Pathologic markers of allograft arteriopathy: insight into the pathophysiology of cardiac allograft chronic rejection.
Transplant-associated coronary artery disease (CAD) is the principal limiting factor for the long-term survival of heart transplant patients. This review discusses early risk factors for the subsequent development of transplant-associated CAD. Early risk factors associated with a prothrombogenic microvasculature, such as deposition of microvascular fibrin, depletion of vascular tissue plasminogen activator, presence of endothelial activation of the allograft arterial tree, and loss of vascular antithrombin, as well as changes in circulation (ie, detectable serum cardiac troponin I and elevated serum soluble intercellular adhesion molecule-1 levels) are presented and discussed. New therapies that could improve the status of the allograft microvasculature and may prevent or mitigate the development of transplant-associated CAD are considered.
Labarrere
C A
CA
Methodist Research Institute, Clarian Health Partners, (Methodist, Indiana University, Riley Hospitals), 1701 N. Senate Blvd., Indianapolis, IN 46202, USA. clabarriere@clarian.com
Nelson
D R
DR
Park
J W
JW
D000991:Antithrombins / Q000378:metabolism; D015415:Biomarkers / Q000097:blood; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000503:physiopathology*; D004730:Endothelium, Vascular / Q000502:physiology; D005337:Fibrin / Q000378:metabolism; D006084:Graft Rejection / Q000473:pathology / Q000503:physiopathology*; D006085:Graft Survival; D016027:Heart Transplantation / Q000276:immunology* / Q000379:methods; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D012307:Risk Factors; D010959:Tissue Plasminogen Activator / Q000097:blood; D023001:Transplantation Tolerance / Q000502:physiology; D019210:Troponin I / Q000378:metabolism
D000991:Antithrombins; D015415:Biomarkers; D019210:Troponin I; D018799:Intercellular Adhesion Molecule-1; D005337:Fibrin; D010959:Tissue Plasminogen Activator