Tissue factor, the blood, and the arterial wall.
Thrombogenic tissue factor (TF) on cell-derived microparticles is present in the circulating blood of patients with acute coronary syndromes. Recently, we reported that leukocytes transfer TF-positive particles to platelet thrombi, making them capable of triggering and propagating thrombus growth. This observation changes the original dogma that vessel-wall injury and exposure of tissue factor within the vasculature to blood is sufficient for the occurrence of arterial thrombosis. The transfer of TF-positive leukocyte particles is dependent on the interaction of CD15 and TF with platelet thrombi. The inhibition of TF transfer and TF activity suggests a novel therapeutic approach to the prevention of thrombosis that may prove to be effective in disorders associated with increased blood TF.
Division of Thrombosis Research, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA.
U
U
Rauch
Y
Y
Nemerson
D003326:Coronary Circulation / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology; D003331:Coronary Vessels / Q000503:physiopathology*; D006801:Humans; D013925:Thromboplastin / Q000378:metabolism* / Q000502:physiology*; D013927:Thrombosis / Q000097:blood* / Q000503:physiopathology*
D013925:Thromboplastin