[The development and application of a minitype multifunctional bio-impactor].
This study was aimed to develop a device that can be used for gas percussion, rigid impact, cell injury and simple estimation of the condition of injury. The device has been developed with the use of aerodynamical principle, measuring technique for feeble signal, and integration of machine-electricity. The gas percussion, rigid impact, and cell injury can be produced by altering impact tip. It was examined in the experimental researches of eye, brain, lung and cell injury; the parameters of causing injury could be controlled and on-line tested by the computer. The neurological states of pre- and post-injury were evaluated with the device. The results of animal experiments showed that mild, moderate and severe injury models were produced by gas pressure respectively. The pressure was 400, 600, 700 kPa for rats brain gas percussion injury, 600, 800, 1000 kPa for rabbits' retinal contusion, 300, 450, 600 kPa for rats' lung rigid impact injury, and 100, 150, 200 kPa for cultured cells' injury. In conclusion, the device is simple and easy to use for making controllable injury models, in which different parts and levels of injuries on different minitype animals can be reproduced.
Yin
Z
Z
Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042.
Wang
Z
Z
Liu
H
H
Xie
B
B
Wang
K
K
Dong
H
H
D000818:Animals; D004195:Disease Models, Animal; D004867:Equipment Design / Q000379:methods; D004864:Equipment and Supplies; D005260:Female; D008297:Male; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D014947:Wounds and Injuries / Q000209:etiology*