title: Effects of bupropion SR on anterior paralimbic function during waking and REM sleep in depression: preliminary findings using.
abstract: This study sought to clarify the effects of bupropion SR on anterior paralimbic function in depressed patients by studying changes in the activation of these structures from waking to REM sleep both before and after treatment. Twelve depressed patients underwent concurrent EEG sleep studies and [18F]fluoro-2-deoxy-D-glucose ([18F]-FDG) positron emission tomography (PET) scans during waking and during their second REM period of sleep before and after treatment with bupropion SR. Nine subjects completed pre- and post-treatment waking PET studies. Five subjects completed pre- and post-treatment waking and REM sleep PET studies. Bupropion SR treatment did not suppress electrophysiologic measures of REM sleep, nor did it alter an indirect measure of global metabolism during either waking or REM sleep. Bupropion SR treatment reversed the previously observed deficit in anterior cingulate, medial prefrontal cortex and right anterior insula activation from waking to REM sleep. In secondary analyses, this effect was related to a reduction in waking relative metabolism in these structures following treatment in the absence of a significant effect on REM sleep relative metabolism. The implications of these findings for the relative importance of anterior paralimbic function in REM sleep in depression and for the differential effects of anti-depressant treatment on brain function during waking vs. REM sleep are discussed.
authors: Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA. nofzingerea@msx.upmc.edu
authors: E A
authors: EA
authors: Nofzinger
authors: S
authors: S
authors: Berman
authors: A
authors: A
authors: Fasiczka
authors: J M
authors: JM
authors: Miewald
authors: C C
authors: CC
authors: Meltzer
authors: J C
authors: JC
authors: Price
authors: R C
authors: RC
authors: Sembrat
authors: A
authors: A
authors: Wood
authors: M E
authors: ME
authors: Thase
mesh_terms: D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000378:metabolism*; D016642:Bupropion / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D003865:Major Depressive Disorder / Q000188:drug therapy*; D004569:Electroencephalography; D005260:Female; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006179:Gyrus Cinguli / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D008032:Limbic System / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D008297:Male; D017397:Prefrontal Cortex / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012895:Sleep, REM / Q000187:drug effects*; D014851:Wakefulness / Q000187:drug effects*
chemical_list: D003692:Delayed-Action Preparations; D019275:Radiopharmaceuticals; D016642:Bupropion; D019788:Fluorodeoxyglucose F18; D005947:Glucose