Effect of gelling conditions and mechanical treatment on drug availability from a lipogel.
This study has been conducted to determine whether the rheological differences depending on gelling and treatment conditions could have an influence on drug availability. Lipogels with constant composition were obtained by gelling olive oil with monodiglycerides at rest, under stirring, and milled after gelling. The considerable differences in rheological characteristics produced significant differences on in vitro drug release tests, whereas a lesser influence was observed on in vitro simulated absorption test. The rheological differences appeared not to influence in vivo drug availability. Also, rheological differences owing to the concentration of the gelling agent showed no significant influence on in vivo availability.
Department of Pharmaceutical Sciences, Faculty of Pharmacy, University of Padua, Padova, Italy. realdon@dsfarm.unipd.it
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Realdon
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Ragazzi
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Ragazzi
D000042:Absorption; D019540:Area Under Curve; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004075:Diglycerides; D004339:Drug Compounding; D005782:Gels; D008055:Lipids / Q000737:chemistry*; D009823:Ointment Bases / Q000737:chemistry*; D009824:Ointments; D000069463:Olive Oil; D010938:Plant Oils; D012212:Rheology; D012995:Solubility; D014783:Viscosity
D004075:Diglycerides; D005782:Gels; D008055:Lipids; D009823:Ointment Bases; D009824:Ointments; D000069463:Olive Oil; D010938:Plant Oils