Phosgene exposure: mechanisms of injury and treatment strategies.
Phosgene (carbonyl chloride, CAS 75-44-5) is a highly reactive gas of historical interest and current industrial importance. Phosgene has also proved to be a useful model for the study of those biochemical mechanisms that lead to permeability-type pulmonary edema (adult respiratory distress syndrome). In turn, the study of phosgene-induced adult respiratory distress syndrome has provided insights leading to revised treatment strategies for exposure victims. We summarized recent findings on the mechanisms of phosgene-induced pulmonary edema and their implications for victim management. In light of that research, we also provide a comprehensive approach to the management and treatment of phosgene exposure victims.
Borak
J
J
Yale University, New Haven, Conn., USA. jborak@jborak.com
Diller
W F
WF
D000328:Adult; D004781:Environmental Exposure; D006801:Humans; D010705:Phosgene / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000503:physiopathology* / Q000628:therapy; D012128:Respiratory Distress Syndrome / Q000503:physiopathology; D014218:Triage
D010705:Phosgene