The roles of dopamine oxidative stress and dopamine receptor signaling in aging and age-related neurodegeneration.
Aging is accompanied by a decline of functions controlled by the central dopaminergic system, such as reduced locomotor activity, motivation, impairment of memory formation, and learning deficits. The molecular mechanisms underlying age-related impairment of dopaminergic functions are unknown. Current literature and our own recent work, which are reviewed and summarized in the present paper, suggest that dopamine oxidative stress and its subsequent signaling may contribute to the aging of dopaminergic system.
Luo
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Gerontology Research Center, NIA/NIH, Baltimore, MD 21224, USA. luoyq@helix.nih.gov
Roth
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GS
D000375:Aging; D000818:Animals; D017209:Apoptosis; D001253:Astrocytes / Q000378:metabolism; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D009457:Neuroglia / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D017382:Reactive Oxygen Species; D011954:Receptors, Dopamine / Q000502:physiology*; D015398:Signal Transduction
D017382:Reactive Oxygen Species; D011954:Receptors, Dopamine; D004298:Dopamine