Amelioration of cytotoxic effects of aflatoxin by vitamin A: an in vitro study on erythrocytes.
We have evaluated the ameliorative role of vitamin A on aflatoxin-induced cytotoxicity in vitro. Aflatoxin (1.95 microM)-induced hemolysis was found to be significantly reduced on addition of vitamin A (125--1250 IU/ml) in incubation medium. The decrease in hemolysis was almost dose dependent. The kinetics of reduction of AFB(1) to B(2) and AFG(1) to G(2) by vitamin A has been investigated in dilute aqueous solution at 37 degrees C. The rate of the reduction was found to be first order with respect to the concentration of vitamin A and aflatoxin concentration.
Department of Zoology, University School of Sciences, Gujarat University, Ahmedabad 380 009, India. zooldeptgu@satyam.net.in
R J
RJ
Verma
R S
RS
Shukla
D N
DN
Mehta
D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects* / Q000502:physiology; D006461:Hemolysis / Q000187:drug effects; D011817:Rabbits; D014801:Vitamin A / Q000494:pharmacology*
D000348:Aflatoxins; D014801:Vitamin A