Parkinson's disease with late Pick's dementia.
We report a case in which typical clinical features of idiopathic Parkinson's disease existed for seven years prior to the development of significant behavioral and cognitive changes and severe dementia. The patient presented with right-sided resting tremor, bradykinesia, and rigidity, which were highly responsive to levodopa. Serial neuropsychological evaluation revealed no evidence of dementia until late in the disease. The patient deteriorated rapidly eight years into the disease, requiring full care. She died 16 years after symptom onset and post-mortem neuropathological analysis revealed Lewy body Parkinson's disease and Pick's disease. To our knowledge, this is the first non-familial case with this combination of clinical history and pathologically confirmed disease to be reported in the literature. The absence of a family history of any neurological disease sets this case apart from the recently described genetic cases of frontotemporal dementia with Parkinsonism linked to chromosome 17. In addition, the relatively late onset of dementia in frontotemporal dementia is atypical. While there is considerable debate regarding the cause of dementia in idiopathic Parkinson's disease, our case illustrates that Pick's disease is one such cause.
Henderson
J M
JM
Prince of Wales Medical Research Institute, Sydney, Australia. j.henderson@unsw.edu.au
Gai
W P
WP
Hely
M A
MA
Reid
W G
WG
Walker
G L
GL
Halliday
G M
GM
D000203:Activities of Daily Living; D000367:Age Factors; D001037:Aphasia / Q000175:diagnosis / Q000209:etiology; D001284:Atrophy / Q000473:pathology; D001921:Brain / Q000378:metabolism / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis; D004185:Disability Evaluation; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000378:metabolism / Q000473:pathology; D001523:Mental Disorders / Q000175:diagnosis / Q000209:etiology; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009483:Neuropsychological Tests; D010300:Parkinson Disease / Q000150:complications* / Q000175:diagnosis; D020774:Pick Disease of the Brain / Q000150:complications* / Q000175:diagnosis; D011930:Reaction Time; D012720:Severity of Illness Index; D051843:Synucleins; D016875:tau Proteins / Q000378:metabolism
D009419:Nerve Tissue Proteins; D051843:Synucleins; D016875:tau Proteins