The correlations of clinicopathologic features, hormone receptor level with the prognosis of breast cancer: report of 308 cases in elderly women.
OBJECTIVE
This study analyses the clinicopathologic features and hormone receptor level of breast cancer in aged patients (> or = 60 years) and explores the related factors of the prognosis.


METHODS
For all patients, the clinical data and pathologic data were reviewed retrospectively. Follow-up data were available. Of the 308 cases, tumor specimens in 130 patients were subjected to hormone receptor analysis by a dextran-coated charcoal technique.


RESULTS
Of the 308 cases, 82 cases were in stage I, 147 cases in stage II, 66 cases in stage III, and 13 cases in stage IV. Metastatic rate (axillary lymph nodes) was 35.7%. The overall postoperative 5- and 10-year survival rates were 70.8% and 50.5%, respectively. Estrogen receptor and progesterone receptor positive rates were 66.9% and 40.0%, respectively. The survival rate was decreased with the increasing grade of TNM (P < 0.01). The mortality rate of the breast cancer was related to the clinical stage and the hormone receptor level (P < 0.05).


CONCLUSIONS
There was a relatively good prognosis in this series. The size of tumor, number of metastatic nodes and hormone receptor level were related to the prognosis.
School of Oncology, Beijing Medical University, Beijing 100036.
Y
Y
Shi
L
L
He
Y
Y
Chen
J
J
Li
D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D000368:Aged; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D018276:Carcinoma, Medullary / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008408:Mastectomy / Q000379:methods; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism; D012189:Retrospective Studies; D015996:Survival Rate
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone