The influence of hypothermia on outer hair cells of the cochlea and its efferents.
Transient evoked otoacoustic emissions (TEOAE) were recorded in 21 guinea-pigs undergoing hypothermia. The minimal average body temperature during cooling was 26 degrees C/24.9 degrees C measured orally or rectally, respectively. The animals were subsequently warmed to normal body temperature. A clear influence of body temperature on TEOAE could be documented. During cooling the amplitude and reproducibilities decreased, disappearing completely at a mean temperature below 28.5 degrees C (oral) and 27.3 degrees C (rectal). The emissions reappeared during rewarming at a mean temperature of 30.1 degrees C (oral) and 30.8 degrees C (rectal). Contralateral auditory stimulation (CAS) led to a decrease of the amplitudes of TEOAE during cooling down to a mean of 33 degrees C/32 degrees C (oral/rectal temperature). During rewarming, influences of the CAS could be recognized, again at an oral temperature above 35 degrees C. The changes to the TEOAE observed in these experiments suggest that hypothermia affects not only the outer hair cells (OHC) of the cochlea but also the efferent supply to the cochlea.
Seifert
E
E
Department of Phoniatrics and Pedaudiology, Westphalian Wilhelms-University, Germany.
Brand
K
K
van de Flierdt
K
K
Hahn
M
M
Riebandt
M
M
Lamprecht-Dinnesen
A
A
D000161:Acoustic Stimulation / Q000379:methods; D000818:Animals; D001831:Body Temperature / Q000502:physiology; D003051:Cochlea / Q000378:metabolism* / Q000503:physiopathology*; D005260:Female; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000378:metabolism* / Q000503:physiopathology*; D007035:Hypothermia / Q000378:metabolism* / Q000503:physiopathology*; D008297:Male; D009476:Neurons, Efferent / Q000378:metabolism / Q000502:physiology*; D017084:Otoacoustic Emissions, Spontaneous / Q000502:physiology