[Use of antioxidants and trimetazidine in preparation of patients with ischemic heart disease for coronary angiography].
Lipid peroxidation, cell stability, lipid spectrum, conjunctival microcirculation, levels of ceruloplasmin and myoglobin were studied in 107 males with ischemic heart disease before and after coronaroangiography by M. Judkins (CAG). It was found that CAG provokes oxidative stress, promotes membranodestructive processes, dyslipidemia and circulation disorders in the bulbar conjunctive. Preventive (3 days before CAG) administration of alpha-tocopherol or emoxipin proved cardioprotective. The highest cytoprotective effect was produced by trimetasidine given 10 days before the procedure.
Logacheva
I V
IV
Leshchinskiĭ
L A
LA
Romanova
Z D
ZD
Gaĭsin
I R
IR
Perevalov
A P
AP
Karbasnikova
G V
GV
D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use*; D017023:Coronary Angiography / Q000009:adverse effects* / Q000379:methods*; D003326:Coronary Circulation / Q000502:physiology; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology / Q000517:prevention & control; D015227:Lipid Peroxidation / Q000502:physiology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000503:physiopathology*; D014292:Trimetazidine / Q000008:administration & dosage / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D000975:Antioxidants; D014665:Vasodilator Agents; D014292:Trimetazidine