title: Toxicity testing of Senna occidentalis seed in rabbits.
abstract: The effect was investigated of administering ground Senna occidentalis seeds to rabbits in different concentrations (1%, 2%, 3% and 4%) in the ration. The experiment lasted 30 days and the toxic effects of the plant were evaluated on the basis of weight gain, histopathological, biochemical and morphometric parameters, as well as histochemistry and electron microscopy. Animals that received the ration containing 4% ground S. occidentalis seeds gained less weight (p < 0.05) and died in the third week. Histopathology revealed that the heart and liver were the main organs affected, with myocardial necrosis and centrolobular degeneration. There was a reduction in cytochrome oxidase activity in the glycogenolytic fibres, together with muscle atrophy, confirmed by the morphometric studies. Electron microscopy of the liver cells revealed dilated mitochondria, with destruction of the internal cristae.
authors: Research Center for Veterinary Toxicology (CEPTOX), Department of Pathology, Faculty of Veterinary Medicine, University of São Paulo, São Paulo, Brazil.
authors: A C
authors: AC
authors: Tasaka
authors: R
authors: R
authors: Weg
authors: E E
authors: EE
authors: Calore
authors: I L
authors: IL
authors: Sinhorini
authors: M L
authors: ML
authors: Dagli
authors: M
authors: M
authors: Haraguchi
authors: S L
authors: SL
authors: Górniak
mesh_terms: D000821:Animal Feed; D000818:Animals; D002366:Cassia / Q000633:toxicity*; D003576:Electron Transport Complex IV / Q000378:metabolism; D005506:Food Contamination; D006321:Heart; D006651:Histocytochemistry; D008099:Liver / Q000201:enzymology / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D018485:Muscle Fibers, Skeletal / Q000201:enzymology; D009133:Muscular Atrophy / Q000662:veterinary; D009206:Myocardium / Q000473:pathology*; D010946:Plants, Medicinal; D011817:Rabbits; D012639:Seeds / Q000633:toxicity*; D018675:Toxicity Tests / Q000662:veterinary; D015430:Weight Gain
chemical_list: D003576:Electron Transport Complex IV