Chromatin remodeling enzymes: who's on first?
A central problem in the regulation of eukaryotic gene expression is understanding how gene-specific transcriptional activators orchestrate the recruitment of the myriad proteins that are required for transcription initiation. An emerging view indicates that activators must first target two types of chromatin remodeling enzyme to the promoter region: an ATP-dependent SWI/SNF-like complex and a histone acetyltransferase. These two enzymes appear to act synergistically to establish a local chromatin structure that is permissive for subsequent events. Furthermore, several recent studies indicate that the recruitment of chromatin remodeling enzymes must follow an obligatory, sequential order of events that is determined by either promoter context or cell-cycle position. Here we review recent developments concerning the role of chromatin remodeling enzymes in gene regulation, and propose several models to explain how different chromatin remodeling activities can be functionally coupled.
Program in Molecular Medicine, University of Massachusetts Medical School, 373 Plantation Street, Biotech 2, Suite 301, Worcester, MA 01605, USA.
C J
CJ
Fry
C L
CL
Peterson
D000123:Acetyltransferases / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D002843:Chromatin / Q000502:physiology*; D004265:DNA Helicases; D004268:DNA-Binding Proteins / Q000378:metabolism* / Q000502:physiology; D051548:Histone Acetyltransferases; D006801:Humans; D009687:Nuclear Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000378:metabolism* / Q000502:physiology
D002843:Chromatin; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C499336:SMARCA1 protein, human; C084011:SMARCA2 protein, human; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D000251:Adenosine Triphosphatases; C084108:SMARCA4 protein, human; D004265:DNA Helicases