A familial risk profile for osteoporosis.
OBJECTIVE
To describe genetic epidemiologic aspects of osteoporosis.


METHODS
69 patients with osteoporosis were interviewed regarding personal and family histories of osteoporosis and related fractures. Family history information was obtained on 421 first degree and 748 second degree relatives.


RESULTS
45% of cases reported a family history of osteoporosis. Familial cases were characterized neither by an earlier age of diagnosis nor by a greater degree of phenotypic severity. Empiric risks for osteoporosis were highest for mothers, 33%, and were 19% for sisters.


CONCLUSIONS
These results provide an initial genetic epidemiologic profile for osteoporosis and information useful for genetic counseling.
Department of Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
L B
LB
Henderson
J S
JS
Adams
D R
DR
Goldstein
G D
GD
Braunstein
J I
JI
Rotter
M T
MT
Scheuner
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D005192:Family Health; D005260:Female; D005820:Genetic Testing; D006801:Humans; D008297:Male; D008875:Middle Aged; D009035:Mothers; D009679:Nuclear Family; D010024:Osteoporosis / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors; D012737:Sex Factors; D044465:White People