title: New glycosides from Capsicum annuum L. var. acuminatum. Isolation, structure determination, and biological activity.
abstract: Investigation of polar extracts from ripe fruits of Capsicum annuum L. var. acuminatum yielded three new glycosides, capsosides A (1) and B (2) and capsianoside VII (3), along with seven known compounds (4-10). The chemical structures were elucidated mainly by extensive nuclear magnetic resonance methods and mass spectrometry, and the biological activities of icariside E(5) (4) were tested by different assays. Icariside E(5), in contrast to capsaicin, neither induces an increase in the intracellular levels of reactive oxygen species nor affects the mitochondria permeability transition, and it does not signal through the vanilloid receptor type 1. Interestingly, this compound protects Jurkat cells from apoptosis induced by the oxidative stress mediated by serum withdrawal. These results suggest that icariside E(5) may have antioxidant properties that strengthen the importance of peppers in the Mediterranean diet.
authors: Dipartimento di Scienze e Tecnologie Agro-Alimentari, Ambientali e Microbiologiche, Università degli Studi del Molise, Via F. De Sanctis, I-86100 Campobasso, Italy. iorizzi@unimol.it
authors: M
authors: M
authors: Iorizzi
authors: V
authors: V
authors: Lanzotti
authors: S
authors: S
authors: De Marino
authors: F
authors: F
authors: Zollo
authors: M
authors: M
authors: Blanco-Molina
authors: A
authors: A
authors: Macho
authors: E
authors: E
authors: Muñoz
mesh_terms: D002212:Capsicum / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D017382:Reactive Oxygen Species
chemical_list: D006027:Glycosides; D010936:Plant Extracts; D017382:Reactive Oxygen Species