The effect of zinc supplementation on antioxidant and lipid peroxidation status during Brachiaria decumbens intoxication in sheep.
An attempt was made to clarify the association between zinc (Zn) and antioxidants due to Zn supplementation on lipid peroxidation occurring during Brachiaria decumbens intoxication. The concentration of Zn, copper, malondialdehyde (MDA), superoxide dismutase (SOD), and gluthathione peroxidase (GSH-Px) were determined in tissues. There was a gradual increment in the concentration of Zn and MDA in serum and hepatocytic SOD in groups given Zn + B decumbens. A decline in erythrocytic GSH-Px and SOD, and lower concentration of reduced glutathione in hepatocyte cytosols were also detected in these sheep. It is highly suggestive that Zn supplementation may depress antioxidant status and enhance lipid peroxidation during B decumbens intoxication.
Zhang
S S
SS
Faculty of Veterinary Medicine, Universiti Putra Malaysia, Serdang, Selangor.
Noordin
M M
MM
Rahman
S O
SO
Haron
M J
MJ
D000821:Animal Feed; D000818:Animals; D019587:Dietary Supplements / Q000009:adverse effects*; D004912:Erythrocytes / Q000187:drug effects; D005978:Glutathione / Q000097:blood / Q000187:drug effects; D005979:Glutathione Peroxidase / Q000097:blood / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008315:Malondialdehyde / Q000032:analysis; D008897:Panicum / Q000506:poisoning; D010939:Plant Poisoning / Q000209:etiology / Q000378:metabolism / Q000662:veterinary*; D006109:Poaceae / Q000506:poisoning*; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000097:blood / Q000187:drug effects; D015032:Zinc / Q000009:adverse effects* / Q000032:analysis
D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione; D015032:Zinc