[Lesion caused by ischemia-reperfusion in lung transplantation].
OBJECTIVE
To assess the existence or not of a relation between the characteristics of lung donor and/or recipient and the development of ischemia-reperfusion injury (IRI). We also review the latest experimental findings on the biophysical conditions pf graft preservation.


METHODS
A retrospective study of 74 lung transplants performed in our hospital from 1993 to 1998. Donor and recipient screening and anesthetic and surgical techniques were performed following established protocols. Various degrees of IRI were determined according to hemodynamic and gasometric criteria. We analyzed the statistical relation between donor and recipient variables and IRI. Statistical significance was set at p < 0.05.


RESULTS
The incidence of IRI was 70.2% (52 cases), with 12 cases categorized as mild, 22 as moderate and 18 as severe. IRI was significantly related only to the start of extracorporeal circulation.


CONCLUSIONS
The development of IRI in lung transplantation is linked to such donor and/or recipient characteristics as the biophysical conditions of graft preservation. At present, greater prevention of this type of early dysfunction of the lung graft requires not only use of adequate screening criteria for donors and receivers but also adequate measures for graft preservation with the use of drugs and handling that have been shown to be effective.
Soria
A
A
Servicio de Anestesiología-Reanimación y Terapéutica del Dolor, Hospital Universitario La Fe, Valencia.
Vicente
R
R
Ramos
F
F
López
L M
LM
Francia
C
C
Montero
R
R
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D004487:Edema / Q000209:etiology / Q000517:prevention & control; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D005260:Female; D006085:Graft Survival; D006801:Humans; D015994:Incidence; D007511:Ischemia / Q000453:epidemiology* / Q000209:etiology; D008168:Lung / Q000098:blood supply*; D016040:Lung Transplantation / Q000379:methods / Q000706:statistics & numerical data*; D008297:Male; D008875:Middle Aged; D020556:Neutrophil Infiltration / Q000187:drug effects; D009926:Organ Preservation; D010477:Perfusion; D011183:Postoperative Complications / Q000453:epidemiology* / Q000209:etiology; D011651:Pulmonary Artery; D017382:Reactive Oxygen Species; D015427:Reperfusion Injury / Q000453:epidemiology* / Q000209:etiology; D012189:Retrospective Studies; D014019:Tissue Donors; D020858:Tissue and Organ Harvesting / Q000379:methods
D017382:Reactive Oxygen Species