Activity and spectrum of BMS 284756, a new des-F (6) quinolone, tested against strains of ciprofloxacin-resistant Gram-positive cocci.
BMS 284756, a novel des-fluoroquinolone with an expanded potency versus Gram-positive pathogens, demonstrated potent activity against a wide range of 3,541 ciprofloxacin-resistant (MIC, > or = 2 microg/ml) Gram-positive cocci. These strains were selected from more than 24,000 isolates gathered as part of the 1999 SENTRY Antimicrobial Surveillance Program. Further clinical development appears warranted.
University of Iowa College of Medicine, Iowa City, Iowa, USA. ronald-jones@ jonesgr.com
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Jones
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Pfaller
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Stilwell
D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D016908:Gram-Positive Bacterial Infections / Q000382:microbiology*; D006095:Gram-Positive Cocci / Q000187:drug effects*; D006801:Humans; D007211:Indoles; D008826:Microbial Sensitivity Tests / Q000379:methods; D015363:Quinolones
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D007211:Indoles; D015363:Quinolones; D002939:Ciprofloxacin; C419689:garenoxacin