Independence of firing correlates of anatomically proximate hippocampal pyramidal cells.
In neocortex, neighboring neurons frequently exhibit correlated encoding properties. There is conflicting evidence whether a similar phenomenon occurs in hippocampus. To assess this quantitatively, a comparison was made of the spatial and temporal firing correlations within and between local groups of hippocampal cells, spaced 350-1400 microm apart. No evidence of clustering was found in a sample of >3000 neurons. Moreover, cells active in two environments were uniformly interspersed at a scale of <100 microm, as assessed by the activity-induced gene Arc. Independence of encoding characteristics implies uncorrelated inputs, which could enhance the capacity of the hippocampus to store arbitrary associations.
Division of Neural Systems, Memory, and Aging, Arizona Research Laboratories, University of Arizona, Tucson, Arizona 85724, USA.
A D
AD
Redish
F P
FP
Battaglia
M K
MK
Chawla
A D
AD
Ekstrom
J L
JL
Gerrard
P
P
Lipa
E S
ES
Rosenzweig
P F
PF
Worley
J F
JF
Guzowski
B L
BL
McNaughton
C A
CA
Barnes
D000200:Action Potentials / Q000502:physiology*; D000818:Animals; D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004777:Environment; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism*; D007395:Interneurons / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008474:Medial Forebrain Bundle / Q000502:physiology; D009043:Motor Activity / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D017966:Pyramidal Cells / Q000502:physiology*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344; D012815:Signal Processing, Computer-Assisted; D013037:Spatial Behavior / Q000502:physiology
D003598:Cytoskeletal Proteins; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; C092069:activity regulated cytoskeletal-associated protein