Cytokine profiles in drug-naive schizophrenic patients.
A large body of evidence concerning immunological abnormalities in schizophrenic patients seems to suggest a role of the immune system in the multifactorial pathogenesis of schizophrenia. We investigated the production of various cytokines [interleukin (IL)-2, IL-4, IL-10, interferon (INF)-gamma] in drug-free (n=26) and drug-naive (n=7) schizophrenic patients and in healthy controls (n=33). Production of IL-2 and INF-gamma was significantly higher (respectively P=0.021 and P=0.001) in patients than in controls. These findings provide further evidence that immunological abnormalities are present in some schizophrenic patients.
Association for Research on Schizophrenia (A.R.S.), Fondazione Legrenzi, via Francesco Tamagno 5, 20124 Milan, Italy. arsmilano@tiscalinet.it
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Cazzullo
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Sacchetti
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Galluzzo
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Panariello
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Colombo
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Zagliani
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Clerici
D000328:Adult; D016207:Cytokines / Q000097:blood* / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000276:immunology*
D016207:Cytokines