Lupus in the family--analysis of a cohort followed from 1978 to 1999.
Familial lupus is recognised but rarely described in mother-daughter case pairs. We describe the prevalence of lupus occurring in the first degree relatives of a cohort of 300 lupus patients under long-term follow-up at a specialised lupus clinic. Three instances of mothers and their daughters who both developed the disease are described in detail to try and ascertain whether there are any particular clinical/serological/genetic factors in common which might explain the phenomenon.
Centre for Rheumatology Bloomsbury, Department of Medicine, University College London, UK. I.Giles@ich.ucl.ac.uk
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D000328:Adult; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology* / Q000235:genetics*; D008297:Male; D015995:Prevalence