Erythrocytic vacuolar rafts induced by malaria parasites.
Studies in the past year displaced long-standing dogmas and provided many new molecular insights into how proteins and solutes move between the erythrocyte plasma membrane and the malarial vacuole. Highlights include a demonstration that (1) detergent-resistant membrane (DRM) rafts exist in the red cell membrane and their resident proteins are detected as rafts in the plasmodial vacuole, (2) a voltage-gated channel in the infected red cell membrane mediates uptake of extracellular nutrient solutes, and (3) intraerythrocytic membranes transport a parasite-encoded adherence antigen to the red cell surface.
Haldar
K
K
Departments of Pathology and Microbiology-Immunology, Northwestern University, Chicago, Illinois, USA. k-haldar@nwu.edu
Samuel
B U
BU
Mohandas
N
N
Harrison
T
T
Hiller
N L
NL
D000818:Animals; D001692:Biological Transport; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000469:parasitology; D004912:Erythrocytes / Q000378:metabolism* / Q000469:parasitology; D006801:Humans; D008288:Malaria / Q000469:parasitology; D010961:Plasmodium / Q000378:metabolism; D014617:Vacuoles / Q000378:metabolism* / Q000469:parasitology