A new model for the origins of chronic disease.
Living things are often plastic during their early development and are moulded by the environment. Many human fetuses have to adapt to a limited supply of nutrients, and in doing so they permanently change their physiology and metabolism. These programmed changes may be the origins of a number of diseases in later life, including coronary heart disease, stroke, diabetes and hypertension.
Barker
D J
DJ
MRC Environmental Epidemiology Unit, Southampton General Hospital, Southampton, SO16 6YD, UK.
D015984:Causality; D002908:Chronic Disease; D003327:Coronary Disease / Q000209:etiology; D005314:Embryonic and Fetal Development / Q000502:physiology*; D005260:Female; D005826:Genetics, Medical; D006801:Humans; D008017:Life Expectancy; D008297:Male; D008954:Models, Biological; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D010927:Placental Insufficiency / Q000150:complications*; D011247:Pregnancy