title: De novo malignant transformation of giant cell tumor of bone.
abstract: Two cases of malignant lesions are reported, both of which arose secondary to an originally benign giant cell tumor (GCT) of bone. The first case was a typical benign GCT, which occurred in the left proximal tibia of a 31-year-old woman. The tumor was treated by curettage and bone grafting. However, it recurred twice during 15 years of follow-up. The second recurrence showed that the lesion histologically had turned into malignant fibrous histiocytoma. The second case also started as an initially benign GCT that arose in the left distal femur of a 41-year-old man. The patient underwent curettage and bone grafting. The lesion recurred 13 years postoperatively. The histological appearance of the recurrent tumor showed it to be an osteogenic sarcoma. In both patients, radiation and never been given. Malignant transformation has rarely been reported in patients with GCT of bone who have not received radiation treatment.
authors: Department of Orthopaedic Surgery, Kobe University School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan.
authors: T
authors: T
authors: Marui
authors: T
authors: T
authors: Yamamoto
authors: H
authors: H
authors: Yoshihara
authors: M
authors: M
authors: Kurosaka
authors: K
authors: K
authors: Mizuno
authors: T
authors: T
authors: Akamatsu
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D005260:Female; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D018212:Giant Cell Tumor of Bone / Q000000981:diagnostic imaging* / Q000473:pathology; D018219:Histiocytoma, Benign Fibrous / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging / Q000473:pathology; D012516:Osteosarcoma / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology