Role of dysregulated apoptosis in atopic dermatitis.
Atopic dermatitis is a chronic inflammatory skin disease with a complex immune dysregulation and interplay of genetic, environmental and psychological factors. Activation and skin-selective homing of peripherial-blood T cells, and effector functions in the skin, represent sequential events in the pathogenesis. Dysregulated apoptosis in skin-homing T cells, eosinophils and keratinocytes contributes to the elicitation and persistence of atopic derrmatitis.
Swiss Institute of Allergy and Asthma Research, Davos, Switzerland.
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Trautmann
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Akdis
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Blaser
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Akdis
D000818:Animals; D017209:Apoptosis / Q000276:immunology / Q000502:physiology*; D003876:Dermatitis, Atopic / Q000276:immunology / Q000473:pathology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology