Synthesis and properties of 2-(4-substituted)butyl derivatives of some 2,3-dihydro-1,3-dioxo-1H-pyrrolo[3,4-c]pyridines.
The synthesis of 2-(4-substituted)butyl derivatives of 4-alkoxy-2,3-dihydro-6-methyl-1,3-dioxo-1H-pyrrolo[3,4-c]pyridine (10-15) and the results of preliminary pharmacological screening are described in this paper. All the compounds tested showed a strong analgesic action, suppressed spontaneous locomotor activity and prolonged barbiturate sleep. Except 10, all significantly decreased systolic and diastolic blood pressure.
Sladowska
H
H
Department of Chemistry of Drugs, Wrocław University of Medicine, Kraków, Poland.
Szkatuła
D
D
Filipek
B
B
Maciag
D
D
Sapa
J
J
Zygmunt
M
M
D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010147:Pain Measurement / Q000187:drug effects; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D013055:Spectrophotometry, Infrared; D013874:Thiopental / Q000494:pharmacology
D018712:Analgesics, Non-Narcotic; D001463:Barbiturates; D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D011725:Pyridines; D011758:Pyrroles; D013874:Thiopental