Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression.
We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection.
Islam
S A
SA
Partners AIDS Research Center & ID Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
Hay
C M
CM
Hartman
K E
KE
He
S
S
Shea
A K
AK
Trocha
A K
AK
Dynan
M J
MJ
Reshamwala
N
N
Buchbinder
S P
SP
Basgoz
N O
NO
Kalams
S A
SA
D002908:Chronic Disease; D002999:Clone Cells; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008137:Longitudinal Studies; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013997:Time Factors
D016693:Receptors, Antigen, T-Cell, alpha-beta