Newly diagnosed human immunodeficiency virus after sepsis-like reaction of trimethoprim-sulfamethoxazole.
A rare sepsis-like hypersensitivity reaction has been observed in persons with human immunodeficiency virus (HIV) after exposure to trimethoprim-sulfamethoxazole. This reaction most commonly occurs on rechallenge with the drug and is manifested by a syndrome resembling bacterial sepsis. The mechanism of this unusual reaction remains unclear. We describe the first case in which this severe hypersensitivity reaction was the initial manifestation of HIV.
Department of Infectious Diseases, Walter Reed Army Medical Center, Washington, DC 20307, USA.
K A
KA
Moran
N C
NC
Ales
P A
PA
Hemmer
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000209:etiology*; D015658:HIV Infections / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D008297:Male; D018805:Sepsis / Q000175:diagnosis / Q000209:etiology*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination