Effects of the angiotensin converting enzyme inhibitor benazepril in cats with induced renal insufficiency.
OBJECTIVE
To determine effects of the angiotensin converting enzyme inhibitor benazepril in cats with induced renal insufficiency.


METHODS
32 cats.


METHODS
Renal mass was surgically reduced, and cats were assigned to 1 of 4 eight-cat groups. Group 1 received placebo, whereas groups 2, 3, and 4 received benazepril hydrochloride orally once daily for approximately 6.5 months at the following doses: group 2, 0.25 to 0.50 mg/kg of body weight; group 3, 0.50 to 1.00 mg/kg; and group 4, 1.00 to 2.00 mg/kg. Arterial blood pressures, glomerular filtration rate (GFR), and renal plasma flow were determined before treatment and during the treatment period. Other determinants of renal hemodynamics were measured by use of micropuncture techniques. Renal biopsy specimens were examined microscopically.


RESULTS
Compared with cats that received placebo, mean systolic arterial blood pressure was significantly less and GFR significantly greater in cats that received benazepril. Glomerular capillary pressure and the ratio of efferent to afferent arteriolar vascular resistance were also significantly less in treated cats. However, histologic differences in renal specimens were not detected.


CONCLUSIONS
Treatment with benazepril sustained single nephron GFR in remnant nephrons of cats with induced renal insufficiency. Administration of benazepril was also associated with a small but significant reduction in degree of systemic hypertension and an increase in whole kidney GFR. Benazepril may be an effective treatment to slow the rate of progression of renal failure in cats with renal disease.
Department of Physiology and Pharmacology, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
S A
SA
Brown
C A
CA
Brown
G
G
Jacobs
J
J
Stiles
R S
RS
Hendi
S
S
Wilson
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology*; D000818:Animals; D001552:Benzazepines / Q000494:pharmacology*; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D002371:Cat Diseases / Q000188:drug therapy / Q000503:physiopathology*; D002415:Cats; D003404:Creatinine / Q000097:blood / Q000652:urine; D004452:Echocardiography / Q000662:veterinary; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects / Q000662:veterinary; D006339:Heart Rate / Q000187:drug effects; D006977:Hypertension, Renal / Q000209:etiology / Q000517:prevention & control; D007674:Kidney Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D011897:Random Allocation; D017595:Renal Plasma Flow / Q000187:drug effects; D013686:Telemetry / Q000662:veterinary
D000806:Angiotensin-Converting Enzyme Inhibitors; D001552:Benzazepines; D003404:Creatinine; C044946:benazepril