Intestinal permeability in strongyloidiasis.
The objective of the present study was to assess intestinal permeability in patients with infection caused by Strongyloides stercoralis. Twenty-six patients (16 women and 10 men), mean age 45.9, with a diagnosis of strongyloidiasis were evaluated. For comparison, 25 healthy volunteers (18 women and 7 men), mean age 44.9, without digestive disorders or intestinal parasites served as normal controls. Intestinal permeability was measured on the basis of urinary radioactivity levels during the 24 h following oral administration of chromium-labeled ethylenediaminetetraacetic acid ((51)Cr-EDTA) expressed as percentage of the ingested dose. The urinary excretion of (51)Cr-EDTA was significantly reduced in patients with strongyloidiasis compared to controls (1.60 +/- 0.74 and 3.10 +/- 1.40, respectively, P = 0.0001). Intestinal permeability is diminished in strongyloidiasis. Abnormalities in mucus secretion and intestinal motility and loss of macromolecules could explain the impaired intestinal permeability.
Laboratório de Investigação Médica (LIM 07), Departamento de Gastroenterologia, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.
A L
AL
Werneck-Silva
A M
AM
Sipahi
A O
AO
Damião
C A
CA
Buchpigue
K
K
Iriya
A A
AA
Laudanna
D000328:Adult; D000368:Aged; D000818:Animals; D016022:Case-Control Studies; D002860:Chromium Radioisotopes / Q000652:urine; D004492:Edetic Acid / Q000652:urine; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010539:Permeability; D017171:Strongyloides stercoralis; D013322:Strongyloidiasis / Q000503:physiopathology* / Q000652:urine
D002860:Chromium Radioisotopes; D004492:Edetic Acid