Enantioselective synthesis of epigallocatechin-3-gallate (EGCG), the active polyphenol component from green tea.
[reaction: see text]. Enantioselective synthesis of epigallocatechin-3-gallate (EGCG, 3b), the active polyphenol component from green tea, has been achieved by using a stereospecific cyclization of the Sharpless asymmetric dihydroxylation product 7c as the key step.
Department of Chemistry, McGill University, Montreal, Quebec H3A 2K6, Canada.
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D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D002392:Catechin / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D010084:Oxidation-Reduction; D013237:Stereoisomerism; D013662:Tea / Q000737:chemistry*
D000972:Antineoplastic Agents, Phytogenic; D013662:Tea; D002392:Catechin; C045651:epigallocatechin gallate