Recurrence risks to sibs of MS index cases: impact of consanguineous matings.
Using population-based data, the authors identified 24 MS index cases whose parents were related. Twenty-two had 67 sibs of whom 6 also had MS, yielding a recurrence risk of approximately 9%, significantly higher than for sibs of MS index cases from nonconsanguineous parents. These findings support the concept that multiple interacting genes increase the risk of MS.
Dessa Sadovnick
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Department of Medical Genetics, University of British Columbia, Vancouver, Canada. sadovnik@infinet.net
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D003241:Consanguinity; D006801:Humans; D009103:Multiple Sclerosis / Q000235:genetics* / Q000503:physiopathology*; D009679:Nuclear Family; D012008:Recurrence; D012307:Risk Factors