Signal transduction from bradykinin, angiotensin, adrenergic and muscarinic receptors to effector enzymes, including ADP-ribosyl cyclase.
Muscarinic acetylcholine receptors in NG108-15 neuroblastoma x glioma cells, and beta-adrenergic or angiotensin II receptors in cortical astrocytes and/or ventricular myocytes, utilize the direct signaling pathway to ADP-ribosyl cyclase within cell membranes to produce cyclic ADP-ribose (cADPR) from beta-NAD+. This signal cascade is analogous to the previously established transduction pathways from bradykinin receptors to phospholipase Cbeta and beta-adrenoceptors to adenylyl cyclase via G proteins. Upon receptor stimulation, the newly-formed cADPR may coordinately function to upregulate the release of Ca2+ from the type II ryanodine receptors as well as to facilitate Ca2+ influx through voltage-dependent Ca2+ channels. cADPR interacts with FK506, an immunosuppressant, at FKBP12.6, FK506-binding-protein, and calcineurin, or ryanodine receptors. cADPR also functions through activating calcineurin released from A-kinase anchoring protein (AKAP79). Thus, some G(q/11)-coupled receptors can control cADPR-dependent modulation in Ca2+ signaling.
Higashida
H
H
Department of Biophysical Genetics, Molecular Medicine and Bioinformatics, Kanazawa University Graduate School of Medicine, Japan.
Yokoyama
S
S
Hoshi
N
N
Hashii
M
M
Egorova
A
A
Zhong
Z G
ZG
Noda
M
M
Shahidullah
M
M
Taketo
M
M
Knijnik
R
R
Kimura
Y
Y
Takahashi
H
H
Chen
X L
XL
Shin
Y
Y
Zhang
J S
JS
D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000809:Angiotensins / Q000502:physiology*; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000378:metabolism*; D001920:Bradykinin / Q000502:physiology*; D004798:Enzymes / Q000502:physiology*; D006801:Humans; D008562:Membrane Glycoproteins; D009244:NAD+ Nucleosidase / Q000378:metabolism*; D011941:Receptors, Adrenergic / Q000502:physiology*; D011976:Receptors, Muscarinic / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D000809:Angiotensins; D015703:Antigens, CD; D000943:Antigens, Differentiation; D004798:Enzymes; D008562:Membrane Glycoproteins; D011941:Receptors, Adrenergic; D011976:Receptors, Muscarinic; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D009244:NAD+ Nucleosidase; D051997:ADP-ribosyl Cyclase 1; D001920:Bradykinin