title: Lipid and fatty acid composition of canine lipoproteins.
abstract: Lipid classes and their fatty acids were studied in the major lipoprotein fractions from canine, in comparison with human, plasma. In dogs, high-density-lipoprotein (HDL), the main carrier of plasma phospholipid (PL), cholesterol ester (CE) and free cholesterol, was the most abundant lipoprotein, followed by low and very-low density lipoproteins (LDL and VLDL). Notably, LDL and VLDL contributed similarly to the total dog plasma triacylglycerol (TG). The PL composition was similar in all three lipoproteins, dominated by phosphatidylcholine (PC). Even though the content and composition of lipids within and among lipoproteins differed markedly between dog and man, the total amount of circulating lipid was similar. All canine lipoproteins were relatively richer than those from humans in long-chain (C20-C22) n-6 and n-3 polyunsaturated fatty acids (PUFA) but had comparable proportions of total saturated and monoenoic fatty acids, with 18:2n-6 being the main PUFA in both mammals. The fatty acid profile of canine and human lipoproteins differed because they had distinct proportions of their major lipids. There were more n-3 and n-6 long-chain PUFA in canine than in human plasma, because dogs had more HDL, their HDL had more PC and CE, and both these lipids were richer in such PUFA.
authors: Instituto de Investigaciones Bioquímicas de Bahía Blanca, Consejo Nacional de Investigaciones Científicas y Técnicas y Universidad Nacional Del Sur, CC 857, 8000, Bahía Blanca, Argentina. enmaldon@criba.edu.ar
authors: E N
authors: EN
authors: Maldonado
authors: J R
authors: JR
authors: Romero
authors: B
authors: B
authors: Ochoa
authors: M I
authors: MI
authors: Aveldaño
mesh_terms: D000818:Animals; D002788:Cholesterol Esters / Q000097:blood; D004285:Dogs / Q000097:blood*; D005227:Fatty Acids / Q000032:analysis; D015525:Fatty Acids, Omega-3 / Q000097:blood; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000097:blood; D006801:Humans; D008055:Lipids / Q000032:analysis; D008074:Lipoproteins / Q000097:blood / Q000737:chemistry*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D010713:Phosphatidylcholines / Q000097:blood
chemical_list: D002788:Cholesterol Esters; D005227:Fatty Acids; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D010713:Phosphatidylcholines