Antifungal mechanism of polygodial.
The primary antifungal action of polygodial comes in part from its ability to function as a nonionic surfactant, disrupting the lipid-protein interface of integral proteins and denaturing their conformation. As a result, the antifungal mechanism of this sesquiterpene dialdehyde is associated with the membrane functions or derangement of the membrane. For example, the glucose-induced medium acidification process of Saccharomyces cerevisiae was inhibited by polygodial, presumably caused by inhibition of the plasma membrane H(+)-ATPase. However, the potent antifungal activity of polygodial results from its multiple functions.
Kubo
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Department of Environmental Science, Policy and Management, University of California, Berkeley, CA 94720-3112, USA. ikubo@uclink4.berkeley.edu
Fujita
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Lee
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D000081248:Allylbenzene Derivatives; D000840:Anisoles / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002462:Cell Membrane / Q000201:enzymology; D003470:Culture Media; D005947:Glucose / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D006180:Proton-Translocating ATPases / Q000037:antagonists & inhibitors; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism; D012717:Sesquiterpenes / Q000494:pharmacology*
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D000935:Antifungal Agents; D003470:Culture Media; D012717:Sesquiterpenes; C034380:polygodial; D006180:Proton-Translocating ATPases; D005947:Glucose; C006578:anethole