New cytotoxic isomalabaricane triterpenes from the sponge Jaspis species.
Three new isomalabaricane triterpenes, 29-hydroxystelliferin E (1), 29-hydroxystelliferin A (2), and stelliferin G (3), together with the known triterpene 3-epi-29-hydroxystelliferin E (4), were isolated from the organic extract of the sponge Jaspis sp. collected in the South Pacific. All the compounds isolated showed antiproliferative activity against melanoma cells (MALME-3M).
Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, National Cancer Institute, NCI-FCRDC, Frederick, MD 21702, USA.
K M
KM
Meragelman
T C
TC
McKee
M R
MR
Boyd
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C429607:29-hydroxystelliferin A; C429605:29-hydroxystelliferin E; C406628:3-epi-29-hydroxystelliferin E; D000970:Antineoplastic Agents; D014315:Triterpenes; C429606:stelliferin G