Regulation of laminin and COUP-TF expression in extraembryonic endodermal cells.
Laminin expression and the subsequent deposition of a basement membrane by primitive endoderm cells is necessary for early mammalian development. We demonstrate that the transcription factors COUP-TF I and II are up-regulated in primitive endoderm cells faster than LAMB1 and LAMC1, and that either COUP-TF is sufficient to induce expression of these laminin genes.
Department of Human Anatomy and Cell Biology, University of Liverpool, Ashton Street, L69 3GE, Liverpool, UK.
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Murray
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Edgar
D000818:Animals; D051838:COUP Transcription Factor I; D051836:COUP Transcription Factors; D018076:DNA, Complementary / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000096:biosynthesis*; D004622:Embryo, Mammalian / Q000166:cytology; D004707:Endoderm / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D007700:Kinetics; D007797:Laminin / Q000096:biosynthesis*; D051379:Mice; D011987:Receptors, Steroid; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013234:Stem Cells / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D014157:Transcription Factors / Q000096:biosynthesis*; D014162:Transfection; D015854:Up-Regulation
D051838:COUP Transcription Factor I; D051836:COUP Transcription Factors; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D007797:Laminin; C497590:Nr2f1 protein, mouse; D011987:Receptors, Steroid; D014157:Transcription Factors