title: Clinical and immunological features of patients with interleukin-5-producing T cell clones and eosinophilia.
abstract: Recent work suggests that in some patients with the hypereosinophilic syndrome, a clone of abnormal T cells produces large amounts of interleukin-5. In this study, we examined 60 patients with idiopathic eosinophilia. Sixteen patients had circulating T cells with an aberrant immunophenotype that, in most cases, were associated with different forms of skin inflammation. The abnormal T cells produced large amounts of interleukin-5, which may have increased eosinophil differentiation in the bone marrow of these patients.
authors: Department of Pharmacology, University of Bern, Switzerland. hus@pki.unibe.ch
authors: H U
authors: HU
authors: Simon
authors: S G
authors: SG
authors: Plötz
authors: D
authors: D
authors: Simon
authors: R
authors: R
authors: Dummer
authors: K
authors: K
authors: Blaser
mesh_terms: D002999:Clone Cells; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000276:immunology* / Q000473:pathology*; D016130:Immunophenotyping; D015848:Interleukin-5 / Q000096:biosynthesis*; D016131:Lymphocyte Subsets / Q000145:classification; D016399:Lymphoma, T-Cell / Q000209:etiology; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015848:Interleukin-5