In vitro antimicrobial activity of aromatic diamidines and diimidazolines related to pentamidine.
Geometric isomers of pentamidine analogues were screened for antimicrobial activity in vitro. cis isomers demonstrated good antibacterial activity compared to their trans counterparts. Both isomers were moderately active against opportunistic pathogens that afflict AIDS patients with minimum inhibitory concentrations in the range of 3.12-12.5 microg/mL.
Department of Pharmaceutical Sciences, College of Pharmacy, The University of Tennessee, Memphis 38163, USA.
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Donkor
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Clark
D017088:AIDS-Related Opportunistic Infections / Q000382:microbiology; D000578:Amidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001232:Aspergillus fumigatus / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D003455:Cryptococcus neoformans / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015269:Mycobacterium avium Complex / Q000187:drug effects; D010419:Pentamidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D000578:Amidines; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D007093:Imidazoles; D010419:Pentamidine