Pneumolysin potentiates production of prostaglandin E(2) and leukotriene B(4) by human neutrophils.
Exposure to pneumolysin (8.37 and 41.75 ng/ml) caused a calcium-dependent increase in the generation of prostaglandin E(2) and leukotriene B(4) by both resting and chemoattractant-activated human neutrophils in vitro. These interactions of pneumolysin with neutrophils may result in dysregulation of inflammatory responses during pneumococcal infection.
Cockeran
R
R
Medical Research Council Unit for Inflammation and Immunity, Department of Immunology, Institute for Pathology, University of Pretoria, Pretoria, South Africa. rcockera@postillion.up.ac.za
Steel
H C
HC
Mitchell
T J
TJ
Feldman
C
C
Anderson
R
R
D000328:Adult; D001426:Bacterial Proteins; D015232:Dinoprostone / Q000096:biosynthesis*; D006801:Humans; D007975:Leukotriene B4 / Q000096:biosynthesis*; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000378:metabolism; D011008:Pneumococcal Infections / Q000276:immunology; D013301:Streptolysins / Q000494:pharmacology*
D001426:Bacterial Proteins; D013301:Streptolysins; C032290:plY protein, Streptococcus pneumoniae; D007975:Leukotriene B4; D009240:N-Formylmethionine Leucyl-Phenylalanine; D015232:Dinoprostone