[Significance of bcl-2 gene breaking and bcl-2 protein expression in nasopharyngeal carcinoma].
In order to study the relationship between bcl-2 gene and nasopharyngeal carcinoma. The two hot breakpoints of bcl-2 gene and bcl-2 protein expression were examined by in situ hybridization and immunohistochemistry technique in 41 nasopharyngeal carcinoma(NPC) tissues. bcl-2 gene breakpoint were found in 4 cases of NPC(positive rate 9.8%). 34 cases of NPC expressed bcl-2 protein, the positive incidence was 82.9%. No statistically significant differences was found in histological grades. All benign lesions were negative for bcl-2 gene breaking and bcl-2 protein expression. There was no corresponding relation between bcl-2 protein expression and bcl-2 gene breaking. The results implicated that bcl-2 gene breaking may not play an important role in the pathogenesis of NPC. It also suggested that overexpression of bcl-2 protein may involved in carcinogenesis of nasopharyngeal epithelium.
Department of Pathology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282.
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D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000235:genetics; D019457:Chromosome Breakage; D019254:Genes, bcl-2; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000737:chemistry / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis*
D019253:Proto-Oncogene Proteins c-bcl-2