[Fatty acids of plasma and erythrocyte phospholipids in malnourished infants well-fed by breast feeding or formula].
Polyunsaturated fatty acids (PUFA) derived from essential fatty acids (EFA) play an important role in prenatal visual and neural development. Protein-energy malnutrition affects PUFA supply, and hence the synthesis of structural lipids during growth. Recently, some physiological studies reported abnormalities in the neurological functions of formula-fed infants relative to breast-fed. The purpose of our study was to assess whether fatty acid composition of the malnourished infant diet modifies plasma and erythrocyte phospholipid fatty acid composition. Three groups of full-term malnourished infants were selected according to their prior feeding. Two groups had received commercial formulas, one of them supplied with linoleic and alpha-linolenic acid, and the other supplied in addition with long chain PUFA from n-3 and n-6 series. The reference group of breast-fed infants was also enrolled. Plasma and erythrocyte phospholipid fatty acid composition was determined by gas-liquid chromatography. Those infants receiving formulas showed in plasma and erythrocyte phospholipids increased values in total saturated and monoethylenic fatty acids, and decreased values in polyunsaturated fatty acids from both n-6 and n-3 series, relative to that of breast-fed infants. These differences were more remarkable in the case of infants who received formula without PUFA. We conclude that in malnourished infants, a nutrient formula enriched with long chain fatty acids of n-6 and n-3 series could be helpful to achieve an erythrocyte and plasma fatty acid pattern similar to that obtained in breast-fed infants.
Marin
M C
MC
Instituto de Investigaciones Bioquímicas de La Plata (INIBIOLP), Facultad de Ciencias Médicas, Universidad Nacional de La Plata, Argentina. mmarin@atlas.med.unlp.edu.ar
Rey
G E
GE
Rodrigo
M A
MA
de Alaniz
M J
MJ
D001942:Breast Feeding; D016022:Case-Control Studies; D004912:Erythrocytes / Q000737:chemistry*; D005227:Fatty Acids / Q000032:analysis*; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D007225:Infant Food; D007228:Infant Nutrition Disorders / Q000378:metabolism*; D008297:Male; D010743:Phospholipids / Q000097:blood / Q000737:chemistry*; D011502:Protein-Energy Malnutrition / Q000378:metabolism
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D010743:Phospholipids