Aniracetam restores motivation reduced by satiation in a choice reaction task in aged rats.
This study aims to examine the effects of aniracetam on satiation-induced poor performance in a choice reaction task. Aged rats that mastered the task under food restriction stably maintained the task performance for a long period. Satiation by successive free feeding greatly diminished the performance. Satiation resulted in a decreased % correct, increased % omission and prolonged choice reaction time, indicating a reduction in lever response with low choice accuracy and slow responding speed. Repeated administration of aniracetam (30 mg/kg, po, for 14 days) partially recovered the choice accuracy and lever response, but not the responding speed, task-associated motor activity or impulsivity. In addition, aniracetam did not affect the animals' weights. These results indicate that satiation reduces motivation to perform and attain the task. Aniracetam may restore motivation, probably by improving poor behavioral states (daily attentional and vigilance failures), thereby creating the driving force.
CNS Supporting Laboratory, Nippon Roche Research Center, 200 Kajiwara, Kamakura, Kanagawa 247-8530, Japan. kazuo.nakamura@roche.com
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D000375:Aging / Q000523:psychology*; D000818:Animals; D001143:Arousal / Q000187:drug effects; D002755:Choice Behavior / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005215:Fasting / Q000523:psychology; D008297:Male; D009042:Motivation; D018697:Nootropic Agents / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects*; D012528:Satiety Response / Q000502:physiology*
D018697:Nootropic Agents; D011760:Pyrrolidinones; C036466:aniracetam