A case of pulmonary toxicity associated with G-CSF and doxorubicin administration.
The cytokine growth factor, G-CSF (granulocyte colony-stimulating factor), is commonly used in oncologic practice and is generally believed to be a safe agent to administer. We describe here a case of pulmonary toxicity associated with the concurrent administration of G-CSF and doxorubicin. We contend that G-CSF contributed to the life-threatening lung injury in our patient, and discuss additional reports in the literature of pulmonary toxicity associated with the use of this agent.
Department of Medicine, University of Chicago Medical Center, Chicago, Ill., USA.
C F
CF
Eisenbeis
D
D
Winn
S
S
Poelman
C V
CV
Polsky
J H
JH
Rubenstein
O I
OI
Olopade
D001706:Biopsy; D001980:Bronchi / Q000473:pathology; D004317:Doxorubicin / Q000008:administration & dosage* / Q000633:toxicity*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000633:toxicity*; D006801:Humans; D008875:Middle Aged; D011014:Pneumonia / Q000139:chemically induced*
D016179:Granulocyte Colony-Stimulating Factor; D004317:Doxorubicin