Acetyltransferases and tumour suppression.
The acetyltransferase p300 was first identified associated with the adenoviral transforming protein E1A, suggesting a potential role for p300 in the regulation of cell proliferation. Direct evidence demonstrating a role for p300 in human tumours was lacking until the recently publication by Gayther et al, which strongly supports a role for p300 as a tumour suppressor. The authors identify truncating mutations associated with the loss or mutation of the second allele in both tumour samples and cell lines, suggesting that loss of p300 may play a role in the development of a subset of human cancers.
Regulation of Cell Growth Laboratory, NCI-FCRDC, Frederick, Maryland 21702-1201, USA. phillips@ncifcrf.gov
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D000107:Acetylation; D000123:Acetyltransferases / Q000235:genetics / Q000502:physiology*; D000256:Adenoviridae / Q000235:genetics / Q000502:physiology; D017500:Adenovirus E1A Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D050882:CREB-Binding Protein; D018797:Cell Cycle Proteins / Q000235:genetics / Q000502:physiology*; D002455:Cell Division; D002472:Cell Transformation, Viral / Q000235:genetics; D018389:Codon, Nonsense; D016147:Genes, Tumor Suppressor; D051548:Histone Acetyltransferases; D006801:Humans; D019656:Loss of Heterozygosity; D051379:Mice; D008954:Models, Biological; D009363:Neoplasm Proteins / Q000235:genetics / Q000502:physiology; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D011499:Protein Processing, Post-Translational / Q000235:genetics; D017434:Protein Structure, Tertiary; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D014157:Transcription Factors; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor
D000123:Acetyltransferases; D017500:Adenovirus E1A Proteins; D050882:CREB-Binding Protein; D018797:Cell Cycle Proteins; D018389:Codon, Nonsense; D051548:Histone Acetyltransferases; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D050880:p300-CBP Transcription Factors; D000099224:p300-CBP-Associated Factor; C494363:CREBBP protein, human; C494364:Crebbp protein, mouse