Slowing the progression of CHF. Drug therapy to correct neurohormonal abnormalities.
As the population ages, the number of cases of congestive heart failure (CHF) is expected to climb. Primary care physicians will be increasingly called upon to treat patients with this serious cardiac derangement. In this article, Drs Ward and Anderson discuss the latest approaches to treatment, which are based on the current understanding that CHF results from left ventricular dysfunction, which causes a complex activation of multiple neurohormonal reflexes.
University of Chicago Hospitals, USA.
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Ward
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Anderson
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D017677:Age Distribution; D000368:Aged; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D001127:Arginine Vasopressin / Q000187:drug effects / Q000502:physiology; D009320:Atrial Natriuretic Factor / Q000187:drug effects / Q000502:physiology; D018450:Disease Progression; D005194:Family Practice / Q000379:methods*; D006333:Heart Failure / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D006801:Humans; D000451:Mineralocorticoid Receptor Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D011320:Primary Health Care / Q000379:methods*; D012084:Renin-Angiotensin System / Q000187:drug effects / Q000502:physiology; D014481:United States / Q000453:epidemiology; D018487:Ventricular Dysfunction, Left / Q000209:etiology
D000319:Adrenergic beta-Antagonists; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000451:Mineralocorticoid Receptor Antagonists; D001127:Arginine Vasopressin; D009320:Atrial Natriuretic Factor