title: Electrospray ionization gas-phase electrophoresis under ambient conditions and it's potential or high-speed separations.
abstract: A moderately high resolution nanoelectrospray ionization gas-phase electrophoresis instrument was constructed and evaluated for simple high-speed separations of several groups of compounds. The insertion of a plate containing a 1.6 cm diameter exit orifice, 2.5 cm from the location of electrospray, allowed ions to be created and desolvated under ambient conditions with minimal solvent contamination to the drift tube. Ion separation selectivity is discussed and shown to be slightly altered by changing the drift gas flow rate. Issues of using gas-phase electrophoresis as a high-speed separation technique are discussed. Gas-phase electrophoresis-spectra of selected benzodiazepines, triazine herbicides, and simple combinatorial chemistry libraries are demonstrated.
authors: Brigham Young University, Department of Chemistry and Biochemistry, Provo, Utah 84602-5700, USA.
authors: D C
authors: DC
authors: Collins
authors: M L
authors: ML
authors: Lee
mesh_terms: D000525:Alprazolam / Q000032:analysis; D014151:Anti-Anxiety Agents / Q000032:analysis*; D020650:Combinatorial Chemistry Techniques; D003975:Diazepam / Q000032:analysis; D004586:Electrophoresis / Q000295:instrumentation / Q000379:methods*; D004867:Equipment Design; D006540:Herbicides / Q000032:analysis*; D009567:Nitrazepam / Q000032:analysis; D010076:Oxazepam / Q000032:analysis; D011222:Prazepam / Q000032:analysis; D013997:Time Factors; D014227:Triazines / Q000032:analysis
chemical_list: D014151:Anti-Anxiety Agents; D006540:Herbicides; D014227:Triazines; D010076:Oxazepam; D009567:Nitrazepam; D011222:Prazepam; D003975:Diazepam; D000525:Alprazolam