An elevation in the concentration of HLA class I molecules in human blood due to ageing.
The quantification of plasmatic HLA class-I molecules (sHLA-I) was realized by a sandwich ELISA using a monomorphic mAb (W6/32). sHLA-I concentration is significantly increased in the elderly group (>50 years, 0.429+/-0.301 microg ml(-1)) as compared to the young group (<50 years, 0.126+/-0.085 microg ml(-1)). The variation of sHLA-I content could contribute to the unresponsiveness of ageing immune system.
Le Morvan
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Laboratoire d'Immunologie et Immunogénétique UMR 6101, Faculté de Médecine, 2, rue du Docteur Marcland, 87025 Limoges, France.
Cogné
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Drouet
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D000375:Aging / Q000097:blood / Q000276:immunology*; D006680:HLA Antigens / Q000097:blood*; D015395:Histocompatibility Antigens Class I / Q000097:blood*; D006801:Humans
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I