Prevention and treatment of lethal murine endotoxemia by the novel immunomodulatory agent MFP-14.
Multifunctional protein 14 (MFP-14) is a ubiquitous protein that inhibits the production of tumor necrosis factor alpha (TNF-alpha) and gamma interferon (IFN-gamma), which are involved in the pathogenesis of sepsis. Here, lipopolysaccharide (LPS)-induced lethality in mice was markedly reduced by MFP-14. The treatment also lowered LPS-induced levels of TNF-alpha and IFN-gamma in the blood.
Nicoletti
F
F
Department of Clinical Medicine, Prevention and Biotechnological Health, University of Milan Bicocca, Italy. ferdinic@ctonline.it
Di Marco
R
R
Sacerdote
P
P
Meroni
P
P
Mangano
K
K
Edwards
C
C
Bartorelli
A
A
Bendtzen
K
K
Panerai
A
A
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D019446:Endotoxemia / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D006360:Heat-Shock Proteins / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000378:metabolism; D008070:Lipopolysaccharides; D051379:Mice; D008807:Mice, Inbred BALB C; D011506:Proteins; D012260:Ribonucleases; D016896:Treatment Outcome; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000276:Adjuvants, Immunologic; D006360:Heat-Shock Proteins; D008070:Lipopolysaccharides; C490787:MFP14 protein, mouse; D011506:Proteins; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma; D012260:Ribonucleases