Cell-specific patterns of Cbfa1 mRNA and protein expression in postnatal murine dental tissues.
Cbfa1 (core binding factor alpha 1) is a transcription factor that is a key determinant of the osteoblastic lineage. Recent data showed that Cbfa1 is also highly expressed in early stages of tooth development and is involved in crown morphogenesis and cytodifferentiation of odontoblasts. Here we report the mRNA expression and protein localization of Cbfa1 in the mouse dentition in (later) stages of crown and root development. In addition to osteoblasts, osteocytes, chondrocytes, odontoblasts, dental follicle cells, cementoblasts and periodontal ligament cells, we report also Cbfa1 expression in dental epithelial cells (secretory and maturation ameloblasts) and several non-mineralizing cell types (hair follicles, ducts of salivary glands, and junctional epithelium of the gingiva).
Department of Oral Cell Biology, ACTA, Vrije Universiteit, van der Boechorststraat 7, 1081 BT, The, Amsterdam, Netherlands.
A L
AL
Bronckers
M A
MA
Engelse
A
A
Cavender
J
J
Gaikwad
R N
RN
D'Souza
D000367:Age Factors; D000565:Ameloblasts / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D050659:Core Binding Factor Alpha 1 Subunit; D050660:Core Binding Factors; D003739:Dental Cementum / Q000378:metabolism; D017403:In Situ Hybridization; D051379:Mice; D009363:Neoplasm Proteins; D009804:Odontoblasts / Q000378:metabolism; D010006:Osteoblasts / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D014018:Tissue Distribution; D014070:Tooth / Q000378:metabolism*; D014157:Transcription Factors / Q000096:biosynthesis*
D050659:Core Binding Factor Alpha 1 Subunit; D050660:Core Binding Factors; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D014157:Transcription Factors