Covalently induced activation of the delta opioid receptor by a fluorogenic affinity label, 7'-(phthalaldehydecarboxamido)naltrindole (PNTI).
Le Bourdonnec
B
B
Department of Medicinal Chemistry, College of Pharmacy, University of Minnesota, Minneapolis, Minnesota 55455, USA.
El Kouhen
R
R
Poda
G
G
Law
P Y
PY
Loh
H H
HH
Ferguson
D M
DM
Portoghese
P S
PS
D000345:Affinity Labels / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D000700:Analgesics / Q000138:chemical synthesis / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D016466:CHO Cells; D006224:Cricetinae; D005456:Fluorescent Dyes / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects / Q000502:physiology; D066298:In Vitro Techniques; D008024:Ligands; D008297:Male; D051379:Mice; D008958:Models, Molecular; D009271:Naltrexone / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D017465:Receptors, Opioid, delta / Q000819:agonists* / Q000378:metabolism; D014649:Vas Deferens / Q000187:drug effects / Q000502:physiology
C424722:17-(cyclopropylmethyl)-4,5-epoxy-3,4-dihydroxy-6-((phthalaldehydecarboxamido)acetamido)morphinan; D000345:Affinity Labels; D000700:Analgesics; D005456:Fluorescent Dyes; D008024:Ligands; D017465:Receptors, Opioid, delta; D009271:Naltrexone