[Effect of microbial derived agents on the level of blood cytokines, hematological status and survival of mice following combined radiation injury].
Mice models of acute radiation and combined radiation injuries (whole body irradiation + thermal burn) were used for the experiments. Blood serum response of IL-1 beta, TNF-alpha, IL-6, IL-3, and GM-CSF was evaluated after single injection of bacterially derived products (BDPs). As it was established, BDPs revealed different ability for cytokine increasing activity: Imuvert (extract from Serratia marcescens) > synthetic trehalose dicorynomycolate > heat-killed Lactobacillus acidophilus. The capacity of BDPs to enhance survival of animals did not depend on its cytokine-inducing and hematopoietic activities.
Medical Radiological Research Center, Russian Academy of Medical Sciences, Obninsk, 249020 Russia. budagov@obninsk.com
R S
RS
Budagov
L P
LP
Ul'ianova
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D001772:Blood Cell Count; D016207:Cytokines / Q000097:blood*; D006410:Hematopoiesis / Q000276:immunology* / Q000528:radiation effects; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000097:blood* / Q000276:immunology* / Q000401:mortality
D000942:Antigens, Bacterial; D016207:Cytokines