The Y chromosome and its role in testis differentiation and spermatogenesis.
The Y chromosome contains genes and gene families that play critical roles in the processes of testis determination and testis differentiation. Great strides have been made toward defining the genetic pathways associated with the determination of gender. The data are summarized and discussed and clinical ramifications are considered.
Kent-First
M
M
Department of Obstetrics & Gynecology, University of Wisconsin and Promega Corp., Madison, Wisconsin, USA.
D002454:Cell Differentiation; D017353:Gene Deletion; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D009154:Mutation; D009845:Oligospermia / Q000235:genetics; D012729:Sex Chromosome Aberrations; D019849:Sex Determination Processes; D012733:Sex Differentiation / Q000235:genetics*; D013091:Spermatogenesis / Q000235:genetics*; D013737:Testis / Q000196:embryology*; D014998:Y Chromosome