Structural revision of four spiramine diterpenoid alkaloids from the roots of Spiraea japonica.
On the basis of detailed 1H-NMR 13C-NMR spectral analysis, especially by 2D NMR experiments (1H-1H COSY, HMQC, HMBC, and NOESY) as well as by chemical transformations. four isoatisine type diterpenoid alkaloids, spiramines P and Q, and U and T, have been reassigned as the 6beta hydroxyl and 6beta acetoxyl substituents, respectively, rather than the previously assigned 15alpha counterparts in our further studies on chemical constituents of the roots of Spiraea japonica var. acuta.
Wang
B G
BG
Laboratory of Phytochemistry, Kunming Institue of Botany, Chinese Academy of Sciences, Kunming.
Hong
X
X
Zuo
G Y
GY
Hao
X J
XJ
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification; D006576:Heterocyclic Compounds, 4 or More Rings / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010936:Plant Extracts / Q000032:analysis; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D000470:Alkaloids; D004224:Diterpenes; D006576:Heterocyclic Compounds, 4 or More Rings; D010936:Plant Extracts