Activation of metabotropic glutamate receptors induces gamma frequency oscillations in the rat dentate gyrus in vivo.
Activation of mGluRs has previously been reported to cause beta/gamma frequency oscillations in CA1 hippocampal slices. The present study reveals that pharmacological activation of mGluRs in vivo induces dentate EEG oscillations at the low end of the gamma frequency range, with peak activity just below 30 Hz.
Martin
S J
SJ
Department of Neuroscience, University of Edinburgh, Crichton Street, Edinburgh EH8 9LE, UK. stephen.martin@ed.ac.uk
D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D003515:Cycloleucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D018891:Dentate Gyrus / Q000187:drug effects / Q000502:physiology*; D004569:Electroencephalography; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051381:Rats; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013997:Time Factors
D001565:Benzoates; D018691:Excitatory Amino Acid Antagonists; D018094:Receptors, Metabotropic Glutamate; D003515:Cycloleucine; C036361:1-amino-1,3-dicarboxycyclopentane; C079694:alpha-methyl-4-carboxyphenylglycine; D005998:Glycine