Anticonvulsant properties of N-salicyloyltryptamine in mice.
A new tryptamine analogue, N-salicyloyltryptamine (STP), a potential central nervous system (CNS) depressant, was tested in the pentylenetetrazol (PTZ) and maximal electroshock (MES) models of epilepsy in mice. When administered concurrently, STP (100 mg/kg ip) significantly reduced the number of animals that exhibited PTZ-induced seizures and eliminated the extensor reflex of maximal electric-induced seizures test in 50% of the experimental animals. In addition, it showed protection in the PTZ test by diminishing the death rate.
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Caixa Postal 5009, CEP 58051-970, PB, João Pessoa, Brazil.
F A
FA
Oliveira
R N
RN
de Almeida
M F
MF
Sousa
J M
JM
Barbosa-Filho
S A
SA
Diniz
I A
IA
de Medeiros
D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000627:therapeutic use*; D003292:Convulsants; D004353:Drug Evaluation, Preclinical; D004597:Electroshock; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D014363:Tryptamines / Q000737:chemistry / Q000627:therapeutic use*
D000927:Anticonvulsants; D003292:Convulsants; D014363:Tryptamines; C030820:tryptamine; D010433:Pentylenetetrazole