Molecular basis of partial lipodystrophy and prospects for therapy.
Lipodystrophy is characterized by altered partition of adipose tissue. Despite heterogeneous causes, which include genetic, autoimmune and drug-induced forms, lipodystrophy syndromes have similar metabolic attributes, including insulin resistance, hyperlipidemia and diabetes. The mechanisms underlying the insulin resistance are unknown. One form of lipodystrophy, namely Dunnigan-type familial partial lipodystrophy (FPLD) was shown to result from mutations in the LMNA gene, which encodes nuclear lamins A and C. Although the relationship between the mutations in the nuclear envelope and insulin resistance is unclear at present, these findings might eventually be shown to have relevance for the common insulin resistance syndrome and for drug-associated lipodystrophies.
Hegele
R A
RA
Blackburn Cardiovascular Genetics Laboratory, Robarts Research Institute, 406-100 Perth Drive, London, Ontario, Canada N6A 5K8. robert.hegele@rri.on.ca
D010450:Endopeptidases / Q000378:metabolism; D006801:Humans; D034882:Lamins; D008060:Lipodystrophy / Q000188:drug therapy* / Q000235:genetics*; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D013577:Syndrome; D013844:Thiazoles / Q000494:pharmacology
D034882:Lamins; D009687:Nuclear Proteins; D013844:Thiazoles; D010450:Endopeptidases