Apoptosis in oncology.
Apoptosis is a complex process involving a large array of genes and mutation of any of these genes may lead to malignancy formation. Re-acquirement of FasL by tumor cells may enable them to evade the surveillance of immune system and thus contributes to the growth of tumor. Apart from traditional therapies, inducing apoptosis of tumor cell by new methods employing death receptor ligands and making use of Fas counterattack is also being developed.
Fan
X Q
XQ
International Joint Cancer Institute, The Second Military Medical University, Shanghai, China.
Guo
Y J
YJ
D000818:Animals; D017209:Apoptosis / Q000187:drug effects / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008495:Medical Oncology / Q000639:trends*; D009369:Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000503:physiopathology; D015398:Signal Transduction / Q000235:genetics; D019014:fas Receptor / Q000235:genetics
D019014:fas Receptor