title: [Central nervous system tuberculosis in children: 1. Clinical and laboratorial presentation].
abstract: Tuberculosis still occupies a remarkable place as a worldwide health problem, chiefly in emerging countries, like Brazil. The central nervous system (CNS) involvement by Mycobacterium tuberculosis is one of the most feared features of disease, because of its high morbidity and mortality. This study aimed to describe some epidemiological, clinical and laboratorial aspects of 52 children in a tertiary pediatric hospital with CNS tuberculosis. At diagnosis, the majority of patients showed low age, compromised nutritional status, previous contact with bacillary individuals, delayed or absent immunization, advanced neurological signs and compatible abnormalities in cerebrospinal fluid (CSF) analysis and in radiological findings. The etiologic agent was identified by staining methods or CSF and other fluids culturing in 40% of patients. In most cases, despite of suggestive clinical, epidemiological and laboratorial picture and feasibility of patients access to health care centres, therapy was started late.
authors: Unidade de Neurologia, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo.
authors: F A
authors: FA
authors: Gusmão Filho
authors: H H
authors: HH
authors: Marques
authors: M J
authors: MJ
authors: Marques-Dias
authors: S R
authors: SR
authors: Ramos
mesh_terms: D000293:Adolescent; D001938:Brazil / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D020306:Tuberculosis, Central Nervous System / Q000175:diagnosis / Q000453:epidemiology* / Q000382:microbiology