The C. elegans gon-2 gene encodes a putative TRP cation channel protein required for mitotic cell cycle progression.
The C. elegans gon-2 gene is required for the post-embryonic mitotic cell divisions of the gonadal precursor cells. A single major transcript of approximately 6.7 kb is derived from the gon-2 locus. This mRNA encodes a protein related to the TRP family of cation channels and has a high degree of similarity to several vertebrate genes, including melastatin. Mutant alleles of gon-2 affect evolutionarily conserved amino acid residues. Northern analyses suggest that gon-2 expression is not limited to gonadal tissues.
West
R J
RJ
Department of Biological Sciences, 115 Gilman, Dartmouth College, Hanover NH 03755, USA.
Sun
A Y
AY
Church
D L
DL
Lambie
E J
EJ
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics* / Q000502:physiology; D015220:Calcium Channels / Q000235:genetics* / Q000502:physiology; D002453:Cell Cycle / Q000235:genetics / Q000502:physiology*; D002455:Cell Division / Q000502:physiology; D017124:Conserved Sequence / Q000235:genetics; D017238:Genes, Helminth / Q000235:genetics*; D006066:Gonads / Q000166:cytology / Q000254:growth & development; D008969:Molecular Sequence Data; D009154:Mutation; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D050052:TRPC Cation Channels; D014158:Transcription, Genetic
D015220:Calcium Channels; D012333:RNA, Messenger; D050052:TRPC Cation Channels; C096351:transient receptor potential cation channel, subfamily C, member 1