Ki-1+ anaplastic large cell lymphoma in a child with unpredictable clinical course.
Ki-1+ anaplastic large cell lymphoma (Ki-1+ ALCL) is a subtype of non-Hodgkin lymphoma (NHL) with defined histopathological characteristics but with highly variable clinical presentation and outcome. Although in most of the patients the disease behaves as an intermediate- or high-grade lymphoma, some patients present with an indolent clinical course. Factors that determine the clinical behavior of this lymphoma have not yet been identified. A case is reported of a 13-year-old girl who initially presented with Ki-1+ ALCL but later developed recurrent localized cutaneous disease and followed a clinical course similar to that of a low-grade lymphoma.
Pediatric Oncology and Bone Marrow Transplant Unit, Hospital Niño Jesus, Autonomous University of Madrid, Spain. lmadero@ctv.es
L
L
Madero
A I
AI
Benito
V
V
Quintero
M
M
Gonzalez-Vicent
M A
MA
Díaz
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D003937:Diagnosis, Differential; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008224:Lymphoma, Follicular / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D017728:Lymphoma, Large-Cell, Anaplastic / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D009361:Neoplasm Invasiveness; D016609:Neoplasms, Second Primary / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology; D012008:Recurrence; D012878:Skin Neoplasms / Q000737:chemistry / Q000188:drug therapy / Q000473:pathology