[Febrile convulsions, Treatment and prognosis].
Epidemiological data indicate that the long-term prognosis in the vast majority of children with febrile seizures is good. Three main problems are important for the treatment: febrile seizures are extremely upsetting for the parents, the recurrence rate is 30-40% and the febrile status occurs unpredictably and is potentially damaging to the CNS. There is universal agreement that daily prophylaxis with valproate, primidone, or phenobarbital should only be used in highly selected cases, if at all. The effectiveness of phenytoin and carbamazepine has not been documented. Antipyretic treatment does not reduce the recurrence rate. Intermittent diazepam prophylaxis at times of fever may or may not reduce the recurrence rate significantly, but there is no data to suggest that it improves the long-term outcome, as compared with short-term seizure control, in terms of IQ, cognition, academic progress, motor control, and subsequent epilepsy. Acute anticonvulsive treatment with rectal diazepam in solution or other benzodiazepines is effective in aborting recurrent seizures with almost the effectiveness of i.v. treatment and is safe, simple, and easy to use for the parents. The long-term prognosis is probably uninfluenced by the type of treatment given in early childhood. It has not been established that acute anticonvulsive treatment with benzodiazepine is better than placebo.
Børneafdeling L, Amtssygehuset i Glostrup.
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Knudsen
D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects; D000927:Anticonvulsants / Q000008:administration & dosage* / Q000009:adverse effects; D002675:Child, Preschool; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects; D004827:Epilepsy / Q000209:etiology; D006801:Humans; D007223:Infant; D010634:Phenobarbital / Q000008:administration & dosage / Q000009:adverse effects; D011324:Primidone / Q000008:administration & dosage / Q000009:adverse effects; D011379:Prognosis; D012008:Recurrence; D003294:Seizures, Febrile / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D013997:Time Factors; D014635:Valproic Acid / Q000008:administration & dosage / Q000009:adverse effects
D018712:Analgesics, Non-Narcotic; D000927:Anticonvulsants; D011324:Primidone; D014635:Valproic Acid; D003975:Diazepam; D010634:Phenobarbital