title: Relationships between personality disorders and anthropometry, hormones and metabolism in women.
abstract: This study sought to examine the potential influence of personality disorders (PD) on anthropometry, hormones and metabolism in women. In a population sample of women born in 1956 (no.=270), estimates of PD:s by Structured Clinical Interview for DSM-III-R, Axis II, were correlated with anthropometric, endocrine, and metabolic factors. The PD:s were grouped into three thematic clusters: cluster A (characterized by oddness or eccentricity), cluster B (characterized by self-centeredness, emotionality, and erratic behavior) and cluster C (characterized by anxiety and fear). Subjects with cluster A PD:s had significantly increased body mass index (BMI, kg/m2) and abdominal sagittal diameter (cm) as well as lower salivary cortisol after dexamethasone (DEX) compared to controls. Subjects with cluster B also had a significantly higher abdominal sagittal diameter and significantly lower salivary cortisol levels after DEX than controls. In addition, subjects with cluster B PD:s had decreased levels of ACTH, and significantly higher concentrations of lactate and triglycerides, while high-density lipoprotein (HDL) cholesterol was significantly lower compared to controls. A significantly higher waist/hip ratio was seen among subjects with cluster C PD:s. In addition, these subjects had higher levels of insulin, glucose, lactate, triglycerides, total cholesterol and low-density lipoprotein (LDL) cholesterol than controls. Moreover, IGF-I and HDL cholesterol were significantly decreased in the former group. These results suggest that PD:s are involved in the development of obesity and abdominal fat accumulation in women, with different endocrine and metabolic profiles depending on the type of PD.
authors: Department of Heart and Lung Diseases, Göteborg University, Sahlgrenska University Hospital, Sweden.
authors: R
authors: R
authors: Rosmond
authors: F
authors: F
authors: Baghei
authors: G
authors: G
authors: Holm
authors: P
authors: P
authors: Björntorp
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D000342:Affective Symptoms / Q000503:physiopathology; D000886:Anthropometry; D001007:Anxiety / Q000503:physiopathology; D001786:Blood Glucose / Q000032:analysis; D001824:Body Constitution; D015992:Body Mass Index; D008076:Cholesterol, HDL / Q000097:blood; D003907:Dexamethasone; D005239:Fear; D005260:Female; D005938:Glucocorticoids; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000032:analysis; D007328:Insulin / Q000097:blood; D019344:Lactic Acid / Q000097:blood; D009765:Obesity / Q000209:etiology; D010554:Personality Disorders / Q000378:metabolism / Q000503:physiopathology*; D012463:Saliva / Q000737:chemistry; D014280:Triglycerides / Q000097:blood
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D005938:Glucocorticoids; D006728:Hormones; D007328:Insulin; D014280:Triglycerides; D019344:Lactic Acid; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone