[Dedifferentiation of mature teratomas secondary to testicular cancer: report of 2 cases].
The authors report two cases of adenocarcinomatous dedifferentiation of a recurrent mature teratoma arising 3 and 20 years after the initial resection. This is a rare event, occurring after macroscopically or microscopically incomplete resection of a mature teratoma. The nature of this recurrence was difficult to determine prior to histological examination. However, PET scan suggests the diagnosis of malignant teratoma in the presence of increased uptake by the lesion. These tumours have a poor prognosis. Treatment consists of complete resection of the tumour mass. The possibility of long-term malignant dedifferentiation of a teratoma therefore requires prolonged and regular life-long surveillance of patients presenting a mature teratoma after chemotherapy for non-seminomatous germ cell tumour of the testis.
Game
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X
Service de Chirurgie viscérale et vasculaire, Hôpital d'Instruction des Armées du Val de Grâce, 74, Boulevard de Port-Royal, 75230, Paris.
Houlgatte
A
A
Fournier
R
R
Duhamel
P
P
Baranger
B
B
Khoury
S
S
D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000473:pathology*; D012186:Retroperitoneal Neoplasms / Q000473:pathology*; D013724:Teratoma / Q000473:pathology*; D013736:Testicular Neoplasms / Q000601:surgery*