Expression pattern of the drm/gremlin gene during chicken embryonic development.
The drm gene encodes a cystine knot-containing secreted and cell membrane-associated glycoprotein shown to be an antagonist of BMPs. Drm was recently reported to play a crucial role in limb bud development, by its capacity to bind BMPs. Here, we have studied the expression pattern of drm transcripts during chicken development, by using whole-mount in situ hybridization. We show that, from stage 22HH to stage 26HH, in addition to limb buds, drm is expressed in cephalic neural crest-derived branchial arches I, II and III, in the medio-dorsal lip of the myotome and in the superficial dermatome
Régulations Cellulaires et Oncogénèse, UMR 146 du CNRS, Institut Curie, Centre Universitaire, 91405 Orsay, Cedex, France.
B
B
Bardot
L
L
Lecoin
E
E
Huillard
G
G
Calothy
M
M
Marx
D000818:Animals; D019485:Bone Morphogenetic Proteins; D002642:Chick Embryo; D016207:Cytokines; D004622:Embryo, Mammalian / Q000378:metabolism; D004625:Embryo, Nonmammalian / Q000378:metabolism*; D017403:In Situ Hybridization; D009432:Neural Crest / Q000196:embryology*; D014176:Protein Biosynthesis; D011506:Proteins; D013997:Time Factors
D019485:Bone Morphogenetic Proteins; D016207:Cytokines; C107276:Grem1 protein, rat; D011506:Proteins