Matrix metalloproteinases of normal human tissues.
This review considers biochemical properties of the family of matrix metalloproteinases (MMPs) of normal human tissues and the involvement of these enzymes in morphogenesis. Four main MMP subfamilies are characterized, and a group of other MMPs is described. Data on mechanisms of activation and inhibition of MMPs in certain tissues during various physiological processes (embryogenesis, angiogenesis, tissue growth and involution) are considered. Information about tissue inhibitors of MMP is presented, and the ability of these inhibitors to regulate the activity of MMPs is analyzed.
Sechenov Moscow Medical Academy, Moscow, 119881, Russia.
P Z
PZ
Khasigov
O V
OV
Podobed
S A
SA
Ktzoeva
T M
TM
Gatagonova
S V
SV
Grachev
S S
SS
Shishkin
T T
TT
Berezov
D006801:Humans; D020782:Matrix Metalloproteinases / Q000145:classification / Q000378:metabolism*; D019714:Tissue Inhibitor of Metalloproteinases / Q000378:metabolism
D019714:Tissue Inhibitor of Metalloproteinases; D020782:Matrix Metalloproteinases