title: Method for measuring long-term function of muscle-powered implants via radiotelemetry.
abstract: Long-term remote monitoring of muscle-powered implants has been made possible with development of an adjustable workload that can be remotely monitored to assess device function. This technique obviates the need for percutaneous access lines and allows test animals to remain untethered, eliminating deleterious effects caused by infection, sedation, or animal stress. Hardware components include a latex bladder fixed within a hermetically sealed canister, multichannel implantable telemetry unit, and subcutaneous access port (for pressure charge adjustment). To validate this method, in vitro tests were performed by using a third-generation muscle energy converter designed to function as an implantable hydraulic pump. Two channels of telemetered pressure data were collected and used to calculate six indexes of device function. Calculated parameters were then compared with measured values to determine accuracy. Correlation between measured and calculated parameters was high in all instances, with most estimates yielding errors of <3%. These results demonstrate the utility of this approach and support its use as a means to monitor muscle-powered devices during long-term animal trials.
authors: Cardiothoracic Surgery Research, Allegheny-Singer Research Institute, and Department of Surgery, Allegheny General Hospital, West Penn Allegheny Health System, Pittsburgh, Pennsylvania 15212, USA. trumble@wpahs.org
authors: D R
authors: DR
authors: Trumble
authors: J A
authors: JA
authors: Magovern
mesh_terms: D000818:Animals; D004285:Dogs; D004867:Equipment Design; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000502:physiology*; D019736:Prostheses and Implants; D011845:Radio; D012044:Regression Analysis; D013686:Telemetry / Q000295:instrumentation* / Q000379:methods*