Dynamic concentration of motors in microtubule arrays.
We present experimental and theoretical studies of the dynamics of molecular motors in microtubule arrays and asters. By solving a convection-diffusion equation we find that the density profile of motors in a two-dimensional aster is characterized by continuously varying exponents. Simulations are used to verify the assumptions of the continuum model. We observe the concentration profiles of kinesin moving in quasi-two-dimensional artificial asters by fluorescent microscopy and compare with our theoretical results.
Nédélec
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F
EMBL, Cell Biology, Heidelberg, Germany.
Surrey
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T
Maggs
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AC
D000255:Adenosine Triphosphate / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D004058:Diffusion; D016547:Kinesins / Q000737:chemistry* / Q000378:metabolism*; D008856:Microscopy, Fluorescence; D008870:Microtubules / Q000737:chemistry* / Q000378:metabolism*; D008954:Models, Biological; D008956:Models, Chemical
D000255:Adenosine Triphosphate; D016547:Kinesins