Biosynthesis of the bicycloalternarenes, mixed terpenoids of Alternaria alternata.
By incorporation of [2-13C]-mevalonate, [1-13C]-acetate and [1-13C]-glucose we could reveal that the phytopathogenic fungus Alternaria alternata biosynthesized the mixed terpenoids bicycloalternarenes via the classic mevalonate pathway. The polyketid pathway does not participate in the biosynthesis of bicycloalternarenes, because there is no incorporation of [13C]-acetate into the C-ring of these compounds. The labelling pattern in this nonterpenoid part of bicycloalternarenes after feeding with [1-13C]-glucose and [U-13C6]-glucose, respectively, allows the assumption that metabolites of the shikimate pathway are involved.
Biologisch-Pharmazeutische Fakultät der Friedrich-Schiller-Universität Jena, Institut für Pharmazie, Germany. bernd.liebermann@rz.uni-jena.de
B
B
Liebermann
R P
RP
Nussbaum
W
W
Günther
J M
JM
Teuscher
D000085:Acetates / Q000378:metabolism; D000528:Alternaria / Q000378:metabolism*; D002247:Carbon Isotopes; D005947:Glucose / Q000378:metabolism; D007700:Kinetics; D008798:Mevalonic Acid / Q000378:metabolism; D015394:Molecular Structure; D013729:Terpenes / Q000737:chemistry / Q000378:metabolism*
D000085:Acetates; D002247:Carbon Isotopes; D013729:Terpenes; D005947:Glucose; D008798:Mevalonic Acid