The association study of DRD2, ACE and AGT gene polymorphisms and metamphetamine dependence.
We investigated the association between metamphetamine dependence and TaqI A polymorphism of the dopamine receptor D2 gene (DRD2), I/D polymorphism in angiotensin-converting enzyme (ACE) and M235T polymorphism of the angiotensinogen gene (AGT) in 93 unrelated metamphetamine-dependent subjects and 131 controls. Our results did not prove any association of TaqI A polymorphism of the DRD2 gene, I/D polymorphism of ACE gene, and M235T polymorphism of AGT gene with the metamphetamine dependence in Caucasians of Czech origin. However, a significant difference in allele I frequency between male and female control groups for the I/D ACE polymorphism (p<0.03) was found.
Serý
O
O
Department of Comparative Animal Physiology and General Zoology, Masaryk University, Faculty of Science, Brno, Czech Republic. omarsery@sci.muni.cz
Vojtová
V
V
Zvolský
P
P
D000328:Adult; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D008694:Methamphetamine; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D012727:Sex Characteristics; D019966:Substance-Related Disorders / Q000235:genetics*
D017448:Receptors, Dopamine D2; D000808:Angiotensinogen; D008694:Methamphetamine; D015252:Deoxyribonucleases, Type II Site-Specific; C027046:TCGA-specific type II deoxyribonucleases; D007703:Peptidyl-Dipeptidase A