[Regulatory mechanisms of erythropoiesis by leukocytes in inflammation].
On the model of carrageenan-induced acute aseptic peritonitis in rats with use of the inhibitors of some leukocytic products it is shown that lysosomal proteinases inhibit erythropoiesis activation in inflammation. Lipoxygenase metabolites stimulate erythropoiesis. Eicosanoids as a whole stimulate erytropoiesis still more. Reactive oxygen species promote the development of erythron hyperplasia. Dexamethasone administration increases the erythropoiesis intensification.
Klimenko
M O
MO
Kharkov State Medical University, Ukraininan Ministry of Health, Kharkov, Ukraine.
Shevchenko
O M
OM
D000208:Acute Disease; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002351:Carrageenan; D003907:Dexamethasone / Q000494:pharmacology; D015777:Eicosanoids / Q000494:pharmacology; D004920:Erythropoiesis / Q000502:physiology*; D007249:Inflammation; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D008247:Lysosomes / Q000201:enzymology; D010538:Peritonitis / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D017382:Reactive Oxygen Species / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D015777:Eicosanoids; D016859:Lipoxygenase Inhibitors; D017382:Reactive Oxygen Species; D003907:Dexamethasone; D002351:Carrageenan