Cytochrome P4501A1 polymorphisms in South American Indians.
A total of 131 individuals from five Brazilian Indian tribes were studied for two CYP1A1 gene polymorphisms. The presence of the *val allele at codon 462 varied from 54% in the Surui to 97% in the Xavante, while the presence of the MspI restriction site (*m2 allele) at position T6235C ranged from 72% in the Gavião to 95% in the Xavante. The haplotypes derived from these two sites showed a highly heterogeneous distribution among the five populations. The most common haplotype in South Amerindians was *val/*m2 (54% to 94%). This prevalence is the highest that has been observed in any world population.
Departamento de Genética, Instituto De Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
K
K
Kvitko
J C
JC
Nunes
T A
TA
Weimer
F M
FM
Salzano
M H
MH
Hutz
D001938:Brazil; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005787:Gene Frequency; D006239:Haplotypes; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic
D003577:Cytochrome P-450 Enzyme System