Intramolecular glycosylation under neutral conditions for synthesis of 1,4-linked disaccharides.
[structure: see text]. A new method for intramolecular glycosylation, in which the donor and acceptor were linked via a 3,5-dinitrosalicylic acid derivative, was developed. Simply dissolving the tethered glycoside in CH3NO2 and warming to 40-60 degrees C led to formation of 1,4-linked disaccharides under neutral, hence, exceptionally mild, conditions.
Department of Chemistry, Technical University of Denmark, Building 201, Kemitorvet, DK-2800 Kgs. Lyngby, Denmark.
J B
JB
Laursen
L
L
Petersen
K J
KJ
Jensen
D004187:Disaccharides / Q000138:chemical synthesis*; D006031:Glycosylation; D006868:Hydrolysis
D004187:Disaccharides