Inhalation studies with the Göttingen minipig.
A method for inhalative exposure of minipigs to aerosols and gases has been developed. Minipigs are exposed via mask inhalation to the test substance using a computer-controlled exposure system that permits simultaneous exposure of groups of four animals in parallel to different controlled dose levels. We studied inhalation treatment of verapamil, a cardiovascular drug, and show good absorption and favorable pharmacokinetics when compared with iv drug application. The results shown in this study encourage inhalation studies with the Göttingen minipig.
Koch
W
W
Fraunhofer-Institute of Toxicology and Aerosol Research, Nikolai-Fuchs-Str. 1, D-30625 Hannover, Germany. koch@ita.fhg.de
Windt
H
H
Walles
M
M
Borlak
J
J
Clausing
P
P
D000336:Aerosols; D000818:Animals; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D018592:Cross-Over Studies; D005260:Female; D019570:Inhalation Exposure; D007275:Injections, Intravenous; D008168:Lung / Q000502:physiology; D008297:Male; D013552:Swine; D013556:Swine, Miniature / Q000378:metabolism*; D014700:Verapamil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000336:Aerosols; D002121:Calcium Channel Blockers; D014700:Verapamil