title: Synthesis of a new fluoro-Wang resin for solid-phase reaction monitoring by 19F NMR spectroscopy.
abstract: A new fluoro-Wang resin is presented which facilitates solid-phase reaction monitoring using 19F NMR. The resin is easily synthesized and amenable to scale-up. The method described herein compliments single-bead FT-IR and 13C NMR techniques. This method allows monitoring of solid-phase reactions even if the resin bound intermediate is unstable to the cleavage conditions. In addition, this is a useful tool to study reaction kinetics on the solid phase.
authors: Lead Discovery Department, Rhone Poulenc Rorer, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA.
authors: J M
authors: JM
authors: Salvino
authors: S
authors: S
authors: Patel
authors: M
authors: M
authors: Drew
authors: P
authors: P
authors: Krowlikowski
authors: E
authors: E
authors: Orton
authors: N V
authors: NV
authors: Kumar
authors: T
authors: T
authors: Caulfield
authors: R
authors: R
authors: Labaudiniere