title: [Therapeutic monitoring by blood concentrations with the focus on cyclosporin A].
abstract: Cyclosporin A therapeutic drug monitoring with through concentrations results in a high frequency of toxicity or therapeutic failure. There is no simple relation between the through and the mean concentration, and thus the therapeutic effect. Estimation of the AUC on sparse sampling or population pharmacokinetic analysis and the Bayesian fit of the parameters are discussed.
authors: H:S Rigshospitalet, klinisk farmakologisk afdeling Q. sastrup@rh.dk
authors: S A
authors: SA
authors: Jensen
authors: K P
authors: KP
authors: Dalhoff
mesh_terms: D001499:Bayes Theorem; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine