Bone allografts and adjuvant cisplatin for the treatment of canine appendicular osteosarcoma in 18 dogs.
The results achieved in 18 dogs following the use of frozen bone cortical allografts for limb-sparing resection of non-metastatic canine appendicular osteosarcoma are presented. Three to five cisplatin doses (70 mg/m2) were administered, starting the day after surgery. The mean and median survival times were 478 and 266 days (range 80 to 2,611 days), respectively. The survival rate was 94 per cent at three months, 78 per cent at six months, 35 per cent at 12 months, 23 per cent at 18 months and 19 per cent at 24 months; the disease-free interval was 80 to 1,246 days (mean 365 days, median 266 days). Lung metastasis developed in 55 per cent of the dogs within one year. Complications were observed in 14/18 dogs (78 per cent), comprising local recurrence (28 per cent), allograft infection (39 per cent) and implant failure (11 per cent). Despite complications, limb sparing is a useful alternative to amputation in selected cases of appendicular osteosarcoma.
Morello
E
E
Department of Patologia Animale, Torino Turin, Italy.
Buracco
P
P
Martano
M
M
Peirone
B
B
Capurro
C
C
Valazza
A
A
Cotto
D
D
Ferracini
R
R
Sora
M
M
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000662:veterinary*; D016025:Bone Transplantation / Q000662:veterinary*; D017024:Chemotherapy, Adjuvant / Q000662:veterinary; D002945:Cisplatin / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy / Q000601:surgery*; D004285:Dogs; D005121:Extremities / Q000601:surgery; D006084:Graft Rejection / Q000662:veterinary; D008175:Lung Neoplasms / Q000556:secondary / Q000662:veterinary; D009364:Neoplasm Recurrence, Local / Q000662:veterinary; D012516:Osteosarcoma / Q000188:drug therapy / Q000556:secondary / Q000601:surgery / Q000662:veterinary*; D015996:Survival Rate; D013997:Time Factors; D014184:Transplantation, Homologous / Q000662:veterinary
D000970:Antineoplastic Agents; D002945:Cisplatin