title: Frequency of cytochrome P450 2C9 mutant alleles in a Korean population.
abstract: OBJECTIVE
  To determine the frequencies of CYP2C9 variants in the Korean population and compare them with the frequencies in other ethnic populations.
  
  
  METHODS
  Genotyping of CYP2C9*2 and CYP2C9*3 allelic variants was carried out in 574 Korean subjects by PCR and restriction fragment length pattern analysis.
  
  
  RESULTS
  Thirteen of 574 subjects (2.3%) were heterozygous for CYP2C9*3 (Ile359Leu), but no subjects with a CYP2C9*2 allele or homozygous for CYP2C9*3 were identified. The allele frequency of CYP2C9*3 in Korean subjects (0.0113, 95% CI 0.0066-0.0193) was similar to that of other East Asian populations, but was considerably lower than that of Caucasian populations.
  
  
  CONCLUSIONS
  CYP2C9*3 seems to be an allelic variant related to the functional polymorphism of CYP2C9, but this variant is rarely seen among Koreans compared with Caucasians. Routine genotyping of the CYP2C9*2 allele is considered to be unnecessary in Korean and East Asians, because this allele appears to be extremely rare or absent in these populations.
authors: Department of Pharmacology, Inje University College of Medicine and Clinical Pharmacology Center, Pusan Paik Hospital, Korea.
authors: Y R
authors: YR
authors: Yoon
authors: J H
authors: JH
authors: Shon
authors: M K
authors: MK
authors: Kim
authors: Y C
authors: YC
authors: Lim
authors: H R
authors: HR
authors: Lee
authors: J Y
authors: JY
authors: Park
authors: I J
authors: IJ
authors: Cha
authors: J G
authors: JG
authors: Shin
mesh_terms: D001189:Aryl Hydrocarbon Hydroxylases; D065729:Cytochrome P-450 CYP2C9; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007723:Korea; D008297:Male; D009154:Mutation; D039181:Steroid 16-alpha-Hydroxylase; D013250:Steroid Hydroxylases / Q000235:genetics*
chemical_list: D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; C450260:CYP2C9 protein, human; D065729:Cytochrome P-450 CYP2C9; D001189:Aryl Hydrocarbon Hydroxylases; D039181:Steroid 16-alpha-Hydroxylase