Pulmonary ventilation: dynamic MRI with inhalation of molecular oxygen.
We have recently demonstrated a non-invasive technique to visualize pulmonary ventilation in humans with inhalation of molecular oxygen as a paramagnetic contrast agent. In the current study, T1 shortening of lung tissue by inhalation of oxygen was observed (P<0.001). The T1 values of lung tissue were also correlated with arterial blood oxygen pressure (PaO(2)) in a pig, resulting in excellent correlation (r(2)=0.997). Dynamic wash-in and wash-out MR ventilation images as well as dynamic wash-in wash-out signal intensity versus time curves were obtained. The mean wash-in decay constants were 26.8+/-10.5 s in the right lung, and 26.3+/-9.5 s in the left lung. The mean wash-out decay constants were 23.3+/-11.3 s in the right lung, and 20.8+/-10.5 s in the left lung. Dynamic assessment of pulmonary ventilation is feasible using oxygen-enhanced MR imaging, which could provide dynamic MR ventilation-perfusion imaging in combination with recently developed MR perfusion imaging technique, and thus a robust tool for the study of pulmonary physiology and pathophysiology.
Department of Radiology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA, USA. hatabu@oasis.rad.upenn.edu
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Hatabu
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Tadamura
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Chen
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Stock
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Li
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Prasad
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Edelman
D000818:Animals; D005240:Feasibility Studies; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D023421:Models, Animal; D010100:Oxygen; D012123:Pulmonary Ventilation; D013552:Swine; D014692:Ventilation-Perfusion Ratio
D010100:Oxygen