A case of obesity, diabetes and hypertension treated with very low calorie diet (VLCD) followed by successful pregnancy with intrauterine insemination (IUI).
The patient was a 32-year-old obese woman with a history of type 2 diabetes and hypertension for 6 years. Although she was treated with antihypertensive agents and intensive insulin therapy, her hyperglycemia was difficult to control. She wanted to have a baby but pregnancy was not recommended because her diabetes was under poor control and the use of antihypertensive medication. To achieve good control of obesity, diabetes and hypertension, she was admitted to our clinical department for weight reduction using very low calorie diet (VLCD). During VLCD she had a 19.8 kg reduction in body weight and her blood glucose and blood pressure were in good control without the use of drugs. Five months later, she became pregnant after the fourth trial of intrauterine insemination (IUI) and gave birth to a female baby under insulin therapy. This is the first report that showed the usefulness of VLCD for prepregnant control of glucose metabolism and blood pressure in an obese hypertensive patient with type 2 diabetes mellitus.
Third Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
A
A
Katsuki
Y
Y
Sumida
K
K
Ito
S
S
Murashima
E C
EC
Gabazza
M
M
Furuta
Y
Y
Yano
T
T
Sugiyama
N
N
Toyoda
Y
Y
Adachi
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000178:diet therapy*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000178:diet therapy*; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D015309:Glucose Clamp Technique; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000178:diet therapy*; D007247:Infertility, Female / Q000628:therapy; D007315:Insemination, Artificial; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D007333:Insulin Resistance; D009765:Obesity; D011247:Pregnancy; D015431:Weight Loss
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin