Pathophysiological relevance of mitochondria in NAD(+) metabolism.
Pyridine nucleotides are mostly stored within mitochondria where they are involved in different functions ranging from energy metabolism to cellular signaling. Here we discuss the mechanisms of mitochondrial NAD(+) metabolism and release that may contribute to the crucial roles played by these organelles as triggers or amplifiers of physiological and pathological events.
Dipartment de Chimica Biologica, Università di Padova, Italy. dilisa@civ.bio.unipd.it
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Di Lisa
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Ziegler
D017209:Apoptosis; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D015398:Signal Transduction
D009243:NAD; D009249:NADP