Antiproliferative effects of allium derivatives from garlic.
There is increasing evidence that allium derivatives from garlic have significant antiproliferative actions on human cancers. Both hormone-responsive and hormone-unresponsive cells lines respond to these derivatives. The effects shown by allium derivatives include induction of apoptosis, regulation of cell cycle progression and modification of pathways of signal transduction. Allium derivatives appear to regulate nuclear factors involved in immune function and inflammation, as well as in cellular proliferation. Our own studies indicate that allium derivatives inhibit proliferation of the human prostate cancer cell line (LNCaP) and the human breast cancer cell line (MCF-7). Further research is required to clarify the mechanisms of inhibition of cellular proliferation by allium derivatives and to explore their potential application to cancer prevention and control.
Pinto
J T
JT
Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. pintoj@mskcc.org
Rivlin
R S
RS
D000490:Allium / Q000737:chemistry; D000498:Allyl Compounds / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D005260:Female; D005737:Garlic / Q000737:chemistry*; D006801:Humans; D008297:Male; D010946:Plants, Medicinal; D011471:Prostatic Neoplasms / Q000473:pathology; D015398:Signal Transduction; D013440:Sulfides / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000498:Allyl Compounds; D000970:Antineoplastic Agents; D013440:Sulfides; C038491:allyl sulfide