Epstein-Barr virus-associated T cell lymphoproliferative disorder following autologous blood stem cell transplantation for relapsed Hodgkin's disease.
Post-transplant lymphoproliferative disorders (PTLD) of T cell type are a rare complication of solid organ and allogeneic hematopoietic cell transplantation (HCT), and usually are not associated with Epstein-Barr virus (EBV) infection. EBV-associated T cell PTLD has not been reported to occur after autologous HCT. We report an unusual case of T cell lymphoproliferation after autologous blood stem cell transplantation (ABSCT). A patient with relapsed Hodgkin's disease developed abdominal lymphadenopathy followed by atypical CD8+ lymphocytosis in the peripheral blood 30 months following ABSCT. DNA studies of the atypical lymphocytes demonstrated rearrangements of the T cell receptor beta gene and a clonal proliferation of EBV.
Department of Hematology, National Kyushu Cancer Center Hospital, Fukuoka, Japan.
Y
Y
Yufu
M
M
Kimura
R
R
Kawano
Y
Y
Noguchi
H
H
Takatsuki
N
N
Uike
K
K
Ohshima
D002999:Clone Cells / Q000473:pathology / Q000821:virology; D004279:DNA, Viral; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006689:Hodgkin Disease / Q000150:complications / Q000628:therapy*; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000150:complications / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D014182:Transplantation, Autologous / Q000009:adverse effects*
D004279:DNA, Viral