[Activity of chymotrypsin-like proteinases in patients with ischemic heart disease, arterial hypertension and nonspecific aortic arteritis].
OBJECTIVE
To analyze activity of chymotrypsin-like plasma proteinases (CTP) in patients with various cardiovascular diseases.


METHODS
CTP activity was studied in 82 patients with various cardiovascular diseases: 13 coronary heart disease patients with normal arterial pressure, 49 patients with essential hypertension (EH) and secondary arterial hypertension, 20 patients with nonspecific aortic arteritis. 28 donors served control.


RESULTS
CTP activity in plasma of patients with EH rose 4 times compared to donors. If EH patients had concurrent diseases (CHD, chronic pyelonephritis, atherosclerosis of extracranial arteries), CTP activity may increase by 30-300%. In patients with nonspecific aortic arteritis CTP activity in blood plasma is 17.5 times higher than in donors.


CONCLUSIONS
High CTP activity in cardiovascular patients may be explained by chymase and cathepsin G release into blood flow indicating activation of alternative to ACE pathway of angiotensin II production or the presence of the inflammatory process.
Arabidze
G G
GG
Belova
L A
LA
Chikhladze
N M
NM
Shapkina
L S
LS
Ogorodnikova
O G
OG
Kukharchuk
V V
VV
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D056649:Cathepsin G; D002403:Cathepsins / Q000097:blood*; D053818:Chymases; D005260:Female; D013700:Giant Cell Arteritis / Q000201:enzymology*; D006801:Humans; D006973:Hypertension / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000201:enzymology*; D012697:Serine Endopeptidases / Q000097:blood*; D012720:Severity of Illness Index
D015415:Biomarkers; D002403:Cathepsins; D012697:Serine Endopeptidases; C534094:CTSG protein, human; D056649:Cathepsin G; D053818:Chymases