Prevalence and relation to risk factors of carotid atherosclerosis and left ventricular hypertrophy in systemic lupus erythematosus and antiphospholipid antibody syndrome.
The prevalence of preclinical cardiovascular disease was determined in women with systemic lupus erythematosus (SLE) and control subjects matched for traditional risk factors. Compared with control subjects, patients with SLE had a higher prevalence of carotid atherosclerosis (41% vs 9%, p < 0.005) and left ventricular hypertrophy (32% vs 5%, p < 0.005), supporting the possibility that chronic inflammation predisposes to premature cardiovascular disease in SLE.
Roman
M J
MJ
Division of Cardiology, The New York Presbyterian Hospital-Weill Cornell Medical Center, New York, USA. mroman@med.cornell.edu
Salmon
J E
JE
Sobel
R
R
Lockshin
M D
MD
Sammaritano
L
L
Schwartz
J E
JE
Devereux
R B
RB
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000453:epidemiology; D001161:Arteriosclerosis / Q000175:diagnosis* / Q000453:epidemiology; D016893:Carotid Stenosis / Q000175:diagnosis* / Q000453:epidemiology; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000453:epidemiology; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000453:epidemiology; D008875:Middle Aged; D009864:Ontario; D010865:Pilot Projects; D012306:Risk