[Effect of mouth wash on the removing fluticasone propionate delivered by dry powder inhaler in mouth].
The effect of mouth wash on the removal of drug residues in both mouth and pharynx after the use of fluticasone propionate dry powder inhaler (FP-DPI) was studied. The concentration of FP in mouth wash after sprinkle and inhalation of Flutide 50, 100, 200 Rotadisk was determined by HPLC-UV. The total amount of the removed FP was measured by the sum of the concentration of FP in 5 times of mouth washes. The mouth wash procedures removed totally 79.3 +/- 4.4% (50 micrograms), 68.5 +/- 3.6% (100 micrograms), 69.3 +/- 3.4% (200 micrograms) of sprinkled amount of FP and 29.5 +/- 11.1% (50 micrograms), 35.6 +/- 6.6% (100 micrograms), 31.6 +/- 8.3% (200 micrograms) of inhaled, respectively. It was required for the removal of 90% of the totally recovered FP to do two times of mouth washes in each case. These data suggest that the mouth wash is an effective precaution for candidiasis induced by FP delivered by DPI.
Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan.
H
H
Yokoyama
Y
Y
Yamada
Y
Y
Yamamura
H
H
Nakamura
T
T
Iga
D000280:Administration, Inhalation; D000327:Adsorption; D000328:Adult; D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D002180:Candidiasis, Oral / Q000209:etiology / Q000517:prevention & control; D004350:Drug Residues; D000068298:Fluticasone; D006801:Humans; D009055:Mouth / Q000378:metabolism*; D009067:Mouthwashes; D011208:Powders
D000730:Androstadienes; D009067:Mouthwashes; D011208:Powders; D000068298:Fluticasone