Modulation of wound healing after glaucoma surgery.
The healing process after glaucoma filtration is the main determinant of surgical failure and, even more important, the final intraocular pressure. The ability to fully control wound healing may ultimately give us the ability to set the intraocular pressure in the low teens for all patients undergoing glaucoma filtration surgery. The authors review the changes in how to use antimetabolites to improve safety, and many of the exciting new areas of progress, including growth factor neutralization and future molecular therapies to control wound healing.
Wound Healing Research Unit, Department of Pathology, Institute of Ophthalmology and Moorfields Eye Hospital, London, England.
P T
PT
Khaw
L
L
Chang
T T
TT
Wong
A
A
Mead
J T
JT
Daniels
M F
MF
Cordeiro
D000963:Antimetabolites / Q000008:administration & dosage; D017209:Apoptosis / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003228:Conjunctiva / Q000473:pathology; D005109:Extracellular Matrix / Q000187:drug effects / Q000473:pathology; D018463:Filtering Surgery; D005901:Glaucoma / Q000601:surgery*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007429:Intraocular Pressure; D009883:Ophthalmic Solutions; D011184:Postoperative Period; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology
D000963:Antimetabolites; D007166:Immunosuppressive Agents; D009883:Ophthalmic Solutions