Interference with the formation of the epididymal microenvironment--a new strategy for male contraception?
The cystic fibrosis transmembrane conductance regulator (CFTR) or the small conductance cAMP-activated chloride channel encoded by the CFTR gene has been shown to play an important role in the formation of the epididymal fluid microenvironment. Recent work in our laboratory has shown that this protein is also expressed by developing germ cells indicating a role of this protein in spermatogenesis. In view of the fact that the CFTR gene has a far reaching and widespread effect on human reproduction, understanding the role of CFTR in the male reproductive tissues and its intervention by pharmacological agents can open a new avenue of research into the development of novel male contraceptives.
Gong
X D
XD
Department of Physiology, Chinese University of Hong Kong, Shatin, N. T., Hong Kong, China.
Leung
G P
GP
Cheuk
B L
BL
Wong
P Y
PY
D000818:Animals; D003267:Contraception / Q000379:methods*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000502:physiology; D004573:Electrolytes / Q000378:metabolism; D004822:Epididymis / Q000502:physiology*; D006801:Humans; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology
C505032:CFTR protein, human; D004573:Electrolytes; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D011451:Prostaglandin-Endoperoxide Synthases