Notes from the SNP vs. haplotype front.
Single nucleotide polymorphisms (SNPs) and haplotypes are commonly used genetic markers in clinical studies. We provide some broad guidelines for deciding which of the two is most appropriate in particular circumstances. Molecular haplotyping techniques are also briefly reviewed and contrasted with electronic approaches.
Judson
R
R
Genaissance Pharmaceuticals, 5 Science Park, New Haven, CT 06511, USA. r.judson@genaissance.com
Stephens
J C
JC
D005819:Genetic Markers; D014644:Genetic Variation; D015894:Genome, Human; D006239:Haplotypes; D020180:Heteroduplex Analysis; D006801:Humans; D015810:Linkage Disequilibrium; D010597:Pharmacogenetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D017422:Sequence Analysis, DNA
D005819:Genetic Markers