Patient-specific cytotoxic T-lymphocyte cross-recognition of naturally occurring variants of a human immunodeficiency virus type 1 (HIV-1) p24gag epitope by HIV-1-infected children.
We tested seven human immunodeficiency virus-infected children for their cytotoxic T-lymphocyte (CTL) activities towards the p24gag QASQEVKNW epitope and its nine variant sequences. Our data confirm that most, but not all, CTL responses are broadly cross-specific. For the first time, we show the high interpatient variability in cross-recognition of mutant CTL epitopes. These interindividual variations in the CTL response to the same epitope should be taken into account in the design and the evaluation of vaccines.
Buseyne
F
F
Laboratoire d'Immunopathologie Virale, URA CNRS 1930, Institut Pasteur, Hôpital Necker-Enfants Malades, 75015 Paris, France. florence@pasteur.fr
Chaix
M L
ML
Rouzioux
C
C
Blanche
S
S
Rivière
Y
Y
D002648:Child; D003429:Cross Reactions; D018984:Epitopes, T-Lymphocyte / Q000276:immunology*; D014644:Genetic Variation; D016655:HIV Core Protein p24 / Q000276:immunology*; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D015235:HLA-B Antigens / Q000276:immunology; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008213:Lymphocyte Activation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D018984:Epitopes, T-Lymphocyte; D016655:HIV Core Protein p24; D006680:HLA Antigens; D015235:HLA-B Antigens; C078438:HLA-B53 antigen; C103707:HLA-B57 antigen