Synthesis and immunomodulatory activity of novel analogues of human beta-casein fragment [54-59].
Three novel analogues of human beta-casein fragment [54-59] have been synthesized and tested for their immunomodulatory activity. Interestingly, human beta-casein fragment [54-59] has been found to be increased nitric oxide release from neutrophils. The obtained analogues have shown less immunomodulatory activity than native hexapeptide.
Rysz
J
J
II Department of Internal Medicine, Military Academy of Medicine, 113 Zeromskiego, str. 90-549 Łódź.
Redliński
A
A
Mudyna
J
J
Luciak
M
M
Kamiński
Z J
ZJ
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000494:pharmacology; D000328:Adult; D002364:Caseins / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis*; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D002364:Caseins; D010446:Peptide Fragments; D009569:Nitric Oxide