Adsorption of erythropoietin and growth hormone to peritoneal dialysis bags and tubing.
OBJECTIVE
To study the adsorption of erythropoietin and growth hormone to dialysis bags and tubing.


METHODS
In vitro study in which radiolabeled erythropoietin and recombinant human growth hormone were added to small-volume (50- and 250-mL) dialysis bags. Recovery was measured after 15-minute dwells. Experiments were performed in triplicate.


METHODS
University hospital.


RESULTS
Adsorption of erythropoietin and growth hormone was less than 7%.


CONCLUSIONS
Adsorption of erythropoietin and recombinant human growth hormone to dialysis bags and tubing is minimal. This finding provides another argument in favor of intraperitoneal therapy in pediatric peritoneal dialysis.
Department of Pediatrics, Wilhelmina Children's University Hospital, Utrecht, The Netherlands. c.h.schroder@wkz.azu.nl
C H
CH
Schröder
L M
LM
Swinkels
R E
RE
Reddingius
F G
FG
Sweep
H L
HL
Willems
L A
LA
Monnens
D000327:Adsorption; D002648:Child; D004921:Erythropoietin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013006:Growth Hormone / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007457:Iodine Radioisotopes; D010530:Peritoneal Dialysis / Q000295:instrumentation*; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000295:instrumentation*
D007457:Iodine Radioisotopes; D004921:Erythropoietin; D013006:Growth Hormone