title: Singular anti-RNA virus-directed proteins.
abstract: OBJECTIVE
  To additionally purify and characterise the anti-RNA virus-directed protein termed p14.
  
  
  METHODS
  Antiviral assays of p14 against RNA and DNA viruses were carried out and its antigenic similarities with chicken interferon (CIFN) were studied. HPLC-Reverse Phase of p14 was performed to further purify p14.
  
  
  RESULTS
  p14 showed antiviral activity against RNA viruses only and not against DNA viruses. It was antigenically distinct from CIFN. Purification of p14 yielded three proteins with antiviral activity, which had different physico-chemical properties than those described for interferons.
  
  
  CONCLUSIONS
  The data presented on the antiviral, immunological and physico-chemical properties, establish the unique nature of p14 vis-á-vis those of interferons.
authors: Department. of Immunology, Haffkine Institute for Training, Research and Testing, Parel, Mumbai - 400 012, India. Ravi_Rayanade@hotmail.com
authors: R J
authors: RJ
authors: Rayanade
authors: K
authors: K
authors: Banerjee
authors: M V
authors: MV
authors: Shirodkar
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D002851:Chromatography, High Pressure Liquid; D004267:DNA Viruses / Q000187:drug effects*; D015801:Helminth Proteins / Q000302:isolation & purification* / Q000494:pharmacology*; D009124:Muscle Proteins / Q000302:isolation & purification* / Q000494:pharmacology*; D012328:RNA Viruses / Q000187:drug effects*; D012680:Sensitivity and Specificity; D000096985:Calponins
chemical_list: D015801:Helminth Proteins; D009124:Muscle Proteins; C118619:calponin homolog protein, Schistosoma japonicum; D000096985:Calponins