title: Helicobacter pylori-associated gastritis and the ascorbic acid concentration in gastric juice.
abstract: Patients infected with Helicobacter pylori have abnormally low ascorbic acid concentration in gastric juice. Low vitamin C intake and Helicobacter pylori infection have been related to an increased risk of gastric carcinoma. This report examines the association between ascorbic acid and Helicobacter pylori in patients referred for upper gastrointestinal endoscopy. Elevated gastric pH and the damage to the gastric surface epithelium were inversely associated with the ascorbic acid concentration in gastric juice. We postulate that these two factors mediate the ascorbic acid-decreasing effect of Helicobacter pylori. Patients with nonpremalignant conditions (normal gastric histology, diffuse antral gastritis, or duodenal ulcer) had lower gastric pH, less damage to the gastric epithelium, and higher levels of ascorbic acid in gastric juice than patients with atrophic gastritis, intestinal metaplasia, or dysplasia.
authors: Clinical Research Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
authors: J C
authors: JC
authors: Rood
authors: B
authors: B
authors: Ruiz
authors: E T
authors: ET
authors: Fontham
authors: G T
authors: GT
authors: Malcom
authors: F M
authors: FM
authors: Hunter
authors: M
authors: M
authors: Sobhan
authors: W D
authors: WD
authors: Johnson
authors: P
authors: P
authors: Correa
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001205:Ascorbic Acid / Q000378:metabolism*; D016099:Endoscopy, Gastrointestinal; D005260:Female; D005750:Gastric Juice / Q000737:chemistry*; D005756:Gastritis / Q000378:metabolism* / Q000382:microbiology / Q000473:pathology; D016481:Helicobacter Infections / Q000378:metabolism* / Q000473:pathology; D016480:Helicobacter pylori; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000382:microbiology / Q000473:pathology
chemical_list: D001205:Ascorbic Acid