Beneficial effect of combination therapy with ozagrel and pranlukast in exercise-induced asthma demonstrated by krypton-81 m ventilation scintigraphy--a case report.
BACKGROUND
We evaluated the effect of combination therapy with thromboxane A2 synthesis inhibitor and leukotriene receptor antagonist in a patient with exercise-induced asthma using krypton-81 m ventilation scintigraphy.


METHODS
In a patient with exercise-induced asthma, we found exercise-induced abnormalities of respiratory function test and ventilation scintigraphy, and increases in plasma concentrations of thromboxane B2 and leukotriene C4 with exercise.


METHODS
A thromboxane A2 synthesis inhibitor (ozagrel) and a leukotriene receptor antagonist (pranlukast) were prescribed.


RESULTS
After treatment for 2 weeks, abnormalities of respiratory function test and ventilation scintigraphy improved.


CONCLUSIONS
The combination therapy with ozagrel and pranlukast might be useful for the relief of symptoms in patients with exercise-induced asthma, and krypton-81 m ventilation scintigraphy could be a useful tool for visible evaluation of treatment.
4th Department of Internal Medicine, Shimane Medical University, Izumo City, Shimane, Japan.
N
N
Takahashi
Y
Y
Ishibashi
Y
Y
Murakami
H
H
Shimizu
Y
Y
Ohta
T
T
Asanuma
H
H
Katoh
K
K
Sano
T
T
Shimada
D001250:Asthma, Exercise-Induced / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D002867:Chromones / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007727:Krypton Radioisotopes; D020024:Leukotriene Antagonists / Q000008:administration & dosage*; D008689:Methacrylates / Q000008:administration & dosage*; D008875:Middle Aged; D011877:Radionuclide Imaging; D012129:Respiratory Function Tests; D012720:Severity of Illness Index; D016896:Treatment Outcome
D002867:Chromones; D004791:Enzyme Inhibitors; D007727:Krypton Radioisotopes; D020024:Leukotriene Antagonists; D008689:Methacrylates; C034364:ozagrel; C047681:pranlukast