Indocyanine green anterior segment angiography for studying conjunctival vascular changes after trabeculectomy.
BACKGROUND
The aim of the study was to evaluate the use of indocyanine green (ICG) for angiography of the anterior segment to characterize conjunctival and episcleral vasculature changes after trabeculectomy.


METHODS
This was a prospective evaluation of anterior segment ICG angiography in 10 eyes of 10 patients undergoing trabeculectomy for the first time. Trabeculectomy was performed with intraoperative sponge application of 5-fluorouracil (5 cases) or mitomycin C (5 cases). Anterior segment ICG angiography was performed prior to surgery, then at 2 weeks and 2 months after surgery.


RESULTS
With ICG, the anterior segment vessels were well delineated, including deep episcleral veins, which have not been clearly shown in previous angiographic techniques. Late phases of the angiogram could also be studied. The vascular alterations after trabeculectomy noted included oss of vascularity over the bleb area and vascular anastomoses along the perimeter of the avascular bleb.


CONCLUSIONS
Angiography using ICG has potential as an investigative tool to study the conjunctival and episcleral vasculature changes after trabeculectomy.
Singapore National Eye Centre, National University of Singapore.
Z
Z
Alsagoff
P T
PT
Chew
C K
CK
Chee
J S
JS
Wong
T
T
Aung
D000328:Adult; D000368:Aged; D000869:Anterior Eye Segment / Q000098:blood supply*; D002199:Capillary Permeability; D003228:Conjunctiva / Q000098:blood supply*; D005260:Female; D005451:Fluorescein Angiography; D005472:Fluorouracil / Q000008:administration & dosage; D015812:Glaucoma, Angle-Closure / Q000175:diagnosis / Q000601:surgery; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D010865:Pilot Projects; D011446:Prospective Studies; D014130:Trabeculectomy; D016896:Treatment Outcome; D014680:Veins
D016685:Mitomycin; D007208:Indocyanine Green; D005472:Fluorouracil