title: Assessing aggregate and cumulative pesticide risks using a probabilistic model.
abstract: Determining aggregate and cumulative risks from exposures to pesticides presents a number of challenges. The analysis must capture the correlations in residues that occur from both additive and exclusionary processes in the use of pesticides. The analysis also requires a quantitative mechanism for evaluating risks associated with exposures to mixtures of pesticides. This paper presents an analysis of aggregate exposures and risks associated with exposures to a pesticide, Alpha, and the cumulative exposure to and risk from three pesticides, Alpha, Beta, and Gamma. The cumulative risks are evaluated by determining the systemic (absorbed) doses that result from inhalation, dermal, and oral exposures to the pesticides. A 'relative toxicity' model is used to evaluate cumulative risks. The assessment of cumulative exposure was performed using the LifeLine Version 1.0. The model simulates pesticide exposure using an individual-based approach where daily exposures are evaluated for each person, season, and location.
authors: The LifeLine Group, Cape Elizabeth, ME 04107, USA. psprice@pipeline.com
authors: P S
authors: PS
authors: Price
authors: J S
authors: JS
authors: Young
authors: C F
authors: CF
authors: Chaisson
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D004781:Environmental Exposure; D006801:Humans; D019570:Inhalation Exposure; D015233:Models, Statistical; D010573:Pesticide Residues; D010575:Pesticides / Q000009:adverse effects*; D018570:Risk Assessment
chemical_list: D010573:Pesticide Residues; D010575:Pesticides