Exercise and ovarian steroid hormones: their effects on mitochondrial respiration.
The effect of exercise on mitochondria respiration was studied in gastrocnemius muscle of ovariectomized rats, pseudopregnant rats, and estrous rats. The estrous cycles were followed by vaginal smears. Rats were made pseudopregnant (PSP) by 45 s cervical stimulation with a glass rod on the day of estrous. The treadmill protocol (21 m/min, 10 grade uphill) induced a significant decrease in state 3 oxygen consumption (oxidative phosphorylation) in estrous (0.26 +/- 0.02 vs. 0.49 +/- 0.05 microatoms O min(-1) mg protein(-1)) and ovariectomized rats (0.18 +/- 0.03 vs. 0.40 +/- 0.03 microatoms O min(-1) mg protein(-1)). In contrast, pseudopregnant and progesterone-treated ovariectomized rats did not decrease state 3 nor state 4 respiratory rates. These results show that the effect of exercise on mitochondria respiration does vary according to the hormonal status.
Instituto de Biología y Medicina Experimental-CONICET, Buenos Aires, Argentina.
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Gigli
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Bussmann
D000818:Animals; D019069:Cell Respiration / Q000187:drug effects / Q000502:physiology*; D004967:Estrogens / Q000502:physiology*; D004971:Estrus / Q000502:physiology; D005260:Female; D006003:Glycogen / Q000378:metabolism; D020249:Hormone Replacement Therapy; D019344:Lactic Acid / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000187:drug effects / Q000378:metabolism*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism; D010052:Ovariectomy; D010101:Oxygen Consumption / Q000187:drug effects* / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D011374:Progesterone / Q000008:administration & dosage; D011555:Pseudopregnancy / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014867:Water / Q000378:metabolism
D004967:Estrogens; D014867:Water; D019344:Lactic Acid; D011374:Progesterone; D006003:Glycogen; D008291:Malate Dehydrogenase; D013385:Succinate Dehydrogenase