title: Detection of clinically silent infarcts after carotid endarterectomy by use of diffusion-weighted imaging.
abstract: OBJECTIVE
  Intraprocedural transcranial Doppler sonography has identified multiple microembolic events during and immediately after carotid endarterectomy (CEA) or angioplasty, yet the rate of clinically evident stroke is small. To determine the significance of the transcranial Doppler sonography findings, we examined patients by use of diffusion-weighted imaging and fluid-attenuated inversion recovery MR imaging before and immediately after CEA for evidence of clinically silent ischemic events.
  
  
  METHODS
  Twenty-five patients with atherosclerotic disease of the carotid arteries underwent diffusion-weighted imaging and fluid-attenuated inversion recovery MR imaging performed, on average, 3 days before and 12 hours after CEA. Diffusion-weighted images were acquired in three orthogonal directions at b = 900. Pre- and postoperative neurologic examinations were performed by the same physician.
  
  
  RESULTS
  After endarterectomy, 4.0% of the patients (one of 25 patients) showed a single, cortical focus of restricted diffusion and new fluid-attenuated inversion recovery hyperintensity, measuring <1 cm in diameter, ipsilateral to the CEA. The postoperative neurologic examination showed no change in status from the preoperative baseline state. This patient had an intraoperative course complicated by the development of a large luminal thrombus, necessitating thrombectomy.
  
  
  CONCLUSIONS
  The use of diffusion-weighted imaging may serve to improve conspicuity of clinically silent infarcts after CEA. An important next step is to determine the risk factors that predispose to detectable parenchymal ischemic events.
authors: Department of Neurology, University of California, San Francisco 94143, USA.
authors: R J
authors: RJ
authors: Feiwell
authors: L
authors: L
authors: Besmertis
authors: R
authors: R
authors: Sarkar
authors: D A
authors: DA
authors: Saloner
authors: J H
authors: JH
authors: Rapp
mesh_terms: D000368:Aged; D002540:Cerebral Cortex / Q000473:pathology; D002544:Cerebral Infarction / Q000175:diagnosis*; D004058:Diffusion; D016894:Endarterectomy, Carotid; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D020244:Infarction, Middle Cerebral Artery / Q000175:diagnosis; D020766:Intracranial Embolism / Q000175:diagnosis; D007431:Intraoperative Complications / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D020768:Middle Cerebral Artery / Q000473:pathology; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000175:diagnosis*; D012680:Sensitivity and Specificity; D017585:Ultrasonography, Doppler, Transcranial