Mouse models for sporadic cancer.
Much of the advancement in mouse models for cancer during the past 2 decades can be attributed to our increasing capacity to specifically modify the mouse germ line. The first generations of oncomice and tumor-suppressor gene knockouts are now being succeeded by regulatable or conditional mouse tumor models, which can be utilized more effectively to establish correlations between distinct genetic lesions and specific tumor characteristics and to design and improve therapeutic intervention strategies. In this review we try to give the reader a flavor of how the latest reagents can be utilized.
Division of Molecular Genetics and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, 1066 CX, The Netherlands.
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Meuwissen
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Jonkers
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Berns
D000818:Animals; D004195:Disease Models, Animal; D005544:Forecasting; D016147:Genes, Tumor Suppressor; D005816:Genetic Complementation Test; D051379:Mice; D018345:Mice, Knockout; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D015513:Oncogene Proteins / Q000235:genetics / Q000378:metabolism; D015533:Transcriptional Activation
D015513:Oncogene Proteins