title: Metastatic placental site trophoblastic tumor. Report of a case with complete response to chemotherapy.
abstract: BACKGROUND
  Placental site trophoblastic tumor (PSTT) is a rare form of gestational trophoblastic neoplasia, commonly insensitive to chemotherapeutic agents.
  
  
  METHODS
  We report on long-term remission in a patient with metastatic PSTT after etoposide, methotrexate, actinomycin D, cyclophosphamide and vincristine combination chemotherapy. The 27-year-old patient with metastatic lung PSTT was alive, without evidence of disease, > 40 months after treatment.
  
  
  CONCLUSIONS
  Treatment with multiagent chemotherapy can produce long-term remission, even in patients with metastatic PSTT.
authors: Department of Obstetrics and Gynecology, Ospedale San Raffaele, Via Olgettina 60, 20100 Milan, Italy.
authors: G
authors: G
authors: Mangili
authors: E
authors: E
authors: Garavaglia
authors: P
authors: P
authors: De Marzi
authors: F
authors: F
authors: Zanetto
authors: G
authors: G
authors: Taccagni
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D005047:Etoposide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000556:secondary; D008727:Methotrexate / Q000627:therapeutic use; D011247:Pregnancy; D012074:Remission Induction; D018245:Trophoblastic Tumor, Placental Site / Q000188:drug therapy* / Q000556:secondary*; D014594:Uterine Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D008727:Methotrexate