Impaired postprandial gastric myoelectrical activity in Chinese patients with nonulcer dyspepsia.
Using a homemade electrogastrography (EGG) system, we studied the characteristics of the myoelectrical rhythm in Chinese patients with nonulcer dyspepsia (NUD). Based on short-term Fourier transformation, recorded slow waves could be automatically analyzed to obtain the following parameters: dominant frequency/power, percent of normal frequency (2-4 cpm), power ratio, etc. EGG parameters, Helicobacter pylori status, histological examination of gastric mucosa, and dyspeptic symptoms were recorded in 27 NUD patients. Compared to 32 healthy controls, the Chinese NUD patients had abnormal postprandial EGG parameters including a lower percentage of regular 2-4 cpm slow waves (70.10 +/- 2.97% vs 79.08 +/- 2.95%, P < 0.05), a lower level of increment of dominant power (0.62, +/- 0.91 vs 3.76 +/- 0.58 dB, P < 0.05), lower power ratio (1.42 +/- 0.28 vs 2.79 +/- 0.39, P < 0.05) and a higher instability coefficient (0.36 +/- 0.03 vs 0.26 +/- 0.03, P < 0.05). However, Helicobacter pylori infection and its associated gastritis did not influence any EGG parameters in NUD patients. Six main dyspeptic symptoms and total symptom score had no correlation with any EGG parameters. In conclusion, Chinese NUD patients may have abnormal postprandial stomach myoelectrical activity, but these EGG abnormalities are not a direct result of Helicobacter pylori infection and its related gastritis and do not contribution to the dyspeptic symptoms.
Department of Medicine and Surgery, Taipei Veterans General Hospital and School of Medicine, National Yang-Ming University, Taiwan.
C L
CL
Lu
C Y
CY
Chen
F Y
FY
Chang
L J
LJ
Kang
S D
SD
Lee
H C
HC
Wu
T S
TS
Kuo
D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002681:China; D004415:Dyspepsia / Q000145:classification / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D004568:Electrodiagnosis / Q000295:instrumentation / Q000379:methods; D005260:Female; D005583:Fourier Analysis; D005746:Gastric Emptying / Q000502:physiology*; D005756:Gastritis / Q000150:complications; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation / Q000379:methods; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D019518:Postprandial Period / Q000502:physiology*; D012720:Severity of Illness Index; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation