The use of thiopentone/propofol admixture for laryngeal mask airway insertion.
An admixture of thiopentone and propofol was evaluated against propofol for laryngeal mask airway (LMA) insertion. Eighty-one ASA 1 and 2 18- to 65-year-old patients, premedicated with 7.5 mg midazolam orally were assigned randomly to receive either propofol 1% or an admixture of thiopentone and propofol (1.25% and 0.5% respectively), both at a dose of 0.25 ml x kg(-1). Satisfactory conditions for insertion were achieved with the admixture, which was comparable to propofol (73% vs 85%, P>0.05). There was no statistical difference in the incidence or severity of gagging, coughing, inadequate jaw relaxation and laryngospasm. The incidence of hypotension was lower in the admixture group (51% vs 78%, P=0.02). The duration of apnoea was not different between the admixture and propofol group (mean 103s vs 109s respectively, P>0.05). We conclude that thiopentone/propofol admixture can be a suitable alternative to propofol for LMA insertion, producing less hypotension while allowing cost savings of up to 45%. An admixture of thiopentone and propofol (1.25% and 0.5% respectively) can produce suitable conditions compared to propofol 1%, for laryngeal mask insertion. In addition to cost containment, the admixture also produces less hypotension.
Department of Anaesthesia, Pamela Youde Nethersole Eastern Hospital, Chai Wan, Hong Kong, PRC.
K S
KS
Yeo
S W
SW
Kua
G S
GS
Teoh
M K
MK
Onsiong
D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous / Q000009:adverse effects* / Q000191:economics; D001049:Apnea / Q000139:chemically induced; D004311:Double-Blind Method; D016527:Drug Costs; D005260:Female; D005683:Gagging / Q000187:drug effects; D006801:Humans; D017214:Laryngeal Masks; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000009:adverse effects* / Q000191:economics; D013874:Thiopental / Q000009:adverse effects* / Q000191:economics
D019162:Anesthetics, Combined; D018686:Anesthetics, Intravenous; D013874:Thiopental; D015742:Propofol