title: Sperm characteristics and accessory sex gland functions in HIV-infected men.
abstract: A comparative study was carried out in the andrology clinic, Parirenyatwa Hospital, Harare, Zimbabwe, to investigate the sperm characteristics and accessory sex gland functions in HIV-infected individuals. Sixty-two patients with infertility problems who attended the clinic were requested to donate semen and blood after consent was obtained. HIV antibodies in paired semen and blood samples, sperm morphology, sperm count, sperm motility, seminal leucocytes, seminal fructose, seminal neutral alpha-glucosidase, and citric acid were analyzed. Nine out of 31 blood samples tested positive, while 21 out of 62 semen samples were positive for HIV. Leucocytospermia was associated with HIV-seropositive men (p < .01). The accessory sex gland function, as evaluated by biochemical markers, was not affected in HIV-seropositive men. HIV causes impairment of sperm motility by activating seminal leucocytes, which in turn induce oxidative stress on the sperm. Leucocytospermia is almost always present in HIV-seropositive men.
authors: Department of Physiology, Faculty of Health Sciences, University of Transkei, Umtata, South Africa.
authors: E
authors: E
authors: Umapathy
authors: T
authors: T
authors: Simbini
authors: T
authors: T
authors: Chipata
authors: M
authors: M
authors: Mbizvo
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005837:Genitalia, Male / Q000503:physiopathology* / Q000821:virology; D006678:HIV / Q000276:immunology / Q000302:isolation & purification; D006679:HIV Seropositivity / Q000097:blood / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007962:Leukocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012661:Semen / Q000276:immunology / Q000821:virology; D013076:Sperm Count; D013081:Sperm Motility; D013094:Spermatozoa / Q000473:pathology* / Q000502:physiology; D014759:Viral Envelope Proteins / Q000032:analysis
chemical_list: D014759:Viral Envelope Proteins