Expression of phosphatidylinositol-3 kinase in lung cancer.
The expression of phosphatidylinositol-3 kinase in tumors and homologous tissues from 29 patients with lung cancer, 5 patients with lung metastases of various tumors, and some non-tumorous pulmonary diseases was studied by Western blot analysis. The expression of phosphatidylinositol-3 kinase was increased in these tumors in comparison with histologically intact lung tissue in 5 patients with non-small-cell cancer. In 20 patients expression of phosphatidylinositol-3 kinase was the same as in homologous tissue and in 4 patients it was decreased. No relationship between phosphatidylinositol-3 kinase expression and clinical and morphological characteristics of lung cancer was revealed.
N. N. Blokhin Cancer Research Center, Russian Academy of Medical Sciences, Moscow. es-gershtein@mtu-net.ru
E S
ES
Gershtein
V A
VA
Shatskaya
K K
KK
Laktionov
N E
NE
Kushlinskii
M A
MA
Krasil'nikov
D000230:Adenocarcinoma / Q000201:enzymology / Q000556:secondary; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000201:enzymology; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000556:secondary; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000201:enzymology; D008175:Lung Neoplasms / Q000201:enzymology* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*
D019869:Phosphatidylinositol 3-Kinases