Allele frequency of HLA-B39 in the Japanese population and identification of a novel B39 allele, B*3923.
A new HLA-B39 allele, B*3923, was found in the Japanese population. Compared with B*39022, the new allele had a single point mutation at position 503 in exon 3 with an amino acid substitution, Gln144Arg. To determine B39 allele frequency in Japanese, 275 B39-positive samples from 3277 Japanese individuals were examined by polymerase chain reaction using microtitre plate hydribization (PCR-MPH) and single-strand conformation polymorphism (PCR-SSCP). The frequency of B*3923 was estimated to be 0.4% in B39 alleles of the Japanese population. B*3923 was found in samples from four Japanese individuals, all of whom have DRB1*1406.
Japanese Red Cross Central Blood Center, Tokyo, Japan.
T
T
Akesaka
K
K
Kashiwase
Y
Y
Ishikawa
H
H
Tanaka
M
M
Shimizu
S
S
Kawai
T
T
Akaza
T
T
Takahashi
T
T
Juji
D044466:Asian People / Q000235:genetics; D005787:Gene Frequency; D015235:HLA-B Antigens / Q000235:genetics*; D059946:HLA-B39 Antigen; D006239:Haplotypes; D006801:Humans; D007564:Japan; D008969:Molecular Sequence Data; D015345:Oligonucleotide Probes; D017354:Point Mutation; D018807:Polymorphism, Single-Stranded Conformational
D015235:HLA-B Antigens; D059946:HLA-B39 Antigen; D015345:Oligonucleotide Probes