[The clinical significance of biological characters on non-small cell lung cancer].
OBJECTIVE
To study the biological characters of 137 cases of surgically treated NSCLC and their correlation with stages, types and survival rates.


METHODS
Electronmicroscopy, immunohistochemistry and FCM were employed in this prospective, randomized study. K-P curve, COX univariance and multivariance were used for statistic analysis.


RESULTS
(1) Electronmicroscopy showed that 40% of squamous cancer and 40% of adenocarcinoma diagnosed microscopically were mixed type. (2) The positive rate of p53 expression increased in advanced stage of NSCLC, and the survival rate was lower in cases with positive p53 expression. (3) A higher survival rate was seen in cases with positive Hras expression. (4) Lower survival rates were seen in cases with abnormal DI and PI. (5) Miscellaneous: expression rates of c-erbB2 and PCNA were related to adenocarcinoma and mixed type electronmicroscopically confirmed respectively.


CONCLUSIONS
From this study p53, Hras, DI, PI, c-erbB2 and PCNA were found related to stages, types and survival rates, respectively.
Shanghai Chest Hospital, Shanghai 200030.
M
M
Liao
Z
Z
Lin
Y
Y
Zhou
D000230:Adenocarcinoma / Q000235:genetics / Q000473:pathology / Q000628:therapy; D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics / Q000473:pathology / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000473:pathology / Q000628:therapy; D018734:Genes, erbB-2; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology / Q000628:therapy; D009367:Neoplasm Staging; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D011446:Prospective Studies; D015996:Survival Rate
D018809:Proliferating Cell Nuclear Antigen