Chiral derivatization reagents for drug enantioseparation by high-performance liquid chromatography based upon pre-column derivatization and formation of diastereomers: enantioselectivity and related structure.
Structures and related enantioselectivities of the respective chiral derivatization reagents (CDRs) for drug enantioseparation by high-performance chromatography based upon pre-column derivatization and diastereomeric formation are reviewed. The elution order of diastereomers caused reaction of some CDRs with enantiomeric amino acids and carboxylic acids. The development of new CDRs available for indirect HPLC methods is also discussed. (c) 2001 John Wiley & Sons, Ltd.
Department of Chemical Engineering, Jiangsu Institute of Petrochemical Technology, Changzhou 213016, People's Republic of China.
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D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000737:chemistry / Q000302:isolation & purification*; D012680:Sensitivity and Specificity; D013237:Stereoisomerism
D004364:Pharmaceutical Preparations