Radiation damage in DNA: possible role of higher triplet states.
Triplet states of deoxyribose are expected to dissociate efficiently into radicals, leading to strand breaks. Such states could be excited by slow secondary electrons (A) or result from ion recombination in spurs containing two or more ion pairs (B). Estimates of the efficiencies of these processes are presented and the mechanisms discussed in the light of recent work with electrons, vacuum ultraviolet (VUV) photons, and X rays. Route B could play a significant role in producing double-strand breaks, while route A may be a better approach to characterizing the process experimentally.
Brocklehurst
B
B
Chemistry Department, The University of Sheffield, Sheffield S3 7HF, United Kingdom.
D019457:Chromosome Breakage; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D003855:Deoxyribose / Q000528:radiation effects; D004583:Electrons; D018499:Linear Energy Transfer; D017785:Photons
D003855:Deoxyribose; D004247:DNA