title: Impact of enteral feeding on gastric tonometry in healthy volunteers and critically ill patients.
abstract: BACKGROUND
  Enteral feeding may interfere with gastric tonometry measurement. The effect of enteral nutrition on gastric tonometry has not been fully documented.
  
  
  METHODS
  Seven healthy volunteers and nine stable intensive care unit (ICU) patients with poor tolerance of gastric feeding were investigated. Consecutive continuous postpyloric and gastric feeding, both at two different rates (40 and 100 ml. h-1, respectively), and an intragastric 200 ml nutrition bolus were studied. Gastric intramucosal PCO2 (PiCO2) was measured by air tonometry and in patients a gastric intramucosal-arterial PCO2 difference (PCO2 gap) was calculated. Hemodynamics and blood gases were also measured.
  
  
  RESULTS
  In volunteers, PiCO2 remained stable during the postpyloric phase. During continuous gastric feeding PiCO2 did not change significantly, although in 4 volunteers PiCO2 increased >0.5 kPa. PiCO2 decreased significantly after gastric bolus from 6.9+/-0.4 to 6.1+/-0.5 kPa (P<0.05). Eight patients had an increased PCO2 gap (>1 kPa) at baseline (1.8+/-0.6 kPa). PCO2 gap changes during the whole study were not statistically significant. However, during the postpyloric phase (or immediately afterwards), the PCO2 gap increased by more than 0.5 kPa in 5 patients. After gastric bolus, a decrease in PCO2 gap >0.5 kPa was seen in 5 patients.
  
  
  CONCLUSIONS
  In volunteers, postpyloric feeding does not interfere with gastric tonometry measurement and gastric bolus leads to a PiCO2 decrease. The impact of postpyloric and gastric feeding on gastric tonometry in ICU patients with compromised gut is variable.
authors: Intensive Care Unit, Medical Department I, Charles University Hospital Plzen, Alej Svobody 80, 304 60 Plzen, Czech Republic. rokyta@fnplzen.cz
authors: R
authors: R
authors: Rokyta
authors: I
authors: I
authors: Novák
authors: M
authors: M
authors: Matĕjovic
authors: P
authors: P
authors: Hora
authors: M
authors: M
authors: Nalos
authors: V
authors: V
authors: Srámek
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000032:analysis; D003422:Critical Care; D004750:Enteral Nutrition / Q000009:adverse effects*; D005260:Female; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011708:Pylorus / Q000502:physiology; D013270:Stomach / Q000502:physiology*
chemical_list: D002245:Carbon Dioxide