[Effect of sodium alpha-ketoglutarate injected after x-ray treatment on the respiration and oxidative phosphorylation of hepatic mitochondria].
It have been found that total X-ray treatment (everyday expose to 1 Roentgen up to achievement of total doses 10, 20 30 Roentgen) inhibits the rate of ADP-stimulated respiration of rat liver mitochondria, decreases its efficiency and makes phosphorylation less couple to respiration. All this effects are present from the first period after treatment till the end of treatment. Intraperitoneal alpha-ketoglutarate injections during treatment decreases the inhibition of respiration and oxidative phosphorylation, increases the efficiency of respiration during the period from 1-st injected till the end of experiment.
I. Franko National University, Ministry of Education, Lviv, Ukraine.
N M
NM
Kurgaliuk
O V
OV
Gorin'
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D019069:Cell Respiration / Q000528:radiation effects*; D007274:Injections, Intraperitoneal; D007656:Ketoglutaric Acids / Q000008:administration & dosage / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000378:metabolism / Q000528:radiation effects*; D010085:Oxidative Phosphorylation / Q000528:radiation effects*; D011837:Radiation-Protective Agents / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D014964:X-Ray Therapy
D007656:Ketoglutaric Acids; D011837:Radiation-Protective Agents; D000244:Adenosine Diphosphate