Likelihood-based experimental design for estimation of ED50.
In selecting the best dosage choice for the estimation of ED50, it is natural to try to minimize the length of the confidence intervals. In this presentation, the dose allocation that minimizes the length of the likelihood-based confidence intervals is presented and compared with alternative allocations that have been proposed based on the length of different types of confidence intervals, such as those based on the asymptotic variance or on Fieller's Theorem. Effective strategies to deal with the parameter dependence of these allocations are explored. A series of experiments to evaluate the effect of small doses per fraction on the radiation tolerance of the rat cervical spinal cord provide the motivation and an illustration for the proposed procedures.
Minkin
S
S
Ontario Cancer Institute and University of Toronto, Canada. minkin@oci.utoronto.ca
Kundhal
K
K
D000818:Animals; D001699:Biometry; D016001:Confidence Intervals; D004307:Dose-Response Relationship, Radiation; D007928:Lethal Dose 50; D016013:Likelihood Functions; D011836:Radiation Tolerance; D051381:Rats; D013116:Spinal Cord / Q000528:radiation effects