Possible mechanism by which allyl sulfides suppress neoplastic cell proliferation.
Both oil- and water-soluble allyl sulfur compounds from garlic have been found to possess antitumorigenic properties. These antitumorigenic properties increase as exposure increases both in vitro and in vivo. Generally, oil-soluble allyl sulfur compounds are more effective antiproliferative agents than their water-soluble counterparts. The ability of these compounds to suppress proliferation is associated with a depression in cell cycle progression and the induction of apoptosis. This depression in cell division coincides with an increase in the percentage of cells blocked in the G(2)/M phase of the cell cycle. A depression in p34(cdc2) kinase may account for this blockage in cell division.
Graduate Program in Nutrition and the Nutrition Department, The Pennsylvania State University, University Park, PA 16802, USA.
L M
LM
Knowles
J A
JA
Milner
D000498:Allyl Compounds / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D018844:Cyclin-Dependent Kinases; D005737:Garlic / Q000737:chemistry*; D009369:Neoplasms / Q000201:enzymology / Q000473:pathology*; D010946:Plants, Medicinal; D017346:Protein Serine-Threonine Kinases / Q000187:drug effects / Q000378:metabolism; D013440:Sulfides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000201:enzymology; D000095043:Cyclin-Dependent Kinase-Activating Kinase
D000498:Allyl Compounds; D000970:Antineoplastic Agents; D013440:Sulfides; C038491:allyl sulfide; D017346:Protein Serine-Threonine Kinases; D018844:Cyclin-Dependent Kinases; D000095043:Cyclin-Dependent Kinase-Activating Kinase