High phosphorus intake only slightly affects serum minerals, urinary pyridinium crosslinks and renal function in young women.
OBJECTIVE
Assessment of the physiological effects of a diet rich in phosphorus in young women.


METHODS
Control period I--commercial basic diet containing 1700 mg P and 1500 mg Ca/day for 4 weeks. Supplementation period--a 6 week high-phosphorus period of 3008 mg P and 1995 mg Ca/day. Control period II--4 weeks washout with basic diet as in period I.


METHODS
Institute of Nutritional Science, Friedrich Schiller University, Jena.


METHODS
Ten healthy women, aged 20-30y.


METHODS
Orange juice and tablets, containing supplements of Ca5(PO4)3OH and NaH2PO4, totalling 1436 mg elemental phosphorus per day.


RESULTS
There was an increase of 10.7+/-13.7 pg/ml in serum PTH, a decrease of 0.6+/-0.6 ng/ml in serum osteocalcin, an increase of 73.6+/-136.6 nmol/mmol creatinine in urinary pyridinoline and of 19.3+/-36.0 nmol/ mmol creatinine in urinary deoxypyridinoline, and a decrease of 2.6+/-9.3 mg/l in urinary microalbumin. All changes were insignificant. There were no changes in serum levels of Ca, PO4 or Zn, in serum concentration of 1,25-(OH)2D3, and in urinary beta-2-microglobulin excretion. Phosphorus supplementation caused intestinal distress, soft stools or mild diarrhoea.


CONCLUSIONS
In spite of a high phosphorus supplementation no significant changes in bone-related hormones, pyridinium crosslinks as markers of bone resorption and parameters of renal function in young women were found.
Grimm
M
M
Friedrich Schiller University, Institute of Nutritional Science, Jena, Germany. b6grma@rz.uni-jena.de
Müller
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Hein
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Fünfstück
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Jahreis
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D000328:Adult; D000418:Albumins / Q000032:analysis; D015415:Biomarkers / Q000097:blood; D001842:Bone and Bones / Q000378:metabolism; D002136:Calcium, Dietary / Q000008:administration & dosage; D019587:Dietary Supplements; D005260:Female; D006801:Humans; D007668:Kidney / Q000502:physiology*; D008903:Minerals / Q000097:blood* / Q000378:metabolism; D015675:Osteocalcin / Q000097:blood; D016226:Phosphorus, Dietary / Q000008:administration & dosage* / Q000378:metabolism; D011726:Pyridinium Compounds / Q000652:urine*
D000418:Albumins; D015415:Biomarkers; D002136:Calcium, Dietary; D008903:Minerals; D016226:Phosphorus, Dietary; D011726:Pyridinium Compounds; D015675:Osteocalcin