Action of histamine on eustachian tube function.
BACKGROUND
The role of allergy in eustachian tube dysfunction is controversial. In this study, allergy was simulated by exposure to histamine, and eustachian tube function testing was performed in an experimental rat model.


METHODS
Ventilatory function was assessed by measuring passive opening and closing pressures of the eustachian tube after challenge with either transtympanic or intranasal histamine. The mucociliary clearance time of the tubotympanum was assessed by observing dye transport from the middle ear to the nasopharynx after challenge with either transtympanic histamine or control solution.


RESULTS
There was a statistically significant increase in passive opening and closing pressures with transtympanic histamine versus intranasal histamine. In addition, mucociliary clearance times of the tubotympanum after transtympanic histamine showed a statistically significant increase when compared with those after transtympanic control solution.


CONCLUSIONS
Transtympanic histamine exposure causes eustachian tube dysfunction in the rat by increasing passive opening and closing pressures of the eustachian tube and impairing mucociliary clearance time.
University of North Carolina at Chapel Hill, USA.
B W
BW
Downs
H F
HF
Butehorn
J
J
Prazma
A S
AS
Rose
J C
JC
Stamat
H C
HC
Pillsbury
D000281:Administration, Intranasal; D000287:Administration, Topical; D000818:Animals; D005064:Eustachian Tube / Q000187:drug effects* / Q000503:physiopathology; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D007759:Labyrinth Diseases / Q000503:physiopathology; D009079:Mucociliary Clearance / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014432:Tympanic Membrane / Q000187:drug effects
D006632:Histamine