HLA-A*01-restricted cytotoxic T-lymphocyte epitope from the Plasmodium falciparum circumsporozoite protein.
Here, we report the identification of a novel CD8+ cytotoxic T-lymphocyte epitope on the Plasmodium falciparum circumsporozoite protein (3D7; amino acids 310 to 319 [EPSDKHIKEY]) that is restricted by HLA-A*01 and is recognized by human volunteers immunized with irradiated P. falciparum sporozoites. HLA-A*01 is the second most common HLA allele among Caucasians.
Kumar
A
A
Malaria Program, Naval Medical Research Center, Silver Spring, Maryland 20910-7500, USA. kumara@nmrc.navy.mil
Kumar
S
S
Le
T P
TP
Southwood
S
S
Sidney
J
J
Cohen
J
J
Sette
A
A
Hoffman
S L
SL
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D018984:Epitopes, T-Lymphocyte; D015234:HLA-A Antigens / Q000235:genetics*; D006801:Humans; D007114:Immunization; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology*; D010963:Plasmodium falciparum / Q000276:immunology*; D015800:Protozoan Proteins / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D015234:HLA-A Antigens; D010446:Peptide Fragments; D015800:Protozoan Proteins; C041595:circumsporozoite protein, Protozoan