Regulation of interleukin-12 production by G-protein-coupled receptors.
G-protein-coupled receptors have long been known to play a critical role in the recruitment and migration of leukocytes to areas of inflammation. This review will focus, however, on emerging data that G-protein-coupled receptors can modulate cytokine production by antigen-presenting cells including interleukin-12 and tumor necrosis factor-alpha and may therefore play a significant role in the regulation of innate and acquired immunity.
Immune Cell Interaction Unit, Mucosal Immunity Section, Laboratory of Clinical Investigation, NIAID, NIH, Bldg. 10, 11-N-238, 10 Center Drive Bethesda, MD 20892, USA.
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MC
Braun
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Kelsall
D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D003713:Dendritic Cells / Q000276:immunology / Q000378:metabolism; D005786:Gene Expression Regulation; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis* / Q000235:genetics; D051379:Mice; D009000:Monocytes / Q000276:immunology / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction
D011956:Receptors, Cell Surface; D018664:Interleukin-12; D000242:Cyclic AMP; D020962:Heterotrimeric GTP-Binding Proteins