Lepromatous vasculitis successfully treated by plasma exchange (PE).
Vascular involvement is presently considered a "common pathway" in a number of diseases that is mediated by circulating immune complexes (CIC). CIC are found in the circulation when the disease is active and in single patients their level may parallel disease activity. Lepromatous leprosis is characterized by the presence of CIC and deposits of immunoglobulins and complement in vascular lesions of the different organs and an Arthus-like mechanism is considered as the basis for the clinical picture. The same mechanism is considered to play an essential pathophysiologic role in Lucio's phenomenon, which is characterized by lymphohistiocytic vascular infiltrates with or without thrombosis and secondary cutaneous infarction. Lepromatous vascular involvement is mediated by CIC whose antigen composition is known, the same as it is with HCV mediated cryoglobulinemia, HBV positive panarteritis nodosa, rheumatoid vasculitis, or Wagner's granulomatosis, which are usually treated by PE [1-3]. PE has been employed for lepromatous vasculitis since 1979 [4] and other cases have been successfully treated afterwards [5,6]. We report on another patient successfully treated by plasma exchange.
Ruzzenenti
M R
MR
Immunohematology Service, S. Martino University Hospital, Genova, Italy.
Bruni
R
R
Florio
G
G
De Luigi
M C
MC
Lercari
G
G
Barabino
G F
GF
Nunzi
E
E
Valbonesi
M
M
D006801:Humans; D015440:Leprosy, Lepromatous / Q000150:complications* / Q000276:immunology / Q000628:therapy*; D008875:Middle Aged; D010951:Plasma Exchange; D014657:Vasculitis / Q000209:etiology* / Q000276:immunology / Q000628:therapy*