Molecular mechanism of transcriptional control by nuclear vitamin receptors.
Nuclear receptors for vitamins A and D belong to the nuclear hormone receptor superfamily and act as ligand-inducible transcription factors. Therefore, most of the biological actions of vitamins A and D are now considered to be exerted through nuclear vitamin receptor-mediated gene expression. The vitamin A nuclear receptors compromise six members, three all-trans retinoic acid receptors (RARalpha, RARbeta, RARgamma) and three 9-cis retinoic acid receptors (RXRalpha, RXRbeta, RXRgamma) (Mangelsdorf et al. 1995). Unlike vitamin A receptors, only one member is identified for vitamin D. The present study investigating the vitamin D receptor function in gene expression in both cell culture and intact animals was undertaken to better understand the actions of the fat-soluble vitamin A and vitamin D at a molecular level.
The Institute of Molecular and Cellular Biosciences, The University of Tokyo, Japan. uskato@mail.ecc.u-tokyo.ac.jp.
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D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000235:genetics / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000235:genetics; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D020125:Mutation, Missense; D018167:Receptors, Calcitriol / Q000235:genetics* / Q000378:metabolism; D014158:Transcription, Genetic
D018167:Receptors, Calcitriol; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase; D002118:Calcium