title: Amoebicidal and giardicidal compounds from the leaves of Zanthoxylum liebmannianun.
abstract: The crude ethanol extract from the leaves of Zanthoxylum liebmannianum exhibited inhibitory effect on the reproduction of trophozoites of Entamoeba histolytica (IC(50)=3.48 microg/ml) and Giardia lamblia (IC(50)=58.00 microg/ml). From this extract, asarinin, hyperin, beta-sitosterol, and beta-sitosterol glucoside were isolated. Among them, asarinin was the most active with IC(50) values of 19.86 microg/ml for E. histolytica and 35.45 microg/ml for G. lamblia. The remaining compounds showed moderate activity against both parasites.
authors: Facultad de Química, Departamento de Farmacia, Universidad Nacional Autónoma de México, Ciudad Universitaria, Coyoacán 04510, México D.F., Mexico.
authors: J
authors: J
authors: Arrieta
authors: B
authors: B
authors: Reyes
authors: F
authors: F
authors: Calzada
authors: R
authors: R
authors: Cedillo-Rivera
authors: A
authors: A
authors: Navarrete
mesh_terms: D000563:Amebicides / Q000494:pharmacology*; D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004748:Entamoeba histolytica / Q000187:drug effects*; D016829:Giardia lamblia / Q000187:drug effects*; D008519:Medicine, Traditional; D008800:Mexico; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D010946:Plants, Medicinal; D019685:Rosales
chemical_list: D000563:Amebicides; D000981:Antiprotozoal Agents; D010936:Plant Extracts