Interleukin-5: a drug target for allergic diseases.
There is a large body of evidence that eosinophils are a key component of the allergic response in asthma. Interleukin (IL) 5 is uniquely involved in the production of eosinophils, and with a variety of other cytokines and factors controls their activation, localization and survival. Thus, IL-5 is an important drug target for new anti-asthmatics. The routes to drug discovery are based on screens for inhibitors of IL-5 production, ligand antagonists, control of receptor expression and receptor activation. In this review, we will discuss specific targets and screening assays with examples of some of the compounds in development.
Sanderson
C J
CJ
Western Australian Institute for Medical Research & Curtin University of Technology, Level 5 MRF Building, Rear 50 Murray Street, Perth 6000, Australia. colin@cyllene.uwa.edu.au
Urwin
D
D
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D015848:Interleukin-5 / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000502:physiology*
D018926:Anti-Allergic Agents; D015848:Interleukin-5