Optimizing the use of beta-blockers in the effective treatment and management of heart failure: a case study approach.
Today, heart failure is an increasing concern in the United States. Its prognoses are poor and its treatment is a complicated endeavor, because heart failure is not a single disease state. Rather, it is a syndrome with a cyclic pathophysiology composed of multiple mechanisms. Effective case management of heart failure must address each of the many changes involved in this syndrome, and therapy must be individualized, especially because patients with heart failure often require regimens of five or more drugs. In special populations, such as the elderly and/or patients with concomitant diseases requiring added medication, polypharmacy becomes an important issue. Maintaining consistent compliance with the treatment regimen and patient education regarding symptoms of fluid retention can be critical. Currently, beta-blockers, in addition to standard therapy, are recommended as first-line treatment in mild-to-moderate heart failure. The three cases presented in this article illustrate some common scenarios encountered and clinical decisions made when beta-blockers are used in the management of heart failure.
Eichhorn
E J
EJ
Department of Internal Medicine, Division of Cardiology, The University of Texas, Southwestern Medical Center, the Cardiac Catheterization Laboratory, Dallas Veterans Administration Medical Center, (EJE), Dallas, Texas, USA.
Young
J B
JB
D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D003327:Coronary Disease / Q000150:complications; D006333:Heart Failure / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications; D009203:Myocardial Infarction / Q000150:complications; D019338:Polypharmacy; D013318:Stroke Volume; D017180:Tachycardia, Ventricular / Q000150:complications
D000319:Adrenergic beta-Antagonists