Involvement of mitochondrial phospholipid hydroperoxide glutathione peroxidase as an antiapoptotic factor.
Although reactive oxygen species (ROS) such as superoxide and hydroperoxide are known to induce apoptotic cell death, little is known as to the apoptotic death signaling of mitochondrial ROS. Recent evidence has suggested that antioxidant enzymes in mitochondria may be responsible for the regulation of cytochrome c release and apoptotic cell death. This paper examines the current state of knowledge regarding the role of mitochondrial antioxidant enzymes, especially phospholipid hydroperoxide glutathione peroxidase. A model for the release of cytochrome c by lipid hydroperoxide has also been proposed.
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
K
K
Nomura
H
H
Imai
T
T
Koumura
Y
Y
Nakagawa
D000975:Antioxidants / Q000378:metabolism; D017209:Apoptosis / Q000502:physiology*; D002308:Cardiolipins / Q000378:metabolism; D003574:Cytochrome c Group / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008928:Mitochondria / Q000201:enzymology*; D008954:Models, Biological; D010713:Phosphatidylcholines / Q000378:metabolism; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D017382:Reactive Oxygen Species / Q000378:metabolism*
D000975:Antioxidants; D002308:Cardiolipins; D003574:Cytochrome c Group; D008054:Lipid Peroxides; D010713:Phosphatidylcholines; D017382:Reactive Oxygen Species; C057590:phosphatidylcholine hydroperoxide; D000080662:Phospholipid Hydroperoxide Glutathione Peroxidase; D005979:Glutathione Peroxidase