Effect of potassium on Saccharomyces cerevisiae resistance to fluconazole.
Susceptibility of strain S288c of Saccharomyces cerevisiae to fluconazole was assayed in the presence and absence of KCl. Addition of 150 mM KCl renders the strain more sensitive to the antifungal agent. The effect is caused by the K(+) ion rather than the anion or the osmolarity of the medium. The increase in sensitivity does not modify the values of intracellular and extracellular pH established in the presence of KCl.
Stella
C A
CA
Departamento de Bioquímica Humana, Facultad de Medicina, Universidad de Buenos Aires, 1121 Buenos Aires, Argentina. cstella@fmed.uba.ar
Burgos
H I
HI
D000935:Antifungal Agents / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D011189:Potassium Chloride / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
D000935:Antifungal Agents; D011189:Potassium Chloride; D015725:Fluconazole