Factors affecting the volume of umbilical cord blood collections.
OBJECTIVE
Our purpose was to find factors that may help increase the number of the HSC (CD34+) collected from umbilical cord blood for transplantation.


METHODS
We assessed the effect of cesarean sections and vaginal deliveries on the volume of the umbilical cord blood collected from 155 healthy term neonates retrospectively.


RESULTS
The volume of umbilical cord blood obtained in 29 cesarean deliveries was 103.9 +/- 33.6 ml compared with 84.2 +/- 25.3 ml collected in 126 vaginal deliveries. Although the percentage of CD34+ cells was comparable in both groups, the absolute number of CD34+ cells was significantly higher in the cesarean section group because of the larger volume collected.


CONCLUSIONS
Cesarean sections may allow collection of significantly increased volumes of umbilical cord blood and numbers of CD34+ cells compared to vaginal deliveries.
Yamada
T
T
Department of Pathology, Osaka Medical College, Japan.
Okamoto
Y
Y
Kasamatsu
H
H
Horie
Y
Y
Yamashita
N
N
Matsumoto
K
K
D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis*; D001800:Blood Specimen Collection; D001810:Blood Volume / Q000502:physiology*; D002585:Cesarean Section; D005260:Female; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology; D005434:Flow Cytometry; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D012189:Retrospective Studies
D018952:Antigens, CD34