A role for lipid rafts in immune cell signaling.
Cross-linking of surface receptors in hematopoietic cells results in the enrichment of these receptors in the rafts along with other downstream signaling molecules. A possible explanation how signal is transduced through the plasma membrane has arisen from the concept of raft. From the study of cellular responses in the plasma membrane which enrich members of the Src-family tyrosine kinase, rafts can function as centers of signal transduction by forming patches. Under physiological conditions, these elements synergize to transduce successfully a signal at the plasma membrane. Rafts are suggested to be important in controlling appropriate protein interactions in hematopoietic cells, and aggregation of rafts following receptor ligation may be a general mechanism for promoting immune cell signaling.
Department of Pathology, National Children's Medical Research Center, Tokyo, Japan.
Y U
YU
Katagiri
N
N
Kiyokawa
J
J
Fujimoto
D000199:Actins / Q000502:physiology; D001402:B-Lymphocytes / Q000502:physiology*; D007108:Immune Tolerance; D008563:Membrane Lipids / Q000502:physiology*; D021962:Membrane Microdomains / Q000276:immunology*; D008565:Membrane Proteins / Q000502:physiology; D010750:Phosphoproteins / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D011947:Receptors, Antigen, B-Cell / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013107:Sphingolipids / Q000378:metabolism; D019061:src-Family Kinases / Q000378:metabolism
D000199:Actins; D008563:Membrane Lipids; D008565:Membrane Proteins; D010750:Phosphoproteins; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D013107:Sphingolipids; D011505:Protein-Tyrosine Kinases; D019061:src-Family Kinases