title: Symptomatic treatment of premenstrual mastalgia in premenopausal women with lisuride maleate: a double-blind placebo-controlled randomized study.
abstract: OBJECTIVE
  To determine the therapeutic effect of lisuride maleate on premenstrual mastalgia in premenopausal women.
  
  
  METHODS
  Double-blind randomized prospective study.
  
  
  METHODS
  Department of obstetrics and gynecology at a university hospital.
  
  
  METHODS
  Sixty women with premenstrual mastalgia were included in the study. Study and control groups consisted of 30 women each.
  
  
  METHODS
  Women enrolled in the study and control group were given one tablet daily (0.2 mg) of lisuride maleate or placebo orally for 2 months. Severity of mastalgia was evaluated using the visual analog scale.
  
  
  METHODS
  Severity of mastalgia and side effects of the drug administered.
  
  
  RESULTS
  Mastalgia subsided significantly in women receiving lisuride maleate compared with controls. There were no significant side effects from lisuride maleate. Prolactin levels decreased significantly in the group receiving lisuride, which correlated well with pain resolution.
  
  
  CONCLUSIONS
  Lisuride maleate may be useful for the symptomatic treatment of premenstrual mastalgia.
authors: Istanbul University, Cerrahpaşa Medical Faculty, Department of Obstetrics and Gynecology, Istanbul, Turkey. semikhaleli@yahoo.com
authors: S
authors: S
authors: Kaleli
authors: Y
authors: Y
authors: Aydin
authors: C T
authors: CT
authors: Erel
authors: U
authors: U
authors: Colgar
mesh_terms: D000328:Adult; D001941:Breast Diseases / Q000209:etiology / Q000517:prevention & control; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008090:Lisuride / Q000627:therapeutic use*; D008875:Middle Aged; D010146:Pain / Q000209:etiology / Q000517:prevention & control*; D010147:Pain Measurement; D010919:Placebos; D011293:Premenstrual Syndrome / Q000188:drug therapy*
chemical_list: D018491:Dopamine Agonists; D010919:Placebos; D008090:Lisuride