Fleroxacin uptake in ischaemic limb tissue.
Antibiotic application to patients with ischaemia of lower limbs may be indicated to avoid or treat infection of soft tissues. Fleroxacin, a fluoroquinolone, active against various Gram-negative and Gram-positive organisms may be used for this purpose. We evaluated the diffusion of fleroxacin into bone, subcutaneous fat, muscle and tendon tissues of lower limb tissue after a 400 mg i.v. dose. Concentrations in ischaemic tissues were similar to those found in non-ischaemic sites. Since the maximum antibiotic levels found were lower than the MICs of various pathogens relevant for infection, we suggest to increase the dose used for this peri-operative prophylaxis to 800 mg.
Department of Pharmacology, University of Padua, L.go E. Meneghetti, 2., 35131 Padova, Italy.
P A
PA
Miglioli
R
R
Kafka
H
H
Bonatti
G
G
Fraedrich
F
F
Allerberger
U
U
Schoeffel
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics*; D001842:Bone and Bones / Q000378:metabolism; D004058:Diffusion; D005121:Extremities; D005260:Female; D016576:Fleroxacin / Q000493:pharmacokinetics*; D007511:Ischemia / Q000378:metabolism*; D008297:Male; D018482:Muscle, Skeletal / Q000378:metabolism; D012756:Sheep; D013710:Tendons / Q000378:metabolism
D000890:Anti-Infective Agents; D016576:Fleroxacin