title: Ring-deactivated hydroxymethylpyrroles as inhibitors of alpha-chymotrypsin.
abstract: N-Acyl and N-sulfonylhydroxymetyhylpyrroles have been synthesised and shown to inhibit alpha-chymotrypsin. A hydrophobic group in the N-substituent has been shown to be required for activity.
authors: Department of Chemistry, University of Canterbury, Christchurch, New Zealand. a.abell@chem.canterbury.ac.nz
authors: A D
authors: AD
authors: Abell
authors: B K
authors: BK
authors: Nabbs
mesh_terms: D000818:Animals; D002417:Cattle; D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D007700:Kinetics; D011758:Pyrroles / Q000138:chemical synthesis / Q000494:pharmacology*; D015842:Serine Proteinase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D011758:Pyrroles; D015842:Serine Proteinase Inhibitors; D002918:Chymotrypsin; C117608:alpha-chymotrypsin