title: Spray-drying as a method for microparticulate controlled release systems preparation: advantages and limits. I. Water-soluble drugs.
abstract: Spray-drying was used for the preparation of paracetamol/eudragit RS or RL or ethylcellulose microspheres to verify the possibility of their use in controlled-release solid-dosage forms formulation and try to determine advantages and limits of the technique of such use. Microspheres were first characterized by scanning electron microscopy, differential scanning calorimetry, x-ray diffractometry, and in vitro dissolution studies and then used for the preparation of tablets. During this step, the compressibility of the spray-dried powders was also evaluated. In vitro dissolution studies were performed also on the tablets and their release control was accessed. Although powders were unable to slow down drug release, tablets obtained from microsphere compression showed a good capability of controlling paracetamol release when eudragit RS or ethylcellulose was used, even at low polymer amounts.
authors: Università di Camerino, Dipartimento di Scienze Chimiche, Via S. Agostino 1, 62032 Camerino, MC, Italy.
authors: G F
authors: GF
authors: Palmieri
authors: G
authors: G
authors: Bonacucina
authors: P
authors: P
authors: Di Martino
authors: S
authors: S
authors: Martelli
mesh_terms: D000082:Acetaminophen; D000180:Acrylic Resins; D018712:Analgesics, Non-Narcotic; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical / Q000379:methods*; D003692:Delayed-Action Preparations; D005782:Gels; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D011109:Polymethacrylic Acids; D012995:Solubility; D013607:Tablets; D014961:X-Ray Diffraction
chemical_list: D000180:Acrylic Resins; D018712:Analgesics, Non-Narcotic; D003692:Delayed-Action Preparations; D005782:Gels; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D000082:Acetaminophen