title: Therapeutic potential of dietary phase 2 enzyme inducers in ameliorating diseases that have an underlying inflammatory component.
abstract: Many diseases associated with ageing have an underlying oxidative stress and accompanying inflammatory component, for example, Alzheimer's disease or atherosclerosis. Reviewed in this manuscript are: the role of oxidative stress in activating the transcription factor nuclear factor kappa B (NFkappaB), the role of NFkappaB in activating proinflammatory gene transcription, strong oxidants produced by cells, anti-oxidant defense systems, the central role of phase 2 enzymes in the anti-oxidant defense, dietary phase 2 enzyme inducers and evidence that dietary phase 2 enzymes decrease oxidative stress. It is likely that a diet containing phase 2 enzyme inducers may ameliorate or even prevent diseases that have a prominent inflammatory component to them. Research should be directed into the potential therapeutic effects of dietary phase 2 enzyme inducers in ameliorating diseases with an underlying oxidative stress and inflammatory component to them.
authors: Department of Anatomy & Cell Biology, The Cameco Multiple Sclerosis and Neuroscience Research Centre, College of Medicine, University of Saskatchewan, Saskatoon, Canada. juurlink@duke.usask.ca
authors: B H
authors: BH
authors: Juurlink
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D004790:Enzyme Induction / Q000502:physiology*; D005504:Food Analysis; D006801:Humans; D007249:Inflammation / Q000178:diet therapy* / Q000473:pathology; D016328:NF-kappa B / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology
chemical_list: D000975:Antioxidants; D016328:NF-kappa B