Nonparametric identification of the minimum effective dose.
We consider identifying the minimum effective dose (MED) in a dose-response study, where the MED is defined to be the lowest dose level producing an effect over that of the zero-dose control. Proposed herein is a nonparametric procedure based on the Mann-Whitney statistic incorporated with the step-down closed testing scheme. A numerical example demonstrates the feasibility of the proposed nonparametric procedure. Finally, the comparative results of a Monte Carlo level and power study for small sample sizes are presented and discussed.
Chen
Y I
YI
Institute of Statistics, National Central University, Chung-Li, Taiwan. ychen@stat.ncu.edu.tw
D000818:Animals; D001391:Azo Compounds / Q000008:administration & dosage; D001699:Biometry; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015233:Models, Statistical; D009010:Monte Carlo Method; D009282:Naphthalenesulfonates / Q000008:administration & dosage; D019055:No-Observed-Adverse-Effect Level; D012475:Salmonella / Q000187:drug effects / Q000235:genetics; D014116:Toxicology / Q000706:statistics & numerical data
D001391:Azo Compounds; D009282:Naphthalenesulfonates; C087595:C.I. Acid Red 114