Decreased longevity in Japanese men, associated with low-molecular-weight apolipoprotein(a) phenotypes.
Lipoprotein(a) [Lp(a)] is an established risk factor for atherosclerosis. High plasma Lp(a) concentrations are associated with low-molecular-weight (LMW) apolipoprotein(a) (apo a) phenotypes, which raises the question of whether LMW apo a phenotypes occur less frequently in the elderly. To assess this possibility, we studied apo A phenotype and allele frequencies in Japanese subjects > or = 80 years old (men:women = 40:34) in comparison with those <80 years old (men:women = 221:296). Significantly fewer LMW phenotypes and LMW alleles were observed in > or = 80 year old men compared with those < 80 years old: 2.5% versus 16.1% for the LMW phenotype frequency and 1.3% versus 9.7% for the LMW allele frequency (P<0.05, Fisher's exact probability test). Similar differences were not found in the women. Consistent with this, plasma Lp(a) concentrations were significantly lower in the men > or = 80 years old than in the younger group. These results indicate that LMW apo a phenotypes are associated with a shorter lifespan in men but not in women, possibly reflecting the higher susceptibility of men to atherosclerosis.
Matsubara
M
M
Department of Internal Medicine, Otaru City General Hospital, Otaru, Japan.
Akita
H
H
Shibuya
H
H
Chiba
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over / Q000502:physiology*; D001054:Apolipoproteins A / Q000032:analysis / Q000097:blood / Q000235:genetics*; D001161:Arteriosclerosis / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics*; D006801:Humans; D007564:Japan; D017270:Lipoprotein(a) / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D010641:Phenotype; D012307:Risk Factors
D001054:Apolipoproteins A; D017270:Lipoprotein(a)