An exponential modeling algorithm for protein structure completion by X-ray crystallography.
An exponential modeling algorithm is developed for protein structure completion by X-ray crystallography and tested on experimental data from a 59-residue protein. An initial noisy difference Fourier map of missing residues of up to half of the protein is transformed by the algorithm into one that allows easy identification of the continuous tube of electron density associated with that polypeptide chain. The method incorporates the paradigm of phase hypothesis generation and cross validation within an automated scheme.
Shneerson
V L
VL
Department of Physics, University of Wisconsin-Milwaukee, PO Box 413, Milwaukee, WI 53201, USA.
Wild
D L
DL
Saldin
D K
DK
D000465:Algorithms; D018360:Crystallography, X-Ray; D004546:Elapid Venoms / Q000737:chemistry; D005583:Fourier Analysis; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*
D004546:Elapid Venoms; D011506:Proteins; C020273:dendrotoxin