[Silent ischemic cardiopathy: which diabetics to examine?].
Non-Invasive coronary investigations are positive in 12 to 52% (average 22%) of type II diabetics, and 11 to 30% (average 17%) of type i diabetics. These statistics vary according to bias of recruitment. Haemodynamic lesions are found at coronary angiography in 35 to 80% of patients who have at least one positive non-invasive investigation. Nine to 12% of diabetics have silent myocardial ischaemia (SMI) confirmed by coronary angiography, compared with 1.3 to 5.3% of non-diabetic controls paired for age and sex. The higher frequency of SMI in diabetics seems to be mostly due to the increased frequency of ischaemic heart disease in diabetics. The importance of cardiac autonomic neuropathy (CAN) in SMI is controversial. The risk factors associated with SMI are those usually associated with coronary artery disease: age, masculine gender, hypercholesterolaemia, hypertriglyceridaemia, hypertension, smoking, a family history of cardiovascular disease, insulin therapy (for type II diabetes), proteinuria, retinopathy, peripheral occlusive arterial disease.... The French recommendations for investigating SMI seem to be contradictory. A single risk score in a given patient could help codify the investigation of SMI in diabetics, but this type of score has not yet been validated.
Charpentier
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Service d'endocrino-diabétologie, centre hospitalier sud-francilien, Corbeil.
Riveline
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JP
Lardoux
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Mathieu
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Requeda
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Varroud-Vial
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D000328:Adult; D000368:Aged; D015897:Comorbidity; D017023:Coronary Angiography; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000453:epidemiology; D003929:Diabetic Neuropathies / Q000150:complications / Q000453:epidemiology; D003930:Diabetic Retinopathy / Q000453:epidemiology; D005080:Exercise Test; D005260:Female; D005602:France / Q000453:epidemiology; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D006937:Hypercholesterolemia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D009765:Obesity / Q000453:epidemiology; D018579:Patient Selection; D017410:Practice Guidelines as Topic; D011237:Predictive Value of Tests; D015995:Prevalence; D011379:Prognosis; D012307:Risk Factors; D014944:World Health Organization