title: Significance of lymphoglandular bodies in bone marrow aspiration smears.
abstract: The presence of lymphoglandular bodies (LGB) or Söderström bodies is often stated to be a feature of lymphoid processes. In our experience, LGB are typically identified in B-cell processes but not in T-cell lymphomas or myeloid leukemias. We reviewed 136 bone marrow aspirate smears. The number of LGB per five high-power fields was counted, and median counts for B-cell processes, non-B-cell processes, myeloid leukemias, and T-cell malignancies were obtained and compared by the Wilcoxon rank sum test. Bone marrow aspirate smears involved with B-cell malignancies contained a median of 30 (range, 1-250) LGB per five high-power fields. Compared to myeloid leukemias (median, 11; range, 1-253) and T-cell malignancies (median, 7; range, 0-41), the differences were statistically significant (P < 0.001 and P = 0.01, respectively). While lymphoglandular bodies can be seen in a variety of malignant hematopoietic and nonhematopoietic disorders, they are found in significantly greater numbers in B-cell malignancies.
authors: Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
authors: R C
authors: RC
authors: Stern
authors: K
authors: K
authors: Liu
authors: R K
authors: RK
authors: Dodge
authors: K S
authors: KS
authors: Elenitoba-Johnson
authors: L J
authors: LJ
authors: Layfield
mesh_terms: D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology*; D001856:Bone Marrow Examination / Q000379:methods; D003593:Cytoplasm / Q000473:pathology*; D006801:Humans; D015458:Leukemia, T-Cell / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000473:pathology