[Detection tonsillar pathology by superoxide dismutase levels. Comparative study of surgical indications for tonsillectomy].
If oxygen-derived free radicals are considered the definitive cause of tonsillar damage after infection, it seems reasonable that scavenger antioxidants levels could be used as a detector of tissue impairment. So, superoxide dismutase (SOD) amounts were measured in palatine tonsils and peripheral blood on subjects bearing of hypertrophy without infection (H, n = 83), recurrent tonsillitis (RA, n = 75), and peritonsillar abscess (PA, n = 12). SOD levels in both tonsillar cultures supernatants and peripheral blood erythrocytes were detected progressively increased in groups with H, RA and PA, which were statistically significative (ANOVA-test; p < 0.001). A significative correlation between tissue and blood was observed for all the groups. We can conclude that SOD concentration in palatine tonsils and/or peripheral blood increases proportionally to infections incidence, which allows detecting patients with functional damage, and recommending objectively tonsillectomy or at least monitoring clinical response for a therapy. Practical use and results obtained from comparison to tonsil biopsies are discussed.
Servicio de ORL, Hospital Clínico Universitario, Valencia.
F J
FJ
García Callejo
L
L
Blay Galaud
A
A
Platero Zamarreño
M M
MM
Velert Vila
I
I
Mallea Cañizares
J
J
Marco Algarra
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D006984:Hypertrophy; D008875:Middle Aged; D014066:Palatine Tonsil / Q000201:enzymology* / Q000473:pathology / Q000601:surgery; D013482:Superoxide Dismutase / Q000032:analysis* / Q000097:blood; D014068:Tonsillectomy
D015415:Biomarkers; D013482:Superoxide Dismutase