Advances in human cardiac 31P-MR spectroscopy: SLOOP and clinical applications.
Phosphorus magnetic resonance spectroscopy (31P-MRS) has revealed a lot about the biochemistry of physiological and pathological processes in the heart. Nevertheless, until today, cardiac 31P-MRS has not had any clinical impact, albeit some pioneering studies demonstrated that 31P-MRS can indeed provide diagnostic information. In this paper, the development of techniques for human cardiac 31P-MRS over the past decade is reviewed, and the requirements for a reliable clinical measurement protocol are discussed. Spatial localization with optimal pointspread function (SLOOP) is a new method to achieve spatial localization and absolute quantitation. Its properties are detailed, and preliminary findings in patients with dilated cardiomyopathy or myocardial infarction are presented.
von Kienlin
M
M
Institute of Physics, University of Würzburg, Am Hubland, Würzburg, Germany. markus_f_m.von_kienlin@roche.com
Beer
M
M
Greiser
A
A
Hahn
D
D
Harre
K
K
Köstler
H
H
Landschütz
W
W
Pabst
T
T
Sandstede
J
J
Neubauer
S
S
D006331:Heart Diseases / Q000175:diagnosis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010759:Phosphorus Isotopes
D010759:Phosphorus Isotopes