Expression of human MxA protein in mosquito cells interferes with LaCrosse virus replication.
Human MxA protein inhibits LaCrosse virus (LAC virus; family Bunyaviridae) replication in vertebrate cells and MxA-transgenic mice. LAC virus is transmitted to humans by Aedes triseriatus mosquitoes. In this report, we have shown that transfected mosquito cells expressing the human MxA cDNA are resistant to LAC virus but permissive for Sindbis virus (family Togaviridae) infection.
Arthropod-Borne and Infectious Diseases Laboratory, Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523 USA.
T A
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Miura
J O
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Carlson
B J
BJ
Beaty
R A
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Bowen
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Olson
D000330:Aedes / Q000166:cytology / Q000235:genetics / Q000821:virology*; D000818:Animals; D000998:Antiviral Agents / Q000235:genetics / Q000378:metabolism*; D002478:Cells, Cultured; D019204:GTP-Binding Proteins; D006801:Humans; D018062:La Crosse virus / Q000502:physiology*; D064547:Myxovirus Resistance Proteins; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D012845:Sindbis Virus / Q000502:physiology; D014162:Transfection; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; C579071:MX1 protein, human; D064547:Myxovirus Resistance Proteins; D011506:Proteins; D019204:GTP-Binding Proteins