Membranous glomerulonephritis in a patient with inherited activated protein C resistance.
We present a patient with membranous glomerulonephritis, several clinical complications of the antiphospholipid syndrome and ulcerative colitis, but without lupus anticoagulant and antiphospholipid/cofactor antibodies. Immunological studies--other antibodies--were negative and failed to show enough criteria for any autoimmune diseases. Evaluation of her laboratory tests for hereditary thrombophilia revealed a heterozygous form of the Leiden mutation that might be associated with widespread vasculopathy. An interesting possibility is that the inherited activated protein C resistance could be an additional risk factor for vaso-occlusive manifestations appearing as a clinical sign of cardiovascular diseases and nephropathy.
Regéczy
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3rd Department of Internal Medicine, University Medical School, Debrecen, Hungary.
Lakos
G
G
Balogh
I
I
Kappelmayer
J
J
Kiss
E
E
D020016:Activated Protein C Resistance / Q000150:complications / Q000235:genetics*; D000328:Adult; D016736:Antiphospholipid Syndrome / Q000150:complications; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000150:complications*; D006801:Humans; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications