, Pure / Q000209:etiology; D013934:Thymectomy; D013945:Thymoma / Q000145:classification / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D013950:Thymus Gland / Q000166:cytology / Q000196:embryology; D013953:Thymus Neoplasms / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology / Q000628:therapy; D016896:Treatment Outcome
D000305:Adrenal Cortex Hormones; D000970:Antineoplastic Agents; D007155:Immunologic Factors; D007376:Interleukin-2; D002945:Cisplatin; D007069:Ifosfamide