[Effect of prolonged gamma-irradiation on the functional state of heart and its adrenergic regulation at hypothyroidism].
The study of heart isolated by Langendorf's method has shown that the prolongated gamma-irradiation of euthyroid rats in 1.0 Gy dose (2.8 x 10(-7) Gy/sec) causes the decrease in contraction ability, myocardium relaxation and functional response of heart to the stimulation of beta-adrenergic receptors, and the increase in myocardium reaction to the stimulation of alpha-adrenergic receptors. The irradiation of hypothyroid animals leads to more significant and long changes in contraction function of heart and its adrenergic regulation.
Lobanok
L M
LM
Institute of Radiobiology, National Academy of Sciences of Belarus, Minsk, 220141 Belarus.
Antonenko
A N
AN
D000818:Animals; D005260:Female; D005720:Gamma Rays; D006321:Heart / Q000294:innervation / Q000503:physiopathology* / Q000528:radiation effects*; D007037:Hypothyroidism / Q000503:physiopathology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000528:radiation effects*; D051381:Rats; D011943:Receptors, Adrenergic, beta / Q000502:physiology*; D013997:Time Factors
D011943:Receptors, Adrenergic, beta