title: Preliminary report: effect of adrenal androgen and estrogen on bone maturation and bone mineral density.
abstract: To clarify the independent physiological roles of adrenal androgen and estrogen on bone growth, we compared the lumbar spine bone mineral density (BMD) in prepubertal girls with virilizing congenital adrenal hyperplasia (CAH) (n = 17) and girls with central precocious puberty (CPP) (n = 18). When BMD was analyzed according to chronologic age, no significant differences were found between CPP and CAH patients. However, when adjusted to bone age, BMD was statistically higher in CAH than in CPP subjects. This finding suggests that adrenal androgen, as well as estrogen, plays an important role in increasing BMD. Adrenal androgen may act on bone not only as androgen, but as estrogen after having been metabolized into an aromatized bone-active compound in peripheral tissues, such as bone and fat. Therefore, adrenal androgen may have a more important role in increasing BMD than previously realized.
authors: Department of Pediatrics, Dokkyo University School of Medicine, Tochigi, Japan.
authors: O
authors: O
authors: Arisaka
authors: M
authors: M
authors: Hoshi
authors: S
authors: S
authors: Kanazawa
authors: M
authors: M
authors: Numata
authors: D
authors: D
authors: Nakajima
authors: S
authors: S
authors: Kanno
authors: M
authors: M
authors: Negishi
authors: K
authors: K
authors: Nishikura
authors: A
authors: A
authors: Nitta
authors: M
authors: M
authors: Imataka
authors: T
authors: T
authors: Kuribayashi
authors: K
authors: K
authors: Kano
mesh_terms: D015502:Absorptiometry, Photon; D000311:Adrenal Glands / Q000502:physiology*; D000312:Adrenal Hyperplasia, Congenital / Q000378:metabolism / Q000503:physiopathology; D000365:Age Determination by Skeleton; D000728:Androgens / Q000502:physiology*; D015519:Bone Density / Q000502:physiology*; D001846:Bone Development / Q000502:physiology*; D002648:Child; D004967:Estrogens / Q000502:physiology*; D005260:Female; D006801:Humans; D011629:Puberty, Precocious / Q000378:metabolism / Q000503:physiopathology
chemical_list: D000728:Androgens; D004967:Estrogens