Development of a novel screen for protease inhibitors.
We have developed a novel plasmid-based, quantitative, in vitro screen to test the protease-inhibiting activities of existing and newly discovered agents.
Divisions of Infectious Disease and Nephrology, Mount Sinai School of Medicine, 1 Gustave L. Levy Place, New York, NY 10029-6874, USA.
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Gillim
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Gusella
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Vargas
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Marras
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Klotman
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Cara
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D017930:Genes, Reporter; D016333:HIV Protease / Q000235:genetics*; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D008156:Luciferases; D010957:Plasmids; D014162:Transfection
D017320:HIV Protease Inhibitors; D008156:Luciferases; D016333:HIV Protease