Technetium-99m methoxy-isobutyl-isonitrile chest single photon emission computed tomography to detect mediastinal lymph node metastasis in patients with non-small cell lung cancer: comparison with computed tomography.
This study evaluated the clinical role of Tc-99m-methoxyisobtylisonitrile (Tc-MIBI) single photon emission computed tomography (SPECT) of the chest in the detection of mediastinal lymph node (MLN) metastasis in patients with non-small cell lung cancer (NSCLC). Twenty-five patients with proven NSCLC were enrolled in this study. Each of the patients received computed tomography (CT) of the chest and Tc-MIBI SPECT of the chest for presurgical staging. A postsurgical pathologic diagnosis was made and these patients were evaluated for the study of mediastinal lymph nde (MLN) involvement. Meanwhile, 10 volunteers also accepted Tc-MIBI SPECT of the chest for comparison. The results showed that the diagnostic sensitivity, specificity and accuracy of Tc-MIBI chest SPECT were 81.8%, 85.7% and 84% and for chest CT they are 36.3%, 85.7% and 64%, respectively. Our results indicated that Tc-MIBI chest SPECT was more sensitive and accurate than chest CT in the evaluation and detection of MLN involvement in the NSCLC patients.
Shiau
Y C
YC
Department of Nuclear Medicine, Far East Memorial Hospital, Taipei.
Hsieh
J F
JF
Tsai
S C
SC
Ho
Y J
YJ
Sun
S S
SS
Kao
C H
CH
D000230:Adenocarcinoma / Q000000981:diagnostic imaging; D000368:Aged; D018287:Carcinoma, Large Cell / Q000000981:diagnostic imaging; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging*; D008297:Male; D008482:Mediastinum; D008875:Middle Aged; D009367:Neoplasm Staging; D013902:Radiography, Thoracic; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed
D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi