The Ras pathway and spindle assembly collide?
Although alterations in Ras signalling are found in about 30% of human cancers, the transforming activity of oncogenic Ras is not fully understood. In a recent paper, a putative Ras1 effector in S. pombe, named Scd1, was reported to localize to mitotic spindles. Scd1 physically associates with Moe1, a factor that may contribute to the inherent instability of microtubules (MTs) and appears to be needed for proper spindle function. Altered MT dynamics within the spindle are likely to affect spindle assembly and chromosome capture, processes that need to be delicately controlled if cells are to guard against genome instability and transformation. BioEssays 23:307-310, 2001.
Segal
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The Scripps Research Institute, La Jolla, CA 92037, USA.
Clarke
D J
DJ
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism / Q000502:physiology; D018797:Cell Cycle Proteins / Q000378:metabolism / Q000502:physiology; D039642:Eukaryotic Initiation Factors; D005656:Fungal Proteins / Q000378:metabolism / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology; D020662:Guanine Nucleotide Exchange Factors; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000378:metabolism / Q000502:physiology; D016283:Proto-Oncogene Proteins p21(ras) / Q000378:metabolism / Q000502:physiology*; D012568:Schizosaccharomyces / Q000378:metabolism / Q000502:physiology; D029702:Schizosaccharomyces pombe Proteins; D015398:Signal Transduction / Q000502:physiology*; D008941:Spindle Apparatus / Q000502:physiology*; D018631:ras Proteins
D002352:Carrier Proteins; D018797:Cell Cycle Proteins; D039642:Eukaryotic Initiation Factors; D005656:Fungal Proteins; D020662:Guanine Nucleotide Exchange Factors; C117671:Moe1 protein, S pombe; D011518:Proto-Oncogene Proteins; D029702:Schizosaccharomyces pombe Proteins; C089769:scd1 protein, S pombe; D019204:GTP-Binding Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras); C492657:Ras1 protein, S pombe; D018631:ras Proteins