title: Synthesis of 2-substituted trifluoromethylquinolines for the evaluation of leishmanicidal activity.
abstract: The synthesis of 2-substituted-trifluoromethylquinolines from aniline, trifluoromethylanilines, 3-aminoquinoline and trifluoromethylquinaldines is reported. In vitro antileishmanial evaluation of 2-alkyl, 2-alkenyl and 2-epoxypropyl-trifluoromethylquinolines is presented.
authors: Laboratoire de Chimie organique, Faculté de Pharmacie, UPRES-A CNRS 8076, Université de Paris-Sud, Clément, Châtenay-Malabry, France.
authors: J
authors: J
authors: Dade
authors: O
authors: O
authors: Provot
authors: H
authors: H
authors: Moskowitz
authors: J
authors: J
authors: Mayrargue
authors: E
authors: E
authors: Prina
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D007891:Leishmania / Q000187:drug effects*; D007893:Leishmania donovani / Q000187:drug effects; D018314:Leishmania infantum / Q000187:drug effects; D007894:Leishmania mexicana / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000981:Antiprotozoal Agents; D007202:Indicators and Reagents; D011804:Quinolines