The use of vigabatrin in infantile spasms in Asian children.
BACKGROUND
The use of adrenocorticotrophic hormone (ACTH) and prednisolone in the management of infantile spasms has been well established, but is associated with significant morbidity and cannot be used as long-term medication. Since the introduction of vigabatrin, results have been promising with suggestions currently that it should be used as first-line management of infantile spasms.


OBJECTIVE
The aim of this study was to establish the efficacy, tolerability and problems associated with the use of vigabatrin, in Asian children with infantile spasms.


METHODS
Eighteen local Asian patients with infantile spasms were given vigabatrin, in 8 as first-line monotherapy and in 10 patients as add-on therapy to pre-existing anti-convulsants.


RESULTS
Thirty-nine per cent (7/18) showed 100% suppression of seizures at 2 weeks and 50% (9/18) showing complete suppression of seizures at 4 weeks after starting therapy. There was however, a high relapse rate (56%) in complete responders within the first 6 months of therapy. This was probably due to a lower maintenance dose in the patients, as those who relapsed were on an average dose of 59 mg/kg/day at the time of relapse and responded to a stepped up dose of 83 mg/kg/day. Vigabatrin was well tolerated and only 2 patients developed somnolence and irritability.


CONCLUSIONS
A dose of at least 70 mg/kg/day may be necessary to achieve adequate control and yet avoid the common adverse affects of vigabatrin.
Department of Paediatrics, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.
S K
SK
Tay
H T
HT
Ong
P S
PS
Low
D000927:Anticonvulsants / Q000008:administration & dosage*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005006:Ethnicity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D012189:Retrospective Studies; D012720:Severity of Illness Index; D012846:Singapore; D013036:Spasms, Infantile / Q000175:diagnosis / Q000188:drug therapy* / Q000208:ethnology; D016896:Treatment Outcome; D020888:Vigabatrin / Q000008:administration & dosage*
D000927:Anticonvulsants; D020888:Vigabatrin