title: Oxybutynin does not affect cyclosporin blood levels.
abstract: Cyclosporin is an important immunosuppressive medication used to prevent organ rejection. Drug interactions that alter its blood levels can cause serious problems with toxicity or transplant rejection. Current evidence indicates that both cyclosporin and oxybutynin, which is used to treat bladder dysfunction, are metabolized by the cytochrome P450 3A enzyme system, raising the possibility of an adverse interaction between these medications. However, a study of two children receiving cyclosporin with and without oxybutynin revealed no significant changes in trough blood cyclosporin concentrations.
authors: Department of Pediatrics, School of Medicine and Biomedical Sciences, State University of New York at Buffalo, USA.
authors: J E
authors: JE
authors: Springate
mesh_terms: D002648:Child; D002675:Child, Preschool; D018680:Cholinergic Antagonists / Q000009:adverse effects*; D016572:Cyclosporine / Q000097:blood*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood*; D008297:Male; D008333:Mandelic Acids / Q000009:adverse effects*
chemical_list: D018680:Cholinergic Antagonists; D007166:Immunosuppressive Agents; D008333:Mandelic Acids; D016572:Cyclosporine; C005419:oxybutynin