[Biocompatibility assessment of aqueous extracts from new multiblock poly(ester-ester) copolymer].
In the Technical University of Szczecin, Department of Chemical Fibres and Physical Chemistry of Polymer there has been synthesised a new polymer based on butylene terephthalate--PBT and dimerized fatty acid--DFA. Five different polymers varying in mechanical properties depending on hard segments--PBT and soft segments--DFA composition were obtained. Assessment of biocompatibility of the new materials was conducted according to FDP. Prepared water extracts from polymers were applicated intravenously to mouse and intra-abdominaly to mice and guinea pigs. All animals survived spell of the experiment and no signs of physical degradation were noticed. Kidney, liver, spleen, heart and peritoneum specimens was taken and evaluated microscopically. There was no signs of toxic action of the extracts. Based on principles in FDP and the data from animal studies it is applicable that evaluated materials have no increased toxicity.
Prowans
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Klinika Chirurgii Ogólnej i Chirurgii Reki Pomorskiej Akademii Medycznej w Szczecinie.
el Fray
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M
Jursa
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J
Walaszek
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I
D000818:Animals; D001672:Biocompatible Materials; D006168:Guinea Pigs; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008422:Materials Testing; D051379:Mice; D011091:Polyesters / Q000633:toxicity*
D001672:Biocompatible Materials; D011091:Polyesters; C041733:poly(1,4-butylene terephthalate)