Long-term survival of a patient with giant cell glioblastoma. Case report.
The authors report on a patient who had undergone resection of a left-sided temporal giant cell glioblastoma at the age of 69 years and who survived for more than 17 years. This man had not undergone postoperative radiotherapy or adjuvant chemotherapy. He died at the age of 86 years without clinical evidence of tumor recurrence. Histologically, the lesion was characterized by highly pleomorphic tumor cells (including bizarre multinucleated giant cells) with high mitotic activity, large necroses, and prominent mononuclear infiltration. A point mutation in the TP53 tumor suppressor gene (c.524G>A; R175H) and no epidermal growth factor receptor gene amplification were revealed on molecular genetic analysis. No diagnostic chromosomal imbalances were identified on comparative genomic hybridization, although the average ratio profile for chromosome 10 indicated loss of 10p15 in a subpopulation of tumor cells. This patient is exceptional because tumor resection, probably in conjunction with a marked antitumor immune response, apparently resulted in eradication of the lesion.
Sabel
M
M
Department of Neurosurgery, Heinrich-Heine-University, Düsseldorf, Germany. sabel@uni-duesseldorf.de
Reifenberger
J
J
Weber
R G
RG
Reifenberger
G
G
Schmitt
H P
HP
D000368:Aged; D001483:Base Sequence / Q000235:genetics; D001932:Brain Neoplasms / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D016158:Genes, p53 / Q000235:genetics; D005909:Glioblastoma / Q000235:genetics / Q000473:pathology / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008967:Molecular Biology; D009693:Nucleic Acid Hybridization; D017354:Point Mutation / Q000235:genetics; D013702:Temporal Lobe; D013997:Time Factors