In vitro metabolism of citalopram by monoamine oxidase B in human blood.
The metabolism of the antidepressant citalopram (CIT) by monoamine oxidase B (MAO-B) was studied in vitro. In incubations with blood of nine healthy volunteers R-(P=0.015) and S-(P=0.0034) CIT propionic acid (CITPROP) production was correlated with the number of platelets. S-CITPROP production was 5.6 times higher than R-CITPROP production and in incubations containing the MAO-B inhibitor deprenyl, racemic CITPROP production was diminished to 9.1%. To our knowledge, this is the first time that MAO-B activity in blood is shown with an antidepressant as substrate. As MAO is strongly expressed in human brain, this observation suggests that this enzymatic system may be implicated in drug metabolism in the CNS.
Kosel
M
M
Unité de Biochimie et Psychopharmacologie Clinique, Département Universitaire de Psychiatrie Adulte, CH-1008 Prilly-Lausanne, Switzerland.
Amey
M
M
Aubert
A C
AC
Baumann
P
P
D000928:Antidepressive Agents / Q000097:blood*; D015283:Citalopram / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D008995:Monoamine Oxidase / Q000097:blood*; D010976:Platelet Count; D012016:Reference Values
D000928:Antidepressive Agents; D015283:Citalopram; D008995:Monoamine Oxidase