Metabolism and distribution of [2,3-(14)C]acrolein in lactating goats.
The metabolism and distribution of [2,3-(14)C]acrolein were studied in a lactating goat orally administered 0.82 mg/kg of body weight/day for 5 days. Milk, urine, feces, and expired air were collected. The goat was killed 12 h after the last dose, and edible tissues were collected. The nature of the radioactive residues was determined in milk and tissues. All of the identified metabolites were the result of the incorporation of acrolein into the normal, natural products of intermediary metabolism. There was evidence that the three-carbon unit of acrolein was incorporated intact into glucose, and subsequently lactose, and into glycerol. In the case of other natural products, the incorporation of radioactivity appeared to result from the metabolism of acrolein to smaller molecules followed by incorporation of these metabolites into the normal biosynthetic pathways.
Sharp
D E
DE
Covance Laboratories Inc., P.O. Box 7545, Madison, WI 53707, USA.
Berge
M A
MA
Paust
D E
DE
Talaat
R E
RE
Wilkes
L C
LC
Servatius
L J
LJ
Loftus
M L
ML
Caravello
H E
HE
Parent
R A
RA
D000171:Acrolein / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000818:Animals; D001711:Biotransformation; D001944:Breath Tests; D002250:Carbon Radioisotopes; D005243:Feces / Q000737:chemistry; D005260:Female; D006041:Goats; D007774:Lactation / Q000502:physiology*; D008892:Milk / Q000737:chemistry; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D000171:Acrolein