Altered neuroadaptation in opiate dependence and neurogenic inflammatory nociception in alpha CGRP-deficient mice.
The neuropeptide alpha CGRP (calcitonin gene-related peptide) is involved in the complex process of pain signaling, but the precise contribution of alpha CGRP remains unclear. Here we show that mice lacking alpha CGRP display an attenuated response to chemical pain and inflammation. Furthermore, alpha CGRP(-/-) mice do not show changes in heroin self-administration or morphine tolerance, but display a marked decrease in morphine withdrawal signs, suggesting an important contribution of alpha CGRP to opiate withdrawal.
CNRS URA 2182, Neurobiologie Moléculaire, Institut Pasteur, 25 rue du Docteur Roux, 75724 Paris Cedex 15, France.
A M
AM
Salmon
M I
MI
Damaj
L M
LM
Marubio
M P
MP
Epping-Jordan
E
E
Merlo-Pich
J P
JP
Changeux
D019342:Acetic Acid / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000235:genetics / Q000378:metabolism*; D002211:Capsaicin / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D005404:Fixatives / Q000494:pharmacology; D005557:Formaldehyde / Q000494:pharmacology; D005731:Ganglionic Stimulants / Q000494:pharmacology; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D008278:Magnesium Sulfate / Q000494:pharmacology; D051379:Mice; D008822:Mice, Transgenic; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology; D009293:Opioid-Related Disorders / Q000503:physiopathology*; D010146:Pain / Q000139:chemically induced / Q000503:physiopathology*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D000701:Analgesics, Opioid; D005404:Fixatives; D005731:Ganglionic Stimulants; D009292:Narcotic Antagonists; D005557:Formaldehyde; D009270:Naloxone; D009538:Nicotine; D008278:Magnesium Sulfate; D009020:Morphine; D002351:Carrageenan; D015740:Calcitonin Gene-Related Peptide; D019342:Acetic Acid; D002211:Capsaicin