COX-2 inhibitors and the kidney.
Prostaglandins produced by the COX-2 isoform of cyclooxygenase may be important for renal function--and perhaps even more so in diseases that render the kidney highly prostaglandin-dependent. COX-2 inhibitors may thus have much the same renal risks that a standard NSAID does. Several clinical trials have already focused on the new drugs' renal effects.
Perazella
M A
MA
Yale University School of Medicine, New Haven, Conn, USA.
D058186:Acute Kidney Injury / Q000139:chemically induced; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D011453:Prostaglandins / Q000096:biosynthesis / Q000502:physiology; D020033:Protein Isoforms / Q000502:physiology; D011720:Pyrazoles; D013449:Sulfonamides / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D020033:Protein Isoforms; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib