Mania resulting from continuous positive airways pressure in a depressed man with sleep apnea syndrome.
The authors report the case of a 50-year-old man, with no previous history of bipolar illness, hospitalized with a very severe depression and who was resistant to a 7-weeks treatment of venlafaxine and trazodone (the respective daily doses were 300 and 50 mg which were stable during the last 4 weeks). A diagnosis of sleep apnea syndrome led to the use of the continuous positive airways pressure technique (CPAP). A few days after starting CPAP, he presented a mood switch, first hypomanic, then mixed. The authors discuss the contribution of the sleep apnea syndrome to the appearance and the maintenance of the depressive disorder.
Hilleret
H
H
Department of Psychiatry, University Hospital, Geneva, Switzerland.
Jeunet
E
E
Osiek
C
C
Mohr
S
S
Blois
R
R
Bertschy
G
G
D001714:Bipolar Disorder / Q000209:etiology*; D003866:Depressive Disorder / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011175:Positive-Pressure Respiration / Q000009:adverse effects*; D012891:Sleep Apnea Syndromes / Q000150:complications*