The interspecies sensitivity to transplacental effects of carcinogens.
Childhood cancer is a serious problem in oncology. Because the period of high sensitivity to environmental effects has been suggested to be early in life, it is thought that a variety of influences on pregnant mothers might result in the development of neoplasia in offspring. Environmental and genetic factors have been shown to play a significant role in modifying transplacental tumorigenesis. To better understand the possible mechanisms governing this phenomenon, an analysis of interspecies sensitivity to the transplacental effect of carcinogens, reviewed herein, should be of interest to many specialists in medicine and biology.
Zusman
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I
Laboratory of Experimental Oncology, Koret School of Veterinary Medicine, Faculty of Agricultural, Food and Environmental Quality Sciences, The Hebrew University of Jerusalem, Rehovot, Israel. zusmani@agri.huji.ac.il
Beniashvili
D
D
D000818:Animals; D002274:Carcinogens, Environmental / Q000494:pharmacology*; D005260:Female; D008431:Maternal-Fetal Exchange; D009369:Neoplasms / Q000139:chemically induced*; D011247:Pregnancy; D013045:Species Specificity
D002274:Carcinogens, Environmental