A reverse microemulsion polymerization method for preparation of bioadhesive polyacrylic acid nanoparticles for mucosal drug delivery: loading and release of timolol maleate.
Polyacrylic acid nanoparticles were successfully synthesized using a reverse microemulsion polymerization process. They had a narrow size range, averaging approximately 50 nm, and were stable in buffer. The particles were isolated and lyophilized in dry powder form, and were redispersible as individual particles in buffer. The drug timolol maleate was loaded into the nanoparticles from aqueous drug solutions and, when the drug-loaded particles were dispersed in a phosphate buffer solution, the drug slowly released over several hours from the nanoparticles.
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Department of Bioengineering, University of Washington, Seattle 98195, USA.
Hoffman
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AS
D000180:Acrylic Resins / Q000138:chemical synthesis* / Q000378:metabolism; D000269:Adhesives / Q000138:chemical synthesis / Q000378:metabolism; D000959:Antihypertensive Agents / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations / Q000138:chemical synthesis / Q000378:metabolism; D004339:Drug Compounding / Q000379:methods / Q000592:standards; D016503:Drug Delivery Systems / Q000379:methods* / Q000592:standards; D004355:Drug Stability; D004655:Emulsions / Q000138:chemical synthesis / Q000378:metabolism; D009092:Mucous Membrane; D009883:Ophthalmic Solutions / Q000138:chemical synthesis / Q000378:metabolism; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis / Q000378:metabolism; D013999:Timolol / Q000493:pharmacokinetics
D000180:Acrylic Resins; D000269:Adhesives; D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D004655:Emulsions; D009883:Ophthalmic Solutions; D011108:Polymers; C006903:carbopol 940; D013999:Timolol