[Secondary effects of vaccinations].
The adverse effects of vaccines include local reactions and systemic symptoms or illnesses. Local reactions are frequent, most often presenting as transient pain, redness, edema and/or nodule. Fever of short duration is the main systemic symptom, generally occurring within 24-48 hours following vaccination. Some vaccines have recognized specific adverse effects such as thrombocytopenic purpura for the measles-mumps-rubella vaccine, and febrile convulsions for the pertussis vaccine. Hepatitis B vaccine and Haemophilus influenzae type b vaccine have been respectively suspected to be responsible for neurological demyelinating disease and insulin-dependent diabetes mellitus, but large-scale epidemiological studies have failed to confirm these allegations.
Service de pédiatrie, centre hospitalier intercommunal de Créteil, 40, avenue de Verdun, 94000 Créteil, France. Philippe.ovetchkine@chicreteil.fr
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D016907:Adverse Drug Reaction Reporting Systems; D000075202:Contraindications; D003711:Demyelinating Diseases / Q000453:epidemiology / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000453:epidemiology / Q000209:etiology; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000209:etiology; D004890:Erythema / Q000453:epidemiology / Q000209:etiology; D005602:France / Q000453:epidemiology; D006801:Humans; D010146:Pain / Q000453:epidemiology / Q000209:etiology; D011159:Population Surveillance; D011696:Purpura, Thrombocytopenic / Q000453:epidemiology / Q000209:etiology; D006113:United Kingdom / Q000453:epidemiology; D014481:United States / Q000453:epidemiology; D014611:Vaccination / Q000009:adverse effects*