Laminin-5 as a predictor of invasiveness in cancer in situ lesions of the larynx.
Squamous epithelial cancer in situ (CIS) of the upper aerodigestive tract is a histopathologically well-defined condition. There is yet no reliable way to predict whether a CIS lesion will progress to invasive cancer, remain stable or regress. In the search for markers able to foretell clinical outcome, we performed immunohistochemical staining with a polyclonal antibody against recombinant gamma 2 chain of laminin-5 in 33 laryngeal CIS lesions. All six CIS lesions which progressed to invasive cancer, within a follow-up time of 5 years, were laminin-5 positive (100%), whereas only 10 out of 27 lesions which did not progress were positive (37%) (p < 0.01). Our data showed that a positive laminin-5 laryngeal CIS lesion indicates a high risk for progression to invasive cancer.
Nordemar
S
S
Department of Oto-Rhino-Laryngology, Karolinska Hospital, S-17176 Stockholm, Sweden. sun@ent.ks.se
Kronenwett
U
U
Auer
G
G
Högmo
A
A
Lindholm
J
J
Edström
S
S
Tryggvasson
K
K
Linder
S
S
Munck-Wikland
E
E
D000328:Adult; D000368:Aged; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D002278:Carcinoma in Situ / Q000737:chemistry / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology*; D019090:Case Management; D015815:Cell Adhesion Molecules / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D007822:Laryngeal Neoplasms / Q000737:chemistry / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000175:diagnosis*; D009363:Neoplasm Proteins / Q000032:analysis* / Q000276:immunology; D011379:Prognosis; D021122:Protein Subunits; D011817:Rabbits; D011993:Recombinant Fusion Proteins / Q000276:immunology; D012306:Risk; D000097794:Kalinin
D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D009363:Neoplasm Proteins; D021122:Protein Subunits; D011993:Recombinant Fusion Proteins; D000097794:Kalinin