title: Aggressive digital papillary adenocarcinoma: a case report and review of the literature.
abstract: We report a case of an aggressive digital papillary adenocarcinoma (ADPA) on the right thumb of a 48-year-old white man. Histologic evaluation of the initial biopsy demonstrated features consistent with those proposed for aggressive digital papillary adenoma; however, re-excision of the remaining lesion revealed histologic features consistent with aggressive digital papillary adenocarcinoma. These tumors have a high rate of local recurrence and can metastasize, occasionally resulting in mortality. Our case demonstrates that even if the histologic criteria of aggressive digital papillary adenocarcinoma are met, the lesion may still represent an aggressive digital papillary adenocarcinoma (ADPAca). In agreement with a recent study by Duke et al., this case supports the idea that aggressive digital papillary lesions should be classified as aggressive digital papillary adenocarcinoma.
authors: Department of Dermatology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA.
authors: D M
authors: DM
authors: Jih
authors: R
authors: R
authors: Elenitsas
authors: C C
authors: CC
authors: Vittorio
authors: A R
authors: AR
authors: Berkowitz
authors: J T
authors: JT
authors: Seykora
mesh_terms: D000231:Adenocarcinoma, Papillary / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D000236:Adenoma / Q000175:diagnosis; D002272:Carcinoembryonic Antigen / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D013933:Thumb / Q000473:pathology
chemical_list: D002272:Carcinoembryonic Antigen; D009418:S100 Proteins; D007633:Keratins