Intracervical fibrin sealants: a potential treatment for early preterm premature rupture of the membranes.
OBJECTIVE
We report our experience with a transvaginally applied intracervical fibrin sealant at <24 weeks' gestation.


METHODS
This is an observational study of a referred patient population, with preterm premature rupture of the membranes at <24 weeks' gestation.


RESULTS
Twelve women consented to our protocol. The mean gestational age at preterm premature rupture of membranes was 19 weeks 4 days (range, 13-23 weeks); the mean gestational age at treatment was 20 weeks 5 days (range, 17-23 weeks). All women had a diminution in the amount of amniotic fluid leakage with an increase in amniotic fluid index. Among the 12 pregnancies (13 fetuses), there were 7 surviving neonates. Two women had apparent "resealing" of the membranes.


CONCLUSIONS
Fibrin sealants in midtrimester rupture of the membranes may lead to improved outcomes and now warrant formal evaluation.
Sciscione
A C
AC
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Christiana Care Health Services, Newark, Delaware 19718, USA.
Manley
J S
JS
Pollock
M
M
Maas
B
B
Shlossman
P A
PA
Mulla
W
W
Lankiewicz
M
M
Colmorgen
G H
GH
D000328:Adult; D000653:Amniotic Fluid / Q000000981:diagnostic imaging / Q000502:physiology; D001510:Bed Rest; D002584:Cervix Uteri / Q000473:pathology; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications / Q000628:therapy*; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000627:therapeutic use*; D005865:Gestational Age; D006801:Humans; D016104:Oligohydramnios / Q000150:complications; D010865:Pilot Projects; D011247:Pregnancy; D011256:Pregnancy Outcome; D014463:Ultrasonography
D015718:Fibrin Tissue Adhesive