Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development.
We have recently reported the preliminary characterisation of a novel EGF-related gene, Scube1 (signal peptide-CUB domain-EGF-related, gene 1), that is expressed prominently in the developing gonad, nervous system, somites, surface ectoderm and limb buds of the mouse. Here we describe the expression pattern of a closely related gene, Scube2 (also known as Cegp1), which maps to the distal region of mouse chromosome 7. Scube2 transcription is restricted to the embryonic neurectoderm but is also detectable in the adult heart, lung and testis.
Grimmond
S
S
MRC Mammalian Genetics Unit, Harwell, OX11 0RD, Didcot, UK.
Larder
R
R
Van Hateren
N
N
Siggers
P
P
Morse
S
S
Hacker
T
T
Arkell
R
R
Greenfield
A
A
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D015152:Blotting, Northern; D002135:Calcium-Binding Proteins; D004475:Ectoderm / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000096:biosynthesis*; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism; D009420:Nervous System / Q000196:embryology*; D012333:RNA, Messenger / Q000378:metabolism; D013737:Testis / Q000378:metabolism; D014018:Tissue Distribution; D014158:Transcription, Genetic
D048868:Adaptor Proteins, Signal Transducing; D002135:Calcium-Binding Proteins; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger; C432427:Scube2 protein, mouse; D004815:Epidermal Growth Factor