Itraconazole-enhanced vincristine neurotoxicity in a child with acute lymphoblastic leukemia.
A boy with acute lymphoblastic leukemia (ALL) experienced life-threatening vincristine neurotoxicity while simultaneously exposed to itraconazole. Five pediatric and six adult cases of itraconazole-enhanced vincristine toxicity have been reported, all with ALL. Upon cessation of the itraconazole, the patient's symptoms resolved, which is similar to the outcome of the previously reported cases: 10 of 11 patients had complete resolution of symptoms.
Department of Pediatric Hematology/Oncology, Children's Hospital Oakland, Oakland, California, USA.
M R
MR
Jeng
J
J
Feusner
D000935:Antifungal Agents / Q000008:administration & dosage / Q000633:toxicity; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000633:toxicity; D001393:Azoles / Q000008:administration & dosage / Q000633:toxicity; D002675:Child, Preschool; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000150:complications; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage / Q000633:toxicity*
D000935:Antifungal Agents; D000972:Antineoplastic Agents, Phytogenic; D001393:Azoles; D017964:Itraconazole; D014750:Vincristine