Transcription program of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus).
Human herpesvirus 8 (HHV-8), a gammaherpesvirus implicated in Kaposi's sarcoma, primary effusion lymphoma, and Castleman's disease, encodes several pathogenically important cellular homologs. To define the HHV-8 transcription program, RNA obtained from latently infected body cavity-based lymphoma 1 cells induced to undergo lytic replication was used to query a custom HHV-8 DNA microarray containing nearly every known viral open reading frame. The patterns of viral gene expression offer insights into the replication and pathogenic strategies of HHV-8.
Paulose-Murphy
M
M
HIV and AIDS Malignancy Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA.
Ha
N K
NK
Xiang
C
C
Chen
Y
Y
Gillim
L
L
Yarchoan
R
R
Meltzer
P
P
Bittner
M
M
Trent
J
J
Zeichner
S
S
D002460:Cell Line; D020869:Gene Expression Profiling; D015967:Gene Expression Regulation, Viral; D016679:Genome, Viral; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D014158:Transcription, Genetic