Long-term changes in off-lesion endocochlear potential after induction of localized lesions in the lateral wall.
Localized lesions were produced in various turns of the guinea pig cochlea by means of a photochemical reaction between systemically administered rose bengal dye and green light illumination. The endocochlear potential (EP) was measured at various off-lesion sites, and a morphological examination was performed. In a previous study, this same investigation was done at 3 days, at which time all sites apical to the lesion showed significant EP depression, and damage to the stria vascularis at the lesion was ongoing. In the present 2-week study, the apical EP values were not different from the basal values, and all experimental values were essentially the same as the EP values found in control animals. Morphological examination revealed that the previously damaged structures were greatly repaired. Localized damage and early apical EP depression followed by damage repair and eventual EP recovery could account for the clinical course of certain cases of idiopathic sudden hearing loss involving low-tone deafness.
Department of Otolaryngology, Hamamatsu University School of Medicine, Japan.
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R
Wu
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Hoshino
D000818:Animals; D003051:Cochlea / Q000503:physiopathology*; D005071:Evoked Potentials; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D013997:Time Factors