Outcomes following staged bilateral pallidotomy in advanced Parkinson's disease.
The authors assessed clinical outcome for up to one year after staged bilateral pallidotomy in 14 patients with advanced PD. One year after surgery, dyskinesias were virtually abolished and there were significant reductions in "off" time (67%) and activities of daily living "off" scores (24%), as well as nonsignificant reduction in "off" motor score (39%); "on" scores were unchanged. One patient developed a visual field deficit; two had transient confusion. Staged bilateral pallidotomy improves motor function in selected patients with advanced PD.
Counihan
T J
TJ
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, USA. timothy_counihan@urmc.rochester.edu
Shinobu
L A
LA
Eskandar
E N
EN
Cosgrove
G R
GR
Penney
J B
JB
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D007839:Functional Laterality / Q000502:physiology; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009068:Movement / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery*; D011379:Prognosis