Parental cancer as a risk factor for nine common childhood malignancies.
The nationwide Swedish Family-Cancer Database was used to analyse childhood tumours among 8158 offspring by parental cancers. The results showed 2-fold familial increases for nervous system cancers and lymphomas, a 6.4-fold increase for endocrine tumours, a 60-fold increased risk for retinoblastomas but no excess risk for leukaemia and Wilms tumour.
Hemminki
K
K
Department of Biosciences at Novum, Karolinska Institute, 141 57 Huddinge, Sweden.
Mutanen
P
P
D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000453:epidemiology / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004701:Endocrine Gland Neoplasms / Q000453:epidemiology / Q000235:genetics; D006801:Humans; D007938:Leukemia / Q000453:epidemiology / Q000235:genetics; D008223:Lymphoma / Q000453:epidemiology / Q000235:genetics; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology / Q000235:genetics*; D010290:Parents; D012175:Retinoblastoma / Q000453:epidemiology / Q000235:genetics; D012307:Risk Factors; D009396:Wilms Tumor / Q000453:epidemiology / Q000235:genetics