Synthetic analogues of netropsin and distamycin. VI. Synthesis of carbocyclic lexitropsins containing a bioreductive element.
Carbocyclic derivatives of lexitropsines containing of two aromatic rings, N-dimethylaminopropyl group lonked to carboxyl terminus and 5-[bis(2-chloroethyl)-amino]-2,4-dinitrobenzamide group linked to the amino terminus group were synthesed. The N-terminal group should present selective alkylating activity on the DNA of cancer cells in conditions of hypoxia.
Markowska
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Department of Organic Chemistry, Medical Academy of Białystok.
Rózański
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D000478:Alkylation; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D015687:Cell Hypoxia; D004273:DNA, Neoplasm / Q000378:metabolism; D004214:Distamycins / Q000138:chemical synthesis*; D009429:Netropsin / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D010084:Oxidation-Reduction
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D004214:Distamycins; C053654:lexitropsin; D009429:Netropsin; C030000:stallimycin