Arrangement of D-periodic collagen fibrils and association of proteoglycans with fibrils in the synovium of the mouse temporomandibular joint.
The present study was performed to examine changes in the arrangement of D-periodic collagen fibrils in the synovium of the growing temporomandibular joint in mice. At 1 week of age, the mandibular condyle was undeveloped, and only a few collagen fibrils were recognizable in the subintimal layer of the synovium. At 8 weeks, the mandibular condyle was structurally developed with an increase of collagen fibrils in the synovium; a fully mature condyle was observed at 6 months of age. The close association of proteoglycans with collagen fibrils in the synovium of the growing joint was examined by both conventional and energy-filtering transmission electron microscopy of cupromeronic blue-stained specimens. Proteoglycans were associated with D-periodic collagen fibrils in the short filamentous form in random fashion at 1 week of age, but in a regular pattern with D-periodicity at 6 months. These associations in the synovium could be correlated with the mechanical character of the temporomandibular joint.
Teramoto
T
T
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Japan.
Kobayashi
M
M
Mizutani
H
H
Sugiura
Y
Y
Ueda
M
M
D000367:Age Factors; D000818:Animals; D003094:Collagen / Q000032:analysis* / Q000648:ultrastructure; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D011509:Proteoglycans / Q000648:ultrastructure*; D013583:Synovial Membrane / Q000737:chemistry* / Q000648:ultrastructure; D013704:Temporomandibular Joint / Q000737:chemistry* / Q000254:growth & development
D011509:Proteoglycans; D003094:Collagen