Targeting proteins to membranes, using signal sequences for lipid modifications.
Changing an existing lipid or appending a lipid to a cytosolic protein has emerged as an important technique for targeting proteins to membranes and for constitutively activating the membrane-bound protein. The potential for more precise or regulated interactions of lipidated proteins in membrane subdomains suggests that this method for membrane targeting will be of increasing usefulness.
Stickney
J T
JT
Department of Cell Biology, Neurobiology, and Anatomy, University of Cincinnati Medical Center, Cincinnati, Ohio 45267-0521, USA.
Booden
M A
MA
Buss
J E
JE
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001693:Biological Transport, Active; D019556:COS Cells; D017931:DNA Primers / Q000235:genetics; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008566:Membranes / Q000378:metabolism; D016133:Polymerase Chain Reaction; D011485:Protein Binding; D017368:Protein Prenylation; D021382:Protein Sorting Signals / Q000235:genetics; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*
D017931:DNA Primers; D008055:Lipids; D021382:Protein Sorting Signals; D011506:Proteins