Non-convulsive status epilepticus in two patients receiving tiagabine add-on treatment.
We report two patients with epileptic syndromes who developed non-convulsive status epilepticus under adjunctive antiepileptic therapy with tiagabine. The paradoxical effect may be the result of a difference in effects between GABAA and GABAB receptors, or between GABA receptors in different regions of the brain.
Skodda
S
S
Department of Neurology, Ruhr-Universität Bochum, Knappschaftskrankenhaus, In der Schornau 23-25, 44892 Bochum, Germany.
Kramer
I
I
Spittler
J F
JF
Gehlen
W
W
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D001921:Brain / Q000503:physiopathology; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009557:Nipecotic Acids / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use*; D018079:Receptors, GABA / Q000502:physiology; D013226:Status Epilepticus / Q000139:chemically induced* / Q000503:physiopathology*; D000078308:Tiagabine
D000927:Anticonvulsants; D009557:Nipecotic Acids; D018079:Receptors, GABA; D000078308:Tiagabine