Linkage studies of SOX13, the ICA12 autoantigen gene, in families with type 1 diabetes.
SOX13 is a member of the SOX family of transcription factors that encodes the type 1 diabetes autoantigen, ICA12. The SOX13 gene maps at chromosome 1q31.3-32.1 near a region containing a susceptibility locus for type 1 diabetes. SOX13 was assessed as a candidate susceptibility gene. Analysis of the SOX13 gene identified a number of single nucleotide polymorphisms and a polymorphic CA dinucleotide repeat. Linkage and association studies indicate that SOX13 is unlikely to make a substantial contribution to type 1 diabetes susceptibility.
Argentaro
A
A
Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria 3010, Australia.
Wapelhorst
B
B
Concannon
P
P
Harley
V R
VR
D001324:Autoantigens / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D004247:DNA / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D005190:Family; D005787:Gene Frequency; D005838:Genotype; D006609:High Mobility Group Proteins / Q000235:genetics*; D006801:Humans; D020641:Polymorphism, Single Nucleotide; D055755:SOXD Transcription Factors
D001324:Autoantigens; D006609:High Mobility Group Proteins; C491720:SOX13 protein, human; D055755:SOXD Transcription Factors; D004247:DNA