[Interaction of DNA with benzocrown derivatives of actinocin].
Complexes of DNA with actinocin derivatives containing benzocrown groups at the 1 and/or 9 positions of the chromophore were studied by spectrophotometric titration and circular dichroism. The actinocin chromophore and the crown fragments are the binding sites of the ligands with DNA. The mode of ligand-DNA binding is shown to depend on the size of the crown group, its distance to the actinocin chromophore, and the ionic strength of the medium. Selective toward Na+ ion benzocrown fragments combine with DNA phosphate groups. The simultaneous interaction of the actinocin chromophore with the DNA bases is possible only at optimal distance between both the binding sites of ligand molecule.
E B
EB
Moroshkina
N V
NV
Zagoruĭko
E N
EN
Glibin
D001665:Binding Sites; D002942:Circular Dichroism; D004247:DNA / Q000378:metabolism*; D010078:Oxazines / Q000737:chemistry / Q000378:metabolism*
D010078:Oxazines; C006401:actinocin; D004247:DNA