Metabolism of fluorine-containing drugs.
This article reviews current knowledge of the metabolism of drugs that contain fluorine. The strategic value of fluorine substitution in drug design is discussed in terms of chemical structure and basic concepts in drug metabolism and drug toxicity.
Park
B K
BK
Department of Pharmacology and Therapeutics, New Medical Building, University of Liverpool, Liverpool, United Kingdom. bkpark@liverpool.ac.uk
Kitteringham
N R
NR
O'Neill
P M
PM
D000818:Animals; D017611:Fluorine Compounds / Q000737:chemistry / Q000378:metabolism* / Q000493:pharmacokinetics; D006801:Humans; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D014018:Tissue Distribution
D017611:Fluorine Compounds; D004364:Pharmaceutical Preparations