Studies on aging piroxicam-polyvinylpyrrolidone solid dispersions.
The stabilities of X-ray amorphous solid dispersions of piroxicam and polyvinylpyrrolidone (PVP) K-17 and PVP K-30 (1:5 and 1:4), respectively, were investigated after storage for 12 months. X-ray diffraction showed that in the aged solid dispersions piroxicam remained in the amorphous state. Fourier transform infrared (FTIR) spectroscopy indicated that the interactions between drug and PVP in aged solid dispersions are similar to those in freshly prepared samples. The dissolution rates of the X-ray amorphous solid dispersions during storage for 12 months at 45 degrees C and ambient temperature were examined. Very minor decreases in dissolution rates of aged solid dispersions were found which might be due to the coarsening of the particles. Dissolutions of these amorphous solid dispersions after aging for 12 months still showed an about 40-fold increase in dissolution in 5 min compared to pure drug.
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkla University, Songkhla, Thailand. isuthima@ratree.psu.ac.th
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Ingkatawornwong
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Kaewnopparat
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Tantishaiyakul
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D004355:Drug Stability; D010592:Pharmaceutic Aids; D010894:Piroxicam / Q000737:chemistry*; D011205:Povidone; D012995:Solubility; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010592:Pharmaceutic Aids; D010894:Piroxicam; D011205:Povidone