Sesamolin from sesame seed inhibits proliferation by inducing apoptosis in human lymphoid leukemia Molt 4B cells.
The exposure of human lymphoid leukemia Molt 4B cells to sesamolin, a component of sesame seed led to both growth inhibition and the induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with sesamolin. The fragmentation of DNA by sesamolin to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition of Molt 4B cells by sesamolin results from the induction of apoptosis in the cells.
Kuki Sangyo Co., Ltd., 11 Onoue-cho, Yokkaichi-city, Mie 510-0059, Japan.
Y
Y
Miyahara
H
H
Hibasami
H
H
Katsuzaki
K
K
Imai
T
T
Komiya
D000970:Antineoplastic Agents / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D004149:Dioxoles / Q000494:pharmacology*; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000473:pathology*; D012639:Seeds / Q000737:chemistry*; D012715:Sesame Oil / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004149:Dioxoles; D006131:Growth Inhibitors; C054124:sesamolin; D012715:Sesame Oil