title: The effect of time of day and repeat reliability on the fast flicker multifocal ERG.
abstract: OBJECTIVE
  To investigate the possible influence of different times of the day on multifocal ERG recordings in normals.
  
  
  METHODS
  10 healthy volunteers underwent multifocal ERG recordings (VERIS 3.1.1.) 3 times a day, at 10:30 am, 1:30 pm and 4:30 pm using a fast flicker stimulus of 103 hexagons. Additional night-time recordings were performed in 2 subjects. The first-order and dominant part of the second order response component were analyzed.
  
  
  RESULTS
  Neither peak latencies nor peak-to-peak amplitudes showed significant changes during the day (p >0.05). Comparison between night and day time recordings did also not reveal an influence of a circadian rhythm on the MF-ERG.
  
  
  CONCLUSIONS
  No significant influence of the time of the day suggestive of a circadian rhythm could be observed. Light adaptation due to preadaptation and the flicker sequence used could be a possible cause for these results.
authors: Department of Ophthalmology and Eye Hospital, University of the Saarland, Homburg, Germany. aubhei@med-rz.uni-sb.de
authors: B
authors: B
authors: Heinemann-Vernaleken
authors: A
authors: A
authors: Palmowski
authors: R
authors: R
authors: Allgayer
mesh_terms: D000221:Adaptation, Ocular / Q000502:physiology*; D000328:Adult; D002940:Circadian Rhythm / Q000502:physiology*; D004596:Electroretinography; D005260:Female; D006801:Humans; D008297:Male; D015203:Reproducibility of Results; D012160:Retina / Q000502:physiology*; D013997:Time Factors