Disease model: human aging.
Very little is known about the molecular mechanisms of human aging. This, at least in part, derives from a paucity of appropriate animal models of aging. Until recently, the senescence-accelerated mouse was the only mammalian model of aging. However, novel mouse models that exhibit multiple aging phenotypes have been developed in the past few years by disruption of the klotho gene, the telomerase gene and the genes involved in premature aging syndromes. These mouse models are expected to be important tools for aging research.
Kuro-o
M
M
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Blvd, Dallas, TX 75390-9072, USA. kuroo.makoto@pathology.swmed.edu
D000375:Aging; D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D004195:Disease Models, Animal; D005838:Genotype; D005966:Glucuronidase; D006801:Humans; D000090265:Klotho Proteins; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D010641:Phenotype; D011859:Radiography; D019098:Telomerase / Q000235:genetics
D008565:Membrane Proteins; D019098:Telomerase; D005966:Glucuronidase; D000090265:Klotho Proteins