An improved method for the palladium-catalyzed amination of aryl iodides.
Aryl iodides are coupled with amines to give the corresponding arylamines in high yield in the presence of palladium, a suitable ligand, and NaOt-Bu. Functionalized aryl iodides give good yields of the corresponding arylamines when Cs(2)CO(3) is substituted as the base.
Ali
M H
MH
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Buchwald
S L
SL
D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry; D008024:Ligands; D010165:Palladium
D000588:Amines; D006841:Hydrocarbons, Aromatic; D007454:Iodides; D008024:Ligands; D010165:Palladium