title: Changes of transforming growth factor beta 1 in rat periodontal tissue during orthodontic tooth movement.
abstract: OBJECTIVE
  To investigate the distribution and change of transforming growth factor beta 1 (TGF-beta 1) in rat periodontal tissue and understand the role of TGF-beta 1 in orthodontic tooth movement.
  
  
  METHODS
  Force was applied on right maxillary first molars in rats, followed by the examination of the decalcified alveolodental connected tissue in different stages of tooth movement. An immunohistochemical staining technique (SP method) was used for this examination.
  
  
  RESULTS
  TGF-beta 1 exists in normal periodontal tissue. The expression of it in periodontium increases during orthodontic tooth movement. From 5 to 10 days after applying force, the expression at the tension site was significantly greater than that at the pressure site.
  
  
  CONCLUSIONS
  Changes in TGF-beta 1 levels play an important role in the remodeling of periodontal tissue during orthodontic tooth movement, and can powerfully promote bone formation.
authors: Department of Orthodontics, College of Stomatology, Norman Bethune University of Medical Science, No. 18-1 Ziqiang Street, Nanguan District, Changchun, 130041, P. R. China.
authors: L L
authors: LL
authors: Wang
authors: H
authors: H
authors: Zhu
authors: T
authors: T
authors: Liang
mesh_terms: D000539:Alveolar Process / Q000378:metabolism / Q000473:pathology; D000704:Analysis of Variance; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology; D016723:Bone Remodeling; D003739:Dental Cementum / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D008437:Maxilla / Q000378:metabolism / Q000473:pathology; D008963:Molar; D010006:Osteoblasts / Q000378:metabolism / Q000473:pathology; D010519:Periodontium / Q000378:metabolism* / Q000473:pathology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical; D014087:Tooth Movement Techniques; D016212:Transforming Growth Factor beta / Q000032:analysis / Q000378:metabolism*; D053773:Transforming Growth Factor beta1
chemical_list: C508962:Tgfb1 protein, rat; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1