Ethyl(methyl)dioxirane as an efficient reagent for the oxidation of nucleoside phosphites into phosphates under nonbasic anhydrous conditions.
A convenient method for the oxidation of nucleoside phosphites into phosphates under nonbasic and nonaqueous conditions using commercially available ethyl(methyl)dioxirane has been developed. This oxidation is effective with both N-protected and N-unprotected strategies.
Kataoka
M
M
Laboratory of Bioorganic Chemistry, Graduate School of Human Informatics, Nagoya University, Chikusa, Nagoya 464-8601, Japan.
Hattori
A
A
Okino
S
S
Hyodo
M
M
Asano
M
M
Kawai
R
R
Hayakawa
Y
Y
D005027:Ethylene Oxide / Q000031:analogs & derivatives; D007202:Indicators and Reagents; D015394:Molecular Structure; D009705:Nucleosides / Q000737:chemistry*; D009711:Nucleotides / Q000138:chemical synthesis* / Q000737:chemistry*; D010084:Oxidation-Reduction; D017905:Phosphites / Q000737:chemistry*
D007202:Indicators and Reagents; D009705:Nucleosides; D009711:Nucleotides; D017905:Phosphites; C426406:ethyl(methyl)dioxirane; D005027:Ethylene Oxide