Fluconazole dose recommendation in urinary tract infection.
OBJECTIVE
To identify the most appropriate dose of fluconazole for the treatment of symptomatic fungal urinary tract infection (UTI).


METHODS
Primary literature identified through MEDLINE (1990-June 2000). Key search terms included fluconazole and urinary tract infection.


RESULTS
Fluconazole is approved for the treatment of candidal UTIs, but dosage recommendations are not consistent. An evaluation of clinical studies of fluconazole for the treatment of candidal UTI was performed.


CONCLUSIONS
Questions remain about the optimal dosing of fluconazole, including the most appropriate dose in non-albicans species of candida as well as the optimal duration of therapy. Until further studies are performed, a fluconazole 200-mg loading dose followed by 100 mg/d for at least four days appears to be the most appropriate dose for the treatment of symptomatic candidal UTI in patients without systemic fungal infection or severe renal failure.
College of Pharmacy, The University of Texas at Austin, USA.
K S
KS
Boedeker
W J
WJ
Kilzer
D000935:Antifungal Agents / Q000009:adverse effects* / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D002986:Clinical Trials as Topic; D015725:Fluconazole / Q000008:administration & dosage* / Q000627:therapeutic use*; D006801:Humans; D009181:Mycoses / Q000188:drug therapy* / Q000382:microbiology; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000382:microbiology
D000935:Antifungal Agents; D015725:Fluconazole