Malignant pleural mesothelioma produces functional granulocyte-colony stimulating factor.
We report a patient with diffuse malignant pleural mesothelioma showing marked elevation of neutrophils. The level of serum granulocyte-colony stimulating factor (G-CSF) was elevated (138 pg/mL; normal range, < 20 pg/mL). The patient died 6 weeks after disease progression had been noted, and immunohistochemistry using a specific monoclonal antibody against recombinant G-CSF at autopsy demonstrated that the malignant mesothelioma cells actually produced G-CSF. Only three cases of malignant pleural mesothelioma, including the current patient, have been reported to produce G-CSF. We demonstrated an elevated serum level of G-CSF and G-CSF-bearing tumor cells by immunochemistry.
First Department of Internal Medicine, Tokyo Medical University, Tokyo, Japan.
I
I
Kasuga
S
S
Ishizuka
K
K
Minemura
K
K
Utsumi
H
H
Serizawa
K
K
Ohyashiki
D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008654:Mesothelioma / Q000378:metabolism*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000378:metabolism*
D016179:Granulocyte Colony-Stimulating Factor