title: Juxtaposition of CNR protocadherins and reelin expression in the developing spinal cord.
abstract: The CNR (cadherin-related neuronal receptors) family of protocadherins is of great interest because of their potential roles as molecular tags in the formation of specific synaptic connections, and as receptors for reelin, during neuronal migration, and cell body positioning. In order to know more about potential functions of CNRs we have mapped their expression during mouse nervous system development and compared their expression with that of reelin and its intracellular effector Dab1 in several tissues. In spinal cord, CNRs and Dab1 are expressed in motoneurons, while reelin is located in adjacent cells. In the hindbrain, there is a differential expression of CNRs and Dab1 in various motor nuclei. In the retina and olfactory system, we observe CNR and reelin expression but not that of Dab1. These results provide new insights into the potential functions of CNRs and their possible integration in the reelin pathway during development.
authors: INSERM U382, Developmental Biology Institute of Marseille (IBDM), CNRS/INSERM/Université de la Méditerranée/AP de Marseille, Campus de Luminy, Case 907, Marseille Cedex 09, 13288, France. carroll@ibdm.univ-mrs.fr
authors: P
authors: P
authors: Carroll
authors: O
authors: O
authors: Gayet
authors: C
authors: C
authors: Feuillet
authors: S
authors: S
authors: Kallenbach
authors: B
authors: B
authors: de Bovis
authors: K
authors: K
authors: Dudley
authors: S
authors: S
authors: Alonso
mesh_terms: D000818:Animals; D015820:Cadherins / Q000235:genetics*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics*; D018076:DNA, Complementary; D016326:Extracellular Matrix Proteins / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental; D017403:In Situ Hybridization; D051379:Mice; D009046:Motor Neurons / Q000737:chemistry / Q000502:physiology; D009419:Nerve Tissue Proteins; D009833:Olfactory Pathways / Q000166:cytology / Q000196:embryology / Q000502:physiology; D011498:Protein Precursors / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D000091042:Reelin Protein; D012249:Rhombencephalon / Q000166:cytology / Q000196:embryology / Q000502:physiology; D012697:Serine Endopeptidases; D015398:Signal Transduction / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology* / Q000502:physiology*; D014795:Visual Pathways / Q000166:cytology / Q000196:embryology / Q000502:physiology
chemical_list: D015820:Cadherins; D015816:Cell Adhesion Molecules, Neuronal; D018076:DNA, Complementary; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D011498:Protein Precursors; D012333:RNA, Messenger; D000091042:Reelin Protein; C000717129:Reln protein, rat; C000717128:Reln protein, mouse; D012697:Serine Endopeptidases