[Correction of NO-dependent cardiovascular disorders by adaptation to hypoxia].
Spontaneously hypertensive rats (SHR-SP) were adapted to intermittent hypobaric hypoxia in an altitude chamber for 40 days. The adaptation to hypoxia prevented an excessive endothelium-dependent relaxation and hypotension characteristic of myocardial infarction. The adaptation also attenuated the increase in blood pressure and prevented impairment of the endothelium-dependent relaxation in SHR-SP. The universal nature of the adaptation allows to use it for correcting many cardiovascular disorders related to diverse alterations of NO metabolism.
Mashina
S Iu
SIu
Institute of General Pathology and Pathophysiology, Russian Acad. Med. Sci., Baltiyskaya St., 8, Moscow 125315, Russia.
Smirin
B V
BV
Malyshev
I Iu
IIu
Liamina
N P
NP
Senchikhin
V N
VN
Pokidyshev
D A
DA
Manukhina
E B
EB
D000222:Adaptation, Physiological; D000531:Altitude; D000818:Animals; D001011:Aorta / Q000503:physiopathology; D001794:Blood Pressure; D004730:Endothelium, Vascular / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology / Q000517:prevention & control*; D066298:In Vitro Techniques; D008297:Male; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology; D009203:Myocardial Infarction / Q000503:physiopathology / Q000517:prevention & control*; D009569:Nitric Oxide; D010100:Oxygen / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar
D009569:Nitric Oxide; D010100:Oxygen