Can sequencing shed light on cell cycling?
Every organism must have cells that can replicate indefinitely. Can the draft human genome sequence tell us how the cell cycle works and how it evolved? We studied two protein families--the cyclins and their partners the cyclin-dependent kinases (Cdks)--and a conserved regulatory circuit, the spindle checkpoint. Disappointingly, we discovered a few novel cyclins and no new Cdks or components of the spindle checkpoint, and could shed little light on the organization of the cell cycle.
Center for Genomics Research, Harvard University, Cambridge, Massachusetts 02138, USA. amurray@mcb.harvard.edu
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D000595:Amino Acid Sequence; D000818:Animals; D002453:Cell Cycle / Q000235:genetics*; D018844:Cyclin-Dependent Kinases / Q000235:genetics*; D016213:Cyclins / Q000235:genetics*; D018816:Genes, cdc; D015894:Genome, Human; D016045:Human Genome Project; D006801:Humans; D008969:Molecular Sequence Data; D016415:Sequence Alignment; D008941:Spindle Apparatus / Q000235:genetics
D016213:Cyclins; D018844:Cyclin-Dependent Kinases