Malformations of angiogenesis in the low differentiated human carcinomas. immunohistochemical study.
Our previous observations showed that the perivascular mesenchyma of the thin-walled vessels (capillaries) in cancers may be the source of organ-specific stem cells. We suggested that the cells forming vascular channels in altered stroma participate in the tumor development. This study was designed to examine the distribution of the vessels and their appearance in the breast, lung and colon cancers. Using immunohistochemical methods, we have shown that in the low differentiated tumors both CD31 and factor VIII antigens may be expressed in capillaries chiefly on the periphery of neoplastic foci. Many of these vessels were discontinuous, with interruptions or unformed tubules. Sporadically, CD31 protein and factor VIII antigens were not expressed in capillaries inside the very low differentiated cancer cases. It is difficult to assess by immunohistochemical means whether the vascular malformations are the primary or secondary phenomena in the malignancy and why these abnormalities were especially visible in some low differentiated cancers.
Department of Immunopathology, Medical University of Gdańsk, Poland. blew@amedec.amg.gda.pl
A
A
Zółtowska
J
J
St piński
B
B
Lewko
B
B
Zamorska
A
A
Roszkiewicz
K
K
Serkies
W J
WJ
Kruszewski
D001943:Breast Neoplasms / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000098:blood supply / Q000276:immunology / Q000473:pathology; D008207:Lymphatic Metastasis / Q000276:immunology / Q000473:pathology; D009369:Neoplasms / Q000098:blood supply* / Q000276:immunology / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000473:pathology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000378:metabolism
D019408:Platelet Endothelial Cell Adhesion Molecule-1; D005169:Factor VIII