Bioactive constituents from gum guggul (Commiphora wightii).
Bioactivity-directed fractionation and purification afforded cytotoxic components of Commiphora wightii. The exudates of C. wightii were extracted with EtOAc and the extract was subjected to repeated column chromatography. A fraction showing cytotoxic activity was characterized as a mixture of two ferulates with an unusual skeleton by spectral and chemical methods, including by NMR, GC-MS and chemical derivatization. This fraction also showed moderate scavenging effect against 2,2-diphenyl-1-picrylhydrazyl (DPPH) radicals.
Zhu
N
N
Department of Food Science and Center for Advanced Food Technology, Rutgers University, New Brunswick, NJ 08901, USA.
Rafi
M M
MM
DiPaola
R S
RS
Xin
J
J
Chin
C K
CK
Badmaev
V
V
Ghai
G
G
Rosen
R T
RT
Ho
C T
CT
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D001943:Breast Neoplasms; D002470:Cell Survival / Q000187:drug effects*; D029744:Commiphora; D005260:Female; D016166:Free Radical Scavengers / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010936:Plant Extracts / Q000737:chemistry*; D053149:Plant Gums; D011471:Prostatic Neoplasms; D019685:Rosales / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D016166:Free Radical Scavengers; D007202:Indicators and Reagents; D010936:Plant Extracts; D053149:Plant Gums; C018562:guggulu extract