Effect of fibrin bandage fibrinogen concentration on blood loss after grade V liver injury in swine.
OBJECTIVE
To determine the effect of fibrinogen concentration of dry fibrin bandages on blood loss after grade V liver injury.


METHODS
Twenty-four pigs were used. Grade V liver injuries were induced and treated with dry fibrin bandages containing 0, 4, 8, or 15 mg fibrinogen/cm2. Animals were monitored for 60 minutes. Blood loss, fluid use, hematological data, and hemostasis were assessed.


RESULTS
Post-treatment blood losses (mean and 95% confidence interval [CI]) were 1,560 mL (356-6,844), 372 mL (65-2,134), 225 mL (51-992), and 127 mL (22-732) in the 0-, 4-, 8-, and 15-mg groups, respectively. Only the 15-mg group had results significantly lower than the 0-mg group (p < 0.05). Blood loss was negatively related to fibrinogen concentration (p < 0.05).


CONCLUSIONS
Fibrinogen concentration was inversely related to blood loss after grade V liver injury. The 15-mg formulation was the only one that significantly reduced blood loss.
Department of Clinical Investigation, William Beaumont Army Medical Center, El Paso, TX, USA.
A E
AE
Pusateri
J B
JB
Holcomb
R A
RA
Harris
M J
MJ
MacPhee
N C
NC
Charles
L D
LD
Beall
J R
JR
Hess
D000818:Animals; D001458:Bandages / Q000592:standards; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D005340:Fibrinogen / Q000032:analysis*; D006454:Hemoglobins / Q000032:analysis; D006470:Hemorrhage / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology*; D015601:Injury Severity Score; D008099:Liver / Q000293:injuries*; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011516:Prothrombin; D013552:Swine
D006454:Hemoglobins; D011516:Prothrombin; D005337:Fibrin; D005340:Fibrinogen