[Prospect for the development of antibacterial agents with new mode of action].
Since there are no antibacterial agents to which there are no resistant bacteria, antibacterial agents with new mode of action are strongly demanded. Here, I describe the recent research for new targets and novel compounds that are active against the new targets. Proteins such as DnaA involved in DNA replication, deformylase and aminoacyl tRNA synthetase involved in protein synthesis, Mur peptide synthetases of peptidoglycan synthesis, FtsZ in cell division, two-component signaling system, quarum sensing system and efflux pumps are targeted and several inhibitors against deformylase, two-component signaling system and efflux pumps are reported. Unknown essential genes in bacteria are also explored in order to find new targets.
Iizawa
Y
Y
Pharmacology Research Laboratories II, Takeda Chemical Industries, Ltd.
D001419:Bacteria / Q000187:drug effects*; D001426:Bacterial Proteins / Q000096:biosynthesis; D002455:Cell Division / Q000187:drug effects; D002473:Cell Wall / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D001426:Bacterial Proteins