Development of a Visual Analogue Scale questionnaire for subjective assessment of salivary dysfunction.
OBJECTIVE
This study's objective was to develop a Visual Analogue Scale (VAS) xerostomia questionnaire and to evaluate the validity and reliability for the clinical diagnosis of salivary gland dysfunction.


METHODS
Thirty-six healthy adults participated in this double-blind, crossover study. Each subject received an antisialagogue (glycopyrrolate) or placebo. Unstimulated and stimulated parotid and submandibular saliva samples were collected 16 times over a period of 6 hours. An 8-item VAS xerostomia questionnaire was administered after each saliva collection.


RESULTS
The results demonstrated significant reliability for 7 of the 8 VAS items, whereas validity was significant for unstimulated submandibular saliva. Moving averages were calculated for VAS and salivary flow rate values, and significant correlations were observed between these factors, indicating that changes in VAS responses were predictive of changes in salivary flow.


CONCLUSIONS
These findings suggest that this VAS xerostomia questionnaire may be helpful in the diagnosis of salivary dysfunction and for detecting changes in salivary flow rate values over time.
Dental Public Health, University of Michigan School of Public Health, Ann Arbor, USA.
S
S
Pai
E M
EM
Ghezzi
J A
JA
Ship
D000328:Adult; D000368:Aged; D018592:Cross-Over Studies; D003945:Diagnosis, Oral / Q000379:methods*; D004311:Double-Blind Method; D005260:Female; D006024:Glycopyrrolate / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018727:Muscarinic Antagonists / Q000494:pharmacology; D015203:Reproducibility of Results; D012463:Saliva / Q000187:drug effects / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D018709:Statistics, Nonparametric; D011795:Surveys and Questionnaires; D014987:Xerostomia / Q000175:diagnosis*
D018727:Muscarinic Antagonists; D006024:Glycopyrrolate