Industrial biocatalysis.
The number of industrial processes for the synthesis of fine and commodity chemicals, pharmaceutical and agrochemical intermediates and drug substances utilizing biological catalysts continues to grow. The combination of new molecular biology techniques, such as directed evolution and pathway engineering, with new and efficient high-throughput screening methods is poised to bolster this field and further advance the contribution of biocatalysis to the chemical and the pharmaceutical industries.
Schering-Plough Research Institute, Union, New Jersey 07083, USA. alex.zaks@spcorp.com
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D002384:Catalysis; D002617:Chemical Industry / Q000379:methods* / Q000639:trends; D019020:Directed Molecular Evolution / Q000379:methods; D004345:Drug Industry / Q000379:methods* / Q000639:trends; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D005818:Genetic Engineering / Q000379:methods; D006540:Herbicides / Q000138:chemical synthesis; D006836:Hydro-Lyases / Q000737:chemistry / Q000378:metabolism; D010399:Penicillin Amidase / Q000737:chemistry / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000138:chemical synthesis*
D004798:Enzymes; D006540:Herbicides; D004364:Pharmaceutical Preparations; D010399:Penicillin Amidase; D006836:Hydro-Lyases; C048831:nitrile hydratase