The genomic structure of SYCP3, a meiosis-specific gene encoding a protein of the chromosome core.
SYCP3 localizes to the lateral elements of the synaptonemal complex and is essential for male meiosis. The genomic structure of SYCP3 consists of nine exons spanning approximately 14 kb. In mouse and rat, but not in hamster, the putative translation start of SYCP3 is present in the first exon. The putative promoter of SYCP3 was also cloned and shown to drive transcription of a reporter gene in somatic cells.
Botelho
R J
RJ
Department of Biology, York University, 4700 Keele St., Toronto, Ont., Canada M3J 1P3.
DiNicolo
L
L
Tsao
N
N
Karaiskakis
A
A
Tarsounas
M
M
Moens
P B
PB
Pearlman
R E
RE
D016475:3T3 Cells; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D005091:Exons; D007438:Introns; D008540:Meiosis / Q000235:genetics; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics*; D011401:Promoter Regions, Genetic; D013573:Synaptonemal Complex / Q000737:chemistry / Q000235:genetics*; D014162:Transfection
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C489754:Sycp1 protein, mouse; C490062:Sycp3 protein, mouse