Effects of therapeutic doses of albuterol on beta2-adrenergic receptor density and metabolic changes.
Beta2-agonist drugs at inhaled supratherapeutic doses or when given orally or parenterally alter peripheral lymphocyte beta2-adrenoceptor density (betaAR) and have demonstrable metabolic effects. However, it is not known whether these changes occur at therapeutic inhaled doses. We therefore studied the effects of therapeutic doses of inhaled albuterol in five asthmatic subjects (mean age 23.0+/-2.4 years) and six normal subjects (mean age 28.3+/-3.3 years). Subjects were studied in a randomized, double-blind protocol in which each subject received either inhaled albuterol (270 microg four times daily) for 2 weeks followed by placebo or vice versa in two sequential 2-week periods separated by a 2-week washout period. In the asthmatics, baseline FEV1 increased significantly (p < 0.05) after 2 weeks of inhaled albuterol treatment compared to the initial visit and after 2 weeks of placebo (mean FEV1: 3.2 L+/-0.7 L, 2.9 L+/-0.5 L, and 3.0 L+/-0. 7 L, respectively). Baseline peripheral lymphocyte betaAR was not significantly different (p > 0.05) between the asthmatic (mean: 757+/-176) and normal subjects (mean: 732+/-251). However, in neither group was there any significant change (p > 0.05) in betaAR or plasma potassium, insulin, or glucose, either acutely or after 2 weeks of albuterol therapy. The present study confirms that there is no difference in peripheral lymphocyte betaAR between asthmatic and normal subjects and also shows that at therapeutic doses of inhaled albuterol, there are no significant changes in betaAR or metabolic effects.
Division of Pulmonary and Critical Care Medicine, University of Kentucky Medical Center, Lexington 40536, USA.
M I
MI
Anstead
T A
TA
Hunt
J W
JW
McConnell
N K
NK
Burki
D000318:Adrenergic beta-Agonists / Q000008:administration & dosage*; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy* / Q000378:metabolism* / Q000503:physiopathology; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects*
D000318:Adrenergic beta-Agonists; D018343:Receptors, Adrenergic, beta-2; D000420:Albuterol