Five novel neuroprotective triterpene esters of Ulmus davidiana var. japonica.
Investigation of the constituents of the stem and root barks of Ulmus davidiana var. japonica resulted in the isolation of five new triterpene esters named ulmicin A-E (1-5). Using several spectroscopic techniques, their structures were determined to be 3beta,11alpha,15alpha-trihydroxylup-20(29)-ene-11-(3'-methoxy-4'-hydroxybenzoyl ester) (1), 3beta,11alpha,15alpha-trihydroxylup-20(29)-ene-11-(4'-hydroxybenzoyl ester) (2), 3beta,11alpha,15alpha-trihydroxylup-20(29)-ene-11-(3'-methoxy-4'-hydroxybenzoyl)-15-(4'-hydroxybenzoyl ester) (3), 3beta,11alpha,15alpha-trihydroxylup-20(29)-ene-11,15-di(3'-methoxy-4'-hydroxybenzoyl ester) (4), and 3beta,11alpha,15alpha-trihydroxylup-20(29)-ene-11-(3'-methoxy-4'-hydroxybenzoyl)-15-(benzoyl ester) (5). All five compounds showed significant neuroprotective activities against glutamate-induced neurotoxicity in primary cultures of rat cortical cells.
College of Pharmacy, Seoul National University, San 56-1, Shillim-Dong, Kwanak-Gu, Seoul, 151-742, Korea.
M K
MK
Lee
Y C
YC
Kim
D000818:Animals; D002478:Cells, Cultured; D009682:Magnetic Resonance Spectroscopy; D009474:Neurons / Q000187:drug effects; D018696:Neuroprotective Agents / Q000302:isolation & purification*; D051381:Rats; D017207:Rats, Sprague-Dawley; D019685:Rosales / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D018696:Neuroprotective Agents; D014315:Triterpenes