Movement and deposition of two organophosphorus pesticides within a residence after interior and exterior applications.
Post-application temporal and spatial distributions of two organophosphorus pesticides, diazinon (O,O-diethyl O-[6-methyl-2-(1-methylethyl)-4-pyrimidinyl] phosphorothioate, CAS No. 333-41-5) and chlorpyrifos [O,O-diethyl-O-(2-isopropyl-6-methyl-4-pyrimidinyl) phosphorothioate, CAS No. 2921-88-2], were monitored after homeowner applications for indoor and outdoor insect control. Samples of indoor air, vacuumable carpet dust, carpet dislodgeable residues, deposits on bare floors, table tops and dinnerware, surrogate food, and residues on children's hands and toys were taken before and up to 12 days after treatments in the family room, kitchen, and child's bedroom. Results from the study demonstrate the nature and magnitude of translocation of pesticides from the areas of application to surfaces accessible for human contact and permit comparisons of potential exposures via respiration and dermal contact/oral ingestion. Potential indoor inhalation exposures were estimated to be as high as 0.5 microg/kg/day for diazinon applied indoors and 0.05 microg/kg/day for chlorpyrifos applied to the outside perimeter of the house. While ingestion of carpet dust at the rate of 100 microg/day would have added a maximum of only approximately 0.01 microg/kg/day to the daily dose, residues found on the children's hands suggest that repeated mouthing could have contributed as much as 1-1.5 microg/kg/day. These estimates are below the U.S. Environmental Protection Agency (EPA) reference dose for chlorpyrifos, but exceed those for diazinon.
Lewis
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RG
U.S. Environmental Protection Agency, National Exposure Research Laboratory, Research Triangle Park, North Carolina 27711, USA. lewis.bob-dr@epa.gov
Fortune
C R
CR
Blanchard
F T
FT
Camann
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DE
D000279:Administration, Cutaneous; D000284:Administration, Oral; D016902:Air Pollution, Indoor / Q000009:adverse effects* / Q000032:analysis; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D004391:Dust; D004781:Environmental Exposure / Q000032:analysis*; D005260:Female; D006798:Housing; D006801:Humans; D007223:Infant; D007306:Insecticides / Q000009:adverse effects* / Q000032:analysis / Q000493:pharmacokinetics; D008297:Male; D009943:Organophosphorus Compounds; D010573:Pesticide Residues / Q000032:analysis; D014835:Volatilization
D004391:Dust; D007306:Insecticides; D009943:Organophosphorus Compounds; D010573:Pesticide Residues