Studying experimental measles virus vaccines in the presence of maternal antibodies in the cotton rat model (Sigmodon hispidus).
The inhibition of vaccine-induced seroconversion after vaccination is one of the problems associated with measles virus (MV) immunization. In cotton rats, after transfer of human MV specific antibodies, vaccine-induced seroconversion is inhibited. With this model, it was shown that plasmid immunization (although successful in seronegative animals) was inhibited by maternal antibodies. In contrast, immunization via a mucosal surface with a vesicular stomatitis virus expressing the MV hemagglutinin induced seroconversion in the presence of maternal antibodies and subsequent protection.
Niewiesk
S
S
Institute of Virology and Immunobiology, University of Wuerzburg, Versbacher Str. 7, 97078, Wuerzburg, Germany. niewiesk@vim.uni-wuerzburg.de
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood*; D000918:Antibody Specificity; D004195:Disease Models, Animal; D005260:Female; D005822:Genetic Vectors; D006801:Humans; D007112:Immunity, Maternally-Acquired; D008457:Measles / Q000276:immunology / Q000517:prevention & control; D008458:Measles Vaccine / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D008459:Measles virus / Q000235:genetics / Q000276:immunology*; D011247:Pregnancy; D051381:Rats; D016205:Sigmodontinae; D019444:Vaccines, DNA / Q000235:genetics / Q000276:immunology / Q000494:pharmacology; D014721:Vesicular stomatitis Indiana virus / Q000235:genetics
D000914:Antibodies, Viral; D008458:Measles Vaccine; D019444:Vaccines, DNA