[Changes of T lymphocyte and CD4+ T helper subsets in peripheral blood from women with unexplained recurrent spontaneous abortion].
OBJECTIVE
To investigate the relationship between occurrence of unexplained recurrent spontaneous abortion(URSA) and immune function of T lymphocytes.


METHODS
T lymphocyte subsets and CD4+ T helper subsets (including T helper 1 and T helper 2 cells) in peripheral blood from 30 cases with URSA and 24 healthy women (controls) were detected by enzyme-linked immunospot assay (ELISPOT).


RESULTS
The percentage of CD4+ positive T lymphocytes in URSA group was higher than that in the controls (60% vs 45%, P < 0.05). Compared with the normal group, the percentage of Th1 cells increased (26% vs 14%, P < 0.01) but the percentage of Th2 cells decreased (7% vs 20%, P < 0.05), the ratio of Th1 to Th2 increased (3.80 vs 0.73, P < 0.01) in the URSA group.


CONCLUSIONS
The occurrence of URSA might be associated with proliferation of the CD4+ positive T cells and enhancement of cellular immune function mediated by Th1 cells.
Mao
L
L
Department of Immunology, Tainjin Medical University, Tianjin 300070, China.
Yang
P
P
Yan
Y
Y
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D011247:Pregnancy; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology