Successful engraftment of a second transplant using non-myeloablative conditioning as treatment for graft failure following unrelated donor BMT.
A 32-year-old man with CML in second chronic phase developed primary graft failure following matched unrelated donor transplantation using cryopreserved marrow cells. He was successfully regrafted within 60 days from a second fully matched donor using a non-myeloablative conditioning regimen, with minimal toxicity. He remains in complete haematological, cytogenetic and molecular remission 2 years after second transplant. We believe that reduced intensity or 'mini-transplants' may be preferable for patients requiring second allografts which are usually associated with a high transplant-related mortality.
Byrne
J L
JL
Department of Haematology, Nottingham City Hospital, Nottingham, UK.
Musuka
C
C
Davy
B
B
Donovan
L
L
Russell
N H
NH
D000328:Adult; D016026:Bone Marrow Transplantation / Q000379:methods; D006084:Graft Rejection / Q000628:therapy*; D006085:Graft Survival; D006648:Histocompatibility / Q000276:immunology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008297:Male; D012086:Reoperation; D019172:Transplantation Conditioning / Q000379:methods*