Pharmacokinetics of itraconazole oral solution in neutropenic children during long-term prophylaxis.
We investigated the pharmacokinetics and safety of an oral solution of itraconazole in two groups of neutropenic children stratified by age. Effective concentrations of itraconazole in plasma were reached quickly and maintained throughout treatment. The results indicate a trend toward higher concentrations of itraconazole in plasma in older children.
Schmitt
C
C
Hôpital d'Enfants, Vandoeuvre les Nancy, France.
Perel
Y
Y
Harousseau
J L
JL
Lemerle
S
S
Chwetzoff
E
E
le Moing
J P
JP
Levron
J C
JC
D000284:Administration, Oral; D019072:Antibiotic Prophylaxis; D000935:Antifungal Agents / Q000493:pharmacokinetics*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D017964:Itraconazole / Q000097:blood / Q000493:pharmacokinetics*; D008134:Long-Term Care; D009503:Neutropenia / Q000097:blood* / Q000378:metabolism
D000935:Antifungal Agents; D017964:Itraconazole