[Extended-spectrum beta-lactamases (ESBLs) producing bacteria].
TEM- or SHV-type extended-spectrum beta-lactamases(ESBLs) are of clinical concern in Europe and the United States, whereas bacterial strains producing such types of ESBLs had not been reported in Japan for many years. Toho-1, a different type class A ESBL, has been reported in 1995, in which any prototypical enzyme has not been identified so far. At present Toho-1 is the major ESBL in Japan, however, SHV5 alpha has been reported in 1998, followed by TEM-26, SHV-2, and SHV12. More recently, SHV-24, a novel SHV-derived ESBL has also been found. Since Toho-1-type ESBL, AmpC-type beta-lactamase, and class B metallo-beta-lactamase have been widely found in Japan, a novel detection system for ESBLs suitable for this country should be developed.
Hirakata
Y
Y
Department of Laboratory Medicine, Nagasaki University School of Medicine.
D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology*; D006801:Humans; D018805:Sepsis / Q000382:microbiology; D013379:Substrate Specificity; D001618:beta-Lactamases / Q000096:biosynthesis*
D001618:beta-Lactamases