Metformin-associated lactic acidosis.
In 1995, the oral antihyperglycemic agent, metformin, was introduced in the United States for treating diabetes mellitus. Rare cases of metformin-associated lactic acidosis caused by the accumulation of the drug in patients with renal dysfunction have been described, although a detailed time course of the resulting metabolic derangements has not been reported. A case of metformin-associated lactic acidosis is presented along with key serial laboratory abnormalities observed during the treatment phase. The patient made a complete recovery following therapy with hemodialysis and supportive care.
Detroit Receiving Hospital and Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
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Kruse
D000140:Acidosis, Lactic / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy; D000368:Aged; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects*; D008687:Metformin / Q000009:adverse effects*; D006435:Renal Dialysis
D007004:Hypoglycemic Agents; D008687:Metformin