Anti-dopamine antibodies: effects on behavior in an "open field," pain sensitivity, CNS monoamine content, and functional activity of immunocytes in C57Bl/6 mice.
Single i.p. doses of anti-dopamine antibodies were given to C57Bl/6 mice. This resulted in inhibition of motor activity in a large proportion of the animals in the "open field" test, which lasted five days. Hyperalgesia, detected 1.5 h and 1 day after doses of antibody, was replaced by analgesia on day 5. There was a sharp reduction in the levels of dopamine and its metabolites in the cerebral cortex at 1 and 5 days; the serotonin level was increased 1 day after doses of antibody, and was significantly decreased at 5 days. There was no effect on cells of the immune system. The possible mechanisms of the neurotropic action of these antibodies are discussed.
Science Research Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, Moscow.
N A
NA
Trekova
L A
LA
Vetrilé
L A
LA
Basharova
O I
OI
Mikovskaya
T G
TG
Khlopushina
D000818:Animals; D019138:Antibodies, Blocking / Q000494:pharmacology*; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D015306:Biogenic Monoamines / Q000378:metabolism*; D002490:Central Nervous System / Q000378:metabolism* / Q000502:physiology; D004298:Dopamine / Q000276:immunology*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010146:Pain / Q000523:psychology*; D010147:Pain Measurement / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology
D019138:Antibodies, Blocking; D015306:Biogenic Monoamines; D004298:Dopamine