Mechanisms of taurine antihypoxic and antioxidant action.
The study was undertaken to elucidate the effects of taurine on lipid peroxidation (LP) intensity and membrane Na+, K+-ATPase activity in a hypoxic rat model. It was shown that 3 intraperitoneal (i.p.) injections of 200 mg/kg of taurine prevented hypoxia-induced lactate accumulation and LP in brain, liver, and heart tissues and prevented the decrease of Na+, K+-ATPase activity in the liver. It is suggested that the effect of taurine on LP could be due to the taurine antiacidotic action as well as to its membrane stabilizing activity.
Department of Hypoxia, Bogomoletz Institute of Physiology, Kiel, Ukraine. sereb@mail.kar.net
I N
IN
Mankovskaya
T V
TV
Serebrovskaya
R J
RJ
Swanson
G L
GL
Vavilova
O N
ON
Kharlamova
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects*; D013654:Taurine / Q000494:pharmacology / Q000627:therapeutic use*; D014018:Tissue Distribution
D000975:Antioxidants; D013654:Taurine; D008315:Malondialdehyde; D000254:Sodium-Potassium-Exchanging ATPase