title: Role of chance in familial aggregation of colorectal cancer.
abstract: A prospective population-based study recorded family trees of 77 colorectal cancer patients younger than 50 years of age. Using mathematical modeling of population age-incidence data, we estimate that 1 (95% confidence limits 0 and 3) of these families is expected to meet the Amsterdam criteria I for HNPCC due to chance clustering of colorectal cancer.
authors: Surgical Research Unit 900, Department or Surgery L, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark.
authors: N
authors: N
authors: Katballe
authors: S M
authors: SM
authors: Bentzen
authors: M
authors: M
authors: Christensen
authors: F P
authors: FP
authors: Wikman
authors: T
authors: T
authors: Ørntoft
authors: S
authors: S
authors: Laurberg
mesh_terms: D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D003718:Denmark; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011336:Probability; D011446:Prospective Studies