Lithium-induced nephrogenic diabetes insipidus.
Two patients with severe lithium-induced nephrogenic diabetes insipidus are described. Although it is known lithium can cause diabetes insipidus, one should be especially alert in psychiatric patients, as the main defence mechanisms thirst and drinking behaviour may not function adequately in these patients. The major form of therapy in both patients consisted of drinking, a thiazide diuretic, as well as a protein and sodium restricted diet.
Eustatia-Rutten
C F
CF
Department of General Internal Medicine, LUMC, C1-R, P.O. Box 9600, 2300 RC, Leiden, The Netherlands. rutten_int@hotmail.com
Tamsma
J T
JT
Meinders
A E
AE
D000368:Aged; D018692:Antimanic Agents / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy; D018500:Diabetes Insipidus, Nephrogenic / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D003937:Diagnosis, Differential; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D016651:Lithium Carbonate / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D018692:Antimanic Agents; D016651:Lithium Carbonate