Quinine induced coagulopathy--a near fatal experience.
A 67 year old man presented to his local dentist for restorative treatment. He stated he was fit and well and denied taking any medications. When he was given an inferior alveolar nerve block, excessive bleeding was noted at the injection site and the dentist advised the patient see an oral and maxillofacial surgeon. An appointment was made for the patient but he did not attend. Three days later, he presented with evidence of massive deep haemorrhage to the point of airway compromise. He underwent hospital admission, early intubation, intensive care for nine days and hospitalization for six weeks. The cause of his bleeding was a severe thrombocytopoaenia, induced by chronic ingestion of quinine. He was self-medicating with this to relieve muscular cramps. Despite this experience, the patient continued to deny that quinine was the cause of his problem and that he had failed in his obligations to advise the dentist of his drug history. Dentists need to be alert to the risk that patients may not reveal their true medical history. There are, however, obligations on the dentist to ensure the accuracy of information the patient gives and to ensure that patients whom they believe are at risk follow their advice. Teamwork and skillful airway management prevented this patient's demise.
Royal Brisbane Hospital.
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M
Hawthorne
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R
Sim
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CH
Acton
D000368:Aged; D000766:Anesthesia, Dental; D003812:Dentist-Patient Relations; D006406:Hematoma / Q000209:etiology; D006801:Humans; D008297:Male; D008340:Mandibular Nerve; D009060:Mouth Floor / Q000473:pathology; D009120:Muscle Cramp / Q000188:drug therapy; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D009407:Nerve Block; D006472:Oral Hemorrhage / Q000209:etiology; D011803:Quinine / Q000009:adverse effects*; D012651:Self Medication / Q000009:adverse effects; D013921:Thrombocytopenia / Q000139:chemically induced*; D014060:Tongue Diseases / Q000209:etiology
D009125:Muscle Relaxants, Central; D011803:Quinine