Acanthamoeba keratitis associated with fungal keratitis.
OBJECTIVE
To report fungal infection complicating Acanthamoeba keratitis.


METHODS
Case report. A 45-year-old woman with contact lens-related bilateral Acanthamoeba keratitis developed corneal ulcer, corneal perforation, and mature cataract in the left eye, which was managed by penetrating keratoplasty, lensectomy, and vitrectomy.


RESULTS
Histopathologic examination of the keratoplasty specimen from the left eye revealed extensive lamellar stromal necrosis with the coexistence of both empty cysts and branching hyphae. Cultures from the keratoplasty specimen grew Scedosporium apiospermum.


CONCLUSIONS
Keratomycosis caused by S. apiospermum may complicate protracted Acanthamoeba keratitis.
Froumis
N A
NA
Jules Stein Eye Institute, Department of Ophthalmology UCLA School of Medicine, Los Angeles, California 90095-7000, USA.
Mondino
B J
BJ
Glasgow
B J
BJ
D000048:Acanthamoeba / Q000302:isolation & purification; D015823:Acanthamoeba Keratitis / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D000818:Animals; D002387:Cataract Extraction; D003262:Contact Lenses, Extended-Wear / Q000009:adverse effects; D003315:Cornea / Q000382:microbiology* / Q000469:parasitology* / Q000473:pathology / Q000601:surgery; D003320:Corneal Ulcer / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D015821:Eye Infections, Fungal / Q000209:etiology / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D015948:Keratoplasty, Penetrating; D008875:Middle Aged; D008271:Mycetoma / Q000209:etiology / Q000473:pathology / Q000601:surgery; D021681:Scedosporium / Q000302:isolation & purification*; D014821:Vitrectomy