Glycoglycerolipid analogues active as anti-tumor-promoters: the influence of the anomeric configuration.
The in vitro anti-tumor promoting effect of monohexanoates of 2-O-alpha-D-gluco- and galactopyranosyl-sn-glycerol on the 12-O-tetradecanoylphorbol-13-acetate (TPA) induced Epstein-Barr virus early antigen (EBV-EA) activation was evaluated and compared to the potencies of the corresponding beta-anomers. The results show that the inversion of the anomeric configuration from beta to alpha does not seem to significantly influence the activity, which is present, as for the beta-anomers, even at 1x10 mol ratio without any cytotoxicity.
Dipartimento di Chimica e Biochimica Medica, Università di Milano, Via Saldini 50, 20133, Milan, Italy. diego.colombo@unimi.it
D
D
Colombo
F
F
Compostella
F
F
Ronchetti
A
A
Scala
L
L
Toma
H
H
Tokuda
H
H
Nishino
D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D006017:Glycolipids / Q000737:chemistry / Q000494:pharmacology*; D004854:Herpesvirus 4, Human / Q000502:physiology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects
D016588:Anticarcinogenic Agents; D006017:Glycolipids; D013755:Tetradecanoylphorbol Acetate