Temporary treatment with sirolimus and low-trough cyclosporine prevents acute islet allograft rejection, and combination with starch-conjugated deferoxamine promotes islet engraftment in the preclinical pig model.
Shibata
S
S
Department of Surgery at University of Minnesota, Minneapolis, Minnesota, USA.
Matsumoto
S
S
Sageshima
J
J
Hiraoka
K
K
Sutherland
D E
DE
Kirchhof
N
N
Guo
Z
Z
Koyama
K
K
Gilmore
T R
TR
Dunning
M
M
Ansite
J D
JD
Shearer
J D
JD
Clemmings
S
S
Hedlund
B E
BE
Sehgal
S N
SN
Hering
B J
BJ
D000208:Acute Disease; D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use; D003676:Deferoxamine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006084:Graft Rejection / Q000517:prevention & control*; D006085:Graft Survival / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016381:Islets of Langerhans Transplantation / Q000276:immunology*; D020123:Sirolimus / Q000627:therapeutic use; D013552:Swine; D014184:Transplantation, Homologous
D002614:Chelating Agents; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D003676:Deferoxamine; D020123:Sirolimus