Synthesis of (+)-cyclozonarone and the absolute configuration of naturally occurring (-)-cyclozonarone.
Synthesis of (+)-cyclozonarone (1) has been achieved using (-)-polygodial (3) as chiral starting material. The absolute configuration of naturally occurring (-)-cyclozonarone was established as 5R,10R by comparison of spectral data and optical rotation with those of (+)-cyclozonarone.
Cortés
M
M
Facultad de Química, Pontificia Universidad Católica de Chile, Casilla 306, Correo 22, Santiago, Chile. mcortesm@puc.cl
Valderrama
J A
JA
Cuellar
M
M
Armstrong
V
V
Preite
M
M
D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D000459:Phaeophyceae / Q000737:chemistry*; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry
D012717:Sesquiterpenes; C429221:cyclozonarone