Rank-based tests for dose finding in nonmonotonic dose-response settings.
Lim and Wolfe (1997, Biometrics 53, 410-418) proposed rank-based multiple test procedures for identifying the dose levels that are more effective than the zero-dose control in randomized complete block designs when it can be assumed that the efficacy of the increasing dose levels is monotonically increasing up to a point, followed by a monotonic decrease. Modifications of the Lim-Wolfe tests are suggested that provide more practical and powerful alternatives. Two numerical examples are illustrated and the results of a Monte Carlo power study are presented.
Chen
Y I
YI
Institute of Statistics, National Central University Chung-Li, Taiwan. ychen@stat.ncu.edu.tw
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001699:Biometry; D003913:Dextroamphetamine / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D015233:Models, Statistical; D009010:Monte Carlo Method; D011897:Random Allocation; D051381:Rats
D003913:Dextroamphetamine