Serum free carnitine and total triglycerid levels in children with iron deficiency anemia.
Iron deficiency anemia and hyperlipidemia are common public health problems in Turkey. The connection between iron and lipid metabolisms has not been clarified yet. The aim of the study was to determine the effect of iron deficiency on carnitine and lipid metabolism. Study group was consisted of 70 children (mean age 14.7 +/- 1.3 months) suffering from iron deficiency anemia and 20 healthy children (mean age 13.7 +/- 1.2 months) attended to outpatient clinics of Cumhuriyet University, Sivas were enrolled the study as the control group. Assessments of serum free carnitine concentrations, total triglyceride, total cholesterol and VLDL levels were made in both groups. The mean serum free carnitine concentration was significantly lower than the control group (18.9 +/- 0.43 nmol/ml and 45.9 +/- 1.47 nmol/ml respectively, t = 17.5 p < 0.01). Results of our study also indicated higher serum total triglyceride, total cholesterol and VLDL levels in iron deficient patients than the healthy controls. Regression analyses indicated a negative correlation between serum free carnitine and total triglyceride levels in iron deficient patients. This study confirms that iron deficiency anemia may be linked to the endogenous carnitine synthesis in pediatric age group, and thus hyperlipidemia appears to be a risk factor for premature cardiovascular diseases.
Cumhuriyet University, Faculty of Medicine, Sivas.
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Sekreter
D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D002331:Carnitine / Q000097:blood / Q000378:metabolism*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000453:epidemiology / Q000503:physiopathology; D007223:Infant; D050356:Lipid Metabolism; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D012044:Regression Analysis; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood*; D014421:Turkey
D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol; D002331:Carnitine