Isolation, and biological properties of a new cell cycle inhibitor, curvularol, isolated from Curvularia sp. RK97-F166.
A new cell growth inhibitor, curvularol, was isolated from the fermentation broth of Curvularia sp. RK97-F166. Curvularol showed no antibacterial activity, and very weak antifungal activity. However, curvularol inhibited the cell cycle progression of normal rat kidney (NRK) cells in G1 phase at 150 ng/ml. Curvularol induced the morphological reversion of srcts-transformed NRK cells at 100 ng/ml, and inhibited protein synthesis same as cycloheximide.
RIKEN Institute, Saitama, Japan.
Y
Y
Honda
M
M
Ueki
G
G
Okada
R
R
Onose
R
R
Usami
K
K
Horikoshi
H
H
Osada
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D005285:Fermentation; D006801:Humans; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000145:classification / Q000378:metabolism*; D015394:Molecular Structure; D011500:Protein Synthesis Inhibitors / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D012313:RNA / Q000096:biosynthesis / Q000187:drug effects; D051381:Rats; D014255:Trichothecenes / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D019061:src-Family Kinases / Q000187:drug effects / Q000235:genetics / Q000378:metabolism
D011500:Protein Synthesis Inhibitors; D014255:Trichothecenes; C423645:curvularol; D012313:RNA; D004247:DNA; D019061:src-Family Kinases