Frosted branch angiitis in a child with HIV infection.
OBJECTIVE
In adults with human immunodeficiency virus (HIV) infection, frosted branch angiitis is commonly associated with cytomegalovirus retinitis and responds to anti-cytomegalovirus therapy. We describe the first pediatric case of HIV-associated frosted branch angiitis.


METHODS
Case report.


RESULTS
A 7-year-old HIV-infected male with frosted branch angiitis was refractory to induction doses of intravenous ganciclovir and foscarnet over a 2-month period. Although cytomegalovirus antigenemia resolved, the angiitis only improved after subsequent treatment with systemic corticosteroids.


CONCLUSIONS
Frosted branch angiitis in this patient was not attributed to cytomegalovirus. The pathogenesis of HIV-associated frosted branch angiitis may differ between children and adults.
Clinical Research Training Program, National Eye Institute, National Institutes of Health, MSC 1863, 10 Center Drive, 10/10N112, Bethesda, MD 20892-1863, USA. hfine@alum.mit.edu
H F
HF
Fine
J A
JA
Smith
B L
BL
Murante
R B
RB
Nussenblatt
M R
MR
Robinson
D000998:Antiviral Agents / Q000627:therapeutic use; D002648:Child; D017726:Cytomegalovirus Retinitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D017245:Foscarnet / Q000627:therapeutic use; D015774:Ganciclovir / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D015658:HIV Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008297:Male; D012164:Retinal Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D012171:Retinal Vessels / Q000187:drug effects / Q000473:pathology*; D014657:Vasculitis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*
D000998:Antiviral Agents; D005938:Glucocorticoids; D017245:Foscarnet; D015774:Ganciclovir