Novel[1n]-meta-heterophane frameworks with a bis-betaine nature.
A convergent "5 + 1" and "5 + 3" synthetic strategy allowed the synthesis of the first examples of bis-betaines 2 and 3, a prototype of phanes that incorporate heterocyclic betaines. The structure of the quadrupolar macrocyclic systems 2 and 3 together with the dicationic [1(6)]- and [1(8)] meta-heterophane precursors 5*2X and 6*2X were examined by spectroscopy using 1H and 13C NMR techniques together with 1H-DNMR studies and electrospray ionization mass spectrometry.
Laboratori de Química Orgànica, Facultat de Farmàcia, Universitat de Barcelona, 08028-Barcelona, Spain. betaines@farmacia.far.ub.es
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Alcalde
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Ayala
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Dinarès
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Mesquida
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Sánchez-Ferrando