[Imiquimod: a new treatment possibility in bowenoid papulosis?].
Bowenoid papulosis is a highly characteristic condition of the anogenital region which is histologically similar to bowenoid carcinoma in situ. Some evidence suggests a viral origin on the basis of infection with high-risk oncogenic genotypes of human papilloma viruses (HPV 16/18 and others) and an association with cervical carcinoma. Malignant transformation is rare in bowenoid papulosis. The condition usually shows a good response to immuno-modulatory treatment. In the following we present our first case of successful treatment with imiquimod, a topical immune response modifier which is successfully used in the USA for local treatment of condylomata acuminata. Imiquimod creme (Aldara) proved to be a safe, efficious and practical patient-applied therapeutic option for the treatment of bowenoid papulosis. In view of the oncogenic potential of high-risk HPV infections, irrespective of the treatment used, all patients with bowenoid papulosis and their sexual partners must be included in long-term follow-up and regularly examined for malignant transformation.
Universitäts-Hautklinik Münster, Von-Esmarch-Strasse 56, 48149 Münster.
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D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000634:Aminoquinolines / Q000008:administration & dosage / Q000627:therapeutic use*; D001706:Biopsy; D001913:Bowen's Disease / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D000077271:Imiquimod; D007369:Interferon Inducers / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009824:Ointments; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D010409:Penile Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D012307:Risk Factors; D012747:Sexual Partners; D015229:Sexually Transmitted Diseases, Viral / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000473:pathology; D017444:Skin Diseases, Papulosquamous / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis / Q000473:pathology; D013997:Time Factors; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000473:pathology
D000276:Adjuvants, Immunologic; D000634:Aminoquinolines; D007369:Interferon Inducers; D009824:Ointments; D000077271:Imiquimod