FR198248, a new anti-influenza agent isolated from Apsergillus terreus No 13830. I. Taxomony, fermentation, isolation, physico-chemical properties and biological activities.
A novel anti-influenza agent, FR198248, was isolated from the cultured broth of a fungal strain No.13830. The strain was identified as Aspergillus terreus from morphological characteristics. FR198248, a new type of hydroxyl benzaldehyde compound, showed antiinfluenza virus activity in Madin-Darby canine kidney (MDCK) cells in vitro. The mode of action of FR198248 against influenza virus A could be ascribed to an inhibitory effect on the stage of virus adsorption. Furthermore, FR198248 possessed potent in vivo anti-influenza activity in a murine model of respiratory tract infection.
Nishihara
Y
Y
Fermentation Development Laboratories, Fujisawa Pharmaceutical Co., Ltd., Aichi, Japan. Yutaka_Nishihara@po.fujisawa.co.jp
Tsujii
E
E
Yamagishi
Y
Y
Sakamoto
K
K
Tsurumi
Y
Y
Furukawa
S
S
Ohtsu
R
R
Kino
T
T
Hino
M
M
Yamashita
M
M
Hashimoto
S
S
D000818:Animals; D000998:Antiviral Agents; D001230:Aspergillus / Q000378:metabolism*; D001572:Benzofurans; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D005260:Female; D009980:Influenza A virus / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008826:Microbial Sensitivity Tests; D013050:Spectrometry, Fluorescence
D000998:Antiviral Agents; D001572:Benzofurans; C424923:FR 198248