Pharmacological effects of elenoside, an arylnaphthalene lignan.
Acute toxicity (24 h) and general behavior in mice of a lignan from Justicia hyssopifolia, a beta-D-glucoside (elenoside), was studied, and the cytotoxic activity was performed. Elenoside (arylnaphthalene lignan) in mice showed a moderate toxicity order (305 mg/kg) and central depressive properties at doses of 25, 50, and 100 mg/kg. It also displayed cytotoxic activity in a range of concentration of 10(-5)-10(-4) M when studied in the human tumor cell line panel of the US National Cancer Institute (NCI). The results indicated that elenoside has central depressant effects, and the cytotoxic activity of elenoside suggests that this compound and its genin derivatives merit further investigation as antitumoral drugs.
Department of Pharmacology, Faculty of Medicine, University of La Laguna, Tenerife, Spain. enavarro@ull.es
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E
Navarro
S J
SJ
Alonso
P J
PJ
Alonso
J
J
Trujillo
E
E
Jorge
C
C
Perez
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007928:Lethal Dose 50; D017705:Lignans / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; C428195:elenoside