Role of S-adenosyl-L-methionine in potentiating cadmium mobilization by diethylenetriamine penta acetic acid in mice.
The beneficial effects of S-adenosyl-L-methionine (SAM) in potentiating the mobilization of cadmium by cadmium trisodium diethylenetriamine penta acetic acid (DTPA) from the major target organs and restoration of depleted tissue glutathione (GSH), zinc and copper concentration, were determined in cadmium-exposed mice. The results indicated a significant depletion of cadmium concentration from the blood in DTPA plus SAM treated animals compared with DTPA or SAM alone treated groups. The treatment with SAM alone was also effective in correcting the zinc and GSH concentrations. The results indicated few beneficial effects of concomitant SAM administration during chelation of cadmium with DTPA.
School of Studies in Zoology, Jiwaji University, Gwalior, India.
U
U
Gubrelay
R
R
Mathur
G M
GM
Kannan
S J
SJ
Flora
D000818:Animals; D002104:Cadmium / Q000037:antagonists & inhibitors* / Q000493:pharmacokinetics; D002105:Cadmium Poisoning / Q000188:drug therapy*; D002614:Chelating Agents / Q000008:administration & dosage*; D003300:Copper / Q000493:pharmacokinetics; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005978:Glutathione / Q000493:pharmacokinetics; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D004369:Pentetic Acid / Q000008:administration & dosage*; D012436:S-Adenosylmethionine / Q000008:administration & dosage*; D013154:Spleen / Q000378:metabolism; D015032:Zinc / Q000493:pharmacokinetics
D002614:Chelating Agents; D002104:Cadmium; D003300:Copper; D004369:Pentetic Acid; D012436:S-Adenosylmethionine; D005978:Glutathione; D015032:Zinc