title: Landmark-based morphometrics of the normal adult brain using MRI.
abstract: We describe the application of statistical shape analysis to homologous landmarks on the cortical surface of the adult human brain. Statistical shape analysis has a sound theoretical basis. Landmarks are identified on the surface of a 3-D reconstruction of the segmented cortical surface from magnetic resonance image (MRI) data. Using publicly available software (morphologika) the location and size dependence of the landmarks are removed and the differences in landmark distribution across subjects are analysed using principal component analysis. These differences, representing shape differences between subjects, can be visually assessed using wireframe models and transformation grids. The MRI data of 58 adult brains (27 female and 15 left handed) were examined. Shape differences in the whole brain are described which concern the relative orientation of frontal lobe sulci. Analysis of all 116 hemispheres revealed a statistically significant difference (P < 0.001) between left and right hemispheres. This finding was significant for right- but not left-handed subjects alone. No other significant age, gender, handedness, or brain-size correlations with shape differences were found.
authors: Epilepsy Research Group, National Society for Epilepsy MRI unit, Institute of Neurology, Queen Square, London.
authors: S L
authors: SL
authors: Free
authors: P
authors: P
authors: O'Higgins
authors: D D
authors: DD
authors: Maudgil
authors: I L
authors: IL
authors: Dryden
authors: L
authors: L
authors: Lemieux
authors: D R
authors: DR
authors: Fish
authors: S D
authors: SD
authors: Shorvon
mesh_terms: D000293:Adolescent; D000328:Adult; D001931:Brain Mapping; D002508:Cephalometry / Q000706:statistics & numerical data; D002540:Cerebral Cortex / Q000033:anatomy & histology*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000033:anatomy & histology; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008432:Mathematical Computing; D008875:Middle Aged; D012016:Reference Values