[Effects of chronic stress on the learning and memory ability and hippocampal LTP in rats].
OBJECTIVE
A chronic stress model in 21 days with multi-stressors was applied to question the effects of stress on the learning and memory ability and the hippocampal neuronal synaptic plasticity in rats, using the Y maze test and LTP electrophysiological recording in vivo.


RESULTS
The impairment of spatial learning and memory ability and an obvious suppression in LTP in hippocampal dentate gyrus was observed in stress group after chronic stress.


CONCLUSIONS
The hippocampal synaptic plasticity may be decreased by the chronic stress. And then, the learning and memory ability may also be impaired consequently.
Institute of Health and Environmental Medicine, Tianjin 300050.
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Q
Ma
J
J
Wang
Z H
ZH
Yang
H T
HT
Liv
F H
FH
Chao
D000818:Animals; D004558:Electric Stimulation / Q000009:adverse effects; D006624:Hippocampus / Q000503:physiopathology*; D007858:Learning / Q000502:physiology*; D017774:Long-Term Potentiation; D008297:Male; D008568:Memory / Q000502:physiology; D009622:Noise / Q000009:adverse effects; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology*