The preterm prediction study: maternal serum relaxin, sonographic cervical length, and spontaneous preterm birth in twins.
OBJECTIVE
The risk of spontaneous preterm birth has been related to decreased cervical length and to increased serum relaxin. To explore a relationship between these findings, we used data collected from two prior studies to correlate relaxin levels with cervical length and risk of spontaneous preterm birth in women with twin pregnancies.


METHODS
In a secondary analysis of data collected in two previous observational studies of risk factors for preterm birth, relaxin levels in maternal serum and cervical length were measured at 24 (n= 188) and 28 (n= 145) weeks in women with spontaneous twin pregnancies. Relaxin, as a continuous variable, was related by logistic regression analysis to risk of spontaneous preterm birth before 37, 35, and 32 weeks' gestation, and by Spearman correlation coefficients to cervical length at 24 and 28 weeks. Cervical length at 24 weeks was known to be correlated with spontaneous preterm birth before 37, 35, and 32 weeks (P =.03,.01, and.002, respectively) in this study population.


RESULTS
Cervical length did not correlate with relaxin levels at 24 (P=.601) or 28 (P=.304) weeks. Relationships between relaxin and spontaneous preterm birth were observed at 24 weeks for births before 37 weeks (odds ratio [OR] 1.56, 95% confidence interval [CI] 1.00, 2.44; P=.05), and at 28 weeks for births before 35 weeks (OR 1.97, 95% CI 1.05, 3.70; P=.034) and 32 weeks (OR 2.43, 95% CI 1.01, 5.83; P=.048).


CONCLUSIONS
The absence of an association between relaxin and cervical length suggests that increased relaxin does not explain the inverse correlation between cervical length and spontaneous preterm birth in women with spontaneous twin pregnancies.
The National Institute of Child Health and Human Development Maternal Fetal Medicine Network, Bethesda, Maryland, USA.
J D
JD
Iams
L T
LT
Goldsmith
G
G
Weiss
D000328:Adult; D002584:Cervix Uteri / Q000033:anatomy & histology*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood; D005865:Gestational Age; D006801:Humans; D016015:Logistic Models; D007752:Obstetric Labor, Premature / Q000175:diagnosis*; D016017:Odds Ratio; D011247:Pregnancy; D011272:Pregnancy, Multiple; D044469:Racial Groups; D012065:Relaxin / Q000097:blood*; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012907:Smoking / Q000097:blood; D014427:Twins
D012065:Relaxin