The influence of tibolone upon serum leptin levels in post-menopausal women.
OBJECTIVE
To estimate serum leptin levels in post-menopausal women, to relate these to the duration of the post-menopausal period, and to body mass index (BMI), and to assess the influence of tibolone on them.


METHODS
Fifteen women (age 49-64 years) were included. Three groups were studied; I, those with normal BMI taking tibolone; II, those with a raised BMI taking tibolone, and III, a group with raised BMI not taking tibolone. Blood samples were drawn before and 1, 2, 6, 9 and 12 months after the initiation of tibolone or, in group III, after the start of the study.


RESULTS
Serum leptin concentrations were high in all women with abnormal BMI. Long-term tibolone administration did not have any significant effect on serum leptin concentrations. There was no correlation between serum leptin levels and the age and the duration of post-menopausal period. There was a high positive correlation between serum leptin levels and BMI values.


CONCLUSIONS
BMI values affect serum leptin concentrations but long-term tibolone administration does not seem to have any effect on serum leptin levels.
Panidis
D K
DK
Division of Endocrinology and Human Reproduction, Third Department of Obstetrics and Gynecology, Aristotle University of Thessaloniki, 54623, Thessalonik, Greece.
Rousso
D H
DH
Kourtis
A I
AI
Stergiopoulos
K N
KN
Mavromatidis
G A
GA
Katsikis
I K
IK
D000367:Age Factors; D000368:Aged; D045930:Anabolic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006801:Humans; D020738:Leptin / Q000097:blood*; D008875:Middle Aged; D009652:Norpregnenes / Q000627:therapeutic use*; D017698:Postmenopause
D045930:Anabolic Agents; D020738:Leptin; D009652:Norpregnenes; C027385:tibolone