Membrane fluidity correlates with liver cancer cell proliferation and infiltration potential.
We developed a method to measure membrane fluidity of living cancer cells in two- and three-dimensional cultures, and found that there was a close relationship between the membrane fluidity of cancer cells and their proliferative and infiltrative ability. Membrane fluidity is thus a promising indicator of the probability of cancer recurrence.
Funaki
N O
NO
Department of Surgery, Shiga Medical Center for Adults, Moriyama City, Japan.
Tanaka
J
J
Kohmoto
M
M
Sugiyama
T
T
Ohshio
G
G
Nonaka
A
A
Yotsumoto
F
F
Takeda
Y
Y
Imamura
M
M
D001973:Bromodeoxyuridine; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002455:Cell Division; D002462:Cell Membrane / Q000502:physiology*; D005454:Fluorescence Polarization; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008560:Membrane Fluidity; D008858:Microscopy, Phase-Contrast; D008954:Models, Biological; D014407:Tumor Cells, Cultured
D001973:Bromodeoxyuridine