Essential fatty acid composition of plasma phospholipids and birth weight: a study in term neonates.
BACKGROUND
Essential fatty acids (EFAs) in umbilical cord blood samples are associated with attained birth weight in premature infants and low-birth-weight neonates.


OBJECTIVE
The objective was to investigate relations between the EFA composition of cord and maternal plasma phospholipids and birth weight in term neonates.


METHODS
This was a cross-sectional study in 627 singletons born at term. The plasma phospholipid EFA composition of the mothers was determined by gas-liquid chromatography at study entry (< or = 16 wk gestation), at delivery, and in cord plasma at birth. Birth weights were normalized to SD scores.


RESULTS
In cord plasma, the dihomo-gamma-linolenic acid concentration was positively related to weight SD scores. Both arachidonic acid (AA) and docosahexaenoic acid (DHA) were negatively related to weight SD scores. EFA-status indicators showed similar negative associations, whereas eicosatrienoic acid concentrations were positively related to neonatal size. In maternal plasma, proportions of n-3 long-chain polyenes (LCPs) and n-6 LCPs decreased during pregnancy. Larger decreases in AA, DHA, n-3 LCP, and n-6 LCP fractions were observed in mothers of heavier babies. Higher concentrations of LCPs in maternal plasma were, however, not related to a larger infant size at birth.


CONCLUSIONS
A lower biochemical EFA status in umbilical cord plasma and a larger decrease in maternal plasma LCP concentrations are associated with a higher weight-for-gestational-age at birth in term neonates. Our findings do not support a growth-stimulating effect of AA or DHA; however, they do suggest that maternal-to-fetal transfer of EFAs might be a limiting factor in determining neonatal EFA status.
Department of Human Biology and the Nutrition and Toxicology Research Institute Maastricht, Maastricht University, Maastricht, Netherlands. p.rump@hb.unimaas.nl
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D015126:8,11,14-Eicosatrienoic Acid / Q000097:blood; D016718:Arachidonic Acid / Q000097:blood; D001724:Birth Weight; D002849:Chromatography, Gas; D003430:Cross-Sectional Studies; D004281:Docosahexaenoic Acids / Q000097:blood; D005314:Embryonic and Fetal Development; D005228:Fatty Acids, Essential / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D009752:Nutritional Status; D010743:Phospholipids / Q000097:blood* / Q000737:chemistry; D011090:Polyenes / Q000097:blood; D011247:Pregnancy
D005228:Fatty Acids, Essential; D010743:Phospholipids; D011090:Polyenes; D004281:Docosahexaenoic Acids; D016718:Arachidonic Acid; D015126:8,11,14-Eicosatrienoic Acid