New products from alkali fusion of ginkgolides A and B.
Alkali fusion of ginkgolides A and B has afforded five unexpected products 3-7. Their structures were established from their spectral data and chemical reactions. They were evaluated for their in vitro activity to inhibit the platelet-activating factor-induced aggregation of rabbit platelets and show less potency than ginkgolides A and B.
Hu
L H
LH
Shanghai Institute of Materia Medica, Academia Sinica, China.
Chen
Z L
ZL
Xie
Y Y
YY
Jiang
Y Y
YY
Zhen
H W
HW
D000818:Animals; D004224:Diterpenes; D046934:Ginkgolides; D006863:Hydrogen-Ion Concentration; D007783:Lactones / Q000378:metabolism* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008968:Molecular Conformation; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; C045856:ginkgolide B