[Effects of conjugated linoleic acid on the metastasis of mouse melanoma B16-MB].
In order to explore the effects of conjugated linoleic acid on tumor metastasis, the proliferation, gap junction intercellular communication (GJIC), adhesion to extracellular matrix, and metastasis cascades of tumor cells were imitated in cell culture. The results showed that 100 and 200 mumol/L conjugated linoleic acid could inhibit the proliferation and the adhesion of tumor cells to extracellular matrix, and could recover its gap junction intercellulor communication.
Public Health School of Harbin Medical University, Harbin 150001, China.
Y
Y
Xue
B
B
Chen
Y
Y
Zheng
L
L
Yuan
D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D019787:Linoleic Acid / Q000494:pharmacology*; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D009362:Neoplasm Metastasis / Q000517:prevention & control; D014407:Tumor Cells, Cultured
D016588:Anticarcinogenic Agents; D019787:Linoleic Acid