Beta-D-glycosylamidines: potent, selective, and easily accessible 1-glycosidase inhibitors.
Beta-D-glycosylamidines, in which a glycon is connected via an N-glycoside linkage with a substituted amidine (aglycon), were synthesized in two steps from the corresponding sugars and served as stable and potent beta-glycosidase inhibitors with high selectivity according to the glycon- and alpha, beta-specificities of the enzymes.
Institute for Chemical Research, Kyoto University, Uji, Kyoto, Japan.
W
W
Guo
J
J
Hiratake
K
K
Ogawa
M
M
Yamamoto
S J
SJ
Ma
K
K
Sakata
D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors*
D000578:Amidines; D004791:Enzyme Inhibitors; D001617:beta-Glucosidase