title: In vitro biological activity of prenylflavanones.
abstract: The biological activity of ten prenylflavanones purified from Sophora tomentosa L., and Sophora moorcroftiana Benth. ex Baker (Leguminosae) was investigated. The flavanones with prenyl-, lavandulyl- or geranyl groups on A ring, and two bioactive flavonostilbenes on ring B and stilbene (resveratrol) showed tumor-specific cytotoxic activity, antimicrobial activity, and anti-HIV activity, radical generation, and O2- scavenging activity. There was a positive relationship between radical generation and O2- scavenging activity in these prenylflavanones. These data suggest the medicinal significance of prenylflavanones.
authors: Faculty of Pharmaceutical Sciences, Josai University, 1-1 Keyakidai, Sakado, Saitama 350-0295, Japan. shiratak@josai.ac.jp
authors: Y
authors: Y
authors: Shirataki
authors: N
authors: N
authors: Motohashi
authors: S
authors: S
authors: Tani
authors: H
authors: H
authors: Sakagami
authors: K
authors: K
authors: Satoh
authors: H
authors: H
authors: Nakashima
authors: S K
authors: SK
authors: Mahapatra
authors: K
authors: K
authors: Ganguly
authors: S G
authors: SG
authors: Dastidar
authors: A N
authors: AN
authors: Chakrabarty
mesh_terms: D019380:Anti-HIV Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002460:Cell Line; D004354:Drug Screening Assays, Antitumor; D004578:Electron Spin Resonance Spectroscopy; D005419:Flavonoids / Q000494:pharmacology*; D016166:Free Radical Scavengers / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010946:Plants, Medicinal; D013481:Superoxides / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D019380:Anti-HIV Agents; D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D005419:Flavonoids; D016166:Free Radical Scavengers; D013481:Superoxides