Monoamine oxidase B inhibitors from the fruits of Opuntia ficus-indica var. saboten.
Three varieties of methyl citrate and 1-methyl malate were isolated from the fruits of Opuntia ficus-indica var. saboten Makino through in vitro bioassay-guided isolation for the inhibition on monoamine oxidase(MAO). The IC50 values for MAO-B of 1-monomethyl citrate, 1,3-dimethyl citrate, trimethyl citrate and 1-methyl malate were 0.19, 0.23, 0.61 and 0.25 mM, respectively. However, on MAO-A, their inhibitions showed only marginal activity.
Natural Products Research Institute, Seoul National University, Korea. snake@snu.ac.kr
Y N
YN
Han
Y
Y
Choo
Y C
YC
Lee
Y I
YI
Moon
S D
SD
Kim
J W
JW
Choi
D019343:Citric Acid / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002957:Citrus / Q000737:chemistry*; D008995:Monoamine Oxidase / Q000187:drug effects*; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D008996:Monoamine Oxidase Inhibitors; D019343:Citric Acid; D008995:Monoamine Oxidase