[Comparison of 2 therapeutic strategies in severe endometriosis, in young women consulting for sterility or pain. II. In the case of infertility, value of ovarian stimulation with intrauterine insemination after surgery].
OBJECTIVE
Define the best medico surgical strategy in infertile women with stage III-IV endometriosis.


METHODS
Two groups, A (N26) and B (N 37), treated for infertility associated or not with pelvic pain, due to stage AFS III or IV endometriosis, were compared. They had similar surgical procedure: operative laparoscopy including resection of endometriotic lesions, more particularly endometriomas and rectovaginal septum nodules. Associated medical strategy was different: group A, operative laparoscopy without preoperative treatment and in 40% a second laparoscopy taking place after 2-3 months of LHRH analogues; no post operative treatment; group B, operative laparoscopy taking place after ovarian blockage with 3-6 weeks of Diane (Androcur + ethinyl estradiol), then 2-3 months of analogue postoperative treatment immediately followed by ovarian stimulation (OS) + intrauterine insemination (IUI) in women more than 30 years old with operative tubes (N 22), no treatment for six months in similar cases less than 30 (N 5), and IVF in women with damaged tubes (N 5) or after OS + IUI failure (N 4). One patient refused two patients with high FSH level had oocyte donation.


RESULTS
Two years evolutive pregnancy rate was significantly higher (p < 0.01) in group B (59%) versus group A (23%) and was higher after OS + IUI (68%) than after IVF (55%) or without any treatment in women < 30 (43%). The difference is equally significant by age (p < 0.05), for endometriomas (p < 0.01) and for recurrences (p < 0.01).


CONCLUSIONS
Similar results obtained for pelvic pain (see chapter I) suggest that both strategies are similarly successful in treating endometriosis. These results confirm the interest of an ART after surgery for stage III-IV endometriosis and show that OS + IUI, a less costly than IVF technique, can be used successfully in selected cases with operative tubes.
el Amrani
R
R
Service de gynécologie-obstétrique et reproduction humaine, hôpital Jean-Rostand, 141, Grande Rue, 92311, Sèvres, France.
Henry-Suchet
J
J
Cornier
E
E
Sarjdine
K
K
Mayenga
J M
JM
Loysel
T
T
Belaisch-Allart
J
J
D000328:Adult; D000726:Androgen Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D017373:Cyproterone Acetate / Q000008:administration & dosage / Q000627:therapeutic use; D004338:Drug Combinations; D004715:Endometriosis / Q000150:complications*; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives; D006801:Humans; D007247:Infertility, Female / Q000209:etiology* / Q000601:surgery / Q000628:therapy*; D007315:Insemination, Artificial; D010535:Laparoscopy; D010062:Ovulation Induction; D011247:Pregnancy; D012008:Recurrence; D012189:Retrospective Studies
D000726:Androgen Antagonists; D004338:Drug Combinations; D007987:Gonadotropin-Releasing Hormone; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; C032640:Cyproterone acetate, ethinyl estradiol drug combination