[Analysis of the striato-pallidal interactions in regulation of avoidance behavior].
Impairment of avoidance conditioning in the shuttle box was found in rats with bicuculline intrapallidal administration, as well as activation of the conditioning and stereotyped movements during amphetamine intrastriatal administration. These neuropharmacological effects upon both ganglia areas induced dynamic behavioural changes in the avoidance conditioning and open-field locomotor activity. The findings suggest involvement of neostriatalpallidal relationship in control of avoidance conditioning and complex behavioural acts.
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I. P. Pavlov Institute of Physiology, Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia, and St. Petersburg I. P. Pavlov State Medical University, 197022, St. Petersburg, Leo Tolstoy St., 6/8, Russia.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D001640:Bicuculline / Q000494:pharmacology; D003214:Conditioning, Classical / Q000502:physiology; D015259:Dopamine Agents / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D005917:Globus Pallidus / Q000502:physiology*; D008297:Male; D008845:Microinjections; D017072:Neostriatum / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time
D015259:Dopamine Agents; D018756:GABA Antagonists; D000661:Amphetamine; D001640:Bicuculline