Synthetic analogues of SB-219383. Novel C-glycosyl peptides as inhibitors of tyrosyl tRNA synthetase.
Novel inhibitors of bacterial tyrosyl tRNA synthetase have been synthesised in which the cyclic hydroxylamine moiety of SB-219383 is replaced by C-pyranosyl derivatives. Potent and selective inhibition of bacterial tyrosyl tRNA synthetase was obtained.
GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, USA. pam_brown-1@sbphrd.com
P
P
Brown
D S
DS
Eggleston
R C
RC
Haltiwanger
R L
RL
Jarvest
L
L
Mensah
P J
PJ
O'Hanlon
A J
AJ
Pope
D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000737:chemistry* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000737:chemistry* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology; D008958:Models, Molecular; D015394:Molecular Structure; D011714:Pyrans / Q000737:chemistry*; D013211:Staphylococcus aureus / Q000201:enzymology / Q000378:metabolism; D014448:Tyrosine-tRNA Ligase / Q000037:antagonists & inhibitors*
D001426:Bacterial Proteins; D019086:Bridged Bicyclo Compounds, Heterocyclic; D004791:Enzyme Inhibitors; D005663:Furans; D011714:Pyrans; C410784:SB 219383; D014448:Tyrosine-tRNA Ligase