[Effectiveness of an improved antiseptic in treatment of contaminated soft tissue wounds].
A novel antiseptic biguanide has been shown to be more bactericidal and tissue compatible in vitro than other antiseptics. In our controlled, prospective and randomized double-blind study on patients with bacteria-contaminated wound types 2-4, one group (n = 45) was treated with humid cotton swab dressings of 0.2% Lavasept solution compared with Ringer solution (n = 35). No deterioration of wound healing was observed in either group. Lavasept treatment resulted in faster and significant reduction of gram-positive germs. The tissue compatibility of Lavasept was evaluated as significantly better than Ringer solution.
Abteilung für Unfallchirurgie, Universitätsklinikum GHS Essen.
K P
KP
Schmit-Neuerburg
C
C
Bettag
W
W
Schlickewei
W
W
Fabry
J
J
Hanke
K
K
Renzing-Köhler
H
H
Hirche
H J
HJ
Kock
D000328:Adult; D000368:Aged; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage* / Q000009:adverse effects; D001424:Bacterial Infections / Q000188:drug therapy*; D001645:Biguanides; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013530:Surgical Wound Infection / Q000188:drug therapy*; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000188:drug therapy*
D000891:Anti-Infective Agents, Local; D001645:Biguanides