Tumor angiogenesis related to growth pattern and lymph node metastasis in early gastric cancer.
OBJECTIVE
To investigate the correlation between angiogenesis and tumor growth pattern as well as the lymph node metastasis to reveal the significance of vascularity in the early stage of gastric cancer.


METHODS
97 specimens from patients with early gastric cancer were studied by immunohistochemical method using anti-factor VIII related antigen antibody.


RESULTS
Microvessel count was related to tumor growth pattern. The mean vessel count was higher in superficially spreading and penetrating types of tumors. Lymph node metastasis was correlated to microvessel count. Tumors with lymph node metastasis had higher microvessel counts than those without lymph node metastasis.


CONCLUSIONS
In the early stage of gastric carcinoma, angiogenesis is correlated with tumor growth pattern and lymph node metastasis. Identification of tumors with high density of vascularization is beneficial for closer follow-up and adjuvant therapy.
Che
X
X
First Department of Surgery, School of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-0075 Japan.
Hokita
S
S
Natsugoe
S
S
Tanabe
G
G
Baba
M
M
Takao
S
S
Aikou
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D013274:Stomach Neoplasms / Q000098:blood supply / Q000473:pathology*