Synthesis of new fused pyrimidines by isocyanate and isothiocyanate.
o-Aminonitrile or o-aminoester compounds were cyclized to fused pyrimidines by reacting with ethyl iso(thio)cyanatoacetate in pyridine, and then were methylated, halogenated and subsequently displaced by the amines studied.
Chowdhury
A Z
AZ
Environmental Chemistry Division, National Institute for Environmental Studies, Tsukuba, Ibaraki, Japan. a.chowdhury@nies.go.jp
Shibata
Y
Y
D000588:Amines / Q000138:chemical synthesis / Q000737:chemistry; D003500:Cyclization; D017953:Isocyanates / Q000737:chemistry*; D017879:Isothiocyanates / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D011743:Pyrimidines / Q000138:chemical synthesis*
D000588:Amines; D017953:Isocyanates; D017879:Isothiocyanates; D011743:Pyrimidines