Vancomycin and ceftazidime bioactivities persist for at least 2 weeks in the lumen in ports: simplifying treatment of port-associated bloodstream infections by using the antibiotic lock technique.
The residual antibiotic concentration of vancomycin (2 mg/ml)- or ceftazidime (2 mg/ml)-heparin solutions instilled in ports in pediatric hematology-oncology patients 1 to 34 days earlier was measured. Antibiotic concentrations of > or = 100 microg of either antibiotic per ml persisted for at least 21 days. For treatment of lumenal port infections, antibiotic-heparin dwell times of > or = 2 weeks may be appropriate.
Haimi-Cohen
Y
Y
Divisions of Infectious Diseases, Department of Pediatrics, Long Island Jewish Medical Center of the North Shore-Long Island Jewish Medical Center Health System, Albert Einstein College of Medicine, New Hyde Park, New York 11040, USA.
Husain
N
N
Meenan
J
J
Karayalcin
G
G
Lehrer
M
M
Rubin
L G
LG
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000097:blood / Q000627:therapeutic use*; D002408:Catheters, Indwelling / Q000382:microbiology*; D002442:Ceftazidime / Q000097:blood / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D016459:Prosthesis-Related Infections / Q000097:blood / Q000188:drug therapy*; D014640:Vancomycin / Q000097:blood / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D014640:Vancomycin; D002442:Ceftazidime