Inhibition of vascular endothelial growth factor by octreotide in colorectal cancer patients.
Vascular endothelial growth factor (VEGF) seems to be essential for angiogenesis and for the growth of colorectal cancer; thus its inhibition can arrest tumor growth and decrease metastatic potential. Octreotide has been shown to inhibit growth of colorectal tumors in vitro and in vivo. Part of the antiproliferative activity of octreotide could be related to its antiangiogenic properties. Effects of octreotide on VEGF expression were evaluated in 35 patients with operable colorectal cancer receiving octreotide for 2 weeks before surgery. Tissue VEGF expression and serum VEGF concentrations were determined before and after treatment with octreotide. There was a statistically significant reduction in the tissue VEGF expression both considering the percentage of VEGF positive cells (P = 0.006) and the intensity of VEGF staining (P = 0.003). A similar significant reduction was observed in serum values of VEGF (P = 0.03). The present study indicates that octreotide inhibits expression of VEGF in colorectal cancer patients, and, furthermore, that serum VEGF expression correlates with tissue VEGF, representing a safe method to monitor the activity of antiangiogenic agents.
Cascinu
S
S
Sezione di Oncologia Sperimentale, Azienda Ospedaliera Ospedale S. Salvatore, 61100 Pesaro, Italy. cascinu@yahoo.com
Del Ferro
E
E
Ligi
M
M
Staccioli
M P
MP
Giordani
P
P
Catalano
V
V
Agostinelli
R
R
Muretto
P
P
Catalano
G
G
D000368:Aged; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008222:Lymphokines / Q000037:antagonists & inhibitors*; D008297:Male; D008875:Middle Aged; D015282:Octreotide / Q000494:pharmacology*; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D015282:Octreotide