Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues.
Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1,4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 microM.
Kokotos
G
G
Department of Chemistry, University of Athens, Greece. gkokotos@cc.uoa.gr
Constantinou-Kokotou
V
V
Padrón
J M
JM
Peters
G J
GJ
D000473:Alkanes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002066:Busulfan / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D020128:Inhibitory Concentration 50; D008698:Mesylates / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C429426:2-Tetradecylbutane-1,4-diol dimethanesulphonate; D000473:Alkanes; D000970:Antineoplastic Agents; D008698:Mesylates; D002066:Busulfan