title: [A case of small cell lung cancer with paraneoplastic cerebellar degeneration and anti-voltage-gated calcium channel antibody].
abstract: A 55-year-old man presenting with 4 weeks of progressive dysarthria, gait ataxia and vertigo was admitted to our hospital. Chest X-ray films revealed a mass shadow in the right upper lobe of the lung, and transbronchial brushing specimens showed small-cell carcinoma. Extensive examination revealed metastatic lesions in the mediastinal lymph nodes and liver, but brain MRI showed no findings suggestive of metastasis or atrophy. A diagnosis of PCD associated with SCLC was made, and the patient had a high titer of anti-P/Q-type VGCC antibody. He was treated by chemotherapy and radiation therapy, which resulted in a transient improvement in the PCD symptoms.
authors: Department of Internal Medicine, Iwamizawa Municipal General Hospital, Iwamizawa.
authors: S
authors: S
authors: Shirai
authors: N
authors: N
authors: Sukoh
authors: H
authors: H
authors: Yamamoto
authors: I
authors: I
authors: Suzuki
authors: A
authors: A
authors: Kamimura
authors: K
authors: K
authors: Yoshida
authors: A
authors: A
authors: Suzuki
authors: M
authors: M
authors: Inoue
authors: N
authors: N
authors: Watanabe
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D020864:Calcium Channels, N-Type / Q000276:immunology*; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy
chemical_list: D001323:Autoantibodies; D020864:Calcium Channels, N-Type