Experimental ocular acute hypertension-induced chromatinic alterations in astrocytic cells in rat optic nerve.
The effects of ocular acute hypertension experimentally induced on the astrocyte cells of rat have been studied. Evaluation was made of the damage to the chromatin of those cells by means of cytochemical (haematoxylin-eosin) analysis and of the state of fragmentation of the DNA by means of the TUNEL technique as well as the protective effect of the peroxide scavenger, troxol, on those events.
Institute of Ophthalmology, La Sapienza University of Rome.
N
N
Pescosolido
G
G
Scarsella
G
G
Risuleo
M
M
Cristofanilli
C
C
Cardini
G
G
De Feo
E
E
Melchionda
D000208:Acute Disease; D000818:Animals; D001253:Astrocytes / Q000378:metabolism*; D002843:Chromatin / Q000378:metabolism*; D053938:DNA Fragmentation; D020287:In Situ Nick-End Labeling; D007429:Intraocular Pressure; D008297:Male; D008747:Methylcellulose; D009798:Ocular Hypertension / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D009900:Optic Nerve / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D002843:Chromatin; D008747:Methylcellulose