[Effect of lysophosphatidylcholine on the radiation-induced lipid peroxidation in liposomes].
The effect of lysophosphatidylcholine (LPC) on the lipid peroxidation process (LPO) in liposomes of rat liver phosphatidylcholine initiated by irradiation of 137Cs source was studied. The formation of diene conjugates (DC) is shown to increase dramatically on incorporation of more than 10% LPC into liposomes. The dependence of DC proportion on the irradiation dose is practically linear in the range of 0 to 5 kGy. The DC concentration in the liposomes without LPC grows at least to dose of 3.3 kGy and is unchanged on further irradiation. The malonic dialdehide accumulation follows the similar dependence. The LPC effect is neutralized by the incorporation of cholesterol into liposomes. The product of free radical fragmentation of LPC, palmitoxyacetone, practically has no influence on the DC concentration. The reasons of LPC effect on the irradiation initiated LPO in liposomes is discussed.
Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Minsk, 220141 Belarus. kisel@ns.iboch.ac.by
M A
MA
Kisel'
O I
OI
Shadyro
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IL
Iurkova
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D015227:Lipid Peroxidation / Q000528:radiation effects*; D008081:Liposomes / Q000378:metabolism* / Q000528:radiation effects*; D008244:Lysophosphatidylcholines / Q000378:metabolism* / Q000494:pharmacology; D051381:Rats
D008081:Liposomes; D008244:Lysophosphatidylcholines