title: Lack of effect of the abnormal fatty acid metabolism in NC/Nga mice on their atopic dermatitis.
abstract: Although clinical evidence has suggested that dysregulated fatty acid metabolism is associated with atopic disorders, the molecular basis for such a correlation remains to be demonstrated. In the present study, we analyzed the fatty acid composition in peripheral blood cells of NC/Nga mice, a model for atopic dermatitis (AD). We found that arachidonic acid significantly accumulated in mice with the AD manifestation. In addition, the leucotriene B4-releasing ability upon calcium ionophore A23187 stimulation was potentiated in blood cells. An arachidonic acid accumulation was not apparent in the non-atopic BALB/c strain, but was still observed in healthy NC/Nga mice fed under specific pathogen-free conditions. These results indicate that a disturbed fatty acid metabolism in NC/Nga mice was not a trigger factor for their dermatitis development.
authors: Department of Molecular Biotechnology, Graduate School of Advanced Sciences of Matter, Hiroshima University, Higashi-Hiroshima, Japan. skawa@hiroshima-u.ac.jp
authors: S
authors: S
authors: Kawamoto
authors: M
authors: M
authors: Kita
authors: M
authors: M
authors: Hamada
authors: T
authors: T
authors: Aki
authors: S
authors: S
authors: Shigeta
authors: O
authors: O
authors: Suzuki
authors: K
authors: K
authors: Ono
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000097:blood; D001773:Blood Cells / Q000187:drug effects / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D003876:Dermatitis, Atopic / Q000097:blood* / Q000235:genetics; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000097:blood* / Q000737:chemistry; D006801:Humans; D066298:In Vitro Techniques; D007476:Ionophores / Q000494:pharmacology; D007975:Leukotriene B4 / Q000097:blood; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008817:Mice, Mutant Strains; D017962:alpha-Linolenic Acid / Q000097:blood
chemical_list: D005227:Fatty Acids; D007476:Ionophores; D017962:alpha-Linolenic Acid; D007975:Leukotriene B4; D016718:Arachidonic Acid; D000001:Calcimycin