Atherogenesis and the arginine hypothesis.
In patients who have elevated levels of plasma ADMA, a relative deficiency of L-arginine has been found to contribute to the pathophysiology of athersclerosis, causing vasoconstriction, and accelerating atherogenesis. This finding--that there is a relative deficiency of L-arginine in atherosclerotic disease--is a breakthrough that will open new avenues of therapy.
Cooke
J P
JP
Section of Vascular Medicine, Stanford University School of Medicine, CVRB Section, Floor South, Stanford, CA, 94305-5406, USA. John.Cooke@stanford.edu
Oka
R K
RK
D001120:Arginine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000097:blood / Q000172:deficiency*; D004791:Enzyme Inhibitors / Q000097:blood; D006801:Humans; D009569:Nitric Oxide / Q000096:biosynthesis
D004791:Enzyme Inhibitors; D009569:Nitric Oxide; C018524:N,N-dimethylarginine; D001120:Arginine