The histopathological effects of thiodan on the liver and gut of mosquitofish, Gambusia affinis.
Thiodan (33.7% endosulfan), a polychlorinated cyclodiene insecticide, was evaluated for its histopathological effects on mosquitofish, Gambusia affinis, by light microscopy. Fish were exposed to doses of 0.00 (control), 1.00, 2.50, and 5.00 microg/L on days 7, 14, 21, and 30. No histopathological effects were apparent at control group. The histopathological alterations were characterized as oedema, degeneration, accumulation of lymphocytes in the lamina propria, disintegration of villuses, pycnotic state of nuclei, and necrosis in gut; degeneration, hypertrophy, sinusoids enlargement, hemorrhage, pycnosis position of nuclei, vacuolization of cell cytoplasm, infiltration of mononuclear lymphocyte, and congestion in liver. These alterations were time- and dose-dependent.
Cengiz
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EI
Department of Biology, Faculty of Science and Art, Dicle University, Diyarbakir, Turkey.
Unlü
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E
Balci
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K
D000818:Animals; D003532:Cyprinodontiformes / Q000254:growth & development*; D004064:Digestive System / Q000187:drug effects / Q000473:pathology*; D004305:Dose-Response Relationship, Drug; D004726:Endosulfan / Q000633:toxicity*; D006843:Hydrocarbons, Chlorinated; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D013997:Time Factors
D006843:Hydrocarbons, Chlorinated; D007306:Insecticides; D004726:Endosulfan