[Strategies for the synthesis of nifedipine analog esters of l-ascorbic acid].
The synthesis of L-ascorbyl 4-aryl-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylates was not successful using various modifications. The strategies are shown and 7 new L-ascorbic acid derivatives are synthesized, including the dispiro compound 14.
Institut für Pharmazeutische Chemie der Technischen Universität Braunschweig, Germany. k.goerlitzer@tu-bs.de
K
K
Görlitzer
H J
HJ
Baltrusch
D001205:Ascorbic Acid / Q000737:chemistry*; D002121:Calcium Channel Blockers / Q000138:chemical synthesis*; D013058:Mass Spectrometry; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D002121:Calcium Channel Blockers; D009543:Nifedipine; D001205:Ascorbic Acid