title: An individual patient data meta-analysis of long supported adjuvant chemotherapy with oral carmofur in patients with curatively resected colorectal cancer.
abstract: To reappraise the benefits of the long supported chemotherapy with carmofur, a meta-analysis based on individual patient data from the three clinical trials was performed by pooling 614 patients from three trials, there is a statistically significant survival benefit (2p=0.032) and disease-free survival (DFS) benefit (2p=0.021) for carmofur; and a highly significant advantage for carmofur in DFS (2p=0.0004) and in survival (2p=0.004) in Dukes' C patients. This IPD meta-analysis strongly suggested an effect of oral carmofur in a long supported chemotherapy for curatively resected colorectal carcinoma.
authors: Department of Surgery and Laboratory of Clinical Oncology, Aichi, Prefectural Hospital, Kakemachi, Okazaki 444-0011, Aichi Prefecture, Japan. suchan@sun-inet.or.jp
authors: J
authors: J
authors: Sakamoto
authors: S
authors: S
authors: Kodaira
authors: C
authors: C
authors: Hamada
authors: K
authors: K
authors: Ito
authors: Y
authors: Y
authors: Maehara
authors: H
authors: H
authors: Takagi
authors: K
authors: K
authors: Sugimachi
authors: H
authors: H
authors: Nakazato
authors: Y
authors: Y
authors: Ohashi
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D018572:Disease-Free Survival; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D012004:Rectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; C017367:carmofur; D005472:Fluorouracil