Sarco(endo)plasmic reticulum calcium pumps: recent advances in our understanding of structure/function and biology (review).
This review examines the structure and function of the sarco(endo)plasmic reticulum calcium pump (SERCA1a) in the light of the recent publication of the 2.6 A resolution structure of this protein, and looks at the increasing awareness of the key role played by SERCAs in calcium signalling. The roles played by the calcium pump isoforms, SERCA1a/b, SERCA2a/b and SERCA3a/b/c in cellular function are discussed, and the modulation of SERCA activity by phospholamban, sarcolipin and other modulatory influences is examined. The recent discoveries of human SERCA mutations leading to disease states is reviewed, and the insights into SERCA function using transgenic approaches are outlined.
East
J M
JM
Division of Biochemistry and Molecular Biology, School of Biological Sciences, University of Southampton, UK. jme1@soton.ac.uk
D000818:Animals; D020013:Calcium Signaling; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D000252:Calcium-Transporting ATPases / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D004721:Endoplasmic Reticulum / Q000502:physiology*; D030342:Genetic Diseases, Inborn / Q000201:enzymology / Q000235:genetics; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008958:Models, Molecular; D009124:Muscle Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D009154:Mutation; D011510:Proteolipids / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000502:physiology*; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000099211:Phospholamban
D002135:Calcium-Binding Proteins; D000252:Calcium-Transporting ATPases; D009124:Muscle Proteins; D011510:Proteolipids; D053498:Sarcoplasmic Reticulum Calcium-Transporting ATPases; D000099211:Phospholamban; C077258:sarcolipin