Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis.
The chemopreventive efficacy of lycopene and curcumin with regard to prostate carcinogenesis was investigated using 3,2'-dimethyl-4-aminobiphenol (DMAB)- and 2-amino-1-methylimidazo[4,5-b]pyridine (PhIP)-induced rat ventral prostate cancer models. Three 60 week experiments with male F344 rats were carried out. In the first DMAB was given for the first 20 weeks and lycopene or curcumin were administered concomitantly or subsequently at dietary doses of 15 and 500 p.p.m., respectively. In the second experiment lycopene and curcumin were given to rats pretreated with DMAB at doses of 5, 15 or 45 p.p.m. or 100 or 500 p.p.m. In the third PhIP was selected as an initiator for prostate carcinogenesis and administered for 20 weeks. Rats were then fed a diet containing lycopene at a dose of 45 p.p.m. or curcumin at a dose of 500 p.p.m. or both together. Chemopreventive effects of lycopene and curcumin on development of DMAB-induced ventral prostate carcinomas were observed only in the first experiment and no confirmation of inhibition potential was obtained in the following studies. Neither summational nor synergistic chemoprevention was evident. It is concluded from the present data that, overall, neither lycopene nor curcumin can consistently prevent rat prostate carcinogenesis.
Imaida
K
K
1st Department of Pathology Nagoya City University Medical School, 1-Kawasumi, Mizuho-ku, Nagoya 467-8601, Japan. imaida@med.nagoya-cu.ac.jp
Tamano
S
S
Kato
K
K
Ikeda
Y
Y
Asamoto
M
M
Takahashi
S
S
Nir
Z
Z
Murakoshi
M
M
Nishino
H
H
Shirai
T
T
D000611:Aminobiphenyl Compounds / Q000633:toxicity; D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002273:Carcinogens / Q000633:toxicity; D002338:Carotenoids / Q000494:pharmacology*; D003474:Curcumin / Q000494:pharmacology*; D007093:Imidazoles / Q000633:toxicity; D000077276:Lycopene; D008297:Male; D011471:Prostatic Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011916:Rats, Inbred F344
D000611:Aminobiphenyl Compounds; D016588:Anticarcinogenic Agents; D002273:Carcinogens; D007093:Imidazoles; C001042:2',3-dimethyl-4-aminobiphenyl; D002338:Carotenoids; C049584:2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine; D003474:Curcumin; D000077276:Lycopene