Borna disease virus.
Borna disease virus (BDV) is unique amongst animal RNA viruses in its molecular biology and capacity to cause persistent, noncytolytic CNS-infection in a wide variety of host species. Unlike other non-segmented negative-strand RNA animal viruses, BDV replicates in the nucleus of the host cell where splicing is employed for expression of a very compact genome. Epidemiological studies indicate a broad host range and geographical distribution, and some investigators have proposed that human infection may result in neuropsychiatric disorders. Experimental Borna disease in neonatal and adult rats provides an intriguing model for immune-mediated disturbances of brain development and function.
Jordan
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Emerging Diseases Laboratory, Department of Neurology, University of California-- Irvine, Irvine, California 92697-4292, USA.
Lipkin
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D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral; D001890:Borna Disease / Q000097:blood / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D001891:Borna disease virus / Q000145:classification / Q000235:genetics / Q000276:immunology; D002493:Central Nervous System Diseases / Q000097:blood / Q000473:pathology / Q000821:virology; D002531:Cerebellum / Q000473:pathology / Q000821:virology; D004195:Disease Models, Animal; D016679:Genome, Viral; D006624:Hippocampus / Q000473:pathology / Q000821:virology; D006801:Humans; D007111:Immunity, Cellular; D008253:Macaca mulatta / Q000821:virology; D001523:Mental Disorders / Q000097:blood / Q000821:virology; D051379:Mice; D015995:Prevalence; D051381:Rats; D011443:Strepsirhini / Q000821:virology
D000914:Antibodies, Viral