[Serum concentration of interleukin-6 in maternal serum and its expression in amniochorionic membranes of preterm premature rupture of membrane].
OBJECTIVE
To investigate the relationship between interleukin-6 (IL-6) and preterm premature rupture of membranes (PPROM).


METHODS
Serum IL-6 in 20 cases of normal pregnancy (control group) and 30 cases with PPROM in which 14 had moderate and severe chorioamnionitis (group 1), 16 had no chorioamnionitis (group 2) were measured by enzyme-linked immunosorbent assay (ELISA), and IL-6 protein in fetal membranes were determined by immunohistochemistry technique.


RESULTS
The level of serum IL-6 in group 1 (155.17 ng/L) was significantly higher than that in group 2 (79.11 ng/L) and control group (70.15 ng/L) (P < 0.01). Expression of the IL-6 had more positive signs in chorion with chorioamnionitis, especially in infiltrating inflammatory cells.


CONCLUSIONS
IL-6 associated with the onset of preterm labor caused by infection.
Third Hospital, Beijing Medical University, Beijing 100083.
Y
Y
Zhao
S
S
Li
X
X
Tong
D005321:Extraembryonic Membranes / Q000378:metabolism*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000097:blood*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D007752:Obstetric Labor, Premature / Q000097:blood*; D011247:Pregnancy
D015850:Interleukin-6