Mariannaepyrone--a new inhibitor of thromboxane A2 induced platelet aggregation.
Mariannaeapyrone ((E)-2-(1,3,5,7-tetramethyl-5-nonenyl)-3,5-dimethyl-6-hydroxy-4H-pyran-4-one) is a new fungal metabolite isolated from fermentations of the common mycophilic deuteromycete Mariannaea elegans. The chemical structure of the 4-pyrone was determined by spectroscopic techniques. Mariannaeapyrone is a selective inhibitor of the thromboxane A2 induced aggregation of human platelets, whereas only weak cytotoxic and antimicrobial effects could be observed.
Fabian
K
K
Lehrbereich Biotechnologie der Universität, Kaiserslautern, Germany.
Anke
T
T
Sterner
O
O
D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D005285:Fermentation; D006801:Humans; D066298:In Vitro Techniques; D003904:Mitosporic Fungi / Q000737:chemistry* / Q000254:growth & development; D008968:Molecular Conformation; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D011753:Pyrones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D013928:Thromboxane A2 / Q000494:pharmacology*
D010975:Platelet Aggregation Inhibitors; D011753:Pyrones; C426846:mariannaeapyrone; D013928:Thromboxane A2