Delayed adverse reaction to sodium ioxaglic acid-meglumine.
A patient had a maculopapular rash, fever, hepatic cytolysis, rhabdomyolysis, eosinophilia and raised total IgEs after coronarography with ioxaglic acid-meglumine (Hexabrix). Intradermal test to ioxaglic acid-meglumine was positive 48 hrs later. Histological examination revealed perivascular lymphocytic infiltration, with predominantly CD45Ro+ and CD8+ T cells and apoptotic basal keratinocytes. This case documents a late hypersensitivity reaction to ioxaglic acid-meglumine.
Service de Médecine D, Médecine Interne, Immunologie Clinique et Allergologie, CHU de Nancy, Hôpital Central, 29, avenue de Lattre-de-Tassigny, 54035 Nancy Cedex, France. g.kanny@chu-nancy.fr
G
G
Kanny
B
B
Marie
B
B
Hoen
P
P
Trechot
D A
DA
Moneret-Vautrin
D017130:Angioplasty / Q000009:adverse effects*; D003287:Contrast Media / Q000009:adverse effects*; D003875:Drug Eruptions / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced / Q000175:diagnosis* / Q000473:pathology; D007428:Intradermal Tests; D007485:Ioxaglic Acid / Q000009:adverse effects*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000601:surgery
D003287:Contrast Media; D007485:Ioxaglic Acid