[RBC-CR1 genotype polymorphism and RBC immune function in childhood ITP].
OBJECTIVE
To investigate the RBC immune functions in childhood idiopathic thrombocytopenic purpura (ITP).


METHODS
RBC-CR1 polymorphism genotype, RBC immune function and its regulator function were detected in 22 ITP, 30 allergic purpura (AP) and 50 normal children by PCR and Guo Feng's method.


RESULTS
1. There were 18 cases of high expression (82%) and 4 of medium expression (18%) of RBC-CR1 genotypes in the ITP cases. The rate of the medium expression genotype was significantly higher in ITP than that in AP and normal children (P < 0.01). 2. The rates of RBC-C3bRR and RBC-C3bRFER were much lower (P < 0.01), and the rates of RBC-ICR and RBC-C3bRFIR were significantly higher in ITP than those in normal children (P < 0.01). 3. RBC-CR1 genotypes in ITP were correlated negatively with RBC-C3bRR and RBC-C3bRFER (P < 0.05), but positively with RBC-ICR and RBC-C3bRFIR (P < 0.05).


CONCLUSIONS
RBC immune participated in the pathogenesis of ITP.
Dalian Children's Hospital, Dalian 116012.
S
S
Guo
L
L
Zhou
H
H
Wang
D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D005838:Genotype; D006801:Humans; D007223:Infant; D008297:Male; D009154:Mutation; D016133:Polymerase Chain Reaction; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics*; D017463:Receptors, Complement 3b / Q000235:genetics*
D017463:Receptors, Complement 3b