ACE gene polymorphism and long-term renal graft function.
OBJECTIVE
The long-term outcome of transplanted kidneys has not changed substantially and only a minority of grafts survives more than 15 yr. The aim of this study was to determine the influence of ACE gene polymorphism on long-term outcome after renal transplantation.


METHODS
Using PCR, we evaluated ACE I/D gene polymorphism in a group of patients with long-term graft function (LTF) over 15 yr and compared it with control groups of transplant recipients and population sample.


RESULTS
The distribution of genotypes in the LTF group differed from transplant controls (p < 0.05). Moreover, DD homozygotes in the LTF group had better creatinine clearance (DD: 1.1 +/- 0.3, ID: 0.96 +/- 0.3, II: 0.76 +/- 0.3 mL/s; p < 0.05). There were no differences in genotype distribution between transplant and population samples.


CONCLUSIONS
Results of our study have demonstrated a possible connection between the DD variant of ACE I/D gene polymorphism and excellent long-term graft function.
Viklický
O
O
Department of Nephrology, Transplant Center, Institute for Clinical and Experimental Medicine, Vídenská 1958/9, 14021 4, Prague, Czech Republic. ondrej.viklicky@medicon.cz
Hubácek
J A
JA
Pitha
J
J
Teplan
V
V
Heemann
U W
UW
Lácha
J
J
Vítko
S
S
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000652:urine; D005260:Female; D005838:Genotype; D006801:Humans; D016030:Kidney Transplantation / Q000379:methods* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013997:Time Factors; D016896:Treatment Outcome
D003404:Creatinine; D007703:Peptidyl-Dipeptidase A