title: Fluid dynamics in airway bifurcations: I. Primary flows.
abstract: The subject of fluid dynamics within human airways is of great importance for the risk assessment of air pollutants (inhalation toxicology) and the targeted delivery of inhaled pharmacologic drugs (aerosol therapy). As cited herein, experimental investigations of flow patterns have been performed on airway models and casts by a number of investigators. We have simulated flow patterns in human lung bifurcations and compared the results with the experimental data of Schreck (1972). The theoretical analyses were performed using a third-party software package, FIDAP, on the Cray T90 supercomputer. This effort is part of a systematic investigation where the effects of inlet conditions, Reynolds numbers, and dimensions and orientations of airways were addressed. This article focuses on primary flows using convective motion and isovelocity contour formats to describe fluid dynamics; subsequent articles in this issue consider secondary currents (Part II) and localized conditions (Part III). The agreement between calculated and measured results, for laminar flows with either parabolic or blunt inlet conditions to the bifurcations, was very good. To our knowledge, this work is the first to present such detailed comparisons of theoretical and experimental flow patterns in airway bifurcations. The agreement suggests that the methodologies can be employed to study factors affecting airflow patterns and particle behavior in human lungs.
authors: Mail Drop 74, National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, NC 27711, USA. martonen.ted@epa.gov
authors: T B
authors: TB
authors: Martonen
authors: X
authors: X
authors: Guan
authors: R M
authors: RM
authors: Schreck
mesh_terms: D001980:Bronchi / Q000502:physiology*; D006801:Humans; D008953:Models, Anatomic; D008962:Models, Theoretical; D012123:Pulmonary Ventilation; D014132:Trachea / Q000502:physiology*