Early detection for lung cancer. New tools for casefinding.
OBJECTIVE
To review data from published population trials and clinical practice guidelines on screening for lung cancer to provide a recommendation for early detection of lung cancer.


METHODS
Literature was searched via MEDLINE using the MeSH headings "lung neoplasm," "mass screening," "thoracic radiography," and "sputum." Only prospective randomized controlled trials with large numbers of subjects were selected.


RESULTS
Risk of lung cancer among long-term heavy smokers continues even years after stopping smoking. Risk is highest in smokers with chronic obstructive pulmonary disease. Canadian clinical practice guidelines currently recommend that sputum cytology examination and chest radiography (CXR) not be used for lung cancer screening. This guideline was deducted from four randomized population trials in the 1970s that have serious limitations and applies to asymptomatic adults only. A CXR and sputum cytology examination are indicated in symptomatic current and former smokers older than 45 years with a smoking history of 30 pack-years or more and airflow obstruction defined as a forced expiratory volume in 1 second/forced vital capacity (FEV1/FVC) of 70% or less and a FEV1 lower than 70%. Curative treatment is available for early lung cancer. Substantial advances in innovative technologies for early detection using low-dose spiral CT and newer sputum tests have been made in the last three decades. Additional studies are under way to evaluate these new technologies.


CONCLUSIONS
Primary care physicians have an important role in identifying people at risk of developing lung cancer and in supporting research to evaluate new screening technology.
Lam
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Department of Medicine, University of British Columbia. sclam@interchange.ubc.ca
Lam
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Petty
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TL
D000367:Age Factors; D000465:Algorithms; D001707:Biopsy, Needle; D001999:Bronchoscopy; D002170:Canada; D003663:Decision Trees; D019317:Evidence-Based Medicine; D005194:Family Practice / Q000379:methods; D005541:Forced Expiratory Volume; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000209:etiology; D008403:Mass Screening / Q000379:methods* / Q000592:standards; D017410:Practice Guidelines as Topic; D013902:Radiography, Thoracic; D012107:Research Design; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects; D013147:Spirometry; D013183:Sputum / Q000166:cytology; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014797:Vital Capacity