Highlights of human toxocariasis.
Human toxocariasis is a helminthozoonosis due to the migration of Toxocara species larvae through human organism. Humans become infected by ingesting either embryonated eggs from soil (geophagia, pica), dirty hands or raw vegetables, or larvae from undercooked giblets. The diagnosis relies upon sensitive immunological methods (ELISA or western-blot) which use Toxocara excretory-secretory antigens. Seroprevalence is high in developed countries, especially in rural areas, and also in some tropical islands. The clinical spectrum of the disease comprises four syndromes, namely visceral larva migrans, ocular larva migrans, and the more recently recognized "common" (in adults) and "covert" (in children) pictures. Therapy of ocular toxocariasis is primarily based upon corticosteroids use, when visceral larva migrans and few cases of common or covert toxocariasis can be treated by anthelmintics whose the most efficient appeared to be diethylcarbamazine. When diagnosed, all of these syndromes require thorough prevention of recontamination (especially by deworming pets) and sanitary education.
Magnaval
J F
JF
Service de Parasitologie, Centre Hospitalier Universitaire Rangueil 31403 Toulouse 4, France. magnaval@cict.fr
Glickman
L T
LT
Dorchies
P
P
Morassin
B
B
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use; D000909:Antibodies, Helminth / Q000097:blood; D015415:Biomarkers / Q000097:blood; D004049:Diethylcarbamazine / Q000627:therapeutic use; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood; D007816:Larva Migrans, Visceral / Q000175:diagnosis / Q000453:epidemiology; D014119:Toxocara / Q000276:immunology
D000871:Anthelmintics; D000909:Antibodies, Helminth; D015415:Biomarkers; D007073:Immunoglobulin E; D004049:Diethylcarbamazine