Cytochrome P450 2C is an EDHF synthase in coronary arteries.
Studies designed to elucidate the identity of the potent vasodilator autacoid endothelium-derived hyperpolarizing factor (EDHF) in the coronary vascular bed have highlighted a role for vascular cytochrome P450 (CYP) enzymes in cardiovascular homeostasis. Not only is there strong evidence suggesting that the putative coronary EDHF synthase is an endothelially expressed CYP epoxygenase, but CYP products such as epoxyeicosatrienoic acids and reactive oxygen species have been implicated in the regulation of intracellular signalling cascades and vascular cell proliferation.
Fleming
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Institut für Kardiovaskuläre Physiologie, Klinikum der J.W.G.-Universität, Theodor-Stern-Kai 7, D-60590, Frankfurt am Main, Germany. Fleming@em.uni-frankfurt.de
D000818:Animals; D001685:Biological Factors / Q000378:metabolism*; D003331:Coronary Vessels / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D015398:Signal Transduction
D001685:Biological Factors; C067410:endothelium-dependent hyperpolarization factor; D003577:Cytochrome P-450 Enzyme System