Effect of endothelin-1 on DNA synthesis in the myocardium of albino rats during early postnatal ontogeny.
Effect of intraperitoneal injection of endothelin-1 on DNA synthesis in the myocardium of newborn albino rats was studied by(3)H-thymidine autoradiography. Endothelin-1 injected in a single dose of 10 microg/kg stimulated proliferative processes: the index of labeled nuclei and labeling intensity increased. Repeated (5 times) administration of endothelin-1 in doses of 1 and 10 microg/kg increased labeling intensity, but did not change the index of labeled nuclei. The data suggest that endothelins are involved in morphogenesis of the myocardium during the early postnatal ontogeny.
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk.
E N
EN
Sazonova
O A
OA
Sazonov
O A
OA
Lebed'ko
V M
VM
Pikalova
S S
SS
Timoshin
A Y
AY
Rubina
D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D019332:Endothelin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000254:growth & development; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D013936:Thymidine / Q000378:metabolism
D019332:Endothelin-1; D004247:DNA; D013936:Thymidine