Heterogeneity of the ribosome-inactivating protein trichosanthin in Trichosanthes kirilowii tubers.
The ribosome-inactivating protein trichosanthin isolated from the tubers of Trichosanthes kirilowii, the Chinese drug Tianhuafen, has a molecular mass of approximately 26 kDa. We show here that T. kirilowii tubers also contain ribosome-inactivating proteins with a small extent of structural variation from and a larger molecular mass than trichosanthin.
Department of Microbiology, China Agricultural University, Beijing, PR China.
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D000595:Amino Acid Sequence; D015153:Blotting, Western; D002850:Chromatography, Gel / Q000379:methods; D004365:Drugs, Chinese Herbal / Q000032:analysis* / Q000302:isolation & purification; D004591:Electrophoresis, Polyacrylamide Gel; D037102:Lectins / Q000378:metabolism; D008969:Molecular Sequence Data; D037121:Plant Lectins; D010940:Plant Proteins / Q000032:analysis* / Q000302:isolation & purification; D010946:Plants, Medicinal / Q000737:chemistry*; D011500:Protein Synthesis Inhibitors / Q000032:analysis* / Q000302:isolation & purification; D012270:Ribosomes / Q000187:drug effects*; D015978:Trichosanthin / Q000032:analysis* / Q000302:isolation & purification
D004365:Drugs, Chinese Herbal; D037102:Lectins; D037121:Plant Lectins; D010940:Plant Proteins; D011500:Protein Synthesis Inhibitors; D015978:Trichosanthin