Cholinsalicylate gel induced oral lesion: report of case.
Salicylic acid and its derivatives are extensively used medications for the treatment of systemic and local diseases. However, injudicious use of aspirin as well as other derivatives of salicylic acid, may cause systemic and oral complications such as mucosal burns and oral ulcers. In children, topical administration of these drugs, even in small dosages, may cause adverse reactions. This report shows a case of an 8 year old boy with G6PD deficiency, who had a mucosal burn caused by application of a cholinsalicylate paste. Three days later, the child developed oral ulcers, malaise and fever. The present case is characteristic of the enigmatic nature of the etiology and diagnosis of oral lesions, and the possible connection between cholinsalicylate systemic absorption and hemolytic anemia is discussed.
Sapir
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Department of Pediatric Dentistry, Hadassah School of Dental Medicine, Faculty of Dentistry, Hebrew University, Jerusalem.
Bimstein
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D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D002057:Burns, Chemical / Q000209:etiology*; D002648:Child; D002794:Choline / Q000009:adverse effects* / Q000031:analogs & derivatives; D017742:Dental Care for Chronically Ill; D004338:Drug Combinations; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications; D006801:Humans; D008297:Male; D009061:Mouth Mucosa / Q000293:injuries*; D019226:Oral Ulcer / Q000209:etiology*; D012459:Salicylates / Q000009:adverse effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; D012459:Salicylates; C015075:choline salicylate; D002794:Choline