The eotaxins in asthma and allergic inflammation: implications for therapy.
Evidence is emerging for an important role for the CC chemokines, particularly the eotaxins, in the pathogenesis of asthmatic and allergic inflammation. This article reviews the evidence for this involvement and describes new approaches to therapeutics that are evolving as a result.
Department of Respiratory, Medicine and Allergy, Guy's, King's and St Thomas' School of Medicine, 5th Floor Thomas Guy House, Guy's Hospital, London, SE1 9RT, UK. chris.corrigan@kcl.ac.uk
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D000818:Animals; D001249:Asthma / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D054413:Chemokine CCL11; D019742:Chemokines, CC; D016207:Cytokines / Q000096:biosynthesis / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D007249:Inflammation / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors / Q000187:drug effects
C515456:CCL11 protein, human; D054413:Chemokine CCL11; D019742:Chemokines, CC; D016207:Cytokines; D019707:Receptors, Chemokine