Human BTR1, a new bicarbonate transporter superfamily member and human AE4 from kidney.
We report the cloning, characterization, and chromosomal localization of two novel human members of the bicarbonate transporter superfamily, BTR1 (Bicarbonate Transporter Related protein-1) and AE4 (Anion Exchange protein 4). BTR1 is a novel mammalian protein. The BTR1 gene maps to chromosome 20p12 and encodes a 100 kDa protein predominantly expressed in the kidney, salivary glands, testis, thyroid glands, and trachea. The AE4 gene maps to chromosome 5q23-31 and encodes a 104 kDa protein expressed mainly in the kidney. Human AE4 shares 84% identity with the recently reported rabbit AE4, a sodium independent, Cl(-)/HCO(-)(3) exchanger located on the apical membrane of beta-intercalated kidney cells.
Parker
M D
MD
Department of Biochemistry, School of Medical Sciences, University of Bristol, University Walk, Bristol, BS8 1TD, United Kingdom.
Ourmozdi
E P
EP
Tanner
M J
MJ
D020816:Amino Acid Motifs / Q000235:genetics; D027321:Anion Transport Proteins; D017920:Antiporters / Q000235:genetics* / Q000378:metabolism; D001639:Bicarbonates / Q000378:metabolism; D002474:Cell-Free System; D027963:Chloride-Bicarbonate Antiporters; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D003001:Cloning, Molecular; D006031:Glycosylation; D006801:Humans; D016623:Ion Pumps / Q000235:genetics / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008969:Molecular Sequence Data; D005810:Multigene Family; D009928:Organ Specificity; D020161:Physical Chromosome Mapping; D014176:Protein Biosynthesis; D017386:Sequence Homology, Amino Acid; D027982:Sodium-Bicarbonate Symporters
D027321:Anion Transport Proteins; D017920:Antiporters; D001639:Bicarbonates; D027963:Chloride-Bicarbonate Antiporters; D016623:Ion Pumps; C425809:SLC4A11 protein, human; C440068:SLC4A9 protein, human; D027982:Sodium-Bicarbonate Symporters