Crushed prednisolone tablets or oral solution for acute asthma?
In a randomised trial, treatment with prednisolone in two formulations (oral solution or crushed tablets) was compared in 78 young children with acute asthma. Prednisolone oral solution was better tolerated than crushed tablets (less vomiting, superior taste); clinical resolution was similar.
Lucas-Bouwman
M E
ME
Department of Paediatrics, Isala klinieken/Weezenlanden Hospital, PO Box 10500, 8000 GM Zwolle, Netherlands.
Roorda
R J
RJ
Jansman
F G
FG
Brand
P L
PL
D000208:Acute Disease; D000284:Administration, Oral; D001249:Asthma / Q000188:drug therapy* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007223:Infant; D008297:Male; D010349:Patient Compliance; D011239:Prednisolone / Q000008:administration & dosage* / Q000009:adverse effects; D012996:Solutions; D013607:Tablets; D013649:Taste; D014839:Vomiting / Q000139:chemically induced
D005938:Glucocorticoids; D012996:Solutions; D013607:Tablets; D011239:Prednisolone