title: Passive immunization with melanin-binding monoclonal antibodies prolongs survival of mice with lethal Cryptococcus neoformans infection.
abstract: Passive immunization with monoclonal antibodies (MAbs) to melanin prolonged the survival of and reduced the fungal burden in Cryptococcus neoformans-infected mice in comparison to controls. MAbs to melanin reduced the growth rate of in vitro-melanized C. neoformans cells, suggesting a new mechanism of antibody-mediated protection.
authors: Department of Microbiology & Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
authors: A L
authors: AL
authors: Rosas
authors: J D
authors: JD
authors: Nosanchuk
authors: A
authors: A
authors: Casadevall
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D003453:Cryptococcosis / Q000517:prevention & control*; D003455:Cryptococcus neoformans / Q000254:growth & development; D005260:Female; D007116:Immunization, Passive; D007980:Levodopa / Q000494:pharmacology; D008543:Melanins / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL
chemical_list: D000911:Antibodies, Monoclonal; D008543:Melanins; D007980:Levodopa