A new and simple approach to chemical complexity. Application to the synthesis of natural products.
A new approach to describe the complexity of chemical structures is proposed. This index is simple and can be easily programmed. It derives from Whitlock's index and, despite its empirical character, provides results paralleling those obtained with the mathematical Bertz index. It has been applied to follow the strategic progress of some natural product syntheses.
Laboratoire AM3, Case 561, Faculte des Sciences de St. Jérôme, 13397 Marseille Cedex 20, France. rene.barone@am3.u-3mrs.fr
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