[The study of PCNA expression and AgNORs counting adult-onset laryngeal papilloma].
Avidin-Biotin-peroxidase Complex technique (ABC) and silver staining technique were used to study the relationship between proliferative activity and the biological status of adult-onset laryngeal papilloma. The proliferating index of PCNA positive cells was closely related to AgNORs count. The two indices were significantly different among these groups (P < 0.05).


CONCLUSIONS
PCNA expression and AgNORs count are useful in distinguishing between benign and malignant laryngeal neoplasms, monitoring premalignancy and observing tumor biological activity.
Wang
T
T
Department of Otorhinolaryngology, Second Clinical Hospital, China Medical University, Shenyang 110003.
Wang
D
D
D002471:Cell Transformation, Neoplastic; D006801:Humans; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology; D009687:Nuclear Proteins / Q000032:analysis; D009697:Nucleolus Organizer Region / Q000737:chemistry; D010212:Papilloma / Q000737:chemistry* / Q000473:pathology; D011230:Precancerous Conditions / Q000737:chemistry* / Q000473:pathology; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D016622:Silver Staining
D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen