title: Fibrosarcoma mimicking plasmacytoma or carcinoma: an ultrastructural study of 4 cases.
abstract: Because the fibroblast has a remarkable capability of phenotypic modulations, reflected in both morphologic and immunohistochemical (IHC) changes, ultrastructural studies are mandatory to identify the variants of fibroblasts. Myofibroblasts or histiofibroblasts are such examples, demonstrating chimeric ultrastructural features of fibroblastic cells in common with smooth muscle cells or with histiocytes, respectively. The presence of epithelioid fibroblastic cells sharing morphologic features with epithelial or plasma cells has not been yet characterized. The authors identified 4 cases of fibrosarcomas (FS) characterized by an unusual phenotype and associated with peculiar ultrastructural findings. The electron microscopic (EM) findings were correlated with the histologic appearance and immunoprofile. All tumors were located in the extremities, 3 in soft tissues and 1 in the bone. By light microscopy 2 cases were composed predominantly by round uniform cells with a striking plasmacytoid appearance. One case mimicked carcinoma, composed predominantly by epithelioid cells and scattered giant tumor cells. The fourth case showed a mixture of plasmacytoid-like and epithelioid cells. By IHC, tumor cells were positive for vimentin and in 2 cases also for epithelial membrane antigen. Kappa/lambda light chain and cytokeratins markers were negative. By EM all 4 tumors showed in addition to classic features of fibroblasts, unusual epithelial-type features, such as secretory granules of "neurosecretory-type" (3 cases), rudimentary cell junctions (3 cases), microvilli (2 cases), and lumen-like structures (1 case). One plasmacytoid-type tumor showed finely granular extracellular deposits. The study describe 4 examples of fibrosarcomas with unusual features at the ultrastructural level, which are associated microscopically with a peculiar phenotype, mimicking plasmacytoma or carcinoma. These findings broaden the spectrum of fibroblastic cell variants in neoplasia.
authors: Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. antonesc@mskcc.org
authors: C R
authors: CR
authors: Antonescu
authors: R A
authors: RA
authors: Erlandson
mesh_terms: D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000648:ultrastructure; D022083:Cytoplasmic Structures / Q000648:ultrastructure; D003937:Diagnosis, Differential; D015622:Epithelioid Cells / Q000648:ultrastructure; D005260:Female; D005347:Fibroblasts / Q000648:ultrastructure; D005354:Fibrosarcoma / Q000737:chemistry / Q000175:diagnosis / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D010954:Plasmacytoma / Q000175:diagnosis / Q000648:ultrastructure*; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000648:ultrastructure*
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins