DDT -- a novel domain in different transcription and chromosome remodeling factors.
Homology-based sequence analyses have revealed the presence of a novel domain (DDT) in bromodomain PHD finger transcription factors (BPTFs), chromatin remodeling factors of the BAZ-family and other putative nuclear proteins. This domain is characterized by a number of conserved aromatic and charged residues and is predicted to consist of three alpha helices. Recent studies indicate a likely DNA-binding function for the DDT domain.
Doerks
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European Molecular Biology Laboratory, 69012 Heidelberg, Germany. doerks@EMBL-HEIDELBERG.DE
Copley
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Bork
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D000595:Amino Acid Sequence; D002875:Chromosomes; D018398:Homeodomain Proteins / Q000737:chemistry; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors / Q000737:chemistry*
D018398:Homeodomain Proteins; D014157:Transcription Factors