Haliangicin, a novel antifungal metabolite produced by a marine myxobacterium. 1. Fermentation and biological characteristics.
Haliangicin, a novel beta-methoxyacrylate antibiotic with a conjugated tetraene moiety, was isolated from the culture broth of a marine myxobacterium. A bacterium tentatively named as Haliangium luteum required 2-3% NaCl for the growth and production of haliangicin. Haliangicin inhibits the growth of a wide spectrum of fungi but was inactive against bacteria. In mitochondrial respiratory chains, haliangicin interfered the electron flow within the cytochrome b-c1 segment.
Fudou
R
R
Central Research Laboratories, Ajinomoto Co, Inc, Kawasaki, Japan. ryosuke_fudou@ajinomoto.com
Iizuka
T
T
Yamanaka
S
S
D000935:Antifungal Agents / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D004579:Electron Transport / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D005285:Fermentation; D008386:Marine Biology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009243:NAD / Q000378:metabolism; D020560:Proteobacteria / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet
D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; C424925:haliangicin; D009243:NAD