Idiosyncratic rifabutin-induced leukopenia and SIADH: case report and review.
Rifabutin is increasingly critical for treatment of atypical mycobacterial infections. One of its serious adverse effects is leukopenia. When encountering rifabutin-induced leukopenia, clinicians are faced with the dilemma of whether to lower the dosage of rifabutin or discontinue it because existing literature does not indicate whether rifabutin-induced leukopenia is dose related or idiosyncratic. We report the first established case of idiosyncratic rifabutin-induced leukopenia in an immunocompetent man treated for pulmonary Mycobacterium avium complex infection. The patient also developed rifabutin-induced syndrome of inappropriate antidiuretic hormone (SIADH), which also has not been previously reported.
Chitre
M M
MM
School of Medicine, Division of Infectious Diseases, Veterans Affairs Western New York Healthcare System, Buffalo, NY 14215, USA.
Berenson
C S
CS
D000368:Aged; D000904:Antibiotics, Antitubercular / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000139:chemically induced*; D007970:Leukopenia / Q000139:chemically induced*; D008297:Male; D015269:Mycobacterium avium Complex / Q000302:isolation & purification*; D015270:Mycobacterium avium-intracellulare Infection / Q000000981:diagnostic imaging / Q000188:drug therapy*; D017828:Rifabutin / Q000009:adverse effects* / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
D000904:Antibiotics, Antitubercular; D017828:Rifabutin