Reactivation of primary hypertrophic osteoarthropathy by bronchogenic carcinoma.
This paper reports 2 cases of primary hypertrophic osteoarthopathy (PHO) which evolved into secondary hypertrophic osteoarthopathy (SHO) under the influence of bronchogenic carcinoma. The patients had a clinical picture of primary hypertrophic osteoarthropathy but without any signs of disease activity until in the last several months when a malignant bronchopulmonary condition developed. This activated all the symptoms: joint swelling; enlarged fingers and distal forearms and legs; moist palms and soles; unpleasant odour of perspiration; and deeper folds of the forehead and nasolabial furrow. A bone scan showed increased accumulation of the radioisotope in specific regions of the skeleton. To our knowledge, no similar cases have been described in the literature.
Department for Rheumatology, Physical Medicine and Rehabilitation, Sestre Milosrdnice University Hospital, Zagreb, Croatia.
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Jajic
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Grazio
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Nemcic
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Jajic
D002283:Carcinoma, Bronchogenic / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010004:Osteoarthropathy, Primary Hypertrophic / Q000150:complications*; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000209:etiology