title: Hyperosmolar diabetic non-ketotic coma, hyperkalaemia and an unusual near death experience.
abstract: Generally, cardiac arrest due to pulseless electrical activity has a poor outcome, except when reversible factors such as acute hyperkalaemia are identified and managed early. Hyperosmolar diabetic non-ketotic coma may lead to acute hyperkalaemia. Hyperosmolar diabetic non-ketotic coma is a metabolic emergency usually seen in elderly non-insulin dependent diabetics, characterized by severe hyperglycaemia, volume depletion, altered consciousness, confusion and less frequently neurological deficit. Cerebrovascular accident or transient ischaemic attack may be mistakenly diagnosed, particularly if the patient has no history of diabetes mellitus. Delays in diagnosis and management of glycaemic emergencies presenting as a constellation of neurological abnormalities can be avoided by routine early measurement of blood glucose. Hyperosmolar diabetic non-ketotic coma should be considered in any patient with altered consciousness or neurologic deficit in conjunction with hyperglycaemia. As hyperosmolar diabetic non-ketotic coma results in severe fluid depletion, electrolyte disturbance, profound hyperglycaemia and an altered mental state, the guiding principles of therapy include aggressive rehydration, insulin therapy, correction of electrolyte abnormalities and treatment of any underlying illnesses. Treatment of acute hyperkalaemia includes calcium ions, insulin with dextrose, salbutamol and haemodialysis.
authors: Department of Emergency Medicine, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
authors: J Y
authors: JY
authors: Ting
mesh_terms: D002303:Cardiac Output, Low / Q000175:diagnosis / Q000628:therapy; D016887:Cardiopulmonary Resuscitation; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis / Q000628:therapy; D004562:Electrocardiography; D005500:Follow-Up Studies; D006323:Heart Arrest / Q000175:diagnosis* / Q000628:therapy; D006801:Humans; D006944:Hyperglycemic Hyperosmolar Nonketotic Coma / Q000175:diagnosis* / Q000628:therapy; D006947:Hyperkalemia / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged