The contribution of mesangial cell proliferation to progressive glomerular injury.
Mesangial cell proliferation is a general characteristic of a variety of glomerular diseases. Therefore, an understanding of the regulatory mechanism is important for treatment of glomerular diseases. The present review shows that the growth arrest gene 6 (Gas 6) is a new autocrine growth factor of mesangial cells and that warfarin inhibits mesangial cell proliferation by inhibiting the gamma-carboxylation of Gas 6 in vitro and in vivo. The present findings also show that a vitamin D analog (22-oxa-calcitriol) is a new growth regulator of mesangial cells in vitro and in vivo. These findings indicate that these compounds have considerable potential for therapeutic use in the treatment of progressive glomerular disease.
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Department of Laboratory Medicine, University of Tokushima School of Medicine, Tokushima, Japan.
D000818:Animals; D002455:Cell Division; D018450:Disease Progression; D005920:Glomerular Mesangium / Q000166:cytology* / Q000293:injuries* / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins / Q000378:metabolism / Q000502:physiology; D014807:Vitamin D / Q000031:analogs & derivatives; D000099255:Growth Arrest-Specific Protein 6
D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D014807:Vitamin D; D000099255:Growth Arrest-Specific Protein 6