[Induction of apoptosis and differentiation in human leukemia cell line HL-60 by synthetic retinoid Ro13-7410].
OBJECTIVE
To investigate the effect of the synthetic retinoid Ro13-7410 on HL-60 cells.


METHODS
Trypan blue exclusion was used to determine viability. Apoptosis was assessed by cell morphology and PCD-assay-kit. Differentiation was assessed by morphology and NBT reduction.


RESULTS
Incubation of the HL-60 cells with 10(-6)-10(-8) mol/L Ro14-7410 resulted in the suppression of cell growth, the induction of cell apoptosis and differentiation.


CONCLUSIONS
Ro13-7410 suppressed HL-60 cell growth mainly via induction of apoptosis.
Liu
X
X
Department of Hematology, First Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400016.
Lou
L
L
Jiang
J
J
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D018922:HL-60 Cells / Q000473:pathology; D006801:Humans
D000970:Antineoplastic Agents