Induction of T-cell apoptosis by polyurethane biomaterials used in left ventricular assist devices is dependent on calcineurin activation.
College of Physicians and Surgeons of Columbia University, New York, New York, USA.
M
M
Schuster
J
J
Ankersmit
A
A
Kocher
K
K
Lietz
N
N
Schuster
M
M
Hofmann
R
R
John
N
N
Edwards
M
M
Oz
S
S
Itescu
D017209:Apoptosis / Q000502:physiology*; D001672:Biocompatible Materials; D019703:Calcineurin / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D016572:Cyclosporine / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000378:metabolism; D006353:Heart-Assist Devices; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D011140:Polyurethanes / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000502:physiology; D014157:Transcription Factors / Q000378:metabolism
D001672:Biocompatible Materials; D004268:DNA-Binding Proteins; D007166:Immunosuppressive Agents; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D011140:Polyurethanes; D014157:Transcription Factors; D016572:Cyclosporine; D019703:Calcineurin