Hemolytic uremic syndrome with intracranial hemorrhage following mitomycin C administration.
A 50-year-old woman treated for breast cancer with mitomycin C developed severe hypertension, followed by deep coma 3 days later. Computed tomography of the brain showed frontoparietal intracranial hemorrhage accompanied by subarachnoid hemorrhage. The patient was diagnosed additionally with hemolytic uremic syndrome (HUS) based on hemolytic anemia with schistocytosis, thrombocytopenia, and acute renal failure. The patient underwent hemodialysis and plasmapheresis with no improvement. We present the pathologic findings of the general vessels, which has been reported rarely. This case represents the first reported intracranial hemorrhage in HUS following mitomycin C administration. We emphasize the need to control blood pressure in patients with HUS.
Nishiyama
Y
Y
Second Department of Internal Medicine, Nippon Medical School, Tokyo.
Komaba
Y
Y
Kitamura
H
H
Katayama
Y
Y
D000477:Alkylating Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000473:pathology; D006801:Humans; D020300:Intracranial Hemorrhages / Q000139:chemically induced* / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D016685:Mitomycin / Q000009:adverse effects* / Q000627:therapeutic use
D000477:Alkylating Agents; D016685:Mitomycin