title: Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney.
abstract: We report the cloning, characterization, and chromosomal localization of two novel human members of the bicarbonate transporter superfamily, BTR1 (Bicarbonate Transporter Related protein-1) and AE4 (Anion Exchange protein 4). BTR1 is a novel mammalian protein. The BTR1 gene maps to chromosome 20p12 and encodes a 100 kDa protein predominantly expressed in the kidney, salivary glands, testis, thyroid glands, and trachea. The AE4 gene maps to chromosome 5q23-31 and encodes a 104 kDa protein expressed mainly in the kidney. Human AE4 shares 84% identity with the recently reported rabbit AE4, a sodium independent, Cl(-)/HCO(-)(3) exchanger located on the apical membrane of beta-intercalated kidney cells.
authors: Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom.
authors: M D
authors: MD
authors: Parker
authors: E P
authors: EP
authors: Ourmozdi
authors: M J
authors: MJ
authors: Tanner
mesh_terms: D020816:Amino Acid Motifs / Q000235:genetics; D027321:Anion Transport Proteins; D017920:Antiporters / Q000235:genetics* / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D002474:Cell-Free System; D027963:Chloride-Bicarbonate Antiporters; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D003001:Cloning, Molecular; D006031:Glycosylation; D006801:Humans; D016623:Ion Pumps / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D009928:Organ Specificity; D020161:Physical Chromosome Mapping; D014176:Protein Biosynthesis; D017386:Sequence Homology, Amino Acid; D027982:Sodium-Bicarbonate Symporters
chemical_list: D027321:Anion Transport Proteins; D017920:Antiporters; D001639:Bicarbonates; D027963:Chloride-Bicarbonate Antiporters; D016623:Ion Pumps; C425809:SLC4A11 protein, human; C440068:SLC4A9 protein, human; D027982:Sodium-Bicarbonate Symporters