Immunohistochemical detection of tumor suppressor gene p53 protein in feline injection site-associated sarcomas.
Sarcomas associated with injection sites are a rare but important problem in cats. Immunohistochemical detection of p53 protein may correlate to mutation of the p53 tumor suppressor gene, a gene known to be important in oncogenesis. The expression of nuclear p53 protein in 40 feline injection site-assocated sarcomas was examined by immunohistochemical staining. In 42.5% (17/40), tumor cell nuclei were stained darkly; in 20% (8/40), tumor cell nuclei were stained palely; and in 37.5% (15/40), tumor cell nuclei were unstained. Immunohistochemical detection of p53 protein in a proportion of injection site-associated sarcomas suggests that mutation of the p53 gene may play a role in the pathogenesis of these tumors.
Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada. hainesd@duke.usask.ca
P R
PR
Nambiar
M L
ML
Jackson
J A
JA
Ellis
B J
BJ
Chelack
B A
BA
Kidney
D M
DM
Haines
D000818:Animals; D002371:Cat Diseases / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D002415:Cats; D005354:Fibrosarcoma / Q000209:etiology / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics; D007150:Immunohistochemistry / Q000662:veterinary; D009154:Mutation; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000235:genetics*; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary
D016159:Tumor Suppressor Protein p53