Implications of oncogenomics for cancer research and clinical oncology.
The explosion of information generated by large-scale functional genomics technologies has resulted in an exponential increase in the number of potential genes and proteins available for pharmaceutical and diagnostic research development. In order to tap this potential, the primary challenge is to develop a strategy to effectively integrate and extract meaning from the human genomic sequence information that has been generated since the start of the Human Genome Project. This article deals with the strategies being applied by academics and by the biotechnology sector to sort and triage this information with the ultimate goal of identifying future therapeutic targets for cancer and other diseases.
Herrmann
J L
JL
Department of Internal Discovery, CuraGen Corporation, New Haven Connecticut 06511, USA.
Rastelli
L
L
Burgess
C E
CE
Fernandez
E E
EE
Rothberg
B E
BE
Rothberg
J M
JM
Shimkets
R A
RA
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D015195:Drug Design; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D015316:Genetic Therapy / Q000379:methods; D015894:Genome, Human; D006801:Humans; D016247:Information Storage and Retrieval / Q000379:methods; D008495:Medical Oncology; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D009857:Oncogenes; D010597:Pharmacogenetics / Q000379:methods*
D002273:Carcinogens