A strong association between HLA-DR9 and gelatin allergy in the Japanese population.
The frequency of HLA class I and II phenotypes was determined among 23 patients with positive gelatin IgE, eight of whom developed anaphylaxis, 18 patients who did not have gelatin IgE but who experienced non-immediate reactions after exposure to gelatin. HLA-DR9, which is unique to Orientals, was present in 56.5% of the gelatin IgE positive patients, as compared to control population frequency of 24% (P < 0.002). In the non-immediate reaction group, who did not generate IgE, phenotype distribution resembled controls. HLA-DR9 positive individuals have a relative risk of 4.1 for developing gelatin allergy with positive IgE.
Kumagai
T
T
Pediatric Allergy and Infectious Diseases Society of Sapporo, Kumagai Pediatric Clinic, W-6, Momijidai, Atsubetsu-ku, 004-0013, Hokkaido, Sapporo, Japan.
Yamanaka
T
T
Wataya
Y
Y
Saito
A
A
Okui
T
T
Yano
S
S
Tsutsumi
H
H
Chiba
S
S
Wakisaka
A
A
D000707:Anaphylaxis / Q000209:etiology / Q000276:immunology; D016022:Case-Control Studies; D002675:Child, Preschool; D005260:Female; D005780:Gelatin / Q000009:adverse effects* / Q000276:immunology*; D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D007564:Japan; D008297:Male; D012307:Risk Factors; D014581:Urticaria / Q000209:etiology / Q000276:immunology; D014611:Vaccination / Q000009:adverse effects
D006684:HLA-DR Antigens; D059810:HLA-DR Serological Subtypes; C038988:HLA-DR9 antigen; D007073:Immunoglobulin E; D005780:Gelatin