title: Buprenorphine treatment of pregnant opioid--dependent women: maternal and neonatal outcomes.
abstract: This open-label prospective study examined maternal and neonatal safety and efficacy outcome measures during and following prenatal buprenorphine exposure. Three opioid-dependent pregnant women received 8 or 12 mg sublingual buprenorphine tablets daily for 15-16 weeks prior to delivery. Results showed that buprenorphine in combination with comprehensive prenatal care was safe and effective in these women. Prenatal exposure to buprenorphine resulted in normal birth outcomes, a mean of 4.33 days (minimum possible=4) hospitalization, and a 'relatively mild' neonatal abstinence syndrome comprised primarily of tremors (disturbed), hyperactive moro and shortened sleep after feeding. The infants required no pharmacological treatment. Onset of neonatal abstinence signs occurred within the first 12 h after birth, peaked by 72 h and returned to below pre-12 h levels by 120 h. It is concluded that buprenorphine has potential utility for the treatment of pregnant opioid-dependent women.
authors: Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224-6823, USA.
authors: R E
authors: RE
authors: Johnson
authors: H E
authors: HE
authors: Jones
authors: D R
authors: DR
authors: Jasinski
authors: D S
authors: DS
authors: Svikis
authors: N A
authors: NA
authors: Haug
authors: L M
authors: LM
authors: Jansson
authors: W B
authors: WB
authors: Kissin
authors: G
authors: G
authors: Alpan
authors: M E
authors: ME
authors: Lantz
authors: E J
authors: EJ
authors: Cone
authors: D G
authors: DG
authors: Wilkins
authors: A S
authors: AS
authors: Golden
authors: G R
authors: GR
authors: Huggins
authors: B M
authors: BM
authors: Lester
mesh_terms: D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006304:Health Status; D006801:Humans; D007223:Infant; D009292:Narcotic Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D009293:Opioid-Related Disorders / Q000188:drug therapy*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome
chemical_list: D009292:Narcotic Antagonists; D002047:Buprenorphine