Extra copies of chromosomes 7, 8, 12, 19, and 21 are recurrent in adamantinoma.
Adamantinoma of long bones is a rare neoplasm predominantly involving the tibia. Cytogenetic studies of adamantinoma are few. Cytogenetic or molecular cytogenetic analysis of four adamantinomas, and a review of eleven cases in the literature reveals extra copies of chromosomes 7, 8, 12, 19, and 21 as recurrent in this neoplasm. Adamantinoma may be confused with a variety of primary and metastatic epithelial and mesenchymal neoplasms. Observation of these aneuploidies may be useful in establishing the diagnosis of adamantinoma.
Kanamori
M
M
Departments of Pathology and Microbiology, Center for Human Molecular Genetics, University of Nebraska Medical Center, Omaha, Nebraska, USA.
Antonescu
C R
CR
Scott
M
M
Bridge
R S
RS
Neff
J R
JR
Spanier
S S
SS
Scarborough
M T
MT
Vergara
G
G
Rosenthal
H G
HG
Bridge
J A
JA
D000293:Adolescent; D000328:Adult; D000564:Ameloblastoma / Q000235:genetics* / Q000473:pathology; D000782:Aneuploidy; D002877:Chromosomes, Human; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000235:genetics* / Q000473:pathology; D005360:Fibula / Q000473:pathology; D006801:Humans; D007621:Karyotyping; D008297:Male; D012008:Recurrence; D013977:Tibia / Q000473:pathology*