United Kingdom Children's Cancer Study Group (UKCCSG) radiotherapy and brain tumour groups: medulloblastoma/PNET and craniospinal radiotherapy (CSRT): report of a workshop held in Leeds, 30 June 1999.
Primitive neuroectodermal tumours (PNET), of which cerebellar medulloblastoma is the most frequent, are embryonal central nervous system tumours arising mainly in children. They are characterized by their propensity for metastasis via the cerebrospinal fluid. They are radiosensitive and craniospinal radiotherapy (CSRT) is an important part of their management. This is a complex radiotherapy (RT) technique, the accuracy of which contributes to the survival and quality of survival of treated children. In the last 25 years, European and North American collaborative studies have investigated the role of adjuvant chemotherapy. The planning and delivery of CSRT have to be of the highest quality. It is important to incorporate all modern technical RT developments into CSRT. It is possible that optimizing fractionation may further improve outcome. The purpose of this workshop was to review the current status of CSRT planning and administration in the light of RT developments. Current results of the treatement of medulloblastoma and PNET were reviewed and UK involvement in possible future collaborative trials was discussed.
Taylor
R E
RE
Cookridge Hospital, Leeds, UK.
D001921:Brain; D002528:Cerebellar Neoplasms / Q000532:radiotherapy*; D002648:Child; D002986:Clinical Trials as Topic; D019583:Dose Fractionation, Radiation; D006801:Humans; D008527:Medulloblastoma / Q000532:radiotherapy*; D015337:Multicenter Studies as Topic; D018242:Neuroectodermal Tumors, Primitive / Q000532:radiotherapy*; D011379:Prognosis; D011785:Quality Assurance, Health Care; D011878:Radiotherapy / Q000379:methods*; D013116:Spinal Cord