Shared antigenicity between Helicobacter pylori and periodontopathic Campylobacter rectus strains.
Periodontopathic Campylobacter rectus strains possess 41- and 68-kDa proteinaceous antigens which share antigenicity with antigens of Helicobacter pylori strains. H. pylori strains have a 54-kDa antigen which reacts with C. rectus strains. We found that the salivary IgA levels against H. pylori were correlated with those against C. rectus. These cross-reactive antigens of C. rectus may affect the serological diagnosis of H. pylori infections, especially when saliva is used. It is possible that these cross-reacting antigens may relate to the induction of immunopathological responses against both microorganisms.
Ishihara
K
K
Department of Microbiology, Oral Science Center, Tokyo Dental College, Chiba, Japan. ishihara@tdc.ac.jp
Miura
T
T
Ebihara
Y
Y
Hirayama
T
T
Kamiya
S
S
Okuda
K
K
D000942:Antigens, Bacterial / Q000276:immunology*; D002167:Campylobacter / Q000276:immunology*; D002169:Campylobacter Infections / Q000382:microbiology; D003429:Cross Reactions; D016481:Helicobacter Infections / Q000382:microbiology; D016480:Helicobacter pylori / Q000276:immunology*; D006801:Humans; D015151:Immunoblotting; D007071:Immunoglobulin A, Secretory / Q000032:analysis / Q000276:immunology*; D010437:Peptic Ulcer / Q000382:microbiology; D010510:Periodontal Diseases / Q000382:microbiology; D012463:Saliva / Q000276:immunology
D000942:Antigens, Bacterial; D007071:Immunoglobulin A, Secretory