Lignans from Kadsura angustifolia.
A new dibenzocyclooctadiene lignan named angustifolin D (1) together with four known lignans: kadsulignan L (2), kadsulignan N (3), schisantherin P (4) and meso-dihydroguaiaretic acid (5) were isolated from the stems of Kadsura angustifolia. Their structures and stereochemistries were elucidated by spectral studies. Compounds 2 and 5 showed moderate platelet-activating factor (PAF) antagonistic activities with IC50 values of 2.6 x 10(-5) and 4.1 x 10(-5) M, respectively.
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China.
Y G
YG
Chen
G W
GW
Qin
Y Y
YY
Xie
K F
KF
Cheng
Z W
ZW
Lin
H D
HD
Sun
Y H
YH
Kang
B H
BH
Han
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019684:Magnoliopsida / Q000737:chemistry*; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000378:metabolism; D011817:Rabbits; D013057:Spectrum Analysis
D017705:Lignans; D010972:Platelet Activating Factor