[Aluminum--occurrence and toxicity for organisms].
Aluminium (Al.) is an ubiquitous element found in every food product. The sources of Al. are especially corn, yellow cheese, salt, herbs, spices, tea and tap water. In household Al.-made ware is a major source of the element. Al. may cause diseases in humans, especially hampers many metabolic processes especially turnover of calcium, phosphorus and iron. Salts of Al. may bind to DNA, RNA, inhibit such enzymes as hexokinase, acid and alkaline phosphatases, phosphodiesterase and phosphooxydase. Al. salts are especially harmful to nervous, hematopoietic systems and to skeleton. Al. gets to organism with food, water, cosmetics, from aluminium ware and containers. Toxicity comes from substitution of Mg and Fe ions effecting in disturbances in intracellular signaling, excretory functions and cellular growth. Neurotoxic action of Al. probably comes from substitution of Mg ions in ATP, what finally influences function of every ATP using-enzymes. There are observations in experimental models proving Al. salts are responsible for Alzheimer disease development. Toxicity of Al. to skeletal system results in diminished resistance thus tendencies to breaking, and comes from lower collagen synthesis and slowing down of mineralisation. Low erythropoietin production, inhibition of hem-synthesing enzymes and binding of Al. to transferrin, effects in anaemia. Carcinogenic effects of Al. were nor proved nor denied, but high concentrations of Al. were found in many neoplastic cells. In conclusion, we should introduce prophylactic measures effecting in less Al. intake esp. avoiding use of Al.-made ware nad controlling food for Al. content.
Ochmański
W
W
Katedra i Klinika Chorób Wewnetrznych, Collegium Medicum, Uniwersytetu Jagiellońskiego w Krakowie.
Barabasz
W
W
D000535:Aluminum / Q000032:analysis* / Q000506:poisoning*; D000544:Alzheimer Disease / Q000139:chemically induced / Q000517:prevention & control; D000818:Animals; D004781:Environmental Exposure / Q000032:analysis / Q000517:prevention & control*; D004784:Environmental Monitoring / Q000379:methods; D005506:Food Contamination / Q000032:analysis / Q000517:prevention & control*; D006801:Humans
D000535:Aluminum