Lignans as anti-tumor-promoter from the seeds of Hernandia ovigera.
Seven lignans (2-8) isolated from the seeds of Hernandia ovigera L. (Hernandiaceae) were tested for their inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. Using a primary screening test, all the lignans showed inhibitory activity with IC50 470-590 mol ratio/32 pmol TPA. The data demonstrated that these lignans might be valuable anti-tumor-promoters.
Ito
C
C
Itoigawa
M
M
Ogata
M
M
Mou
X Y
XY
Tokuda
H
H
Nishino
H
H
Furukawa
H
H
D016588:Anticarcinogenic Agents / Q000302:isolation & purification / Q000627:therapeutic use*; D000956:Antigens, Viral / Q000187:drug effects*; D006801:Humans; D017705:Lignans / Q000302:isolation & purification / Q000627:therapeutic use*; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D012639:Seeds / Q000737:chemistry; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; C033305:Epstein-Barr virus early antigen; D017705:Lignans; D013755:Tetradecanoylphorbol Acetate