Castanospermine, an oligosaccharide processing inhibitor, reduces both lymphocyte-endothelial cell binding and LFA-1alpha membrane expression.
Newcastle Transplant Unit, John Hunter Hospital, Newcastle, Australia.
D A
DA
Clark
A D
AD
Hibberd
P R
PR
Trevillian
W B
WB
Cowden
D002448:Cell Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D007212:Indolizines / Q000494:pharmacology*; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects / Q000378:metabolism; D016169:Lymphocyte Function-Associated Antigen-1 / Q000187:drug effects* / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects* / Q000502:physiology; D054836:Indolizidines
D007166:Immunosuppressive Agents; D007212:Indolizines; D018799:Intercellular Adhesion Molecule-1; D016169:Lymphocyte Function-Associated Antigen-1; C037806:castanospermine; D054836:Indolizidines