Tetrachlorodecaoxide does not jeopardize anastomotic healing: an experimental study in animals.
Tetrachlorodecaoxide (TCDO) is a negatively-charged complex of chlorine and oxygen commonly used for the treatment of infected external wounds. However, it displays antiadhesive properties when applied intra-abdominally. In rats, small-bowel and a large-bowel anastomoses were performed and one-half of the animals received TCDO. It was found that TCDO did not alter the bursting pressures of small and large-bowel anastomoses at 1, 3 and 9 days postoperatively.
Schier
F
F
Department of Pediatric Surgery, University Medical Center Jena, Bachstrasse 18, 07740 Jena, Germany.
Bondartschuk
M
M
Danzer
E
E
D000714:Anastomosis, Surgical; D000818:Animals; D001696:Biomechanical Phenomena; D002713:Chlorine / Q000494:pharmacology*; D007421:Intestine, Small / Q000473:pathology / Q000601:surgery*; D008297:Male; D010087:Oxides / Q000494:pharmacology*; D051381:Rats; D013529:Surgical Wound Dehiscence / Q000473:pathology*; D014945:Wound Healing / Q000187:drug effects*
D010087:Oxides; D002713:Chlorine; C041955:tetrachlorodecaoxide