Proportion of infiltrating IgG-binding immune cells predict for tumour hypoxia.
Macrophages can account for up to 50% of tumour mass and secrete many angiogenic factors. Furthermore, tumour hypoxia is thought to play a major role in the activation of macrophages and the regulation of angiogenesis. In this paper, we demonstrate a strong correlation between hypoxia and the recruitment of immune cells binding to IgG in 8 experimental tumours. We provide evidence that IgG binding immune cells in 3 tumour lines are predominately composed of macrophages. Reduced oxygenation may act as a stimulus for recruitment of immune cells to the tumour mass, and the detection of either IgG-positive host cells or macrophages may offer an alternative method for monitoring tumour hypoxia.
PET Oncology Group, Imperial College School of Medicine, Hammersmith Hospital, MRC Cyclotron Building, Du Cane Road, London, W12 0NN, UK.
D R
DR
Collingridge
S A
SA
Hill
D J
DJ
Chaplin
D000818:Animals; D015687:Cell Hypoxia; D005260:Female; D005434:Flow Cytometry; D005544:Forecasting; D007074:Immunoglobulin G / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000276:immunology*; D014407:Tumor Cells, Cultured
D007074:Immunoglobulin G