[Preparation and anti-HIV activity study of baicalien and its benzylated derivatives].
Baicalein (1) was prepared from baicalin by acid hydrolysis with yield of 24%. 5, 6-Dibenzyl-7-hydroxyl-flanone (4) and 6-benzyl-5, 7-dihydroxyl-flanone (5) were obtained by using different benzylating agents, and then hydrolyzing those benzylated compounds. The total yield of (4) and (5) were 5.9% and 5%, respectively. Both 4 and 5 were less effective than baicalien on inhibition of HIV-1 RT in vitro.
Zhao
J
J
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and the Peking Union Medical College, Beijing 100050.
Zhang
Z P
ZP
Chen
H S
HS
Chen
X H
XH
Zhang
X Q
XQ
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D044950:Flavanones; D005419:Flavonoids / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D054303:HIV Reverse Transcriptase / Q000187:drug effects; D006868:Hydrolysis; D018894:Reverse Transcriptase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology
D019380:Anti-HIV Agents; D044950:Flavanones; D005419:Flavonoids; D018894:Reverse Transcriptase Inhibitors; C038044:baicalin; C006680:baicalein; D054303:HIV Reverse Transcriptase