[Usefulness of chromosome instability analysis for selecting proper therapy of laryngeal cancer].
A decision concerning of larynx cancer therapy is dependent on such factors as tumour location, its size, histology and occurrence of metastasis. The aim of the paper is to turn attention on usefulness of individual sensitivity of genetic information on mutagen-induced damage. The considerations are based on own author's experience and the literature data. Mutagen sensitivity is estimated by bleomycin test that is a measure of individual resistance to mutagens and carcinogens. The review is focused on DNA and chromosome sensitivity to radiation-induced damage. The attempts to individualize radiotherapy basing on cytogenetic and molecular studies are presented.
Klinika Otolaryngologii Akademii Medycznej im. K. Marcinkowskiego w Poznaniu.
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Dabrowski
D001761:Bleomycin / Q000009:adverse effects*; D002869:Chromosome Aberrations / Q000235:genetics*; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D005820:Genetic Testing; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics* / Q000628:therapy*; D009152:Mutagenicity Tests
D001761:Bleomycin; D004247:DNA