title: Piperine inhibits gastric emptying and gastrointestinal transit in rats and mice.
abstract: Piperine (1), an alkaloid of black and long peppers, inhibited gastric emptying (GE) of solids/liquids in rats and gastrointestinal transit (GT) in mice in a dose and time dependent manner. Compound 1 significantly inhibited GE of solids and GT at the doses extrapolated from humans (1 mg/kg and 1.3 mg/kg p.o. in rats and mice, respectively). However, at the same dose the effect was insignificant for GE of liquids. One week oral treatment of 1 mg/kg and 1.3 mg/kg in rats and mice, respectively, did not produce a significant change in activity as compared to single dose administration. GE inhibitory activity of 1 is independent of gastric acid and pepsin secretion.
authors: S
authors: S
authors: Bajad
authors: K L
authors: KL
authors: Bedi
authors: A K
authors: AK
authors: Singla
authors: R K
authors: RK
authors: Johri
mesh_terms: D000470:Alkaloids; D000818:Animals; D052117:Benzodioxoles; D004064:Digestive System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D010880:Piperidines / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry; D053284:Polyunsaturated Alkamides; D051381:Rats
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D010936:Plant Extracts; D053284:Polyunsaturated Alkamides; C018620:oleoresins; C008922:piperine