title: Pathophysiology and treatment of secondary obsessive-compulsive behaviors and tics.
abstract: Advances in neurobiological research suggest that certain frontal-subcortical circuits play important roles in idiopathic obsessive-compulsive disorder and Tourette's syndrome. Tics and obsessive-compulsive behaviors secondary to neurologic insult appear to involve the same neural circuitry. There are few systematic studies of the treatment of obsessive-compulsive behaviors and tics associated with neurologic disorders. However knowledge of the circuitry and associated neurochemistry of these disorders can help to outline a rational approach to these behaviors.
authors: Pediatric and Developmental Neuropsychiatry Branch, National Institute of Mental Health, 10 Center Drive, Building 10 Room 4N-208, Bethesda, MD 20892, USA.
authors: R K
authors: RK
authors: Bhangoo
mesh_terms: D017109:Akathisia, Drug-Induced / Q000517:prevention & control; D001479:Basal Ganglia / Q000503:physiopathology; D001480:Basal Ganglia Diseases / Q000150:complications / Q000503:physiopathology; D006801:Humans; D009434:Neural Pathways / Q000503:physiopathology; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology*; D017397:Prefrontal Cortex / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D020323:Tics / Q000209:etiology*; D005879:Tourette Syndrome / Q000188:drug therapy / Q000503:physiopathology
chemical_list: D018377:Neurotransmitter Agents; D011619:Psychotropic Drugs