Characterization of cross-reacting allergens in mango fruit.
BACKGROUND
Allergic reactions to mango fruit have become increasingly important. A cross-reaction between mango fruit, various other foods, and respiratory allergens has been assumed but not investigated until now.


METHODS
The sera of nine patients were used to characterize cross-reacting allergens in mango fruits by EAST inhibition and immunoblot inhibition.


CONCLUSIONS
EAST inhibition and immunoblot inhibition demonstrated that cross-reactions between mango fruits, mugwort pollen, birch pollen, celery, and carrot are based on allergens related to Bet v 1 and Art v 1, the major allergens of birch and mugwort pollen, respectively.
Paschke
A
A
University of Hamburg, Institute of Biochemistry and Food Chemistry, Germany.
Kinder
H
H
Zunker
K
K
Wigotzki
M
M
Steinhart
H
H
Wessbecher
R
R
Vieluf
I
I
D000293:Adolescent; D000328:Adult; D000368:Aged; D000485:Allergens / Q000009:adverse effects*; D000953:Antigens, Protozoan / Q000009:adverse effects*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D005638:Fruit / Q000009:adverse effects*; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D008222:Lymphokines / Q000037:antagonists & inhibitors; D008297:Male; D008875:Middle Aged; D011058:Pollen / Q000009:adverse effects / Q000033:anatomy & histology; D029584:Prostatic Secretory Proteins
D000485:Allergens; D000953:Antigens, Protozoan; D008222:Lymphokines; D029584:Prostatic Secretory Proteins; C063362:QF116 antigen, Plasmodium falciparum; C043076:beta-microseminoprotein; C013059:immunoglobulin-binding factors; D007073:Immunoglobulin E