Influence of low-dose oral contraceptives, alcohol, and grapefruit on.
The aminopryine breath test (ABT) measures hepatic reserve in patients with acute and chronic liver disease and gives an assesment of the hepatic function in patients undergoing major liver surgery. Aminopyrine is metabolized by the mixed cytochrome P-450 system, which can be influenced by many foreign compounds and drugs. Whether these foreign compounds and drugs can influence the results of the ABT has seldomly been tested. We studied three groups: Healthy female volunteers, either normally menstruating or taking oral contraceptives, were asked to perform a [13C]ABT during the time of the menses and at midcylce. Healthy volunteers were asked to perform a ABT after consuming 30 g of alcohol. Healthy volunteers were asked to perform a ABT after consuming 250 ml of grapefruit juice. The 13C/12C ratio in expired air was measured by gas isotope ratio mass spectrometry.
Van Vlierberghe
H
H
Department of Gastroenterology, University Hospital, Gent, Belgium.
Van Durme
F
F
Verdievel
H
H
Dhont
M
M
de Vos
M
M
Elewaut
A
A
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000434:Alcoholic Beverages; D000632:Aminopyrine / Q000032:analysis* / Q000378:metabolism; D001628:Beverages; D001944:Breath Tests / Q000379:methods*; D002250:Carbon Radioisotopes; D002908:Chronic Disease; D002957:Citrus; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000175:diagnosis; D008111:Liver Function Tests / Q000379:methods*; D008297:Male; D008598:Menstruation / Q000502:physiology
D002250:Carbon Radioisotopes; D003278:Contraceptives, Oral, Hormonal; D065607:Cytochrome P-450 Enzyme Inhibitors; D000632:Aminopyrine; D004997:Ethinyl Estradiol; D003577:Cytochrome P-450 Enzyme System