Investigation of brain dynamics in Parkinson's disease by methods derived from nonlinear dynamics.
EEGs were recorded from patients in early stages of Parkinson's disease (17 patients, 9 females) and healthy controls (12 subjects, 8 females) during rest and during execution/imagining of a complex motor task. The prediction that Parkinson's disease patients compared to controls would show more complex brain dynamics during performance of a complex motor task and imagination of the movements was confirmed by methods derived from nonlinear dynamics. In the resting state, analysis of correlation dimension of EEG time series revealed only slight topographical differences between the groups. During performance of a complex motor task, however, data from Parkinson's disease patients showed higher dimensionality than data from controls, indicating more complex EEG time series. The same difference was found when subjects did not perform any motor movements but imagined the complex movements they had just performed. The data are consistent with the hypothesis that the disturbances in Parkinson's disease result in the recruitment of superfluous cortical networks due to failed inhibition of alternative motor programs in the striatum and thus increase the complexity of cortical representation in motor conditions.
Müller
V
V
Institute of Medical Psychology and Behavioral Neurobiology, Eberhard-Karls University of Tübingen, Gartenstrasse 29, 72074 Tübingen, Germany. viktor.mueller@uni-tuebingen.de
Lutzenberger
W
W
Pulvermüller
F
F
Mohr
B
B
Birbaumer
N
N
D000368:Aged; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology*; D003342:Corpus Striatum / Q000473:pathology / Q000503:physiopathology*; D004569:Electroencephalography; D005260:Female; D006801:Humans; D007092:Imagination / Q000502:physiology; D008297:Male; D008875:Middle Aged; D008959:Models, Neurological; D009048:Motor Skills / Q000502:physiology; D009068:Movement / Q000502:physiology*; D009415:Nerve Net / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D009434:Neural Pathways / Q000473:pathology / Q000503:physiopathology*; D009483:Neuropsychological Tests; D017711:Nonlinear Dynamics; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology*; D011237:Predictive Value of Tests; D011597:Psychomotor Performance / Q000502:physiology