Hypernatremia in a non insulin dependent (type 2) diabetic patient with central diabetes insipidus.
We describe a patient with central diabetes insipidus who presented with hyperosmolar, non-ketotic hyperglycaemia. The role in this case of reduced thirst sensation with decreased water intake and abnormal AVP production illustrates the importance of these protective mechanisms in normal physiology regarding maintenance of normal plasma osmolality. Despite the complex pathophysiology in this patient, fluid resuscitation aimed at normalisation of the water deficit resulted in full recovery.
Department of General Internal Medicine, LUMC, C1-R, P.O. Box 9600, 2300 RC, Leiden, The Netherlands.
J
J
Kavelaars
J T
JT
Tamsma
A E
AE
Meinders
D001932:Brain Neoplasms / Q000150:complications; D003919:Diabetes Insipidus / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D005440:Fluid Therapy; D006801:Humans; D006955:Hypernatremia / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000150:complications; D008297:Male; D008875:Middle Aged