Genetic linkage of childhood atopic dermatitis to psoriasis susceptibility loci.
We have carried out a genome screen for atopic dermatitis (AD) and have identified linkage to AD on chromosomes 1q21, 17q25 and 20p. These regions correspond closely with known psoriasis loci, as does a previously identified AD locus on chromosome 3q21. The results indicate that AD is influenced by genes with general effects on dermal inflammation and immunity.
Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. william.cookson@ndm.ox.ac.uk
W O
WO
Cookson
B
B
Ubhi
R
R
Lawrence
G R
GR
Abecasis
A J
AJ
Walley
H E
HE
Cox
R
R
Coleman
N I
NI
Leaves
R C
RC
Trembath
M F
MF
Moffatt
J I
JI
Harper
D002648:Child; D003876:Dermatitis, Atopic / Q000235:genetics*; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D011565:Psoriasis / Q000235:genetics*