[The in vitro metabolism of hainanensine derivative HH07A by rat liver microsomes].
The metabolism of hainanensine derivative HH07A has been studied in vitro with rat microsomes. A method of HPLC-DAD was developed for screening the metabolites from the microsomal incubation system. Two metabolites were found according to their UV spectra. One of them was extracted and purified with preparative HPLC and TLC, its chemical structure was identified by UV, IR, MS and NMR.
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
W J
WJ
Zhang
T H
TH
Zhou
Y Y
YY
Cui
D000818:Animals; D006248:Harringtonines / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D015394:Molecular Structure; D051381:Rats; D017208:Rats, Wistar
C095422:HH07A; D006248:Harringtonines; C030424:hainanensine