The role of molecules that mediate apoptosis in T-cell selection.
The T-cell repertoire is generated as a result of selection processes that happen in the thymus. The molecular basis of these processes is beginning to be elucidated and many of the molecules identified have a role in regulating cell death. These molecules range from orphan nuclear receptors and transcription factors to cyclin-dependent kinase 2 and Bcl2 family members.
Williams
O
O
Division of Molecular Immunology, National Institute for Medical Research, The Ridgeway, Mill Hill, NW7 1AA, London, UK.
Brady
H J
HJ
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D017637:Clonal Deletion; D004268:DNA-Binding Proteins / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology* / Q000276:immunology*; D014157:Transcription Factors / Q000502:physiology*
D004268:DNA-Binding Proteins; D014157:Transcription Factors