Factors related to sexual function in postmenopausal women with a history of breast cancer.
BACKGROUND
The normal life expectancy of survivors of early-stage breast cancer (BCS) underscores the need to address long-term quality of life issues in these women. Sexual dysfunction persists after breast cancer treatment, despite recovery in other domains.


OBJECTIVE
To examine associations between a broad array of characteristics and sexuality in BCS.


METHODS
Sixty-one postmenopausal BCS who were participants in a randomized, controlled trial of nonhormonal interventions for menopause symptoms and who had a partnered, intimate relationship.


METHODS
Cross-sectional analysis of baseline trial data. Outcomes were standardized scales of sexual interest, dysfunction, and satisfaction. Candidate predictors included demographic, anatomical, medical, psychological, sociocultural, and hormonal characteristics. Forward, stepwise regression was used.


RESULTS
Relationship quality, vaginal discomfort, education, and hot flashes were each associated with two of the three domains of sexuality assessed. Ten other factors entered predictive models: age, time since diagnosis, breast conservation, comorbidity, urinary incontinence, perceived health, body image, bioavailable testosterone, luteinizing hormone, and sex hormone binding globulin. Each of these 10 factors was associated with only one sexuality domain.


CONCLUSIONS
In this small sample of BCS, we found multiple correlates of sexuality. Most seem to impact uniquely on individual domains of sexual function. Several characteristics are modifiable and could be targets for intervention.
Division of Geriatrics, UCLA School of Medicine, Los Angeles, CA 90095-1687, USA.
G A
GA
Greendale
L
L
Petersen
L
L
Zibecchi
P A
PA
Ganz
D000328:Adult; D000367:Age Factors; D000368:Aged; D001828:Body Image; D001943:Breast Neoplasms / Q000150:complications / Q000628:therapy; D003430:Cross-Sectional Studies; D004522:Educational Status; D005260:Female; D006304:Health Status; D019584:Hot Flashes; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D017698:Postmenopause; D012044:Regression Analysis; D012738:Sex Hormone-Binding Globulin / Q000032:analysis; D012735:Sexual Dysfunction, Physiological / Q000453:epidemiology / Q000209:etiology*; D017741:Survivors; D013739:Testosterone / Q000097:blood; D014549:Urinary Incontinence; D014623:Vaginal Diseases
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D007986:Luteinizing Hormone