Steroid receptors and metastatic potential in endometrial cancers.
The relative overexpression of estrogen receptor (ER)-alpha exon 5 splicing variant, the disrupted synchronization of ER-beta and ER-alpha expressions, and the suppression of progesterone receptor (PR) form A expression as a transcriptional repressor might be related to metastatic potential of uterine endometrial cancers, leading to poor patient prognosis related to estrogen refractoriness.
Department of Obstetrics and Gynecology, Gifu University School of Medicine, 40 Tsukasa-machi, 500-8705, Gifu City, Japan.
J
J
Fujimoto
H
H
Sakaguchi
I
I
Aoki
S
S
Khatun
H
H
Toyoki
T
T
Tamaya
D017398:Alternative Splicing; D000818:Animals; D016889:Endometrial Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000556:secondary*; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D020033:Protein Isoforms / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism; D011980:Receptors, Progesterone / Q000235:genetics / Q000378:metabolism; D011987:Receptors, Steroid / Q000235:genetics / Q000378:metabolism*
D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D020033:Protein Isoforms; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid