Blocking the receptor for interleukin 10 protects mice from lethal listeriosis.
High doses of Listeria monocytogenes overcome the ability of a normal mouse to control the infection, due to massive bacterial replication. Treatment with an anti-interleukin 10 (IL-10) receptor monoclonal antibody prevented the fatal course of infection with high doses of bacteria. This work shows that blocking the receptor for IL-10 may have useful therapeutic applications.
Laboratory of Microbiology and Immunology of Infection, Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
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Silva
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Appelberg
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D008088:Listeriosis / Q000382:microbiology / Q000473:pathology / Q000517:prevention & control*; D008099:Liver / Q000382:microbiology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D018123:Receptors, Interleukin / Q000037:antagonists & inhibitors*; D053701:Receptors, Interleukin-10
D000911:Antibodies, Monoclonal; D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10