Quality control in the secretory assembly line.
As a rule, only proteins that have reached a native, folded and assembled structure are transported to their target organelles and compartments within the cell. In the secretory pathway of eukaryotic cells, this type of sorting is particularly important. A variety of molecular mechanisms are involved that distinguish between folded and unfolded proteins, modulate their intracellular transport, and induce degradation if they fail to fold. This phenomenon, called quality control, occurs at several levels and involves different types of folding sensors. The quality control system provides a stringent and versatile molecular sorting system that guaranties fidelity of protein expression in the secretory pathway.
Swiss Federal Institute of Technology (ETH), Institute of Biochemistry, Universitätstrasse 16, CH-8092 Zurich, Switzerland. ari.helenius@bc.biol.ethz.ch
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Helenius
D004721:Endoplasmic Reticulum / Q000378:metabolism*; D030342:Genetic Diseases, Inborn / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D037102:Lectins / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D017510:Protein Folding; D021381:Protein Transport; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*
D006023:Glycoproteins; D037102:Lectins; D018832:Molecular Chaperones; D011506:Proteins