Three ways to make a vesicle.
Cargo molecules have to be included in carrier vesicles of different forms and sizes to be transported between organelles. During this process, a limited set of proteins, including the coat proteins COPI, COPII and clathrin, carries out a programmed set of sequential interactions that lead to the budding of vesicles. A general model to explain the formation of coated vesicles is starting to emerge but the picture is more complex than we had imagined.
Harvard Medical School, 200 Longwood Avenue, Boston, Massachusetts 02115, USA. kirchhausen@crystal.harvard.edu
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D000818:Animals; D022181:COP-Coated Vesicles / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D002966:Clathrin / Q000737:chemistry / Q000502:physiology*; D020755:Coat Protein Complex I / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D022161:Transport Vesicles / Q000502:physiology*
D002966:Clathrin; D020755:Coat Protein Complex I