title: Intraluminal modulation of gastric sensitivity to distension: effects of hydrochloric acid and meal.
abstract: Conscious sensations in response to gut distensions may be modulated by temporospatial interactions among different stimuli. This study investigated whether symptoms induced by gastric distension may be modified by hydrochloric acid (HCl) gastric infusion and meal ingestion. In nine healthy subjects, fixed pressure (isobaric) and fixed volume (isovolumetric) distensions were performed during continuous (4 ml/min) intragastric saline or HCl infusion, during fasting and after meal ingestion, until the maximal distension step defined as discomfort or a predefined maximal volume. During fasting isobaric distensions, the maximal distension step was significantly decreased during HCl compared with saline. The intragastric volumes were not significantly different, but the wall tension was significantly lower during HCl than saline. HCl increased gastric compliance. Meal ingestion relaxed the stomach and decreased the pressure at the maximal distension step during saline, but HCl did not further decrease it compared with fasting. During isovolumetric distensions, HCl also increased gastric compliance, but in both fasted and fed states it did not modify the maximal distension steps. In conclusion, sensations in response to gastric isobaric distensions, but not to isovolumetric distensions, are influenced by gastric acid infusion and meal ingestion. The effects of HCl might be related to a sensitization of mucosal mechanoreceptors.
authors: Gastroenterology Unit, Louis Mourier Hospital, 178 Rue des Renouillers, 92701 Colombes Cedex, France. benoit.coffin@lmr.ap-hop-paris.fr
authors: B
authors: B
authors: Coffin
authors: R
authors: R
authors: Chollet
authors: B
authors: B
authors: Flourié
authors: M
authors: M
authors: Lémann
authors: C
authors: C
authors: Franchisseur
authors: J C
authors: JC
authors: Rambaud
authors: R
authors: R
authors: Jian
mesh_terms: D000328:Adult; D004063:Digestion / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005215:Fasting / Q000502:physiology; D005260:Female; D006801:Humans; D006851:Hydrochloric Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007263:Infusions, Parenteral; D008297:Male; D019518:Postprandial Period / Q000502:physiology*; D011312:Pressure; D012016:Reference Values; D013270:Stomach / Q000187:drug effects / Q000502:physiology*
chemical_list: D006851:Hydrochloric Acid