[Effect of hypertonic saline/dextran 70 on delayed resuscitation of dogs with burn shock].
OBJECTIVE
To investigate the effect of hypertonic saline/dextran 70 on delayed resuscitation of burn shock.


METHODS
Eighteen mongrel dogs with 35% TBSA, third-degree burn were used in this study. Lactated Ringer's (LR) or 7.5% NaCl+ 6% dextran 70 (HSD) was given for resuscitation 6 h postburn. The volumes and rates of fluid infusion were controlled basically on the urinary output of 1.0 ml.kg-1.h-1 and cardiac output (CO) of 70%-80% of preburn values. The volume load, +dp/dtmax, -dp/dtmax, CI,DO2 and VO2 were obtained to evaluate the effect of HSD resuscitation.


RESULTS
The resuscitated volume of HSD was 30.56% less during first 24 h postburn and 59.50% less at 4 h after resuscitation than LR's. The +dp/dtmax, CI,DO2 and VO2 were increased significantly with HSD infusion at 2 h, 1 h and 0.5 h after resuscitation compared with LR's.


CONCLUSIONS
HSD could expand plasma volume significantly with small quantity. The cardiac contractility was enhanced and the oxygen delivery, oxygen consumption were increased in delayed resuscitation of burn shock.
Burn Centre of 97th Hospital, People's Liberation Army, Xuzhou 221004.
D
D
Wang
S
S
Sun
Z
Z
Mao
D000818:Animals; D002056:Burns / Q000150:complications / Q000188:drug therapy*; D003911:Dextrans / Q000627:therapeutic use*; D004285:Dogs; D011897:Random Allocation; D012151:Resuscitation; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D012774:Shock, Traumatic / Q000188:drug therapy* / Q000209:etiology
D003911:Dextrans; D012462:Saline Solution, Hypertonic