Determination of oxymetazoline hydrochloride and decomposition products by high-performance liquid chromatography.
An HPLC method for the separation of the oxymetazoline hydrochloride and the products of its decomposition was developed and validated. The determination was performed with a LiChrospher RP-18 column, mobile phase of methanol-H2O-triethylamine-sodium acetate (1 mol l(-1))-acetic acid (1.06 kg l(-1)) (130:60:6:2:1). UV detector set at 280 nm and antazoline methanesulfonate as an internal standard.
Stanisz
B
B
Department of Pharmaceutical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
Nowiński
W
W
D000316:Adrenergic alpha-Agonists / Q000032:analysis*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D010109:Oxymetazoline / Q000032:analysis* / Q000737:chemistry
D000316:Adrenergic alpha-Agonists; D010109:Oxymetazoline