Anti-genotoxicity of trans-anethole and eugenol in mice.
The naturally occurring flavouring agents trans-anethole and eugenol were evaluated for antigenotoxic effects in mice. The test doses of trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg weight) were administered by gavage 2 and 20 h before the genotoxins were injected intraperitoneally. Anti-genotoxic effects were assessed in the mouse bone marrow micronucleus test. Pretreatment with trans-anethole and eugenol led to significant antigenotoxic effects against cyclophosphamide (CPH), procarbazine (PCB), N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and urethane (URE). In addition, trans-anethole inhibited the genotoxicity of ethyl methane sulfonate (EMS). Both trans-anethole and eugenol exerted dose-related antigenotoxic effects against PCB and URE. There was no significant increase in genotoxicity when trans-anethole (40-400 mg/kg body weight) and eugenol (50-500 mg/kg body weight) were administered alone.
Abraham
S K
SK
School of Life Sciences, Jawaharlal Nehru University, -110067, New Delhi, India. asuresh51@hotmail.com
D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects / Q000648:ultrastructure; D005020:Ethyl Methanesulfonate / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D005054:Eugenol / Q000494:pharmacology*; D005421:Flavoring Agents / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000008:administration & dosage; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D011344:Procarbazine / Q000008:administration & dosage / Q000037:antagonists & inhibitors; D014520:Urethane / Q000008:administration & dosage / Q000037:antagonists & inhibitors
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D005421:Flavoring Agents; D009153:Mutagens; D008769:Methylnitronitrosoguanidine; D011344:Procarbazine; D014520:Urethane; D005054:Eugenol; D003520:Cyclophosphamide; D005020:Ethyl Methanesulfonate; C006578:anethole