Linear IgA bullous dermatosis induced by atorvastatin.
Linear IgA bullous dermatosis (LABD) is an autoimmune blistering skin disease characterized by circulating IgA antibodies binding the basement membrane zone. In most cases the origin is not clear, but in a minority of cases LABD is drug induced. We describe a patient in whom linear IgA disease developed shortly after beginning therapy with atorvastatin. In Western blotting analysis we detected IgA and IgG class antibodies targeting a 97-kd protein. To our knowledge this is the first reported case of atorvastatin-induced LABD.
Department of Dermatology, University of Cologne, Germany.
C
C
König
A
A
Eickert
K
K
Scharfetter-Kochanek
T
T
Krieg
N
N
Hunzelmann
D000924:Anticholesteremic Agents / Q000009:adverse effects*; D000069059:Atorvastatin; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D006538:Heptanoic Acids / Q000009:adverse effects*; D006801:Humans; D007070:Immunoglobulin A; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000009:adverse effects*; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000276:immunology
D000924:Anticholesteremic Agents; D006538:Heptanoic Acids; D007070:Immunoglobulin A; D011758:Pyrroles; D000069059:Atorvastatin