Possible strategies to protect the preterm brain against the fetal inflammatory response.
The accruing evidence that a fetal inflammatory response is the link between antenatal infection and white matter damage in the preterm newborn infant offers room for speculation how this harmful sequence could be interrupted. Enhancement of endogenous protection, response modification, and damage limitation downstream could be helpful strategies for intervention design. Appropriate observational and experimental studies are needed before clinical interventions can be initiated.
Dammann
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Neuroepidemiology Unit, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Leviton
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A
D000906:Antibodies / Q000276:immunology; D001812:Blood-Brain Barrier / Q000502:physiology; D001921:Brain / Q000196:embryology* / Q000276:immunology / Q000378:metabolism; D016207:Cytokines / Q000276:immunology; D005315:Fetal Diseases / Q000276:immunology / Q000517:prevention & control*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000276:immunology / Q000517:prevention & control*; D007236:Infant, Small for Gestational Age; D019102:Infant, Very Low Birth Weight; D007249:Inflammation / Q000196:embryology* / Q000276:immunology / Q000517:prevention & control*; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism; D018121:Receptors, Cytokine / Q000037:antagonists & inhibitors
D000906:Antibodies; D016207:Cytokines; D018121:Receptors, Cytokine; D018799:Intercellular Adhesion Molecule-1; D020780:Matrix Metalloproteinase 9