Identification of four novel dinucleotide repeat polymorphisms in the IL-2 and IL-2beta receptor genes.
Two polymorphic regions have been described within the IL-2 and IL-2 receptor beta genes comprising 15 and 8 alleles, respectively. Whether these polymorphisms have biologic importance is unknown, although they have been variably identified in associated with certain chronic disease states. We report here the detection of four new alleles designated IL-2 A* (122 bp), IL-2R-2 (169 bp), IL-2R 0 (165 bp), and IL-2R 9 (147 bp) in patients with rheumatoid arthritis and normal controls from the Pacific Northwest. The number of alleles now recognized at these loci within the IL-2 and IL-2Rbeta genes increases to 16 and 12, respectively.
Khani-Hanjani
A
A
Department of Medicine, Vancouver General Hospital, the University of British Colombia, Canada.
Hoar
D
D
Horsman
D
D
Lacaille
D
D
Chalmers
A
A
Keown
P
P
D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics* / Q000276:immunology; D018900:Dinucleotide Repeats; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics*; D011110:Polymorphism, Genetic; D015375:Receptors, Interleukin-2 / Q000235:genetics*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2