Growth control: invertebrate insulin surprises!
Recent work on Drosophila has provided new insights into how insulin signalling - conserved in mammals, flies and worms - regulates growth and cell division during development. Invertebrates have been found to possess more insulin-like ligands than predicted, some of which behave as receptor antagonists.
Leevers
S J
SJ
Ludwig Institute for Cancer Research, 91 Riding House Street, W1W 7BS, London, UK. sallyl@ludwig.ucl.ac.uk
D000818:Animals; D006801:Humans; D017173:Caenorhabditis elegans; D029742:Caenorhabditis elegans Proteins; D004330:Drosophila / Q000254:growth & development; D005123:Eye / Q000166:cytology / Q000254:growth & development; D015801:Helminth Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D007328:Insulin / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D007448:Invertebrates; D008024:Ligands; D010455:Peptides; D011972:Receptor, Insulin / Q000037:antagonists & inhibitors / Q000235:genetics / Q000378:metabolism / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology
D029742:Caenorhabditis elegans Proteins; C107483:DAF-2 protein, C elegans; D015801:Helminth Proteins; C424903:ins-1 protein, C elegans; D007328:Insulin; D008024:Ligands; D010455:Peptides; D011972:Receptor, Insulin