Serum ceruloplasmin in melanoma patients.
We have studied the serum ceruloplasmin levels as a possible diagnostic factor or marker for detection, diagnosis and follow-up of patients with melanoma. Ceruloplasmin concentration was determined in 64 melanoma patients (MP) and in 37 healthy persons (HP) by nephelometry. We found a mean value of 29.85 +/- 5.47 mg/dl in MP and 26.10 +/- 5.22 mg/dl in HP. A significant increase in the levels of serum ceruloplasmin was observed in MP in comparison to those in HP (P = 0.0011). In order to check whether this test could discriminate between MP and HP, a complete statistical Receiver Operating Characteristic (ROC) curve analysis was performed. The cut-off value was 25.10 mg/dl. The area under the curve was 0.689. According to these results, the test could discriminate adequately between the two groups.
Ros-Bullón
M R
MR
Division of Clinical Analysis, H.U.V. Arrixaca, Spain.
Sánchez-Pedreño
P
P
Martínez-Liarte
J H
JH
D019540:Area Under Curve; D014408:Biomarkers, Tumor / Q000097:blood*; D002570:Ceruloplasmin / Q000032:analysis*; D006801:Humans; D008545:Melanoma / Q000097:blood* / Q000175:diagnosis; D009363:Neoplasm Proteins / Q000097:blood*; D009391:Nephelometry and Turbidimetry; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity; D012878:Skin Neoplasms / Q000097:blood* / Q000175:diagnosis
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D002570:Ceruloplasmin