Neural consequences of environmental enrichment.
Neuronal plasticity is a central theme of modern neurobiology, from cellular and molecular mechanisms of synapse formation in Drosophila to behavioural recovery from strokes in elderly humans. Although the methods used to measure plastic responses differ, the stimuli required to elicit plasticity are thought to be activity-dependent. In this article, we focus on the neuronal changes that occur in response to complex stimulation by an enriched environment. We emphasize the behavioural and neurobiological consequences of specific elements of enrichment, especially exercise and learning.
van Praag
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Salk Institute for Biological Studies, La Jolla, California 92037, USA. gage@salk.edu
Kempermann
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G
Gage
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FH
D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development*; D002455:Cell Division / Q000502:physiology; D004780:Environment, Controlled; D006801:Humans; D009473:Neuronal Plasticity / Q000502:physiology*; D012683:Sensory Deprivation / Q000502:physiology