Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants.
MeOH extracts, fractions and pure substances from Musanga cecropioides, Cecropia species and Crataegus oxyacantha /C. monogyna were screened by using an in vitro bio-assay based on the inhibition of Angiotensin Converting Enzyme (ACE), as measured from the enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine. Phenolic acids showed no significant ACE-inhibition whereas flavonoids and proanthocyanidins demonstrated inhibitory activity at 0.33 mg/ml using this test system.
Lacaille-Dubois
Laboratoire de Pharmacognosie, Unité de Molecules d'Intérêt Biologique, Faculté de Pharmacie, Université de Bourgogne, Dijon, France. malacd@u-bourgogne.fr
Franck
U
U
Wagner
H
H
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D000872:Anthocyanins / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D044945:Proanthocyanidins
D000806:Angiotensin-Converting Enzyme Inhibitors; D000872:Anthocyanins; D005419:Flavonoids; D010936:Plant Extracts; D044945:Proanthocyanidins; C013221:proanthocyanidin