Voltage-gated K+ channels in chemoreceptor sensory neurons of rat petrosal ganglion.
A subpopulation of sensory neurons in the petrosal ganglion transmits information between peripheral chemoreceptors (glomus cells) in the carotid body and relay neurons in the nucleus of the solitary tract. Expression of voltage-gated K+ channels in these neurons was characterized by immunohistochemical localization. Five members of the Kv1 family, Kv1.1, Kv1.2, Kv1.4, Kv1.5 and Kv1.6 and members of two other families, Kv2.1 and Kv4.3, were identified in over 90% of the chemoreceptor neurons. Although the presence of these channel proteins was consistent throughout the population, individual neurons showed considerable variation in K+ current profiles.
Rammelkamp Center for Education and Research, MetroHealth Medical System and Department of Neurosciences, Case Western Reserve University, 2500 MetroHealth Drive, Cleveland, OH 44109-1998, USA.
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EM
Andrews
D L
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Kunze
D000818:Animals; D002344:Carotid Body / Q000737:chemistry* / Q000502:physiology; D051668:Delayed Rectifier Potassium Channels; D066298:In Vitro Techniques; D015640:Ion Channel Gating / Q000502:physiology; D051662:Kv1.1 Potassium Channel; D051663:Kv1.2 Potassium Channel; D051665:Kv1.4 Potassium Channel; D051666:Kv1.5 Potassium Channel; D008564:Membrane Potentials / Q000502:physiology; D009475:Neurons, Afferent / Q000737:chemistry* / Q000201:enzymology; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000032:analysis* / Q000502:physiology; D024642:Potassium Channels, Voltage-Gated; D051381:Rats; D017207:Rats, Sprague-Dawley; D051669:Shab Potassium Channels; D051672:Shal Potassium Channels; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D051668:Delayed Rectifier Potassium Channels; C496972:Kcna2 protein, rat; C496979:Kcna4 protein, rat; C496983:Kcna5 protein, rat; C496991:Kcnb1 protein, rat; C497023:Kcnd3 protein, rat; D051663:Kv1.2 Potassium Channel; D051665:Kv1.4 Potassium Channel; D051666:Kv1.5 Potassium Channel; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated; D051669:Shab Potassium Channels; D051672:Shal Potassium Channels; D051662:Kv1.1 Potassium Channel; D014446:Tyrosine 3-Monooxygenase