[Cerebrocrast correction of reparative osteogenesis on the background of chronic stress].
Protective action of cerebrokrast--a derivative from 1,4-dihydropyridine--on the processes of reparative osteogenesis in rats in case of combined action of chronic emotional-pain stress and trauma of mandibular was determined. It is stipulated by a antioxidant properties of cerebrokrast, as well as its stabilizing influence on glycoproteins and calcium homeostasis. The redeived data extend the idea about general-metabolic action of the investigated nootrop at the level of the whole organism and testify worthwhile of its use for prophylaxis of extreme conditions.
Dev'iatkina
T O
TO
Ukrainian Medical Dental Academy, Ukrainian Health Protection Ministry, Poltava, Ukraine.
Voloshina
L I
LI
Klusha
V Ie
VIe
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002118:Calcium / Q000378:metabolism; D002908:Chronic Disease; D004095:Dihydropyridines / Q000627:therapeutic use*; D006023:Glycoproteins / Q000378:metabolism; D008338:Mandibular Injuries / Q000188:drug therapy*; D010012:Osteogenesis / Q000187:drug effects*; D018384:Oxidative Stress / Q000502:physiology*; D010146:Pain / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D004095:Dihydropyridines; D006023:Glycoproteins; C073838:2,6-dimethyl-3,5-bis(2'-propoxyethoxycarbonyl)-4-(2''-difluoromethoxyphenyl)-1,4-dihydropyridine; D002118:Calcium