Activity modulates neuronal proliferation in the developing olfactory epithelium.
The present experiment demonstrates that environmental stimulation can activate neurogenesis within olfactory mucosae exhibiting depressed proliferation. Rats underwent naris occlusion on P1 with plugs that were removed 20 days later. Normal respiration induced a sharp increase in proliferating neuronal precursors within 24-48 h, and epithelial depth was restored within 5 days.
Mirich
J M
JM
Department of Psychology, University of Virginia, Charlottesville, VA 22904, USA.
Brunjes
P C
PC
D000818:Animals; D002455:Cell Division / Q000502:physiology; D018034:Olfactory Receptor Neurons / Q000166:cytology* / Q000254:growth & development / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D012683:Sensory Deprivation / Q000502:physiology; D012903:Smell / Q000502:physiology*