[Effect of the IL-6 transfected bone marrow stromal cells on the recovery of hematopoietic functions in bone marrow transplanted mice].
OBJECTIVE
To study the effect of the IL-6 transfected bone marrow stromal cell, QXMSC1 IL-6, on the hematopoietic reconstitution in bone marrow transplanted mice.


METHODS
Bone marrow transplantation model was established by infusing hematopoietic cells combined with QXMSC1 IL-6 into syngeneic recipient mice through the tail vein. CFU-S, CFU-GM, CFU-E, BFU-E, and peripheral blood pictures were assayed.


RESULTS
QXMSC1 IL-6 could increase the CFU-S, CFU-GM, CFU-E and BFU-E yields in BMT mice, and accelerate the recovery of peripheral blood cells.


CONCLUSIONS
QXMSC1 IL-6 can improve the hematopoietic reconstitution in bone marrow transplanted mice.
Department of Immunology, Beijing Medical University, Beijing 100083.
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Qin
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Xie
D000818:Animals; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D018014:Gene Transfer Techniques; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000187:drug effects; D015850:Interleukin-6 / Q000235:genetics* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D017154:Stromal Cells / Q000166:cytology
D015850:Interleukin-6