title: Environmental associations with eczema in early life.
abstract: BACKGROUND
  Although atopic eczema (AE) is a common disease, little is known about its causes.
  
  
  OBJECTIVE
  To investigate the role of dietary and environmental factors associated with the development of AE by the age of 2 years.
  
  
  METHODS
  A cohort of children was recruited before birth from a consecutive series of newly pregnant mothers presenting for antenatal care at three general practices in Ashford, Kent, U.K. Data up to the age of 2 years were available for 624 (97%) of the original cohort. AE was defined using components of the U.K. diagnostic criteria for AE, maternal report of doctor-diagnosed eczema and maternally reported eczema. Exposures of interest were family history of allergic disease, dietary and breastfeeding patterns, family size and exposure to indoor domestic allergens.
  
  
  RESULTS
  The cumulative prevalence of AE using the U.K. diagnostic criteria was 14% (95% confidence interval, CI 11-17%). The prevalence of maternally reported doctor-diagnosed eczema was much higher (31%, 95% CI 27-35%) and almost half (45%) the mothers reported that their child had ever had eczema (95% CI 41-49%). The relationship between parental atopy, parental history of allergic disease and the child's eczema was consistently stronger for the mothers than the fathers. There was a marked increase in the prevalence of eczema with increasing maternal education and in less crowded homes, associations that remained significant after controlling for other factors.
  
  
  CONCLUSIONS
  The associations with environmental factors are consistent with the hypothesis that more crowded houses, increased family size and birth order, which may possibly increase early exposure to infections, may offer protection from subsequent development of eczema.
authors: Department of Occupational and Environmental Medicine, Imperial College of Science and Technology (National Heart and Lung Institute), 1b Manresa Road, London SW3 6LR, UK. jessica.harris@ic.ac.uk
authors: J M
authors: JM
authors: Harris
authors: P
authors: P
authors: Cullinan
authors: H C
authors: HC
authors: Williams
authors: P
authors: P
authors: Mills
authors: S
authors: S
authors: Moffat
authors: C
authors: C
authors: White
authors: A J
authors: AJ
authors: Newman Taylor
mesh_terms: D000328:Adult; D003876:Dermatitis, Atopic / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D004032:Diet / Q000009:adverse effects; D004522:Educational Status; D004739:England / Q000453:epidemiology; D004777:Environment; D005191:Family Characteristics; D005260:Female; D005500:Follow-Up Studies; D006798:Housing; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics; D007223:Infant; D007227:Infant Nutritional Physiological Phenomena; D007231:Infant, Newborn; D008297:Male; D009035:Mothers; D010290:Parents; D015995:Prevalence; D011446:Prospective Studies; D012307:Risk Factors; D012923:Social Class