title: Persistence of human immunodeficiency virus type 1-specific cytotoxic T-lymphocyte clones in a subject with rapid disease progression.
abstract: We longitudinally measured T-cell receptor transcript frequencies of human immunodeficiency virus type 1 (HIV-1) specific cytotoxic T lymphocytes (CTL) in an individual with rapidly progressive disease and high levels of viremia. CTL clones elicited during acute HIV-1 infection were present at the time of death, despite absent functional CTL responses, arguing against clonal deletion as a mechanism for the decline of CTL responses observed during HIV-1 infection.
authors: Partners AIDS Research Center & ID Division, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 02114, USA.
authors: S A
authors: SA
authors: Islam
authors: C M
authors: CM
authors: Hay
authors: K E
authors: KE
authors: Hartman
authors: S
authors: S
authors: He
authors: A K
authors: AK
authors: Shea
authors: A K
authors: AK
authors: Trocha
authors: M J
authors: MJ
authors: Dynan
authors: N
authors: N
authors: Reshamwala
authors: S P
authors: SP
authors: Buchbinder
authors: N O
authors: NO
authors: Basgoz
authors: S A
authors: SA
authors: Kalams
mesh_terms: D002908:Chronic Disease; D002999:Clone Cells; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D008137:Longitudinal Studies; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics* / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D013997:Time Factors
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta