[Study on the pathogenesis of free radical in nocturnal asthma].
OBJECTIVE
To examine the relationship between the pathogenesis of nocturnal asthma and free radicals.


METHODS
The changes of the chemiluminescence of lymphocytes (Ly-cl) and polymorphonuclear leukocytes (PMN-cl) were studied by the cell chemiluminescence method. Glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) levels also were determined respectively.


RESULTS
The Ly-cl and PMN-cl in patients with nocturnal asthma on the second day 2:00 am were significantly higher than that of the second day 2:00 pm (P < 0.01) and higher than that of normal group (P < 0.01). The GSH-px were decreased and MDA were increased, and there were significant differences compared with normal group (P < 0.001, P < 0.01 respectively).


CONCLUSIONS
There is an obvious difference on metabolism of free radicals on day and night in nocturnal asthma. The results support that the free radicals have an important role in pathogenesis of nocturnal asthma.
Uighur Medical Inistitute of Xinjiang, Wurumuqi 830001.
Hamulati
Abuduaini
Abudureyimu
D000328:Adult; D001249:Asthma / Q000097:blood* / Q000473:pathology; D002940:Circadian Rhythm; D005260:Female; D005609:Free Radicals / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood*; D006801:Humans; D008163:Luminescent Measurements; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D009504:Neutrophils / Q000737:chemistry
D005609:Free Radicals; D008315:Malondialdehyde; D005979:Glutathione Peroxidase