Lysosomal phospholipase A1 in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas' disease.
We found that, as in African trypanosomes, endogenous phospholipase A(1) (Plase A(1)) activity can catalyse extensive deacylation of phospholipids upon cell death in all life stages of Trypanosoma cruzi. A major lysosomal Plase A(1) was purified and characterized. The enzyme products can explain the lesions surrounding degenerating T. cruzi cells in host tissues. Thus Plase A(1) emerges as a target to block pathogenesis in trypanosomal infections.
Wainszelbaum
M
M
Department of Microbiology, University of Buenos Aires (UBA) School of Medicine, Paraguay 2155, piso 13, (RA-2111) Buenos Aires, Argentina.
Isola
E
E
Wilkowsky
S
S
Cannata
J J
JJ
Florin-Christensen
J
J
Florin-Christensen
M
M
D000818:Animals; D002384:Catalysis; D014355:Chagas Disease / Q000378:metabolism / Q000469:parasitology*; D006801:Humans; D008247:Lysosomes / Q000201:enzymology*; D010741:Phospholipases A / Q000302:isolation & purification / Q000378:metabolism* / Q000502:physiology; D054466:Phospholipases A1; D010743:Phospholipids / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000201:enzymology* / Q000472:pathogenicity
D010743:Phospholipids; D010741:Phospholipases A; D054466:Phospholipases A1