[The relationship between beta 3-adrenoceptor and regulation of body fat mass, and food intake].
beta 3-adrenoceptor(beta 3-AR) plays important roles in thermogenesis of brown adipose tissue(BAT) and lypolysis of white adipose tissue(WAT). Anti-obesity effect of beta 3-agonists is reported, and the Trp64Arg point mutation of the human beta 3-AR gene is associated with abdominal obesity. beta 3-agonist decreases food intake in rat and mice, and its effect is confirmed by both direct infusions to the brain and peripheral injections. Stimulated thermogenesis of BAT increases glucose utilization, then 'glucose dip' signals meal initiation. Risen core temperature leads to meal termination. But, because of decreased ability for thermogenesis, meal size increases in many obese animal models. Further investigations are being carried out to make these problems clear.
First Department of Internal Medicine, Kyoto Prefectural University of Medicine.
T
T
Yoshida
Y
Y
Takakura
N
N
Sakane
D000273:Adipose Tissue / Q000502:physiology*; D000818:Animals; D001069:Appetite Regulation / Q000502:physiology*; D006801:Humans; D051379:Mice; D051381:Rats; D022702:Receptors, Adrenergic, beta-3 / Q000502:physiology*
D022702:Receptors, Adrenergic, beta-3