Low frequency of microsatellite instability in hereditary prostate cancer.
OBJECTIVE
To investigate whether there is widespread microsatellite instability (MSI) in families with hereditary prostate cancer (HPC).


METHODS
Eighty-four prostate tumours from 80 Swedish men in 35 families with HPC were screened for genetic instability at microsatellite marker loci BAT-25, BAT-26, BAT-34C4, D2S123 and D17S250.


RESULTS
MSI was detected in only five individuals from different families. Three tumours (4%) were unstable at more than two MSI loci and hence classified as high-frequency MSI (MSI-H) according to a previous definition. Interestingly, two of the MSI-H tumours were from patients in families with both HPC and familial colon cancer.


CONCLUSIONS
Widespread MSI is a rare event in hereditary prostate cancer, indicating that defective DNA mismatch repair is not an important element in the genesis of HPC.
Department of Radiation Sciences, Oncology, Umeå University, Sweden.
A K
AK
Ahman
B A
BA
Jonsson
J E
JE
Damber
A
A
Bergh
H
H
Grönberg
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000032:analysis; D020022:Genetic Predisposition to Disease / Q000235:genetics; D005820:Genetic Testing; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D010375:Pedigree; D011471:Prostatic Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm