Sensitivity of Borrelia burgdorferi strains isolated in the Czech Republic.
We tested in vitro susceptibility of 5 strains of Borrelia burgdorferi sensu lato, isolated from patients in the Czech Republic, to penicillin G, ceftriaxone, cefotaxime, doxycycline and amoxycillin combined with clavulanic acid by broth macrodilution method on BSK medium. Results confirmed high efficacy of the tested drugs, particularly on B. afzelii and B. burgdorferi sensu stricto. A strain of B. garinii, isolated from cerebrospinal fluid, required a longer period of antibiotic activity before inhibitory effects were achieved. Penicillin G was effective only in higher concentrations, attainable by i. v. application. Ceftriaxone had the strongest borreliacidal activity.
Centre of Preventive Medicine, Department of Epidemiology, 3rd Medical Faculty, Charles University, Prague, Czech Republic.
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D
Janovská
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Hulínská
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Godová
D000658:Amoxicillin / Q000494:pharmacology / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000494:pharmacology* / Q000627:therapeutic use; D015748:Borrelia burgdorferi Group / Q000187:drug effects* / Q000302:isolation & purification; D002439:Cefotaxime / Q000494:pharmacology / Q000627:therapeutic use; D002443:Ceftriaxone / Q000494:pharmacology / Q000627:therapeutic use; D019818:Clavulanic Acid / Q000494:pharmacology / Q000627:therapeutic use; D018153:Czech Republic; D004318:Doxycycline / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D066298:In Vitro Techniques; D008193:Lyme Disease / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000494:pharmacology / Q000627:therapeutic use; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D019818:Clavulanic Acid; D002443:Ceftriaxone; D000658:Amoxicillin; D004318:Doxycycline; D002439:Cefotaxime; D010400:Penicillin G