Synthesis and monoamine transporter affinity of 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicycl.
3Beta-(5-indolyl)-8-azabicyclo[3.2.1]octanes display potent binding affinity for both the dopamine and serotonin transporters, while certain 3beta-(4-(2-pyrrolyl)phenyl)-8-azabicyclo[3.2.1]octanes selectively bind to the serotonin transporter.
Davies
H M
HM
Department of Chemistry, State University of New York at Buffalo, 14260-3000, USA. hdavies@acsu.buffalo.edu
Ren
P
P
Kong
N
N
Sexton
T
T
Childers
S R
SR
D001372:Aza Compounds / Q000138:chemical synthesis; D002352:Carrier Proteins / Q000378:metabolism*; D050483:Dopamine Plasma Membrane Transport Proteins; D007211:Indoles / Q000138:chemical synthesis; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D011758:Pyrroles / Q000138:chemical synthesis; D050486:Serotonin Plasma Membrane Transport Proteins; D013329:Structure-Activity Relationship
D001372:Aza Compounds; D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D007211:Indoles; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D011758:Pyrroles; D050486:Serotonin Plasma Membrane Transport Proteins