Lower body adynamia as a factor to reduce the risk of hypobaric decompression sickness.
BACKGROUND
We define lower body adynamia (LBA) as restricted lower body movement, particularly walking, during both the denitrogenation phase at site pressure and during the exercise phase while at altitude.


OBJECTIVE
Our null hypothesis is that subjects who are adynamic in the lower body but do upper body exercise will be at similar risk of decompression sickness (DCS) and venous gas emboli (VGE) as subjects who randomly walk but do no planned exercise while at altitude.


METHODS
We selected a data set that contained 1401 altitude exposures with the following conditions: a) walking was part of the exercise at altitude; or b) there was no planned exercise done at altitude but walking was not restricted; or c) LBA was inforced, but upper body exercise was done at altitude. We used logistic regression (LR) on all 1401 exposures, a log logistic survival analysis (SA) on a subset of data from "a" and "c" (n = 234), and estimated a model for how the incidence of VGE changes through time.


RESULTS
The estimated probabilities of DCS and VGE with 95% confidence intervals (Cls) from the LR with a simulation of a 3-h oxygen prebreathe, a 4-h exposure to 4.3 psia in a male, and exercise and LBA conditions as described above are: (see text).


CONCLUSIONS
LBA that includes upper body exercise appears to be as protective against DCS and VGE as random walking by subjects who did no prescribed exercise while at altitude, and is more protective than exercise that included walking. Our conclusions are based on an assumption that we have adequately controlled, through our data selection process and the use of multivariable models, important variables in tests that were not done at the Johnson Space Center.
Life Sciences Research Laboratories, NASA-Johnson Space Center, Houston, TX, USA. jconkin@ems.jsc.nasa.gov
J
J
Conkin
M R
MR
Powell
D002306:Cardiac Volume / Q000502:physiology; D002319:Cardiovascular System / Q000503:physiopathology*; D002463:Cell Membrane Permeability / Q000502:physiology; D016001:Confidence Intervals; D003665:Decompression Sickness / Q000209:etiology / Q000517:prevention & control*; D004618:Embolism, Air / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008150:Lower Body Negative Pressure; D008297:Male; D008954:Models, Biological; D009584:Nitrogen / Q000378:metabolism; D016017:Odds Ratio; D016019:Survival Analysis
D009584:Nitrogen