Apolipoprotein H is increased in type 2 diabetic patients with microalbuminuria.
OBJECTIVE
Serum apolipoprotein H (Apo H) levels are increased in hyperlipidemic subjects and type 2 diabetics, but unknown in microalbuminuria, another disorder with an increased cardiovascular risk. We looked to see whether increased Apo H levels are associated with microalbuminuria in type 2 diabetes.


RESULTS
Serum Apo H was calculated in 20 normoalbuminuric and 17 microalbuminuric type 2 diabetics matched for age, sex, body mass index (BMI), glycosylated haemoglobin, plasma lipids and duration of diabetes, and also compared with 20 non-diabetic controls matched for age, sex, BMI and plasma lipids. Mean serum Apo H was significantly higher in the microalbuminuric patients (31.12 +/- 1.58 SEM vs 25.25 +/- 1.52 and 24.72 +/- 0.99 mg/dL, p = 0.003).


CONCLUSIONS
Serum apo H levels are increased in type 2 diabetics with microalbuminuria.
Cavallo Perin
P
P
Department of Internal Medicine, University of Turin, Turin, Italy.
Gruden
G
G
Giunti
S
S
Arnaldi
L
L
Cassader
M
M
Gambino
R
R
Pagano
G
G
D000419:Albuminuria / Q000097:blood*; D000925:Anticoagulants / Q000097:blood; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D053482:beta 2-Glycoprotein I
D000925:Anticoagulants; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I