title: [Orbital metastasis in malignant melanoma].
abstract: We report the case of a 60-year-old man presenting bilateral progressive proptosis with diplopia, weight loss, tachycardia, nervosity, and stomach pain. These signs seemed at first to favor a diagnosis of Graves'ophthalmopathy. Thyroid tests were negative and the initial orbital CT scan was considered normal. A new radiological investigation 4 months later in our hospital revealed typical hypertrophy of the extraocular muscles compatible with orbital metastasis. The systemic investigations demonstrated a pulmonary tumor, multiple hepatic lesions, and several pigmented nodules of gastric mucosa. The pathology of pulmonary and gastric specimens confirmed the diagnosis of malignant melanoma. The primary lesion remains unknown. The authors discuss the differential diagnoses of orbital metastasis and the radiological characteristics of orbital metastasis in malignant melanoma.
authors: Fondation ophtalmologique A. de Rothschild, 25-29, rue Manin, 75019 Paris, France.
authors: G L
authors: GL
authors: Pedroli
authors: M
authors: M
authors: Hamedani
authors: P
authors: P
authors: Barraco
authors: A
authors: A
authors: Oubaaz
authors: S
authors: S
authors: Morax
mesh_terms: D003937:Diagnosis, Differential; D004172:Diplopia / Q000209:etiology; D005094:Exophthalmos / Q000209:etiology; D006111:Graves Disease / Q000175:diagnosis; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000175:diagnosis / Q000556:secondary*; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000175:diagnosis / Q000556:secondary*