Nutrient intake and hypertensive disorders of pregnancy: Evidence from a large prospective cohort.
OBJECTIVE
The objective of this analysis was to prospectively determine the effects of nutrient intakes on the incidences of preeclampsia and pregnancy-associated hypertension among women enrolled in the Calcium for Preeclampsia Prevention study.


METHODS
This was a prospective observational cohort study of women in a randomized clinical trial that included women seeking prenatal care at university medical centers and affiliated clinics and hospitals in 5 US communities. A total of 4589 nulliparous women were recruited between 13 and 21 weeks' gestation. Preeclampsia and pregnancy-associated hypertension were the main outcome measures.


RESULTS
Preeclampsia was noted in 326 (7.6%) of the 4314 women with known pregnancy outcomes followed up until > or =20 weeks' gestation, and pregnancy-associated hypertension was noted in 747 (17.3%). As previously reported, there was no significant difference in these outcomes between cohorts randomly assigned to supplementation with calcium or placebo. By means of logistic regression a baseline risk model was constructed for preeclampsia and pregnancy-associated hypertension. After adjustment for treatment and clinical site, body mass index >26 kg/m(2) and race were significantly associated with an increased risk of preeclampsia. Body mass index > or =35 kg/m(2), race, and never smoking were significantly associated with an increased risk of pregnancy-associated hypertension. After adjustment for baseline risks, none of the 28 nutritional factors analyzed were significantly related to either preeclampsia or pregnancy-associated hypertension.


CONCLUSIONS
We found no evidence in this study for a significant association of hypertensive disorders of pregnancy with any of the 23 nutrients measured.
Division of Medical Informatics and Outcomes Research, Oregon Health Sciences University, USA.
C D
CD
Morris
S L
SL
Jacobson
R
R
Anand
M G
MG
Ewell
J C
JC
Hauth
L B
LB
Curet
P M
PM
Catalano
B M
BM
Sibai
R J
RJ
Levine
D015992:Body Mass Index; D002118:Calcium / Q000008:administration & dosage; D015331:Cohort Studies; D019587:Dietary Supplements; D002149:Energy Intake; D005260:Female; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000150:complications*; D016015:Logistic Models; D009747:Nutritional Physiological Phenomena; D010919:Placebos; D011225:Pre-Eclampsia / Q000150:complications; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011256:Pregnancy Outcome; D011446:Prospective Studies; D044469:Racial Groups; D012907:Smoking; D014815:Vitamins / Q000008:administration & dosage
D010919:Placebos; D014815:Vitamins; D002118:Calcium