Safety and efficacy of pallidal or subthalamic nucleus stimulation in advanced PD.
The authors retrospectively compared 1-year results of bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN; n = 16) and internal pallidum (GPi) (n = 11) in advanced PD and found about equal improvements in "off" period motor symptoms, dyskinesias, and fluctuations. STN stimulation reduced medication requirements by 65% and required significantly less electrical power. These advantages contrasted with a need for more intensive postoperative monitoring and a higher incidence of adverse events related to levodopa withdrawal.
Department of Neurology, Heinrich-Heine-University, Düsseldorf, Germany. volkmann@neurologie.uni-duesseldorf.de
J
J
Volkmann
N
N
Allert
J
J
Voges
P H
PH
Weiss
H J
HJ
Freund
V
V
Sturm
D000203:Activities of Daily Living; D000368:Aged; D004558:Electric Stimulation / Q000009:adverse effects*; D005917:Globus Pallidus / Q000503:physiopathology*; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D012189:Retrospective Studies; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D013997:Time Factors
D007980:Levodopa