Palladium-catalyzed allylic alkylation using chiral hydrazones as ligands.
Palladium-catalyzed asymmetric allylic alkylation of 1,3-diphenyl-2-propenyl acetate (4) with a dimethyl malonate-BSA-LiOAc system and its derivatives has been successfully carried out in the presence of a new chiral hydrazone ligands such as 2-(diphenylphosphino)benzaldehyde SAMP hydrazone (DPPBA-SAMP) (3a) in high yields with high enantioselectives.
Department of Materials Technology, Faculty of Engineering, Chiba University, Inage-ku, Chiba 263-8522, Japan. tmino@planet.tc.chiba-u.ac.jp
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T
Mino
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M
Shiotsuki
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N
Yamamoto
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Suenaga
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Sakamoto
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Fujita
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Yamashita