Kinetics of systemic ruthenium in human blood using a stable tracer.
The biokinetics of ruthenium after oral and intravenous administration has been investigated in two human subjects using the stable isotope 101Ru as a tracer. Tracer concentrations in blood plasma have been determined using activation analysis with protons. The results presented here prove that the stable tracer technique is a valuable tool for obtaining relevant information about the biokinetics of ruthenium in humans. From these pilot studies, it may be argued that the clearance of systemic ruthenium from plasma is significantly slower than the predictions of the biokinetic model currently recommended by the International Commission on Radiological Protection (ICRP). The experimental data for the orally administered tracer, which reflect the gastrointestinal absorption process, differ from the curve derived from the ICRP model, suggesting that the uptake into the systemic circulation may be lower than predicted. On the basis of these preliminary data, investigations on a larger number of subjects with improvements in the experimental design are scheduled.
Università degli Studi di Milano, Dipartimento di Fisica, Milano, Italy.
I
I
Veronese
A
A
Giussani
M C
MC
Cantone
D
D
de Bartolo
P
P
Roth
E
E
Werner
D000284:Administration, Oral; D006801:Humans; D007275:Injections, Intravenous; D007554:Isotopes; D008297:Male; D008875:Middle Aged; D012428:Ruthenium / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D012429:Ruthenium Radioisotopes / Q000493:pharmacokinetics
D007554:Isotopes; D012429:Ruthenium Radioisotopes; D012428:Ruthenium