Different patterns of autobiographical memory loss in semantic dementia and medial temporal lobe amnesia: a challenge to consolidation theory.
Temporally graded retrograde memory loss, with a disproportionate impairment of recent relative to remote memories, is considered a hallmark of medial temporal lobe amnesia. According to consolidation theory, the hippocampal complex, which includes the hippocampal formation, parahippocampal gyrus, the entorhinal and perirhinal cortex, plays a time-limited role in memory, needed only until consolidation in the neocortex is complete (Squire, Psychological Review 1992; 99: 195-231). Recent support for this theory comes from findings of a reverse gradient in people with semantic dementia with neocortical degeneration but a relatively preserved hippocampal complex (Hodges and Graham, Neuropsychologia 1998; 36: 803-25). Consolidation theory is challenged by evidence that remote autobiographical memory is not always spared in amnesia (Nadel and Moscovitch, Current Opinion in Neurobiology 1997; 7: 217-27) and that semantic memory becomes highly personalized in semantic dementia (Snowden et al., Memory 1995; 3: 225-46). According to Nadel and Moscovitch, the hippocampal complex is needed to retain and retrieve detailed memories of autobiographical episodes no matter how old they are. To test consolidation theory against the opposing view, we investigated the role of the hippocampal complex in recent and remote autobiographical and personal semantic memory by contrasting the memory of a semantic dementia patient, EL, with that of an amnesic patient, KC, using family photographs as recall cues. KC demonstrated a complete loss of autobiographical episodes with a sparing of autobiographical facts; EL demonstrated well-preserved memory for episodes with a reverse gradient for personally relevant names. The influence of autobiographical significance on memory for names of public figures was examined further by comparing the effect that familiarity and recollection had on recognition of names of famous people and famous places. EL's memory was influenced by autobiographical significance, whereas KC's was not. We propose that the hippocampal complex plays a permanent role in the storage and retrieval of autobiographical episodes and that autobiographical significance may affect semantic representations.
Department of Psychology, University of Toronto, Toronto, Ontario, Canada. robyn@psych.utoronto.ca
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R
Westmacott
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Leach
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Freedman
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Moscovitch
D000368:Aged; D000648:Amnesia, Retrograde / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D003704:Dementia / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D006624:Hippocampus / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000150:complications* / Q000473:pathology / Q000503:physiopathology*; D008875:Middle Aged; D021641:Recognition, Psychology / Q000502:physiology; D013647:Task Performance and Analysis; D013702:Temporal Lobe / Q000473:pathology / Q000503:physiopathology*