title: Idiopathic hypereosinophilic syndrome in 3 Rottweilers.
abstract: Three Rottweilers with marked peripheral eosinophilia and infiltration of the liver, spleen, lungs, and bone marrow with eosinophils were diagnosed with idiopathic hypereosinophilic syndrome (IHES). Mean serum immunoglobulin E concentrations were markedly high. On cytogenetic analysis, no evidence of karyotypic abnormalities was found in bone marrow aspirates. Despite an extensive search, no underlying cause for the eosinophilia could be identified. In this study, cytogenetic analysis and measurement of serum IgE concentrations were used to differentiate IHES and eosinophilic leukemia.
authors: Department of Small Animal Clinical Sciences, University of Minnesota, St Paul 55108, USA. sykes005@tc.umn.edu
authors: J E
authors: JE
authors: Sykes
authors: D J
authors: DJ
authors: Weiss
authors: L C
authors: LC
authors: Buoen
authors: M M
authors: MM
authors: Blauvelt
authors: D W
authors: DW
authors: Hayden
mesh_terms: D000818:Animals; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D017681:Hypereosinophilic Syndrome / Q000175:diagnosis / Q000662:veterinary*; D007073:Immunoglobulin E / Q000097:blood; D007621:Karyotyping; D008297:Male
chemical_list: D007073:Immunoglobulin E