Orientia tsutsugamushi infection: overview and immune responses.
Orientia tsutsugamushi, an obligate intracellular bacterium, was isolated for the first time in 1930. Infections by virulent strains are characterized by fever, rash, eschar, pneumonia, myocarditis, and disseminated intravascular coagulation. Here we review the general aspects of O. tsutsugamushi and immune responses in terms of inflammation, protective immune mechanisms, and immunogenic antigens.
Department of Microbiology and Immunology, Seoul National University College of Medicine and Institute of Endemic Disease, Seoul National University Medical Research Center, 28 Yongon-dong, Chongno-gu, 110-799, Seoul, South Korea.
S Y
SY
Seong
M S
MS
Choi
I S
IS
Kim
D000818:Animals; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology; D001315:Australia; D016207:Cytokines / Q000096:biosynthesis; D006801:Humans; D007111:Immunity, Cellular; D007249:Inflammation / Q000276:immunology; D007564:Japan; D012285:Orientia tsutsugamushi / Q000276:immunology* / Q000648:ultrastructure; D010154:Pakistan; D012426:Russia; D012612:Scrub Typhus / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology
D000942:Antigens, Bacterial; D016207:Cytokines