Alpha4 integrins in cardiovascular development and diseases.
Alpha4 integrins (alpha4beta1 and alpha4beta7) have a restricted distribution pattern and are critical for the development and diseases of the cardiovascular system. alpha4 integrins support unique biological properties such as promoting cell migration and inhibiting cell spreading and focal adhesion formation. We have found that the alpha4 integrin subunit directly and tightly binds to a signaling adapter molecule, paxillin, and disruption of the alpha4-paxillin interaction interferes with many of alpha4-dependent biological functions. Consequently, the interaction of alpha4 integrins with paxillin may play an important role in regulating alpha4-mediated functions. This review focuses on what we have known about the alpha4-paxillin interaction and discusses the possible mechanism of regulation for this interaction.
Department of Vascular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA.
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Liu
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Rose
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Han
M H
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Ginsberg
D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000503:physiopathology*; D002319:Cardiovascular System / Q000196:embryology* / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000378:metabolism / Q000502:physiology; D006801:Humans; D039441:Integrin alpha4; D016023:Integrins / Q000378:metabolism / Q000502:physiology*; D051419:Paxillin; D010750:Phosphoproteins / Q000378:metabolism / Q000502:physiology
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D016023:Integrins; C496061:PXN protein, human; D051419:Paxillin; D010750:Phosphoproteins; D039441:Integrin alpha4