title: Left ventricular systolic dysfunction in 75-year-old men and women; a population-based study.
abstract: OBJECTIVE
  To determine the prevalence of left ventricular systolic dysfunction in 75-year-old men and women.
  
  
  RESULTS
  In a population-based random sample of 75-year-old subjects (n=433; response rate 70.1%) the left ventricular systolic function was determined using two echocardiographic methods: (1) wall motion in nine left ventricular segments was visually scored and wall motion index was calculated as the mean value of the nine segments and (2) ejection fraction as measured by the disc summation method. Presence of heart failure was determined by a cardiologist's clinical evaluation. Wall motion index was achievable in 95% of the participants while ejection fraction was measurable in 65%. Normal values were obtained from a healthy subgroup (n=108) and left ventricular systolic dysfunction was defined as the 0.5th percentile of the wall motion index (i.e. <1.7). In participants in whom both ejection fraction and wall motion index were achievable, wall motion index <1.7 predicted ejection fraction <43% with a sensitivity and specificity of 84.0% and 99.6%, respectively. The prevalence of left ventricular systolic dysfunction was 6.8% (95% CI, 5.6--8.0%) and was greater in men than in women (10.2% vs 3.4%, P=0.006). Clinical evidence of heart failure was absent in 46% of the participants with left ventricular systolic dysfunction.
  
  
  CONCLUSIONS
  Left ventricular systolic dysfunction is common among 75-year-olds with a prevalence of 6.8% in our estimate. The condition is more likely to affect men than women. In nearly half of 75-year-olds with left ventricular systolic dysfunction there is no clinical evidence of heart failure.
authors: Department of Clinical Physiology, Central Hospital, Västerås, Sweden.
authors: P
authors: P
authors: Hedberg
authors: I
authors: I
authors: Lönnberg
authors: T
authors: T
authors: Jonason
authors: G
authors: G
authors: Nilsson
authors: K
authors: K
authors: Pehrsson
authors: I
authors: I
authors: Ringqvist
mesh_terms: D017677:Age Distribution; D000368:Aged; D003327:Coronary Disease / Q000150:complications; D048909:Diabetes Complications; D004452:Echocardiography / Q000379:methods / Q000592:standards; D005080:Exercise Test; D005260:Female; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D006973:Hypertension / Q000150:complications; D008297:Male; D011159:Population Surveillance; D015995:Prevalence; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D017678:Sex Distribution; D013318:Stroke Volume; D011795:Surveys and Questionnaires; D013548:Sweden / Q000453:epidemiology; D013599:Systole; D014504:Urban Health / Q000706:statistics & numerical data; D018487:Ventricular Dysfunction, Left / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology / Q000503:physiopathology