Structural implications for the design of molecular vaccines.
The major histocompatibility complex molecules bind and present short antigenic peptide fragments on the surface of antigen presenting cells to T-cell receptors. Recognition of peptide-MHC by cytotoxic T-cells initiates a cascade of signals to T-cells, which in turn destroy the antigen presenting cell. In the design of molecular vaccines for the treatment of diseases, an understanding of the 3-dimensional structure of MHC class I and is interaction with both peptide and T-cell receptor is an important prerequisite. In this review, we will discuss such crystal structures, as well as structures of glycopeptides and alternative T-cell antigens presented by MHC molecules.
Department of Molecular Biology and Skaggs Institute for Chemical Biology (BCC-206), Scripps Research Institute, 10550 N Torrey Pines Road, La Jolla, CA 92037, USA. vapos@scripps.edu
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Apostolopoulos
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Yu
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McKenzie
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Wilson
D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D019496:Cancer Vaccines / Q000302:isolation & purification*; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008024:Ligands; D008958:Models, Molecular; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D010455:Peptides / Q000737:chemistry / Q000276:immunology; D011485:Protein Binding; D011948:Receptors, Antigen, T-Cell / Q000737:chemistry / Q000378:metabolism
D019496:Cancer Vaccines; D015395:Histocompatibility Antigens Class I; D008024:Ligands; D010455:Peptides; D011948:Receptors, Antigen, T-Cell