[Experimental study of anti-tumor immunity induced by B7 vaccine of a highly malignant murine leukemic T cell line (L615)].
OBJECTIVE
To assess the potential of B7-1 vaccine in inducing immunity to leukemic cells.


METHODS
B7-1 gene was introduced into L615 cells and then the positive clone (L615-B7) highly expressing B7-1 was selected. Tumorigenic and immunoprotective activities of L615-B7 cells were studied in vivo. T cell functions of cytotoxicity, proliferation and growth factor secretion were detected in vitro.
State Key Laboratory of Experimental Hematology, Institute of Hematology, CAMS and PUMC, Tianjin 300020.
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Liao
D000818:Animals; D018122:B7-1 Antigen / Q000096:biosynthesis*; D019496:Cancer Vaccines / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D006825:Hybridomas; D015458:Leukemia, T-Cell / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D013601:T-Lymphocytes / Q000276:immunology*
D018122:B7-1 Antigen; D019496:Cancer Vaccines