[Administration of granulocyte colony-stimulating factor in patients infected with human immunodeficiency virus and prolonged neutropenia].
BACKGROUND
Persistent neutropenia is frequent in HIV infected patients with severe immunodeficiency. G-CSF induces proliferation and differentiation of granulocyte precursors. Our objective has been to assess the response to G-CSF therapy on patients with advanced HIV disease and prolonged neutropenia.


METHODS
A retrospective analysis of databases containing demographic information, analytic controls and hospitalizations related to neutropenia for patients attending our Infectious Diseases Unit from December 1, 1992 to January 30, 98. The episodes with absolute neutrophil counts lower than 1,000 x 10(6)/l at least during 7 days which descend below 500 x 10(6)/l at any moment were included.


RESULTS
36 episodes were included. 9 episodes started on treatment with G-CSF. The median duration was 9 (3-76) weeks. Hospitalization with fever related to neutropenia was significantly less frequent in episodes which received G-CSF (22.2%) than episodes without (66.7%).


CONCLUSIONS
In this study, a significantly lower risk of hospitalization due to fever and neutropenia was associated with administration of G-CSF in patients with absolute neutrophil counts lower than 500 x 10(6)/l.
von Wichmann
M A
MA
Unidad de Enfermedades Infecciosas, Hospital Nuestra Señora de Aránzazu, San Sebastian. vonwichm@chdo.osakidetza.net
Camino
X
X
Txoperena
G
G
Arrizabalaga
J
J
Rodríguez-Arrondo
F
F
Iribarren
J A
JA
D000163:Acquired Immunodeficiency Syndrome / Q000097:blood; D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects; D002454:Cell Differentiation / Q000187:drug effects; D015897:Comorbidity; D004341:Drug Evaluation; D005260:Female; D005334:Fever / Q000209:etiology; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology / Q000627:therapeutic use*; D015658:HIV Infections / Q000097:blood*; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D017053:Infection Control; D007958:Leukocyte Count; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology; D009504:Neutrophils / Q000187:drug effects; D012189:Retrospective Studies; D015819:Substance Abuse, Intravenous / Q000453:epidemiology; D016896:Treatment Outcome
D000890:Anti-Infective Agents; D016179:Granulocyte Colony-Stimulating Factor