Ring-deactivated hydroxymethylpyrroles as inhibitors of alpha-chymotrypsin.
N-Acyl and N-sulfonylhydroxymetyhylpyrroles have been synthesised and shown to inhibit alpha-chymotrypsin. A hydrophobic group in the N-substituent has been shown to be required for activity.
Abell
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AD
Department of Chemistry, University of Canterbury, Christchurch, New Zealand. a.abell@chem.canterbury.ac.nz
Nabbs
B K
BK
D000818:Animals; D002417:Cattle; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D007700:Kinetics; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D011758:Pyrroles; D015842:Serine Proteinase Inhibitors; D002918:Chymotrypsin; C117608:alpha-chymotrypsin