Impact of the post-treatment conditions of parent silica on the silanization of n-octadecyl bonded silica packings in reversed-phase high-performance liquid chromatography.
Native mesoporous silica beads were subjected to a sequence of post-treatment procedure including hydrochloric acid treatment, calcination and subsequent rehydroxylation. The post-treated silica beads were converted into RP-18 silica by silanization with monochloro- and dimethoxy-n-octadecylsilanes, respectively. The influence of post-treatments and silanization conditions on the physico-chemical characteristics and on the chromatographic behaviour of the RP-silicas was studied. Also the changes of the pore structural parameters and the silanol group densities during the post-treatment and silanization were assessed.
Grossmann
F
F
Institut für Anorganische Chemie und Analytische Chemie, Johannes Gutenberg-Universität, Mainz, Germany.
Ehwald
V
V
du Fresne von Hohenesche
C
C
Unger
K K
KK
D002851:Chromatography, High Pressure Liquid / Q000295:instrumentation* / Q000379:methods; D006900:Hydroxylation; D015203:Reproducibility of Results; D012821:Silanes / Q000737:chemistry*; D012822:Silicon Dioxide / Q000737:chemistry*
D012821:Silanes; D012822:Silicon Dioxide