Effect of imaging time on gallium renal scan.
OBJECTIVE
Gallium renal imaging has been reported to be useful in monitoring disease activity and predicting the response to therapy in lupus nephritis. Gallium renal images are usually obtained 48 h after the injection of 67Ga citrate, but 72-h images sometimes are the only available pictures. The aim of the present study was to determine whether the time intervals from injection to imaging had any effect on the grading of gallium renal scintigraphy.


METHODS
Fifty-five patients with lupus nephritis underwent gallium renal imaging at both 48 h and 72 h post-injection of 111 MBq of 67Ga citrate. The relative uptakes of 67Ga by the kidneys and the spine was judged visually on the analog images. Renal uptake was rated on a scale of 0-3.


RESULTS
Fifty-three patients (96.3%) had the same grading of renal uptake in the 48-h and the 72-h images. Only two patients (3.7%) had a different grading in the 72-h images when compared to the 48-h images. The correlation between the 48-h renal uptake and 72-h renal uptake was excellent, with a Spearman R value of 0.94. No significant difference was noted between these two groups, with a P value of 0.76 (using a Wilcoxon matched pairs test).


CONCLUSIONS
A gallium renal scan can be obtained either 48 h or 72 h after injecting 67Ga citrate. The imaging time did not interfere with the grading of renal uptake in lupus nephritis.
Hsieh
J F
JF
Chi-Mei Foundation Hospital, Yunk Kang City, Tainan, Taiwan.
Tsai
S C
SC
Cheng
K Y
KY
Lin
W Y
WY
Wang
S J
SJ
D000328:Adult; D001692:Biological Transport; D002951:Citrates / Q000493:pharmacokinetics; D005260:Female; D005708:Gallium / Q000493:pharmacokinetics; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008181:Lupus Nephritis / Q000000981:diagnostic imaging* / Q000503:physiopathology*; D008297:Male; D008991:Monitoring, Physiologic / Q000379:methods; D011877:Radionuclide Imaging / Q000379:methods; D013131:Spine / Q000000981:diagnostic imaging / Q000378:metabolism; D013997:Time Factors
D002951:Citrates; D005710:Gallium Radioisotopes; D005708:Gallium; C103850:gallium citrate