[Acute intracranial hypertension and anicteric cholestasis revealing Whipple's disease without digestive involvement].
Whipple's disease is a rare infectious disease with potential central nervous system manifestations and a poor prognosis. We report the case of a young woman who presented with acute intracranial hypertension associated with cholestasis which revealed Whipple's disease without digestive involvement. The diagnosis was supported by the presence of PAS-diastase positive hepatic granulomas. A long course of antibiotics resulted in complete remission of the disease without relapse. An acute neurologic syndrome associated with cholestasis should suggest Whipple's disease.
Fédération d'Hépato-Gastroentérologie et INSERM U-481, Hôpital Beaujon, Clichy.
S
S
Lévy
C
C
Degott
A
A
Redondo
J P
JP
Benhamou
J
J
Bernuau
D000293:Adolescent; D000681:Amylases / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002779:Cholestasis / Q000209:etiology*; D005260:Female; D006099:Granuloma / Q000209:etiology / Q000473:pathology; D006801:Humans; D019586:Intracranial Hypertension / Q000209:etiology*; D008107:Liver Diseases / Q000209:etiology / Q000473:pathology; D008061:Whipple Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D000681:Amylases