Treatment of refractory microscopic colitis with azathioprine and 6-mercaptopurine.
Many patients with microscopic colitis will respond to antidiarrheal medications or to anti-inflammatory therapy with 5-aminosalicylates, although a few require corticosteroids. Some patients do not tolerate corticosteroid side effects, and a small subset are dependent on or refractory to corticosteroids. We report our experience with azathioprine and 6-mercaptopurine in patients with microscopic colitis.
Pardi
D S
DS
Division of Gastroenterology and Hepatology, Mayo Clinic and Foundation, Rochester, Minnesota, USA. pardi.darrell@mayo.edu
Loftus
E V
EV
Tremaine
W J
WJ
Sandborn
W J
WJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001379:Azathioprine / Q000009:adverse effects / Q000627:therapeutic use*; D003092:Colitis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D015122:Mercaptopurine / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged
D007166:Immunosuppressive Agents; D015122:Mercaptopurine; D001379:Azathioprine