Gastrointestinal stromal tumour of the rectum.
Gastrointestinal stromal tumour (GIST) has been immunohistochemically defined as the tumour lacking differentiation towards either leiomyomatous tumour or schwannoma. We report a 75-year-old man who underwent an abdominoperineal resection of a large submucosal tumour of the rectum. The excised specimen was revealed to be an elastic soft tumour, 8 x 7 x 6 cm in size, which histologically consisted of spindle-shaped cells without nuclear atypia. The mitotic count was fewer than 2 per 10 high-power fields. The tumour cells were positive for staining of CD34 and c-kit protein, while the lesions were negative for alpha-smooth muscle actin, HHF-35, neuron-specific enolase, and S-100 protein. The diagnosis of GIST was confirmed by immunohistochemical examination of the tumour. From these findings, the present case is thought to be potentially malignant, and a long-term follow-up observation is needed for the case.
Shibata
Y
Y
Department of Surgery, Hokushu Central Hospital, Takanosu, Akita, Japan. CQE03022@nifty.ne.jp
Ueda
T
T
Seki
H
H
Yagihashi
N
N
D000368:Aged; D018952:Antigens, CD34 / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008648:Mesoderm; D019009:Proto-Oncogene Proteins c-kit / Q000378:metabolism; D012004:Rectal Neoplasms / Q000378:metabolism / Q000473:pathology*
D018952:Antigens, CD34; D019009:Proto-Oncogene Proteins c-kit