The first synthesis of enantiopure alpha-amino ketimines and amino aziridines.
Chiral 1-aminoalkyl chloromethyl ketimines 2 are synthesized in enantiomerically pure form starting from 1-aminoalkyl chloromethyl ketones 1 and different amines. Reduction of amino ketimines 2 and subsequent spontaneous cyclization affords aminoalkyl aziridines 3 with high diastereoisomeric excess and without detectable racemization.
Concellón
J M
JM
Departamento de Química Física y Analítica, Facultad de Química, Universidad de Oviedo, Julián Clavería 8, 33071 Oviedo, Spain. jmcg@sauron.quimica.uniovi.es
Bernad
P L
PL
Riego
E
E
García-Granda
S
S
Forcén-Acebal
A
A