Monomelic amyotrophy with late progression.
Monomelic amyotrophy is a sporadic juvenile-onset disease that presents with gradual onset of weakness and atrophy in the hand muscles unilaterally. Generally, this disease is considered a 'benign' and non-progressive motor neuron disease, which stabilizes within five years of onset. We discuss a case that illustrates that monomelic amyotrophy may rarely exhibit late clinical progression to the lower extremities after a prolonged period of disease stability.
Rowin
J
J
Section of Neuromuscular Disease, Department of Neurological Sciences, Rush University, Chicago, IL, USA. jrowin@rush.edu
Meriggioli
M N
MN
Cochran
E J
EJ
D017668:Age of Onset; D001706:Biopsy; D018450:Disease Progression; D006801:Humans; D007866:Leg / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology* / Q000503:physiopathology*; D009134:Muscular Atrophy, Spinal / Q000473:pathology* / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D011237:Predictive Value of Tests