Systemic Candida infection in University hospital 1997-1999: the distribution of Candida biotypes and antifungal susceptibility patterns.
A total of 102 Candida species were isolated from blood cultures from January 1997 to October 1999. Using assimilation of carbohydrate test, 52 (51.0%) of the Candida sp. were identified as C. parapsilosis, 25.5% (26) were C. tropicalis. C. albicans made up 11.8% (12), 6.9% (7) were C. rugosa, 3.8% (4) C. glabrata and 1% (1) C. guilliermondii. No C. dubliniensis was found in the study. In vitro antifungal susceptibility tests showed that all Candida species were sensitive to nystatin, amphotericin B and ketoconazole. Although all isolates remained sensitive to fluconazole, intermediate susceptibility was found in 3 C. rugosa isolates. Antifungal agents with high frequency of resistance were econazole, clotrimazole, miconazole and 5-fluorocytosine. Candida species found to have resistance to these antifungal agents were non-C. albicans.
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KP
Department of Medical Microbiology, Faculty of Medicine, University of Malaya, 50603 Kuala Lumpur, Malaysia. kpng@medicine.med.um.edu.my
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Soo-Hoo
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D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification* / Q000187:drug effects / Q000378:metabolism; D002177:Candidiasis / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D050260:Carbohydrate Metabolism; D003428:Cross Infection / Q000097:blood / Q000188:drug therapy / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D006785:Hospitals, University; D006801:Humans; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents