Composing life.
Textbooks often assert that life began with specialized complex molecules, such as RNA, that are capable of making their own copies. This scenario has serious difficulties, but an alternative has remained elusive. Recent research and computer simulations have suggested that the first steps toward life may not have involved biopolymers. Rather, non-covalent protocellular assemblies, generated by catalyzed recruitment of diverse amphiphilic and hydrophobic compounds, could have constituted the first systems capable of information storage, inheritance and selection. A complex chain of evolutionary events, yet to be deciphered, could then have led to the common ancestors of today's free-living cells, and to the appearance of DNA, RNA and protein enzymes.
Department of Molecular Genetics and The Crown Human Genome Center, The Weizmann Institute of Science, Rehovot, Israel.
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D005075:Biological Evolution; D002384:Catalysis; D002455:Cell Division; D004247:DNA / Q000235:genetics / Q000378:metabolism; D016678:Genome; D050356:Lipid Metabolism; D008954:Models, Biological; D000069497:Origin of Life; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D012313:RNA / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D013501:Surface-Active Agents / Q000378:metabolism
D011506:Proteins; D013501:Surface-Active Agents; D012313:RNA; D004247:DNA