[Cerebrocrast correction of reparative osteogenesis on the background of chronic stress].
Protective action of cerebrokrast--a derivative from 1,4-dihydropyridine--on the processes of reparative osteogenesis in rats in case of combined action of chronic emotional-pain stress and trauma of mandibular was determined. It is stipulated by a antioxidant properties of cerebrokrast, as well as its stabilizing influence on glycoproteins and calcium homeostasis. The redeived data extend the idea about general-metabolic action of the investigated nootrop at the level of the whole organism and testify worthwhile of its use for prophylaxis of extreme conditions.
Ukrainian Medical Dental Academy, Ukrainian Health Protection Ministry, Poltava, Ukraine.
T O
TO
Dev'iatkina
L I
LI
Voloshina
V Ie
VIe
Klusha
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D002908:Chronic Disease; D004095:Dihydropyridines / Q000627:therapeutic use*; D006023:Glycoproteins / Q000378:metabolism; D008338:Mandibular Injuries / Q000188:drug therapy*; D010012:Osteogenesis / Q000187:drug effects*; D018384:Oxidative Stress / Q000502:physiology*; D010146:Pain / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D004095:Dihydropyridines; D006023:Glycoproteins; C073838:2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine; D002118:Calcium