Biotransformation of podophyllotoxin to picropodophyllin by microbes.
Biotransformation of podophyllotoxin (PT) by several microbial species has been investigated. Among the fungi tested, it was found that Penicillium strains can isomerize PT to picropodophyllin (PPT) in 8% yield and other strains also transform the substrate into the same product but with lower yield.
Guo
H Z
HZ
School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083, P.R. China.
Guo
D A
DA
Fei
X Y
XY
Cui
Y J
YJ
Zheng
J H
JH
D001711:Biotransformation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010407:Penicillium / Q000378:metabolism*; D011034:Podophyllotoxin / Q000031:analogs & derivatives / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics*
C415032:picropodophyllin; D011034:Podophyllotoxin