1,8-cineol, a food flavoring agent, prevents ethanol-induced gastric injury in rats.
This study investigated the gastroptrotective effect of 1,8-cineole (cineole) on ethanol-induced gastric mucosal damage in rats and the possible mechanisms involved. 1,8-Cineole (50-200 mg/kg), given orally 1 hr before administration of 1 ml of absolute ethanol significantly attenuated the ethanol-induced gastric injury in a manner similar to nordihydroguairetic acid, a known lipoxygenase inhibitor. 1,8-Cineole showed a tendency to restore the ethanol-associated decreases in nonprotein sulfhydryls, suggesting a possible antioxidant effect. In gastric secretion studies, 1,8-cineole, similar to cimetidine, a known histamine-2 receptor antagonist, demonstrated significant inhibitions of both gastric juice volume as well as total acid output. The protection offered by 1,8-cineole was found to be unaltered by 8-phenyltheophylline or L-NAME, indicating that its effect is not mediated by endogenous adenosine or nitric oxide. These results, taken together with the earlier reports, suggest that the antioxidant and lipoxygenase inhibitory actions of 1,8-cineole are of prime importance in affording gastroprotection against ethanol injury in the rat.
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Brazil.
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D000284:Administration, Oral; D000437:Alcoholism / Q000209:etiology* / Q000517:prevention & control*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D003511:Cyclohexanols; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000009:adverse effects*; D000077591:Eucalyptol; D005421:Flavoring Agents; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005756:Gastritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D008610:Menthol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use*; D039821:Monoterpenes; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes
D000975:Antioxidants; D003511:Cyclohexanols; D005421:Flavoring Agents; D039821:Monoterpenes; D013729:Terpenes; D008610:Menthol; D000431:Ethanol; D019001:Nitric Oxide Synthase; D000077591:Eucalyptol; D019331:NG-Nitroarginine Methyl Ester