Semi-synthesis of 2-deoxo- and 3-epi-paraherquamide A.
2-Deoxo- and 3-epi-paraherquamide A were synthesized from paraherquamide A. 2-Deoxoparaherquamide A has good activity against HC and TC in our jird model comparable to the parent compound, while 3-epi-paraherquamide A showed no activity.
Lee
B H
BH
Animal Health Discovery Research, Pharmacia Corp., Kalamazoo, MI 49001, USA. bhlee@am.pnu.com
Clothier
M F
MF
Johnson
S S
SS
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000494:pharmacology; D005849:Gerbillinae; D007212:Indolizines / Q000138:chemical synthesis* / Q000494:pharmacology; D013141:Spiro Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D007212:Indolizines; D013141:Spiro Compounds; C063985:paraherquamide