[Complex compound of heparin and glutamic acid: synthesis and effect on hemostasis parameters in vitro and in vivo].
A complex compound of high-molecular heparin and glutamic acid has been synthesized. This compound has anticoagulant, fibrinolytic, and antithrombotic properties in vitro. Single intravenous or chronic peroral introduction of the complex in normal animals imitates the activation of anticoagulation system. When the anticoagulation system in depressed, the complex restores or even activates the anticoagulant-fibrinolytic background of the serum it. The obtained data are discussed in physiological terms.
Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.
L A
LA
Liapina
G A
GA
Ziadetdinova
D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D002746:Chlorpromazine; D004586:Electrophoresis; D005176:Factor XIII / Q000032:analysis; D005337:Fibrin / Q000737:chemistry; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D018698:Glutamic Acid / Q000737:chemistry / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects*; D006493:Heparin / Q000737:chemistry / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats
D000925:Anticoagulants; D005343:Fibrinolytic Agents; D018698:Glutamic Acid; D005337:Fibrin; D006493:Heparin; D005176:Factor XIII; D002746:Chlorpromazine