Adeno-associated virus is associated with a lower risk of high-grade cervical neoplasia.
Adeno-associated virus (AAV) is a ubiquitous human helper-dependent parvovirus which may interact with human papillomaviruses (HPV) to modify a woman's risk of cervical neoplasia. This analysis was nested in a cohort study of low-income women receiving Pap smears as part of their family planning services. We selected cases (55 with high-grade cervical squamous intraepithelial lesions (HSIL) and 162 with low-grade LSIL) and controls (96 women with normal cervical cytology) and analyzed cervical DNA for AAV, using PCR amplification/dot blot hybridization, and HPV, using hybrid capture I. AAV positivity was associated with a significantly reduced risk of HSIL (age and HPV-adjusted odds ratio (aOR) = 0.32) yet not with LSIL (aOR = 0.78); 53.8% of HSIL, 66.9% of LSIL, and 70.7% of controls were AAV+. AAV appears to interact with HPV to reduce SIL risk; relative to the HPV-/AAV+ exposure, the respective aORs for HSIL and HPV+/AAV-, HPV+/AAV+, and HPV-/AAV+ were 17.0, 6.9, and 3.5. AAV+ was not associated with age, race, HPV status, or sexual or reproductive risk factors. These results strongly suggest that AAV may play a protective or inhibitory role in late stage cervical carcinogenesis. This conclusion needs to be verified in additional epidemiologic studies.
Coker
A L
AL
Department of Epidemiology and Biostatistics, School of Medicine, University of South Carolina, Columbia, 29204, USA.
Russell
R B
RB
Bond
S M
SM
Pirisi
L
L
Liu
Y
Y
Mane
M
M
Kokorina
N
N
Gerasimova
T
T
Hermonat
P L
PL
D000328:Adult; D000554:Ambulatory Care Facilities; D002294:Carcinoma, Squamous Cell / Q000821:virology; D016022:Case-Control Studies; D015331:Cohort Studies; D004279:DNA, Viral / Q000032:analysis; D000229:Dependovirus / Q000235:genetics / Q000302:isolation & purification*; D005260:Female; D006801:Humans; D065006:Papanicolaou Test; D027383:Papillomaviridae / Q000302:isolation & purification; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012959:Socioeconomic Factors; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D014626:Vaginal Smears
D004279:DNA, Viral