Efficient asymmetric epoxidation of alpha,beta-unsaturated ketones using a soluble triblock polyethylene glycol-polyamino acid catalyst.
[reaction: see text]. Polyethylene glycol (PEG)-bound poly-L-leucine acts as a THF-soluble catalyst for the Juliá-Colonna asymmetric epoxidation of enones. Excellent enantioselectivities may be obtained even with short chain length polyleucine. FT-IR investigations have determined that the catalytically active polyleucine components of these copolymers have an alpha-helical structure.
Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, UK.
R W
RW
Flood
T P
TP
Geller
S A
SA
Petty
S M
SM
Roberts
J
J
Skidmore
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M
Volk