title: Population-based incidence of pertussis among adolescents and adults, Minnesota, 1995-1996.
abstract: To estimate the incidence of pertussis, a prospective study was done among members of a managed care organization in Minneapolis/St. Paul, Minnesota. Of 212 patients 10-49 years old enrolled from January 1995 through December 1996, 8 were found to be culture positive, 10 were found to be positive by polymerase chain reaction assay, 13 had a > or =2-fold increase in IgG or IgA to pertussis toxin (PT), and 18 had IgG to PT in a single serum specimen > or =3 SD above the mean of an age-matched control group. At least 1 positive laboratory test result for pertussis infection was found in 27 (13%) patients, among whom the duration of cough illness was a median of 42 days (range, 27-66 days). On the basis of any positive laboratory result, the estimated annual incidence of pertussis was 507 cases per 100,000 person-years (95% confidence interval, 307-706 cases). Bordetella pertussis infection may be a more common cause of cough illness among adolescents and adults than was recognized previously.
authors: National Immunization Program, Centers for Disease Control and Prevention, Bldg. 12, Room 2223, Corporate Square Blvd., Atlanta, GA 30333, USA. pstrebel@cdc.gov
authors: P
authors: P
authors: Strebel
authors: J
authors: J
authors: Nordin
authors: K
authors: K
authors: Edwards
authors: J
authors: J
authors: Hunt
authors: J
authors: J
authors: Besser
authors: S
authors: S
authors: Burns
authors: G
authors: G
authors: Amundson
authors: A
authors: A
authors: Baughman
authors: W
authors: W
authors: Wattigney
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D001886:Bordetella pertussis / Q000276:immunology* / Q000302:isolation & purification; D002648:Child; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D037342:Pertussis Toxin; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D010566:Virulence Factors, Bordetella / Q000276:immunology; D014917:Whooping Cough / Q000453:epidemiology*
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D010566:Virulence Factors, Bordetella; D037342:Pertussis Toxin