DNA helicase deficiencies associated with cancer predisposition and premature ageing disorders.
Deficiency in a helicase of the RecQ family is found in at least three human genetic disorders associated with cancer predisposition and/or premature ageing. The RecQ helicases encoded by the BLM, WRN and RECQ4 genes are defective in Bloom's, Werner's and Rothmund-Thomson syndromes, respectively. Cells derived from individuals with these disorders in each case show inherent genomic instability. Recent studies have demonstrated direct interactions between these RecQ helicases and human nuclear proteins required for several aspects of chromosome maintenance, including p53, BRCA1, topoisomerase III, replication protein A and DNA polymerase delta. Here, we review this network of protein interactions, and the clues that they present regarding the potential roles of RecQ family members in DNA repair, replication and/or recombination pathways.
Imperial Cancer Research Fund Laboratories, University of Oxford, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Oxford OX3 9DS, UK.
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Mohaghegh
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Hickson
D000251:Adenosine Triphosphatases / Q000172:deficiency* / Q000235:genetics*; D000375:Aging; D001816:Bloom Syndrome / Q000235:genetics; D002467:Cell Nucleus / Q000378:metabolism; D004265:DNA Helicases / Q000172:deficiency* / Q000235:genetics*; D004260:DNA Repair; D004261:DNA Replication; D020022:Genetic Predisposition to Disease; D006801:Humans; D005810:Multigene Family; D009369:Neoplasms / Q000201:enzymology* / Q000235:genetics*; D011485:Protein Binding; D053484:RecQ Helicases; D011995:Recombination, Genetic; D011038:Rothmund-Thomson Syndrome / Q000235:genetics; D014898:Werner Syndrome / Q000235:genetics
D000251:Adenosine Triphosphatases; C506725:RECQL protein, human; D004265:DNA Helicases; D053484:RecQ Helicases