title: The rod photoreceptors in retinopathy of prematurity: an electroretinographic study.
abstract: OBJECTIVE
  To test the hypothesis that the more severe the acute phase retinopathy of prematurity (ROP) was in the preterm weeks, the more severely compromised is rod photoreceptor function after the ROP has resolved.
  
  
  METHODS
  Electroretinographic (ERG) responses were recorded from 25 dark-adapted children (ages 2.5 months' postterm to 14 years) categorized by maximum, acute phase ROP (None to Very Severe). From the ERG a-wave "S," a sensitivity parameter for the rod photoreceptor response, and R(mp3), the saturated amplitude of the rod photoreceptor response were calculated using a model of the activation of rod phototransduction. The patients' results were compared with those of healthy controls (n = 71).
  
  
  RESULTS
  Among those in the None, Mild, Moderate, and Severe categories, both S and R(mp3) varied significantly with severity of acute phase ROP. In the Very Severe category, ERG responses were too attenuated to calculate S and R(mp3).
  
  
  CONCLUSIONS
  The rod photoreceptors must be involved in ROP. The more severe the acute phase ROP, the more severe is the compromise of the processes involved in the activation of phototransduction in the rods.
authors: Department of Ophthalmology, Children's Hospital, 300 Longwood Ave, Boston, MA 02115, USA. fulton_a@a1.harvard.edu
authors: A B
authors: AB
authors: Fulton
authors: R M
authors: RM
authors: Hansen
authors: R A
authors: RA
authors: Petersen
authors: D K
authors: DK
authors: Vanderveen
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003623:Dark Adaptation; D004596:Electroretinography; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D017948:Retinal Rod Photoreceptor Cells / Q000503:physiopathology*; D012178:Retinopathy of Prematurity / Q000145:classification / Q000503:physiopathology*; D012684:Sensory Thresholds; D012720:Severity of Illness Index; D014792:Visual Acuity