The TRAP/SMCC/Mediator complex and thyroid hormone receptor function.
The TRAP/SMCC/Mediator complex is a mammalian transcriptional regulatory complex that contains over 25 polypeptides and is, in part, phylogenetically conserved. It was originally isolated as a thyroid hormone receptor (TR)-associated protein (TRAP) complex that mediates TR-activated transcription from DNA templates in conjunction with the general transcription machinery, and probably acts in vivo after the action of other receptor-interacting coactivators involved in chromatin remodeling. Subsequently, the TRAP complex was identified as a more broadly used coactivator complex for a wide variety of activators. The TRAP220 subunit mediates ligand-dependent interactions of the complex with TR and other nuclear receptors; and genetic ablation of murine TRAP220 has revealed that it is essential both for optimal TR function and for a variety of early developmental and adult homeostasis events in mice, but not for cell viability per se.
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Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, 1230 York Avenue, New York, NY 10021-6399, USA.
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D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism*; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics; D004622:Embryo, Mammalian; D004625:Embryo, Nonmammalian; D005656:Fungal Proteins / Q000378:metabolism*; D007037:Hypothyroidism / Q000235:genetics; D056892:Mediator Complex; D056913:Mediator Complex Subunit 1; D051379:Mice; D009154:Mutation; D011988:Receptors, Thyroid Hormone / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D014157:Transcription Factors / Q000378:metabolism*
D002352:Carrier Proteins; D029721:Drosophila Proteins; D005656:Fungal Proteins; C538856:Med1 protein, mouse; C491486:Med6 protein, Drosophila; D056892:Mediator Complex; D056913:Mediator Complex Subunit 1; D011988:Receptors, Thyroid Hormone; C074748:SRB2 protein, S cerevisiae; D029701:Saccharomyces cerevisiae Proteins; D015534:Trans-Activators; D014157:Transcription Factors