[Antibacterial activity of urine after administration of ofloxacin for 5 days].
The antibacterial activity of ofloxacin was evaluated in urine over a period of 96 h after oral administration for 5 days of 200 mg twice a day in 12 healthy female volunteers. Bacteriostatic and bactericidal activity of urines were studied for five strains of enterobacterias recovered from urinary infections: two strains of Escherichia Coli Nal-S and Nal-R, two strains of Proteus mirabilis Nal-S and Nal-R, and one strain of Klebsiella pneumoniae Nal-S. Mean urinary concentrations of ofloxacin were very high during the first 12 h following last intake. They were still above 7 mg/l till the 48th hour and above 1.6 mg/l till the 72nd hour. Bactericidal activity of urine was present for 72 h in respect of four strains studied at that time; urine was not bactericidal as regards E. coli Nal-R. After 5 days of oral treatment with ofloxacin (200 mg b.i.d.), urine retains a bactericidal activity for at least 72 h against bacterial strains of urinary tract infections.
Drugeon
H
H
Laboratoire de Microbiologie, Faculté de Médecine, Nantes, France.
Veyries
M L
ML
Levacher
M
M
Garnier
M
M
Aymard
G
G
Giroud
J P
JP
Rouveix
B
B
D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage / Q000652:urine*; D004926:Escherichia coli / Q000254:growth & development / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007711:Klebsiella pneumoniae / Q000254:growth & development / Q000302:isolation & purification; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000008:administration & dosage / Q000097:blood / Q000652:urine*; D011513:Proteus mirabilis / Q000254:growth & development / Q000302:isolation & purification; D013997:Time Factors; D014552:Urinary Tract Infections / Q000382:microbiology* / Q000652:urine
D000892:Anti-Infective Agents, Urinary; D015242:Ofloxacin