Activity-dependent modification of inhibitory synapses in models of rhythmic neural networks.
The faithful production of rhythms by many neural circuits depends critically on the strengths of inhibitory synaptic connections. We propose a model in which the strengths of inhibitory synapses in a central pattern-generating circuit are subject to activity-dependent plasticity. The strength of each synapse is modified as a function of the global activity of the postsynaptic neuron and by correlated activity of the pre- and postsynaptic neurons. This allows the self-assembly, from random initial synaptic strengths, of two cells into reciprocal oscillation and three cells into a rhythmic triphasic motor pattern. This self-assembly illustrates that complex oscillatory circuits that depend on multiple inhibitory synaptic connections can be tuned via simple activity-dependent rules.
Soto-Treviño
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Volen Center and Biology Department, Brandeis University, Mail Stop 013, 415 South Street, Waltham, Massachusetts 02454-9110, USA.
Thoroughman
K A
KA
Marder
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E
Abbott
L F
LF
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003445:Crustacea / Q000166:cytology / Q000502:physiology; D017952:Ganglia, Invertebrate / Q000166:cytology / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology; D010507:Periodicity; D013569:Synapses / Q000502:physiology*