1-Trifluoromethyl epoxy ethers. Effect of hexafluoro-2-propanol on reactions with secondary aromatic amines: synthesis of 3-trifluoromethyl indole derivatives.
Trifluoromethyl epoxy ethers 1 and 2 reacted with aromatic amines in hexafluoro-2-propanol at room temperature providing trifluoromethyl indolinols 3 and 4 in excellent isolated yields. 3-Trifluoromethyl indoles 9 and 10 could be prepared by treatment of indolinols with SOCl(2).
Rodrigues
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I
BIOCIS, Faculté de Pharmacie, rue J.B Clément, Châtenay-Malabry, F-92296 Cedex, France.
Bonnet-Delpon
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D
Bégué
J P
JP
D000588:Amines / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D007211:Indoles / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D020005:Propanols / Q000737:chemistry*; D006845:Hydrocarbons, Fluorinated
D000588:Amines; D004987:Ethers; D007211:Indoles; D020005:Propanols; C001337:hexafluoroisopropanol; D006845:Hydrocarbons, Fluorinated