Imaging biochemistry: applications to breast cancer.
The use of magnetic resonance spectroscopy (MRS) to investigate breast tumour biochemistry in vivo is reviewed. To this end, results obtained both from patients in vivo and from tumour extracts and model systems are discussed. An association has been observed between transformation and an increase in phosphomonoesters (PMEs) detected in the 31P MRS spectrum, as well as an increase in choline-containing metabolites detected in the 1H spectrum. A decrease in PME content after treatment is associated with response to treatment as assessed by tumour volume. Experiments in model systems aimed at understanding the underlying biochemical processes are presented, as well as data indicating the usefulness of MRS in monitoring the uptake and metabolism of some chemotherapeutic agents.
Ronen
S M
SM
Institute of Cancer Research, Sutton, Surrey, UK. sabrina@icr.ac.uk
Leach
M O
MO
D000230:Adenocarcinoma / Q000378:metabolism*; D000818:Animals; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000628:therapy; D002460:Cell Line; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D010743:Phospholipids / Q000378:metabolism*; D010759:Phosphorus Isotopes
D010743:Phospholipids; D010759:Phosphorus Isotopes