An antimicrobial peptide gene found in the male reproductive system of rats.
Little is known about the innate defense mechanisms of the male reproductive tract. We cloned a 385-base pair complementary DNA and its genomic DNA named Bin1b that is exclusively expressed in the caput region of the rat epididymis and that is responsible for sperm maturation, storage, and protection. Bin1b exhibits structural characteristics and antimicrobial activity similar to that of cationic antimicrobial peptides, beta-defensins. Bin1b is maximally expressed when the rats are sexually mature and can be up-regulated by inflammation. Bin1b appears to be a natural epididymis-specific antimicrobial peptide that plays a role in reproductive tract host defense and male fertility.
State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, 320, Yue-Yang Road, Shanghai 200031, China.
P
P
Li
H C
HC
Chan
B
B
He
S C
SC
So
Y W
YW
Chung
Q
Q
Shang
Y D
YD
Zhang
Y L
YL
Zhang
D000818:Animals; D002478:Cells, Cultured; D003001:Cloning, Molecular; D018076:DNA, Complementary; D004822:Epididymis / Q000276:immunology* / Q000502:physiology; D004823:Epididymitis / Q000276:immunology; D004926:Escherichia coli / Q000254:growth & development; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D005796:Genes; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D016415:Sequence Alignment; D012741:Sexual Maturation; D013094:Spermatozoa / Q000502:physiology; D015854:Up-Regulation; D023083:beta-Defensins / Q000737:chemistry / Q000235:genetics* / Q000494:pharmacology / Q000502:physiology*
D018076:DNA, Complementary; D016376:Oligonucleotides, Antisense; D012333:RNA, Messenger; D023083:beta-Defensins