title: The library of p-nitrophenyl esters of oligopeptides as a model to study the anticancer drug-peptide conjugates activated during tumor angiogenesis.
abstract: An indexed library of oligopeptide p-nitrophenyl esters immobilized via methoxy-1,3,5-triazine scaffold on the cellulose support, was synthesized by the step by step procedure and by segment coupling, involving 2-chloro-4,6-dimethoxy-1,3,5-triazine as a condensing reagent. The substrate specificity towards homogenate supernatant of mouse lung cancer LL2 cells has been studied.
authors: Department of Bioorganic Chemistry, Center of Molecular and Macromolecular Studies, PAS, Łódź.
authors: R W
authors: RW
authors: Kinas
authors: A
authors: A
authors: Opolski
authors: B
authors: B
authors: Kolesińska
authors: Z J
authors: ZJ
authors: Kamiński
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D001711:Biotransformation; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy; D020650:Combinatorial Chemistry Techniques; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000378:metabolism; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000627:therapeutic use; D019151:Peptide Library
chemical_list: D000970:Antineoplastic Agents; D009842:Oligopeptides; D019151:Peptide Library