[Induction of antimeningitis immunity by synthetic peptides. II. Immunoactive synthetic fragments of OpaB protein from Neisseria meningitidis].
Mice of various lines were immunized by 11 synthetic peptides that correspond to the sequences of fragments of the OpaB protein from the outer membrane of Neisseria meningitidis involving the known human T-helper epitopes and all the potential mouse T-helper epitopes calculated for the protein. The mice were immunized with the free peptides without their conjugation with a protein carrier. Most of the peptides were found to induce in mice the production of antipeptide antibodies. The mice protection against the experimental infection by a virulent strain of N. meningitidis of the B serotype was studied, and two peptides were shown to exert the most pronounced protective effect.
Koroev
D O
DO
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, ul. Miklukho-Maklaya 16/10, GSP-7 Moscow, 117871 Russia. koroev@mail.ibch.ru
Vol'pina
O M
OM
Zhmak
M N
MN
Kupriianova
M A
MA
Nesmeianov
V A
VA
Alliluev
A P
AP
Kotel'nikova
O V
OV
Ivanov
V T
VT
D000595:Amino Acid Sequence; D000818:Animals; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D007109:Immunity / Q000276:immunology*; D007114:Immunization; D016920:Meningitis, Bacterial / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology
D001425:Bacterial Outer Membrane Proteins; D010446:Peptide Fragments; C090348:Opa protein, Neisseria