[Physiology and pharmacology of lacrymal and salivary secretions].
Salivary and lacrymal glands have secretory mechanisms similar to those of other exocrine glands. Saliva results from two different but integrated processes i.e. hydroelectrolytic transport and protein secretion by regulated exocytosis. Both cellular processes are regulated by the autonomic nervous system with complementary effects without antagonism, and parasympathetic innervation predominates. Signal transduction mechanisms in salivary cells include: increases in cytosolic calcium, cyclic AMP and cyclic GMP. The tear film consists of three layers: mucous inner layer, middle aqueous layer, and outer lipid layer. Each layer secretion is strongly regulated. Aqueous layer secretion is controlled by autonomic nervous system and signal transduction depends from cyclic AMP and intracellular calcium levels. A review of drugs used in France modulating lacrymal and salivary secretions is proposed.
Tribout
B
B
Service de pharmacologie clinique Hôpital Sud, CHU Amiens 80054 Amiens.
Gras-Champel
V
V
Pannier
M
M
Andréjak
M
M
D000249:Adenosine Monophosphate / Q000502:physiology; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology; D002118:Calcium / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D005602:France; D006157:Guanosine Monophosphate / Q000502:physiology; D006801:Humans; D007424:Intracellular Fluid / Q000502:physiology; D010602:Pharmacopoeias as Topic; D012463:Saliva / Q000187:drug effects* / Q000502:physiology*; D015398:Signal Transduction; D013666:Tears / Q000187:drug effects* / Q000502:physiology*
D016207:Cytokines; D000249:Adenosine Monophosphate; D006157:Guanosine Monophosphate; D002118:Calcium