title: Effect of prenatal exposure to polychlorinated biphenyls on cognitive development in children: a longitudinal study in Taiwan.
abstract: BACKGROUND
  From 1978 to 1979, a group of people in Taiwan were exposed to high levels of heat-degraded polychlorinated biphenyls (PCBs) owing to accidental ingestion of contaminated rice oil. Children born to mothers following the exposure ('Yucheng' children) were known to have hyperpigmented skin and other dysmorphology after birth.
  
  
  OBJECTIVE
  To determine the effect of prenatal exposure to PCBs on cognitive development in Yucheng children.
  
  
  METHODS
  One hundred and eighteen Yucheng children prenatally exposed to PCBs and degradation products, and community-matched control children who were exposed to background levels only, were followed from 1985 to 1998. The Bayley Scale for Infant Development, Chinese version of the Stanford-Binet IQ Test, Raven's Coloured Progressive Matrices and Raven's Standardised Progressive Matrices were used to assess the cognitive development of these children.
  
  
  RESULTS
  The Yucheng children scored lower than control children on each of these methods of measurement between the ages of 2 and 12 years.
  
  
  CONCLUSIONS
  Prenatal exposure to PCBs and their derivatives has long-term adverse effects on cognitive development in humans.
authors: Department of Psychiatry, Chung-Shan Medical and Dental College, Taichung, Taiwan.
authors: T J
authors: TJ
authors: Lai
authors: Y L
authors: YL
authors: Guo
authors: N W
authors: NW
authors: Guo
authors: C C
authors: CC
authors: Hsu
mesh_terms: D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000139:chemically induced*; D002658:Developmental Disabilities / Q000139:chemically induced; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005506:Food Contamination; D006801:Humans; D008137:Longitudinal Studies; D012275:Oryza; D010938:Plant Oils; D011078:Polychlorinated Biphenyls / Q000506:poisoning*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013624:Taiwan
chemical_list: D010938:Plant Oils; D011078:Polychlorinated Biphenyls