Antifungal activity of bicyclic heterocyclic-1,2-diazole.
A novel series of heterocyclic-1,2 diazole namely N1-iso nicotinoyl-5,5'-dimethyl cyclohexane-4-(sulpha/substituted phenylazo)-1,2-diazoles have been synthesized. The compounds were screened for the anti-fungal properties against building fungi. The fungal species used for this purpose were Aspergillus niger and Pencillium frequentans. It was found that out of a series of 25 compounds, fourteen have shown significant fungicidal properties against both the above species. Minimum inhibition concentration was observed between 100 and 200 ppm for most of the compounds.
Singh
Y
Y
Building Pests & Mycology Laboratory Central Building Research Institute, Roorkee 247 667, India.
Chaurasia
L
L
Nayal
S S
SS
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D001234:Aspergillus niger / Q000187:drug effects; D001393:Azoles / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D010407:Penicillium / Q000187:drug effects; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D001393:Azoles