Transport of organic anions by multidrug resistance-associated protein in the erythrocyte.
The active transport of oxidized glutathione and glutathione S-conjugates has been demonstrated for the first time in erythrocytes and this cell remained the main subject of research on the "glutathione S-conjugate pump" for years. Further studies identifled the "glutathione S-conjugate pump" as multidrug resistance-associated protein (MRP). Even though cells overexpressing MRP and isolated MRP provide useful information on MRP structure and function, the erythrocyte remains an interesting model cell for studies of MRP1 in its natural environment, including the substrate specificity and ATPase activity of the protein.
Rychlik
B
B
Department of Molecular Biophysics, University of Lódź, Poland.
Pułaski
L
L
Sokal
A
A
Soszyński
M
M
Bartosz
G
G
D018528:ATP-Binding Cassette Transporters / Q000097:blood*; D000838:Anions / Q000097:blood; D002352:Carrier Proteins / Q000097:blood; D018432:Drug Resistance, Multiple; D004912:Erythrocytes / Q000378:metabolism*; D005978:Glutathione / Q000031:analogs & derivatives / Q000097:blood; D019803:Glutathione Disulfide / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D017136:Ion Transport; D007700:Kinetics; D026901:Membrane Transport Proteins; D008954:Models, Biological; D027425:ATP-Binding Cassette, Sub-Family C Proteins
D018528:ATP-Binding Cassette Transporters; D000838:Anions; D002352:Carrier Proteins; D005978:Glutathione; D019803:Glutathione Disulfide; D026901:Membrane Transport Proteins; D027425:ATP-Binding Cassette, Sub-Family C Proteins; C086860:glutathione transporter; C030190:S-(2,4-dinitrophenyl)glutathione