title: Mosquitocidal, nematicidal, and antifungal compounds from Apium graveolens L. seeds.
abstract: The methanolic extract of Apium graveolens seeds was investigated for bioactive compounds and resulted in the isolation and characterization of mosquitocidal, nematicidal, and antifungal compounds sedanolide (1), senkyunolide-N (2), and senkyunolide-J (3). Their structures were determined by 1H and 13C NMR spectral methods. Compounds 1-3 gave 100% mortality at 25, 100, and 100 microg mL(-1), respectively, on the nematode, Panagrellus redivivus. Compound 1 showed 100% mortality at 50 microg mL(-1) on nematode, Caenorhabditis elegans, and fourth-instar mosquito larvae, Aedes aegyptii. Also, it inhibited the growth of Candida albicans and Candida parapsilasis at 100 microg mL(-1). Compounds 2 and 3 were isolated for the first time from A. graveolens. This is the first report of the mosquitocidal, nematicidal, and antifungal activities of compounds 1-3.
authors: Bioactive Natural Products and Phytoceuticals, Department of Horticulture and National Food Safety and Toxicology Center, Michigan State University, East Lansing 48824, USA.
authors: R A
authors: RA
authors: Momin
authors: M G
authors: MG
authors: Nair
mesh_terms: D000330:Aedes / Q000187:drug effects; D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000969:Antinematodal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019661:Apiaceae; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects; D002175:Candida / Q000187:drug effects / Q000254:growth & development; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000432:Methanol; D009348:Nematoda / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry; D012639:Seeds / Q000737:chemistry*
chemical_list: D000935:Antifungal Agents; D000969:Antinematodal Agents; D001572:Benzofurans; D007306:Insecticides; D010936:Plant Extracts; C045855:3-N-butyl-4,5-dihydrophthalide; D000432:Methanol