[Risk for schizophrenia and diagnostic image of cerebral membrane metabolism].
In recent years neurobiological research on the etiology of schizophrenia has became increasingly important. In terms of a vulnerability-stress model, structural and functional cerebral alterations in schizophrenics and subjects with a genetic risk for schizophrenia are presented together with hypotheses for disturbances of neurodevelopment or neurodegeneration developed from these implications. A detailed description follows of a neurobiochemical paradigm on the disturbance of metabolism of membrane-phospholipids. 31Phosphorous Magnetic Resonance Spectroscopy allows the detection of indicators of this possible endo-phenotype. The possibilities and limitations of this method are explained, as are findings up to the present. Finally, it is discussed that specific pre-, peri- and postnatal influences on the cerebral metabolism of lipids, and thus on cerebral development, may be related to structural and functional cerebral changes in schizophrenia.
Klinik für Kinder- und Jugendpsychiatrie der Friedrich-Schiller-Universität Jena. Silke-Klemm@med.uni-jena.de
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S
Klemm
U J
UJ
Gerhard
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B
Blanz
D015415:Biomarkers; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008563:Membrane Lipids / Q000378:metabolism*; D008959:Models, Neurological; D010743:Phospholipids / Q000378:metabolism; D010759:Phosphorus Isotopes; D011877:Radionuclide Imaging; D012307:Risk Factors; D012559:Schizophrenia / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology
D015415:Biomarkers; D008563:Membrane Lipids; D010743:Phospholipids; D010759:Phosphorus Isotopes