Clinical and immunological features of patients with interleukin-5-producing T cell clones and eosinophilia.
Recent work suggests that in some patients with the hypereosinophilic syndrome, a clone of abnormal T cells produces large amounts of interleukin-5. In this study, we examined 60 patients with idiopathic eosinophilia. Sixteen patients had circulating T cells with an aberrant immunophenotype that, in most cases, were associated with different forms of skin inflammation. The abnormal T cells produced large amounts of interleukin-5, which may have increased eosinophil differentiation in the bone marrow of these patients.
Simon
H U
HU
Department of Pharmacology, University of Bern, Switzerland. hus@pki.unibe.ch
Plötz
S G
SG
Simon
D
D
Dummer
R
R
Blaser
K
K
D002999:Clone Cells; D004804:Eosinophils / Q000473:pathology; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000276:immunology* / Q000473:pathology*; D016130:Immunophenotyping; D015848:Interleukin-5 / Q000096:biosynthesis*; D016131:Lymphocyte Subsets / Q000145:classification; D016399:Lymphoma, T-Cell / Q000209:etiology; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
D015848:Interleukin-5