Development of high numbers of blood trypomastigotes of Trypanosoma cruzi in nude rats.
The development and pathogenicity of a Trypanosoma cruzi strain ("Chile 5") of low virulence were studied after infection of nude rats with different doses of blood trypomastigotes (10-10(7) parasites/rat). Peak parasitemias were correlated with the infection dose, which also influenced the mean survival times (26-36 days post-infection). Within 26 or 27 days, a subcutaneous injection of 10(7) blood trypomastigotes developed to about 8-20 x 10(7) parasites/ml.
Schaub
G A
GA
Department of Special Zoology, Ruhr University, Bochum, Germany. Guenter.A.Schaub@ruhr-uni-bochum.de
Hölscher
C
C
Mossmann
H
H
D000818:Animals; D014355:Chagas Disease / Q000097:blood / Q000276:immunology* / Q000635:transmission; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D016867:Immunocompromised Host; D018512:Parasitemia / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D011923:Rats, Nude; D014349:Trypanosoma cruzi / Q000254:growth & development / Q000276:immunology* / Q000472:pathogenicity