The predictive power of haplotypes in clinical response.
A variety of approaches have been proposed to find genetic markers that can be used in a clinical setting. Single nucleotide polymorphisms (SNPs) are the basis of the most commonly used approaches. Here we describe an approach using gene-based haplotypes, which are collections of SNPs located throughout the ftinctional regions of candidate genes, and organised as they occur separately on an individual's two chromosomes. The main point of this review is that the haplotype has greater power than any individual SNP to track an unobsenrved, but evolutionarily linked, variable site.
Judson
R
R
Genaissance Pharmaceuticals, New Haven, CT 06511, USA. r.judson@genaissance.com
Stephens
J C
JC
Windemuth
A
A
D000818:Animals; D004358:Drug Therapy; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D010597:Pharmacogenetics; D011237:Predictive Value of Tests