Responsive polymeric delivery systems.
This paper discusses the state of the art in a relatively new approach in the field of controlled drug delivery-responsive polymeric drug delivery systems. Such systems are capable of adjusting drug release rates in response to a physiological need. The fundamental principles of externally and self-regulated delivery systems are examined. Special attention is paid to specific clinical settings such as diabetes, presenting the advantages and disadvantages of different approaches.
Kost
J
J
Department of Chemical Engineering, Ben-Gurion University of the Negev, P.O. Box 653, 84105, Beer-Sheva, Israel. kost@bgumail.bgu.ac.il
Langer
R
R
D000818:Animals; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D006801:Humans; D011108:Polymers / Q000737:chemistry*
D005079:Excipients; D011108:Polymers