[The experimental research of inner ear metabolism and electrical physiology of autoimmune sensorineural hearing loss].
Inquire into the mechanism of inner ear pathological physiology in autoimmune sensorineural hearing loss (ASHL). With the auditory electric-physiological techniques and enzyme-histochemical method, the change of inner ear hearing function and enzyme activity were observed. These animals, which threshold of auditory nerve compound active potential (CAP) and cochlear microphonic potential(CM) heightening evidently, showed that the amplitude of endolymphatic potential(EP) (include-EP) bring down in various degrees, which was related to the change of the active of Na(+)-K(+)-ATPase and SDH in vascularis stria and endolymphatic sac. The abnormality of enzymes metabolism in inner ear tissues, which following autoimmune inflammation damage, is the pathological foundation of hearing dysfunction.
Department of Otorhinolaryngology, Affiliated Hospital of Nanjing Railway Medical College, Nanjing 210009.
C
C
Tan
Y
Y
Cao
P
P
Hu
D000200:Action Potentials; D000818:Animals; D001327:Autoimmune Diseases / Q000201:enzymology / Q000503:physiopathology*; D003055:Cochlear Microphonic Potentials; D003056:Cochlear Nerve / Q000503:physiopathology; D004712:Endolymphatic Sac / Q000503:physiopathology; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000201:enzymology / Q000209:etiology / Q000503:physiopathology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013316:Stria Vascularis / Q000201:enzymology / Q000502:physiology; D013385:Succinate Dehydrogenase / Q000378:metabolism
D013385:Succinate Dehydrogenase; D000254:Sodium-Potassium-Exchanging ATPase