title: Influence of low proximal aortic pressure on spinal cord oxygenation in experimental thoracic aortic occlusion.
abstract: BACKGROUND
  To evaluate the effect of low proximal aortic pressure on cerebrospinal fluid (CSF) oxygenation in an experimental thoracic occlusion model.
  
  
  METHODS
  In nine pigs, continuous intrathecal pO(2), pCO(2) and pH monitoring was used during double descending thoracic aortic clamping following insertion of an aorto-aortic shunt. In five pigs, the shunt was connected to a citrated bag adjusted at approximately 40-45 cm above the heart for partial exsanguination in order to decrease mean proximal aortic pressure (MPAP) to below 50 mmHg. In four animals, sodium nitroprusside infusion was used for this purpose.
  
  
  RESULTS
  Intrathecal pO(2) demonstrated a significant decrease from 4.9+/-2.1 to 2.9+/-2.4 kPa after 10 minutes of aortic cross-clamping. Lowering proximal aortic pressure caused a further significant decrease to 1.2+/-1.7 kPa (p<0.05). In seven pigs (5 in the exsanguination and 2 in the vasodilator group), restoration of mean proximal aortic pressure to 94.0+/-27.7 caused a recovery of CSF pO(2) from 1.2+/-1.9 to 2.8+/-3.0 (p<0.05).
  
  
  CONCLUSIONS
  The results of this study demonstrate that MPAP which provides spinal cord perfusion through subclavian-vertebral arteries are crucial for maintenance of spinal cord oxygenation during thoracic aortic occlusion in this pig model.
authors: Department of Surgery, University Hospital, Uppsala, Sweden.
authors: A
authors: A
authors: Hellberg
authors: A
authors: A
authors: Tulga Ulus
authors: L
authors: L
authors: Christiansson
authors: D
authors: D
authors: Bergqvist
authors: S
authors: S
authors: Thelin
authors: S
authors: S
authors: Karacagil
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D001794:Blood Pressure; D003250:Constriction; D005260:Female; D008297:Male; D010100:Oxygen / Q000134:cerebrospinal fluid*; D020760:Spinal Cord Ischemia / Q000503:physiopathology*; D013552:Swine
chemical_list: D010100:Oxygen