Platelet-specific alloantigens in cadaveric renal transplantation. A prospective study. Effect of HPA-5b mismatch in acute vascular rejection of renal allografts.
This prospective study comprised 166 renal allograft-recipient pairs that were studied for human platelet alloantigens (HPA) 1-3 and 5, which have been shown to be expressed by adhesion molecules of the vascular endothelium. Four of the five (80%) HPA-5a5a regraft recipients developing acute vascular rejection (AVR) had received an HPA-5b-incompatible graft in contrast to one of the 32 (3%) regraft recipients without rejection. The occurrence of AVR was not explained by the degree of HLA mismatches. All four regraft recipients of an HPA-5b-mismatched graft with AVR were HLA-A3,B7, and the combination of HLA-A3 and/or B7 match and an HPA-5b-mismatched graft was associated with AVR. No antibodies against HPA-5b were detected in the patients with AVR of an HPA-5b-mismatched graft. These preliminary findings suggest that HPA-5b is a minor histocompatibility antigen involved in the development of AVR.
Kekomäki
S
S
Finnish Red Cross Blood Transfusion Service, Helsinki, Finland.
Kyllönen
L
L
Salmela
K
K
Koskimies
S
S
Kekomäki
R
R
D000208:Acute Disease; D016824:Antigens, Human Platelet / Q000276:immunology*; D001323:Autoantibodies / Q000097:blood; D004730:Endothelium, Vascular / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000276:immunology / Q000601:surgery; D016030:Kidney Transplantation / Q000276:immunology*; D011446:Prospective Studies
C055973:5b alloantigen, human; D016824:Antigens, Human Platelet; D001323:Autoantibodies; D000939:Epitopes