Cytokines: IL-21 joins the gamma(c)-dependent network?
The discovery of the cytokine IL-21 adds another member to the ever-growing list of small secreted molecules that have potent effects on lymphoid cells. Initial characterization of the IL-21 receptor complex suggests that IL-21 may belong to the cytokine family whose receptors share the common gamma chain, gamma(c).
Unité des Cytokines et Développement Lymphoïde, Institut Pasteur, 25 rue du Dr Roux, 75742, Paris, France. vosshenr@pasteur.fr
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Vosshenrich
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Di Santo
D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000378:metabolism / Q000502:physiology; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D004268:DNA-Binding Proteins / Q000378:metabolism; D006801:Humans; D053738:Interleukin-21 Receptor alpha Subunit; D007378:Interleukins / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D053613:Janus Kinase 1; D007694:Killer Cells, Natural / Q000276:immunology* / Q000378:metabolism / Q000502:physiology; D008894:Milk Proteins; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D018123:Receptors, Interleukin / Q000145:classification / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D053655:Receptors, Interleukin-21; D050799:STAT5 Transcription Factor; D015398:Signal Transduction / Q000276:immunology*; D015534:Trans-Activators / Q000378:metabolism; D000098546:Interleukin-21
D004268:DNA-Binding Proteins; C508117:IL21R protein, human; D053738:Interleukin-21 Receptor alpha Subunit; D007378:Interleukins; D008894:Milk Proteins; D018123:Receptors, Interleukin; D053655:Receptors, Interleukin-21; D050799:STAT5 Transcription Factor; D015534:Trans-Activators; D011505:Protein-Tyrosine Kinases; C507904:JAK1 protein, human; D053613:Janus Kinase 1; D000098546:Interleukin-21