title: Effects of curved inlet tubes on air flow and particle deposition in bifurcating lung models.
abstract: In vivo bifurcating airways are complex and the airway segments leading to the bifurcations are not always straight, but curved to various degrees. How do such curved inlet tubes influence the motion as well as local deposition and hence the biological responses of inhaled particulate matter in lung airways? In this paper steady laminar dilute suspension flows of micron-particles are simulated in realistic double bifurcations with curved inlet tubes, i.e., 0 degrees < or =theta< or =90 degrees, using a commercial finite-volume code with user-enhanced programs. The resulting air-flow patterns as well as particle transport and wall depositions were analyzed for different flow inlet conditions, i.e., uniform and parabolic velocity profiles, and geometric configurations. The curved inlet segments have quite pronounced effects on air-flow, particle motion and wall deposition in the downstream bifurcating airways. In contrast to straight double bifurcations, those with bent parent tubes also exhibit irregular variations in particle deposition efficiencies as a function of Stokes number and Reynolds number. There are fewer particles deposited at mildly curved inlet segments, but the particle deposition efficiencies at the downstream sequential bifurcations vary much when compared to those with straight inlets. Under certain flow conditions in sharply curved lung airways, relatively high, localized particle depositions may take place. The findings provide necessary information for toxicologic or therapeutic impact assessments and for global lung dosimetry models of inhaled particulate matter.
authors: Center for Environmental Medicine and Lung Biology, University of North Carolina, Chapel Hill, NC 27599, USA.
authors: Z
authors: Z
authors: Zhang
authors: C
authors: C
authors: Kleinstreuer
authors: C S
authors: CS
authors: Kim
mesh_terms: D001696:Biomechanical Phenomena; D006801:Humans; D008168:Lung / Q000033:anatomy & histology* / Q000502:physiology*; D008953:Models, Anatomic; D008954:Models, Biological; D015656:Respiratory Mechanics