Cellular and molecular mechanisms of internalization of mycobacteria by host cells.
Mycobacteria are intracellular pathogens capable of invading mononuclear phagocytes, mucosal epithelial cells (including M cells) and Schwann cells. To enter cells, mycobacteria have been shown to interact with several molecules on macrophage and epithelial cell surfaces. This suggests adaptation to the host environment. In this review we address the strategies used by pathogenic mycobacteria to gain access to the intracellular environment.
Kuzell Institute for Arthritis & Infectious Diseases, California Pacific Medical Center Research Institute, San Francisco, USA. luizb@cooper.cpmc.org
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LE
Bermudez
F J
FJ
Sangari
D000818:Animals; D004847:Epithelial Cells / Q000382:microbiology; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology; D008264:Macrophages / Q000382:microbiology; D009092:Mucous Membrane / Q000166:cytology / Q000378:metabolism / Q000382:microbiology*; D009161:Mycobacterium / Q000378:metabolism / Q000502:physiology*; D010586:Phagocytes / Q000382:microbiology; D020545:Respiratory Mucosa / Q000382:microbiology; D012583:Schwann Cells / Q000382:microbiology