A histometric study in rats of the effect of the calcium antagonist amlodipine on bone healing after tooth extraction.
The purpose was to investigate whether amlodipine, a second-generation calcium antagonist used for the treatment of hypertension and angina, interferes with healing of rat alveolar bone. A progressive increase in volume density of new bone filling the socket was quantified by a histometric differential point-counting method 7-42 days after tooth extraction. The results showed a 20-30% decrease in bone volume fraction in the alveolus of amlodipine-treated animals from 7 days on, in addition to a higher (7-35%) volume fraction of connective tissue and a tendency toward an increase in the volume fraction of persisting coagulum. If confirmed in humans, the knowledge of a deleterious effect of Ca-channel blockers in hindering alveolar bone healing would be important in planning oral operations involving bone tissue, including those for device implantation.
Department of Morphology, Stomatology and Physiology, Faculdade de Odontologia de Ribeirão Preto-USP, Dental School of Ribeirão Preto, University of São Paulo, Av. do Café s/n, 14040-904 Ribeirão Preto, SP, Brazil.
J M
JM
Teófilo
L G
LG
Brentegani
T L
TL
Carvalho
D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects* / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects
D002121:Calcium Channel Blockers; D017311:Amlodipine