Dual presentation of extranodal marginal B-cell lymphoma involving the skin, viscera and bones.
A 65-year-old man presented with an erythematous indurated plaque on the scalp and forehead. A low-grade marginal-zone B-cell lymphoma with small cells and kappa-chain monoclonality was diagnosed. Radiotherapy was initiated. He soon developed abdominal pain and hematemesis. A high-grade marginal-zone B-cell lymphoma with large cells and lambda-chain predominance was disclosed infiltrating the stomach and lungs. Bone localizations were also found. There was no evidence for lymph node and bone marrow involvement. The distinct cytological and immunophenotypic presentations in the skin and viscera are a puzzling finding.
Uhoda
I
I
Department of Dermatology, Centre Hospitalier Régional Hutois, Huy, Belgium.
Piérard-Franchimont
C
C
Arrese
J E
JE
Piérard
G E
GE
D000368:Aged; D001859:Bone Neoplasms / Q000473:pathology*; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology*; D018442:Lymphoma, B-Cell, Marginal Zone / Q000175:diagnosis / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*