[Cochlear and retrocochlear deafness induced by immunity with different inner ear tissue antigens].
OBJECTIVE
To inquire into whether the different inner ear tissue antigens could cause different kind of hearing loss, and to find out the disorder positions of auditory system.


METHODS
The basilar membrane (BM), spiral ligament (SL), and spiral ganglion (SG) of guinea pigs were removed for making antigens, respectively. Then, we used these antigens to immune guinea pigs. The special humour and cellular immune reaction, hearing function, and inner ear histopathological changes were observed.


RESULTS
In BM-antigen and SL-antigen immune group, the various degrees of cochlear microphonic potential disturbance, recruitment, and immune pathological inflammation in cochlear duct and stria vascularis were found. In SG-antigen immune group, auditory nerve compound action potential changes were prominent, and the inner ear pathological damage mainly existed in cochlear axis vessels or surround areas, and SG.


CONCLUSIONS
It was confirmed that the inner ear antigens come from different part of auditory system, which could cause cochlear or retrocochlear autoimmune disease.
Department of Otolaryngology, Affiliated Hospital of Nanjing Railway Medical College, Nanjing 210009.
C
C
Tan
Y
Y
Cao
H
H
Liu
D000818:Animals; D001323:Autoantibodies; D001327:Autoimmune Diseases / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D001489:Basilar Membrane / Q000276:immunology; D003053:Cochlear Duct / Q000648:ultrastructure; D003055:Cochlear Microphonic Potentials; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D013136:Spiral Ganglion / Q000276:immunology; D013316:Stria Vascularis / Q000648:ultrastructure
D001323:Autoantibodies