[Calorimetric evaluation of directly compressed tablets].
The paper studies the effect of the type of the disintegrating substance and the lubricant on the destruction heat of tablet materials and tablets. Destruction heat was determined by means of isoperibolic calorimetry. Tablet materials and tablets contained Avicel PH 101 as the dry binder, 10% of Primojel, Ac-Di-Sol, or Polyplasdone XL as disintegrating substances, and 5% of magnesium strearate or sodium laurylsulfate as the lubricants. The sum of destruction heats of the individual auxiliary substances equalled the found values in tablet materials and tablets. In tablets, in contrast to tablet materials, values of destruction heat higher by 57.9% were found. In the disintegrating substances and lubricants tested, the found values of destruction heats were dependent on the values of destruction heats of the individual auxiliary substances. In the disintegrating substances, a linear dependence of the total destruction heat (CDT) on the destruction heat of the disintegrating substances (DTR) was found, given by the relationship CDT = 0.797.DTR + 17.666 with the correlation coefficient r = 0.986.
Rehula
M
M
Katedra farmaceutické technologie Farmaceutické fakulty Univerzity Karlovy, Hradec Králové.
Lavická
J
J
Musilová
M
M
D000277:Adjuvants, Pharmaceutic; D002151:Calorimetry; D002482:Cellulose; D004355:Drug Stability; D006358:Hot Temperature; D013607:Tablets
D000277:Adjuvants, Pharmaceutic; D013607:Tablets; D002482:Cellulose