Expression of dominant-negative STAT5 inhibits growth hormone- and prolactin-induced proliferation of insulin-producing cells.
Galsgaard
E D
ED
Hagedorn Research Institute, Department of Cell Biology, Gentofte, Denmark. edgalsgaard@imbg.ku.dk
Friedrichsen
B N
BN
Nielsen
J H
JH
Møldrup
A
A
D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D004274:DNA, Recombinant; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000494:pharmacology; D015870:Gene Expression / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D019382:Human Growth Hormone / Q000494:pharmacology*; D006801:Humans; D007328:Insulin / Q000096:biosynthesis*; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008894:Milk Proteins; D010957:Plasmids / Q000235:genetics; D011388:Prolactin / Q000494:pharmacology*; D051381:Rats; D011981:Receptors, Prolactin / Q000235:genetics; D050799:STAT5 Transcription Factor; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014162:Transfection; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000378:metabolism
D000900:Anti-Bacterial Agents; D004274:DNA, Recombinant; D004268:DNA-Binding Proteins; D007328:Insulin; D008894:Milk Proteins; D011981:Receptors, Prolactin; D050799:STAT5 Transcription Factor; D015534:Trans-Activators; D019382:Human Growth Hormone; D011388:Prolactin; D004318:Doxycycline