IL-5-induced airway eosinophilia--the key to asthma?
Bronchial asthma is a chronic inflammatory airway disease defined by reversible airway obstruction and non-specific airway hyper-responsiveness (AHR). Although profound insights have been made into the pathophysiology of asthma, the exact mechanisms inducing and regulating the disease are still not fully understood. Yet, it is generally accepted that the pathological changes in asthma are induced by a chronic inflammatory process which is characterized by infiltration of the bronchial mucosa with lymphocytes and eosinophils, increased mucus production and submucosal edema. There is increasing evidence that an imbalance in the T-helper (Th) cell response of genetically predisposed individuals to common environmental antigens plays a pivotal role in the pathogenesis of allergic bronchial asthma and other atopic disorders. Following allergic sensitization, T cells from atopic patients tend to produce elevated levels of Th2-type cytokines, especially interleukin (IL)-4, IL-13, IL-5 and IL-6, which induce and regulate IgE production and eosinophil airway infiltration. In this review, the role of Th2-type cytokines, IgE and airway eosinophils in the induction of airway inflammation and AHR is discussed, and animal studies of asthma and AHR, mainly in rodents will be considered. A better understanding of the underlying mechanisms leading to asthma pathology may yield more specific immunological strategies for the treatment of this disease which is increasing worldwide.
Hamelmann
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Department of Pediatrics, University Hospital Charite, Berlin, Germany. eckard.hamelmann@charite.de
Gelfand
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EW
D000818:Animals; D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D001982:Bronchial Diseases / Q000276:immunology / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000276:immunology / Q000503:physiopathology; D004802:Eosinophilia / Q000276:immunology / Q000503:physiopathology*; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology / Q000503:physiopathology; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology; D007249:Inflammation; D015847:Interleukin-4 / Q000502:physiology; D015848:Interleukin-5 / Q000502:physiology*; D008407:Mast Cells / Q000276:immunology / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008819:Mice, Nude; D023421:Models, Animal; D018448:Models, Immunological; D009092:Mucous Membrane / Q000276:immunology / Q000473:pathology; D018418:Th2 Cells / Q000276:immunology / Q000378:metabolism
D015848:Interleukin-5; D015847:Interleukin-4; D007073:Immunoglobulin E