Receptor activity modifying proteins.
Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. A similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current state of knowledge of the mechanisms underlying RAMP function.
Molecular Pharmacology Laboratory, Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia. p.sexton@hfi.unimelb.edu.au
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PM
Sexton
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Albiston
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Morfis
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Tilakaratne
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D019281:Dimerization; D006031:Glycosylation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D018613:Microscopy, Confocal; D008954:Models, Biological; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010455:Peptides; D010641:Phenotype; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D051381:Rats; D058261:Receptor Activity-Modifying Proteins; D018003:Receptors, Calcitonin / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism* / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D010455:Peptides; D058261:Receptor Activity-Modifying Proteins; D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface