Effect of palm oil on plasma lipoprotein concentrations and plasma low-density lipoprotein composition in non-human primates.
Palm oil (PO) contains approximately 43% of palmitic acid. It is the most abundant saturated fatty acid in the diet and it is generally considered the primary cholesterol (C)-raising fatty acid. However, the effect of palmitic acid on plasma cholesterol appears to depend on the cholesterol content of the diet. The aim of this study was to determine the effect of PO with either a high-fat, high-C or moderate-fat, moderate-C diet on lipoprotein C and low-density lipoprotein (LDL) composition. Fifty adult, male vervet monkeys were randomly assigned to the high-fat diet group (HFD: 35%E fat, approximately 0.106 mg C/kJ; n = 30) and the moderate-fat diet group (MFD: 30%E fat, approximately 0.027 mg C/kJ; n = 30). Baseline LDL-C, high-density lipoprotein (HDL)-C and body weight were used to stratify the vervets into comparable experimental groups within each dietary group. The HFD group was divided into two groups of 10 each: one group continued with the HFD in which 8.1%E was derived from lard (AF); in the other group, AF was substituted isocalorically with PO. The MFD group was divided into three groups of 10 each: one group continued with the MFD in which 11.8%E was derived from AF; in the other two groups, the AF was substituted isocalorically with either sunflower oil (SO) or PO. This article presents preliminary results on plasma lipoproteins and LDL composition after 6 months of dietary intervention. Plasma total and LDL-C was higher in all the groups, but the mean changes elicited by PO with either the HFD or MFD were no different from that observed with AF and SO. There was no difference in the mean change of LDL molecular weight within the HFD and MFD. It is concluded that PO is no different from AF (HFD and MFD) or SO (MFD) in its cholesterolaemic effect.
National Research Programme for Nutritional Intervention, Medical Research Council, PO Box 19070, Tygerberg 7505, South Africa.
P J
PJ
van Jaarsveld
C M
CM
Smuts
H Y
HY
Tichelaar
M
M
Kruger
A J
AJ
Benadé
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002522:Chlorocebus aethiops; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000008:administration & dosage; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry / Q000187:drug effects*; D008297:Male; D008970:Molecular Weight; D019308:Palmitic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D008076:Cholesterol, HDL; D004041:Dietary Fats; D008077:Lipoproteins, LDL; D019308:Palmitic Acid