[Changes in the levels of acute phase proteins in viral hepatitis].
OBJECTIVE
To investigate changes in the levels of acute phase proteins (APP) in the serum of patients with acute and chronic viral hepatitis of various etiology.


METHODS
APP (prealbumin, albumin, transferrin, haptoglobin) were measured by automatic kinetic analyzer JCS II TM (Beckman) in 92 patients with acute and 61 patients with chronic viral hepatitis. Synthesis of albumin, prealbumin was depressed, of haptoglobin increased in patients with acute viral hepatitis irrespective of etiology at the height of intoxication. In chronic viral diseases APP content depended on the disease etiology. In chronic hepatitis C, B + C and D albumin, haptoglobin and transferrin were low in clinical exacerbation while in patients with chronic hepatitis B a fall in albumin, prealbumin and transferrin is accompanied with high haptoglobin.


CONCLUSIONS
A complicated multidirectional changes in APP in patients with acute or chronic hepatitis serve, on the one hand, an integral diagnostic indication of hepatic function in conditions of systemic endotoxemia. On the other hand, endotoxemia is caused by lipopolysaccharides of gram-negative bacteria entering blood flow in great amounts in morphofunctional hepatic disorders caused by viral hepatitis of different etiology.
E V
EV
Volchkova
S G
SG
Pak
V A
VA
Malov
K T
KT
Umbetova
D000328:Adult; D015415:Biomarkers / Q000097:blood; D006242:Haptoglobins / Q000378:metabolism*; D006525:Hepatitis, Viral, Human / Q000097:blood*; D006801:Humans; D011228:Prealbumin / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*; D012720:Severity of Illness Index; D014168:Transferrin / Q000378:metabolism*
D015415:Biomarkers; D006242:Haptoglobins; D011228:Prealbumin; D012709:Serum Albumin; D014168:Transferrin