D-TRP-6-LHRH (Triptorelin) is not effective in ovarian carcinoma: an EORTC Gynaecological Cancer Co-operative Group Study.
Between March and September 1988, 74 patients with progressive ovarian cancer after prior platinum-based therapy were treated with the luteinizing hormone-releasing hormone (LHRH) agonist Triptorelin (Decapeptyl degrees). Treatment consisted of i.m. injection of 3.75 mg of microencapsulated Triptorelin on days 1, 8 and 28 followed by 4-weekly injections until tumor progression. No objective responses were observed. Eleven out of 68 evaluable patients (16%) had stable disease. The median progression-free survival was 5 months in patients with disease stabilization and 2 months for all evaluable patients. The median survival for patients with disease stabilization was 17 months, whereas for all patients it was 4 months. The treatment was well tolerated; the only reported adverse events were incidental hot flushes. This study showed that the LHRH agonist Triptorelin has only modest efficacy in patients pretreated with platinum-containing chemotherapy.
EORTC Data Centre, Brussels, Belgium. fdu@eortc.be
F
F
Duffaud
M E
ME
van der Burg
M
M
Namer
I
I
Vergote
Willemse PHB
W
W
ten Bokkel Huinink
J P
JP
Guastalla
Nooij
P
P
Kerbrat
M
M
Piccart
S
S
Tumolo
G
G
Favalli
N
N
van der Vange
A J
AJ
Lacave
J
J
Wils
T A
TA
Splinter
N
N
Einhorn
K J
KJ
Roozendaal
R
R
Rosso
J B
JB
Vermorken
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy* / Q000401:mortality; D004341:Drug Evaluation; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality; D017671:Platinum Compounds / Q000627:therapeutic use; D016879:Salvage Therapy; D015996:Survival Rate; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D018931:Antineoplastic Agents, Hormonal; D017671:Platinum Compounds; D017329:Triptorelin Pamoate