Unraveling the mechanisms by which heat shock proteins activate the immune system.
A role for heat shock proteins in eliciting CD8 cytotoxic T-lymphocyte (CTL) responses in the absence of exogenous adjuvants has been documented for some time. Only recently, however, has the mechanism by which these molecules are able to elicit such responses begun to be elucidated.
Center for Cancer Research and Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. dpp60@mit.edu
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D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis; D029721:Drosophila Proteins; D006360:Heat-Shock Proteins / Q000276:immunology* / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D007249:Inflammation / Q000209:etiology / Q000517:prevention & control; D018950:Lipopolysaccharide Receptors / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D051193:Toll-Like Receptors
D016207:Cytokines; D029721:Drosophila Proteins; D006360:Heat-Shock Proteins; D015395:Histocompatibility Antigens Class I; D018950:Lipopolysaccharide Receptors; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors