Transcription-associated protein families are primarily taxon-specific.
The mechanisms controlling gene regulation appear to be fundamentally different in eukaryotes and prokaryotes (Struhl (1999) CELL, 98, 1-4). To investigate this diversity further, we have analysed the distribution of all known transcription-associated proteins (TAPs), as reflected by sequence database annotations. Our results for the primary phylogenetic domains (Archaea, Bacteria and Eukaryota) show that TAP families are mostly taxon-specific and very few transcriptional regulators are common across these domains.
Computational Genomics Group, Research Programme, The European Bioinformatics Institute, EMBL Cambridge Outstation, Cambridge CB10 1SD, UK.
R M
RM
Coulson
A J
AJ
Enright
C A
CA
Ouzounis
D019295:Computational Biology; D016208:Databases, Factual; D010802:Phylogeny; D011506:Proteins / Q000145:classification / Q000235:genetics*; D014157:Transcription Factors / Q000145:classification / Q000235:genetics; D014158:Transcription, Genetic
D011506:Proteins; D014157:Transcription Factors