[New platelet inhibitors].
The antiplatelet action of acetylsalicylic acid is mostly used in vascular medicine. In the meantime two other classes of platelet inhibiting agents have been introduced. Thieopyridines (Ticlyridin, Clopidogrel) have been shown to inhibit ADP induced platelet aggregation with persistence of this effect for several days after withdrawal. The short acting intravenous Glycoprotein IIb/IIIa inhibitors considerably improved the management of acute coronacy syndrome. The above mentioned compounds may be applied in combination at least for some days, and heparins are given in addition. Mainly the bleeding complications are to be taken into account especially if patients have to undergo emergency interventions. Hemodialysis or platelet concentrates are recommended to antagonise the antiplatelet effects immediately.
Spannagl
M
M
Medizinische Klinik Innenstadt der LMU, Ziemssenstrasse 1, 80336 München.
Frey
L
L
D000758:Anesthesia; D000818:Animals; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*
D010975:Platelet Aggregation Inhibitors