Bioresorbable polymers in trauma and bone surgery.
During the last few decades interest in resorbable polymeric materials has been steadily increasing. As with other materials for implantable devices, they have to satisfy several biological and technical requirements. Implants should maintain adequate mechanical properties in vivo for the time required and degrade at an effective rate. The conditions of polymer synthesis, further processing into implants and the sterilization process determine the mechanical properties of resorbable implants. Degradation of implants is manifested by implant fragmentation, strength loss and the decrease of polymer molecular weight. The rate of degradation and the tissue reaction are strongly affected by the material chemical composition and to some extent also by the mechanical properties. Potentially, devices made from bioresorbable polymers can overcome problems associated with metal implants like stress protection, potential for corrosion, wear and debris formation, as well as the necessity of implant removal. Resorbable polymers have proven to be good materials for a range of devices in trauma surgery. However, modifications and optimizations are still required. Three-dimensional porous scaffolds in various geometrical forms offer a good potential for the manufacture of tissue-engineered implants in the future.
Polymer Research, AO ASIF Research Institute, Clavadelerstr., CH-7270 Davos Platz.
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Gogolewski
D020341:Absorbable Implants; D001847:Bone Diseases / Q000601:surgery; D050723:Fractures, Bone / Q000601:surgery; D006801:Humans; D009984:Orthopedic Fixation Devices; D011108:Polymers / Q000737:chemistry*; D013242:Sterilization
D011108:Polymers