Heat shock proteins: the 'Swiss Army Knife' vaccines against cancers and infectious agents.
The ability of heat shock proteins to: (a) chaperone peptides, including antigenic peptides; (b) interact with antigen presenting cells through a receptor; (c) stimulate antigen presenting cells to secrete inflammatory cytokines; and (d) mediate maturation of dendritic cells, makes them a one-stop shop for the immune system. These properties also permit the utilization of heat shock proteins for development of a new generation of prophylactic and therapeutic vaccines against cancers and infectious diseases.
Srivastava
P K
PK
Center for Immunotherapy of Cancer and Infectious Diseases, University of Connecticut School of Medicine, Farmington, CT 06030-1601, USA. srivastava@nso2.uchc.edu
Amato
R J
RJ
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D019496:Cancer Vaccines / Q000276:immunology / Q000302:isolation & purification* / Q000494:pharmacology; D003140:Communicable Disease Control; D003141:Communicable Diseases / Q000276:immunology* / Q000628:therapy; D006360:Heat-Shock Proteins / Q000276:immunology* / Q000627:therapeutic use*; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009336:Necrosis; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*
D000276:Adjuvants, Immunologic; D019496:Cancer Vaccines; D006360:Heat-Shock Proteins