Recovery of peripheral blood cells in irradiated mice pretreated with bacterial extract IRS-19.
The effect of antigenic bacterial lysate IRS-19 on the recovery of blood cells was studied in mice injured by a single dose of 7 Gy irradiation. The preirradiation administration of IRS-19 accelerated the recovery of leukocytes, reticulocytes and platelets in peripheral blood. The recovery of leukocytes 9-14 days after irradiation in protected animals was accompanied by a higher level of band forms of granulocytes as well as activated lymphoid and monocytoid cells.
Department of Cellular and Molecular Biology, Faculty of Science, Safárik University, Kosice, Slovak Republic. fedvox@kosice.upjs.sk
N O
NO
Macková
P
P
Fedorocko
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001419:Bacteria; D001772:Blood Cell Count; D005260:Female; D006098:Granulocytes; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D007958:Leukocyte Count; D007963:Leukocytes, Mononuclear; D051379:Mice; D008810:Mice, Inbred C57BL; D010976:Platelet Count; D017701:Reticulocyte Count; D014916:Whole-Body Irradiation
D000276:Adjuvants, Immunologic; C079233:IRS 19