Synthesis, characterisation, X-ray structure and biological activity of three new 5-formyluracil thiosemicarbazone complexes.
Three new complexes of transition metals as copper, nickel and cobalt with 5-formyluracil thiosemicarbazone (H3ut) have been synthesised and characterised by single-crystal X-ray diffraction. In all compounds the ligand behaves as SNO terdentate. In the copper complex the coordination geometry is square pyramidal with the ligand lying on the basal plane and two water molecules that complete the metal environment, the nickel compound is surrounded by six donor atoms (three of the ligand, two water oxygen atoms and a chlorine atom) in an octahedral fashion, and cobalt also shows an octahedral geometry but determined only by two terdentate ligand molecules. These three compounds have been tested on human leukemic cell lines K562 and CEM. The nickel and cobalt complexes have demonstrated low activity in cell growth, while the copper complex that is more active has been tested also on a third leukemic human cell line (U937), but it was not able to induce apoptosis on all cell lines.
Dipartimento di Chimica Generale ed Inorganica, Chimica Analitica, Chimica Fisica, Centro di Studio per la Strutturistica Diffrattometrica del CNR, University of Parma, Italy. chimic8@ipruniv.cce.unipr.it
M B
MB
Ferrari
F
F
Bisceglie
G
G
Pelosi
P
P
Tarasconi
R
R
Albertin
A
A
Bonati
P
P
Lunghi
S
S
Pinelli
D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects*; D003035:Cobalt / Q000737:chemistry / Q000494:pharmacology; D003300:Copper / Q000737:chemistry / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D008024:Ligands; D015394:Molecular Structure; D009153:Mutagens / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009532:Nickel / Q000737:chemistry / Q000494:pharmacology; D013882:Thiosemicarbazones / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*
D008024:Ligands; D009153:Mutagens; D013882:Thiosemicarbazones; C007777:5-formyluracil; D003035:Cobalt; D014498:Uracil; D003300:Copper; D009532:Nickel