[A study of the expression of c-myc onoprotein in laryngeal cancer and different distant adjacent mucosa].
Using citric-LSAB-microwave immunohistochemical technique, the expression of c-myc was studied in different regions of larynx including laryngeal squamous cell carcinoma (LSCC), border area, adjacent mucosa which was 0.5, 1.0, 1.5 and 2.0 cm away from cancer 30 cases and four cases of normal laryngeal mucosa. The results showed that over-expression of c-myc in LSCC was found in 29 of 30 (96.7%), which was higher than that in normal laryngeal mucosa (P < 0.01). A significant different expression of c-myc can be seen at the regions of 2.0 and 1.5 cm distant from the tumor (P < 0.05). The expression of c-myc increased as tissue progressed in sequence from normal mucosa, adjacent mucosa to carcinoma. The c-myc expression did not correlate with site of tumor, stage and histological grade (P > 0.05). The results indicate that over-expression of c-myc is involved in genesis of LSCC, and may be an early event in the development of human squamous-cell carcinoma of the larynx. The tissue adjacent to the tumor may have a potential malignancy.
Department of Otolaryngology, People's Hospital, Henan Province, Zhengzhou 450003.
B
B
Wan
M
M
Dong
Z
Z
Qin
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D016259:Genes, myc; D006801:Humans; D007820:Laryngeal Mucosa / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*
D016271:Proto-Oncogene Proteins c-myc