[Early cellular immune response in experimental labyrinthitis: immunohistochemical study].
Labyrinthitis ossificans is a recently recognized entity with the extending cochlear implant surgery. Up to date there are not so many studies of the cellular response leading the organization of the inflammatory reaction within the cochlea. Immunemediated labyrinthitis is a valid experimental model that allow the knowledge of the cellular infiltration mechanisms within the cochlea. The inner ear communicates with systemic immunity via the circulation by the passage of cells through the spiral modiolar vein (SMV) and its collecting venules in the scala tympani. Inflammatory reaction within the cochlea lead to the formation of fibrotic tissue and bone (osteoneogenesis) inside it and injuring the neurosensory organs of hearing and balance. To test which cells are proliferating early in an inflammatory response, an animal model of Keyhole limpet haemocyanin (KLH) induced labyrinthitis was utilized, showing a granulomatous lesions not previously reported in this experimental model.
García Berrocal
J R
JR
Servicio de ORL, Clínica Puerta de Hierro, San Martín de Porres, 4, 28035 Madrid.
Ramírez-Camacho
R
R
Zurita
M
M
Arellano
B
B
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000502:physiology; D007762:Labyrinthitis / Q000276:immunology*