Human immunodeficiency virus type 1-specific immunity after genetic immunization is enhanced by modification of Gag and Pol expression.
Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial Pol responses. This fusion protein may be useful for AIDS vaccines.
Huang
Y
Y
Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Kong
W P
WP
Nabel
G J
GJ
D016915:AIDS Vaccines / Q000276:immunology*; D000818:Animals; D019677:Artificial Gene Fusion; D002461:Cell Line, Transformed; D005260:Female; D015750:Genes, gag / Q000276:immunology*; D015751:Genes, pol / Q000276:immunology*; D015483:HIV Antibodies / Q000097:blood; D016655:HIV Core Protein p24 / Q000276:immunology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D051379:Mice; D008807:Mice, Inbred BALB C; D014611:Vaccination; D019444:Vaccines, DNA / Q000276:immunology*
D016915:AIDS Vaccines; D015483:HIV Antibodies; D016655:HIV Core Protein p24; D019444:Vaccines, DNA