[Role of estrogens in the regulation of puberty in female rats].
Various correlations of testosterone metabolites during puberty were modulated in female rats. It has been fixed that estrogenes stimulate female pubescence only under conditions of non-aromatized androgenes availability in organism. Role of estrogenes in first-stage puberty (vagina opening) consists in activation of fermentative (5a-reductive) system which realises testosterone biotransformation into 5 alpha-reduced androgenes. Being dependent on the dose estrogenes shorten the period between initial and final (establishing positive feed-back way in ovaries-hypophysis system) puberty stages, hasten the first ovulation.
Ukrainian Research Institute of Pharmacotherapy of Endocrine Diseases, Kharkov, Ukraine.
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LB
Litvinova
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D000818:Animals; D004789:Enzyme Activation; D005260:Female; D010053:Ovary / Q000201:enzymology / Q000378:metabolism; D010060:Ovulation; D051381:Rats; D012741:Sexual Maturation / Q000502:physiology; D013739:Testosterone / Q000378:metabolism*
D013739:Testosterone; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase