Prevalence and clinical relevance of serum anti-p53 antibodies in patients with cholangiocarcinoma.
Cholangiocarcinoma (CCA) constitutes carcinoma of the bile duct found at a high prevalence in northeastern Thailand. In the present study, we examined the sera of altogether 82 Thai CCA patients for the presence of anti-p53 antibodies in order to investigate a role of the tumor suppressor gene, p53 in the carcinogenesis. Our results revealed anti-p53 antibodies in 7.3% of the cases tested, which conforms to the prevalence rate of p53 gene mutation recently reported at 5% among Thai patients. With limited number of the patients, anti-p53 antibodies were rapidly detected more frequently among patients with peripheral tumors than those with central tumors. However, further studies is required to establish significance and prognostic value of the antibodies in the context of CCA.
Department of Biochemistry, Faculty of Medicine Chulalongkorn University & Hospital, Bangkok, Thailand.
P
P
Tangkijvanich
K
K
Kasemsupatana
A
A
Janchai
P
P
Kullavanijaya
A
A
Theamboonlers
Y
Y
Poovorawan
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D000974:Antibodies, Antinuclear / Q000097:blood; D000912:Antibodies, Neoplasm / Q000097:blood*; D001650:Bile Duct Neoplasms / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D001653:Bile Ducts, Intrahepatic; D018281:Cholangiocarcinoma / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016158:Genes, p53; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D015995:Prevalence; D011379:Prognosis; D012189:Retrospective Studies; D012709:Serum Albumin / Q000378:metabolism; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000276:immunology*; D000509:alpha-Fetoproteins / Q000378:metabolism
D000974:Antibodies, Antinuclear; D000912:Antibodies, Neoplasm; D012709:Serum Albumin; D016159:Tumor Suppressor Protein p53; D000509:alpha-Fetoproteins