[Neurotransplantation of the fetal tissue and compensatory-restorative processes in the recipient nervous system].
Last years the allogenic neurografting starts to be use in clinic for the treatment of some diseases connected with organic and functional disorders of CNS. This review is devoted to analysis of the literature data and the results of own investigations about the influence of the immature nervous tissue grafts of the different genesis on the compensatory-restorative processes in the central nervous system of mammalian recipients with different models of nervous diseases, mainly the brain traumas. Besides it, the physiological-active substances of developmental brain, the donor materials alternative to allogenic solid and suspensions grafts, the ways to prevent the xenogenic nervous tissue rejection without immune suppressive therapy were analyze. The conception about mechanisms of neurografts influence on the recipient brain was suggested.
Instutute of Higher Nervous Activity and Neurophysiology Russian Academy of Sciences.
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Loseva
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism / Q000502:physiology* / Q000601:surgery; D001930:Brain Injuries / Q000601:surgery / Q000628:therapy; D016380:Brain Tissue Transplantation; D017690:Cell Transplantation; D004195:Disease Models, Animal; D004622:Embryo, Mammalian; D016332:Fetal Tissue Transplantation; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D009417:Nerve Tissue / Q000637:transplantation*; D009422:Nervous System Diseases / Q000601:surgery / Q000628:therapy*; D012038:Regeneration; D014184:Transplantation, Homologous