Subarachnoid hemorrhage associated with cyclosporine A neurotoxicity in a bone-marrow transplant recipient.
We report subarachnoid hemorrhage associated with cyclosporine A (CSA) neurotoxicity after bone-marrow transplantation for chronic myelogenous leukemia. CT showed occipital subarachnoid hemorrhage. MRI confirmed this, and demonstrated cortical and subcortical edema in the posterior temporal, occipital, and posterior frontal lobes bilaterally, which was typical of CSA neurotoxicity. Recognition of CSA neurotoxicity as the cause of the subarachnoid hemorrhage obviated angiographic investigation. After cessation of cyclosporine therapy, the cortical and subcortical edema resolved on follow-up MRI with some residual blood products in the subarachnoid space.
Teksam
M
M
Department of Radiology, University of Minnesota Medical School, Minneapolis, USA.
Casey
S O
SO
Michel
E
E
Truwit
C L
CL
D000328:Adult; D016026:Bone Marrow Transplantation; D001929:Brain Edema / Q000209:etiology; D002533:Cerebral Angiography; D016572:Cyclosporine / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008279:Magnetic Resonance Imaging; D013345:Subarachnoid Hemorrhage / Q000139:chemically induced* / Q000473:pathology
D007166:Immunosuppressive Agents; D016572:Cyclosporine