Thickness shear mode resonators ("mass-sensitive devices") in bioanalysis.
A short overview of function and experimental set-ups of acoustic wave devices is given which, in contrast to other bioanalysis techniques, are based on a mechanical transduction mechanism. The most frequently used device is the thickness shear mode resonator (TSMR), which in the last few years was intensively employed in biosensor applications. TSMR biosensor studies in the field of nucleic acid interaction, adsorption of proteins to surfaces and immunosensing are reviewed. A main point concerns the interpretation of the sensor response not only in terms of mass loading, which underestimates the capabilities of these devices.
Kaspar
M
M
Institute of Physical and Theoretical Chemistry, University of Tübingen, Germany.
Stadler
H
H
Weiss
T
T
Ziegler
C
C
D000162:Acoustics; D000818:Animals; D000906:Antibodies / Q000737:chemistry; D001703:Biophysics / Q000295:instrumentation* / Q000379:methods*; D015374:Biosensing Techniques / Q000295:instrumentation*; D006801:Humans; D009696:Nucleic Acids / Q000737:chemistry; D014160:Transducers, Pressure
D000906:Antibodies; D009696:Nucleic Acids