title: RANTES: a versatile and controversial chemokine.
abstract: The activity of the chemokine RANTES is not restricted merely to chemotaxis. It is a powerful leukocyte activator, a feature potentially relevant in a range of inflammatory disorders. RANTES has attracted attention because it can potently suppress and, in some circumstances, enhance HIV replication. These characteristics are critically dependent on its ability to self-aggregate and bind to glycosaminoglycans.
authors: Human Immunology Unit, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DS, Oxford, UK. vappay@gwmail.jr2.ox.ac.uk
authors: V
authors: V
authors: Appay
authors: S L
authors: SL
authors: Rowland-Jones
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D018946:Chemokine CCL5 / Q000502:physiology*; D018925:Chemokines / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008958:Models, Molecular; D008969:Molecular Sequence Data
chemical_list: D018946:Chemokine CCL5; D018925:Chemokines