Study of inflammatory responses to crocidolite and basalt wool in the rat lung.
The subacute effects of crocidolite and basalt wool dusts were studied by nmeans of biochemical, morphological. and histological methods 1 and .3 mo after intrabronchial instillation. The cell count, protein and phospholipid contents, and lactate dehydrogenase (LDH) activity were determined in the bronchoalveolar lavage (BAL). Both types of fibers induced a prolonged inflammatory reaction in the lung. All the parameters studied in the experimental groups were more markedly elevated after 3 mo. Relative to the control, the protein and LDH values were increased three- to fivefold, the phospholipid content twofold, and the number of free cells in the BAL exceeded the control level up to ninefold. The inflammatory responses to crocidolite and basalt wool in the lung did not differ significantly. In spite of this, basalt wool is recoinmended as an asbestos substitute, as the use of this man-nade fiber may result in a significantly lower release of dust than that from crocidolite.
National Institute of Chemical Safety of József Fodor National Center for Public Health, Budapest, Hungary.
Z
Z
Adamis
T
T
Kerényi
K
K
Honma
M
M
Jäckel
E
E
Tátrai
G
G
Ungváry
D000818:Animals; D017638:Asbestos, Crocidolite / Q000633:toxicity*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D003252:Construction Materials / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008168:Lung / Q000473:pathology*; D008297:Male; D008903:Minerals / Q000633:toxicity*; D010743:Phospholipids / Q000378:metabolism; D011014:Pneumonia / Q000139:chemically induced / Q000473:pathology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D017640:Silicates / Q000633:toxicity*
D008903:Minerals; D010743:Phospholipids; D011506:Proteins; D017640:Silicates; C060346:basalt; D017638:Asbestos, Crocidolite; D007770:L-Lactate Dehydrogenase