Mitochondrial DNA alteration in esophageal cancer.
It has been reported that various cancers frequently have mutations in the D-loop region of mitochondrial DNA (mtDNA). We examined the genetic alterations in this region of esophageal cancer using direct sequencing. Of 68 sequence variants, 15 have not been reported to date. Tumor mtDNA with these variants were compared with mtDNA from corresponding normal esophageal mucosa. Two of 37 primary esophageal cancers (5%) contained somatic mutations in the D-loop region of mtDNA. Although the mutation rate of mitochondrial tumor DNA within the D-loop was not high, this result suggested that mtDNA mutations play a role in the development of esophageal cancer.
Hibi
K
K
Second Department of Surgery, Nagoya University School of Medicine, Nagoya, Japan. khibi@tsuru.med.nagoya-u.ac.jp
Nakayama
H
H
Yamazaki
T
T
Takase
T
T
Taguchi
M
M
Kasai
Y
Y
Ito
K
K
Akiyama
S
S
Nakao
A
A
D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000032:analysis / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis; D004938:Esophageal Neoplasms / Q000235:genetics*; D006801:Humans; D009154:Mutation; D009690:Nucleic Acid Conformation; D017422:Sequence Analysis, DNA
D004272:DNA, Mitochondrial; D004273:DNA, Neoplasm