Transcription factors: bound to activate or repress.
The complex processes of eukaryotic gene expression are controlled by a relatively small number of transcription factors whose activities are modulated by a diverse set of regulatory mechanisms. A recent paper describes the molecular basis for one such mechanism in which the Pit-1 transcription factor activates or represses transcription depending on the sequence of the DNA to which it binds. The mechanism by which the binding-site sequence regulates the activity of Pit-1 is discussed in relation to that of other transcription factors.
Latchman
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D001665:Binding Sites; D004247:DNA / Q000378:metabolism; D005786:Gene Expression Regulation / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*
D014157:Transcription Factors; D004247:DNA