[Clinical analysis of 164 cases Coombs test positive autoimmune hemolytic anemia].
OBJECTIVE
To analyze the clinical features and treatment outcomes of autoimmune hemolytic anemia (AIHA).


METHODS
Coombs test positive AIHA patients were retrospectively analyzed.


RESULTS
Patients with AIHA were predominantly female, secondary AIHA accounted for 49% of the total cases, mainly associated with connective tissue diseases. In most cases of AIHA, the anti-red cell antibodies were IgG plus C3, while patients with IgG plus IgM had more severe clinical manifestations. The response rate of adrenocortical hormones and cyclosporin A (CsA) was 90.9%.


CONCLUSIONS
Adrenocorticosteroids is still the first choice of therapy for AIHA, CsA can improve the response rate.
Zhang
Y
Y
Institute of Hematology and Blood Diseases Hospital, CAMS and PUMC, Tianjin 300020.
Chu
Y
Y
Chen
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000744:Anemia, Hemolytic, Autoimmune / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003298:Coombs Test; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D012189:Retrospective Studies; D016896:Treatment Outcome
D016572:Cyclosporine; D011241:Prednisone