Nanoscale fluorescent sensors for intracellular analysis.
There is a growing interest in the development of submicron optochemical sensing devices. Miniaturization of sensors to nano-dimensions decreases their typical response time down to the millisecond time scale. Their penetration volume is reduced to a few cubic micrometers and they exhibit a spatial resolution at the nanometer scale. In this review the fabrication of submicron optical fiber fluorescent sensors and particle-based fluorescent nanosensors is described. The functional characteristics of these exciting miniaturized fluorescent sensors and their applications for quantitative measurement of intracellular analytes are demonstrated.
University of New Orleans, Department of Chemistry, LA 70148, USA.
J
J
Lu
Z
Z
Rosenzweig
D000818:Animals; D015374:Biosensing Techniques; D005336:Fiber Optic Technology; D005456:Fluorescent Dyes / Q000737:chemistry*; D008264:Macrophages / Q000378:metabolism; D008904:Miniaturization; D055100:Optical Fibers; D010100:Oxygen / Q000032:analysis; D013194:Staining and Labeling / Q000379:methods*
D005456:Fluorescent Dyes; D010100:Oxygen