Studies on the influence of aneuploidy of spermatozoa obtained from patients with oligozoospermia on their structure.
The presence of aneuploidy in spermatozoa influences their biological characteristics, especially their ability to fertilise the ovum. The aim of the present study was to investigate if aneuploidy is accompanied by any changes in the morphology of spermatozoa in oligozoospermic patients. For this purpose, the percentage of aneuploid cells in sperm and the correlation between the specific morphological forms of spermatozoa and aneuploidy were evaluated. The study proved a negative correlation between DNA content of aneuploid and normal spermatozoa. A weak positive correlation was demonstrated between the presence of aneuploid spermatozoa and DNA content of spermatozoa with large heads. No such correlations could be detected for DNA content of the remaining morphological forms of spermatozoa. Thus, men with a lowered number of spermatozoa and/or with abnormal spermatozoal morphology should have their spermatozoal DNA content tested in order to evaluate the degree of aneuploidy, especially in cases where in vitro fertilisation is intended.
Department of Radiobiology and Cell Biology, University of Medical Sciences, Poznań, Poland.
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Stecewicz
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Warchoł
D000782:Aneuploidy; D004247:DNA / Q000032:analysis; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000235:genetics* / Q000473:pathology*; D013077:Sperm Head / Q000473:pathology*; D013082:Sperm Tail / Q000473:pathology*
D004247:DNA