Becaplermin and necrobiosis lipoidicum diabeticorum: results of a case control pilot study.
Necrobiosis lipoidica diabeticorum (NLD) is a rare skin condition associated with diabetes, which characteristically occurs in the pretibial region of the lower limbs (Boulton et al., 1988). The lesions generally appear as well-circumscribed reddish plaques, which are most often asymptomatic, resulting primarily in cosmetic disability. Currently, there is no reliable form of treatment for NLD, although many regimens have been tried (Shall et al., 1990)
Department of Veterans Affairs, Medical Center/Portland Division, 3710 S.W. US Veterans Hospital Road, P3-Med, Portland, OR 97207, USA. stephens.elizabeth@portland.va.gov
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Stephens
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Robinson
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Gottlieb
D000287:Administration, Topical; D000077214:Becaplermin; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D006801:Humans; D007866:Leg; D009335:Necrobiosis Lipoidica / Q000188:drug therapy*; D010865:Pilot Projects; D010982:Platelet-Derived Growth Factor / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects
D010982:Platelet-Derived Growth Factor; D020574:Proto-Oncogene Proteins c-sis; D011994:Recombinant Proteins; D000077214:Becaplermin