Management of oral anticoagulants in the treatment of venous thromboembolism.
Venous thromboembolism still represents a major public health problem. After initial heparin therapy, oral anticoagulants are the treatment most often used. Bleeding is the major risk of such a therapy. This review of the literature emphasises the practical aspects of the clinical management of oral anticoagulant therapy, such as initiation, monitoring, interaction, withdrawal, optimal duration, bleeding complications and non-haemorrhagic adverse reactions.
Pinede
L
L
Department of Internal Medicine, Edouard Herriot Hospital, 69437 Cedex 03, Lyons, France
Duhaut
P
P
Ninet
J
J