Changes in soluble interleukin-2 receptor level in serum and Na+-K+-exchanging ATPase activity in semen of infertile men caused by antisperm antibody.
OBJECTIVE
To explore the possible mechanisms of male infertility caused by antisperm antibody (AsAb).


METHODS
The soluble interleukin-2 receptor (sIL-2R) level in serum was analyzed by ELISA and Na+-K+-exchanging ATPase activity in semen by phosphorus (Pi) assay.


RESULTS
The sIL-2R level in serum was significantly higher and the Na+K+-exchanging ATPase activity in semen significantly lower in AsAb positive infertile men when compared with the controls.


CONCLUSIONS
The AsAb titer varies with the sIL-2R level in serum. A decrease in Na+-K+-exchanging ATPase activity in semen may play a role in male infertility caused by AsAb.
Department of Physiology, Harbin Medical University, China. liql@ems.hrbmu.edu.cn
J
J
Ni
Q L
QL
Li
W
W
Zhang
J S
JS
Xie
S L
SL
Bian
D000328:Adult; D001323:Autoantibodies / Q000276:immunology*; D006801:Humans; D007248:Infertility, Male / Q000276:immunology* / Q000378:metabolism*; D008297:Male; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012661:Semen / Q000201:enzymology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013094:Spermatozoa / Q000201:enzymology* / Q000276:immunology*
D001323:Autoantibodies; D015375:Receptors, Interleukin-2; D000254:Sodium-Potassium-Exchanging ATPase