title: Lipiodol solution of a lipophilic agent, (188)Re-TDD, for the treatment of liver cancer.
abstract: Radiolabeled lipiodol has been used for targeting liver cancer. We developed a lipiodol solution of (188)Re-TDD (2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol) and investigated its feasibility for the treatment of liver cancer. The lipiodol solution of (188)Re-TDD was well-retained in the lipiodol phase in vitro. After injection through the tail veins of mice, high lung-uptake was investigated which is evidence of embolizing activity. We also found high accumulation in hepatoma after injection through the hepatic arteries of hepatoma-bearing rats. In conclusion, the lipiodol solution of (188)Re-TDD is a promising agent for liver cancer therapy.
authors: Department of Nuclear Medicine, Seoul National University, 28 Yungun-dong Chongro-ku, Seoul 110-744, Korea. jmjng@snu.ac.kr
authors: J M
authors: JM
authors: Jeong
authors: Y J
authors: YJ
authors: Kim
authors: Y S
authors: YS
authors: Lee
authors: J I
authors: JI
authors: Ko
authors: M
authors: M
authors: Son
authors: D S
authors: DS
authors: Lee
authors: J K
authors: JK
authors: Chung
authors: J H
authors: JH
authors: Park
authors: M C
authors: MC
authors: Lee
mesh_terms: D000818:Animals; D007459:Iodized Oil; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D008113:Liver Neoplasms / Q000532:radiotherapy*; D008114:Liver Neoplasms, Experimental / Q000532:radiotherapy*; D008168:Lung / Q000378:metabolism; D051379:Mice; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D011868:Radioisotopes; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012211:Rhenium; D012996:Solutions; D014018:Tissue Distribution
chemical_list: C431271:188Re 2,2,9,9-tetramethyl-4,7-diaza-1,10-decanedithiol; D009942:Organometallic Compounds; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D012996:Solutions; D012211:Rhenium; D007459:Iodized Oil