Membrane transport: retromer to the rescue.
Genetic analysis in yeast has led to the discovery of a complex that retrieves proteins selectively from the prevacuolar compartment and transports them to the Golgi. Orthologs of these proteins in mammalian cells are likely to play a similar role but their cargoes are yet to be identified.
Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305-5307, USA. pfeffer@cmgm.stanford.edu
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D000818:Animals; D002451:Cell Compartmentation; D002462:Cell Membrane / Q000378:metabolism*; D005656:Fungal Proteins / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D021381:Protein Transport; D011956:Receptors, Cell Surface / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins
D005656:Fungal Proteins; C087335:PEP1 protein, S cerevisiae; D011956:Receptors, Cell Surface; D029701:Saccharomyces cerevisiae Proteins; D033921:Vesicular Transport Proteins