An efficient batch preparation of high specific activity.
The increasing demand for radiolabeled metaiodobenzylguanidine (mIBG) prompted the need to obtain the radiopharmaceutical by a reliable, routine and simple synthetic method for batch production. The production of mIBG labeled with either 123I or 124I has been optimized by modifying literature methods that involve solid-state exchange reaction on "cold" mIBG facilitated by ammonium sulfate. The radiochemical yield and purity of radioiodinated mIBG generally exceeded 80 and 98%, respectively, with specific activity of > 50 mCi/mg.
Amartey
J K
JK
Radionuclide & Cyclotron Operations Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. amarty@kfshrc.edu.sa
Al-Jammaz
I
I
Lambrecht
R M
RM
D019797:3-Iodobenzylguanidine / Q000138:chemical synthesis*; D000645:Ammonium Sulfate; D007202:Indicators and Reagents; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine; D000645:Ammonium Sulfate