[Analysis of stable chromosome aberrations using G-banding stain in lymphocyte of patients with high dose radiation injury].
The analysis was performed on 514 blood lymphocytes from a person accidentally exposed to 137Cs. Blood samples were collected 1 year after exposure three times at intervals of one month. Terminal deletions and simple translocations were found to predominate in all cases. No differences between these cases were observed on analysing total frequency of stable chromosome aberrations. However, the frequency of terminal deletions decreased and frequencies of exchange-type aberration increased with time after exposure. Chromosome #4 was more involved in stable aberrations than it would be expected from the relative chromosome lengths. Clonal aberrations del-ter (5)(q31 or 32) were found.
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249020 Russia. mrrc@obninsk.ru
M A
MA
Ankina
T A
TA
Zavitaeva
T G
TG
Semenova
A V
AV
Sevan'kaev
A E
AE
Baranov
A K
AK
Gus'kova
V Iu
VIu
Nugis
D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D006801:Humans; D008214:Lymphocytes; D008297:Male; D011832:Radiation Injuries / Q000097:blood / Q000235:genetics*