[Long-term effects of irradiation in the progeny of mammalian cells].
It is shown that gamma-irradiation has remote consequences for mammalian cells cultivated in vitro. Many generations in the progeny of cells surviving acute and chronic irradiation at high and low doses are characterized by a number of abnormalities, including delayed cell death, the formation of micronuclei and giant cells, an increased frequency of sister chromatid exchanges, a reduced potential for repair, the loss of adaptive response, and increased radiosensitivity. These phenomena are regarded as manifestations of genomic instability induced by ionizing radiation.
Pelevina
I I
II
Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977 Russia.
Gotlib
V Ia
VIa
Kudriashova
O V
OV
Antoshchina
M M
MM
D000818:Animals; D016923:Cell Death / Q000528:radiation effects*; D002467:Cell Nucleus / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts; D005720:Gamma Rays; D006367:HeLa Cells; D006801:Humans; D015162:Micronucleus Tests; D011836:Radiation Tolerance; D013997:Time Factors