Comparison of subretinal fluid levels of two 0.3% ciprofloxacin-containing eye drops.
OBJECTIVE
Two ophthalmic solutions of 0.3% ciprofloxacin eye drops are available in Turkey: Ciloxan and Siprogut. A previous study by the same authors was the first to report vitreous penetration of ciprofloxacin-containing eye drops. The aim of the present study was to compare the levels of drug found in the subretinal fluid by the two products following local administration.


METHODS
Forty-three patients undergoing conventional retinal detachment surgery received either Ciloxan (22 patients) or Siprogut (21 patients). Beginning 6 h before surgery, two drops of solution were instilled onto the operative eye every 30 min for the first 3 h and then hourly for the next 3 h. Subretinal fluid samples were collected 30 min after administration of the last dose and were assayed for ciprofloxacin levels using a method involving high-performance liquid chromatography with fluorometric detection.


RESULTS
The minimum and maximum subretinal fluid concentrations measured were 0.11 microg/mL and 0.65 microg/mL, respectively, with Ciloxan, and 0.08 microg/mL and 0.62 microg/mL, respectively wth Siprogut. There was no statistical difference between the subretinal fluid ciprofloxacin levels of the two products. The subretinal fluid drug evels attained by both products were below the minimum inhibitory concentrations of common ocular pathogens.


CONCLUSIONS
Ciloxan and Siprogut can penetrate subretinal fluid. The ocular bioavailability of ciprofloxacin after local administration is equivalent for both pharmaceutical products.
Department of Vitreoretinal Surgery, SSK Ankara Eye Hospital, Turkey. ocekic@usa.net
O
O
Cekiç
C
C
Batman
U
U
Yaşar
Y
Y
Totan
N E
NE
Başci
A
A
Bozkurt
O
O
Zilelioglu
S O
SO
Kayaalp
D000042:Absorption; D000287:Administration, Topical; D000368:Aged; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D001682:Biological Availability; D001826:Body Fluids / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D002939:Ciprofloxacin / Q000493:pharmacokinetics*; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D012160:Retina / Q000378:metabolism*; D012163:Retinal Detachment / Q000601:surgery; D012591:Scleral Buckling
D000890:Anti-Infective Agents; D009883:Ophthalmic Solutions; D002939:Ciprofloxacin