title: 2,2-Dimethyl-2H-anthra[2,3-b]pyran-6,11-diones: a new class of cytotoxic compounds.
abstract: The synthesis and cytotoxic activity of some new 2,2-dimethyl-2H-anthra[2,3-b]pyran-6,11-diones is described. Certain compounds possess interesting activity against murine leukemia L-1210 cells. Relationships between the biological activity and the pyrano-ring conformations are discussed.
authors: Laboratory of Pharmacognosy, University of Athens, Greece.
authors: E
authors: E
authors: Melliou
authors: P
authors: P
authors: Magiatis
authors: S
authors: S
authors: Mitaku
authors: A L
authors: AL
authors: Skaltsounis
authors: A
authors: A
authors: Pierré
authors: G
authors: G
authors: Atassi
authors: P
authors: P
authors: Renard
mesh_terms: D000818:Animals; D000873:Anthracenes / Q000138:chemical synthesis / Q000494:pharmacology; D000880:Anthraquinones / Q000138:chemical synthesis / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000145:classification / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005434:Flow Cytometry; D020128:Inhibitory Concentration 50; D051379:Mice; D008958:Models, Molecular; D011714:Pyrans / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000873:Anthracenes; D000880:Anthraquinones; D000970:Antineoplastic Agents; D011714:Pyrans