title: Effects of strain level and proteoglycan depletion on preconditioning and viscoelastic responses of rat dorsal skin.
abstract: The mechanical response of rat dorsal skin was experimentally studied under cyclic uniaxial ramp stretches to various strain levels. Special emphasis was paid to the effects of the preconditioning protocol on the stress-strain relationship, and to the effects of ramp strain level and proteoglycan (PG) depletion, on viscoelasticity and preconditioning responses. The results show that preconditioning significantly reduced both the slope of the low strain stress-strain relationship, and the stress levels at consecutive stretch cycles. Following a short rest there was a significant partial recovery. Stress decay due to preconditioning was significant at all strain levels, and increased with strain. Stress relaxation was significant at all strain levels, but varied little with strain. Recovery following a 10 min rest was minor at all strain levels and varied little with strain. PG-depleted samples manifested similar response patterns. These results are consistent with the following notion: (1) skin consists of three mechanical components: elastin and proteoglycan which dominate the low strain response and are effected by preconditioning and (PG) depletion, and collagen which dominates the high strain response and is unaffected by preconditioning and PG depletion; (2) that the viscoelasticity of elastin and PG vs that of collagen are similar, so that rat dorsal skin can be regarded quasilinear viscoelastic.
authors: Department of Biomedical Engineering, Technion-Israel Institute of Technology, Haifa.
authors: H
authors: H
authors: Eshel
authors: Y
authors: Y
authors: Lanir
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001698:Biomedical Engineering; D004548:Elasticity; D005260:Female; D066298:In Vitro Techniques; D011509:Proteoglycans / Q000302:isolation & purification / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012879:Skin Physiological Phenomena; D013314:Stress, Mechanical; D014783:Viscosity
chemical_list: D011509:Proteoglycans