Role of thyroid hormones in stress-induced synthesis of heat-shock proteins in the myocardium.
Thyroxine in near-physiological doses increased the content of heat-shock proteins in the myocardium and stimulated their accumulation during immobilization stress. Blockade of thyroid functions with methimazole decreased the content of heat-shock proteins in rat myocardium during stress and heat shock and prevented their accumulation during adaptation to short-term immobilizations.
Laboratory of Molecular Mechanisms of Adaptation, Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
I V
IV
Gorodetskaya
A P
AP
Bozhko
L Y
LY
Bakhtina
I Y
IY
Malyshev
D000222:Adaptation, Physiological; D000818:Animals; D013956:Antithyroid Agents / Q000494:pharmacology; D018840:HSP70 Heat-Shock Proteins / Q000096:biosynthesis; D006360:Heat-Shock Proteins / Q000378:metabolism*; D008297:Male; D008713:Methimazole / Q000494:pharmacology; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism; D013963:Thyroid Hormones / Q000378:metabolism*; D013974:Thyroxine / Q000494:pharmacology
D013956:Antithyroid Agents; D018840:HSP70 Heat-Shock Proteins; D006360:Heat-Shock Proteins; D013963:Thyroid Hormones; D008713:Methimazole; D013974:Thyroxine