[Modern drug development by molecular- and cell-biological methods].
V79 cells have been genetically modified for metabolism functions of humans in drug metabolism and metabolic activation of chemicals. All V79 constructs together form the V79 Cell Battery by which GenPharmTox BioTech AG, Tutzing, Germany, is capable of checking drug metabolism early on during preclinical drug development with immediate relevance for the clinical testing of drugs. It is impossible to obtain those data from animal testing. Therefore, the intrinsic problems in extrapolating data generated from animal testing to humans has been circumvented.
Technische Universität München und GenPharmTox BioTech AG, D-Martinsried. doehmer@lrz.tum.de
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D000826:Animal Testing Alternatives; D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods; D002460:Cell Line; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism
D004364:Pharmaceutical Preparations