Nicastrin, a presenilin-interacting protein, contains an aminopeptidase/transferrin receptor superfamily domain.
Nicastrin, a protein implicated in Alzheimer's disease, has a domain that is found in the aminopeptidase/transferrin receptor superfamily. In nicastrin, this domain might possess catalytic activity (as observed with aminopeptidases) or it could serve merely as a binding domain (with analogy to the transferrin receptors) for the beta-amyloid precursor protein.
Fagan
R
R
Inpharmatica, 60 Charlotte St, W1T 2NU, London, UK. r.fagan@inpharmatica.co.uk
Swindells
M
M
Overington
J
J
Weir
M
M
D000595:Amino Acid Sequence; D000626:Aminopeptidases / Q000378:metabolism*; D053829:Amyloid Precursor Protein Secretases; D006801:Humans; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D008565:Membrane Proteins / Q000378:metabolism*; D008969:Molecular Sequence Data; D053764:Presenilin-1; D053766:Presenilin-2; D011485:Protein Binding; D011990:Receptors, Transferrin / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid
D008562:Membrane Glycoproteins; D008565:Membrane Proteins; C508853:PSEN1 protein, human; C508861:PSEN2 protein, human; D053764:Presenilin-1; D053766:Presenilin-2; D011990:Receptors, Transferrin; C413604:nicastrin protein; D053829:Amyloid Precursor Protein Secretases; D000626:Aminopeptidases