[New approach to correction of ventricular septal defects complicated by critical pulmonary hypertension].
The authors have studied the effect of preoperative administration of Vazaprostan-20 into the pulmonary artery of patients with a defect of the interventricular septum (DIVS) and high pulmonary hypertension. By the end of the second day the patients examined had lower pressure in the pulmonary artery from 18% to 38%, higher intracardiac output in patients with the III A and III B degrees of pulmonary hypertension. In all the patients plasty of the DIVS was fulfilled under conditions of hypothermal extracorporeal circulation. The degree of residual pulmonary hypertension in the group under study was 42% at an average, and in the control group it was 50%. The preoperative administration of Vazaprostan-20 decreased the operative risk and facilitated the postoperative period. It allowed to make operations on the wider group of patients whose possibility to be operated on was doubtful. The patients of the group under study were discharged from the hospital in a satisfactory state.
I V
IV
Shchelokov
G A
GA
Korolev
A B
AB
Korolev
V V
VV
Pichugin
D000293:Adolescent; D000527:Alprostadil / Q000008:administration & dosage*; D002302:Cardiac Output; D002648:Child; D002675:Child, Preschool; D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D011300:Preoperative Care; D012307:Risk Factors; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D000527:Alprostadil