title: [An observational, retrospective two-year cost study in primary open-angle glaucoma and ocular hypertension in newly diagnosed patients].
abstract: OBJECTIVE
  To investigate the different treatment strategies in France and the direct costs for patients with newly diagnosed primary open-angle glaucoma or ocular hypertension who have started treatment with beta-blockers, and to estimate the total direct cost for two years of treat.
  
  
  METHODS
  and methods: We analyzed 225 medical charts retrospective in eleven academically and office-based centers in France over the first two years after diagnosis. Standard costs for each resource in current medical practice were determined from the French Social Security perspective.
  
  
  RESULTS
  The vast majority of patients (90%) had a diagnosis of primary, open-angle glaucoma or ocular hypertension in both eyes. In 60% of the patients we found a moderate or severe defect in their visual field or optic nerve. Intraocular pressure before treatment was 23.9+4.7mmHg and 17.5+4.2mmHg after two years of treatment. Over the first two years, 25% of visits led to a change in therapy (medical or surgical), involving 64% of the patients. Two-thirds of the changes occurred during the first year of treatment and in around 80% of cases for low intraocular pressure at check-up. Laser surgery or surgical intervention was performed in 25% of the patients. Total direct costs for two years were 5698F.F. The intraocular pressure before treatment was positively correlated (p<0.01) with treatment costs, while the initial intraocular pressure-lowering effects of treatment were negatively correlated with two-year costs.
  
  
  CONCLUSIONS
  After two years of treatment, the mean intraocular pressure decreased from 24 to 17.5mmHg. The higher the basal intraocular pressures is, the more intensive the treatment and the higher the costs. The more efficient the treatment to decrease baseline intraocular pressure is, the earlier the costs will be reduced.
authors: Service d'Ophtalmologie, CHRU, 12, avenue Oscar Lambret, 59037 Lille Cedex, France.
authors: J F
authors: JF
authors: Rouland
authors: G
authors: G
authors: Peigne
authors: E
authors: E
authors: Sellem
authors: J P
authors: JP
authors: Renard
authors: W
authors: W
authors: Williamson
authors: J M
authors: JM
authors: Filippi
authors: H
authors: H
authors: Cohn
authors: P
authors: P
authors: Hamard
authors: P
authors: P
authors: Abellan
authors: A
authors: A
authors: Chagnon
authors: F
authors: F
authors: Malet
authors: I
authors: I
authors: Haye
mesh_terms: D000368:Aged; D003365:Costs and Cost Analysis; D005260:Female; D005602:France; D005902:Glaucoma, Open-Angle / Q000175:diagnosis / Q000191:economics* / Q000601:surgery / Q000628:therapy; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D009798:Ocular Hypertension / Q000175:diagnosis / Q000191:economics* / Q000601:surgery / Q000628:therapy; D012044:Regression Analysis; D012189:Retrospective Studies; D012943:Social Security; D016019:Survival Analysis; D013997:Time Factors; D014794:Visual Fields