The central mechanism of the depressor-bradycardia effect of "Tinggong.
Roles of central adrenergic receptors and opioid receptors in the depressor-bradycardia effect of 3V, 2Hz "Tinggong-Quchi" electroacupuncture (the EA-DpB, i.e.the depressor bradycardia induced by electroacupuncture) were studied by intracerebroventricula (icv) injection of prazosin, yohimbine or propanol, naloxone or by intra-arachnoid (ith) injection of naloxone. Voltage-dependent depressor effects were induced by 2Hz "Tinggong-Quchi" acupuncture. The depressor effect of 3V, 2Hz " Tinggong-Quchi " acupuncture was attenuated by icv injection of a beta-receptor antagonist-propranolol, but was not blocked by the icv injection of an alpha1 -or (alpha2 -receptor antagonist prazosin or yohimbine. Icv injected naloxone but not ith injected naloxone blocked or reversed the EA-DpB. Results suggest that central P-receptors or opioid receptors in the brain are selectively involved in the EA-DpB.
Zou
C J
CJ
Health Science Center, Peking University, Beijing, PR China.
Wang
H
H
Ge
L
L
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001919:Bradycardia; D002319:Cardiovascular System / Q000187:drug effects; D015671:Electroacupuncture; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D009292:Narcotic Antagonists; D009270:Naloxone; D011433:Propranolol; D011224:Prazosin