Escherichia coli DnaA protein--phospholipid interactions: in vitro and in vivo.
DNA replication in Escherichia coli is controlled at the initiation stage, possibly by regulation of the essential activity of DnaA protein. The cellular membrane has long been hypothesized to be involved in chromosomal replication. Accumulating evidence, both in vitro and in vivo, that supports the importance of membrane phospholipids influencing the initiation activity of DnaA is reviewed.
Department of Biochemistry and Molecular Biology, Georgetown University Medical Center, Washington, DC 20007, USA. crooke@bc.georgetown.edu
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D000255:Adenosine Triphosphate / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D004261:DNA Replication; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D004926:Escherichia coli / Q000235:genetics* / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D010743:Phospholipids / Q000378:metabolism*; D017434:Protein Structure, Tertiary; D018741:Replication Origin / Q000235:genetics; D012093:Replicon
D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C066312:DnaA protein, Bacteria; D010743:Phospholipids; D000255:Adenosine Triphosphate