[Radiolytic oxidation of tamoxifen with the free radicals OH- and/or HO2-].
Tamoxifen is the most widely used antiestrogen in the treatment of breast cancer. In this work, we have studied its antioxidant properties. We have investigated the ability of tamoxifen to scavenge, in vitro, *OH and (or) HO2* free radicals that are produced by water radiolysis. Aqueous solutions of tamoxifen of concentrations ranging between 10(-5) and 2.5 x 10(-5) M have been irradiated (gamma 137Cs) in aerated acidic medium (H3PO4 10(-3) M or HCOOH 10(-1) M). The results show that tamoxifen reacts quantitatively with *OH free radicals but does not react with HO2* free radicals under our experimental conditions.
Laboratoire de Chimie-Physique, UMR 8601, Centre national de la recherche scientifique, Université René Descartes, Paris, France. Leguene@biomedicale.univ-paris5.fr
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Leguéné
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Clavère
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Jore
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Gardès-Albert
D018931:Antineoplastic Agents, Hormonal / Q000737:chemistry*; D016166:Free Radical Scavengers / Q000737:chemistry*; D005720:Gamma Rays; D006861:Hydrogen Peroxide; D017665:Hydroxyl Radical; D010084:Oxidation-Reduction; D011675:Pulse Radiolysis; D013629:Tamoxifen / Q000737:chemistry*; D014867:Water / Q000737:chemistry
D018931:Antineoplastic Agents, Hormonal; D016166:Free Radical Scavengers; D014867:Water; D013629:Tamoxifen; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide