Determination of nicotinamide (NA) using its polarographic catalytic wave in the presence of KIO3.
Nicotinamide (NA) yields a polarographic catalytic wave with a peak potential -1.38 V (vs. SCE) in 0.1 mol/L HAc-NaAc (pH 4.7)/4 x 10(-3) mol/L KIO3 buffer solution. The sensitivity of the catalytic wave increased in one order of magnitude as compared to that of the responding reduction wave without KIO3. Based on this observation, a new method for the determination of NA was recommended. The second order derivative peak current was proportional to the NA concentration in the range of 5 x 10(-8)- 6 x 10(-7) mol/L. 0.11-fold vitamin B1, 0.13-fold B2, 0.14-fold B6 and 8-fold nicotinic acid amounts do not interfere the determination of 1 x 10(-6) mol/L NA. The proposed method was used to determine the NA content in multivitamin tablets, with good agreement to the declared amount.
Song
J
J
Institute of Electroanalytical Chemistry, Northwest University, Xi'an, People's Republic of China. eact@nwu.ed.cn
Su
Y
Y
Guo
W
W
D006863:Hydrogen-Ion Concentration; D007452:Iodates / Q000737:chemistry / Q000494:pharmacology*; D009536:Niacinamide / Q000032:analysis* / Q000592:standards; D011048:Polarography / Q000592:standards; D017680:Potassium Compounds / Q000737:chemistry / Q000494:pharmacology*; D011736:Pyridoxine / Q000494:pharmacology; D013831:Thiamine / Q000494:pharmacology
D007452:Iodates; D017680:Potassium Compounds; D009536:Niacinamide; C039693:potassium iodate; D011736:Pyridoxine; D013831:Thiamine