2,2-Dimethyl-2H-anthra[2,3-b]pyran-6,11-diones: a new class of cytotoxic compounds.
The synthesis and cytotoxic activity of some new 2,2-dimethyl-2H-anthra[2,3-b]pyran-6,11-diones is described. Certain compounds possess interesting activity against murine leukemia L-1210 cells. Relationships between the biological activity and the pyrano-ring conformations are discussed.
Melliou
E
E
Laboratory of Pharmacognosy, University of Athens, Greece.
Magiatis
P
P
Mitaku
S
S
Skaltsounis
A L
AL
Pierré
A
A
Atassi
G
G
Renard
P
P
D000818:Animals; D000873:Anthracenes / Q000138:chemical synthesis / Q000494:pharmacology; D000880:Anthraquinones / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005434:Flow Cytometry; D020128:Inhibitory Concentration 50; D051379:Mice; D008958:Models, Molecular; D011714:Pyrans / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000873:Anthracenes; D000880:Anthraquinones; D000970:Antineoplastic Agents; D011714:Pyrans