Transcription factors and translocations in lymphoid and myeloid leukemia.
Chromosomal translocations involving transcription factors and aberrant expression of transcription factors are frequently associated with leukemogenesis. Transcription factors are essential in maintaining the regulation of cell growth, development, and differentiation in the hematopoietic system. Alterations in the mechanisms that normally control these functions can lead to hematological malignancies. Further characterization of the molecular biology of leukemia will enhance our ability to develop disease-specific treatment strategies, and to develop effective methods of diagnosis and prognosis.
Crans
H N
HN
Department of Pediatrics, UCLA School of Medicine and Jonsson Comprehensive Cancer Center, Los Angeles, CA, USA.
Sakamoto
K M
KM
D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics* / Q000473:pathology; D007951:Leukemia, Myeloid / Q000235:genetics* / Q000473:pathology; D014157:Transcription Factors / Q000502:physiology*; D014178:Translocation, Genetic
D014157:Transcription Factors