Analysis of slc19a2, on 1q23.3 encoding a thiamine transporter as a candidate gene for type 2 diabetes mellitus in pima indians.
Mutations in the SLC19A2 gene cause thiamine-responsive megaloblastic anemia (TRMA) frequently combined with diabetes mellitus and deafness. Type 2 diabetes mellitus is heritable and a region on 1q21-q23 encompassing SLC19A2 was linked with the disease in Pima Indians and Caucasians. We therefore investigated this candidate gene in selected diabetic and nondiabetic Pimas and found no variants. We conclude that mutations in SLC19A2 do not contribute to type 2 diabetes in this population.
Thameem
F
F
Clinical Diabetes and Nutrition Section, Phoenix Epidemiology and Clinical Research Branch, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, 4212 North 16th Street, Phoenix, Arizona 85016, USA. fthameem@mail.nih.gov
Wolford
J K
JK
Bogardus
C
C
Prochazka
M
M
D000749:Anemia, Megaloblastic / Q000235:genetics; D001130:Arizona; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D017931:DNA Primers / Q000737:chemistry; D003924:Diabetes Mellitus, Type 2 / Q000208:ethnology* / Q000235:genetics; D004198:Disease Susceptibility; D005091:Exons; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D007198:Indians, North American / Q000235:genetics*; D007438:Introns; D026901:Membrane Transport Proteins; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide
D002352:Carrier Proteins; D017931:DNA Primers; D026901:Membrane Transport Proteins; C120043:SLC19A2 protein, human