Intracardiac echocardiographic evaluation of ventricular mural swelling from radiofrequency ablation in chronic myocardial infarction: irrigated-tip versus standard catheter.
BACKGROUND
The production of larger, particularly deeper lesions may improve the success rate for radiofrequency (RF) ablation of post infarction ventricular tachycardia (VT). Therapeutic RF ablation causes left ventricular (LV) mural swelling. This swelling can be detected as increased wall thickness at the ablation site by intracardiac echocardiography (ICE) and correlates with pathologic lesion size. This study compared the extent of mural swelling caused by linear ablation lesions created with irrigated tip and standard RF ablation in a porcine model of healed anterior infarction.


RESULTS
In anesthetized closed-chest swine ICE guided multiple RF applications to construct linear lesions at the border zone of the infarct region using an irrigated RF (n=6 swine) and a standard RF (n=6 swine) ablation catheter. 47 individual lesions were created with irrigated RF ablation; 57 lesions created with standard RF ablation. At all sites, wall thickness (measured at end-diastole Pre- and 1 min Post-RF delivery) increased following either irrigated (p<0.0001) or standard (p<0.004) RF deployment. Irrigated RF ablation produced more mural swelling at border zone sites than standard RF ablation (wall thickness increase of 21.2 versus 15.1 %, p<0.003). This difference was more pronounced at RF sites within the infarct (40.7 versus 12.0 %, p<0.0007). Thrombus formation or intramural explosion were not observed; surface crater formation was not more frequent with irrigated compared to standard RF ablation (14/47 versus 12/57 lesions, p=NS).


CONCLUSIONS
Irrigated RF ablation may produce larger lesions than standard RF ablation, particularly for ablation targets within infarcted tissue. ICE imaging provides on line data about the characteristics of the developing lesion which may prove useful in dosing irrigated-tip RF energy application.
Ren
J F
JF
Division of Cardiovascular Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104-2692, USA. jfren@mail.med.upenn.edu
Callans
D J
DJ
Michele
J J
JJ
Dillon
S M
SM
Marchlinski
F E
FE
D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004566:Electrodes; D006352:Heart Ventricles / Q000000981:diagnostic imaging* / Q000473:pathology; D009203:Myocardial Infarction / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D017180:Tachycardia, Ventricular / Q000209:etiology / Q000601:surgery*; D007507:Therapeutic Irrigation; D018084:Ultrasonography, Interventional