Blunted adenosine A2a receptor function in platelets in patients with major depression.
There is provisional evidence of involvement of adenosine in depression. In this study, the second messenger intracellular calcium response in platelets was measured in patients with major depression and controls using spectrofluorometry. The primary result of this study was a statistically significantly blunted second messenger response to agonist stimulation in the depressed group compared to the control group at the 50 and 100 nM and 1 microM dosage levels. This suggests that dysregulation of the adenosine A2a receptor may be present in depression.
Berk
M
M
Department of Psychiatry, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa. 039berk@chiron.wits.ac.za
Plein
H
H
Ferreira
D
D
Jersky
B
B
D000241:Adenosine / Q000031:analogs & derivatives*; D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000097:blood; D003866:Depressive Disorder / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005456:Fluorescent Dyes; D016257:Fura-2; D006801:Humans; D008297:Male; D008875:Middle Aged; D010627:Phenethylamines; D011569:Psychiatric Status Rating Scales; D058915:Purinergic P1 Receptor Antagonists; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1 / Q000097:blood*; D013050:Spectrometry, Fluorescence
D005456:Fluorescent Dyes; D010627:Phenethylamines; D058915:Purinergic P1 Receptor Antagonists; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; D000241:Adenosine; D002118:Calcium; D016257:Fura-2