Low-dose heparin: a novel approach in immunosuppression.
Very low subcutaneous doses of standard and low molecular weight heparin inhibited the traffic of sensitized lymphocytes to a graft site, reduced in situ mononuclear cell infiltration and prolonged skin allograft survival in mice. Similar effects were caused by low doses of oral heparin, while higher oral doses prolonged graft survival. Our results suggest that oral heparin may have immunosuppressive properties applicable in clinical transplantation.
Górski
A
A
Department of Immunology, Transplantation Institute, Warsaw Medical School, Poland.
Makula
J
J
Morzycka-Michalik
M
M
Lao
M
M
Gradowska
L
L
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006085:Graft Survival / Q000187:drug effects* / Q000502:physiology; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D007165:Immunosuppression Therapy / Q000379:methods*; D007279:Injections, Subcutaneous; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D016038:Skin Transplantation / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014184:Transplantation, Homologous
D006493:Heparin