title: Prolonged recording of oesophageal and lower oesophageal sphincter pressure using a portable water-perfused manometric system.
abstract: The aim of our study was to investigate the recording fidelity of a water-perfused micromanometric catheter with incorporated sleeve combined with a newly developed portable water-perfused manometric system for pharyngeal, oesophageal and lower oesophageal sphincter (LOS) pressure recording. The system's performance was assessed in prolonged recordings in ambulant gastro-oesophageal reflux disease (GORD) patients. Eighty 24-h studies in GORD patients, carried out with the perfused portable manometric system, were evaluated. Twelve of these recordings were analysed in detail in order to compare oesophageal and LOS motor patterns with those described previously. Paired 2-h manometric recordings of the pharynx, oesophagus, LOS and stomach, using the new system and a conventional perfused stationary manometric system, were performed in eight healthy subjects. With the portable manometric system oesophageal contractions, transient LOS relaxations, swallow-associated prolonged LOS relaxations and LOS pressures were recorded with equal fidelity to the conventional manometric system. Recordings obtained with the portable system showed meal-related and diurnal variations in oesophageal and LOS variables that were similar to these found in studies using conventional equipment. The new manometric system, consisting of a perfused micromanometric catheter with incorporated sleeve and a portable perfusion system, enables prolonged studies on oesophageal and LOS motor patterns in ambulant subjects.
authors: Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Center Utrecht, The Netherlands.
authors: M A
authors: MA
authors: Van Herwaarden
authors: M
authors: M
authors: Samsom
authors: L M
authors: LM
authors: Akkermans
authors: A J
authors: AJ
authors: Smout
mesh_terms: D000328:Adult; D004943:Esophagogastric Junction / Q000502:physiology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology; D006801:Humans; D008124:Locomotion; D008297:Male; D008365:Manometry / Q000295:instrumentation* / Q000379:methods* / Q000592:standards; D008875:Middle Aged; D015203:Reproducibility of Results; D014867:Water
chemical_list: D014867:Water