Placental transfer of the antioxidant stobadine at different gestational stages in rabbits.
The distribution of [3H]-stobadine, a pyridoindole antioxidant, was investigated in New Zealand white rabbits and their fetuses on days 20 and 27 of gestation. The concentrations of [3H]-stobadine were determined in maternal and fetal organs after oral administration in a single dose of 5.0 mg/kg. The results of the study showed that during the late period of gestation the fetal organs, especially the brain and heart, were under the protective action of the antioxidant stobadine.
Ujházy
E
E
Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava, Slovak Republic. exfadubm@savba.sk
Dubovický
M
M
Faberová
V
V
Zemánek
M
M
Soltés
L
L
Gajdosík
A
A
Eybl
V
V
D000818:Animals; D000975:Antioxidants / Q000493:pharmacokinetics*; D002243:Carbolines / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution
D000975:Antioxidants; D002243:Carbolines; C100106:dicarbine