Restoring blood pressure reperfused Wernicke's area and improved language.
Longitudinal clinical and imaging data from a patient who sustained a left frontal-temporal stroke with hypoperfusion of the adjacent Wernicke's area are reported. His language deficits were partially ameliorated by pharmacologically increasing his blood pressure, and were exacerbated when blood pressure dropped. There was a striking temporal and statistical correlation between mean arterial pressure and language accuracy. MR perfusion imaging showed that language gains were accompanied by improved perfusion of Wernicke's area when mean arterial pressure was increased.
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. argye@JHMI.edu
A E
AE
Hillis
P B
PB
Barker
N J
NJ
Beauchamp
B D
BD
Winters
M
M
Mirski
R J
RJ
Wityk
D001794:Blood Pressure / Q000502:physiology*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000473:pathology / Q000503:physiopathology*; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology*