The mechanical behavior of vascular grafts: a review.
The development of intimal hyperplasia (IH) near the anastomosis of a vascular graft to artery is directly related to changes in the wall shear rate distribution. Mismatch in compliance and diameter at the end-to-end anastomosis of a compliant artery and rigid graft cause shear rate disturbances that may induce intimal hyperplasia and ultimately graft failure. The principal strategy being developed to prevent IH is based on the design and fabrication of compliant synthetic or innovative tissue-engineered grafts with viscoelastic properties that mirror those of the human artery. The goal of this review is to discuss how mechanical properties including compliance mismatch, diameter mismatch, Young's modulus and impedance phase angle affect graft failure due to intimal hyperplasia.
University Department of Surgery, Royal Free and University College Medical School, University College London and The Royal Free Hospital, UK. a.seifalian@rfc.ucl.ac.uk
H J
HJ
Salacinski
S
S
Goldner
A
A
Giudiceandrea
G
G
Hamilton
A M
AM
Seifalian
A
A
Edwards
R J
RJ
Carson
D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001807:Blood Vessel Prosthesis; D003187:Compliance
D001672:Biocompatible Materials