Attenuation of infarct size in rats and dogs after myocardial infarction by low-energy laser irradiation.
OBJECTIVE
The aim of the present study was to investigate the possibility that low-energy laser irradiation attenuates infarct size formation after induction of chronic myocardial infarction (MI) in small and large experimental animals.


METHODS
Laser irradiation was applied to the infarcted area of rats and dogs at various power densities (2.5 to 20 mW/cm(2)) after occlusion of the coronary artery.


RESULTS
In infarcted laser-irradiated rats that received laser irradiation immediately and 3 days after MI at energy densities of 2.5, 6, and 20 mW/cm(2), there was a 14%, 62% (significant; P < 0.05), and 2.8% reduction of infarct size (14 days after MI) relative to non--laser-irradiated rats, respectively. In dogs, a 49% (significant; P < 0.01) reduction of infarct size was achieved.


CONCLUSIONS
The results of the present study indicate that delivery of low-energy laser irradiation to infarcted myocardium in rats and dogs has a profound effect on the infarct size after MI.
Oron
U
U
Department of Zoology, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel. oronu@post.tau.ac.il
Yaakobi
T
T
Oron
A
A
Hayam
G
G
Gepstein
L
L
Rubin
O
O
Wolf
T
T
Ben Haim
S
S
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology* / Q000601:surgery*; D011336:Probability; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012680:Sensitivity and Specificity