Caspases: more than just killers?
Proteases of the caspase family constitute the central executioners of apoptosis. Several recent observations suggest that caspases and apoptosis-regulatory molecules exert important functions beyond that of cell death, including the control of T-cell proliferation and cell-cycle progression. Here, Los and colleagues propose a model that directly connects cell suicide mechanisms to the regulation of cell-cycle progression.
Los
M
M
Dept of Immunology and Cell Biology, University of Münster, D-48149, Münster, Germany. los@uni-muenster.de
Stroh
C
C
Jänicke
R U
RU
Engels
I H
IH
Schulze-Osthoff
K
K
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D020169:Caspases / Q000502:physiology / Q000633:toxicity*; D006801:Humans; D013601:T-Lymphocytes / Q000166:cytology / Q000201:enzymology
D020169:Caspases