Peptide-mediated cellular delivery.
Peptide-mediated molecular therapeutic delivery systems have recently emerged as an alternative means to effectively substitute or augment present gene therapy technologies, e.g., TAT, VP22, engineered peptides. These systems show great promise for the elimination of the main bottleneck to safe, efficient, targeted gene therapy delivery and are able to efficiently introduce DNA, antisense peptide nucleic acids, oligonucleotides, small molecules and proteins into cells both in vitro and in vivo. They are versatile and easily designed to incorporate a number of specific attributes required for efficient cargo delivery. A fundamentally new property of these moieties will allow the therapeutic intervention in the biochemistry of the target cell without the need to alter its genome.
Center for Biomedical Engineering 56-341, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, MA 02139-4307, USA. jschwart@MIT.EDU
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D000818:Animals; D051943:Antennapedia Homeodomain Protein; D016503:Drug Delivery Systems; D015696:Gene Products, tat / Q000008:administration & dosage / Q000235:genetics; D015316:Genetic Therapy / Q000379:methods*; D018398:Homeodomain Proteins / Q000008:administration & dosage / Q000235:genetics; D006801:Humans; D009687:Nuclear Proteins; D010455:Peptides / Q000008:administration & dosage* / Q000235:genetics*; D014157:Transcription Factors; D014764:Viral Proteins / Q000008:administration & dosage / Q000235:genetics
D051943:Antennapedia Homeodomain Protein; D015696:Gene Products, tat; D018398:Homeodomain Proteins; C054582:ICP35 protein, Human herpesvirus 1; D009687:Nuclear Proteins; D010455:Peptides; D014157:Transcription Factors; D014764:Viral Proteins