[Pathogenic role of free-radical damage in radiation-induced atherosclerosis].
According clinico-epidemiological and experimental data there are positive correlation between irradiation and risk of atherosclerosis development. Taking into account that primary physico-chemical effects of ionising radiation influences on organism were connected with biologically active free-radical and their products formation, its pathogenic role under radiation-induced atherosclerotic injures of cardiovascular system is postulate. The development of atherosclerosis includes some consecutive stages beginning with free-radical activation in arterial tissues and blood. The free radical and their reactive species involves physico-chemical changes in plasmatic membranes and lipoproteins, damages of genome, cytotoxicity (apoptosis or reproductive death) and opposite effect of cytoprotection. The activation of intrinsic recovery/repair mechanisms after above types of injury has been associated with the induction of changes in amount of B,E- receptors and lipoproteins modification, the increase of the complexes lipoprotein-antibody. The subsequent events demonstrate the development of dyslipoproteinemias, the functional and morphological injures, appearance of "foam cells" and atherosclerotic damages of arterial wall.
Chaialo
P P
PP
Research Centre for Radiation Medicine, Academy of Medicol Science of Ukraine, Kiev.
Pliushch
G I
GI
D000818:Animals; D017209:Apoptosis; D001158:Arteries / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology* / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D004249:DNA Damage; D005487:Foam Cells / Q000473:pathology / Q000502:physiology; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D011839:Radiation, Ionizing
D005609:Free Radicals; D008074:Lipoproteins