Herpesvirus vectors come of age.
Most human herpesviruses are ubiquitous and are closely associated with a number of severe acute infections and human tumors. Progress in herpesvirus genetics has made members of the herpesvirus family accessible, such that they have become more attractive as gene vectors to be used in the treatment of various diseases, including the prevention of herpesvirus-related afflictions. This review summarizes recent progress and provides a basis for development of new viral and therapeutic strategies.
Department of Gene Vectors, GSF-National Research Center for Environment and Health, Marchioninistrasse 25, D-81377 München, Germany. hammerschmidt@gsf.de
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D000818:Animals; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods; D005822:Genetic Vectors; D006564:Herpesviridae / Q000235:genetics* / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D012449:Safety; D014779:Virus Replication