DNA-based immunization against Lyssaviruses.
Rabies is a fatal encephalomyelitis. Most cases occur in developing countries and are transmitted by dogs. Because of their high cost, cell culture vaccines have not totally replaced the unsafe brain-derived vaccines which are still used in many developing countries. Moreover, there will be a need for vaccines against rabies-related viruses against which classical vaccines are not always effective. DNA vaccines would, therefore, be a valuable alternative for the production of cheaper rabies vaccines against a larger spectrum of viruses. In this review we report published data on DNA-based immunization with sequences encoding rabies and rabies-related virus antigens.
Laboratoire des Lyssavirus, Institut Pasteur, Paris, France. pperrin@pasteur.fr
P
P
Perrin
Y
Y
Jacob
N
N
Tordo
D000818:Animals; D004285:Dogs; D007114:Immunization; D018114:Lyssavirus / Q000235:genetics* / Q000276:immunology; D051379:Mice; D018353:Rhabdoviridae Infections / Q000517:prevention & control*; D019444:Vaccines, DNA / Q000276:immunology; D014765:Viral Vaccines / Q000235:genetics / Q000276:immunology
D019444:Vaccines, DNA; D014765:Viral Vaccines