title: Transcription program of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus).
abstract: Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray containing nearly every known viral open reading frame. The patterns of viral gene expression offer insights into the replication and pathogenic strategies of HHV-8.
authors: HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
authors: M
authors: M
authors: Paulose-Murphy
authors: N K
authors: NK
authors: Ha
authors: C
authors: C
authors: Xiang
authors: Y
authors: Y
authors: Chen
authors: L
authors: L
authors: Gillim
authors: R
authors: R
authors: Yarchoan
authors: P
authors: P
authors: Meltzer
authors: M
authors: M
authors: Bittner
authors: J
authors: J
authors: Trent
authors: S
authors: S
authors: Zeichner
mesh_terms: D002460:Cell Line; D020869:Gene Expression Profiling; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D014158:Transcription, Genetic