Insights into peptide and protein function: a convergent approach.
From viruses to multicellular organisms, life is inseparable from the genetic instructions aimed at regulating its maintenance, division, multiplication, differentiation and death (apoptosis). Over the past 15 years, structural studies have begun to resolve the complex reactions involved in these fundamental processes in biology. The three-dimensional representations of the complexes formed with peptides and/or proteins have allowed interpretation of the biochemical data and formulation of novel hypotheses about the control and execution of these processes. Moreover, they have opened the way to rational approaches for designing compounds able to interfere with these crucial events in normal or pathological conditions. Various results obtained in our laboratory in these fields are briefly summarized in this review.
Département de Pharmacochimie Moléculaire et Structurale, INSERM U266, CNRS UMR8600, UFR des Sciences Pharmaceutiques et Biologiques, Paris, France. roques@pharmacie.univ-paris5.fr
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D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D002318:Cardiovascular Diseases / Q000188:drug therapy; D010450:Endopeptidases / Q000737:chemistry; D006168:Guinea Pigs; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008024:Ligands; D008956:Models, Chemical; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000737:chemistry; D010146:Pain / Q000188:drug therapy; D010455:Peptides / Q000737:chemistry* / Q000502:physiology*; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000502:physiology*; D051381:Rats
D007166:Immunosuppressive Agents; D008024:Ligands; D009479:Neuropeptides; D010455:Peptides; D011506:Proteins; D010450:Endopeptidases