Fatal liver failure due to ketoconazole treatment of a girl with Cushing's syndrome.
A patient is reported who developed fatal liver failure on ketoconazole treatment for Cushing's syndrome. It is recommended that metyrapone be used when hypercortisolism has to be controlled as a temporary measure in childhood and adolescence.
Zöllner
E
E
Department of Paediatrics, University of Cape Town, South Africa. ezollner@ich.uct.ac.za
Delport
S
S
Bonnici
F
F
D000293:Adolescent; D003480:Cushing Syndrome / Q000188:drug therapy*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000009:adverse effects*; D017093:Liver Failure / Q000139:chemically induced*; D008111:Liver Function Tests
D007654:Ketoconazole