[On the problem of prophylaxis of late effects induced by internal irradiation using immunomodulators].
Using the experimental modeling of late effects induced by intake of radionuclides (131I, 238,239Pu, 90Sr) the attempt to investigate the possibility of protection using immune modulators was made. Co-polymer of 2-methil-5-vinilprilidin and N-vinilpirrholidon (sovidon), G immunoglobulin and interferon, Fc fragment of immunoglobulin and S. parathyphi B. Breslau vaccine were used as immune modulators. The positive prophyletie influence of immune modulators was found for average life span, radiation action, immune status, of rates of occurrence and developments of breast tumors induced by 131I, 239Pu and 90Sr. At the same time the increase in osteosarcoma cumulative rate induced by immune modulators in case of body intake of 238Pu and 90Sr was registered.
State Research Center of Russia-Institute of Biophysics, Moscow, 123182 Russia.
V S
VS
Kalistratova
A A
AA
Ivanov
P G
PG
Nisimov
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D007109:Immunity / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000276:immunology*; D011868:Radioisotopes / Q000633:toxicity*; D051381:Rats
D000276:Adjuvants, Immunologic; D011868:Radioisotopes