Effects of testosterone and clomiphene on spectral EEG and visual evoked response in a young man with posttraumatic epilepsy.
The effects of testosterone and clomiphene on epilepsy was studied in a young man with posttraumatic seizures. In the control period, digital EEG and visual evoked potentials (VEPs) were recorded under carbamazapine therapy. After testosterone (T), seizures lessened and almost disappeared; the theta, delta, alpha, and beta powers decreased; VEPs increased. After clomiphene, VEPs considerably increased in size; clinical picture slightly improved; EEG power spectrum remained unchanged. It was suggested that T may be beneficial for epilepsy treatment by suppressing the EEG synchronization (slow wave activity) and attenuating the entropy state of the epileptic brain.
Department of Neurology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.
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D000293:Adolescent; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004834:Epilepsy, Post-Traumatic / Q000188:drug therapy*; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D008297:Male; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D016896:Treatment Outcome
D004965:Estrogen Antagonists; D002996:Clomiphene; D013739:Testosterone