Recurrent brain hemorrhage is more frequent than ischemic stroke after intracranial hemorrhage.
OBJECTIVE
To characterize the rates of recurrent intracranial hemorrhage (ICH), ischemic stroke, and death in survivors of primary ICH.


METHODS
Systematic review of studies reporting recurrent stroke in survivors of primary ICH, identified at index ICH and followed forward. Studies were identified by computerized search of the literature and review of reference lists.


RESULTS
Ten studies published between 1982 and 2000 reporting 1,880 survivors of ICH, followed for a total of 6,326 patient-years (mean follow-up, 3.4 patient-years), were included. The aggregate rate of all stroke from five studies was 4.3% per patient-year (95% CI, 3.5% to 5.4%). The rate in the three population-based studies was higher than in the two hospital-based studies, 6.2% versus 4.0% per patient-year (p = 0.04). About three fourths of recurrent strokes were ICH. Considering all 10 studies, a total of 147 patients had a recurrent ICH, an aggregate rate of 2.3% per patient-year (95% CI, 1.9% to 2.7%). Based on data from four studies, patients with a primary lobar ICH had a higher rate of recurrent ICH than those with a deep, hemispheric ICH (4.4% versus 2.1% per patient-year; p = 0.002). The aggregate rates of subsequent ischemic stroke and mortality were 1.1% per patient-year (95% CI, 0.8% to 1.7%) and 8.8% per patient-year (95% CI, 5.2% to 11.0%).


CONCLUSIONS
Recurrent stroke among survivors of primary ICH occurs at a rate of about 4% per patient-year, and most are recurrent ICH. Survivors of ICH have a higher risk of recurrent ICH than of ischemic stroke, and this has implications for the use of antithrombotic agents in these patients.
Department of Medicine (Neurology), University of Texas Health Science Center, San Antonio, TX 78229-3900, USA. baileyr@uthscsa.edu
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Bailey
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Hart
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Benavente
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Pearce
D002545:Brain Ischemia / Q000453:epidemiology* / Q000503:physiopathology*; D004812:Epidemiologic Methods; D006801:Humans; D020300:Intracranial Hemorrhages / Q000453:epidemiology* / Q000503:physiopathology*; D008875:Middle Aged; D011237:Predictive Value of Tests; D012008:Recurrence; D020521:Stroke / Q000453:epidemiology* / Q000503:physiopathology*; D013997:Time Factors