[Evolutionarily-conserved gene CKAP2,located in region 13q14.3 of the human genome, is frequently rearranged in various tumors].
The human CKAP2 gene, which is involved in diffuse large B-cell lymphomas, was localized via screening the GeneBridge 4 somatic cell radiation hybrid panel by means of the polymerase chain reaction (PCR). The CKAP2 gene was mapped between the WI-15460 and WI-3673 markers at the boundary between regions 13q14.3 and 13q21.1, at the distance of 14.39 cR (with 4.8 cR per cM) from the WI-5867 framework marker (lod score > 2.26). The human CKAP2 gene displayed high homology to mouse and rat expressed orthologs, A CKAP2-like sequence was found in human chromosome 14 and assumed to be a pseudogene resulting from duplication and subsequent mutations of the CKAP2 gene on chromosome 13. A possible role of the CKAP2 gene in oncogenesis associated with deletions and rearrangements of region 13q14.3-21.1 is discussed.
Udina
I G
IG
Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow, 117809 Russia. udina@vigg.ru
Baranova
A V
AV
Kompaniĭtsev
A A
AA
Sulimova
G E
GE
D000818:Animals; D002874:Chromosome Mapping; D002882:Chromosomes, Human, Pair 13; D017124:Conserved Sequence; D003598:Cytoskeletal Proteins / Q000235:genetics*; D019143:Evolution, Molecular; D015894:Genome, Human; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000235:genetics*; D016133:Polymerase Chain Reaction; D051381:Rats
C114988:CKAP2 protein, human; D003598:Cytoskeletal Proteins