title: Middermal elastolysis in two patients with lupus erythematosus.
abstract: Despite lupus erythematosus (LE) being considered a "connective tissue disease," little has been written about the elastic fiber changes in the skin of affected patients. We report our histologic findings in two patients with unusual cutaneous lesions. Elastic fiber loss was noted, and scattered giant cells with elastic fiber phagocytosis were prominent in one patient. The findings are similar to those described for middermal elastolysis. Other authors have reported patients with LE and elastic fiber loss resembling anetoderma. We believe that a spectrum of elastic fiber changes can occur in patients with LE and may be induced by infiltrating lymphocytes and/or circulating antibodies.
authors: Department of Medicine, Vanderbilt University, Nashville, Tennessee, USA.
authors: A S
authors: AS
authors: Boyd
authors: L E
authors: LE
authors: King
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000974:Antibodies, Antinuclear / Q000032:analysis; D000068579:Celecoxib; D003483:Cutis Laxa / Q000188:drug therapy / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D003879:Dermatologic Agents / Q000627:therapeutic use; D020405:Dermis / Q000473:pathology*; D004359:Drug Therapy, Combination; D004547:Elastic Tissue / Q000276:immunology / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D011720:Pyrazoles; D013449:Sulfonamides / Q000627:therapeutic use; D014221:Triamcinolone / Q000627:therapeutic use
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D000974:Antibodies, Antinuclear; D003879:Dermatologic Agents; D005938:Glucocorticoids; D011720:Pyrazoles; D013449:Sulfonamides; D014221:Triamcinolone; D006886:Hydroxychloroquine; D000068579:Celecoxib