Immunity against cancer: lessons learned from melanoma.
Most major advances in human cancer immunology and immunotherapy have come from studies in melanoma. We are beginning to understand the immune repertoire of T cells and antibodies that are active against melanoma, with recent glimpses of the CD4(+) T cell repertoire. The view of what the immune system can see is extending to mutations and parts of the genome that are normally invisible.
Memorial Sloan-Kettering Cancer Center and Weill Medical School of Cornell University, 1275 York Avenue, New York, NY 10021, USA. a-houghton@ski.mskcc.org
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Houghton
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Gold
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Blachere
D000818:Animals; D000943:Antigens, Differentiation / Q000276:immunology; D000951:Antigens, Neoplasm / Q000235:genetics / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics / Q000276:immunology*; D013736:Testicular Neoplasms / Q000276:immunology; D014611:Vaccination
D000943:Antigens, Differentiation; D000951:Antigens, Neoplasm; D019496:Cancer Vaccines