Surgical treatment of hypothalamic hamartoma and refractory seizures: a case report and review of the literature.
Refractory gelastic seizures are often associated with hypothalamic hamartoma (HH). Presurgical evaluation in such children often points to a distinct cortical region as the source of the seizures. A case of a child with HH and refractory seizures is presented. Video-EEG monitoring revealed a well-defined epileptic focus in the left frontal region. In accordance with the current understanding of the nature of hamartoma-related seizures, the hamartoma was resected. Follow-up evaluations revealed a marked improvement in seizure frequency and global functioning.
Child Developmental Center and Pediatric Neurology Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. umkramer@netvision.net.il
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U
Kramer
S
S
Spector
W
W
Nasser
V
V
Siomin
I
I
Fried
S
S
Constantini
D002675:Child, Preschool; D003241:Consanguinity; D003937:Diagnosis, Differential; D004569:Electroencephalography; D020195:Epilepsy, Reflex / Q000209:etiology / Q000235:genetics / Q000601:surgery*; D006222:Hamartoma / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D006801:Humans; D007027:Hypothalamic Diseases / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D007031:Hypothalamus / Q000473:pathology / Q000601:surgery; D007845:Laughter; D008279:Magnetic Resonance Imaging; D008297:Male; D013686:Telemetry; D014741:Video Recording