In vitro and in vivo combinations of cefotaxime and minocycline against Aeromonas hydrophila.
The activities of cefotaxime and minocycline against Aeromonas hydrophila were investigated. Cefotaxime (4 times the MIC) plus minocycline (0.75 times the MIC) elicited an inhibitory effect for 48 h in a time-kill study, and more infected mice treated with both drugs survived (91%) than survived after treatment with cefotaxime (9%) or minocycline (44%) alone, suggesting that cefotaxime and minocycline act synergistically against A. hydrophila.
Ko
W C
WC
Department of Internal Medicine, National Cheng Kung University Hospital, National Cheng Kung University Medical College, Tainan, Taiwan.
Lee
H C
HC
Chuang
Y C
YC
Ten
S H
SH
Su
C Y
CY
Wu
J J
JJ
D016980:Aeromonas hydrophila / Q000187:drug effects*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002439:Cefotaxime / Q000494:pharmacology / Q000627:therapeutic use*; D002511:Cephalosporins / Q000494:pharmacology / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination / Q000494:pharmacology / Q000627:therapeutic use*; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy*; D007700:Kinetics; D051379:Mice; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology / Q000627:therapeutic use*; D016019:Survival Analysis
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D008911:Minocycline; D002439:Cefotaxime