Involvement of GABAergic neurotransmission in the neurobiology of the apomorphine-induced aggressive behavior paradigm, a model of psychotic behavior in rats.
The effect of treatment with the acute GABAA receptor agonist THIP and the GABAB receptor agonist baclofen on apomorphine-induced aggressive behavior was studied in adult male Wistar rats. Both THIP (10 mg/kg i.p.) and baclofen (8 mg/kg i.p.) attenuated the aggressiveness, thereby indicating the involvement of GABAergic neurotransmission in the mediation of apomorphine-induced aggressiveness. On the basis of our data it can be proposed that both GABAA and GABAB receptor subtypes are involved in the neurobiology of apomorphine-induced aggressive behavior, as this phenomenon is evidently subject to the general inhibitory effect of GABAergic neurotransmission.
Department of Pharmacology, University of Tartu, Tartu, Estonia.
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R
Rudissaar
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K
Pruus
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T
Skrebuhhova-Malmros
L
L
Allikmets
V
V
Matto
D000374:Aggression / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D001058:Apomorphine; D001418:Baclofen / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D004195:Disease Models, Animal; D018755:GABA Agonists / Q000494:pharmacology*; D007555:Isoxazoles / Q000494:pharmacology*; D008297:Male; D018377:Neurotransmitter Agents / Q000096:biosynthesis / Q000502:physiology; D011618:Psychotic Disorders / Q000503:physiopathology; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000187:drug effects; D018080:Receptors, GABA-B / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects*
D018755:GABA Agonists; D007555:Isoxazoles; D018377:Neurotransmitter Agents; D011963:Receptors, GABA-A; D018080:Receptors, GABA-B; D001418:Baclofen; C015542:gaboxadol; D001058:Apomorphine