New 3'-deoxythymidines bearing a nucleophilic 3'-substituent.
New potential cancer-driven as well as HIV-driven nucleoside heteroanalogs, such as 3'-thio- and 3'- as well as 5'-selenosubstituted thymidines, have been synthesized. We also report an effective method for the preparation of novel nucleoside derivatives, bis(deoxynucleoside) diselenides, in nearly quantitative yields. The North conformation is significantly populated in the conformational equilibrium for 3'-alpha-alkylthiothymidines.
Belostotskii
A M
AM
Chemistry Department, Bar-Ilan University, Ramat-Gan, Israel.
Keren-Yeshuah
H
H
Lexner
J
J
Hassner
A
A
D019380:Anti-HIV Agents / Q000138:chemical synthesis*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009942:Organometallic Compounds / Q000138:chemical synthesis; D012643:Selenium; D013936:Thymidine / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012643:Selenium; D013936:Thymidine