title: [Perfusion MR imaging of the heart with TrueFISP].
abstract: OBJECTIVE
  Development and test of a saturation-recovery TrueFISP (SR-Trufi) pulse sequence for myocardial perfusion MR imaging (MRI) using improved gradient hardware.
  
  
  METHODS
  Measurements were performed on a 1.5 T scanner with prototype gradients (50 mT/m, minimum rise time 300 microseconds). T1-weighted first-pass MRI of Gd-DTPA (0.025 mumol/kg) kinetics in the myocardium was performed using an SR-Trufi pulse sequence (TR/TE/alpha = 2.6 ms/1.4 ms/55 degrees) with a saturation preparation of TD = 30 ms before the TrueFISP readout. Measurements were performed in volunteers (n = 4) and in a pig model of chronic ischemia (n = 1).
  
  
  RESULTS
  In phantoms, the signal intensity was linear with contrast concentration up to 0.9 mmol/kg Gd-DTPA. MR images obtained with SR-Trufi had a good image quality and high spatial resolution of 2.1 mm x 2.1 mm. Differences of the contrast agent's kinetics between a subendocardial perfusion deficit and neighboring myocardium were well visible on both MR images and signal-time curves derived from the region-of-interest analysis.
  
  
  CONCLUSIONS
  SR-Trufi appears to be an interesting new technique for the assessment of myocardial microcirculation using dedicated cardiovascular MR systems.
authors: Klinik und Poliklinik für Radiologie, Johannes-Gutenberg-Universität, Mainz. wolfgang.schreiber@radiologie.klinik.uni-mainz.de
authors: W G
authors: WG
authors: Schreiber
authors: M
authors: M
authors: Schmitt
authors: P
authors: P
authors: Kalden
authors: G
authors: G
authors: Horstick
authors: T
authors: T
authors: Gumbrich
authors: S
authors: S
authors: Petersen
authors: O
authors: O
authors: Mohrs
authors: K F
authors: KF
authors: Kreitner
authors: T
authors: T
authors: Voigtländer
authors: M
authors: M
authors: Thelen
mesh_terms: D000328:Adult; D000818:Animals; D003287:Contrast Media; D003326:Coronary Circulation; D004562:Electrocardiography; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008833:Microcirculation; D017202:Myocardial Ischemia / Q000175:diagnosis; D019047:Phantoms, Imaging; D010865:Pilot Projects; D013552:Swine; D013997:Time Factors
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA