[Sodium valproate-induced kinky hair].
BACKGROUND
We report a case of acquired progressive kinking hair, a rare pilar dysplasia. This is the first case induced by sodium valproate.


METHODS
A 6-year-old girl, treated with valproate, observed a progressive change in the texture of her hair. They were kinky, lusterless, dry and, under light microscopy, exhibited an aspect of pseudo-pili torti.


CONCLUSIONS
This child had acquired progressive kinking hair syndrome most likely induced by valproate. Five other cases of valproate-induced pilar dysplasia have been reported but without clinical descriptions.


CONCLUSIONS
We propose adding sodium valproate to the list of drugs susceptible of inducing kinky hair syndrome.
Service de Dermatologie, Hôpital Rangueil, Toulouse.
S
S
Caneppele
J
J
Mazereeuw-Hautier
J L
JL
Bonafé
D002648:Child; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D018682:GABA Agents / Q000009:adverse effects*; D006801:Humans; D007706:Menkes Kinky Hair Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D014635:Valproic Acid / Q000009:adverse effects*
D018682:GABA Agents; D014635:Valproic Acid