Computational models of blood flow in the circle of Willis.
A two-dimensional, steady state model of the circle of Willis has been developed. To simulate the peripheral resistance of the cerebrovascular tree, blocks of porous media were used. Their effective resistance was kept constant, disregarding the effects of arterial auto-regulation. The model was then used to simulate different common abnormalities of the circle of Willis while a range of varying boundary conditions was imposed to the right internal carotid artery (ICA). The total flux was tabulated and compared favourably with both clinical measurements and other models of the circle of Willis. Relevant fluid dynamics effects were also observed and analysed. The present model demonstrates that the use of CFD can produce physiological results if the appropriate boundary conditions are used. We can provide clinicians with a priority list of the severity of the flux reduction for the considered abnormalities for different degrees of stenosis of the right ICA. From this study it is apparent that the redistribution of blood via the circle of Willis is mainly driven by changes in the vascular resistance of the brain rather than in the local arterial geometry. The use of valid peripheral resistances allows for a more realistic model of the circle of Willis but also highlights the need for more accurate means to estimate the vascular resistance of a patient.
School of Mechanical Engineering, The University of Leeds, Leeds, UK.
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Ferrández
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David
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Bamford
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Scott
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Guthrie
D000818:Animals; D001783:Blood Flow Velocity; D001921:Brain / Q000098:blood supply* / Q000502:physiology; D002343:Carotid Artery, Internal / Q000502:physiology; D002536:Cerebral Arteries / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002941:Circle of Willis / Q000502:physiology*; D019295:Computational Biology / Q000379:methods; D007839:Functional Laterality; D006801:Humans; D008955:Models, Cardiovascular; D014655:Vascular Resistance