title: Serum uric acid and renal prognosis in patients with IgA nephropathy.
abstract: OBJECTIVE
  This study was designed to elucidate the clinical significance of serum uric acid (SUA) and the relationship between hyperuricemia and renal prognosis in IgA nephropathy.
  
  
  METHODS
  The correlation between SUA and other clinical parameters were examined in 748 IgA nephropathy patients (432 males and 316 females). Among these patients, 226 (144 males and 82 females) who were followed for more than 5 years were examined for the relationship between hyperuricemia and renal prognosis.
  
  
  RESULTS
  In IgA nephropathy, SUA correlated negatively with creatinine clearance (Ccr), and positively with urinary protein and tubulointerstitial damage. SUA was higher in patients with hypertension or diffuse proliferative glomerulonephritis. Hyperuricemia was a risk factor for renal prognosis, both in terms of serum creatinine (p = 0.0025) and Ccr (p = 0.0057). In 56 patients with normal Ccr at renal biopsy, the change of Ccr after more than 8 years was -22.3 +/- 20.8% in 13 patients with hyperuricemia, compared with +2.6 +/- 39.4% in 43 patients without hyperuricemia (p = 0.0238). Hyperuricemia was related independently to deterioration of Ccr (p = 0.0461).
  
  
  CONCLUSIONS
  Hyperuricemia in IgA nephropathy is derived from both glomerular and tubulointerstitial damage, and correlated with hypertension. Hyperuricemia is a risk factor for renal prognosis in IgA nephropathy.
authors: Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan. i-ohno@zc4.so-net.ne.jp
authors: I
authors: I
authors: Ohno
authors: T
authors: T
authors: Hosoya
authors: H
authors: H
authors: Gomi
authors: K
authors: K
authors: Ichida
authors: H
authors: H
authors: Okabe
authors: M
authors: M
authors: Hikita
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001706:Biopsy; D003404:Creatinine / Q000097:blood / Q000378:metabolism; D005260:Female; D005922:Glomerulonephritis, IGA / Q000097:blood* / Q000503:physiopathology*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D011379:Prognosis; D012044:Regression Analysis; D014527:Uric Acid / Q000097:blood*
chemical_list: D015415:Biomarkers; D014527:Uric Acid; D003404:Creatinine