title: Analysis of the structure-anticancer activity relationship in a set of Schiff bases of macrocyclic 2,6-bis(2- and 4-formylaryloxymethyl)pyridines.
abstract: Quantitative estimation of the structure-anticancer activity relationship in a series of macrocyclic Schiff bases of 2,6-bis(formylaryloxymethyl)pyridines was carried out by the topological approach. Correlation equations describing the relationship between the anticancer activity and structural parameters of the molecules studied and descriptors characterizing their structure were obtained on the basis of in vitro screening data. The influence of structure of the investigated substances as reflected by the parameters studied on the anticancer activity, was established.
authors: Odessa I.I. Mechnikov State University, Dvoryanskaya 2, Ukraine. victor@farlep.net
authors: V E
authors: VE
authors: Kuz'min
authors: V P
authors: VP
authors: Lozitsky
authors: G L
authors: GL
authors: Kamalov
authors: R N
authors: RN
authors: Lozitskaya
authors: A I
authors: AI
authors: Zheltvay
authors: A S
authors: AS
authors: Fedtchouk
authors: D N
authors: DN
authors: Kryzhanovsky
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D012545:Schiff Bases / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D011725:Pyridines; D012545:Schiff Bases