Three down and counting: the transformation of human mammary cells from normal to malignant in three steps.
An array of genetic mutations associated with human breast cancers has been identified. However, which specific combination of mutations permit normal cells to form breast cancer remains unknown. Elenbaas et al. recently described an experimental system for studying the genetic requirements for the development of breast cancer.
Barcellos-Hoff
M H
MH
Cancer and Tissue Biology, Life Sciences Division, Building 74-174, 1 Cyclotron Road, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA. MHBarcellos-Hoff@lbl.gov
D001940:Breast / Q000166:cytology; D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism*; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D018450:Disease Progression; D004847:Epithelial Cells / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D009154:Mutation