Raised interleukin-6 levels in obese patients.
OBJECTIVE
Obese patients demonstrate a variety of biochemical, metabolic, and pulmonary abnormalities. Inflammatory mediators such as tumor necrosis factor-alpha and interleukin-6 (IL-6) may have a direct effect on glucose and lipid metabolism. Hypoxemia in itself induces release of IL-6. The aim of this study was to examine the relationship between IL-6 levels in healthy volunteers (control group) and three different groups of obese patients: patients without obstructive sleep apnea syndrome (OSAS), patients with OSAS, and patients with obesity hypoventilation syndrome (OHS) (daytime baseline oxygen saturation of <93%).


METHODS
We measured serum IL-6 levels in 25 obese patients (body mass index of >35 kg/m2) and 12 healthy women.


RESULTS
The results demonstrate statistically significant differences in serum IL-6 levels between the control group (1.28 +/- 0.85 pg/mL) and obese patients without OSAS (7.69 +/- 5.06 pg/mL, p < 0.05) and with OSAS (5.58 +/- 0.37 pg/mL, p < 0.0005). In the patients with OHS, IL-6 concentrations were highest (43.13 +/- 24.27 pg/mL).


CONCLUSIONS
We conclude that serum IL-6 is increased in obese patients. The highest IL-6 levels were found in the patients with OHS.
Division of Anesthesiology, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel. l.roytblat@iname.com
L
L
Roytblat
M
M
Rachinsky
A
A
Fisher
L
L
Greemberg
Y
Y
Shapira
A
A
Douvdevani
S
S
Gelman
D000328:Adult; D005260:Female; D006801:Humans; D007040:Hypoventilation / Q000097:blood* / Q000150:complications; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D010101:Oxygen Consumption / Q000502:physiology; D020181:Sleep Apnea, Obstructive / Q000097:blood* / Q000150:complications; D013577:Syndrome
D015850:Interleukin-6