LpAI in HDL subfractions: serum levels in men and women with coronary heart disease and changes under hypolipemic therapy.
BACKGROUND
It is generally accepted that different HDL subpopulations may vary in their antiatherogenic potential, and the identification and differentiation of individual HDL subclasses may be useful in documentation and understanding of metabolic changes of different HDL particle groups.


METHODS
In the present study, LpAI particles concentrations in HDL(2) and HDL(3) subfractions were determined in serum of 54 CHD patients (33 men and 21 women) and 46 control subjects (19 men and 27 women) with similar total cholesterol and HDL-cholesterol levels.


RESULTS
In CHD patients, both men and women, as compared to control subjects lower levels of LpAI subpopulations were found, however, the difference was much more predominant for LpAI-HDL(2) than for LpAI-HDL(3). The effect of hypolipidemic treatment on the distribution of LpAI subpopulations between HDL subfractions was investigated in 44 hyperlipidemic patients assigned to fenofibrate therapy and 43 patients assigned to simvastatin therapy. Fenofibrate did not change LpAI level but had an effect on LpAI particle distribution among HDL(2) and HDL(3) increasing LpAI concentration in HDL(2) and slightly decreasing LpAI concentration in HDL(3). Simvastatin led to an increase in LpAI-HDL(3) and did not change significantly LpAI-HDL(2) particle concentration.


CONCLUSIONS
Further studies are needed to evaluate the significance of different HDL subpopulations.
National Food and Nutrition Institute, Powsinska 61/63, 02-903, Warsaw, Poland.
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Nowicka
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Jarosz
D008076:Cholesterol, HDL / Q000097:blood* / Q000737:chemistry / Q000145:classification; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D017270:Lipoprotein(a) / Q000031:analogs & derivatives / Q000097:blood*; D008297:Male
D008076:Cholesterol, HDL; D000960:Hypolipidemic Agents; D017270:Lipoprotein(a); C078260:lipoprotein A-I