[A study on enzymatic activities of bronchoalveolar lavage fluid in patients with interstitial lung diseases].
OBJECTIVE
To evaluate the relationship between enzymatic activities in bronchoalveolar lavage fluid(BALF) and interstitial lung diseases(ILDs).


METHODS
Cellular components and levels of superoxide dismutase (SOD), glutathione peroxidase(GSH-PX), angiotensin converting enzyme(ACE) and lactate dehydrogenase(LDH) in BALF in 30 cases of ILDs: including 18 patients with idiopathic pulmonary fibrosis (IPF) and 12 patients with sarcoidosis (Sarc) and 9 healthy controls were determined.


RESULTS
(1) The levels of BALF-SOD, GSH-PX were significantly decreased(P < 0.01), and BALF-ACE, LDH were markedly increased (P < 0.05) in patients with IPF, and BALF-ACE were also increased in patients with Sarc(P < 0.05); (2) There were good correlation between ACE and percentage of lymphocyte (r1 = 0.6574, P < 0.05), and ratio of CD4+/CD8+ (r2 = 0.9544, P < 0.001) in BALF of Sarc group.


CONCLUSIONS
Determining enzymatic activities could be helpful to study pathogenesis and diagnosis of ILDs, BALF-ACE may be as a good marker of disease activity of Sarcoidosis.
Affiliated ZhongShan Hospital of Shanghai Medical University, Shanghai 200032.
J
J
Zheng
Y
Y
Jia
K
K
Zhou
D000328:Adult; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000201:enzymology*; D017565:Sarcoidosis, Pulmonary / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism
D007770:L-Lactate Dehydrogenase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D007703:Peptidyl-Dipeptidase A