Human herpesvirus 8 infection and Kaposi's sarcoma among human immunodeficiency virus-infected and -uninfected women.
Little is known about the epidemiology of human herpesvirus 8 (HHV-8) infections among women. A cross-sectional study was conducted of HHV-8 infection among human immunodeficiency virus (HIV)-infected and high-risk HIV-uninfected women. Serological tests with noninduced (latent) and induced (lytic) HHV-8 antigens were used to detect infection among 2483 participants of a multisite cohort. Reactivity to latent antigen was present in 4.1% and to induced antigens in 12.0% of women. Seven of 8 women who reported Kaposi's sarcoma had HHV-8 antibodies. Among HIV-positive women, HHV-8 infection was associated with use of crack, cocaine, or heroin (76% vs. 65%; P<.001), past syphilis (29% vs. 20%; P<.001), an injection drug-using male sex partner (61% vs. 53%; P=.014), black race (P=.010), and enrollment site (P=.015). In multivariate analysis, HIV infection, older age, past syphilis, black race, and enrollment site were independently associated with HHV-8 infection. In this cohort of North American women, HHV-8 infection was associated with HIV infection, drug use, and risky sexual behavior.
University of California, San Francisco, Infectious Diseases Division, San Francisco, CA 94122, USA. ruthg@itsa.ucsf.edu
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D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002140:California / Q000453:epidemiology; D003042:Cocaine; D015331:Cohort Studies; D016578:Crack Cocaine; D003430:Cross-Sectional Studies; D004219:District of Columbia / Q000453:epidemiology; D005260:Female; D015658:HIV Infections / Q000150:complications*; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications*; D003932:Heroin; D006566:Herpesviridae Infections / Q000150:complications* / Q000453:epidemiology; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D009518:New York / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012514:Sarcoma, Kaposi / Q000150:complications* / Q000453:epidemiology; D016036:Seroepidemiologic Studies; D012737:Sex Factors; D015819:Substance Abuse, Intravenous; D013587:Syphilis / Q000150:complications
D000914:Antibodies, Viral; D016578:Crack Cocaine; D003932:Heroin; D003042:Cocaine