title: Differential effect of Fyn tyrosine kinase deletion on offensive and defensive aggression.
abstract: Fyn tyrosine kinase is highly expressed in the limbic system and mice lacking Fyn tyrosine kinase showed increased fearfulness in a variety of tests for anxiety-related behaviors. To investigate the possible role of Fyn tyrosine kinase in aggression, we assessed the aggressive behaviors of the mice lacking the Fyn tyrosine kinase using the resident-intruder and restraint-induced target biting paradigms. The percentage of Fyn-deficient mice that attacked an inanimate target in a restraint tube was higher than that of the control mice. On the contrary, in the resident-intruder paradigm, the percentage of Fyn-deficient mice that attacked the intruder was lower and the Fyn-deficient mice showed a longer latency to attack an intruder. These results suggest a distinct role of Fyn tyrosine kinase in enhancing the offensive aggression and decreasing the defensive aggression. A possible influence of anxiety-phenotype of the Fyn-deficient mice on their abnormal aggressive behavior was discussed.
authors: Laboratory for Neurobiology of Emotion, Brain Science Institute, RIKEN, Hirosawa, Wako-shi, 351-0198, Saitama-ken, Japan.
authors: T
authors: T
authors: Miyakawa
authors: T
authors: T
authors: Yagi
authors: K
authors: K
authors: Takao
authors: H
authors: H
authors: Niki
mesh_terms: D000374:Aggression / Q000502:physiology* / Q000523:psychology; D000818:Animals; D001007:Anxiety / Q000235:genetics; D001522:Behavior, Animal / Q000502:physiology*; D017353:Gene Deletion; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010641:Phenotype; D011518:Proto-Oncogene Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D051076:Proto-Oncogene Proteins c-fyn
chemical_list: D011518:Proto-Oncogene Proteins; C494960:Fyn protein, mouse; D051076:Proto-Oncogene Proteins c-fyn