Acetyl-L-carnitine enhances Na(+), K(+)-ATPase glutathione-S-transferase and multiple unit activity and reduces lipid peroxidation and lipofuscin concentration in aged rat brain regions.
This study investigated the effects of chronically administered acetyl-L-carnitine (ALC) on sodium potassium adenosine triphosphatase (Na(+), K(+)-ATPase), glutathione-S-transferase (GST), glutathione peroxidase (GPx), multiple unit activity (MUA) and lipid peroxidation (LP) and lipofuscin (LF) concentration in brain regions: cerebral cortex, hippocampus, striatum and thalamus, of 24-month-old rats. The activity of Na(+), K(+)-ATPase and GST was enhanced; that of GPx was unaffected. The MUA was increased while the levels of LP and LF were decreased. These novel data provide new additional evidence concerning the antiaging attributes of ALC.
Neurobiology Laboratory, School of Life Sciences, Jawaharlal Nehru University, 110 067, New Delhi, India.
J
J
Kaur
D
D
Sharma
R
R
Singh
D000108:Acetylcarnitine / Q000494:pharmacology*; D000375:Aging / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000187:drug effects / Q000378:metabolism; D005982:Glutathione Transferase / Q000187:drug effects* / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008062:Lipofuscin / Q000378:metabolism; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000378:metabolism
D008062:Lipofuscin; D018697:Nootropic Agents; D000108:Acetylcarnitine; D005979:Glutathione Peroxidase; D005982:Glutathione Transferase; D000254:Sodium-Potassium-Exchanging ATPase