title: A preliminary open label dose comparison using an antioxidant regimen to determine the effect on viral load and oxidative stress in men with HIV/AIDS.
abstract: OBJECTIVE
  To investigate the effect of antioxidant supplementation on viral load and the antioxidant/reactive oxygen species system in people with HIV.
  
  
  METHODS
  Single centre, prospective, dose comparison study.
  
  
  METHODS
  Outpatient clinic specializing in HIV care.
  
  
  METHODS
  Sixty-six participants were sequentially recruited by advertisement, and 48 subjects completed the study.
  
  
  METHODS
  A recommended dose antioxidant regimen (5,450 IU vitamin A as beta-carotene, 250 mg vitamin C, 100 IU vitamin E, 100 microg selenium, 50 mg coenzyme Q10) or a high-dose antioxidant regimen (21,800 IU vitamin A as beta-carotene, 1,000 mg vitamin C, 400 IU vitamin E, 200 microg selenium, 200 mg coenzyme Q10) for a 12 week period.
  
  
  RESULTS
  Using repeated measures analysis of variance, the changes over treatment time were significant for selenium, glutathione, glutathione peroxidase and lipid peroxides (P < 0.03). Changes in allantoin, uric acid and viral load were not significant (P > 0.05). The main effects for group and the interaction effects were not significant for any of the parameters measured (P > or = 0.05).
  
  
  CONCLUSIONS
  Antioxidant supplementation significantly improved some measures of oxidative defence. There was no benefit in using a high-dose supplement in this study.
authors: The Albion Street Centre, Randwick, Australia. marijka@uow.edu.au
authors: M
authors: M
authors: Batterham
authors: J
authors: J
authors: Gold
authors: D
authors: D
authors: Naidoo
authors: O
authors: O
authors: Lux
authors: S
authors: S
authors: Sadler
authors: S
authors: S
authors: Bridle
authors: M
authors: M
authors: Ewing
authors: C
authors: C
authors: Oliver
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000975:Antioxidants / Q000008:administration & dosage* / Q000627:therapeutic use; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress / Q000187:drug effects*; D011446:Prospective Studies; D017382:Reactive Oxygen Species; D019562:Viral Load
chemical_list: D000975:Antioxidants; D017382:Reactive Oxygen Species