title: Variability in doses obtained from a multi-dose ophthalmic solution: a potential source of error in the assessment of compliance.
abstract: BACKGROUND
  Assessment of compliance with prescribed therapy is an important aspect of patient management that can be overlooked. Compliance with topical ophthalmic medications is frequently assessed without knowledge of doses obtained per bottle.
  
  
  METHODS
  Thirty-three normal subjects who agreed to participate were asked to instill one drop of Refresh Tears in each eye twice daily until a 3-ml bottle was empty. Each subject was also asked to record the date and time of each drop instillation using a calendar log sheet. On enrollment, the subjects were required to demonstrate proper drop instillation technique. With the use of the log sheets, doses obtained and administrations missed by each subject were tabulated. The 'expected count' per bottle was determined by counting the drops in Refresh Tears under laboratory conditions.
  
  
  RESULTS
  Of the 26 subjects, who completed the study, the mean (SD) number of doses reportedly obtained was 63.7 +/- 17.1 (range = 26 to 110). The mean number of drops counted per bottle was 63.5 +/- 1.0 (range = 62 to 65).
  
  
  CONCLUSIONS
  The range of doses reportedly obtained per bottle was quite large. This variability could represent a significant source of error if patient compliance is assessed by how long a bottle lasts.
authors: Illinois College of Optometry, Chicago 60616, USA. jwinters@eyecare.ico.edu
authors: J E
authors: JE
authors: Winters
authors: D D
authors: DD
authors: Castells
authors: G A
authors: GA
authors: Lesher
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D011307:Drug Prescriptions / Q000592:standards*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions / Q000008:administration & dosage*; D010349:Patient Compliance; D010353:Patient Education as Topic; D012016:Reference Values; D015203:Reproducibility of Results
chemical_list: D009883:Ophthalmic Solutions