Significant correlation between expression of interleukin-1alpha and liver metastasis in gastric carcinoma.
BACKGROUND
Interleukin (IL)-1 has been reported to augment the hematogeneous metastasis of some cancers by inducing the expression of adhesion molecules on vascular endothelial cells and also increasing the expression of proteases from tumor cells in vitro. The purpose of this study was to determine the clinical significance of the IL-1alpha expression in primary tumors of gastric carcinoma.


METHODS
Paraffin embedded sections of the tumors obtained from 109 patients who underwent a gastrectomy for gastric carcinoma with subserosal invasion were stained for IL-1alpha by using the streptavidin biotin method. Staining was considered positive when 10% or more of the malignant cells displayed cytoplasmic staining.


RESULTS
Sixty (55.0%) tumors expressed IL-1alpha. Positive staining for IL-1alpha was more likely in patients with differentiated tumors than in those with undifferentiated tumors. The expression of IL-1alpha showed a significant correlation with liver metastasis. Of the 84 patients receiving a curative resection, those with tumors expressing IL-1alpha had a significantly higher incidence of liver recurrence than those without. A logistic regression analysis revealed positive staining for IL-1alpha to be the best predictive factor of patients who develop liver recurrence.


CONCLUSIONS
The authors' results suggest that the immunohistochemical expression of IL-1alpha is a useful predictor of liver recurrence in patients undergoing a curative resection for gastric carcinoma with subserosal invasion.
First Department of Surgery, National Defense Medical College, Tokorozawa Japan. surg1@ndmc.ac.jp
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Tomimatsu
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Ichikura
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Mochizuki
D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000378:metabolism / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D005743:Gastrectomy; D006801:Humans; D007150:Immunohistochemistry; D007375:Interleukin-1 / Q000378:metabolism*; D008113:Liver Neoplasms / Q000556:secondary*; D016015:Logistic Models; D008197:Lymph Node Excision; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D013274:Stomach Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate
D014408:Biomarkers, Tumor; D007375:Interleukin-1