Where is 'dorsal V4' in human visual cortex? Retinotopic, topographic and functional evidence.
In flattened human visual cortex, we defined the topographic homologue of macaque dorsal V4 (the 'V4d topologue'), based on neighborhood relations among visual areas (i.e. anterior to V3A, posterior to MT+, and superior to ventral V4). Retinotopic functional magnetic resonance imaging (fMRI) data suggest that two visual areas ('LOC' and 'LOP') are included within this V4d topologue. Except for an overall bias for either central or peripheral stimuli (respectively), the retinotopy within LOC and LOP was crude or nonexistent. Thus the retinotopy in the human V4d topologue differed from previous reports in macaque V4d. Unlike some previous reports in macaque V4d, the human V4d topologue was not significantly color-selective. However, the V4d topologue did respond selectively to kinetic motion boundaries, consistent with previous human fMRI reports. Because striking differences were found between the retinotopy and functional properties of the human topologues of 'V4v' and 'V4d', it is unlikely that these two cortical regions are subdivisions of a singular human area 'V4'.
Nuclear Magnetic Resonance Center, Department of Radiology, Massachusetts General Hospital, Charlestown, MA 02129, USA. tootell@nmr.mgh.harvard.edu
R B
RB
Tootell
N
N
Hadjikhani
D000818:Animals; D001931:Brain Mapping / Q000379:methods*; D005584:Fovea Centralis / Q000502:physiology; D006801:Humans; D008251:Macaca; D008279:Magnetic Resonance Imaging; D010775:Photic Stimulation / Q000379:methods; D012160:Retina / Q000502:physiology; D013045:Species Specificity; D014793:Visual Cortex / Q000502:physiology*; D014794:Visual Fields / Q000502:physiology*