Conformational properties of serine proteinase inhibitors (serpins) confer multiple pathophysiological roles.
Serine proteinase inhibitors (Serpins) are irreversible suicide inhibitors of proteases that regulate diverse physiological processes such as coagulation, fibrinolysis, complement activation, angiogenesis, apoptosis, inflammation, neoplasia and viral pathogenesis. The molecular structure and physical properties of serpins permit these proteins to adopt a number of variant conformations under physiological conditions including the native inhibitory form and several inactive, non-inhibitory forms, such as complexes with protease or other ligands, cleaved, polymerised and oxidised. Alterations of a serpin which affect its structure and/or secretion and thus reduce its functional levels may result in pathology. Serpin dysfunction has been implicated in thrombosis, emphysema, liver cirrhosis, immune hypersensitivity and mental disorders. The loss of inhibitory activity of serpins necessarily results in an imbalance between proteases and their inhibitors, but it may also have other physiological effects through the generation of abnormal concentrations of modified, non-inhibitory forms of serpins. Although these forms of inhibitory serpins are detected in tissues and fluids recovered from inflammatory sites, the important questions of which conditions result in generation of different molecular forms of serpins, what biological function these forms have, and which of them are directly linked to pathologies and/or may be useful markers for characterisation of disease states, remain to be answered. Elucidation of the biological activities of non-inhibitory forms of serpins may provide useful insights into the pathogenesis of diseases and suggest new therapeutic strategies.
Department of Medicine, Wallenberg Laboratory, Ing. 46, Malmö University Hospital, S-20502, Malmö, Sweden. sabina.janciauskiene@medforsk.mas.lu.se
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Janciauskiene
D000544:Alzheimer Disease / Q000503:physiopathology; D000818:Animals; D006801:Humans; D008958:Models, Molecular; D019636:Neurodegenerative Diseases / Q000503:physiopathology*; D010084:Oxidation-Reduction; D011487:Protein Conformation; D020033:Protein Isoforms / Q000737:chemistry / Q000502:physiology; D015842:Serine Proteinase Inhibitors / Q000737:chemistry* / Q000502:physiology*; D015843:Serpins / Q000737:chemistry* / Q000502:physiology*; D013329:Structure-Activity Relationship; D000514:alpha 1-Antichymotrypsin / Q000737:chemistry / Q000502:physiology; D000515:alpha 1-Antitrypsin / Q000737:chemistry / Q000502:physiology
D020033:Protein Isoforms; D015842:Serine Proteinase Inhibitors; D015843:Serpins; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin