title: Erythrocyte, plasma, and serum antioxidant activities in untreated toxic multinodular goiter patients.
abstract: Erythrocyte, plasma, and serum antioxidant activities were studied in patients with newly diagnosed and untreated toxic multinodular hyperthyroid goiter and compared to healthy control subjects. Erythrocyte antioxidant enzyme activities, glutathione, malondialdehyde, and ceruloplasmin levels were significantly increased, whereas serum vitamin E, plasma vitamin C, and selenium levels were decreased in hyperthyroid patients compared to control subjects. The findings show that untreated toxic multinodular goiter causes profound alterations in components of the antioxidant system in erythrocytes indicative of increased oxidative stress. Taken together, these data suggest that hyperthyroid patients may benefit from dietary supplements of antioxidants.
authors: Department of Biochemistry, Akdeniz University, Faculty of Medicine, Antalya, Turkey. yakup@med.akdeniz.edu.tr
authors: Y
authors: Y
authors: Alicigüzel
authors: S N
authors: SN
authors: Ozdem
authors: S S
authors: SS
authors: Ozdem
authors: U
authors: U
authors: Karayalçin
authors: S L
authors: SL
authors: Siedlak
authors: G
authors: G
authors: Perry
authors: M A
authors: MA
authors: Smith
mesh_terms: D000328:Adult; D000975:Antioxidants / Q000378:metabolism*; D001205:Ascorbic Acid / Q000097:blood; D002570:Ceruloplasmin / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006044:Goiter, Nodular / Q000097:blood* / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D018384:Oxidative Stress; D011863:Radioimmunoassay; D012643:Selenium / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D014284:Triiodothyronine; D014810:Vitamin E; D008315:Malondialdehyde; D013972:Thyrotropin; D005979:Glutathione Peroxidase; D002570:Ceruloplasmin; D005978:Glutathione; D012643:Selenium; D001205:Ascorbic Acid; D013974:Thyroxine