Complement and IL-12: yin and yang.
Interleukin 12 (IL-12) is central to the orchestration of cell-mediated immune responses in the innate as well as the adaptive immune system. Recent studies of the pathogenesis of diseases as disparate as measles and asthma have suggested that the complement system, itself at the interface of innate and adaptive immunity, is a biologically relevant regulator of IL-12 production. These data are reviewed here.
Karp
C L
CL
Molecular Immunology Section and Division of Immunobiology, Childrens Hospital Research Foundation, Department of Pediatrics, University of Cincinnati, TCHRF 1566, 3333 Burnet Avenue, Cincinnati, OH 45229-3039, USA. kardc6@chmcc.org
Wills-Karp
M
M
D000818:Animals; D001249:Asthma / Q000276:immunology / Q000503:physiopathology; D003165:Complement System Proteins / Q000276:immunology* / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis*; D008457:Measles / Q000276:immunology / Q000503:physiopathology; D009000:Monocytes / Q000276:immunology* / Q000378:metabolism
D018664:Interleukin-12; D003165:Complement System Proteins