Unusual annular erythema associated with myelodysplastic syndrome.
We report a case of unusual annular erythema associated with myelodysplastic syndrome (MDS). A 58-year-old male with MDS developed annular erythema on his back, scaly erythema on the dorsa of hands, and exudative erythema on his eyelids. Histological examination revealed a mononuclear cell infiltrate around vessels and follicles in the mid- to lower dermis. He had no history of treatment with granulocyte-colony-stimulating factor (G-CSF). Serum granulocyte-macrophage-colony-stimulating factor (GM-CSF) level was slightly elevated (5.84 pg/ml, normal < 2.0 pg/ml), whereas other cytokines including G-CSF, IL-6, and IL-8 were within normal limits. Skin manifestations were much improved by systemic mepitiostane, and serum GM-CSF level returned to normal levels.
Yamamoto
T
T
Department of Dermatology, Tokyo Medical and Dental University, School of Medicine, Tokyo, Japan. yamamoto.derm@med.tmd.ac.jp
Soejima
K
K
Yokozeki
H
H
Koyano
T
T
Katayama
I
I
Nishioka
K
K
D000368:Aged; D000732:Androstanols / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use; D004890:Erythema / Q000097:blood / Q000209:etiology / Q000473:pathology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000097:blood / Q000187:drug effects; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000188:drug therapy; D012867:Skin / Q000187:drug effects / Q000473:pathology
D000732:Androstanols; D000970:Antineoplastic Agents; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; C006242:mepitiostane