Azadirachtin, a neem biopesticide: subchronic toxicity assessment in rats.
Azadirachtin, a biopesticide obtained from neem, was subjected to subchronic toxicological testing to document its safety for use as a pesticide. Azadirachtin technical 12% orally administered to male and female rats at doses of 500, 1000 and 1500 mg/kg/day for 90 days did not produce any signs of toxicity, mortality, changes in tissue weight, pathology and serum and blood parameters. It can be suggested that azadirachtin at the highest dose tested is well tolerated by rats of both sexes. The highest dose, 1500 mg/kg, can be used as a basal dose for the determination of the no-observed-effect level (NOEL) of azadirachtin to calculate its safety margin.
Raizada
R B
RB
Pesticide Toxicology Laboratory, Industrial Toxicology Research Centre, Post Box No. 80, M.G.Marg, -226001, Lucknow, India. intox@itrc.sirnetd.emet.in
Srivastava
M K
MK
Kaushal
R A
RA
Singh
R P
RP
D000284:Administration, Oral; D000818:Animals; D000962:Antimalarials / Q000633:toxicity; D001835:Body Weight; D005260:Female; D005989:Glycerides / Q000737:chemistry; D007306:Insecticides / Q000633:toxicity*; D036701:Limonins; D008297:Male; D015394:Molecular Structure; D019055:No-Observed-Adverse-Effect Level; D009929:Organ Size; D051381:Rats; D013729:Terpenes / Q000737:chemistry; D014315:Triterpenes / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity*
D000962:Antimalarials; D005989:Glycerides; D007306:Insecticides; D036701:Limonins; D013729:Terpenes; D014315:Triterpenes; C002443:neem oil; C010329:azadirachtin