[A case of Miller Fisher syndrome with pharyngeal palsy as an initial symptom].
We report herein a rare case of Miller Fisher syndrome with pharyngeal palsy as an initial symptom. A 68-year-old man admitted to our hospital with pharyngeal palsy two weeks after a respiratory infection. He subsequently developed ataxic gait, paresthesia in the upper limbs and ophthalmoplegia. Double-filtrated-plasmapheresis had been performed four times and all the symptoms subsided within two months. In the acute phase of the disease, the titers of anti-GQ1b and GT1a antibodies were elevated. The titer of anti-GT1a antibody was higher than that of anti-GQ1b antibody. Recently, the activity of serum anti-GT1a antibody has been supposed to be associated with pharyngeal palsy. In the present case, higher titer of anti-GT1a antibody compared with that of anti-GQ1b antibody could possibly cause pharyngeal palsy as an initial symptom of Miller Fisher syndrome.
Taguchi
Y
Y
Second Department of Internal Medicine, Toyama Medical & Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan.
Takashima
S
S
Inoue
H
H
Kusunoki
S
S
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D004268:DNA-Binding Proteins / Q000276:immunology; D005732:Gangliosides / Q000276:immunology; D006801:Humans; D008297:Male; D019846:Miller Fisher Syndrome / Q000150:complications* / Q000276:immunology; D010243:Paralysis / Q000209:etiology*; D010608:Pharyngeal Diseases / Q000209:etiology*; D010940:Plant Proteins / Q000276:immunology
D001323:Autoantibodies; D004268:DNA-Binding Proteins; D005732:Gangliosides; D010940:Plant Proteins; C077485:GT-1a protein, Nicotiana tabacum