Celiac disease.
Celiac disease is more prevalent than it was previously thought to be, and screening of selected population groups may reveal many new cases. Tissue transglutaminase appears to have a significant role in the degradation of gliadin and antigen production. Specific gliadin epitopes have been defined using T-cell responses. Bone disease is a significant problem for patients with celiac disease but management guidelines are being developed. Refractory sprue (nonresponsive celiac disease) appears to be a manifestation of enteropathy-associated T-cell lymphoma in most cases.
Academic Unit of General Surgery, Medicine, and Anesthesia, St. James' University Hospital, Leeds, UK.
Jason S.R.
JS
Jennings
Peter D.
PD
Howdle