Topical permethrin exposure inhibits antibody production and macrophage function in C57Bl/6N mice.
Permethrin was applied to the shaved dorsal interscapular region of C57Bl/6N mice at doses of 0.5, 1.5 or 5.0 microl/day. These doses corresponded to approximately 22-220 mg/kg/day topical insecticide. Mice were exposed to permethrin in this manner daily for 10 or 30 consecutive days, or every other day for 7 or 14 exposures. The splenic macrophage chemiluminescent response was depressed in a dose-dependent manner at 2 and 10 days post-exposure to permethrin. Phagocytic ability of macrophages was not inhibited. Antibody production as shown by plaque-forming cell (PFC) assay decreased significantly after 10 consecutive days of exposure to permethrin. These data indicate that topical permethrin exposure may produce systemic immune effects.
Punareewattana
K
K
Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061-0442, USA.
Smith
B J
BJ
Blaylock
B L
BL
Longstreth
J
J
Snodgrass
H L
HL
Gogal
R M
RM
Prater
R M
RM
Holladay
S D
SD
D000287:Administration, Topical; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006462:Hemolytic Plaque Technique; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008163:Luminescent Measurements; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D026023:Permethrin; D010587:Phagocytosis / Q000187:drug effects; D011722:Pyrethrins / Q000008:administration & dosage / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects / Q000276:immunology
D007306:Insecticides; D011722:Pyrethrins; D026023:Permethrin