[Concept of epidural and associated combined spinal-epidural anesthesia concerning prevention of a neurodystrophic component of intra- and postoperative complications in patients subjected to thoracic and abdominal surgery].
The stimulation of reflexogenic zones and interoreceptors in experiments and in patients during operations on the heart, lungs and organs of the gastrointestinal tract induces hyperactivation of the sympatho-adrenal system and associated with it neurogenic dystrophic alterations of the internal organs (markedly decreased level of noradrenaline, destruction of the cell ultrastructure, mitochondria in particular) and energy metabolism. The use of high epidural anesthesia as the main component of narcosis in operations on the heart (mitral commissurotomy) and on the lung prevents the development of intra- and postoperative complications, the above mentioned dystrophic alterations in particular. Similar protecting effects in the abdominal operations are obtained when using associated combined spinal-epidural anesthesia.
Zabrodin
O N
ON
Strashnov
V I
VI
D000005:Abdomen / Q000601:surgery*; D000311:Adrenal Glands / Q000502:physiology; D000767:Anesthesia, Epidural; D000775:Anesthesia, Spinal; D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology; D019616:Thoracic Surgical Procedures