Effects of testosterone and clomiphene on spectral EEG and visual evoked response in a young man with posttraumatic epilepsy.
The effects of testosterone and clomiphene on epilepsy was studied in a young man with posttraumatic seizures. In the control period, digital EEG and visual evoked potentials (VEPs) were recorded under carbamazapine therapy. After testosterone (T), seizures lessened and almost disappeared; the theta, delta, alpha, and beta powers decreased; VEPs increased. After clomiphene, VEPs considerably increased in size; clinical picture slightly improved; EEG power spectrum remained unchanged. It was suggested that T may be beneficial for epilepsy treatment by suppressing the EEG synchronization (slow wave activity) and attenuating the entropy state of the epileptic brain.
Tan
M
M
Department of Neurology, Medical Faculty, Karadeniz Technical University, Trabzon, Turkey.
Tan
U
U
D000293:Adolescent; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004834:Epilepsy, Post-Traumatic / Q000188:drug therapy*; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D008297:Male; D013739:Testosterone / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D016896:Treatment Outcome
D004965:Estrogen Antagonists; D002996:Clomiphene; D013739:Testosterone