Synthesis of phenylglycine derivatives as potent and selective antagonists of group III metabotropic glutamate receptors.
The syntheses of a range of ring and alpha-substituted 4-phosphonophenylglycines are described. A brief discussion of the antagonist activities of compounds 4-10 on group I, II and III metabotropic glutamate (mGlu) receptors expressed in the neonatal rat spinal cord is included.
Department of Pharmacology, School of Medical Sciences, Bristol, UK.
S J
SJ
Conway
J C
JC
Miller
P A
PA
Howson
B P
BP
Clark
D E
DE
Jane
D000818:Animals; D018691:Excitatory Amino Acid Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
D018691:Excitatory Amino Acid Antagonists; D018094:Receptors, Metabotropic Glutamate; C102718:metabotropic glutamate receptor 3; C027797:phenylglycine chloride; D005998:Glycine