Filamins as integrators of cell mechanics and signalling.
Filamins are large actin-binding proteins that stabilize delicate three-dimensional actin webs and link them to cellular membranes. They integrate cellular architectural and signalling functions and are essential for fetal development and cell locomotion. Here, we describe the history, structure and function of this group of proteins.
Stossel
T P
TP
Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. tstossel@rics.bwh.harvard.edu
Condeelis
J
J
Cooley
L
L
Hartwig
J H
JH
Noegel
A
A
Schleicher
M
M
Shapiro
S S
SS
D002462:Cell Membrane / Q000502:physiology; D003285:Contractile Proteins / Q000502:physiology*; D064448:Filamins; D008840:Microfilament Proteins / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D003285:Contractile Proteins; D064448:Filamins; D008840:Microfilament Proteins