Effect of different moisturizers on SLS-irritated human skin.
Moisturizers are widely used to treat irritant contact dermatitis (ICD). Their use is, however, not well-documented and standardized models for testing skin care products are needed to acquire documentation of their efficacy. The present study was undertaken to evaluate the effect of 6 commonly-used moisturizers on the recovery of irritated human skin. No commercial interests were involved in the study. 36 healthy volunteers had patch tests with SLS 0.5% applied on their forearms/upper arms for 24 h. After irritation of the skin, all volunteers had a moisturizer applied on one forearm/upper arm, respectively, 3 x daily for the following 5 days. The other forearm/upper arm served as an untreated control. Each moisturizer was tested on 12 volunteers and each volunteer tested 2 moisturizers at the same time. Evaluation was done on days 1, 3 and 8 by transepidermal water loss, electrical capacitance, laser Doppler flowmetry, DermaSpectrometry and clinical scoring. All 6 moisturizers were found to accelerate regeneration of the skin barrier function when compared to irritated non-treated skin. The most lipid-rich moisturizers improved barrier restoration more rapidly than the less lipid-rich moisturizers. We suggest this experimental model for further moisturizer efficacy testing.
Department of Dermatology, University of Copenhagen, Gentofte Hospital, Niels Andersensvej 65, 2900 Hellerup, Denmark.
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D003877:Dermatitis, Contact / Q000209:etiology / Q000517:prevention & control*; D004553:Electric Conductivity; D004643:Emollients / Q000494:pharmacology*; D004890:Erythema / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007509:Irritants / Q000009:adverse effects*; D008297:Male; D012039:Regional Blood Flow / Q000187:drug effects; D012720:Severity of Illness Index; D016037:Single-Blind Method; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects*; D014870:Water Loss, Insensible / Q000187:drug effects
D004643:Emollients; D007509:Irritants; D012967:Sodium Dodecyl Sulfate