A novel HLA-DRB1 sequence, DRB1*11272.
We describe the complete exon 2 sequence of a novel HLA-DRB1 allele, DRB1*11272. This allele differs from the DRB1*11271 allele by a synonymous mutation in codon 77 where an AAT is replaced with AAC, both encode for the amino acid asparagine. The same motif at codon 77 has also been found in DRB1*1107, DRB1*1333, DRB1*0422 and in most DRB1*03 alleles. A partial exon 2 sequence of this allele has previously been deposited in the EMBL Sequence Database under the accession number AF186407.
Department of Blood Group Serology and Transfusion Medicine, Universitaetsklinik Graz, Graz, Austria.
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S
Ulrich
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Helmberg
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T
Wagner
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Corell
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Marsh
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Lanzer
D000483:Alleles; D001216:Asparagine / Q000235:genetics; D001483:Base Sequence; D005091:Exons; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data; D017354:Point Mutation
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553519:HLA-DRB1*11:27:02 antigen; D001216:Asparagine