Extra copies of chromosomes 7, 8, 12, 19, and 21 are recurrent in adamantinoma.
Adamantinoma of long bones is a rare neoplasm predominantly involving the tibia. Cytogenetic studies of adamantinoma are few. Cytogenetic or molecular cytogenetic analysis of four adamantinomas, and a review of eleven cases in the literature reveals extra copies of chromosomes 7, 8, 12, 19, and 21 as recurrent in this neoplasm. Adamantinoma may be confused with a variety of primary and metastatic epithelial and mesenchymal neoplasms. Observation of these aneuploidies may be useful in establishing the diagnosis of adamantinoma.
Departments of Pathology and Microbiology, Center for Human Molecular Genetics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
M
M
Kanamori
C R
CR
Antonescu
M
M
Scott
R S
RS
Bridge
J R
JR
Neff
S S
SS
Spanier
M T
MT
Scarborough
G
G
Vergara
H G
HG
Rosenthal
J A
JA
Bridge
D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000235:genetics* / Q000473:pathology; D000782:Aneuploidy; D002877:Chromosomes, Human; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000235:genetics* / Q000473:pathology; D005360:Fibula / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D012008:Recurrence; D013977:Tibia / Q000473:pathology*