[Correlation between sensitivity to fosfomycin and the presence of penicillinase PSE-1 in Pseudomonas aeruginosa].
A prospective survey was carried out during three three-weeks periods in May, October 1997 and October 1998 in 13 teaching hospitals. All non-repetitive isolates of P. aeruginosa collected were subject to serotypage and determination of the inhibiting minimal concentrations for ticarcillin, piperacillin, piperacillin + tazobactam, ceftazidime, imipenem, amikacin, ciprofloxacin and fosfomycin. Identification of the betalactamases and quantification of the cephalosporinase were done for the strains intermediate or resistant to ticarcillin. The most frequent serotypes were O: 6 (17%), O: 11 (13%), O: 1 (10%) and O: 12 (9%). Serotype O: 12 was the least susceptible to antibiotics except for fosfomycin. Whatever the serotype, 76% of P. aeruginosa strains with bla PSE-1 are susceptible to fosfomycin, when only 29.8% of non bla PSE-1 producing strains were susceptible to this antibiotic. Integron encoding bla PSE-1 could be implicated in susceptibility to fosfomycin of P. aeruginosa strains. The associations fosfomycin + imipenem or fosfomycin + ceftazidime could be proposed in case of infections due to P. aeruginosa O: 12.
Laboratoire de Biologie Médicale, Hôpital d'Instruction des Armées Bégin, 69 avenue de Paris, 94160 Saint-Mandé, France.
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D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005578:Fosfomycin / Q000494:pharmacology*; D006784:Hospitals, Teaching; D008826:Microbial Sensitivity Tests; D010405:Penicillinase / Q000032:analysis* / Q000096:biosynthesis; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000187:drug effects* / Q000201:enzymology*; D012703:Serotyping; D001618:beta-Lactamases / Q000032:analysis / Q000096:biosynthesis; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D047090:beta-Lactams; D005578:Fosfomycin; D010405:Penicillinase; C064821:beta-lactamase PSE-1; D001618:beta-Lactamases