Enterostatin (VPDPR) has anti-analgesic and anti-amnesic activities.
Enterostatin (VPDPR), an anorexigenic peptide derived from the amino terminus of procolipase, significantly inhibited analgesia induced by the mu-opioid agonist morphine (5 mg/kg, s.c.) after i.c.v. administration to mice at a dose of 100 nmol. On the other hand, VPDPR (approximately 200 nmol, i.c.v.) did not attenuate analgesia induced by the kappa-opioid agonist D-Phe-D-Phe-D-Nle-D-Arg-NH2 (100 microg/mouse, i.c.v.) or delta-opioid agonist DTLET (4 nmol/mouse, i.c.v.). VPDPR (100 nmol, i.c.v.) significantly improved amnesia induced by scopolamine (0.2 mg/kg, i.p.) in mice. However, VPDPR did not enhance memory in normal mice at the same dose.
Takenaka
Y
Y
Research Institute for Food Science, Kyoto University, Uji, Japan.
Nakamura
F
F
Jinsmaa
Y
Y
Lipkowski
A W
AW
Yoshikawa
M
M
D000759:Adjuvants, Anesthesia / Q000494:pharmacology; D000647:Amnesia / Q000139:chemically induced / Q000188:drug therapy*; D000701:Analgesics, Opioid / Q000037:antagonists & inhibitors*; D000818:Animals; D003089:Colipases / Q000494:pharmacology* / Q000627:therapeutic use; D004792:Enzyme Precursors; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D011498:Protein Precursors / Q000494:pharmacology* / Q000627:therapeutic use; D012601:Scopolamine / Q000494:pharmacology
D000759:Adjuvants, Anesthesia; D000701:Analgesics, Opioid; D003089:Colipases; D004792:Enzyme Precursors; D009842:Oligopeptides; D011498:Protein Precursors; C037107:procolipase; D009020:Morphine; C037653:deltakephalin; D012601:Scopolamine