Hormonal contraception in the male.
The hormonal approach to male contraception is based on the suppression of gonadotrophin secretion with secondary suppression of spermatogenesis. This can be achieved by administration of testosterone or other androgen alone, but combined administration with a progestogen or GnRH analogue allows the dose of testosterone to be reduced to physiological replacement doses. This approach has been investigated for many years but without identification of a regimen which results in sufficient suppression of spermatogenesis to provide ensured contraception in all men, safely and conveniently. The reasons for this are discussed, and recent developments towards a regimen that fulfills all these criteria are described. Crucial to development of any new product is that it will be used: surveys of both men and women indicate firmly positive attitudes towards a 'male pill'. There are, therefore, grounds for cautious optimism that the next decade may see the introduction of the first novel male contraceptive for several hundred years.
MRC Human Reproductive Sciences Unit, Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers Street, Edinburgh EH3 9ET, UK.
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Anderson
D000152:Acne Vulgaris / Q000139:chemically induced; D000988:Antispermatogenic Agents / Q000008:administration & dosage*; D004343:Drug Implants; D006065:Gonadotropins, Pituitary / Q000037:antagonists & inhibitors*; D007722:Health Knowledge, Attitudes, Practice; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D020249:Hormone Replacement Therapy; D006801:Humans; D008297:Male; D009277:Nandrolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D009845:Oligospermia / Q000139:chemically induced; D013739:Testosterone / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000737:chemistry; D015430:Weight Gain
D000988:Antispermatogenic Agents; D004343:Drug Implants; D006065:Gonadotropins, Pituitary; D006454:Hemoglobins; C050320:testosterone 4-n-butylcyclohexylcarboxylic acid; D013739:Testosterone; C064709:trestolone; D009277:Nandrolone