Stimulation of protein biosynthesis in rat hepatocytes by extracts of Momordica charantia.
The in vivo effect of the administration of extracts of Momordica charantia on certain biochemical parameters of Sprague-Dawley rats was investigated. It was observed that there was an increase in muscle and liver protein levels, while there was a reduction in the levels of brain protein, muscle and liver glycogen. The activities of plasma L-alanine transaminase and alkaline phosphatase were reduced. The L-aspartate transaminase and adenosine triphosphatase activities were slightly elevated in whole plant extract treated rats while the L-aspartate transaminase was unaffected by the ethanol extract but reduced the adenosine triphosphatase activity.
Araba
B G
BG
Department of Biochemistry, Obafemi Awolowo University, Ile-Ife, Nigeria.
D000410:Alanine Transaminase / Q000097:blood*; D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D019662:Cucurbitaceae; D005260:Female; D022781:Hepatocytes / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D010936:Plant Extracts; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase