title: Auditory P3a deficits in male subjects at high risk for alcoholism.
abstract: BACKGROUND
  Substantial evidence indicates that alcoholism is biologically mediated by a genetic predisposition. As the decreased P300 (P3b) event-related brain potential component does not recover with prolonged abstinence, it is unlikely to be related to drinking history but is more likely to be genetically influenced. This is supported by findings that P3b amplitudes are reduced in subjects at high-risk compared to low-risk for alcoholism. Although there are few studies of P3a in HR subjects, lower P3a amplitudes have been reported with a novel nontarget stimulus paradigm, as well as with a difficult three-stimulus visual paradigm. Using a similar three-tone auditory paradigm in which the discriminability between the target and standard tone is difficult, the P3a component can also be reliably elicited with a rare nontarget perceptually distinct stimulus. This technique was employed in young adult subjects at low-risk and high-risk for alcoholism.
  
  
  METHODS
  A total of 17 low-risk and 24 high-risk male subjects were employed as subjects in an auditory paradigm that yielded a large amplitude P3a with a centro-frontal maximum to the nontarget and a robust low amplitude prolonged P3b with a parietal maximum amplitude to the target stimulus. Current source density maps were derived to assess topographic differences between low-risk and high-risk subjects.
  
  
  RESULTS
  The high-risk group manifested significantly lower P3a amplitudes than the low-risk group at the frontal electrodes to rare nontarget stimuli. High-risk subjects also demonstrated a more disorganized current source density map for P3a compared to low-risk subjects.
  
  
  CONCLUSIONS
  The reduction of P3a in the high-risk group may be due to cortical dysfunction including the frontal and prefrontal cortex. The lower P3a amplitude coupled with more disorganized current source density maps suggest inefficient brain functioning in high-risk subjects.
authors: Department of Psychiatry, SUNY Health Science Center at Brooklyn, Brooklyn, NY 11203, USA.
authors: M
authors: M
authors: Hada
authors: B
authors: B
authors: Porjesz
authors: D B
authors: DB
authors: Chorlian
authors: H
authors: H
authors: Begleiter
authors: J
authors: J
authors: Polich
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000437:Alcoholism / Q000503:physiopathology*; D001931:Brain Mapping; D018913:Event-Related Potentials, P300 / Q000502:physiology*; D005625:Frontal Lobe / Q000503:physiopathology*; D006801:Humans; D008297:Male; D012306:Risk; D013647:Task Performance and Analysis