Effects of an onion-olive oil maceration product containing essential ingredients of the Mediterranean diet on blood pressure and blood fluidity.
Twenty-four patients with arterial hypertension (WHO class I) received either 4 capsules of an onion-olive oil maceration product, containing essential ingredients of the Mediterranean diet, or placebo daily over a period of one week. In order to investigate the acute effect on arterial blood pressure, measurements were performed before and 5 h after the administration of the first dose of 4 capsules verum or placebo, respectively. For the evaluation of the long term effect further blood pressure measurements were performed after one week's treatment with a daily dose of 4 capsules. After a wash-out phase of 2 weeks followed by a crossover, the second study phase, which was identical in design, was carried out. In addition patients were instructed to measure their blood pressure 4 times daily at home for the whole study period. Haemorheological parameters (platelet aggregation, erythrocyte aggregation, plasma viscosity and haematocrit) were also determined at the measuring points mentioned above. The onion-olive oil maceration product led to a significant decrease in systolic blood pressure. There was also a trend towards a decrease in diastolic blood pressure. The improved blood fluidity observed resulted from a decrease in haematocrit. All effects could be shown immediately and after one week's administration.
Medizinische Fakultät, Humboldt Universität zu Berlin, Institut für Transfusionsmedizin, Universitätsklinikum Charité, Berlin, Germany.
B
B
Mayer
U
U
Kalus
A
A
Grigorov
G
G
Pindur
F
F
Jung
H
H
Radtke
K
K
Bachmann
C
C
Mrowietz
J
J
Koscielny
E
E
Wenzel
H
H
Kiesewetter
D000328:Adult; D001769:Blood / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D019083:Mediterranean Region; D000069463:Olive Oil; D019697:Onions / Q000737:chemistry*; D010938:Plant Oils / Q000009:adverse effects / Q000737:chemistry / Q000627:therapeutic use*; D012212:Rheology
D000069463:Olive Oil; D010938:Plant Oils