A case of systemic lupus erythematosus complicated with multicentric reticulohistiocytosis (MRH): successful treatment of MRH and lupus nephritis with cyclosporin A.
We document the first case of a patient who manifested systemic lupus erythematosus (SLE) complicated with multicentric reticulohistiocytosis (MRH). Neither intravenous steroid nor cyclophosphamide (CY) pulse therapies were fully effective against multiple MRH-related tumors that appeared on the left ankle joint and interphalangeal joints of both hands. In contrast, treatment with cyclosporin A (CyA) resulted in a marked regression of these nodules within one month, together with a complete remission of both MRH and lupus nephritis. We propose CyA as an alternative choice for the treatment of MRH.
The First Department of Internal Medicine, University of Occupational and Environmental Health, School of Medicine, Japan. kazu-s@med.uoeh-u.ac.jp
K
K
Saito
K
K
Fujii
Y
Y
Awazu
S
S
Nakayamada
Y
Y
Fujii
T
T
Ota
Y
Y
Tanaka
D000328:Adult; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D015614:Histiocytosis / Q000150:complications*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy*
D018501:Antirheumatic Agents; D016572:Cyclosporine