[Effect of furosemide on the carbonic anhydrase activity in vestibule].
In order to explore the mechanism that the furosemide dehydrates and improves the vestibular function in the endolymphatic hydrops. The effects of furosemide on the carbonic anhydrase activity in vestibule were studied by using histocytochemistry and image analysis. The results demonstrated that the furosemide can obviously inhibit the carbonic anhydrase activity. There was no significant difference between the normal ear and the ear with endolymphatic hydrops in the location of the carbonic anhydrase in the vestibule. It suggested that one of the dehydrant mechanisms is inhibition of carbonic anhydrase activity.
Department of Otolaryngology, 254 Hospital, Tianjin 300142.
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D000818:Animals; D002256:Carbonic Anhydrases / Q000378:metabolism*; D004232:Diuretics / Q000494:pharmacology; D018159:Endolymphatic Hydrops / Q000201:enzymology*; D005665:Furosemide / Q000494:pharmacology*; D006168:Guinea Pigs; D011897:Random Allocation; D014722:Vestibule, Labyrinth / Q000201:enzymology*
D004232:Diuretics; D005665:Furosemide; D002256:Carbonic Anhydrases