[State of lipid peroxidation and antioxidant activity of blood in skin wounds induced by mechanical and radiation injury].
The state of lipid peroxidation and antioxidant system in blood were been studied on the models of skin wound and radioinduced ulcer in rats. It was shown that the healing of skin wound by secondary strength is accompanied by activation of processes lipid peroxidation in plasma and erythrocytes during 15 days. The development of radioinduced ulcer is characterized by more high degree activation of lipid peroxidation beginning with latent period and till forming ulcer (30 days). Only in process of radioinduced ulcer development two phase of activation lipid peroxidation and decrease of antioxidant enzyme activity--catalase and superoxid dismutase--were established. Secondary phase of lipid peroxidation activation was coincided with period of clinical appearances and it was possibly explained by exhaustion of antioxidant system.
Kharkov Medical University, Ukrainian Ministry of Public Health, Kharkov, Ukraine.
T V
TV
Zviagintseva
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002374:Catalase / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D015227:Lipid Peroxidation; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D011832:Radiation Injuries / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000293:injuries*; D012883:Skin Ulcer / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D008055:Lipids; D008074:Lipoproteins; D002374:Catalase; D013482:Superoxide Dismutase