title: Recurrence of curetted and bone-grafted giant-cell tumours with and without adjuvant phenol therapy.
abstract: OBJECTIVE
  Giant-cell tumour of bone (GCT) represents 5% of all primary bone tumours. The aim of this study was to compare the outcome of GCT treated with or without phenol.
  
  
  METHODS
  Out of 53 patients primarily treated for a giant-cell tumour, 47 were followed, with a median follow-up of 11 (range 4-43) years. All patients were disease-free at the latest follow-up. Of the 40 tumours (85%) located in long bones, 14 (35%) were treated by curettage and bone grafting and 12 (30%) by additional adjuvant phenol treatment. Fourteen patients (35%) received different therapies, including en-bloc resection, endoprosthesis, cement packing or other therapy.
  
  
  RESULTS
  There were seven (17.5%) recurrences in long bones after a median of 12 (range 4-60) months, three (3/14, 21%) in the group treated without phenol and three (3/12, 25%) in the group with phenol. Of the seven tumours located in the axial skeleton, two patients died within the first year after surgery. The remaining five patients were followed, with a median follow-up of 12 (range 8-23) years. No patients had metastases or a multicentric tumour.
  
  
  CONCLUSIONS
  Despite the different rates of recurrence reported in literature, this study suggests that local recurrence rate of giant-cell tumours located in long bones treated with or without phenol is similar. Adequate removal of the tumour seems to be a more important predictive factor for the outcome of surgery than the use of phenol as an adjuvant therapy.
authors: Department of Orthopaedics, University of Vienna, Vienna, Austria. Klemens.trieb@akh-wien.ac.at
authors: K
authors: K
authors: Trieb
authors: P
authors: P
authors: Bitzan
authors: S
authors: S
authors: Lang
authors: M
authors: M
authors: Dominkus
authors: R
authors: R
authors: Kotz
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D016025:Bone Transplantation; D017024:Chemotherapy, Adjuvant; D002648:Child; D003475:Curettage; D005260:Female; D018212:Giant Cell Tumor of Bone / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D019800:Phenol / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D019800:Phenol