P-glycoprotein expression in squamous cell carcinoma of the oral and maxillofacial region.
OBJECTIVE
To investigate the mechanism of drug resistance in oral and maxillofacial carcinoma to chemotherapy.


METHODS
Forty cases of squamous carcinoma in the oral and maxillofacial region were examined for the multidrug resistance gene product P-glycoprotein using a monoclonal antibody, MRK16.


RESULTS
P-glycoprotein was detected in 62.5% of all samples. P-glycoprotein expression was related to the chemotherapy and the differentiation of carcinoma. P-glycoprotein expression was higher in the post-chemotherapy group than in the non-chemotherapy group (P < 0.05). Well-differentiated tumors expressed P-glycoprotein more frequently (P < 0.05). P-glycoprotein expression was compared with clinical response to chemotherapy. The accuracy rate of prediction was 75%.


CONCLUSIONS
P-glycoprotein plays an important role in mechanism of drug resistance of squamous cell carcinoma in the oral and maxillofacial region.
Xie
Z J
ZJ
Department of Stomatology, First Affiliated Hospital, Zhejiang Medical University, No. 261 Qingchun Road, Hangzhou, 310003, P. R. China.
Yang
X F
XF
Gu
Z Y
ZY
Wu
Q L
QL
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000032:analysis / Q000235:genetics*; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D002454:Cell Differentiation; D019008:Drug Resistance, Neoplasm / Q000235:genetics; D005153:Facial Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D005260:Female; D005544:Forecasting; D015972:Gene Expression Regulation, Neoplastic; D019450:Genes, MDR / Q000235:genetics; D006801:Humans; D007573:Jaw Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D009367:Neoplasm Staging; D012074:Remission Induction; D016896:Treatment Outcome
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000911:Antibodies, Monoclonal