Microscopic polyangiitis presenting as idiopathic pulmonary fibrosis: is anti-neutrophilic cytoplasmic antibody testing indicated?
We report a 55-year old woman with microscopic polyangiitis who presented with idiopathic pulmonary fibrosis and 1 year later developed hematuria and proteinuria. She had a high serum level of perinuclear anti-neutrophilic cytoplasmic antibodies. Renal angiogram was normal. The diagnosis of microscopic polyangiitis was confirmed by renal biopsy, which showed pauci-immune crescentic glomerulonephritis. The patient received immunosuppressive therapy and improved markedly. Consideration of small vessel vasculitis is important in the differential diagnosis of idiopathic pulmonary fibrosis.
Mansi
I A
IA
Department of Medicine, Queens Hospital Center, Jamaica, New York 11432, USA.
Opran
A
A
Sondhi
D
D
Ayinla
R
R
Rosner
F
F
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000032:analysis*; D005260:Female; D005921:Glomerulonephritis; D006417:Hematuria; D006801:Humans; D008875:Middle Aged; D011507:Proteinuria; D011658:Pulmonary Fibrosis / Q000150:complications / Q000175:diagnosis*; D014657:Vasculitis / Q000150:complications / Q000175:diagnosis*
D019268:Antibodies, Antineutrophil Cytoplasmic