Protein translocation into mitochondria.
The biogenesis of mitochondria requires the translocation of most mitochondrial proteins across two biological membranes. Mitochondrial preproteins are synthesized in the cytosol carrying targeting information, that is recognized by specific receptor proteins. The precursor polypeptides are transported across both mitochondrial membranes via three large integral membrane protein complexes forming specialized preprotein translocases. A soluble protein complex in the matrix provides the ATP-dependent translocation force, responsible for the movement and unfolding of the bulk polypeptide chain. After the removal of the targeting sequence, imported proteins fold into their native conformation with the help of chaperone proteins in the mitochondrial matrix.
Schmidt
S
S
Institut für Biochemie und Molekularbiologie, Universität Freiburg, Germany.
Strub
A
A
Voos
W
W
D001693:Biological Transport, Active; D002352:Carrier Proteins / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D008928:Mitochondria / Q000502:physiology*; D021381:Protein Transport; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism
D002352:Carrier Proteins; D006360:Heat-Shock Proteins; D018160:Receptors, Cytoplasmic and Nuclear