Type III export: new uses for an old pathway.
Gram-negative bacteria use type III secretion (TTS) systems to translocate proteins into the extracellular environment or directly into eukaryotic cells. These complex secretory systems are assembled from over 20 different structural proteins, including 10 that have counterparts in the flagellar export pathway. Secretion substrates are directed to the TTS machinery via mRNA and/or amino acid secretion signals. TTS chaperones bind to select secretion substrates and assist in the export process. Recent progress in the understanding of TTS is reviewed.
Plano
G V
GV
Department of Microbiology and Immunology, University of Miami School of Medicine, Miami, FL 33136, USA. gplano@med.miami.edu
Day
J B
JB
Ferracci
F
F
D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D005407:Flagella / Q000502:physiology; D006090:Gram-Negative Bacteria / Q000378:metabolism* / Q000472:pathogenicity; D021381:Protein Transport; D015398:Signal Transduction
D001425:Bacterial Outer Membrane Proteins; D002352:Carrier Proteins