High resolution MAS-NMR in combinatorial chemistry.
High-resolution magic angle spinning (hr-MAS) NMR is a powerful tool for characterizing organic reactions on solid support. Because magic angle spinning reduces the line-broadening due to dipolar coupling and variations in bulk magnetic susceptibility, line widths approaching those obtained in solution-phase NMR can be obtained. The magic angle spinning method is amenable for use in conjunction with a variety of NMR-pulse sequences, making it possible to perform full-structure determinations and conformational analysis on compounds attached to a polymer support. Diffusion-weighted MAS-NMR methods such as SPEEDY (Spin-Echo-Enhanced Diffusion-Filtered Spectroscopy) can be used to remove unwanted signals from the solvent, residual reactants, and the polymer support from the MAS-NMR spectrum, leaving only those signals arising from the resin-bound product. This review will present the applications of high-resolution magic angle spinning NMR for use in combinatorial chemistry research.
Shapiro
M J
MJ
Core Technology Area /Analytics & Bio-NMR US Preclinical Research, Novartis Institute for Biomedical Research, Novartis Pharmaceuticals Corporation, Summit, New Jersey 07901, USA.
Gounarides
J S
JS
D020650:Combinatorial Chemistry Techniques; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008968:Molecular Conformation; D010455:Peptides / Q000737:chemistry; D012116:Resins, Plant
D010455:Peptides; D012116:Resins, Plant