Structured treatment interruptions to control HIV-1 and limit drug exposure.
Although therapy-mediated suppression of HIV-1 is effective and results in a degree of immune reconstitution, the complications resulting from life-long treatment emphasize the need for alternatives. This review discusses the use of structured interruptions in antiviral therapy to induce drug-free periods of immune-mediated control of HIV-1. Such an approach has the ultimate objective of harnessing anti-viral immune responses, reducing drug exposure (toxicity and cost) and potentially extending the clinical benefits of a suppressive treatment regimen.
Montaner
L J
LJ
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA. Montaner@wistar.upenn.edu
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000276:immunology; D000208:Acute Disease; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D002908:Chronic Disease; D004334:Drug Administration Schedule; D015497:HIV-1 / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D012307:Risk Factors
D019380:Anti-HIV Agents; D007166:Immunosuppressive Agents