title: Dissociation of infectivity and pathogenicity in Borrelia burgdorferi.
abstract: Clonal Borrelia burgdorferi N40 (cN40) passaged 75 times in vitro (N40-75) infects mice but does not cause disease. N40-75 passaged 45 times further in vitro (N40-120) was no longer infectious and lacked genes encoded on linear plasmids 38 and 28-1, among other differences. These data suggest that B. burgdorferi cN40, N40-75, and N40-120 have distinct phenotypes that can be used to dissect the genetic elements responsible for pathogenicity and infectivity.
authors: Section of Rheumatology, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
authors: V
authors: V
authors: Thomas
authors: J
authors: J
authors: Anguita
authors: S
authors: S
authors: Samanta
authors: P A
authors: PA
authors: Rosa
authors: P
authors: P
authors: Stewart
authors: S W
authors: SW
authors: Barthold
authors: E
authors: E
authors: Fikrig
mesh_terms: D000818:Animals; D015748:Borrelia burgdorferi Group / Q000235:genetics* / Q000472:pathogenicity*; D004195:Disease Models, Animal; D008193:Lyme Disease / Q000209:etiology; D051379:Mice; D008809:Mice, Inbred C3H; D010957:Plasmids