Intravenous ketamine attenuates arterial pressure changes during the induction of anaesthesia with propofol.
OBJECTIVE
To investigate whether the administration of ketamine before induction with propofol produces a smaller decrease in arterial pressure.


METHODS
Twenty-two patients were assigned to one of two groups to receive either propofol with ketamine (n = 11) or propofol alone (n = 11, control). Anaesthesia was induced with 2 mg kg-1 propofol and 0.5 mg kg-1 ketamine or 2 mg kg-1 propofol alone. Ketamine was administered 1 min prior to induction with propofol. Immediately after induction with propofol, vecuronium (0.15 mg kg-1) was administered. Four minutes after administration of vecuronium, tracheal intubation was performed. Anaesthesia was maintained using sevoflurane (0.5%) in 66% nitrous oxide until 3 min after intubation. Systolic, diastolic and mean arterial pressure and heart rate were recorded on arrival, directly before induction with propofol, prior to tracheal intubation, immediately after intubation and at 3 min after intubation.


CONCLUSIONS
Administration of ketamine before induction with propofol preserved haemodynamic stability compared with induction with propofol alone.
Department of Anaesthesia, Yamanashi Medical University, Yamanashi, Japan.
A
A
Furuya
T
T
Matsukawa
M
M
Ozaki
T
T
Nishiyama
M
M
Kume
T
T
Kumazawa
D000758:Anesthesia / Q000009:adverse effects*; D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000009:adverse effects*; D001794:Blood Pressure / Q000187:drug effects*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D016343:Monitoring, Intraoperative; D015742:Propofol / Q000009:adverse effects*
D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D007649:Ketamine; D015742:Propofol