Dendrimers and hyperbranched polymers as high-loading supports for organic synthesis.
Polymeric supports have become a big necessity for automated synthesis and combinatorial chemistry, yet, the loading capacities of most polystyrene resins are very limited (typically < 1.5 mmol x g(-1)). Dendrimers and hyperbranched polymers have been discussed for this application and now became readily available. These soluble polymers can either be used directly as high-loading supports for substrates, reagents, and catalysts or alternatively in hybrid polymers linked to conventional polystyrene resins.
Haag
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Freiburger Materialforschungszentrum und Institut für Makromolekulare Chemie, Albert-Ludwigs-Universität Freiburg, Germany. haag@fmf.uni-freiburg.de