Susceptibility of Burkholderia cepacia and other pathogens of importance in cystic fibrosis to u.v. light.
To investigate the potential usefulness of u.v. germicidal irradiation (UVGI) in preventing the spread of Burkholderia cepacia, an important pathogen in cystic fibrosis (CF), the in-vitro susceptibility of B. cepacia to UVGI was determined. Five strains were exposed to UVGI from a 7.2-W source. Burkholderia cepacia was less susceptible to UVGI than other important CF-related pathogens, namely Staphylococcus aureus and Pseudomonas aeruginosa, but was more susceptible than Stenotrophomonas maltophilia. No strain of B. cepacia survived longer than an 8 s exposure to UVGI, with doses required to achieve 1 log reduction in bacterial numbers ranging from 28.3 to 57.5 J m(-2).
Department of Microbiology, University of Leeds, Leeds, UK.
G
G
Cairns
K G
KG
Kerr
C B
CB
Beggs
P A
PA
Sleigh
L
L
Mooney
P
P
Keig
J K
JK
Donnelly
D019121:Burkholderia Infections / Q000382:microbiology; D016956:Burkholderia cepacia / Q000528:radiation effects*; D003550:Cystic Fibrosis / Q000382:microbiology*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D011550:Pseudomonas aeruginosa / Q000528:radiation effects; D011829:Radiation Dosage; D013211:Staphylococcus aureus / Q000528:radiation effects; D014466:Ultraviolet Rays