Recurrence risks to sibs of MS index cases: impact of consanguineous matings.
Using population-based data, the authors identified 24 MS index cases whose parents were related. Twenty-two had 67 sibs of whom 6 also had MS, yielding a recurrence risk of approximately 9%, significantly higher than for sibs of MS index cases from nonconsanguineous parents. These findings support the concept that multiple interacting genes increase the risk of MS.
Department of Medical Genetics, University of British Columbia, Vancouver, Canada. sadovnik@infinet.net
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Dessa Sadovnick
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D003241:Consanguinity; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics* / Q000503:physiopathology*; D009679:Nuclear Family; D012008:Recurrence; D012307:Risk Factors