Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages.
Ito
K
K
Thoracic Medicine, National Heart & Lung Institute, Imperial College School of Medicine, Dovehouse Street, London SW3 6LY, UK.
Lim
S
S
Caramori
G
G
Chung
K F
KF
Barnes
P J
PJ
Adcock
I M
IM
D000123:Acetyltransferases / Q000378:metabolism; D001706:Biopsy; D001980:Bronchi / Q000201:enzymology / Q000473:pathology; D018893:Bronchoalveolar Lavage; D016207:Cytokines / Q000096:biosynthesis* / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D015870:Gene Expression; D005938:Glucocorticoids / Q000494:pharmacology; D051548:Histone Acetyltransferases; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases / Q000096:biosynthesis / Q000378:metabolism*; D006801:Humans; D016676:Macrophages, Alveolar / Q000187:drug effects*; D018384:Oxidative Stress / Q000502:physiology; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D012907:Smoking / Q000235:genetics / Q000378:metabolism* / Q000473:pathology
D016207:Cytokines; D005938:Glucocorticoids; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D003907:Dexamethasone; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; D056464:Histone Deacetylase 2; D006655:Histone Deacetylases