title: Divergent and convergent evolution of NK-cell receptors.
abstract: Natural killer (NK)-cell receptors specific for major histocompatibility complex (MHC) class I molecules have been identified in humans and mice. Some of the most important receptors are structurally unrelated in the two species: the murine Ly-49 receptors are C-type lectins, while human killer-cell inhibitory receptors (KIRs) belong to the immunoglobulin superfamily. Here, Roland Barten and colleagues describe the divergent and convergent evolution of NK-cell receptors.
authors: Immunology Division, Dept of Pathology, University of Cambridge, UK.
authors: R
authors: R
authors: Barten
authors: M
authors: M
authors: Torkar
authors: A
authors: A
authors: Haude
authors: J
authors: J
authors: Trowsdale
authors: M J
authors: MJ
authors: Wilson
mesh_terms: D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D007694:Killer Cells, Natural / Q000737:chemistry / Q000276:immunology / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D054340:Receptors, KIR; D016176:T-Lymphocyte Subsets / Q000737:chemistry* / Q000276:immunology
chemical_list: D011971:Receptors, Immunologic; D054340:Receptors, KIR