Changes in the T cell receptor macromolecular signaling complex and membrane microdomains during T cell development and activation.
Initiation and propagation of T cell receptor signaling pathways involves the mobilization and aggregation of a variety of signaling intermediates with the T cell receptor and associated molecules into specialized signaling complexes. Accumulating evidence suggests that differential regulation of the formation and composition of the T cell receptor macromolecular signaling complex may affect the different biological consequences of T cell activation. The regulatory mechanisms involved in the assembly of these complexes remains poorly understood, but in part is affected by the avidity of the T cell receptor ligand, co-stimulatory signals, and by the differentiation state of the T cell.
Leitenberg
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D
Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520-8011, USA.
Balamuth
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F
Bottomly
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K
D015704:CD4 Antigens / Q000276:immunology; D002454:Cell Differentiation; D006801:Humans; D017493:Leukocyte Common Antigens / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology*; D046911:Macromolecular Substances; D021962:Membrane Microdomains / Q000276:immunology*; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D015704:CD4 Antigens; D046911:Macromolecular Substances; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D011948:Receptors, Antigen, T-Cell; D017493:Leukocyte Common Antigens