Severe congenital cytomegalovirus infection with fetal hydrops in a cytomegalovirus-seropositive healthy woman.
We report the case of a woman whose two consecutive pregnancies resulted in intrauterine fetal death due to severe congenital cytomegalovirus infection. In both pregnancies, congenital cytomegalovirus infection was prenatally diagnosed on the basis of detection of cytomegalovirus DNA and specific IgM in cord blood. This case suggests that severe congenital cytomegalovirus infection can occur even in seropositive healthy women.
Inoue
T
T
Department of Gynecology and Obstetrics, Faculty of medicine, Kyoto University, Graduate School of Medicine, Shogoin Kawahara-cho 54, Sakyo-ku, 606-8507, Kyoto, Japan. inoue@kuhp.kyoto-u.ac.jp
Matsumura
N
N
Fukuoka
M
M
Sagawa
N
N
Fujii
S
S
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D003587:Cytomegalovirus / Q000235:genetics / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000151:congenital*; D004279:DNA, Viral / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005313:Fetal Death / Q000821:virology; D005315:Fetal Diseases / Q000821:virology*; D005865:Gestational Age; D006801:Humans; D015160:Hydrops Fetalis / Q000821:virology*; D007075:Immunoglobulin M / Q000097:blood; D011247:Pregnancy; D012008:Recurrence
D000914:Antibodies, Viral; D004279:DNA, Viral; D007075:Immunoglobulin M