Ophthalmic drops causing coma in an infant.
A 1-month-old infant with Peters anomaly had recurrent episodes of unresponsiveness, hypotension, hypotonia, hypothermia, and bradycardia. An extensive medical evaluation determined these episodes to be caused by brimonidine, an anti-glaucoma agent. There is the potential for serious toxic effects from the systemic absorption of topically applied ophthalmic agents in children.
Berlin
R J
RJ
Oregon Poison Center, Department of Emergency Medicine, Oregon Health Sciences University, Portland, 97207, USA.
Lee
U T
UT
Samples
J R
JR
Rich
L F
LF
Tang-Liu
D D
DD
Sing
K A
KA
Steiner
R D
RD
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000506:poisoning*; D000068438:Brimonidine Tartrate; D003128:Coma / Q000150:complications / Q000209:etiology* / Q000517:prevention & control; D005124:Eye Abnormalities / Q000150:complications; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009883:Ophthalmic Solutions / Q000008:administration & dosage / Q000506:poisoning*; D017410:Practice Guidelines as Topic; D011810:Quinoxalines / Q000008:administration & dosage / Q000506:poisoning*; D013577:Syndrome
D000316:Adrenergic alpha-Agonists; D009883:Ophthalmic Solutions; D011810:Quinoxalines; D000068438:Brimonidine Tartrate