Indirect atomic absorption determination of atropine, diphenhydramine, tolazoline, and levamisole based on formation of ion-associates with potassium tetraiodometrcurate.
Ion-associate complexes of atropine sulphate (I), diphenhydramine HCl (II), tolazoline HCl (III) and levamisole HCl (IV) with potassium tetraiodomercurate were precipitated and their solubilities were studied as a function of pH, ionic strength and temperature. Saturated solutions of each ion-associate under the optimum precipitation conditions were prepared and the metal ion-content in the supernatant was determined. The solubility products were thus calculated at different temperatures. A new accurate and precise method using atomic absorption spectrometry for the determination of the investigated drugs in pure solutions and in pharmaceutical preparations is described. The drugs can be determined by the present method in the ranges 13.6--138.8, 5.6-58, 3.6--39.6 and 4.8--48 microg/ml solutions of I--IV, respectively.
El Ries
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National Organization for Drug Control and Research, Giza Pyramide Avenue, P.O. Box 29, Cairo, Egypt. bakaboza@hotmail.com
Khalil
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D018926:Anti-Allergic Agents / Q000032:analysis; D000959:Antihypertensive Agents / Q000032:analysis; D018501:Antirheumatic Agents / Q000032:analysis; D001285:Atropine / Q000032:analysis; D001993:Bronchodilator Agents / Q000032:analysis; D004155:Diphenhydramine / Q000032:analysis; D007454:Iodides / Q000737:chemistry*; D007978:Levamisole / Q000032:analysis; D017669:Mercury Compounds / Q000737:chemistry*; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013054:Spectrophotometry, Atomic / Q000379:methods*; D014043:Tolazoline / Q000032:analysis
D018926:Anti-Allergic Agents; D000959:Antihypertensive Agents; D018501:Antirheumatic Agents; D001993:Bronchodilator Agents; D007454:Iodides; D017669:Mercury Compounds; D004364:Pharmaceutical Preparations; D007978:Levamisole; D001285:Atropine; C009009:potassium tetraiodomercurate; D004155:Diphenhydramine; D014043:Tolazoline