Isolation and identification of a phenolic antioxidant from Aloe barbadensis.
A potent antioxidative compound has been isolated from a methanolic extract of Aloe barbadensis Miller using a combination of column and thin-layer chromatography. The antioxidant activity of this substance was similar to that of alpha-tocopherol as assessed in vitro using rat brain homogenates. On the basis of electrospray ionization and electron-impact ionization mass spectra in combination with reversed-phase, high-performance liquid chromatographic behavior, this compound has been identified as 8-C-beta-D-[2-O-(E)-coumaroyl]glucopyranosyl-2-[2-hydroxy]-propyl-7-methoxy-5-methylchromone.
Department of Food and Nutrition, Ho Seo University, Asan, Chungmam, Korea.
K Y
KY
Lee
S T
ST
Weintraub
B P
BP
Yu
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000504:Aloe / Q000737:chemistry*; D000818:Animals; D000975:Antioxidants / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D002867:Chromones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D015394:Molecular Structure; D009249:NADP / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D011916:Rats, Inbred F344; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis; D014810:Vitamin E / Q000494:pharmacology
C100862:8-(2-O-cinnamoyl(glucopyranosyl))-2-(2-hydroxypropyl)-7-methoxy-5-methylchromone; D000975:Antioxidants; D002867:Chromones; D010936:Plant Extracts; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D009249:NADP; D000244:Adenosine Diphosphate