Radiation-induced granulocyte transmigration predicts development of delayed structural changes in rat intestine.
We examined whether early radiation-induced granulocyte transmigration (assessed by the fecal transferrin excretion ELISA assay) predicts subsequent development of (consequential) chronic radiation enteropathy. After accounting for the effect of radiation dose, transferrin excretion remained an independent predictor of overall tissue injury, intestinal fibrosis, and mucosal ulcers, but not TGF-beta immunoreactivity.
Richter
K K
KK
Department of Surgery, University of Arkansas for Medical Sciences, and Central Arkansas Veterans Healthcare System, Little Rock, AR, USA.
Wang
J
J
Fagerhol
M K
MK
Hauer-Jensen
M
M
D000818:Animals; D002465:Cell Movement / Q000528:radiation effects*; D046508:Culture Techniques; D004195:Disease Models, Animal; D004307:Dose-Response Relationship, Radiation; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000737:chemistry*; D006098:Granulocytes / Q000528:radiation effects; D015601:Injury Severity Score; D007421:Intestine, Small / Q000528:radiation effects*; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011336:Probability; D012372:ROC Curve; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000473:pathology*; D051381:Rats; D012016:Reference Values; D014168:Transferrin / Q000032:analysis*; D016212:Transforming Growth Factor beta / Q000032:analysis*
D014168:Transferrin; D016212:Transforming Growth Factor beta