Serum cholesteryl ester transfer protein concentrations in healthy Chinese subjects and cardio-cerebrovascular disease patients.
Serum cholesteryl ester transfer protein (CETP) concentration was measured in 1128 healthy Chinese subjects using a "sandwich" enzyme immunoassay and was 1.84 +/- 1.55 mg/l (mean +/- S.D.). The frequency distribution of CETP in healthy subjects was markedly skewed towards low concentrations. The CETP concentration in females was significantly higher than that in males (2.40 +/- 1.65 mg/l vs. 1.49 +/- 1.37 mg/l, P < 0.001). There was a weak inverse correlation between the CETP concentration and age (r = -0.19, P < 0.001). The CETP concentrations were significantly higher in 117 myocardial infarction (MI) survivors and 110 stroke patients than that in 335 healthy, age-matched males (1.98 +/- 1.68 173 +/- 1.45, and 1.40 +/- 1.37 mg/l respectively, P < 0.01), while no relation was found between CETP concentration and lipids concentration in MI, stroke and healthy group.
Zhuang
Y
Y
Biochemistry Laboratory, Jinling Hospital, Clinical School of Medical College, Nanjing University, 305 East Zhongshan Road, 210002, Nanjing, PR China.YYZhuang@public1.ptt.is.cn
Wang
J
J
Qiang
H
H
Li
Y
Y
Lui
X
X
Li
L
L
Chen
G
G
D002318:Cardiovascular Diseases / Q000097:blood* / Q000208:ethnology; D002352:Carrier Proteins / Q000097:blood*; D016022:Case-Control Studies; D002561:Cerebrovascular Disorders / Q000097:blood* / Q000208:ethnology; D002681:China; D053480:Cholesterol Ester Transfer Proteins; D005260:Female; D006023:Glycoproteins; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male
C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D006023:Glycoproteins; D008055:Lipids