Conservation of the rat X chromosome gene order in rodent species.
We constructed the comparative cytogenetic maps of X chromosomes in three rodent species, Indian spiny mouse (Mus platythrix), Syrian hamster and Chinese hamster, using 26 mouse cDNA clones. Twenty-six, 22 and 22 out of the 26 genes, which were mapped to human, mouse and rat X chromosomes in our previous study, were newly localized to X chromosomes of Indian spiny mouse, and Syrian and Chinese hamsters, respectively. The order of the genes aligned on the long arm of human X chromosome was highly conserved in rat and the three rodent species except mouse. The present results suggest a possibility that the rat X chromosome retains the ancestral form of the rodent X chromosomes.
Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo, Japan.
A
A
Kuroiwa
K
K
Tsuchiya
T
T
Watanabe
H
H
Hishigaki
E
E
Takahashi
T
T
Namikawa
Y
Y
Matsuda
D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D018076:DNA, Complementary / Q000378:metabolism; D019143:Evolution, Molecular; D017404:In Situ Hybridization, Fluorescence; D008647:Mesocricetus; D051379:Mice; D008957:Models, Genetic; D051381:Rats; D013045:Species Specificity; D014960:X Chromosome
D018076:DNA, Complementary