Induction of hepatitis B virus-specific cytotoxic T lymphocytes response in vivo by filamentous phage display vaccine.
The ability of inducing MHC class I restricted cytotoxic T lymphocytes response in vivo via recombinant filamentous phage was investigated. The recombinant filamentous phage particles that displayed the Hepatitis B virus epitope S(28--39) were injected into BALB/c (H-2d) mice without adjuvants. A MHC class I restricted HBs specific CTL response was found 8 days after injection. The potentiality of using the recombinant filamentous phage as anti-virus vaccine was discussed.
Wan
Y
Y
The Institute of Immunology, The Third Military Medicine University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, People's Republic of China. a65428305@public.cta.cq.cn
Wu
Y
Y
Bian
J
J
Wang
X Z
XZ
Zhou
W
W
Jia
Z C
ZC
Tan
Y
Y
Zhou
L
L
D000818:Animals; D001483:Base Sequence; D005260:Female; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006515:Hepatitis B virus / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology*; D019151:Peptide Library; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*
D017325:Hepatitis B Vaccines; D015395:Histocompatibility Antigens Class I; D010446:Peptide Fragments; D019151:Peptide Library; D014614:Vaccines, Synthetic