title: Study on the lubrication mechanism of natural joints by confocal laser scanning microscopy.
abstract: Natural joints have an excellent lubricating function, but the detailed mechanism is still unclear. To clarify this lubricating mechanism, we observed the behavior of the cartilage surface under the physiological loading condition with confocal laser scanning microscopy in normal and osteoarthritis (OA) cartilage rabbit specimens. Even with a considerable loading condition, in both natural and OA cartilage, the fluid pool area coexisted with the direct contact area. In the junction from the direct contact area to the fluid area, there was a third area with a liquid-crystal arrangement. In OA cartilage, these areas were generally irregular and small. These results suggest that a lubrication system in the fluid phase, such as squeeze film lubrication, might work under severe pressure in normal cartilage, and hyaluronic acid macromolecules in the synovial fluid might form a liquid-crystal structure and support pressure on the cartilage surface, whereas these systems did not affect the OA cartilage.
authors: Department of Tissue Regeneration, Institute for Frontier Medical Science, Kyoto University, Kawahara-cho, Shogoin, Sakyo-ku, Kyoto, Japan.
authors: M
authors: M
authors: Kobayashi
authors: J
authors: J
authors: Toguchida
authors: M
authors: M
authors: Oka
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D002356:Cartilage; D007596:Joints; D011817:Rabbits; D013499:Surface Properties; D013582:Synovial Fluid