Recombinant granulocyte colony-stimulating factor (G-CSF) in infectious diseases: still a debate.
Granulocyte colony-stimulating factor (G-CSF), a central mediator of the endogenous response to infection and inflammation, is approved for use in the prevention of infection-related complications in patients with nonmyeloid malignancies during antineoplastic therapy associated with high risk of severe neutropenia. Administration of granulocyte colony-stimulating factor results in improvement of host defence paired with anti-inflammatory effects. There is evidence from animal and clinical studies that administration of granulocyte colony-stimulating factor may also be beneficial in non-neutropenic infections. This review focuses mainly on the results of different animal and clinical studies of granulocyte colony stimulating factor used in the treatment of severe infections and sepsis.
Wiedermann
F J
FJ
Division of General and Surgical Intensive Care Medicine, Department of Anaesthesia and Intensive Care Medicine, Leopold-Franzens-University of Innsbruck, Austria.
Mittermayr
M
M
Hoffmann
G
G
Schobersberger
W
W
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy*; D001930:Brain Injuries / Q000150:complications; D002986:Clinical Trials as Topic; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D006168:Guinea Pigs; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy; D009503:Neutropenia / Q000188:drug therapy / Q000209:etiology; D010919:Placebos; D018410:Pneumonia, Bacterial / Q000188:drug therapy; D016032:Randomized Controlled Trials as Topic; D051381:Rats; D011994:Recombinant Proteins; D012128:Respiratory Distress Syndrome / Q000150:complications; D012307:Risk Factors; D018805:Sepsis / Q000188:drug therapy* / Q000209:etiology; D012756:Sheep; D012771:Shock, Hemorrhagic / Q000188:drug therapy; D012772:Shock, Septic / Q000188:drug therapy; D013552:Swine
D000900:Anti-Bacterial Agents; D010919:Placebos; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim