Bioxanthracenes from the insect pathogenic fungus. Cordyceps pseudomilitaris BCC 1620. I. Taxonomy, fermentation, isolation and antimalarial activity.
Eleven bioxanthracenes and two monomers, six novel in nature, were isolated from the insect pathogenic fungus Cordyceps pseudomilitaris BCC 1620. Growth optimization of the strain led to the improvement of bioxanthracenes production. The bioxanthracenes were evaluated for their antimalarial activity and cytotoxicity.
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency, Bangkok, Thailand.
A
A
Jaturapat
M
M
Isaka
N L
NL
Hywel-Jones
Y
Y
Lertwerawat
S
S
Kamchonwongpaisan
K
K
Kirtikara
M
M
Tanticharoen
Y
Y
Thebtaranonth
D000818:Animals; D000873:Anthracenes / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D000962:Antimalarials / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology*; D002460:Cell Line; D005285:Fermentation; D006801:Humans; D006999:Hypocreales / Q000145:classification* / Q000378:metabolism* / Q000472:pathogenicity; D020128:Inhibitory Concentration 50; D007313:Insecta / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D010963:Plasmodium falciparum / Q000187:drug effects; D018675:Toxicity Tests
D000873:Anthracenes; D000962:Antimalarials; C423654:bioxanthracene 3