Pharmacologic activities of aged garlic extract in comparison with other garlic preparations.
We investigated the pharmacologic activities of four garlic preparations, raw garlic juice (RGJ), heated garlic juice (HGJ), dehydrated garlic powder (DGP) and aged garlic extract (AGE). The study used three animal models, i.e., testicular hypogonadism (hypospermatogensis and impotence) induced by warm water treatment, intoxication of acetaldehyde and growth of inoculated tumor cells. RGJ was found to be effective only in recovery of testicular function. The efficacy of HGJ was observed in three models; however, it did not improve impotence. DGP was effective in recovery of spermatogenesis and stimulated acetaldehyde detoxification. Significant beneficial effects of AGE were found in all three models. Although all four garlic preparations significantly enhanced natural killer (NK) and killer cell activities of the spleen cells of tumor-bearing mice, only AGE and HGJ inhibited the growth of inoculated tumor cells. These results suggest that different types of garlic preparations have different pharmacologic properties, and among the four garlic preparations studied, AGE could be the most useful garlic preparation.
Institute for OTC Research, Wakunaga Pharmaceutical Company, Koda-cho, Takata-gun, Hiroshima 739-1195, Japan.kasuga_s@wakunaga.co.jp
S
S
Kasuga
N
N
Uda
E
E
Kyo
M
M
Ushijima
N
N
Morihara
Y
Y
Itakura
D000079:Acetaldehyde / Q000633:toxicity; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003681:Dehydration; D004195:Disease Models, Animal; D005511:Food Handling / Q000379:methods*; D005737:Garlic / Q000627:therapeutic use*; D006358:Hot Temperature / Q000009:adverse effects; D007006:Hypogonadism / Q000188:drug therapy*; D007694:Killer Cells, Natural / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011041:Poisoning / Q000517:prevention & control; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013737:Testis / Q000187:drug effects* / Q000502:physiology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010936:Plant Extracts; D000079:Acetaldehyde