Long-term efficacy of torsemide compared with frusemide in cirrhotic patients with ascites.
BACKGROUND
Torsemide is a new loop diuretic that has shown, in short-term studies, to induce a longer and higher diuretic and natriuretic action than frusemide. However, torsemide long-term effects and complications have not been sufficiently investigated. The aim was to compare the efficacy and safety of torsemide versus frusemide in cirrhotic patients with uncomplicated ascites.


METHODS
Forty-six patients were randomized in two groups to receive torsemide 20 mg/day (n = 22) or frusemide 40 mg/day (n = 24). Both drugs were administered in association with spironolactone 200 mg/day. The initial doses of diuretics were increased every 3 days up to 60, 120 and 400 mg/day, respectively, if the body weight loss was less than 300 g/day or natriuresis was below 50 mEq/day.


RESULTS
Torsemide induced a significantly greater diuretic response than frusemide at 24 h and the maximum diuresis while mean diuresis was similar in both groups. Natriuresis was also higher with torsemide but the difference was not significant. The body weight loss, the treatment period, the ascites resolution and complications were similar in both groups. Diuretic doses were increased in two patients treated with torsemide and in nine patients treated with frusemide (P < 0.05).


CONCLUSIONS
These results show that torsemide is as effective and safe as frusemide for long-term treatment of cirrhotic patients with ascites.
Abecasis
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Liver Unit, Hospital de Gastroenterología Dr. B. Udaondo, Universidad del Salvador, School of Medicine, Buenos Aires, Argentina. fundhig@radar.com.ar
Guevara
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Miguez
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Cobas
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Terg
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D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001201:Ascites / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D016009:Chi-Square Distribution; D004232:Diuretics / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D005665:Furosemide / Q000008:administration & dosage*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy*; D008111:Liver Function Tests; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D011336:Probability; D012720:Severity of Illness Index; D013449:Sulfonamides / Q000008:administration & dosage*; D000077786:Torsemide; D016896:Treatment Outcome
D004232:Diuretics; D013449:Sulfonamides; D005665:Furosemide; D000077786:Torsemide