Clear cell carcinoma of the ovary arising in a mucinous cystadenoma.
A 57 year old woman presented complaining of increasing abdominal swelling of six months duration. A mixed solid cystic left ovarian tumour measuring 24 cm in diameter was excised. Histology showed numerous cysts lined by benign mucinous epithelium blending imperceptibly into borderline clear cell and mucinous areas that in turn merged with an invasive clear cell carcinoma. To the best of our knowledge, this is the first reported case of clear cell carcinoma arising in a mucinous cystadenoma. The implications for the previously postulated pathogenesis of these tumours are discussed.
Department of Morbid Anatomy and Histopathology, St Bartholomew's Hospital, West Smithfield, London EC1A 7BE, UK.
N
N
Dutt
D M
DM
Berney
D018262:Adenocarcinoma, Clear Cell / Q000473:pathology*; D018291:Cystadenoma, Mucinous / Q000473:pathology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*