Studies on gynaecological hydrophilic lactic acid preparations. Part 4: Effects of polyvinyl pyrrolidone K-90 on properties of methylcellulose gels.
In continuing the investigation of the binding of lactic acid with basic polymers polyvinyl pyrrolidone K-90 (PVP) was used. Use of PVP in mixtures with lactic acid in experimentally determined and calculated proportions allowed the preparation of gels with pH 3.8-4.4, i.e. maintaining the physiological conditions in the vagina. The viscosity of the methylcellulose gels increases proportionally to the amount of the PVP--lactic acid complex added. Examination of the gels in the biopharmaceutical model, which simulated the physiological conditions of the vagina, allowed determination of the mobility of the preparations in patients.
Department of Pharmaceutical Technology, Faculty of Pharmacy, Wrocław Medical University, Wrocław, Poland.
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Małolepsza-Jarmołowska
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Kubis
D005782:Gels; D006863:Hydrogen-Ion Concentration; D019344:Lactic Acid / Q000008:administration & dosage* / Q000737:chemistry*; D008747:Methylcellulose; D010592:Pharmaceutic Aids / Q000737:chemistry*; D011205:Povidone / Q000737:chemistry*; D014783:Viscosity
D005782:Gels; D010592:Pharmaceutic Aids; D019344:Lactic Acid; D008747:Methylcellulose; D011205:Povidone