Theodore Cooper Lecture: Tissue angiotensin and pathobiology of vascular disease: a unifying hypothesis.
There is increasing evidence that direct pathobiological events in the vessel wall play an important role in vascular disease. An important mechanism involves the perturbation of the homeostatic balance between NO and reactive oxygen species. Increased reactive oxygen species can inactivate NO and produce peroxynitrite. Angiotensin II is a potent mediator of oxidative stress and stimulates the release of cytokines and the expression of leukocyte adhesion molecules that mediate vessel wall inflammation. Inflammatory cells release enzymes (including ACE) that generate angiotensin II. Thus, a local positive-feedback mechanism could be established in the vessel wall for oxidative stress, inflammation, and endothelial dysfunction. Angiotensin II also acts as a direct growth factor for vascular smooth muscle cells and can stimulate the local production of metalloproteinases and plasminogen activator inhibitor. Taken together, angiotensin II can promote vasoconstriction, inflammation, thrombosis, and vascular remodeling. In this article, we propose a model that unifies the interrelationship among cardiovascular risk factors, angiotensin II, and the pathobiological mechanisms contributing to cardiovascular disease. This model may also explain the beneficial effects of ACE inhibitors on cardiovascular events beyond blood pressure reduction.
Dzau
V J
VJ
Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. vdzau@bics.bwh.harvard.edu
D000804:Angiotensin II / Q000096:biosynthesis / Q000378:metabolism*; D002318:Cardiovascular Diseases / Q000378:metabolism* / Q000473:pathology*; D015815:Cell Adhesion Molecules / Q000378:metabolism; D002450:Cell Communication; D016207:Cytokines / Q000378:metabolism; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000473:pathology*; D004789:Enzyme Activation; D006706:Homeostasis; D006801:Humans; D007249:Inflammation; D008954:Models, Biological; D009569:Nitric Oxide / Q000378:metabolism; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D017382:Reactive Oxygen Species; D012307:Risk Factors
D015815:Cell Adhesion Molecules; D016207:Cytokines; D017382:Reactive Oxygen Species; D000804:Angiotensin II; D009569:Nitric Oxide; D007703:Peptidyl-Dipeptidase A