title: [Effect on microelements on biosynthes of secondary metabolites in the fungus Penicillium citrinum Thom VKM F-1079].
abstract: Penicillium citrinum VKM F-1079 was found to produce clavine ergot alkaloids and citrinin, a secondary O-heterocyclic metabolite. Citrinin was produced in the idiophase, whereas the production of ergot alkaloids paralleled fungal growth. The addition of manganese ions to the growth medium stimulated the biosynthesis of both citrinin and ergot alkaloids. Zinc ions stimulated only citrinin synthesis. The presence of these microelements in the growth medium influenced the proportion between the ergot alkaloids synthesized. Copper, manganese, and iron ions affected but little fungal growth and alkaloid production. The effect of microelements on the main kinetic parameters of growth and alkaloid production was studied.
authors: Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr. Nauki 5, Pushchino, Moscow oblast, 142290 Russia.
authors: A G
authors: AG
authors: Kozlovskiĭ
authors: V P
authors: VP
authors: Zhelifonova
authors: N G
authors: NG
authors: Vinokurova
authors: S M
authors: SM
authors: Ozerskaia
mesh_terms: D002953:Citrinin / Q000378:metabolism*; D004876:Ergot Alkaloids / Q000378:metabolism*; D008345:Manganese / Q000494:pharmacology*; D010407:Penicillium / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology*
chemical_list: D004876:Ergot Alkaloids; D002953:Citrinin; D008345:Manganese; D015032:Zinc