Innate cytokine profile in patients with complex regional pain syndrome is normal.
Complex regional pain syndrome (CRPS) is a disabling disease characterized by the classic symptoms and signs of inflammation. In this study we investigated the innate cytokine profile in patients with CRPS to determine a possible role of the immune system in the pathophysiology of CRPS. The cytokine profile before and after lipopolysaccharide and thrombin stimulation was determined in 26 severely affected CRPS patients and 20 healthy controls. No difference in the production of pro- and anti- inflammatory cytokines between patients and controls was found. Hence, our results do not support a role of genetic factors responsible for the cytokine profile in the pathophysiology of CRPS. These findings encourage further investigations of mechanisms responsible for neurogenic-induced inflammation.
Department of Neurology, Leiden University Medical Center, Leiden, The Netherlands Department of Gerontology, Leiden University Medical Center, Leiden, The Netherlands Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands.
W J T
WJT
van de Beek
E J
EJ
Remarque
R G J
RGJ
Westendorp
J J
JJ
van Hilten
D000293:Adolescent; D000328:Adult; D000368:Aged; D020918:Complex Regional Pain Syndromes / Q000097:blood* / Q000276:immunology*; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D013917:Thrombin / Q000494:pharmacology
D016207:Cytokines; D008070:Lipopolysaccharides; D013917:Thrombin