Regulation of T-cell apoptosis in inflammatory bowel disease: to die or not to die, that is the mucosal question.
T-cell resistance against apoptosis contributes to inappropriate T-cell accumulation and the perpetuation of chronic mucosal inflammation in inflammatory bowel diseases (IBDs). Anti-interleukin-12 (IL-12) and anti-IL-6 receptor antibodies suppress colitis activity by the induction of T-cell apoptosis. These findings have important implications for the design of effective treatment regimens in IBD.
Neurath
M F
MF
Laboratory of Immunology, I. Medical Clinic, University of Mainz, 55131, Mainz, Germany. neurath@1-med.klinik.uni-mainz.de
Finotto
S
S
Fuss
I
I
Boirivant
M
M
Galle
P R
PR
Strober
W
W
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D016923:Cell Death / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D015212:Inflammatory Bowel Diseases / Q000276:immunology* / Q000473:pathology*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology*