A simple procedure to compute the sample size needed to compare two independent groups when the population variances are unequal.
The usual methods of sample size determination which assume the homogeneity of within-group variances are not sufficiently robust against the violation of this assumption. A method using Satterthwaite's correction for unequal variances is given. It is shown that in the case of unequal variances the minimum total sample size is attained when the allocation ratio is equal to the proportion of the standard deviations.
Clinical Research and Development, Chinoin Pharmaceutical and Chemical Works Ltd., H-1045 Budapest, Tó u. 1-5, Hungary. julia.singer@sanofi-synthelabo.com
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D000704:Analysis of Variance; D015982:Bias; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D006801:Humans; D018401:Sample Size