title: Neuropeptide Y and epilepsy: varying effects according to seizure type and receptor activation.
abstract: In vitro and in vivo experiments suggest antiepileptic properties for NPY. In this study, the pharmacology of these effects was examined and compared in different rat models of seizures. Agonists for Y(1), Y(2) and Y(5) receptors reduced seizure-like activity in hippocampal cultures. Intracerebral injection of NPY or Y(5) agonists reduced the expression of focal seizures produced by a single electrical stimulation of the hippocampus. Conversely, NPY agonists increased the duration of generalized convulsive seizures induced by pentylenetetrazol. These results suggest that NPY reduces seizures of hippocampal origin through activation of Y(5) receptors. They also point to probable modulatory effects of NPY in brain structures other than the hippocampus, involved in initiation, propagation or control of seizures.
authors: INSERM U398, Faculté de Médecine, 11 rue Humann, 67085, Strasbourg cedex, France. reibel@lyon151.inserm.fr
authors: S
authors: S
authors: Reibel
authors: S
authors: S
authors: Nadi
authors: R
authors: R
authors: Benmaamar
authors: Y
authors: Y
authors: Larmet
authors: J
authors: J
authors: Carnahan
authors: C
authors: C
authors: Marescaux
authors: A
authors: A
authors: Depaulis
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002478:Cells, Cultured; D004827:Epilepsy / Q000378:metabolism*; D006624:Hippocampus / Q000166:cytology / Q000378:metabolism; D008297:Male; D009478:Neuropeptide Y / Q000502:physiology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D017476:Receptors, Neuropeptide Y / Q000378:metabolism; D012640:Seizures / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D000927:Anticonvulsants; D009478:Neuropeptide Y; D017476:Receptors, Neuropeptide Y; C100568:neuropeptide Y5 receptor; D010433:Pentylenetetrazole