Low cerebral blood flow velocity and risk of white matter hyperintensities.
Cerebral blood flow velocity (CBF-V) measured by transcranial doppler was assessed in 628 elderly individuals who had cerebral magnetic resonance imaging performed as part of a population-based study on vascular aging. Cerebral white matter hyperintensities (WMHs) were associated with low CBF-V, such as the adjusted odds ratios of severe WMHs from highest (referent) to lowest quartile of mean CBF-V were 1.0, 1.7, 3.7, and 4.3 (p = 0.001). Further, CBF-V was found to be a stronger risk factor for WMHs than high blood pressure. These findings suggest that the assessment of CBF-V might be a powerful tool in future studies on WMHs.
INSERM (National Institute for Health and Medical Research) U360, Hôpital Pitié-Salpêtrière, Paris, France. tzourio@chups.jussieu.fr
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Tzourio
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Lévy
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Dufouil
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PJ
Touboul
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Ducimetière
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Alpérovitch
D000368:Aged; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000473:pathology*; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012307:Risk Factors; D017585:Ultrasonography, Doppler, Transcranial