Metabolism of tyrosine and tryptophan--new genes for old pathways.
Tyrosine and tryptophan are precursors for the plant defense compounds dhurrin and indole glucosinolates, respectively. In addition, tryptophan is a precursor for the essential phytohormone indole-3-acetic acid. Recent advances in understanding the biosynthesis of these compounds have come from the characterization of enzymes that catalyze the N-hydroxylation of the precursor amino acid to the oxime intermediate. Furthermore, enzymes catalyzing subsequent biosynthetic steps have also been identified.
Celenza
J L
JL
Boston University, Department of Biology, 5 Cummington Street, 02215, Boston, Massachusetts, USA. celenza@bu.edu
D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism; D005960:Glucosides / Q000378:metabolism; D005961:Glucosinolates / Q000378:metabolism; D006900:Hydroxylation; D007210:Indoleacetic Acids / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000235:genetics / Q000378:metabolism; D009570:Nitriles / Q000378:metabolism; D010091:Oximes / Q000378:metabolism*; D010937:Plant Growth Regulators / Q000378:metabolism; D010940:Plant Proteins / Q000378:metabolism; D014364:Tryptophan / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism*
D005960:Glucosides; D005961:Glucosinolates; D007210:Indoleacetic Acids; D009570:Nitriles; D010091:Oximes; D010937:Plant Growth Regulators; D010940:Plant Proteins; C023476:indole-3-aldehyde oxime; D014443:Tyrosine; C030737:indoleacetic acid; D014364:Tryptophan; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C089817:cytochrome P450TYR; C011220:dhurrin