Tibia metastasis without prostate specific antigen (PSA) increase following radical vesiculo-prostatectomy.
OBJECTIVE
PSA is regarded as the best method in the follow-up of prostate carcinoma. After radical vesiculo-prostatectomy the prostate carcinoma seldom recurs at zero or nearly zero PSA levels.


METHODS
The authors have used PSA since 1989 and they have found only one case where metastasis in the tibia came without an increase in PSA levels.


RESULTS
Tibia metastasis showed lower tissue activity of PSA than did the primary tumor in the prostate. The authors think this explains the zero PSA level when the metastasis developed.


CONCLUSIONS
The authors think based on their case that PSA free progression prostate cacncers may cases where the metastases do not produce PSA.
Hübler
J
J
Department of Urology, University Medical School, Pécs, Hungary.
Sükösd
F
F
Czipri
M
M
D000230:Adenocarcinoma / Q000097:blood / Q000556:secondary* / Q000601:surgery*; D000368:Aged; D001859:Bone Neoplasms / Q000097:blood / Q000556:secondary*; D006801:Humans; D008297:Male; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery*; D013977:Tibia
D017430:Prostate-Specific Antigen