Cloning and expression of CSAL2, a new member of the spalt gene family in chick.
In this study we describe cloning and expression of CSAL2, a second member of the spalt gene family in chick. All spalt proteins are characterized by the presence of multiple zinc-finger motifs, which are highly conserved. Mutations in HSAL1, a human spalt gene result in Townes-Brocks syndrome (TBS). We show here that CSAL2 is expressed in many of the tissues affected in TBS, including neural tissue, limb buds, mesonephros and cloaca.
Farrell
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School of Life Sciences Biocentre, Division of Cell and Developmental Biology, University of Dundee, Wellcome Trust Biocenter, Dow Street, DD 1 5EH, Dundee, UK.
Tosh
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Church
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Münsterberg
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AE
D000595:Amino Acid Sequence; D000818:Animals; D002490:Central Nervous System / Q000196:embryology; D002642:Chick Embryo; D003001:Cloning, Molecular; D005121:Extremities / Q000196:embryology; D018398:Homeodomain Proteins / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D017386:Sequence Homology, Amino Acid; D013623:Tail / Q000196:embryology; D014157:Transcription Factors / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics*; D014981:Xenopus; D029867:Xenopus Proteins; D016335:Zinc Fingers
D018398:Homeodomain Proteins; C484467:Sall3 protein, mouse; D014157:Transcription Factors; D029867:Xenopus Proteins; C103405:sal1-A protein, Xenopus; C484468:spalt protein, vertebrate