Genomic analysis and localization of murine Deltex, a modulator of notch activity, to mouse chromosome 5 and its human homolog to chromosome 12.
Deltex is a component of the Notch signaling network, which mediates cellular differentiation, proliferation, and apoptosis during development. Murine Deltex was initially isolated as a cDNA transcript that displayed increased expression in T-cell tumors induced by gamma irradiation. The in vivo function of Deltex is unknown; however, the emerging role of Notch signaling in T-cell development and lymphomagenesis indirectly supports a role for Deltex in these processes. To investigate the regulation of Deltex expression in both normal and transformed tissue, we have begun analyzing the Deltex genomic locus. Here, we report the exon-intron organization of Deltex and map the locus to the middistal region of mouse chromosome 5, tightly linked to the Adam1a, Lnk, Tbx5, and Nos1 loci. The human homolog of Deltex has been localized to chromosome 12.
Pampeno
C L
CL
Department of Pathology and Kaplan Cancer Center, New York University Medical School, New York, New York 10016, USA. pampec01@med.nyu.edu
Vallerie
A M
AM
Choi
J
J
Meruelo
N C
NC
Meruelo
D
D
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D051722:ADAM Proteins; D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D003001:Cloning, Molecular; D005091:Exons; D000072196:Fertilins; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007438:Introns; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics; D008565:Membrane Proteins / Q000378:metabolism; D008666:Metalloendopeptidases / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D019001:Nitric Oxide Synthase / Q000235:genetics; D052248:Nitric Oxide Synthase Type I; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D051880:Receptors, Notch; D017386:Sequence Homology, Amino Acid; D020825:T-Box Domain Proteins / Q000235:genetics
D020413:3' Untranslated Regions; D020121:5' Untranslated Regions; D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; C490777:Lnk protein, mouse; D008562:Membrane Glycoproteins; D008565:Membrane Proteins; D011506:Proteins; D051880:Receptors, Notch; C490778:SH2B3 protein, human; D020825:T-Box Domain Proteins; C103172:T-box transcription factor 5; C409218:deltex protein, vertebrate; C496320:NOS1 protein, human; D019001:Nitric Oxide Synthase; D052248:Nitric Oxide Synthase Type I; C496321:Nos1 protein, mouse; D051722:ADAM Proteins; C000606455:Adam1a protein, mouse; D000072196:Fertilins; D008666:Metalloendopeptidases