Improved radiation hybrid map of rat chromosome 2: colocalization of the genes encoding corticotropin-releasing hormone and IL6-receptor with quantitative trait loci regulating the inflammatory response.
We established a radiation hybrid (RH) map of several genes and anonymous markers in the lower half of rat chromosome 2, a chromosome region that contains quantitative trait loci (QTLs) for blood pressure, diabetes and inflammatory response. Two of the newly localized genes (Crh and Il6r) encode proteins involved in the regulation of inflammatory and immune events. Our data show that they reside within regions that were genetically defined as QTLs controlling the inflammatory response. These genes are thus both functional and positional candidates.
Laes
J F
JF
Université Libre de Bruxelles, IBMM, Gosselies, Belgium.
Ravoet
M
M
Quan
X
X
Van Vooren
P
P
Szpirer
J
J
Szpirer
C
C
D000818:Animals; D003346:Corticotropin-Releasing Hormone / Q000235:genetics*; D005796:Genes; D005819:Genetic Markers; D017404:In Situ Hybridization, Fluorescence; D007249:Inflammation / Q000235:genetics*; D008126:Lod Score; D019655:Quantitative Trait, Heritable; D021101:Radiation Hybrid Mapping; D051381:Rats; D019947:Receptors, Interleukin-6 / Q000235:genetics*; D012984:Software
D005819:Genetic Markers; D019947:Receptors, Interleukin-6; D003346:Corticotropin-Releasing Hormone