Novel alpha-hydroxyethyl-polystyrene, alpha-chloroethyl-polystyrene and alpha-amino-oxyethyl-polystyrene linkers on the Multipin solid support for solid-phase organic synthesis.
A simple method for the generation of three novel linkers, alpha-hydroxyethyl-polystyrene, alpha-chloroethyl-polystyrene and alpha-amino-oxyethyl-polystyrene on Multipin supports (SynPhase Crowns) has been developed. Applications of these linkers have been successfully demonstrated for solid-phase synthesis of dipeptide, oxime, and hydroxamic acid compounds in good yields and purities.
Bui
C T
CT
Mimotopes Pty. Ltd., 11 Duerdin Street, Clayton, Victoria 3168, Australia.
Maeji
N J
NJ
Bray
A M
AM
D009930:Organic Chemicals / Q000138:chemical synthesis*; D011137:Polystyrenes / Q000737:chemistry*
D009930:Organic Chemicals; D011137:Polystyrenes