Mammalian MAP kinase signalling cascades.
Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many facets of cellular regulation. Initial research concentrated on defining the components and organization of MAPK signalling cascades, but recent studies have begun to shed light on the physiological functions of these cascades in the control of gene expression, cell proliferation and programmed cell death.
Chang
L
L
Department of Pharmacology, University of California San Diego, La Jolla 92093-0636, USA.
Karin
M
M
D000818:Animals; D004789:Enzyme Activation; D020935:MAP Kinase Signaling System; D008322:Mammals; D020929:Mitogen-Activated Protein Kinase Kinases / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D013379:Substrate Specificity
D020928:Mitogen-Activated Protein Kinases; D020929:Mitogen-Activated Protein Kinase Kinases