Insulin secretion in glucose-tolerant offspring of type 2 diabetes patients in Trinidad, West Indies.
BACKGROUND
Genetics and environmental factors play vital roles in type 2 diabetes. To gain insight into its pathogenesis, early study of offspring of affected patients is needed.


METHODS
Thirty-four offspring of patients with type 2 diabetes and 27 nondiabetic control subjects matched for sex, height, weight, and waist-to-hip ratio had standard oral glucose tolerance tests (75 g glucose in 300 mL water). Homeostasis model assessment was used in measuring insulin resistance and sensitivity.


RESULTS
Offspring had significantly higher mean fasting serum insulin (126.6 +/- 10.3 vs 87.5 +/- 6.9 pmol/L), incremental insulin at 30 to 150 minutes, and body mass index and lower insulin sensitivity than control subjects (49.9% +/- 3.1% vs. 71.9% +/- 5.6%), despite similar fasting plasma glucose concentrations.


CONCLUSIONS
As in other populations, the offspring of Caribbean patients with type 2 diabetes are at greater risk for development of diabetes independent of obesity.
Department of Paraclinical Sciences, Faculty of Medical Sciences, University of the West Indies, Saint Augustine, Trinidad.
C E
CE
Ezenwaka
G
G
Davis
N V
NV
Offiah
D000328:Adult; D000886:Anthropometry; D044383:Black People / Q000235:genetics; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000235:genetics* / Q000378:metabolism; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007333:Insulin Resistance; D000078790:Insulin Secretion; D016014:Linear Models; D008297:Male; D009765:Obesity; D012307:Risk Factors; D014300:Trinidad and Tobago / Q000453:epidemiology
D001786:Blood Glucose; D007328:Insulin