Affinity of polyphenols for lipid bilayers.
Interaction of tea catechins with lipid bilayers has been investigated with liposome systems. Epicatechin gallate had the highest affinity for lipid bilayers, followed by epigallocatechin gallate, epicatechin, and epigallocatechin. Epicatechin gallate and epigallocatechin gallate in the surface of lipid bilayer perturbed the membrane structure.
School of Food and Nutritional Sciences, University of Shizuoka, Japan.
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Nakayama
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Hashimoto
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Kajiya
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Kumazawa
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D002392:Catechin / Q000737:chemistry; D005419:Flavonoids; D008051:Lipid Bilayers / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013662:Tea; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D016588:Anticarcinogenic Agents; D005419:Flavonoids; D008051:Lipid Bilayers; D010636:Phenols; D011108:Polymers; D013662:Tea; D002392:Catechin