Mast cell modulation of immune responses to bacteria.
Mast cells are key elements of the immune system. These cells release a wide variety of pro-inflammatory mediators which are responsible for the pathophysiology of many allergic diseases. Recent studies, however, have shown that mast cells have the capacity to modulate the host's innate immune response to gram negative bacteria by their ability to phagocytose bacteria, process and present bacterial antigens to T cells and recruit phagocytic help through the release of physiological amounts of pro-inflammatory mediators. Here, current knowledge of mast cell responses to gram negative bacteria and molecular mechanisms associated with mast cell bacteria interaction is reviewed.
Malaviya
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R
Department of Allergy & Inflammatory Diseases, Parker Hughes Institute, St Paul, MN 55113, USA. rmalaviya2@ih.org
Abraham
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D000081:Acetamides / Q000494:pharmacology; D018829:Adhesins, Bacterial / Q000276:immunology; D018830:Adhesins, Escherichia coli; D000485:Allergens / Q000276:immunology; D000818:Animals; D017951:Antigen Presentation; D000942:Antigens, Bacterial / Q000276:immunology; D015703:Antigens, CD / Q000276:immunology; D001419:Bacteria / Q000276:immunology*; D001424:Bacterial Infections / Q000276:immunology*; D000071178:CD48 Antigen; D036781:Fimbriae Proteins; D006090:Gram-Negative Bacteria / Q000276:immunology; D016905:Gram-Negative Bacterial Infections / Q000276:immunology; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D015289:Leukotrienes / Q000378:metabolism; D016859:Lipoxygenase Inhibitors / Q000494:pharmacology; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D010587:Phagocytosis; D010647:Phenyl Ethers; D017455:Receptors, IgE / Q000276:immunology; D015398:Signal Transduction; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000081:Acetamides; D018829:Adhesins, Bacterial; D018830:Adhesins, Escherichia coli; D000485:Allergens; D000942:Antigens, Bacterial; D015703:Antigens, CD; D000071178:CD48 Antigen; D018836:Inflammation Mediators; D015289:Leukotrienes; D016859:Lipoxygenase Inhibitors; D010647:Phenyl Ethers; D017455:Receptors, IgE; D014409:Tumor Necrosis Factor-alpha; C058769:fimH protein, E coli; C068663:N-hydroxy-N-(1-(4-(phenylmethoxy)phenyl)ethyl)-acetamide; D036781:Fimbriae Proteins