Statistical parameters in behavioral tasks and implications for sample size of C57BL/6J:129S6/SvEvTac mixed strain mice.
Most mixed strain progeny from gene-knockout experiments typically originate from C57BL/6J and one of the 129 substrains, frequently 129S6/SvEvTac. The results of this behavioral survey suggest that C57BL/6J:129S6/SvEvTac mixed strain mice are amenable to behavioral testing. The variability in behavioral tasks for subjects arising from this mixed strain genetic background does not preclude screening with a battery of behavioral tests. With clues provided by a screen of mixed strain subjects, follow-up analyses with isogenic, congenic, or F1 hybrid animals may be targeted to specific behavioral themes.
Estill
S J
SJ
Department of Biochemistry, UT Southwestern Medical Center at Dallas, TX 75390-8573, USA.
Fay
K
K
Garcia
J A
JA
D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal; D003216:Conditioning, Operant; D005239:Fear; D008297:Male; D018782:Maze Learning; D051379:Mice; D008810:Mice, Inbred C57BL; D013045:Species Specificity