title: Serum homocysteine and lipoprotein (a) concentrations in hypercholesterolemic and normocholesterolemic children.
abstract: The relationship between lipids, lipoproteins, total homocysteine, and lipoprotein (a) was studied in hypercholesterolemic and normocholesterolemic children. In hypercholesterolemic children, concentrations of total cholesterol, low-density lipoprotein (LDL) cholesterol, apolipoprotein B, and triglycerides were significantly higher compared to levels in controls, whereas concentrations of high-density lipoprotein (HDL) cholesterol and apolipoprotein A-I were lower compared to those in the control group. Total serum homocysteine concentrations in children with a positive family history for cardiovascular disease CHD(+) (7.28 micromol/L) were significantly higher than those in the control group (5.45 micromol/L), and in the group of CHD(-) children (5.25 micromol/L). The median value of lipoprotein (a) in patients was 31.5 mg/dL (range, 11-209 mg/dL) and in the control group, 19 mg/dL (range, 11-95 mg/dL). Concentrations of Lp (a), exceeding 30 mg/dL, were present in 45% of CHD(+) children, in 29% of CHD(-) children, and in only 11% of the control group.
authors: Department of Biochemistry, Research National Institute of Mother and Child, Warsaw, Poland.
authors: T
authors: T
authors: Laskowska-Klita
authors: E
authors: E
authors: Szymczak
authors: B
authors: B
authors: Radomyska
mesh_terms: D000293:Adolescent; D002318:Cardiovascular Diseases / Q000235:genetics; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism*; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D012307:Risk Factors
chemical_list: D017270:Lipoprotein(a); D006710:Homocysteine