Contrast medium-induced pulmonary vascular hyperpermeability is aggravated in a rat climacterium model.
Tominaga K, Kataoka Y, Sendo T, et al. Contrast medium-induced pulmonary vascular hyperpermeability is aggravated in a rat climacterium model. Invest Radiol 2001;36:131-135.


OBJECTIVE
To test whether climacterium influences adverse pulmonary reactions to contrast media, the authors investigated the effect of ioxaglate on pulmonary vascular permeability in ovariectomized rats as a climacterium model.


METHODS
From 7 days after surgery, ovariectomized rats were treated with estradiol valerate or vehicle once per week for 3 weeks. At 28 days after surgery, ioxaglate, an ionic contrast medium, was intravenously injected at 1.5 mL/min in rats. Pulmonary vascular permeability was evaluated by measuring the amount of Evans blue dye in the lung tissue.


RESULTS
Ioxaglate dose-dependently increased pulmonary vascular permeability in sham-operated and ovariectomized rats. Ovariectomized rats showed a 2.6-fold increased aggravation of vascular permeability by ioxaglate 4 g I/kg compared with sham-operated rats. Estradiol valerate (0.2-5.0 mg/kg) dose-dependently blocked ioxaglate-increased vascular permeability in ovariectomized rats.


CONCLUSIONS
These findings suggest that climacterium is included, at least in part, in the risk factors for contrast-induced adverse pulmonary reactions, and this risk is lowered by estrogen replacement therapy.
Department of Hospital Pharmacy, Faculty of Medicine, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka 812-8582, Japan.
K
K
Tominaga
Y
Y
Kataoka
T
T
Sendo
W
W
Furuta
M
M
Niizeki
A R
AR
Oishi
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D002979:Climacteric; D003287:Contrast Media / Q000009:adverse effects* / Q000493:pharmacokinetics*; D005119:Extravasation of Diagnostic and Therapeutic Materials / Q000209:etiology*; D005260:Female; D023421:Models, Animal; D011651:Pulmonary Artery; D051381:Rats; D017208:Rats, Wistar; D012720:Severity of Illness Index
D003287:Contrast Media