Cyclotron production of 67Ga(III) with a tandem natGe-natZn target.
Production of 67Ga(III) at the National Accelerator Centre is by proton bombardment of a natZn target, and uses 15-20 h of cyclotron beam time per production. A study was undertaken to use a tandem natGe-natZn target to produce the same amount of 67Ga, but using less beam time (7-8 h). 67Ga(III) was separated from the tandem target material by a method based on acid dissolution of the target and chromatography on an organic polymer resin (Amberchrom CG-71cd) containing no ion exchange groups. The separated 67Ga(III) has high radionuclidic purity and complies with the British and US Pharmacopoeia requirements for chemical purity.
Naidoo
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National Accelerator Centre, Faure, South Africa. naidoo@nac.ac.za
van der Walt
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TN
D002138:Calibration; D017357:Cyclotrons; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D005857:Germanium; D006801:Humans; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D015032:Zinc
D005710:Gallium Radioisotopes; D019275:Radiopharmaceuticals; D005857:Germanium; D015032:Zinc