[Effect of intraventricular infusion of Licvorin on general convulsive activity of rats].
It was studiet anticonvulsive action of the biopreparation licvorin had been made from a cerebrospinal fluid (CSF) of a cattle on the epiliptic activity provoking by korasol. The preparation was infused intraventriculary. Research showed preparation had the antiepileptic effect. It was manifested by decreasing expressiveness of convulsions, averting of general epileptic fit and mortality. Anticonvulsive action of the biopreparation licvorin was registrated in 2 hours and was achieved maximum effect 24 hours after injection. Anticonvulsive properties of the biopreparation licvorin realized by influence his active factors on structures of a brain, specifically on the GABAdependent systems.
Tkach
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S.I. Georgievs'ki Medical Institute, Crimean State University, Simferopol, Ukraine.
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D002417:Cattle; D002555:Cerebrospinal Fluid / Q000737:chemistry*; D004827:Epilepsy / Q000188:drug therapy*; D018756:GABA Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D007276:Injections, Intraventricular; D010433:Pentylenetetrazole; D051381:Rats; D014020:Tissue Extracts
D000927:Anticonvulsants; D018756:GABA Antagonists; D014020:Tissue Extracts; C452217:licvorin; D010433:Pentylenetetrazole