[Peptidergic mechanisms of hypothermia-induced seizures in rats during early ontogenesis].
Arginine-vasopressin reduced the tonic-clonic seizures' latency as well as the duration of the seizures brain-stem generalisation on the 3rd and 5th postpartum days in rats. The reduced latency was also observed after the PACAP38 low doses administration, whereas higher doses diminished and then enhanced the threshold of generalised hyperthermia-induced seizures on the 3rd and 5th days and the 7th and 9th days, resp. The arginine-vasopressin-treated animals had a dramatically enhanced duration of the tonic-clonic seizures up to the epileptic status on the 9th postpartum day. The findings suggest the PACAP involvement in mechanisms of experimental febrile seizures through its effect upon arginine-vasopressin neurosecretion.
Chepurnova
N E
NE
Lomonosov State University, 119899, Vorobievy Gory, Moscow, Russia.
Ponomarenko
A A
AA
Chepurnov
S A
SA
D000818:Animals; D000831:Animals, Newborn; D001127:Arginine Vasopressin / Q000494:pharmacology; D001831:Body Temperature; D004789:Enzyme Activation; D006361:Heating; D009479:Neuropeptides / Q000494:pharmacology; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D051381:Rats; D012640:Seizures / Q000209:etiology / Q000378:metabolism*; D013226:Status Epilepticus / Q000209:etiology / Q000378:metabolism
C495403:Adcyap1 protein, rat; D009479:Neuropeptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D001127:Arginine Vasopressin