Drug delivery via the blood-brain barrier.
The blood-brain barrier forms a buffer against the systemic circulation. Now drugs administered to the brain are shown to be exported by a transporter to act at peripheral sites.
Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences and the Departments of Neurology and Physiology, UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, California 94143-0435, USA. edwards@itsa.ucsf.edu
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D018435:ATP Binding Cassette Transporter, Subfamily B / Q000187:drug effects / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002352:Carrier Proteins / Q000187:drug effects* / Q000378:metabolism; D006801:Humans
D018435:ATP Binding Cassette Transporter, Subfamily B; D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; C095122:multidrug resistance protein 3