Prevalence and degree of expression of the carbapenemase gene (cfiA) among clinical isolates of Bacteroides fragilis in Nottingham, UK.
The carbapenemase gene (cfiA) was detected in 12 (6.9%) out of 175 clinical isolates of Bacteroides fragilis from Nottingham, three times the frequency reported from France. Only one gene copy was present in all cases. Eleven (6.3%) of the cfiA-positive isolates were susceptible to imipenem or meropenem (MIC < 8 mg/L); strains of this type have the potential to convert to high-level resistance. One isolate (0.6%) displayed resistance to both carbapenem antibiotics and was associated with specific carbapenemase activity six times that of the sensitive isolates.
Division of Microbiology and PHLS Laboratory, University Hospital, Queen's Medical Centre, Nottingham NG7 2UH, UK. richard.edwards@nottingham.ac.uk
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R
Edwards
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Hawkyard
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Garvey
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Greenwood
D001426:Bacterial Proteins; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000235:genetics*; D004352:Drug Resistance, Microbial / Q000502:physiology; D018628:Gene Dosage; D015964:Gene Expression Regulation, Bacterial; D015378:Imipenem / Q000494:pharmacology; D000077731:Meropenem; D008826:Microbial Sensitivity Tests; D013845:Thienamycins / Q000494:pharmacology; D006113:United Kingdom; D001618:beta-Lactamases / Q000235:genetics*
D001426:Bacterial Proteins; D013845:Thienamycins; D015378:Imipenem; D001618:beta-Lactamases; C063912:carbapenemase; D000077731:Meropenem