Synthesis of substituted imidazopyrazines as ligands for the human somatostatin receptor subtype 5.
A new preparation of trisubstituted imidazopyrazines and dihydroimidazopyrazines via parallel synthesis using aminoacids and bromoketones resulted in the discovery of non-peptidic sst5 selective agonists.
Institut Henri Beaufour, Les Ulis, France. m-odile.galcera.contour@beaufour-ipsen.com
M O
MO
Contour-Galéra
L
L
Poitout
C
C
Moinet
B
B
Morgan
T
T
Gordon
P
P
Roubert
C
C
Thurieau
D000818:Animals; D016466:CHO Cells; D020650:Combinatorial Chemistry Techniques; D006224:Cricetinae; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D008024:Ligands; D015394:Molecular Structure; D011485:Protein Binding; D020033:Protein Isoforms / Q000378:metabolism; D011719:Pyrazines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D017481:Receptors, Somatostatin / Q000819:agonists / Q000737:chemistry / Q000378:metabolism*
D007093:Imidazoles; D008024:Ligands; D020033:Protein Isoforms; D011719:Pyrazines; D017481:Receptors, Somatostatin; C094573:somatostatin receptor 5