title: Costs and outcomes of use of amitriptyline, citalopram and fluoxetine in major depression: exploratory study.
abstract: BACKGROUND
  The increasing cost of pharmaceuticals in the Czech Republic has led to the restriction on prescriptions of expensive new antidepressants. The aim of the study was to compare the costs and outcomes of using amitriptyline, citalopram and fluoxetine in the treatment of major depression.
  
  
  METHODS
  Ninety patients (69 women) with a mean age of 44.5 years (S.D. = 14.3) suffering from major depression were treated with amitriptyline (N = 31), citalopram (N = 29) and fluoxetine (N = 30). Direct medical costs and effectiveness (indicated by the number of hospitalization-free days) were assessed in a prospective, open, intent-to-treat study.
  
  
  RESULTS
  Neither cost nor effectiveness were significantly different among the treatment groups.
  
  
  CONCLUSIONS
  Amitriptyline treatment is not less expensive nor more effective than citalopram or fluoxetine therapies. There is no advantage in restricting patients from treatment with SSRIs, which have fewer adverse effects and a decreased risk of a lethal overdosage in comparison with tricyclic antidepressants.
authors: Department of Psychiatry, Charles University in Prague, Faculty of Medicine in Hradec Králové. hosak@lfhk.cuni.cz
authors: L
authors: L
authors: Hosák
authors: I
authors: I
authors: Tůma
authors: H
authors: H
authors: Hanus
authors: L
authors: L
authors: Straka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000191:economics / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000191:economics* / Q000627:therapeutic use; D015283:Citalopram / Q000191:economics / Q000627:therapeutic use; D018153:Czech Republic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000191:economics*; D016527:Drug Costs; D005260:Female; D005473:Fluoxetine / Q000191:economics / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents; D005473:Fluoxetine; D015283:Citalopram; D000639:Amitriptyline