New advances in ligand design for synthetic modeling of metalloprotein active sites.
Judicious control of ligand steric bulk and auxiliary structural elements enables the construction of novel synthetic complexes that model the properties of metalloprotein active sites, thus providing insight into their structure and function. Major recent developments include the synthesis of a number of unusual and biologically relevant complexes of copper and iron using elaborate N-donor and O-donor ligands.
Department of Chemistry and Center for Metals in Biocatalysis, University of Minnesota, Minneapolis 55455, USA. tolman@chem.umn.edu
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D001565:Benzoates / Q000737:chemistry; D001665:Binding Sites; D003300:Copper / Q000737:chemistry*; D003576:Electron Transport Complex IV / Q000737:chemistry*; D007501:Iron / Q000737:chemistry*; D008024:Ligands; D008667:Metalloproteins / Q000138:chemical synthesis* / Q000737:chemistry*; D008956:Models, Chemical; D008968:Molecular Conformation
D001565:Benzoates; D008024:Ligands; D008667:Metalloproteins; D003300:Copper; D007501:Iron; D003576:Electron Transport Complex IV