Cranial reossification with absorbable plates.
The purpose of this study was to examine the effect of Lactosorb absorbable plates on bone healing across cranial bone defects in the rabbit skull. Two 10-mm diameter parietal skull defects were created in each of 20 rabbits, with one defect being placed on either side of the sagittal suture. In 10 rabbits, an absorbable plate was placed across both the inner and outer cortices of the left defect, and in the other 10 rabbits, an absorbable plate was placed across the outer cortex only of the left defect. The right defect always served as the control side, with no plate being placed across it. Rabbits were killed an average of 25 weeks postoperatively. Areas of reossification in the experimental and control defects of each rabbit were then measured, examined histologically, and compared. Growth across defects spanned by one plate was also compared with growth across defects spanned by two plates. Histologic and statistical analyses revealed no significant differences in reossification between the control and experimental defects in each animal and between the defects spanned by one versus two plates. This study suggests that these copolymer absorbable plates neither inhibit nor facilitate reossification across 10-mm diameter rabbit cranial defects.
Ascherman
J
J
Department of Surgery, Division of Plastic Surgery, at the Columbia-Presbyterian Medical Center, Columbia University College of Physicians and Surgeons, New York, NY, USA. jaa7@columbia.edu
Knowles
S
S
Marin
V
V
Prisant
N
N
Hu
G
G
Chiu
D T
DT
D020341:Absorbable Implants; D000818:Animals; D001860:Bone Plates; D001861:Bone Regeneration; D016348:Osseointegration; D011817:Rabbits; D012886:Skull / Q000166:cytology / Q000601:surgery*; D014945:Wound Healing