The post-prandial state and macrovascular disease: relevance to diabetes mellitus.
There is increasing evidence that the post-prandial state is an important contributing factor to the development of atherosclerosis. In non-diabetic subjects the atherosclerotic risk factors comprised in the categories of lipids, coagulation system and endothelial function may be adversely modified in the post-prandial phase. The generation of an oxidative stress may be the common pathway through which eating may induce these alterations. In diabetic patients these phenomena may be amplified by post-prandial hyperglycemia. There is a growing thought that diabetes is a cardiovascular disease.
Shah
S N
SN
All India Institute of Diabetes & Consultant, SL Raheja, Sir HN Hospital & Bhatia General Hospital, Mumbai.
Joshi
S R
SR
D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000503:physiopathology; D003925:Diabetic Angiopathies / Q000209:etiology* / Q000503:physiopathology; D004730:Endothelium, Vascular / Q000502:physiology; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D006943:Hyperglycemia / Q000150:complications* / Q000503:physiopathology; D018384:Oxidative Stress / Q000502:physiology; D019518:Postprandial Period / Q000502:physiology; D012307:Risk Factors; D014652:Vascular Diseases / Q000209:etiology*
D006442:Glycated Hemoglobin