Coadministration of mefloquine and chloroqine: use of a pharmacokinetic-based approach to reduce toxicity.
A child with malaria from a chloroquine-resistant area received an accidental overdose of chloroquine administered by a parent. Application of pharmacokinetics permitted definitive treatment with mefloquine in a safe and effective manner.
Division of Clinical Pharmacology and Toxicology, Children's Mercy Hospital and Clinics, Kansas City, MO 64108, USA.
J A
JA
Lowry
A
A
Corry
L
L
Fitzmaurice
M A
MA
Jackson
G L
GL
Kearns
D000962:Antimalarials / Q000009:adverse effects / Q000493:pharmacokinetics*; D002648:Child; D002738:Chloroquine / Q000009:adverse effects / Q000493:pharmacokinetics*; D062787:Drug Overdose; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D006801:Humans; D008288:Malaria / Q000188:drug therapy*; D008297:Male; D015767:Mefloquine / Q000493:pharmacokinetics*
D000962:Antimalarials; D002738:Chloroquine; D015767:Mefloquine