[Acute kidney failure and losartan: a recently observed event of antagonists of angiotensin II AT1 receptors].
Losartan is the first of a new category of drug that inhibits angiotensin II (ANG II) AT1 receptors antagonists. This drug lowers blood pressure by inhibiting the activity of ANG II and reduces proteinuria and progression of chronic renal failure (CRF). It seems therefore an extremely interesting drug. Aim of this study is to describe 3 cases of acute renal failure (ARF), occurred during therapy with losartan. None of the patients showed renal arteries stenosis or other predisposing factors for the development of ARF. In conclusion, we want pointed out that losartan could affect renal function in a similar way as angiotensin converting enzyme inhibitors (ACEI). We suggested that use of losartan in risk situations, like old age, preexiting CRF, stenosis of renal arteries, solitary kidney and diuretic therapy, should be carefully monitored as well as that of ACE I.
Servizio di Nefrologia e Dialisi, Ospedale degli Infermi, 13900 Biella.
P
P
Dionisio
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M
Valenti
E
E
Caramello
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R
Bergia
R
R
Cravero
I M
IM
Berto
B
B
Agostini
G
G
Monaci
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P
Bajardi
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D000369:Aged, 80 and over; D057911:Angiotensin Receptor Antagonists; D005260:Female; D006801:Humans; D019808:Losartan / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D057911:Angiotensin Receptor Antagonists; D019808:Losartan