title: Nuclear factor-kappaB activation is higher in peripheral blood mononuclear cells of male smokers.
abstract: Nuclear factor-kappaB (NF-kappaB) is an oxidative stress sensitive transcription factor involved in the regulation of inflammatory genes. Activation of NF-kappaB results into increased expression of inflammatory genes such as for interleukins, endothelial cell leukocyte adhesion molecules and inducible NO synthase. Our study, with six smokers and 10 non-smokers, showed that NF-kappaB activity in peripheral blood mononuclear cells of smokers compared to non-smokers is significantly higher (P<0.05). This indicates that NF-kappaB is involved in cigarette smoke induced inflammatory responses and that NF-kappaB activation can be used as a functional marker of oxidative stress.
authors: TNO Nutrition and Food Research, Department of Nutritional Physiology, Utrechtseweg 48, PO Box 360, 3700 AJ, Zeist, The Netherlands
authors: R
authors: R
authors: van den Berg
authors: G R.M.M.
authors: GR
authors: Haenen
authors: H
authors: H
authors: van den Berg
authors: A
authors: A
authors: Bast