Partial characterization and tissue distribution of the feline mu opiate receptor.
Heroin abuse is a common route of acquiring HIV-1 infection. However, the effects of opiates on lentivirus disease progression are not well understood. Feline immunodeficiency virus is recognized as a good animal model for HIV-1, but characterization of the opiate receptor system in cats is lacking. Here we report the partial sequencing of the feline mu opiate receptor (MOR) and demonstrate a homology of 92 and 93% to the published human MOR sequences. Additionally, MOR transcripts were detected in the feline brain and tonsil but not in the spleen. Also, specific receptor ligand interactions were observed using microphysiometry.
Billet
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Immune Complex Corporation, San Diego, CA 92121, USA.
Billaud
J N
JN
Phillips
T R
TR
D000818:Animals; D001483:Base Sequence; D002415:Cats; D018076:DNA, Complementary / Q000378:metabolism; D004195:Disease Models, Animal; D015536:Down-Regulation / Q000187:drug effects; D016181:Feline Acquired Immunodeficiency Syndrome / Q000378:metabolism*; D015658:HIV Infections / Q000378:metabolism*; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects / Q000378:metabolism*; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D009020:Morphine / Q000494:pharmacology*; D009294:Narcotics / Q000494:pharmacology*; D017450:Receptors, Opioid, mu / Q000378:metabolism*
D018076:DNA, Complementary; D009294:Narcotics; D017450:Receptors, Opioid, mu; D009020:Morphine