Autoantibodies in atopic dermatitis.
Recent progress in the autoimmune aspects of atopic dermatitis has clarified that patients with atopic dermatitis develop IgE-class autoantibodies mainly against intracellular proteins. The cloning of cDNAs encoding autoallergens with human expression cDNA libraries and serum IgE from atopic dermatitis patients has unraveled the molecular characteristics of IgE-binding autoantigens. Some patients with atopic dermatitis also have IgG-class autoantibodies, especially anti-nuclear antibodies. One of the nuclear autoantigens was identified as DFS70/transcription coactivator p75. In addition, p80-coilin in nuclear coiled bodies is also targetted. Several lines of evidence suggest that a subset of atopic dermatitis may be associated with an autoimmune response.
Division of Connective Tissue Disease & Autoimmunity, Department of Dermatology, Graduate School of Medicine, Nagoya University, 65 Tsurumai-cho, Showa-ku, 466-8550, Nagoya, Japan. ymuro@med.nagoya-u.ac.jp
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D048868:Adaptor Proteins, Signal Transducing; D000888:Antibodies, Anti-Idiotypic / Q000097:blood; D000974:Antibodies, Antinuclear / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D001324:Autoantigens / Q000235:genetics; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D003876:Dermatitis, Atopic / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood / Q000235:genetics; D007074:Immunoglobulin G / Q000097:blood; D009687:Nuclear Proteins / Q000235:genetics / Q000276:immunology; D015534:Trans-Activators / Q000235:genetics / Q000276:immunology; D014157:Transcription Factors
D048868:Adaptor Proteins, Signal Transducing; D000888:Antibodies, Anti-Idiotypic; D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D001324:Autoantigens; D018076:DNA, Complementary; D007074:Immunoglobulin G; D009687:Nuclear Proteins; C504649:PSIP1 protein, human; D015534:Trans-Activators; D014157:Transcription Factors; C068921:p80-coilin; D007073:Immunoglobulin E