[The role of the intestine in the pathogenesis of the multi-organ dysfunction syndrome in diffuse peritonitis].
Extraction of oxygen (O2), ultrastructural organization of intestinal macrophages and translocation of microorganisms were studied on 50 male rats of Wistar line in 2, 6, 12, 24 and 48 hours after the stimulation operation performance (control group) and modelling of an acute purulent peritonitis (APP)--basic group. Increase of common and lowering of intestinal extraction of O2 in early terms of the APP occurrence, accompanied by intensive reproduction of microorganisms and change of intestinal biocenosis, was noted. These infringements correlated with translocation of microorganisms through mesenteric lymphatic nodes--ductus toracicus--systemic blood flow (basic way) in term up to 24 hours and through portal vein--hepar--systemic blood flow (additional way)--up to 48 hours after the APP beginning.
Krivoruchko
I A
IA
Boĭko
V V
VV
Ivanova
Iu V
IuV
Gusak
I V
IV
Andreeshchev
S A
SA
D000818:Animals; D007413:Intestinal Mucosa / Q000378:metabolism*; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D008297:Male; D009102:Multiple Organ Failure / Q000150:complications*; D010538:Peritonitis / Q000150:complications* / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar