Mix and match modules: structure and function of microneme proteins in apicomplexan parasites.
Microneme organelles are found in the apical complex of all apicomplexan parasites and play an important role in the invasion process. The recent identification of microneme proteins from different apicomplexan genera has revealed a striking conservation of structural domains, some of which show functional complementation across species. This supports the idea that the mechanism of host cell invasion across the phylum is conserved not only morphologically, but also functionally at the molecular level. Here, we review and summarize these recent findings.
Institute for Animal Health, Compton Laboratory, Compton, Newbury, Berkshire, UK RG16 0NN. fiona.tomley@bbsrc.ac.uk
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D000595:Amino Acid Sequence; D000818:Animals; D016782:Apicomplexa / Q000737:chemistry* / Q000469:parasitology / Q000472:pathogenicity*; D017124:Conserved Sequence; D015388:Organelles / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D021381:Protein Transport; D015800:Protozoan Proteins / Q000737:chemistry*
D015800:Protozoan Proteins