Trace level determination of perchlorate in water matrices and human urine using ESI-FAIMS-MS.
High-field asymmetric waveform ion mobility spectrometry (FAIMS) separates perchlorate from interfering isobaric ions of bisulfate and dihydrogenphosphate in the gas-phase. The use of a new FAIMS prototype and waveform generator, along with the use of a mixed carrier gas, in this electrospray ionisation (ESI)-FAIMS-mass spectrometry (MS) study gave a detection limit for perchlorate in a relatively "clean" matrix of tap water of 0.050 ppb. Flow injection analysis (FIA) of dilutions of fortified waste water, a fortified river water certified reference material (CRM; SLRS-4, National Research Council of Canada), and a fortified human urine Standard Reference Material (SRM; 2381, National Institute of Standards and Technology) gave detection limits of 0.37 ppb, 0.50 ppb, and 4.8 ppb, respectively, in the undiluted matrices.
Institute for National Measurement Standards, National Research Council of Canada, Ottawa, ON.
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Ells
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Barnett
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Purves
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Guevremont
D004784:Environmental Monitoring; D006801:Humans; D010472:Perchlorates / Q000032:analysis / Q000652:urine*; D012680:Sensitivity and Specificity; D017670:Sodium Compounds / Q000032:analysis / Q000652:urine*; D021241:Spectrometry, Mass, Electrospray Ionization / Q000379:methods*; D014865:Waste Disposal, Fluid; D014874:Water Pollutants, Chemical / Q000032:analysis*; D014881:Water Supply
D010472:Perchlorates; D017670:Sodium Compounds; D014874:Water Pollutants, Chemical; C031068:sodium perchlorate