title: Clofazimine enteropathy in a pediatric bone marrow transplant recipient.
abstract: Clofazimine, previously used in the treatment of leprosy, is now used for treatment of Mycobacterium avium complex infection in patients with acquired immune deficiency syndrome, dermatologic disorders, and graft-versus-host disease. An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease. Clofazimine enteropathy caused by crystal deposition can be life-threatening.
authors: Department of Pathology, Division of Gastroenterology, Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15513, USA.
authors: M
authors: M
authors: Parizhskaya
authors: N N
authors: NN
authors: Youssef
authors: C
authors: C
authors: Di Lorenzo
authors: R K
authors: RK
authors: Goyal
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D002991:Clofazimine / Q000009:adverse effects*; D004378:Duodenal Diseases / Q000139:chemically induced* / Q000473:pathology; D004386:Duodenum / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002991:Clofazimine