title: An improved method for the palladium-catalyzed amination of aryl iodides.
abstract: Aryl iodides are coupled with amines to give the corresponding arylamines in high yield in the presence of palladium, a suitable ligand, and NaOt-Bu. Functionalized aryl iodides give good yields of the corresponding arylamines when Cs(2)CO(3) is substituted as the base.
authors: Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
authors: M H
authors: MH
authors: Ali
authors: S L
authors: SL
authors: Buchwald
mesh_terms: D000588:Amines / Q000138:chemical synthesis*; D002384:Catalysis; D006841:Hydrocarbons, Aromatic / Q000737:chemistry*; D007454:Iodides / Q000737:chemistry; D008024:Ligands; D010165:Palladium
chemical_list: D000588:Amines; D006841:Hydrocarbons, Aromatic; D007454:Iodides; D008024:Ligands; D010165:Palladium