Hypertrophic osteoarthropathy: an unusual manifestation in nasopharyngeal cancer.
A patient with nasopharyngeal carcinoma developed clubbing and hypertrophic osteoarthropathy 6 months before radiological detection of secondary deposits in the lung. Another patient with nasopharyngeal carcinoma developed digital clubbing and hypertrophic osteoarthropathy 6 months after the discovery of lung metastases. Development of a paraneoplastic syndrome in the form of hypertrophic osteoarthropathy and digital clubbing is very rare. This manifestation of nasopharyngeal cancers is presented, with a short review of its biology and pathogenesis.
Department of Radiotherapy and Oncology, School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia. biswa@kb.usm.my
B M
BM
Biswal
A
A
Kareem
N M
NM
Ahmed
D000328:Adult; D003131:Combined Modality Therapy; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D010005:Osteoarthropathy, Secondary Hypertrophic / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology*