HLA alleles in relation to specific immunity to liver stage antigen-1 from plasmodium falciparum in Gabon.
Cellular responses to synthetic peptides from the Liver Stage Antigen-1 (LSA-1) from Plasmodium falciparum were determined in 229 Gabonese children. HLA class I and II typing (by PCR-SSP and -RFLP, respectively) revealed that HLA-A*19, -B*17 (and -B*70), -DRB1*05, -DQA1*0102, -DQB1*0602 and -DPB1*0402 were the most frequent types or alleles at each locus. The DQB1*0201 and DQB1*0301 alleles were present at a higher frequency among IL-6 and IFN-gamma responders to the LSA-Rep and LSA-CTL peptides, respectively, and a higher proportion of these responders carried A*19 or B*53. The DRB1*06 type was positively related to the IL-10 production in response to the LSA-CTL peptide, and responders presented mainly A*2. The specificity A*10 was negatively associated with the cellular response to the LSA-J peptide. These results suggest a degree of genetic regulation of specific immune responses by HLA-A, operating at the pre-erythrocytic stage of development of P. falciparum in this Central African population.
Migot-Nabias
F
F
Centre International de Recherches Médicales de Franceville, Gabon, France.
Luty
A J
AJ
Minh
T N
TN
Fajardy
I
I
Tamouza
R
R
Marzais
F
F
Charron
D
D
Danzé
P M
PM
Renaut
A
A
Deloron
P
P
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D002648:Child; D005681:Gabon; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D016778:Malaria, Falciparum / Q000235:genetics / Q000276:immunology; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000276:immunology*
D000953:Antigens, Protozoan; D006680:HLA Antigens; C067302:liver stage-specific antigen, Plasmodium