Lead-induced hypertension. III. Increased hydroxyl radical production.
Lead-induced hypertension has previously been shown to be closely associated with an increase in reactive oxygen species in low lead (100 ppm)-treated rats. The present study has attempted to define the specific moiety involved by noting the blood pressure (BP), reactive oxygen species (MDA-TBA), hydroxyl radical, and nitrotyrosine responses to infusion of the reactive oxygen species scavenger dimethylthiourea. Dimethylthiourea, a reputed scavenger of hydroxyl radical, normalized BP and MDA-TBA in the lead-treated rats but had no effect in normal control animals. MDA-TBA, hydroxyl radical, and nitrotyrosine, the tissue end product of peroxynitrite, were reduced to or toward normal by dimethylthiourea. The results, therefore, are consistent with the suggestion that either hydroxyl radical or peroxynitrite may be the reactive species affected by lead.
Division of Nephrology and Hypertension, University of California, Irvine, USA.
Y
Y
Ding
H C
HC
Gonick
N D
ND
Vaziri
K
K
Liang
L
L
Wei
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology*; D017665:Hydroxyl Radical / Q000097:blood / Q000378:metabolism*; D006973:Hypertension / Q000139:chemically induced* / Q000378:metabolism* / Q000503:physiopathology; D007854:Lead / Q000097:blood; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000097:blood
D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D007854:Lead; D017665:Hydroxyl Radical; C002744:3-nitrotyrosine; D014443:Tyrosine; C038983:1,3-dimethylthiourea; D013890:Thiourea