Association study of CAG repeats in the KCNN3 gene in Japanese patients with schizophrenia, schizoaffective disorder and bipolar disorder.
To investigate a possible involvement of expanded triplet repeats of genome in the genomes of patients with endogenous psychoses, we examined a CAG repeat polymorphism in the coding region of the KCNN3 gene in schizophrenia, schizoaffective disorder, bipolar disorder and controls of the Japanese population. There were no significant differences in the CAG repeat number of longer or shorter alleles among the four diagnostic groups or among the schizophrenia hebephrenic and paranoid subtypes.
Ujike
H
H
Department of Neuropsychiatry, Okayama University Medical School, 2-5-1 Shikata-cho, 700-8558, Okayama, Japan. hujike@cc.okayama-u.ac.jp
Yamamoto
A
A
Tanaka
Y
Y
Takehisa
Y
Y
Takaki
M
M
Taked
T
T
Kodama
M
M
Kuroda
S
S
D000225:Adenine / Q000378:metabolism; D000328:Adult; D000483:Alleles; D044466:Asian People / Q000235:genetics*; D001714:Bipolar Disorder / Q000208:ethnology / Q000235:genetics*; D016022:Case-Control Studies; D003596:Cytosine / Q000378:metabolism; D005260:Female; D006147:Guanine / Q000378:metabolism; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D015221:Potassium Channels / Q000235:genetics*; D024681:Potassium Channels, Calcium-Activated; D011618:Psychotic Disorders / Q000208:ethnology / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000235:genetics*; D051640:Small-Conductance Calcium-Activated Potassium Channels; D013941:Thymine / Q000378:metabolism; D018911:Trinucleotide Repeats / Q000235:genetics*
C406328:KCNN3 protein, human; D015221:Potassium Channels; D024681:Potassium Channels, Calcium-Activated; D051640:Small-Conductance Calcium-Activated Potassium Channels; D006147:Guanine; D003596:Cytosine; D000225:Adenine; D013941:Thymine