A histometric study in rats of the effect of the calcium antagonist amlodipine on bone healing after tooth extraction.
The purpose was to investigate whether amlodipine, a second-generation calcium antagonist used for the treatment of hypertension and angina, interferes with healing of rat alveolar bone. A progressive increase in volume density of new bone filling the socket was quantified by a histometric differential point-counting method 7-42 days after tooth extraction. The results showed a 20-30% decrease in bone volume fraction in the alveolus of amlodipine-treated animals from 7 days on, in addition to a higher (7-35%) volume fraction of connective tissue and a tendency toward an increase in the volume fraction of persisting coagulum. If confirmed in humans, the knowledge of a deleterious effect of Ca-channel blockers in hindering alveolar bone healing would be important in planning oral operations involving bone tissue, including those for device implantation.
Teófilo
J M
JM
Department of Morphology, Stomatology and Physiology, Faculdade de Odontologia de Ribeirão Preto-USP, Dental School of Ribeirão Preto, University of São Paulo, Av. do Café s/n, 14040-904 Ribeirão Preto, SP, Brazil.
Brentegani
L G
LG
Carvalho
T L
TL
D017311:Amlodipine / Q000494:pharmacology*; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014081:Tooth Extraction; D020390:Tooth Socket / Q000187:drug effects* / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects
D002121:Calcium Channel Blockers; D017311:Amlodipine