High dose chemotherapy with peripheral blood stem cell transplantation (PBSCT) in ovarian cancer.
Ovarian cancer is a very chemosensitive tumor, but survival is poor due to the emergence of drug resistance. It may be possible to overcome resistance by using high dose chemotherapy supported by peripheral blood stem cell transplantation. A review of retrospective studies of dose-intensity and phase I/II high dose chemotherapy trials, and an analysis of the EBMT registry data is used as evidence to support the case for dose-intensification in ovarian cancer. As a result of this analysis there are now prospective randomized trials of high dose chemotherapy in ovarian cancer.
Ledermann
Jonathan A
JA
EBMT Trials, CRC and UCL Cancer Trials Center, Department of Oncology, University College London, UK.