title: [Giant-cell reaction in the breast after fine-needle aspiration].
abstract: We report two cases in which fine needle aspiration (FNA) in the breast generated changes histologically mimicking malignant lesions. In both cases a population of giant cells was present; the cells were osteoclast-like in the first case and 'atypical' multinucleated stromal giant cells in the second. The underlying lesion was pseudoangiomatous stromal hyperplasia (PASH) in both cases. The reactive nature was confirmed by retracing the needle tract and by the uneventful follow-up of 7 or 2 years, respectively. We propose that giant cell reaction be included in the list of FNA-generated changes.
authors: Dipartimento di Oncologia, Sezione di Anatomia, Istologia e Citologica Patologica M. Malpighi, Università di Bologna, Ospedale Bellaria, Via Altura 3, I-40139 Bologna.
authors: G
authors: G
authors: Marucci
authors: A
authors: A
authors: Bondi
authors: P
authors: P
authors: Lorenzini
authors: V
authors: V
authors: Eusebi
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle / Q000009:adverse effects*; D001940:Breast / Q000737:chemistry / Q000293:injuries* / Q000473:pathology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D003951:Diagnostic Errors; D005260:Female; D018226:Fibroadenoma / Q000175:diagnosis / Q000473:pathology; D015726:Giant Cells / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D018219:Histiocytoma, Benign Fibrous / Q000175:diagnosis; D006801:Humans; D008197:Lymph Node Excision; D015412:Mastectomy, Segmental; D008413:Mastitis / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged
chemical_list: D014408:Biomarkers, Tumor