Simultaneous blockade of B7-CD28 and CD40-CD40L costimulation eliminates the direct xenorestricted human anti-porcine T-cell response.
Department of Surgery, The University of Pennsylvania Health System, Philadelphia, Pennsylvania, USA.
S H
SH
Popma
A M
AM
Krasinskas
D
D
Kreisel
W
W
Szeto
A D
AD
McLean
J S
JS
Moore
B R
BR
Rosengard
D000069594:Abatacept; D000818:Animals; D000910:Antibodies, Heterophile / Q000276:immunology*; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000276:immunology*; D018122:B7-1 Antigen / Q000276:immunology*; D018106:CD28 Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D019013:CD40 Antigens / Q000276:immunology*; D023201:CD40 Ligand / Q000276:immunology*; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D060908:CTLA-4 Antigen; D005434:Flow Cytometry; D006801:Humans; D018796:Immunoconjugates; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D013552:Swine; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014183:Transplantation, Heterologous / Q000276:immunology*
D000910:Antibodies, Heterophile; D015703:Antigens, CD; D000943:Antigens, Differentiation; D018122:B7-1 Antigen; D018106:CD28 Antigens; D019013:CD40 Antigens; D060908:CTLA-4 Antigen; C556706:CTLA4 protein, human; D018796:Immunoconjugates; D023201:CD40 Ligand; D000069594:Abatacept