New cyclic depsipeptide antibiotics, clavariopsins A and B, produced by an aquatic hyphomycetes, Clavariopsis aquatica. 1. Taxonomy, fermentation, isolation, and biological properties.
Clavariopsins were isolated from the fermentation broth of Clavariopsis aquatica AJ 117363. Clavariopsins are cyclic depsipeptide antibiotics with the molecular weight of 1,153 and 1,139. Clavariopsins showed in vitro antifungal activity against not only Aspergillus fumigatus but also, although to a lesser extent, A. niger and Candida albicans.
Pharmaceutical Research Laboratories, Ajinomoto Co, Inc. kenichi_kaida@ajinomoto.com
K
K
Kaida
R
R
Fudou
T
T
Kameyama
K
K
Tubaki
Y
Y
Suzuki
M
M
Ojika
Y
Y
Sakagami
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D047630:Depsipeptides; D005285:Fermentation; D051379:Mice; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000145:classification / Q000378:metabolism*; D015394:Molecular Structure; D010456:Peptides, Cyclic
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D047630:Depsipeptides; D010456:Peptides, Cyclic; C423647:clavariopsin A; C423648:clavariopsin B