Clofazimine enteropathy in a pediatric bone marrow transplant recipient.
Clofazimine, previously used in the treatment of leprosy, is now used for treatment of Mycobacterium avium complex infection in patients with acquired immune deficiency syndrome, dermatologic disorders, and graft-versus-host disease. An 11-year-old boy developed a severe enteropathy 2 years after initiation of clofazimine treatment for graft-versus-host disease. Clofazimine enteropathy caused by crystal deposition can be life-threatening.
Parizhskaya
M
M
Department of Pathology, Division of Gastroenterology, Children's Hospital of Pittsburgh and the University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15513, USA.
Youssef
N N
NN
Di Lorenzo
C
C
Goyal
R K
RK
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D001706:Biopsy; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D002991:Clofazimine / Q000009:adverse effects*; D004378:Duodenal Diseases / Q000139:chemically induced* / Q000473:pathology; D004386:Duodenum / Q000473:pathology; D016099:Endoscopy, Gastrointestinal; D006086:Graft vs Host Disease / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D007077:Ileal Diseases / Q000139:chemically induced* / Q000473:pathology; D008297:Male
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002991:Clofazimine