title: Cell and cytokine profiles in nasal secretions from patients with nasal polyposis: effects of topical steroids and surgical treatment.
abstract: BACKGROUND
  Nasal polyposis (NP), a chronic inflammatory disease of the paranasal sinus mucosa, is frequently associated with asthma. Previous reports showed that surgical treatment for nasal polyps may influence asthma evolution. We hypothesized that sinus surgery may alter the cytokine network in nasal secretions.
  
  
  METHODS
  We evaluated the characteristics (cells and mediators) of nasal lavages in nine patients with untreated NP (group A), 17 patients treated with topical steroids (group B), 21 patients treated by nasal surgery endonasal ethmoidectomy associated with topical steroids (group C), and 12 healthy subjects (controls).
  
  
  RESULTS
  Percentages of both eosinophils and neutrophils were higher in NP patients than in controls. Percentages of eosinophils and interleukin-5 (IL-5) level were higher in group A than in group C and controls. There was a positive correlation between IL-5 and eosinophils. In marked contrast, IL-8, IL-10, and IL-1beta levels were significantly higher in group C than in groups A and B and controls; TNF-alpha concentration was significantly lower in group C than in groups A and B and controls; and there was a negative correlation between IL-10 and TNF-alpha. The percentage of eosinophils was higher in asthmatic patients with NP than in nonasthmatic patients. In addition, in group C, asthmatic patients also had a significantly higher level of IL-10 than nonasthmatic patients.
  
  
  CONCLUSIONS
  Our study demonstrates that percentages of eosinophils and neutrophils, and IL-5 level were increased in nasal secretions from untreated patients with NP. Topical steroid treatment is associated with a decrease of inflammatory cells and mediators. In marked contrast, nasal surgery is associated with marked changes, in cytokine profile in nasal secretions, that are clearly different from those of controls and topical steroid-treated NP patients.
authors: Clinique des Maladies Respiratoires, H pital A Calmette, CHRU Lille, France.
authors: F
authors: F
authors: Bolard
authors: P
authors: P
authors: Gosset
authors: C
authors: C
authors: Lamblin
authors: C
authors: C
authors: Bergoin
authors: A B
authors: AB
authors: Tonnel
authors: B
authors: B
authors: Wallaert
mesh_terms: D000287:Administration, Topical; D000328:Adult; D002477:Cells / Q000187:drug effects* / Q000378:metabolism*; D016207:Cytokines / Q000187:drug effects* / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism* / Q000601:surgery; D009298:Nasal Polyps / Q000188:drug therapy / Q000601:surgery; D011446:Prospective Studies; D013256:Steroids / Q000008:administration & dosage / Q000627:therapeutic use
chemical_list: D016207:Cytokines; D013256:Steroids