Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies.
Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte antigen loci was used to reconstitute the immune system in 2 brothers with X-linked lymphoproliferative syndrome and 1 boy with X-linked hyperimmunoglobulin-M syndrome. Pretransplant cytoreduction and posttransplant graft-versus-host prophylaxis were given. Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years after transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplantation in primary immunodeficiencies.
Ziegner
U H
UH
Division of Immunology/Allergy/Rheumatology, Mattel Children's Hospital at UCLA, Los Angeles, California 90095-1752, USA.
Ochs
H D
HD
Schanen
C
C
Feig
S A
SA
Seyama
K
K
Futatani
T
T
Gross
T
T
Wakim
M
M
Roberts
R L
RL
Rawlings
D J
DJ
Dovat
S
S
Fraser
J K
JK
Stiehm
E R
ER
D023201:CD40 Ligand / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis / Q000379:methods; D005312:Fetal Blood / Q000166:cytology*; D006086:Graft vs Host Disease / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology
D023201:CD40 Ligand