Use of a capillary rheometer to evaluate the rheological properties of microcrystalline cellulose and silicified microcrystalline cellulose wet masses.
The influence of microcrystalline cellulose (MCC) type and water content on the rheological properties of the wet powder masses were studied using two different MCC grades (Avicel and Emcocel) and silicified microcrystalline cellulose (SMCC, Prosolv). A ram extruder was used as a capillary rheometer and unique flow curves for each cellulose grade and moisture content were derived. In addition, the elastic parameters of recoverable shear and compliance were determined. From different flow curve models evaluated, it was not possible to obtain clear evidence, which model best described the rheological properties of each cellulose grade at each water level. Furthermore, the residuals were shear rate dependent, which indicates that the models do not perfectly agree with physical properties of the wet masses. The elastic properties of wet masses increased with increasing water content and decreased with increasing shear stresses. SMCC grade proved to be more elastic than the simple MCC grades at each moisture content. Thus, the rheological properties of MCC and SMCC wet masses were different and changed with water content. Consequently, it was not possible to achieve similar rheological properties between different grades of cellulose by altering the water content of the wet mass.
Department of Pharmacy, Pharmaceutical Technology Division, P.O. Box 56, 00014 University of Helsinki, Finland. pirjo.luukkonen@helsinki.fi
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Luukkonen
J M
JM
Newton
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Podczeck
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Yliruusi
D002482:Cellulose / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005079:Excipients; D012212:Rheology / Q000187:drug effects*; D014783:Viscosity
D005079:Excipients; D002482:Cellulose; C109691:microcrystalline cellulose