Postprandial hypertriglyceridemia impairs endothelial function by enhanced oxidant stress.
OBJECTIVE
it appears that hypertriglyceridemia (HTG) is a risk factor of atherosclerosis as demonstrated by recent studies. In this study, we analyzed the effects of acute HTG on endothelial function and oxidative stress, which are important mechanisms in the pathogenesis of atherosclerosis.


RESULTS
in a high fat meal group (n = 11), serum triglycerides and PMA-activated leukocyte O(2)(-)* production were significantly (P < 0.005) increased from 146 +/- 69 mg/dl and 4.09 +/- 0.93 nmol/10(6) cells/min preprandially to 198 +/- 88 mg/dl and 5.49 +/- 1.19 nmol/10(6) cells/min, respectively, 2 h after eating a high-fat meal. The flow-mediated endothelium-dependent brachial artery dilation (FMD; high-resolution ultrasound) was decreased from 13.7 +/- 3.3% preprandially to 8.2 +/- 3.7%, 2 h after eating a high-fat meal (P < 0.005). However, following a low-fat meal (n = 9), there were no significant changes in triglycerides, leukocyte O(2)(-)* production and FMD. Changes of serum triglycerides were correlated negatively (r = -0.650, P < 0.005) with changes of FMD, but were correlated positively (r = 0.798, P < 0.001) with changes of leukocyte O(2)(-)* production, which - in turn - were correlated negatively (r = -0.784, P < 0.001) with changes of FMD in all study subjects (mean age: 56 years, n = 20).


CONCLUSIONS
this study suggests that acute HTG causes endothelial dysfunction via enhanced oxidant stress and this may pave the way for the development of atherosclerosis under chronic conditions.
Department of Internal Medicine, Division of Cardiology, College of Medicine, Konyang University, 685 Gasoowon-dong, Seo-gu, Taejon, South Korea. jhbae@kyuh.co.kr
J H
JH
Bae
E
E
Bassenge
K B
KB
Kim
Y N
YN
Kim
K S
KS
Kim
H J
HJ
Lee
K C
KC
Moon
M S
MS
Lee
K Y
KY
Park
M
M
Schwemmer
D000208:Acute Disease; D000886:Anthropometry; D001161:Arteriosclerosis / Q000209:etiology; D001916:Brachial Artery / Q000648:ultrastructure; D018752:Diet, Fat-Restricted; D004041:Dietary Fats / Q000009:adverse effects; D004435:Eating; D004730:Endothelium, Vascular / Q000378:metabolism / Q000503:physiopathology*; D005260:Female; D018056:Hemorheology; D006801:Humans; D015228:Hypertriglyceridemia / Q000378:metabolism*; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017698:Postmenopause; D016897:Respiratory Burst / Q000187:drug effects; D013481:Superoxides / Q000097:blood; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014664:Vasodilation
D004041:Dietary Fats; D013481:Superoxides; D013755:Tetradecanoylphorbol Acetate