Acetylsalicylic acid reduces ischemia-induced proliferation of dentate cells in gerbils.
Transient global ischemia causes neurogenesis in the dentate gyrus of adult rodents. Ischemic insults to rodents also induce cyclooxygenase-2 (COX-2), an isoform of cyclooxygenases (COXs) and a rate-limiting enzyme for prostanoid synthesis. In the present experiments, adult Mongolian gerbils were chronically treated with acetylsalicylic acid (ASA), a non-selective COX inhibitor, and the proliferation of cells in the dentate gyrus was examined under ischemia. It was proved that BrdU-labeled cells in the dentate gyrus were significantly reduced in number following ASA treatment after 10 min global ischemia. The result strongly suggests that COX, probably COX-2, and prostanoids play an important role in the proliferation of neural cells after ischemia in gerbils.
Kumihashi
K
K
Department of Regulation Biology, Graduate School of Science and Engineering, Saitama University, Urawa, Japan.
Uchida
K
K
Miyazaki
H
H
Kobayashi
J
J
Tsushima
T
T
Machida
T
T
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology*; D002545:Brain Ischemia / Q000473:pathology*; D001973:Bromodeoxyuridine / Q000494:pharmacology; D017536:Carotid Artery, Common / Q000502:physiology; D002455:Cell Division / Q000187:drug effects; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D018891:Dentate Gyrus / Q000473:pathology*; D005849:Gerbillinae; D007274:Injections, Intraperitoneal; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D000963:Antimetabolites; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases; D001973:Bromodeoxyuridine; D001241:Aspirin