Effect of novel water-soluble polymeric forms of sorbic acid against Fusarium oxysporum f.sp. radicis-cucumerinum.
New controlled release water-soluble formulations of sorbic (2,4-hexadienoic) acid were prepared and their inhibitory activity on mycelium growth of Fusarium oxysporum f.sp. radicis-cucumerinum was evaluated. The new products are epoxidized polymers of polyvinylpyrrolidone (PVP) containing covalently bonded sorbic acid (polymeric esters of sorbic acid) and complexes of PVP with hydrogen bonded sorbic acid, characterized by controlled release of sorbic acid. It was shown that the polymeric complexes of sorbic acid with PVP were more effective fungicidal agents than sorbic acid polymeric esters. In all cases the activity of polymeric derivatives (esters and complexes) was increased by lowering the molecular weight of the polymeric carriers. Controlled release formulations of these polymeric derivatives are new promising products due to their low toxicity, wide range of efficient concentrations for application and ability to regulate lyophilicity. Our data contribute to the understanding of the action mechanism of various polymeric sorbic acid formulations and can result in products which are particularly suitable for food and feed protection applications.
Laboratory of Toxicology, Department of Medicine, University of Crete, Voutes 71409 Heraklion, Crete, Greece.
M N
MN
Tzatzarakis
A M
AM
Tsatsakis
M M
MM
Lotter
M I
MI
Shtilman
D J
DJ
Vakalounakis
D003692:Delayed-Action Preparations; D005520:Food Preservatives / Q000737:chemistry / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects*; D009181:Mycoses / Q000382:microbiology / Q000517:prevention & control*; D010935:Plant Diseases / Q000382:microbiology; D013011:Sorbic Acid / Q000737:chemistry / Q000494:pharmacology*; D014675:Vegetables / Q000382:microbiology
D003692:Delayed-Action Preparations; D005520:Food Preservatives; D013011:Sorbic Acid