Intestinal permeability in strongyloidiasis.
The objective of the present study was to assess intestinal permeability in patients with infection caused by Strongyloides stercoralis. Twenty-six patients (16 women and 10 men), mean age 45.9, with a diagnosis of strongyloidiasis were evaluated. For comparison, 25 healthy volunteers (18 women and 7 men), mean age 44.9, without digestive disorders or intestinal parasites served as normal controls. Intestinal permeability was measured on the basis of urinary radioactivity levels during the 24 h following oral administration of chromium-labeled ethylenediaminetetraacetic acid ((51)Cr-EDTA) expressed as percentage of the ingested dose. The urinary excretion of (51)Cr-EDTA was significantly reduced in patients with strongyloidiasis compared to controls (1.60 +/- 0.74 and 3.10 +/- 1.40, respectively, P = 0.0001). Intestinal permeability is diminished in strongyloidiasis. Abnormalities in mucus secretion and intestinal motility and loss of macromolecules could explain the impaired intestinal permeability.
Werneck-Silva
A L
AL
Laboratório de Investigação Médica (LIM 07), Departamento de Gastroenterologia, Hospital das Clínicas, Universidade de São Paulo, São Paulo, SP, Brasil.
Sipahi
A M
AM
Damião
A O
AO
Buchpigue
C A
CA
Iriya
K
K
Laudanna
A A
AA
D000328:Adult; D000368:Aged; D000818:Animals; D016022:Case-Control Studies; D002860:Chromium Radioisotopes / Q000652:urine; D004492:Edetic Acid / Q000652:urine; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010539:Permeability; D017171:Strongyloides stercoralis; D013322:Strongyloidiasis / Q000503:physiopathology* / Q000652:urine
D002860:Chromium Radioisotopes; D004492:Edetic Acid