title: Cytotoxic T cells and mycobacteria.
abstract: How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to enhance this.
authors: Department of Biochemistry and Immunology, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil. clsilva@fmrp.usp.br
authors: C L
authors: CL
authors: Silva
authors: V L
authors: VL
authors: Bonato
authors: K M
authors: KM
authors: Lima
authors: A A
authors: AA
authors: Coelho-Castelo
authors: L H
authors: LH
authors: Faccioli
authors: A
authors: A
authors: Sartori
authors: A O
authors: AO
authors: De Souza
authors: S C
authors: SC
authors: Leão
mesh_terms: D000818:Animals; D001426:Bacterial Proteins; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D018834:Chaperonin 60; D018833:Chaperonins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008262:Macrophage Activation / Q000276:immunology; D051379:Mice; D009169:Mycobacterium tuberculosis / Q000235:genetics / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014376:Tuberculosis / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control*; D019444:Vaccines, DNA / Q000008:administration & dosage / Q000276:immunology*
chemical_list: D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D018834:Chaperonin 60; D019444:Vaccines, DNA; C074119:heat-shock protein 65, Mycobacterium; D018833:Chaperonins