Newly diagnosed human immunodeficiency virus after sepsis-like reaction of trimethoprim-sulfamethoxazole.
A rare sepsis-like hypersensitivity reaction has been observed in persons with human immunodeficiency virus (HIV) after exposure to trimethoprim-sulfamethoxazole. This reaction most commonly occurs on rechallenge with the drug and is manifested by a syndrome resembling bacterial sepsis. The mechanism of this unusual reaction remains unclear. We describe the first case in which this severe hypersensitivity reaction was the initial manifestation of HIV.
Moran
K A
KA
Department of Infectious Diseases, Walter Reed Army Medical Center, Washington, DC 20307, USA.
Ales
N C
NC
Hemmer
P A
PA
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000209:etiology*; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D018805:Sepsis / Q000175:diagnosis / Q000209:etiology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination