Molecular analysis of implantation.
The great frontier in reproductive medicine is implantation biology. The scientific understanding of normal implantation lags behind what is known in areas such as fertilization. For obvious reasons this process is difficult to analyze. Recent investigations utilizing molecular biology approaches have scratched the surface of the interaction between the developing trophoblast and the receptive endometrium. This article describes these approaches with techniques such as serial analysis of gene expression (SAGE) and complementary DNA array hybridization, which will soon reveal the key mediators of normal implantation and result in an understanding of failed implantation.
Hines
R S
RS
Department of Obstetrics & Gynecology, University of Mississippi Medical Center, Jackson, Mississippi, USA.
D000818:Animals; D018920:Coculture Techniques; D010064:Embryo Implantation / Q000235:genetics*; D004717:Endometrium / Q000502:physiology; D005260:Female; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation; D005821:Genetic Techniques; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D011247:Pregnancy; D014327:Trophoblasts / Q000502:physiology
D006133:Growth Substances