BACE1 is the major beta-secretase for generation of Abeta peptides by neurons.
Cai
H
H
Department of Pathology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Wang
Y
Y
McCarthy
D
D
Wen
H
H
Borchelt
D R
DR
Price
D L
DL
Wong
P C
PC
D000544:Alzheimer Disease / Q000378:metabolism*; D053829:Amyloid Precursor Protein Secretases; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism; D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000378:metabolism*; D002478:Cells, Cultured; D010450:Endopeptidases; D051379:Mice; D018345:Mice, Knockout / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*
D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D053829:Amyloid Precursor Protein Secretases; D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; C509282:Bace1 protein, mouse