Treatment of Vogt-Koyanagi- Harada's disease during pregnancy.
BACKGROUND
Caution should be exercised in treating patients with autoimmune diseases during pregnancy.


METHODS
We successfully treated three cases of Vogt-Koyanagi-Harada's disease (VKH disease) during pregnancy.


METHODS
In the second trimester (14-27 weeks) of 1 patient, inflammation was mild and could be treated by topical corticosteroid. There is the possibility that her immune response had been modified by pregnancy. Systemic corticosteroid in a high dose was administered to the two cases in the second and third trimesters of pregnancy (28-41 weeks). The severity of inflammation in these 2 patients was similar to that in nonpregnant women. Inflammation subsided immediately without recurrence in all cases. No abnormality was found during the deliveries or in the babies.


CONCLUSIONS
Treatment for VKH disease during pregnancy should be chosen according to the severity of inflammation, the stage of pregnancy, and the maternal and fetal conditions.
Miyata
N
N
Department of Ophthalmology, Yokohama City University School of Medicine, Yokahama, Japan.
Sugita
M
M
Nakamura
S
S
Isobe
K
K
Matoba
H
H
Tsuda
K
K
Tanaka
K
K
Ohno
S
S
D000328:Adult; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D005865:Gestational Age; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007262:Infusions, Intravenous; D011239:Prednisolone / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis / Q000188:drug therapy*; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis / Q000188:drug therapy*
D005938:Glucocorticoids; D011239:Prednisolone