title: Identification of co-mutagenic chlorinated harmans in final effluent from a sewage treatment plant.
abstract: Harman (1-methyl-9H-pyrido[3,4-b]indole) reacted readily with sodium hypochlorite in an aqueous medium to give the mono-chlorinated derivatives, which reportedly have greater co-mutagenic activity than harman in the presence of o-toluidine toward Salmonella typhimurium TA 98 with S9 mix. Mono-chlorinated harmans were detected by concentration using blue rayon (BR) and GC/MS analysis in the final effluent from a sewage treatment plant in Shizuoka, Japan. The amounts adsorbed for 24h were 1-45ng/gBR for mono-chlorinated harman and 110-730ng/gBR for harman.
authors: Institute for Environmental Sciences, University of Shizuoka, 52-1 Yada, 422-8526, Shizuoka, Japan.
authors: H
authors: H
authors: Fukazawa
authors: H
authors: H
authors: Matsushita
authors: Y
authors: Y
authors: Terao
mesh_terms: D001711:Biotransformation; D002713:Chlorine / Q000737:chemistry; D008401:Gas Chromatography-Mass Spectrometry; D006247:Harmine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000633:toxicity*; D007220:Industrial Waste; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics; D012722:Sewage
chemical_list: D007220:Industrial Waste; D009153:Mutagens; D012722:Sewage; D006247:Harmine; D002713:Chlorine; C005010:harman