Unexpected cyanosis in the surgical patient.
Benzocaine is a commonly used topical anesthetic present in many over-the-counter preparations. The development of methemoglobinemia, associated with the use of benzocaine, is potentially fatal. Methemoglobinemia remains unresponsive to the administration of oxygen alone and, in fact, results in greater tissue hypoxemia than the usual monitoring techniques indicate. We report two cases of benzocaine-induced methemoglobinemia occurring 3 months apart at the same institution. A brief discussion regarding methemoglobin is presented.
Department of Surgery, Roswell Park Cancer Institute, Elm and Carlton Streets, Buffalo, NY 14263, USA. jlee@prodigy.net
J S
JS
Lee
P A
PA
Mendez
H O
HO
Douglass
D000328:Adult; D000779:Anesthetics, Local / Q000009:adverse effects*; D001566:Benzocaine / Q000009:adverse effects* / Q000627:therapeutic use; D003490:Cyanosis / Q000139:chemically induced*; D004724:Endoscopy / Q000379:methods; D005260:Female; D006801:Humans; D007441:Intubation, Gastrointestinal / Q000379:methods; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000188:drug therapy; D008751:Methylene Blue / Q000627:therapeutic use; D008875:Middle Aged; D010146:Pain / Q000517:prevention & control
D000779:Anesthetics, Local; D008751:Methylene Blue; D001566:Benzocaine