Interaction of microcrystalline cellulose and water in granules prepared by a high-shear mixer.
Microcrystalline cellulose (MCC) granules were prepared by wet granulation using a high-shear mixer. Physical characteristics of the granules were investigated using near IR spectrometry, thermogravimetry and isothermal water vapor adsorption. Near IR spectra of dried MCC granules prepared for various granulation times exhibited different peak intensities at 1428, 1772, and 1920 nm, which were assigned to functional groups of cellulose or water. On isothermogravimetric analysis, the rate of dehydration of water was shown to decrease with granulation time. These results suggest that the physical structure of MCC could change during the granulation process, and the interaction between MCC and water was gradually strengthened. The isothermal water vapor adsorption curves suggested that the amorphous region of MCC would be divided by the strong shear force of the impeller, because the high adsorption ability of intact MCC in the low humidity region was diminished in granules collected following 5 and 10 min of granulation. It was suggested that MCC formed a network which caught water within its structure during the wet granulation process.
Suzuki
T
T
Pharmaceutical Technology Research Laboratories, Daiichi Pharmaceutical Co., Ltd., Tokyo, Japan. suzuk87c@daiichipharm.co.jp
Kikuchi
H
H
Yonemochi
E
E
Terada
K
K
Yamamoto
K
K
D002482:Cellulose / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004339:Drug Compounding; D004574:Electromagnetic Fields; D005079:Excipients; D006813:Humidity; D010316:Particle Size; D011208:Powders; D013055:Spectrophotometry, Infrared; D013818:Thermogravimetry; D014867:Water / Q000737:chemistry
D005079:Excipients; D011208:Powders; D014867:Water; D002482:Cellulose; C109691:microcrystalline cellulose