title: Short-term effect of mitomycin-C augmented trabeculectomy on axial length and corneal astigmatism.
abstract: OBJECTIVE
  To evaluate the short-term effect of trabeculectomy with adjunctive mitomycin-C (MMC) on corneal astigmatism and axial length.
  
  
  METHODS
  Asan Medical Center, University of Ulsan, Department of Ophthalmology, Seoul, Korea.
  
  
  METHODS
  Eighteen consecutive eyes of 16 patients having trabeculectomy with adjunctive MMC were prospectively analyzed. Intraocular pressure (IOP) and axial length were evaluated preoperatively and 1, 3, 6, and 12 months postoperatively. Postoperative changes in corneal astigmatism were evaluated using vector analysis.
  
  
  RESULTS
  The overall mean induced astigmatism showed with-the-rule change up to 3 months postoperatively followed by an against-the-rule shift. The mean axial length was significantly less postoperatively and changed throughout the 12 month follow-up. There was a positive correlation between postoperative axial length and IOP. Eyes with higher preoperative IOP had a greater decrease in axial length after trabeculectomy with MMC.
  
  
  CONCLUSIONS
  The induced corneal astigmatism after trabeculectomy with MMC was long lasting, although less than that in previous studies. The change in axial length after surgery was significant, especially in eyes with a high preoperative IOP. The decrease in axial length persisted throughout the follow-up.
authors: Department of Ophthalmology, Ulsan University School of Medicine, Asan Medical Center, Seoul, South Korea.
authors: M S
authors: MS
authors: Kook
authors: H B
authors: HB
authors: Kim
authors: S U
authors: SU
authors: Lee
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000886:Anthropometry; D001251:Astigmatism / Q000175:diagnosis / Q000209:etiology*; D017024:Chemotherapy, Adjuvant; D003315:Cornea / Q000473:pathology*; D005123:Eye / Q000473:pathology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D011446:Prospective Studies; D014130:Trabeculectomy / Q000009:adverse effects*
chemical_list: D016685:Mitomycin