Bleeding complication during coumarin therapy due to amiodarone and azithromycin.
A patient with mechanical heart valves developed bleeding, after the introduction of amiodarone and azithromycin. Though the anticoagulant effect could be neutralized, the patient succumbed to heart failure. Any new drug prescribed to patients on anticoagulant must be assessed for its potential for interaction and warrants frequent prothrombin time testing.
Bharat
V
V
Department of Cardiology, Tata Main Hospital, Jamshedpur, Bihar, 831 001.
Mohanty
B
B
D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects*; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001281:Atrial Fibrillation / Q000188:drug therapy; D017963:Azithromycin / Q000008:administration & dosage / Q000009:adverse effects*; D003374:Coumarins / Q000008:administration & dosage / Q000009:adverse effects*; D004347:Drug Interactions; D017809:Fatal Outcome; D005260:Female; D019918:Heart Valve Prosthesis Implantation; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D012141:Respiratory Tract Infections / Q000188:drug therapy
D000925:Anticoagulants; D003374:Coumarins; D017963:Azithromycin; C030123:coumarin; D000638:Amiodarone