[Levels of cystatin C, activity of antipapain and antitrypsin in plasma of patients with diabetes mellitus type 2].
In plasma of 72 patients with diabetes mellitus type 2, cystatin C concentration, the antipapain as well as antitrypsin activities were determined. Statistically significant increase of levels of all the examined parameters (higher for inhibitors of cysteine proteases) was found in comparison to healthy persons. When considering types of vascular complications, the highest concentration of cystatin C and the strongest positive correlation with antipapain activity was found in the group of patients with microangiopathy. It might be connected with glomerular damages. Only antipapain as well as antitrypsin activities showed significant correlation with glycaemic control as measurement by glycated haemoglobin concentration.
Katedry i Kliniki Angiologii Akademii Medycznej we Wrocławiu.
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D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood; D003928:Diabetic Nephropathies / Q000378:metabolism; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010206:Papain / Q000378:metabolism*; D000515:alpha 1-Antitrypsin / Q000032:analysis*
D055316:Cystatin C; D015891:Cystatins; D006442:Glycated Hemoglobin; D010206:Papain; D000515:alpha 1-Antitrypsin; C525030:CST3 protein, human