Abnormal liver function tests in a patient fed with total parenteral nutrition and treated with octreotide.
Octreotide is a long-acting analog of somatostatin, a hypothalamic release-inhibiting hormone. It is sometimes used therapeutically to relieve symptoms associated with acromegaly and gastroenteropancreatic endocrine tumors. It has also been used in the treatment of short-bowel syndrome and gastrointestinal and biliary fistulae. We report a patient with biliary leakage due to Marizzi's syndrome treated with total parenteral nutrition and octreotide who developed abnormal liver function tests that improved when the two treatments were stopped. We also review the literature regarding abnormal liver function tests in patients on total parenteral nutrition.
Department of Chemical Pathology, Guy's and St Thomas' and University Hospital Lewisham, London, UK. martin.crook@gstt.sthames.nhs.uk
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D005260:Female; D005765:Gastrointestinal Agents / Q000009:adverse effects*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000503:physiopathology*; D008111:Liver Function Tests; D008875:Middle Aged; D015282:Octreotide / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*
D005765:Gastrointestinal Agents; D015282:Octreotide