title: Quantitation of morphine and codeine in human urine using high-filed asymmetric waveform ion mobility spectrometry (FAIMS) with mass spectrometric detection.
abstract: Morphine and codeine have been identified and measured in a human urine matrix using high-field asymmetric waveform ion mobility spectrometry (FAIMS) in a tandem combination with electrospray ionization (ESI) and mass spectrometric (MS) detection. The addition of helium to the nitrogen carrier gas resulted in a substantial improvement in the sensitivity of the ESI-FAIMS-MS instrument for the determination of morphine and codeine. Limits of detection in human urine were 60 ng/mL for morphine and 20 ng/mL for codeine with no clean-up, derivatization, or chromatographic separation of the sample prior to analysis.
authors: Institute for National Measurement Standards, National Research Council of Canada, Ottawa, Ontario.
authors: M A
authors: MA
authors: McCooeye
authors: B
authors: B
authors: Ells
authors: D A
authors: DA
authors: Barnett
authors: R W
authors: RW
authors: Purves
authors: R
authors: R
authors: Guevremont
mesh_terms: D003061:Codeine / Q000652:urine*; D006801:Humans; D009020:Morphine / Q000652:urine*; D012680:Sensitivity and Specificity; D021241:Spectrometry, Mass, Electrospray Ionization / Q000295:instrumentation / Q000379:methods*
chemical_list: D009020:Morphine; D003061:Codeine