Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component.
Many diseases associated with ageing have an underlying oxidative stress and accompanying inflammatory component, for example, Alzheimer's disease or atherosclerosis. Reviewed in this manuscript are: the role of oxidative stress in activating the transcription factor nuclear factor kappa B (NFkappaB), the role of NFkappaB in activating proinflammatory gene transcription, strong oxidants produced by cells, anti-oxidant defense systems, the central role of phase 2 enzymes in the anti-oxidant defense, dietary phase 2 enzyme inducers and evidence that dietary phase 2 enzymes decrease oxidative stress. It is likely that a diet containing phase 2 enzyme inducers may ameliorate or even prevent diseases that have a prominent inflammatory component to them. Research should be directed into the potential therapeutic effects of dietary phase 2 enzyme inducers in ameliorating diseases with an underlying oxidative stress and inflammatory component to them.
Juurlink
B H
BH
Department of Anatomy & Cell Biology, The Cameco Multiple Sclerosis and Neuroscience Research Centre, College of Medicine, University of Saskatchewan, Saskatoon, Canada. juurlink@duke.usask.ca
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D004790:Enzyme Induction / Q000502:physiology*; D005504:Food Analysis; D006801:Humans; D007249:Inflammation / Q000178:diet therapy* / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology
D000975:Antioxidants; D016328:NF-kappa B