title: [The effect of a high dose bovine herpes virus 1 marker vaccine in pregnant heifers: virological, bacteriological, immunological, and pathological findings].
abstract: To determine a possible relationship between the compulsory vaccination against bovine herpesvirus 1 (BHV1) and cattle wasting disease, the effects of BHV1 vaccination on heifers were investigated. Twenty heifers in the third trimester of pregnancy were randomly allotted to a vaccine and a control group. The vaccine group was vaccinated twice with a 50-fold dose of BHV1 vaccine and the control group was inoculated with the diluent. The experiment was performed double blind. After vaccination, the cows were examined daily and condition scores were determined weekly. Blood, milk, and faeces samples were collected weekly for virological, bacteriological, and immunological investigation. The heifers were euthanized either 9 or 13 weeks after the first inoculation and pathological, virological, and bacteriological examination was performed. No differences were detected between the vaccine group and the control group. No concurrent infections were detected and there were no indications of immunosuppression after vaccination. No relationship between the BHV1 vaccination and wasting disease in cattle was detected.
authors: Institut voor Dierhouderij en Diergezondheid, Postbus 65 8200 AB Lelystad. c.j.m.bruschke@id.wag-ur.nl
authors: C J
authors: CJ
authors: Bruschke
authors: E M
authors: EM
authors: Kamp
authors: W
authors: W
authors: Boersma
authors: N
authors: N
authors: Stockhofe-Zurwieden
authors: A
authors: A
authors: Bouma
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000209:etiology*; D004311:Double-Blind Method; D005243:Feces / Q000382:microbiology / Q000821:virology; D005260:Female; D007242:Herpesvirus 1, Bovine / Q000276:immunology* / Q000472:pathogenicity; D007165:Immunosuppression Therapy / Q000662:veterinary; D008892:Milk / Q000276:immunology / Q000382:microbiology / Q000821:virology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology / Q000662:veterinary*; D013997:Time Factors; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary; D022581:Vaccines, Marker / Q000008:administration & dosage / Q000009:adverse effects; D014765:Viral Vaccines / Q000008:administration & dosage / Q000009:adverse effects*; D019282:Wasting Syndrome / Q000209:etiology / Q000662:veterinary*
chemical_list: D022581:Vaccines, Marker; D014765:Viral Vaccines