[Effect of nitric oxide donors on myocardial contractile activity].
On the isolated guinea--pig heart perfused under Langendorff preparation influence of the NO was studied. Donators of NO were nitroglycerinum and sodium nitroprusside. The myocardium contractive activity indeces and the coronary flow were studied before and after introduction of the guanilatcyclase blockade by methylene blue. The received results show that after introduction of nitroglycerinum and sodium nitroprusside myocardium contractive activity indeces decrease, and the coronary flow increases. After introduction of methylene blue myocardium contractive activity indeces almost do not change--that confirms the guanilatcyclase mechanism of NO effect.
Lagodych
T S
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A. A. Bogomoletz National Medical University, Kiev.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D006162:Guanylate Cyclase / Q000378:metabolism; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology*; D009569:Nitric Oxide / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010477:Perfusion; D014665:Vasodilator Agents / Q000494:pharmacology*
D020030:Nitric Oxide Donors; D014665:Vasodilator Agents; D009599:Nitroprusside; D009569:Nitric Oxide; D006162:Guanylate Cyclase; D005996:Nitroglycerin