[Disorders of potassium metabolism in hemodialysis patients].
The fecal K concentration and the K-flux activity of erythrocytes were examined to investigate the role of extrarenal K excretion and K transport in peripheral tissue cells in hemodialysis patients. The fecal K concentration of hemodialysis patients was increased significantly(p < 0.01) compared to that of healthy subjects. The K-flux activity of erythrocytes and the serum K concentration correlated negatively(r = -0.482, p < 0.01) in non-diabetic hemodialysis patients, but did not correlate in diabetic hemodialysis patients. K-flux activity and Kt/V for urea correlated significantly(r = 0.412, p < 0.05). The K-flux activity of erythrocytes collected after hemodialysis therapy significantly increased (p < 0.05) compared with that of erythrocytes collected before therapy. We speculated that the K-flux activity of various cells including erythrocytes participates in the regulation of serum K in hemodialysis patients and that the inhibitory factors on K-flux activity are removed partially by hemodialysis therapy.
Ozawa
Y
Y
Department of Clinical Laboratory Medicine, Fukushima Medical University School of Medicine, Fukushima 960-1247.
Imafuku
Y
Y
Yoshida
H
H
Nishi
S
S
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004910:Erythrocyte Membrane / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005260:Female; D006801:Humans; D006947:Hyperkalemia / Q000209:etiology*; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood / Q000378:metabolism*; D006435:Renal Dialysis / Q000009:adverse effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000097:blood
D000254:Sodium-Potassium-Exchanging ATPase; D011188:Potassium