No effect of 50 Hz magnetic field observed in a pilot study on pentylenetetrazol-induced seizures and mortality in mice.
This study was planned so as to evaluate whether magnetic field exposure has any significant effect on the pentylenetetrazol (PTZ)-induced seizures. Mice were exposed to 50 Hz, 2 G (0.2 mT) magnetic field in glass cages for 1 h. Sham exposure was produced by turning off the current while the animals were in the same exposure volume. Then, PTZ was administered intraperitoneally (i.p.) at a dose of 60 mg/kg and the animals were observed for 30 min. Subsequently, the latency to seizure onset, total seizure duration, the number of seizure episodes and mortality were recorded for each subject. There was no evidence for a significant effect of the 50 Hz magnetic field on the mean number of PTZ induced seizures, seizure latency, total seizure duration and mortality (P>0.05). As a conclusion the present study failed to provide any further support for a therapeutic potential of magnetic field.
Keskil
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IS
Department of Neurosurgery, Fatih University Medical School, Ciftlik Caddesi No. 57, Emek, 06510, Ankara, Turkey. sk06-k@tr.net
Keskil
Z A
ZA
Canseven
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AG
Seyhan
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N
D000818:Animals; D003292:Convulsants; D004574:Electromagnetic Fields; D004829:Epilepsy, Generalized / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control; D005260:Female; D051379:Mice; D010433:Pentylenetetrazole; D010865:Pilot Projects
D003292:Convulsants; D010433:Pentylenetetrazole