[Subacute neuropathy, multiple cancers, and Gougerot-Sjögren syndrome: contribution of anti-Hu antibody].
We report the case of a patient presenting a subacute, predominantly sensory neuropathy. The work up revealed a Sjögren's syndrome and a breast carcinoma. The presence of anti-Hu antibodies, identified by Western Blot using purified recombinant HuD protein, and the absence of the Hu antigen in the breast carcinoma ruled out the responsibility of the Sjögren's syndrome or breast carcinoma. In this context, the most likely diagnosis was a subacute neuropathy associated with small cell lung cancer, which was indeed discovered 3 years later.
Fédération de Neurologie Mazarin, INSERM U.495, Paris.
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Auf
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Benyahia
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Orcel
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Beigelman
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Delattre
D000368:Aged; D001323:Autoantibodies / Q000032:analysis*; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology; D018288:Carcinoma, Small Cell / Q000473:pathology; D051959:ELAV Proteins; D000067779:ELAV-Like Protein 4; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000276:immunology*; D009422:Nervous System Diseases / Q000150:complications / Q000175:diagnosis* / Q000276:immunology; D016601:RNA-Binding Proteins / Q000032:analysis / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000150:complications / Q000175:diagnosis* / Q000276:immunology
D001323:Autoantibodies; D051959:ELAV Proteins; D000067779:ELAV-Like Protein 4; C498010:ELAVL4 protein, human; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins