The study of organic nitrates, part IV. Chemical and pharmacological study of N-(1-methylethyl)-3-(1-naphthalenyloxy)-2-nitroxypropylamine--potential NO donor.
The reaction of N-(1-methylethyl)-3-(1-naphthalenyloxy)-2-nitroxypropylamine (nitrate analogue of propranolol) with hydrochloride of ethyl ester of L-cysteine at pH 7.7, temp. 37 degrees C was studied. The course of the reaction was monitored by HPLC method. It was found that at these conditions the substrates react and the main product of the decomposition of the nitrate of propranolol analogue is propranolol, nitrate and nitrite ions. The reaction has been described qualitatively and quantitatively. The influence of nitrate analogue of propranolol and propranolol alone on arterial blood pressure and heart rate in normotensive and hypertensive rats (SHR) was also studied. It has been found that both compounds exert a similar effect.
Korzycka
L
L
Department of Pharmaceutical Chemistry and Drug Analysis, Medical University of Lódź, Poland.
Szmigielska
H
H
Czarnecka
E
E
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D020030:Nitric Oxide Donors / Q000138:chemical synthesis* / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011437:Propylamines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
C424102:N-(1-methylethyl)-3-(1-naphthalenyloxy)-2-nitroxypropylamine; D020030:Nitric Oxide Donors; D011437:Propylamines; D011433:Propranolol