Opioid poorly-responsive cancer pain. Part 2: basic mechanisms that could shift dose response for analgesia.
Basic research in experimental pain models may illuminate the phenomenon of cancer pain that is poorly responsive to opioid drugs. Research findings can be valuable in formulating new strategies in clinical practice. This review evaluated experimental observations in terms of the events that occur in cancer patients receiving opioid therapy for pain.
Anesthesia and Intensive Care Unit & Pain Relief and Palliative Care Unit, La Maddalena Cancer Center, Palermo, Italy.
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Mercadante
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Portenoy
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000627:therapeutic use*; D004351:Drug Resistance; D004361:Drug Tolerance; D006801:Humans; D009369:Neoplasms / Q000628:therapy*; D010166:Palliative Care / Q000379:methods*
D000701:Analgesics, Opioid