title: VDAC2 (porin-2) expression pattern and localization in the bovine testis.
abstract: In this study, sequencing of voltage-dependent anion channel 2 (VDAC2, porin-2) cDNA from bovine testis is reported. High identity to the murine, rabbit, and human subtypes at both the nucleotide and amino acid levels is demonstrated. mRNA analysis revealed expression of VDAC2 in bovine testis, whereas high levels of VDAC2 proteins were found in late spermatocytes, spermatids, and spermatozoa. In contrast, VDAC1 (porin-1) is exclusively localized in Sertoli cells. The possible role of testicular VDAC2 in providing energy metabolites and in germ cell apoptosis is discussed.
authors: Department of Dermatology and Andrology, Justus Liebig University, Gaffkystr. 14, D-35392, Giessen, Germany. klaus-dieter.hinsch@derma.med.uni-giessen.de
authors: K D
authors: KD
authors: Hinsch
authors: Asmarinah
authors: E
authors: E
authors: Hinsch
authors: L
authors: L
authors: Konrad
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D015870:Gene Expression; D007150:Immunohistochemistry; D008297:Male; D008969:Molecular Sequence Data; D018272:Porins / Q000032:analysis / Q000737:chemistry / Q000235:genetics*; D016415:Sequence Alignment; D013087:Spermatids / Q000378:metabolism; D013737:Testis / Q000737:chemistry / Q000378:metabolism*; D050995:Voltage-Dependent Anion Channel 1; D050996:Voltage-Dependent Anion Channel 2; D050994:Voltage-Dependent Anion Channels
chemical_list: D018076:DNA, Complementary; D018272:Porins; D050996:Voltage-Dependent Anion Channel 2; D050994:Voltage-Dependent Anion Channels; D050995:Voltage-Dependent Anion Channel 1