Visceral leishmaniasis in an AIDS patient on successful antiretroviral therapy: failure of parasite eradication despite increase in CD4+ T-cell count but low CD8+ T-cell count.
An unusual cutaneous relapse of visceral leishmaniasis (initially mistaken for eruptive histiocytomas) was seen in an AIDS patient despite good virological and CD4+ T-cell responses to highly active antiretroviral therapy. Splenectomy and the patient's low CD8+ T-cell count are discussed as possible causes of failed disease control.
Petter
A
A
Department of Dermatology, University of Innsbruck, Austria.
Shetty-Lee
A
A
Kofler
G
G
Huemer
H P
HP
Larcher
C
C
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000469:parasitology*; D000328:Adult; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D018414:CD8-Positive T-Lymphocytes; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy*; D002836:Hemophilia B / Q000150:complications; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000188:drug therapy / Q000209:etiology*; D012008:Recurrence; D013156:Splenectomy; D017211:Treatment Failure