Life and death in the JUNgle.
Experiments with transgenic and knockout mice have begun to elucidate distinct roles for the three members of the Jun family of transcription factors. Mice with tissue-specific loss of JunB develop a myeloproliferative disorder, emphasizing the important roles that Jun proteins play in regulating life and death decisions in disease.
Weitzman
J B
JB
Unité des Virus Oncogènes, Pasteur Institute, 25 Rue du Dr Roux, Paris, France. jonny@pasteur.fr
D000818:Animals; D017209:Apoptosis; D002455:Cell Division; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008954:Models, Biological; D009196:Myeloproliferative Disorders / Q000378:metabolism*; D011485:Protein Binding; D016755:Proto-Oncogene Proteins c-jun / Q000502:physiology*
D016755:Proto-Oncogene Proteins c-jun