Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation.
Amgen, One Amgen Center Drive, MS 29-2-B, Thousand Oaks, California 91320, USA.
Y
Y
Luo
B
B
Bolon
S
S
Kahn
B D
BD
Bennett
S
S
Babu-Khan
P
P
Denis
W
W
Fan
H
H
Kha
J
J
Zhang
Y
Y
Gong
L
L
Martin
J C
JC
Louis
Q
Q
Yan
W G
WG
Richards
M
M
Citron
R
R
Vassar
D000544:Alzheimer Disease / Q000201:enzymology* / Q000378:metabolism*; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000172:deficiency* / Q000235:genetics; D002490:Central Nervous System / Q000201:enzymology; D010450:Endopeptidases; D051379:Mice; D018345:Mice, Knockout / Q000235:genetics / Q000378:metabolism; D017933:Peripheral Nervous System / Q000201:enzymology; D010641:Phenotype; D058225:Plaque, Amyloid / Q000201:enzymology
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse