Involvement of the sigma receptor in passive-avoidance learning in the day-old chick during the second wave of neuronal activity.
The specific sigma-receptor agonist (+)-SKF 10047 and antagonist BD 1047 were used to investigate whether this receptor was involved in passive-avoidance training in the day-old chick. We found 300 microM (+)-SKF 10047 to be amnesic when injected into the lobus parolfactorius 5 h after training (p < .01). Higher or lower concentrations of (+)-SKF 10047 did not disrupt memory formation. The amnesia produced by the efficacious dose of (+)-SKF 10047 was reversed by the specific antagonist, BD 1047. It is suggested that the sigma-receptor may exert its effect on passive-avoidance memory consolidation during the later stages of long-term memory formation by modulation of memory-related neurotransmission.
Freeman
F M
FM
Division of Biochemistry & Molecular Biology, John Curtin School of Medical Research, Canberra, ACT, 0200, Australia.
Young
I G
IG
D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D000831:Animals, Newborn; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000037:antagonists & inhibitors; D001362:Avoidance Learning / Q000187:drug effects*; D002645:Chickens; D005029:Ethylenediamines / Q000008:administration & dosage / Q000494:pharmacology; D009830:Olfactory Bulb / Q000187:drug effects; D010620:Phenazocine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D017480:Receptors, sigma / Q000037:antagonists & inhibitors / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects
D014150:Antipsychotic Agents; D005029:Ethylenediamines; D017480:Receptors, sigma; C097963:N-(2-(3,4-Dichlorphenyl)ethyl)-N,N',N'-trimethyl-1,2-ethandiamin; C012134:SK&F 10047; D010620:Phenazocine