Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation.
Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.
Buckley
C D
CD
Division of Immunity and Infection, MRC Centre for Immune Regulation, University of Birmingham, Birmingham, UK B15 2TT. c.d.buckley@bham.ac.uk
Pilling
D
D
Lord
J M
JM
Akbar
A N
AN
Scheel-Toellner
D
D
Salmon
M
M
D000210:Acute-Phase Reaction / Q000276:immunology*; D000818:Animals; D005347:Fibroblasts / Q000276:immunology*; D006801:Humans; D007249:Inflammation / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*