Starvation-induced pathobiology in the gut of carp (Cyprinus carpio L.).
In order to assess the effects of starvation on intestinal intraepithelial lymphocytes (i-IEL) count and histological changes of the carp gut mucosa, one group of fish (n = 10) were fed commercially prepared standard diets and another group of fish (n = 10) were starved for 4 weeks. Carp starved for 4 weeks developed enteropathy, comprising folds atrophy, stratum compactum hyperplasia, significant periodic-acid-Schiff (PAS)-positive (P < 0.00001), but not Alcian blue (ALB)-positive, goblet cell (GC) hyperplasia and a significant decrease (P < 0.00001) in i-IEL numbers. These changes were associated with a dense cellular infiltrate into the lamina propria. Taken together, these data suggest that the pathobiology of starvation-induced i-IELs decrease, matching PAS-positive goblet cell proliferation and inflammatory cells homing to the gut, could be classified as a non-infectious enteropathy induced by starvation.
Bozić
F
F
Department of Pharmacology & Toxicology, Veterinary Faculty, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia. Bozic@mavef.vef.hr
Srebocan
E
E
Kozarić
Z
Z
D000818:Animals; D002347:Carps; D005393:Fish Diseases / Q000276:immunology / Q000473:pathology*; D007422:Intestines / Q000276:immunology / Q000473:pathology*; D018655:Lymphocyte Count / Q000662:veterinary; D013217:Starvation / Q000276:immunology / Q000473:pathology / Q000662:veterinary*