[AmpC beta-lactamases producing bacteria].
beta-Lactamases are the principal mechanism of bacterial resistance to beta-lactam antibiotics. In recent years, resistance due to production of beta-lactamases including extended-spectrum beta-lactamses, carbapeneases and AmpC beta-lactamses, has risen at alarming rate in clinical isolates of gram-negative bacteria. AmpC beta-lactamses are classified by whether genes locate on chromosome or plasmid. The purpose of this paper is to address the general mechanism involve in AmpC beta-lactamase production and the clinical importance of the enzymes.
Okamoto
R
R
Department of Microbiology, Kitasato University School of Medicine.
Nakano
R
R
D001419:Bacteria / Q000187:drug effects / Q000201:enzymology*; D001426:Bacterial Proteins; D004352:Drug Resistance, Microbial; D001618:beta-Lactamases / Q000096:biosynthesis*
D001426:Bacterial Proteins; C048795:AmpC beta-lactamases; D001618:beta-Lactamases