Porous calcium polyphosphate scaffolds for bone substitute applications -- in vitro characterization.
Porous structures were formed by gravity sintering calcium polyphosphate (CPP) particles of either 106-150 or 150-250 microm size to form samples with 30-45 vol% porosity with pore sizes in the range of 100 microm (40-140 microm). Tensile strength of the samples assessed by diametral compression testing indicated relatively high values for porous ceramics with a maximum strength of 24.1 MPa for samples made using the finer particles (106-150 microm). X-ray diffraction studies of the sintered samples indicated the formation of beta-CPP from the starting amorphous powders. In vitro aging in 0.1 M tris-buffered solution (pH 7.4) or 0.05 M potassium hydrogen phthalate buffered solution (pH 4.0) at 37 degreesC for periods up to 30d indicated an initial rapid loss of strength and P elution by 1 d followed by a more gradual continuing strength and P loss resulting in strengths at 30d equal to about one-third the initial value. The observed structures, strengths and in vitro degradation characteristics of the porous CPP samples suggested their potential usefulness as bone substitute materials pending subsequent in vivo behaviour assessment.
Pilliar
R M
RM
Institute of Biomaterials & Biomedical Engineering, University of Toronto, ON. bob.pilliar@utoronto.ca
Filiaggi
M J
MJ
Wells
J D
JD
Grynpas
M D
MD
Kandel
R A
RA
D018786:Bone Substitutes / Q000737:chemistry; D002130:Calcium Phosphates / Q000737:chemistry; D066298:In Vitro Techniques; D008855:Microscopy, Electron, Scanning; D009501:Neutron Activation Analysis; D010316:Particle Size; D011208:Powders; D013718:Tensile Strength; D014961:X-Ray Diffraction
D018786:Bone Substitutes; D002130:Calcium Phosphates; D011208:Powders; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; C485838:calcium phosphate, monobasic, anhydrous; C020243:calcium phosphate; C485829:calcium phosphate, dibasic, anhydrous