Glycodelins.
Glycodelin is a major glycoprotein that is synthesized in the endometrium in response to progesterone and relaxin exposure. Endometrium-derived glycodelin-A has contraceptive and immunosuppressive properties. Glycodelin is absent from the endometrium during the fertile periovulatory phase, but is synthesized in this tissue during the peri-implantation phase and is abundant during the last week of the luteal phase. Changes in local and/or circulating glycodelin concentrations have been observed in women with reproductive disorders. The chemical modification of glycodelins has resulted in compounds with antiviral activity.
Seppälä
M
M
Dept of Obstetrics and Gynecology, Helsinki University Central Hospital, Haartmaninkatu 2, FIN-00290 Helsinki, Finland. markku.seppala@hus.fi
Koistinen
H
H
Koistinen
R
R
D000595:Amino Acid Sequence; D000818:Animals; D002240:Carbohydrate Sequence; D005187:Fallopian Tubes / Q000502:physiology; D005260:Female; D000071816:Glycodelin; D006023:Glycoproteins / Q000502:physiology*; D006031:Glycosylation; D006801:Humans; D007108:Immune Tolerance; D008969:Molecular Sequence Data; D010053:Ovary / Q000502:physiology*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000502:physiology*; D011374:Progesterone / Q000378:metabolism; D012065:Relaxin / Q000378:metabolism; D012661:Semen / Q000378:metabolism*; D014599:Uterus / Q000502:physiology*
D000071816:Glycodelin; D006023:Glycoproteins; C045246:PAEP protein, human; D011257:Pregnancy Proteins; D011374:Progesterone; D012065:Relaxin