Aspects of the transport and delivery of antisense oligonucleotides.
This article will examine recent developments concerning the cellular uptake and subcellular trafficking of antisense oligonucleotides. It will also examine the merits of various delivery strategies for oligonucleotides. The use of conjugates of oligonucleotides with 'cell penetrating peptides' as a promising delivery technology will be emphasized.
Department of Pharmacology, University of North Carolina, Chapel Hill, NC 27599, USA. arjay@med.unc.edu
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D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D001693:Biological Transport, Active; D002352:Carrier Proteins / Q000378:metabolism; D016503:Drug Delivery Systems; D006801:Humans; D008051:Lipid Bilayers / Q000378:metabolism; D016376:Oligonucleotides, Antisense / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D002352:Carrier Proteins; D008051:Lipid Bilayers; D016376:Oligonucleotides, Antisense