Aerosolized iloprost for severe pulmonary hypertension as a bridge to heart transplantation.
Preexisting pulmonary hypertension in pediatric patients is associated with poor outcome after cardiac transplantation because of donor right ventricular dysfunction. To avoid a combined heart-lung transplantation in a 17-year-old patient, we used an intensified pretreatment with intravenous prostacyclin and dobutamine combined with an inhalative therapy with the aerosolized prostacyclin-analog Iloprost. With this regimen, the patient was hemodynamically stabilized for the waiting period of 21 days after which an uneventful cardiac transplantation was performed.
Wittwer
T
T
Department of Thoracic, Medical School Hannover, Germany. th.wittwer-md@t-online.de
Pethig
K
K
Strüber
M
M
Hoeper
M
M
Harringer
W
W
Haverich
A
A
Franke
U
U
Wahlers
T
T
D000293:Adolescent; D000336:Aerosols; D002317:Cardiovascular Agents / Q000008:administration & dosage*; D016027:Heart Transplantation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D016285:Iloprost / Q000008:administration & dosage*; D008297:Male; D011300:Preoperative Care; D012720:Severity of Illness Index
D000336:Aerosols; D002317:Cardiovascular Agents; D016285:Iloprost