Synthesis of 2-substituted trifluoromethylquinolines for the evaluation of leishmanicidal activity.
The synthesis of 2-substituted-trifluoromethylquinolines from aniline, trifluoromethylanilines, 3-aminoquinoline and trifluoromethylquinaldines is reported. In vitro antileishmanial evaluation of 2-alkyl, 2-alkenyl and 2-epoxypropyl-trifluoromethylquinolines is presented.
Dade
J
J
Laboratoire de Chimie organique, Faculté de Pharmacie, UPRES-A CNRS 8076, Université de Paris-Sud, Clément, Châtenay-Malabry, France.
Provot
O
O
Moskowitz
H
H
Mayrargue
J
J
Prina
E
E
D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002855:Chromatography, Thin Layer; D007202:Indicators and Reagents; D007891:Leishmania / Q000187:drug effects*; D007893:Leishmania donovani / Q000187:drug effects; D018314:Leishmania infantum / Q000187:drug effects; D007894:Leishmania mexicana / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D011804:Quinolines / Q000138:chemical synthesis* / Q000494:pharmacology*
D000981:Antiprotozoal Agents; D007202:Indicators and Reagents; D011804:Quinolines