A facile synthesis of 3-substituted-2-aminothiophenes and 1,3-disubstituted-2-methylthiopyrroles.
Electron-rich 3-functionalized-2-aminothiophenes 6 and 1,3-disubstituted-2-methylthiopyrroles 10 were synthesized from substituted allyl benzotriazoles 2 and isothiocyanates 3 via condensation and subsequent heterocyclization.
Katritzky
A R
AR
Center for Heterocyclic Compounds, Department of Chemistry, University of Florida, Gainesville, FL 32611-7200, USA. Katritzky@chem.ufl.edu
Wang
X
X
Denisenko
A
A