DNA vaccines against tuberculosis.
Application of the DNA vaccine approach to tuberculosis in laboratory animals is helping to clarify the immunological mechanisms underlying protective immunity. Unexpectedly, it has also indicated clear potential for clinical application. This review looks at the implication of recent advances for the development of practical TB vaccines.
National Institute for Medical Research, Ridgeway, Mill Hill, London, NW7 1AA, UK. dlowrie@nimr.mrc.ac.uk
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Lowrie
D000942:Antigens, Bacterial / Q000235:genetics; D001500:BCG Vaccine / Q000235:genetics / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D007167:Immunotherapy; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology / Q000517:prevention & control* / Q000628:therapy; D019444:Vaccines, DNA / Q000235:genetics / Q000494:pharmacology* / Q000627:therapeutic use
D000942:Antigens, Bacterial; D001500:BCG Vaccine; D019444:Vaccines, DNA