title: Feline hypertension: clinical findings and response to antihypertensive treatment in 30 cases.
abstract: Systolic hypertension was diagnosed in 30 cats. At diagnosis, 16 of those were found to be in chronic renal failure only, while five were azotaemic and either receiving treatment for hyperthyroidism (four cases) or were untreated hyperthyroid cases (one case). Two cases were untreated hyperthyroid cases with no evidence of azotaemia and the remaining seven cases had no definitive diagnosis of the underlying cause of their hypertension. The successful treatment used for the majority of cases was amlodipine, which lowered systolic blood pressure from 202.5+/-16.8 to 153.2+/-21.6 mmHg (mean+/-SD; n=29) within the first 50 days. Each case was followed for at least three months, or to the end of its natural life, and each cat was re-examined every six to eight weeks. Systolic blood pressure was kept below a target value of 165 mmHg in 58 per cent of cases treated for three months or longer. At the time of writing, 19 of the cases had died or been euthanased with a median treatment time of 203 days, one case was lost to follow-up and 10 cases were still alive, nine of which had been treated for six months or more. Amlodipine can be used for long-term control of feline systemic hypertension.
authors: Royal Veterinary College, London.
authors: J
authors: J
authors: Elliott
authors: P J
authors: PJ
authors: Barber
authors: H M
authors: HM
authors: Syme
authors: J M
authors: JM
authors: Rawlings
authors: P J
authors: PJ
authors: Markwell
mesh_terms: D017311:Amlodipine / Q000627:therapeutic use*; D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D018572:Disease-Free Survival; D005260:Female; D006973:Hypertension / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D017311:Amlodipine