Transcranial magnetic stimulation in an amphetamine hyperactivity model of mania.
OBJECTIVE
Transcranial magnetic stimulation (TMS) of the brain has been reported to have therapeutic effects in mania, as well as depression. TMS has previously been reported to have effects similar to those of electroconvulsive shock in rat models of depression.


METHODS
We, therefore, studied TMS in amphetamine-induced hyperactivity as a rat model of mania.


RESULTS
While two and seven daily TMS sessions significantly reduced activity after amphetamine, twice-daily TMS for 7 days enhanced activity after amphetamine.


CONCLUSIONS
The results suggest that TMS treatment to rats interacts with the effects of amphetamine; the specific effects may be dependent on the schedule of treatment.
Stanley Center for Bipolar Research, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer-Sheba, Israel.
A
A
Shaldivin
A
A
Kaptsan
R H
RH
Belmaker
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H
Einat
N
N
Grisaru
D000661:Amphetamine / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001714:Bipolar Disorder / Q000175:diagnosis / Q000628:therapy*; D004195:Disease Models, Animal; D055590:Electromagnetic Phenomena / Q000379:methods*; D006948:Hyperkinesis / Q000139:chemically induced*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012886:Skull
D000661:Amphetamine