Sarcomatoid chordoma: chordoma with a massive malignant spindle-cell component.
We report a case of chordoma containing a spindle cell sarcomatoid component with a gradual transition from conventional chordoma. Immunohistochemically, many tumor cells in both conventional chordoma and sarcomatoid components were positive for cytokeratins (AE1/AE3, CAM5.2) and epithelial membrane antigen as well as vimentin. This report provides a rare example of sarcomatoid chordoma. Familiarity with this type of bone tumor should help to avoid confusion with dedifferentiated chordoma and other spindle cell sarcomas or carcinomas.
Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Japan.
Y
Y
Morimitsu
T
T
Aoki
K
K
Yokoyama
H
H
Hashimoto
D000368:Aged; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D002817:Chordoma / Q000175:diagnosis* / Q000532:radiotherapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D012447:Sacrum / Q000000981:diagnostic imaging / Q000473:pathology; D012509:Sarcoma / Q000175:diagnosis* / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed