Topical anti-inflammatory activity of some Asian medicinal plants used in dermatological disorders.
The topical anti-inflammatory activity of extracts from Cassia angustifolia, Rheum palmatum, Coptis chinensis, Phellodendron amurense and Scutellaria baicalensis, plants used in traditional East Asian medicine against different skin disorders, was studied. Though in different degree, all the extracts significantly inhibited the edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA), in both single or multiple application, oxazolone, and arachidonic acid (AA). None of the extracts inhibited in vitro the activity of phospholipase A(2) (PLA(2)) from Naja naja.
Cuéllar
M J
MJ
Departament de Farmacologia, Facultat de Farmàcia, Universitat de València, Avda. Vicent Andrés Estellés, s/n. 46100 Burjassot, Valencia, Spain.
Giner
R M
RM
Recio
M C
MC
Máñez
S
S
Ríos
J L
JL
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D051379:Mice; D010081:Oxazolone; D010741:Phospholipases A / Q000187:drug effects*; D010946:Plants, Medicinal; D019664:Polygonaceae; D019685:Rosales
D000893:Anti-Inflammatory Agents; D004365:Drugs, Chinese Herbal; D010081:Oxazolone; D010741:Phospholipases A