Repeated electroconvulsive shock treatment induces two humoral anti-depressive factors in mouse.
Forced swimming is considered a depression model. Repeated electroconvulsive shock treatment shows an anti-depressive effect in mice forced swimming. In serum of the mice treated with repeated electroconvulsive shock, the humoral anti-depressive factors were detected. The factors were the glycolipid having GalNAc alpha1-3GalNAc and mouse fibrinopeptide A having amino acid sequence TDTEKDGEFLSGGGV. The behavioral anti-depressive activity of the glycolipid was decreased by the low doses (100 to approximately 10 microg/kg) of dopamine 2 receptor antagonist sulpiride. Behavioral activity of the peptide was also decreased by the low doses (100 to approximately 1 microg/kg) of dopamine 1 receptor antagonist SCH-23390. The present findings clearly indicate that repeated electroconvulsive shock treatment induces the humoral anti-depressive factors affecting the dopaminergic neuronal system in mice.
Masuda
Y
Y
Department of Neuropsychiatry, Akita University School of Medicine, Japan.
Suzuki
M
M
D000595:Amino Acid Sequence; D000818:Animals; D000928:Antidepressive Agents / Q000302:isolation & purification / Q000378:metabolism*; D003863:Depression / Q000378:metabolism / Q000628:therapy*; D004195:Disease Models, Animal; D004565:Electroconvulsive Therapy; D004597:Electroshock; D005344:Fibrinopeptide A / Q000302:isolation & purification / Q000378:metabolism*; D006017:Glycolipids / Q000302:isolation & purification / Q000378:metabolism*; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data
D000928:Antidepressive Agents; D006017:Glycolipids; D005344:Fibrinopeptide A