Platinum(II) and palladium(II) complexes with 2-acetylpyridine thiosemicarbazone: cytogenetic and antineoplastic effects.
The effect of three novel complexes of Pt(II) and three complexes of Pd(II) with 2-acetylpyridine thiosemicarbazone (HAcTsc) on sister chromatid exchange (SCE) rates and human lymphocyte proliferation kinetics on a molar basis was studied. Also, the effect of Pt(II) and Pd(II) complexes against leukemia P388 was investigated. Among these compounds, the most effective in inducing antitumor and cytogenetic effects were the complexes [Pt(AcTsc)2] x H2O and [Pd(AcTsc)2] while the rest, i.e. (HAcTsc), [Pt(AcTsc)Cl], [Pt(HAcTsc)2]Cl2 x 2H2O, [Pd(AcTsc)Cl] and [Pd(HAcTsc)2]Cl2, displayed marginal cytogenetic and antitumor effects.
Laboratory of Medicinal Biology and Genetics, Faculty of Medicine, Aristotle University of Thessaloniki, Greece.
Z
Z
Lakovidou
A
A
Papageorgiou
M A
MA
Demertzis
E
E
Mioglou
D
D
Mourelatos
A
A
Kotsis
P N
PN
Yadav
D
D
Kovala-Demertzi
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; D010165:Palladium / Q000494:pharmacology*; D010984:Platinum / Q000494:pharmacology*; D012854:Sister Chromatid Exchange; D013882:Thiosemicarbazones / Q000494:pharmacology*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D009944:Organoplatinum Compounds; D013882:Thiosemicarbazones; C426484:palladiium(II)(2-acetylpyridine thiosemicarbazone); C426485:platinum(II)(2-acetylpyridine thiosemicarbazone); D010984:Platinum; D010165:Palladium; C033836:2-acetylpyridine thiosemicarbazone