Selective electrocatalytic oxidation of N-alkyl-N-methylanilines to N-alkylformanilides using nitroxyl radical.
Electrocatalytic oxidation of N-alkyl-N-methylanilines was studied using 4-benzoyloxy-2,2,6,6-tetramethyl-piperidinyl-N-oxyl as a nitroxyl radical. The reaction with N-alkyl-N-methylanilines led to direct formation of N-alkylformanilides in the presence of H2O in reaction media in adequate conversion (>75.8%), high current efficiency (>89.2%) and high selectivity (>93.8%).
Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. kashi@mail.pharm.tohoku.ac.jp
Y
Y
Kashiwagi
J
J
Anzai
D000813:Anilides / Q000138:chemical synthesis*; D000814:Aniline Compounds / Q000138:chemical synthesis*; D002384:Catalysis; D004563:Electrochemistry; D005609:Free Radicals / Q000737:chemistry; D009589:Nitrogen Oxides / Q000737:chemistry; D010084:Oxidation-Reduction
D000813:Anilides; D000814:Aniline Compounds; D005609:Free Radicals; D009589:Nitrogen Oxides; C039900:nitroxyl