Induction of cell-associated chemokines after endotoxin administration to healthy humans.
Erythrocytes express the Duffy antigen receptor for chemokines. Endotoxin injection into humans induced high levels of interleukin-8 (IL-8), growth-related oncogene alpha, and monocyte chemoattractant protein 1 in circulating erythrocytes. IL-8 was also recovered from mononuclear and polymorphonuclear cells. Cell-associated chemokines may more accurately reflect their production than plasma concentrations.
Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
D P
DP
Olszyna
E
E
De Jonge
P E
PE
Dekkers
S J
SJ
van Deventer
T
T
van der Poll
D000328:Adult; D001773:Blood Cells / Q000378:metabolism; D018932:Chemokine CCL2 / Q000096:biosynthesis; D054407:Chemokine CCL4; D054360:Chemokine CXCL1; D018925:Chemokines / Q000096:biosynthesis*; D019743:Chemokines, CXC; D002630:Chemotactic Factors / Q000096:biosynthesis; D006133:Growth Substances / Q000096:biosynthesis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D016209:Interleukin-8 / Q000096:biosynthesis; D008070:Lipopolysaccharides / Q000633:toxicity*; D019402:Macrophage Inflammatory Proteins / Q000096:biosynthesis
C475829:CXCL1 protein, human; D018932:Chemokine CCL2; D054407:Chemokine CCL4; D054360:Chemokine CXCL1; D018925:Chemokines; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D016209:Interleukin-8; D008070:Lipopolysaccharides; D019402:Macrophage Inflammatory Proteins