Lessons and questions from the structure of the Spo0A activation domain.
The carboxy-terminal domain of Spo0A in Bacillus subtilis is one of the few response regulator activation domains for which the structure is known. Here, we discuss some of the mutational data and biological roles of Spo0A in light of its structure.
Seredick
S
S
Department of Microbiology and Immunology, University of British Columbia, Vancouver, Canada.
Spiegelman
G B
GB
D001412:Bacillus subtilis / Q000235:genetics* / Q000378:metabolism; D001426:Bacterial Proteins / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D009154:Mutation; D011401:Promoter Regions, Genetic; D017434:Protein Structure, Tertiary; D012808:Sigma Factor / Q000378:metabolism; D014157:Transcription Factors / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D012808:Sigma Factor; C080950:Spo0A protein, Bacillus subtilis; D014157:Transcription Factors; C063505:RNA polymerase sigma A; D012321:DNA-Directed RNA Polymerases