Methylnitrosourea induction of thymomas in AKR mice requires one or two "hits" only.
Induction of thymomas by methylnitrosourea in many strains of mice requires 3 "hits". AKR mice develop thymomas spontaneously late in life, probably because of their large load of viral leukemia oncogenes. It was expected therefore, and so found, that methylnitrosourea induces thymomas in AKR mice with only 1 or 2 "hits". The viral oncogene therefore appears to function as a dominant "hit" gene cooperating with the chemical carcinogen.
Frei
J V
JV
Department of Pathology, Faculty of Medicine, University of Western Ontario, London, Canada.
D000406:AKR murine leukemia virus / Q000502:physiology*; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced*; D002472:Cell Transformation, Viral / Q000187:drug effects*; D003043:Cocarcinogenesis; D005260:Female; D008770:Methylnitrosourea / Q000633:toxicity*; D051379:Mice; D008806:Mice, Inbred AKR; D009857:Oncogenes; D013945:Thymoma / Q000139:chemically induced* / Q000821:virology; D013953:Thymus Neoplasms / Q000139:chemically induced* / Q000821:virology
D002273:Carcinogens; D008770:Methylnitrosourea