[Hormone therapy in climacteric. Different effects of estrogen and gestagen on the risk of breast and endometrial cancer].
Use of hormone replacement therapy alleviates menopausal symptoms effectively, prevents osteoporosis and may even reduce the risk of cardiovascular disease and dementia. However, little is known about the risk of breast cancer and endometrial cancer after long-term use of different estrogen-progestin combinations. A large epidemiological study in Sweden, in which combined estrogen-progestin treatment was predominantly used, is reported.
Institutionen för medicinsk epidemiologi, Karolinska institutet, Stockholm. Cecilia.Magnusson@mep.ki.se
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D000368:Aged; D001943:Breast Neoplasms / Q000139:chemically induced*; D016022:Case-Control Studies; D002979:Climacteric / Q000187:drug effects*; D016889:Endometrial Neoplasms / Q000139:chemically induced*; D004964:Estriol / Q000009:adverse effects*; D015914:Estrogen Replacement Therapy / Q000009:adverse effects*; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D045167:Progesterone Congeners / Q000009:adverse effects*; D012307:Risk Factors; D013548:Sweden
D045167:Progesterone Congeners; D004964:Estriol