Solution structure of (+)-discodermolide.
[structure: see text]. The solution structure of (+)-discodermolide (1) has been determined via 1- and 2-D NMR techniques in conjunction with Monte Carlo conformational analysis. Taken together, the results demonstrate that in solution (+)-discodermolide occupies a helical conformation remarkably similar to the solid state conformation.
Department of Chemistry, Monell Chemical Senses Center, and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.edu
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Smith
M J
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LaMarche
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Falcone-Hindley
D000473:Alkanes; D000818:Animals; D002219:Carbamates; D007166:Immunosuppressive Agents / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D009010:Monte Carlo Method; D011161:Porifera / Q000737:chemistry*; D011753:Pyrones; D012996:Solutions; D014404:Tubulin / Q000737:chemistry
D000473:Alkanes; D002219:Carbamates; D007166:Immunosuppressive Agents; D007783:Lactones; D011753:Pyrones; D012996:Solutions; D014404:Tubulin; C071229:discodermolide