[Long-term immunologic response in HIV-infected patients with CD4 cell counts </= 50/mm3 when initiating protease inhibitor therapy].
From March to July 1996, 61 patients with CD4<50/mm(3)began a therapy with protease inhibitors. Increase and maintenance of CD4>100/mm(3) was observed in 39/61 patients with a protective effect for occurrence of AIDS or death. This immunological response was correlated with the duration of the virological response. However, 38% of patients with long-term immunological response never had a undetectable viral load.
Service des Maladies Infectieuses et Tropicales, Hôpital Bichat--Claude Bernard, Paris.
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Le Moing
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Eid
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Ecobichon
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Duval
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Longuet
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Elbim
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Brun-Vezinet
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Leport
J L
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Vilde
D018791:CD4 Lymphocyte Count; D018450:Disease Progression; D005500:Follow-Up Studies; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy* / Q000276:immunology* / Q000401:mortality / Q000821:virology; D017320:HIV Protease Inhibitors / Q000276:immunology* / Q000627:therapeutic use*; D006801:Humans; D019469:Indinavir / Q000276:immunology* / Q000627:therapeutic use*; D019438:Ritonavir / Q000276:immunology* / Q000627:therapeutic use*; D019258:Saquinavir / Q000276:immunology* / Q000627:therapeutic use*; D013997:Time Factors; D016896:Treatment Outcome; D019562:Viral Load
D017320:HIV Protease Inhibitors; D019469:Indinavir; D019258:Saquinavir; D019438:Ritonavir