Partial caudal duplication in a newborn associated with meningomyelocele and complex heart anomaly.
BACKGROUND
Caudal duplication is a spectrum of rare congenital anomalies with a possible heterogeneous pathogenesis including incomplete separation of monovular twins.


METHODS
We report an autopsy case of a full-term infant with incomplete caudal duplication syndrome associated with multiple anomalies.


RESULTS
These anomalies included a duplicated penis; double urinary bladder with an attenuated tunica muscularis; duplication of lower bowel with two ilia, appendices and colons; colonic hypogangliosis and left imperforated anus associated with rectourethral fistula. Other anomalies consisted of sacral meningomyelocele, sacral duplication with hypoplastic left sacrum and pelvic bones, muscle atrophy and hypoplasia of the left lower extremity, abnormal lobation of liver with stomach entrapment, omphalocele, and right atrial isomerism syndrome. The complex pattern of anomalies suggests the possibility that partial caudal duplication might be part of the spectrum of conjoined twinning.
Department of Pathology, University of California, San Diego Medical Center, San Diego, California 92103-8321, USA.
S I
SI
Bannykh
G I
GI
Bannykh
F L
FL
Mannino
K L
KL
Jones
L
L
Hansen
K
K
Benirschke
E
E
Masliah
D000015:Abnormalities, Multiple; D001921:Brain / Q000002:abnormalities; D004065:Digestive System Abnormalities; D006330:Heart Defects, Congenital / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008591:Meningomyelocele / Q000473:pathology*; D013116:Spinal Cord / Q000002:abnormalities*; D014564:Urogenital Abnormalities / Q000473:pathology