Benzyl tert-butoxycarbonyl-alpha-aminoisobutyrate.
The small synthetic peptide, benzyl 2-(tert-butoxycarbonyl-amino)isobutyrate, C(16)H(23)NO(4), has the alpha-helical conformation [/varphi/ = 55.8 (2) degrees and /psi/ = 37.9 (2) degrees] observed in peptide fragments of peptaibols containing the alpha-aminoisobutyric acid (Aib) residue. The structure shows no intramolecular hydrogen bonding, which would disrupt the limited conformational freedom associated with this amino acid. Two weak intermolecular hydrogen contacts are observed.
Leduc
A M
AM
Department of Chemistry, University of Louisville, Louisville, KY 40292, USA.
Mashuta
M S
MS
Spatola
A F
AF