Receptor activity modifying proteins.
Our understanding of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. A similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current state of knowledge of the mechanisms underlying RAMP function.
Sexton
P M
PM
Molecular Pharmacology Laboratory, Department of Pharmacology, The University of Melbourne, Victoria 3010, Australia. p.sexton@hfi.unimelb.edu.au
Albiston
A
A
Morfis
M
M
Tilakaratne
N
N
D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D019281:Dimerization; D006031:Glycosylation; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D051379:Mice; D018613:Microscopy, Confocal; D008954:Models, Biological; D008957:Models, Genetic; D008969:Molecular Sequence Data; D010455:Peptides; D010641:Phenotype; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D051381:Rats; D058261:Receptor Activity-Modifying Proteins; D018003:Receptors, Calcitonin / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism* / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution
D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D010455:Peptides; D058261:Receptor Activity-Modifying Proteins; D018003:Receptors, Calcitonin; D011956:Receptors, Cell Surface