Olanzapine may be an effective adjunctive therapy in the management of acne excoriée: a case report.
BACKGROUND
The self-inflicted dermatoses such as acne excorieé and neurotic excoriations are often chronic, recurring, and resistant to standard dermatologic therapies.


OBJECTIVE
We present a 28-year-old woman with longstanding acne excorieé, whose acne started at age 14 years and was followed by acne excorieé at age 16 years. The patient reported that her acne and self-excoriative behavior were exacerbated by psychological stress. The previously treatment-resistant acne excorieé responded favorably to treatment with the atypical antipsychotic agent olanzapine.


METHODS
The patient was started on olanzapine 2.5 mg at bedtime.


RESULTS
After 4 weeks of therapy with olanzapine she reported a significant decline in her self-excoriative behavior which was associated with an improvement in her acne excorieé. The patient used the olanzapine 2.5 mg for 6 months, during which time she also entered psychotherapy in order to deal with some psychosocial stressors that were exacerbating her self-excoriative behavior. The patient has not experienced a recurrence in her self-excoriative behavior or acne excorieé for 4 months after discontinuing the olanzapine.


CONCLUSIONS
Olanzapine may prove to be a useful adjunctive therapy in some self-induced dermatoses including acne excorieé.
Department of Psychiatry, University of Western Ontario, London, Canada.
M A
MA
Gupta
A K
AK
Gupta
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000523:psychology* / Q000628:therapy; D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D001569:Benzodiazepines; D005260:Female; D006801:Humans; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D016728:Self-Injurious Behavior; D013315:Stress, Psychological / Q000150:complications*
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000077152:Olanzapine