Effect of sevoflurane on intracranial pressure and cardiovascular function in rabbits with experimental intracerebral haematoma.
BACKGROUND
Sevoflurane is one of the newest volatile anaesthetic agents. The effect of sevoflurane on ICP in conditions of intracranial pathology is essential from the clinical point of view but still not sufficiently clear. The aim of the study was to examine the effects of 1 MAC, 2 MAC, 3 MAC sevoflurane on intracranial pressure (ICP), mean arterial blood pressure (MABP) and heart rate (HR) in rabbits with experimental intracerebral haematoma (ICH).


METHODS
The experiments were performed in 13 adult rabbits, 3.5-4.0 kg weight. The rabbits were randomly allocated to two different groups. In group I, (n = 7), sevoflurane was administered in stepwise increasing concentrations of 2.2 vol%, 4.4 vol% and 6.6 vol%, each for a period of 15 minutes. In group II (n = 6), intracerebral haematoma was produced and subsequently sevoflurane was administered in the same manner as in group I. Ventilation parameters, inspiratory and end-tidal sevoflurane concentration, end-tidal CO2 concentration (ETCO2), HR, MABP, ICP and body temperature, measured in the nasopharynx, were monitored throughout the experiment.


RESULTS
Mean values of ETCO2 and temperature in the nasopharynx were not significantly different in both groups and remained stable in the whole observation period. In group II in all cases the evidence of intraventricular haematoma was observed. In this group mean values of ICP, MABP and HR after haematoma production were significantly higher than those in group I. Statistically significant increase of ICP was observed in 30th minute in group I, while in 35th minute in group II. In both groups a statistically significant decrease in MABP was observed from 20th minute of observation. A significant decrease in HR in both groups from 25th minute of experiment was also observed.


CONCLUSIONS
In conclusion it should be stressed that sevoflurane, in doses not exceeding 1 MAC, shows no significant effect on ICP and cardiovascular function in the course of intracranial haematoma.
Karwacki
Z
Z
Department of Anesthesiology and Intensive Therapy, Medical University of Gdansk, 7 Debinki St., 80-211 Gdańsk, Poland. zkarw@amedec.amg.gda.pl
Kowiański
P
P
Moryś
J
J
Dziewiatkowski
J
J
Kaczmarek
E
E
Suchorzewska
J
J
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D000818:Animals; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects*; D007427:Intracranial Pressure / Q000187:drug effects*; D008738:Methyl Ethers / Q000494:pharmacology*; D011817:Rabbits; D000077149:Sevoflurane
D018685:Anesthetics, Inhalation; D008738:Methyl Ethers; D000077149:Sevoflurane