The effects of delta sleep-inducing peptide on the intensity of lipid peroxidation and xanthine oxidase activity in rat tissues during cold stress.
Exogenous delta sleep-inducing peptide given i.p. to intact rats at a dose of 12 microg/100 g decreased the levels of diene conjugates and Schiff bases in liver and brain tissues and had no effect on xanthine oxidase activity in these tissues. Cold stress was accompanied by increases in xanthine oxidase activity in rat liver and brain, with a consequent accumulation of diene conjugates and Schiff bases, as compared with intact animals. Preliminary administration of delta sleep-inducing peptide before three days of cold stress led to decreases in xanthine oxidase activity and lipid peroxidation products in the liver and brain, as compared with values in stressed rats. The protective effect of delta sleep-inducing peptide in stress is discussed.
Bondarenko
T I
TI
Department of Biochemistry and Immunobiology, Rostov State University, Rostov on Don, Russia.
Milyutina
N P
NP
Shustanova
T A
TA
Mikhaleva
I I
II
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D003080:Cold Temperature / Q000009:adverse effects*; D003701:Delta Sleep-Inducing Peptide / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009243:NAD / Q000378:metabolism; D051381:Rats; D012545:Schiff Bases; D013312:Stress, Physiological / Q000378:metabolism / Q000503:physiopathology*; D014527:Uric Acid / Q000378:metabolism; D014969:Xanthine Oxidase / Q000378:metabolism*
D012545:Schiff Bases; D009243:NAD; D014527:Uric Acid; D003701:Delta Sleep-Inducing Peptide; D014969:Xanthine Oxidase