[Expression and prognostic relation of cathepsin D in non-small cell lung cancer tissues and lymph nodes].
OBJECTIVE
To study the expression and prognostic significance of cathepsin D(CD) in the patients with lung cancer.


METHODS
A rapid immunohistochemical method (streptavidin-peroxidase conjugated method, SP) was used to detect CD expression of the NSCLC patients in 64 cases lung cancer tissues and paired lymph nodes samples.


RESULTS
The results showed positive expression rate of CD was 66% (42/64) in the lung cancer tissues, of which squamous cell cancer was 57% (17/30), adenocarcinoma was 74%(25/34). In the metastatic lymph nodes, the expression of CD was 57%(20/35). Expression of CD was higher in the patients with stage III-IV than in that with stage I-II (P < 0.05), of which was markedly higher in adenocarcinoma with lymph nodes metastasis than in which lymph nodes negative.


CONCLUSIONS
Higher expression of CD is significantly related to the stage of the disease and lymph node metastasis in the adenocarcinoma. The expression of CD may be a good marker of prognosis in NSCLC.
Wang
Z
Z
Cancer Center, Xin Qiao Hospital, Third Medical University of PLA, Chong Qing 400037.
Zhao
X
X
D000230:Adenocarcinoma / Q000737:chemistry; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002289:Carcinoma, Non-Small-Cell Lung / Q000737:chemistry*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry; D002402:Cathepsin D / Q000032:analysis*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000737:chemistry*; D008198:Lymph Nodes / Q000737:chemistry; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D014408:Biomarkers, Tumor; D002402:Cathepsin D