Isolated diffuse mesangial sclerosis and Wilms tumor suppressor gene.
Diffuse mesangial sclerosis is a rare renal disease, occurring either in isolation or as part of Denys-Drash syndrome. Denys-Drash syndrome originates from mutations of the Wilms tumor suppressor gene (WT1 ). We describe the presence of WT1 mutations in 7 Japanese children with isolated diffuse mesangial sclerosis.
Ito
S
S
Department of Nephrology, Tokyo Metropolitan Kiyose Children's Hospital, Tokyo, Japan.
Takata
A
A
Hataya
H
H
Ikeda
M
M
Kikuchi
H
H
Hata
J
J
Honda
M
M
D005260:Female; D016162:Genes, Wilms Tumor / Q000235:genetics*; D005920:Glomerular Mesangium / Q000473:pathology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D007674:Kidney Diseases / Q000235:genetics* / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D017354:Point Mutation; D012598:Sclerosis