The influence of thrombus components in mediating bacterial adhesion to biomaterials.
Thrombosis and infection represent the two largest limiting factors determining the long term success of implanted biomaterials. Infections associated with biomaterials are difficult to treat, and appear to evade the host defense systems. Mechanisms relating infection to thrombosis are described. Investigations into the role of receptors in mediating adhesion to thrombi are also discussed, in addition to strategies to reduce bacterial adhesion to biomaterial surfaces.
Lamba
N M
NM
Department of Chemical Engineering, University of Delaware, Newark 19716, USA.
Baumgartner
J N
JN
Cooper
S L
SL
D001422:Bacterial Adhesion / Q000187:drug effects*; D001672:Biocompatible Materials / Q000009:adverse effects / Q000378:metabolism* / Q000494:pharmacology; D001779:Blood Coagulation Factors / Q000494:pharmacology; D003029:Coagulants / Q000494:pharmacology*; D006801:Humans; D013927:Thrombosis / Q000150:complications
D001672:Biocompatible Materials; D001779:Blood Coagulation Factors; D003029:Coagulants