[Genetic abnormality and the mechanism of ingestive disorder in obese animal model].
The objective of this review article is to present the genetic abnormalities in obese animal models up to present times and to suggest the mechanism of ingestive disorder. Leptin is an anorectic ob gene product and activates the anorexigenic POMC and CART neurons in the ARC and suppresses orexigenic NPY and AGRP neurons. TUB gene product also activates the anorexigenic POMC neurons. These anorexigenic neurons project to the second-order hypothalamic neuron, CRH, TRH and so on in the PVN and suppression of orexigenic neurons project to the orexin in the LHA.
First Department of Internal Medicine, Oita Medical University.
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Fukagawa
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Sakata
D000818:Animals; D004195:Disease Models, Animal; D001068:Feeding and Eating Disorders / Q000235:genetics*; D020738:Leptin / Q000235:genetics*; D051379:Mice; D008820:Mice, Obese; D009765:Obesity / Q000235:genetics*; D051381:Rats; D011924:Rats, Zucker
D020738:Leptin