Biochemical assessment of iodine deficiency disorders in Baroda and Dang districts of Gujarat State.
OBJECTIVE
(i) To assess the severity of Iodine Deficiency Disorders (DD) in Baroda and Dang Districts of Gujarat, using biochemical prevalence indicators of IDD; and (ii) To establish a biochemical baseline, in a sub-sample of the large population of Gujarat, that could be used to monitor the effectiveness of iodine replacement program.


METHODS
1,363 children (<1-15 years) were studied and data was collected on dietary habits, anthropometric and biochemical parameters such as height, weight and urinary iodine (UI) and blood TSH respectively. BSA and BMI were calculated. Drinking water and salt were analyzed for iodine content.


RESULTS
Median true urinary iodine was 65 microg/I (interquartile-range 38-108). Mean TSH was 2.08 mU/1 (SD +/- 2.06) and 6% of the studied population had whole blood TSH values > 5 mU/1. Females from both districts were affected more by iodine deficiency as evidenced by lower true urinary iodine and higher mean TSH levels. The interfering substances were significantly higher in Baroda boys and Dang girls as compared to their counterparts (< 0.001). Boys were more malnourished than girls as evidenced by lower BMI. Dang district was more severely affected by IDD as compared to Baroda. Drinking water in Dang district was lacking in iodine content. Iodine in salt varied at around 7 to 2000 PPM.


CONCLUSIONS
IDD is a public health problem in Gujarat. Baroda district is a new pocket of IDD. Dang district is the worse affected. The expression of IDD in these two districts of Gujarat revealed interplay of multiple factors.
Department of Diabetes and Endocrinology, Westmead Hospital, Westmead, NSW 2145, Australia. sheelab@westgate.wh.usyd.edu.au
S R
SR
Brahmbhatt
R A
RA
Fearnley
R M
RM
Brahmbhatt
C J
CJ
Eastman
S G
SG
Boyages
D000293:Adolescent; D017677:Age Distribution; D000886:Anthropometry; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D003409:Congenital Hypothyroidism / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D006043:Goiter, Endemic / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007194:India / Q000453:epidemiology; D007223:Infant; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D016014:Linear Models; D008297:Male; D011336:Probability; D012307:Risk Factors; D012424:Rural Population; D012494:Sampling Studies; D017678:Sex Distribution; D013972:Thyrotropin / Q000032:analysis
D013972:Thyrotropin; D007455:Iodine