Strategies for improved antigen delivery into dendritic cells.
Efficacious vaccines against cancers and infectious diseases will, in general, need to elicit comprehensive immune responses, including cytotoxic T lymphocyte activity. Because of their unique T cell stimulatory capacities, dendritic cells (DC) have emerged as the most potent antigen-presenting cell. Vaccination strategies should therefore aim at the acquisition and display of the antigen(s) of choice by DC. Results from vaccination studies, in animal models and in humans, stress the need for optimized antigen delivery systems to DC, to increase vaccination efficacy as well as to improve control on the immunological outcome. Here, we discuss the advantages and limitations of several recently described methodologies for antigen delivery into DC.
Rea
D
D
Tumorimmunology Group, Dept of Immunohematology & Bloodtransfusion, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands.
Johnson
M E
ME
Havenga
M J
MJ
Melief
C J
CJ
Offringa
R
R
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D002465:Cell Movement; D002470:Cell Survival; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007167:Immunotherapy; D066298:In Vitro Techniques; D051379:Mice; D009369:Neoplasms / Q000276:immunology / Q000628:therapy; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014611:Vaccination; D014612:Vaccines / Q000276:immunology*
D014612:Vaccines