Lactate dehydrogenase activity and insulin and lactate levels at an altitude below sea level (-350 m) compared to those at an altitude above sea level (620 m) after exercise.
This study was designed to investigate the effect of exercise at 350 m below sea level altitude (-350 m) on the serum levels of lactate dehydrogenase (LDH), insulin, and lactate. The study was carried out on ten trained adult males with mean age of 23.3 +/- 3.4 years following a 21-km noncompetitive run. Venous blood was withdrawn from the subjects before exercise and 5 min post exercise. For comparison purposes, a similar study was performed with the same subjects but at 620 m above sea level (+620 m). The results show a significant increase in LDH and lactate levels after exercise only at low altitude (-350 m). Serum insulin levels decreased significantly after exercise at both altitudes. These changes in serum levels of LDH, insulin, and lactate at different altitudes suggest that a type of metabolic adjustment is present that meets energy requirements during exercise.
Department of Biochemistry, School of Medicine, Jordan University of Science and Technology, Irbid, Jordan. mig@just.edu.jo
F
F
El-Migdadi
S Y
SY
Khatib
N
N
Bashir
D000328:Adult; D000531:Altitude; D015444:Exercise; D006801:Humans; D007328:Insulin / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007773:Lactates / Q000097:blood*; D008297:Male
D007328:Insulin; D007773:Lactates; D007770:L-Lactate Dehydrogenase