title: Coprinol, a new antibiotic cuparane from a Coprinus species.
abstract: Coprinol, a new antibacterial cuparane, was isolated from fermentations of a Coprinus sp. Its biological activities were investigated and its structure was elucidated by spectroscopic methods. The new antibiotic exhibited activitiy against multidrug-resistant Gram-positive bacteria in vitro. Two derivatives were synthesized and their activities compared to the parent compound.
authors: Division of Organic Chemistry 2, Chemical Center, University of Lund, Sweden.
authors: M
authors: M
authors: Johansson
authors: O
authors: O
authors: Sterner
authors: H
authors: H
authors: Labischinski
authors: T
authors: T
authors: Anke
mesh_terms: D000230:Adenocarcinoma; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms; D003302:Coprinus / Q000737:chemistry*; D006801:Humans; D007939:Leukemia L1210; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D012717:Sesquiterpenes; C426845:coprinol