Induction of the monocytic differentiation of myeloid leukaemia cells by cotylenin A, a plant growth regulator.
Regulators that play an important role in the differentiation and development of plants or invertebrates may also affect the differentiation of human leukaemia cells through a common signal transduction system, and might be clinically useful for treating acute myeloid leukaemia. Cotylenin A has been isolated as a plant growth regulator. We examined the effects of cotylenin A on the differentiation of several myelogenous leukaemia cells, and found that cotylenin A is a potent and novel inducer of the monocytic differentiation of human myeloid leukaemia cells. Cotylenin A induced the functional and morphological differentiation of myeloblastic and promyelocytic leukaemia cells, but did not effectively induce the differentiation of monocytoid leukaemia cells. Cotylenin A-induced differentiation was not affected by several inhibitors of signal transduction, suggesting that this inducer exhibits a unique mode of action.
Yamamoto-Yamaguchi
Y
Y
Saitama Cancer Centre Research Institute, Ina, Kita-adachi, Saitama 362-0806, Japan.
Yamada
K
K
Ishii
Y
Y
Asahi
K I
KI
Tomoyasu
S
S
Honma
Y
Y
D000730:Androstadienes / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D015415:Biomarkers / Q000032:analysis; D002454:Cell Differentiation / Q000187:drug effects; D004224:Diterpenes / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005419:Flavonoids / Q000494:pharmacology; D018922:HL-60 Cells; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007951:Leukemia, Myeloid / Q000276:immunology*; D018950:Lipopolysaccharide Receptors / Q000032:analysis; D008301:Maleimides / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D009281:Naphthalenes / Q000494:pharmacology; D010937:Plant Growth Regulators / Q000737:chemistry / Q000494:pharmacology*; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D020298:U937 Cells; D010566:Virulence Factors, Bordetella / Q000494:pharmacology; D000077191:Wortmannin
D000730:Androstadienes; D000970:Antineoplastic Agents; D015415:Biomarkers; D004224:Diterpenes; D004791:Enzyme Inhibitors; D005419:Flavonoids; D007211:Indoles; D018950:Lipopolysaccharide Receptors; D008301:Maleimides; D009281:Naphthalenes; D010937:Plant Growth Regulators; D014409:Tumor Necrosis Factor-alpha; D010566:Virulence Factors, Bordetella; C423222:cotylenin A; D014212:Tretinoin; D007371:Interferon-gamma; C058819:calphostin C; C070515:bisindolylmaleimide I; C093973:2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one; D000077191:Wortmannin