Analgesic and anti-inflammatory effects of phosphodiesterase inhibitors.
The aim of the present study was to investigate the role of phosphodiesterase (PDE) enzyme inhibitors namely rolipram and theophylline in pain and inflammation in experimental animals. Rolipram, a selective PDE IV inhibitor and theophylline a nonspecific PDE inhibitor exerted dose dependent analgesic and anti-inflammatory effect against acetic acid-induced writhing in mice and carrageenan-induced paw edema in rats, respectively. Nimesulide (1, 2 mg/kg) produced significant anti-inflammatory effect. Further, nimesulide (0.5 mg/kg) potentiated analgesic effect of rolipram but it failed to modulate the anti-inflammatory effect of PDE inhibitors. Present study suggests that PDE enzymes might be playing a role in nociceptive and inflammatory responses in animals.
Pharmacology Division, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh 160 014, India.
A
A
Kumar
N K
NK
Jain
S K
SK
Kulkarni
D015746:Abdominal Pain / Q000139:chemically induced / Q000188:drug therapy / Q000201:enzymology; D019342:Acetic Acid / Q000633:toxicity; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004487:Edema / Q000150:complications; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000188:drug therapy / Q000201:enzymology / Q000209:etiology; D010147:Pain Measurement; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D010727:Phosphoric Diester Hydrolases / Q000502:physiology*; D020889:Rolipram / Q000494:pharmacology / Q000627:therapeutic use*; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use*; D013806:Theophylline / Q000494:pharmacology / Q000627:therapeutic use*
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010726:Phosphodiesterase Inhibitors; D013449:Sulfonamides; D002351:Carrageenan; D013806:Theophylline; D010727:Phosphoric Diester Hydrolases; D020889:Rolipram; D019342:Acetic Acid; C012655:nimesulide