Drug delivery via the blood-brain barrier.
The blood-brain barrier forms a buffer against the systemic circulation. Now drugs administered to the brain are shown to be exported by a transporter to act at peripheral sites.
Edwards
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Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences and the Departments of Neurology and Physiology, UCSF School of Medicine, 513 Parnassus Avenue, San Francisco, California 94143-0435, USA. edwards@itsa.ucsf.edu
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000187:drug effects / Q000378:metabolism; D018528:ATP-Binding Cassette Transporters / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002352:Carrier Proteins / Q000187:drug effects* / Q000378:metabolism; D006801:Humans
D018435:ATP Binding Cassette Transporter, Subfamily B; D018528:ATP-Binding Cassette Transporters; D002352:Carrier Proteins; C095122:multidrug resistance protein 3