Abuse of neuroleptic drug by psychiatric patients.
Due to the depaminergic neurotrasmission in the mesocortical and mesolimbic reward systems, the neuroleptic drugs have been considered free from the risk of abuse or dependence because of their antidopaminergic properties. Here, two cases of neuroleptic abuse have been described and a possibility of reward circuits other than mesocortical and mesolimbic systems operational behind this phenomenon has been postulated. There is a need to clinically recognise the abuse potential of neuroleptic drugs.
Department of Psychiatry, PGIMER, Chandigarh-160 012, India.
D
D
Basu
M
M
Marudkar
H
H
Khurana
D000328:Adult; D014150:Antipsychotic Agents / Q000627:therapeutic use; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000188:drug therapy*; D019966:Substance-Related Disorders
D014150:Antipsychotic Agents