[Long-term effects of irradiation in the progeny of mammalian cells].
It is shown that gamma-irradiation has remote consequences for mammalian cells cultivated in vitro. Many generations in the progeny of cells surviving acute and chronic irradiation at high and low doses are characterized by a number of abnormalities, including delayed cell death, the formation of micronuclei and giant cells, an increased frequency of sister chromatid exchanges, a reduced potential for repair, the loss of adaptive response, and increased radiosensitivity. These phenomena are regarded as manifestations of genomic instability induced by ionizing radiation.
Semenov Institute of Chemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977 Russia.
I I
II
Pelevina
V Ia
VIa
Gotlib
O V
OV
Kudriashova
M M
MM
Antoshchina
D000818:Animals; D016923:Cell Death / Q000528:radiation effects*; D002467:Cell Nucleus / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts; D005720:Gamma Rays; D006367:HeLa Cells; D006801:Humans; D015162:Micronucleus Tests; D011836:Radiation Tolerance; D013997:Time Factors