Acylation of indole under Friedel-Crafts conditions-an improved method to obtain 3-acylindoles regioselectively.
[reaction: see text]. The reaction of unsubstituted indole with different acylating agents such as acid chlorides, anhydrides, nitriles, and amino acid derivatives in the presence of Lewis acid is reported.
Instituto de Química, Universidade de Brasília, C. P. 04478, CEP 70910-970, Brasília-DF, Brasil.
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D000215:Acylation; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000737:chemistry*; D002712:Chlorides / Q000737:chemistry*; D007211:Indoles / Q000737:chemistry*; D015394:Molecular Structure; D011108:Polymers / Q000138:chemical synthesis; D012997:Solvents / Q000737:chemistry; D017971:Tin Compounds / Q000737:chemistry*; D014025:Titanium / Q000737:chemistry*
D017607:Aluminum Compounds; D002712:Chlorides; D007211:Indoles; D011108:Polymers; D012997:Solvents; D017971:Tin Compounds; D000077410:Aluminum Chloride; C041694:stannic chloride; C030374:indole; C025096:titanium tetrachloride; D014025:Titanium