[Diagnosis and treatment of endodermal sinus tumor of the vagina].
OBJECTIVE
To describe the clinical characteristics and the role of chemotherapy in endodermal sinus tumor of the vagina.


METHODS
Two patients with endodermal sinus tumor of the vagina were presented focusing on the clinical manifestations and outcome of the chemotherapy.


RESULTS
Patient's age was quite young, 2 and 3 years old respectively. Vaginal bleeding and a polypoid and fragile tumor of the vagina were main clinical features. Elevated serum alpha-FP was found before chemotherapy and dropped dramatically to normal if the tumor was sensitive to chemotherapy. Diagnosis was made by pathology and alpha-FP immunohistochemical staining. Both two patient was well responded to cisplatin vincristine bleomycin (PVB) and cisplatin etoposide bleomycin (PEB) chemotherapy. Clinical and pathological complete remission was obtained after 2-3 courses of chemotherapy without radical surgery and radiotherapy.


CONCLUSIONS
Endodermal sinus tumor of vagina in infant was very sensitive to the chemotherapy. Serum alpha-FP was very useful in diagnosis and monitoring of the disease.
Shen
K
K
Chinese Academy of Medical Science, Peking Union Medical College, Peking Union Medical College Hospital, Beijing 100730.
Huang
R
R
Lang
J
J
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002675:Child, Preschool; D002945:Cisplatin / Q000008:administration & dosage; D018240:Endodermal Sinus Tumor / Q000175:diagnosis / Q000188:drug therapy*; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D014625:Vaginal Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D014747:Vinblastine / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000096:biosynthesis
D000509:alpha-Fetoproteins; D001761:Bleomycin; D014747:Vinblastine; D005047:Etoposide; D002945:Cisplatin