Genotoxic effect of hydroquinone on the cultured mouse spleenocytes.
The daily administration of 0, 0.5, 1, 2, 4 and 8 mg/kg b. wt. of hydroquinone (HQ) to Swiss albino mice, consecutively for 6 days resulted in a dose dependent elevation in the frequency of micronucleated binucleate spleenocytes (MNBNS). This increase in the frequency of MNBNS was significantly higher than that of non-drug treated controls (0 mg/kg). The daily administration of various doses of HQ for 6 days not only increased the frequency of binucleated spleenocytes bearing one micronuclei (MN), but also the BNS bearing two, three, and four MN. The study demonstrates that the daily administration of various doses of HQ for 6 days increases the genotoxic and mutagenic potential in mice.
Jagetia
G C
GC
Department of Radiobiology, Kasturba Medical College, 3rd Floor, Karnataka, 576 119, Manipal, India. jagetia-vip@zetainfotech.com
Menon
K S
KS
Jain
V
V
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002478:Cells, Cultured; D006873:Hydroquinones / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects
D006873:Hydroquinones; D009153:Mutagens