title: Melatonin replacement therapy in a child with a pineal tumor.
abstract: The case report of a child with the diagnosis of a pineal tumor and severe, chronic sleep disorder is reported. Due to treatment of her lesion, the nighttime melatonin secretion was markedly suppressed. For 4(1/2) years, she has been receiving oral melatonin, which has greatly improved her sleep, without any adverse effects. Sleep difficulties should be considered in the management of pineal lesions. Melatonin replacement therapy is beneficial for those patients who have deficient melatonin synthesis.
authors: Division of Developmental Paediatrics, University of British Columbia, Vancouver. jjan@cw.bc.ca
authors: J E
authors: JE
authors: Jan
authors: J
authors: J
authors: Tai
authors: G
authors: G
authors: Hahn
authors: R R
authors: RR
authors: Rothstein
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000150:complications* / Q000601:surgery; D002648:Child; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D005260:Female; D020249:Hormone Replacement Therapy; D006801:Humans; D008550:Melatonin / Q000008:administration & dosage / Q000627:therapeutic use*; D010870:Pineal Gland; D010871:Pinealoma / Q000150:complications* / Q000601:surgery; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy* / Q000209:etiology; D016896:Treatment Outcome
chemical_list: D008550:Melatonin