Biochemical profile of erythrocyte membrane of jaundiced neonates.
Studies in newborn humans have demonstrated alteration in the lipid, phospholipid and cholesterol content when compared with age-matched control. Membrane bound (Na+ + K+)ATPase activity is found to be significantly increased in jaundiced neonates. Alteration in membrane permeability characteristics in jaundiced neonates causes severe microenvironmental changes in red blood cell profile.
Department of Biochemistry, Institute of Child Health, Calcutta, India.
S
S
Mazumder
U
U
Sarkar
D
D
Sengupta
D001724:Birth Weight; D002463:Cell Membrane Permeability; D002784:Cholesterol / Q000097:blood; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000737:chemistry* / Q000201:enzymology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007567:Jaundice, Neonatal / Q000097:blood*; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D008565:Membrane Proteins / Q000097:blood; D010042:Ouabain / Q000494:pharmacology; D010743:Phospholipids / Q000097:blood; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000097:blood
D004791:Enzyme Inhibitors; D008563:Membrane Lipids; D008565:Membrane Proteins; D010743:Phospholipids; D010042:Ouabain; D002784:Cholesterol; D000254:Sodium-Potassium-Exchanging ATPase