Bypassing IgE and targeting T cells for specific immunotherapy of allergy.
Specific immunotherapy (SIT) is a common treatment for allergic diseases. Despite its usage in clinical practice for nearly a century, more-rational and safer allergen preparations are required. Here, the underlying mechanisms and principles of allergen modification for the future use of SIT in the treatment of allergy are discussed.
Swiss Institute of Allergy and Asthma Research (SIAF), CH-7270 Davos, Switzerland. akdisac@siaf.unizh.ch
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Akdis
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Blaser
D000485:Allergens / Q000276:immunology*; D000818:Animals; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy*; D007073:Immunoglobulin E / Q000276:immunology*; D007167:Immunotherapy; D013601:T-Lymphocytes / Q000276:immunology*
D000485:Allergens; D007073:Immunoglobulin E