Synthesis and structure-activity relationship of diarylamide derivatives as selective inhibitors of the proliferation of human coronary artery smooth muscle cells.
A series of diarylamide derivatives were synthesized and evaluated for their inhibitory activities against human coronary artery smooth muscle cells (SMCs) and human coronary artery endothelial cells (ECs). Compound 2w was superior to the lead compound, Tranilast, in terms of the potency of the activity and cell selectivity.
Pharmaceuticals & Biotechnology Laboratory, Japan Energy Corporation, Saitama, Japan.
H
H
Ogita
Y
Y
Isobe
H
H
Takaku
R
R
Sekine
Y
Y
Goto
S
S
Misawa
H
H
Hayashi
D000577:Amides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy; D003331:Coronary Vessels / Q000166:cytology / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000577:Amides