Cytomegalovirus pneumonitis, activated prothrombin time prolongation and subacute thyroiditis after unrelated allogeneic bone marrow transplantation.
A 22-year-old female with acute myeloid leukemia (AML) in complete remission received a conditioning regimen containing antithymocyte globulin for an unrelated bone marrow transplant (BMT). After BMT, the patient suffered from cytomegalovirus (CMV) pneumonitis with markedly high levels of CMV antigenemia, activated prothrombin time (APTT) prolongation, and subacute thyroiditis. Recovery of CD4+ cells was delayed as long as 1 year after BMT. An association between these three episodes and viral infection due to the delayed recovery of CD4+ cells is suggested.
Kawano
C
C
Division of Cell Transplantation and Transfusion, Jichi Medical School, Minamikawachi, Japan.
Muroi
K
K
Akioka
T
T
Izumi
T
T
Kodera
Y
Y
Ozawa
K
K
D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D003586:Cytomegalovirus Infections; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy; D010314:Partial Thromboplastin Time; D011014:Pneumonia / Q000209:etiology* / Q000821:virology*; D012074:Remission Induction; D013968:Thyroiditis, Subacute / Q000209:etiology*; D014184:Transplantation, Homologous / Q000009:adverse effects