Inheritance of Hippel-Lindau disease: a rare case of maxillary bone metastasis.
A rare case of familial Hippel-Lindau disease, which is an autosomal dominant disorder with inherited susceptibility to various forms of cancer, is reported in a 46-year-old father and his sons. The father complained of a malignant hypernephroma, which metastasized in the upper jaw 6 months later. As in this patient, renal cell carcinomas are fatal and are exhibited at an early age. Consequentially, patients with familial von Hippel-Lindau disease exhibiting cases of renal cell carcinoma should be examined very carefully in the head and neck region to detect and treat metastases as early as possible.
Hönig
J F
JF
Department of Craniofacial and Plastic Surgery, University Hospital and Medical School of Goettingen, Robert-Koch-Strasse 40, D-37075 Goettingen, Germany.
D000539:Alveolar Process / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000473:pathology / Q000556:secondary*; D017809:Fatal Outcome; D018325:Hemangioblastoma / Q000473:pathology; D006801:Humans; D007680:Kidney Neoplasms / Q000473:pathology; D008297:Male; D008441:Maxillary Neoplasms / Q000556:secondary*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D006623:von Hippel-Lindau Disease / Q000235:genetics*