Leukocytoclastic vasculitis with IgA deposits in angioimmunoblastic T cell lymphoma.
Angioimmunoblastic T cell lymphoma (AILD) is a type of peripheral T cell lymphoma associated with fever and generalized lymphadenopathy. Cutaneous manifestations are seen in approximately 40% of the patients. We report herein a Japanese male patient with AILD associated with generalized purpura. The histology of the purpura included leukocytoclastic vasculitis with IgA deposits, which is rare in this disease. Using in situ hybridization and PCR methods, we showed that the involved lymph node was positive for Epstein-Barr virus and that the purpura was negative.
Department of Dermatology, University of Tokyo, Japan.
M
M
Sugaya
K
K
Nakamura
A
A
Asahina
K
K
Tamaki
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D017931:DNA Primers; D003937:Diagnosis, Differential; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000175:diagnosis* / Q000821:virology; D007070:Immunoglobulin A; D017403:In Situ Hybridization; D016399:Lymphoma, T-Cell / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011241:Prednisone / Q000008:administration & dosage; D011693:Purpura / Q000209:etiology*
D017931:DNA Primers; D007070:Immunoglobulin A; D001761:Bleomycin; D005047:Etoposide; D004317:Doxorubicin; D011241:Prednisone