title: Population genetic analysis of Colombian Trypanosoma cruzi isolates revealed by enzyme electrophoretic profiles.
abstract: Although Colombia presents an enormous biological diversity, few studies have been conducted on the population genetics of Trypanosoma cruzi. This study was carried out with 23 Colombian stocks of this protozoa analyzed for 13 isoenzymatic loci. The Hardy-Weinberg equilibrium, the genetic diversity and heterogeneity, the genetic relationships and the possible spatial structure of these 23 Colombian stocks of T. cruzi were estimated. The majority of results obtained are in agreement with a clonal population structure. Nevertheless, two aspects expected in a clonal structure were not discovered in the Colombian T. cruzi stocks. There was an absence of given zymodemes over-represented from a geographical point of view and the presumed temporal stabilizing selective phenomena was not observed either in the Colombian stocks sampled several times through the years of the study. Some hypotheses are discussed in order to explain the results found.
authors: Unidad de Genética (Genética de Poblaciones-Biología Evolutiva), Departamento de Biologia, Facultad de Ciencias, Pontifica Universidad Javerina, Bogotá DC, Colombia. mruiz@javercol.javerina.edu.co
authors: M
authors: M
authors: Ruiz-Garcia
authors: M
authors: M
authors: Montilla
authors: S
authors: S
authors: Nicholls
authors: D
authors: D
authors: Alvarez
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D000818:Animals; D003105:Colombia; D005260:Female; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D005819:Genetic Markers; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013037:Spatial Behavior; D014349:Trypanosoma cruzi / Q000201:enzymology / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D007527:Isoenzymes