title: Synthesis of indomethacin analogues for evaluation as modulators of MRP activity.
abstract: Synthesis of a range of indomethacin analogues, required for investigation in combination toxicity assays, bearing both N-benzyl and N-benzoyl groups, is described.
authors: Department of Chemistry, University College Cork, Ireland. a.r.maguire@ucc.ie
authors: A R
authors: AR
authors: Maguire
authors: S J
authors: SJ
authors: Plunkett
authors: S
authors: S
authors: Papot
authors: M
authors: M
authors: Clynes
authors: R
authors: R
authors: O'Connor
authors: S
authors: S
authors: Touhey
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000187:drug effects*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000737:chemistry; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry; D016861:Cyclooxygenase Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D007213:Indomethacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009363:Neoplasm Proteins / Q000187:drug effects
chemical_list: D018528:ATP-Binding Cassette Transporters; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000970:Antineoplastic Agents; D016861:Cyclooxygenase Inhibitors; D007213:Indomethacin; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D009363:Neoplasm Proteins