title: Neural activation during performance of number-letter sequencing.
abstract: Recent advances in neuroimaging have enabled researchers to establish relatively specific areas of the brain that are involved in working memory. In this positron emission tomography study we examined the pattern of neural activation associated with performance on number-letter sequencing, a purported measure of working memory included in the new Wechsler scales for memory and intelligence. After controlling for basic audition, verbalization, and attention, areas of activation were observed in the orbital frontal lobe, dorsolateral prefrontal cortex, and posterior parietal cortex. This is highly consistent with reports from the literature on activation patterns associated with working memory. More activation peaks were observed in the right hemisphere, suggesting the participants utilized visualization of the verbal information. Consistent with task conceptualization, this study provides support for number-letter sequencing as a task involving working memory.
authors: Departments of Behavioral Medicine and Psychiatry, Neurology, and Radiology, West Virginia University School of Medicine, Morgantown, West Virginia, USA. mhaut@hsc.wvu.edu
authors: M W
authors: MW
authors: Haut
authors: H
authors: H
authors: Kuwabara
authors: S
authors: S
authors: Leach
authors: R G
authors: RG
authors: Arias
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology; D001921:Brain / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008568:Memory / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology; D008606:Mental Processes / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D014055:Tomography, Emission-Computed