Synthesis of 2-(allylthio)pyrazines as a novel cancer chemopreventive agent.
2-(Allylthio)pyrazine derivatives were designed as a novel cancer chemopreventive agent that functions through selective inhibtion of cytochrome P-450 and induction of phase II enzymes involved in the detoxification of carcinogens. A practical preparation method of 2-(allylthio) pyrazine derivatives was established by the reaction of 2-mercaptopyrazine and allylbromides in the presence of a catalytic antioxidant, DABCO (1,4-diazabicyclo[2,2,2] octane), in dimethylformamide at below 50 degrees C.
Lee
J W
JW
Yuan Research Center, Kyonggi-Do, Korea. leejw@yuhan.co.kr
Lee
B
B
Kim
N D
ND
D016588:Anticarcinogenic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy / Q000517:prevention & control; D011719:Pyrazines / Q000138:chemical synthesis* / Q000627:therapeutic use
C104935:2-(allylthio)pyrazine; D016588:Anticarcinogenic Agents; D004791:Enzyme Inhibitors; D011719:Pyrazines