Changes in monoaminergic activity in the anterior, medium and posterior hypothalamus, gonadotropins levels and ovarian hormones during puberty of the female rat.
The aim of present study is the analysis of monoamines concentrations changes in the anterior, medium and posterior hypothalamus, as well as changes in serum gonadotropins levels, ovarian steroids and follicular growth during the prepubertal development of the female rat. Noradrenergic activity in the anterior, medium and posterior hypothalamus reached highest level at day 13 after birth, followed by a subsequent decrease from day 15 to 19 and an increase on days 22 and 27 postnatal. At day 1, neural activity in the medium hypothalamus was higher than the activity in the anterior and posterior hypothalamus. Serotoninergic activity in three portions of the hypothalamus was higher throughout the prepubertal development. Follicle-stimulating hormone and luteinizing hormone serum levels increased between days 11 and 17 and decreased from day 19 to 36. The concentration of 17beta-estradiol was consistently low throughout the prepubertal development and increased at day 39 after birth. These results indicate that during the prepubertal development of the rat, the three regions of the hypothalamus show significant changes in the monoaminergic neural activity. There is an inverse relationship between the noradrenergic activity on the anterior and medium hypothalamus and serotoninergic activity in the posterior hypothalamus with ovarian steroids during sexual maturation. These changes may be linked to the development of the neuroendocrine processes that modulate gonadotropin secretion and ovarian function.
Castro
M E
ME
Biology of Reproduction Research Unit, Laboratory of Puberty; Facultad de Estudios Superiores Zaragoza, Universidad Nacional Autónoma de México, México City, Mexico.
Ayala
M E
ME
Monroy
J
J
Chavira
R
R
Damian-Matsumura
P
P
Domínguez
R
R
D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000378:metabolism; D007032:Hypothalamus, Anterior / Q000378:metabolism*; D007033:Hypothalamus, Middle / Q000378:metabolism*; D007034:Hypothalamus, Posterior / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood; D009929:Organ Size / Q000502:physiology; D006080:Ovarian Follicle / Q000378:metabolism; D010053:Ovary / Q000378:metabolism; D051381:Rats; D012741:Sexual Maturation / Q000502:physiology*; D014599:Uterus / Q000378:metabolism
D015306:Biogenic Monoamines; D006062:Gonadotropins; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone