[Antioxidative homeostasis of critically ill individuals].
Content of primary and secondary products of lipid peroxidation; fat soluble vitamins: A, E, carotene, tocopherol's metabolites and total antioxidative activity were investigated in experiments with serum blood of donors and sick people with the acute surgical trauma. It was showed that during the critical states of sick people there is watched the strain of adaptive systems of the whole organism with the resource mobilisation of fat soluble vitamins and appearance of signs of their exhaustion, modification of the direction of metabolism of the unsaturated fat acids from certain formation of eicosanoids to the avalanche looking lipid peroxidation with the accumulation of poisonous products in blood. Also there intensify the formation of active tocopherol's metabolites, what is necessary for the re-establishment of the violative balance in the system of antioxidative protection.
Klymova
O M
OM
Kharkov State University, Ministry of Education of Ukraine.
Paranich
A V
AV
Voloshina
I Iu
IIu
Iefimova
N V
NV
Suprun
Iu A
IuA
D000208:Acute Disease; D000222:Adaptation, Physiological; D000975:Antioxidants / Q000378:metabolism*; D016638:Critical Illness; D006706:Homeostasis; D006801:Humans; D015227:Lipid Peroxidation; D013514:Surgical Procedures, Operative / Q000009:adverse effects; D024505:Tocopherols / Q000097:blood; D014815:Vitamins / Q000097:blood
D000975:Antioxidants; D014815:Vitamins; D024505:Tocopherols