Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice.
The acute and accumulated toxicity of the rare earth borotungstate heteropoly blues, HPB-2, Ce2H3[BW9(VI)W2(V)Mn(H2O)O39].12H2O, which is active against influenza virus in Kunming mice, were investigated in Kunming mice following oral and intraperitoneal administration. The activity of HPB-2 against influenza virus (FM1) in the mice was then investigated. HPB-2, given either orally (p.o.) or intraperitoneally (i.p.), was shown to have activity. HPB-2 was shown to be more effective than the positive control, ribavirin, and it was also found that i.p. administration was more effective than p.o. administration.
State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry, Zhongshan University, Guangzhou, PR China. cesliuj@zsu.edu.cn
J
J
Liu
W
W
Mei
Y
Y
Li
E
E
Wang
L
L
Ji
P
P
Tao
D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D001896:Boron Compounds / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy*; D017973:Tungsten Compounds / Q000008:administration & dosage*
D000998:Antiviral Agents; D001896:Boron Compounds; D017973:Tungsten Compounds; C067364:borotungstic acid