Molecular genetic analysis of the calcineurin signaling pathways.
Calcineurin is a Ca2+- and calmodulin-regulated protein phosphatase that is important in Ca2+-mediated signal transduction. Recent application of the powerful techniques of molecular genetics has demonstrated that calcineurin is involved in the regulation of critical biological processes such as T cell activation, muscle hypertrophy, memory development, glucan synthesis, ion homeostasis, and cell cycle control. Notably, specific transcription factors have been shown to play a key role in regulating these functions, and their calcineurin-mediated dephosphorylation and nuclear translocation appear to be a central event in the signal transduction pathways. This review focuses on recent progress in these areas and discusses the evidence for cross-talk between calcineurin and other signaling pathways.
Sugiura
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Department of Pharmacology, Kobe University School of Medicine, Japan.
Sio
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Shuntoh
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Kuno
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D000818:Animals; D019703:Calcineurin / Q000378:metabolism*; D006332:Cardiomegaly / Q000378:metabolism; D002453:Cell Cycle; D005936:Glucans / Q000096:biosynthesis; D006801:Humans; D006984:Hypertrophy; D017136:Ion Transport; D008213:Lymphocyte Activation; D008568:Memory; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D008967:Molecular Biology; D018482:Muscle, Skeletal / Q000378:metabolism / Q000473:pathology; D009473:Neuronal Plasticity; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D005936:Glucans; D014157:Transcription Factors; D020928:Mitogen-Activated Protein Kinases; D019703:Calcineurin