[Effect of pineal peptide on parameters of the biological age and life span in mice].
Female CBA mice were injected with s.c. synthetic tetrapeptide Epithalon from a 6-month age until death. The drug failed to affect the body weight or food consumption, physical activity or behavioural parameters. However, it slowed down the age-related switching off of the estrus function, decreased body temperature, decelerated free redical processes, prolonged the mice life span with an accompanying drop in spontaneous tumour incidence.
Anisimov
V N
VN
Institute of Oncology, 189646, St. Petersburg, Pesochny-2, Russia.
Khavinson
V Kh
VKh
Zavarzina
N Iu
NIu
Zabezhinskiĭ
M A
MA
Zimina
O A
OA
Popovich
I G
IG
Shtylik
A V
AV
Arutiunian
A V
AV
Oparina
T I
TI
Prokopenko
V M
VM
D000375:Aging / Q000502:physiology*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D004971:Estrus / Q000187:drug effects; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D008136:Longevity / Q000187:drug effects*; D051379:Mice; D008808:Mice, Inbred CBA; D009043:Motor Activity / Q000187:drug effects; D018763:Muscle Fatigue / Q000187:drug effects; D009369:Neoplasms / Q000517:prevention & control; D009842:Oligopeptides / Q000494:pharmacology*; D012098:Reproduction / Q000187:drug effects
D005609:Free Radicals; D009842:Oligopeptides; C421253:alanyl-glutamyl-aspartyl-glycine