A case report: persistent acantholytic dermatosis in chronic renal failure.
BACKGROUND
This is the second case of persistent acantholytic dermatosis in a patient with chronic renal failure, seen at the same institution in 2 years.


METHODS
A 70-year-old Chinese man with end-stage renal failure on continuous ambulatory peritoneal dialysis for 6 months presented with pruritic rashes over the scalp and chest for 3 months. Histologically, the lesions resembled Darier's disease. Differential diagnoses include Darier's disease, Grover's disease and perforating dermatosis in chronic renal failure.


METHODS
The patient was treated with anti-histamines, topical steroids and emollients.


RESULTS
Resolution of pruritus was documented. However, the extensive hyperkeratotic papules remained persistent.


CONCLUSIONS
A chronic non-remitting course is to be expected for this dermatoses in which the aetiology is unknown.
Wong
W M
WM
National Skin Centre, 1 Mandalay Road, Singapore 308205.
Chua
S H
SH
D000051:Acantholysis / Q000150:complications* / Q000473:pathology* / Q000628:therapy; D000368:Aged; D001707:Biopsy, Needle; D002908:Chronic Disease; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000150:complications* / Q000473:pathology / Q000628:therapy