Detection of viral interleukin-6 in Kaposi sarcoma-associated herpesvirus-linked disorders.
Expression of a viral interleukin-6 (vIL-6) has been detected in certain Kaposi sarcoma (KS)--associated herpesvirus positive (KSHV(+)) lesions. The release of vIL-6 systemically and its contribution to the pathogenesis of HIV-related malignancies was studied. Serum vIL-6 was detected in 13 (38.2%) of 34 HIV(+) patients with KS, in 6 (85.7%) of 7 HIV(+) patients with primary effusion lymphoma (PEL) and/or multicentric Castleman disease (MCD), and in 18 (60.0%) of 30 HIV(+), mostly homosexual, individuals without KS, MCD, or PEL. By contrast, serum vIL-6 was detected in only 3 (23.1%) of 13 patients with classic KS, 1 (2.5%) of 40 blood donors from the United States, and 4 (19.0%) of 21 blood donors from Italy. Circulating vIL-6 levels were associated with HIV(+) status (P <.0001). However, within the HIV(+) cohort, serum vIL-6 levels were not associated with the occurrence of KSHV-associated malignancies (P =.43). (Blood. 2001;97:2173-2176)
Medicine Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. aokiy@mail.nih.gov
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Y
Aoki
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Yarchoan
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Wyvill
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S
Okamoto
R F
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Little
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G
Tosato
D019380:Anti-HIV Agents / Q000627:therapeutic use; D000914:Antibodies, Viral / Q000097:blood; D001782:Blood Donors; D016516:CD4-CD8 Ratio; D005871:Castleman Disease / Q000097:blood* / Q000145:classification / Q000453:epidemiology / Q000473:pathology / Q000821:virology; D015897:Comorbidity; D004797:Enzyme-Linked Immunosorbent Assay; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000188:drug therapy / Q000453:epidemiology; D018023:HIV Seronegativity; D006566:Herpesviridae Infections / Q000097:blood* / Q000150:complications / Q000453:epidemiology / Q000821:virology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity* / Q000502:physiology; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D015850:Interleukin-6 / Q000097:blood*; D007558:Italy / Q000453:epidemiology; D007564:Japan / Q000453:epidemiology; D016483:Lymphoma, AIDS-Related / Q000097:blood* / Q000453:epidemiology / Q000821:virology; D012514:Sarcoma, Kaposi / Q000097:blood / Q000453:epidemiology / Q000821:virology; D014481:United States / Q000453:epidemiology; D014764:Viral Proteins / Q000097:blood*; D014779:Virus Replication
D019380:Anti-HIV Agents; D000914:Antibodies, Viral; D007074:Immunoglobulin G; D015850:Interleukin-6; D014764:Viral Proteins