The effect of high-fat diet on the development of obesity and serum leptin level in rats.
Ten male Wistar-albino rats were overfed with high-fat diet (margarine at the dose 40 g/kg body weight/day in addition to standard rat diet) during six months from the age of between 8-12 weeks. Ten male rats received a standard chow for the same period. The body weights of the overfed rats increased time dependently (basal 171.5 +/- 5, at sixth month 268 +/- 19 g), whereas those of the rats fed with standard chow did not increase significantly (basal 177 +/- 6.4, at sixth month 220 +/- 10 g). At the sixth month, mean body fat percentages were 36.3 +/- 6.7% and 24.2 +/- 5.4% respectively. Both total cholesterol-triglyceride levels and mean serum leptin levels were also higher than in the overfed rats (p < 0.01 and p < 0.05 respectively). The livers of all rats were histopathologically normal.


CONCLUSIONS
High-fat diet resulting in an increased body fat percentage in rats is associated with hyperleptinemia, hypercholesterolemia and hypertriglyceridemia.
Bahceci
M
M
University of Dicle, School of Medicine, Departments of Endocrinology and Metabolism, Diyarbakir, Turkey.
Tuzcu
A
A
Akkus
M
M
Yaldiz
M
M
Ozbay
A
A
D000818:Animals; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D002784:Cholesterol / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake / Q000502:physiology; D020738:Leptin / Q000097:blood*; D008297:Male; D009765:Obesity / Q000097:blood / Q000209:etiology*; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D020738:Leptin; D014280:Triglycerides; D002784:Cholesterol