Calcium supplements interact significantly with long-term diet while suppressing rectal epithelial proliferation of adenoma patients.
BACKGROUND
Calcium supplements to the western-style diet may reduce the risk for colorectal neoplasia. Using rectal epithelial proliferation (REP) measurements as a biomarker of response to intervention, the authors evaluated the effects of 1-year calcium supplementation in adenoma patients and its possible interactions with the patients' dietary and lifestyle habits.


METHODS
Consenting adenoma patients, without a family history of colorectal neoplasia, were randomly selected to receive 3.75 g calcium carbonate (1.5 g Ca2+) daily or to receive no treatment. All had their long-term dietary and lifestyle habits assessed and their REP labeling index (LI) evaluated before and at end of follow-up. The change in LI was compared between groups, and statistical associations were examined between mean nutrient consumption and treatment effect and between lifestyle and treatment effect.


RESULTS
Fifty-two adenoma patients (33 treated and 19 untreated) completed intervention and follow-up. There were no significant differences between study groups in age, weight, cigarette smoking, or medication use. The LI decreased in 58% of calcium-intervened patients and in only 26% of nonintervened patients (P = 0.04); the mean LI x 100 (+/- standard deviation) of the former fell from 5.04 +/- 1.93 to 4.54 +/- 1.58, and rose from 4.32 +/- 1.58 to 4.93 +/- 1.58 in the latter (P = 0.04). A lower fat, a higher carbohydrate, fiber, or fluid intake each interacted with the calcium supplementation to decrease the LI (P = 0.02, 0.001, 0.02, and 0.08, respectively).


CONCLUSIONS
Long-term calcium supplements significantly suppressed REP in adenoma patients, and long-term dietary habits contributed to this effect. Patient diet should be assessed when researchers use REP as a biomarker in calcium chemoprevention studies. Study results indicated that relevant dietary counseling may be useful in addition to calcium supplements in persons at increased risk for colorectal neoplasia.
Department of Gastroenterology, Tel Aviv Medical Center, 6 Weizmann Street, Tel Aviv 64239 Israel. rozen@tasmc.health.gov.il
P
P
Rozen
F
F
Lubin
N
N
Papo
J
J
Knaani
H
H
Farbstein
M
M
Farbstein
G
G
Zajicek
D000236:Adenoma / Q000473:pathology / Q000517:prevention & control*; D000328:Adult; D000368:Aged; D001706:Biopsy; D002119:Calcium Carbonate / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D018890:Chemoprevention; D015179:Colorectal Neoplasms / Q000473:pathology / Q000517:prevention & control*; D004032:Diet; D019587:Dietary Supplements; D004847:Epithelial Cells / Q000187:drug effects*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008019:Life Style; D008297:Male; D008875:Middle Aged; D012007:Rectum / Q000473:pathology
D002119:Calcium Carbonate