No evidence of an association between CYP2D6 polymorphisms among Japanese and dementia with Lewy bodies.
Dementia with Lewy bodies (DLB) is the second most frequent degenerative dementia among the elderly, following Alzheimer-type dementia (ATD). An association of DLB with CYP2D6*4, one of the cytochrome P450IID6 (debrisoquine 4-hydroxylase; CYP2D6) gene polymorphisms, was reported previously, but this is controversial. Moreover, these reports have been restricted to Caucasian populations. Therefore, we compared frequencies of CYP2D6*3, *4, and *10 mutant alleles in 17 Japanese DLB patients to those among Alzheimer-type dementia (ATD) patients and healthy controls. Polymerase chain reaction amplification and restriction fragment length polymorphism analyses were used for genotyping. No significant difference of genotype or mutant allele frequencies was detected between DLB, ATD, and healthy controls. The present results do not support the suggestion that the CYP2D6 gene is related to DLB susceptibility, at least in the Japanese population.
Furuno
T
T
Department of Psychiatry, Yokohama City University, School of Medicine, Yokohama and Numazu Central Hospital, Numazu, Japan. tfuruno@med.yokohama-cu.ac.jp
Kawanishi
C
C
Iseki
E
E
Onishi
H
H
Sugiyama
N
N
Suzuki
K
K
Kosaka
K
K
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics; D046508:Culture Techniques; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D020961:Lewy Body Disease / Q000453:epidemiology / Q000235:genetics*; D008297:Male; D012150:Polymorphism, Restriction Fragment Length
D019389:Cytochrome P-450 CYP2D6