Combined liver and pancreatic islets transplantation in man using cyclosporin immunosuppression.
We report a 1-year patient and graft survival after combined liver-pancreatic islet transplantation. The patient was affected by a pancreatic neuroendocrine carcinoma with extensive liver metastasis. Native pancreas and total liver removal was undertaken after a good response to chemotherapy, and the patient was still cancer-free 1 year later. Normal liver function and insulin independence was achieved, although islet response to glucose challenge remained delayed. Immunosuppression was maintained with cyclosporin monotherapy.
Department of Surgery, Istituto Nazionale Tumori, Milan, Italy.
V
V
Mazzaferro
C
C
Socci
E
E
Regalia
S
S
Andreola
M
M
Di Bartolomeo
F
F
Bertuzzi
V
V
Di Carlo
G
G
Pozza
R
R
Doci
F
F
Bozzetti
L
L
Gennari
D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D016381:Islets of Langerhans Transplantation / Q000379:methods / Q000502:physiology*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D007328:Insulin; D016572:Cyclosporine