Anti-dopamine antibodies: effects on behavior in an "open field," pain sensitivity, CNS monoamine content, and functional activity of immunocytes in C57Bl/6 mice.
Single i.p. doses of anti-dopamine antibodies were given to C57Bl/6 mice. This resulted in inhibition of motor activity in a large proportion of the animals in the "open field" test, which lasted five days. Hyperalgesia, detected 1.5 h and 1 day after doses of antibody, was replaced by analgesia on day 5. There was a sharp reduction in the levels of dopamine and its metabolites in the cerebral cortex at 1 and 5 days; the serotonin level was increased 1 day after doses of antibody, and was significantly decreased at 5 days. There was no effect on cells of the immune system. The possible mechanisms of the neurotropic action of these antibodies are discussed.
Trekova
N A
NA
Science Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
Vetrilé
L A
LA
Basharova
L A
LA
Mikovskaya
O I
OI
Khlopushina
T G
TG
D000818:Animals; D019138:Antibodies, Blocking / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D015306:Biogenic Monoamines / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000276:immunology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000523:psychology*; D010147:Pain Measurement / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D019138:Antibodies, Blocking; D015306:Biogenic Monoamines; D004298:Dopamine