Properties and applications of the (2-nitrofluoren-9-yl)methoxycarbonyl group.
This paper presents a new protecting group, the (2-nitrofluoren-9-yl)methoxycarbonyl group. Investigations on the properties of this new modification of the Fmoc-system, such as the solvent-dependent photochemical cleavage, and enhanced lability towards bases, are described, as well as UV-kinetic measurements of the cleavage reaction. In addition, the incorporation of the (2-nitrofluoren-9-yl)methoxycarbonyl group into two peptides, and a sequence-dependent photochemical cleavage reaction are reported.
Henkel
B
B
Morphochem AG, München, Germany.
Bayer
E
E
D000596:Amino Acids / Q000737:chemistry*; D002244:Carbon / Q000737:chemistry*; D005449:Fluorenes / Q000737:chemistry*; D007700:Kinetics; D008027:Light; D008956:Models, Chemical; D010452:Peptide Biosynthesis; D010455:Peptides / Q000737:chemistry; D013997:Time Factors; D014466:Ultraviolet Rays
D000596:Amino Acids; D005449:Fluorenes; C016456:N(alpha)-fluorenylmethyloxycarbonylamino acids; D010455:Peptides; C047878:2-nitro-9-fluorenone; D002244:Carbon