Fumonisin B1 carry-over into milk in the isolated perfused bovine udder.
The mycotoxin fumonisin B1 (FB1) causes a variety of health problems in animals, while epidemiological evidence suggests it is linked to human esophageal cancer. We investigated the carry-over of FB1 into bovine milk using the isolated perfused bovine udder. Two mg of FB1 was injected into the perfusion blood of 3 udders, and milk and perfused serum levels were determined for 150 min. FB1 passed through the mammary barrier into the milk, but in such low concentrations as to present a negligible risk for consumers.
Spotti
M
M
University of Milan, Faculty of Veterinary Medicine, Institute of Veterinary Pharmacology and Toxicology, Milan, Italy.
Caloni
F
F
Fracchiolla
L
L
Pompa
G
G
Vigo
D
D
Maffeo
G
G
D000818:Animals; D002264:Carboxylic Acids / Q000493:pharmacokinetics*; D002274:Carcinogens, Environmental / Q000493:pharmacokinetics*; D002417:Cattle / Q000097:blood / Q000378:metabolism*; D005260:Female; D037341:Fumonisins; D006801:Humans; D066298:In Vitro Techniques; D007267:Injections / Q000662:veterinary; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008892:Milk / Q000378:metabolism*; D009183:Mycotoxins / Q000493:pharmacokinetics*; D010477:Perfusion / Q000662:veterinary
D002264:Carboxylic Acids; D002274:Carcinogens, Environmental; D037341:Fumonisins; D009183:Mycotoxins; C056933:fumonisin B1