Tissue engineering research in oral implant surgery.
In this article, we introduce some of the more extensively evaluated technologies using concepts of tissue engineering. We report on hard tissue engineering and soft tissue engineering and their utility for dental implant therapy. For hard tissue engineering, we evaluated human recombinant bone morphogenetic protein-2 and marrow mesenchymal stem cells using a model of sinus augmentation procedure in rabbit. We also describe distraction osteogenesis as another category for hard tissue engineering. In addition, we evaluate soft tissue management using cultured epithelial grafting for soft tissue engineering. The results of our tissue regeneration materials and methods in this study are positive. When the tissue engineering materials are used in clinics in the future, implant surgery could be the leading field.
Ueda
M
M
Department of Oral and Maxillofacial Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Tohnai
I
I
Nakai
H
H
D020341:Absorbable Implants; D000818:Animals; D001698:Biomedical Engineering; D019485:Bone Morphogenetic Proteins / Q000008:administration & dosage*; D016025:Bone Transplantation; D002130:Calcium Phosphates / Q000008:administration & dosage; D002478:Cells, Cultured; D003094:Collagen; D003757:Dental Implantation; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007085:Ilium; D020007:Implants, Experimental; D008297:Male; D008334:Mandible / Q000601:surgery; D008443:Maxillary Sinus / Q000601:surgery; D008875:Middle Aged; D009061:Mouth Mucosa / Q000637:transplantation*; D016348:Osseointegration; D010012:Osteogenesis; D019857:Osteogenesis, Distraction; D011817:Rabbits; D011994:Recombinant Proteins / Q000008:administration & dosage*; D013524:Surgical Flaps
D019485:Bone Morphogenetic Proteins; D002130:Calcium Phosphates; D011994:Recombinant Proteins; C485817:beta-tricalcium phosphate; D003094:Collagen; C018392:tricalcium phosphate