[Pharmacokinetics of kanamycin after subcutaneous and intravenous administration in dogs].
Six beagle dogs were treated with kanamycin subcutaneously or intravenously in a dosage of 5 mg/kg. The plasma kanamycin concentration was measured over 24 hours by high pressure liquid chromatography with UV detection after derivatization and solid phase extraction. After subcutaneous application, kanamycin was absorbed quickly, and maximum plasma levels of 18.9 micrograms/ml in average after ca. 1 hour were measured. With complete systemic availability, the minimal inhibitory concentration of 4 micrograms/ml was maintained for 4 hours. After subcutaneous administration, kanamycin was terminally eliminated with a mean half life period of 2 hours.
Klinik für kleine Haustiere und Institut für Pharmakologie, Toxikologie und Pharmazie der Tierärztlichen Hochschule Hannover.
A
A
Calvo Wieland
A M
AM
Ehinger
M
M
Kietzmann
I
I
Nolte
D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005260:Female; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007612:Kanamycin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008657:Metabolic Clearance Rate; D010052:Ovariectomy
D007612:Kanamycin