Blockade of tryptophan catabolism prevents spontaneous tolerogenicity of liver allografts.
Miki
T
T
Thomas E. Starzl Transplantation Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA.
Sun
H
H
Lee
Y
Y
Tandin
A
A
Kovscek
A M
AM
Subbotin
V
V
Fung
J J
JJ
Valdivia
L A
LA
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006084:Graft Rejection; D016031:Liver Transplantation / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D023001:Transplantation Tolerance / Q000276:immunology*; D014184:Transplantation, Homologous; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D014366:Tryptophan Oxygenase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D004791:Enzyme Inhibitors; D014364:Tryptophan; D014366:Tryptophan Oxygenase