Compliance, satisfaction, and quality of life of patients with colorectal cancer receiving home chemotherapy or outpatient treatment: a randomised controlled trial.
OBJECTIVE
To compare chemotherapy given at home with outpatient treatment in terms of colorectal cancer patients' safety, compliance, use of health services, quality of life, and satisfaction with treatment.


METHODS
Randomised controlled trial.


METHODS
Large teaching hospital.


METHODS
87 patients receiving adjuvant or palliative chemotherapy for colorectal cancer.


METHODS
Treatment with fluorouracil (with or without folinic acid or levamisole) at outpatient clinic or at home.


METHODS
Treatment toxicity; patients' compliance with treatment, quality of life, satisfaction with care, and use of health resources.


RESULTS
42 patients were treated at outpatient clinic and 45 at home. The two groups were balanced in terms of age, sex, site of cancer, and disease stage. Treatment related toxicity was similar in the two groups (difference 7% (95% confidence interval -12% to 26%)), but there were more voluntary withdrawals from treatment in the outpatient group than in the home group (14% v 2%, difference 12% (1% to 24%)). There were no differences between groups in terms of quality of life scores during and after treatment. Levels of patient satisfaction were higher in the home treatment group, specifically with regard to information received and nursing care. There were no significant differences in use of health services.


CONCLUSIONS
Home chemotherapy seemed an acceptable and safe alternative to hospital treatment for patients with colorectal cancer that may improve compliance and satisfaction with treatment.
Borras
J M
JM
Cancer Prevention and Control Unit, Catalan Institute of Oncology, Gran Via Km 2,7 s/n, 08907-Hospitalet, Spain. jmborras@ico.scs.es
Sanchez-Hernandez
A
A
Navarro
M
M
Martinez
M
M
Mendez
E
E
Ponton
J L
JL
Espinas
J A
JA
Germa
J R
JR
D000553:Ambulatory Care / Q000592:standards*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015179:Colorectal Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006699:Home Care Services / Q000592:standards*; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D010342:Patient Acceptance of Health Care; D010349:Patient Compliance; D017060:Patient Satisfaction; D011788:Quality of Life; D011795:Surveys and Questionnaires
D002955:Leucovorin; D005472:Fluorouracil