title: Transgenic mice with neuronal overexpression of bcl-2 gene present navigation disabilities in a water task.
abstract: In the CNS, Bcl-2 is an antiapoptotic gene involved in the regulation of neuronal death. Transgenic mice overexpressing the human gene Bcl-2 (Hu-bcl-2 mice) showed delayed acquisition in two tasks requiring them to find a hidden platform starting from either a random or a constant starting location. The same mice were not deficient in another task requiring them to find a visible platform suggesting that the delay observed was not due to motor, visual or motivational deficits in the water. The delay observed in Hu-bcl-2 mice was more important in the random starting test in which the allocentric demand for navigation was stronger. The results suggested that allocentric navigation is particularly sensitive to abnormal CNS maturation following the overexpression of the bcl-2 gene. The specific deficits (motor learning, fear-related behavior and allocentric navigation) observed in Hu-bcl-2 mice suggest that the regulation of developmental neuronal death is crucial for multisensorial learning and emotional behavior.
authors: Laboratoire Développement et Vieillissement du Système Nerveux, Institut des Neurosciences, CNRS UMR 7624, Université P&M Curie, 9 quai Saint-Bernard, 75005, Paris, France. laurerondi@yahoo.com
authors: L
authors: L
authors: Rondi-Reig
authors: Y
authors: Y
authors: Lemaigre-Dubreuil
authors: C
authors: C
authors: Montécot
authors: D
authors: D
authors: Müller
authors: J C
authors: JC
authors: Martinou
authors: J
authors: J
authors: Caston
authors: J
authors: J
authors: Mariani
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D001522:Behavior, Animal / Q000502:physiology; D002490:Central Nervous System / Q000254:growth & development* / Q000378:metabolism / Q000473:pathology; D018891:Dentate Gyrus / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D018507:Gene Expression Regulation, Developmental / Q000235:genetics; D019254:Genes, bcl-2 / Q000235:genetics*; D006624:Hippocampus / Q000254:growth & development / Q000378:metabolism / Q000473:pathology; D007859:Learning Disabilities / Q000235:genetics*; D017774:Long-Term Potentiation / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D009949:Orientation / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000235:genetics; D011930:Reaction Time / Q000235:genetics
chemical_list: D019253:Proto-Oncogene Proteins c-bcl-2