Effects of S-21007, a potent 5-HT3 partial agonist, in mouse anxiety.
OBJECTIVE
To study the effect of S-21007, a 5-HT3 partial agonist in different animal models of anxiety in mice.


METHODS
S-21007 effects were evaluated in the behavior tests after intraperitoneal and oral acute treatment or in the light/dark test after both acute and chronic treatments.


RESULTS
S-21007 presented anxiolytic-like properties after acute administration in the light/dark box test, the mirrored chamber test, and the elevated plus-maze at low doses 10 ng.kg(-1)-100 micrograms.kg-1, 1-100 micrograms.kg-1 and 10-100 micrograms.kg-1, respectively. In the light/dark box test, S-21007 was active orally after acute treatment at 100 ng.kg(-1)-10 mg.kg-1 and after chronic treatment (14 d) at 1-10 micrograms.kg-1. S-21007 was devoid of sedative or stimulatory effects.


CONCLUSIONS
S-21007 exhibited anxiolytic-like properties. The mechanism of action may be a desensitization of 5-HT3 receptor or an antagonist activity on the 5-HT3 receptors.
Delagrange
P
P
Institut de Recherches Internationales Servier, 92415 Courbevoie, France. librext@francenet.fr
Misslin
R
R
Seale
T W
TW
Pfeiffer
B
B
Rault
S
S
Renard
P
P
D000818:Animals; D001007:Anxiety; D001522:Behavior, Animal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010879:Piperazines / Q000494:pharmacology*; D011719:Pyrazines / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects; D044406:Receptors, Serotonin, 5-HT3; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D010879:Piperazines; D011719:Pyrazines; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; C106046:S 21007; D017366:Serotonin Receptor Agonists