Environmental control of immunological synapse formation and duration.
The coordination of T-cell migration and antigen recognition is crucial for an effective immune response. We have proposed that this coordination is achieved by formation of an immunological synapse between the T cell and the antigen-presenting cell (APC). Our view contrasts with the serial encounter model also proposed in this issue of Trends in Immunology, which is based on transient T cell-APC interactions when surrounded by collagen. Here, we propose a model that reconciles immunological synapse formation and serial encounters based on environmental control of immunological synapse formation.
Center for Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St Louis, MO 63110, USA. dustin@saturn.med.nyu.edu
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D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D002465:Cell Movement / Q000502:physiology; D018925:Chemokines / Q000276:immunology; D003094:Collagen / Q000276:immunology*; D005109:Extracellular Matrix / Q000276:immunology*; D008198:Lymph Nodes / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D013997:Time Factors
D018925:Chemokines; D011948:Receptors, Antigen, T-Cell; D003094:Collagen