Inhibition of glucose and dehydroascorbic acid uptakes by resveratrol in human transformed myelocytic cells.
Resveratrol (trans-3,5,4'-trihydroxystilbene) is a natural phytochemical found in grapes and wine. Numerous biological effects of resveratrol have been reported in the last 10 years. In this paper, the competitive inhibition of intracellular uptake of glucose and dehydroascorbic acid in U937 and HL-60 cells by resveratrol is reported.
Phytonutrients Laboratory, Building 307, Room 313, ARS, USDA, Beltsville, MD 20705, USA. park@307.bhnrc.usda.gov
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D000818:Animals; D016466:CHO Cells; D002461:Cell Line, Transformed; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D003683:Dehydroascorbic Acid / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D051272:Glucose Transporter Type 1; D006098:Granulocytes / Q000187:drug effects / Q000378:metabolism; D018922:HL-60 Cells; D006801:Humans; D009004:Monosaccharide Transport Proteins; D000077185:Resveratrol; D013267:Stilbenes / Q000493:pharmacokinetics / Q000494:pharmacology*
D051272:Glucose Transporter Type 1; D009004:Monosaccharide Transport Proteins; C495677:SLC2A1 protein, human; D013267:Stilbenes; D005947:Glucose; D000077185:Resveratrol; D003683:Dehydroascorbic Acid