[Inhibitory effect of matrine on lipopolysacchride-induced tumor necrosis factor and interleukin-6 production from rat Kupffer cells].
The effect of matrine on the lipopolysacchride (LPS)-induced tumor necrosis factor and interleukin-6 production from rat Kupffer cell was investigated. Results showed that matrine 125, 250 and 500 mg.L-1 suppressed TNF and IL-6 production from Cal-primed Kupffer cells in the presence of lipopolysacchrides (LPS, 100 micrograms.L-1) in a concentration-dependent manner. Treatment with matrine 50 and 100 mg.kg-1 before LPS injection(3.5 mg.kg-1) markedly decreased mouse serum TNF and IL-6. The results suggest that matrine may have protective effect on LPS-induced liver injury.
Research Laboratory of Natural and Synthetic Drugs, College of Pharmacy, Second Military Medical University, Shanghai 200433.
W
W
Lin
J P
JP
Zhang
Z L
ZL
Hu
D H
DH
Qian
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D005260:Female; D015850:Interleukin-6 / Q000097:blood / Q000378:metabolism*; D007728:Kupffer Cells / Q000378:metabolism*; D008070:Lipopolysaccharides; D051379:Mice; D008813:Mice, Inbred ICR; D011807:Quinolizines; D051381:Rats; D017208:Rats, Wistar; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D000093842:Matrines
D000470:Alkaloids; D015850:Interleukin-6; D008070:Lipopolysaccharides; D011807:Quinolizines; D014409:Tumor Necrosis Factor-alpha; D000093842:Matrines