Passive ventricular constraint for the treatment of congestive heart failure.
Progressive heart failure is characterized by loss of cardiac function associated with maladaptive changes in myocardial gene expression and neuroendocrine activity, leading to progressive increases in heart size. Elevated ventricular wall stress results from an increase in chamber size, and is thought to play a role in furthering development towards end-stage disease. Reduction of wall stress and stress mediated myocardial stretch may be an important means for mitigating heart failure progression. One possible approach to accomplish this goal is through passive support of the heart with the Cardiac Support Device. Results from preclinical and clinical evaluation give support to this premise.
Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, New York, USA. mco2@columbia.edu
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D002311:Cardiomyopathy, Dilated / Q000601:surgery*; D002986:Clinical Trials as Topic; D005240:Feasibility Studies; D006333:Heart Failure / Q000601:surgery*; D006801:Humans; D013526:Surgical Mesh