Integrin-associated protein (CD47) and its ligands.
Integrin-associated protein (IAP or CD47) is a receptor for thrombospondin family members, a ligand for the transmembrane signaling protein SIRP alpha and a component of a supramolecular complex containing specific integrins, heterotrimeric G proteins and cholesterol. Peptides containing a VVM motif in the C-terminal domain of thrombospondins are agonists for CD47, initiating heterotrimeric Gi protein signaling that augments the functions of integrins of the beta 1, beta 2 and beta 3 families, thus modulating a range of cell activities including platelet activation, cell motility and adhesion, and leukocyte adhesion, migration and phagocytosis.
Brown
E J
EJ
Program in Host-Pathogen Interactions, University of California San Francisco, San Francisco, CA 94143, USA.
Frazier
W A
WA
D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000378:metabolism*; D000943:Antigens, Differentiation; D051928:CD47 Antigen; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism*; D002465:Cell Movement / Q000502:physiology; D002633:Chemotaxis / Q000502:physiology; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D016023:Integrins / Q000737:chemistry / Q000378:metabolism*; D007962:Leukocytes / Q000737:chemistry; D008024:Ligands; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000378:metabolism; D009130:Muscle, Smooth / Q000166:cytology / Q000502:physiology; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules / Q000737:chemistry* / Q000378:metabolism; D010587:Phagocytosis / Q000502:physiology; D011485:Protein Binding / Q000502:physiology; D011971:Receptors, Immunologic; D015398:Signal Transduction; D019699:Thrombospondins / Q000737:chemistry* / Q000378:metabolism
D015703:Antigens, CD; D000943:Antigens, Differentiation; D051928:CD47 Antigen; C497894:CD47 protein, human; D002352:Carrier Proteins; D016023:Integrins; D008024:Ligands; D008562:Membrane Glycoproteins; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules; D011971:Receptors, Immunologic; D019699:Thrombospondins; D020962:Heterotrimeric GTP-Binding Proteins