title: A follow-up linkage study supports evidence for a bipolar affective disorder locus on chromosome 21q22.
abstract: Evidence for linkage between bipolar affective disorder (BP) and 21q22 was first reported by our group in a single large pedigree with a lod score of 3.41 with the PFKL locus. In a subsequent study, with denser marker coverage in 40 multiplex BP pedigrees, we reported supporting evidence with a two-point lod score of 2.76 at the D21S1260 locus, about 6 cM proximal to PFKL. For cost-efficiency, the individuals genotyped in that study comprised a subset of our large pedigree sample. To augment our previous analysis, we now report a follow-up study including a larger sample set with an additional 331 typed individuals from the original 40 families, improved marker coverage, and an additional 16 pedigrees. The analysis of all 56 pedigrees (a total of 862 genotyped individuals vs. the 372 genotyped previously), the largest multigenerational BP pedigree sample reportedly analyzed to date, supports our previous results, with a two-point lod score of 3.56 with D21S1260. The 16 new pedigrees analyzed separately gave a maximum two-point lod score of 1.89 at D21S266, less than 1 cM proximal to D21S1260. Our results are consistent with a putative BP locus on 21q22.
authors: Columbia Genome Center, Columbia University, New York, New York, USA.
authors: J
authors: J
authors: Liu
authors: S H
authors: SH
authors: Juo
authors: J D
authors: JD
authors: Terwilliger
authors: A
authors: A
authors: Grunn
authors: X
authors: X
authors: Tong
authors: M
authors: M
authors: Brito
authors: J E
authors: JE
authors: Loth
authors: K
authors: K
authors: Kanyas
authors: B
authors: B
authors: Lerer
authors: J
authors: J
authors: Endicott
authors: G
authors: G
authors: Penchaszadeh
authors: T C
authors: TC
authors: Gilliam
authors: M
authors: M
authors: Baron
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002891:Chromosomes, Human, Pair 21; D005260:Female; D005500:Follow-Up Studies; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008126:Lod Score; D008297:Male; D010375:Pedigree
chemical_list: D005819:Genetic Markers