Knockout Corner: Knockout mice for monoamine oxidase A.
A line of transgenic mice was isolated in which transgene integration had caused a deletion in the gene encoding monoamine oxidase A, an enzyme that degrades serotonin and norepinephrine. This has provided an animal model of MAOA deficiency in humans, a condition characterized by borderline mental retardation and impulsive aggression.
Institut Curie, Orsay 91405, France.
Isabelle
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Seif
Edward
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De Maeyer