Totally necrotic choroidal and ciliary body melanomas: associations with prognosis, episcleritis, and scleritis.
OBJECTIVE
To report associations between prognosis, total tumor necrosis, scleritis, and episcleritis in choroidal and ciliary body melanomas.


METHODS
In this retrospective observational histopathologic study, 157 totally necrotic melanomas and 177 melanomas that were not totally necrotic of choroidal and ciliary body were retrieved from the Registry of Ophthalmic Pathology. The eyes were examined for the histologic evidence of inflammatory cells within the sclera and episcleral tissues. Contingency table, Kaplan-Meier, and Cox proportional hazard regression analyses were performed. In the survival analyses, only deaths with metastatic melanoma were considered as events in the statistical analysis.


RESULTS
Among the totally necrotic melanomas, 118 of 157 (75.1%) had both episcleritis and scleritis; two of 157 (1.3%) had scleritis only; 29 of 157 (18.5%) had episcleritis only; and eight of 157 (5.1%) had neither episcleritis nor scleritis. Among the non-necrotic melanomas, 23 of 177 (12.9%) had both episcleritis and scleritis; eight of 177 (4.5%) had scleritis only; 71 of 177 (40.1%) had episcleritis only; and 75 of 177 (42.3%) had neither episcleritis nor scleritis. Cox regression indicated that total necrosis and scleritis were prognostically significant (P <.05) when analyzed univariately but not significant when analyzed multivariately with tumor size.


CONCLUSIONS
Scleritis and episcleritis were statistically significantly associated with total tumor necrosis. There was a higher incidence of episcleritis than scleritis in both the necrotic and non-necrotic tumor types. Associations with patient outcome were identified for necrosis and scleritis. However, these associations were statistically insignificant when the prognostic effect of tumor size was also considered in a multivariate model.
Department of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington, DC, USA
A
A
Moshari
E W
EW
Cheeseman
I W
IW
McLean
D002830:Choroid Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D002924:Ciliary Body / Q000473:pathology*; D006801:Humans; D008545:Melanoma / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D009336:Necrosis; D011379:Prognosis; D012189:Retrospective Studies; D015423:Scleritis / Q000150:complications* / Q000175:diagnosis / Q000401:mortality; D015996:Survival Rate; D014604:Uveal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000401:mortality