Notch pathway: making sense of suppressor of hairless.
Suppressor of Hairless (Su(H)) is a DNA-binding protein component of the Notch signalling pathway, thought to be required, with a fragment of the Notch receptor, for target gene activation. Recent studies show that this is only one side of the story: target gene enhancers may be regulated by Su(H) in a variety of different ways.
Bray
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Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK. sjb32@mole.bio.cam.ac.uk
Furriols
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D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D029721:Drosophila Proteins; D004742:Enhancer Elements, Genetic; D005786:Gene Expression Regulation; D018257:Helix-Loop-Helix Motifs; D019476:Insect Proteins / Q000235:genetics; D008565:Membrane Proteins / Q000378:metabolism*; D009687:Nuclear Proteins / Q000235:genetics; D051880:Receptors, Notch; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D015533:Transcriptional Activation
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D009687:Nuclear Proteins; D051880:Receptors, Notch; D012097:Repressor Proteins; C084530:E(spl)mdelta-HLH protein, Drosophila; C088731:Su(H) protein, Drosophila; C089449:sim protein, Drosophila; C095064:vg protein, Drosophila