Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.
We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.
Cookson
W O
WO
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. william.cookson@ndm.ox.ac.uk
Ubhi
B
B
Lawrence
R
R
Abecasis
G R
GR
Walley
A J
AJ
Cox
H E
HE
Coleman
R
R
Leaves
N I
NI
Trembath
R C
RC
Moffatt
M F
MF
Harper
J I
JI
D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D011565:Psoriasis / Q000235:genetics*