Oral contraception and ear disease: findings in a large cohort study.
A number of authors have suggested that oral contraceptives may increase the risk of certain ear diseases, especially otosclerosis and vestibular disorders, although the amount of published information on this topic is limited. We have analyzed the available data on ear disease in the Oxford-Family Planning Association contraceptive study that includes 17,032 women followed for periods of up to 26 years. No evidence of any adverse effect of oral contraceptives on ear disease was detected. A protective effect of oral contraceptives against wax in the ear has been described in the Royal College of General Practitioners oral contraception study. The amount of data available in the Oxford-Family Planning Association study was too small to permit confirmation or refutation of this finding.
Vessey
M
M
Unit of Health Care Epidemiology, University Department of Public Health, Institute of Health Sciences, Headington, Oxford OX3 7LF, UK. martin.vessey@dphpc.ox.ac.uk
Painter
R
R
D015331:Cohort Studies; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003638:Deafness / Q000453:epidemiology; D004427:Ear Diseases / Q000453:epidemiology*; D005260:Female; D006801:Humans; D010033:Otitis Media / Q000453:epidemiology; D012307:Risk Factors; D014012:Tinnitus / Q000453:epidemiology; D014717:Vertigo / Q000453:epidemiology
D003276:Contraceptives, Oral