Acne with chronic recurrent multifocal osteomyelitis involving the mandible as part of the SAPHO syndrome: case report.
For 12 years, a 26-year-old man had acne conglobata and a non-suppurative diffuse sclerosing osteomyelitis of the mandible as part of a chronic recurrent multifocal osteomyelitis of the sternum, the pelvic bones, and the femoral head, and aseptic arthritis of the knee, the fibulotalar, and the sternoclavicular joints. This fulfills the formal criteria of the SAPHO syndrome. Repeated surgical and antibiotic treatment combined with hyperbaric oxygen caused partial improvement. Complete relief and partial disappearance of the scintigraphic lesions was achieved with long-term corticosteroids, non-steroidal anti-inflammatory drugs, minocycline, and isotretinoin.
Roldán
J C
JC
Department of Oral and Maxillofacial Surgery, Christian-Albrechts-Universität, Kiel, Germany. roldan@mkg.uni-kiel.de
Terheyden
H
H
Dunsche
A
A
Kampen
W U
WU
Schroeder
J O
JO
D000152:Acne Vulgaris / Q000188:drug therapy / Q000209:etiology*; D020083:Acquired Hyperostosis Syndrome / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D000328:Adult; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use; D008297:Male; D008336:Mandibular Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011239:Prednisolone / Q000627:therapeutic use; D011877:Radionuclide Imaging
D000893:Anti-Inflammatory Agents; D003879:Dermatologic Agents; D019980:Amoxicillin-Potassium Clavulanate Combination; D011239:Prednisolone; D015474:Isotretinoin