Association of HLA B27 antigen in Indian patients of ankylosing spondylitis and other autoimmune diseases.
One thousand three hundred and forty clinically suspected patients of Ankylosing Spondylitis (AS) and other autoimmune diseases and 5000 controls were studied to detect the association of HLA B27 antigen amongst them. Other alleles studied include HLA B7, B40 (B60), B22(B55), B13, etc. Our findings show a considerable and consistent association of HLA B27 with AS irrespective of the community to which the patient, belonged his hygiene or socio-economic conditions. We also found that people in the age group of 21-39 were the most vulnerable, when number of affected individuals or severity of the disease were taken into consideration. Male members showed a preponderance over females in HLA B27 positivity. Detection of HLA B27 could help in the diagnosis of AS. Patients suffering from other autoimmune diseases such as rheumatoid arthritis, psoriasis, Reiter's syndrome and uveitis and patients with inflammatory bowel disease, colitis, eczema, bacillary or fungal infection were also found to be HLA B27 positive. A study of other alleles shows that even they sometimes associate AS and other autoimmune diseases.
Tissue Typing Laboratory, Medical Research Center and Post Graduate Institute of Medical Sciences, Bombay Hospital, Mumbai 400 020.
S R
SR
Kankonkar
S C
SC
Raikar
S V
SV
Joshi
S J
SJ
Tijoriwala
D000328:Adult; D000367:Age Factors; D001327:Autoimmune Diseases / Q000175:diagnosis* / Q000276:immunology; D015415:Biomarkers / Q000032:analysis; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis*; D006801:Humans; D015994:Incidence; D007194:India; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012737:Sex Factors; D013167:Spondylitis, Ankylosing / Q000175:diagnosis* / Q000276:immunology
D015415:Biomarkers; D015796:HLA-B27 Antigen