Secrets of actin-based motility revealed by a bacterial pathogen.
Actin-based cell motility is a complex process involving a dynamic, self-organizing cellular system. Experimental problems initially limited our understanding of this type of motility, but the use of a model system derived from a bacterial pathogen has led to a breakthrough. Now, all the molecular components necessary for dynamic actin self-organization and motility have been identified, setting the stage for future mechanistic studies.
Cameron
L A
LA
Department of Biochemistry, Stanford University School of Medicine, 279 Campus Drive West, Stanford, California 94305-5307, USA.
Giardini
P A
PA
Soo
F S
FS
Theriot
J A
JA
D000199:Actins / Q000502:physiology*; D000818:Animals; D001419:Bacteria / Q000472:pathogenicity; D018407:Bacterial Physiological Phenomena; D002465:Cell Movement / Q000502:physiology*; D006801:Humans; D008089:Listeria monocytogenes / Q000502:physiology; D008954:Models, Biological; D009068:Movement / Q000502:physiology*
D000199:Actins