Varicella vaccine in post-exposure prophylaxis.
Evidence concerning the effectiveness of Oka-based varicella vaccines when administered following exposure to varicella zoster virus in domestic and hospital settings is reviewed. The evidence appears to support post-exposure use of Oka-derived varicella vaccines in children within 3 days of rash onset in the index case. Despite vaccination, a small proportion will develop mild, but infectious, chickenpox, especially if they have been exposed in the household setting. Controlled studies of post-exposure prophylaxis in adults using both Varilrix and Varivax II are still needed. The applicability of this approach to disease control in health care facilities and in community settings warrants wider discussion.
South Eastem Sydney Public Health Unit, Locked Bag 88, Randwick, NSW, Australia 2031. fersonm@sesahs.nsw.gov.au
M J
MJ
Ferson
D001315:Australia / Q000453:epidemiology; D002644:Chickenpox / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission*; D019433:Chickenpox Vaccine / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D016032:Randomized Controlled Trials as Topic; D012680:Sensitivity and Specificity; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage
D019433:Chickenpox Vaccine; D014613:Vaccines, Attenuated