The 2-chlorotrityl resin: a worthy addition to the medicinal chemist's toolbox.
The polystyrene-based 2-chlorotrityl resin was originally used in the synthesis of peptides using an Fmoc-amino acid/carboxyl-linked protocol. While traditionally employed to prepare a number of biologically active peptides, the resin has received increasing attention as a support for the synthesis of pseudopeptide and non-peptide molecules recently. This review focuses on 2-chlorotrityl resin-supported synthesis of small molecules that collectively display a broad range of biological activities.
Discovery Research Chemistry, GlaxoSmithKline, Five Moore Drive, Research Triangle Park, North Carolina, 27709-3398, USA. Wjh35074@glaxowellcom.com
W J
WJ
Hoekstra
D010455:Peptides / Q000138:chemical synthesis*; D011137:Polystyrenes / Q000737:chemistry; D012116:Resins, Plant / Q000737:chemistry*; D014320:Triphenylmethyl Compounds / Q000737:chemistry*
D010455:Peptides; D011137:Polystyrenes; D012116:Resins, Plant; D014320:Triphenylmethyl Compounds; C071065:2-chlorotrityl chloride