Sortilin/neurotensin receptor-3: a new tool to investigate neurotensin signaling and cellular trafficking?
The identification of gp95sortilin, a sorting protein, as being the 100 kDa neurotensin (NT) receptor, a non-G-protein coupled receptor, constitutes a new and interesting but intriguing step in the neuropeptide signaling as well as in cellular trafficking. The isolation of the same protein by three different experimental approaches sum up the complexity for researchers involved in the functional significance of the so-called sortilin/neurotensin receptor 3 (NTR3). This review will concentrate on the putative physiological and cellular roles of sortilin/NTR3 as most results so far have proposed hypothetical conclusions rather than concrete evidence.
Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, UPR 0411, Sophia Antipolis, 660 route des Lucioles, 06560, Valbonne, France. mazella@ipmc.cnrs.fr
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D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D001921:Brain / Q000502:physiology; D019976:Cloning, Organism / Q000379:methods; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009496:Neurotensin / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology; D021381:Protein Transport / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology; D018110:Receptors, Lipoprotein; D018028:Receptors, Neurotensin / Q000378:metabolism*; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D015398:Signal Transduction / Q000502:physiology*; D000099183:Sortilin
D033942:Adaptor Proteins, Vesicular Transport; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D009496:Neurotensin; D011971:Receptors, Immunologic; D018110:Receptors, Lipoprotein; D018028:Receptors, Neurotensin; D051116:Receptors, Scavenger; D051122:Scavenger Receptors, Class B; D000099183:Sortilin; C454739:Scarb1 protein, mouse