Decreased cytotoxicity and increased antimitotic activity of proline analogue of chlorambucil as a prodrug in breast cancer MCF-7 cells.
Bielawska
A
A
Department of Medicinal Chemistry and Drug Technology, Medical Academy of Białystok, 2 Mickiewicza Str., 15-230 Białystok, Poland.
Chrzanowski
K
K
Bielawski
K
K
Pałka
J
J
D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000473:pathology; D002699:Chlorambucil / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis; D004150:Dipeptidases / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008938:Mitosis / Q000187:drug effects*; D011355:Prodrugs / Q000378:metabolism / Q000494:pharmacology*; D011392:Proline / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D018906:Antineoplastic Agents, Alkylating; D011355:Prodrugs; D002699:Chlorambucil; D004247:DNA; D011392:Proline; D004150:Dipeptidases; C022449:proline dipeptidase