Effect of oral contraceptive steroid hormones on metabolic parameters of streptozotocin-induced diabetic rat.
This study examined the effect of 0.05 mg norgestrel + 0.01 ethinyl estradiol (NEE) Kg x body wt(-1) on body weight, random blood glucose, glycosylated hemoglobin, and plasma insulin levels in streptozotocin-induced diabetic rats. Weight loss, blood glucose, glycosylated hemoglobin, and plasma insulin values of rats treated with NEE before and after the onset of diabetes were not significantly different from that of untreated diabetic rats. In conclusion, oral administration of these contraceptive steroid hormones does not significantly alter the metabolic parameters of diabetic rats.
Adeghate
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Department of Human Anatomy, United Arab Emirates University, Al Ain, United Arab Emirates. eadeghate@uaeu.ac.ae
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D003278:Contraceptives, Oral, Hormonal / Q000633:toxicity*; D003280:Contraceptives, Oral, Synthetic / Q000633:toxicity*; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D004997:Ethinyl Estradiol / Q000633:toxicity*; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism; D007328:Insulin / Q000097:blood; D009644:Norgestrel / Q000633:toxicity*; D045167:Progesterone Congeners / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D003278:Contraceptives, Oral, Hormonal; D003280:Contraceptives, Oral, Synthetic; D004997:Ethinyl Estradiol; D006442:Glycated Hemoglobin; D007328:Insulin; D009644:Norgestrel; D045167:Progesterone Congeners