Analysis of the p53 gene in parotid gland cancers: a relatively high frequency of mutations in low-grade mucoepidermoid carcinomas.
Mutations and overexpression of the p53 gene and protein were analyzed in 40 cases with various types of parotid gland cancers. Mutations were found in 12 cases (30%), and low-grade mucoepidermoid carcinomas (43%) and highly malignant carcinomas including adenocarcinoma, salivary duct carcinoma, and undifferentiated carcinoma (56%) showed a relatively high frequency of mutations. Overexpression of the protein was observed in 11 cases (28%) and 4 of the 11 cases also had p53 mutations. These results suggest that mutations of the p53 gene have significance in certain types of parotid cancers irrespective of the aggressiveness of a tumor type.
Department of Otorhinolaryngology, Chiba University, School of Medicine 1-8-1 Inohana, Chuoh-ku, Chiba 260-8670, Japan. 97md0540@insei.m.chiba-u.ac.jp
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Mutoh
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Nagata
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Ohno
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Numata
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Nagao
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Konno
D018277:Carcinoma, Mucoepidermoid / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis; D004277:DNA, Single-Stranded; D005260:Female; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007124:Immunoenzyme Techniques; D009154:Mutation; D009690:Nucleic Acid Conformation; D010307:Parotid Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D018807:Polymorphism, Single-Stranded Conformational
D004273:DNA, Neoplasm; D004277:DNA, Single-Stranded