title: New semisynthetic antimicrobial labdane-type diterpenoids derived from the resin "ladano" of Cistus creticus.
abstract: The antimicrobial activity of fifteen semisynthetic labdane-type diterpenes derived from the two major natural compounds 3 and 4 of the resin "ladano" of Cistus creticus is reported. The chloroethyl carbamidic esters 15 and 20 showed the strongest antimicrobial activity against Gram(+), Gram(-) bacteria and pathogenic fungi.
authors: Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, Athens, Greece.
authors: E
authors: E
authors: Kalpoutzakis
authors: N
authors: N
authors: Aligiannis
authors: S
authors: S
authors: Mitaku
authors: I
authors: I
authors: Chinou
authors: C
authors: C
authors: Harvala
authors: A L
authors: AL
authors: Skaltsounis
mesh_terms: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D006115:Greece; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D015394:Molecular Structure; D009284:Naphthols / Q000737:chemistry; D019685:Rosales / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D004224:Diterpenes; D009284:Naphthols; C089207:ent-8-hydroxylabda-13(16),14-diene