Use of ultrasound to prepare lipid emulsions of lorazepam for intravenous injection.
Lipid emulsions can be used as a vehicle for the production of low-volume injectable preparations with minimally water-soluble active ingredients. First, we focus on the galenic and technological conditions established by ultrasound techniques. A 2(5) factorial design was used to optimize the carrier emulsion. The study then deals with the development of a parenteral emulsion formulation for lorazepam (1 mg/ml), which is compared with the highest concentration (0.05 mg/ml) achieved in the optimal aqueous diluent for lorazepam (dextrose 5% in water). The physical and chemical stability of lorazepam in the emulsion was examined for 7 months.
Unitat de Tecnologia Farmacèutica, Departament de Farmàcia i Tecnologia Farmacèutica, Plaza Piu XII s/n, Facultat de Farmàcia, Universitat de Barcelona, Barcelona 08028, Spain.
J
J
Medina
A
A
Salvadó
A
A
del Pozo
D000704:Analysis of Variance; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D004356:Drug Storage; D005217:Fat Emulsions, Intravenous; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008140:Lorazepam / Q000008:administration & dosage*; D010316:Particle Size; D014465:Ultrasonics
D005217:Fat Emulsions, Intravenous; D006993:Hypnotics and Sedatives; D008140:Lorazepam