title: Long-term effect of fibre supplement and reduced energy intake on body weight and blood lipids in overweight subjects.
abstract: A weight-reducing potential has been ascribed to high dietary fibre intake. To investigate the practical reliability of this hypothesis, fifty-three moderately overweight females (BMI > 27.5 kg/m2) on reduced energy intake (1200 kcal/day) were treated for 24 weeks with a fibre supplement on a randomly, double-blind, placebo-controlled basis. The fibre was administered as an initial dose of 6 g and a maintenance dose of 4 g. Body weight and blood pressure were recorded weekly during the first 3 months and thereafter every second week. Blood samples were drawn at start and at end of the study. Initial body weights were 75.6 +/- 1.6 kg in the fibre group versus 75.5 +/- 1.6 kg in the placebo group. After treatment, mean weight loss in the fibre group was 8.0 kg versus 5.8 kg in the placebo group (p < 0.05). Systolic and diastolic blood pressures were significantly reduced in both groups without differences between the groups. Serum concentrations of cholesterol, triglycerides and uric acid were significantly reduced in the group with reduced energy intake, whereas no additional effect was observed when fibre was supplemented. Serum concentrations of potassium and sodium did not change significantly. The results suggest that a dietary fibre supplement in combination with a hypocaloric diet is of value as an adjunct in the management of overweight.
authors: Laboratory of Gastroenterology, University Hospital of Tromsø, Norway. gsb42nor@aol.com
authors: G S
authors: GS
authors: Birketvedt
authors: J
authors: J
authors: Aaseth
authors: J R
authors: JR
authors: Florholmen
authors: K
authors: K
authors: Ryttig
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004038:Diet, Reducing; D004043:Dietary Fiber / Q000008:administration & dosage*; D004311:Double-Blind Method; D002149:Energy Intake; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000188:drug therapy*; D015431:Weight Loss
chemical_list: D004043:Dietary Fiber; D008055:Lipids