title: Increased expression of VEGF following exercise training in patients with heart failure.
abstract: OBJECTIVE
  During the last decades several angiogenic factors have been characterized but so far it is unknown whether local muscle exercise training increases the expression of these factors in patients with moderate heart failure. Expression of the major putative angiogenic factor vascular endothelial growth factor (VEGF) at the level of messenger RNA (mRNA) and/or protein was therefore studied before and after 8 weeks of training in patient with chronic heart failure.
  
  
  METHODS
  VEGF mRNA and protein concentrations were determined in skeletal muscle biopsies before and after 8 weeks of one-legged knee extension training in patients with chronic heart failure (New York Heart Association II-III).
  
  
  RESULTS
  Exercise training increased the citrate synthase activity and peripheral exercise capacity by 46% and 36%, respectively, in parallel with a two-fold increase in VEGF at both the mRNA (P = 0.03) and protein (P = 0.02) levels
  
  
  CONCLUSIONS
  The increase in VEGF gene expression in response to exercise training indicates VEGF to be one possible mediator in exercise-induced angiogenesis and may therefore regulate an important and early step in adaptation to increased muscle activity in patient with chronic heart failure.
authors: Department of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden. Thomas.Gustafsson@fyfa.ki.se
authors: T
authors: T
authors: Gustafsson
authors: K
authors: K
authors: Bodin
authors: C
authors: C
authors: Sylvén
authors: A
authors: A
authors: Gordon
authors: R
authors: R
authors: Tyni-Lenné
authors: E
authors: E
authors: Jansson
mesh_terms: D000368:Aged; D002908:Chronic Disease; D002950:Citrate (si)-Synthase / Q000378:metabolism; D016228:Endothelial Growth Factors / Q000096:biosynthesis* / Q000235:genetics; D015444:Exercise; D005260:Female; D006333:Heart Failure / Q000201:enzymology / Q000378:metabolism* / Q000503:physiopathology*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008222:Lymphokines / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D018485:Muscle Fibers, Skeletal / Q000145:classification / Q000201:enzymology; D010732:Phosphofructokinase-1 / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D014938:Work Capacity Evaluation
chemical_list: D016228:Endothelial Growth Factors; D008222:Lymphokines; D012333:RNA, Messenger; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D007770:L-Lactate Dehydrogenase; D002950:Citrate (si)-Synthase; D010732:Phosphofructokinase-1