Effect of endothelin-1 on DNA synthesis in the myocardium of albino rats during early postnatal ontogeny.
Effect of intraperitoneal injection of endothelin-1 on DNA synthesis in the myocardium of newborn albino rats was studied by(3)H-thymidine autoradiography. Endothelin-1 injected in a single dose of 10 microg/kg stimulated proliferative processes: the index of labeled nuclei and labeling intensity increased. Repeated (5 times) administration of endothelin-1 in doses of 1 and 10 microg/kg increased labeling intensity, but did not change the index of labeled nuclei. The data suggest that endothelins are involved in morphogenesis of the myocardium during the early postnatal ontogeny.
Sazonova
E N
EN
Central Research Laboratory, Far-Eastern State Medical University, Khabarovsk.
Sazonov
O A
OA
Lebed'ko
O A
OA
Pikalova
V M
VM
Timoshin
S S
SS
Rubina
A Y
AY
D000818:Animals; D000831:Animals, Newborn; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D019332:Endothelin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000254:growth & development; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D013936:Thymidine / Q000378:metabolism
D019332:Endothelin-1; D004247:DNA; D013936:Thymidine