[Sinus floor augmentation with simultaneous implant insertion using recombinant human osteogenic protein-1].
BACKGROUND
The purpose of this study was to examine whether the combination of an osteoinductive protein (recombinant human osteogenic protein-(rhOP-1 = bone morphogenetic protein-7) with natural bovine bone mineral (BioOss) would improve ossification and the bone-implant contact (BIC) in a sinus floor augmentation with simultaneous placement of implants.


METHODS
In this study, the maxillary sinus floors in five miniature pigs were augmented with 3 ml BioOss containing 420 micrograms rhOP-1 on the test side and 3 ml BioOss alone on the control side. At the time of augmentation a titanium implant (ITI) was inserted from a laterocaudal direction.


RESULTS
After 6 months of healing the sites of augmentation were removed and examined in non-decalcified sections by microradiography, fluorescence microscopy of sequentially labelled specimens and by histometry. On both sides, significant amounts of newly formed bone were observed. However, on the test sites, the BIC in the augmented area was 80.0% versus 38.6% on control sites. It can be concluded that the application of bone morphogenetic proteins caused a more rapid and enhanced osseointegration of simultaneously placed implants when compared to the bone substitute alone.


CONCLUSIONS
Therefore recombinant human osteogenic protein-1 delivered by natural bone mineral has the potential to become a clinical alternative for autogenous bone grafts in sinus floor augmentation.
Terheyden
H
H
Klinik für Mund-, Kiefer-, Gesichtschirurgie, Christian Albrechts Universität zu Kiel.
Jepsen
S
S
Möller
B
B
Rueger
D
D
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D016025:Bone Transplantation; D006801:Humans; D008443:Maxillary Sinus / Q000187:drug effects* / Q000473:pathology; D008903:Minerals / Q000494:pharmacology*; D016348:Osseointegration / Q000187:drug effects*; D019919:Prosthesis Implantation; D011994:Recombinant Proteins / Q000494:pharmacology; D013552:Swine; D013556:Swine, Miniature; D014025:Titanium; D016212:Transforming Growth Factor beta
C525819:BMP7 protein, human; C077540:Bio-Oss; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D008903:Minerals; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta; D014025:Titanium