[Use of vilosen in the treatment of radiation damage of the immune system].
The possibility of vilosen usage for the immune system damage liquidation was studied. Rats obtained discrete rentgen irradiation during 1 month in the total dose of 4 Gr. Mice obtained internal 131I irradiation in a dose of 9.25 kBk/g. It was established that thymus and spleen masses, quantity of their cells, blood leukocytes and antibody production decreased by as external and internal irradiation. Irradiated animals treated with vilosen restored their immune system functional state partly or completely. The preparation was assumed to be used for the correction of immune system radiation damage.
Tron'ko
M D
MD
V. P. Komissarenko Institute of Endocrinology and Metabolism of Medical Sciences of Ukraine, Kiev.
Sydorenko
D S
DS
Bykova
L M
LM
Goidash
M M
MM
Boiko
M G
MG
Synel'nikova
G L
GL
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D007107:Immune System / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000276:immunology; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000737:chemistry / Q000276:immunology; D014020:Tissue Extracts / Q000737:chemistry / Q000627:therapeutic use*; D014965:X-Rays / Q000009:adverse effects
D000276:Adjuvants, Immunologic; D011837:Radiation-Protective Agents; D014020:Tissue Extracts