[Genetic and biochemical studies on the regulatory mechanism of the self-resistance and biosynthesis of antibiotics].
The following topics are described: 1. chemistry of beta-lactamases; 2. beta-lactamases from Streptomyces including distribution of beta-lactamases in actinobacteria, properties of beta-lactamases from Streptomyces, cloning and regulatory mechanism of expression of beta-lactamase genes from Streptomyces and evolution and classification of beta-lactamases in general; 3. penicillin-binding proteins from Streptomyces including beta-lactam-producing- and non-producing strains and 4. eukaryotic-type protein kinases from Streptomyces including cloning of the genes and evolution and classification of eukaryotic-type protein kinases in general.
Department of Biochemistry, Meiji Pharmaceutical University, 2-522-1, Noshio, Kiyose, Tokyo 204-8588, Japan.
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Ogawara
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins; D002352:Carrier Proteins; D003001:Cloning, Molecular; D004352:Drug Resistance, Microbial; D019143:Evolution, Molecular; D015971:Gene Expression Regulation, Enzymologic; D006602:Hexosyltransferases; D008969:Molecular Sequence Data; D002267:Muramoylpentapeptide Carboxypeptidase; D046915:Penicillin-Binding Proteins; D010458:Peptidyl Transferases; D011355:Prodrugs; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics; D013302:Streptomyces / Q000201:enzymology / Q000378:metabolism; D001618:beta-Lactamases / Q000145:classification / Q000235:genetics; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D002352:Carrier Proteins; D046915:Penicillin-Binding Proteins; D011355:Prodrugs; D047090:beta-Lactams; D010458:Peptidyl Transferases; D006602:Hexosyltransferases; D011494:Protein Kinases; D002267:Muramoylpentapeptide Carboxypeptidase; D001618:beta-Lactamases