Cytogenetic profile of primary pituitary germinoma.
We present a case of a germinoma in the sellar region of a 10-year-old female patient who presented with a history of polydipsia, polyuria and visual disturbances. The tumor was resected and histologically analyzed. Interphase cytogenetics was performed using chromosome specific (peri)-centromeric DNA probes for all the somatic and X chromosomes on fresh frozen tissues. Fluorescent in situ cell hybridization demonstrated accumulated cytogenetic abnormalities involving significant alterations of chromosome 1, 4, 5/19 and 15. The child was treated postoperatively by radiation and now appears well with only minor neurological deficits. At 3-year follow-up no recurrent tumor mass could be demonstrated.
Department of Pathology, Medical School, University of Pećs, Hungary. elmont@pathology.pote.hu
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Gömöri
D J
DJ
Halbauer
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Dóczi
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Balázs
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Kajtár
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Pajor
D002648:Child; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002884:Chromosomes, Human, Pair 15 / Q000235:genetics; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D020732:Cytogenetic Analysis / Q000379:methods*; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D018237:Germinoma / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008279:Magnetic Resonance Imaging; D008677:Metaphase; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000235:genetics*
D004273:DNA, Neoplasm