Effects of ligustrazine, tanshinone II A, ubiquinone, and idebenone on mouse water maze performance.
OBJECTIVE
To observe the effects of four drugs, ligustrazine (Lig), tanshinone II A (Tan), ubiquinone (Ubi) and idebenone (Ide), on learning and memory of mouse.


METHODS
Mouse water maze was used to evaluate nootropic effect.


RESULTS
In comparison with the defective model (only scopolamine 3 mg.kg-1, Tan 20 mg.kg-1, ig) shortened the escape latency dramatically from (36 +/- 19) s to (11 +/- 5) s (P < 0.01) and reduced errors from 7 +/- 5 to 1.5 +/- 1.3 (P < 0.05). Ubi 20 mg.kg-1 ig decreased the escape latency from (37 +/- 18) s to (17 +/- 12) s and errors from 8 +/- 5 to 2.1 +/- 2.7 (P < 0.01). Ide 120 mg.kg-1 (ig) reduced the errors from 8 +/- 6 to 3.4 +/- 2.9 (P < 0.05), but had no remarkable effect on the escape latency. Lig did not exhibit marked effect on the deficit.


CONCLUSIONS
Tan, Ubi, and Ide improved scopolamine-caused spatial performance defects in mouse.
School of Biopharmaceutics, China Pharmaceutical University, Nanjing 210009, China. xjliu@fudan.edu.cn
X J
XJ
Liu
W T
WT
Wu
D045784:Abietanes; D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology; D016227:Benzoquinones / Q000494:pharmacology*; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D051379:Mice; D010616:Phenanthrenes / Q000494:pharmacology*; D011719:Pyrazines / Q000494:pharmacology*; D014451:Ubiquinone / Q000494:pharmacology* / Q000031:analogs & derivatives
D045784:Abietanes; D000925:Anticoagulants; D016227:Benzoquinones; D005343:Fibrinolytic Agents; D010616:Phenanthrenes; D011719:Pyrazines; C021751:tanshinone; D014451:Ubiquinone; C036619:idebenone; C017953:tetramethylpyrazine