Endometrial cancer: accuracy of the finding of a well differentiated tumor at dilatation and curettage compared to the findings at subsequent hysterectomy.
The objective of this study was to examine the accuracy of the finding of a histologically well differentiated endometrial carcinoma at dilatation and curettage (D & C) prior to hysterectomy. A retrospective multicentric chart review of 137 endometrial cancer patients was conducted, including all patients in whom a well differentiated endometrial carcinoma had been diagnosed by D & C. Histopathologic grading as determined by D & C was compared with the grading established at the final histologic examination after hysterectomy. Seventy-eight percent of all cases in which a well differentiated tumor was diagnosed with D & C were confirmed as well differentiated endometrial carcinomas, whereas 20.4% had to be upgraded as moderately differentiated tumors after evaluation of the hysterectomy specimen. In one case in which a uterine adenocarcinoma was diagnosed by D & C, a well differentiated adenocarcinoma was found to be combined with a carcinosarcoma in the hysterectomy specimen. In order to avoid false findings of a well differentiated tumor, the histologic grade should be confirmed by intraoperative frozen section examination. This is especially important in cases in which surgical staging was not planned initially.
Obermair
A.
A
Department of Gynecology and Obstetrics, University Hospital of Vienna, Vienna;University Hospital of Graz, Graz;General Hospital of Wilhelminenspital, Vienna;General Hospital Salzburg, Salzburg;Hospital Barmherzige Schwestern, Linz;General Hospital Lainz, Vienna;General Hospital Sozialmedizinisches Zentrum Ost/Donauspital, Vienna;General Hospital Rudolftsiftung, Vienna;General Hospital Dornbirn, Dornbirn;Kaiser Franz Josef Hospital, Vienna, and Department of Clinical Pathology/Gynecopathology, University Hospital of Vienna, Vienna, Austria.
Geramou
M.
M
Gücer
F.
F
Denison
U.
U
Graf
A. H.
AH
Kapshammer
E.
E
Medl
M.
M
Rosen
A.
A
Wierrani
F.
F
Neunteufel
W.
W
Frech
I.
I
Speiser
P.
P
Kainz
C.
C
Breitenecker
G.
G