[Epileptogenic drugs in anesthesia].
Most anaesthetics and analgesics have both pro- and anticonvulsant activity. The data in the literature should be analysed with respect to the patient population, the recording of epileptic activity and the method of EEG analysis. Among inhaled anaesthetics, isoflurane has strong anticonvulsant properties. In some circumstances, sevoflurane may induce an epileptic activity. With the exception of ketamine and etomidate, all intravenous hypnotics may be used for anesthesia of the epileptic patient. Midazolam is a potent anticonvulsant. Among narcotics, fentanyl and alfentanil may induce clinical or electroencephalographic seizures. Considering the large number of patients treated with these agents without any neurological adverse effect, the clinical relevance of these data is unclear. Neuromuscular blocking agents do not possess pro- or anticonvulsant properties.
Département d'anesthésie-réanimation, CHU Timone, 13385 Marseille, France. nbruder@ap-hm.fr
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Bonnet
D000777:Anesthetics / Q000009:adverse effects*; D000818:Animals; D004569:Electroencephalography / Q000187:drug effects; D004827:Epilepsy / Q000139:chemically induced*; D006801:Humans
D000777:Anesthetics