Enantio- and diastereocontrolled synthesis of (-)-iridolactone and (+)-pedicularis-lactone.
[structure: see text]. Two iridoid lactones, (-)-iridolactone and (+)-pedicularis-lactone, have been synthesized in an enantio- and diastereocontrolled manner starting from a tricyclic chiral building block serving as a synthetic equivalent of chiral 3-(hydroxymethyl)cyclopenta-2,4-dien-1-ol.
Tanaka
H
H
Pharmaceutical Institute, Tohoku University, Aobayama, Sendai 980-8578, Japan.
Kamikubo
T
T
Yoshida
N
N
Sakagami
H
H
Taniguchi
T
T
Ogasawara
K
K
D001208:Asia; D007202:Indicators and Reagents; D039823:Iridoids; D007783:Lactones / Q000138:chemical synthesis*; D010946:Plants, Medicinal / Q000737:chemistry*; D013237:Stereoisomerism
D007202:Indicators and Reagents; D039823:Iridoids; D007783:Lactones; C426963:iridolactone; C426964:pedicularis-lactone