Plasminogen-activator-inhibitor-1 4G/5G promoter polymorphism and prognosis of severely injured patients.
A single base pair insertion/deletion (4G/SG) promoter polymorphism in the plasminogen-activator-inhibitor-1 (PAI-1) gene is thought to play a part in prognosis after severe trauma. We investigated the relation between outcome of severe trauma, PAI-1 concentrations, and PAP-1 genotype in 61 patients who had been severely injured. 11 (58%) of 19 patients with genotype 4G/4G did not survive, whereas only eight (28%) of 29 patients with heterozygous genotype 4G/SG, and two (15%) of 13 patients with genotype 5G/5G died. The PAI-1 4G allele is associated with high concentrations of PAI-1 in plasma and a poor survival rate after severe trauma.
Menges
T
T
Hermans
P W
PW
Little
S G
SG
Langefeld
T
T
Böning
O
O
Engel
J
J
Sluijter
M
M
de Groot
R
R
Hempelmann
G
G
D000483:Alleles; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D009102:Multiple Organ Failure / Q000235:genetics / Q000401:mortality; D000073718:Pancreatitis-Associated Proteins; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000235:genetics*; D017354:Point Mutation; D011110:Polymorphism, Genetic; D011379:Prognosis; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012307:Risk Factors; D018805:Sepsis / Q000235:genetics / Q000401:mortality; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014947:Wounds and Injuries / Q000097:blood / Q000235:genetics / Q000401:mortality*
D007375:Interleukin-1; D000073718:Pancreatitis-Associated Proteins; D017395:Plasminogen Activator Inhibitor 1; C000612141:REG3A protein, human; D014409:Tumor Necrosis Factor-alpha