Cloning and developmental expression of a zebrafish meis2 homeobox gene.
We show here that a zebrafish meis2 gene homolog has a dynamic expression pattern in the developing mesoderm and central nervous system. Meis family homeodomain proteins are known to act as cofactors with other homeodomain proteins. We find expression of meis2.1 in the developing zebrafish hindbrain and somites, correlating with reported sites of zebrafish hox gene expression, as well as in presumptive cerebellum, midbrain, retina and ventral forebrain. The expression pattern shares some, but not all, features with that of murine Meis2.
Zerucha
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University of Chicago Committee for Cancer Biology, Chicago, IL 60637, USA.
Prince
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D000595:Amino Acid Sequence; D000818:Animals; D001921:Brain / Q000196:embryology; D002490:Central Nervous System / Q000378:metabolism; D018076:DNA, Complementary / Q000378:metabolism; D018398:Homeodomain Proteins / Q000096:biosynthesis* / Q000235:genetics*; D017403:In Situ Hybridization; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D010802:Phylogeny; D020033:Protein Isoforms; D012160:Retina / Q000196:embryology; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014018:Tissue Distribution; D015027:Zebrafish; D029961:Zebrafish Proteins
D018076:DNA, Complementary; D018398:Homeodomain Proteins; C102641:Mrg1 protein, mouse; D020033:Protein Isoforms; D029961:Zebrafish Proteins; C491173:meis2b protein, zebrafish