Bypassing IgE and targeting T cells for specific immunotherapy of allergy.
Specific immunotherapy (SIT) is a common treatment for allergic diseases. Despite its usage in clinical practice for nearly a century, more-rational and safer allergen preparations are required. Here, the underlying mechanisms and principles of allergen modification for the future use of SIT in the treatment of allergy are discussed.
Akdis
C A
CA
Swiss Institute of Allergy and Asthma Research (SIAF), CH-7270 Davos, Switzerland. akdisac@siaf.unizh.ch
Blaser
K
K
D000485:Allergens / Q000276:immunology*; D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D007073:Immunoglobulin E / Q000276:immunology*; D007167:Immunotherapy; D013601:T-Lymphocytes / Q000276:immunology*
D000485:Allergens; D007073:Immunoglobulin E