Enantioselectivity of 3-amino-2-oxazolidinone derivatives with potential psychotropic activity on cellulose tris(4-methylbenzoate) chiral selector.
The behavior of a series of 3-amino-2-oxazolidinone derivatives with a potential hypnotic activity on achiral (octadecylsilane) and chiral (cellulose tris(4-methylbenzoate)) stationary phases was examined. The compounds differed in the composition of a substituted aromatic ring containing different substituents in different positions. It was possible to resolve all the compounds with selectivity 1.11 < or = alpha < or = 2.74. The enantiodifferentiating power of substituents was correlated to their electron donating ability and position in the aromatic ring.
Drug Institute, ul. Chelmska 30/34, 00-725 Warsaw, Poland. chilmon@il.waw.pl
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Z
Chilmonczyk
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Ksycińska
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Krzywda
J
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Iskra-Jopa
D001565:Benzoates / Q000737:chemistry*; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D007700:Kinetics; D008996:Monoamine Oxidase Inhibitors / Q000737:chemistry / Q000494:pharmacology; D023303:Oxazolidinones / Q000737:chemistry* / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000737:chemistry* / Q000494:pharmacology; D013237:Stereoisomerism; D013379:Substrate Specificity
D001565:Benzoates; D008996:Monoamine Oxidase Inhibitors; D023303:Oxazolidinones; D011619:Psychotropic Drugs; C090722:tris(4-methylbenzoate)cellulose; C000209:3-amino-2-oxazolidinone; D002482:Cellulose