Ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium.
We studied ultrastructure of nuclear compartment in cardiomyocytes during regenerative and plastic insufficiency of the myocardium induced by anthracycline antibiotic daunomycin. A peculiarity of ultrastructural organization of cardiomyocyte nuclei under these conditions is almost complete disappearance of the heterochromatin lumps. The earliest changes in nucleoli under conditions of disturbed DNA-dependent RNA synthesis are segregation of the granular and fibrillar nucleolonema components. Deep alterations in the nucleoli manifested by fragmentation and annulation correlate with pronounced changes in cardiomyocytes ultrastructure, intensive lysis of the myofilaments, reduction of the organelles, and enhanced autophagocytosis.
Laboratory of General Pathological Anatomy, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk. pathol@cyber.nsk.ma.ru
L M
LM
Nepomnyashchikh
E L
EL
Lushnikova
D E
DE
Semenov
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure*; D003630:Daunorubicin / Q000633:toxicity; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration
D000903:Antibiotics, Antineoplastic; D003630:Daunorubicin