Mitochondrial potassium and chloride channels.
Channels selective for potassium or chloride ions are present in inner mitochondrial membranes. They probably play an important role in mitochondrial events such as the formation of delta pH and regulation of mitochondrial volume changes. Mitochondrial potassium and chloride channels could also be the targets for pharmacologically active compounds such as potassium channel openers and antidiabetic sulfonylureas. This review describes the properties, pharmacology, and current observations concerning the functional role of mitochondrial potassium and chloride channels.
Kicińska
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Laboratory of Intracellular Ion Channels, Nencki Institute of Experimental Biology, Warszawa, Poland.
D bska
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Kunz
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Szewczyk
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D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D018118:Chloride Channels / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D006801:Humans; D007425:Intracellular Membranes / Q000378:metabolism; D019157:Ischemic Preconditioning, Myocardial; D008928:Mitochondria / Q000378:metabolism*; D008929:Mitochondria, Heart / Q000378:metabolism; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism*; D011493:Protein Kinase C / Q000378:metabolism
D018118:Chloride Channels; D015221:Potassium Channels; D000255:Adenosine Triphosphate; D011493:Protein Kinase C