Daucane sesquiterpenes from Ferula hermonis.
The roots of Ferula hermonis Boiss yielded two new daucane esters, 14-(4'-hydroxybenzoyloxy)dauc-4,8-diene (1) and 14-(4'-hydroxy-3'-methoxybenzoyloxy)dauc-4,8-diene (2), together with the four known sesquiterpenes jaeschkeanadiol p-hydroxybenzoate (3), jaeschkeanadiol benzoate (4), jaeschkeanadiol (5), and epoxyjaeschkeanadiol (6). The identities of the isolated compounds were ascertained primarily using NMR and MS data. Compounds 1 and 3 exhibited antimicrobial activity against Staphylococcus aureus with IC(50) 1.5 and 3.5 microg/mL, respectively, and against Methicillin-resistant S. aureus with IC(50) 2.0 and 4.0 microg/mL, respectively.
Galal
A M
AM
National Center for Natural Products Research, Department of Pharmacognosy, University of Mississippi, University, Mississippi 38677, USA. amgalalv@yahoo.com
Abourashed
E A
EA
Ross
S A
SA
ElSohly
M A
MA
Al-Said
M S
MS
El-Feraly
F S
FS
D000890:Anti-Infective Agents / Q000302:isolation & purification / Q000494:pharmacology; D005309:Ferula / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal; D010947:Plants, Toxic; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D000890:Anti-Infective Agents; D012717:Sesquiterpenes