Metastatic placental site trophoblastic tumor. Report of a case with complete response to chemotherapy.
BACKGROUND
Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia, commonly insensitive to chemotherapeutic agents.


METHODS
We report on long-term remission in a patient with metastatic PSTT after etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine combination chemotherapy. The 27-year-old patient with metastatic lung PSTT was alive, without evidence of disease, > 40 months after treatment.


CONCLUSIONS
Treatment with multiagent chemotherapy can produce long-term remission, even in patients with metastatic PSTT.
Mangili
G
G
Department of Obstetrics and Gynecology, Ospedale San Raffaele, Via Olgettina 60, 20100 Milan, Italy.
Garavaglia
E
E
De Marzi
P
P
Zanetto
F
F
Taccagni
G
G
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D012074:Remission Induction; D018245:Trophoblastic Tumor, Placental Site / Q000188:drug therapy* / Q000556:secondary*; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D014750:Vincristine / Q000627:therapeutic use
D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D008727:Methotrexate