An unexpected cause of muscle pain in diabetes.
Diabetic muscle infarction is a rare condition which may present to a rheumatologist. It was first reported in 1965. Two illustrative cases are described here and the mechanisms of pathogenesis discussed. Analysis of the published data, results of the muscle biopsies, and a technetium-99m sestamibi scan suggest that the condition, which occurs against a background of diabetic microangiopathy, can be triggered by an ischaemic event and causes extensive muscle necrosis through hypoxia-reperfusion injury and compartment syndrome.
St Bartholomew's and the Royal London School of Medicine and Dentistry, London, UK.
L
L
Silberstein
K E
KE
Britton
F P
FP
Marsh
M J
MJ
Raftery
D
D
D'Cruz
D001706:Biopsy; D003161:Compartment Syndromes / Q000150:complications; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000628:therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007238:Infarction / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects; D015427:Reperfusion Injury / Q000150:complications; D013848:Thigh; D014057:Tomography, X-Ray Computed