[Capozide-50 alone and in combination with melatonin in therapy of hypertension].
Monotherapy with caposide-50 (C-50) was compared to combined therapy C-50 + melatonin in 22 patients with essential hypertension stage II (mean age 60 years). The patients were divided into two groups. Group 1 received C-50 at 8.00 a.m., group 2 received C-50 at 8.00 a.m. and melatonin at 10.00 p.m. in a dose 3 mg. Before the treatment and 14 days after it echo-CG was made to assess hemodynamics. Also, 24-h monitoring of arterial pressure was performed. The findings were analysed with variance statistics and cosinor-analysis. Group 1 achieved a moderate hypotensive effect. Circadian rhythm of systolic blood pressure was abnormal. Group 2 patients achieved more pronounced decline of systolic, diastolic and mean arterial pressures. Circadian rhythm of these pressure did not return to normal.
Zaslavskaia
R M
RM
Biiasilov
N S
NS
Akhmetov
K Zh
KZh
Teĭblium
M M
MM
D000975:Antioxidants / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage*; D002940:Circadian Rhythm; D004334:Drug Administration Schedule; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008550:Melatonin / Q000008:administration & dosage*; D008875:Middle Aged; D011379:Prognosis
D000975:Antioxidants; D004338:Drug Combinations; C044959:captopril, hydrochlorothiazide drug combination; D006852:Hydrochlorothiazide; D002216:Captopril; D008550:Melatonin