Increased risk for ischaemic events is related to combined RAS polymorphism.
OBJECTIVE
To determine whether the angiotensin converting enzyme (ACE) and the angiotensin II type 1 receptor (AT(1)R A1166C) gene polymorphism interact to increase the risk of ischaemic events, and whether this can be explained by the progression of angiographically defined coronary atherosclerosis.


METHODS
Prospective defined substudy of the lipid lowering regression trial (REGRESS).


METHODS
University hospital.


METHODS
885 male patients with stable coronary artery disease.


METHODS
Incidence of ischaemic events during a two year follow up; serial quantitative coronary arteriography (mean segment diameter and minimum obstruction diameter) at baseline and after two years.


RESULTS
Patients who carried both the ACE-DD and AT(1)R-CC genotype had significantly more ischaemic events during the two year follow up than those carrying other genotype combinations (p = 0.035, Mantel-Haenszel test for linear association). There was no association between the two genotypes and mean segment diameter or minimum obstruction diameter at baseline or after two years.


CONCLUSIONS
The suggestion that ACE-DD and AT(1)R-CC genotypes interact to increase the risk of ischaemic events is confirmed. However, this increased risk was not accompanied by increased progression of angiographically defined coronary atherosclerosis.
van Geel
P P
PP
Department of Cardiology, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands. p.p.geel@med.rug.nl
Pinto
Y M
YM
Zwinderman
A H
AH
Henning
R H
RH
van Boven
A J
AJ
Jukema
J W
JW
Bruschke
A V
AV
Kastelein
J J
JJ
van Gilst
W H
WH
D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D018450:Disease Progression; D005838:Genotype; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D017202:Myocardial Ischemia / Q000453:epidemiology / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000235:genetics*; D012084:Renin-Angiotensin System / Q000235:genetics* / Q000502:physiology; D012307:Risk Factors; D016019:Survival Analysis
D008055:Lipids; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin; D007703:Peptidyl-Dipeptidase A