DC-SIGN, a dentritic cell-specific HIV-1 receptor present in placenta that infects T cells in trans-a review.
Dendritic cells (DC) capture micro-organisms that enter peripheral mucosal tissues and then migrate to secondary lymphoid organs, where they present in antigenic form to resting T cells and thus initiate adaptive immune responses. Here we describe the properties of a DC-specific C-type lectin, DC-SIGN, that is highly expressed on DC present in mucosal tissues and binds to the HIV-1 envelope glycoprotein gp120. DC-SIGN does not function as a receptor for viral entry into DC, but instead promotes efficient infection in trans of cells that express CD4 and chemokine receptors. The interaction of DC-SIGN with HIV gp120 may be an important target for therapeutic intervention and vaccine development.
Geijtenbeek
T B
TB
Department of Tumor Immunology, University Medical Center St Radboud, Philips van Leydenlaan 25, Nijmegen, 6525 EX, The Netherlands.
van Vliet
S J
SJ
van Duijnhoven
G C
GC
Figdor
C G
CG
van Kooyk
Y
Y
D015815:Cell Adhesion Molecules; D005260:Female; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015497:HIV-1 / Q000378:metabolism*; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D037181:Lectins, C-Type; D008198:Lymph Nodes / Q000378:metabolism / Q000821:virology; D009092:Mucous Membrane / Q000378:metabolism / Q000821:virology; D010920:Placenta / Q000378:metabolism* / Q000821:virology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015728:Receptors, HIV / Q000378:metabolism*; D013601:T-Lymphocytes / Q000378:metabolism* / Q000821:virology; D014764:Viral Proteins / Q000378:metabolism*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D015699:HIV Envelope Protein gp120; D037102:Lectins; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D015728:Receptors, HIV; D014764:Viral Proteins; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin