Rapid detection of a common dihydropyrimidine dehydrogenase mutation associated with 5-fluorouracil toxicity and congenital thymine uraciluria using fluorogenic hybridization probes.
Nauck
M
M
Department of Clinical Chemistry, University Hospital, Hugstetter Strasse 55, 79106 iBr, Freiburg, Germany. msnauck@medl.ukl.uni-freiburg.de
Gierens
H
H
März
W
W
Wieland
H
H
D000483:Alleles; D000963:Antimetabolites / Q000494:pharmacology; D042943:Dihydrouracil Dehydrogenase (NADP); D005456:Fluorescent Dyes; D005472:Fluorouracil / Q000494:pharmacology*; D005838:Genotype; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D009693:Nucleic Acid Hybridization; D010088:Oxidoreductases / Q000235:genetics*; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA / Q000379:methods*; D013696:Temperature; D013941:Thymine / Q000652:urine*; D014498:Uracil / Q000652:urine*
D000963:Antimetabolites; D005456:Fluorescent Dyes; D014498:Uracil; D010088:Oxidoreductases; D042943:Dihydrouracil Dehydrogenase (NADP); D013941:Thymine; D005472:Fluorouracil