Ligand-gated purinergic receptors are differentially expressed in the adult rat vestibular periphery.
To further characterize the pattern of expression of the ligand-gated purinergic P2X receptors in the peripheral vestibular system, we conducted reverse transcription-polymerase chain reaction amplification of P2X1 and P2X2 messenger RNA extracted from adult rat vestibular ganglia (Scarpa's ganglia) and vestibular end organs. Transcripts encoding P2X1 were found in both Scarpa's ganglia and the end organs, but transcripts encoding P2X2 were found only in the vestibular end organs. These results support previous electrophysiological data, and they provide a more complete understanding of the specific role of purinergic (adenosine-5'-triphosphate) transmission in the vestibular periphery.
Department of Pediatrics, College of Physicians and Surgeons, Columbia University, New York, New York, USA.
J L
JL
Kreindler
M
M
Troyanovskaya
P A
PA
Wackym
D000818:Animals; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D011983:Receptors, Purinergic / Q000096:biosynthesis* / Q000235:genetics; D014722:Vestibule, Labyrinth
D012333:RNA, Messenger; D011983:Receptors, Purinergic