Experimental examination of a targeted hyperthermia system using inductively heated ferromagnetic microspheres in rabbit kidney.
It is known that significant heating can be generated by magnetic hysteresis effects in small ferromagnetic particles exposed to a rapidly alternating magnetic field. If such particles can be made to infiltrate the vascular bed surrounding a tumour by intravascular infusion then it may be possible to generate sufficient heating to destroy the tumour by hyperthermia. One of the constraints on such a technique is the limited amount of magnetic material that can be delivered to a tumour via the intravascular route and the consequent heating that can be induced by this material. Here, we report on a series of experiments in which doses of microspheres containing different amounts of ferromagnetic material were infused into rabbit kidneys via the renal artery with the aim of testing whether adequate tissue heating could be achieved using realistic concentrations of the embolised material. Heating rates were measured for each infused quantity under similar conditions with the animal alive and dead to examine the role of blood flow in the heating process. The results show that tissue temperatures above the therapeutic threshold of 42 degrees C can be readily achieved using this method with clinically relevant concentrations of microspheres in living tissue.
Jones
S K
SK
Cancer Research Institute Incorporated, Victoria Park, WA, Australia. sjones@sirtex.com
Winter
J G
JG
D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D005290:Ferric Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D007261:Infusions, Intra-Arterial; D007668:Kidney / Q000378:metabolism; D008280:Magnetics / Q000627:therapeutic use; D008863:Microspheres; D023421:Models, Animal; D009369:Neoplasms / Q000628:therapy; D011817:Rabbits; D012077:Renal Artery; D014018:Tissue Distribution
D005290:Ferric Compounds; C001215:ferrite