A self-designing rule for clinical trials with arbitrary response variables.
For testing both one-sided and two-sided hypotheses concerning several treatment arms in group sequentially performed clinical trials with arbitrary outcome variables, a general method is considered that allows one to completely self-design a study. All information available prior to a stage is used for estimating the sample size and the weight for the next step. In "using up" the variance, the test statistic is built in a bounded finite but random number of stages to test just once the rejection of the null hypothesis. Control Clin Trials 2001;22:111-116
Hartung
J
J
Department of Statistics, University of Dortmund, D-44221 Dortmund, Germany. Hartung@statistik.unidortmund.de
D002986:Clinical Trials as Topic / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D018709:Statistics, Nonparametric