Effect of halothane on the cerebral circulation in young children: a hysteresis phenomenon.
To determine the effect of halothane on the cerebral blood flow velocity (CBFV) with increasing then decreasing concentrations, 11 children scheduled for minor surgery were studied. Anaesthesia consisted of halothane, vecuronium, nitrous oxide in oxygen and a caudal block. End-tidal carbon dioxide, temperature, heart rate and systolic arterial pressure were maintained constant. CBFV increased significantly between 0.5 and 1.0 MAC (p <0.001), and 0.5 and 1.5 MAC of halothane (p <0.001), but was not different after increasing concentration from 1.0 to 1.5 MAC. During the decreasing phase, CBFV decreased significantly from 1.5 to 1.0 MAC of halothane (p <0.001), whereas there was no difference in CBFV when decreasing halothane MAC from 1.0 to 0.5 MAC. In children, the decrease in CBFV during decreasing halothane concentration is not superimposable to the increase in CBFV seen when increasing halothane concentration, suggesting the presence of cerebrovascular hysteresis to halothane.
Paut
O
O
Department of Anaesthesia, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada M5G 1X8. opaut@ap-tim.fr
Bissonnette
B
B
D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001783:Blood Flow Velocity / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D016343:Monitoring, Intraoperative / Q000379:methods; D017585:Ultrasonography, Doppler, Transcranial
D018685:Anesthetics, Inhalation; D006221:Halothane