In vivo measurement of [11C]verapamil kinetics in human tissues.
OBJECTIVE
To evaluate [11C]verapamil kinetics in humans.


METHODS
After intravenous injection of [11C]verapamil (370 MBq, specific activity >1,600 GBq/mmol), kinetics were evaluated in five cancer patients using positron emission tomography (PET).


RESULTS
One hour after injection, accumulation of [11C] in lungs, heart and tumour was 43.0%, 1.3% and 0.9% of the injected verapamil dose, respectively. Half-lives of [11C]verapamil in these tissues were 46.2 min, 73.8 min and 23.7 min, respectively.


CONCLUSIONS
Intravenously administered [11C] was mainly extracted by the lungs. Transport of a [11C]verapamil bolus out of solid tumour tissue is relatively fast.
Hendrikse
N H
NH
PET Center, Groningen University Hospital, The Netherlands. n.h.hendrikse@pet.azg.nl
de Vries
E G
EG
Franssen
E J
EJ
Vaalburg
W
W
van der Graaf
W T
WT
D000328:Adult; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000378:metabolism*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed; D014700:Verapamil / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D002121:Calcium Channel Blockers; D014700:Verapamil