Pregnancy in premature ovarian failure: a possible role of estrogen plus progesterone treatment.
Premature ovarian failure (POF) is a common occurrence in women during their reproductive years. There is paucity of data on spontaneous ovulation and subsequent pregnancies in such women. In this report, we describe three women with POF, two of whom had spontaneous conceptions and the third resumed spontaneous regular menstrual cycles. All these women had received oestrogen-progesterone tablets for many cycles (ethyl oestradiol 0.05 mg and levonorgestrel 0.25 mg a day, 21 days a month). We speculate about the possibility of elevated gonadotrophins causing down regulation of gonadotrophin receptors and restoration of the sensitivity of the few remaining ovarian follicles by lowering of serum gonadotrophins with oestrogen therapy.
Department of Endocrinology, Sher-i-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
A H
AH
Zargar
M
M
Salahuddin
A I
AI
Wani
M I
MI
Bashir
S R
SR
Masoodi
B A
BA
Laway
D000328:Adult; D045166:Estradiol Congeners / Q000627:therapeutic use*; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D016912:Levonorgestrel / Q000627:therapeutic use*; D011247:Pregnancy; D016649:Primary Ovarian Insufficiency / Q000188:drug therapy* / Q000503:physiopathology*; D045167:Progesterone Congeners / Q000627:therapeutic use*
D045166:Estradiol Congeners; D045167:Progesterone Congeners; D004997:Ethinyl Estradiol; D016912:Levonorgestrel