Molecular motors involved in T cell receptor clusterings.
Engagement of antigen receptors on T and B cells triggers reorganization of the cytoskeleton and ordered clustering of cell surface receptors. These receptor clusters constitute spatially organized signaling machines and form the immune synapse with antigen-presenting cells. Formation of supramolecular activation clusters appear to be essential to induce functional lymphocyte responses and have been implicated as molecular mechanisms of costimulation. The Vav1-Rho-GTPase-WASP pathway constitutes a molecular motor that relays antigen receptor stimulation to changes in the cytoskeleton and receptor clustering.
Amgen Institute/Ontario Cancer Institute, Department of Medical Biophysics, University of Toronto, Canada.
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Krawczyk
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JM
Penninger
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D001402:B-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology / Q000502:physiology; D020409:Molecular Motor Proteins / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology
D020409:Molecular Motor Proteins; D011948:Receptors, Antigen, T-Cell