Hyperpyrexia secondary to acute hypocalcemic status. Is there a role for calcitonin therapy in bone metabolism derangements due to anticonvulsant drugs?
Hypocalcemia, hyperparathyroidism, hypovitaminosis D, hypocalcitoninemia and decreased bone mass are side effects of several anticonvulsant drugs. Since calcitonin inhibits the mineral mobilization of bone and augments minerals bone content, combined therapy with calcitonin, calcium, vitamin-C and vitamin-D was administrated to a patient with severe anticonvulsant disturbances of bone metabolism. Calcitonin hypersensitivity was evident. The symptomatology, characterized by the rare hypocalcemic hyperpyrexia, regressed after calcium infusion.
Department of Internal Medicine, Hospital of Lixouri, Lixouri, Greece.
P
P
Alexandropoulou
D
D
Mauri
E
E
Rigatou
V
V
Karampoiki
D000293:Adolescent; D000927:Anticonvulsants / Q000009:adverse effects*; D001205:Ascorbic Acid / Q000008:administration & dosage; D001842:Bone and Bones / Q000187:drug effects; D002116:Calcitonin / Q000627:therapeutic use*; D002118:Calcium / Q000008:administration & dosage; D005334:Fever / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D006996:Hypocalcemia / Q000097:blood / Q000139:chemically induced / Q000150:complications / Q000188:drug therapy*; D008297:Male
D000927:Anticonvulsants; D002116:Calcitonin; D001205:Ascorbic Acid; D002118:Calcium