Four patients with AL amyloidosis treated with high-dose chemotherapy and autologous stem cell transplantation.
Four patients with AL amyloidosis underwent high-dose chemotherapy and autologous stem cell transplantation at our institutions. Here, we report the clinical courses and outcomes in these patients. Two patients with multi-organ amyloid deposits including cardiac involvement died within 12 days after high-dose chemotherapy. However, in the other two patients, one of whom was suffering from amyloid-related cardiac failure, a significant improvement of organ function was achieved.
Charité University Hospital, Department of Haematology, Oncology and Tumour Immunology, Humboldt University of Berlin, Germany.
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G
Reich
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Held
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Siegert
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Kampf
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Dörken
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Maschmeyer
D000328:Adult; D000682:Amyloid; D000686:Amyloidosis / Q000150:complications / Q000628:therapy*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D005260:Female; D006333:Heart Failure / Q000209:etiology / Q000473:pathology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D014182:Transplantation, Autologous; D016896:Treatment Outcome
D000682:Amyloid; C033048:amyloid protein AR, human