[Recurrent coumarin necrosis in type II protein S deficiency].
Coumarin necrosis is a rare but clinical very important complication of therapy with coumarin derivatives. We report a patient with congenital protein S deficiency type II, who developed coumarin necrosis during stabilization of phenprocoumon. Diagnostic problems and therapeutic alternatives are discussed considering the recent literature.
Medizinische Klinik und Poliklinik I, Universität Leipzig und Innere Abteilung des evangelisch-lutherischen Diakonissenkrankenhauses zu Leipzig.
H J
HJ
Seyfarth
A
A
Siegemund
L
L
Helling
M
M
Woinke
D
D
Pfeiffer
C
C
Rühlmann
D000328:Adult; D003937:Diagnosis, Differential; D006579:Heterozygote; D006801:Humans; D008297:Male; D009336:Necrosis; D010644:Phenprocoumon / Q000008:administration & dosage / Q000009:adverse effects*; D018455:Protein S Deficiency / Q000175:diagnosis / Q000235:genetics*; D012867:Skin / Q000473:pathology*; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000175:diagnosis
D010644:Phenprocoumon