New reagents for detection of faecal occult blood.
Imipramine hydrochloride (IPH) and desipramine hydrochloride (DPH), two widely used antidepressant drugs, are proposed as new reagents for detection of faecal occult blood. The usefulness of IPH and DPH in occult blood detection has been examined and compared with benzidine and stanoccult methods. The results show that the proposed reagents are selective and sensitive and gives reproducible results. The proposed methodology is much less subject to vegetable peroxidase, iron and vitamin C interference and can be performed on patients who are on a normal diet.
Syed
A A
AA
Department of Studies in Chemistry, University of Mysore, Manasagangotri, India. syedakheelahmed@hotmail.com
Khatoon
B A
BA
Silwadi
M F
MF
D000473:Alkanes; D003891:Desipramine; D004492:Edetic Acid; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007099:Imipramine; D007202:Indicators and Reagents; D008670:Metals; D009780:Occult Blood; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D000473:Alkanes; D007202:Indicators and Reagents; D008670:Metals; D004492:Edetic Acid; C004544:naphtha; D007099:Imipramine; D003891:Desipramine