Cytotoxic T cells and mycobacteria.
How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to enhance this.
Silva
C L
CL
Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. clsilva@fmrp.usp.br
Bonato
V L
VL
Lima
K M
KM
Coelho-Castelo
A A
AA
Faccioli
L H
LH
Sartori
A
A
De Souza
A O
AO
Leão
S C
SC
D000818:Animals; D001426:Bacterial Proteins; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D018834:Chaperonin 60; D018833:Chaperonins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008262:Macrophage Activation / Q000276:immunology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology*
D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D018834:Chaperonin 60; D019444:Vaccines, DNA; C074119:heat-shock protein 65, Mycobacterium; D018833:Chaperonins