Defective cellular trafficking of lacrimal gland aquaporin-5 in Sjögren's syndrome.
Dry eyes and dry mouth are clinical hallmarks of Sjögren's syndrome. We assessed the distribution of aquaporin-5 (AQP5) in lacrimal gland biopsy samples. Healthy controls and patients with Mikulicz's disease or non-Sjögren's syndrome dry eye had the expected apical distribution of AQP5 in lacrimal acinar cells. By contrast, cytoplasmic AQP5 was seen in patients with Sjögren's syndrome. Sodium channel and sodium-potassium ATPase distributions were normal in all groups. These findings show a selective defect in lacrimal gland AQP5 trafficking in Sjögren's syndrome that might contribute to decreased lacrimation and dry eye in these patients.
Tsubota
K
K
Hirai
S
S
King
L S
LS
Agre
P
P
Ishida
N
N
D051402:Aquaporin 5; D020346:Aquaporins / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D007765:Lacrimal Apparatus / Q000378:metabolism*; D008565:Membrane Proteins; D012859:Sjogren's Syndrome / Q000378:metabolism*
C496036:AQP5 protein, human; D051402:Aquaporin 5; D020346:Aquaporins; D008565:Membrane Proteins