AKAP signaling complexes at the cytoskeleton.
Targeting of protein kinases and phosphatases to the cytoskeleton enhances the regulation of signal transduction events. The assembly of cytoskeletal signaling complexes facilitates the relay of messages from membrane receptors to specific sites on the actin cytoskeleton. These signals influence fundamental cell properties, such as shape, movement and division. Targeting of the cAMP-dependent kinase (PKA) to the cytoskeleton is achieved through interaction with A-kinase anchoring proteins (AKAPs). AKAPs maintain multivalent signaling complexes by binding additional enzymes, including kinases and phosphatases.
Diviani
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Howard Hughes Medical Institute and Vollum Institute, Oregon Health Sciences University, Portland, Oregon, USA.
Scott
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JD
D054758:A Kinase Anchor Proteins; D000199:Actins / Q000737:chemistry / Q000378:metabolism; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D000941:Antigens / Q000737:chemistry / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D018797:Cell Cycle Proteins; D018385:Centrosome / Q000378:metabolism* / Q000648:ultrastructure; D017868:Cyclic AMP-Dependent Protein Kinases / Q000737:chemistry / Q000378:metabolism*; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008869:Microtubule-Associated Proteins / Q000737:chemistry / Q000378:metabolism; D008870:Microtubules / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology; D051316:Wiskott-Aldrich Syndrome Protein
D054758:A Kinase Anchor Proteins; C491162:AKAP12 protein, human; C484688:AKAP2 protein, human; C119719:AKAP9 protein, human; D000199:Actins; D048868:Adaptor Proteins, Signal Transducing; D000941:Antigens; D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D008869:Microtubule-Associated Proteins; D011506:Proteins; C495767:WAS protein, human; D051316:Wiskott-Aldrich Syndrome Protein; C086178:pericentrin; D017868:Cyclic AMP-Dependent Protein Kinases