Effect of the calcium channel blockers nifedipine and diltiazem on pentylenetetrazole kindling-provoked amnesia in rats.
A large body of research supports the view that memory disturbance is an integral part of epilepsy. Deficit in various behaviour tasks has been found in rats subjected to experimental epilepsy-pentylenetetrazole (PTZ) kindling. In the present study we examined the effect of post-training administered calcium channel blockers nifedipine (10 and 40 mg/kg) and diltiazem (10 and 30 mg/kg) on amnesia induced by PTZ kindling in shuttle-box- and step-down-trained rats. Retention in nifedipine- or diltiazem-treated kindled animals was significantly improved compared to the kindled controls. The mechanisms of action of calcium antagonists studied is considered. Taken together with the data about calcium channel blocker anticonvulsive activity, the results of this study further suggest that nifedipine and diltiazem might be useful in the treatment of cognitive disorders in epileptic patients.
Genkova-Papazova
M G
MG
Laboratory of CNS Pharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Acad. G. Bonchev Str., Bl. 23, 1113, Sofia, Bulgaria. books@iph.bio.bas.bg
Petkova
B
B
Shishkova
N
N
Lazarova-Bakarova
M
M
D000647:Amnesia / Q000139:chemically induced / Q000523:psychology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D002121:Calcium Channel Blockers; D003292:Convulsants; D004110:Diltiazem; D009543:Nifedipine; D010433:Pentylenetetrazole