Dichloroacetate treatment for severe refractory metabolic acidosis during neonatal sepsis.
We describe a preterm neonate with documented group B Streptococcus sepsis and associated metabolic acidosis whose lactic acidemia was refractory to conventional sodium bicarbonate therapy but responded well to dichloroacetate treatment.
Arnon
S
S
Department of Pediatrics, Meir General Hospital, Kfar-Saba, Israel. h_arnon@gezernet.co.il
Litmanovits
I
I
Regev
R
R
Elpeleg
O
O
Dolfin
T
T
D000140:Acidosis, Lactic / Q000188:drug therapy* / Q000209:etiology; D003999:Dichloroacetic Acid / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D018805:Sepsis / Q000150:complications*; D017693:Sodium Bicarbonate / Q000627:therapeutic use; D013290:Streptococcal Infections / Q000150:complications*
D017693:Sodium Bicarbonate; D003999:Dichloroacetic Acid