Evaluation and optimisation of a target-controlled infusion system for administering propofol to dogs as part of a total intravenous anaesthetic technique during dental surgery.
The performance of a modified target-controlled infusion system was investigated in 16 dogs undergoing routine dental work, by comparing the predicted concentrations of propofol in venous blood samples with direct measurements; the optimum targets for the induction and maintenance of anaesthesia were also identified. The performance of a target-controlled infusion system is considered clinically acceptable when the median prediction error, a measure of bias, is not greater than +/-10 to 20 per cent, and the median absolute performance error, a measure of the accuracy, is not greater than 20 to 30 per cent. The results fell within these limits indicating that the system performed adequately. The optimal induction target was 3 microg/ml, and anaesthesia of adequate depth and satisfactory quality was achieved with maintenance targets of between 2.5 and 4.7 microg/ml propofol. The system was easy to use and the quality of anaesthesia was adequate for dental work.
Zeneca Pharmaceuticals, Macclesfield, Cheshire.
T
T
Beths
J B
JB
Glen
J
J
Reid
A M
AM
Monteiro
A M
AM
Nolan
D000771:Anesthesia, Intravenous / Q000379:methods*; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000818:Animals; D003198:Computer Simulation; D003729:Dental Care / Q000662:veterinary*; D004285:Dogs; D005260:Female; D007260:Infusion Pumps / Q000662:veterinary; D008297:Male; D015742:Propofol / Q000008:administration & dosage* / Q000493:pharmacokinetics
D018686:Anesthetics, Intravenous; D015742:Propofol