Stimulatory and protective effects of alkylating agents applied in ultra-low concentrations.
Alkylating drugs belonging to the nitrogen mustard family are known as cytostatic and immunosuppressive agents. Ultra-low doses of these drugs may demonstrate pharmacological effects unlike this category of drugs. In the case of a gradual dose decrease, the number of targets for alkylation is also reduced and the drug switches from cytostatic to cell growth modifier. We postulate that application of ultra-low doses of alkylating drugs may result in a beneficial effect in the therapy of diseases associated with chronic inflammation of the mucosa, especially with the signs of epithelial atrophy.
Pukhalsky
A L
AL
Research Centre for Medical Genetics, 1 Moskvorechie Street, Moscow 115478, Russia. vikgor@arstel.ru
Shmarina
G V
GV
D000477:Alkylating Agents / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use*; D004847:Epithelial Cells / Q000187:drug effects / Q000502:physiology; D053222:Fas Ligand Protein; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008214:Lymphocytes / Q000187:drug effects*; D008562:Membrane Glycoproteins / Q000378:metabolism; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D019014:fas Receptor / Q000378:metabolism
D000477:Alkylating Agents; C505661:FASLG protein, human; D053222:Fas Ligand Protein; D008562:Membrane Glycoproteins; D015375:Receptors, Interleukin-2; D019014:fas Receptor