title: Mixed pituitary adenoma-gangliocytoma in a female albino rat.
abstract: A mixed intrasellar pituitary adenoma-gangliocytoma was found incidentally in an aged female Sprague-Dawley-derived rat. The animal was killed at the end of a 104-week carcinogenicity study. At necropsy, the pituitary fossa was occupied by a large, hemorrhagic nodule compressing and displacing the base of the brain. The lesion consisted of large areas of a prolactin-secreting adenoma surrounding a central island of gangliocytoma. In the latter, ganglion-like cells of varying size exhibited, occasionally, beta-tubulin and neurofilament protein immunoreactivity in their perikarya, while their cell processes expressed intense neurofilament immunoreactivity. Accompanying satellite cells in the neuropil immunostained for glial acidic and S-100 proteins. To the best of our knowledge, the presence of mixed pituitary adenoma-gangliocytoma has not been previously reported in rats.
authors: Novartis Pharma AG, Preclinical Safety, Toxicology/Pathology, WSH-2881.4.05, 4002 Basle, Switzerland. virgilio.pace@pharma.novartis.com
authors: V
authors: V
authors: Pace
authors: E
authors: E
authors: Perentes
mesh_terms: D000818:Animals; D005260:Female; D005729:Ganglioneuroma / Q000378:metabolism / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D018198:Mixed Tumor, Malignant / Q000378:metabolism / Q000473:pathology*; D016900:Neurofilament Proteins / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000378:metabolism / Q000473:pathology*; D015175:Prolactinoma / Q000378:metabolism / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012376:Rodent Diseases / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D009418:S100 Proteins / Q000378:metabolism; D014404:Tubulin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D016900:Neurofilament Proteins; D009418:S100 Proteins; D014404:Tubulin