title: A new diterpenoid with antispasmodic activity from Salvia cinnabarina.
abstract: From the leaf surface exudate of the aerial parts of Salvia cinnabarina a new secoisopimarane diterpenoid with a non-specific spasmolytic activity on histamine-, acetylcholine-, and barium chloride-induced contractions in the isolated guinea-pig ileum was obtained. The IC50 value obtained was comparable with that obtained for papaverine. The structure of 3,4-secoisopimara-4(18),7,15-triene-3-oic acid was established by 1D and 2D NMR spectroscopic techniques.
authors: Dipartimento di Chimica e Tecnologie Farmaceutiche e Alimentari, Università di Genova, Genova, Italy. romussi@dictfa.unige.it
authors: G
authors: G
authors: Romussi
authors: G
authors: G
authors: Ciarallo
authors: A
authors: A
authors: Bisio
authors: N
authors: N
authors: Fontana
authors: F
authors: F
authors: De Simone
authors: N
authors: N
authors: De Tommasi
authors: N
authors: N
authors: Mascolo
authors: L
authors: L
authors: Pinto
mesh_terms: D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000378:metabolism; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D019686:Lamiaceae; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015394:Molecular Structure; D010208:Papaverine / Q000494:pharmacology; D010276:Parasympatholytics / Q000302:isolation & purification* / Q000494:pharmacology; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*
chemical_list: C423882:3,4-secoisopimara-4(18),7,15-triene-3-oic acid; D004224:Diterpenes; D010276:Parasympatholytics; D006632:Histamine; D010208:Papaverine; D000109:Acetylcholine