Importance of the C28-C38 hydrophobic domain of okadaic acid for potent inhibition of protein serine-threonine phosphatases 1 and 2A.
Okadaic acid is a potent inhibitor of select serine/threonine protein phosphatases. The importance of the C28-C38 hydrophobic domain of okadaic acid for inhibition of PP1 and PP2A was investigated. The hydrophobic domain is required but not sufficient for potent inhibition, and it also contributes to differential inhibition between PP1 and PP2A.
Frydrychowski
V A
VA
Department of Chemistry, University of Minnesota, Minneapolis 55455, USA.
Urbanek
R A
RA
Dounay
A B
AB
Forsyth
C J
CJ
D004791:Enzyme Inhibitors / Q000737:chemistry*; D008968:Molecular Conformation; D015394:Molecular Structure; D019319:Okadaic Acid / Q000031:analogs & derivatives / Q000737:chemistry*; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism
D004791:Enzyme Inhibitors; D019319:Okadaic Acid; D010749:Phosphoprotein Phosphatases