Optimizing drug delivery to the lung: design of a CFC-free corticosteroid metered-dose aerosol system.
The mandatory replacement of chlorofluorocarbons (CFCs) with ozone-friendly propellants, such as hydrofluoroalkanes (HFAs), has provided an opportunity to optimize aerosol design and improve drug delivery to pulmonary tissue. Asthma is an inflammatory disorder of the lungs that appears to affect both small and large airways, so ideally, inhaled corticosteroid should reach both central and peripheral sites. This review considers the development of an aerosol system containing beclomethasone dipropionate in hydrofluoroalkane-134a (HFA) propellant (Qvar, 3M Health Care, Loughborough, UK) designed to target medication delivery throughout the bronchopulmonary tree and to improve the therapeutic ratio (topical efficacy: systemic safety), thereby offering potential clinical benefits to asthma patients.
Donnell
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3M Health Care, Loughborough, Leicestershire, UK. ddonnell@mmm.com
D000280:Administration, Inhalation; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage*; D000335:Aerosol Propellants; D000336:Aerosols; D017402:Chlorofluorocarbons; D016503:Drug Delivery Systems; D006801:Humans; D008168:Lung / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D000335:Aerosol Propellants; D000336:Aerosols; D017402:Chlorofluorocarbons