Synthetic applications of epoxide hydrolases.
There have been several recent advances in the area of biocatalysed hydrolytic kinetic resolution of epoxides using 'newly discovered' enzymes (i.e. epoxide hydrolases). These biocatalysts, two of which will become commercially available in the near future, appear to be highly promising tools for fine organic synthesis, as they enable the preparation of various epoxides and/or their corresponding diols in enantiopure form.
Archelas
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Groupe Biocatalyse et Chimie Fine, UMR CNRS 6111, Université de la Méditerranée, Faculté des Sciences de Luminy, Marseille, France. archelas@luminy.univ-mrs.fr
Furstoss
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D001234:Aspergillus niger / Q000201:enzymology* / Q000235:genetics; D018533:Biomass; D001709:Biotechnology / Q000639:trends*; D003001:Cloning, Molecular; D004851:Epoxide Hydrolases / Q000737:chemistry / Q000378:metabolism*; D004852:Epoxy Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D006868:Hydrolysis; D008798:Mevalonic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D016297:Mutagenesis, Site-Directed / Q000235:genetics; D012231:Rhizobium / Q000201:enzymology* / Q000235:genetics; D013237:Stereoisomerism; D013379:Substrate Specificity / Q000502:physiology
D004852:Epoxy Compounds; C015367:mevalonolactone; D004851:Epoxide Hydrolases; D008798:Mevalonic Acid