Three new triterpenes from the seeds of Combretum quadrangulare and their hepatoprotective activity.
Three new triterpenes of the lupane type, 2alpha,6beta-dihydroxybetulinic acid (1) and 6beta-hydroxyhovenic acid (2), and an oleanane type, 6beta-hydroxyarjunic acid (3), together with several known compounds, have been isolated from the MeOH extract of the seeds of Combretum quadrangulare. The structures of these compounds were elucidated on the basis of spectroscopic analysis, and their hepatoprotective activities were tested for D-GalN/TNF-alpha-induced cell death in primary cultured mouse hepatocytes.
Adnyana
I K
IK
Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630-Sugitani, Toyama 930-0194, Japan.
Tezuka
Y
Y
Banskota
A H
AH
Tran
K Q
KQ
Kadota
S
S
D001208:Asia; D008099:Liver / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D020011:Protective Agents; D019685:Rosales / Q000737:chemistry; D012639:Seeds / Q000737:chemistry; D014197:Trees / Q000737:chemistry*; D014315:Triterpenes / Q000302:isolation & purification*
D020011:Protective Agents; D014315:Triterpenes