December 2000: 6 month old boy with 2 week history of progressive lethargy.
This 6-month-old Caucasian boy presented with a 10-day history of lethargy, obtundation, inability to hold his head up and mild torticollis. MRI and CT scans showed a large solid and cystic mass involving the right temporal, parietal and occipital lobes, pineal, superior pons, mesencephalon and posterior right thalamus. He underwent craniotomy initially for a partial tumor resection with an intraoperative diagnosis of desmoplastic astrocytoma. With immunohistochemistry and special stains the diagnosis of desmoplastic infantile ganglioglioma (DIG) was made. A near total resection was performed a week after initial resection.The patient then was treated with chemotherapy. Two months later an MRI showed tumor growth. Following additional aggressive chemotherapy, an MRI at 5 months post-resection indicated further tumor progression. This case illustrates that some DIGs may behave more aggressively than typical WHO grade I lesions.
Fan
X
X
Department of Pathology, Vanderbilt University Medical Center, Nashville, TN, USA.
Larson
T C
TC
Jennings
M T
MT
Tulipan
N B
NB
Toms
S A
SA
Johnson
M D
MD
D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D018303:Ganglioglioma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009457:Neuroglia / Q000473:pathology; D012894:Sleep Stages; D013714:Tennessee; D044465:White People
D005904:Glial Fibrillary Acidic Protein