[The study on the role of apoptosis suppressive gene bcl-2 in the pathogenesis of hemangioma].
OBJECTIVE
To elucidate the relationship between bcl-2 and hemangioma.


METHODS
We investigated the expression of bcl-2 in 38 samples of hemangioma (19 cases of capillary hemangioma, 10 cases of cavernous hemangioma, 9 cases of racemose hemangioma) and 6 samples of normal skin by immunohistochemical SP method.


RESULTS
The results showed that the expression of bcl-2 was higher in cavernous and racemose hemangioma than in the controls, the expression of bcl-2 was lower in capillary hemangioma than in the controls. The differences were statistically significant.


CONCLUSIONS
It can be deduced from the results that there is an intimate relationship between bcl-2 and the growth of cavernous and racemose hemangioma, and the lower expression of bcl-2 in capillary hemangioma shows that capillary hemangioma may disappear naturally.
Cheng
L
L
Institute of Plastic Surgery, Guangdon Medical College, Guangzhou 524023.
Liang
J
J
Tang
S
S
D000293:Adolescent; D000328:Adult; D017209:Apoptosis / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D016147:Genes, Tumor Suppressor; D019254:Genes, bcl-2; D006391:Hemangioma / Q000209:etiology / Q000235:genetics*; D018324:Hemangioma, Capillary / Q000209:etiology / Q000235:genetics; D006392:Hemangioma, Cavernous / Q000209:etiology / Q000235:genetics; D006801:Humans; D007223:Infant; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis*
D019253:Proto-Oncogene Proteins c-bcl-2