Synthesis and biological activity of the structural analogues of (-)-cabenegrin A-I.
A series of phenylbutene and butanol derivatives (6a-j, 12, 13, 15, 17, 24b,c, 26, 27a,b) were prepared from the readily available resorcinol derivatives 2a-f and 7-hydroxy-chroman (18). The products were tested for inhibitory activity on the LPS-induced TNF-alpha production in the plasma in comparison with that of cabenegrin A-I (1a).
Department of Organic Chemistry, University of Debrecen, P.O. Box 20, H-4010 Debrecen, Hungary.
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K
Gulácsi
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G
Litkei
S
S
Antus
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C
Szántay
L L
LL
Darkó
J
J
Szelényi
G
G
Haskó
S E
SE
Vizi
D000818:Animals; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001578:Benzopyrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D000440:Butanols / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D001555:Benzene Derivatives; D001578:Benzopyrans; D000440:Butanols; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha