Praziquantel and  albendazole in the combined treatment of experimental hydatid disease.
The combination of praziquantel and albendazole (PZ + ABZ) used in the present study demonstrated an efficacy of 100% when used as chemoprophylactic treatment because no viable hydatid cysts developed after mice had been injected with protoscolices. However, when the PZ + ABZ combination was used for the treatment of 4-month secondary experimental hydatidosis, no significant difference was found between the control and treated mice, although severe damage to the cyst ultrastructure of the treated mice was observed.
Moreno
M J
MJ
Parasitology Laboratory, Faculty of Pharmacy, University of Alcalá, Madrid, Spain.
Urrea-París
M A
MA
Casado
N
N
Rodriguez-Caabeiro
F
F
D015766:Albendazole / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004443:Echinococcosis / Q000188:drug therapy* / Q000517:prevention & control; D004446:Echinococcus / Q000187:drug effects / Q000254:growth & development / Q000648:ultrastructure; D051379:Mice; D011223:Praziquantel / Q000627:therapeutic use*; D016896:Treatment Outcome
D000871:Anthelmintics; D011223:Praziquantel; D015766:Albendazole