Aerosolized iloprost for severe pulmonary hypertension as a bridge to heart transplantation.
Preexisting pulmonary hypertension in pediatric patients is associated with poor outcome after cardiac transplantation because of donor right ventricular dysfunction. To avoid a combined heart-lung transplantation in a 17-year-old patient, we used an intensified pretreatment with intravenous prostacyclin and dobutamine combined with an inhalative therapy with the aerosolized prostacyclin-analog Iloprost. With this regimen, the patient was hemodynamically stabilized for the waiting period of 21 days after which an uneventful cardiac transplantation was performed.
Department of Thoracic, Medical School Hannover, Germany. th.wittwer-md@t-online.de
T
T
Wittwer
K
K
Pethig
M
M
Strüber
M
M
Hoeper
W
W
Harringer
A
A
Haverich
U
U
Franke
T
T
Wahlers
D000293:Adolescent; D000336:Aerosols; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D016027:Heart Transplantation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D016285:Iloprost / Q000008:administration & dosage*; D008297:Male; D011300:Preoperative Care; D012720:Severity of Illness Index
D000336:Aerosols; D002317:Cardiovascular Agents; D016285:Iloprost