Plastic membrane electrode for the potentiometric determination of pethidine hydrochloride in pharmaceutical preparations.
A novel poly(vinyl chloride) membrane electrode with dibutyl phthalate as plasticizer based on the pethidine-tetraphenylborate ion-association complex as ion-exchange site for the determination of pethidine hydrochloride in injections and tablets was developed. A linear response for 1 x 10(-5) to 1 x 10(-2) mol/L drug with a slope of 51.77 mV/decade was established. The optimum pH range was 2-8. The lower detection limit was 2.18 x 10(-6) mol/L. There were negligible interferences from a number of inorganic and organic cations and some common drug excipients. The electrode proposed had been successfully applied to determine pethidine hydrochloride in tablets and injections. The results correlated well with those obtained by the United States Pharmacopoeia standard procedure.
Department of Chemistry, Yunnan University, Kunming, PR China.
Z H
ZH
Liu
M L
ML
Wen
Y
Y
Yao
J
J
Xiong
D002138:Calibration; D004563:Electrochemistry; D004566:Electrodes; D006863:Hydrogen-Ion Concentration; D007267:Injections; D007477:Ions / Q000009:adverse effects; D008567:Membranes, Artificial; D008614:Meperidine / Q000032:analysis* / Q000592:standards; D004364:Pharmaceutical Preparations / Q000032:analysis* / Q000592:standards; D011143:Polyvinyl Chloride / Q000737:chemistry; D011199:Potentiometry; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D013607:Tablets / Q000032:analysis
D007477:Ions; D008567:Membranes, Artificial; D004364:Pharmaceutical Preparations; D013607:Tablets; D011143:Polyvinyl Chloride; D008614:Meperidine