Genomic scan for genes affecting body composition before and after training in Caucasians from HERITAGE.
An autosomal genomewide search for genes related to body composition and its changes after a 20-wk endurance-exercise training program has been completed in the HERITAGE Family Study. Phenotypes included body mass index (BMI), sum of eight skinfold thicknesses, fat mass (FM), fat-free mass, percent body fat (%Fat), and plasma leptin levels. A maximum of 364 sib-pairs from 99 Caucasian families was studied with the use of 344 markers with single-point and multipoint linkage analyses. Evidence of significant linkage was observed for changes in fat-free mass with the S100A and the insulin-like growth factor I genes (P = 0.0001). Suggestive evidence (2.0 < or = Lod < 3.0; 0.0001 < P < or = 0.001) was also observed for the changes in FM and %Fat at 1q31 and 18q21-q23, in %Fat with the uncoupling protein 2 and 3 genes, and in BMI at 5q14-q21. At baseline, suggestive evidence was observed for BMI at 8q23-q24, 10p15, and 14q11; for FM at 14q11; and for plasma leptin levels with the low-density lipoprotein receptor gene. This is the first genomic scan on genes involved in exercise-training-induced changes in body composition that could provide information on the determinants of weight loss.
Chagnon
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Department of Social and Preventive Medicine and Kinesiology, Laval University, Ste. Foy, Quebec, Canada G1K 7P4. Yvon.Chagnon@kin.msp.ulaval.ca
Rice
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Pérusse
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Borecki
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Ho-Kim
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Lacaille
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Paré
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Bouchard
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Gagnon
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Leon
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Skinner
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Wilmore
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Rao
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Bouchard
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D000273:Adipose Tissue / Q000033:anatomy & histology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001823:Body Composition / Q000235:genetics* / Q000502:physiology; D015992:Body Mass Index; D001835:Body Weight; D002170:Canada; D002874:Chromosome Mapping; D015444:Exercise / Q000502:physiology*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D020738:Leptin / Q000097:blood; D008126:Lod Score; D008297:Male; D018895:Microsatellite Repeats; D008875:Middle Aged; D009679:Nuclear Family; D010809:Physical Fitness; D011973:Receptors, LDL / Q000235:genetics; D012727:Sex Characteristics; D012885:Skinfold Thickness; D014481:United States; D044465:White People / Q000235:genetics*
D005819:Genetic Markers; D020738:Leptin; D011973:Receptors, LDL