[Effects of bioflavonoids on the toxicity of T-toxin in rats. A morphological study].
Subacute toxicity of T-2 toxin in rats was characterized by a primary defeat of liver, thymus, spleen and intraorgan arteries. In 75% of animals found out increase of the size and adipose infiltration of a liver, in all animals--reduction of the size of thymus (sharp) and spleen (moderate) and pronounced hypoplasia of lymphoid tissue. In the majority of rats vacuolation of cytoplasma of smooth-muscular walls of coronary and intrarenal arteries was revealed. In animals received T-2 toxin against a background of a diet with addition a flour from seeds of milk thistle with high contents of flavonoids, described morphological changes were expressed to a lesser degree and were observed less often. Moderate periportal adipose infiltration of a liver was revealed in 30% of animals, occupancy by cells of lymphoid tissue increased, the quantity and sizes of vacuoles in walls of vessels decreased.
A L
AL
Pozdniakov
L V
LV
Kravchenko
L I
LI
Avren'eva
N B
NB
Kazenkina
D000818:Animals; D003331:Coronary Vessels / Q000187:drug effects* / Q000473:pathology; D003593:Cytoplasm / Q000187:drug effects; D004032:Diet; D005419:Flavonoids / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000473:pathology; D051381:Rats; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D013605:T-2 Toxin / Q000037:antagonists & inhibitors* / Q000633:toxicity*; D013950:Thymus Gland / Q000187:drug effects* / Q000473:pathology
D005419:Flavonoids; D013605:T-2 Toxin