Toward tissue engineering of the knee meniscus.
This review details current efforts to tissue engineer the knee meniscus successfully. The meniscus is a fibrocartilaginous tissue found within the knee joint that is responsible for shock absorption, load transmission, and stability within the knee joint. If this tissue is damaged, either through tears or degenerative processes, then deterioration of the articular cartilage can occur. Unfortunately, there is a dearth in the amount of work done to tissue engineer the meniscus when compared to other musculoskeletal tissues, such as bone. This review gives a brief overview of meniscal anatomy, biochemical properties, biomechanical properties, and wound repair techniques. The discussion centers primarily on the different components of attempting to tissue engineer the meniscus, such as scaffold materials, growth factors, animal models, and culturing conditions. Our approach for tissue engineering the meniscus is also discussed.
Sweigart
M A
MA
Department of Bioengineering, Rice University, Houston, Texas 77251, USA.
Athanasiou
K A
KA
D000818:Animals; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering / Q000379:methods*; D007718:Knee Injuries / Q000473:pathology / Q000601:surgery*; D008592:Menisci, Tibial / Q000033:anatomy & histology / Q000737:chemistry / Q000601:surgery* / Q000637:transplantation; D000070600:Tibial Meniscus Injuries; D014945:Wound Healing