A review of mechanisms controlling ovulation with implications for the anovulatory effects of polychlorinated dibenzo-p-dioxins in rodents.
Polychlorinated dibenzo-p-dioxins (PCDDs) can impinge on female fertility by preventing ovulation. In this review, the aspects of normal ovulatory physiology most relevant to our current understanding of PCDD action on the ovary are briefly reviewed. This is followed by a comprehensive assessment of data relevant to the effects of PCDDs during ovulation in the rat. PCDDs interrupt ovulation through direct effects on the ovary in combination with dysfunction of the hypothalamo-hypophyseal axis.
Center for Reproductive Sciences, University of Kansas Medical Center, 3901 Rainbow Boulevard, Kansas City, KS 66160-7417, USA.
B K
BK
Petroff
K F
KF
Roby
X
X
Gao
D
D
Son
S
S
Williams
D
D
Johnson
K K
KK
Rozman
P F
PF
Terranova
D000818:Animals; D000858:Anovulation / Q000139:chemically induced*; D004785:Environmental Pollutants / Q000633:toxicity*; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects / Q000502:physiology*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000633:toxicity*; D051381:Rats
D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins