Genetic epidemiology. Giant cell arteritis and polymyalgia rheumatica.
Giant cell arteritis (GCA) (temporal arteritis) and polymyalgia rheumatica (PMR) are common, frequently related conditions in people generally over 50 years of age. Most studies have shown an association of GCA with HLA-DRB1 *04 alleles. As regards isolated PMR, however, the HLA class II genetic susceptibility varies from one population to another. Besides associations with HLA, tumor necrosis factor appears to influence susceptibility to both conditions. Genetic polymorphisms have also been considered to be important candidates as factors of susceptibility to GCA and PMR. In this regard, gene polymorphisms for ICAM-1 (intercellular adhesion molecule 1), RANTES (regulated upon activation, normal T cell expressed, and presumably secreted), and interleukin (IL)-1 receptor antagonist seem to play a role in the pathogenesis of GCA and PMR in some populations. However, additional studies are required to clarify the genetic influence on susceptibility to these conditions.
Gonzalez-Gay
M A
MA
Rheumatology Division, Hospital-Xeral Calde, Lugo, Spain. miguelaggay@hotmail.com
D000368:Aged; D018946:Chemokine CCL5 / Q000235:genetics; D005060:Europe / Q000453:epidemiology; D020022:Genetic Predisposition to Disease; D013700:Giant Cell Arteritis / Q000453:epidemiology / Q000235:genetics*; D006684:HLA-DR Antigens / Q000235:genetics; D059811:HLA-DRB1 Chains; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics; D053590:Interleukin 1 Receptor Antagonist Protein; D008875:Middle Aged; D009656:North America / Q000453:epidemiology; D011110:Polymorphism, Genetic; D011111:Polymyalgia Rheumatica / Q000453:epidemiology / Q000235:genetics*; D012795:Sialoglycoproteins / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D018946:Chemokine CCL5; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D012795:Sialoglycoproteins; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1