Herpes simplex virus 1 transmission through corneal transplantation.
Genetic characterisation of herpes simplex virus type 1 (HSV-1) DNA isolated from a donor cornea before and after corneal transplantation demonstrated the transmission of HSV-1 through transplantation. This study is the first to provide conclusive evidence for the transmission of HSV-1 by penetrating keratoplasty with subsequent reactivation of donor-derived HSV-1 in the transplanted cornea.
L
L
Remeijer
J
J
Maertzdorf
P
P
Doornenbal
G M
GM
Verjans
A D
AD
Osterhaus
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D016172:DNA Fingerprinting; D005901:Glaucoma / Q000151:congenital* / Q000601:surgery; D018259:Herpesvirus 1, Human / Q000235:genetics / Q000276:immunology; D006801:Humans; D016849:Keratitis, Herpetic / Q000276:immunology / Q000635:transmission* / Q000821:virology; D015948:Keratoplasty, Penetrating; D008297:Male; D016133:Polymerase Chain Reaction; D012086:Reoperation; D014019:Tissue Donors; D014775:Virus Activation
D000914:Antibodies, Viral