Cbl: many adaptations to regulate protein tyrosine kinases.
Responses to extracellular stimuli are often transduced from cell-surface receptors to protein tyrosine kinases which, when activated, initiate the formation of protein complexes that transmit signals throughout the cell. A prominent component of these complexes is the product of the proto-oncogene c-Cbl, which specifically targets activated protein tyrosine kinases and regulates their signalling. How, then, does this multidomain protein shape the responses generated by these signalling complexes?
Thien
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CB
Department of Pathology, University of Western Australia, 35 Stirling Highway, Crawley, Western Australia 6009, Australia.
Langdon
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WY
D000199:Actins / Q000378:metabolism; D000818:Animals; D029742:Caenorhabditis elegans Proteins; D003599:Cytoskeleton / Q000378:metabolism; D015536:Down-Regulation; D004627:Embryonic Induction; D015801:Helminth Proteins / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008958:Models, Molecular; D050722:Oncogene Protein v-cbl; D017434:Protein Structure, Tertiary; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D050721:Proto-Oncogene Proteins c-cbl; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism; D015682:Retroviridae Proteins, Oncogenic / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000502:physiology; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism
D000199:Actins; D029742:Caenorhabditis elegans Proteins; D015801:Helminth Proteins; C000715470:MAS1 protein, human; D050722:Oncogene Protein v-cbl; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D015682:Retroviridae Proteins, Oncogenic; C095237:Sli-1 protein, C elegans; D014452:Ubiquitins; D050721:Proto-Oncogene Proteins c-cbl; D044767:Ubiquitin-Protein Ligases; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; C067419:CBL protein, human; C493849:Cbl protein, mouse