Platelet activation markers and soluble adhesion molecules in patients with systemic lupus erythematosus.
We assessed the role of platelet activation markers (PMPs, Annexin V and CD62P on activated platelets), cytokines (IL-1 beta, IL-4, IL-6, IFN- gamma, GM-CSF, and TNF alpha ), and soluble factors (sIL-2R, TM, sHLA-1, beta(2) -m, sVCAM-1, sPECAM-1, sP-selectin and sE-selectin) in vascular damage related to SLE. There were differences in the levels of PMPs and platelet activation markers between the SLE patients and controls (PMPs: 493+/-82 vs. 328+/-36, p<0.05; plt-CD62P; 8.5%+/-1.2 % vs. 4.6%+/-0.7 %, p<0.05; plt-Annexin V: 11.3%+/-2.1 % vs. 4.9%+/-0.6 %, p<0.01). There were no differences in the levels of IFN- gamma between the groups. However, the levels of IL-1 beta, IL-4, IL-6, GM-CSF, TNF alpha, and soluble factors were higher in the SLE patients than in the controls. The levels of IL-4, IL-6, beta2 -m, sIL-2R, sVCAM-1, sP-selectin, and sE-selectin in SLE patients with elevated sTM levels were higher than those in the SLE patients without elevated sTM levels. On the other hand, elevations of sIL-2R, sVCAM-1, and sP-selectin were not found in patients with Behçet disease or rheumatoid arthritis. The levels of platelet CD62P, platelet annexin V, and PMP were significantly elevated in high-sTM patients. These findings suggest the possibility that activated platelets and cytokines participate in the pathogenesis of SLE in patients with elevated sTM levels.
The First Department of Internal Medicine, Kansai Medical University, Osaka, Japan.
M
M
Nagahama
S
S
Nomura
Y
Y
Ozaki
C
C
Yoshimura
H
H
Kagawa
S
S
Fukuhara
D000328:Adult; D017304:Annexin A5 / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000737:chemistry* / Q000276:immunology*; D015815:Cell Adhesion Molecules / Q000097:blood* / Q000502:physiology; D016207:Cytokines / Q000097:blood; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000209:etiology / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D010316:Particle Size; D015539:Platelet Activation / Q000276:immunology*; D012995:Solubility; D018180:Thrombomodulin / Q000097:blood
D017304:Annexin A5; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D016207:Cytokines; D019007:P-Selectin; D018180:Thrombomodulin