Abnormal postexcitatory and interhemispheric motor cortex inhibition in writer's cramp.
Focal transcranial magnetic stimulation (TMS) of the motor cortex was used to study excitatory and inhibitory stimulation effects in 25 patients with writer's cramp and 25 healthy volunteers. We investigated excitatory and inhibitory corticospinally mediated motor effects in muscles contralateral to the stimulation side as well as interhemispheric inhibition of tonic motor activity in muscles ipsilateral to stimulation. Motor evoked potentials (MEPs) were recorded from both first dorsal interosseus muscles. Motor thresholds at rest and amplitudes and latencies of MEPs obtained during maximal contraction were always bilaterally normal. The duration of postexcitatory inhibition was significantly shortened (168+/-55 vs. 198+/-39 ms in normal subjects, P=0.001) and the duration of interhemispheric inhibition prolonged (30.3+/-6.6 vs. 26+/-3.9 ms in normal subjects, P < 0.001). Both observations would be compatible with a decreased inhibition of corticospinal and transcallosal outputs of the motor cortex. The results were not influenced by fatigue effects. Abnormal motor cortex inhibition seems to be a generalized phenomenon in writer's cramp since it was detected in both hemispheres and during a simple isometric motor task which did not evoke dystonic symptoms.
Department of Neurology Charité, Virchow Klinikum, Humboldt University, Berlin, Germany.
L
L
Niehaus
K
K
von Alt-Stutterheim
S
S
Röricht
B U
BU
Meyer
D000328:Adult; D000368:Aged; D003337:Corpus Callosum / Q000502:physiology*; D005260:Female; D007839:Functional Laterality; D006801:Humans; D008280:Magnetics; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000502:physiology*; D009120:Muscle Cramp / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D009435:Synaptic Transmission; D013647:Task Performance and Analysis; D014956:Writing