Evidence for gliotoxin-glutathione conjugate adducts.
The equilibrium constant for the gliotoxin/glutathione pair was found to be 1200+/-100 M(-1) at pH 7.0 at 25 degrees C. Under conditions where the reaction was quenched rapidly with the addition of acid, gliotoxin-glutathione conjugate adducts were detected.
Bernardo
P H
PH
Department of Chemistry, The Faculties, Australian National University, ACT.
Chai
C L
CL
Deeble
G J
GJ
Liu
X M
XM
Waring
P
P
D002851:Chromatography, High Pressure Liquid; D005912:Gliotoxin / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D019803:Glutathione Disulfide / Q000378:metabolism
D005912:Gliotoxin; D005978:Glutathione; D019803:Glutathione Disulfide