title: Discovery and optimization of a novel series of thrombin receptor (par-1) antagonists: potent, selective peptide mimetics based on indole and indazole templates.
authors: The R. W. Johnson Pharmaceutical Research Institute, Spring House, Pennsylvania 19477, USA. hzhang@prius.jnj.com
authors: H C
authors: HC
authors: Zhang
authors: C K
authors: CK
authors: Derian
authors: P
authors: P
authors: Andrade-Gordon
authors: W J
authors: WJ
authors: Hoekstra
authors: D F
authors: DF
authors: McComsey
authors: K B
authors: KB
authors: White
authors: B L
authors: BL
authors: Poulter
authors: M F
authors: MF
authors: Addo
authors: W M
authors: WM
authors: Cheung
authors: B P
authors: BP
authors: Damiano
authors: D
authors: D
authors: Oksenberg
authors: E E
authors: EE
authors: Reynolds
authors: A
authors: A
authors: Pandey
authors: R M
authors: RM
authors: Scarborough
authors: B E
authors: BE
authors: Maryanoff
mesh_terms: D000800:Angioplasty, Balloon; D000818:Animals; D003251:Constriction, Pathologic; D005343:Fibrinolytic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D006168:Guinea Pigs; D007191:Indazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018716:Molecular Mimicry; D009130:Muscle, Smooth / Q000187:drug effects / Q000473:pathology; D051381:Rats; D044463:Receptor, PAR-1; D018179:Receptors, Thrombin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D005343:Fibrinolytic Agents; D007191:Indazoles; D007211:Indoles; C424723:RWJ 58259; D044463:Receptor, PAR-1; D018179:Receptors, Thrombin; D014508:Urea