Microcystin contamination in fish from the Jacarepaguá Lagoon (Rio de Janeiro, Brazil): ecological implication and human health risk.
Chronic and subchronic toxicity from exposure to microcystins, cyclic peptide liver toxins from certain cyanobacteria, poses an important hazard, which has received little study. No in vivo information exists on accumulation and transfer of microcystin from the food chain to humans. This paper present results of a 3-year study that demonstrates bioaccumulation of microcystins by fish and potential rates of microcystin ingestion by humans. The study was carried out in a shallow coastal lagoon in the city of Rio de Janeiro (Jacarepaguá Lagoon). Fish (Tilapia rendalli) were collected every 2 weeks from August 1996 to November 1999. Microcystins were analyzed by HPLC in phytoplankton, fish liver and viscera while fish muscle tissue was analyzed by enzyme linked immunosorbant assay (ELISA). Phytoplankton samples, dominated by the genus Microcystis, were confirmed to contain microcystins as were fish livers, viscera and muscle tissue. During the entire study period, including times of low water bloom densities, fish muscle tissue contained concentrations of microcystins close to or above the recommended limit for human consumption (0.04 microg x kg(-1) day). Our findings demonstrate that microcystins can accumulate in fish tissue used for human consumption. Rates of ingestion routinely exceed the TDI guidelines as set by the WHO for drinking water. Appropriate epidemiology and risk assessment should be undertaken so that an acceptable TDI and appropriate risk management decisions can be made for human consumption of fish which are harvested from cyanobacterial blooms that contain cyanotoxins.
Universidade Federal do Rio de Janeiro-CCS-NPPN-Laboratório de Ecofisiologia e Toxicologia de Cianobactérias, cep: 21941-590, Rio de Janeiro, Brazil. valeria@nppn.ufrj.br
V F
VF
Magalhães
R M
RM
Soares
S M
SM
Azevedo
D000818:Animals; D001938:Brazil / Q000453:epidemiology; D002851:Chromatography, High Pressure Liquid; D004463:Ecology; D005517:Foodborne Diseases / Q000453:epidemiology*; D008099:Liver / Q000737:chemistry; D008387:Marine Toxins / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D052998:Microcystins; D010456:Peptides, Cyclic / Q000032:analysis / Q000378:metabolism* / Q000633:toxicity; D010933:Plankton / Q000737:chemistry; D018570:Risk Assessment; D012621:Seasons; D017210:Tilapia / Q000378:metabolism*
D008387:Marine Toxins; D052998:Microcystins; D010456:Peptides, Cyclic; C078588:microcystin