Antibiotic resistance rates and macrolide resistance phenotypes of viridans group streptococci from the oropharynx of healthy Greek children.
A total of 200 isolates of viridans group streptococci isolated from the oropharynx of healthy Greek children were studied. Vancomycin, rifampicin, fluoroquinolones and dalfopristin/quinupristin were active against all tested isolates. High level resistance to gentamicin was not seen. Intermediate and high-level penicillin resistance was present in 28.5 and 14.5% isolates, respectively, with 41.3% of the latter group, being also resistant to cefotaxime. Resistance rates to other antimicrobials were as follows - erythromycin 38.5%, clarithromycin 33.5%, clindamycin 7.5% and tetracycline 23%. Penicillin resistance occurred more frequently in Streptococcus mitis isolates, while macrolide resistance was more frequent in S. oralis. MLSB resistance phenotype M was dominant (74%) among erythromycin resistant isolates, with phenotypes IR and CR being represented by 6 and 20% of isolates, respectively.
Department of Clinical Microbiology, P and A Kyriakou Childrens' Hospital, Thivon and Levadias 115 27, Athens, Greece. spyroslambrou@ath.forthnet.gr
S
S
Ioannidou
P T
PT
Tassios
A
A
Kotsovili-Tseleni
M
M
Foustoukou
N J
NJ
Legakis
A
A
Vatopoulos
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D000904:Antibiotics, Antitubercular / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D004352:Drug Resistance, Microbial / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D024841:Fluoroquinolones; D006115:Greece; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D009960:Oropharynx / Q000382:microbiology*; D010641:Phenotype; D012293:Rifampin / Q000494:pharmacology; D013291:Streptococcus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D013752:Tetracycline / Q000494:pharmacology; D014640:Vancomycin / Q000494:pharmacology; D014769:Virginiamycin / Q000031:analogs & derivatives* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000904:Antibiotics, Antitubercular; D024841:Fluoroquinolones; D014769:Virginiamycin; C113825:quinupristin; D002981:Clindamycin; D004917:Erythromycin; D014640:Vancomycin; D013752:Tetracycline; D017291:Clarithromycin; C113826:dalfopristin; D012293:Rifampin