A novel derivative pentacyclic triterpene and omega 3 fatty acid.
Adjuvant induced arthritis (AIA) is accompanied by marked changes in the levels of lysosomal enzymes, glycoproteins and metabolic turnover of collagen. The role of a pentacyclic triterpene and eicosapentaenoic acid (EPA) derivative--Lupeol-EPA (50 mg/kg body weight--orally) was tested in vivo in rats. The increased activities of lysosomal enzymes and glycoproteins associated with decreased collagen in arthritic animals were significantly altered to nearly that of controls. Indomethacin (3 mg/kg body weight) was used as a reference compound. The therapeutic usefulness of Lupeol-EPA derivative in inflammatory conditions is attractive and deserves further work in this direction.
Department of Medical Biochemistry, University of Madras, Taramani, Chennai, India.
R M
RM
Latha
M
M
Lenin
M
M
Rasool
P
P
Varalakshmi
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001168:Arthritis / Q000188:drug therapy*; D050260:Carbohydrate Metabolism; D003094:Collagen / Q000378:metabolism*; D004195:Disease Models, Animal; D015118:Eicosapentaenoic Acid / Q000494:pharmacology*; D005227:Fatty Acids / Q000627:therapeutic use*; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D008247:Lysosomes / Q000201:enzymology / Q000378:metabolism*; D053978:Pentacyclic Triterpenes; D051381:Rats; D017208:Rats, Wistar; D014315:Triterpenes / Q000627:therapeutic use*; D000094042:Lupanes
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003094:Collagen; D015118:Eicosapentaenoic Acid; D005227:Fatty Acids; D006023:Glycoproteins; D007213:Indomethacin; D053978:Pentacyclic Triterpenes; D014315:Triterpenes; C010480:lupeol; D000094042:Lupanes