[Antisecretory effect of dl-(15R)-15 methyl-PGE2 methyl ester (PG6E) on perfusing rats in vivo].
The antisecretion effect of dl-(15R)-15 methyl-PGE2 methyl ester (PG6E) was studied in perfusing rats in vivo. The results showed that PG6E at the dose 0.1 mg.kg-1 decreased markedly the acid secretion and antagonized the gastric acid secretion induced by histamine, pilocarpin and pentagastrin in rats. This action of PG6E appeared to be similar to that of cimetidine (40 mg.kg-1).
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
R M
RM
Xu
S R
SR
Zhang
B Y
BY
Jin
C
C
Han
Y L
YL
Wu
D000818:Animals; D001101:Arbaprostil / Q000031:analogs & derivatives / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006633:Histamine Antagonists; D008297:Male; D010418:Pentagastrin / Q000037:antagonists & inhibitors; D010862:Pilocarpine / Q000037:antagonists & inhibitors; D051381:Rats
D005765:Gastrointestinal Agents; D006633:Histamine Antagonists; D010862:Pilocarpine; C117159:15-methylprostaglandin E2 methyl ester; D010418:Pentagastrin; D001101:Arbaprostil