Lipid domains in the endocytic pathway.
Whereas endosomes connect with both exocytic and endocytic organelle via extensive lipid and protein traffic, each endosome has a distinct lipid and protein composition. Recent observations suggest that different lipid membrane domains exist even in the same endosome. These lipid domains, together with low pH milieu, may present a variety of micro-environments to cargo molecules. Evidence is accumulating which suggests that the alteration of these lipid microdomains may be involved in a number of pathological conditions.
Kobayashi
T
T
Supra-Biomolecular System Research Group, RIKEN (Institute of Physical and Chemical Research), Frontier Research System, Wako-shi, Saitama 351-0198, Japan. kobayashi@postman.riken.go.jp
Yamaji-Hasegawa
A
A
Kiyokawa
E
E
D000818:Animals; D001693:Biological Transport, Active; D004705:Endocytosis / Q000502:physiology*; D011992:Endosomes / Q000378:metabolism / Q000502:physiology; D006801:Humans; D050356:Lipid Metabolism; D008055:Lipids / Q000502:physiology*; D021962:Membrane Microdomains / Q000502:physiology*
D008055:Lipids