A tale of histone modifications.
The modification of chromatin structure is important for a number of nuclear functions, exemplified by the regulation of transcription. This review discusses recent studies of covalent histone modifications and the enzymatic machines that generate them.
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Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Jefferson Park Avenue, Charlottesville, VA 22908, USA. pag9n@virginia.edu
D000107:Acetylation; D000123:Acetyltransferases / Q000378:metabolism; D000818:Animals; D002843:Chromatin / Q000378:metabolism; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases / Q000378:metabolism; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008780:Methyltransferases / Q000378:metabolism; D010766:Phosphorylation; D029701:Saccharomyces cerevisiae Proteins
D002843:Chromatin; D006657:Histones; D029701:Saccharomyces cerevisiae Proteins; D008780:Methyltransferases; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D006655:Histone Deacetylases