[A case of advanced hepatocellular carcinoma with portal invasion resected after treatment by continuous intra-arterial chemotherapy with cisplatin and 5-fluorouracil].
A 67-year-old male diagnosed as having inoperable advanced hepatocellular carcinoma with portal invasion was able to undergo resection after continuous intra-arterial chemotherapy with 5-fluorouracil (5-FU) and cisplatin (CDDP). These were continuously administered for 24 hours at doses of 5-FU of 250 mg and CDDP of 5 mg/day, from day 1 to day 5 in a week, repeated 6 times. In additions to the reductions of the levels of AFP and PIVKA-II from 212.6 ng/ml and 16,100 mAU/ml to 11.8 ng/ml and 12 mAU/ml, respectively, the volume of the tumor and the portal invasion were diminished remarkably. As a result, a left extended hepatectomy could be performed. No sign of recurrence was seen during 16 months of follow-up after the operation. Given the above results, continuous intra-arterial chemotherapy with 5-FU and CDDP therapy may be effective for patients with hepatocellular carcinoma.
Dept. of Surgery, Okayama Red Cross Hospital.
H
H
Matsumoto
M
M
Naitoh
F
F
Hara
S
S
Mitunaga
E
E
Ikeda
S
S
Moriyama
T
T
Tuji
S
S
Furutani
S
S
Nawa
K
K
Ohtuka
Y
Y
Kashiyama
D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage*; D019698:Hepatitis C, Chronic / Q000150:complications; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000628:therapy*; D008297:Male; D009361:Neoplasm Invasiveness; D009360:Neoplastic Cells, Circulating / Q000473:pathology; D011168:Portal System / Q000473:pathology
D002945:Cisplatin; D005472:Fluorouracil