Protective role of lung surfactant protein D in a murine model of invasive pulmonary aspergillosis.
The protective effects of intranasal administration of amphotericin B (AmB), human SP-A, SP-D and a 60-kDa fragment of SP-D (rSP-D) were examined in a murine model of invasive pulmonary aspergillosis (IPA). The untreated group of IPA mice showed no survival at 7 days postinfection. Treatment with AmB, SP-D, and rSP-D increased the survival rate to 80, 60, and 80%, respectively, suggesting that SP-D (and rSP-D) can protect immunosuppressed mice from an otherwise fatal challenge with Aspergillus fumigatus conidia.
Madan
T
T
Centre for Biochemical Technology, Council for Scientific and Industrial Research, Delhi 110007, India.
Kishore
U
U
Singh
M
M
Strong
P
P
Hussain
E M
EM
Reid
K B
KB
Sarma
P U
PU
D000666:Amphotericin B / Q000627:therapeutic use; D000818:Animals; D001228:Aspergillosis / Q000188:drug therapy* / Q000276:immunology; D006023:Glycoproteins / Q000627:therapeutic use*; D008172:Lung Diseases, Fungal / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010446:Peptide Fragments / Q000627:therapeutic use; D011510:Proteolipids / Q000627:therapeutic use; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000627:therapeutic use*
D006023:Glycoproteins; D010446:Peptide Fragments; D011510:Proteolipids; D037662:Pulmonary Surfactant-Associated Protein A; D037663:Pulmonary Surfactant-Associated Protein D; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; D000666:Amphotericin B