Synthesis and antitumor activity of novel paclitaxel-chlorambucil hybrids.
The syntheses and antitumor activity of three paclitaxel-chlorambucil hybrids are presented. Hybrid 3 showed significant in vivo efficacy.
Discovery Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660, USA. mark.wittman@bms.com
M D
MD
Wittman
J F
JF
Kadow
D M
DM
Vyas
F L
FL
Lee
W C
WC
Rose
B H
BH
Long
C
C
Fairchild
K
K
Johnston
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000737:chemistry / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000494:pharmacology; D002699:Chlorambucil / Q000737:chemistry / Q000494:pharmacology; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D020128:Inhibitory Concentration 50; D051379:Mice; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000188:drug therapy; D017239:Paclitaxel / Q000737:chemistry / Q000494:pharmacology; D012509:Sarcoma / Q000188:drug therapy; D014407:Tumor Cells, Cultured; D023041:Xenograft Model Antitumor Assays
D000970:Antineoplastic Agents; D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D002699:Chlorambucil; D017239:Paclitaxel