Chlamydia pneumoniae in children undergoing adenoidectomy.
Chlamydia pneumoniae is a common respiratory pathogen which is often found in paediatric populations. Little is known about the true colonization rate and the localization of the bacteria in the respiratory tract. In this study, immunohistochemistry was used to examine adenoids from 69 children undergoing elective adenoidectomy. Throat swabs for polymerase chain reaction (PCR) and blood samples for serology were also obtained. Chlamydia pneumoniae was demonstrated in the adenoids by immunohistochemistry in 68 of the children. Five children (7%) had a positive C. pneumoniae PCR test from throat swabs and 14 children (20%) had detectable antibodies by the microimmunofluorescence technique.


CONCLUSIONS
The results suggest that C. pneumoniae is a common finding in the adenoids of children undergoing adenoidectomy. Whether or not C. pneumoniae plays a pathogenic role in this patient population could not be determined from the data obtained in this investigation.
Normann
E
E
Department of Paediatrics, Central Hospital, Gävle, Sweden. erik.normann@lg.se
Gnarpe
J
J
Nääs
J
J
Gnarpe
H
H
Karlsson
M G
MG
Wettergren
B
B
D000233:Adenoidectomy / Q000379:methods*; D000234:Adenoids / Q000276:immunology / Q000382:microbiology* / Q000601:surgery*; D000293:Adolescent; D000911:Antibodies, Monoclonal / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002690:Chlamydia Infections / Q000276:immunology / Q000382:microbiology*; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction
D000911:Antibodies, Monoclonal