Immunohistochemical detection of ERbeta in breast cancer: towards more detailed receptor profiling?
Oestrogen receptor (ER) is used routinely to predict endocrine responsiveness in patients with breast cancer. A second ER, ERbeta has been described but its significance remains undefined; most studies have described mRNA levels rather than protein expression. Here, we demonstrate for the first time, immunohistochemical detection of ERbeta in archival breast tumours.
Skliris
G P
GP
Molecular Medicine Unit, University of Leeds, St James's University Hospital, Clinical Sciences Building, Leeds, LS9 7TF.
Carder
P J
PJ
Lansdown
M R
MR
Speirs
V
V
D001940:Breast / Q000737:chemistry / Q000473:pathology; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D011960:Receptors, Estrogen / Q000032:analysis*
D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen