Neurotropic, immunological and gastric effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine in stressed mice.
Previous studies realized in the laboratory have indicated that application of experimental stress (such as unavoidable footshock) induced significant behavioral, gastric and immunological alterations in mice. The aim of this study was to evaluate effects of low doses of Atropa belladonna L., Gelsemium sempervirens L. and Poumon histamine on stress-induced behavioral, immunological and gastric alterations. Locomotor, postural and exploratory activities have been evaluated by two behavioral tests: light/dark box and staircase tests. Immunological studies were investigated to count white blood cells subpopulations (lymphocytes, neutrophils, monocytes and basophils) by coulter counter. The severity of gastric erosions was evaluated by microscopic technique in mice after experimental stress. The results have demonstrated that low doses of G. sempervirens L. and A. belladonna L. had a significant neurotropic and protective effects on behavioral and gastric alterations induced by experimental stress. The immunological protective effects observed were probably induced via their neurotropic effects. The P. histamine showed a significant immunoprotective and gastroprotective effect in mice exposed to experimental stress.
Laboratory of Pharmacology, University of Metz, 57000 Metz, France.
D
D
Bousta
R
R
Soulimani
I
I
Jarmouni
P
P
Belon
J
J
Falla
N
N
Froment
C
C
Younos
D000470:Alkaloids / Q000276:immunology / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001533:Belladonna Alkaloids / Q000276:immunology / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects*; D018655:Lymphocyte Count; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D013315:Stress, Psychological / Q000188:drug therapy* / Q000209:etiology / Q000276:immunology*
D000470:Alkaloids; D001533:Belladonna Alkaloids; D010936:Plant Extracts