Effect of physical training on sulfamethazine acetylation rate.
We studied the rate of sulfamethazine acetylation in athletes and untrained controls aging 18-22 years. The rate of sulfamethazine acetylation in controls was characterized by a bimodal distribution: rapid and slow acetylators constituted 42 and 58%, respectively. The rate of sulfamethazine biotransformation in athletes was characterized by a trimodal distribution: ultrarapid, rapid, and slow xenobiotic acetylators constituted 48.4, 22.6, and 29%, respectively. The ultrarapid acetylation phenotype was probably associated with N-acetyltransferase induction and reflected adaptation to physical exercises
Pedagogical University; Technology University, Kazan'. razina@kspu.kcn.ru
R A
RA
Abzalov
R R
RR
Nigmatullina
G N
GN
Khairullina
S Y
SY
Garmonov
L S
LS
Shakirova
M I
MI
Evgen'ev
D000107:Acetylation; D000222:Adaptation, Physiological; D000293:Adolescent; D000328:Adult; D001711:Biotransformation; D016022:Case-Control Studies; D015444:Exercise / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D010641:Phenotype; D010806:Physical Education and Training; D013177:Sports; D013418:Sulfamethazine / Q000493:pharmacokinetics*
D013418:Sulfamethazine