Sex differences in the acetylcholine receptor kinetics of postnatal and denervated rat muscle.
Single-channel recording from visualised endplates in freshly dissociated muscles from postnatal and denervated rat muscle revealed the presence of a low conductance, fetal type of acetylcholine receptor. Kinetic analysis showed a main component in the burst durations with a mean of 10.8 +/- 2.7 ms (n = 29). Receptors from female rats had an additional 27.3 +/- 5.5 ms (n = 5) kinetic component which was found in one-third of the 15 female endplates. Recordings from male and female denervated muscles gave more homogeneous kinetics with single time constants of 7.2 +/- 1.3 and 7.4 +/- 1.3 ms, respectively. It is concluded that the acetylcholine receptor channels present during early development are different from those of denervated muscle.
Villarroel
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Department of Physiology and Biophysics, Dalhousie University School of Medicine, 3R1 Tupper Medical Building, Halifax, Nova Scotia, Canada B3H 4H7. avillarr@is.dal.ca
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D007700:Kinetics; D008297:Male; D009045:Motor Endplate / Q000502:physiology*; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000294:innervation* / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D011950:Receptors, Cholinergic / Q000502:physiology*; D012727:Sex Characteristics
D011950:Receptors, Cholinergic