Chemokine receptor desensitization in tumor-bearing mice.
We found that the murine breast cancer cell line 4T1 constitutively produced several chemokines capable of recruiting T cells. Additionally, supernatants from the tumor cell line mediated chemotaxis of T cells in a pertussis toxin-sensitive manner, indicating that these chemokines were functional. However, we also found an impaired chemotactic ability of splenic T cells in mice bearing these same tumors. The receptors for RANTES, MCP-1, and SLC were desensitized. Thus, the impaired chemotactic ability of T cells in tumor-bearing mice may explain why tumors that secrete chemokines grow progressively in a host.
Kurt
R A
RA
Laboratory of Cellular Immunology, Oregon Cancer Center, Portland, Oregon 97213, USA. kurtr@lafayette.edu
Baher
A
A
Wisner
K P
KP
Tackitt
S
S
Urba
W J
WJ
D000818:Animals; D002634:Chemotaxis, Leukocyte; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000276:immunology*; D019707:Receptors, Chemokine / Q000032:analysis / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology
D019707:Receptors, Chemokine