Cyclosporin, nifedipine and gingival hyperplasia: a randomized controlled study.
Nifedipine increases the frequency and severity of gingival hyperplasia associated with CyA therapy in renal transplant recipients and this effect appears to be independent of whole-blood CyA levels. De novo malignancies have been reported arising in areas of gingival hyperplasia, in a group already at high risk of malignancy. Patients receiving CyA and nifedipine should receive advice regarding the need for strict oral hygiene to control the initial development of gingival hyperplasia, with severe cases being promptly referred for gingivectomy and histological examination.
Morgan
J D
JD
Department of Surgery, Leicester General Hospital, UK.
Swarbrick
M J
MJ
Edwards
C M
CM
Donnelly
P K
PK
D002121:Calcium Channel Blockers / Q000009:adverse effects; D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood; D004347:Drug Interactions; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000145:classification / Q000517:prevention & control; D005890:Gingivectomy; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000097:blood; D016030:Kidney Transplantation / Q000276:immunology*; D009543:Nifedipine / Q000009:adverse effects*; D009910:Oral Hygiene
D002121:Calcium Channel Blockers; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D009543:Nifedipine