[Optimization of aerosol therapy in otorhinolaryngology: stability and granulometry of dexamethasone-gomenol-framycetin solution].
Nebulization of solutions associating gomenol, dexamethasone and framycetin is very widespread in otorhinolaryngology (particularly for the treatment of actue laryngitis and post-traumatic laryngitis and rhinitis and for the tracheotomy care). A rigorous clinical evaluation is however lacking. The aim of this work was to evaluate use of such solutions in comparison with the recommendations issuing from the National Session in April 1997 on good practices for aerosol therapeutics. Stability and granulometry were studied in order to optimize processing. A new formulation and new technical methods of administration are proposed in relation to the results of this study and the national recommendations.
Bellanger
A
A
Pharmacie GH Pitié-Salpêtrière, 47 bd de l'Hôpital, 75651 Paris, Cedex 13.
Becquemin
M H
MH
Feldman
D
D
Bertholon
J F
JF
Tankere
F
F
D000336:Aerosols; D003907:Dexamethasone / Q000008:administration & dosage / Q000737:chemistry*; D004338:Drug Combinations; D004355:Drug Stability; D005601:Framycetin / Q000008:administration & dosage / Q000737:chemistry*; D009330:Nebulizers and Vaporizers; D010038:Otorhinolaryngologic Diseases / Q000188:drug therapy; D012996:Solutions; D013729:Terpenes / Q000008:administration & dosage / Q000737:chemistry*
D000336:Aerosols; D004338:Drug Combinations; D012996:Solutions; D013729:Terpenes; D005601:Framycetin; D003907:Dexamethasone; C013545:gomenol