[The changes of plasma endothelin-1 and calcitonin gene-related peptide levels in patients with pregnancy induced hypertension].
OBJECTIVE
To study the changes and clinical significance of plasma endothelin (ET-1) and calcitonin gene-related peptide (CGRP) levels in patients with pregnancy induced hypertension (PIH).


METHODS
Plasma ET-1 and CGRP were studied by immunoradiological method in 60 patients with pregnancy induced hypertension (PIH) and 23 normal pregnant women and 20 normal non-pregnant women.


RESULTS
The levels of plasma ET-1 in patients with PIH were significantly higher than those in healthy pregnancies (P < 0.01). There was a positive correlation between the plasma ET-1 level and degree of PIH; the higher the ET-1 level, the severer the PIH. The levels of plasma CGRP in patients with moderate and severe PIH decreased significantly than those in healthy pregnancy. There was a negative correlation between the plasma CGRP level and ET-1 level.


CONCLUSIONS
The results suggest that plasma ET-1 and CGRP concentration could be used as indicators for the severity of PIH. CGRP may be one of the antagonists of ET-1 in the pathogenesis of PIH.
Second Hospital, Hunan Medical University, Changsha 410011.
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Wang
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Lu
D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000097:blood*; D019332:Endothelin-1 / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood* / Q000209:etiology; D011247:Pregnancy
D019332:Endothelin-1; D015740:Calcitonin Gene-Related Peptide