Analgesic-induced asthma caused by 2.0% ketoprofen adhesive agents, but not by 0.3% agents.
A 74-year-old woman was admitted with an asthma attack. She had a 40-year history of sinusitis, nasal polyp and analgesic-induced asthma; however, asthma had never occurred when she used a 0.3% ketoprofen adhesive patch (Mohrus) for stiff shoulder or lumbago. In the hospital, a life-threatening asthma attack suddenly occurred two and a half hours after application of a 2.0% ketoprofen adhesive tape (Mohrus tape) to her shoulder. She was treated with bronchodilator and glucocorticoid and extubated after 20 hours. A drug lymphocyte stimulating test (DLST) was strongly positive for ketoprofen. We suspected that drug-induced hypersensitivity coexisted in the present case, but it was not clear whether or not the hypersensitivity was related to the pathogenesis of analgesic-induced asthma.
Kashiwabara
K
K
Respiratory Department, Taragi Municipal Hospital, Kumamoto.
Nakamura
H
H
D000269:Adhesives; D000279:Administration, Cutaneous; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D001577:Benzophenones / Q000008:administration & dosage / Q000009:adverse effects; D003128:Coma / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000009:adverse effects*; D017116:Low Back Pain / Q000188:drug therapy; D008213:Lymphocyte Activation / Q000187:drug effects; D012116:Resins, Plant; D020069:Shoulder Pain / Q000188:drug therapy
D000269:Adhesives; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001577:Benzophenones; D012116:Resins, Plant; D007660:Ketoprofen; C005290:oxybenzone