Anti-Yo-associated paraneoplastic cerebellar degeneration in a man with gastric adenocarcinoma.
Paraneoplastic cerebellar degeneration (PCD) with anti-Yo antibodies is almost always associated with ovarian and breast cancer. We describe a man with anti-Yo-positive PCD and gastric adenocarcinoma. The tumor cells were labeled with anti-Yo antibodies by immunohistochemistry. High serum titers of anti-Yo antibodies were found before surgery and decreased 6 months after resection of the tumor. The expression of Yo antigens by the tumor and the decrease in anti-Yo antibody titers after its removal suggest that the immune response against the Purkinje cells of the cerebellum was triggered by the tumor.
Meglic
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B
Department of Neurology, University Medical Centre, Zaloska 7, 1525, Ljubljana, Slovenia. Bernard.Meglic@kclj.si
Graus
F
F
Grad
A
A
D000230:Adenocarcinoma / Q000097:blood / Q000150:complications* / Q000276:immunology; D000368:Aged; D000906:Antibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens; D002531:Cerebellum / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D004268:DNA-Binding Proteins / Q000097:blood / Q000276:immunology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood / Q000276:immunology*; D009410:Nerve Degeneration / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D009419:Nerve Tissue Proteins; D020362:Paraneoplastic Cerebellar Degeneration / Q000097:blood / Q000209:etiology* / Q000276:immunology; D011689:Purkinje Cells / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D013274:Stomach Neoplasms / Q000097:blood / Q000150:complications* / Q000276:immunology
D000906:Antibodies; D001324:Autoantigens; C063762:CDR1 protein, human; C095184:CDR2 protein, human; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins