title: Genotoxicity of dill (Anethum graveolens L.), peppermint (Menthaxpiperita L.) and pine (Pinus sylvestris L.) essential oils in human lymphocytes and Drosophila melanogaster.
abstract: Genotoxic properties of the essential oils extracted from dill (Anethum graveolens L.) herb and seeds, peppermint (Menthaxpiperita L.) herb and pine (Pinus sylvestris L.) needles were studied using chromosome aberration (CA) and sister chromatid exchange (SCE) tests in human lymphocytes in vitro, and Drosophila melanogaster somatic mutation and recombination test (SMART) in vivo. In the CA test, the most active essential oil was from dill seeds, then followed essential oils from dill herb, peppermint herb and pine needles, respectively. In the SCE test, the most active essential oils were from dill herb and seeds followed by essential oils from pine needles and peppermint herb. Essential oils from dill herb and seeds and pine needles induced CA and SCE in a clear dose-dependent manner, while peppermint essential oil induced SCE in a dose-independent manner. All essential oils were cytotoxic for human lymphocytes. In the SMART test, a dose-dependent increase in mutation frequency was observed for essential oils from pine and dill herb. Peppermint essential oil induced mutations in a dose-independent manner. Essential oil from dill seeds was almost inactive in the SMART test.
authors: Department of Botany and Genetics, Vilnius University, 21 Ciurlionis St, 2009, Vilnius, Lithuania. juozas.lazutka@gf.vu.lt
authors: J R
authors: JR
authors: Lazutka
authors: J
authors: J
authors: Mierauskiene
authors: G
authors: G
authors: Slapsyte
authors: V
authors: V
authors: Dedonyte
mesh_terms: D000818:Animals; D019661:Apiaceae; D002869:Chromosome Aberrations; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D036142:Mentha piperita; D009152:Mutagenicity Tests; D009154:Mutation; D009822:Oils, Volatile / Q000633:toxicity*; D041605:Pinus sylvestris; D010936:Plant Extracts / Q000633:toxicity; D010938:Plant Oils / Q000633:toxicity*; D012854:Sister Chromatid Exchange
chemical_list: D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils; C015424:peppermint oil