title: A search for new glucophores by isosteric replacement of carboxylic function.
abstract: We used arylsulfonylalkanoic acids as parent structures for designing new potential sweeteners. The Kohonen maps of the molecular electrostatic potential of the possible bioisosteric replacements of carboxylic function have been simulated and used for the selection of the potential synthetic targets which are now under synthesis.
authors: Department of Organic Chemistry, Institute of Chemistry, University of Silesia, PL-40-006 Katowice, Poland. Polanski@us.edu.pl
authors: J
authors: J
authors: Polański
authors: K
authors: K
authors: Jarzembek
authors: V
authors: V
authors: Łysiak
mesh_terms: D015195:Drug Design; D016571:Neural Networks, Computer; D055672:Static Electricity; D013549:Sweetening Agents / Q000138:chemical synthesis*; D013649:Taste
chemical_list: D013549:Sweetening Agents