Anti-proliferative effect of two lactic acid bacteria strains of human origin on the growth of a myeloma cell line.
OBJECTIVE
Twenty lactic acid bacteria strains were isolated from human faeces and tested by MTT assay for stimulation or inhibition of the proliferation of Vero and myeloma cells.


RESULTS
None of the strains significantly affected the proliferation of Vero cells. However, two isolates (HN1 and HA8) showed a strong inhibition of myeloma cell proliferation (16.7 and 5.0%, respectively) by MTT assay.


CONCLUSIONS
Both strains have an anti-proliferative effect on a tumoral cell line.


CONCLUSIONS
The beneficial effect of LAB cancer therapy has been linked to their ability for immunomodulation.
Zabala
A
A
Departamento de Nutrición y Bromatología III, Facultad de Veterinaria, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Martín
M R
MR
Haza
A I
AI
Fernández
L
L
Rodríguez
J M
JM
Morales
P
P
D000276:Adjuvants, Immunologic; D000328:Adult; D000818:Animals; D000970:Antineoplastic Agents; D002273:Carcinogens / Q000494:pharmacology; D002522:Chlorocebus aethiops; D016984:Enterococcus faecium / Q000502:physiology*; D005243:Feces / Q000382:microbiology; D006801:Humans; D007231:Infant, Newborn; D007422:Intestines / Q000382:microbiology; D007778:Lactobacillus / Q000235:genetics / Q000502:physiology*; D051379:Mice; D019936:Probiotics / Q000627:therapeutic use*; D014407:Tumor Cells, Cultured; D014709:Vero Cells
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D002273:Carcinogens