Capitalizing on large-scale mouse mutagenesis screens.
Variation is the crux of genetics. Mutagenesis screens in organisms from bacteria to fish have provided a battery of mutants that define protein functions within complex pathways. Large-scale mutation isolation has been carried out in Caenorhabditis elegans, Drosophila melanogaster and zebrafish, and has been recently reported in the mouse in two screens that have generated many new, clinically relevant mutations to reveal the power of phenotype-driven screens in a mammal.
Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, Texas 77030, USA. mjustice@bcm.tmc.edu
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D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D004195:Disease Models, Animal; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D005821:Genetic Techniques; D006801:Humans; D008297:Male; D051379:Mice / Q000235:genetics*; D016296:Mutagenesis; D015027:Zebrafish / Q000235:genetics