Tie receptors: new modulators of angiogenic and lymphangiogenic responses.
Angiogenesis is required for normal embryonic vascular development and aberrant angiogenesis contributes to several diseases, including cancer, diabetes and tissue ischaemia. What are the molecular mechanisms that regulate this important process? The Tie family of receptors and their ligands, the angiopoietins, are beginning to provide insight into how vessels make decisions such as whether to grow or regress--processes that are important not only during development but throughout an organism's life.
Department of Medical Biophysics, University of Toronto, Sunnybrook and Women's College Health Sciences Centre, 2075 Bayview Avenue, S-227, Toronto, Ontario, Canada M4N 3M5.
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Dumont
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D000375:Aging / Q000502:physiology; D042683:Angiopoietin-1; D000818:Animals; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002465:Cell Movement; D002470:Cell Survival; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism / Q000473:pathology; D006133:Growth Substances / Q000502:physiology; D006410:Hematopoiesis; D006801:Humans; D000860:Hypoxia / Q000097:blood / Q000503:physiopathology; D008562:Membrane Glycoproteins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism*; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D011518:Proto-Oncogene Proteins; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism*; D042764:Receptors, TIE; D015398:Signal Transduction
D042683:Angiopoietin-1; D015815:Cell Adhesion Molecules; D006133:Growth Substances; C105373:MEN1 protein, human; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D020794:Receptor Protein-Tyrosine Kinases; D042764:Receptors, TIE