[Acquired partial lipodystrophy. Insulin resistance, hepatic lipase activity and small and dense LDL particles].
Partial lipodystrophy (PLD) is an infrequent condition characterized by symmetric loss of subcutaneous adipose tissue in the upper or lower part of the body, although occasionally it affects only the extremities. In all cases it appears along with acantosis nigricans (AN), insulin resistance and impairment in the metabolism of lipids and carbohydrates. The case depicted pertains to a 49 year old female with no family history involving loss of adipose tissue in face and upper body. No fat in lower part of body was observed. The patient showed facial thinning at age 8, AN at 11 and gestational diabetes during her fourth pregnancy at 33. At present, the patient presents severe hyperglycemia and hyperinsulinemia with a marked insulin resistance. Type IV hyperlipoproteinemia (OMS), declined C-HDL and Apo A1 and low C-LDL but with a high proportion of small and dense LDL particles were present. Non esterified fatty acids were high. Lipoprotein lipase and hepatic lipase activities are in the lower limit and increased respectively. Fraction C3 of the complement was diminished. No mutations were observed either in codons 170, 809 and 972 of the IRS-1 receptor or in codon 276 of the adrenergic beta 2 gene.
Departamento de Bioquímica Clínica, Facultad de Farmacia y Bioquímica, Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, UBA, Junin 956, 1113 Buenos Aires, Argentina. ampaglione@dbc.ffyb.uba.ar
A M
AM
Paglione
N
N
Ferrari
G
G
Berg
G
G
Frechtel
M
M
Taverna
V
V
Fasulo
G I
GI
Lopez
R M
RM
Gomez
O
O
Bruno
M
M
Ruiz
R L
RL
Wikinski
D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008049:Lipase / Q000378:metabolism*; D050356:Lipid Metabolism; D008060:Lipodystrophy / Q000378:metabolism*; D008071:Lipoprotein Lipase / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008875:Middle Aged
D008077:Lipoproteins, LDL; D008049:Lipase; D008071:Lipoprotein Lipase