Haemodynamic effects of pan masala in healthy volunteers.
OBJECTIVE
We studied acute haemodynamic effects of pan masala (powdered mixture of areca nut, slaked lime, catechu, and condiments) in healthy volunteers.


METHODS
Fifty one males (mean age 28.6 +/- 10 years) were evaluated. One pouch (4 g) of pan masala without tobacco was given to each subject under fasting state and effects on pulse and blood pressure (BP) recorded.


RESULTS
At baseline the pulse rate was 75.1 +/- 9.0 per minute, systolic BP was 119.1 +/- 10.8 mm Hg, and diastolic BP was 78.0 +/- 7.5. The pulse rate increased to 87.5 +/- 11.4 at ten minutes (+16.9 +/- 12.6%, p < 0.001) and fell to 76.7 +/- 9.1 at 30 minutes (p = ns). Systolic BP increased to 122.3 +/- 11.7 mm Hg at 10 minutes (+2.73 +/- 5.1%, p < 0.001) and was 120.8 +/- 10.8 at 30 minutes; while diastolic BP was 80.8 +/- 7.3 at 10 minutes (+3.83 +/- 6.1%, p < 0.001) and 79.4 +/- 7.6 at 30 minutes.


CONCLUSIONS
Pan masala intake causes acute increase in pulse and BP.
Department of Nephrology, Monilek Hospital and Research Center, Jawahar Nagar, Jaipur-302 004.
A K
AK
Sharma
R
R
Gupta
H P
HP
Gupta
A K
AK
Singh
D000328:Adult; D001114:Areca / Q000009:adverse effects; D002126:Calcium Hydroxide / Q000009:adverse effects; D002392:Catechin / Q000009:adverse effects; D005526:Food, Formulated / Q000009:adverse effects*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010946:Plants, Medicinal; D017365:Spices / Q000009:adverse effects
D002392:Catechin; D002126:Calcium Hydroxide