title: Associations between dietary intakes and blood cholesterol concentrations at 31 months.
abstract: OBJECTIVE
  The initial stages of atherosclerosis have been shown to occur in children as young as 3. Elevated total and LDL cholesterol concentrations and low HDL concentrations are a well-established risk factor for atherosclerosis. The objective of this study was to investigate the dietary determinants of blood lipid concentrations at 31 months of age.
  
  
  METHODS
  A randomly selected group of children (214 boys, 175 girls) in south-west England forming part of the Avon Longitudinal Study of Pregnancy and Childhood (ALSPAC) cohort.
  
  
  METHODS
  Three-day dietary records were obtained at 18 months. At 31 months a non-fasting blood sample was taken and analysed for total and HDL cholesterol and triglyceride, and measures of height and weight were taken.
  
  
  RESULTS
  Among boys, total cholesterol concentrations were positively associated with the intake of total fat (r=0.209, P=0.002) and saturated fatty acids (r=0.211, P=0.002). Among girls, HDLC was positively associated with energy intake (r=0.204, P=0.018), and negatively associated with intakes of polyunsaturated fat, saturated fat and sugar in multivariate analysis. There were no associations between the intakes of non-starch polysaccharides (fibre) or dietary cholesterol and total or HDL cholesterol concentrations in either sex. Among boys, higher intakes of breakfast cereals were associated with lower total cholesterol (r=-0.187, P=0.008). Among girls, higher intakes of biscuits and meat and meat products were associated with higher HDLC concentrations.
  
  
  CONCLUSIONS
  These data suggest that the dietary determinants of blood lipid concentrations differ between boys and girls. Reducing saturated fat intake in boys would be likely to lead to an improvement in blood lipid profiles. In this study there is no evidence to suggest that an increase in the intake of polyunsaturated fat by pre-school children would result in improved blood lipid profiles.
authors: Division of Child Health, University of Bristol, UK.
authors: I S
authors: IS
authors: Cowin
authors: P M
authors: PM
authors: Emmett
mesh_terms: D000886:Anthropometry; D001161:Arteriosclerosis / Q000517:prevention & control*; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D004032:Diet; D015930:Diet Records; D004041:Dietary Fats / Q000008:administration & dosage*; D002149:Energy Intake / Q000502:physiology; D005227:Fatty Acids / Q000008:administration & dosage / Q000097:blood; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D005227:Fatty Acids; D014280:Triglycerides; D002784:Cholesterol