Interventions for the treatment of twin-twin transfusion syndrome.
BACKGROUND
Twin-twin transfusion syndrome, a condition affecting monochorionic twin pregnancies, is associated with a high risk of perinatal mortality and morbidity. A number of treatments have been introduced to treat the condition but it is unclear which intervention improves maternal and fetal outcome.


OBJECTIVE
The objective of this review was to evaluate the impact of treatment modalities in twin-twin transfusion syndrome.


METHODS
We searched The Cochrane Pregnancy and Childbirth Trials Register and Cochrane Controlled Trials Register. We also searched conference proceedings and made personal contact with experts active in the area of the review. Date of last search: August 2000.


METHODS
Randomised and quasi-randomised studies of amnioreduction versus laser coagulation, septostomy versus laser coagulation or septostomy versus amnioreduction.


METHODS
Eligibility was assessed by one reviewer. Study authors were contacted for additional information.


RESULTS
No studies were included.


CONCLUSIONS
There is no current evidence from randomised trials to influence practice. Three ongoing randomised studies have been identified.
Roberts
D
D
Department of Obstetrics and Gynaecology, Liverpool Women's Hospital NHS Trust, Crown Street, Liverpool, Merseyside, UK, L8 7SS. dkaur@liverpool.ac.uk
Neilson
J P
JP
Weindling
A M
AM
D000649:Amniocentesis / Q000379:methods; D000650:Amnion / Q000601:surgery; D005260:Female; D005330:Fetofetal Transfusion / Q000628:therapy*; D006801:Humans; D017075:Laser Coagulation; D011247:Pregnancy; D018607:Pregnancy Reduction, Multifetal / Q000379:methods; D011677:Punctures; D016032:Randomized Controlled Trials as Topic