A preliminary trial of serratiopeptidase in patients with carpal tunnel syndrome.
OBJECTIVE
This study was planned to assess the response of serratiopeptidase in patients with carpal tunnel syndrome (CTS).


METHODS
Twenty patients with CTS were evaluated clinically. After baseline electrophysiological studies, these patients were given serratiopeptidase 10 mg twice daily with initial short course of nimesulide. Clinical and electrophysiological reassessment was done after 6 weeks.


RESULTS
Mean age was 43.9 years with male to female ratio of 1:2.33. Sixty five percent cases showed significant clinical improvement which was supported by significant improvement in electrophysiological parameters. Recurrence was reported in four cases. No significant side effect was observed.


CONCLUSIONS
Serratiopeptidase therapy may proved to be a useful alternative mode of conservative treatment. Larger study may be further helpful to establish the role of serratiopeptidase in CTS.
Dept. of Neurology, SMS Medical College and Hospital, Jaipur.
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Panagariya
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Sharma
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002349:Carpal Tunnel Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D004359:Drug Therapy, Combination; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D012720:Severity of Illness Index; D017678:Sex Distribution; D013449:Sulfonamides / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D010447:Peptide Hydrolases; C022640:serratiopeptidase; C012655:nimesulide