[Nasal mucosa and systemic repercussion of the topical and prolonged use of budesonide in patients with perennial allergic rhinitis].
In a prospective study, measurement of a 9.00 a.m. basal serum cortisol and biopsies of the inferior turbinate mucosa were taken from 40 patients using topical nasal corticosteroid (Budesonide) continuously for month or years. No systemic adverse effects and no histopathological changes of significance were found. These findings do no suggest that topically corticosteroids are harmful to the nasal mucosa and no produce systemic effects.
López Aguado
D
D
Cátedra de ORL, Facultad de Medicina, Universidad de La Laguna, Tenerife.
López Campos
D
D
García González
L A
LA
Pérez Piñero
B
B
Campos Bañales
M E
ME
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D019819:Budesonide / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects* / Q000473:pathology; D011446:Prospective Studies; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D019819:Budesonide; D006854:Hydrocortisone