Introduction of tissue engineering concepts into the field of endovascular grafts: an attempt to solve endoleakage problems of endovascular grafts implanted in aortic aneurysms.
To solve endoleakage problems of endovascular prostheses inserted in aortic aneurysms, a concept originating from tissue engineering was proposed. We proposed that in order to accelerate the thrombus inside the aneurysm, three major factors for successful tissue engineering, i.e., appropriate cells, extracellular matrices, and growth factors, should be introduced into a space between the endovascular grafts and the aneurysm. As a simulation model in animals, two kinds of fabric vascular prostheses were used. One was a small graft used as an endovascular graft and another was a large graft as an envelope for the small graft, used as the aneurysm wall. Adipose tissue fragments with fresh blood coagula were injected between the two grafts. The control was a preparation without tissue fragments. Two months and a half after surgery, the test group showed complete connective tissue formation in the space between the two grafts, but in the control, brownish thrombus remained. From this experiment, we speculated that tissue fragment transplantation will accelerate connective tissue formation of the thrombus, and this complete organization of the thrombus might reduce endoleakage.
Noishiki
Y
Y
Department of Surgery, Yokohama City University, School of Medicine, Yokohama, Japan.
Ichikawa
Y
Y
Kosuge
T
T
Yamazaki
I
I
Yamamoto
K
K
Manabe
T
T
Lu
Y
Y
Yamane
Y
Y
D000273:Adipose Tissue / Q000637:transplantation*; D000818:Animals; D001014:Aortic Aneurysm / Q000601:surgery*; D001698:Biomedical Engineering; D001807:Blood Vessel Prosthesis / Q000009:adverse effects; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D004285:Dogs; D005260:Female; D015607:Stents / Q000009:adverse effects; D013927:Thrombosis