[The significance of endothelin-1 in regulation of the circulatory system in hemorrhage shock].
Endothelin-1 (ET1), a 21-amino acid polypeptide, produced mainly in endothelial cells is the most potent mammalian vasoconstrictor peptide known. Haemorrhagic hypotension is accompanied by the increase in plasma ET1 concentration. The significance of this effect, however, is not clear. This paper reviews the causes of the rise in ET1 plasma concentration and the role of ET1 in cardiovascular regulation in haemorrhagic shock.
Katedra i Zakład Fizjologii Slaskiej Akademii Medycznej w Katowicach.
J
J
Jochem
J
J
Jośko
D000818:Animals; D019332:Endothelin-1 / Q000502:physiology*; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D012771:Shock, Hemorrhagic / Q000503:physiopathology*
D019332:Endothelin-1