Effect of the antimalarial drug halofantrine in the long QT syndrome due to a mutation of the cardiac sodium channel gene SCN5A.
Piippo
K
K
Department of Medicine, Helsinki University Hospital, Helsinki, Finland.
Holmström
S
S
Swan
H
H
Viitasalo
M
M
Raatikka
M
M
Toivonen
L
L
Kontula
K
K
D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D000962:Antimalarials / Q000009:adverse effects*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000235:genetics*; D008297:Male; D008969:Molecular Sequence Data; D009154:Mutation; D062554:NAV1.5 Voltage-Gated Sodium Channel; D010375:Pedigree; D010616:Phenanthrenes / Q000009:adverse effects*; D015222:Sodium Channels / Q000235:genetics*; D017180:Tachycardia, Ventricular / Q000139:chemically induced*
D000962:Antimalarials; D062554:NAV1.5 Voltage-Gated Sodium Channel; D010616:Phenanthrenes; C568320:SCN5A protein, human; D015222:Sodium Channels; C023768:halofantrine