Anti-androgenic activity of Myricae Cortex--isolation of active constituents from bark of Myrica rubra.
The aqueous ethanol extract of Myricae Cortex (bark of Myrica rubra Sieb. et Zucc., Myricaceae) showed in vitro testosterone 5alpha-reductase inhibitory activity and in vivo anti-androgenic activity using growth of flank organ in castrated Syrian hamsters and/or hair regrowth after shaving in testosterone-treated C57Black/6CrSlc mice. Three constituents, myricanone, myricanol, and myricetin were identified as the main active principles.
Matsuda
H
H
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan. matsuda@phar.kindai.ac.jp
Yamazaki
M
M
Matsuo
K
K
Asanuma
Y
Y
Kubo
M
M
D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D002681:China; D006224:Cricetinae; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006128:Growth / Q000187:drug effects; D006197:Hair / Q000254:growth & development; D007202:Indicators and Reagents; D008297:Male; D008647:Mesocricetus; D051379:Mice; D008810:Mice, Inbred C57BL; D009919:Orchiectomy; D019441:Plant Epidermis / Q000737:chemistry; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017207:Rats, Sprague-Dawley
D058891:5-alpha Reductase Inhibitors; D000726:Androgen Antagonists; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D010936:Plant Extracts