Linkage and allelic association of chromosome 5 cytokine cluster genetic markers with atopy and asthma associated traits.
Linkage and association of polymorphic markers in the chromosome 5q31-q33 cytokine cluster to atopy and asthma associated phenotypes have been reported by a number of groups. To investigate this region, 29 polymorphic markers were used to genotype a combined set of 233 families. These markers were ordered based upon the genetic data, supplemented by published genetic and physical maps. Significant two-point linkage was observed for asthma (most significant marker IRF1, P = 0.0002) and atopy (CD14SNP, P = 0.0001). Allelic association was observed between D5S463 and atopy (P = 0.002) and the skin prick test index (P = 0.04). The data support the possibility of three asthma/atopy loci in the 5q31-q33 region, each with a relatively small effect.
Asthma Genetics Group, Wellcome Centre for Human Genetics, Henry Wellcome Building for Genomic Medicine, Headington, OX3 7BN, United Kingdom. awalley@well.ox.ac.uk
A J
AJ
Walley
S
S
Wiltshire
C M
CM
Ellis
W O
WO
Cookson
D000483:Alleles; D001249:Asthma / Q000235:genetics*; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D016207:Cytokines / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D008297:Male; D018895:Microsatellite Repeats; D019655:Quantitative Trait, Heritable
D016207:Cytokines; D005819:Genetic Markers