Dietary oleoyl-estrone delays the growth rate of young rats.
BACKGROUND
Oleoyl-estrone administration induces the rapid loss of fat preserving body protein.


OBJECTIVE
We intended to check whether the fat-shedding effect of oleoyl-estrone arrests growth in young rats, limiting the buildup of protein and fat.


METHODS
Oleoyl-estrone diluted in a powdered hyperlipidic diet (33 mumol/kg) was given for 30 days to 30-day old Zucker lean (Fa/?) rats. Their body weight and food consumption were followed daily; on day 30 of treatment (60-day old rats), whole body composition (lipid, protein) was determined, and plasma energy parameters and leptin were measured.


RESULTS
Oleoyl-estrone-treated rats grew more slowly than controls fed the hyperlipidic diet alone, and on day 60 their lipid content was about half that of controls. Protein content per kg was identical in both groups, but treated rats tended to accumulate less nitrogen and energy because of their smaller size. No changes in plasma glucose, urea, triacylglycerols or total cholesterol were observed, but oleoyl-estrone-treated rats showed lower circulating leptin than controls.


CONCLUSIONS
Despite limiting the accumulation of lipids, oleoyl-estrone slowed, but did not arrest growth of young rats, nor elicit a loss of fat or protein.
Tang
V
V
Centre Especial de Recerca en Nutrició i Ciència dels Aliments Departament de Bioquímica i Biologia Molecular, Facultat de Biologia, Universitat de Barcelona Av. Diagonal, 645 08028 Barcelona, Spain.
Torregrosa
C
C
Remesar
X
X
Alemany
M
M
D000818:Animals; D019440:Anti-Obesity Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D002149:Energy Intake / Q000187:drug effects*; D004734:Energy Metabolism / Q000187:drug effects; D004970:Estrone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D006128:Growth / Q000187:drug effects*; D020738:Leptin / Q000097:blood; D009584:Nitrogen / Q000378:metabolism; D009829:Oleic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011924:Rats, Zucker
D019440:Anti-Obesity Agents; D020738:Leptin; D009829:Oleic Acids; D004970:Estrone; C108709:oleoyl-estrone; D009584:Nitrogen