Microbial transformation of hypoestenone.
Preparative-scale fermentation of hypoestenone (1) with Mucor ramannianus (ATCC 9628) has resulted in the isolation of 8(9)alpha-epoxyhypoestenone (2) and the new metabolites 8(9)alpha-epoxy-12,13-anhydrohypoestenone (3), 17-hydroxyhypoestenone (4), 13alpha,18-dihydroxyhypoestenone (5), and 13beta,18-dihydroxyhypoestenone (6). Structure elucidation of these metabolites was based primarily on 1D and 2D NMR analyses.
Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt. elsayed@yahoo.com
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El Sayed
D001711:Biotransformation; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida; D009089:Mucor / Q000378:metabolism*; D010936:Plant Extracts / Q000378:metabolism
D004224:Diterpenes; D010936:Plant Extracts; C428612:hypoestenone