[Effect of fractions of the cerebrospinal fluid from patients with drug dependence on basic electrophysiological characteristics of the rat olfactory cortex slices].
Heroin addicts at the initial stage of abstinence syndrome were subjected to detoxication by liquorosorption technique. The fractions of their cerebrospinal fluid obtained by the thin layer chromatography technique were analyzed. The substances extracted from the cerebrospinal fluid of drug addicts, presumably peptides, negatively affected the conductive function and synaptic transmission in surviving slices of the olfactory cortex of rats. The conclusion was drawn about a possibility of application of surviving rat brain slices as test object for estimation of the extent of purification of the cerebrospinal fluid from toxic endogenous substances after the liquorosorption.
Pavlov Institute of Physiology, Russian Academy of Sciences, St.-Petersburg.
P A
PA
Pirumov
V G
VG
Shaiapina
A A
AA
Mokrushin
D Iu
DIu
Romanovskiĭ
M A
MA
Flerov
D000293:Adolescent; D000328:Adult; D000818:Animals; D001685:Biological Factors / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D005591:Chemical Fractionation; D002855:Chromatography, Thin Layer; D004594:Electrophysiology; D006556:Heroin Dependence / Q000134:cerebrospinal fluid*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009833:Olfactory Pathways / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects
D001685:Biological Factors