[Surfactant--treatment of complete lobar atelectasis after exacerbation of bronchial asthma by infection].
Dysfunction of airway surfactant is suggested as an important factor contributing to the pathogenesis of bronchoconstriction of patients with asthma. We report the case of a 59-year-old female who had an infect-exacerbation of her asthma complicated by a complete collapse of the left lower lung lobe. Only the local application of 150 mg of bovine surfactant resulted in a complete reexpansion of the lobe. Local therapy with replacement of surfactant may be a promising therapeutic approach in treatment of forms of atelectasis, which depend on a dysfunction or disturbed homeostasis of surfactant.
Westhoff
M
M
Medizinische Klinik St. Elisabeth-Hospital Gütersloh-Pneumologie. WoelkeWesthoff@aol.com
Freitag
L
L
D000818:Animals; D001249:Asthma / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D001991:Bronchitis / Q000150:complications*; D002417:Cattle; D005260:Female; D006801:Humans; D007239:Infections / Q000150:complications*; D007322:Instillation, Drug; D008875:Middle Aged; D001261:Pulmonary Atelectasis / Q000188:drug therapy* / Q000209:etiology; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D011663:Pulmonary Surfactants