Environmental control of immunological synapse formation and duration.
The coordination of T-cell migration and antigen recognition is crucial for an effective immune response. We have proposed that this coordination is achieved by formation of an immunological synapse between the T cell and the antigen-presenting cell (APC). Our view contrasts with the serial encounter model also proposed in this issue of Trends in Immunology, which is based on transient T cell-APC interactions when surrounded by collagen. Here, we propose a model that reconciles immunological synapse formation and serial encounters based on environmental control of immunological synapse formation.
Dustin
M L
ML
Center for Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St Louis, MO 63110, USA. dustin@saturn.med.nyu.edu
Allen
P M
PM
Shaw
A S
AS
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D002465:Cell Movement / Q000502:physiology; D018925:Chemokines / Q000276:immunology; D003094:Collagen / Q000276:immunology*; D005109:Extracellular Matrix / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D013997:Time Factors
D018925:Chemokines; D011948:Receptors, Antigen, T-Cell; D003094:Collagen