A comparison of the effects of sarin and succinylcholine on respiratory parameters in anesthetized domestic swine.
Differences in the "respiratory paralysis" caused by sarin (GB) and succinylcholine (SDC) were observed in a domestic swine model using a bedside pulmonary dynamics monitor. GB was administered intravenously (9 micrograms/kg/30 min) and compared with SDC administered intravenously (20 mg/30 min). All animals developed respiratory insufficiency indicated by decreased respiratory frequency. Minute ventilation was relatively maintained in animals that received GB by increasing tidal volume, whereas both of these parameters decreased in animals that received SDC. GB animals showed an increase in airway resistance and work of breathing. The former was unchanged and the latter was decreased in animals that received SDC. Mouth occlusion pressure at 100 milliseconds and tidal volume were relatively maintained in GB animals but decreased in SDC animals, suggesting a central mechanism for respiratory paralysis with GB and a peripheral mechanism for respiratory paralysis with SDC.
Duncan
E J
EJ
Kinchyle Enterprises, Inc., Medicine Hat, Alberta, Canada T1A 7M6.
Conley
J D
JD
Grychowski
K D
KD
Conley
S A
SA
Lundy
P M
PM
Hamilton
M G
MG
Sawyer
T W
TW
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D002619:Chemical Warfare Agents / Q000633:toxicity*; D008297:Male; D009467:Neuromuscular Depolarizing Agents / Q000633:toxicity*; D015656:Respiratory Mechanics / Q000187:drug effects; D012133:Respiratory Paralysis / Q000139:chemically induced / Q000503:physiopathology*; D012524:Sarin / Q000633:toxicity*; D013390:Succinylcholine / Q000633:toxicity*; D013552:Swine
D002619:Chemical Warfare Agents; D009467:Neuromuscular Depolarizing Agents; D012524:Sarin; D000110:Acetylcholinesterase; D013390:Succinylcholine