Preoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer.
BACKGROUND
To identify prognostic factors in stage III and IV endometrial cancer with special attention to pretreatment platelet count.


METHODS
59 patients with FIGO stage III or IV disease operated on between 1983 and 1993 were analyzed. Patients with preoperative thrombocytosis were compared with those without thrombocytosis. Prognostic factors were analyzed with a Cox proportional hazard model.


RESULTS
With the exception of age, there were no significant differences between patients with or without thrombocytosis. At multivariate analysis, five-year disease-free survival was influenced significantly by FIGO stage (stage III vs stage IV; p = 0.009), thrombocytosis (p = 0.02) and cervical involvement (p = 0.024). Similarly, overall five-year survival was significantly influenced by stage (p < 0.001), cervical involvement (p = 0.005) and thrombocytosis (p = 0.01). Age, histology, grade, myometrial invasion, lymph-vascular space involvement or spread to adnexae were not significantly associated with survival.


CONCLUSIONS
Thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer.
Department of Obstetrics and Gynecology, University of Graz, Auenbruggerplatz 14, Graz, A-8036, Austria. scholzhs@kfunigraz.ac.at
H S
HS
Scholz
E
E
Petru
F
F
Gücer
J
J
Haas
K
K
Tamussino
R
R
Winter
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D016889:Endometrial Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010976:Platelet Count; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D013922:Thrombocytosis / Q000150:complications* / Q000175:diagnosis; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000097:blood / Q000401:mortality / Q000473:pathology