Does concommitant splenectomy raise the mortality of liver transplant recipients?
Within a 17-month period, 130 orthotopic liver transplantations were performed in our hospital. Nine of these were retransplantations and were not included in our analysis. In the remaining 121 patients, splenectomy was performed in 34 patients, either synchronously with the transplant procedure (27 patients) or in the postoperative period (7 patients). Indications for splenectomy were lienalis-steal syndrome in 15 patients and hypersplenism in 15 cases. The number of rejection episodes was fairly equal in both groups (splenectomized vs. non-splenectomized, 61.7% vs. 63.9%, respectively). There was a marked difference in the frequency of infectious episodes (61.7% vs. 25.3%) that resulted in a decreased survival rate (77.5% vs. 95.4%) for splenectomized patients. Therefore, we recommend splenectomy only for very selected patients and investigate the banding of the splenic artery as an alternative.
Lüsebrink
R
R
Department of Surgery, University Hospital Rudolf Virchow, Free University of Berlin, Germany.
Blumhardt
G
G
Lohmann
R
R
Bachmann
S
S
Knoop
M
M
Lemmens
H P
HP
Neuhaus
P
P
D005260:Female; D006801:Humans; D007239:Infections / Q000453:epidemiology; D016031:Liver Transplantation / Q000401:mortality*; D008297:Male; D011183:Postoperative Complications / Q000453:epidemiology; D012086:Reoperation; D012189:Retrospective Studies; D013156:Splenectomy / Q000009:adverse effects / Q000401:mortality; D013158:Splenic Diseases / Q000150:complications / Q000601:surgery; D013163:Splenomegaly / Q000150:complications / Q000601:surgery; D015996:Survival Rate