The spectrum of chronic autoimmune hepatitis.
Autoimmune hepatitis (AIH) is characterised by the presence of periportal hepatitis coupled with the presence of autoantibodies in the serum. We report our experience with 10 cases (females--8, males--2) who presented to the rheumatology clinic with either articular or extra-articular manifestations. Three patients (1 SLE, 1 Sjogren's and 1 RA), satisfied the criteria for an underlying rheumatic disease (secondary AIH) while, others had primary AIH. Median duration of hepatic involvement was 6 months and the varied presentations were noted. Articular disease ranged from arthralgias, palindromic arthritis to persistent non-erosive/non-deforming arthritis (Jaccoud's arthritis). Autoimmune thrombocytopenia was seen in 2 and autoimmune hypo and hyperthyroidism were seen in 3 patients each. Anti-nuclear antibody was positive in 9/10 (6 with speckled pattern and 3 with homogenous pattern) and anti-mitochondrial antibodies were positive in three. Hepatitis C virus (HCV) markers were positive in 1, who probably had viral hepatitis with dominant autoimmune features. All have been started on steroids (5 patients--1 mg/kg dose, 1 patient--0.5 mg/kg dose and 3 patients--0.25 mg/kg dose). The HCV positive patient was on a low dose steroid (0.25 mg/kg) and interferron treatment was contemplated before she was lost to follow up. Four patients are also on azathioprine in the dose of 2 mg/kg/day. Of the 6 patients who are under regular follow up, the liver parameters have normalised in 5 and one showed hypoalbuminaemia with normal enzyme levels at the last follow up.
Division of Rheumatology, PD Hinduja National Hospital and Medical Research Centre, Mumbai.
C
C
Balakrishnan
G
G
Mangat
S
S
Kalke
D
D
Desai
A
A
Joshi
R B
RB
Deshpande
V R
VR
Joshi
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001379:Azathioprine / Q000008:administration & dosage; D001707:Biopsy, Needle; D002908:Chronic Disease; D005260:Female; D006508:Hepatitis Antibodies / Q000097:blood; D019693:Hepatitis, Autoimmune / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage; D011379:Prognosis; D011446:Prospective Studies; D012216:Rheumatic Diseases / Q000150:complications* / Q000175:diagnosis* / Q000188:drug therapy; D012720:Severity of Illness Index; D016896:Treatment Outcome
D001323:Autoantibodies; D006508:Hepatitis Antibodies; D011239:Prednisolone; D001379:Azathioprine