CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I.
The development of cellular immune responses in primary human immunodeficiency virus type-1 (HIV-1) infection is accompanied by a dramatic decrease in plasma viremia and resolution of the acute clinical syndrome. The full nature of the immunological response and its consequences on HIV pathogenesis is still largely a mystery, but significant progress has been achieved in the characterization of some of the players involved. Several studies indicate that noncytolytic HIV suppression by CD8+ T lymphocytes may be inversely associated with viral load suggesting that this antiviral activity is important in host control of HIV replication. This review focuses on this antiviral activity by CD8+ T lymphocytes, which is distinct from that activity elicited by some cytolytic CD8+ T lymphocytes (CTLs).
Tomaras
G D
GD
Department of Surgery, Center for AIDS Research, Duke University Medical Center, Durham, NC 27710, USA. gdt@duke.edu
Greenberg
M L
ML
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D004195:Disease Models, Animal; D015658:HIV Infections / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology; D015302:Simian Immunodeficiency Virus / Q000276:immunology