title: Search for potential angiotensin converting enzyme (ACE)-inhibitors from plants.
abstract: MeOH extracts, fractions and pure substances from Musanga cecropioides, Cecropia species and Crataegus oxyacantha /C. monogyna were screened by using an in vitro bio-assay based on the inhibition of Angiotensin Converting Enzyme (ACE), as measured from the enzymatic cleavage of the chromophore-fluorophore-labelled substrate dansyltriglycine into dansylglycine and diglycine. Phenolic acids showed no significant ACE-inhibition whereas flavonoids and proanthocyanidins demonstrated inhibitory activity at 0.33 mg/ml using this test system.
authors: Laboratoire de Pharmacognosie, Unité de Molecules d'Intérêt Biologique, Faculté de Pharmacie, Université de Bourgogne, Dijon, France. malacd@u-bourgogne.fr
authors: Lacaille-Dubois
authors: U
authors: U
authors: Franck
authors: H
authors: H
authors: Wagner
mesh_terms: D000806:Angiotensin-Converting Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D000872:Anthocyanins / Q000737:chemistry; D005419:Flavonoids / Q000737:chemistry; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D044945:Proanthocyanidins
chemical_list: D000806:Angiotensin-Converting Enzyme Inhibitors; D000872:Anthocyanins; D005419:Flavonoids; D010936:Plant Extracts; D044945:Proanthocyanidins; C013221:proanthocyanidin