[Cyclooxygenases].
TWO ISOFORMS: There are two isoforms of cyclooxygenase (COX) with similar structure and metabolic activity. COX-1 is a constitutional enzyme. COX-2 is an inductible form. CYCLOOXYGENASE-1: COX-1 is present in most tissues, particularly in the kidney, the digestive tract mucosa, platelets, brain, liver and spleen. CYCLOOXYGENASE-2: COX-2 expression can be induced by an inflammatory process. Implicated in the development of certain cancers, COX-2 is expressed in numerous tumor cell lines and in most epithelial carcinomas. COX-2 favors tumor invasion and inhibits apoptosis. When it is absent, tumor growth is slower or stopped.
Eschwège
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Service d'Urologie, Hôpital de Bicêtre, 78, rue du Général Leclerc, F 94270 Le Kremlin-Bicêtre. peschwege@yahoo.com
de Ledinghen
V
V
Camilli
T
T
Kulkarni
S
S
Dalbagni
G
G
Droupy
S
S
Jardin
A
A
Benoît
G
G
Weksler
B B
BB
D017209:Apoptosis / Q000187:drug effects; D002277:Carcinoma / Q000201:enzymology / Q000503:physiopathology*; D002471:Cell Transformation, Neoplastic; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D008565:Membrane Proteins; D009361:Neoplasm Invasiveness; D009375:Neoplasms, Glandular and Epithelial / Q000201:enzymology / Q000503:physiopathology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D014407:Tumor Cells, Cultured
D007527:Isoenzymes; D008565:Membrane Proteins; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases