Interaction of T cells with APCs: the serial encounter model.
Primary immune responses are initiated by specific physical interaction of antigen-specific T cells and professional antigen-presenting cells (APCs). Productive interactions can be a dynamic process that combines physical T-cell binding to APCs with vigorous crawling across and scanning of the APC surface, resulting in signal induction. After T-cell detachment, subsequent migratory contacts to the same or neighboring dendritic cells (DCs) allow the accumulation of sequential signals and interaction time. Here, we develop a serial encounter model of T-cell activation and discuss how the summation of multiple signals provides an efficient strategy to control an ongoing immune response.
Cell Migration Laboratory, Dept of Dermatology, University of Würzburg, Josef-Schneider-Str. 2, 97080 Würzburg, Germany. peter.fr@mail.uni-wuerzburg.de
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Friedl
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Gunzer
D017951:Antigen Presentation / Q000276:immunology; D000938:Antigen-Presenting Cells / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*