Pituitary tumours.
Pituitary tumours are a common type of intracranial neoplasm and, depending on the cell type of origin, have diverse endocrine and reproductive effects. The developmental biology of the different cell types is understood to result from a sequential activation of a cascade of transcription factors, and mutations in these factors result in various forms of hypopituitarism. Tumours in the pituitary gland arise from activation of dominantly acting oncogenes such as gsp, or from loss of function of a series of tumour suppressor genes such as MEN1. Abnormal patterns of DNA methylation may be implicated in the allelic losses that cause tumour suppressor gene silencing. The different clinically recognized types of pituitary tumour are currently treated by medical therapies such as dopamine and somatostatin agonists, surgery or radiotherapy. However, these treatments are not entirely satisfactory and recent advances in gene therapy may offer valuable new therapeutic opportunities for patients with aggressive tumours that fail to respond to traditional approaches.
Davis
J R
JR
Endocrine Sciences Research Group, Faculty of Medicine, University of Manchester, Manchester M13 9PT, UK. julian.davis@man.ac.uk
Farrell
W E
WE
Clayton
R N
RN
D000236:Adenoma / Q000235:genetics / Q000473:pathology; D000818:Animals; D019175:DNA Methylation; D015316:Genetic Therapy; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009857:Oncogenes; D010902:Pituitary Gland / Q000254:growth & development; D010911:Pituitary Neoplasms / Q000453:epidemiology / Q000235:genetics / Q000473:pathology / Q000628:therapy