Combined liver and pancreatic islets transplantation in man using cyclosporin immunosuppression.
We report a 1-year patient and graft survival after combined liver-pancreatic islet transplantation. The patient was affected by a pancreatic neuroendocrine carcinoma with extensive liver metastasis. Native pancreas and total liver removal was undertaken after a good response to chemotherapy, and the patient was still cancer-free 1 year later. Normal liver function and insulin independence was achieved, although islet response to glucose challenge remained delayed. Immunosuppression was maintained with cyclosporin monotherapy.
Mazzaferro
V
V
Department of Surgery, Istituto Nazionale Tumori, Milan, Italy.
Socci
C
C
Regalia
E
E
Andreola
S
S
Di Bartolomeo
M
M
Bertuzzi
F
F
Di Carlo
V
V
Pozza
G
G
Doci
R
R
Bozzetti
F
F
Gennari
L
L
D016572:Cyclosporine / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007328:Insulin / Q000097:blood; D016381:Islets of Langerhans Transplantation / Q000379:methods / Q000502:physiology*; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000556:secondary / Q000601:surgery; D008297:Male; D008875:Middle Aged; D018358:Neuroendocrine Tumors / Q000601:surgery; D010190:Pancreatic Neoplasms / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D007328:Insulin; D016572:Cyclosporine