Helicobacter pylori: current chemotherapy and new targets for drug design.
Helicobacter pylori infection is a major cause of many diseases of the gastrointestinal tract, including gastritis, non-ulcer dyspepsia, peptic ulcer disease, and gastric cancers. It is estimated that more than half of the human race is affected by this organism. Although effective treatments are available which will eliminate the organism in about 90 percent; of cases in developed countries, the pandemic occurrence of Helicobacter pylori infection coupled with its ability to develop resistance to our current arsenal of antimicrobial regimens and subsequently reinfect patients makes the pathogenic potential of this microorganism a major global health concern. Provided is a review of the current and evolving therapeutic regimens used in the eradication of Helicobacter pylori, the difficulties associated with in vitro drug screening, as well as potentially new therapeutic targets. In addition, the discovery, the unique physiology, biochemistry, and pathogenicity of this remarkable microorganism is examined.
Williamson
J S
JS
Department of Medicinal Chemistry, University of Mississippi, Mississippi, MS 38677, USA. mcjsw@olemiss.edu
D001422:Bacterial Adhesion; D001428:Bacterial Vaccines / Q000276:immunology; D015195:Drug Design; D016481:Helicobacter Infections / Q000188:drug therapy* / Q000635:transmission; D016480:Helicobacter pylori / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration
D001428:Bacterial Vaccines