Comparative study of diclofenac sodium and paracetamol for treatment of pain after adenotonsillectomy in children.
OBJECTIVE
To compare the analgesic efficacy of diclofenac sodium and paracetamol on post adenotonsillectomy postoperative pain and oral intake.


METHODS
Between January 1999 and July 2000, 80 children aged 3-14 years, underwent tonsillectomy and adenoidectomy for either recurrent tonsillitis or adenotonsillar hypertrophy in Prince Zeid Ben Al-Hussein Hospital and Prince Rashid Ben Al-Hussein Hospital. Forty-one children received diclofenac sodium suppositories (1-3mg/kg) postoperatively, whereas 39 children received only paracetamol syrup (10-15 mg/kg) in 4 divided doses. All children were observed for postoperative pain, oral intake, vomiting, temperature and complications.


RESULTS
Children who received diclofenac sodium had significantly less pain, less elevation of temperature, more oral intake, and started drinking significantly sooner than the paracetamol group. Two children in the diclofenac group experienced nausea and vomiting compared to 12 children in the paracetamol group in the first day. The time to first solid intake was significantly earlier in the diclofenac sodium group (p < 0.0001). With regard to complications, one patient in each group developed secondary hemorrhage, one child developed otitis media in the 2nd group. Each group had one readmission, and 2 children from the paracetamol group had an emergency department visit for pain and dehydration.


CONCLUSIONS
Diclofenac sodium has a significant effect on decreasing the pain associated with swallowing postoperatively and on the general condition of the patient. Improved oral intake resulted in a lower incidence of nausea and vomiting and allowed safer and earlier hospital discharge.
Tawalbeh
M I
MI
Prince Rashid Ben Al-Hassan Hospital, Al-Husn, Jordan. mohtawal@hotmail.com
Nawasreh
O O
OO
Husban
A M
AM
D000082:Acetaminophen / Q000627:therapeutic use*; D000233:Adenoidectomy; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004008:Diclofenac / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D010149:Postoperative Pain / Q000188:drug therapy*; D014068:Tonsillectomy
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D000082:Acetaminophen