Interactions of some organic solvents: hydrocarbons and chloroalkene.
Metabolic and toxicodynamic interactions of some organic solvents in rats repeatedly treated with medium dose levels were examined. It was shown that both n-hexane and ethylbenzene significantly inhibited tetrachloroethylene metabolism during a 2-week period. n-Hexane and tetrachloroethylene enhanced metabolism of ethylbenzene whereas ethylbenzene suppressed n-hexane metabolism only at the end of the experiment. Biochemical changes, especially the drop in the level of non-protein sulfhydryl groups in tissues of rats treated with organic solvent mixtures, were significantly less pronounced than those observed after these chemicals were administered separately. These results demonstrate that metabolic interactions between hydrocarbons and chloroalkene may lead to a modification of the biological response to these compounds.
Central Institute for Labour Protection, Department of Chemical and Aerosol Hazards, Czerniakowska 16, 00-701 Warsaw, Poland. josko@ciop.pl
J
J
Skowroń
K
K
Miranowicz-Dzierzawska
L
L
Zapór
M
M
Gołofit-Szymczak
A
A
Starek
D000818:Animals; D001555:Benzene Derivatives / Q000378:metabolism* / Q000633:toxicity; D006586:Hexanes / Q000378:metabolism* / Q000633:toxicity; D008297:Male; D011044:Poland; D051381:Rats; D017208:Rats, Wistar; D012997:Solvents / Q000633:toxicity*; D013750:Tetrachloroethylene / Q000378:metabolism* / Q000633:toxicity
D001555:Benzene Derivatives; D006586:Hexanes; D012997:Solvents; C026385:n-hexane; C004912:ethylbenzene; D013750:Tetrachloroethylene