Pressure lavage under ultrasound guidance: a new approach for outpatient treatment of intrauterine adhesions.
OBJECTIVE
To present pressure lavage under ultrasound guidance (PLUG) as a new therapeutic procedure for selected cases of intrauterine adhesions (IUA).


METHODS
An open clinical investigation with no control group.


METHODS
Teaching hospital.


METHODS
Seven consecutive patients referred to our department for secondary amenorrhea due to IUA.


METHODS
A newly developed technique based on sonohysterography was used to monitor the effects of intrauterine injections of saline solution on the continuous accumulation of saline in the uterine cavity for the mechanical disruption of IUA.


METHODS
Lysis of intrauterine adhesions, restoration of menses, and increased pregnancy rate in infertile patients.


RESULTS
Five patients with mild IUA obtained satisfactory lysis of adhesions by the use of the PLUG technique. A second-look hysteroscopy after 1 month showed that filmy adhesions persisted in two patients with moderate IUA. These adhesions were removed successfully during hysteroscopy. Restoration of menses was obtained and has continued in all patients. Two of the three infertile patients became pregnant.


CONCLUSIONS
This technique is safe and ideal as an in-office procedure. PLUG allows complete lysis in mild IUA cases, and the need for therapeutic, and possibly follow-up hysteroscopy, can be avoided. In moderate IUA cases, the procedure may represent a useful initial step in reducing the need for operative hysteroscopy.
Coccia
M E
ME
Department of Obstetrics and Gynecology, Perinatology, and Human Reproduction, University of Florence Medical School, Italy. mecoccia@tin.it
Becattini
C
C
Bracco
G L
GL
Pampaloni
F
F
Bargelli
G
G
Scarselli
G
G
D000328:Adult; D000553:Ambulatory Care; D005260:Female; D006801:Humans; D011312:Pressure; D012965:Sodium Chloride / Q000008:administration & dosage*; D012996:Solutions; D007507:Therapeutic Irrigation / Q000009:adverse effects; D000267:Tissue Adhesions / Q000000981:diagnostic imaging / Q000628:therapy*; D014463:Ultrasonography; D014591:Uterine Diseases / Q000000981:diagnostic imaging / Q000628:therapy*
D012996:Solutions; D012965:Sodium Chloride