About 8- and approximately 84-h rhythms in endotheliocytes as in endothelin-1 and effect of trauma.
Population densities (PD) of capillaries (C) and endotheliocytes (E) were determined in pinnal dermis of C57BL mice before and after trauma. Moving (and overall) least-squares spectra before trauma detected in EPD (versus CPD) pronounced 3.5-day (circasemiseptan) and 8-h oscillations corresponding to components of the endothelin-1 chronome in human blood plasma reported earlier. Circadians were more pronounced in CPD. After trauma, circasemiseptan oscillations appeared also in CPD; their period gradually shortened and in two weeks split into about 2.5- and about 4.5-day oscillations; and circadian components became very pronounced. The pre-traumatic chronome was not restored within three weeks following trauma.
Katinas
G S
GS
Department of Morphology, Yaroslav the Wise Novgorod State University, Novgorod, Russia.
Halberg
F
F
Cornélissen
G
G
Hawkins
D
D
Bueva
M V
MV
Korzhevsky
D E
DE
Sapozhnikova
L R
LR
Rhodus
N
N
Schaffer
E
E
D000818:Animals; D019332:Endothelin-1 / Q000378:metabolism*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010507:Periodicity; D014945:Wound Healing; D014947:Wounds and Injuries / Q000378:metabolism*
D019332:Endothelin-1