A topical mixture for preventing, abolishing, and treating autophagia and self-mutilation in laboratory rats.
The dysesthesia and paresthesia that occurs in laboratory rats after spinal cord injury and peripheral nerve injury results in autophagia and self-mutilation. This self-destructive behavior interferes with functional assessments in designed studies and jeopardizes the health of the injured rat. We developed a topical mixture that prevents, abolishes, and treats autophagia and self-mutilation. When the mixture is applied to the limb, its bitterness effectively prevents the rat from licking and biting the limb. In addition, the mixture has antiseptic properties.
Zhang
Y P
YP
Department of Neurological Surgery, University of Louisville, 210 East Gray Street, Suite 1102, Louisville, Kentucky 40202, USA.
Onifer
S M
SM
Burke
D A
DA
Shields
C B
CB
D000287:Administration, Topical; D000827:Animal Welfare; D000818:Animals; D005260:Female; D007608:Kainic Acid / Q000494:pharmacology; D008161:Lumbosacral Region / Q000293:injuries; D008795:Metronidazole / Q000008:administration & dosage; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012652:Self Mutilation / Q000517:prevention & control*; D017768:Skin, Artificial; D013119:Spinal Cord Injuries / Q000150:complications / Q000209:etiology
D004364:Pharmaceutical Preparations; D008795:Metronidazole; D007608:Kainic Acid