[Relations between ankylosing spondyloarthritis and HLA-B27 in various ethnic groups in Russia].
OBJECTIVE
To characterize relationship between prevalence of ankylosing spondylarthritis (ASA) and incidence rate of HLA-B27 in genotypically different ethnic groups of Russia with interpolation of the results to other populations.


METHODS
2287 individuals from genotypically different ethnic groups were examined in overall one-stage epidemiological trial.


RESULTS
Prevalence of ASA in ethnic groups ranged from 0.2 to 2.0% while occurrence of HLA0B27--from 15 to 40%. Rate of correlation between the disease prevalence and incidence of B27 was 0.82. The equation for calculation of ASA incidence rate by HLA-B27 incidence was devised: AC(%) = -0.40 + 0.06x.


CONCLUSIONS
In most world populations prevalence of ASA correlates with population frequency HLA-B27 though in some ethnic groups this correlation is absent. Consequently, ASA is genetically heterogenous.
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D000293:Adolescent; D000328:Adult; D044466:Asian People / Q000235:genetics; D005387:Finland / Q000208:ethnology; D005838:Genotype; D015796:HLA-B27 Antigen / Q000097:blood*; D006801:Humans; D015995:Prevalence; D012426:Russia / Q000453:epidemiology; D013167:Spondylitis, Ankylosing / Q000208:ethnology* / Q000235:genetics / Q000276:immunology; D044465:White People / Q000235:genetics
D015796:HLA-B27 Antigen