Preliminary data on an association between blood groups and serum markers used for the so-called "triple screening": free oestriol MoM values are decreased in rhesus-negative (Rh-) women.
The serum markers human chorionic gonadotrophin (hCG), alpha-fetoprotein (AFP) and unconjugated oestriol (uE3) in 606 rhesus-negative (Rh-) women have been compared with 18 960 controls. There were no significant differences in the distribution of hCG and AFP between these two cohorts. However the uE3 values in Rh- women were significantly lowered (median: 0.85 MoM).
Sancken
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Institute of Human Genetics, University of Goettingen, Heinrich-Dueker-Weg 12, D-37037 Goettingen, Germany. usancke@gwdg.de
Bartels
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D015415:Biomarkers / Q000097:blood*; D016022:Case-Control Studies; D006063:Chorionic Gonadotropin / Q000097:blood; D004314:Down Syndrome / Q000097:blood* / Q000175:diagnosis*; D004964:Estriol / Q000097:blood; D005260:Female; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods; D012204:Rh-Hr Blood-Group System; D000509:alpha-Fetoproteins / Q000378:metabolism
D015415:Biomarkers; D006063:Chorionic Gonadotropin; D012204:Rh-Hr Blood-Group System; D000509:alpha-Fetoproteins; D004964:Estriol