Avascular necrosis of bone in patients with human immunodeficiency virus infection: report of 6 cases and review of the literature.
In 1998 and 1999, we diagnosed avascular necrosis of bone in 6 patients in our human immunodeficiency virus clinic practice, an incidence of 0.45%, which is 45 times greater than would be expected in the general population. Antiphospholipid antibodies and hyperlipidemia secondary to protease inhibitor therapy have been implicated as possible etiologies; however, these abnormalities cannot explain all cases of avascular necrosis of bone reported in patients with human immunodeficiency virus infection.
Division of Infectious Disease, Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI,USA. pbrown@intmed.wayne.edu
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P
Brown
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Crane
D000328:Adult; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D008824:Michigan / Q000453:epidemiology; D008875:Middle Aged; D010020:Osteonecrosis / Q000188:drug therapy / Q000453:epidemiology* / Q000276:immunology / Q000503:physiopathology
D017152:Antibodies, Antiphospholipid