The protease-associated domain: a homology domain associated with multiple classes of proteases.
The non-catalytic part of proteases frequently harbours domains responsible for regulation or targeting. Here, we describe a novel sequence motif conserved in proteins that belong to different protease superfamilies, the subtilases and Zn-containing metalloproteases. The structure of the transferrin receptor, a catalytically inactive member of the latter family, suggests that the protease-associated domain forms a lid structure that covers the active site. In addition to proteases, the domain is also found in two different families of plant vacuolar sorting receptors.
Bioinformatics & Gene Discovery Group, MEMOREC Stoffel GmbH, Stöckheimer, Weg 1, D-50829 Köln, Germany.
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Luo
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Hofmann
D000595:Amino Acid Sequence; D020134:Catalytic Domain; D010450:Endopeptidases / Q000737:chemistry* / Q000378:metabolism; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid
D010450:Endopeptidases