title: Adrenocortical carcinoma with cerebral metastasis in a child: case report and review of the literature.
abstract: OBJECTIVE
  Adrenocortical carcinoma (ACC) is rare in the pediatric population, and brain metastasis seldom occurs.
  
  
  METHODS
  The authors report a case of metastatic ACC to the brain in a 9-year-old patient who had an adrenal cortex neoplasm removed at 4 years of age, and was free of symptoms for 5 years. Two weeks before admission she complained of blurred vision in both eyes.
  
  
  METHODS
  Examination revealed bilateral papilledema, and a Magnetic Resonance Imaging (MRI) of the brain revealed a mass in the left lateral ventricle with extensive vasogenic edema and hydrocephalus. The tumor was removed, and histopathologic examination demonstrated metastatic ACC.
  
  
  CONCLUSIONS
  Although ACC is a rare neoplasm it must be considered in the differential diagnosis of cerebral lesions in patients with a history of this tumor. Periodic long-term brain imaging is suggested as part of the follow up in patients with adrenocortical neoplasms.
authors: Department of Pathology, University of Miami, Jackson Memorial Hospital, East Tower Room # 2142, 1611 NW 12th Ave., Miami, FL 33136, USA. rromague@med.miami.edu
authors: R L
authors: RL
authors: Romaguera
authors: A
authors: A
authors: Minagar
authors: J H
authors: JH
authors: Bruce
authors: J R
authors: JR
authors: Jagid
authors: S
authors: S
authors: Falcone
authors: R G
authors: RG
authors: Curless
authors: J
authors: J
authors: Ragheb
authors: G
authors: G
authors: Morrison
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery*; D018268:Adrenocortical Carcinoma / Q000175:diagnosis* / Q000556:secondary / Q000601:surgery*; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000556:secondary / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D003399:Craniotomy / Q000379:methods*; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D008279:Magnetic Resonance Imaging; D012008:Recurrence; D012086:Reoperation; D016896:Treatment Outcome