title: Membranous glomerulonephritis in a patient with inherited activated protein C resistance.
abstract: We present a patient with membranous glomerulonephritis, several clinical complications of the antiphospholipid syndrome and ulcerative colitis, but without lupus anticoagulant and antiphospholipid/cofactor antibodies. Immunological studies--other antibodies--were negative and failed to show enough criteria for any autoimmune diseases. Evaluation of her laboratory tests for hereditary thrombophilia revealed a heterozygous form of the Leiden mutation that might be associated with widespread vasculopathy. An interesting possibility is that the inherited activated protein C resistance could be an additional risk factor for vaso-occlusive manifestations appearing as a clinical sign of cardiovascular diseases and nephropathy.
authors: 3rd Department of Internal Medicine, University Medical School, Debrecen, Hungary.
authors: N
authors: N
authors: Regéczy
authors: G
authors: G
authors: Lakos
authors: I
authors: I
authors: Balogh
authors: J
authors: J
authors: Kappelmayer
authors: E
authors: E
authors: Kiss
mesh_terms: D020016:Activated Protein C Resistance / Q000150:complications / Q000235:genetics*; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications*; D006801:Humans; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications