Transaminitis in Duchenne's muscular dystrophy.
BACKGROUND
Persistently raised transaminase levels often prompt the clinician to investigate for liver pathology. Previously, some of our patients with Duchenne's muscular dystrophy have had investigations to look for liver disorders when the alanine transaminases (ALTs) were found incidentally to be high.


OBJECTIVE
The objective of the study was to ascertain the levels of the transaminases in patients with Duchenne's muscular dystrophy and to see if the levels of transaminases correlated with muscle enzymes such as creatine kinase (CK).


METHODS
This is a case series of 19 patients with Duchenne's muscular dystrophy. Alanine and aspartate transaminase (AST) levels and CK levels were measured in the serum of the patients.


RESULTS
In this series, ALT and AST levels were all found to be raised significantly in patients with biopsy-proven Duchenne's muscular dystrophy and Becker's muscular dystrophy. Alanine transaminase, in particular, was raised to a mean of 356 mmol/L, 9 times above the mean for normal. There was also good correlation between ALT and CK levels with a correlation coefficient of r = 0.80 and P value 0.01. Similar to CK, the transaminase levels were inversely proportional to mobility and to age.


CONCLUSIONS
The presence of hypertransaminasemia in patients with muscular dystrophy should be attributed to muscle breakdown rather than to liver pathology and such patients should not be over-investigated for liver disease. In the absence of liver pathology, raised transaminases may be an early sign of occult muscular dystrophy and such patients should have CK levels checked to look for evidence of muscular dystrophy.
Department of Paediatrics, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.
S K
SK
Tay
H T
HT
Ong
P S
PS
Low
D000410:Alanine Transaminase / Q000032:analysis / Q000378:metabolism*; D001219:Aspartate Aminotransferases / Q000032:analysis / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D020388:Muscular Dystrophy, Duchenne; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D012680:Sensitivity and Specificity
D015415:Biomarkers; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D003402:Creatine Kinase