Teratological studies in defatted jojoba meal-supplemented rats.
To look for possible developmental effects in the offspring of jojoba meal-treated Wistar rats, and to distinguish between the effects of reduced food intake and the specific developmental effects of jojoba meal itself, mated female rats were divided into three groups of 20 rats. They received during gestation: (a) normal rodent food (control group); (b) normal rodent food supplemented with 3% defatted jojoba meal (jojoba group); or (c) normal rodent food pair-fed with the jojoba group (pair-fed group). The jojoba meal group showed approximately 30% inhibition of food intake. Ten rats from each group were killed on gestation day 21. Compared to the control group, foetal body weight was reduced in both the jojoba and pair-fed groups, with a greater reduction in the jojoba group. Skeletal ossification was retarded to the same extent in both the jojoba and pair-fed groups. The other 10 rats from each group were left to produce litters. Compared with controls, the body weight of the pups was lower in both the jojoba and pair-fed groups; the reduction was slightly greater in the jojoba group, but this difference disappeared after 1 week. The offspring showed no other abnormalities and reproduced normally. We conclude that, at the dose used, the retardation in foetal skeletal ossification, induced by jojoba meal supplementation during gestation, is due to food intake inhibition. Moreover, the lower birth weight of the young of jojoba-treated dams compared with the pair-fed group is merely due to a lower body weight gain during gestation.
Cokelaere
M
M
Interdisciplinary Research Centre, Katholieke Universiteit Leuven Campus Kortrijk, E. Sabbelaan 53, B-8500, Kortrijk, Belgium. marnix.cokelaere@kulak.ac.be
Flo
G
G
Lievens
S
S
Van Boven
M
M
Vermaut
S
S
Decuypere
E
E
D000014:Abnormalities, Drug-Induced / Q000473:pathology; D000818:Animals; D004032:Diet; D004435:Eating / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D009999:Ossification, Heterotopic / Q000139:chemically induced / Q000473:pathology; D010944:Plants / Q000737:chemistry*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D013723:Teratogens / Q000633:toxicity*; D015430:Weight Gain / Q000187:drug effects
D013723:Teratogens