Computing and visualizing electric potentials and current pathways in the thorax.
The long-term goal of electrocardiography is to relate electric potentials on the body surface with activities in the heart. Many previously reported studies have focused on direct links between heart and body surface potentials. The goals of this study were first to validate computational methods of determining volume potentials and currents with high-resolution experimental measurements and then to use interactive visualization of thoracic currents to understand features of the electrocardiographic fields from measured cardiac sources. We developed both simulation and experimental studies based on a realistic shaped torso phantom containing an isolated, perfused dog heart. Interventions included atrial pacing, single pacing and simultaneously pacing at multiple locations on the ventricles. Simulated torso volume potentials closely matched measured potentials in the torso-tank preparation (mean correlation coefficients of 0.95). Simulation further provided a means of estimating the current field in the torso from the computed torso volume potentials and the local geometric and conductive properties of the medium. Applying these techniques to the torso electric fields under a variety of pacing conditions, we have further demonstrated that thoracic current can provide many insights into the relationship between heart surface potential and body surface potentials. Specifically, we have shown that geometric factors including cardiac source configuration and location play an important role in determining to what extent electric activity in the heart is directly visible on the body surface electrocardiogram. The computation and visualization toolkit we developed in this study to explore current fields associated with cardiac events may provide new insights into electrocardiology.
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Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah, Salt Lake City 84112-5000, USA.
MacLeod
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Punske
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Taccardi
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D000200:Action Potentials; D000818:Animals; D016275:Atrial Function; D002304:Cardiac Pacing, Artificial; D003198:Computer Simulation; D004285:Dogs; D004553:Electric Conductivity; D004562:Electrocardiography; D013909:Thorax / Q000033:anatomy & histology* / Q000502:physiology; D016276:Ventricular Function