[Antimicrobial activity of hyaluronic acid].
In this work the biological activity of hyaluronic acid (HA), isolated from fowl crests, is evaluated. The data on the physico-chemical analysis of HA are presented. The preparation obtained is characterized by a high content of the main substance and high relative viscosity. Sterilization conditions for HA, depending on the degree of microbial contamination of the preparation, were carried out. As revealed in this study, irradiation with a dose of 1.0 Mrad is sufficient for obtaining a sterile preparation. HA has been found to possess inhibiting activity with respect to Pseudomonas.
State Research Center of Virology and Biotechnology Vector, Koltsovo, Novosibirsk Region, Russia.
I F
IF
Radaeva
G A
GA
Kostina
S G
SG
Il'ina
R N
RN
Kostyleva
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D006820:Hyaluronic Acid / Q000494:pharmacology*; D011549:Pseudomonas / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D006820:Hyaluronic Acid