title: Molecular and genomic analysis of genes encoding surface-anchored proteins from Clostridium difficile.
abstract: The gene slpA, encoding the S-layer precursor protein in the virulent Clostridium difficile strains C253 and 79--685, was identified. The precursor protein carries a C-terminal highly conserved anchoring domain, similar to the one found in the Cwp66 adhesin (previously characterized in strain 79--685), an SLH domain, and a variable N-terminal domain mediating cell adherence. The genes encoding the S-layer precursor proteins and the Cwp66 adhesin are present in a genetic locus carrying 17 open reading frames, 11 of which encode a similar two-domain architecture, likely to include surface-anchored proteins.
authors: Département de Microbiologie, Faculté de Pharmacie, Université de Paris-Sud, 92296 Châtenay-Malabry Cedex, France.
authors: T
authors: T
authors: Karjalainen
authors: A J
authors: AJ
authors: Waligora-Dupriet
authors: M
authors: M
authors: Cerquetti
authors: P
authors: P
authors: Spigaglia
authors: A
authors: A
authors: Maggioni
authors: P
authors: P
authors: Mauri
authors: P
authors: P
authors: Mastrantonio
mesh_terms: D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics*; D016360:Clostridioides difficile / Q000737:chemistry / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D016366:Open Reading Frames; D017385:Sequence Homology
chemical_list: D001426:Bacterial Proteins; C070683:surface layer protein A, Bacteria