[The role of the bcl-2 gene in programmed death of neurons].
Alterations in counterbalance between proliferation and cell death contribute to the pathogenesis of many neurological disorders. The main form of cell death that occurs in the developing nervous system and in many pathological states is apoptosis. Many factors participate in the regulation of programmed cell death. Bcl-2 gene family members modulate the sensitivity of cells to death. Some of them promote cell death and the others, such as bcl-2, prevent apoptosis. Bcl-2 shows a wide expression in the nervous system and protects neurons from various toxic insults. This review focuses on the role of bcl-2 in the apoptosis occurring in some neurological diseases. Understanding of apoptotic threshold may lead to new strategies for the treatment in neurology.
Wolwender
K
K
I Katedry i Kliniki Neurologii Slaskiej Akademii Medycznej w Katowicach.
Lewin-Kowalik
J
J
Larysz-Brysz
M
M
Wolwender
A
A
D016923:Cell Death / Q000502:physiology*; D019254:Genes, bcl-2 / Q000502:physiology*; D006801:Humans; D009422:Nervous System Diseases / Q000235:genetics; D009474:Neurons / Q000502:physiology*