The measurement of thermal neutron flux depression for determining the concentration of boron in blood.
Boron neutron capture therapy (BNCT) is a form of targeted radiotherapy that relies on the uptake of the capture element boron by the volume to be treated. The treatment procedure requires the measurement of boron in the patient's blood. The investigation of a simple and inexpensive method for determining the concentration of the capture element 10B in blood is described here. This method, neutron flux depression measurement, involves the determination of the flux depression of thermal neutrons as they pass through a boron-containing sample. It is shown via Monte Carlo calculations and experimental verification that, for a maximum count rate of 1 x 10(4) counts/s measured by the detector, a 10 ppm 10B sample of volume 20 ml can be measured with a statistical precision of 10% in 32 +/- 2 min. For a source activity of less than 1.11 x 10(11) Bq and a maximum count rate of less than 1 x 10(4) counts/s, a 10 ppm 10B sample of volume 20 ml can be measured with a statistical precision of 10% in 58 +/- 3 min. It has also been shown that this technique can be applied to the measurement of the concentration of any element with a high thermal neutron cross section such as 157Gd.
Brooke
S L
SL
Medical Physics Department, Queen Elizabeth Hospital, Edgbaston, Birmingham, UK. sarah.brooke@msexc.addenbrookes.anglox.nhs.uk
Green
S
S
Charles
M W
MW
Beddoe
A H
AH
D001895:Boron / Q000097:blood*; D016754:Boron Neutron Capture Therapy; D004867:Equipment Design; D005682:Gadolinium / Q000097:blood; D005720:Gamma Rays; D006801:Humans; D007554:Isotopes; D009010:Monte Carlo Method; D009502:Neutrons; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
D007554:Isotopes; D005682:Gadolinium; D001895:Boron