Invasion-specific genes in malignancy: serial analysis of gene expression comparisons of primary and passaged cancers.
The invasive growth of malignant cells induces an admixture of host reactions including desmoplasia, angiogenesis, and immune reactions Pancreatic cancer has a prominent and characteristic host reaction at the site of primary invasion. To obtain new insights into the process of tumor invasion, we studied global patterns of gene expression using serial analysis of gene expression in pancreatic cancer, with extension to other tumor types. Here we report a cluster of invasion-specific genes in pancreatic and other cancers. This cluster contains genes that derive from distinct components of the host reaction, including some that may be useful as diagnostic markers and therapeutic targets.
Department of Oncology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21231, USA.
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B
Ryu
J
J
Jones
M A
MA
Hollingsworth
R H
RH
Hruban
S E
SE
Kern
D016000:Cluster Analysis; D005544:Forecasting; D020869:Gene Expression Profiling; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009369:Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000235:genetics; D010190:Pancreatic Neoplasms / Q000098:blood supply / Q000235:genetics / Q000473:pathology
D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains