title: Actin-based motility: stop and go with Ena/VASP proteins.
abstract: Proteins of the Ena/VASP (Enabled/vasodilator-stimulated phosphoprotein) family are involved in Abl and/or cyclic nucleotide-dependent protein kinase signaling pathways. These proteins are also crucial factors in regulating actin dynamics and associated processes such as cell-cell adhesion, platelet function and actin-based motility of both cytopathogenic Listeria and their eukaryotic host cells. Although biochemical mechanisms have emerged depicting Ena/VASP proteins as enhancers of actin filament formation, increasing evidence also suggests that these proteins have inhibitory functions in integrin regulation, cell motility and axon guidance.
authors: Institut für Klinische Biochemie und Pathobiochemie, Klinikum der Universität Würzburg, Versbacher Str. 5, D-97078, Würzburg, Germany. Matthias.Reinhard@klin-biochem.uni-wuerzberg.de
authors: M
authors: M
authors: Reinhard
authors: T
authors: T
authors: Jarchau
authors: U
authors: U
authors: Walter
mesh_terms: D000199:Actins / Q000502:physiology*; D000818:Animals; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000378:metabolism / Q000502:physiology*; D002465:Cell Movement / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000378:metabolism / Q000502:physiology*; D008840:Microfilament Proteins; D010750:Phosphoproteins / Q000378:metabolism / Q000502:physiology*; D010766:Phosphorylation; D000098662:Vasodilator-Stimulated Phosphoprotein
chemical_list: D000199:Actins; D015815:Cell Adhesion Molecules; D004268:DNA-Binding Proteins; C092744:ENA-VASP proteins; D008840:Microfilament Proteins; D010750:Phosphoproteins; D000098662:Vasodilator-Stimulated Phosphoprotein