Comparison the cognitive effect of anti-epileptic drugs in seizure-free children with epilepsy before and after drug withdrawal.
We studied the cognitive effects of antiepileptic drugs (AED), by investigating epileptic children who were seizure-free for at least 2 years and who had undergone fixed monotherapy. Seventy consecutive epileptic children (25 with carbamazepine (CBZ), 22 with phenobarbital (PB), and 23 with valproate (VPA)) were examined by Wechsler Intelligence Scale for Children-Revised (WISC-R) and auditory event-related potentials (P(300)) at three sessions: before AED reduction, then 1 and 7 months after complete withdrawal of treatment. There were no significant differences in IQ and subtests scores of WISC-R in any group at any of the three sessions. P(300) latencies were significantly increased in the children receiving PB but not in children receiving CBZ or VPA. P(300) amplitudes were increased but not significantly different among the three groups. These findings suggest that PB may affect cognitive function on children, but the changes of P(300) latencies may improve after discontinuation.
Department of Pediatrics, College of Medicine, National Cheng Kung University, 138 Sheng-Li Road, 70428, Tainan, Taiwan, ROC. PCYJ.mail.ncku.edu.tw
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Chen
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Chi Chow
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Lee
D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D002220:Carbamazepine / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D003071:Cognition / Q000187:drug effects* / Q000502:physiology; D004827:Epilepsy / Q000188:drug therapy / Q000523:psychology*; D018913:Event-Related Potentials, P300 / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology* / Q000627:therapeutic use; D012189:Retrospective Studies; D014635:Valproic Acid / Q000494:pharmacology / Q000627:therapeutic use; D014888:Wechsler Scales / Q000706:statistics & numerical data*
D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid; D010634:Phenobarbital