Surgical treatment of hypothalamic hamartoma and refractory seizures: a case report and review of the literature.
Refractory gelastic seizures are often associated with hypothalamic hamartoma (HH). Presurgical evaluation in such children often points to a distinct cortical region as the source of the seizures. A case of a child with HH and refractory seizures is presented. Video-EEG monitoring revealed a well-defined epileptic focus in the left frontal region. In accordance with the current understanding of the nature of hamartoma-related seizures, the hamartoma was resected. Follow-up evaluations revealed a marked improvement in seizure frequency and global functioning.
Kramer
U
U
Child Developmental Center and Pediatric Neurology Unit, Tel Aviv Sourasky Medical Center, Tel Aviv, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel. umkramer@netvision.net.il
Spector
S
S
Nasser
W
W
Siomin
V
V
Fried
I
I
Constantini
S
S
D002675:Child, Preschool; D003241:Consanguinity; D003937:Diagnosis, Differential; D004569:Electroencephalography; D020195:Epilepsy, Reflex / Q000209:etiology / Q000235:genetics / Q000601:surgery*; D006222:Hamartoma / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D006801:Humans; D007027:Hypothalamic Diseases / Q000175:diagnosis / Q000235:genetics / Q000601:surgery*; D007031:Hypothalamus / Q000473:pathology / Q000601:surgery; D007845:Laughter; D008279:Magnetic Resonance Imaging; D008297:Male; D013686:Telemetry; D014741:Video Recording