title: Cortical degeneration associated with phonologic and semantic language impairments in AD.
abstract: OBJECTIVE
  To compare the pattern of cortical degeneration associated with different language deficits in cases of AD.
  
  
  METHODS
  Cases for detailed neuropathologic analysis (Patients 1 and 2) were selected because of their detailed clinical and neuropsychological assessments of language dysfunction in AD. Patient 1 had severe phonologic impairment with relatively preserved semantic aspects of language. Patient 2 had severe semantic language impairment with relatively preserved phonologic skills. The tissue volume of cortical regions associated with speech and language function was measured using standardized three-dimensional techniques. Neuronal areal fraction was also measured from histologic tissue samples. The degree of volume atrophy and neuronal loss was calculated in comparison to control measures (n = 10 men and 11 women). Measurements more than 2 SD from controls were considered abnormal.
  
  
  RESULTS
  Both AD cases had significant degeneration of the superior temporal gyrus and area 37. Cortical language regions affected only in Patient 1 included the anterior and posterior insula and part of Broca's area. In contrast, Patient 2 had a greater degree of degeneration in the temporal gyri and their white matter connections with the hippocampal/entorhinal complex.
  
  
  CONCLUSIONS
  Variable patterns of neurodegeneration underlie the clinical differences observed in patients with AD. Disconnection within the temporal lobe appears associated with semantic language difficulties, whereas disconnection of the anterior and posterior language areas appears associated with phonologic and grammatical impairment.
authors: Prince of Wales Medical Research Institute, Randwick, Sydney, Australia. J.Harasty@unsw.edu.au
authors: J A
authors: JA
authors: Harasty
authors: G M
authors: GM
authors: Halliday
authors: J
authors: J
authors: Xuereb
authors: K
authors: K
authors: Croot
authors: H
authors: H
authors: Bennett
authors: J R
authors: JR
authors: Hodges
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology* / Q000523:psychology*; D001921:Brain / Q000473:pathology*; D005260:Female; D006801:Humans; D008037:Linguistics; D008297:Male; D009483:Neuropsychological Tests; D010700:Phonetics; D012660:Semantics