Chromosome 13 abnormalities in multiple myeloma are mostly monosomy 13.
Chromosome 13 abnormalities are frequently   observed in multiple myeloma (MM). Several   reports recently demonstrated the strong   prognostic value of these abnormalities,   associated with a short survival. Cytogenetic   studies have shown that most of these   abnormalities are complete monosomies. In order   to define the common minimal deletion, we   analysed a series of 234 patients with MM using   fluorescence in situ hybridization (FISH) with a   panel of five probes mapping along the whole   chromosome 13. A chromosome 13 abnormality   was observed in 98 patients (42%), 90 of whom   (92%) displayed a complete monosomy. In seven   of the eight remaining patients presenting partial   deletions, the three probes specific for the 13q14   region were deleted. Only one patient (1%)   displayed a small deletion of the D13S319 locus.   In conclusion, FISH should be used for the   analysis of chromosome 13 abnormalities, using   probes mapping in the 13q14 region.
Laboratory of Haematology, University Hospital, Nantes, France. havetloiseau@chu-nantes.fr
H
H
Avet-Louseau
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A
Daviet
S
S
Sauner
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R
Bataille
D002882:Chromosomes, Human, Pair 13; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009006:Monosomy; D009101:Multiple Myeloma / Q000235:genetics*