[Effect of sodium fluoride mouth rinses containing xylitol and sorbitol on the number of Streptococcus mutans from human saliva].
The objective of this study was to assess the effect of 0.05% sodium fluoride solutions containing 2.5% or 12.5% xylitol on the number of Streptococcus mutans in the human mouth. Fifty boys between 8 and 16 years of age participated in this double-blind crossover study. Of the original 50 boys, 33 finished the study. Participants were randomly divided into four groups. The following solutions were employed: placebo solution; 0.05% sodium fluoride solution; 0.05% sodium fluoride + 2.5% xylitol + 2% sorbitol; 0.05% sodium fluoride + 12.5% xylitol + 2% sorbitol. Each solution was used for a 28-day period (20 mL/day, twice a day), with a 10-day washout period between solutions. There were no significant differences (P = 0.32) between the two xylitol-containing solutions (2.5% vs. 12.5%) concerning the number of Streptococcus mutans. However, there was a significant difference between these two xylitol-containing solutions and the sodium fluoride and placebo solutions (P < 0.001). Our results suggest that the 0.05% sodium fluoride solutions containing either 2.5% or 12.5% xylitol caused a significant reduction in the number of Streptococcus mutans.
Universidade Estadual de São Paulo (UNESP), Faculdade de Odontologia de Araraquara, Mestrado em Odontopediatria, Araraquara, SP, Brasil. nilzavalor@yahoo.com
N C
NC
Gonçalves
A
A
Valsecki Júnior
S L
SL
Salvador
G C
GC
Bergamo
D000293:Adolescent; D002648:Child; D015169:Colony Count, Microbial; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D009067:Mouthwashes / Q000494:pharmacology*; D012463:Saliva / Q000382:microbiology*; D012969:Sodium Fluoride / Q000494:pharmacology*; D012996:Solutions; D013012:Sorbitol / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000302:isolation & purification*; D014993:Xylitol / Q000494:pharmacology*
D009067:Mouthwashes; D012996:Solutions; D013012:Sorbitol; D012969:Sodium Fluoride; D014993:Xylitol