Combined pulmonary toxicity of cadmium chloride and sodium diethyldithiocarbamate.
The pulmonary toxicity of sodium diethyldithiocarbamate and cadmium chloride, each separately and in combination, was compared in Sprague-Dawley rats after single intratracheal instillation in sequential experiments by chemical, immunological and morphological methods. With combined exposure, the cadmium content of the lungs increased permanently relative to that of the lungs of just cadmium-treated animals. Immunoglobulin levels of the whole blood did not change, whereas in bronchoalveolar lavage the IgA and IgG levels increased significantly. Morphological changes were characteristic of the effects of cadmium but were more extensive and more serious than in the case of cadmium administration alone: by the end of the first month, interstitial fibrosis, emphysema and injury of membranes of type I pneumocytes developed and hypertrophy and loss of microvilli in type II pneumocytes were detectable. These results showed that although dithiocarbamates as chelating agents are suitable for the removal of cadmium from organisms, they alter the redistribution of cadmium within the organism, thereby increasing the cadmium content in the lungs, and structural changes are more serious than observed upon cadmium exposure alone.
Tátrai
E
E
National Institute of Occupational Health, Budapest, Hungary. tatray@elender.hu
Brózik
M
M
Náray
M
M
Adamis
Z
Z
Ungváry
G
G
D000818:Animals; D019256:Cadmium Chloride / Q000633:toxicity*; D002614:Chelating Agents / Q000493:pharmacokinetics / Q000633:toxicity*; D004050:Ditiocarb / Q000493:pharmacokinetics / Q000633:toxicity*; D004347:Drug Interactions; D004646:Emphysema / Q000139:chemically induced*; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002614:Chelating Agents; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D004050:Ditiocarb; D019256:Cadmium Chloride