Human memory T cells: lessons from stem cell transplantation.
Animal models have revealed the rules for the organization of mature T-cell pools. However, in humans, little is known about memory T cells, which differ in lifespan and in the number of times that the same antigen is encountered. Here, Nathalie Rufer and colleagues discuss their findings in stem-cell-transplanted patients, which provide interesting data on the human T-cell compartment.
Rufer
N
N
Division of Immunology and Allergology, University Hospital of Geneva, 24 rue Micheli-du-Crest, CH-1211 14, Genève, Switzerland.
Helg
C
C
Chapuis
B
B
Roosnek
E
E
D000818:Animals; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006706:Homeostasis / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology*; D008213:Lymphocyte Activation / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*