Effects of temperature on polyunsaturation in cytostatic lipids of Haslea ostrearia.
Unusual chemicals produced by the-'blue oyster' diatom, Haslea ostrearia, include the water-soluble blue pigment marennine and numerous polyunsaturated sesterterpene oils or haslenes. Aqueous extracts of the alga exhibit in vitro and in vivo activities against human lung cancer cells and anti-HIV effects. Here we report that three haslenes also demonstrate in vitro cytostatic action against a human lung cancer cell line. The most active haslene is the most unsaturated and unsaturation in the haslenes increases with increasing algal growth temperature.
Rowland
S J
SJ
Department of Environmental Sciences, University of Plymouth, UK. s.rowland@plymouth.ac.uk
Belt
S T
ST
Wraige
E J
EJ
Massé
G
G
Roussakis
C
C
Robert
J M
JM
D000475:Alkenes / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D019380:Anti-HIV Agents / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002294:Carcinoma, Squamous Cell; D002470:Cell Survival / Q000187:drug effects; D017377:Diatoms / Q000737:chemistry*; D006678:HIV / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000633:toxicity; D010938:Plant Oils / Q000737:chemistry* / Q000494:pharmacology / Q000633:toxicity; D013729:Terpenes / Q000737:chemistry* / Q000494:pharmacology; D013816:Thermodynamics; D014407:Tumor Cells, Cultured
D000475:Alkenes; D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D010938:Plant Oils; D013729:Terpenes