Comparison of three rat strains for development of radiation-induced lung injury after hemithoracic irradiation.
The purpose of this study is to define differences in radiation sensitivity among rat strains using breathing frequency and lung perfusion as end points of radiation-induced lung injury. The results have confirmed previous findings in mice showing that under stringently controlled iso-dose/volume irradiation conditions, substantial differences can be found in susceptibility to functional lung damage after radiation.
van Eerde
M R
MR
Department of Radiotherapy, University Hospital Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands.
Kampinga
H H
HH
Szabo
B G
BG
Vujaskovic
Z
Z
D000818:Animals; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D008168:Lung / Q000000981:diagnostic imaging / Q000528:radiation effects*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011652:Pulmonary Circulation / Q000528:radiation effects; D011829:Radiation Dosage; D011832:Radiation Injuries / Q000000981:diagnostic imaging / Q000503:physiopathology; D011836:Radiation Tolerance; D011877:Radionuclide Imaging; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar; D012119:Respiration / Q000528:radiation effects