Superoxide scavenging activities of sixty Chinese medicines determined by an ESR spin-trapping method using electrogenerated superoxide.
Superoxide-scavenging activities of 60 kinds of Chinese herbal medicines were determined accurately by an electron spin resonance (ESR) spin-trapping technique using 5,5-dimethyl-1-pyrroline 1-oxide (DMPO) as a spin-trapping reagent. As a source of superoxide in this method, superoxide generated by one-electron reduction of the oxygen molecule in dimethyl sulfoxide solution was used. As a result of these studies, very powerful scavenging activity was found in Chinese medicines for inflammation, diseases of blood circulation and for tumors.
Liu
W
W
Graduate School of Science and Engineering, Yamagata University, Yonezawa 992-8510, Japan.
Ogata
T
T
Sato
S
S
Unoura
K
K
Onodera
J
J
D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D016166:Free Radical Scavengers; D013481:Superoxides
D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D013481:Superoxides