Gabapentin-induced hypersensitivity syndrome.
Hypersensitivity syndrome is a rare but potentially fatal reaction to some pharmacologic agents, including some antiepileptic drugs. Typically, the syndrome presents with fever, rash, tender lymphadenopathy, hepatitis, and eosinophilia. We report a novel case of clinical hypersensitivity syndrome secondary to gabapentin. A patient developed altered mental status, fever, diffuse macular rash, and an enlarged spleen. This constellation of symptoms and signs began 9 days after gabapentin therapy was begun. Quick resolution was noted after gabapentin was discontinued. To our knowledge, there are no reports of hypersensitivity syndrome to gabapentin.
Ragucci
M V
MV
Department of Rehabilitation Medicine, Rusk Institute, New York University School of Medicine, New York, New York 10016, USA.
Cohen
J M
JM
D000085:Acetates / Q000009:adverse effects*; D000368:Aged; D000588:Amines; D000700:Analgesics / Q000009:adverse effects*; D003509:Cyclohexanecarboxylic Acids; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000503:physiopathology; D000077206:Gabapentin; D006801:Humans; D008297:Male; D013577:Syndrome; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000700:Analgesics; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin