Solubility prediction of salmeterol xinafoate in water--dioxane mixtures.
The mole fraction solubility of salmeterol xinafoate was determined in various concentrations of dioxane in aqueous binary mixture. Maximum solubility was observed in 90% v/v dioxane and solubility parameter of the solute was estimated from solubility peak equal to 24.99 MPa(0.5). The predicting capability of four different cosolvency models was also evaluated employing a five data point training set. The solubility data at other cosolvent concentrations were predicted using the trained models, with percentage average errors for 28 drug solubility data sets in water-cosolvent mixtures lying between 12.5 and 15.0%. Further predictive model is proposed for accurate solubility predictions based on a minimum number of experiments. The percentage average error where tested was 10.6%.
Drug Design Group, School of Pharmacy, University of Bradford, Bradford BD7 1DP, UK. ghasem@pharm.usyd.edu.au
A
A
Jouyban-Gharamaleki
P
P
York
M
M
Hanna
B J
BJ
Clark
D000420:Albuterol / Q000031:analogs & derivatives* / Q000737:chemistry*; D001993:Bronchodilator Agents / Q000737:chemistry*; D004146:Dioxanes; D008956:Models, Chemical; D011237:Predictive Value of Tests; D000068299:Salmeterol Xinafoate; D012995:Solubility; D012997:Solvents; D014867:Water
D001993:Bronchodilator Agents; D004146:Dioxanes; D012997:Solvents; D014867:Water; D000068299:Salmeterol Xinafoate; C025223:1,4-dioxane; D000420:Albuterol