A new macrocyclic trichothecene, 12,13-deoxyroridin E, produced by the marine-derived fungus Myrothecium roridum collected in Palau.
A new macrocyclic trichothecene, 12,13-deoxyroridin E (1), and three known compounds, roridin E (2), verrucarin A (3), and verrucarin J (4), were obtained as cytotoxic components from the marine-derived fungus Myrothecium roridum, isolated in Palau. 12,13-Deoxyroridin E is the second example of a macrocyclic trichothecene possessing a double bond at C-12-C-13 and was about 80-fold less cytotoxic than roridin E, the epoxide variant.
Department of Ocean Sciences and Training Vessel Umitaka-maru, Tokyo University of Fisheries, Minato-ku, Tokyo 108-8477, Japan. namikosh@tokyo-u.fish.ac.jp
M
M
Namikoshi
K
K
Akano
S
S
Meguro
I
I
Kasuga
Y
Y
Mine
T
T
Takahashi
H
H
Kobayashi
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry*; D018922:HL-60 Cells; D006801:Humans; D007939:Leukemia L1210; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D015394:Molecular Structure; D009183:Mycotoxins / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D014255:Trichothecenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
C429609:12,13-deoxyroridin E; D000970:Antineoplastic Agents; D008387:Marine Toxins; D009183:Mycotoxins; D014255:Trichothecenes