Midfacial granuloma syndrome or an inflammatory non-specific disease? A case report.
We report a case of idiopathic midline destructive disease in a 57-year-old man. The patient had a non-specific histological pattern in biopsies obtained from the nose and upper lip, characterized by a granulomatous reaction with progressive destruction of the tissues. The patient's general medical history was non-contributory. Clinical and laboratory data did not support any feasible etiology for this destructive process. The patient was treated with prednisone until the discovery of type II diabetes mellitus (never diagnosed before) and was then in turn treated only with oral antidiabetic therapy. Follow-up controls revealed progressive reduction of the symptoms and of the nasal and lip lesions and total remission of symptoms up to 2 years after the onset of the disease. We discuss the diagnostic and subsequent therapeutic problems in the management of the midline necrotizing lesions.
Institute of Ultrastructural Pathology, University of Messina, Italy.
V
V
Torre
S
S
Bucolo
B
B
Galletti
V
V
Cavallari
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D017252:CD3 Complex; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D003937:Diagnosis, Differential; D006103:Granuloma, Lethal Midline / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D013601:T-Lymphocytes / Q000276:immunology
D000893:Anti-Inflammatory Agents; D017252:CD3 Complex; D011241:Prednisone