[Association between insertion-deletion polymorphism of the angiotensin-converting enzyme gene and development of angiopathies in patients with non-insulin dependent diabetes mellitus from the Chuvash Republic].
Insertion/deletion polymorphism of the angiotensin-converting enzyme (ACE) gene was analyzed in patients with non-insulin-dependent diabetes mellitus (NIDDM) and in the control group consisting of healthy subjects. The insertion allele (I) and genotype II were found to be associated with NIDDM. The frequencies of diabetic retinopathy and nephropathy in NIDDM patients were not associated with this polymorphism. However, an association was found between the DD genotype of the ACE gene and diabetic angiopathy in lower extremities.
Miloserdova
O V
OV
Institute of Molecular Genetics, Russian Academy of Sciences, Moscow, 123182 Russia.
Slominskiĭ
P A
PA
Mauianov
I V
IV
Markov
D S
DS
Balabolkin
M I
MI
Limborskaia
S A
SA
D003924:Diabetes Mellitus, Type 2 / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012426:Russia
D007703:Peptidyl-Dipeptidase A