Adverse effect of dentine bonding agent on the oral mucosa of guinea pigs.
The purpose of present study was to determine the possibility of nebulous discoloration of the oral mucosa of guinea pigs as a result of the application of dentine bonding agents. The materials used were the Clearfil Photo Bond (CPB) system's mixture agent, universal agent and catalyst agent. Four types of experimental catalysts were used. In male albino guinea pigs weighing 300-500 g, oral mucosa irritation tests were performed in accordance with the guidelines of the Cosmetic, Toiletry and Fragrance Association (CTFA). Macroscopical findings on the oral mucosa showed that there was strong nebulous discoloration immediately after application of CPB mix and CPB catalyst and throughout the experimental periods. However, CPB without 10-methacryloxdecyl dihydrogen phosphate (MDP) did not produce noticeable nebulous discoloration and inflammation. The CPB mix caused pathological changes, such as paraketosis and hyperkeratosis on the endepidermis of the mucosa, immediately after its application.
Manabe
A
A
Department of Operative Dentistry, School of Dentistry, University of Showa, Tokyo, Japan.
Katsuno
K
K
Kurihara
A
A
Itoh
K
K
Hisamitsu
H
H
Wakumoto
S
S
Iijima
M
M
Yoshida
T
T
D000818:Animals; D001585:Benzoyl Peroxide / Q000009:adverse effects; D017220:Dentin-Bonding Agents / Q000009:adverse effects*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005881:Gingiva / Q000187:drug effects / Q000473:pathology; D005891:Gingivitis / Q000139:chemically induced / Q000473:pathology; D006168:Guinea Pigs; D007972:Leukoplakia, Oral / Q000139:chemically induced / Q000473:pathology; D008297:Male; D008689:Methacrylates / Q000009:adverse effects; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology; D009504:Neutrophils / Q000473:pathology; D019279:Resin Cements / Q000009:adverse effects*; D013280:Stomatitis / Q000139:chemically induced; D013729:Terpenes / Q000009:adverse effects
D017220:Dentin-Bonding Agents; D008689:Methacrylates; D019279:Resin Cements; D013729:Terpenes; C074669:Clearfil Photo Bond; C048339:camphoroquinone; C005044:hydroxyethyl methacrylate; C069749:methacryloyloxydecyl dihydrogen phosphate; D001585:Benzoyl Peroxide