Effects of temperature on polyunsaturation in cytostatic lipids of Haslea ostrearia.
Unusual chemicals produced by the-'blue oyster' diatom, Haslea ostrearia, include the water-soluble blue pigment marennine and numerous polyunsaturated sesterterpene oils or haslenes. Aqueous extracts of the alga exhibit in vitro and in vivo activities against human lung cancer cells and anti-HIV effects. Here we report that three haslenes also demonstrate in vitro cytostatic action against a human lung cancer cell line. The most active haslene is the most unsaturated and unsaturation in the haslenes increases with increasing algal growth temperature.
Department of Environmental Sciences, University of Plymouth, UK. s.rowland@plymouth.ac.uk
S J
SJ
Rowland
S T
ST
Belt
E J
EJ
Wraige
G
G
Massé
C
C
Roussakis
J M
JM
Robert
D000475:Alkenes / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell; D002470:Cell Survival / Q000187:drug effects; D017377:Diatoms / Q000737:chemistry*; D006678:HIV / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology; D013816:Thermodynamics; D014407:Tumor Cells, Cultured
D000475:Alkenes; D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D010938:Plant Oils; D013729:Terpenes