Identification of HLA-B*0722.
A novel polymorphism was identified in a B*07 allele. B*0722 possesses a unique nucleotide substitution at nucleotide 481. This polymorphism encodes an amino acid difference from aspartic acid in B*07021 to asparagine in B*0722. The functional significance of this polymorphism on peptide binding and/or T-cell recognition is unknown.
The Anthony Nolan Research Institute and Histocompatibility Laboratories, London, United Kingdom. little@rfhsm.ac.uk
A M
AM
Little
S T
ST
Cox
M A
MA
Hoddinott
H
H
Ogilvie
E M
EM
Bohan
G J
GJ
Mufti
J A
JA
Madrigal
D015235:HLA-B Antigens / Q000235:genetics*; D015793:HLA-B7 Antigen; D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology; D020641:Polymorphism, Single Nucleotide
D015235:HLA-B Antigens; C425023:HLA-B*07 antigen; D015793:HLA-B7 Antigen