Antihypertensive and vasorelaxant effects of aqueous extract from Croton schiedeanus Schlecht in rats.
Antihypertensive and vasorelaxant effects of treatment with the aqueous extract of Croton schiedeanus Schlecht (AECS) were investigated in anaesthetized spontaneously hypertensive rats (SHR). Intravenous bolus injections of AECS (5-100 mg/kg) elicited dose-dependent decreases in mean arterial pressure (MAP) and heart rate (HR). Additionally, AECS (10(-6)-3x10(-3)g/ml) completely relaxed the contractions induced by high K(+) concentrations in intact rat aortic rings in a concentration-dependent manner.
Laboratorio de Farmacognosia y Farmacología, Departamento de Fisiología y Farmacología, Facultad de Farmacia, Universidad de Salamanca, E-37007, Salamanca, Spain.
M F
MF
Guerrero
R
R
Carrón
M L
ML
Martín
L
L
San Román
M T
MT
Reguero
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D019665:Euphorbiaceae / Q000737:chemistry*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D014665:Vasodilator Agents / Q000494:pharmacology*
D000959:Antihypertensive Agents; D010936:Plant Extracts; D014665:Vasodilator Agents