[The effect of endothelium-derived relaxation factor on specific property of vasomotion of cochlea in guinea pig].
By using intravital microscopy measurement with image processing system, continuous diameter changes were measured by self-tracking with computer, the present study is to investigate specific property of vasomotion in cochlear microvessels and its responsibility to the endothelium-derived relaxation factor (EDRF/NO). The results demonstrated that the vasomotion of cochlear arteriole existed in normal condition in a small pattern. It was found that the vasomotion was significantly enhanced after administration of L-arginine(which is donor of EDRF/NO), and L-arginine induces a sequence of changes in cochlear blood flow. There were significant statistic difference before and after the drug administration. The conclusion suggest that EDRF/NO play an important role in the increase of blood flow by improvement of vasomotion.
Institute of Otolaryngology, PLA Jeneral Hospital, Beijing 100093.
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Shi
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Dong
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Jiang
D000818:Animals; D003051:Cochlea / Q000098:blood supply*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D009569:Nitric Oxide / Q000494:pharmacology*; D012039:Regional Blood Flow; D014661:Vasoconstriction / Q000187:drug effects
D009569:Nitric Oxide