5-HT7 receptor mRNA expression in human trigeminal ganglia.
The present study investigated, by using the method of reverse transcriptase polymerase chain reaction, whether the 5-HT7 receptor mRNA is expressed in human trigeminal ganglia. Trigeminal ganglia were excised post mortem from five human subjects. Oligonucleotide primers were selected based upon unique regions of complementary DNA sequence for the cloned human 5-HT7 receptor. Sequence analysis revealed the presence of a single message that matched the sequence of the cloned human 5-HT7 receptor. The present results may direct future efforts to determine the potential excitatory role of the 5-HT7 receptor in the neuropathological events that develop in migraine headache.
Department of Neurology and Neurosurgery, Montreal Neurological Institute, room 751, 3801 University street, Quebec, H3A 2B4, Montreal, Canada.
J A
JA
Terrón
I
I
Bouchelet
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E
Hamel
D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000378:metabolism; D009778:Occipital Lobe / Q000378:metabolism; D010296:Parietal Lobe / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012668:Trigeminal Ganglion / Q000378:metabolism*
D012333:RNA, Messenger; D011985:Receptors, Serotonin; C104425:serotonin 7 receptor