Recombinant granulocyte colony-stimulating factor (G-CSF) in infectious diseases: still a debate.
Granulocyte colony-stimulating factor (G-CSF), a central mediator of the endogenous response to infection and inflammation, is approved for use in the prevention of infection-related complications in patients with nonmyeloid malignancies during antineoplastic therapy associated with high risk of severe neutropenia. Administration of granulocyte colony-stimulating factor results in improvement of host defence paired with anti-inflammatory effects. There is evidence from animal and clinical studies that administration of granulocyte colony-stimulating factor may also be beneficial in non-neutropenic infections. This review focuses mainly on the results of different animal and clinical studies of granulocyte colony stimulating factor used in the treatment of severe infections and sepsis.
Division of General and Surgical Intensive Care Medicine, Department of Anaesthesia and Intensive Care Medicine, Leopold-Franzens-University of Innsbruck, Austria.
F J
FJ
Wiedermann
M
M
Mittermayr
G
G
Hoffmann
W
W
Schobersberger
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D001930:Brain Injuries / Q000150:complications; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D006168:Guinea Pigs; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology; D010919:Placebos; D018410:Pneumonia, Bacterial / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D011994:Recombinant Proteins; D012128:Respiratory Distress Syndrome / Q000150:complications; D012307:Risk Factors; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology; D012756:Sheep; D012771:Shock, Hemorrhagic / Q000188:drug therapy; D012772:Shock, Septic / Q000188:drug therapy; D013552:Swine
D000900:Anti-Bacterial Agents; D010919:Placebos; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim