Intracerebroventricular administration of somatostatin prevents and attenuates adjuvant arthritis.
The effects of somatostatin on the development of adjuvant arthritis induced by Mycobacterium butyricum were studied. Somatostatin was injected into the lateral cerebral ventricle every day for 14 days beginning on the first day of mycobacteria inoculation in the preventive group. In the treatment group, somatostatin was injected from day 17 until day 30 post-mycobacteria inoculation. Arthritis was evaluated by measuring ankle joint circumference and diameter as well as microscopic examination of ankle joint sections. Somatostatin profoundly inhibited the development of adjuvant arthritis and an anti-inflammatory action was observed in the treatment group. These results suggest that somatostatin has a central action that can prevent or attenuate symptoms associated with arthritis.
Elhassan
A M
AM
Department of Orthopedic Surgery, Karolinska Institute, Huddinge Hospital, S-141 86, Huddinge, Sweden. adlan.elhassan@kfcmail.hs.sll.se
Adem
A
A
Papadogiannakis
N
N
Suliman
I
I
Gad
A
A
Lindgren
J U
JU
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy* / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D006614:Hindlimb; D007276:Injections, Intraventricular; D007596:Joints / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013004:Somatostatin / Q000008:administration & dosage* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D013004:Somatostatin