Anti-inflammatory activity of compounds isolated from the aerial parts of Abrus precatorius (Fabaceae).
Two triterpenoid saponins 1 and 2 isolated from the aerial parts of Abrus precatorius and their acetates derivatives, 3 and 4 have been tested for anti-inflammatory activity using the croton oil ear model. All the compounds exhibited anti-inflammatory activity but the acetates showed greater inhibition than the parent compounds.
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Chemistry Department, University of Calabar, CRS, Nigeria.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D003436:Croton Oil; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D019685:Rosales; D012503:Saponins / Q000494:pharmacology* / Q000627:therapeutic use; D014315:Triterpenes / Q000494:pharmacology* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D012503:Saponins; D014315:Triterpenes; D003436:Croton Oil