[The study of PCNA expression and AgNORs counting adult-onset laryngeal papilloma].
Avidin-Biotin-peroxidase Complex technique (ABC) and silver staining technique were used to study the relationship between proliferative activity and the biological status of adult-onset laryngeal papilloma. The proliferating index of PCNA positive cells was closely related to AgNORs count. The two indices were significantly different among these groups (P < 0.05).


CONCLUSIONS
PCNA expression and AgNORs count are useful in distinguishing between benign and malignant laryngeal neoplasms, monitoring premalignancy and observing tumor biological activity.
Department of Otorhinolaryngology, Second Clinical Hospital, China Medical University, Shenyang 110003.
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D002471:Cell Transformation, Neoplastic; D006801:Humans; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology; D009687:Nuclear Proteins / Q000032:analysis; D009697:Nucleolus Organizer Region / Q000737:chemistry; D010212:Papilloma / Q000737:chemistry* / Q000473:pathology; D011230:Precancerous Conditions / Q000737:chemistry* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D016622:Silver Staining
D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen