MMTV-like env gene sequences in human breast cancer.
We have previously detected an MMTV env gene-like 660 bp sequence in 38% of human breast cancers, but not in normal tissues or other tumors. In this communication we report the sequences from eleven tumors and three breast cancer cell lines, and compare them to four strains of MMTV and to the known endogenous retroviral sequences. The breast cancer sequences were highly homogenous to the MMTV's, but not to the endogenous sequences suggesting an exogenous origin.
Department of Pathology, Mount Sinai School of Medicine, New York, New York 10029, USA.
Y
Y
Wang
I
I
Pelisson
S M
SM
Melana
V
V
Go
J F
JF
Holland
B G
BG
Pogo
D000818:Animals; D001483:Base Sequence; D001943:Breast Neoplasms / Q000821:virology*; D003001:Cloning, Molecular; D016679:Genome, Viral; D006801:Humans; D008324:Mammary Tumor Virus, Mouse / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D008969:Molecular Sequence Data; D012192:Retroviridae Infections / Q000821:virology*; D016415:Sequence Alignment; D014407:Tumor Cells, Cultured; D014412:Tumor Virus Infections / Q000821:virology*; D014759:Viral Envelope Proteins / Q000235:genetics*
D014759:Viral Envelope Proteins