title: Possible modes of action of the artemisinin-type compounds.
abstract: Artemisinin-type compounds are used for the treatment of uncomplicated and severe forms of malaria. They reduce parasitaemia more rapidly than any other antimalarial compound known, and are effective against multidrug-resistant parasites. However, uncertainties remain as to how they act on the parasite and cause toxicity. In this review, we summarize current ideas.
authors: UNDP/World Bank/WHO Special Programme on Research and Training in Tropical Diseases, CDS Cluster, 20, avenue Appia, CH-1211, Geneva, Switzerland. olliarop@who.ch
authors: P L
authors: PL
authors: Olliaro
authors: R K
authors: RK
authors: Haynes
authors: B
authors: B
authors: Meunier
authors: Y
authors: Y
authors: Yuthavong
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D037621:Artemisinins; D006801:Humans; D016778:Malaria, Falciparum / Q000188:drug therapy / Q000469:parasitology; D010963:Plasmodium falciparum / Q000187:drug effects*; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin