Therapeutic implications of hypothermic and hyperthermic temperature conditions in stroke patients.
Brain temperature is an important variable in determining the outcome of cerebral ischemia; increases in core temperature escalate neural damage whereas decreases in core temperature reduce damage. Fever induction often occurs in patients prior to or as a direct or indirect result of the ischemic insult, with a worsened stroke outcome, compared with non-febrile ischemic patients. Most importantly, post-ischemic hypothermia reduces long term neural damage and associated behavioral deficits in animals studied for up to a year after the ischemic insult. This review discusses the importance of monitoring the brain temperature of stroke patients and implemention of therapeutic thermoregulatory strategies to reduce the temperature of ischemic patients.
Thornhill
J
J
Department of Physiology, University of Saskatchewan and The Saskatchewan Stroke Research Center, Saskatoon, Canada. thornhill@sask.usask.ca
Corbett
D
D
D005334:Fever / Q000503:physiopathology*; D006801:Humans; D007035:Hypothermia / Q000503:physiopathology*; D007036:Hypothermia, Induced; D020521:Stroke / Q000503:physiopathology* / Q000628:therapy*