[Evaluation of pharmacodynamic properties of medium-mineralized alkaline water designed for distribution as bottled natural mineral water].
Basing on the carried-out investigations it has been shown that the alkaline water from "Paproć" source in Tymbark indicates a biological activity. Applied in rats orally, in an appropriate dose through the period of 30 days, it causes a statistically significant increase of the pH of urine and blood, of the level of uric acid in urine and a statistic lowering of the levels of calcium and potassium in the blood serum. The investigated water shows diuretic activity, neutralizes and inhibits gastric juice secretion in people, affects the peristaltic movements of the smooth muscles of the small intestine of the rabbit. No effect of that water on the elements of the protein metabolism, the fat metabolism, on the smear and the morphological composition of the peripheral blood of rats, on the excretion of bile in guinea pigs has been observed.
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Zakład Tworzyw Uzdrowiskowych Państwowy Zakład Higieny 60-821 Poznań, ul. Słowackiego 8/10.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000468:Alkalies / Q000032:analysis / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D005744:Gastric Acid / Q000378:metabolism; D006168:Guinea Pigs; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000097:blood; D008903:Minerals / Q000494:pharmacology*; D010528:Peristalsis / Q000187:drug effects; D011044:Poland; D011188:Potassium / Q000097:blood; D051381:Rats; D017208:Rats, Wistar; D012964:Sodium / Q000097:blood; D014527:Uric Acid / Q000652:urine; D014556:Urine / Q000737:chemistry; D014881:Water Supply / Q000032:analysis*
D000468:Alkalies; D004573:Electrolytes; D008903:Minerals; D014527:Uric Acid; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium