Immunomodulatory proteins of myxoma virus.
Poxviruses collectively encode an impressive collection of diverse immunomodulatory proteins. In this review we draw attention to some of the new open reading frames (ORFs) discovered during the sequencing of the myxoma virus DNA genome [Cameron C, Hota-Mitchell S, Chen L, Barrett J, Cao J-X, Macaulay C, Willer D, Evans D, McFadden G (1999) The complete DNA sequence of myxoma virus. Virology 264:298-318] that may function to subvert the host immune system. Most of these predicted functions are speculative but some of the deduced primary amino acid sequences contain intriguing similarities to known cellular and viral proteins in the public domain for which immunomodulatory functions have been assigned.
Barrett
J W
JW
John P. Robarts Research Institute, and Department of Microbiology and Immunology, The University of Western Ontario, 1400 Western Road, London, Ontario, N6G 2V4, Canada.
Cao
J X
JX
Hota-Mitchell
S
S
McFadden
G
G
D000276:Adjuvants, Immunologic / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D009233:Myxoma virus / Q000276:immunology*; D009234:Myxomatosis, Infectious / Q000276:immunology / Q000821:virology; D011213:Poxviridae Infections / Q000276:immunology / Q000821:virology; D014412:Tumor Virus Infections / Q000276:immunology / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology*
D000276:Adjuvants, Immunologic; D014764:Viral Proteins