Avascular necrosis of bone in patients with human immunodeficiency virus infection: report of 6 cases and review of the literature.
In 1998 and 1999, we diagnosed avascular necrosis of bone in 6 patients in our human immunodeficiency virus clinic practice, an incidence of 0.45%, which is 45 times greater than would be expected in the general population. Antiphospholipid antibodies and hyperlipidemia secondary to protease inhibitor therapy have been implicated as possible etiologies; however, these abnormalities cannot explain all cases of avascular necrosis of bone reported in patients with human immunodeficiency virus infection.
Brown
P
P
Division of Infectious Disease, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI,USA. pbrown@intmed.wayne.edu
Crane
L
L
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D010020:Osteonecrosis / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology
D017152:Antibodies, Antiphospholipid