Modulating the immune response with dendritic cells and their growth factors.
Different subsets of dendritic cells (DCs) appear to play a role in determining the specific cytokines secreted by T helper (Th) cells. A model is proposed that links together factors such as the pathogen, microenvironment, DCs and T cells in a mechanism that results in a flexible determination of T-cell polarization.
Pulendran
B
B
Baylor Institute for Immunology, Dallas, TX 75204, USA. balip@baylordallas.edu
Banchereau
J
J
Maraskovsky
E
E
Maliszewski
C
C
D000276:Adjuvants, Immunologic / Q000502:physiology*; D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D019070:Cell Lineage / Q000276:immunology; D003713:Dendritic Cells / Q000145:classification / Q000166:cytology / Q000276:immunology*; D006133:Growth Substances / Q000276:immunology*; D006801:Humans
D000276:Adjuvants, Immunologic; D006133:Growth Substances