Solution structure of (+)-discodermolide.
[structure: see text]. The solution structure of (+)-discodermolide (1) has been determined via 1- and 2-D NMR techniques in conjunction with Monte Carlo conformational analysis. Taken together, the results demonstrate that in solution (+)-discodermolide occupies a helical conformation remarkably similar to the solid state conformation.
Smith
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AB
Department of Chemistry, Monell Chemical Senses Center, and Laboratory for Research on the Structure of Matter, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. smithab@sas.upenn.edu
LaMarche
M J
MJ
Falcone-Hindley
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M
D000473:Alkanes; D000818:Animals; D002219:Carbamates; D007166:Immunosuppressive Agents / Q000737:chemistry*; D007783:Lactones / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008958:Models, Molecular; D009010:Monte Carlo Method; D011161:Porifera / Q000737:chemistry*; D011753:Pyrones; D012996:Solutions; D014404:Tubulin / Q000737:chemistry
D000473:Alkanes; D002219:Carbamates; D007166:Immunosuppressive Agents; D007783:Lactones; D011753:Pyrones; D012996:Solutions; D014404:Tubulin; C071229:discodermolide