Molecular dissection of autophagy: two ubiquitin-like systems.
Recent analyses of the genes required for autophagy--intracellular bulk protein degradation--in yeast have revealed two ubiquitin-like systems, both of which are involved in the membrane dynamics of the process. Molecular dissection of these systems is now revealing some surprises.
Ohsumi
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Department of Cell Biology, National Institute for Basic Biology, Myodaiji, Okazaki, 444-8585, Japan. yohsumi@nibb.ac.jp
D001343:Autophagy / Q000502:physiology*; D000071193:Autophagy-Related Protein 7; D000071190:Autophagy-Related Protein 8 Family; D008247:Lysosomes / Q000378:metabolism; D008854:Microscopy, Electron; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008954:Models, Biological; D011506:Proteins / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000502:physiology* / Q000648:ultrastructure; D029701:Saccharomyces cerevisiae Proteins; D014452:Ubiquitins / Q000378:metabolism*; D014617:Vacuoles / Q000378:metabolism
C114830:ATG7 protein, S cerevisiae; C113757:ATG8 protein, S cerevisiae; D000071190:Autophagy-Related Protein 8 Family; D008869:Microtubule-Associated Proteins; D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins; D014452:Ubiquitins; D000071193:Autophagy-Related Protein 7