Differential neuropsychological patterns of frontal- and temporal-lobe dysfunction in patients with schizophrenia.
The frontal and temporal lobes have been implicated as pathogenic sites for schizophrenia, although there is a marked heterogeneity of brain function and structure between individual patients. It is currently unclear whether some patients with schizophrenia exhibit primarily frontal lobe dysfunction, while others exhibit primarily temporal-lobe dysfunction. The current investigation examined this issue in a preliminary way by using neurocognitive tests to discriminate test performances of patients with schizophrenia from patients without schizophrenia who had definitive neurological evidence of either frontal- or temporal-lobe dysfunction. Of the patients with schizophrenia, 20.7% were classified as having a frontal lobe dysfunction profile, while 19.3% had a temporal lobe dysfunction profile. Results further clarify neurobiological heterogeneity in schizophrenia by demonstrating that a substantial number of patients with schizophrenia exhibit either primarily frontal- or temporal-lobe dysfunction. Results may partially explain the inadequacy of neurobiological models for schizophrenia that do not consider these differential patterns of dysfunction.
University of Nevada, Las Vegas, NV, USA.
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Allen
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G
Goldstein
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C
Weiner
D000328:Adult; D000704:Analysis of Variance; D001927:Brain Diseases / Q000473:pathology / Q000523:psychology*; D016022:Case-Control Studies; D003072:Cognition Disorders / Q000473:pathology / Q000523:psychology*; D016002:Discriminant Analysis; D005625:Frontal Lobe / Q000473:pathology; D006801:Humans; D008297:Male; D008959:Models, Neurological; D009483:Neuropsychological Tests; D012559:Schizophrenia / Q000150:complications* / Q000473:pathology; D013702:Temporal Lobe / Q000473:pathology