A comment on optimal allocations for bioequivalence studies.
A method purporting to provide optimal allocations in bioequivalence studies fails to do so on both statistical and practical grounds. Reasons as to why this is so are given.
Senn
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Department of Epidemiology and Public Health, University College London, UK. stephens@public.health.ucl.ac.uk
Grieve
A P
AP
D001699:Biometry; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D018592:Cross-Over Studies; D003627:Data Interpretation, Statistical; D006801:Humans; D013810:Therapeutic Equivalency