Skin and nail changes in children with sickle cell anemia receiving hydroxyurea therapy.
Skin and nail changes from long-term hydroxyurea therapy are reported in adults. Skin and nail changes, including nail hyperpigmentation, longitudinal bands, and hyperpigmentation of the palms and other skin surfaces, developed in 7 children with sickle cell anemia after 6 to 16 weeks of hydroxyurea therapy. Cutaneous and nail changes may occur in children receiving hydroxyurea.
O'branski
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Duke University Pediatric Sickle Cell Program and Division of Hematology/Oncology, Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA.
Ware
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Prose
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Kinney
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D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D000986:Antisickling Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D017495:Hyperpigmentation / Q000209:etiology* / Q000473:pathology; D008297:Male; D009260:Nail Diseases / Q000209:etiology* / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology*
D000986:Antisickling Agents; D006918:Hydroxyurea