New t(11;12)(q12;q11) characterized by RxFISH in a patient with T-cell large granular lymphocyte leukemia.
Chromosomal abnormalities in patients with large granular lymphocyte leukemia (LGLL) are rare. Herein we present a novel cytogenetic abnormality t(11;12)(q12;q11) in a patient with LGLL identified by cross-species color banding (RxFISH). The application of RxFISH allowed the rapid and easy identification of a chromosome rearrangement that was not recognized by conventional cytogenetics. Therefore, RxFISH is a suitable complement to, but not a replacement for, conventional cytogenetics.
Salido
M
M
Laboratori de Citologia Hematològica/Laboratori de Referència de Catalunya, Unitat d'Hematologia 1973, Hospital del Mar, IMAS, IMIM, Barcelona, Spain. e0037@imas.imim.es
Solé
F
F
Espinet
B
B
Zamora
L
L
Woessner
S
S
Florensa
L
L
D000368:Aged; D000369:Aged, 80 and over; D002880:Chromosomes, Human, Pair 11; D002881:Chromosomes, Human, Pair 12; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods*; D007621:Karyotyping; D015458:Leukemia, T-Cell / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic