Targeting double stranded DNA with peptide nucleic acid (PNA).
PNA (peptide nucleic acid) is a DNA mimic with a pseudopeptide (polyamide) backbone which can be used to target double stranded DNA with high sequence specificity. PNA therefore has great potential in the development of biomolecular tools for manipulation of DNA as well as for the development of DNA targeted gene therapeutic drugs. The status of this field is discussed in terms of PNA binding modes and mechanism as well as applications.
Center for Biomolecular Recognition, Department of Medical Biochemistry and Genetics, The Panum Institute, Blegdamsvej 3, Copenhagen N, DK-2200, Denmark. pen@imbg.ku.dk
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Nielsen
D004247:DNA / Q000737:chemistry / Q000378:metabolism*; D015195:Drug Design; D005544:Forecasting; D005821:Genetic Techniques; D015316:Genetic Therapy / Q000379:methods; D009696:Nucleic Acids / Q000737:chemistry*; D009994:Osmolar Concentration; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000378:metabolism*
D009696:Nucleic Acids; D020135:Peptide Nucleic Acids; D004247:DNA