Analysis of metronidazole, clarithromycin and tetracycline resistance of Helicobacter pylori isolates from Korea.
Antibiotic resistance in Helicobacter pylori varies according to geographical region. We studied the primary resistance rates among 652 H. pylori isolated from Korea in relation to collection date, disease presentation, age and gender. Resistance rates were 40.6% (metronidazole), 5.9% (clarithromycin), 5.3% (tetracycline), 0% (amoxycillin), 1.5% (furazolidone) and 1.5% (nitrofurantoin). Resistance to metronidazole and clarithromycin increased from 1994 to 1999 (from 33.3 to 47.7% and 4.8 to 7.7%, respectively), but the differences only reached significance when rates of metronidazole resistance in women were compared with those in men (48.6 versus 36.9%).
Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
J J
JJ
Kim
R
R
Reddy
M
M
Lee
J G
JG
Kim
F A
FA
El-Zaatari
M S
MS
Osato
D Y
DY
Graham
D H
DH
Kwon
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D017291:Clarithromycin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology / Q000382:microbiology* / Q000503:physiopathology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007723:Korea / Q000453:epidemiology; D008297:Male; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015995:Prevalence; D012727:Sex Characteristics; D013752:Tetracycline / Q000494:pharmacology*; D013753:Tetracycline Resistance
D008795:Metronidazole; D013752:Tetracycline; D017291:Clarithromycin