Association analysis of somatostatin receptor (SSTR1 and SSTR2) polymorphisms in breast cancer and solar keratosis.
The presence of somatostatin receptors (SSTR1-5) in tumour cells indicates a potential for somatostatin to bind and suppress growth, as well as allowing for therapeutic treatment with somatostatin analogues. The genes for SSTR1 and SSTR2 have been shown to contain dinucleotide repeat polymorphisms. We have performed association studies on breast cancer and solar keratosis populations to determine whether these genes play a role in the development of these conditions. Results showed that there was no significant difference between SSTR1 and SSTR2 polymorphism frequencies in the tested breast cancer population (P = 0.59 and P = 0.54, respectively) nor the solar keratosis population (P = 0.10 and P = 0.883, respectively) as compared to unaffected populations. Hence, these studies do not support a role for these receptor genes in either breast cancer or solar keratosis lesions.
Carless
M A
MA
Genomics Research Centre, Griffith University Gold Coast, Queensland, Southport, Australia.
Curran
J E
JE
Gaffney
P
P
Weinstein
S R
SR
Griffiths
L R
LR
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005838:Genotype; D006801:Humans; D007642:Keratosis / Q000235:genetics*; D011110:Polymorphism, Genetic; D017481:Receptors, Somatostatin / Q000235:genetics*; D013472:Sunlight; D020080:Tandem Repeat Sequences
D017481:Receptors, Somatostatin