Effect of dentifrice containing fluoride and/or baking soda on enamel demineralization/remineralization: an in situ study.
The additive effect of baking soda on the anticariogenic effect of fluoride dentifrice is not well established. To evaluate it, a crossover in situ study was done in three phases of 28 days. Volunteers, using acrylic palatal appliances containing four human enamel blocks, two sound (to evaluate demineralization) and two with artificial caries lesions (to evaluate remineralization), took part in this study. During each phase, 10% sucrose solution was dripped (3 times a day) only onto the sound blocks. After 10 min, a slurry of placebo, fluoride (F) or fluoride and baking soda (F+NaHCO(3)) dentifrice was dripped onto all enamel blocks. The results showed a higher F concentration in dental plaque formed during treatment with F+NaHCO(3) than placebo (p<0.05), but the difference related to F dentifrice was not significant. The enamel demineralization was lower, and remineralization was greater, after treatment with F+NaHCO(3) than placebo (p<0.05), but the difference related to F dentifrice was not significant. The data suggest that baking soda neither improves nor impairs the effect of F dentifrice on reduction of demineralization and enhancement of remineralization of enamel.
Faculty of Dentistry of Piracicaba, State University of Campinas, S.P., Brazil. jcury@unicamp.br
J A
JA
Cury
L N
LN
Hashizume
A A
AA
Del Bel Cury
C P
CP
Tabchoury
D002021:Buffers; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003743:Dental Enamel / Q000187:drug effects*; D003773:Dental Plaque / Q000378:metabolism; D003802:Dentifrices / Q000627:therapeutic use*; D004357:Drug Synergism; D005459:Fluorides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006244:Hardness; D006801:Humans; D010919:Placebos; D016037:Single-Blind Method; D017693:Sodium Bicarbonate / Q000008:administration & dosage / Q000627:therapeutic use*; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D013395:Sucrose / Q000494:pharmacology; D017001:Tooth Demineralization / Q000517:prevention & control*; D014089:Tooth Remineralization
D002021:Buffers; D002327:Cariostatic Agents; D003802:Dentifrices; D010919:Placebos; D013395:Sucrose; D017693:Sodium Bicarbonate; D005459:Fluorides