Breast carcinomas with immunocytochemical detection of aromatase in fine-needle aspirates: report of three cases.
Three postmenopausal women with breast carcinoma underwent the fine-needle aspiration (FNA) preoperatively, and these specimens were stained by the antiaromatase antibody. We evaluated the identification of the aromatase immunoreactivity in breast carcinoma specimens obtained from both FNA and surgery. FNA specimens showed positive intracellular immunoreactivity of aromatase in these cases. The presence for aromatase in FNA specimens was identified with that in the surgical specimens. To our knowledge, the present cases are the first to report the aromatase staining of FNA specimens. The immunoreactivity of aromatase in FNA specimen may be useful to estimate the effectiveness of new aromatase inhibitors in patients with breast carcinoma. HUM PATHOL 32:348-351.
Tsunoda
Y
Y
Department of Surgery, School of Medicine, Showa University, Tokyo, Japan.
Shimizu
Y
Y
Tsunoda
A
A
Kamiya
K
K
Kusano
M
M
Takimoto
M
M
D000368:Aged; D001141:Aromatase / Q000032:analysis*; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D017698:Postmenopause; D014407:Tumor Cells, Cultured
D001141:Aromatase