Application of magnetic resonance imaging to angiogenesis in breast cancer.
Magnetic resonance imaging (MRI) techniques enable vascular function to be mapped with high spatial resolution. Current methods for imaging in breast cancer are described, and a review of recent studies that compared dynamic contrast-enhanced MRI with histopathological indicators of tumour vascular status is provided. These studies show correlation between in vivo dynamic contrast measurements and in vitro histopathology. Dynamic contrast-enhanced MRI is also being applied to assessment of the response of breast tumours to treatment.
Leach
M O
MO
CRC Clinical Magnetic Resonance Research Group, The Institute of Cancer Research and The Royal Marsden NHS Trust, Sutton, Surrey, UK. Martin@icr.ac.uk
D000818:Animals; D018952:Antigens, CD34 / Q000032:analysis; D001943:Breast Neoplasms / Q000098:blood supply* / Q000175:diagnosis; D003287:Contrast Media; D016228:Endothelial Growth Factors / Q000032:analysis; D005260:Female; D006801:Humans; D008222:Lymphokines / Q000032:analysis; D008279:Magnetic Resonance Imaging; D008327:Mammography; D051379:Mice; D008819:Mice, Nude; D009389:Neovascularization, Pathologic / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012106:Research; D014183:Transplantation, Heterologous; D014463:Ultrasonography; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D018952:Antigens, CD34; D003287:Contrast Media; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors