The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.
We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and problem-solving was simplified by containment within local regions. The maps currently represent more than 94% of the euchromatic (gene-containing) regions of these chromosomes in 176 contigs, and contain 96% of the chromosome-specific markers in the human gene map. By measuring the remaining gaps, we can assess chromosome length and coverage in sequenced clones.
The Sanger Centre, Hinxton, Cambridge, UK. drb@sanger.ac.uk
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D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002882:Chromosomes, Human, Pair 13; D002890:Chromosomes, Human, Pair 20; D002896:Chromosomes, Human, Pair 6; D020451:Contig Mapping; D015894:Genome, Human; D006801:Humans; D014960:X Chromosome