Pathophysiological relevance of mitochondria in NAD(+) metabolism.
Pyridine nucleotides are mostly stored within mitochondria where they are involved in different functions ranging from energy metabolism to cellular signaling. Here we discuss the mechanisms of mitochondrial NAD(+) metabolism and release that may contribute to the crucial roles played by these organelles as triggers or amplifiers of physiological and pathological events.
Di Lisa
F
F
Dipartment de Chimica Biologica, Università di Padova, Italy. dilisa@civ.bio.unipd.it
Ziegler
M
M
D017209:Apoptosis; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D015398:Signal Transduction
D009243:NAD; D009249:NADP