Immunology 102 at poxvirus U: avoiding apoptosis.
Poxviruses are large complex viruses that replicate in the cytoplasm of cells without integrating their DNA into the host genome or undergoing a latent intracellular stage. In addition to viral enzymes for DNA and RNA synthesis, poxviruses encode many proteins that modulate host responses. These include inhibitors of apoptosis induced by ligand binding to cell surface receptors, peroxides, ultraviolet light, DNA damaging agents and other cell signaling pathways.
Shisler
J L
JL
Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 4 Center Drive, Bethesda, MD 20892-0445, MSC 0445, USA.
Moss
B
B
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D006801:Humans; D011212:Poxviridae / Q000276:immunology* / Q000472:pathogenicity / Q000502:physiology; D011213:Poxviridae Infections / Q000276:immunology* / Q000473:pathology* / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology
D014764:Viral Proteins