Effects of scopolamine on working memory in rats in a delayed matching-to-position task, employing a subject-centered procedure.
The effect of scopolamine hydrobromide on a delayed matching-to-position task was examined while controlling for two confounding factors, i.e., mediating behavior and slow performance on a task. The task was given on the basis of a subject-centered method in which delay intervals are dependent on subjects' performance. The performance of individual subjects, rather than averaged group performance, was taken as the focus of the analysis. The results indicated that scopolamine had an effect not only on speed of performing the task but also on the length of the retention interval. The effects differed considerably among individuals: the effects on both the length of the retention interval and the speed of performance were found for two of the five subjects. An effect on speed of performance alone was found for one subject. No effects on either measure were found in a further two subjects.
Institute for Developmental Research, Aichi Prefectural Colony, Kasugai, Aichi 480-03, Japan.
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Oka
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Tachibana
D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D011939:Mental Recall / Q000187:drug effects*; D009949:Orientation / Q000187:drug effects*; D010364:Pattern Recognition, Visual / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012153:Retention, Psychology / Q000187:drug effects*; D012601:Scopolamine / Q000494:pharmacology*
D012601:Scopolamine