Two consistently deleted regions within chromosome 1p32-pter in human non-small cell lung cancer.
Allelic losses at 1p32-pter have been reported as frequent events in human non-small cell lung cancer (NSCLC). To further characterize the region of deletions, we studied loss of heterozygosity on a panel of 102 microdissected NSCLC samples with 20 polymorphic markers spanning 1p32-pter. Two shortest regions of the overlap of the deletions (SROs) were found: SRO 2a (D1S417--D1S57) and SRO 2b (D1S450--D1S243). Allelic losses at either region correlated independently with advanced stage of disease and with postoperative metastasis and relapse (P < 0.05), suggesting that crucial genes in these regions are involved in NSCLC progression. Mol. Carcinog. 30:151--158, 2001.
Chizhikov
V
V
Oncogene Regulation Laboratory, NN Blokhin Cancer Research Center, Moscow, Russia.
Zborovskaya
I
I
Laktionov
K
K
Delektorskaya
V
V
Polotskii
B
B
Tatosyan
A
A
Gasparian
A
A
D002289:Carcinoma, Non-Small-Cell Lung / Q000235:genetics* / Q000401:mortality; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D019656:Loss of Heterozygosity; D008175:Lung Neoplasms / Q000235:genetics* / Q000401:mortality; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D018598:Minisatellite Repeats