[Changes in distortion product otoacoustic emissions and hair cells after noise exposure in guinea pigs].
In order to observe the changes in distortion product otoacoustic emissions (DPOAE) and hair cells after noise exposure, sixteen healthy guinea pigs were used. The animals were divided into 3 groups. Group 1 was normal animals. Group 2 and 3 were animal right and 7 days after exposed to 115 dB SPL simulated submarine engine room noise for 4 hours, respectively. The DPOAE audiogram and I/O function were measured before and after exposure. The changes of hair cells were observed by light microscope and scanning electron microscope. The amplitudes of DPOAE disappeared right after noise exposure(P < 0.01) and recovered to normal at 7 days after exposure (P > 0.05). The light microscopy and scanning electron microscopy showed the stereocilia of the outer hair cells were disarrangement and some disappeared at 2,3,4 kHz regions of the cochlea. The results indicated that the normal outer cells can regulate and compensate the function of some damaged outer hair cells which result in a normal DPOAE in mild damaged cochlea.
Department of Otolaryngology, Navy General Hospital, Beijing 100037.
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D000818:Animals; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000648:ultrastructure*; D009622:Noise / Q000009:adverse effects; D017084:Otoacoustic Emissions, Spontaneous; D011897:Random Allocation