Production and characterisation of highly concentrated nanosuspensions by high pressure homogenisation.
Nanosuspensions produced by high-pressure homogenisation are a solution for the formulation of poorly soluble drugs with bioavailability problems. The typical solid concentration of the nanosuspensions is 10%. However, to transfer the nanosuspensions to a dry product (e.g. granulation, tablets, pellets), a higher solid content is required to remove less water. Nanosuspensions with 20 and 30% solid content were produced, the effect of surfactant concentration assessed and their quality (size data) compared with the lower standard concentrations of 1-10% solid.
Department of Pharmaceutics, Biopharmaceutics and Biotechnology, Free University of Berlin, Kelchstrasse 31, 12169 Berlin, Germany.
K P
KP
Krause
R H
RH
Müller
D010316:Particle Size; D011312:Pressure; D012995:Solubility; D013501:Surface-Active Agents / Q000494:pharmacology; D013535:Suspensions; D013678:Technology, Pharmaceutical
D013501:Surface-Active Agents; D013535:Suspensions