Distribution of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptor mRNAs in the rat brain.
The precise involvement of 5-ht(5A), 5-ht(5B), 5-ht(6) and 5-HT(7) receptors in the pleiotropic actions of 5-HT remain incompletely known. To gain insights into their physiological function(s), localization of mRNAs encoding these subtypes was carried out using in situ hybridization on rat brain sections. Localization was heterogeneous. For example, 5-ht(5A) mRNA was widely expressed while 5-ht(5B) mRNA was predominantly expressed in habenula, hippocampus and inferior olive. 5-ht(6) mRNA was abundant in olfactory tubercles and caudate putamen, and highest levels of 5-HT(7) mRNA were observed in multiple thalamic nuclei. These data suggest that these receptors may have distinct functional roles within the serotonergic system.
Kinsey
A M
AM
Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre, Terling's Park, Eastwick Road, Harlow, Essex CM20 2QR, UK.
Wainwright
A
A
Heavens
R
R
Sirinathsinghji
D J
DJ
Oliver
K R
KR
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D015870:Gene Expression / Q000502:physiology; D019262:Habenula / Q000737:chemistry / Q000502:physiology; D006624:Hippocampus / Q000737:chemistry / Q000502:physiology; D017403:In Situ Hybridization; D008297:Male; D017072:Neostriatum / Q000737:chemistry / Q000502:physiology; D009833:Olfactory Pathways / Q000737:chemistry / Q000502:physiology; D009847:Olivary Nucleus / Q000737:chemistry / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000032:analysis / Q000235:genetics*
D012333:RNA, Messenger; D011985:Receptors, Serotonin; C078730:serotonin 5 receptor; C097216:serotonin 6 receptor; C104425:serotonin 7 receptor