Endogenous DNA damage and mutation.
In humans, approximately 10(7) cells divide per second. Estimates suggest that spontaneous mutations arise in about a third of those cells. These mutations arise as mistakes in DNA replication and when DNA polymerases copy damaged templates. The latter result from chemical hydrolysis of nucleoside bases or by reaction of DNA with electrophiles or reactive free radicals generated during metabolism (endogenous DNA damaging agents). This article highlights recent discoveries and emerging opportunities in the study of endogenous DNA damage and mutation.
A.B. Hancock Jr Memorial Laboratory for Cancer Research, Vanderbilt-Ingram Cancer Center, Center in Molecular Toxicology, Dept of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. marnett@toxicology.mc.vanderbilt.edu
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D000818:Animals; D002455:Cell Division; D002869:Chromosome Aberrations; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000502:physiology; D005609:Free Radicals; D006801:Humans; D009154:Mutation
D005609:Free Radicals; D004259:DNA-Directed DNA Polymerase