Practical injection-rate CT perfusion imaging: deconvolution-derived hemodynamics in a case of stroke.
Previously reported methods of dynamic, contrast-enhanced, CT perfusion imaging in acute stroke have been promising but substantially limited by their dependence on very rapid rates of injection (typically 10-20 ml/s in an arm vein). Newly available deconvolution software permits the use of lower rates of injection (e. g., 3-4 ml/s), and rapidly provides maps of cerebral blood flow, cerebral blood volume and mean transit time. We report the potential of CT perfusion imaging performed with an injection rate of 4 ml/s to provide information on the extent of hemodynamic abnormality, and to help distinguish viable from nonviable ischemic tissue. The slower injection rates permitted by deconvolution analysis substantially enhance the practicality of CT perfusion imaging for studying stroke.
Eastwood
J D
JD
Department of Radiology, Duke University Medical Center, Durham, NC 27710, USA. eastw004@mc.duke.edu
Provenzale
J M
JM
Hurwitz
L M
LM
Lee
T Y
TY
D001921:Brain / Q000098:blood supply*; D003287:Contrast Media / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D006439:Hemodynamics; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D020521:Stroke / Q000473:pathology*; D014057:Tomography, X-Ray Computed / Q000379:methods*
D003287:Contrast Media