Improved selectivity of double quantum coherence filtering for the detection of glutathione in the human brain in vivo.
An improved double quantum coherence (DQC) filter for the selective in vivo detection of glutathione (GSH) in the human brain at 1.5 Tesla is presented. The goal was to minimize contamination of the DQC-filtered GSH signal at 2.9 ppm with contributions arising from GABA. The modification consists of tailoring the frequency response of the read pulse, which converts DQC into anti-phase single quantum coherence in such a way that the GABA beta and gamma resonances at 3.0 and 1.9 ppm, respectively, remain unaffected. An implementation incorporating a Dante pulse train is used for in vitro tests as well as for in vivo applications. Magn Reson Med 45:708-710, 2001.
Institute of Biomedical Engineering and Medical Informatics, University of Zurich and Swiss Federal Institute of Technology Zurich, Zurich, Switzerland.
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Trabesinger
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Boesiger
D001923:Brain Chemistry; D005978:Glutathione / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D005680:gamma-Aminobutyric Acid; D005978:Glutathione