Association between Novelty Seeking and the -521 C/T polymorphism in the promoter region of the DRD4 gene.
Association between the human personality trait 'Novelty Seeking' and the polymorphism of the DRD4 gene was first reported by Ebstein and Benjamin in 1996. This was soon followed by replication studies in various ethnic groups and by studying the role of other neurotransmitter receptor and transporter genes in the genetic determination of human temperament. More recently, several polymorphic sites of the upstream regulatory region of the DRD4 gene have been described. Among these the -521 C/T single nucleotide polymorphism (SNP) was shown to be associated with the Novelty Seeking (NS) scores of the Temperament and Character Inventory (TCI) in a Japanese male population. We have investigated the -521 C/T SNP polymorphism in a Caucasian (Hungarian) population, and here we report a replication of the Japanese findings, in an association study involving 109 healthy Hungarian volunteers. We found a weak association between NS and CC vs CT or TT genotypes (P < 0.06). Examination of this relation in male and female sex groups, however, strengthened the association for females (P < 0.01), but showed no genotypic effect for males.
Institute of Medical Chemistry, Molecular Biology and Pathobiochemistry, Semmelweis University, Budapest POB 260, 1444, Hungary.
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Ronai
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Szekely
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Nemoda
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Lakatos
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Gervai
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Staub
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Sasvari-Szekely
D000293:Adolescent; D000328:Adult; D001923:Brain Chemistry / Q000235:genetics*; D005106:Exploratory Behavior; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D010551:Personality / Q000235:genetics; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4; D012737:Sex Factors
C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4