Photocleavage of DNA by 4'-bromoacetophenone analogs.
4'-Bromoacetophenone analogs, which are able to generate monophenyl radicals capable of hydrogen atom abstraction, were investigated as possible photoinducible DNA cleaving agents. The potential of 4'-bromoacetophenone as a possible new DNA cleaver is explored. Pyrrolecarboxatmid conjugated 4'-bromoacetophenones, in particular, DNA cleaving activity and sequence-selectivity on the contiguous AT base pair sites.
Jeon
R
R
College of Pharmacy, Sookmyung Women's University, Seoul, Korea. rjeon@sookmyung.ac.kr
Wender
P A
PA
D000098:Acetophenones / Q000737:chemistry / Q000494:pharmacology*; D010777:Photochemistry; D010957:Plasmids / Q000187:drug effects* / Q000378:metabolism; D011758:Pyrroles / Q000737:chemistry / Q000494:pharmacology*
C410763:4'-bromoacetophenone-pyrrolecarboxamine; D000098:Acetophenones; D011758:Pyrroles; C020232:4-bromoacetophenone