Health information in material safety data sheets for a chemical which causes asthma.
OBJECTIVE
To assess the quality of health information on material safety data sheets (MSDS) for a workplace chemical that is well known to cause or exacerbate asthma (toluene diisocyanate, TDI).


METHODS
We reviewed a random sample of 61 MSDSs for TDI products produced by 30 manufacturers.


RESULTS
Two physicians independently abstracted data from each MSDS onto a standardized audit form. One manufacturer provided no language about any respiratory effects of TDI exposure. Asthma was listed as a potential health effect by only 15 of the 30 manufacturers (50%). Listing asthma in the MSDS was associated with higher toluene diisocyanate concentrations in the product (P <.042). Allergic or sensitizing respiratory reactions were listed by 21 manufacturers (70%).


CONCLUSIONS
Many MSDSs for toluene diisocyanate do not communicate clearly that exposure can cause or exacerbate asthma. This suggests that physicians should not rely on the MSDS for information about health effects of this chemical.
Department of Preventive Medicine, and Department of Internal Medicine, University of Kansas School of Medicine-Wichita, Wichita, KS, USA. lfrazier@kumc.edu
L M
LM
Frazier
B W
BW
Beasley
G K
GK
Sharma
A A
AA
Mohyuddin
D001249:Asthma / Q000139:chemically induced*; D004348:Drug Labeling / Q000592:standards*; D006801:Humans; D009784:Occupational Diseases / Q000139:chemically induced*; D016273:Occupational Exposure / Q000009:adverse effects*; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*
D014051:Toluene 2,4-Diisocyanate