Prevention of secondary osteoporosis postmenopause in hemiplegia.
OBJECTIVE
To study secondary osteoporosis postmenopause in women with hemiplegia and to show the therapeutic effects of etidronate and how osteoporotic conditions relate to the activities of daily living (ADL).


METHODS
Eighty-one postmenopausal women with hemiplegia were admitted within 6 mo of their first cerebrovascular accident. The bone mineral density (BMD) and biochemical markers of bone turnover were measured at the time of admission. Forty women (treatment group) received a 2-wk administration of etidronate. Forty-one women (control group) were not administered etidronate.


RESULTS
After completing a 3-mo rehabilitation program, BMD levels were remeasured. ADL was evaluated by FIM. The low ADL group had a larger decrease in BMD than the high ADL group. For the control group, the BMD rate of change on the paretic side of the femoral neck was -9.6%/3 mo for the low ADL group. BMD loss was reduced significantly by the administration of etidronate for the low ADL group.


CONCLUSIONS
Results indicate that ADL corresponds to the progression of osteoporosis in postmenopausal women with hemiplegia and that increasing the level of ADL will reduce the progression of osteoporosis. Use of etidronate has also been proven to have a suppressive effect on the BMD decrease in women.
Ikai
T
T
Tokyo Metropolitan Rehabilitation Hospital, Japan.
Uematsu
M
M
Eun
S S
SS
Kimura
C
C
Hasegawa
C
C
Miyano
S
S
D015502:Absorptiometry, Photon; D000203:Activities of Daily Living; D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D015519:Bone Density; D018450:Disease Progression; D012968:Etidronic Acid / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D015577:Geriatric Assessment; D006429:Hemiplegia / Q000150:complications* / Q000503:physiopathology / Q000534:rehabilitation; D006801:Humans; D015675:Osteocalcin / Q000097:blood; D015663:Osteoporosis, Postmenopausal / Q000000981:diagnostic imaging / Q000209:etiology* / Q000378:metabolism / Q000517:prevention & control*; D011877:Radionuclide Imaging
D000596:Amino Acids; D015675:Osteocalcin; C015484:pyridinoline; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase; D012968:Etidronic Acid