The triangle test statistic (TTS): a test of genetic homogeneity using departure from the triangle constraints in IBD distribution among affected sib-pairs.
The proportions of affected sibs sharing 2, 1 or 0 identical by descent parental marker alleles have been shown to conform to the 'triangle constraints' (Suarez, 1978; Holmans, 1993). It has also been shown (Dudoit & Speed, 1999) that the constraints are verified provided certain assumptions hold. In this study we explore a realistic situation in which the constraints fail due to the presence of a factor in which the sibs differ, a factor on which penetrance depends. This factor may be a characteristic of the trait (severe vs. mild form), or the presence/absence of an associated trait or an environmental factor. We show that under such situations, using the triangle constraints may lead to important loss of power to detect linkage by the MLS test. We propose here an alternative approach in order to detect both linkage and heterogeneity.
Dizier
M H
MH
INSERM U535, Kremlin Bicêtre, France. dizier@kb.inserm.fr
Quesneville
H
H
Prum
B
B
Selinger-Leneman
H
H
Clerget-Darpoux
F
F
D000483:Alleles; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D005820:Genetic Testing; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D016013:Likelihood Functions; D008126:Lod Score; D008957:Models, Genetic; D015233:Models, Statistical; D009679:Nuclear Family; D010641:Phenotype; D011110:Polymorphism, Genetic
D005819:Genetic Markers