Regulation of molecular motor proteins.
Motor proteins in the kinesin, dynein, and myosin superfamilies are tightly regulated to perform multiple functions in the cell requiring force generation. Although motor proteins within families are diverse in sequence and structure, there are general mechanisms by which they are regulated. We first discuss the regulation of the subset of kinesin family members for which such information exists, and then address general mechanisms of kinesin family regulation. We review what is known about the regulation of axonemal and cytoplasmic dyneins. Recent work on cytoplasmic dynein has revealed the existence of multiple isoforms for each dynein chain, making the study of dynein regulation more complicated than previously realized. Finally, we discuss the regulation of myosins known to be involved in membrane trafficking. Myosins and kinesins may be evolutionarily related, and there are common themes of regulation between these two classes of motors.
Department of Cell and Structural Biology, University of Illinois, Urbana-Champaign, Urbana 61801, USA.
A R
AR
Reilein
S L
SL
Rogers
M C
MC
Tuma
V I
VI
Gelfand
D000818:Animals; D001692:Biological Transport; D004398:Dyneins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D016547:Kinesins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D020409:Molecular Motor Proteins / Q000378:metabolism*; D009218:Myosins / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D015388:Organelles / Q000378:metabolism
D020409:Molecular Motor Proteins; D009218:Myosins; D004398:Dyneins; D016547:Kinesins