The first total synthesis of +-ratjadone.
The first total synthesis of ratjadone was achieved using a highly convergent approach joining three subunits together with a Wittig olefination and a selective Heck reaction as the pivotal steps. Besides establishing a robust and reliable route for the synthesis of this orphan ligand, the configuration of unknown stereocenters could also be determined. This synthesis not only provides an additional access to a biologically important compound but also enables the synthesis of structural analogues for biological target identification.
Institut für Organische Chemie der Universität Hannover, Schneiderberg 1B, D-30167 Hannover, Germany.
U
U
Bhatt
M
M
Christmann
M
M
Quitschalle
E
E
Claus
M
M
Kalesse
D008956:Models, Chemical; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry*; D011753:Pyrones / Q000138:chemical synthesis* / Q000737:chemistry; D013057:Spectrum Analysis
D011753:Pyrones; C429103:ratjadone