title: [Laser-induced thermotherapy (LITT). Use of round and pointed laser applicator systems--initial results].
abstract: OBJECTIVE
  To assess the advantages and disadvantages by using round and sharp laser application systems during laser-induced thermotherapy.
  
  
  METHODS
  6 in vitro examinations were performed and 12 patients with liver metastases of colorectal carcinoma were treated with laser-induced thermotherapy. All lesions were closely localised to the diaphragm, liver capsule and large intrahepatic vessels. Five patients were treated with the sharp and 7 patients with the round applicator system. After CT-guided insertion of the catheter system into the metastasis laser therapy was performed under MRI control (approx. 25 W, 20 min).
  
  
  RESULTS
  Reduction of the distance between the laser applicator and rounded laser catheter tipp (approx. 0.5-1 cm) leads to better placement of the laser applicator in metastases located near the diaphragm, liver capsule and large intrahepatic vessels. Improved therapy results due to complete ablation of metastases were obtained. All patients treated with the round system had complete ablation of metastasis. In 3 of 5 patients treated with the sharp system, MRI control 2 days after therapy showed a residual tumour margin close to the diaphragm or to an intrahepatic vessel.
  
  
  CONCLUSIONS
  Improved ablation can be obtained by closer placement of a round laser catheter in liver metastasis located near the diaphragm, liver capsule and large intrahepatic vessels.
authors: Strahlenklinik, Virchow Klinikum. ralf.puls@charite.de
authors: R
authors: R
authors: Puls
authors: N
authors: N
authors: Hosten
authors: C
authors: C
authors: Stroszczynski
authors: R
authors: R
authors: Kreissig
authors: G
authors: G
authors: Gaffke
authors: R
authors: R
authors: Felix
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000628:therapy*; D002417:Cattle; D015179:Colorectal Neoplasms; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D066298:In Vitro Techniques; D053685:Laser Therapy; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013997:Time Factors