Fate of lipid hydroperoxides in blood plasma.
Cholesteryl ester hydroperoxide (CE-OOH) and phosphatidylcholine hydroperoxide (PC-OOH) are the major primary oxidation products of lipoproteins. CE-OOH is present in human and rat plasmas while PC-OOH is undetectable. This is likely due to the enzymatic (plasma glutathione peroxidase) and the nonenzymatic (apolipoproteins A and B-100) reducing activities of PC-OOH in plasma, and to the enzymatic conversion of PC-OOH to CE-OOH by lecithin:cholesterol acyltransferase in high density lipoproteins. The regioisomeric distribution of CE-O(O)H in human plasma indicates that free radical-mediated chain oxidation is an ongoing process, even in healthy young individuals.
Department of Chemistry and Biotechnology, Graduate School of Engineering, The University of Tokyo, Japan. junkan@oxygen.t.u-tokyo.ac.jp
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Yamamoto
D000818:Animals; D002788:Cholesterol Esters / Q000378:metabolism; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism
D002788:Cholesterol Esters; D008054:Lipid Peroxides; C021976:cholesteryl linoleate; D007862:Phosphatidylcholine-Sterol O-Acyltransferase