Ocular biomaterials and implants.
The maintenance of vision is a key determinant of healthy ageing. This has been facilitated over recent decades by the development of a wide range of implants and biomedical devices to correct the functional deficiencies of disease, age and ocular trauma. This brief overview provides an insight into the structure of this unique organ, the major physiological functions of the component tissues and the present state of the art with respect to modern ocular implants. The review focuses primarily on the existing limitations of existing ocular biomaterials used in the fabrication of contact lenses, intraocular lenses, glaucoma filtration implants, keratoprostheses, intracorneal implants, scleral buckles and viscoelastic replacement agents. The challenge of improving ocular compatibility and ensuring the longevity of indwelling ocular devices is addressed along with the need to improve the physicochemical and mechanical properties of existing ocular biomaterials.
Biomedical Materials Research Group, School of Pharmacy & Biomolecular Sciences, University of Brighton, UK. a.w.lloyd@brighton.ac.uk
A W
AW
Lloyd
R G
RG
Faragher
S P
SP
Denyer
D000818:Animals; D001672:Biocompatible Materials; D003261:Contact Lenses; D016503:Drug Delivery Systems; D005123:Eye / Q000033:anatomy & histology; D005137:Eye, Artificial; D020327:Glaucoma Drainage Implants; D006801:Humans; D007910:Lenses, Intraocular; D009799:Ocular Physiological Phenomena; D019736:Prostheses and Implants; D012591:Scleral Buckling; D012827:Silicone Oils
D001672:Biocompatible Materials; D012827:Silicone Oils