Cbl: many adaptations to regulate protein tyrosine kinases.
Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?
Department of Pathology, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.
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Thien
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Langdon
D000199:Actins / Q000378:metabolism; D000818:Animals; D029742:Caenorhabditis elegans Proteins; D003599:Cytoskeleton / Q000378:metabolism; D015536:Down-Regulation; D004627:Embryonic Induction; D015801:Helminth Proteins / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008958:Models, Molecular; D050722:Oncogene Protein v-cbl; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D050721:Proto-Oncogene Proteins c-cbl; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D015682:Retroviridae Proteins, Oncogenic / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism
D000199:Actins; D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; C000715470:MAS1 protein, human; D050722:Oncogene Protein v-cbl; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D015682:Retroviridae Proteins, Oncogenic; C095237:Sli-1 protein, C elegans; D014452:Ubiquitins; D050721:Proto-Oncogene Proteins c-cbl; D044767:Ubiquitin-Protein Ligases; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; C067419:CBL protein, human; C493849:Cbl protein, mouse