Progress in vaccination against Helicobacter pylori.
This review discusses recent progress in the development of a vaccine against Helicobacter pylori. This progress includes demonstration that: effective immunisation is independent of antibodies but dependent upon CD4+ T helper cells, although their role remains unknown; the immunisation regime can be improved to increase efficacy; successful immunisation against H. pylori is possible using a live vector; a strain of H. pylori suitable for experimental infection of humans has been developed. Important issues that remain to be addressed include incomplete protection, non-availability of suitable mucosal adjuvants and post-immunisation gastritis. Significantly, commercial development of products for clinical trial is underway.
Sutton
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School of Microbiology and Immunology, University of New South Wales, NSW 2052, Sydney, Australia.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000009:adverse effects / Q000302:isolation & purification / Q000494:pharmacology; D005756:Gastritis / Q000209:etiology; D016481:Helicobacter Infections / Q000276:immunology / Q000517:prevention & control*; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D018928:Immunity, Mucosal; D014611:Vaccination / Q000009:adverse effects / Q000639:trends
D000276:Adjuvants, Immunologic; D001428:Bacterial Vaccines