[Study of nylestriol effect on bone histomorphometric parameters in ovariectomized rats].
OBJECTIVE
To investigate the response of trabecular bone of ovariectomized (OVX) rats to nylestriol.


METHODS
Thirty-three female Wistar rats were randomly divided into three groups, 11 rats in each: nylestriol-treated group (E), OVX and the control (C). The OVX rats were used as a model for osteoporosis. After being fed with nylestriol for 3 months, all rats were sacrificed. The effect of nylestriol on bone microarchitecture and dynamics were studied by bone histomorphometry.


RESULTS
The data suggest that trabecular bone volume, mean trabecular width, density and cortical thickness were remarkably reduced in OVX group (P < 0.05) while tetracycline labeled surface, osteoid surface and bone turnover rate were increased in comparison with that in C group (P < 0.05). The bone turnover rate and trabecular bone volume were improved with the treatment of nylestriol for 3 months in the OVX rats(P < 0.05).


CONCLUSIONS
Trabecular bone volume and bone turnover rate can be improved by 3 month administrations of nylestriol in osteoporotic rat models.
General Hospital, Tianjin Medical University, Tianjin 300052.
M
M
Zhu
Z
Z
Liu
X
X
Zhang
D000818:Animals; D015519:Bone Density / Q000187:drug effects*; D045166:Estradiol Congeners / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D010052:Ovariectomy; D011800:Quinestrol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000473:pathology
D045166:Estradiol Congeners; C010722:nylestriol; D011800:Quinestrol