Evaluation of electrophoretic method versus chromatographic, potentiometric and absorptiometric methodologies for determing pK(a) values of quinolones in hydroorganic mixtures.
The advantages of using capillary electrophoresis (CE) over other methodologies for determining pK(a) values of drugs in hydroorganic media are discussed. The focus of the discussion based upon the pK(a) values of a series of quinolones determined in acetonitrile (MeCN)--water mixtures by CE, liquid chromatography, potentiometric, and spectrophotometric methods.
Department of Analytical Chemistry, University of Barcelona, Martí i Franquès, 1-11, 08028 Barcelona, Spain. barbosa@zeus.qui.ub.es
J
J
Barbosa
D
D
Barrón
J
J
Cano
E
E
Jiménez-Lozano
V
V
Sanz-Nebot
I
I
Toro
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000032:analysis* / Q000737:chemistry; D002853:Chromatography, Liquid / Q000379:methods*; D019075:Electrophoresis, Capillary / Q000379:methods* / Q000592:standards; D009930:Organic Chemicals / Q000737:chemistry*; D011199:Potentiometry / Q000379:methods*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*
D042462:4-Quinolones; D000890:Anti-Infective Agents; D009930:Organic Chemicals