Making decisions through Myc.
c-Myc is a transcriptional regulator involved in carcinogenesis through its role in growth control and cell cycle progression. Here we attempt to relate its role in stimulating the G1-S transition to the ability to affect functioning of key cell cycle regulators, and we focus on how its property of modulating transcription of a wide range of target genes could explain its capacity to affect multiple pathways leading to proliferation, apoptosis, growth, and transformation.
Nasi
S
S
Centro Acidi Nucleici CNR, Dipartimento di Genetica e Biologia Molecolare, Università La Sapienza, P.le A. Moro 5, 00185, Rome, Italy. s.nasi@caspur.it
Ciarapica
R
R
Jucker
R
R
Rosati
J
J
Soucek
L
L
D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D018797:Cell Cycle Proteins / Q000378:metabolism; D002455:Cell Division / Q000235:genetics; D018844:Cyclin-Dependent Kinases / Q000378:metabolism; D016213:Cyclins / Q000378:metabolism; D016193:G1 Phase / Q000235:genetics; D005786:Gene Expression Regulation; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D016196:S Phase / Q000235:genetics; D014158:Transcription, Genetic
D018797:Cell Cycle Proteins; D016213:Cyclins; D016271:Proto-Oncogene Proteins c-myc; D018844:Cyclin-Dependent Kinases