Acute renal ischemia model in dogs: effects of metoprolol.
BACKGROUND
To study the functional and histological alterations in dog kidneys submitted to total ischemia for thirty minutes and the possible metoprolol protective action.


METHODS
Sixteen dogs anesthetized with sodium pentobarbital (SP) were studied and divided into two groups: G1-8 dogs submitted to left nephrectomy and right renal artery clamping for thirty minutes, and G2-8 dogs submitted to the same procedures of G1 and to the administration of 0.5 mg x kg(-1) metoprolol before ischemia. Attributes of renal function were studied.


RESULTS
There was acute tubular necrosis and a decrease of renal blood flow and glomerular filtration, and a increase of renal vascular resistance in both groups.


CONCLUSIONS
The thirty minute renal ischemia appears to have determined the alterations found in the renal function and histology in both groups. Metoprolol, used in G2, as to the time and dose applied didn't protect the kidney from the ischemic episode.
Módolo
N S
NS
Department of Anesthesiology, Faculty of Medicine, UNESP, Botucatu, São Paulo, Brazil. nmodolo@fmb.unesp.br
Castiglia
Y M
YM
Ganem
E M
EM
Braz
J R
JR
Vianna
P T
PT
Vane
L A
LA
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D007668:Kidney / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D007683:Kidney Tubular Necrosis, Acute / Q000188:drug therapy*; D008790:Metoprolol / Q000494:pharmacology*; D012079:Renal Circulation; D012083:Renin / Q000378:metabolism; D015427:Reperfusion Injury / Q000517:prevention & control*; D013997:Time Factors
D000319:Adrenergic beta-Antagonists; D012083:Renin; D008790:Metoprolol