The neutrophil: function and regulation in innate and humoral immunity.
The neutrophil is a critical effector cell in humoral and innate immunity and plays vital roles in phagocytosis and bacterial killing. Discussed here are the neutrophil components necessary for these processes and the diseases in which these components are either lacking or dysfunctional, illustrating that normal neutrophil function is vital for health.
Burg
N D
ND
Department of Medicine, New York University School of Medicine, New York, New York 10016, USA. natburg@yahoo.com
Pillinger
M H
MH
D000818:Animals; D002448:Cell Adhesion; D003594:Cytoplasmic Granules / Q000502:physiology; D006801:Humans; D007109:Immunity; D007249:Inflammation / Q000276:immunology; D020928:Mitogen-Activated Protein Kinases / Q000502:physiology; D019255:NADPH Oxidases / Q000502:physiology; D009504:Neutrophils / Q000502:physiology*; D010084:Oxidation-Reduction; D010587:Phagocytosis; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology
D019255:NADPH Oxidases; D019869:Phosphatidylinositol 3-Kinases; D020928:Mitogen-Activated Protein Kinases