Indices of nitric oxide synthesis and outcome in critically ill patients.
We measured the concentrations of serum nitrates/nitrites and plasma cyclic guanosine monophosphate as markers of nitric oxide synthesis in patients with or without septic shock for 5 days following admission to intensive care. We found that nitrate/nitrite concentrations, when corrected for the effect of renal failure, were significantly higher in patients with septic shock, both on admission and in the final samples drawn. In a logistic regression analysis, the rate of change of nitrate/nitrite concentration was associated with survival to day 28 (falling in survivors). The concentration of cyclic guanosine monophosphate when corrected for the confounding effects of renal function and platelet count, was only associated with the septic shock group on admission.
MacKenzie
I M
IM
Nuffield Department of Anaesthetics, Radcliffe Infirmary, Oxford OX2 6HE, UK. IMacke2690@aol.com
Garrard
C S
CS
Young
J D
JD
D018806:APACHE; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003422:Critical Care; D006152:Cyclic GMP / Q000097:blood; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009566:Nitrates / Q000097:blood; D009569:Nitric Oxide / Q000096:biosynthesis*; D009573:Nitrites / Q000097:blood; D011379:Prognosis; D012772:Shock, Septic / Q000097:blood*; D015996:Survival Rate
D015415:Biomarkers; D009566:Nitrates; D009573:Nitrites; D009569:Nitric Oxide; D006152:Cyclic GMP