Acylation of indole under Friedel-Crafts conditions-an improved method to obtain 3-acylindoles regioselectively.
[reaction: see text]. The reaction of unsubstituted indole with different acylating agents such as acid chlorides, anhydrides, nitriles, and amino acid derivatives in the presence of Lewis acid is reported.
Ottoni
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Instituto de Química, Universidade de Brasília, C. P. 04478, CEP 70910-970, Brasília-DF, Brasil.
Neder
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Dias
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D000215:Acylation; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis; D012997:Solvents / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
D017607:Aluminum Compounds; D002712:Chlorides; D007211:Indoles; D011108:Polymers; D012997:Solvents; D017971:Tin Compounds; D000077410:Aluminum Chloride; C041694:stannic chloride; C030374:indole; C025096:titanium tetrachloride; D014025:Titanium