title: Peripheral administration of urocortin suppresses operant responding for food reward.
abstract: The effects of peripheral systemic administration of urocortin on operant responding to obtain food were investigated using three separate concentrations. The drug was administered intraparitoneally at a concentration of 10 microg/ml/Kg, 5 microg/ml/Kg, and 0 microg/ml/Kg suspended in saline at a volume of 1 ml/Kg to Sprague-Dawley rats fifteen minutes prior to being exposed to an operant bar press task. Eleven subjects were used, each receiving a single injection of each concentration on separate days with the order of treatment counterbalanced. The results indicated that the administration of urocortin in a dose dependent manner reduced responding of food deprived subjects for a food reward in a thirty minute session. These data indicated that the peripheral administration of urocortin reduced the motivation of food deprived subjects to respond.
authors: Section on Behavioral Neuropharmacology, NIMH, Bethesda, MD 20892-1375, USA. kinneyj@intra.nimh.nih.gov
authors: J W
authors: JW
authors: Kinney
authors: B
authors: B
authors: Scruggs
authors: D D
authors: DD
authors: Avery
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D005502:Food; D007274:Injections, Intraperitoneal; D008297:Male; D009042:Motivation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D054832:Urocortins
chemical_list: D054832:Urocortins; D003346:Corticotropin-Releasing Hormone