Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection.
Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.
Feldmesser
M
M
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. feldmess@aecom.yu.edu
Kress
Y
Y
Casadevall
A
A
D000818:Animals; D003453:Cryptococcosis / Q000378:metabolism / Q000473:pathology*; D003460:Crystallization; D008172:Lung Diseases, Fungal / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016253:Microscopy, Immunoelectron; D011134:Polysaccharides / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
D011134:Polysaccharides