Transurethral alprostadil for the treatment of erectile dysfunction: results of a multicentre trial.
BACKGROUND
The incidence of erectile dysfunction (ED) has been shown to increase significantly in Singaporean male population. Thus, this prospective study (no controls) assessed the clinical efficacy and safety of a medicated urethral system for erection (MUSE) in Singaporean male patients with a known history of ED.


METHODS
Eighty-six men with a mean age of 55.7 years with differential causes of ED were administered with MUSE in the clinic with a titration adjustment of 4 possible dose regimes (125, 250, 500 and 1000 mcg) till efficacy is achieved. Subsequently, patients were subjected to home treatment for a duration of 3 months.


RESULTS
Sixty per cent of inclinic patients exhibited good responses and were given MUSE for home treatment. The efficacy rate for home treatment was 86%. Overall, the patients (n = 86) had a 51.2% success rate in achieving satisfactory sexual intercourse. Diabetic and psychogenic patients were noted to respond well to MUSE. No severe adverse events were found in this study.


CONCLUSIONS
MUSE showed to be a safe, less invasive, well-tolerated and efficient alternative treatment for ED in Singaporean men.
Division of Urology, Department of Surgery, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119704. surlimk@nus.edu.sg
M K
MK
Li
P H
PH
Lim
M Y
MY
Wong
A
A
Fok
S J
SJ
Chia
D
D
Consigliere
P G
PG
Adaikan
P
P
Moorthy
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000527:Alprostadil / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D016503:Drug Delivery Systems; D007172:Erectile Dysfunction / Q000175:diagnosis / Q000188:drug therapy*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D014521:Urethra; D014665:Vasodilator Agents / Q000008:administration & dosage*
D014665:Vasodilator Agents; D000527:Alprostadil