Differential impact of the FMR-1 full mutation on memory and attention functioning : a neuropsychological perspective.
Memory and attention processing were examined in a group of 15 adult Fragile-X syndrome (FXS) males with Fragile-X mental retardation 1 (FMR-1) full mutation and compared to two control groups: a learning disabled (LD) control and a normal functioning control. Performance was assessed across a wide range of tasks including working memory, recognition memory, selective attention, sustained attention, and attentional switching. All three groups performed at a comparable level on recognition memory tasks, and the Fragile-X males and LD control group performed worse than the control group on tasks of working memory and sustained attention. On a task of executive function, the Fragile-X males demonstrated a significant deficit in comparison to the LD control group and the normal control group, but performed better than the LD control group and at a comparable level to the control group on tasks of selective attention. Molecular analyses of the lymphocyte DNA provided little evidence for a correlation between expansion size and performance on tasks of memory and attention. The findings from the present study are discussed in the context of functional neuroimaging and brain-behavior-molecular correlates.
Section of Developmental Psychiatry, Division of Psychiatry, Queens Medical Centre, University of Nottingham, UK.
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Cornish
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Munir
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Cross
D000328:Adult; D001288:Attention / Q000502:physiology*; D003071:Cognition / Q000502:physiology; D005145:Face; D051860:Fragile X Messenger Ribonucleoprotein 1; D005600:Fragile X Syndrome / Q000235:genetics / Q000523:psychology*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics / Q000523:psychology*; D007859:Learning Disabilities / Q000523:psychology; D008297:Male; D008568:Memory / Q000502:physiology*; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009483:Neuropsychological Tests; D010364:Pattern Recognition, Visual / Q000502:physiology; D016601:RNA-Binding Proteins
D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human