Successful combination chemotherapy (vincristine, procarbazine, etoposide, and prednisolone) in the treatment of inoperable, radioresistant low grade astrocytoma: a case report.
A case of successful combination chemotherapy using vincristine, procarbazine, VP-16 and prednisolone to treat an inoperable low grade astrocytoma is presented. This patient, whose tumor was also resistant to radiotherapy, had well controlled symptoms after the initiation of chemotherapy. A brain CT scan demonstrated disappearance of the tumor mass after eight courses of a combination chemotherapy regimen. She is at present symptom-free 80 months after diagnosis. This result suggests that combination chemotherapy may offer treatment modalities for low grade astrocytoma.
Maipang MVasiknanonte
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Department of Pediatrics, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand.
Janjindamai SHirunpat
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S
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001254:Astrocytoma / Q000188:drug therapy* / Q000532:radiotherapy; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D002648:Child; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
D011344:Procarbazine; D014750:Vincristine; D005047:Etoposide; D011239:Prednisolone