Intracellular crystal formation as a mechanism of cytotoxicity in murine pulmonary Cryptococcus neoformans infection.
Rod-like crystalline structures formed during eosinophilic Cryptococcus neoformans pneumonia in C57BL/6 mice. Crystals were found associated with yeast cells and free in host cell cytoplasm. The crystals apparently formed because of the interaction of a host protein with the cryptococcal polysaccharide. Crystal formation likely contributes to pathogenesis by causing cellular damage.
Division of Infectious Diseases, Department of Medicine, Albert Einstein College of Medicine, Bronx, New York 10461, USA. feldmess@aecom.yu.edu
M
M
Feldmesser
Y
Y
Kress
A
A
Casadevall
D000818:Animals; D003453:Cryptococcosis / Q000378:metabolism / Q000473:pathology*; D003460:Crystallization; D008172:Lung Diseases, Fungal / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016253:Microscopy, Immunoelectron; D011134:Polysaccharides / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley
D011134:Polysaccharides