Blockade of the CD28/B7 and CD40/CD40L costimulatory pathways does not ameliorate chronic rejection in a mouse aortic allograft model of direct antigen presentation.
Section of Cellular Transplantation, Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
J L
JL
Tang
J E
JE
Woodward
V
V
Subbotin
A J
AJ
Logar
H
H
Sun
L A
LA
Valdivia
A T
AT
Schaefer
L B
LB
Zottola
R
R
Peach
J J
JJ
Fung
A S
AS
Rao
D000818:Animals; D017951:Antigen Presentation; D001011:Aorta / Q000473:pathology / Q000637:transplantation*; D018122:B7-1 Antigen / Q000276:immunology; D018106:CD28 Antigens / Q000276:immunology*; D019013:CD40 Antigens / Q000276:immunology*; D023201:CD40 Ligand / Q000276:immunology; D002908:Chronic Disease; D006084:Graft Rejection / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D015398:Signal Transduction; D014184:Transplantation, Homologous; D017539:Tunica Intima / Q000473:pathology
D018122:B7-1 Antigen; D018106:CD28 Antigens; D019013:CD40 Antigens; D023201:CD40 Ligand