Peptide bioregulators inhibit apoptosis.
The effects of peptide bioregulators epithalon and vilon on the dynamics of irradiation-induced apoptotic death of spleen lymphocytes in rats indicate that these agents inhibit physiologically programmed cell death. The antiapoptotic effect of vilon was more pronounced, which corroborates the concept on tissue-specific effect of peptide bioregulators.
Khavinson
V K
VK
Institute of Bioregulation and Gerontology, North-West Division of the Russian Academy of Medical Sciences, St. Petersburg. ibg@medport.ru
Kvetnoii
I M
IM
D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D004151:Dipeptides / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000528:radiation effects
D004151:Dipeptides; D009842:Oligopeptides; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine