Registered (1)H and (3)He magnetic resonance microscopy of the lung.
Using in vivo magnetic resonance microscopy, registered (1)H and hyperpolarized (3)He images of the rat lung were obtained with a resolution of 0.098 x 0.098 x 0.469 mm (4.5 x 10(-3) mm(3)). The requisite stability and SNR was achieved through an integration of scan-synchronous ventilation, dual-frequency RF coils, anisotropic projection encoding, and variable RF excitation. The total acquisition time was 21 min for the (3)He images and 64 min for the (1)H image. Airways down to the 6th and 7th orders are clearly visible. Magn Reson Med 45:365-370, 2001.
Johnson
G A
GA
Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina 27710, USA.
Cofer
G P
GP
Hedlund
L W
LW
Maronpot
R R
RR
Suddarth
S A
SA
D000818:Animals; D016880:Anisotropy; D006371:Helium; D006859:Hydrogen; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D007554:Isotopes; D008168:Lung / Q000473:pathology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008853:Microscopy / Q000379:methods*; D051381:Rats; D011916:Rats, Inbred F344; D012680:Sensitivity and Specificity
D007554:Isotopes; D006371:Helium; D006859:Hydrogen