Antiviral activity of the products of cyclization of dimethyl 2-[(1-arylamino-1-arylmethylidene)hydrazono]succinate.
In this research, conditions of cyclization of dimethyl 2-[(1-arylamino-1-arylmethylidene)hydrazono]succinate 1-5 leading to the formation of 3,4-diaryl-5-carboxymethyl-1,2,4-triazole 6-10 and methyl 2-(5-oxo-3,4-diaryl-1,4,5,6-tetrahydro-1,2,4-triazine-6-ylidene)acetates 11-15 and the biological activity of some of them have been examined. Their chemical structures were confirmed by IR, 1H-NMR, EI-MS and elemental analysis. Substances 8 and 13 exhibited moderate virucidal activity and partially inhibited absorption of the viruses to the susceptible cells. The acute toxicity of compounds 6-10 was established. For compounds 8 and 13, the influence on the central nervous system of mice and rats in behavioral tests was examined.
Department of Organic Chemistry, Medical University, Staszica 6, 20-081, Lublin, Poland. pitucha@panaceum.am.lublin.pl
B
B
Modzelewska-Banachiewicz
T
T
Kamińska
D000260:Adenoviruses, Human / Q000187:drug effects; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001393:Azoles / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D004686:Encephalomyocarditis virus / Q000187:drug effects; D005260:Female; D006367:HeLa Cells / Q000187:drug effects / Q000821:virology; D006801:Humans; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D014227:Triazines / Q000737:chemistry / Q000494:pharmacology*; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D001393:Azoles; D014227:Triazines; D014230:Triazoles