[The expression of ICAM-1 on the keratinocytes in second degree human burn skin].
OBJECTIVE
To investigate the significance of changes in intercellular adhesion molecule-1 (ICAM-1) expression on keratinocytes(KCs) during wound healing of second degree burn.


METHODS
With immunohistochemistry technique, the ICAM-1 expression in second degree burn wounds in patients were investigated at four different postburn periods. The normal skins from 6 burn patients (BNG), the normal skins from 8 healthy volunteers (HVG) and the scar tissues (SG) from 8 patients served as controls.


RESULTS
There was poor expression of ICAM-1 on basal cells in normal skins of healthy volunteers, while the expression of ICAM-1 enhanced in normal skins of burn patients. On basal cells in second degree burn wounds, the expression of ICAM-1 slightly increased in the first week postburn, obviously enhanced in the second week, and in the third or fourth week, the expression continued to keep strong. In addition, the ICAM-1 in KCs showed polar distribution, and the expression of ICAM-1 markedly enhanced on the multilayer KCs in neogenetic epithelium and the positive cells arranged columnarly.


CONCLUSIONS
The enhanced expression of ICAM-1 on KCs in second degree burn wounds might be related to invasion of inflammatory cells beneath wound. It might play a role in inducing proliferation and migration of KCs and accelerating epithelization.
Burn Unit, Xijing Hospital, Fourth Military Medical University, Xi'an 710032.
X
X
Zhu
Y
Y
Li
M
M
Dong
D002056:Burns / Q000378:metabolism*; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D015603:Keratinocytes / Q000378:metabolism*; D008297:Male; D012867:Skin / Q000378:metabolism; D014945:Wound Healing
D018799:Intercellular Adhesion Molecule-1