Sarcomatoid chordoma: chordoma with a massive malignant spindle-cell component.
We report a case of chordoma containing a spindle cell sarcomatoid component with a gradual transition from conventional chordoma. Immunohistochemically, many tumor cells in both conventional chordoma and sarcomatoid components were positive for cytokeratins (AE1/AE3, CAM5.2) and epithelial membrane antigen as well as vimentin. This report provides a rare example of sarcomatoid chordoma. Familiarity with this type of bone tumor should help to avoid confusion with dedifferentiated chordoma and other spindle cell sarcomas or carcinomas.
Morimitsu
Y
Y
Department of Pathology and Oncology, School of Medicine, University of Occupational and Environmental Health, Japan.
Aoki
T
T
Yokoyama
K
K
Hashimoto
H
H
D000368:Aged; D001706:Biopsy; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000532:radiotherapy; D002817:Chordoma / Q000175:diagnosis* / Q000532:radiotherapy; D003937:Diagnosis, Differential; D018450:Disease Progression; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D012447:Sacrum / Q000000981:diagnostic imaging / Q000473:pathology; D012509:Sarcoma / Q000175:diagnosis* / Q000532:radiotherapy; D014057:Tomography, X-Ray Computed