title: Invasive Group C Streptococcus infection associated with rhabdomyolysis and disseminated intravascular coagulation in a previously healthy adult.
abstract: Infections with Group C Streptococci can lead to severe disease, particularly in individuals with underlying illnesses such as cardiovascular disease, malignancy or immunosuppression. We report the first case of rhabdomyolysis and disseminated intravascular coagulation secondary to Group C Streptococcus in a previous healthy male. A toxic shock-like syndrome associated with Group C and Group G Streptococci has been reported. However, unlike with Group A Streptococci, production of endotoxins by these organisms is less well defined. We tested the patient's isolate for its ability to produce superantigenic toxins and to induce a mitogenic response. Although it is not known whether Group C Streptococci require special growth conditions for the production of superantigens, we could not demonstrate either the production of exotoxins or the induction of a mitogenic response.
authors: Department of Pediatrics, University of Rochester, School of Medicine and Dentistry, New York, NY 14642, USA.
authors: I C
authors: IC
authors: Ojukwu
authors: D W
authors: DW
authors: Newton
authors: A E
authors: AE
authors: Luque
authors: M Y
authors: MY
authors: Kotb
authors: M
authors: M
authors: Menegus
mesh_terms: D000328:Adult; D016470:Bacteremia / Q000150:complications / Q000382:microbiology; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D005098:Exotoxins / Q000096:biosynthesis; D006801:Humans; D008297:Male; D012206:Rhabdomyolysis / Q000150:complications*; D012772:Shock, Septic / Q000150:complications; D013290:Streptococcal Infections / Q000150:complications* / Q000175:diagnosis / Q000382:microbiology; D013291:Streptococcus / Q000302:isolation & purification* / Q000378:metabolism
chemical_list: D005098:Exotoxins