title: Lysosomal phospholipase A1 in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas' disease.
abstract: We found that, as in African trypanosomes, endogenous phospholipase A(1) (Plase A(1)) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A(1) was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A(1) emerges as a target to block pathogenesis in trypanosomal infections.
authors: Department of Microbiology, University of Buenos Aires (UBA) School of Medicine, Paraguay 2155, piso 13, (RA-2111) Buenos Aires, Argentina.
authors: M
authors: M
authors: Wainszelbaum
authors: E
authors: E
authors: Isola
authors: S
authors: S
authors: Wilkowsky
authors: J J
authors: JJ
authors: Cannata
authors: J
authors: J
authors: Florin-Christensen
authors: M
authors: M
authors: Florin-Christensen
mesh_terms: D000818:Animals; D002384:Catalysis; D014355:Chagas Disease / Q000378:metabolism / Q000469:parasitology*; D006801:Humans; D008247:Lysosomes / Q000201:enzymology*; D010741:Phospholipases A / Q000302:isolation & purification / Q000378:metabolism* / Q000502:physiology; D054466:Phospholipases A1; D010743:Phospholipids / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000201:enzymology* / Q000472:pathogenicity
chemical_list: D010743:Phospholipids; D010741:Phospholipases A; D054466:Phospholipases A1