[A new melanoma antigen-encoding gene subfamily in human chromosome X].
A lot of studies have been focused on the tumor-related genes. We have cloned a new melanoma antigen-encoding gene (MAGE) from human fetal liver of third trimester and subsequently found that it represented a new MAGE gene subfamily, named MAGE-D. The MAGE-D subfamily contained three orthologs including human MAGE-D1, rat SNERG-1 and mouse DLXIN-1, and two paralogs including human MAGE-D and human KIAA1114. All human members of MAGE-D subfamily are located in human chromosome Xp11.21-p11.23. Moreover, MAGE-D subfamily stands out from other known subfamilies MAGE-A, -B and -C of MAGE family in view of typical features such as exon/intron organization, absence of tumorspecific antigens, evolutionarily divergent in sequences. The identification of MAGE-D subfamily will be helpful in understanding the genesis of tumor.
Zhang
C G
CG
Beijing Institute of Radiation Medicine, Beijing 100850, China.
Xing
G C
GC
Wei
H D
HD
Yu
Y T
YT
He
F C
FC
D000595:Amino Acid Sequence; D000818:Animals; D000951:Antigens, Neoplasm / Q000235:genetics*; D006801:Humans; D008545:Melanoma / Q000276:immunology*; D051379:Mice; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics*; D051381:Rats; D014960:X Chromosome
D000951:Antigens, Neoplasm; C120897:MAGED1 protein, human; C486541:Maged1 protein, mouse; C486542:Maged1 protein, rat; D009363:Neoplasm Proteins