title: Prenatal diagnosis of congenital nephrosis by in utero kidney biopsy.
abstract: The diagnosis of congenital nephrosis is difficult during the antepartum period. The combination of an elevated amniotic fluid alpha-fetoprotein, a negative acetylcholinesterase, and a negative ultrasound examination is highly indicative of congenital nephrosis; however, these findings can also be associated with a normal gestation. This is the first report of pathologic confirmation of congenital nephrosis from an in utero fetal kidney biopsy.
authors: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107-5083, USA.
authors: R J
authors: RJ
authors: Wapner
authors: T M
authors: TM
authors: Jenkins
authors: N
authors: N
authors: Silverman
authors: M
authors: M
authors: Kaufmann
authors: C
authors: C
authors: Hannau
authors: P
authors: P
authors: McCue
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis; D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry; D001706:Biopsy; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007668:Kidney / Q000473:pathology*; D009401:Nephrosis / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D016216:Ultrasonography, Prenatal; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins; D000110:Acetylcholinesterase