Effect of amantadine on weight gain during olanzapine treatment.
Patients treated with olanzapine may gain weight, especially in the first months of therapy. Amantadine (100-300 mg/day) was started in 12 patients having a mean weight gain of 7.3 kg during olanzapine treatment. The patients' weight stabilised and over 3-6 months they lost an average of 3.5 kg. No clinical deterioration occurred and no adverse effects were reported. These observations merit confirmation in randomised, controlled trials.
Floris
M
M
Department of Psychiatry, Hôpital Notre-Dame, Avenue Delmée 9, B-7500, Tournai, Belgium.
Lejeune
J
J
Deberdt
W
W
D000328:Adult; D000547:Amantadine / Q000009:adverse effects / Q000627:therapeutic use*; D014150:Antipsychotic Agents / Q000009:adverse effects*; D001569:Benzodiazepines; D015259:Dopamine Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D000077152:Olanzapine; D010890:Pirenzepine / Q000009:adverse effects* / Q000031:analogs & derivatives*; D011618:Psychotic Disorders / Q000150:complications / Q000188:drug therapy / Q000523:psychology; D015430:Weight Gain / Q000187:drug effects*
D014150:Antipsychotic Agents; D015259:Dopamine Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D000547:Amantadine; D000077152:Olanzapine