A possible role for lamivudine as prophylaxis against hepatitis B reactivation in carriers of hepatitis B who undergo chemotherapy and autologous peripheral blood stem cell transplantation for non-Hodgkin's lymphoma.
Hepatitis B virus (HBV) reactivation, a well-known complication in immunosuppressed patients, can give rise to acute hepatitis and even fatal fulminant hepatitis. Three Japanese males with non-Hodgkin's lymphoma (NHL) who were carriers of HBV received high-dose chemotherapy followed by autologous peripheral blood stem cell transplantation (PBSCT). To prevent HBV reactivation, all received oral lamivudine (150 mg/day), a nucleoside analogue, at the start of chemotherapy. All were treated at full-dose intensity, including corticosteroids, without modification of treatment regimens. All three patients completed the total course of chemotherapy and PBSCT, with no signs of HBV reactivation. Peripheral blood stem cell (PBSC) harvests and hematological recoveries after transplantation were not affected by lamivudine, which was continued for at least 16 weeks after transplantation. HBV-DNA and DNA polymerase levels remained negative/normal after discontinuation of lamivudine. Lamivudine effectively inhibits HBV replication and has few serious adverse effects, particularly those related to hematopoiesis. Thus, prophylactic use of lamivudine from initiation of chemotherapy deserves consideration in the treatment of HBV carriers who require immunosuppressive chemotherapy, and may prevent HBV reactivation.
Endo
T
T
Department of Internal Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
Sakai
T
T
Fujimoto
K
K
Yamamoto
S
S
Takashima
H
H
Haseyama
Y
Y
Nishio
M
M
Koizumi
K
K
Koike
T
T
Sawada
K
K
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D004279:DNA, Viral / Q000097:blood; D004359:Drug Therapy, Combination; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006509:Hepatitis B / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D006515:Hepatitis B virus / Q000187:drug effects / Q000235:genetics; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000628:therapy* / Q000821:virology; D008297:Male; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage; D014182:Transplantation, Autologous / Q000379:methods; D014775:Virus Activation / Q000187:drug effects
D000970:Antineoplastic Agents; D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine