Osteoporosis after renal transplantation: single center experience.
BACKGROUND
Osteoporosis is a major source of morbidity after renal transplantation. The aim of this retrospective study was to determine the independent influences of different parameters on bone mineral density (BMD) in various parts of the body after renal transplantation.


METHODS
BMD was measured in 130 of 954 renal allograft recipients who underwent surgery between 1985 and 1999.


RESULTS
Time since transplantation and cumulative prednisolone doses were significantly higher in patients who had osteoporosis of the lumbar vertebrae (P=0.06 and 0.034, respectively). Logistic regression analysis revealed that cumulative prednisolone dose was the only significant predictor of low vertebral BMD (P=0.02, r=0.33). For the neck of the femur, high blood urea nitrogen and low Mg levels were found to be the predictors of low bone density (P=0.002 and 0.04, respectively). Although parathyroid hormone levels were higher in femoral osteoporosis patients than in those not affected at this site, the difference was not statistically significant (P=0.294). Time since transplantation, cumulative prednisolone dose, and cyclosporine A dose were all found to have a major negative impact on BMD in the radius region (P=0.001, 0.000, 0.001, respectively). Regression analysis showed that cumulative prednisolone dose (P=0.0008, r=0.34), time since transplantation (P=0.005, r=0.27), body mass index (P=0.01, r=-0.21), male gender (P=0.02, r=-0.21), and age (P=0.04, r=0.16) all had major effects on radius BMD. In conclusion, the radius seems to be one of the major parts of the skeleton affected by factors introduced after renal transplantation.
Ugur
A
A
Department of Endocrinology, Baskent University Faculty of Medicine, Ankara, Turkey.
Guvener
N
N
Işiklar
I
I
Turan
M
M
Erdal
R
R
Haberal
M
M
D000328:Adult; D015519:Bone Density; D016572:Cyclosporine / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005272:Femur Neck / Q000378:metabolism; D005938:Glucocorticoids / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation / Q000009:adverse effects*; D008159:Lumbar Vertebrae / Q000378:metabolism; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced / Q000209:etiology* / Q000378:metabolism; D011239:Prednisolone / Q000009:adverse effects; D011884:Radius / Q000378:metabolism; D012189:Retrospective Studies; D013997:Time Factors
D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D016572:Cyclosporine; D011239:Prednisolone