Netrin-3 protein is localized to the axons of motor, sensory, and sympathetic neurons.
The netrin family of axon guidance cues has been shown to play a pivotal role in the guidance of a variety of axon projections during embryonic development, both in the vertebrate and invertebrate. While the guidance potential of netrin-1 has been examined in depth in many regions of the developing mouse brain very little information is available on the expression and activity of netrin-3. Here we show that the netrin-3 protein is present on motor neurons and subpopulations of neurons within sensory and sympathetic ganglia. Moreover, significant levels of netrin-3 protein were found to be associated with the axons projecting from these neurons suggesting a role for netrin-3 in axon pathfinding and fasciculation within the peripheral nervous system.
Development and Neurobiology Unit, Walter and Eliza Hall Institute, Post Office Royal Melbourne Hospital, 3050, Victoria, Australia.
C
C
Seaman
H M
HM
Cooper
D000818:Animals; D001369:Axons / Q000378:metabolism*; D001921:Brain / Q000196:embryology*; D007150:Immunohistochemistry; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D000075385:Netrins; D009432:Neural Crest / Q000196:embryology; D009474:Neurons / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution; D012668:Trigeminal Ganglion / Q000196:embryology
D009419:Nerve Tissue Proteins; D000075385:Netrins; C119569:netrin-3