Nuclear dynamics: where genes are and how they got there.
DNA is highly organized spatially, both within domains of chromatin along each chromosome and within the nucleus as a whole. Recent studies suggest that chromatin localization can affect transcriptional and replicational activity. The similarity between the movements of chromatin nuclear bodies suggests a common mechanism that regulates nuclear dynamics.
Swedlow
J R
JR
Division of Gene Regulation and Expression, Wellcome Trust Biocentre, University of Dundee, Dow Street, Dundee, DD1 5EH, UK. j.swedlow@dundee.ac.uk
Lamond
A I
AI
D021581:Active Transport, Cell Nucleus; D000818:Animals; D002467:Cell Nucleus / Q000235:genetics / Q000378:metabolism*; D022003:Cell Nucleus Structures / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D002843:Chromatin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008954:Models, Biological
D002843:Chromatin