Pharmacokinetics of intragastric ipriflavone solid dispersion in rats.
OBJECTIVE
To evaluate pharmacokinetic behavior of ipriflavone solid dispersion in rats.


METHODS
The plasma concentrations of ipriflavone in rats were determined by HPLC with UV detector.


RESULTS
Plasma concentration-time curves after ig ipriflavone solid dispersion 250 mg.kg-1 in rats were fitted with one-compartment model. Pharmacokinetic parameters were as follows: Ke = 0.21 h-1, T1/2Ke = 5.19 h, Ka = 1.71 h-1, T1/2Ka = 0.41 h, Tmax = 0.67 h, Cmax = 429 micrograms.L-1, AUC = 3916 micrograms.h.L-1; The relative bioavailability of ipriflavone solid dispersion was 323%.


CONCLUSIONS
Ipriflavone in solid dispersion was absorbed more effectively than that in physical mixture in rats.
Li
Y P
YP
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China. ypli@server.shcnc.ac.cn
Zhou
J J
JJ
Zhang
X Y
XY
Pei
Y Y
YY
D000818:Animals; D001682:Biological Availability; D016723:Bone Remodeling; D007529:Isoflavones / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D007529:Isoflavones; C018986:ipriflavone