Activation of the dopaminergic system of medial prefrontal cortex of gerbils during formation of relevant associations for the avoidance strategy in the shuttle-box.
1. A detailed analysis of behavior is a prerequisite for identification of components of information processing during learning. 2. Components of shuttle-box learning like the signal detection and signal evaluation can be differentiated using behavioral events such as the attention response and the orienting response. 3. Chiefly during evaluation of signal meaning in the acquisition phase of the avoidance strategy the extracellular DA is increased in mPFC. 4. The kinetics of prefrontal dopaminergic activation from trial to trial depends on the stage of avoidance learning. 5. The increase of DA in mPFC can be an indicator for the involvement of working memory principles in signal evaluation stages of conditioning.
Stark
H
H
Department of Auditory Plasticity and Speech, Leibniz Institute for Neurobiology, Magdeburg, Germany. stark@ifn-magdeburg.de
Bischof
A
A
Wagner
T
T
Scheich
H
H
D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology*; D001288:Attention / Q000502:physiology; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004298:Dopamine / Q000378:metabolism*; D004867:Equipment Design; D005849:Gerbillinae; D017551:Microdialysis; D015999:Multivariate Analysis; D009627:Nomifensine / Q000494:pharmacology; D009949:Orientation / Q000502:physiology; D017397:Prefrontal Cortex / Q000187:drug effects / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D013779:Tetrodotoxin / Q000494:pharmacology
D009627:Nomifensine; D013779:Tetrodotoxin; D004298:Dopamine