Absence of interceptive effect in rats treated with Solanum lycocarpum (St. Hil).
The interceptive effect of the powder of Solanum lycocarpum (St. Hil) (Solanaceae) fruit, used as a hypoglycemic agent by diabetic patients in Minas Gerais state (Brazil), was evaluated to observe possible effects upon zygote and pre-embryo transport in rats, since it contains solamargine and solasonine from which a 3beta-acetoxipregna-5,16-dien-20-one is obtained as well as an alkaloid with stereospecific configuration to the synthesis of steroid hormones. Inseminated rats received an aqueous suspension of 100 mg of the lobeira powder/kg of body weight, by oral gavage, from the 1st to the 4th day of pregnancy. A control group received 5 mL of distilled water in the same schedule. The pregnant rats were weighed at the beginning of treatment and on sacrifice day. Animals were killed on the 5th day of pregnancy. The oviducts and uterine horns were removed and flushed with saline solution to count expanded blastocysts. It was concluded that administration of lobeira did not cause maternal toxicity, alteration of the pre-embryo transport or reduction of the number of expanded blastocysts.
Centro de Biologia da Reprodução. Universidade Federal de Juiz de Fora, Juiz de Fora, MG, Brazil. moguerra@cbr.ufj.br
V M
VM
Peters
N L
NL
Pinheiro
J E
JE
Reis
M O
MO
Guerra
D000818:Animals; D001755:Blastocyst / Q000187:drug effects*; D005260:Female; D007004:Hypoglycemic Agents / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D019657:Solanaceae / Q000737:chemistry*; D012991:Solanaceous Alkaloids / Q000633:toxicity; D013997:Time Factors
D007004:Hypoglycemic Agents; D012991:Solanaceous Alkaloids; C026609:beta-solamarine; C026608:alpha-solamargine