N-Aminoindoline derivatives as inhibitors of 5-lipoxygenase.
N-Aminoindoline derivatives were prepared and their 5-lipoxygenase inhibitory activities were evaluated in vitro and compared with those of phenidone and NDGA. Compound 4 presents the most effective 5-LO inhibition.
Institut de Chimie Pharmaceutique Albert Lespagnol, Université de Lille 2, France.
C
C
Audouin
N
N
Mestdagh
M A
MA
Lassoie
R
R
Houssin
J P
JP
Hénichart
D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001094:Arachidonate 5-Lipoxygenase / Q000378:metabolism; D006918:Hydroxyurea / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology
D000975:Antioxidants; D007211:Indoles; D016859:Lipoxygenase Inhibitors; D011720:Pyrazoles; C057812:indoline; D001094:Arachidonate 5-Lipoxygenase; C015429:phenidone; C063449:zileuton; D006918:Hydroxyurea