title: Comparative pulmonary toxicity of 6 abrasive blasting agents.
abstract: Inhalation of silica dust is associated with pulmonary fibrosis. Therefore, substitute abrasive materials have been suggested for use in abrasive blasting operations. To date, toxicological evaluation of most substitute abrasives has been incomplete. Therefore, the objective of this study was to compare the pulmonary toxicity of a set of substitute abrasives (garnet, staurolite, coal slag, specular hematite, and treated sand) to that of blasting sand. Rats were exposed to blasting sand or an abrasive substitute by intratracheal instillation and pulmonary responses to exposure were monitored 4 weeks postexposure. Pulmonary damage was monitored as lactate dehydrogenase (LDH) in the acellular lavage fluid. Pulmonary inflammation was evaluated from the yield of polymorphonuclear leukocytes (PMN) obtained by bronchoalveolar lavage. The activity of alveolar macrophages was determined by measuring zymosan-stimulated chemiluminescence. Blasting sand caused lung damage and showed histologic evidence for inflammation and fibrosis. Garnet, staurolite, and treated sand exhibited toxicity and inflammation that were similar to blasting sand, while coal slag caused greater pulmonary damage and inflammation than blasting sand. In contrast, specular hematite did not significantly elevate LDH or PMN levels and did not stimulate macrophage activity 4 weeks postexposure.
authors: Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, 1095 Willowdale Road, Morgantown, West Virginia 26505, USA. afh0@cdc.gov
authors: A F
authors: AF
authors: Hubbs
authors: N S
authors: NS
authors: Minhas
authors: W
authors: W
authors: Jones
authors: M
authors: M
authors: Greskevitch
authors: L A
authors: LA
authors: Battelli
authors: D W
authors: DW
authors: Porter
authors: W T
authors: WT
authors: Goldsmith
authors: D
authors: D
authors: Frazer
authors: D P
authors: DP
authors: Landsittel
authors: J Y
authors: JY
authors: Ma
authors: M
authors: M
authors: Barger
authors: K
authors: K
authors: Hill
authors: D
authors: D
authors: Schwegler-Berry
authors: V A
authors: VA
authors: Robinson
authors: V
authors: V
authors: Castranova
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry* / Q000166:cytology*; D003031:Coal / Q000032:analysis / Q000633:toxicity*; D005290:Ferric Compounds / Q000032:analysis / Q000633:toxicity*; D007770:L-Lactate Dehydrogenase / Q000737:chemistry*; D008168:Lung / Q000166:cytology* / Q000201:enzymology*; D016676:Macrophages, Alveolar / Q000201:enzymology / Q000473:pathology; D008297:Male; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000032:analysis / Q000633:toxicity*; D009504:Neutrophils / Q000201:enzymology / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000201:enzymology* / Q000473:pathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012822:Silicon Dioxide / Q000032:analysis / Q000633:toxicity*
chemical_list: D003031:Coal; D005290:Ferric Compounds; D008903:Minerals; C078335:staurolite; C000499:ferric oxide; D012822:Silicon Dioxide; D007770:L-Lactate Dehydrogenase