Role of thrombotic vascular risk factors in inflammatory bowel disease.
Thromboembolic disease is a significant cause of morbidity and mortality in patients with inflammatory bowel disease (IBD). It is recognized that a hypercoagulable state exists in IBD which involves all components of the clotting system. It has been suggested that this hypercoagulable state is closely linked to the disease pathogenesis. Recent studies have shown that genetic defects such as factor V Leiden mutation and C677T methylenetetrahydrofolate reductase polymorphism associated with hyperhomocysteinemia seem to interfere in the thrombotic manifestations of IBD. Acquired factors such as antiphospholipid antibodies could also participate in the development of the thrombotic process. Deficiencies of other anticoagulant factors play a less important role in the thrombosis, and therefore it is not surprising that the results on these factors in IBD are contradictory. In conclusion the resultant gene-gene and gene-environment interactions between risk factors are the key to the understanding of why an IBD patient develops thrombosis at a specific point in time.
Department of Gastroenterology, University Hospital Heraklion, Greece. ktjohn@her.forthnet.gr
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Koutroubakis
D017152:Antibodies, Antiphospholipid / Q000032:analysis; D001777:Blood Coagulation / Q000502:physiology*; D005165:Factor V / Q000032:analysis; D006710:Homocysteine / Q000097:blood; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000097:blood / Q000276:immunology / Q000503:physiopathology*; D012307:Risk Factors; D013927:Thrombosis / Q000150:complications / Q000503:physiopathology
D017152:Antibodies, Antiphospholipid; C095381:factor V Leiden; D006710:Homocysteine; D005165:Factor V