Modified synthesis and antiangiogenic activity of linomide.
A modified procedure for the synthesis of Linomide is described. The synthesized drug was characterized and assessed for its in vivo antiangiogenic activity. In a murine angiogenesis assay Linomide treatment inhibited new blood vessel formation as documented by reduced microvessel area and blood volume.
Khan
S R
SR
Johns Hopkins Oncology Center, Baltimore, MD 21205, USA. khansa@jhmi.edu
Mhaka
A
A
Pili
R
R
Isaacs
J T
JT
D020533:Angiogenesis Inhibitors / Q000138:chemical synthesis*; D000818:Animals; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice
D020533:Angiogenesis Inhibitors; D006912:Hydroxyquinolines; C045282:roquinimex