A flow injection chemiluminescence system for the determination of isoniazid.
A chemiluminescence (CL) flow system is described for the determination of isoniazid based on its enhancement on the chemiluminescence (CL) emission produced upon mixing a hexacyanoferrate(III) solution with an alkaline luminol solution. The system responds linearly to isoniazid concentration in the range 0-1 mg/L with a detection limit (3sigma) of 0.03 microg/L, relative standard deviation (RSD) of 1.2% for 0.1 mg/L isoniazid (n = 11). The system has been successfully applied to the determination of isoniazid in pharmaceutical preparations.
Huang
Y
Y
Institute of Analytical Sciences, Southwest Normal University, Beibei, PR China.
Zhang
Z
Z
Zhang
D
D
Lv
J
J
D000995:Antitubercular Agents / Q000032:analysis* / Q000592:standards; D007538:Isoniazid / Q000032:analysis* / Q000592:standards; D008163:Luminescent Measurements; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000592:standards; D012015:Reference Standards; D012680:Sensitivity and Specificity; D013607:Tablets / Q000032:analysis
D000995:Antitubercular Agents; D004364:Pharmaceutical Preparations; D013607:Tablets; D007538:Isoniazid