Lbx1 marks a subset of interneurons in chick hindbrain and spinal cord.
The putative transcription factor Lbx1 is expressed in the mantle zone of the hindbrain and spinal cord caudal to rhombomere 1, in a specific domain of the alar plate. The Lbx1 domain overlaps with the expression domains for Tlx3 and partially with the domains for Pax2/Lim1. The ventral border of the Lbx1 domain coincides with the ventral border of the dorsalmost Serrate1 stripe in the ventricular zone. The latter borders the intermediate stripe of both Delta and Lunatic fringe expression. The Lbx1 domain contains differentiated interneurons that project into the lateral longitudinal fasciculus.
MRC Centre for Developmental Neurobiology, King's College London, 4th Floor New Hunt's House, Guy's Campus, SE1 9RT, London, UK. frank.schubert@kcl.ac.uk
F R
FR
Schubert
S
S
Dietrich
R C
RC
Mootoosamy
S C
SC
Chapman
A
A
Lumsden
D000818:Animals; D030161:Avian Proteins; D001369:Axons / Q000378:metabolism; D001921:Brain / Q000196:embryology; D002135:Calcium-Binding Proteins; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000096:biosynthesis; D004625:Embryo, Nonmammalian / Q000378:metabolism; D016695:Glycosyltransferases; D018398:Homeodomain Proteins / Q000096:biosynthesis; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; D060850:LIM-Homeodomain Proteins; D008565:Membrane Proteins / Q000096:biosynthesis; D009124:Muscle Proteins / Q000096:biosynthesis* / Q000235:genetics; D009419:Nerve Tissue Proteins; D009474:Neurons / Q000378:metabolism; D015513:Oncogene Proteins / Q000096:biosynthesis; D051762:PAX2 Transcription Factor; D014176:Protein Biosynthesis; D017434:Protein Structure, Tertiary; D011506:Proteins; D012249:Rhombencephalon / Q000196:embryology*; D000072099:Serrate-Jagged Proteins; D013116:Spinal Cord / Q000196:embryology*; D013997:Time Factors; D014018:Tissue Distribution; D014157:Transcription Factors / Q000096:biosynthesis; D029867:Xenopus Proteins
D030161:Avian Proteins; D002135:Calcium-Binding Proteins; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D036341:Intercellular Signaling Peptides and Proteins; D047908:Intracellular Signaling Peptides and Proteins; D000072100:Jagged-1 Protein; C113279:LBX1 protein, Gallus gallus; D060850:LIM-Homeodomain Proteins; D008565:Membrane Proteins; D009124:Muscle Proteins; D009419:Nerve Tissue Proteins; D015513:Oncogene Proteins; D051762:PAX2 Transcription Factor; D011506:Proteins; D000072099:Serrate-Jagged Proteins; D014157:Transcription Factors; D029867:Xenopus Proteins; C064045:delta protein; C063843:insulin gene enhancer binding protein Isl-1; C000606280:jag1 protein, Xenopus; C489501:tlx1 protein, Xenopus; D016695:Glycosyltransferases; C498394:LFNG protein, Gallus gallus