Sequence recognition of DNA by lexitropsins.
Lexitropsins are modular polyamide molecules that are designed to "read" the base sequence of DNA. Lexitropsins constructed of three types of subunits--pyrrole, imidazole and hydroxypyrrole--allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.
Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA 92037, USA. goodsell@scripps.edu
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D020029:Base Pairing; D018360:Crystallography, X-Ray; D004247:DNA / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D004214:Distamycins / Q000737:chemistry / Q000378:metabolism; D015195:Drug Design; D008956:Models, Chemical; D008958:Models, Molecular; D009429:Netropsin / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000378:metabolism* / Q000494:pharmacology
D004214:Distamycins; C053654:lexitropsin; D009429:Netropsin; C030000:stallimycin; D004247:DNA