Homing receptor expression on cord blood T lymphocytes and the development of atopic eczema in infants.
Expression of the gut-homing receptor integrin alphaEbeta7, but not cutaneous lymphocyte-associated antigen (CLA), on milk allergen-stimulated cord blood T lymphocytes precedes the development of milk-induced eczema in early infancy. The data indicate the involvement of integrin alphaEbeta7 in the development of infantile allergic eczema and provide a clue to the avoidance of specific allergens and novel therapy targeting homing receptors in food allergy.
Kohno
Y
Y
Department of Pediatrics, School of Medicine, Chiba University, Japan. kohnoy@med.m.chiba-u.ac.jp
Shimojo
N
N
Kojima
H
H
Katsuki
T
T
D000485:Allergens / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D002364:Caseins / Q000276:immunology; D002478:Cells, Cultured; D003876:Dermatitis, Atopic / Q000276:immunology*; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D007223:Infant; D016023:Integrins / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D016269:Milk Hypersensitivity / Q000276:immunology*; D016201:Receptors, Lymphocyte Homing / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000276:immunology*
D000485:Allergens; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; C063419:CTAGE1 protein, human; D002364:Caseins; D016023:Integrins; D008562:Membrane Glycoproteins; D016201:Receptors, Lymphocyte Homing; C070709:integrin alphaEbeta7