Effects of Shilajit on the development of tolerance to morphine in mice.
Effects of concomitant administration of Processed Shilajit (PS, 0.1 and 1 mg/kg, i.p.), in Swiss mice were evaluated on the development of tolerance to morphine induced analgesia in the hot plate test. Chronic administration of morphine (10 mg/kg, i.p., b.i.d.) to mice over a duration of 10 days resulted in the development of tolerance to the analgesic effect of morphine. Concomitant administration of PS with morphine, from day 6 to day 10, resulted in a significant inhibition of the development of tolerance to morphine (10 mg/kg, i.p.) induced analgesia. Processed Shilajit per se, in the doses used, did not elicit any significant analgesia in mice; nor did the chronic concomitant administration of Processed Shilajit alter the morphine-induced analgesia. These findings with Processed Shilajit indicate its potential as a prospective modifier of analgesic tolerance to morphine.
Tiwari
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P
Faculty of Pharmacy and Medical Sciences, Post Box No. 232, Amman University, Amman 19328, Jordan. vndna@firstnet.com.jo
Ramarao
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P
Ghosal
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S
D000700:Analgesics / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D000818:Animals; D019540:Area Under Curve; D004357:Drug Synergism; D004361:Drug Tolerance; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine / Q000493:pharmacokinetics*; D010146:Pain / Q000517:prevention & control*; D010936:Plant Extracts / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D010946:Plants, Medicinal
D000700:Analgesics; D010936:Plant Extracts; D009020:Morphine