title: Randomized trial of adjuvant chemotherapy versus control after curative resection for gastric cancer: 5-year follow-up.
abstract: Adjuvant chemotherapy of gastric cancer after curative resection is still subject to discussion. In this study 137 patients with gastric adenocarcinoma, all with positive nodes, were randomized after curative resection so that 69 received epidoxorubicin (EPI), leucovorin (LV) and 5-fluorouracil (5-FU) on days 1-3 every 3 weeks for 7 months, whereas the remaining 68 did not. After a follow-up period of 5 years, 21 of the 69 treated patients (30%) and nine controls (13%) were still alive; median survival time was 18 months for the controls and 31 months for the patients treated with adjuvant chemotherapy (P< 0.01).
authors: Department of Internal Medicine and Oncological Day Hospital, University of Florence, Italy.
authors: B
authors: B
authors: Neri
authors: G
authors: G
authors: Cini
authors: F
authors: F
authors: Andreoli
authors: B
authors: B
authors: Boffi
authors: D
authors: D
authors: Francesconi
authors: R
authors: R
authors: Mazzanti
authors: F
authors: F
authors: Medi
authors: A
authors: A
authors: Mercatelli
authors: S
authors: S
authors: Romano
authors: L
authors: L
authors: Siliani
authors: R
authors: R
authors: Tarquini
authors: R
authors: R
authors: Moretti
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000601:surgery*; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015251:Epirubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005500:Follow-Up Studies; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000601:surgery*
chemical_list: D015251:Epirubicin; D002955:Leucovorin; D005472:Fluorouracil