A fatal case of serotonin syndrome after combined moclobemide-citalopram intoxication.
We present a case involving a fatality due to the combined ingestion of two different types of antidepressants. A 41-year-old Caucasian male, with a history of depression and suicide attempts, was found deceased at home. Multiple containers of medication, the MAO-inhibitor moclobemide (Aurorix), the SSRI citalopram (Cipramil), and the benzodiazepine lormetazepam (Noctamid) as active substance, as well as a bottle of whiskey were present at the scene. The autopsy findings were unremarkable, but systematic toxicological analysis (EMIT, radioimmunoassay, high-performance liquid chromatography-diode-array detection [HPLC-DAD], gas chromatography-nitrogen-phosphorus detection, and gas chromatography-mass spectrometry) revealed the following: ethanol (0.23 g/L blood, 0.67 g/L urine), lormetazepam (1.65 microg/mL urine), cotinine (0.63 microg/mL blood, 5.08 microg/mL urine), caffeine (1.20 microg/mL urine), moclobemide (and metabolites), and citalopram (and metabolite). There upon, we developed a new liquid chromatographic separation with optimized DAD, preceded by an automated solid-phase extraction, for the quantitation of the previously mentioned antidepressive drugs. The results obtained for blood and urine, respectively, were as follows: Ro 12-5637 (moclobemide N'-oxide) not detected and 424 microg/mL; Ro 12-8095 (3-keto-moclobemide) 2.26 microg/mL and 49.7 microg/mL; moclobemide 5.62 microg/mL and 204 microg/mL; desmethylcitalopram 0.42 microg/mL and 1.22 microg/mL; and citalopram 4.47 microg/mL and 19.7 microg/mL. The cause of death was attributed to the synergistic toxicity of moclobemide and citalopram, both antidepressants, which, by intentional or accidental combined ingestion, can produce a potentially lethal hyperserotoninergic state. Based on the history of the case and pharmacology of the drugs involved, the forensic pathologists ruled that the cause of death was multiple drug intoxication, resulting in a fatal "serotonin syndrome," and that the manner of death was suicide.
Dams
R
R
Laboratorium voor Toxicologie, Universiteit Gent, Belgium.
Benijts
T H
TH
Lambert
W E
WE
Van Bocxlaer
J F
JF
Van Varenbergh
D
D
Van Peteghem
C
C
De Leenheer
A P
AP
D000328:Adult; D000928:Antidepressive Agents / Q000378:metabolism / Q000506:poisoning*; D002851:Chromatography, High Pressure Liquid; D015283:Citalopram / Q000378:metabolism / Q000506:poisoning*; D004338:Drug Combinations; D017248:Enzyme Multiplied Immunoassay Technique; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D020912:Moclobemide / Q000378:metabolism / Q000506:poisoning*; D011863:Radioimmunoassay; D020230:Serotonin Syndrome / Q000139:chemically induced* / Q000473:pathology; D013405:Suicide
D000928:Antidepressive Agents; D004338:Drug Combinations; D015283:Citalopram; D020912:Moclobemide