Recurrent cleft lip and palate in siblings of a patient with malabsorption syndrome, probably caused by hypovitaminosis a associated with folic acid and vitamin B(2) deficiencies.
We present a woman with metabolic disorders secondary to malabsorption and renal disease who gave birth to a stillborn male fetus with left unilateral cleft lip and palate and a live born infant with left unilateral cleft lip and palate. We discuss potential cofactors that could be implicated in the abnormal embryonic process.
Faron
G
G
Department of Obstetrics, Centre Hospitalier Universitaire de Québec (CHUQ), Université Laval, Québec, Québec, Canada. gilles.faron@chu-brugman.bc
Drouin
R
R
Pedneault
L
L
Poulin
L D
LD
Laframboise
R
R
Garrido-Russo
M
M
Fraser
W D
WD
D000328:Adult; D002971:Cleft Lip / Q000209:etiology*; D002972:Cleft Palate / Q000209:etiology*; D005260:Female; D005494:Folic Acid Deficiency / Q000150:complications*; D006801:Humans; D007223:Infant; D008286:Malabsorption Syndromes / Q000150:complications*; D008297:Male; D012008:Recurrence; D012257:Riboflavin Deficiency / Q000150:complications*; D014802:Vitamin A Deficiency / Q000150:complications*