Synthesis of a new fluoro-Wang resin for solid-phase reaction monitoring by 19F NMR spectroscopy.
A new fluoro-Wang resin is presented which facilitates solid-phase reaction monitoring using 19F NMR. The resin is easily synthesized and amenable to scale-up. The method described herein compliments single-bead FT-IR and 13C NMR techniques. This method allows monitoring of solid-phase reactions even if the resin bound intermediate is unstable to the cleavage conditions. In addition, this is a useful tool to study reaction kinetics on the solid phase.
Salvino
J M
JM
Lead Discovery Department, Rhone Poulenc Rorer, 500 Arcola Road, Collegeville, Pennsylvania 19426, USA.
Patel
S
S
Drew
M
M
Krowlikowski
P
P
Orton
E
E
Kumar
N V
NV
Caulfield
T
T
Labaudiniere
R
R