Successful combination chemotherapy (vincristine, procarbazine, etoposide, and prednisolone) in the treatment of inoperable, radioresistant low grade astrocytoma: a case report.
A case of successful combination chemotherapy using vincristine, procarbazine, VP-16 and prednisolone to treat an inoperable low grade astrocytoma is presented. This patient, whose tumor was also resistant to radiotherapy, had well controlled symptoms after the initiation of chemotherapy. A brain CT scan demonstrated disappearance of the tumor mass after eight courses of a combination chemotherapy regimen. She is at present symptom-free 80 months after diagnosis. This result suggests that combination chemotherapy may offer treatment modalities for low grade astrocytoma.
Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
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Maipang MVasiknanonte
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Janjindamai SHirunpat
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001254:Astrocytoma / Q000188:drug therapy* / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D002648:Child; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D011344:Procarbazine; D014750:Vincristine; D005047:Etoposide; D011239:Prednisolone