Toxicity studies of Rhizoma Polygonati Odorati.
The toxicity of the water-soluble extract of Rhizoma Polygonati Odorati was studied in the present investigation, which included its acute toxicity, chronic toxicity, and genetic toxicity. The aqueous extract of Rhizoma Polygonati Odorati did not cause seriously abnormal signs or death to animals in the acute toxicity test and in the 6-month chronic toxicity test. Neither was genetic toxicity found in the Ames test, the micronucleus test of bone marrow and the sperm malformation test in mice.
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences, Beijing 100094, People's Republic of China. chenhb@emirates.net.ae
H
H
Chen
R
R
Feng
Y
Y
Guo
L
L
Sun
Y
Y
Zhou
J
J
Jiang
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000633:toxicity*; D005260:Female; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D008517:Phytotherapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013094:Spermatozoa / Q000187:drug effects
D004365:Drugs, Chinese Herbal