Bone mineral density and breast cancer risk in postmenopausal women.
Two recent studies have shown a woman's bone mineral density (BMD) (a composite measure of exposure to many different factors throughout one's lifetime) predicts breast cancer. In a prospective cohort study, we examined whether hip BMD was associated with breast cancer risk among 8203 postmenopausal women. During an average follow-up of 3.7 years, 131 incident breast cancer cases (102 invasive) were identified. Cox proportional hazards models were used to obtain estimates of the relative risk of breast cancer. Our results demonstrate an increase in breast cancer risk among women with higher BMD. Independent of age, geographic area, and body mass index, relative to the lowest BMD quartile the risk of breast cancer (95% confidence interval) by increasing quartile was 1.9 (1.1, 3.2), 1.5 (0.8, 2.6), and 1.5 (0.8, 2.7), respectively. An examination of other factors important in determining BMD may help explain the positive association between BMD and breast cancer.
Buist
D S
DS
Center for Health Studies, Group Health Cooperative of Puget Sound, Seattle, WA 98101, USA.
LaCroix
A Z
AZ
Barlow
W E
WE
White
E
E
Weiss
N S
NS
D000368:Aged; D000369:Aged, 80 and over; D015992:Body Mass Index; D015519:Bone Density; D001943:Breast Neoplasms / Q000453:epidemiology / Q000209:etiology*; D002140:California / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007484:Iowa / Q000453:epidemiology; D008403:Mass Screening; D008875:Middle Aged; D009922:Oregon / Q000453:epidemiology; D015663:Osteoporosis, Postmenopausal / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology*; D011159:Population Surveillance; D017698:Postmenopause; D011237:Predictive Value of Tests; D016016:Proportional Hazards Models; D011446:Prospective Studies; D012307:Risk Factors; D018426:SEER Program; D014861:Washington / Q000453:epidemiology