[Synthesis of 3-carbethoxi-2-phenyl-4-quinolones. Potential antimitotics].
The synthesis of the title compounds involved four main reactions: condensation between the acid chlorides and diethyl malonate to obtain the diethyl benzoylmalonates; transformation of these in diethyl chloroarylidenmalonates; the reaction of the substituted anilines with the chlorinated compounds and finally the thermal cyclization in diphenyl ether.
Laboratorio de Síntesis, Grupo de Productos Naturales, Centro de Química Orgánica, Facultad de Ciencias, Universidad Central de Venezuela.
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Quintero
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Pernía
W J
WJ
Guzmán
C J
CJ
Márquez
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D003078:Colchicine / Q000737:chemistry; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014404:Tubulin / Q000378:metabolism
D000970:Antineoplastic Agents; D011804:Quinolines; D014404:Tubulin; D003078:Colchicine