Uncoupling protein 3 and peroxisome proliferator-activated receptor gamma2 contribute to obesity and diabetes in palauans.
We examined the genetic contribution of single nucleotide polymorphisms (SNPs) of the energy metabolism-related genes, including beta 3 adrenergic receptor (beta3AR), apolipoprotein E (apo-E), promoter of uncoupling protein 3 (UCP3-p), peroxisome proliferator-activated receptor gamma 2 (PPARgamma2) and leptin receptor (LEPR) to metabolic disorders, in 118 inhabitants of Palau. The data were statistically analyzed and ethnically compared to correlate SNPs and their metabolic parameters. UCP3-p (P < 0.01) and PPARgamma2 (p = 0.05) correlated with plasma HbA1c, and UCP3-p correlated with fasting blood glucose (P < 0.01) in males, but not in females. UCP3-p correlated with body fat (%) (P < 0.01) in females, but not in males. Plasma leptin levels and apo-E were correlated in both groups. The frequency of SNPs for PPARgamma2, LEPR, and UCP3-p are significantly different between Palauans and Caucasians.
Department of Medical Chemistry, Kagawa Nutrition University, Chiyoda Sakado, Saitama, 350-0288, Japan.
Y
Y
Yanagisawa
K
K
Hasegawa
G J
GJ
Dever
C T
CT
Otto
M
M
Sakuma
S
S
Shibata
S
S
Miyagi
Y
Y
Kaneko
Y
Y
Kagawa
D000273:Adipose Tissue; D044466:Asian People; D001483:Base Sequence; D001823:Body Composition; D002352:Carrier Proteins / Q000502:physiology*; D017931:DNA Primers; D005260:Female; D005838:Genotype; D006801:Humans; D007473:Ion Channels; D008297:Male; D008875:Middle Aged; D024101:Mitochondrial Proteins; D009765:Obesity / Q000208:ethnology / Q000503:physiopathology*; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology*; D014157:Transcription Factors / Q000502:physiology*; D000071247:Uncoupling Protein 3
D002352:Carrier Proteins; D017931:DNA Primers; D007473:Ion Channels; D024101:Mitochondrial Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; C000604392:UCP3 protein, human; D000071247:Uncoupling Protein 3