Synthesis and study of some 4-aza and 17a-azasteroidal isoxazoles.
4-Aza-5 alpha-androstano[2,3-d]isoxazole 4 and 17a-aza-D-homo-5-androsteno[17,16-c]isoxazole 7 have been prepared by treating alpha,beta-unsaturated-beta-chloroaldehydes 3 and 6 [1, 2] with hydroxylamine hydrochloride in pyridine. [16,17-d]Isoxazole derivatives 4 and 8 were found to be unstable in most of the organic solvents. beta-Cyanolactam derivatives 5 and 9 have also been prepared in both the series.
University Institute of Pharmaceutical Sciences, Panjab University, 160014, Chandigarh, India.
R
R
Gupta
D
D
Pathak
D P
DP
Jindal
D000736:Androstenes / Q000138:chemical synthesis* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D047072:Aromatase Inhibitors; D001378:Azasteroids / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007202:Indicators and Reagents; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D010920:Placenta / Q000187:drug effects / Q000201:enzymology; D012997:Solvents; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
C436720:17-aza-D-homo-5-androsteno(17,16-c)isoxazole; C436719:4-Aza-5-androstano(2,3-d)isoxazole; D000736:Androstenes; D000970:Antineoplastic Agents; D047072:Aromatase Inhibitors; D001378:Azasteroids; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D007555:Isoxazoles; D012997:Solvents