[Interactive determination of the parameters of mathematical models in planning radiotherapy of malignant tumors. 3. Method of local adjustment of the parameters of mathematical models (examples of application)].
To increase the accuracy of calculation of tolerance doses of the likelihood of radiation-induced complications in normal organs and tissues by using mathematical models, the author has developed a method for local mathematical model parameter adjustment (LMMPA) which included analysis of the structure of a mathematical model, systematization of clinical information and its goal-oriented use to determine the parameters of a model. The necessity of developing the LMMPA method stemmed from the complexity of the body exposed to radiation a system and from the quest for taking into account the impact of the system on the values of mathematical models. LMMPA may be regarded as the extension of determination of the parameters of mathematical models or as the interactive determination of their parameters that describing radiation exposures of complex biological systems. Different aspects of using of LMMPA are indicated how to apply it to the determination of tolerance doses for connective tissue, lung tissue, and the brain by using the Ellis and LQ models. The extended LMMPA is shown how to determine the parameters of a mathematical models for calculation of the likelihood of radiation-induced complications in the lung tissue.
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D001921:Brain / Q000528:radiation effects; D003238:Connective Tissue / Q000528:radiation effects; D006801:Humans; D008168:Lung / Q000528:radiation effects; D008962:Models, Theoretical; D009369:Neoplasms / Q000532:radiotherapy*; D011829:Radiation Dosage; D011836:Radiation Tolerance; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted