Maelstrom is required to position the MTOC in stage 2-6 Drosophila oocytes.
The factors that determine intracellular polarity are largely unknown. In Drosophila oocytes one of the earliest polar events is the positioning of the microtubule-organizing center (MTOC). Here we present data that are consistent with the hypothesis that maelstrom is required for posterior positioning of the MTOC.
Department of Biochemistry, University of Washington, Seattle 98195, USA.
N J
NJ
Clegg
S D
SD
Findley
A P
AP
Mahowald
H
H
Ruohola-Baker
D000818:Animals; D016764:Cell Polarity; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000502:physiology*; D017930:Genes, Reporter; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism*; D016547:Kinesins; D018613:Microscopy, Confocal; D008868:Microtubule Proteins / Q000378:metabolism; D022101:Microtubule-Organizing Center / Q000378:metabolism*; D008870:Microtubules / Q000378:metabolism; D009865:Oocytes / Q000254:growth & development / Q000502:physiology* / Q000648:ultrastructure; D011993:Recombinant Fusion Proteins / Q000378:metabolism
D029721:Drosophila Proteins; D019476:Insect Proteins; D008868:Microtubule Proteins; D011993:Recombinant Fusion Proteins; C109767:mael protein, Drosophila; C080298:Nod protein, Drosophila; D016547:Kinesins