Extension of life-span by loss of CHICO, a Drosophila insulin receptor substrate protein.
The Drosophila melanogaster gene chico encodes an insulin receptor substrate that functions in an insulin/insulin-like growth factor (IGF) signaling pathway. In the nematode Caenorhabditis elegans, insulin/IGF signaling regulates adult longevity. We found that mutation of chico extends fruit fly median life-span by up to 48% in homozygotes and 36% in heterozygotes. Extension of life-span was not a result of impaired oogenesis in chico females, nor was it consistently correlated with increased stress resistance. The dwarf phenotype of chico homozygotes was also unnecessary for extension of life-span. The role of insulin/IGF signaling in regulating animal aging is therefore evolutionarily conserved.
Clancy
D J
DJ
Department of Biology, University College London, Wolfson House, 4 Stephenson Way, London NW1 2HE, UK.
Gems
D
D
Harshman
L G
LG
Oldham
S
S
Stocker
H
H
Hafen
E
E
Leevers
S J
SJ
Partridge
L
L
D000375:Aging / Q000502:physiology*; D000483:Alleles; D000818:Animals; D001824:Body Constitution; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism; D003433:Crosses, Genetic; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000502:physiology*; D005260:Female; D005298:Fertility; D017344:Genes, Insect; D006579:Heterozygote; D006358:Hot Temperature; D019476:Insect Proteins / Q000235:genetics* / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D055504:Insulin Receptor Substrate Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008136:Longevity / Q000502:physiology*; D008297:Male; D009154:Mutation; D018384:Oxidative Stress; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases; D011972:Receptor, Insulin / Q000378:metabolism*; D012098:Reproduction; D015398:Signal Transduction; D013002:Somatomedins / Q000378:metabolism; D013217:Starvation; D013482:Superoxide Dismutase
D002352:Carrier Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D007328:Insulin; D055504:Insulin Receptor Substrate Proteins; D047908:Intracellular Signaling Peptides and Proteins; D013002:Somatomedins; C120233:chico protein, Drosophila; D013482:Superoxide Dismutase; C094982:InR protein, Drosophila; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; D011972:Receptor, Insulin