Metabolism of N-isopropylacetanilide in rat.
1. Radioactivity from oral doses of N-isopropyl[1-14C]acetanilide was excreted in urine (53.5%), faeces (8.1%) and expired air (17.0%) of rat. 2. Enterohepatic circulation occurred during formation of approximately 34% of the metabolites. N-isopropylacetanilide was metabolized by oxidation in all moieties of the molecule with subsequent conjugation with glucuronic and sulphuric acids. 3. The sulphate ester of 4'-hydroxyacetanilide (acetaminophen) was the major metabolite (28 % of the dose).
Larsen
G L
GL
USDA ARS Biosciences Research Laboratory, Fargo, ND 58105, USA. larseng@fargo.ars.usda.gov
Feil
V J
VJ
Bakke
J E
JE
D000083:Acetanilides / Q000378:metabolism*; D000818:Animals; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D000083:Acetanilides; C433444:N-isopropylacetanilide; C011088:propachlor