title: Changes in performance status of elderly patients after radiotherapy.
abstract: BACKGROUND
  To examine the feasibility of external radiation therapy for patients 80 years old and older.
  
  
  METHODS
  We analyzed changes in the performance status (PS) of 1353 patients by external radiotherapy at Osaka Teishin Hospital. In addition, factors influencing PS change and interruption of treatment were assessed in patients undergoing radical and palliative radiotherapy.
  
  
  RESULTS
  Among elderly patients aged 80 years or more (n=67), two patients showed deterioration in PS (3%), whereas 128 (10%) did so among those 79 years old or younger. The rate of treatment completion was 90% (60/67) for patients aged 80 years and over compared with 89% (1146/1286) for younger patients. Changes in PS were more frequent for palliative treatment (improvement 83/683, 12%; deterioration 77/683, 11%) than for radical treatment (improvement 12/305, 4%; deterioration 21/305, 7%) because patients with better performance status and early disease stages underwent radical treatment. For radical radiotherapy, patients with advanced disease (stages III and IV) showed more changes (improvement 4/108, 4%; deterioration 17/108, 16%) than those with early ones (stages I and II)(improvement 7/132, 5%; deterioration 3/132, 2%) (p<0.01). Better treatment results showed a higher treatment completion rate (CR 99%, PR 86%) than poor treatment results (NC 75%, PD 50%)(p<0.01). For palliative therapy, better performance status (PS 0-2) showed a better correlation with completion of treatment (403/451 or 89%) than did poor performance status (PS 3-4)(174/ 232, 75%)(p<0.01).
  
  
  CONCLUSIONS
  Age is not a limiting factor for external radiation therapy. Poor performance status is a significant predisposing factor for interruption of palliative radiotherapy.
authors: Department of Radiology, Toyonaka Municipal Hospital, Japan.
authors: H
authors: H
authors: Yamazaki
authors: T
authors: T
authors: Inoue
authors: K
authors: K
authors: Yoshida
authors: A
authors: A
authors: Imai
authors: Y
authors: Y
authors: Yoshioka
authors: E
authors: E
authors: Tanaka
authors: S
authors: S
authors: Shimamoto
authors: S
authors: S
authors: Nakamura
authors: Y
authors: Y
authors: Yamada
authors: H
authors: H
authors: Nakamura
authors: Y
authors: Y
authors: Araki
authors: T
authors: T
authors: Inoue
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006305:Health Status Indicators; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D011788:Quality of Life; D011878:Radiotherapy / Q000379:methods / Q000523:psychology*; D011879:Radiotherapy Dosage