The inhibition of the transplacental blastomogenic effect of nitrosomethylurea by postnatal administration of buformin to rats.
N-Nitrosomethylurea (NMU) (20 mg/kg) was i.p. administered to rats on the 21st day of pregnancy. A decrease of glucose utilisation in the oral glucose tolerance test was found in 3 month old female progeny of NMU-treated rats. The serum insulin level did not differ from control, but serum cholesterol level was higher in offspring of NMU-treated rats. The ability of diethylstilboestrol to inhibit compensatory ovarian hypertrophy was decreased in female hemicastrated 3 month old rats whose mothers were treated with NMU. Postnatal administration of the antidiabetic drug buformin decreased the malignant neurogenic tumor incidence 3.5 times (to rats transplacentally treated with NMU).
Laboratory of Experimental Tumours, N. N. Petrov Research Institute of Oncology, Leningrad, USSR.
V A
VA
Alexandrov
V N
VN
Anisimov
N M
NM
Belous
I A
IA
Vasilyeva
V B
VB
Mazon
D000818:Animals; D002026:Buformin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D004040:Dietary Carbohydrates / Q000493:pharmacokinetics; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005951:Glucose Tolerance Test; D006984:Hypertrophy; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000196:embryology / Q000517:prevention & control; D008297:Male; D008431:Maternal-Fetal Exchange; D008770:Methylnitrosourea / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000196:embryology / Q000517:prevention & control*; D009380:Neoplasms, Nerve Tissue / Q000139:chemically induced / Q000196:embryology / Q000517:prevention & control; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000196:embryology / Q000517:prevention & control; D010052:Ovariectomy; D010053:Ovary / Q000187:drug effects / Q000473:pathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013002:Somatomedins / Q000172:deficiency
D004040:Dietary Carbohydrates; D007004:Hypoglycemic Agents; D007328:Insulin; D013002:Somatomedins; D008770:Methylnitrosourea; D004054:Diethylstilbestrol; D002784:Cholesterol; D002026:Buformin; C000937:diethylstilbestrol dipropionate