Long-term developmental outcome of children with complex congenital heart disease.
As the mortality of neonatal and infant surgery for CHD continues to decrease, attention is now focused on long-term sequelae, especially later cognitive and neurologic function, in survivors. Although children with repaired or palliated CHD have an increased risk for neurocognitive deficits, most survivors are performing within the normal range for most standardized measures. Even those children at highest risk, such as patients with HLHS, are comparable with survivors of other congenital lesions, such as diaphragmatic hernia, or low-birth weight children. Continued efforts are underway to reduce cerebral injury before, during, and after congenital heart surgery.
Mahle
W T
WT
Division of Cardiology, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia, USA. mahle@email.chop.edu
Wernovsky
G
G
D002658:Developmental Disabilities / Q000209:etiology*; D005500:Follow-Up Studies; D006330:Heart Defects, Congenital / Q000150:complications* / Q000401:mortality / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D007231:Infant, Newborn; D018743:Perinatal Care; D019990:Perioperative Care; D011379:Prognosis; D012307:Risk Factors; D016019:Survival Analysis; D017741:Survivors; D013997:Time Factors; D016896:Treatment Outcome