Platelet activation markers and soluble adhesion molecules in patients with systemic lupus erythematosus.
We assessed the role of platelet activation markers (PMPs, Annexin V and CD62P on activated platelets), cytokines (IL-1 beta, IL-4, IL-6, IFN- gamma, GM-CSF, and TNF alpha ), and soluble factors (sIL-2R, TM, sHLA-1, beta(2) -m, sVCAM-1, sPECAM-1, sP-selectin and sE-selectin) in vascular damage related to SLE. There were differences in the levels of PMPs and platelet activation markers between the SLE patients and controls (PMPs: 493+/-82 vs. 328+/-36, p<0.05; plt-CD62P; 8.5%+/-1.2 % vs. 4.6%+/-0.7 %, p<0.05; plt-Annexin V: 11.3%+/-2.1 % vs. 4.9%+/-0.6 %, p<0.01). There were no differences in the levels of IFN- gamma between the groups. However, the levels of IL-1 beta, IL-4, IL-6, GM-CSF, TNF alpha, and soluble factors were higher in the SLE patients than in the controls. The levels of IL-4, IL-6, beta2 -m, sIL-2R, sVCAM-1, sP-selectin, and sE-selectin in SLE patients with elevated sTM levels were higher than those in the SLE patients without elevated sTM levels. On the other hand, elevations of sIL-2R, sVCAM-1, and sP-selectin were not found in patients with Behçet disease or rheumatoid arthritis. The levels of platelet CD62P, platelet annexin V, and PMP were significantly elevated in high-sTM patients. These findings suggest the possibility that activated platelets and cytokines participate in the pathogenesis of SLE in patients with elevated sTM levels.
Nagahama
M
M
The First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
Nomura
S
S
Ozaki
Y
Y
Yoshimura
C
C
Kagawa
H
H
Fukuhara
S
S
D000328:Adult; D017304:Annexin A5 / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry* / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000097:blood* / Q000502:physiology; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D010316:Particle Size; D015539:Platelet Activation / Q000276:immunology*; D012995:Solubility; D018180:Thrombomodulin / Q000097:blood
D017304:Annexin A5; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines; D019007:P-Selectin; D018180:Thrombomodulin