Molecular changes associated with prostate cancer development.
The epidemiologic characteristics of prostate cancer (PCa) have been recognized for several decades. It is of great importance to understand the factors responsible for prostate carcinogenesis, why some carcinomas remain "clinically silent" during life, whereas other tumors progress to present clinically and may lead to PCa-related death. A better understanding of these mechanisms in molecular genetic terms should point to more rational approaches to disease prevention, intervention and treatment. The aim of this review is to provide a comprehensive overview of the current state of knowledge regarding the molecular alterations of PCa.
Department of Pathology, University Hospital Nijmegen, P. O. Box 9101, 6500 HB, Nijmegen, The Netherlands. e.ruijter@pathol.azn.nl
E
E
Ruijter
R
R
Montironi
C
C
van de Kaa
J
J
Schalken
D000728:Androgens / Q000378:metabolism; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D019175:DNA Methylation; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D009376:Neoplasms, Hormone-Dependent / Q000473:pathology; D009857:Oncogenes; D011471:Prostatic Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D015398:Signal Transduction; D019098:Telomerase / Q000378:metabolism; D014807:Vitamin D
D000728:Androgens; D014807:Vitamin D; D019098:Telomerase