Residual HIV-1 RNA in blood plasma of patients taking suppressive highly active antiretroviral therapy.
Residual HIV-1 disease remains in the vast majority of patients treated with even the most intensive highly active antiretroviral therapy (HAART). There are at least two well-described molecular mechanisms for HIV-1 persistence in these patients. These include proviral latency in resting CD4+ T-cells, as well as 'cryptic' residual viral replication. As well, potential sanctuary sites, including the brain and testes, may be important areas which will hinder HIV-1 eradication attempts. It is not clear whether other sites of HIV-1 persistence, including tissue-bound infected monocytes/macrophages, may also be involved in residual HIV-1 disease during virally-suppressive HAART.
Center for Human Virology, Department of Medicine, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107, USA. roger.j.pomerantz@mail.tju.edu
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D019380:Anti-HIV Agents / Q000627:therapeutic use*; D015497:HIV-1; D006801:Humans; D010949:Plasma / Q000737:chemistry / Q000821:virology; D012367:RNA, Viral / Q000097:blood*
D019380:Anti-HIV Agents; D012367:RNA, Viral