[Synthesis of 3-carbethoxi-2-phenyl-4-quinolones. Potential antimitotics].
The synthesis of the title compounds involved four main reactions: condensation between the acid chlorides and diethyl malonate to obtain the diethyl benzoylmalonates; transformation of these in diethyl chloroarylidenmalonates; the reaction of the substituted anilines with the chlorinated compounds and finally the thermal cyclization in diphenyl ether.
Quintero
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Laboratorio de Síntesis, Grupo de Productos Naturales, Centro de Química Orgánica, Facultad de Ciencias, Universidad Central de Venezuela.
Pernía
E
E
Guzmán
W J
WJ
Márquez
C J
CJ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003078:Colchicine / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014404:Tubulin / Q000378:metabolism
D000970:Antineoplastic Agents; D011804:Quinolines; D014404:Tubulin; D003078:Colchicine