The expanding universe of alkaloid biosynthesis.
Characterization of many of the major gene families responsible for the generation of central intermediates and for their decoration, together with the development of large genomics and proteomics databases, has revolutionized our capability to identify exotic and interesting natural-product pathways. Over the next few years, these tools will facilitate dramatic advances in our knowledge of the biosynthesis of alkaloids, which will far surpass that which we have learned in the past 50 years. These tools will also be exploited for the rapid characterization of regulatory genes, which control the development of specialized cell factories for alkaloid biosynthesis.
De Luca
V
V
Institut de Recherche en Biologie Végétale, Département de Sciences Biologiques, Université de Montréal, 4101 rue Sherbrooke est, Montréal, H1X 2B2, Québec, Canada. vince.deluca@syngenta.com
Laflamme
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P
D000166:Acridines / Q000378:metabolism; D000470:Alkaloids / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D019295:Computational Biology; D023281:Genomics; D007211:Indoles / Q000378:metabolism; D007546:Isoquinolines / Q000378:metabolism; D015388:Organelles / Q000378:metabolism; D010944:Plants / Q000378:metabolism*; D020543:Proteome
D000166:Acridines; D000470:Alkaloids; D007211:Indoles; D007546:Isoquinolines; D020543:Proteome