[Study on the inhibition of tea pigments on the adhesion between monocyte and endothelial cells].
In order to study the effects of tea pigments (TP) on the adhesion between monocyte and endothelial cells induced by oxidized low density lipoprotein(Ox-LDL), the fluorescence activated cell sorter (FACS) and the cell ELISA were applied. The results showed that TP could inhibit the adhesion between monocyte and endothelial cells(P < 0.05), and the expression of inter cell adhesion molecule(ICAM-1) and vascular cell adhesion molecule (VCAM-1) proteins in a dose dependent manner(P < 0.05). The results suggested that the inhibition of TP on ICAM-1 and VCAM-1 expression was one of the mechanisms of its antiadhesion between monocyte and vascular endothelial cells, as well as that of its antiatherosclerosis.
Xuan
W
W
Institute of Nutrition and Food Hygiene, Chinese Academy of Preventive Medicine, Beijing 100050, China.
Wang
S
S
Han
C
C
Chen
J
J
D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D008077:Lipoproteins, LDL / Q000494:pharmacology; D009000:Monocytes / Q000166:cytology* / Q000187:drug effects; D010860:Pigments, Biological / Q000494:pharmacology*; D013662:Tea / Q000737:chemistry*; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis
D008077:Lipoproteins, LDL; D010860:Pigments, Biological; D013662:Tea; D019010:Vascular Cell Adhesion Molecule-1; C099252:oxidized low density lipoprotein; D018799:Intercellular Adhesion Molecule-1