Immunoglobulin D multiple myeloma in our hospital--a rare occurrence.
Immunoglobulin (Ig) D multiple myeloma is a rare presentation, usually with an aggressive course and a poorer prognosis. It accounts for about 1-2% of newly diagnosed mulitple myeloma patients. Due to its rarity, reports on Ig D multiple myeloma are limited in the literature. We therefore present 4 cases of Ig D multiple myeloma in our hospital over a period of 8 years between 1990 to 1998. The average age of presentation of our patients was 44 years old with a female preponderance. Common presenting symptoms were appetite and weight loss and bone pain. Two patients presented with neurological symptoms and 2 with renal impairment. Three patients had an associated lambda paraproteinaemia and the fourth had a kappa paraproteinaemia. A common finding in Ig D myeloma is a small or no spike seen on serum electrophoresis together with heavy Bence Jones proteinuria. A review of the literature on Ig D myeloma is also presented.
Department of Laboratory Medicine, National University Hospital, Singapore.
L K
LK
Tan
R
R
Suri
H L
HL
Lim
S K
SK
Ong
D000328:Adult; D000368:Aged; D004586:Electrophoresis; D005260:Female; D006801:Humans; D007072:Immunoglobulin D; D008297:Male; D009101:Multiple Myeloma / Q000175:diagnosis / Q000276:immunology* / Q000628:therapy
D007072:Immunoglobulin D