Cyclopenta-polycyclic aromatic hydrocarbons: potential carcinogens and mutagens.
Cyclopenta-polycyclic aromatic hydrocarbons (cyclopenta-PAHs) are a group of compounds that have been detected as environmental pollutants. Perturbation molecular orbital (PMO) calculations on their presumed ultimate carcinogenic metabolites, the cyclopenta-PAH expoxides, predict that they may have a greater biological hazard than the classic PAHs.
National Center for Toxicological Research, Jefferson, AR 72079, USA.
P P
PP
Fu
F A
FA
Beland
S K
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Yang
D000818:Animals; D002273:Carcinogens / Q000737:chemistry / Q000633:toxicity*; D003517:Cyclopentanes / Q000737:chemistry / Q000633:toxicity*; D004852:Epoxy Compounds / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D015394:Molecular Structure; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D011084:Polycyclic Aromatic Hydrocarbons / Q000737:chemistry* / Q000633:toxicity; D013329:Structure-Activity Relationship
D002273:Carcinogens; D003517:Cyclopentanes; D004852:Epoxy Compounds; D009153:Mutagens; D011084:Polycyclic Aromatic Hydrocarbons