Synthesis of the beta-D-glucuronides of 2,3-, 3,4-, and 2,6-dichlorophenol.
The beta-D-glucuronides of 2,3-, 3,4-, and 2,6-dichlorophenol (1-3) were prepared by a modified Koenigs-Knorr synthesis. As the alkaline hydrolysis of perpivaloylated methyl (2,3-dichlorophenyl)-glucuronate 1a led to a dehydrated glucuronide, the preparation of peracetylated methyl dichlorophenylglucuronates with subsequent cleavage of the ester bindings under mild conditions was preferred.
Goenechea
S
S
Institut für Rechtsmedizin, Universität Bonn, Stiftsplatz 12, D-53111 Bonn, Germany.
Rücker
G
G
Hubert
M A
MA
D000440:Butanols; D002733:Chlorophenols / Q000737:chemistry*; D020719:Glucuronides / Q000138:chemical synthesis*
D000440:Butanols; D002733:Chlorophenols; D020719:Glucuronides; C091932:2,3-dichlorophenol; C032729:2,6-dichlorophenol; C004762:2,4-dichlorophenol