Translating basic aging research into geriatric health care.
Aging processes are amenable to molecular genetic analyses. Two aspects of such research have been selected for discussion in this paper because of current great interest and their relevance to human aging. Studies on telomeres have revealed new insights on the control of cellular replicative senescence and provided a means to extend the cell's life span during in vitro cultivation. Emerging studies on genetic biomarkers have identified genes that appear to be associated with longevity or with risk factors for aging-related diseases, and raised considerations of ways to reduce disease expression. An interchange between basic scientists and clinicians would encourage new thoughts on the feasibility of translating these fundamental studies into interventions that promote healthier longevity.
Resnick Gerontology Center, Albert Einstein College of Medicine and Montefiore Medical Center, 111 East 210th Street, Bronx, NY 10467, USA.
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Hamerman
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Zeleznik
D000368:Aged; D000375:Aging / Q000235:genetics / Q000473:pathology / Q000502:physiology; D002455:Cell Division; D016922:Cellular Senescence; D005819:Genetic Markers; D006293:Health Promotion; D006299:Health Services for the Aged; D006801:Humans; D008136:Longevity / Q000235:genetics; D012106:Research; D012307:Risk Factors; D016615:Telomere / Q000235:genetics / Q000502:physiology
D005819:Genetic Markers