[Independence of DNA repair after gamma irradiation and radioadaptive response in lymphocytes of patients with Bloom syndrome].
The evidence for independency of DNA repair and radioadaptive response (RAR) was obtained in cells of patients with Bloom syndrome. The cells of patients with Bloom syndrome (human autosomal recessive disorder) are characterized by chromosomal instability and increased risk of malignancy at an early age. Resynthesis of gamma-induced DNA breaks wasn't find in lymphocytes of 3 patients with Bloom syndrome while the level of RAR was the same as in the cells of healthy donors.
Vavilov Institute of General Genetic, Russian Academy of Science, Moscow, 117809 Russia.
G D
GD
Zasukhina
I M
IM
Vasil'eva
A N
AN
Semiachkina
D001816:Bloom Syndrome / Q000235:genetics*; D002478:Cells, Cultured; D002648:Child; D004249:DNA Damage; D004260:DNA Repair; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects*; D011836:Radiation Tolerance