Molecular targets of disulfiram action on song maturation in zebra finches.
Disulfiram, an aldehyde dehydrogenase inhibitor, interferes with normal song maturation when applied to brain nucleus HVC of male zebra finches. We present here evidence from Western blots and enzymatic assays showing that known disulfiram targets other than retinaldehyde-specific aldehyde dehydrogenase (zRalDH) are absent in HVC. These findings are consistent with the conclusion that disulfiram disrupts song maturation by interfering with retinoic acid production.
Denisenko-Nehrbass
N I
NI
College de France, U 536 INSERM, 11 Place Marcellin Berthelot, Paris 75005, France.
Mello
C V
CV
D000444:Aldehyde Dehydrogenase / Q000037:antagonists & inhibitors; D000818:Animals; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D003213:Conditioning, Psychological / Q000187:drug effects; D004221:Disulfiram / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D020308:Songbirds / Q000502:physiology*; D014212:Tretinoin / Q000378:metabolism; D014828:Vocalization, Animal / Q000187:drug effects* / Q000502:physiology
D004791:Enzyme Inhibitors; D014212:Tretinoin; D000444:Aldehyde Dehydrogenase; D004221:Disulfiram