title: Spindle cell variant of epithelioid sarcoma: an easily misdiagnosed tumour.
abstract: Epithelioid sarcoma is a histologically distinct soft tissue sarcoma of high grade malignancy. We report a case of epithelioid sarcoma in a young man who presented with multiple nodules over the left forearm, with bony invasion and pulmonary metastases. The histological features of the dermal tumour were those of a malignant spindle cell tumour with positive cytokeratin and vimentin staining and differed from the classical epithelioid sarcoma in its absence of typical necrobiotic nodular epithelioid pattern. It was the clinical presentation and the histology of the subcutaneous nodules that led to the final diagnosis of epithelioid sarcoma. This case illustrates a predominance of spindle cell pattern in the dermal tumour of epithelioid sarcoma, which has previously been reported as fibroma-like variant of epithelioid sarcoma.
authors: National Skin Centre, Singapore. shtan@nsc.gov.sg
authors: S H
authors: SH
authors: Tan
authors: B H
authors: BH
authors: Ong
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001132:Arm; D001707:Biopsy, Needle; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology*; D003937:Diagnosis, Differential; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D008297:Male; D012509:Sarcoma / Q000188:drug therapy / Q000473:pathology* / Q000556:secondary; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014057:Tomography, X-Ray Computed
chemical_list: D000970:Antineoplastic Agents