Expression of Trk tyrosine kinase receptor is a biologic marker for cell proliferation and perineural invasion of human pancreatic ductal adenocarcinoma.
Pancreatic ductal adenocarcinoma (PDAC) is a widely known severe malignancy with a poor prognosis. Perineural invasion extending to the extra-pancreatic nerve plexus, a significant concern in the treatment is frequently present in this cancer. We analyzed immunohistochemical expression of neurotrophins (NGF, BDNF, NT-3) and the cognate receptors, Trk tyrosine kinase receptor family (TrkA, B, C) and p75NGFR in 28 surgically resected PDAC specimens. A comparative study between several clinicopathologic factors and Trk receptors revealed a significant correlation between increased expression of TrkA and cancer proliferation, as well as TrkC and cancer invasion, including venous and perineural invasion. The present findings revealed a novel mechanism in PDAC progression that is mediated via a NTs-Trk interaction.
Sakamoto
Y
Y
Department of Surgery, Saga Medical School, Saga 849-8501, Japan. dragonsakura@hotmail.com
Kitajima
Y
Y
Edakuni
G
G
Sasatomi
E
E
Mori
M
M
Kitahara
K
K
Miyazaki
K
K
D000230:Adenocarcinoma / Q000737:chemistry* / Q000473:pathology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis*; D019208:Brain-Derived Neurotrophic Factor / Q000032:analysis; D002455:Cell Division; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D019394:Ki-67 Antigen / Q000032:analysis; D018190:Neoplasm, Lymphatic Tissue; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic; D020933:Neurotrophin 3 / Q000032:analysis; D010183:Pancreatic Ducts; D010190:Pancreatic Neoplasms / Q000737:chemistry* / Q000473:pathology; D010524:Peripheral Nervous System Neoplasms / Q000737:chemistry* / Q000473:pathology; D011134:Polysaccharides / Q000032:analysis*; D020917:Receptor, trkA / Q000032:analysis*; D020813:Receptor, trkB / Q000032:analysis*; D020812:Receptor, trkC / Q000032:analysis*; D017475:Receptors, Nerve Growth Factor / Q000032:analysis
D014408:Biomarkers, Tumor; D019208:Brain-Derived Neurotrophic Factor; D019394:Ki-67 Antigen; D020933:Neurotrophin 3; D011134:Polysaccharides; D017475:Receptors, Nerve Growth Factor; C010491:neurotropin; D020917:Receptor, trkA; D020813:Receptor, trkB; D020812:Receptor, trkC