Quantitative analysis of structure-activity relationship in the acridine series. Part 2: Antitumor 9-thiadiazolo-acridine derivatives.
Synthesis and activity, vs. leukaemia cells of new 9-thiadiazolo acridine derivatives are reported. In addition, electronic properties and molecular structure are correlated with biological activity of these molecules. Results are in agreement with the capability of drugs to intercalate into DNA.
Mrozek
A
A
Technical University of Lódź, Poland.
Karolak-Wojciechowska
J
J
Amiel
P
P
Barbe
J
J
D000166:Acridines / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology; D051379:Mice; D021281:Quantitative Structure-Activity Relationship; D013830:Thiadiazoles / Q000494:pharmacology*
D000166:Acridines; D000970:Antineoplastic Agents; D013830:Thiadiazoles