Three-dimensional contrast-enhanced MRI using an intravascular contrast agent for detection of traumatic intra-abdominal hemorrhage and abdominal parenchymal injuries: an experimental study.
The aim of this study was to compare the performance of 3D MRI in conjunction with an intravascular contrast agent to spiral contrast-enhanced CT, regarding the detection of abdominal parenchymal injuries as well as peritoneal hemorrhage in an animal model. Liver and kidney injuries were created surgically in six female pigs under general anesthesia. All pigs underwent contrast-enhanced spiral CT and 3D MR imaging following administration of an intravascular contrast agent (NC100150 Injection). Two readers rated their confidence independently on MR and CT data sets using a five-point scale for the presence of organ injury and hemoperitoneum. Autopsy findings served as standard of reference. Sensitivity and specificity for MR in detecting hepatic and renal injuries as well as hemoperitoneum was 100%. Computed tomography was less accurate with sensitivity and specificity values of 90 and 94%, respectively. Receiver operating characteristics (ROC) analysis revealed a higher confidence when interpretation was based on MR images. In an animal model 3D MR imaging in conjunction with an intravascular contrast agent proved highly accurate in detecting and localizing parenchymal injuries to the upper abdomen as well as in detecting intraperitoneal blood collections.
Weishaupt
D
D
Institute of Diagnostic Radiology, University Hospital Zurich, Switzerland.
Hetzer
F H
FH
Ruehm
S G
SG
Patak
M A
MA
Schmidt
M
M
Debatin
J F
JF
D000007:Abdominal Injuries / Q000150:complications / Q000175:diagnosis* / Q000000981:diagnostic imaging; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D003911:Dextrans; D005260:Female; D052203:Ferrosoferric Oxide; D006465:Hemoperitoneum / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000209:etiology; D021621:Imaging, Three-Dimensional; D007275:Injections, Intravenous; D007501:Iron / Q000008:administration & dosage; D007668:Kidney / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D008099:Liver / Q000000981:diagnostic imaging / Q000293:injuries* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D058185:Magnetite Nanoparticles; D010087:Oxides / Q000008:administration & dosage; D012372:ROC Curve; D011860:Radiography, Abdominal; D013552:Swine; D014057:Tomography, X-Ray Computed
D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; C097921:ferumoxtran-10; D007501:Iron; D052203:Ferrosoferric Oxide