[Effect of substance P on ethanol consumption in subchronically alcoholized rats in the limited scheduled access paradigm].
The effect of substance P on alcohol intake was studied in rats using a limited scheduled access paradigm. Ascending doses of substance P (100 and 200 micrograms/kg) were administered intraperitoneally to rats approximately 30 minute prior to their 1-hour-per-day access to alcohol. Each dose was administered for 3 successive days, and the effect of substance P was compared to that of saline solution control. Substance P at the dose of 100 micrograms/kg had no effect on alcohol consumption but significantly decreased the alcohol intake at the dose of 200 micrograms/kg. Thus, substance P reduces the alcohol motivation of rats in a limited scheduled access paradigm.
Institute of the Human Brain, Russian Academy of Sciences, Institute for Experimental Medicine, Russian Academy of Medical Sciences, St.-Petersburg.
E P
EP
Bychkov
A A
AA
Lebedev
S A
SA
Dambinova
D000428:Alcohol Drinking; D000818:Animals; D004326:Drinking / Q000187:drug effects; D007274:Injections, Intraperitoneal; D051381:Rats; D017208:Rats, Wistar; D013373:Substance P / Q000008:administration & dosage / Q000494:pharmacology*
D013373:Substance P