title: On the use of historical control data for trend test in carcinogenicity studies.
abstract: Historical control data are often available in carcinogenicity studies and are included for testing dose effects in current studies. A new method is developed for incorporating the historical control information into a dose effect test. The method generalizes the test procedures proposed by Tarone (1982, Biometrics 38, 215-220) and Ibrahim and Ryan (1996, Biometrics 52, 1478-1485) by taking into account the variation resulting from parameter estimation based on historical data. Two examples are discussed for illustrating the proposed method.
authors: Department of Statistics, University of Missouri, Columbia 65211, USA. tsun@stat.missouri.edu
authors: J
authors: J
authors: Sun
mesh_terms: D000818:Animals; D001699:Biometry; D015197:Carcinogenicity Tests / Q000706:statistics & numerical data*; D002273:Carcinogens / Q000008:administration & dosage / Q000633:toxicity; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D005260:Female; D005411:Flame Retardants / Q000008:administration & dosage / Q000633:toxicity; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D008654:Mesothelioma / Q000139:chemically induced; D009571:Nitrilotriacetic Acid / Q000008:administration & dosage / Q000633:toxicity; D011409:Propylene Glycols / Q000008:administration & dosage / Q000633:toxicity; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002273:Carcinogens; D005411:Flame Retardants; D011409:Propylene Glycols; C060080:2,2-bis(bromomethyl)-1,3-propanediol; D009571:Nitrilotriacetic Acid