Human neutrophil functions in obstructive jaundice.
OBJECTIVE
The effect of obstructive jaundice on neutrophil function has not been extensively studied. Therefore, the present study aimed at evaluating the effect of obstructive jaundice on human neutrophils.


METHODS
Twelve patients with obstructive jaundice due to common bile duct obstruction underwent endoscopic biliary drainage. Neutrophil functions (chemotaxis and superoxide anion generation) were evaluated before and 7 days after drainage.


RESULTS
Neutrophil chemotaxis in response to FMLP (formyl-methionyl-leucyl-phenylalanine) or interleukin-8 was abnormally increased before drainage, and was normalized after drainage. Similarly, enhanced superoxide anion generation in response to FMLP or phorbol myristate acetate before drainage was alleviated after drainage.


CONCLUSIONS
The results suggest neutrophil overactivity in patients with obstructive jaundice. The ameliorating effect of biliary drainage on neutrophil overactivity might play a role in the prevention of postoperative complications.
3rd Department of Internal Medicine, Kansai Medical University, Fumizono-cho, Moriguchi, Osaka 570-8507, Japan.
M
M
Takaoka
Y
Y
Kubota
K
K
Tsuji
S
S
Yamamoto
M
M
Ogura
K
K
Yanagitani
M
M
Shimatani
N
N
Shibatani
K
K
Inoue
D000328:Adult; D000368:Aged; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002779:Cholestasis / Q000209:etiology / Q000276:immunology* / Q000378:metabolism / Q000628:therapy; D004322:Drainage; D005260:Female; D006801:Humans; D016209:Interleukin-8 / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000276:immunology* / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D016209:Interleukin-8; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine; D013755:Tetradecanoylphorbol Acetate