The caveolin triad: caveolae biogenesis, cholesterol trafficking, and signal transduction.
Caveolins are a family of proteins that coat the cytoplasmic face of caveolae, vesicular invaginations of the plasma membrane. These proteins are central to the organization of the proteins and lipids that reside in caveolae. Caveolins transport cholesterol to and from caveolae, and they regulate the activity of signaling proteins that reside in caveolae. Through studying the genes encoding the caveolae coat proteins, we have learned much about how they perform these multiple functions.
Schlegel
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Department of Molecular Pharmacology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA.
Lisanti
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D000595:Amino Acid Sequence; D000818:Animals; D001692:Biological Transport; D021941:Caveolae / Q000502:physiology*; D051242:Caveolin 1; D051244:Caveolin 3; D022461:Caveolins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D008969:Molecular Sequence Data; D009136:Muscular Dystrophies / Q000235:genetics / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction
C495540:CAV1 protein, human; D051242:Caveolin 1; D051244:Caveolin 3; D022461:Caveolins; D002784:Cholesterol