Nadine Dobrovolskaïa-Zavadskaïa and the dawn of developmental genetics.
In one of the first genetic screens aimed at identifying induced developmental mutants, Nadine Dobrovolskaïa-Zavadskaïa, working at the Pasteur Laboratory in the 1920s, isolated and characterized a mutation affecting Brachyury, a gene that regulates tail and axial development in the mouse. Dobrovolskaïa-Zavadskaïa's analysis of Brachyury and other mutations affecting tail development were among the earliest attempts to link gene action with a tissue-specific developmental process in a vertebrate. Her analyses of genes that interacted with Brachyury led to the discovery of the t-haplotype chromosome of mouse. After 70 years, Brachyury and the multiple genes with which it interacts continue to occupy a prominent focus in developmental biology research. A goal of this review is to identify the contributions that Dobrovolskaïa-Zavadskaïa made to our current thinking about Brachyury and how she helped to shape the dawn of the field of developmental genetics. BioEssays 23:365-371, 2001.
The Institute of Molecular Agrobiology, National University of Singapore, Singapore. vlad@ima.org.sg
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D000818:Animals; D005326:Fetal Proteins; D018507:Gene Expression Regulation, Developmental; D049672:History, 19th Century; D049673:History, 20th Century; D051379:Mice; D016296:Mutagenesis; D009369:Neoplasms / Q000235:genetics; D020825:T-Box Domain Proteins / Q000378:metabolism*; D000098908:Brachyury Protein
D005326:Fetal Proteins; D020825:T-Box Domain Proteins; D000098908:Brachyury Protein