Comparison of plasma-sprayed hydroxyapatite coatings and hydroxyapatite/tricalcium phosphate composite coatings: in vivo study.
This study aimed to compare biological properties, including osteoconduction, osseointegration, and shear strength, between plasma-sprayed hydroxyapatite (HA) and HA/tricalcium phosphate (TCP) coatings, using a transcortical implant model in the femora of canines. After 3 and 12 weeks of implantation, the implants with surrounding bone were assessed histologically in undecalcified sections in backscattered electron images (BEIs) under a scanning electron microscope (SEM). After short-term (3 week) follow-up, both coatings conducted new bone formation and revealed direct bone-to-coating contact. The HA/TCP coating could not enhance early host-to-coating responses. At 12 weeks, serious dissolution of the HA/TCP coatings evidently occurred. By the new bone healing index (NBHI) and apposition index (AI), we found no significant difference between HA/TCP-coated implants and HA-coated implants throughout all implant periods. At 12 weeks of implantation, some particles dissociated from the HA/TCP coating were found within the remodeling canal. After push-out measurements, the shear strength and failure mode of HA/TCP-coated implants were similar to those of HA-coated implants, and no statistical differences were found between either coating. Consequently, this study indicates that HA/TCP coatings have excellent biological response and may be considered suitable bioactive ceramic coatings for short-term clinical use.
Department of Materials Science and Engineering, National Cheng Kung University, Tainan, Taiwan, ROC. tmlee@cubic.mat.ncku.edu.tw
T M
TM
Lee
B C
BC
Wang
Y C
YC
Yang
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E
Chang
C Y
CY
Yang
D000818:Animals; D001696:Biomechanical Phenomena; D018786:Bone Substitutes; D001842:Bone and Bones / Q000502:physiology / Q000601:surgery; D002130:Calcium Phosphates; D002516:Ceramics; D004285:Dogs; D017886:Durapatite; D006801:Humans; D008422:Materials Testing; D008855:Microscopy, Electron, Scanning; D016348:Osseointegration; D013499:Surface Properties; D014945:Wound Healing
D018786:Bone Substitutes; D002130:Calcium Phosphates; C485817:beta-tricalcium phosphate; D017886:Durapatite; C018392:tricalcium phosphate