The role of cardiac troponin I in determining the necessity for exercise electrocardiography in low risk patients with chest pain.
BACKGROUND
Assessment of non-cardiac chest pain places a considerable burden on healthcare resources. The current practice of serial electrocardiographs (ECGs), serum creatinine phosphokinase and by pre-discharge exercise electrocardiography gives an average in-hospital stay of 3.7 days.


OBJECTIVE
This study assess the use of a sensitive assay for cardiac troponin I (cTnI) to identify a low risk group for whom exercise ECG may not be indicated.


METHODS
Ninety-five patients with acute chest pain and with peak cTnI < 0.1 ng/ml and a non-diagnostic resting ECG were studied. Patients were divided into two groups. Group one had normal range cTnI (< 0.03 ng/ml). Group two had minimal elevation of cTnI (0.03-0.099 ng/ml). Average follow-up was 172 days.


RESULTS
Nineteen patients had minimal elevation in cTnI of whom five developed significant ST shift on exercise and five had adverse events. No patient with a normal range cTnI had a positive stress test and none suffered an adverse event (p < 0.001).


CONCLUSIONS
CTnI in the normal range can identify patients with acute chest pain who have a negligible event rate and for whom exercise electrocardiography is not required.
Fleming
S M
SM
Department of Cardiology, University College Hospital Galway, Ireland.
Divilly
M
M
Chakravarthi
P I
PI
Grimes
H
H
Daly
K
K
D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology*; D003327:Coronary Disease / Q000175:diagnosis*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D018570:Risk Assessment; D019210:Troponin I / Q000097:blood*
D019210:Troponin I