[Application of IHW2 purged bone marrow to autologous bone marrow transplantation in the treatment of acute myeloid leukemia].
OBJECTIVE
To observe the clinical effectiveness of IHW2 purged autologous bone marrow transplantation (ABMT) in the treatment of AML patients.


METHODS
Large volume of bone marrow was purged in vitro by IHW2 and then reinfused to patients for ABMT.


RESULTS
All of the three patients transplanted with IHW2 purged autologous bone marrow successfully reconstituted hemopoiesis. Two patients got continuous complete remission for 36+ and 34+ months, respectively. The karyotype of one of the two patient was 46,XY,del(16)(q22) before ABMT and changed to 46,XY in 2 months after transplantation. The third patient relapsed after ABMT 19 months.


CONCLUSIONS
The preliminary study suggests that IHW2 may have certain purging effect on leukemic cells and is safe for clinical application.
Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.
R
R
Jiang
M
M
Han
Y
Y
Zhao
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D016465:Bone Marrow Purging / Q000379:methods; D016026:Bone Marrow Transplantation; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D008297:Male; D009025:Morpholines / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009025:Morpholines; C052796:N-dodecylmorpholine