[A case of small cell lung cancer with paraneoplastic cerebellar degeneration and anti-voltage-gated calcium channel antibody].
A 55-year-old man presenting with 4 weeks of progressive dysarthria, gait ataxia and vertigo was admitted to our hospital. Chest X-ray films revealed a mass shadow in the right upper lobe of the lung, and transbronchial brushing specimens showed small-cell carcinoma. Extensive examination revealed metastatic lesions in the mediastinal lymph nodes and liver, but brain MRI showed no findings suggestive of metastasis or atrophy. A diagnosis of PCD associated with SCLC was made, and the patient had a high titer of anti-P/Q-type VGCC antibody. He was treated by chemotherapy and radiation therapy, which resulted in a transient improvement in the PCD symptoms.
Shirai
S
S
Department of Internal Medicine, Iwamizawa Municipal General Hospital, Iwamizawa.
Sukoh
N
N
Yamamoto
H
H
Suzuki
I
I
Kamimura
A
A
Yoshida
K
K
Suzuki
A
A
Inoue
M
M
Watanabe
N
N
D001323:Autoantibodies / Q000032:analysis*; D020864:Calcium Channels, N-Type / Q000276:immunology*; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D020362:Paraneoplastic Cerebellar Degeneration / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy
D001323:Autoantibodies; D020864:Calcium Channels, N-Type