Genetics and molecular genetics of the MHC.
The MHC is a well-characterised region of the human genome, containing a high diversity of genes and an apparent clustering of genes involved in the immune response. The genomic sequence of an 8 Mb section, containing the MHC and flanking regions and covering over 300 genes, will soon be available. Since this is a highly polymorphic region, the molecular genetics of the MHC and its relationship with disease have been studied in considerable detail.
Rhodes
D A
DA
Department of Pathology, University of Cambridge, UK. drhodes@hgmp.mrc.ac.uk
Trowsdale
J
J
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics; D002874:Chromosome Mapping; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D006432:Hemochromatosis / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000235:genetics*; D008967:Molecular Biology; D011110:Polymorphism, Genetic