Transdominant genetics, peptide inhibitors and drug targets.
The future of medical therapy is tied to the discovery of high-quality drug targets and drugs. Transdominant genetics provides a function-based route to peptide inhibitors that can be used as probes to identify protein targets or as reagents for drug development. Both forward-genetic and reverse-genetic applications have been implemented. The move is now underway to expand upon advances made in model systems and exploit screens of real therapeutic value.
Arcaris Inc, 615 Arapeen Dr, Suite 300, Salt Lake City, UT 84108, USA. kamb@arcaris.com
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D000818:Animals; D015195:Drug Design; D005799:Genes, Dominant / Q000187:drug effects; D005821:Genetic Techniques; D006801:Humans; D008958:Models, Molecular; D010455:Peptides / Q000737:chemistry / Q000235:genetics / Q000494:pharmacology*; D010641:Phenotype; D011506:Proteins / Q000037:antagonists & inhibitors / Q000235:genetics
D010455:Peptides; D011506:Proteins