Recurrent cleft lip and palate in siblings of a patient with malabsorption syndrome, probably caused by hypovitaminosis a associated with folic acid and vitamin B(2) deficiencies.
We present a woman with metabolic disorders secondary to malabsorption and renal disease who gave birth to a stillborn male fetus with left unilateral cleft lip and palate and a live born infant with left unilateral cleft lip and palate. We discuss potential cofactors that could be implicated in the abnormal embryonic process.
Department of Obstetrics, Centre Hospitalier Universitaire de Québec (CHUQ), Université Laval, Québec, Québec, Canada. gilles.faron@chu-brugman.bc
G
G
Faron
R
R
Drouin
L
L
Pedneault
L D
LD
Poulin
R
R
Laframboise
M
M
Garrido-Russo
W D
WD
Fraser
D000328:Adult; D002971:Cleft Lip / Q000209:etiology*; D002972:Cleft Palate / Q000209:etiology*; D005260:Female; D005494:Folic Acid Deficiency / Q000150:complications*; D006801:Humans; D007223:Infant; D008286:Malabsorption Syndromes / Q000150:complications*; D008297:Male; D012008:Recurrence; D012257:Riboflavin Deficiency / Q000150:complications*; D014802:Vitamin A Deficiency / Q000150:complications*