Meal-related stimuli differentially induce c-Fos activation in the nucleus of the solitary tract.
Feedback signals arising from the oral cavity and upper gastrointestinal tract contribute to the control of meal size. To assess how these signals are integrated at central sites involved in ingestive control, we compared levels of c-Fos activation in the nucleus of the solitary tract (NTS) and area postrema (AP) in response to meal ingestion or gastric and duodenal infusions in the rat. Ingestion of a liquid diet to satiety induced significant fos-like immunoreactivity (FLI) at multiple levels of the NTS and within the AP. The restriction of intake to one-half the normal ingestion of a rat did not result in significant FLI, although gastric infusion of this liquid diet volume did. Fast bolus infusion resulted in greater FLI than did the same volume infused at a rate to mimic that of normal ingestion. Prior experience with gastric infusions did not affect the amounts of FLI within the NTS or AP. In rats with pyloric cuffs blocking flow from the stomach to the intestine, combined gastric load and duodenal nutrient elicited significantly greater FLI than either gastric or duodenal infusions alone. These data demonstrate that neural activation arising from meal-related stimuli are integrated at the level of the NTS.
Emond
M
M
Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Schwartz
G J
GJ
Moran
T H
TH
D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology; D002552:Cerebral Ventricles / Q000502:physiology; D004386:Duodenum / Q000502:physiology; D004435:Eating / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017552:Solitary Nucleus / Q000502:physiology*; D013270:Stomach / Q000502:physiology; D013997:Time Factors
D016760:Proto-Oncogene Proteins c-fos