Meiotic recombination: Making and breaking go hand in hand.
Accurate segregation of homologous chromosomes at the first meiotic division requires the tight coordination of DNA replication, homologous recombination and chromosome organization. Recent studies suggest that the initiation of meiotic recombination is mechanistically coupled to premeiotic DNA replication.
Baudat
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F
Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, Box 97, New York, New York 10021, USA.
Keeney
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S
D004261:DNA Replication; D008540:Meiosis; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics