[Expression of adhesion molecules beta 1 integrin on the surface of fibroblasts in wound healing].
OBJECTIVE
To investigate the relationship between the expression of adhesion molecules integrin beta 1 and the synthesis of collagen in wound healing.


METHODS
In this study, integrin beta 1 expression on fibroblasts derived from granulated wound and from normal skin was compared by the technique of immunoelectron microscope and flow cytometry. The differences of ultrastructure between the two groups of fibroblasts were also observed.


RESULTS
The results showed that the expression of alpha 5 and beta 1 subunits on fibroblasts derived from granulated wound were higher than those from normal skin. Endoplasmic reticulum attached with more ribosome in the former cells was richer than that in the latter cells.


CONCLUSIONS
These results suggest that the expression of adhesion molecules integrin beta 1 appears to be associated with the synthesis of collagen in wound healing.
Department of Plastic and Reconstructive Surgery, Changzheng Hospital, Second Military Medical University, Shanghai 200003.
M
M
Chen
Z
Z
Lin
W
W
Hong
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D008297:Male; D017469:Receptors, Fibronectin / Q000096:biosynthesis*; D012867:Skin / Q000166:cytology*; D014945:Wound Healing
D017469:Receptors, Fibronectin