Effect of pamidronate in preventing local bone loss after total hip arthroplasty: a randomized, double-blind, controlled trial.
Acute periprosthetic bone loss occurs after total hip arthroplasty. Bone loss undermines the support of the implant and may contribute to prosthetic failure. At present, there is no established prophylaxis for this process. We studied the effect of a single-dose infusion of 90 mg of pamidronate on early periprosthetic bone mineral density (BMD), biochemical markers of bone turnover, radiological, and clinical outcome in a 26-week, prospective, randomized, double-blinded study of 47 men and women undergoing total hip arthroplasty. Pamidronate therapy led to a significant reduction in bone loss compared with placebo for both the proximal femur and the pelvis (repeated measures analysis of variance [ANOVA]); p = 0.001 and p = 0.01, respectively). Pamidronate therapy was associated with suppression of all biochemical markers of bone turnover compared with placebo (repeated measures ANOVA; p < 0.05 for all comparisons), with the exception of urinary free deoxypyridinoline. Pamidronate did not interfere with the clinical improvement in symptoms after total hip arthroplasty, or radiological outcome, and was not associated with an increase in adverse events. This study provides clinical data on the efficacy and safety of bisphosphonates for the prevention of bone loss after total hip arthroplasty and supports the establishment of larger-scale clinical trials to determine the long-term clinical efficacy of this intervention using implant failure as the primary endpoint.
Division of Clinical Sciences,  University of Sheffield, Northern General Hospital, United Kingdom.
J M
JM
Wilkinson
I
I
Stockley
N F
NF
Peel
A J
AJ
Hamer
R A
RA
Elson
N A
NA
Barrington
R
R
Eastell
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood / Q000187:drug effects; D000596:Amino Acids / Q000652:urine; D019644:Arthroplasty, Replacement, Hip; D015415:Biomarkers / Q000032:analysis; D015519:Bone Density; D001862:Bone Resorption; D003094:Collagen / Q000378:metabolism; D004164:Diphosphonates / Q000009:adverse effects / Q000494:pharmacology*; D004311:Double-Blind Method; D005260:Female; D006615:Hip / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000517:prevention & control*; D000077268:Pamidronate; D016896:Treatment Outcome
D000596:Amino Acids; D015415:Biomarkers; D004164:Diphosphonates; C036020:deoxypyridinoline; D003094:Collagen; D000469:Alkaline Phosphatase; D000077268:Pamidronate