Defective glucose-regulated insulin gene expression associated with PDX-1 deficiency in the Psammomys obesus model of type 2 diabetes.
Leibowitz
G
G
Department of Endocrinology and Metabolism, Hebrew University, Hadassah Medical Center, Jerusalem, Israel. gleib@hadassah.org.il
Melloul
D
D
Yuli
M
M
Gross
D J
DJ
Apelqvist
A
A
Edlund
H
H
Cerasi
E
E
Kaiser
N
N
D000818:Animals; D002454:Cell Differentiation; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D004195:Disease Models, Animal; D005786:Gene Expression Regulation / Q000187:drug effects; D005849:Gerbillinae; D005947:Glucose / Q000494:pharmacology*; D018398:Homeodomain Proteins; D006801:Humans; D006943:Hyperglycemia / Q000235:genetics; D007328:Insulin / Q000235:genetics* / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism; D012333:RNA, Messenger / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D051381:Rats; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015534:Trans-Activators / Q000172:deficiency / Q000235:genetics*
D018398:Homeodomain Proteins; D007328:Insulin; D012333:RNA, Messenger; D015534:Trans-Activators; C084010:pancreatic and duodenal homeobox 1 protein; D005947:Glucose