Tapasin: an ER chaperone that controls MHC class I assembly with peptide.
The stable assembly of MHC class I molecules with peptides in the endoplasmic reticulum (ER) involves several accessory molecules. One of these accessory molecules is tapasin, a transmembrane protein that tethers empty class I molecules to the peptide transporter associated with antigen processing (TAP). Here, evidence is presented that tapasin retains class I molecules in the ER until they acquire high-affinity peptides.
Howard Hughes Medical Institute, Dept of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232-0295, USA.
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Van Kaer
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000276:immunology; D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D017920:Antiporters / Q000276:immunology*; D004721:Endoplasmic Reticulum / Q000276:immunology*; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D026901:Membrane Transport Proteins; D018832:Molecular Chaperones / Q000276:immunology*; D010455:Peptides / Q000276:immunology*
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D017920:Antiporters; D015395:Histocompatibility Antigens Class I; D007136:Immunoglobulins; D026901:Membrane Transport Proteins; D018832:Molecular Chaperones; D010455:Peptides; C073119:TAP1 protein, human; C107762:tapasin; C071692:TAP2 protein, human