title: Vitamin E and exertional rhabdomyolysis during endurance sled dog racing.
abstract: Exertional rhabdomyolysis (ER) is common in sled dogs, animals with high energy expenditures that consume high fat (60% of ingested calories) diets. Associations between pre-race plasma [vitamin E] and total antioxidant status (TAS) and risk of developing ER were examined in dogs competing in the 1998 Iditarod race. Pre-race blood samples were collected from 750 dogs and a second sample was collected from 158 dogs withdrawn from the race at various times. Plasma creatine kinase activity was used to identify withdrawn dogs with ER. There was no association between pre-race plasma [vitamin E] and risk of development of ER. Dogs that developed ER started the race with higher TAS, but when withdrawn, had lower TAS than unaffected dogs and had similar pre-race [vitamin E] but higher [vitamin E] at time of withdrawal. Hence, the risk of ER in sled dogs is not affected by plasma [vitamin E] before the race.
authors: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Ohio State University, Columbus, OH 43210-1089, USA.
authors: R J
authors: RJ
authors: Piercy
authors: K W
authors: KW
authors: Hinchcliff
authors: P S
authors: PS
authors: Morley
authors: R A
authors: RA
authors: DiSilvestro
authors: G A
authors: GA
authors: Reinhart
authors: S L
authors: SL
authors: Nelson
authors: K E
authors: KE
authors: Schmidt
authors: A M
authors: AM
authors: Craig
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D015984:Causality; D003402:Creatine Kinase / Q000097:blood; D004285:Dogs; D005609:Free Radicals / Q000378:metabolism; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010805:Physical Conditioning, Animal / Q000502:physiology*; D005082:Physical Exertion / Q000502:physiology*; D012206:Rhabdomyolysis / Q000209:etiology / Q000378:metabolism* / Q000503:physiopathology; D014810:Vitamin E / Q000097:blood*; D014811:Vitamin E Deficiency / Q000097:blood / Q000150:complications / Q000503:physiopathology
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D014810:Vitamin E; D003402:Creatine Kinase