Reanalysis of multislice (1)H MRSI in amyotrophic lateral sclerosis.
The goal of this work was to reexamine previously published (1) brain spectroscopy data of abnormal metabolite ratios in amyotrophic lateral sclerosis (ALS). Toward this goal, (1)H MR spectroscopic imaging data from 10 ALS and nine control subjects were reanalyzed using improved data analysis techniques, including automated curve fitting and tissue-volume correction. In the motor cortex of ALS, N-acetyl aspartate (NAA) was 23% (P = 0.004) lower than in controls, and in the posterior internal capsule of ALS choline compounds (Cho) were 20% (P = 0.02) higher. This demonstrates that the metabolite ratio changes in ALS were due to NAA loss in the motor cortex (as expected) and Cho increase in the posterior internal capsule (not expected). Magn Reson Med 45:513-516, 2001.
DVA Medical Center and Department of Radiology, University of California-San Francisco, San Francisco, California 94121, USA. nschuff@itsa.ucsf.edu
N
N
Schuff
W D
WD
Rooney
R
R
Miller
D F
DF
Gelinas
D L
DL
Amend
A A
AA
Maudsley
M W
MW
Weiner
D000328:Adult; D000368:Aged; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000473:pathology*; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D020772:Internal Capsule / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology; D016472:Motor Neuron Disease / Q000175:diagnosis*; D012016:Reference Values
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline