Molecular dissection of autophagy: two ubiquitin-like systems.
Recent analyses of the genes required for autophagy--intracellular bulk protein degradation--in yeast have revealed two ubiquitin-like systems, both of which are involved in the membrane dynamics of the process. Molecular dissection of these systems is now revealing some surprises.
Department of Cell Biology, National Institute for Basic Biology, Myodaiji, Okazaki, 444-8585, Japan. yohsumi@nibb.ac.jp
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D001343:Autophagy / Q000502:physiology*; D000071193:Autophagy-Related Protein 7; D000071190:Autophagy-Related Protein 8 Family; D008247:Lysosomes / Q000378:metabolism; D008854:Microscopy, Electron; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000502:physiology* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins; D014452:Ubiquitins / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism
C114830:ATG7 protein, S cerevisiae; C113757:ATG8 protein, S cerevisiae; D000071190:Autophagy-Related Protein 8 Family; D008869:Microtubule-Associated Proteins; D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins; D014452:Ubiquitins; D000071193:Autophagy-Related Protein 7