Managing menopause after breast cancer: balancing risks and benefits.
Many women now survive breast cancer, but find themselves at increased risk of menopausal complications. How to manage menopause after breast cancer is a complex issue, given that estrogen has a role in the development of breast cancer and valid concerns exist about estrogen replacement therapy in patients who have had breast cancer. This article explores the relationship between estrogens and breast cancer and discusses management options for a variety of menopausal complications in breast cancer survivors.
Department of Hematology and Medical Oncology, Cleveland Clinic, Cleveland Clinic Foundation, OH 44195, USA. mooreh1@ccf.org
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D000328:Adult; D019386:Alendronate / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D002116:Calcitonin / Q000627:therapeutic use; D002979:Climacteric / Q000187:drug effects; D015331:Cohort Studies; D004965:Estrogen Antagonists / Q000627:therapeutic use; D015914:Estrogen Replacement Therapy; D005260:Female; D005500:Follow-Up Studies; D006331:Heart Diseases / Q000517:prevention & control; D006801:Humans; D008593:Menopause; D008594:Menopause, Premature; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010024:Osteoporosis / Q000517:prevention & control; D011247:Pregnancy; D020849:Raloxifene Hydrochloride / Q000627:therapeutic use; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D012307:Risk Factors; D020845:Selective Estrogen Receptor Modulators / Q000627:therapeutic use; D013629:Tamoxifen / Q000627:therapeutic use; D013997:Time Factors
D000928:Antidepressive Agents; D018931:Antineoplastic Agents, Hormonal; D004965:Estrogen Antagonists; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D020849:Raloxifene Hydrochloride; D002116:Calcitonin; D019386:Alendronate