Accidental busulfan overdose: enhanced drug clearance with hemodialysis in a child with Wiskott-Aldrich syndrome.
A 4.6 kg infant with Wiskott-Aldrich syndrome received an accidental overdose of busulfan during preparation for allogeneic stem cell transplantation. Pharmacokinetic analysis of plasma busulfan levels alerted staff to the dosing error. Hemodialysis was immediately performed and resulted in accelerated clearance of busulfan. There were no acute neurologic and hepatic side-effects of the busulfan overdose, and despite 2 months of cough accompanied by rales, the patient is now free of pulmonary symptoms. Stable partial donor chimerism occurred after transplantation. At present, the patient is thriving and infection-free 12 months after transplantation, although his platelet count remains at the lower limit of normal.
Stein
J
J
Bone Marrow Transplantation Unit, Department of Pediatric Hematology Oncology, Schneider Children's Medical Center of Israel, Petah Tikva, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Davidovitz
M
M
Yaniv
I
I
Ben-Ari
J
J
Gamzu
Z
Z
Hoffer
E
E
Bentur
Y
Y
Tabak
A
A
Krivoy
N
N
D019540:Area Under Curve; D016026:Bone Marrow Transplantation; D002066:Busulfan / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D003371:Cough / Q000139:chemically induced; D062787:Drug Overdose / Q000628:therapy; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008508:Medication Errors; D008657:Metabolic Clearance Rate; D006435:Renal Dialysis; D014923:Wiskott-Aldrich Syndrome / Q000150:complications / Q000628:therapy*
D002066:Busulfan