Quantitative determination of the specific heat and the glass transition of moist samples by temperature modulated differential scanning calorimetry.
In differential scanning calorimetry (DSC), remnant moisture loss in samples often overlaps and distorts other thermal events, e.g. glass transitions. To separate such overlapping processes, temperature modulated DSC (TMDSC) has been widely used. In this contribution we discuss the quantitative determination of the heat capacity of a moist sample from TMDSC measurements. The sample was a spray-dried pharmaceutical compound run in different pans (hermetically-sealed pan, pierced lid pan [50 microm] and open pan). The apparent heat capacity was corrected for the remaining amount of moisture. Using this procedure we could clearly identify the glass transition of the dry and the moist sample. We found that a moisture content of about 6.2% shifts the glass transition by about 50 degrees C.
Schubnell
M
M
Mettler Toledo GmbH, Sonnenbergstrasse 74, CH-8603, Schwerzenbach, Switzerland. markus.schubnell@mt.com
Schawe
J E
JE
D002152:Calorimetry, Differential Scanning / Q000379:methods; D006358:Hot Temperature; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013818:Thermogravimetry; D014867:Water / Q000032:analysis*
D004364:Pharmaceutical Preparations; D014867:Water