[Advanced gastric adenocarcinoma with RER+ phenotype presents a good prognosis after 5 years of curative resection].
Microsatellite instability (MIN) has been found both in advanced and early gastric cancer. To find out the step played by MSI in gastric carcinogenesis, links between RER+ phenotype and clinical and pathological aspects have been studied. In this work our purpose is to analyze the relationship between MIN+ advanced gastric cancer and prognosis at 5 years after radical surgery. We investigated 34 patients affected by gastric cancer who underwent R0 surgical resection from February 1991 to October 1994. After that, they underwent a four-monthly follow-up for a minimum of 5 years. Genetic abnormalities have been searched including (a) those occurring in common-type CIN carcinomas and (b) those characteristic of MIN cancers. DNA extraction showed the presence of microsatellite instability (MIN) in 9 (26%) of the samples (vs. 74% of chromosomal instability CIN); none of them was M+ (vs. 12% of CIN cancers). Recurrence occurred in 2 out of 9 of the MIN cancers (22%) and in 21 out of 25 CIN cancers (84%). In conclusion, our data suggest that advanced gastric cancers with mutator phenotype show a better outcome at 5 years than the CIN phenotype.
Istituto di Semeiotica Chirurgica, Università degli Studi di Verona.
G
G
de Manzoni
A
A
di Leo
A
A
Castelli
A
A
Tomezzoli
S
S
Tasselli
C
C
Pedrazzani
M
M
Bonfiglio
A
A
Scarpa
D033942:Adaptor Proteins, Vesicular Transport; D000230:Adenocarcinoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002875:Chromosomes / Q000235:genetics; D004276:DNA, Satellite; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D008875:Middle Aged; D009367:Neoplasm Staging; D010641:Phenotype; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D013997:Time Factors
D033942:Adaptor Proteins, Vesicular Transport; D004276:DNA, Satellite; D008562:Membrane Glycoproteins; C109546:RER1 protein, human