Experience with calcipotriol as adjunctive treatment for vitiligo in patients who do not respond to PUVA alone: a preliminary study.
BACKGROUND
PUVA therapy remains a primary treatment for vitiligo, despite unsatisfactory results. Because of calcipotriol's reported effects on melanocytes and on immunomodulatory and inflammatory mediators we wondered whether adding calcipotriol to PUVA would be more effective than PUVA alone in treating vitiligo.


OBJECTIVE
We sought to determine whether the combination of topical calcipotriol and PUVA therapy increases the responsiveness of patients with vitiligo refractory to PUVA alone.


METHODS
Twenty-one patients with vitiligo refractory to previous PUVA therapy were studied. Patients received 60 sessions of PUVA 3 times a week and 0.005% topical calcipotriol twice daily. Patients were monitored for repigmentation overall and on the trunk, extremities, and acral regions.


RESULTS
Starting at the median of the 17th treatment session, some degree of repigmentation was observed in 71.5% of the patients. After treatment, cosmetically acceptable overall repigmentation was observed in 29% of patients; repigmentation of lesions on the trunk, extremities, and acral region was noted in 36%, 58%, and 0% of patients, respectively. Adverse reactions were mild and tolerable.


CONCLUSIONS
The combination of PUVA and calcipotriol may be effective therapy and should be further investigated for the treatment of vitiligo.
Department of Dermatology, Hacettepe University School of Medicine, Ankara, Turkey.
B
B
Yalçin
S
S
Sahin
G
G
Bükülmez
A
A
Karaduman
N
N
Atakan
T
T
Akan
F
F
Kölemen
D000328:Adult; D000368:Aged; D002117:Calcitriol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003879:Dermatologic Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D011446:Prospective Studies; D017211:Treatment Failure; D014820:Vitiligo / Q000188:drug therapy*
D003879:Dermatologic Agents; C055085:calcipotriene; D002117:Calcitriol