Itk/Emt: a link between T cell antigen receptor-mediated Ca2+ events and cytoskeletal reorganization.
Itk/Emt, a tec family tyrosine kinase, is important for T-cell development and activation through the antigen receptor. Here, we review data suggesting that Itk/Emt is involved in the generation of critical second messengers (Ca(2+), PKC) whose duration it modulates by regulation of cytoskeletal reorganization. We propose that Itk/Emt constitutes an important link between these critical signaling events.
Tsoukas
C D
CD
Department of Biology and the Molecular Biology Institute, San Diego State University, CA 92182, USA. ctsoukas@sunstroke.sdsu.edu
Grasis
J A
JA
Ching
K A
KA
Kawakami
Y
Y
Kawakami
T
T
D000818:Animals; D020013:Calcium Signaling; D003599:Cytoskeleton / Q000201:enzymology* / Q000276:immunology*; D004789:Enzyme Activation / Q000276:immunology; D006801:Humans; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D013601:T-Lymphocytes / Q000201:enzymology / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; C080813:emt protein-tyrosine kinase