[Effect of prolonged gamma-irradiation on the functional state of heart and its adrenergic regulation at hypothyroidism].
The study of heart isolated by Langendorf's method has shown that the prolongated gamma-irradiation of euthyroid rats in 1.0 Gy dose (2.8 x 10(-7) Gy/sec) causes the decrease in contraction ability, myocardium relaxation and functional response of heart to the stimulation of beta-adrenergic receptors, and the increase in myocardium reaction to the stimulation of alpha-adrenergic receptors. The irradiation of hypothyroid animals leads to more significant and long changes in contraction function of heart and its adrenergic regulation.
Institute of Radiobiology, National Academy of Sciences of Belarus, Minsk, 220141 Belarus.
L M
LM
Lobanok
A N
AN
Antonenko
D000818:Animals; D005260:Female; D005720:Gamma Rays; D006321:Heart / Q000294:innervation / Q000503:physiopathology* / Q000528:radiation effects*; D007037:Hypothyroidism / Q000503:physiopathology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000528:radiation effects*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013997:Time Factors
D011943:Receptors, Adrenergic, beta