Intravenous theophylline--an alternative to temporary pacing in the management of bradycardia secondary to AV nodal block.
OBJECTIVE
To report a case of bradycardia secondary to atrioventricular nodal block (AVNB) successfully treated with intravenous theophylline. Intravenous theophylline was used as an alternative to temporary pacing in a patient with sepsis secondary to thermal injury.


METHODS
A 79-year-old white woman with significant cardiac history was admitted with 14.5% total body surface area burns after a house fire. Cardiac events included intermittent episodes of sinus bradycardia complicated by the development of second-degree AVNB and periods of sinus arrest. Intravenous theophylline initiation maintained normal sinus rhythm without further episodes of sinus bradycardia or heart block, thus preventing the need for cardiac pacemaker placement.


CONCLUSIONS
This is the first case published in the English-language literature describing the use of intravenous theophylline as an alternative therapy to temporary pacing in a patient with sepsis secondary to thermal injury. Bradyarrhythmic events in sepsis patients have been associated with catecholamine production increasing adenosine formation. High concentrations of adenosine in the areas of the sinoatrial or atrioventricular nodal regions may induce sinus bradycardia or AVNB. Theophylline, an adenosine antagonist, has been identified as a treatment option for such bradyarrhythmic events.


CONCLUSIONS
Theophylline, a methylxanthine derivative, may represent an alternative to other pharmacologic therapies and temporary pacing in the treatment of bradycardia secondary to AVNB. These agents may represent a pharmacologic alternative in patients in whom other pharmacologic strategies or cardiac pacemaker insertion may be contraindicated.
Department of Pharmacy Practice and Pharmacy Administration, Philadelphia College of Pharmacy, University of the Sciences in Philadelphia, PA 19104-4495, USA. m.cawley@usip.edu
M J
MJ
Cawley
A S
AS
Al-Jazairi
E A
EA
Stone
D000368:Aged; D001919:Bradycardia / Q000188:drug therapy* / Q000209:etiology*; D002056:Burns / Q000150:complications; D002304:Cardiac Pacing, Artificial; D005260:Female; D006327:Heart Block / Q000150:complications*; D006801:Humans; D007275:Injections, Intravenous; D018805:Sepsis / Q000150:complications; D013806:Theophylline / Q000008:administration & dosage / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D014665:Vasodilator Agents; D013806:Theophylline