Sesaminol from sesame seed induces apoptosis in human lymphoid leukemia Molt 4B cells.
The exposure of human lymphoid leukemia Molt 4B cells to sesaminol, a component of sesame oil led to both growth inhibition and the induction of apoptosis. Morphological change showing apoptotic bodies was observed in the cells treated with sesaminol. The fragmentation of DNA by sesaminol to oligonucleosomal-sized fragments that are characteristics of apoptosis was observed to be concentration- and time-dependent. These findings suggest that growth inhibition of Molt 4B cells by sesaminol results from the induction of apoptosis in the cells.
Miyahara
Y
Y
Kuki Sangyo Co., Ltd., Yokkaichi-city, Mie 510-0059, Japan.
Hibasami
H
H
Katsuzaki
H
H
Imai
K
K
Osawa
T
T
Ina
K
K
Komiya
T
T
D017209:Apoptosis / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects; D053938:DNA Fragmentation / Q000187:drug effects; D004273:DNA, Neoplasm / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D004149:Dioxoles / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005663:Furans / Q000494:pharmacology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000473:pathology*; D012715:Sesame Oil / Q000737:chemistry; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm; D004149:Dioxoles; D005663:Furans; C066016:sesaminol; D012715:Sesame Oil