The biological chemistry of lead.
Recent biophysical studies on the interactions between lead and recombinant proteins and peptides that naturally bind zinc or calcium have provided unparalleled insights into the biological chemistry and molecular toxicology of lead. These studies lay the foundation for the rational design of improved methods for detecting and treating lead poisoning.
Department of Chemistry, Northwestern University, Evanston, IL 60208-3113, USA. h-godwin@northwestern.edu
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D000818:Animals; D001682:Biological Availability; D002118:Calcium / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007854:Lead / Q000737:chemistry / Q000378:metabolism*; D007855:Lead Poisoning / Q000175:diagnosis* / Q000628:therapy; D000623:Porphobilinogen Synthase / Q000737:chemistry* / Q000378:metabolism; D011485:Protein Binding / Q000502:physiology*; D011493:Protein Kinase C / Q000737:chemistry* / Q000378:metabolism; D015032:Zinc / Q000737:chemistry / Q000378:metabolism
D007854:Lead; D011493:Protein Kinase C; D000623:Porphobilinogen Synthase; D015032:Zinc; D002118:Calcium