Total synthesis of FR901483.
[structure: see text]. The total synthesis of FR901483, a structurally novel immunosuppressant, has been accomplished by the use of technology recently developed in this laboratory for the oxidative cyclization of phenolic oxazolines to spirolactams. Our approach may reflect the biosynthetic pathway leading to the natural product.
Ousmer
M
M
Laboratoire de Synthèse et Méthodologie Organiques, Université Claude Bernard Lyon 1 and Ecole Supérieure de Chimie, Physique, Electronique de Lyon, 43, Bd. du 11 Novembre 1918, 69622 Villeurbanne Cedex, France.
Braun
N A
NA
Ciufolini
M A
MA
D003500:Cyclization; D005658:Fungi / Q000737:chemistry; D007166:Immunosuppressive Agents / Q000138:chemical synthesis*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D010084:Oxidation-Reduction
C098358:FR 901483; D007166:Immunosuppressive Agents; D009943:Organophosphorus Compounds