A novel fluorinated tryptamine with highly potent serotonin 5-HT1A receptor agonist properties.
Synthesis and biological evaluation of a novel fluorinated tryptamine analogue are described. This new compound 1-(4-fluoro-5-methoxyindol-3-yl)pyrrolidine (2) was found to be a potent serotonin 5-HT1A agonist.
Laban
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Department of Medicinal Chemistry and Molecular Pharmacology, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, IN 47907-1333, USA.
Kurrasch-Orbaugh
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Marona-Lewicka
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Nichols
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DE
D005459:Fluorides / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000378:metabolism*; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D014363:Tryptamines / Q000737:chemistry*
C429405:1-(4-fluoro-5-methoxyindol-3-yl)pyrrolidine; D007211:Indoles; D011759:Pyrrolidines; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; C030820:tryptamine; D005459:Fluorides