Isolation and characterization of cDNAs for the protein kinase HIPK2.
HIPK2 (homeodomain-interacting protein kinase 2) is a CD95 binding partner in yeast. Its primary amino acid sequence is highly conserved between human and mouse. The highest HIPK2 mRNA expression is found in neuronal tissue. The HIPK2 gene is located on human chromosome 7q33-35 and the protein is mainly localized in the nucleus. HIPK2 has been described to play a role as a co-repressor for homeodomain transcription factors.
Wang
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Universitäts-Kinderklinik Ulm, Forschungslabore, Prittwitzstrasse 43, D-89175 Ulm, Germany.
Hofmann
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Runkel
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Haaf
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Schaller
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Debatin
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Hug
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002897:Chromosomes, Human, Pair 7; D018387:Codon, Initiator; D018076:DNA, Complementary; D005260:Female; D015870:Gene Expression; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger; D017386:Sequence Homology, Amino Acid; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured; D019014:fas Receptor / Q000378:metabolism*
D002352:Carrier Proteins; D018387:Codon, Initiator; D018076:DNA, Complementary; D009687:Nuclear Proteins; D012333:RNA, Messenger; D019014:fas Receptor; C115114:HIPK2 protein, human; C492003:Hipk2 protein, mouse; D017346:Protein Serine-Threonine Kinases