Antinociceptive effect of Elaeagnus angustifolia fruit seeds in mice.
The antinociceptive effect of different Elaeagnus angustifolia fruit seed extractives was studied in mice using hot-plate and writhing tests. Following intraperitoneal injection, the decoction (EaDE), the ethanol extract (EaEE), the aqueous and n-butanol fractions (EaAF, and EaBF, respectively) of a polyphenolic fraction, and two flavonoid-enriched fractions of EaBF (EaBCF1 and EaBCF2) showed significant antinociceptive activity in both tests, markedly and dose-dependently increasing the pain threshold.
Ramezani
M
M
Faculty of Pharmacy, Mashhad University of Medical Sciences, P.O. Box 91775-1365, I.R., Mashhad, Iran. mapharm@sinasoft.net
Hosseinzadeh
H
H
Daneshmand
N
N
D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology; D010946:Plants, Medicinal; D019685:Rosales; D012639:Seeds
D000700:Analgesics; D010936:Plant Extracts; D019342:Acetic Acid