Influence of butyric and lactic acids on the beta-glucuronidase activity of Clostridium perfringens.
The beta-glucuronidase activity of intact cells of Clostridium perfringens was not influenced by the presence of either 0.09 or 0.19% lactic or butyric acids. In contrast, the enhanced enzyme activity of intact cells due to sodium deoxycholate was significantly decreased by the presence of these acids. These results suggest the possibility that the development of cancer due to the intake of a high fat diet may be inhibited by the presence of organic acids produced by intestinal bacteria.
Kanagawa Prefectural Public Health Laboratory, Yokohama, Japan.
T
T
Fujisawa
K
K
Aikawa
T
T
Takahashi
S
S
Yamai
K
K
Watanabe
Y
Y
Kubota
M
M
Miyaoka
D020148:Butyric Acid / Q000494:pharmacology*; D003016:Clostridium perfringens / Q000187:drug effects* / Q000201:enzymology / Q000302:isolation & purification; D005243:Feces / Q000382:microbiology; D005966:Glucuronidase / Q000378:metabolism*; D006801:Humans; D007422:Intestines / Q000382:microbiology; D019344:Lactic Acid / Q000494:pharmacology*
D020148:Butyric Acid; D019344:Lactic Acid; D005966:Glucuronidase