Genotype distribution of estrogen receptor-alpha gene polymorphisms in Italian women with surgical uterine leiomyomas.
OBJECTIVE
To explore a possible association between estrogen receptor-alpha (ER-alpha) gene polymorphisms and development of uterine leiomyomas.


METHODS
Case-control study.


METHODS
University teaching hospital.


METHODS
119 women with clinically and surgically diagnosed uterine leiomyomas.


METHODS
Therapeutic hysterectomy.


METHODS
Frequency and distribution of ER-alpha gene polymorphisms.


RESULTS
No statistically significant differences between controls and patients in the allele frequency and genotype distribution were found when Pvu II and Xba I restriction polymorphism sites were analyzed separately. When the two ER-alpha gene polymorphisms were analyzed in combination, five major genotypes were recognized in controls or patients; the frequency differed slightly but not significantly between groups.


CONCLUSIONS
The Pvu II and Xba I polymorphisms in the ER-alpha gene do not produce different risks of developing uterine leiomyomas.
University of Florence, Italy.
F
F
Massart
L
L
Becherini
L
L
Gennari
V
V
Facchini
A R
AR
Genazzani
M L
ML
Brandi
D000483:Alleles; D016022:Case-Control Studies; D015252:Deoxyribonucleases, Type II Site-Specific; D047628:Estrogen Receptor alpha; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007044:Hysterectomy; D007558:Italy; D007889:Leiomyoma / Q000235:genetics* / Q000601:surgery; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length; D011960:Receptors, Estrogen / Q000235:genetics*; D014594:Uterine Neoplasms / Q000235:genetics* / Q000601:surgery
D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen; C025580:endodeoxyribonuclease XBAI; C025630:CAGCTG-specific type II deoxyribonucleases; D015252:Deoxyribonucleases, Type II Site-Specific