[Histologic study of experimental spleen transplant in rats].
BACKGROUND
The objective of this paper was to demonstrate that the grafts of cervical splenic transplantation on rats using our experimental model present a normal histological appearance.


METHODS
Isogenic consanguineous Lewis rats 12 weeks old and weighing 250 gr. were used. Histological findings of a group of 25 cervical splenic grafts transplanted by means of splinting vascular venous microanastomoses and a group of 25 splenic grafts autotransplanted in the omentum were compared with a control group. The specimens were assigned according to a score of 0 to 4, following Moore's histological criteria.


RESULTS
All grafts in transplanted and autotransplanted groups had a score of 3 or 4. Then, all splenic grafts from the transplanted group had histological findings very similar to a normal spleen. In the autotransplantation group, the percentage of grafts with a score 3 (60%) was superior to the transplantation group (46%). However, the transplantation group presented a percentage of score 4 (54%), superior to the autotransplantation group (40%).


CONCLUSIONS
In our study all grafts from the cervical spleen transplantation group had histological findings very similar to a normal spleen. The percentage of spleens with histological normality in the transplantation group was superior to the autotransplantation group. However, there was no statistical significance.
Gomez
L
L
Unidad de Investigación, Facultad de Medicina de Lleida, Hospital Universitario Arnau de Vilanova, Lleida, Spain.
Egido
R
R
Guarino
G
G
Perez
L
L
Piñol
C
C
D000818:Animals; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000166:cytology* / Q000637:transplantation*; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous