title: Experimental study on facial nerve regeneration with or without geniculate ganglionectomy.
abstract: OBJECTIVE
  To investigate regeneration of the distal facial nerve following nerve grafting within the tympanic segment with geniculate ganglion preservation or dissection.
  
  
  METHODS
  Randomized controlled trial.
  
  
  METHODS
  Twenty-three adult New Zealand albino rabbits were used in this study.
  
  
  METHODS
  A 2-mm tympanic segment of the facial nerve was removed, and the greater auricular nerve was harvested for grafting in all animals. In group 1 (10 rabbits), the geniculate ganglion was preserved. In group 2 (13 rabbits), the geniculate ganglion was dissected. Mastoidal and extratemporal segments of the facial nerve were harvested 3 months postoperatively for histological examination by electron microscopy.
  
  
  RESULTS
  The number of myelinated axons in normal facial nerves was 1819.6 +/- 535.6. In group 1, the number of myelinated axons was 123.6 +/- 31.1, and, compared with normal facial nerves, the diameter of the regenerative axons was decreased and the sheath thickness in the regenerative fiber was diminished. In group 2, the number of myelinated axons was 515.1 +/- 103.1, while the myelin sheath thickness was proportionate to axon diameter. (Data are given as mean +/- SD.)
  
  
  CONCLUSIONS
  Geniculate ganglionectomy may improve motor axon regeneration.
authors: Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Shanghai Medical University, Shanghai 200031, People's Republic of China. daichf@online.sh.cn
authors: Z
authors: Z
authors: Wang
authors: C
authors: C
authors: Dai
authors: Y
authors: Y
authors: Zhang
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D005154:Facial Nerve / Q000502:physiology*; D005260:Female; D015171:Ganglionectomy; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D012038:Regeneration