Acetylcholinesterase--new roles for an old actor.
The discovery of the first neurotransmitter--acetylcholine--was soon followed by the discovery of its hydrolysing enzyme, acetylcholinesterase. The role of acetylcholinesterase in terminating acetylcholine-mediated neurotransmission made it the focus of intense research for much of the past century. But the complexity of acetylcholinesterase gene regulation and recent evidence for some of the long-suspected 'non-classical' actions of this enzyme have more recently driven a profound revolution in acetylcholinesterase research. Although our understanding of the additional roles of acetylcholinesterase is incomplete, the time is ripe to summarize the evidence on a remarkable diversity of acetylcholinesterase functions.
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D000110:Acetylcholinesterase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017398:Alternative Splicing / Q000235:genetics; D000818:Animals; D002448:Cell Adhesion; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D006410:Hematopoiesis; D006801:Humans; D009097:Multienzyme Complexes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D009154:Mutation / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000201:enzymology / Q000235:genetics; D009474:Neurons / Q000201:enzymology / Q000378:metabolism; D018923:Persian Gulf Syndrome / Q000201:enzymology; D010641:Phenotype; D058225:Plaque, Amyloid / Q000378:metabolism; D021381:Protein Transport; D013312:Stress, Physiological / Q000201:enzymology; D013569:Synapses / Q000201:enzymology / Q000378:metabolism
D002800:Cholinesterase Inhibitors; D009097:Multienzyme Complexes; D000110:Acetylcholinesterase; D004298:Dopamine