Combinatorial biosynthesis of polyketides and nonribosomal peptides.
The engineering of polyketide biosynthesis has begun to provide robust targeted libraries for screening against pharmaceutically relevant targets. New technologies that offer methodology for the rapid generation of more structurally diverse libraries have now been demonstrated.
University Chemical Laboratory and Cambridge Centre for Molecular Recognition, Cambridge, UK. js24@cam.ac.uk
J
J
Staunton
B
B
Wilkinson
D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001685:Biological Factors / Q000096:biosynthesis; D020650:Combinatorial Chemistry Techniques; D004353:Drug Evaluation, Preclinical / Q000379:methods; D008861:Microsomes; D009097:Multienzyme Complexes / Q000096:biosynthesis* / Q000235:genetics; D010453:Peptide Synthases / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D011108:Polymers; D015202:Protein Engineering / Q000379:methods*
D000900:Anti-Bacterial Agents; D001685:Biological Factors; D009097:Multienzyme Complexes; D010455:Peptides; D011108:Polymers; D010453:Peptide Synthases