The JaICA-genox oxidative stress profile--an overview on the profiling technique in the oxidative stress assessment and management.
It is widely accepted that oxidative stress (OS) is a major causative factor for many of the age-related dysfunctions and specific diseases. Since the oxidative stress state (OSS) of an individual depends on hereditary, dietary, and environmental factors, there is a large heterogeneity in the population that may be related to disease incidence and longevity. Hence there is a need to assess how well an individual is coping against OS. The Japan Institute for the Control of Aging (JaICA) and Genox have jointly developed a profiling technique to measure the "Oxidative Stress Profiles (JaICA-Genox OSP)" of individuals and laboratory test animals. The JaICA-Genox OSP consists of about 45 different assays measuring the levels of oxidative damage in lipids and nucleic acids, and the antioxidant defenses in the serum. In addition, several bio-markers for cardiovascular disease risk are also measured, and assays to measure specific age- and sex-related hormones in the serum and urine, and race elements in serum, urine, and drinking water are also undertaken. This overview discusses the designing of the JaICA-Genox OSP and its application in the testing of human subjects.
Ochi
H
H
Japan Institute for the Control of Aging (JaICA), Fukuroi, Shizuoka.
Cheng
R Z
RZ
Kantha
S S
SS
Takeuchi
M
M
Ramarathnam
N
N
D000375:Aging; D000818:Animals; D000830:Animals, Laboratory; D015415:Biomarkers; D002318:Cardiovascular Diseases / Q000453:epidemiology; D004194:Disease; D005609:Free Radicals; D006304:Health Status; D006728:Hormones / Q000097:blood; D006801:Humans; D018384:Oxidative Stress; D012307:Risk Factors
D015415:Biomarkers; D005609:Free Radicals; D006728:Hormones