[Recurrent coumarin necrosis in type II protein S deficiency].
Coumarin necrosis is a rare but clinical very important complication of therapy with coumarin derivatives. We report a patient with congenital protein S deficiency type II, who developed coumarin necrosis during stabilization of phenprocoumon. Diagnostic problems and therapeutic alternatives are discussed considering the recent literature.
Seyfarth
H J
HJ
Medizinische Klinik und Poliklinik I, Universität Leipzig und Innere Abteilung des evangelisch-lutherischen Diakonissenkrankenhauses zu Leipzig.
Siegemund
A
A
Helling
L
L
Woinke
M
M
Pfeiffer
D
D
Rühlmann
C
C
D000328:Adult; D003937:Diagnosis, Differential; D006579:Heterozygote; D006801:Humans; D008297:Male; D009336:Necrosis; D010644:Phenprocoumon / Q000008:administration & dosage / Q000009:adverse effects*; D018455:Protein S Deficiency / Q000175:diagnosis / Q000235:genetics*; D012867:Skin / Q000473:pathology*; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000175:diagnosis
D010644:Phenprocoumon