[Anoxic encephalopathy of the term neonate and brain hypothermia].
The outcome of term newborns with birth asphyxia and moderate to severe hypoxic ischemic encephalopathy remains very poor. After the primary phase of energy failure during asphyxia, neuronal cell metabolism may deteriorate in a secondary phase of brain injury. The window between these two phases opens the way to potential neuroprotective treatments such as brain cooling. Promising experimental data on controlled hypothermia need to be examined with clinical trials.
Service de Réanimation Néonatale, Hôpital Antoine-Béclère, 92141 Clamart Cedex.
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Zupan
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Boithias
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Razafimahefa
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Lamboley
D001238:Asphyxia Neonatorum / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007036:Hypothermia, Induced / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods*; D002534:Hypoxia, Brain / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D007231:Infant, Newborn; D011379:Prognosis; D016896:Treatment Outcome