Effect of protease inhibitors combined with standard antiretroviral therapy on linear growth and weight gain in human immunodeficiency virus type 1-infected children.
Children with HIV-1 infection and poor growth have a significant increase in the risk of death. We studied the effects of protease inhibitors on the height and weight of 27 HIV-1-infected children and found that in our small pilot study, protease inhibitor therapy had a positive effect on the heights of HIV-1-infected children. Accelerated height velocity was sustained for at least 18 to 20 months.
Dreimane
D
D
Department of Pediatrics, Mattel Children's Hospital at UCLA, Los Angeles, CA, USA. ddreiman@texas.net
Nielsen
K
K
Deveikis
A
A
Bryson
Y J
YJ
Geffner
M E
ME
D000293:Adolescent; D019380:Anti-HIV Agents / Q000627:therapeutic use; D001827:Body Height / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006130:Growth Disorders / Q000209:etiology / Q000517:prevention & control*; D015658:HIV Infections / Q000150:complications / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007223:Infant; D008297:Male; D010865:Pilot Projects; D011480:Protease Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D012189:Retrospective Studies; D019562:Viral Load
D019380:Anti-HIV Agents; D011480:Protease Inhibitors