Soy protein hydrolyzate with bound phospholipids reduces serum cholesterol levels in hypercholesterolemic adult male volunteers.
This study was done to evaluate the effects of soy protein hydrolyzate with bound phospholipids (c-SPHP), on the serum cholesterol levels in hypercholesterolemic subjects over a three-month period. Subjects were Taiwanese adult male volunteers whose serum total cholesterol levels were above 220 mg/dl. Twenty-one subjects were divided into three groups randomly, and each group was given c-SPHP zero, 3, or 6 g per day. Test diets were orally administered in a powdered drink form that contained c-SPHP or casein hydrolyzate (placebo). The subjects were given the test diet four times daily. The study consisted of a two-week pre-feeding period, a three-month feeding period, followed by a two-week post-feeding period. After 3 months of c-SPHP administration, 3 g per day, serum total cholesterol decreased significantly from the initial level (15.0%, p<0.01) and compared with the placebo group (p<0.05). Furthermore, LDL-cholesterol decreased significantly (27.7%, p<0.01) and the LDL/HDL ratio also decreased significantly (47.4%, p<0.01) from the initial levels. These effects of c-SPHP were dose-dependent. This study suggests that c-SPHP has remarkable improving effects on the serum cholesterol levels in hypercholesterolemic subjects.
Health Care Products Department, Kyowa Hakko Kogyo Co., Ltd., Tokyo, Japan. goro.hori@kyowa.co.jp
G
G
Hori
M F
MF
Wang
Y C
YC
Chan
T
T
Komatsu
Y
Y
Wong
T H
TH
Chen
K
K
Yamamoto
S
S
Nagaoka
S
S
Yamamoto
D000328:Adult; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004032:Diet; D006801:Humans; D006937:Hypercholesterolemia / Q000178:diet therapy*; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000737:chemistry / Q000378:metabolism; D008297:Male; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism*; D030262:Soybean Proteins / Q000008:administration & dosage* / Q000737:chemistry* / Q000378:metabolism
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D000960:Hypolipidemic Agents; D010743:Phospholipids; D030262:Soybean Proteins; D002784:Cholesterol