Maternal plasma glucose at high altitude.
OBJECTIVE
To compare plasma glucose in pregnant women living at very high altitude; pregnant women living at sea level; non-pregnant women living at very high altitude; and non-pregnant women living at sea level.


METHODS
Cross-sectional study.


METHODS
Ninety-four pregnant women attending for routine antenatal care at 8-42 weeks of gestation in Cerro de Pasco, Peru which is situated 4370 m above sea level; 122 pregnant women in Lima, which is at sea level; 22 non-pregnant women in Cerro de Pasco; and 31 non-pregnant women in Lima.


METHODS
Plasma glucose concentrations were measured in samples obtained from the antecubital vein between 8 am and 10 am after an overnight period of fasting for at least 10 hours.


RESULTS
Fasting plasma glucose was lower in women at high altitude than in those at sea level, and in both groups the level was lower in pregnant women than in non-pregnant controls. The body mass index was not significantly different between all four groups, and it did not have a significant independent contribution in explaining the variance in fasting plasma glucose.


CONCLUSIONS
Women native at high altitude have lower plasma glucose concentrations before and during pregnancy than those at sea level.
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital, Denmark, Hill, London, United Kingdom.
E
E
Krampl
N A
NA
Kametas
A M
AM
Cacho Zegarra
M
M
Roden
K H
KH
Nicolaides
D000328:Adult; D000531:Altitude; D001786:Blood Glucose / Q000378:metabolism*; D015992:Body Mass Index; D003430:Cross-Sectional Studies; D005260:Female; D006400:Hematocrit; D006801:Humans; D010298:Parity; D011247:Pregnancy / Q000097:blood*; D011262:Pregnancy Trimester, Second / Q000097:blood; D012111:Residence Characteristics
D001786:Blood Glucose