Colchicine induced rhabdomyolysis.
A case of colchicine induced rhabdomyolysis is reported. A 73 year old man with ischaemic heart disease, atrial fibrillation, chronic congestive cardiac failure, and chronic gout presented with diffuse muscle pain. He had been taking an increased dose of colchicine (1.5 mg daily) for an exacerbation of gout for six weeks before the presentation. Investigations confirmed the diagnosis of rhabdomyolysis and discontinuation of colchicine resulted in resolution of clinical and biochemical features of rhabdomyolysis. Although neuromuscular adverse effects of colchicine are well recognised, rhabdomyolysis is rare and this is only the fourth reported case of colchicine induced rhabdomyolysis in the literature.
Chattopadhyay
I
I
Department of Geriatric Medicine, Ysbyty Gwynedd Hospital, Bangor, UK.
Shetty
H G
HG
Routledge
P A
PA
Jeffery
J
J
D000368:Aged; D003078:Colchicine / Q000009:adverse effects*; D006073:Gout / Q000188:drug therapy*; D006074:Gout Suppressants / Q000009:adverse effects*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D016896:Treatment Outcome
D006074:Gout Suppressants; D003078:Colchicine