title: Irritation of gastrointestinal mucosa by new glycosyl derivative of diclofenac in comparison with diclofenac in rats.
abstract: We have obtained new glycosyl derivative of diclofenac 3 and studied its ulcerogenic effect in the gastrointestinal system. Diclofenac as free acid 1 and its derivative 3 were administered to rats per os in a single dose 20 mg/kg and in 5 doses of 5 mg/kg. Single dose of derivative 3 caused less irritation than 1; after multiple administration no irritating effect of derivative 3 was seen.
authors: Laborartory of Organic Chemistry, Institute of Chemistry, Chair of Pharmacology, Medical University of Łódź, 90-151 Łódź, 1 Muszyńskiego Str., Poland.
authors: J
authors: J
authors: Borowiecka
authors: W
authors: W
authors: Pakulska
authors: J
authors: J
authors: Graczyk
authors: M
authors: M
authors: Wagrowska-Danilewicz
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity*; D004008:Diclofenac / Q000031:analogs & derivatives / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D007509:Irritants / Q000633:toxicity*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007509:Irritants; D004008:Diclofenac