Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks.
Signalling pathways based on the small GTPase Ras regulate a multitude of cellular events in eukaryotic cells. Dictyostelium expresses a large and varied family of Ras proteins. It also uses a range of known Ras regulators, in particular RasGEFs, and effectors. The genetic tractability of Dictyostelium, together with the wide range of Ras proteins and regulators, make it an ideal model for the genetic dissection of Ras pathways. This review highlights the recent advances in our understanding of Ras function in Dictyostelium, and considers the implications of these findings for our understanding of eukaryotic signal transduction.
School of Biosciences, Birmingham University, B15 2TT, Birmingham, UK.
J R
JR
Chubb
R H
RH
Insall
D000818:Animals; D004023:Dictyostelium / Q000235:genetics / Q000502:physiology*; D008957:Models, Genetic; D015398:Signal Transduction; D020663:ras Guanine Nucleotide Exchange Factors / Q000502:physiology; D018631:ras Proteins / Q000235:genetics / Q000502:physiology*
D020663:ras Guanine Nucleotide Exchange Factors; D018631:ras Proteins