Human leukocyte antigens related to Epstein-Barr virus-associated gastric carcinoma in Japanese patients.
To assess the association between specific types of human leukocyte antigen and the risk of Epstein-Barr virus (EBV)-associated gastric carcinoma, serological typing for major histocompatibility complex class I and class II antigens was performed for 110 EBV-positive and 155 EBV-negative gastric carcinoma cases. In class I analysis, the frequency of B59 in the EBV-positive cases was higher than for the EBV-negative cases (odds ratio (OR) 3.06; 95% confidence interval (CI) 1.02-9.23). For class II antigens, DQ3 and DR9 frequencies in the EBV-positive cases were higher (OR 1.94; 95% CI 1.16-3.24 and OR 1.93; 95% CI 1.11-3.37, respectively), whereas DR11 frequency was lower than found in the EBV-negative cases (OR 0.10; 95% CI 0.01-0.79). After adjusting for multiple comparisons, only DR11 frequency remained significantly lower in the EBV-positive cases (P = 0.04), and the association of DQ3 was marginally significant (P = 0.05). These results suggest that the presence of DR11-restricted cytotoxic T cells (CTLs) related to EBV-associated gastric carcinoma, or a deficiency of DR11 and a high frequency of DQ3 may be genetic markers for a population at greater risk of EBV-associated gastric carcinoma. However, further extensive studies to more cases and DNA typing are needed because our findings in this study are exploratory.
Department of Public Health, Faculty of Medicine, Kagoshima University, Japan. fiy@m.kufm.kagoshima-u.ac.jp
C
C
Koriyama
R
R
Shinkura
Y
Y
Hamasaki
T
T
Fujiyoshi
Y
Y
Eizuru
M
M
Tokunaga
D020031:Epstein-Barr Virus Infections / Q000235:genetics / Q000276:immunology*; D005260:Female; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D007564:Japan; D008297:Male; D013274:Stomach Neoplasms / Q000235:genetics / Q000276:immunology* / Q000821:virology*
D006680:HLA Antigens