title: The first synthesis of enantiopure alpha-amino ketimines and amino aziridines.
abstract: Chiral 1-aminoalkyl chloromethyl ketimines 2 are synthesized in enantiomerically pure form starting from 1-aminoalkyl chloromethyl ketones 1 and different amines. Reduction of amino ketimines 2 and subsequent spontaneous cyclization affords aminoalkyl aziridines 3 with high diastereoisomeric excess and without detectable racemization.
authors: Departamento de Química Física y Analítica, Facultad de Química, Universidad de Oviedo, Julián Clavería 8, 33071 Oviedo, Spain. jmcg@sauron.quimica.uniovi.es
authors: J M
authors: JM
authors: Concellón
authors: P L
authors: PL
authors: Bernad
authors: E
authors: E
authors: Riego
authors: S
authors: S
authors: García-Granda
authors: A
authors: A
authors: Forcén-Acebal