[Immunotropic and immunogenic properties of Burkholderia pseudomallei surface and membrane antigens].
The immunotropic and immunogenic properties of some chromatographic fractions of B. pseudomallei surface antigenic complex, as well as the preparations of B. pseudomallei outer and cytoplasmic membranes, were studied. The difference between the biopolymers under study in cytotoxicity, humoral and cell-mediated immunity characteristics, phagocytic activity were established. Some antigenic fractions (B, C, C1, H) showed perceptible protective activity (25-60%) in experiments on mice infected with B. pseudomallei virulent strain. One of the preparations of cytoplasmic membrane (CM-1) was also found to have protective properties (30%). Complex immunization with the antigenic complexes under study, introduced in combination with the immunomodulating agent Bromantan, was shown to enhance the protective effect.
Piven'
N N
NN
Research Institute for Plague Control, Volgograd, Russia.
Rybkin
V S
VS
Plekhanova
N G
NG
Zhukova
S I
SI
Viktorov
D V
DV
Avrorova
I V
IV
Demediuk
E A
EA
Drefs
N M
NM
Popov
S F
SF
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D016957:Burkholderia pseudomallei / Q000276:immunology* / Q000472:pathogenicity; D051379:Mice
D000942:Antigens, Bacterial; D000954:Antigens, Surface