Mitochondria, aging and longevity--a new perspective.
A new perspective is emerging indicating that mitochondria play a critical role in aging not only because they are the major source and the most proximal target of reactive oxygen species, but also because they regulate stress response and apoptosis. Recent literature indicates that, in response to stress, a variety of molecules translocate to and localise in mitochondria. These molecules are likely to interact with each other, in order to mediate mitochondria/nucleus cross-talk and to regulate apoptosis. We surmise that an integration of signals in multimolecular complexes occurs at mitochondrial level. These phenomena can be of critical importance for human aging and longevity.
Department of Experimental Pathology, University of Bologna, Italy. ssalvio@alma.unibo.it
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S
Salvioli
M
M
Bonafè
M
M
Capri
D
D
Monti
C
C
Franceschi
D000375:Aging / Q000378:metabolism*; D017209:Apoptosis; D006801:Humans; D008136:Longevity / Q000502:physiology*; D008928:Mitochondria / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism
D017382:Reactive Oxygen Species