Interferon-alpha-induced pure red cell aplasia following chronic myelogenous leukemia.
We report a case of pure red cell aplasia (PRCA) that resulted from interferon (IFN)-alpha therapy for chronic myelogenous leukemia. PRCA improved within 1 month after IFN-alpha was discontinued. This case indicates the involvement of IFN-alpha in the pathogenesis of PRCA.
Tomita
N
N
Department of Hematology, Fujieda Municipal General Hospital, Shizuoka, Japan. n-tomita@tf6.so-net.ne.jp
Motomura
S
S
Ishigatsubo
Y
Y
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D012010:Red-Cell Aplasia, Pure / Q000139:chemically induced*
D000970:Antineoplastic Agents; D016898:Interferon-alpha