Androgens and female sexuality.
An accumulating body of data indicates that many women experience a cluster of symptoms that are responsive to testosterone treatment and may be due to androgen deficiency. Characteristically, affected women complain of low libido, persistent fatigue, and diminished well-being and are found to have low circulating bioavailable testosterone. Whether the apparent therapeutic effects of testosterone are mediated via the androgen receptor or as a consequence of metabolism to estrogen is not known. Despite the lack of understanding of the mechanism(s) by which testosterone may enhance libido, the prescription of testosterone to women in a variety of formulations is becoming increasingly popular. This article provides an overview of the rationale for testosterone therapy in women, offers a broad definition of androgen deficiency in women based on the clinical experience of the author, and outlines the currently available options and potential risks of testosterone replacement in women.
Davis
S R
SR
Jean Hailes Foundation, 173 Carinish Rd, Clayton, Victoria 3168, Australia. suedavis@netlink.com.au
D000728:Androgens / Q000172:deficiency*; D005260:Female; D006801:Humans; D019529:Sexuality / Q000187:drug effects*; D013739:Testosterone / Q000009:adverse effects / Q000627:therapeutic use*
D000728:Androgens; D013739:Testosterone