Synthesis and anti-rhinovirus activity of 2-styrylchromones.
2-Styrylchromones were synthesized as vinylogues of 2-phenylchromones (flavones), a broad class of anti-rhinovirus compounds. The antiviral activity of 2-styrylchromones and 3-hydroxy-1-(2-hydroxyphenyl)-5-phenyl-2,4-pentadien-1-ones, which are intermediates in the synthesis, was evaluated against two selected serotypes of human rhinovirus, 1B and 14, by a plaque reduction assay in HeLa cell cultures. All of the compounds interfered with HRV 1B replication, with the exception of 3-hydroxy-1-(2-hydroxyphenyl)-5-(4-methoxyphenyl)-2,4-pentadien-1-one. The majority of derivatives were also found to be effective against serotype 14, often with a higher potency.
Desideri
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N
Department of Pharmaceutical Studies, School of Medicine University La Sapienza of Rome, Italy. nicoletta.desideri@uniroma1.it
Conti
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C
Mastromarino
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P
Mastropaolo
F
F
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D005419:Flavonoids / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D012229:Rhinovirus / Q000187:drug effects*
D000998:Antiviral Agents; D005419:Flavonoids