Triplex-forming molecules for modulation of DNA information processing.
The design of specific DNA ligands is an important challenge in biological and biomedical sciences. Targeting the source of genetic information may allow highly efficient gene-directed modulation of cell function. Triplex-forming molecules specifically recognize oligopyrimidine/oligopurine sequences by hydrogen bonding interactions. In cell cultures they have been used successfully to downregulate or upregulate transcription in a gene-specific manner or to induce site-directed mutagenesis and recombination. For biotechnological applications, triplex-forming molecules are powerful tools for gene-specific chemistry.
Laboratoire de Biophysique Muséum National d'Histoire Naturelle, CNRS UMR 8646-INSERM U.201, 43 rue Cuvier-75231 Paris, France. giovanna@mnhn.fr
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Giovannangeli
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Hélène
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D004249:DNA Damage; D006801:Humans; D008024:Ligands; D016297:Mutagenesis, Site-Directed; D009690:Nucleic Acid Conformation / Q000187:drug effects; D009841:Oligonucleotides / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D020135:Peptide Nucleic Acids / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011995:Recombination, Genetic / Q000187:drug effects; D014158:Transcription, Genetic / Q000187:drug effects; D015533:Transcriptional Activation / Q000187:drug effects
D008024:Ligands; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D004247:DNA