Encephalitis without meningitis due to sandfly fever virus serotype toscana.
The role of Toscana (TOS) virus in producing encephalitis without meningitis is uncertain. We studied 2 cases of TOS virus encephalitis without meningitis by means of nested polymerase chain reaction assay and DNA sequencing. Findings confirm that TOS virus may directly cause encephalitis and suggest the usefulness of DNA sequencing in investigating relationships between TOS virus molecular patterns and the spectrum of neurological involvement.
Infectious Diseases Unit, Pistoia Hospital, Pistoia, Italy. mpdioni@tin.it
D
D
Dionisio
M
M
Valassina
M G
MG
Ciufolini
A
A
Vivarelli
F
F
Esperti
M G
MG
Cusi
A
A
Marchi
F
F
Mazzoli
C
C
Lupi
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D004279:DNA, Viral / Q000032:analysis; D018792:Encephalitis, Viral / Q000276:immunology / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D008297:Male; D008581:Meningitis; D008875:Middle Aged; D010217:Phlebotomus Fever / Q000276:immunology / Q000503:physiopathology / Q000821:virology*; D016856:Phlebovirus / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification; D012703:Serotyping
D000914:Antibodies, Viral; D004279:DNA, Viral