X-Ray structure of citrate bound to Src SH2 leads to a high-affinity, bone-targeted Src SH2 inhibitor.
Bohacek
R S
RS
ARIAD Pharmaceuticals, Inc., 26 Landsdowne Street, Cambridge, Massachusetts 02139-4234, USA. regine@ariad.com
Dalgarno
D C
DC
Hatada
M
M
Jacobsen
V A
VA
Lynch
B A
BA
Macek
K J
KJ
Merry
T
T
Metcalf
C A
CA
Narula
S S
SS
Sawyer
T K
TK
Shakespeare
W C
WC
Violette
S M
SM
Weigele
M
M
D000818:Animals; D001549:Benzamides / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001862:Bone Resorption / Q000188:drug therapy; D001842:Bone and Bones / Q000201:enzymology*; D019343:Citric Acid / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003510:Cyclohexanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D017886:Durapatite / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008024:Ligands; D008958:Models, Molecular; D018716:Molecular Mimicry; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D010010:Osteoclasts / Q000473:pathology; D019000:Phosphotyrosine / Q000737:chemistry; D011485:Protein Binding; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000037:antagonists & inhibitors / Q000737:chemistry*; D011817:Rabbits; D018909:src Homology Domains
D001549:Benzamides; D003510:Cyclohexanes; D004791:Enzyme Inhibitors; D008024:Ligands; D009943:Organophosphorus Compounds; D019000:Phosphotyrosine; D019343:Citric Acid; D017886:Durapatite; D016392:Proto-Oncogene Proteins pp60(c-src)