Visceral pain in humans: lessons from animals.
Acute and persistent neuropathic and inflammatory injuries of healthy animals have contributed importantly to our current understanding of nociception and pain. Studies have differentiated somatic from visceral nociceptive input, and elucidated the pathways of transduction, transmission, perception, and modulation of the input. Other animal studies have identified important genetic and environmental influences on responses to nociception. Studies of naturally occurring visceral pain syndromes in animals also have added to our understanding of comparable syndromes in humans. Because of the aversive nature of pain, use of healthy animals to study pain in the service of other animals and humans is a decision to be taken carefully, and carries with it the responsibility of treating the animals as humanely as possible.
Buffington
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Department of Veterinary Clinical Sciences, Ohio State University Veterinary Hospital, 601 Vernon L. Tharp Street, Columbus, OH 43210, USA. buffington.1@osu.edu
D000827:Animal Welfare; D000818:Animals; D002415:Cats; D002908:Chronic Disease; D018856:Cystitis, Interstitial / Q000209:etiology / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D008297:Male; D051379:Mice; D009434:Neural Pathways / Q000503:physiopathology; D010146:Pain / Q000209:etiology / Q000503:physiopathology*; D059408:Pain Management; D010147:Pain Measurement; D051381:Rats; D012107:Research Design; D013001:Somatoform Disorders / Q000209:etiology / Q000503:physiopathology* / Q000628:therapy; D014781:Viscera / Q000294:innervation / Q000503:physiopathology*