Hardy-Weinberg quality control.
An efficient test of deviation from Hardy-Weinberg frequencies with one degree of freedom was applied to 44 marker loci in a genome scan, and 7 loci had a significant excess of apparent homozygotes (chi2 (1) > 6) suggestive of typing error. In this example evidence for linkage did not increase when outliers were censored. Statistical quality control is an essential part of genotyping, and the effect of mistyping and map error should be considered in evaluating any genome scan.
Gomes
I
I
Human Genetics, University of Southhampton, Duthie Building, southhampton General Hospital, Tremona Road, Southhampton, UK.
Collins
A
A
Lonjou
C
C
Thomas
N S
NS
Wilkinson
J
J
Watson
M
M
Morton
N
N
D001249:Asthma / Q000235:genetics; D001699:Biometry; D002874:Chromosome Mapping / Q000379:methods / Q000592:standards / Q000706:statistics & numerical data; D005787:Gene Frequency; D008040:Genetic Linkage; D005819:Genetic Markers; D005828:Genetics, Population; D015894:Genome, Human; D005838:Genotype; D006801:Humans; D008957:Models, Genetic; D011786:Quality Control
D005819:Genetic Markers