Property-based design: optimization of drug absorption and pharmacokinetics.
van De Waterbeemd
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Department of Drug Metabolism, Pfizer Global Research and Development, Sandwich Laboratories, Sandwich, Kent CT13 9NJ, UK. han_waterbeemd@sandwich.pfizer.com
Smith
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DA
Beaumont
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Walker
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DK
D000818:Animals; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism; D001812:Blood-Brain Barrier; D018938:Caco-2 Cells; D002462:Cell Membrane / Q000378:metabolism; D015195:Drug Design; D005123:Eye / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D008954:Models, Biological; D008958:Models, Molecular; D009297:Nasal Mucosa / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010599:Pharmacokinetics; D011355:Prodrugs / Q000378:metabolism; D012869:Skin Absorption
D001798:Blood Proteins; D004364:Pharmaceutical Preparations; D011355:Prodrugs