[Analysis on genetic polymorphism of mtDNA in endurance athletes and sedentary subjects].
OBJECTIVE
To analysis the sequence variation of the origin region (D-loop) of mitochondrial DNA (mtDNA) in elite endurance athletes and sedentary subjects in order to find the genetic markers related with performance.


METHODS
Using a new established PCR method by virtue of tracing sample analysis, the restricted fragment length polymorphism (RFLP) of D-loop in mtDNA was assessed in 76 elite Chinese endurance athletes (EEA), 33 endurance athletes with average-level(GEA) and 20 sedentary control(sc).


RESULTS
There is a significant difference in distribution of the polymorphism in mtDNA D-loop between the EEA and SC(chi 2 = 33.3, P < 0.01).


CONCLUSIONS
The sequence variation of D-loop region of mtDNA in the elite endurance athletes may contribute to the individual difference in aerobic performance and trainability.
Tianjin Research Institute of Sports Medicine, Tianjin 300381.
Q
Q
Chen
L H
LH
Ma
J Q
JQ
Chen
D000328:Adult; D004272:DNA, Mitochondrial / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010807:Physical Endurance / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D013177:Sports
D004272:DNA, Mitochondrial