Pain modulation role of melatonin in eating disorders.
The objective of this study was to test the effect of melatonin on thermal pain threshold in female patients with eating disorders. Fourteen patients were included in the study. We found a parabolic relation between pain threshold and the content of urine sulfatoxymelatonin (r = 0.6299, P < 0.05). We can speculate that increase in severity of eating disorder pathology may decrease both the melatonin level and pain sensitivity. In contrast with expected melatonin analgesic effect, our results showed its possible normalizing influence as well on pathologically decreased pain sensitivity.
Department of Psychiatry, 1st Faculty of Medicine, Charles University Prague, Ke Karlovu 11, 12821 Prague 2, Czech Republic. hpap@mbox.cesnet.cz
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H
Papezová
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Yamamotová
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Nedvídková
D000328:Adult; D000856:Anorexia Nervosa / Q000150:complications* / Q000175:diagnosis / Q000534:rehabilitation; D002032:Bulimia / Q000150:complications* / Q000175:diagnosis / Q000534:rehabilitation; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay; D008550:Melatonin / Q000652:urine*; D010146:Pain / Q000175:diagnosis*; D010147:Pain Measurement; D017288:Pain Threshold; D011569:Psychiatric Status Rating Scales; D020886:Somatosensory Disorders / Q000150:complications / Q000175:diagnosis / Q000652:urine; D013997:Time Factors
D008550:Melatonin