Antigen processing by the proteasome.
The proteasome is an essential part of our immune surveillance mechanisms: by generating peptides from intracellular antigens it provides peptides that are then 'presented' to T cells. But proteasomes--the waste-disposal units of the cell--typically do not generate peptides for antigen presentation with high efficiency. How, then, does the proteasome adapt to serve the immune system well?
Kloetzel
P M
PM
Institut für Biochemie, Medical Faculty, Charité, Humboldt University, Monbijoustrasse 2, 10117 Berlin, Germany. p-m.kloetzel@charite.de
D017951:Antigen Presentation; D000941:Antigens / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D008958:Models, Molecular; D009097:Multienzyme Complexes / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D014452:Ubiquitins / Q000737:chemistry
D000941:Antigens; D009097:Multienzyme Complexes; D014452:Ubiquitins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex