The phenylacetyl-CoA catabolon: a complex catabolic unit with broad biotechnological applications.
The term catabolon was introduced to define a complex functional unit integrated by different catabolic pathways, which are, or could be, co-ordinately regulated, and that catalyses the transformation of structurally related compounds into a common catabolite. The phenylacetyl-CoA catabolon encompasses all the routes involved in the transformation of styrene, 2-phenylethylamine, trans-styrylacetic acid, phenylacetaldehyde, phenylacetic acid, phenylacetyl amides, phenylacetyl esters and n-phenylalkanoic acids containing an even number of carbon atoms, into phenylacetyl-CoA. This common intermediate is subsequently catabolized through a route of convergence, the phenylacetyl-CoA catabolon core, into general metabolites. The genetic organization of this central route, the biochemical significance of the whole functional unit and its broad biotechnological applications are discussed.
Luengo
J M
JM
Departamento de Bioquímica y Biología Molecular, Facultad de Veterinaria, Universidad de León, 24007 León, Spain. dbbjlr@unileon.es
García
J L
JL
Olivera
E R
ER
D000105:Acetyl Coenzyme A / Q000378:metabolism*; D001419:Bacteria / Q000235:genetics / Q000378:metabolism*; D001555:Benzene Derivatives / Q000378:metabolism; D001709:Biotechnology / Q000379:methods*; D001711:Biotransformation; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism; D005544:Forecasting; D010406:Penicillins / Q000096:biosynthesis; D010627:Phenethylamines / Q000378:metabolism; D010666:Phenylpropionates / Q000378:metabolism; D020058:Styrene / Q000378:metabolism
D001555:Benzene Derivatives; D005229:Fatty Acids, Monounsaturated; D010406:Penicillins; D010627:Phenethylamines; D010666:Phenylpropionates; C064180:4-phenyl-3-butenoic acid; C029261:phenethylamine; D020058:Styrene; D000105:Acetyl Coenzyme A; C037816:phenylacetyl-coenzyme A; C011377:tropic acid; C004912:ethylbenzene