Dementia with Lewy bodies in Down's syndrome.
The association between Down's syndrome (DS) and Alzheimer's disease is well established. This paper presents a review of the literature, suggesting a possible association between DS and the more recently recognised dementia with Lewy bodies (DLB). Patients with DLB frequently present with changes in affect and behaviour, and in particular with psychotic symptoms. The literature suggests a possible role for atypical neuroleptics in the management of psychosis in DLB.
Simard
M
M
Département de Psychologie, Université de Moncton, Moncton, Nouveau-Brunswick, Canada. simardm@umoncton.ca
van Reekum
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000453:epidemiology / Q000473:pathology / Q000523:psychology; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001569:Benzodiazepines; D015897:Comorbidity; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy; D004314:Down Syndrome / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology / Q000523:psychology; D006801:Humans; D020961:Lewy Body Disease / Q000188:drug therapy / Q000453:epidemiology* / Q000473:pathology / Q000523:psychology; D008875:Middle Aged; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
D014150:Antipsychotic Agents; D001569:Benzodiazepines; D000077152:Olanzapine; D010890:Pirenzepine; D017367:Selective Serotonin Reuptake Inhibitors