Interaction of gacyclidine enantiomers with 'non-NMDA' binding sites in the rat central nervous system.
Gacyclidine, a channel blocker of N-methyl-D-aspartate receptors (NMDAR), exhibits potent neuroprotective properties and a low self-neurotoxicity. Preventing its interaction with NMDARs we demonstrate, through the use of its enantiomers, that gacyclidine also interacts with other ('non-NMDA') binding sites. The autoradiographic study showed that these sites displayed a uniform specific binding in the forebrain and a more discrete distribution in the molecular layer of the cerebellum. The 'non-NMDA' binding sites could exert a modulatory control on glutamatergic neurotransmission.
Hirbec
H
H
INSERM U336 DPVSN, Ecole Nationale Supérieure de Chimie, 8, rue de l'école normale, 34296, cedex 5, Montpellier, France.
Kamenka
J M
JM
Privat
A
A
Vignon
J
J
D000818:Animals; D001345:Autoradiography; D001665:Binding Sites / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D002531:Cerebellum / Q000737:chemistry / Q000378:metabolism; D003510:Cyclohexanes / Q000737:chemistry / Q000494:pharmacology*; D053138:Cyclohexenes; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000737:chemistry / Q000494:pharmacology*; D018698:Glutamic Acid / Q000494:pharmacology; D005998:Glycine / Q000494:pharmacology; D008297:Male; D010880:Piperidines / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D013237:Stereoisomerism; D014316:Tritium
D003510:Cyclohexanes; D053138:Cyclohexenes; D018691:Excitatory Amino Acid Antagonists; D010880:Piperidines; D016194:Receptors, N-Methyl-D-Aspartate; D014316:Tritium; D018698:Glutamic Acid; D016291:Dizocilpine Maleate; C070707:gacyclidine; D005998:Glycine