Hemoglobin variants and determination of glycated hemoglobin (HbA1c).
Measurement of glycated hemoglobin in diabetic patients is an established procedure for evaluating long-term control of diabetes. The Diabetes Control and Complications Trial (DCCT), as well as the United Kingdom Prospective Diabetes Study (UKPDS), confirmed the direct relationship between the degree of glycemic control as estimated by glycohemoglobin (GHb) determinations and the development and progression of long-term complications in diabetic patients. Samples with known interferences of HbA(1c) determination as hemoglobinopathies are specifically excluded from certification testing and there are no guidelines or requirements for comparability of samples containing hemoglobin (Hb) variants. This paper reviews the interference of Hb variants on determination methods of glycated hemoglobin as they result in false HbA(1c) results.
Schnedl
W J
WJ
Department of Internal Medicine, Karl-Franzens University School of Medicine, Auenbruggerplatz 15, A-8036 Graz, Austria. wolfgang.schnedl@kfunigraz.ac.at
Liebminger
A
A
Roller
R E
RE
Lipp
R W
RW
Krejs
G J
GJ
D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism*; D014644:Genetic Variation; D006442:Glycated Hemoglobin / Q000032:analysis*; D006454:Hemoglobins / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000032:analysis* / Q000235:genetics; D006801:Humans
D015415:Biomarkers; D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006454:Hemoglobins; D006455:Hemoglobins, Abnormal