title: Bifurcated drum occluder endograft for treatment of abdominal aortic aneurysm: an experimental study in dogs.
abstract: OBJECTIVE
  To evaluate a new, low profile, home-made, bifurcated drum occluder endograft (BDOEG), designed for percutaneous, transcatheter treatment of abdominal aortic aneurysm (AAA).
  
  
  METHODS
  AAA was created in 10 dogs with over-dilated Palmaz stents. To prevent back filling, the lumbar arteries, inferior mesenteric artery, and common internal iliac arteries were embolized. The BDOEG was constructed of a drum occluder device and two PTFE endografts. The drum device consisted of a modified Z stent with Dacron stretched across and held within the ends of the stent, each with two 8 x 6-mm slits through which PTFE endografts were delivered. The PTFE endografts were 8 mm in diameter and 9.5 cm in length. Preloaded, the BDOEG was delivered through a 10-F sheath from both femoral arteries in a three-step procedure. All 10 animals were treated with BDOEG. Aortography was performed immediately, 6 weeks, and 12 weeks after stent-graft placement. Five animals were killed at 6 weeks and five were killed at 3 months. Gross and histologic evaluation was performed.
  
  
  RESULTS
  The infrarenal aortic diameters and both external iliac arteries ranged from 8.0 mm to 10.3 mm (mean, 9.4 mm +/- 0.6) and from 5.2 mm to 6.8 mm (mean, 5.8 mm +/- 0.5), respectively. Creation of the AAA was successful in all 10 dogs. AAA diameters ranged from 13.7 mm to 15.9 mm (mean, 14.9 mm +/- 0.7). Complete exclusion of the AAA was achieved immediately after BDOEG placement and aneurysms remained excluded without perigraft leak to the time of killing in all 10 animals. There was a high incidence of aortoiliac limb occlusion. Occlusion of 12 aortoiliac limbs (60%) caused by intimal hyperplasia at the distal end of the endografts in iliac arteries developed in nine animals (90%). In six animals (60%), one limb occluded and, in three animals (30%), there was occlusion of both limbs.
  
  
  CONCLUSIONS
  This study suggests a new approach for treatment of AAA. BDOEG use reduces sheath size for endograft delivery and may eliminate the need for a surgical cut down on femoral arteries. Tapering of the iliac ends of endografts to the size of the artery will be needed to prevent distal intimal hyperplasia.
authors: Dotter Interventional Institute, Oregon Health Sciences University, Portland 97201, USA. pavcnikd@ohsu.edu
authors: D
authors: D
authors: Pavcnik
authors: B T
authors: BT
authors: Uchida
authors: H
authors: H
authors: Timmermans
authors: B
authors: B
authors: Petersen
authors: M
authors: M
authors: Loriaux
authors: K
authors: K
authors: Yamakado
authors: J
authors: J
authors: Voda
authors: Q
authors: Q
authors: Yin
authors: F S
authors: FS
authors: Keller
authors: J
authors: J
authors: Rösch
mesh_terms: D000818:Animals; D017544:Aortic Aneurysm, Abdominal / Q000628:therapy*; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation; D004285:Dogs; D004867:Equipment Design; D020007:Implants, Experimental; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D015607:Stents
chemical_list: D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene