Linking proteome and genome: how to identify parasite proteins.
Parasite genome projects are generating an avalanche of sequence data. If this resource is to be exploited effectively for drug and vaccine design, there is an urgent need to make the link between these DNA sequences and the functional proteins of the parasite, which they encode. Here, we seek to demystify the revolutionary advances in protein identification based on mass spectrometry.
Ashton
P D
PD
Dept. Biology, University of York, PO Box 373, YO10 5YW, York, UK. pda2@york.ac.uk
Curwen
R S
RS
Wilson
R A
RA
D000595:Amino Acid Sequence; D000818:Animals; D017178:Brugia malayi / Q000235:genetics; D016678:Genome; D018503:Genome, Protozoan; D015801:Helminth Proteins / Q000737:chemistry; D007891:Leishmania / Q000235:genetics; D013058:Mass Spectrometry / Q000379:methods; D008969:Molecular Sequence Data; D010751:Phosphopyruvate Hydratase / Q000737:chemistry; D010961:Plasmodium / Q000235:genetics; D020543:Proteome; D015800:Protozoan Proteins / Q000737:chemistry; D012550:Schistosoma mansoni / Q000235:genetics
D015801:Helminth Proteins; D020543:Proteome; D015800:Protozoan Proteins; D010751:Phosphopyruvate Hydratase