Oxidative stress and vascular damage in hypertension.
Oxidative stress, a state of excessive reactive oxidative species activity, is associated with vascular disease states such as hypertension. In this review, we discuss the recent advances in the field of reactive oxidative species-mediated vascular damage in hypertension. These include the identification of redox-sensitive tyrosine kinases, the characterization of enzymatic sources of superoxide production in human blood vessels, and their relationship with vascular damage in atherosclerosis and hypertension. Finally, recent developments in the search for strategies to attenuate vascular oxidative stress are reviewed.
The British Heart Foundation Blood Pressure Group, Department of Medicine and Therapeutics, University of Glasgow, Glasgow, UK.
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C
Berry
M J
MJ
Brosnan
J
J
Fennell
C A
CA
Hamilton
A F
AF
Dominiczak
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology*; D002318:Cardiovascular Diseases / Q000209:etiology / Q000378:metabolism; D004195:Disease Models, Animal; D004967:Estrogens / Q000494:pharmacology; D018014:Gene Transfer Techniques; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology*; D008928:Mitochondria / Q000378:metabolism; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D019255:NADPH Oxidases; D009566:Nitrates / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000187:drug effects; D012307:Risk Factors; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000494:pharmacology; D014815:Vitamins / Q000494:pharmacology; D014969:Xanthine Oxidase / Q000378:metabolism
D000319:Adrenergic beta-Antagonists; D004967:Estrogens; D009566:Nitrates; D017382:Reactive Oxygen Species; D014815:Vitamins; D000804:Angiotensin II; C039642:peroxynitric acid; D006861:Hydrogen Peroxide; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases