Chromatin remodeling in development and differentiation.
During development and differentiation, early inductive processes that influence cell fate at a later stage leave marks at distinct gene loci that are maintained through several rounds of mitosis. The structure of chromatin is part of this epigenetic memory that restricts or permits differential expression of genes in descendant cells. Establishing a cell-type-specific chromatin pattern thus predestines future cell differentiation and deters cell-lineage infidelity, as it often occurs during neoplastic transformation. As such, understanding the dynamics and mechanisms underlying chromatin remodeling has been a major focus of recent molecular genetic research that holds great promise for biomedical discoveries.
Müller
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Max-Delbrück-Center for Molecular Medicine, Robert-Rössle-Str. 10, 13092, Berlin, Germany. christine.mueller@mdc-berlin.de
Leutz
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D000818:Animals; D002454:Cell Differentiation; D019070:Cell Lineage; D002843:Chromatin / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure*; D005786:Gene Expression Regulation; D018507:Gene Expression Regulation, Developmental; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000235:genetics / Q000378:metabolism
D002843:Chromatin