Cytokines: IL-21 joins the gamma(c)-dependent network?
The discovery of the cytokine IL-21 adds another member to the ever-growing list of small secreted molecules that have potent effects on lymphoid cells. Initial characterization of the IL-21 receptor complex suggests that IL-21 may belong to the cytokine family whose receptors share the common gamma chain, gamma(c).
Vosshenrich
C A
CA
Unité des Cytokines et Développement Lymphoïde, Institut Pasteur, 25 rue du Dr Roux, 75742, Paris, France. vosshenr@pasteur.fr
Di Santo
J P
JP
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D053738:Interleukin-21 Receptor alpha Subunit; D007378:Interleukins / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D053613:Janus Kinase 1; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism / Q000502:physiology; D008894:Milk Proteins; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D018123:Receptors, Interleukin / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D053655:Receptors, Interleukin-21; D050799:STAT5 Transcription Factor; D015398:Signal Transduction / Q000276:immunology*; D015534:Trans-Activators / Q000378:metabolism; D000098546:Interleukin-21
D004268:DNA-Binding Proteins; C508117:IL21R protein, human; D053738:Interleukin-21 Receptor alpha Subunit; D007378:Interleukins; D008894:Milk Proteins; D018123:Receptors, Interleukin; D053655:Receptors, Interleukin-21; D050799:STAT5 Transcription Factor; D015534:Trans-Activators; D011505:Protein-Tyrosine Kinases; C507904:JAK1 protein, human; D053613:Janus Kinase 1; D000098546:Interleukin-21