title: Age-related autoantibody production in a nonhuman primate model.
abstract: Autoantibody production increases with ageing. However, the pathological significance of this increase as well as the corresponding underlying mechanisms are poorly understood. To further our understanding of the role that ageing plays in the development of autoantibody responses, we used a novel nonhuman primate model consisting of healthy baboons of ages representing the entire lifespan of this animal species. Results from this study indicate that production of antinuclear antibodies, anticell extract antibodies and natural autoantibodies gradually and significantly increases from young age to old age without a corresponding increase in neither serum immunoglobulin concentration nor in levels of selected markers of immune dysregulation (sTNF-RI, sTNF-RII, IL-2 sR alpha and IFN-gamma). Therefore, in the baboon model, autoantibodies may be produced in absence of recognizable pathological conditions of the ageing immune system.
authors: Department of Biology, Georgia State University, Atlanta, 30302 USA. bioraa@panther.gsu.edu
authors: R
authors: R
authors: Attanasio
authors: K M
authors: KM
authors: Brasky
authors: S H
authors: SH
authors: Robbins
authors: L
authors: L
authors: Jayashankar
authors: R J
authors: RJ
authors: Nash
authors: T M
authors: TM
authors: Butler
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D008297:Male; D010215:Papio; D018121:Receptors, Cytokine / Q000032:analysis; D018709:Statistics, Nonparametric
chemical_list: D000974:Antibodies, Antinuclear; D018121:Receptors, Cytokine