Tumors in long-term rat studies associated with microchip animal identification devices.
Tumors surrounding implanted microchip animal identification devices were noted in two separate chronic toxicity/oncogenicity studies using F344 rats. The tumors occurred at a low incidence rate (approximately 1 percent), but did result in the early sacrifice of most affected animals, due to tumor size and occasional metastases. No sex-related trends were noted. All tumors occurred during the second year of the studies, were located in the subcutaneous dorsal thoracic area (the site of microchip implantation) and contained embedded microchip devices. All were mesenchymal in origin and consisted of the following types, listed in order of frequency: malignant schwannoma, fibrosarcoma, anaplastic sarcoma, and histiocytic sarcoma. The following diagnostic techniques were employed: light microscopy, scanning electron microscopy, and immunohistochemistry. The mechanism of carcinogenicity appeared to be that of foreign-body induced tumorigenesis.
Elcock
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LE
Bayer Corporation, Toxicology Department, Stilwell, Kansas 66085, USA. laura.elcock.b@bayer.com
Stuart
B P
BP
Wahle
B S
BS
Hoss
H E
HE
Crabb
K
K
Millard
D M
DM
Mueller
R E
RE
Hastings
T F
TF
Lake
S G
SG
D000823:Animal Identification Systems; D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000648:ultrastructure; D005549:Foreign-Body Reaction / Q000209:etiology* / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D008904:Miniaturization / Q000295:instrumentation; D009442:Neurilemmoma / Q000209:etiology* / Q000556:secondary; D019736:Prostheses and Implants; D051381:Rats; D011916:Rats, Inbred F344; D012509:Sarcoma / Q000209:etiology* / Q000556:secondary; D012983:Soft Tissue Neoplasms / Q000209:etiology* / Q000473:pathology