Aldosterone synthase (CYP11B2) gene polymorphism and cerebral white matter hyperintensities.
The association between aldosterone synthase (CYP11B2) gene polymorphism and white matter hyperintensities seen on cerebral MRI was studied in a population-based sample of 829 individuals aged 63 to 75 years. The T allele was associated with the risk of severe white matter hyperintensities. Compared with the CC genotype, the adjusted OR for severe white matter hyperintensities was 4.61 (95% CI, 1.46 to 14.55) for the TT genotype and 2.45 (95% CI, 0.81 to 7.46) for the TC genotype in men. This association was independent of hypertension.
Institut National de la Santé et de la Recherche Médicale U360, Hôpital Pitié-Salpêtrière, Paris, France.
P
P
Verpillat
A
A
Alpérovitch
F
F
Cambien
V
V
Besançon
H
H
Desal
C
C
Tzourio
D000368:Aged; D001794:Blood Pressure / Q000235:genetics / Q000502:physiology; D001927:Brain Diseases / Q000235:genetics* / Q000503:physiopathology; D019405:Cytochrome P-450 CYP11B2 / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*
D019405:Cytochrome P-450 CYP11B2