[Therapeutic monitoring by blood concentrations with the focus on cyclosporin A].
Cyclosporin A therapeutic drug monitoring with through concentrations results in a high frequency of toxicity or therapeutic failure. There is no simple relation between the through and the mean concentration, and thus the therapeutic effect. Estimation of the AUC on sparse sampling or population pharmacokinetic analysis and the Bayesian fit of the parameters are discussed.
Jensen
S A
SA
H:S Rigshospitalet, klinisk farmakologisk afdeling Q. sastrup@rh.dk
Dalhoff
K P
KP
D001499:Bayes Theorem; D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D016903:Drug Monitoring / Q000379:methods; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics
D007166:Immunosuppressive Agents; D016572:Cyclosporine