Advances in human cardiac 31P-MR spectroscopy: SLOOP and clinical applications.
Phosphorus magnetic resonance spectroscopy (31P-MRS) has revealed a lot about the biochemistry of physiological and pathological processes in the heart. Nevertheless, until today, cardiac 31P-MRS has not had any clinical impact, albeit some pioneering studies demonstrated that 31P-MRS can indeed provide diagnostic information. In this paper, the development of techniques for human cardiac 31P-MRS over the past decade is reviewed, and the requirements for a reliable clinical measurement protocol are discussed. Spatial localization with optimal pointspread function (SLOOP) is a new method to achieve spatial localization and absolute quantitation. Its properties are detailed, and preliminary findings in patients with dilated cardiomyopathy or myocardial infarction are presented.
Institute of Physics, University of Würzburg, Am Hubland, Würzburg, Germany. markus_f_m.von_kienlin@roche.com
M
M
von Kienlin
M
M
Beer
A
A
Greiser
D
D
Hahn
K
K
Harre
H
H
Köstler
W
W
Landschütz
T
T
Pabst
J
J
Sandstede
S
S
Neubauer
D006331:Heart Diseases / Q000175:diagnosis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D010759:Phosphorus Isotopes
D010759:Phosphorus Isotopes