Cytokine expression in the mouse brain in response to immune activation by Corynebacterium parvum.
Cytokine expression in the brain has been suggested to mediate various sickness behaviors. Here we report that intraperitoneal injection of a Corynebacterium parvum antigen in C57BL/6 mice was followed by prolonged upregulation of cytokines in the cerebral cortex and subcortical structures in a time course that coincided with reduced spontaneous running activity.
Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation, and the University of Minnesota Medical School, NeuroImmunology Lab D-305, 914 South 8th St., Minneapolis, MN 55404, USA. wsheng@biosci.cbs.umn.edu
W S
WS
Sheng
S
S
Hu
J M
JM
Ding
C C
CC
Chao
P K
PK
Peterson
D000818:Animals; D001522:Behavior, Animal; D001921:Brain / Q000276:immunology*; D003354:Corynebacterium Infections / Q000276:immunology*; D016207:Cytokines / Q000235:genetics* / Q000276:immunology; D004195:Disease Models, Animal; D005221:Fatigue / Q000276:immunology; D015870:Gene Expression / Q000276:immunology; D007375:Interleukin-1 / Q000235:genetics / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000276:immunology; D011425:Propionibacterium acnes / Q000276:immunology*; D012333:RNA, Messenger / Q000032:analysis; D017472:Receptors, Interleukin-1 / Q000235:genetics / Q000276:immunology; D018124:Receptors, Tumor Necrosis Factor / Q000235:genetics / Q000276:immunology; D016212:Transforming Growth Factor beta / Q000235:genetics / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics / Q000276:immunology
D016207:Cytokines; D007375:Interleukin-1; D012333:RNA, Messenger; D017472:Receptors, Interleukin-1; D018124:Receptors, Tumor Necrosis Factor; D016212:Transforming Growth Factor beta; D014409:Tumor Necrosis Factor-alpha