Modifying the temporal profile of the high-potency sweetener neotame.
It is possible, using hydrophobic organic acids (such as cinnamate) or hydroxyamino acids (such as serine and tyrosine), to modify the temporal profile of the high-potency sweetener neotame. On the basis of Monte Carlo simulations, it was concluded that it is unlikely that this effect is due to direct interaction between the neotame molecule and the taste modifier. It is shown, using conformational analysis and molecular modeling, that the taste modifiers can adopt low-energy conformers which mimic the proposed active conformation of neotame, which suggests that the modifiers may compete for binding at the receptor site.
Prakash
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I
The NutraSweet Company, 699 Wheeling Road, Mount Prospect, Illinois 60056, USA.
Bishay
I E
IE
Desai
N
N
Walters
D E
DE
D002934:Cinnamates; D004151:Dipeptides / Q000737:chemistry*; D004355:Drug Stability; D008958:Models, Molecular; D008968:Molecular Conformation; D009010:Monte Carlo Method; D012694:Serine; D013549:Sweetening Agents / Q000737:chemistry*; D013649:Taste; D014443:Tyrosine
D002934:Cinnamates; D004151:Dipeptides; D013549:Sweetening Agents; D014443:Tyrosine; D012694:Serine; C404525:neotame