Novel periodontal drug delivery system for treatment of periodontitis.
A conceptually novel periodontal drug delivery system (DDS) is described that is intended for treatment of microbial infections associated with periodontitis. The DDS is a composite wafer with surface layers possessing adhesive properties, while the bulk layer consists of antimicrobial agents, biodegradable polymers, and matrix polymers. The wafers contain poly(lactic-co-glycolic acid) as the main bioerodible component used in the bulk layer and ethyl cellulose applied as a matrix polymer enabling diffusion-controlled release. Starch and other polymers in combination with AgNO(3) serve as coatings adhesive to the teeth. In vitro experiments demonstrate that the wafers are capable of zero-order release of antimicrobial agents such as silver nitrate, benzylpenicillin, and tetracycline, for over 4 weeks.
Bromberg
L E
LE
Periodontix, Inc., 313 Pleasant Street, Watertown, MA 02472, USA. cpbrolev@yahoo.com
Buxton
D K
DK
Friden
P M
PM
D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002482:Cellulose / Q000031:analogs & derivatives; D003432:Cross-Linking Reagents; D016503:Drug Delivery Systems; D005079:Excipients; D005881:Gingiva / Q000378:metabolism*; D019344:Lactic Acid; D008855:Microscopy, Electron, Scanning; D010400:Penicillin G / Q000008:administration & dosage / Q000627:therapeutic use; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D010518:Periodontitis / Q000188:drug therapy*; D011092:Polyethylene Glycols; D011100:Polyglycolic Acid; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011108:Polymers; D012835:Silver Nitrate / Q000008:administration & dosage / Q000737:chemistry; D013752:Tetracycline / Q000008:administration & dosage / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003432:Cross-Linking Reagents; D005079:Excipients; D010406:Penicillins; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011100:Polyglycolic Acid; D019344:Lactic Acid; D011092:Polyethylene Glycols; C013517:ethyl cellulose; D002482:Cellulose; D012835:Silver Nitrate; D013752:Tetracycline; D010400:Penicillin G