CEPU-1 expression in the early embryonic chick brain.
We describe the expression pattern of CEPU-1, a cell adhesion molecule of the immunoglobulin superfamily, in the early chick embryo brain. An initially broad domain of expression, encompassing forebrain, midbrain and anterior hindbrain, is subsequently narrowed down to a ring-shaped domain at the midbrain-hindbrain boundary, co-localizing precisely with the expression of Wnt1 at the isthmus. In addition, CEPU-1 is expressed in the dorsal aspect of rhombomere 4 and its emigrating neural crest cells. Later in development, we also find CEPU-1 expression in other parts of the developing nervous system such as sensory ganglia and in the ventral aspect of forebrain, midbrain and hindbrain.
Jungbluth
S
S
MRC Centre for Developmental Neurobiology, King's College London, Guy's Campus, SEl lUL, London, UK.
Phelps
C
C
Lumsden
A
A
D000818:Animals; D030161:Avian Proteins; D001921:Brain / Q000196:embryology*; D002642:Chick Embryo; D003001:Cloning, Molecular; D020869:Gene Expression Profiling; D007136:Immunoglobulins / Q000096:biosynthesis*; D017403:In Situ Hybridization; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D008636:Mesencephalon / Q000378:metabolism; D009420:Nervous System / Q000196:embryology; D009432:Neural Crest / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D016548:Prosencephalon / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis; D012249:Rhombencephalon / Q000378:metabolism; D013997:Time Factors; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins
D030161:Avian Proteins; D007136:Immunoglobulins; D008562:Membrane Glycoproteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins; C102493:neural CEPU-1 protein, chicken