RANTES: a versatile and controversial chemokine.
The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.
Appay
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Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DS, Oxford, UK. vappay@gwmail.jr2.ox.ac.uk
Rowland-Jones
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D000595:Amino Acid Sequence; D000818:Animals; D018946:Chemokine CCL5 / Q000502:physiology*; D018925:Chemokines / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008958:Models, Molecular; D008969:Molecular Sequence Data
D018946:Chemokine CCL5; D018925:Chemokines