Automated synthesis and purification of [18F]bromofluoromethane at high specific radioactivity.
[18F]Bromofluoromethane was synthesised from dibromomethane by substitution of bromine with [18F]fluoride. The synthesis and separation of the [18F]bromofluoromethane were automated. [18F]Bromofluoromethane was used to convert a phenolic and a thiophenolic precursor into a labelled ether and thioether, respectively. The specific radioactivity of these labelled products was determined with both high-performance liquid chromatography (with UV-absorbance detection) and liquid chromatography (with mass spectrometric detection). The median for the specific radioactivity, corrected at the end of radionuclide production, was 934GBq/micromol (range 40-9900 GBq/micromol; n = 83).
Bergman
J
J
Radiopharmaceutical Chemistry Laboratory, Turku PET Centre, Finland.
Eskola
O
O
Lehikoinen
P
P
Solin
O
O
D001331:Automation / Q000295:instrumentation / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D017357:Cyclotrons; D005462:Fluorine Radioisotopes; D006842:Hydrocarbons, Brominated / Q000138:chemical synthesis*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D013058:Mass Spectrometry
D005462:Fluorine Radioisotopes; D006842:Hydrocarbons, Brominated; D006845:Hydrocarbons, Fluorinated; D007202:Indicators and Reagents; C425968:bromofluoromethane