Frequency of protein Z deficiency in patients with ischaemic stroke.
Prothrombotic phenotype has been described in protein-Z deficient mice, but the thrombotic risk associated with protein Z deficiency in human beings is unknown. We saw a protein Z plasma concentration deficiency of about 20% in 169 patients, from two hospitals, who had ischaemic stroke, whereas the frequency in 88 controls was about 5%. We saw no increase in the frequency of protein Z deficiency in 56 patients with venous thrombophilia. However, why protein Z deficiency was only observed in arterial thrombosis remains unknown.
Vasse
M
M
Guegan-Massardier
E
E
Borg
J Y
JY
Woimant
F
F
Soria
C
C
D000328:Adult; D001798:Blood Proteins / Q000172:deficiency*; D020520:Brain Infarction / Q000097:blood*; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D008297:Male; D020246:Venous Thrombosis / Q000097:blood
D001798:Blood Proteins; C026080:plasma protein Z