Factors associated with increased aqueous flare in psoriasis.
OBJECTIVE
To evaluate the changes in aqueous flare in psoriasis patients and to identify the factors that influence the level of aqueous flare.


METHODS
We examined the 68 eyes of 34 psoriasis patients and the 68 eyes of 34 healthy subjects with a laser flare-cell meter. Complete dermatologic and ophthalmic examinations were performed on the psoriasis patients.


RESULTS
Flare was significantly higher in psoriasis patients than in normal controls (P <.000l). The factors that increased flare significantly were age and Psoriasis Area and Severity Index. Flare was not significantly associated with sex, psoriasis type, duration of disease, and cyclosporin therapy. A flare increase was significantly correlated with serum total protein and immunoglobulin (Ig) A, but not with albumin, IgG, and IgM.


CONCLUSIONS
Psoriasis patients, even without ocular symptoms, had slight damage to the blood-aqueous barrier. Multiple linear regression analysis showed that flare had the strongest correlation with the severity of psoriasis.
Okamoto
F
F
Department of Ophthalmology, University Hospital of Tsukuba, Tsukuba, Japan.
Umebayasi
Y
Y
Ohtsuka
F
F
Hommura
S
S
D000328:Adult; D001082:Aqueous Humor / Q000378:metabolism*; D018916:Blood-Aqueous Barrier; D002199:Capillary Permeability; D016572:Cyclosporine / Q000627:therapeutic use; D003941:Diagnostic Techniques, Ophthalmological; D005136:Eye Proteins / Q000378:metabolism*; D005260:Female; D006801:Humans; D008027:Light; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy / Q000378:metabolism*; D012307:Risk Factors; D012542:Scattering, Radiation
D005136:Eye Proteins; D016572:Cyclosporine