title: Role of the anterior visceral endoderm in restricting posterior signals in the mouse embryo.
abstract: Recent genetic and embryological experiments have demonstrated that head formation in the mouse embryo is dependent on signals provided by two organising centers during gastrulation, the anterior visceral endoderm (AVE) and the anterior primitive streak (also called the Early Gastrula Organiser, EGO). However the molecular nature of the signals triggering anterior neural formation from the epiblast is not clearly understood. The analysis of mouse mutants has allowed the identification of some of the molecular players involved in the process of head formation. In this review, we describe different mutant embryos in which impairment of visceral endoderm function leads to similar defects in antero-posterior axis specification. These phenotypes are consistent with a role of the AVE in protecting anterior embryonic regions from signals that promote posterior development. We propose that a genetic cascade in the AVE, involving HNF3beta, Lim1, Otx2, Smad2 and ActRIB, leads to the production of secreted TGFbeta antagonists that protect the anterior epiblast region from Nodal signalling.
authors: Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS/INSERM/Université Louis Pasteur, Illkirch, Strasbourg, France.
authors: A
authors: A
authors: Perea-Gomez
authors: M
authors: M
authors: Rhinn
authors: S L
authors: SL
authors: Ang
mesh_terms: D030201:Activin Receptors, Type I; D000818:Animals; D029681:Arabidopsis Proteins; D019521:Body Patterning; D005326:Fetal Proteins; D005775:Gastrula / Q000166:cytology; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins; D055458:Left-Right Determination Factors; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000502:physiology; D055457:Nodal Protein; D020897:Organizers, Embryonic; D051857:Otx Transcription Factors; D010940:Plant Proteins / Q000235:genetics / Q000502:physiology; D017978:Receptors, Growth Factor / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction; D020825:T-Box Domain Proteins / Q000235:genetics / Q000502:physiology; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D000098908:Brachyury Protein
chemical_list: D030201:Activin Receptors, Type I; D029681:Arabidopsis Proteins; D005326:Fetal Proteins; D018398:Homeodomain Proteins; D055458:Left-Right Determination Factors; D009419:Nerve Tissue Proteins; D055457:Nodal Protein; D051857:Otx Transcription Factors; D010940:Plant Proteins; D017978:Receptors, Growth Factor; D020825:T-Box Domain Proteins; D015534:Trans-Activators; D016212:Transforming Growth Factor beta; D000098908:Brachyury Protein; C101547:CER protein, Arabidopsis; C526008:Nodal protein, mouse; C497660:Otx2 protein, mouse