[Morphometric study on the effects of estrone on bone in vitro].
OBJECTIVE
To study the effects of estrone on the bone resorption and bone formation in vitro.


METHODS
Long bones from 16-day-old female mouse fetuses were cultured in BGJb medium for 48 h. The bones were harvested, then bones length and length of their diaphyses were measured under stereo microscope. The histomorphormetric analyses on midlongitudinal sections of bones were performed. The numbers of osteoclasts and hypertrophic chondrocytes were observed under biological microscope.


RESULTS
Compared with control, there were significant increase in bones length and length of their diaphyses after treated with 10(-7) mol/L estrone. Under this condition, decreased osteoclasts and increased hypertrophic chondrocytes were observed, too.


CONCLUSIONS
Estrone stimulates bone formation and inhibites bone resorption in vitro.
Li
L Z
LZ
Department of Pharmacology, Medical College of Chinese People's Armed Police Forces, Tianjin 300162.
Zhang
Y L
YL
Ma
L Y
LY
Feng
K L
KL
D000818:Animals; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects*; D004970:Estrone / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010012:Osteogenesis / Q000187:drug effects*
D004970:Estrone