Association of white blood cell count with increased mortality in acute myocardial infarction and unstable angina pectoris. OPUS-TIMI 16 Investigators.
We observed in a study of 7,651 patients with acute coronary syndromes that a white blood cell (WBC) count of > 10,000 was associated with increased 30-day and 10-month mortality (6.2% vs 3.2% to 3.6% for WBC count < 10,000; p < 0.000). With its simplicity and widespread availability, WBC count could serve as a simple, inexpensive, new tool for risk stratification in acute coronary syndromes.
Cannon
C P
CP
Cardiovascular Division, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. cannon@partners.org
McCabe
C H
CH
Wilcox
R G
RG
Bentley
J H
JH
Braunwald
E
E
D000368:Aged; D000409:Alanine / Q000008:administration & dosage; D000789:Angina, Unstable / Q000188:drug therapy / Q000276:immunology / Q000401:mortality*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000276:immunology / Q000401:mortality*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage; D011759:Pyrrolidines / Q000008:administration & dosage; D012307:Risk Factors; D015996:Survival Rate
D010975:Platelet Aggregation Inhibitors; D011759:Pyrrolidines; C120234:orbofiban; D000409:Alanine