[Diagnosis and treatment of esophageal motility disorders].
Apart from gastroesophageal reflux disease, achalasia, non-cardiac chest pain and functional dysphagia are the most important manifestations of disturbed esophageal motility. Achalasia is characterized by esophageal aperistalsis and impaired deglutitive relaxation of the lower esophageal sphincter. The morphological correlate is a degeneration of nitrergic neurons in the myenteric plexus. Diagnosis is based on barium esophagram or esophageal manometry with the latter setting the gold standard. Endoscopic exclusion of a tumor at the gastroesophageal junction is mandatory. Appropriate therapeutic interventions are pneumatic dilatation or (laparoscopic myotomy) of lower esophageal sphincter. In patients unfit for these procedures endoscopic injection of botulinum toxin into the lower esophageal sphincter is appropriate. Non-cardiac chest pain may be of esophageal origin. Gastroesophageal reflux, spastic motility disorders and visceral hypersensitivity are arguable underlying mechanisms. The most important diagnostic procedure is 24 h esophageal pH metry correlating symptoms and reflux episodes. Proton pump inhibitors and tricyclic antidepressants serving as visceral analgesics are appropriate therapeutic approaches. Functional dysphagia defines the sensation of impaired passage without mechanical obstruction or a neuromuscular disease with known pathology, e.g. scleroderma. Impaired transit is proven by esophageal scintigraphy or radiogram both using solid boluses. Manometry assesses the underlying mechanisms.
Katschinski
M
M
Zentrum für Innere Medizin, Abteilung Gastroenterologie und Endokrinologie, Philipps-Universität, Marburg. Katschin@post.med.uni-marburg.de
D002637:Chest Pain / Q000188:drug therapy / Q000209:etiology*; D003680:Deglutition Disorders / Q000188:drug therapy / Q000209:etiology*; D003937:Diagnosis, Differential; D015154:Esophageal Motility Disorders / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D004947:Esophagus / Q000000981:diagnostic imaging / Q000601:surgery; D006801:Humans; D011859:Radiography