Lymphoepithelioma-like carcinoma of the breast with associated sclerosing lymphocytic lobulitis.
The purpose of this article is to highlight an unusual form of breast carcinoma and discuss its differential diagnosis. A 50-year-old woman underwent wide local excision of a breast lump. Microscopic examination revealed features of a lymphoepithelioma-like carcinoma. Individual tumor cells were present within an abundant lymphoid stroma. Immunohistochemistry revealed the epithelial nature of the cells and excluded a diagnosis of lymphoma. In addition, surrounding nontumorous breast tissue displayed the histologic features of sclerosing lymphocytic lobulitis or lymphocytic mastopathy. This is the second report of a lymphoepithelioma-like carcinoma of the breast, but to the best of our knowledge, it is the first description of coexistent sclerosing lymphocytic lobulitis.
Naidoo
P
P
Division of Anatomical Pathology, School of Pathology and Laboratory Medicine, University of Natal, Durban, South Africa.
Chetty
R
R
D014408:Biomarkers, Tumor / Q000032:analysis; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000737:chemistry / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis; D008223:Lymphoma / Q000175:diagnosis; D008413:Mastitis / Q000473:pathology; D008875:Middle Aged; D012598:Sclerosis / Q000473:pathology
D014408:Biomarkers, Tumor; D007633:Keratins