Adenosine A2A receptor knockout mice are partially protected against drug-induced catalepsy.
Catalepsy assessed using the bar test was measured in both adenosine A2A receptor knockout (A2AR KO) and wild-type (A2AR WT) mice submitted to acute administration of the dopamine D2 receptor antagonist haloperidol (0.5, 2, 4, 6 mg/kg i.p.), the dopamine D1 antagonist SCH 23390 (0.3-3 mg/kg, s.c.), the vesicular monoamine transporter blocker reserpine (3-5 mg/kg, s.c.) or the acetylcholine muscarinic receptor agonist pilocarpine (25-50 mg/kg, i.p.). Except for reserpine, catalepsy scores were significantly lower in A2AR KO mice than in A2AR WT mice following low doses of these cataleptogenic agents. These results suggest that adenosine A2A receptors influence not only dopamine D2 and D1 receptor-mediated neurotransmission but also acetylcholine muscarinic receptor-mediated neurotransmission.
El Yacoubi
M
M
UMR 6036 CNRS, IFRMP 23, UFR de Médecine and Pharmacie, Rouen, France.
Ledent
C
C
Parmentier
M
M
Costentin
J
J
Vaugeois
J M
JM
D000818:Animals; D001552:Benzazepines; D002375:Catalepsy / Q000139:chemically induced* / Q000235:genetics; D018492:Dopamine Antagonists; D006220:Haloperidol; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D018721:Muscarinic Agonists; D010862:Pilocarpine; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1 / Q000235:genetics / Q000502:physiology*; D012110:Reserpine; D013565:Sympatholytics
D001552:Benzazepines; D018492:Dopamine Antagonists; D018721:Muscarinic Agonists; D043705:Receptor, Adenosine A2A; D018047:Receptors, Purinergic P1; D013565:Sympatholytics; D010862:Pilocarpine; D012110:Reserpine; D006220:Haloperidol