Trace level determination of perchlorate in water matrices and human urine using ESI-FAIMS-MS.
High-field asymmetric waveform ion mobility spectrometry (FAIMS) separates perchlorate from interfering isobaric ions of bisulfate and dihydrogenphosphate in the gas-phase. The use of a new FAIMS prototype and waveform generator, along with the use of a mixed carrier gas, in this electrospray ionisation (ESI)-FAIMS-mass spectrometry (MS) study gave a detection limit for perchlorate in a relatively "clean" matrix of tap water of 0.050 ppb. Flow injection analysis (FIA) of dilutions of fortified waste water, a fortified river water certified reference material (CRM; SLRS-4, National Research Council of Canada), and a fortified human urine Standard Reference Material (SRM; 2381, National Institute of Standards and Technology) gave detection limits of 0.37 ppb, 0.50 ppb, and 4.8 ppb, respectively, in the undiluted matrices.
Ells
B
B
Institute for National Measurement Standards, National Research Council of Canada, Ottawa, ON.
Barnett
D A
DA
Purves
R W
RW
Guevremont
R
R
D004784:Environmental Monitoring; D006801:Humans; D010472:Perchlorates / Q000032:analysis / Q000652:urine*; D012680:Sensitivity and Specificity; D017670:Sodium Compounds / Q000032:analysis / Q000652:urine*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000032:analysis*; D014881:Water Supply
D010472:Perchlorates; D017670:Sodium Compounds; D014874:Water Pollutants, Chemical; C031068:sodium perchlorate