[Helicobacter pylori and antigastric autoimmunity].
Recent studies report a significant association between Helicobacter pylori gastritis and autoimmune reaction. Antigastric autoantibodies are detectable in about 30% of H. pylori infected patients. Two major in situ binding sites have been found: first, at the luminal membrane of the foveolar epithelium in antrum and corpus mucosa and, second, at canalicular membranes within parietal cells in the corpus mucosa. The presence of latter type of autoantibodies is correlated with histological and clinical parameters of corpus mucosa atrophy. The gastric H+/K(+)-ATPase, which is already known as an autoantigen in classic autoimmune gastritis, also represents a major target in atrophic H. pylori gastritis. According to recent data molecular mimicry between H. pylori and the host does not play a pathogenic role in the formation these autoantibodies. In conclusion, antigastric autoimmunity represents a relevant host factor which contributes to the final outcome of H. pylori gastritis.
Faller
G
G
Pathologisches Institut der Universität Erlangen-Nürnberg, Krankenhausstrasse 8-10, 91054 Erlangen. Gerhard.Faller@patho.imed.uni-erlangen.de
Kirchner
T
T
D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000382:microbiology* / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology; D005756:Gastritis / Q000276:immunology / Q000382:microbiology* / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D017506:H(+)-K(+)-Exchanging ATPase / Q000276:immunology; D016481:Helicobacter Infections / Q000276:immunology* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans
D001323:Autoantibodies; D017506:H(+)-K(+)-Exchanging ATPase