Interferon activation and innate immunity.
The interferons are a family of cytokine mediators critically involved in alerting the cellular immune system to viral infection of host cells. Interferons not only exhibit important antiviral effects but also exert a key influence on the quality of the cellular immune responses and amplify antigen presentation to specific T cells. Type I interferon (IFN-alpha and IFN-beta) is secreted by virus-infected cells while type II, immune or gamma interferon (IFN-gamma) is mainly secreted by T cells, natural killer (NK) cells and macrophages. Interferons interact with specific cellular receptors, which promote production of second messengers ultimately leading to expression of antiviral and immune modulatory genes. The IFN genes themselves are regulated by transcriptional and posttranscriptional mechanisms including modulation by a family of interferon regulatory factors (IRFs) synthesised by host cells. IFNs activate macrophages, induce B cells to switch immunoglobulin type, alter T helper response, inhibit cell growth, promote apoptosis and induce an antiviral state in uninfected cells. The therapeutic potential of the IFNs is currently the focus of intense attention in a number of virus-associated diseases, tumours and autoimmune disorders.
Terry Fox Molecular Oncology Group, Lady Davis Institute for Medical Research, Montreal, Canada.
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D015088:2',5'-Oligoadenylate Synthetase / Q000502:physiology; D000818:Animals; D000917:Antibody Formation; D017951:Antigen Presentation; D002874:Chromosome Mapping; D004847:Epithelial Cells / Q000378:metabolism; D005347:Fibroblasts / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D007113:Immunity, Innate / Q000502:physiology*; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000145:classification / Q000235:genetics / Q000502:physiology*; D007694:Killer Cells, Natural / Q000378:metabolism; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D017471:Receptors, Interferon / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000378:metabolism; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D014777:Virus Diseases / Q000276:immunology; D019892:eIF-2 Kinase / Q000502:physiology
D007369:Interferon Inducers; D017471:Receptors, Interferon; D014157:Transcription Factors; D007372:Interferons; D011505:Protein-Tyrosine Kinases; D019892:eIF-2 Kinase; D015088:2',5'-Oligoadenylate Synthetase