Novel synthetic analogue of ACTH 4-10 (Semax) but not glycine prevents the enhanced nitric oxide generation in cerebral cortex of rats with incomplete global ischemia.
This work investigates whether nitric oxide production and lipid peroxidation contribute to the pathophysiology of ischemia and whether glycine and a novel Russian compound, Semax are neuroprotective via a mechanism involving the regulation nitric oxide (NO) and lipid peroxidation. In brief, nitric oxide and indices of lipid peroxidation were elevated following global ischemia. While glycine proved ineffective in reducing NO levels or ameliorating the neurological deficits following global ischemia, Semax proved to be highly effective in abating the rise in nitric oxide and restoring neurologic functioning.
Bashkatova
V G
VG
Institute of Pharmacology, Russian Academy of Medical Sciences, 8 Baltiyskaya Street, 125315, Moscow, Russia.
Koshelev
V B
VB
Fadyukova
O E
OE
Alexeev
A A
AA
Vanin
A F
AF
Rayevsky
K S
KS
Ashmarin
I P
IP
Armstrong
D M
DM
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D005998:Glycine / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D018697:Nootropic Agents / Q000494:pharmacology*; D010446:Peptide Fragments / Q000737:chemistry / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D018697:Nootropic Agents; D010446:Peptide Fragments; D009569:Nitric Oxide; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone; C011394:ACTH (4-10); D005998:Glycine