[Production of reactive nitrogen and oxygen intermediates in human granulocytes and monocytes during internalization of live BCG bacilli].
The production of nitric oxide (NO) and reactive oxygen intermediates in granulocytes and macrophages from healthy volunteers, infected in vitro with live Bacille Calmette-Guerin (BCG) mycobacteria, was estimated. Significant differences in the biochemical reactions induced by BCG bacilli in granulocytes and monocytes are described. The activity of phagocytes was also investigated in the cultures with cytokines: IFN-gamma, TNF-alpha, GM-CSF, IL-4.
Paziak-Domańska
B
B
Zakład Biologii Infekcyjnej Instytutu Mikrobiologii i Immunologii Uniwersytetu Łódzkiego.
Klink
M
M
Jurkiewicz
M
M
Rudnicka
W
W
D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology*; D009569:Nitric Oxide / Q000096:biosynthesis*; D010586:Phagocytes / Q000276:immunology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D012016:Reference Values
D016207:Cytokines; D017382:Reactive Oxygen Species; D009569:Nitric Oxide