alpha-synuclein immunopositive Parkinson's disease-related inclusion bodies in lower brain stem nuclei.
Advanced silver stains and immunohistochemical reactions against alpha-synuclein were used to detect Parkinson's disease-related cytoskeletal abnormalities in select lower brain stem nuclei. Various types of inclusion bodies including inconspicuous and heretofore unnoted granular particles and thread-like Lewy neurites were visualized. Of the nuclei investigated (gigantocellular reticular nucleus, bulbar raphe nuclei, coeruleus-subcoeruleus area), only lipofuscin- or neuromelanin-laden neuronal types showed a propensity to develop the pathological changes. Neuronal types devoid of pigment deposits remained free of the cytoskeletal abnormalities. Fine, dust-like particles and small globular Lewy bodies were encountered solely within the limits of intraneuronal lipofuscin or neuromelanin deposits.
Braak
E
E
Department of Anatomy, J. W. Goethe-University, Theodor Stern Kai 7, 60590 Frankfurt/Main, Germany. Braak@em.uni-frankfurt.de
Sandmann-Keil
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D
Rüb
U
U
Gai
W P
WP
de Vos
R A
RA
Steur
E N
EN
Arai
K
K
Braak
H
H
D000368:Aged; D003599:Cytoskeleton / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism / Q000473:pathology*; D016631:Lewy Bodies / Q000378:metabolism / Q000473:pathology; D008062:Lipofuscin / Q000378:metabolism; D008125:Locus Coeruleus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D016501:Neurites / Q000378:metabolism / Q000473:pathology; D009474:Neurons / Q000378:metabolism / Q000473:pathology*; D010300:Parkinson Disease / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D010858:Pigmentation / Q000502:physiology; D011903:Raphe Nuclei / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012154:Reticular Formation / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D012249:Rhombencephalon / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D051843:Synucleins; D051844:alpha-Synuclein
D008062:Lipofuscin; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein