title: A new bisphosphonate treatment option for giant cell tumors.
abstract: Treatment of giant cell tumors (GCT) especially in the vertebrae remains controversial. With multidisciplinary treatments, their results are still insufficient. Moreover, GCT shows the potential for malignant transformation and metastasis, additional options such as adjuvant medication must be considered. We report favorable results in three consecutive cases diagnosed with GCT of the spine which were treated with radiotherapy and bisphosphonate (BP) as a new treatment option, and present a review of the literature and a comparison with these case reports.
authors: Department of Radiation Oncology, University of Tokyo, Tokyo, Japan.
authors: N
authors: N
authors: Fujimoto
authors: K
authors: K
authors: Nakagawa
authors: A
authors: A
authors: Seichi
authors: A
authors: A
authors: Terahara
authors: M
authors: M
authors: Tago
authors: Y
authors: Y
authors: Aoki
authors: Y
authors: Y
authors: Hosoi
authors: K
authors: K
authors: Ohtomo
mesh_terms: D000328:Adult; D000368:Aged; D004164:Diphosphonates / Q000627:therapeutic use*; D005870:Giant Cell Tumors / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D006801:Humans; D008297:Male; D018714:Radiotherapy, Adjuvant; D013125:Spinal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D014057:Tomography, X-Ray Computed
chemical_list: D004164:Diphosphonates