Immunotherapeutic gene transfer into muscle.
Immuno-gene therapy can be advantageously performed with nonviral approaches. Genes that encode regulatory cytokines or inflammatory cytokine inhibitors can be delivered intramuscularly and expressed for weeks or months. This type of gene transfer into muscle has been shown to ameliorate several autoimmune diseases and is relevant to the development of effective DNA vaccines in autoimmune diseases, infectious diseases and cancer.
Prud'homme
G J
GJ
Department of Pathology, McGill University, 3775 University St, Rm B13, Montreal, H3A2B4., Quebec, Canada. gprudh@po-box.mcgill.ca
Lawson
B R
BR
Chang
Y
Y
Theofilopoulos
A N
AN
D000818:Animals; D017951:Antigen Presentation; D015551:Autoimmunity / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D016207:Cytokines / Q000235:genetics / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000517:prevention & control; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007167:Immunotherapy / Q000379:methods*; D007273:Injections, Intramuscular; D008177:Lupus Vulgaris / Q000276:immunology / Q000628:therapy; D018482:Muscle, Skeletal; D019444:Vaccines, DNA / Q000008:administration & dosage
D016207:Cytokines; D019444:Vaccines, DNA; D003165:Complement System Proteins