Molecular mechanisms of apolipoprotein B mRNA editing.
A site-specific post-transcriptional cytidine to uridine deamination reaction is responsible for the production of apolipoprotein B48 in the mammalian small intestine. The molecular machinery responsible for apolipoprotein B RNA editing consists of apobec-1, an RNA-specific cytidine deaminase that functions in conjunction with a recently identified protein referred to as ACF/ASP. These proteins together represent the minimal editing enzyme, although other proteins may associate with the enzyme complex. Apobec-1 is a member of a supergene family of cytidine deaminases, with several homologs recently identified in the human genome. ACF/ASP is novel, and emerging information reveals interesting clues to its role in the apolipoprotein B RNA editing enzyme complex.
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA.
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D001055:Apolipoproteins B / Q000235:genetics* / Q000378:metabolism; D020029:Base Pairing; D001483:Base Sequence; D003562:Cytidine; D008074:Lipoproteins / Q000378:metabolism; D008969:Molecular Sequence Data; D017393:RNA Editing; D012333:RNA, Messenger / Q000737:chemistry / Q000235:genetics*; D014529:Uridine
D001055:Apolipoproteins B; D008074:Lipoproteins; D012333:RNA, Messenger; D003562:Cytidine; D014529:Uridine