Preparation and dissolution property of ipriflavone solid dispersion.
OBJECTIVE
To prepare and identify ipriflavone (IP) solid dispersion, and determine its dissolution property.


METHODS
The solvent method was used for preparation and differential scanning calorimetry (DSC), X-ray diffraction and infrared spectrophotometry for identification of IP solid dispersion. The dissolution of the dispersion was determined with paddle method.


RESULTS
The dissolution of IP solid dispersion consisting of IP and povidone-k30 (PVP) (1:8) in artificial gastric juice is 6.15 times as high as that of IP alone. The DSC curves, X-ray diffraction patterns and infrared spectrophotometries of IP have been changed obviously by the dispersion.


CONCLUSIONS
The dissolution of IP is increased by solid dispersion method.
Li
Y P
YP
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 200031, China. ypli@server.shcnc.ac.cn
Zhang
X Y
XY
Zhou
J J
JJ
Pei
Y Y
YY
D007529:Isoflavones / Q000737:chemistry*; D012995:Solubility; D013678:Technology, Pharmaceutical
D007529:Isoflavones; C018986:ipriflavone