[The informative value of biochemical and cytochemical markers in laboratory animals during field tests].
Field tests (delivery of animals to differently polluted areas having) were carried out. The criterial significance of biochemical and cytochemical tests of bronchoalveolar lavage (BAL) from the animals was defined. The biochemical tests revealed significant changes in total protein, cholesterol, phospholipids, phospholipase A, histamine, serotonin, and others, which indicates metabolic dysfunction in BAL. The findings suggest that the lysosomal cell membranes are disorganized and the permeability of cell mitochondrial membranes is impaired. Thus, analyzing the findings makes it possible to identify the key links of damages and to define the true significance of environmental factors in realizing the mechanisms of pulmonary preabnormality.
Namazbaeva
Z I
ZI
Bazeliuk
L T
LT
Mukasheva
M A
MA
Aĭtkulov
A M
AM
Salimbaeva
B M
BM
D000818:Animals; D001669:Biochemical Phenomena; D001671:Biochemistry; D001992:Bronchoalveolar Lavage Fluid; D002462:Cell Membrane / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004784:Environmental Monitoring; D004785:Environmental Pollutants / Q000378:metabolism*; D006632:Histamine / Q000378:metabolism; D006651:Histocytochemistry; D008168:Lung / Q000378:metabolism*; D008247:Lysosomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D010740:Phospholipases / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors
D004785:Environmental Pollutants; D010743:Phospholipids; D012701:Serotonin; D006632:Histamine; D002784:Cholesterol; D010740:Phospholipases