In vitro activities of linezolid against multiple Nocardia species.
Linezolid was tested by broth microdilution against 140 clinical Nocardia isolates belonging to seven species. The MIC at which 50% of the strains are inhibited (MIC50) and MIC90 for all species other than Nocardia farcinica were 2 and 4 microg/ml. Linezolid is the first antimicrobial agent demonstrated to be active against all Nocardia species.
Brown-Elliott
B A
BA
Department of Microbiology, University of Texas Health Center, Tyler, Texas 75708, USA. barbara.elliot@uthct.edu
Ward
S C
SC
Crist
C J
CJ
Mann
L B
LB
Wilson
R W
RW
Wallace
R J
RJ
D000081:Acetamides / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000069349:Linezolid; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000187:drug effects*; D023303:Oxazolidinones / Q000494:pharmacology*; D013045:Species Specificity
D000081:Acetamides; D000900:Anti-Bacterial Agents; D023303:Oxazolidinones; D000069349:Linezolid