Atropisomeric derivatives of 2',6'-disubstituted (R)-11-phenylaporphine: selective serotonin 5-HT(7) receptor antagonists.
Linnanen
T
T
Organic Pharmaceutical Chemistry, Uppsala University, Uppsala Biomedical Centre, Box 574, SE-751 23 Uppsala, Sweden.
Brisander
M
M
Unelius
L
L
Rosqvist
S
S
Nordvall
G
G
Hacksell
U
U
Johansson
A M
AM
D000818:Animals; D001060:Aporphines / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism; D016466:CHO Cells; D006224:Cricetinae; D018360:Crystallography, X-Ray; D000242:Cyclic AMP / Q000096:biosynthesis; D066298:In Vitro Techniques; D008968:Molecular Conformation; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001060:Aporphines; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C104425:serotonin 7 receptor; D000242:Cyclic AMP