Diverse biological activities of healthy foods.
Diverse biological activities of 7 healthy foods [powdered pine needle, citrate-fermented sesame, powdered coffee, royal jelly, propolis, pollen and white sesame oil (extracted by super critical state (40 degrees C, 350 atmospheric pressure))] were investigated. The pine needle, sesame and powdered coffee was also extracted successively by ethanol and hot water, and lyophilized. The pine needle and coffee extracts, and propolis showed higher in vitro cytotoxic, bactericidal and oxidation activity, as compared with other 4 lipophilic healthy foods. However, propolis showed slightly lower, but significant cytotoxic and bactericidal activity with much reduced oxidation potential. ESR spectroscopy demonstrated that the cytotoxic activity of these extracts was closely related to their radical generation and O2- scavenging activities. Healthy food components may have both pro-oxidant and anti-oxidant properties. Pre-treatment of mice with pine needle, sesame or powdered coffee extract significantly reduced the lethality of bacterial infection, possibly due to their host-mediated action. These extracts failed to reduce the cytophatic effect of HIV-1 (human immunodeficiency virus) infection in MT-4 cells. No apparent acute toxicity was detected in mice by oral administration of 10 g/kg of these extracts. This data suggest the medicinal efficacy of healthy foods.
Kobayashi
N
N
Fujimi Bee House, Shiki, Saitama, Japan.
Unten
S
S
Kakuta
H
H
Komatsu
N
N
Fujimaki
M
M
Satoh
K
K
Aratsu
C
C
Nakashima
H
H
Kikuchi
H
H
Ochiai
K
K
Sakagami
H
H
D000818:Animals; D019380:Anti-HIV Agents / Q000633:toxicity; D000975:Antioxidants / Q000633:toxicity; D015496:CD4-Positive T-Lymphocytes / Q000166:cytology / Q000821:virology; D002294:Carcinoma, Squamous Cell; D003069:Coffee; D004578:Electron Spin Resonance Spectroscopy; D005227:Fatty Acids / Q000633:toxicity*; D005260:Female; D058870:Food, Organic; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010936:Plant Extracts / Q000633:toxicity; D018515:Plant Leaves; D011058:Pollen; D011429:Propolis / Q000633:toxicity*; D012715:Sesame Oil / Q000633:toxicity*; D013203:Staphylococcal Infections / Q000188:drug therapy; D014407:Tumor Cells, Cultured; D000099219:Royal Jelly
D019380:Anti-HIV Agents; D000975:Antioxidants; D003069:Coffee; D005227:Fatty Acids; D010936:Plant Extracts; D011429:Propolis; D012715:Sesame Oil; D000099219:Royal Jelly