Nineteen documented cases of Loxosceles reclusa envenomation.
OBJECTIVE
Our purpose was to review documented Loxosceles reclusa (brown recluse spider) envenomations and to describe the natural history.


METHODS
This article is a retrospective review of 19 documented cases seen in a university dermatology clinic. The study included the cases of 11 female and 8 male patients between the ages of 15 and 54 years with documented cases of brown recluse spider bite between 1987 and 1993. Rest, ice compresses, elevation, and prophylactic antibiotics were used in all cases. Fourteen patients received dapsone and 11 received nonsteroidal anti-inflammatory drugs. Two patients were hospitalized. A 3-point scale of cutaneous lesion severity was developed. Analysis of the association between maximum lesion severity (mild, moderate, severe) and time to complete healing or final evaluation was statistically significant (P < .001).


RESULTS
All patients presented with localized erythema. Most bites were on the extremities (18/19; 95%). The most common presenting symptom was pain at the bite site (10/19; 53%). Eleven patients (58%) had skin necrosis; 32% of them had areas of necrosis larger than 1 cm(2). Time to healing ranged from 5 days to more than 17 weeks (mean, 5.6 weeks). Average time to healing for grade 3 (severe) lesions was 74 days, for grade 2 (moderate) lesions 22 days, and for grade 1 (mild) lesions 8 days (in patients seen more than once).


CONCLUSIONS
Brown recluse spider bites frequently induce necrotic, slowly healing lesions. Maximum lesion severity is a predictor of time to complete healing.
Department of Medicine, Division of Dermatology, Vanderbilt University, Nashville, TN 37232-5227, USA.
H H
HH
Sams
S B
SB
Hearth
L L
LL
Long
D C
DC
Wilson
D H
DH
Sanders
L E
LE
King
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D001098:Spider Bites / Q000150:complications / Q000175:diagnosis / Q000628:therapy