title: Predisposing factors and outcome of Staphylococcus aureus bacteremia in neutropenic patients with cancer.
abstract: Staphylococcus aureus caused 30 of 438 (7%) cases of bacteremia in neutropenic patients with cancer during a 10-year study period. Acute leukemia as an underlying disease and severe oral mucositis were more frequent among patients with Staphylococcus aureus bacteremia (57% vs. 33%, P = 0.01, and 32% vs. 12%, P = 0.006, respectively) than among the 151 patients who had gram-negative bacteremia during the same study period. The most frequent source of Staphylococcus aureus bacteremia was the venous catheter (35% vs. 1%; P = 0.00001). Septic metastases were more frequent in patients with Staphylococcus aureus bacteremia (14% vs. 4%, P = 0.03). Attributable mortality was 10% and overall mortality 23%. Staphylococcus aureus bacteremia remains a significant cause of morbidity and mortality in neutropenic patients with cancer.
authors: Department of Hematology, Institut Catalá d'Oncología, Hospital Duran i Reynals, Ciutat Sanitaria i Universitària de Bellvitge, L'Hospitalet de Llobregat, Barcelona, Spain. egonzalez@csub.scs.es
authors: E
authors: E
authors: González-Barca
authors: J
authors: J
authors: Carratalà
authors: A
authors: A
authors: Mykietiuk
authors: A
authors: A
authors: Fernández-Sevilla
authors: F
authors: F
authors: Gudiol
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019072:Antibiotic Prophylaxis; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000097:blood / Q000150:complications / Q000382:microbiology; D019337:Hematologic Neoplasms / Q000150:complications* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000150:complications* / Q000382:microbiology; D011446:Prospective Studies; D012307:Risk Factors; D013203:Staphylococcal Infections / Q000097:blood / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus; D016896:Treatment Outcome