[Sodium valproate-induced kinky hair].
BACKGROUND
We report a case of acquired progressive kinking hair, a rare pilar dysplasia. This is the first case induced by sodium valproate.


METHODS
A 6-year-old girl, treated with valproate, observed a progressive change in the texture of her hair. They were kinky, lusterless, dry and, under light microscopy, exhibited an aspect of pseudo-pili torti.


CONCLUSIONS
This child had acquired progressive kinking hair syndrome most likely induced by valproate. Five other cases of valproate-induced pilar dysplasia have been reported but without clinical descriptions.


CONCLUSIONS
We propose adding sodium valproate to the list of drugs susceptible of inducing kinky hair syndrome.
Caneppele
S
S
Service de Dermatologie, Hôpital Rangueil, Toulouse.
Mazereeuw-Hautier
J
J
Bonafé
J L
JL
D002648:Child; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D018682:GABA Agents / Q000009:adverse effects*; D006801:Humans; D007706:Menkes Kinky Hair Syndrome / Q000139:chemically induced* / Q000175:diagnosis; D014635:Valproic Acid / Q000009:adverse effects*
D018682:GABA Agents; D014635:Valproic Acid