[Blood determination of benzathine-penicillin used in acute joint rheumatism prophylaxis].
Our actual work studies the effectiveness in vivo of the Benzathin penicillin that is realized on 88 subjects suffering from a stable rheumatic fever. It has shown that: The first hours after an intramuscular injection, the benzathin penicillin is found at an efficient concentration superior to 0.02 ug/ml at the level of the blood. The highest dose in the blood is obtained the first 24 hours. The amount of antibiotic at the level of the blood is very efficient during 4 weeks.
Laboratoire National de Référence et de Recherche Streptocoques RAA Institut Pasteur d'Algérie.
B
B
Merad
H
H
Berrah
N
N
Miloudi
S
S
Sami
K
K
Hireche
S
S
Kermi
M
M
Issad
H
H
De Montclos
D000208:Acute Disease; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D010401:Penicillin G Benzathine / Q000097:blood* / Q000627:therapeutic use; D010406:Penicillins / Q000097:blood* / Q000627:therapeutic use; D012213:Rheumatic Fever / Q000097:blood* / Q000517:prevention & control*; D013997:Time Factors
D010406:Penicillins; D010401:Penicillin G Benzathine