Suture materials and local recurrence in colorectal cancer: an experimental study.
OBJECTIVE
To investigate the carcinogenic role of suture materials in an experimental model in rats.


METHODS
Laboratory, experimental study.


METHODS
University hospital, Spain.


METHODS
125 Sprague-Dawley rats in 5 groups of 25 each.


METHODS
3 Different suture materials (silk, polydioxanone, and titanium staples) were implanted in a region of the colon in 75 rats divided into three groups of 25. Another 25 animals were injured by puncture only in the same region, and a further 25 rats were not operated on (controls). Injections of 1-2,dimethylhydrazine were then given for 26 weeks.


METHODS
Number of rats in each group who had tumours in the region of interest, and level of infiltration of the tumours in each group.


RESULTS
There were no differences between the injured and control rats in the number of tumours in the study zone. All groups in which suture material had been inserted had tumours in this zone. Titanium was more carcinogenic than either silk or polydioxanone. The tumours associated with titanium were the most infiltrating.


CONCLUSIONS
We recommend the use of absorbable sutures, with a careful follow-up of patients in whom titanium staples have been used.
Nomdedeu-Guinot
J
J
Department of General Surgery, Hospital General de Castellón, Spain.
Giber-Gerez
J
J
Reig
I C
IC
Sanchís
J L
JL
Planelles
R C
RC
Del Castillo
J R
JR
D000818:Animals; D002273:Carcinogens / Q000009:adverse effects* / Q000494:pharmacology; D016009:Chi-Square Distribution; D003106:Colon / Q000473:pathology* / Q000601:surgery*; D015179:Colorectal Neoplasms / Q000209:etiology*; D004195:Disease Models, Animal; D019476:Insect Proteins / Q000009:adverse effects; D008297:Male; D008422:Materials Testing; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D016687:Polydioxanone / Q000009:adverse effects; D011336:Probability; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D018570:Risk Assessment; D047011:Silk; D013536:Suture Techniques; D013537:Sutures / Q000009:adverse effects*; D014025:Titanium / Q000009:adverse effects
D002273:Carcinogens; D019476:Insect Proteins; D047011:Silk; D016687:Polydioxanone; D014025:Titanium