Lower urinary tract symptoms suggestive of benign prostatic obstruction--Triumph: the role of general practice databases.
The Triumph project aims to document the current management of lower urinary tract symptoms (LUTS) suggestive of benign prostatic hyperplasia (BPH) in general practice and to assess the effectiveness of the initial treatment options used. The first phase of the project will consider existing data sources in primary care. A patient's medical record will contain most, if not all, clinically relevant information, and databases combining the records from a network of computerised general practices can provide longitudinal data for complete populations, linking prescribing records to clinical information on disease progression and outcomes for individual patients. Database research can provide rapid information and offers the ability to conduct studies on a scale that would previously have been prohibited by both time and expense. Within the Triumph project, the THALES, General Practice Research Database (GPRD) and Integrated Primary Care Information (IPCI) databases are, or will be, used to examine the current management of LUTS/BPH in France, the UK and the Netherlands respectively. Preliminary results from the UK General Practice Research Database (GPRD) showed that LUTS/BPH incidence increased linearly from the ages of 45 to 85 years (r(2) = 0.992) and prevalence increased from 3.5% to 35% for men in their late 40s and 80s respectively. With treatment failure defined as a change to another medical therapy, catheterisation or prostatic surgery, and accounting for age and year variation, patients receiving the older alpha(1)-blockers (indoramin and prazosin) appeared to fail significantly earlier than those receiving finasteride. There was no significant difference between finasteride and the newer alpha(1)-blockers (tamsulosin, alfuzosin, terazosin and doxazosin). Patterns of changes between products from the THALES database in France were broadly similar to those seen in the UK.
Department of Pharmacoepidemiology and Public Health, Postgraduate Medical School, University of Surrey, Stirling Road, Surrey Research Park, Guildford GU2 7DJ, UK. r.farmer@surrey.ac.uk
J W
JW
Logie
G M
GM
Clifford
R D
RD
Farmer
B P
BP
Meesen
D016208:Databases, Factual; D005060:Europe; D005194:Family Practice; D006801:Humans; D008297:Male; D011320:Primary Health Care; D011470:Prostatic Hyperplasia / Q000150:complications* / Q000628:therapy*; D012106:Research; D014524:Urethral Obstruction / Q000209:etiology* / Q000628:therapy*