Analgesic and antipyretic effects of Dodonaea angustifolia and Salvia africana-lutea.
Water extracts of Dodonaea angustifolia L. and Salvia africana-lutea L., were investigated for analgesic and antipyretic activities using acetic acid writhing and hot plate tests, and lipopolysaccharide (LP)-induced pyrexia test in mice and rats, respectively. D. angustifolia and S. africana-lutea significantly inhibited acetic acid-induced writhing and also significantly delayed the time of reaction of mice to thermal stimulation produced by the hot plate. D. angustifolia and S. africana-lutea significantly reduced fever induced by LP. Paracetamol produced similar effects to D. angustifolia and S. africana-lutea on the acetic acid-induced writhing but has no effect on hot plate-induced nociception and on pyrexia produced by LP. These data indicate the analgesic and antipyretic potential of D. angustifolia and S. africana-lutea.
Amabeoku
G J
GJ
Department of Pharmacology, School of Pharmacy, University of the Western Cape, Private Bag X17, 7535, Bellville, South Africa. gamabeoku@uwc.ac.za
Eagles
P
P
Scott
G
G
Mayeng
I
I
Springfield
E
E
D000700:Analgesics / Q000494:pharmacology*; D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D019686:Lamiaceae / Q000737:chemistry*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
D000700:Analgesics; D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts