Study of iron metabolism abnormality in the hepatocyte damage of hepatitis B.
OBJECTIVE
To study the effect of iron metabolism on patients with hepatitis B.


METHODS
Hemoglobin (Hb), serum ferritin (SF), transferritin (TRF), serum iron (SI), and total iron binding capacity (TIBC) were detected in 103 patients with hepatitis B and 20 healthy adults.


RESULTS
The severer the hepatocyte damage was, the higher the SF, SI and the lower the Hb, TRF, and TIBC were. Furthermore, it seems more obvious among fulminant hepatitis and liver cirrhosis.


CONCLUSIONS
The overload of iron may enhance the hepatocyte damage induced by HBV. Therefore, to detect serum markers of iron metabolism is helpful to evaluate curative effect and prognosis of hepatitis B.
Third Hospital of Hebei Medical University, Shijiazhuang 050051, China.
Z
Z
Cao
Y
Y
Bai
X
X
Yang
J
J
Liu
B
B
Li
F
F
Li
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005293:Ferritins / Q000097:blood; D006454:Hemoglobins / Q000032:analysis; D006509:Hepatitis B / Q000378:metabolism* / Q000473:pathology; D022781:Hepatocytes / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008875:Middle Aged
D006454:Hemoglobins; D005293:Ferritins; D007501:Iron