title: Differentiation of radiographically indeterminate solitary pulmonary nodules with.
abstract: BACKGROUND
  The purpose of this preliminary study was to evaluate the efficacy of positron emission tomography (PET) with [18F]fluoro-2-deoxyglucose (FDG) for differentiating benign from malignant solitary pulmonary nodules.
  
  
  METHODS
  Twenty-six patients (12 females, 14 males, age 27-79 years) with radiographically indeterminate solitary pulmonary nodules underwent FDG-PET and the findings were compared with the results of pathological examination of biopsy samples. FDG activity in the lesion was expressed as the ratio of lesion-to-background counts (L/B ratio) for semiquantitative analysis.
  
  
  RESULTS
  The mean L/B ratio of malignant lesions (8.81+/-3.71, n = 20) was not significantly higher than that of benign lesions (4.71+/-3.00, n = 6) (p = 1.00). Using a cut-off L/B ratio of 5.0 for malignancy, FDG-PET correctly detected 19 true positive and three true negative cases, but failed to detect three false positive (two abscesses and one cryptococcus) cases and one false negative (adenocarcinoma) case. The sensitivity, specificity, accuracy, positive predictive value and negative predictive value were 95, 50, 86, 75 and 85%, respectively.
  
  
  CONCLUSIONS
  FDG-PET is a sensitive modality for detecting malignancy, but is not specific enough. Benign lung lesion with active inflammation could demonstrate high FDG uptake, making it difficult to differentiate from malignancy. In the future, we will increase the case numbers to evaluate further the utility of FDG-PET for differentiating radiographically indeterminate solitary pulmonary nodules.
authors: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taiwan.
authors: G U
authors: GU
authors: Hung
authors: Y C
authors: YC
authors: Shiau
authors: S C
authors: SC
authors: Tsai
authors: Y J
authors: YJ
authors: Ho
authors: C H
authors: CH
authors: Kao
authors: R F
authors: RF
authors: Yen
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D012680:Sensitivity and Specificity; D003074:Solitary Pulmonary Nodule / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18