A novel antivirally active fucan sulfate derived from an edible brown alga, Sargassum horneri.
A novel fucan sulfate (Hor-1) was isolated from the hot water extract of an edible brown alga, Sargassum horneri (Turner) C. Agardh. The fucan sulfate was revealed to have sugar linkage types, sulfate content and uronic acid content different from those of sodium hornan (Na-HOR), another fucan sulfate isolated from this alga. However, it exhibited inhibitory activity against replication of herpes simplex virus type 1 with similar potency to Na-HOR.
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Faculty of Pharmaceutical Sciences, Tovama Medical and Pharmaceutical University, Sugitani, Japan.
Hayashi
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K
Lee
J B
JB
Sankawa
U
U
Hayashi
T
T
D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002241:Carbohydrates / Q000737:chemistry; D002850:Chromatography, Gel; D018259:Herpesvirus 1, Human / Q000187:drug effects; D000459:Phaeophyceae / Q000737:chemistry*; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000998:Antiviral Agents; D002241:Carbohydrates; D011134:Polysaccharides; C007789:fucoidan