DNA repair: spot(light)s on chromatin.
Chromatin modifications regulate many nuclear processes. Recent studies on the phosphorylation of a histone 2A variant have revealed that this chromatin modification is a general and evolutionarily conserved cellular response to DNA double-strand breaks.
Modesti
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Department of Cell Biology and Genetics, Erasmus University Rotterdam, PO Box 1738, 3000 DR, Rotterdam, The Netherlands.
Kanaar
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D000818:Animals; D002843:Chromatin / Q000378:metabolism*; D004249:DNA Damage; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D004260:DNA Repair; D006657:Histones / Q000378:metabolism*; D006801:Humans; D008540:Meiosis / Q000502:physiology; D009687:Nuclear Proteins / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism; D011995:Recombination, Genetic; D045567:VDJ Recombinases
D002843:Chromatin; D006657:Histones; D009687:Nuclear Proteins; D019869:Phosphatidylinositol 3-Kinases; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases