Inhibition of Jak3 tyrosine kinase by PNU156804 blocks rat heart allograft rejection.
Division of Immunology and Organ Transplant, University of Texas-Houston, Houston, Texas, USA.
M
M
Wang
R
R
Kirken
F
F
Behbod
R
R
Erwin-Cohen
S M
SM
Stepkowski
B D
BD
Kahan
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006084:Graft Rejection / Q000517:prevention & control*; D016027:Heart Transplantation / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D053616:Janus Kinase 3; D008297:Male; D011353:Prodigiosin / Q000031:analogs & derivatives / Q000494:pharmacology*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew
C119625:4-benzyloxy-5-((5-undecyl-2H-pyrrol-2-ylidene)methyl)-2,2'-bi-1H-pyrrole; D007166:Immunosuppressive Agents; C507936:Jak3 protein, rat; D011758:Pyrroles; D011505:Protein-Tyrosine Kinases; D053616:Janus Kinase 3; D011353:Prodigiosin