Xath2, a bHLH gene expressed during a late transition stage of neurogenesis in the forebrain of Xenopus embryos.
We have identified a Xenopus bHLH gene, Xath2, which is the homologue of the murine MATH-2/NEX-1 gene, using a functional expression screening approach. Overexpression of this gene in neurula embryos induces the expression of the N-tubulin neuronal marker but does not stimulate the expression of the X-ngnr-1 and NeuroD proneural genes. Expression of Xath2 begins in stage 32 embryos and is restricted to the dorsal telencephalon. Within the neuroepithelium of the dorsal telencephalon, Xath2 expression is detected in postmitotic cells located more laterally than those expressing several other related bHLH neuronal regulators.
Laboratoire d'Embryologie Moléculaire, IBMM, Université Libre de Bruxelles, Rue des Profs. Jeener et Brachet 12, B-6041, Gosselies, Belgium.
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Taelman
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Opdecamp
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Avalosse
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Ryan
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Bellefroid
D000595:Amino Acid Sequence; D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D001973:Bromodeoxyuridine / Q000378:metabolism; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D004625:Embryo, Nonmammalian; D015723:Gene Library; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics*; D009474:Neurons / Q000378:metabolism; D016548:Prosencephalon / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014018:Tissue Distribution; D014157:Transcription Factors / Q000096:biosynthesis*; D014404:Tubulin / Q000378:metabolism; D014981:Xenopus / Q000196:embryology*; D029867:Xenopus Proteins
D051792:Basic Helix-Loop-Helix Proteins; D001973:Bromodeoxyuridine; D018076:DNA, Complementary; D009419:Nerve Tissue Proteins; D014157:Transcription Factors; D014404:Tubulin; D029867:Xenopus Proteins; C110701:Neurod6 protein, mouse; C093546:neurod6 protein, Xenopus; C101907:neurogenin, Xenopus; C093564:Neurogenic differentiation factor 1