Retroviruses and autoimmunity.
The investigation of human retroviruses has shown dramatic progress since the discovery of human immunodeficiency virus (HIV). These studies have also contributed to the exploration of the role of retroviruses, including endogenous retroviruses, in the induction of autoimmune diseases such as systemic lupus erythematosus (SLE). This review describes the potential role of retroviruses in autoimmunity, based on recent findings including our own results.
Sekigawa
I
I
Department of Medicine, Juntendo University Izu-Nagaoka Hospital, Shizuoka.
Ogasawara
H
H
Kaneko
H
H
Hishikawa
T
T
Hashimoto
H
H
D001327:Autoimmune Diseases / Q000453:epidemiology / Q000209:etiology* / Q000276:immunology / Q000821:virology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology / Q000473:pathology; D015897:Comorbidity; D004279:DNA, Viral / Q000235:genetics; D020077:Endogenous Retroviruses / Q000235:genetics / Q000472:pathogenicity; D015752:Genes, env; D015750:Genes, gag; D015699:HIV Envelope Protein gp120 / Q000502:physiology; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology / Q000276:immunology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000453:epidemiology / Q000209:etiology / Q000276:immunology / Q000821:virology; D011533:Proviruses / Q000235:genetics; D012333:RNA, Messenger / Q000097:blood; D012367:RNA, Viral / Q000097:blood; D012190:Retroviridae / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D012192:Retroviridae Infections / Q000150:complications / Q000276:immunology*
D004279:DNA, Viral; D015699:HIV Envelope Protein gp120; D012333:RNA, Messenger; D012367:RNA, Viral