Treatment of refractory hand warts by isolated limb infusion with melphalan and actinomycin D.
We present an immunocompetent man with extensive warts on the hands, refractory to a number of conventional treatment modalities and causing substantial morbidity and impairment of normal function. Isolated limb infusion (regional intra-arterial chemotherapy) with melphalan and actinomycin D was performed, with substantial clearing of the warts within 2 months. Treatment-induced morbidity was limited to mild local erythema and oedema which resolved within 3 weeks. After 9 months' follow up, the patient had only a few residual warts and was able to resume normal activities.
Damian
D L
DL
Department of Medicine (Dermatology), University of Sydney, New South Wales, Australia.
Barnetson
R S
RS
Rose
B R
BR
Bonenkamp
J J
JJ
Thompson
J F
JF
D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage; D018906:Antineoplastic Agents, Alkylating / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D003609:Dactinomycin / Q000008:administration & dosage; D005500:Follow-Up Studies; D006229:Hand Dermatoses / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007121:Immunocompetence; D007261:Infusions, Intra-Arterial / Q000379:methods; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D012008:Recurrence; D012720:Severity of Illness Index; D016896:Treatment Outcome; D014860:Warts / Q000175:diagnosis / Q000188:drug therapy*
D000903:Antibiotics, Antineoplastic; D018906:Antineoplastic Agents, Alkylating; D003609:Dactinomycin; D008558:Melphalan