title: A multicenter, matched case-control study of risk factors for equine laminitis.
abstract: Risk factors for equine laminitis were examined in a prospective case-control study of the 258 cases seen at six collaborating veterinary teaching hospitals over a 32-month period. Case-control pairs were matched on institution, clinician, and season of diagnosis. The 90% of case-control pairs (78 acute, 155 chronic) that had complete data for age, gender, and breed were used in separate conditional logistic-regression models for acute and chronic laminitis. There was an increase in risk for horses with acute laminitis from 5 to 7 years of age (OR 4.7, 95% CI 1.3-16) and from 13 to 31 years of age (OR 3.9, 95% CI 1.3-12) (both compared to <5 years); risk was increased for chronic laminitis from 10 to 14 years (OR 3, 95% CI 1.4-6.8) and from 15 to 38 years (OR 2.9, 95% CI 1.4-6.1) (both compared to <6 years). Mares - but not stallions - were more likely than geldings to develop acute laminitis (OR 2.6, 95% CI 1.1-6.2) and chronic laminitis (OR 2.0, 95% CI 1.1-3.6). In the small acute-laminitis data set, the breed variable was collapsed into three categories: Thoroughbred (THB, reference), the Quarter Horse (QH), and other (non-QH-THB). The non-QH-THB group was at increased risk of acute laminitis (OR 3.8, 95% CI 1.2-11.8). For the seven breed-group categories used in the chronic-laminitis model, however, all non-THB breed groups appeared significantly at risk as compared to the THB, with odds ratios ranging from 3.3 (95% CI 1.3-8.30) for the QH to 9.1 (95% CI 2.1-39.3) for ponies.
authors: Department of Veterinary Anatomy and Public Health, College of Veterinary Medicine, Texas A&M University, Mail Stop 4458, College Station, TX 77843-4458, USA.
authors: P
authors: P
authors: Alford
authors: S
authors: S
authors: Geller
authors: B
authors: B
authors: Richrdson
authors: M
authors: M
authors: Slater
authors: C
authors: C
authors: Honnas
authors: J
authors: J
authors: Foreman
authors: J
authors: J
authors: Robinson
authors: M
authors: M
authors: Messer
authors: M
authors: M
authors: Roberts
authors: D
authors: D
authors: Goble
authors: D
authors: D
authors: Hood
authors: M
authors: M
authors: Chaffin
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D000818:Animals; D001947:Breeding; D016022:Case-Control Studies; D002908:Chronic Disease; D005260:Female; D005534:Foot Diseases / Q000453:epidemiology / Q000662:veterinary*; D006724:Hoof and Claw; D006734:Horse Diseases / Q000453:epidemiology*; D006736:Horses; D015994:Incidence; D007249:Inflammation / Q000453:epidemiology / Q000662:veterinary; D007794:Lameness, Animal / Q000453:epidemiology*; D016015:Logistic Models; D008297:Male; D016017:Odds Ratio; D011446:Prospective Studies; D012307:Risk Factors; D012737:Sex Factors