[Capsaicin-sensitive afferents in the vagus nerve].
Vanilloids were shown to interact with over 70% of vagal C-afferents first causing an excitation followed by desensitisation and a lasting destruction of nerve fibres. Capsaicin induces a secretion of some neuropeptides from 10-30% of vagal sensory terminals and therefore serves as a pharmacological tool for testing local "effector function" of primary afferents. Vagal afferents seem to have their own subtype of vanilloid receptors (VR), not completely identical with the VR receptors in the dorsal root ganglia. Considering potentiation of the capsaicin receptors sensitivity by some factors such as local heating, pH, free oxygen radicals, a possible role of the VRs as integrators of chemical and physical components of nociceptive stimuli, is discussed.
Zolotarev
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AD
I. P. Pavlov Institute of Physiology of the Russian Acad. Sci., 199034, St. Petersburg, Nab. Makarova, 6, Russia.
Nozdrachev
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D000344:Afferent Pathways / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D011955:Receptors, Drug / Q000502:physiology; D014630:Vagus Nerve / Q000187:drug effects* / Q000502:physiology; D014781:Viscera / Q000502:physiology
D011955:Receptors, Drug; D002211:Capsaicin