Hipposulfates A and B, new sesterterpene sulfates from an Okinawan sponge, Hippospongia cf. metachromia.
Two new sesterterpene sulfates, hipposulfates A (1) and B (2), have been isolated from an Okinawan sponge, Hippospongia cf. metachromia and their structures elucidated by interpretation of spectroscopic data. Both compounds contain an enolsulfate functionality. Hipposulfate A (1) showed moderate cytotoxicity.
Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, Okinawa 903-0213, Japan.
M
M
Musman
I I
II
Ohtani
D
D
Nagaoka
J
J
Tanaka
T
T
Higa
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D019073:HT29 Cells; D006801:Humans; D007941:Leukemia P388; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D054830:Sesterterpenes; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D054830:Sesterterpenes; D013729:Terpenes; C428584:hipposulfate A; C428583:hipposulfate B