Pharmacokinetic interactions between sirolimus and cyclosporine exacerbate renal dysfunction.
Division of Immunology and Organ Transplantation, University of Texas-Houston, Houston, Texas, USA.
H
H
Podder
S M
SM
Stepkowski
K
K
Napoli
B D
BD
Kahan
D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000493:pharmacokinetics*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D023421:Models, Animal; D051381:Rats; D020123:Sirolimus / Q000009:adverse effects / Q000493:pharmacokinetics*
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D020123:Sirolimus