Donor age-related differences in PBPC mobilization with rHuG-CSF.
BACKGROUND
Data on the administration of rHuG-CSF to normal donors <18 years old are very limited.


METHODS
The results of rHuG-CSF administration to 61 donors <18 years old (Group A) were retrospectively evaluated and compared with results from 353 donors > or = 18 years old (Group B) who are included in the Spanish National Donor Registry. The mean age (range) in Group A and B was 14 (1-17) and 38 (18-71) years, respectively (p<0.001). The mean dose of rHuG-CSF was 10 microg per kg per day (range, 9-16) during a mean of 5 days (range, 4-6). Central venous access was placed more frequently in younger donors (25% vs. 6%; p<0.001).


RESULTS
The mean number of CD34+ cells collected was 7.6 and 6.9 x 10(6) per kg of donor's body weight in Group A and B, respectively. Fifty-six percent of Group A donors needed only one apheresis to achieve > or = 4 x 10(6) CD34+ cells per kg versus 39 percent of Group B donors (p = 0.01). Side effects were more common in Group B (71% vs. 41%; p<0.001).


CONCLUSIONS
The administration of rHuG-CSF to donors <18 years old leads to CD34+ cell mobilization in a pattern similar to that observed in adults. Greater age was associated with a more frequent requirement for more than one apheresis to achieve a similar number of CD34+ cells.
de La Rubia
J
J
Spanish Group of Allogeneic Peripheral Blood Stem Cell Transplantation, La Fe Hospital, Valencia, Spain. delarubia_jav@gva.es
Díaz
M A
MA
Verdeguer
A
A
Pascual
M J
MJ
Arbona
C
C
Arrieta
R
R
Brunet
S
S
Bargay
J
J
Martínez
C
C
Espigado
I
I
Serrano
D
D
Alegre
A
A
de Arriba
F
F
de La Serna
J
J
Zamora
C
C
Benlloch
L
L
Sanz
M A
MA
D000293:Adolescent; D000328:Adult; D000375:Aging / Q000502:physiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D019650:Hematopoietic Stem Cell Mobilization; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor