The relation of urinary Tamm-Horsfall-protein on CaOx-crystallization under the scope of the Bonn-Risk-Index.
In previous papers we introduced the Bonn-Risk Index (BRI) as a new method of evaluating an individual's actual risk of forming calcium oxalate (CaOx). A comparison of our results with the calculated urinary relative supersaturations (RS) with respect to CaOx, showed that samples with similar values of RS can have different values of BRI. We suggested that this may reflect the individual influence of the urinary macromolecular constituents which are not taken into account at the calculation of RS. To estimate the role of macromolecules on the value of BRI, we examined 45 unprepared 24-h urine samples from 24 persons (16 healthy subjects, eight CaOx stone-formers) with respect to BRI, RS, and the concentration of urinary Tamm-Horsfall-protein ([THP]). The crystallization experiments were carried out by the use of a laser-probe. Based on the data of BRI and RS, the effect of THP may shift from a minor promoter in stone-formers and persons "at risk", to an inert urinary constituent in healthy subjects and persons "without risk". However, the observed effects are small and at least in the latter group close to zero.
Laube
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N
Division of Experimental Urology, Department of Urology, Bonn University, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. laube@mailer.meb.uni-bonn.de
Glatz
S
S
Hesse
A
A
D000328:Adult; D000368:Aged; D002129:Calcium Oxalate / Q000737:chemistry* / Q000652:urine; D003460:Crystallization; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000175:diagnosis / Q000453:epidemiology / Q000652:urine*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009088:Mucoproteins / Q000737:chemistry* / Q000652:urine; D011237:Predictive Value of Tests; D012307:Risk Factors; D058949:Uromodulin
D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin; D002129:Calcium Oxalate