title: Amino acids and peptides. XXXVIII. Facile synthesis of laminin-related peptide-poly(ethylene glycol) hybrids by the solid phase method.
abstract: Poly(ethylene glycol) (PEG) has been studied as a drug-carrier for proteins, but not for small peptides. Laminin, a cell adhesive protein, has Tyr-Ile-Gly-Ser-Arg (YIGSR) sequence and peptides containing this sequence inhibit experimental metastasis. We have studied PEG hybrids of YIGSR and other small laminin-related peptides. In a previous paper, we reported preparation of YIGSR-PEG hybrids by combination of the solid phase method and the solution method, but the synthetic procedure was problematic. Here we report a facile synthesis of PEG hybrids of YIGSR (PEG-YIGSR, YIGSR-PEG, PEG-YIGSR-PEG) by the solid phase method.
authors: Faculty of Pharmaceutical Sciences and High Technology Research Center, Kobe Gakuin University, Japan.
authors: M
authors: M
authors: Maeda
authors: H
authors: H
authors: Kamada
authors: K
authors: K
authors: Hojo
authors: Y
authors: Y
authors: Yamamoto
authors: S
authors: S
authors: Nakagawa
authors: T J
authors: TJ
authors: Smith
authors: T
authors: T
authors: Mayumi
authors: K
authors: K
authors: Kawasa
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004337:Drug Carriers / Q000737:chemistry; D007797:Laminin / Q000138:chemical synthesis* / Q000494:pharmacology; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000473:pathology / Q000517:prevention & control; D010455:Peptides / Q000138:chemical synthesis* / Q000494:pharmacology; D011092:Polyethylene Glycols / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004337:Drug Carriers; D007797:Laminin; D010455:Peptides; D011092:Polyethylene Glycols