Vitamin E and the prevention of atherosclerosis.
Successful strategy for the prevention of coronary heart disease (CHD) in particular of atherosclerosis, require a detailed understanding of the underlying mechanism. It is now being recognised that dietary antioxidants, in particular vitamin E, will play an important role in designing future strategies. Although more and more beneficial effects of vitamin E on atherosclerosis are being described, the biochemical and cell biological mechanism underlying these benefits are not yet fully understood, preventing the use of vitamin E as therapeutic agent. Recent new findings have shed new light on the physiological role of vitamin E and suggest that it has a much broader array of biological activities than originally expected. In addition to its well described role as an antioxidant, it is becoming evident that vitamin E also can modulate the immune system, suppress local and chronic inflammation, reduce blood coagulation and thrombus formation, and enhance cell function and survival. This review summarises new findings from in vitro studies and discusses their potential relevance in human atherosclerosis.
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Institute of Physiology, Vesalgasse 1, CH-4051 Basel.
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D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000627:therapeutic use; D000975:Antioxidants / Q000008:administration & dosage / Q000627:therapeutic use; D017209:Apoptosis; D001161:Arteriosclerosis / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000502:physiology; D016166:Free Radical Scavengers; D006801:Humans; D007962:Leukocytes / Q000502:physiology; D008077:Lipoproteins, LDL / Q000378:metabolism; D008264:Macrophages / Q000502:physiology; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000975:Antioxidants; D016166:Free Radical Scavengers; D008077:Lipoproteins, LDL; D014810:Vitamin E