Synthesis and properties of 2-(4-substituted)butyl derivatives of some 2,3-dihydro-1,3-dioxo-1H-pyrrolo[3,4-c]pyridines.
The synthesis of 2-(4-substituted)butyl derivatives of 4-alkoxy-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (10-15) and the results of preliminary pharmacological screening are described in this paper. All the compounds tested showed a strong analgesic action, suppressed spontaneous locomotor activity and prolonged barbiturate sleep. Except 10, all significantly decreased systolic and diastolic blood pressure.
Department of Chemistry of Drugs, Wrocław University of Medicine, Kraków, Poland.
H
H
Sladowska
D
D
Szkatuła
B
B
Filipek
D
D
Maciag
J
J
Sapa
M
M
Zygmunt
D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013874:Thiopental / Q000494:pharmacology
D018712:Analgesics, Non-Narcotic; D001463:Barbiturates; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D011725:Pyridines; D011758:Pyrroles; D013874:Thiopental