HIV-2 infection with cerebral toxoplasmosis and lymphomatoid granulomatosis.
A Nigerian man had acute onset of headache and vertigo due to a cerebellar mass. A brain biopsy of the mass revealed toxoplasmosis despite repeated negative HIV-1 serology. The presence of an opportunistic infection and his country of origin raised the suspicion for HIV-2; this was confirmed by positive HIV-2 serology. Despite his preliminary pathological diagnosis, results of physiological magnetic resonance imaging (MRI) (perfusion MRI and proton magnetic resonance spectroscopy) were not typical for toxoplasmosis. The lesion showed a biochemical and perfusion pattern that was intermediate for infectious and neoplastic processes. Further neuropathology confirmed a secondary diagnosis of lymphomatoid granulomatosis.
Issakhanian
M
M
Department of Neurology, University of California, Los Angeles (UCLA) School of Medicine, Harbor-UCLA Medical Center, Torrance, CA, USA.
Chang
L
L
Cornford
M
M
Witt
M
M
Speck
O
O
Goldberg
M
M
Ernst
T
T
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000473:pathology; D001921:Brain / Q000473:pathology; D002531:Cerebellum / Q000473:pathology; D003937:Diagnosis, Differential; D015658:HIV Infections / Q000175:diagnosis* / Q000473:pathology; D015498:HIV-2; D006801:Humans; D008230:Lymphomatoid Granulomatosis / Q000175:diagnosis* / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D016781:Toxoplasmosis, Cerebral / Q000175:diagnosis* / Q000473:pathology