Formulation, characterization, and in vitro release of glyburide from proliposomal beads.
The objective of our study was to formulate and evaluate proliposomes in the form of enteric-coated beads using glyburide as a model drug. The beads were enteric coated with Eudragit L-100 by a fluidized bed coating process using triethyl citrate as plasticizer. Content uniformity of glyburide was estimated using HPLC analysis of beads dissolved in methanol. These proliposomal beads formed liposomes on disintegration in phosphate buffered saline (pH 7.4), which was confirmed by transmission electron microscopy. The dissolution study of enteric-coated beads exhibited enhanced dissolution compared with pure drug and a marketed product. Liposomes can be successfully prepared for oral administration in the form of enteric-coated beads that may offer a stable system to produce liposomes for oral administration.
Kumar
R
R
Department of Pharmacal Sciences, School of Pharmacy, Auburn University, Alabama, USA.
Gupta
R B
RB
Betageri
G V
GV
D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D016503:Drug Delivery Systems; D005905:Glyburide / Q000493:pharmacokinetics*; D007004:Hypoglycemic Agents / Q000493:pharmacokinetics*; D066298:In Vitro Techniques; D008081:Liposomes; D008854:Microscopy, Electron; D008863:Microspheres
D007004:Hypoglycemic Agents; D008081:Liposomes; D005905:Glyburide