Experimentally induced cholangiohepatopathy by dosing sheep with fractionated extracts from Brachiaria decumbens.
Cholangiohepatopathy was induced in 5 lambs by oral administration of extracts from signal grass (Brachiaria decumbens) in Brazil. Grossly there were pale foci multifocally distributed throughout the hepatic parenchyma in 4 lambs. The microscopic changes, which were similar to those produced by other steroidal sapogenins-containing plants such as Tribulus terrestris and Panicum spp., included multifocal cholangitis, bile duct proliferation, and the presence of crystals in the biliary system.
Cruz
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Department of Veterinary Pathology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Driemeier
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D
Pires
V S
VS
Schenkel
E P
EP
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D056486:Chemical and Drug Induced Liver Injury; D008107:Liver Diseases / Q000473:pathology / Q000662:veterinary*; D008897:Panicum; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000662:veterinary*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D006109:Poaceae; D012756:Sheep; D012757:Sheep Diseases / Q000473:pathology*
D010936:Plant Extracts