Synthesis and antihypertensive activity of certain Mannich Bases of 2-ethoxycarbonylindoles and 5H-pyridazin.
This manuscript reports the synthesis of two series of Mannich Bases 3-12 and 21-40 obtained respectively by the reaction of either 2-ethoxycarbonylindoles 1-2 or 5H-pyridazino [4,5b]inoles 17-20 as a substrate with formalin and the appropriate 2 degrees amines under the suitable Mannich conditions. Fourteen of the synthesized Mannich basese were screened as antihypetensive agents in normotensive anesthetized rats. The effect of compound 4 in normotensive anesthetized dogs was also studied.
El-Gendy
A A
AA
Organic Chemistry Department, Faculty of Pharmacy, Cairo University, Egypt. elgendy1@Yahoo.com
El-Banna
H A
HA
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D007211:Indoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008352:Mannich Bases / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000959:Antihypertensive Agents; D007211:Indoles; D008352:Mannich Bases