THUMP--a predicted RNA-binding domain shared by 4-thiouridine, pseudouridine synthases and RNA methylases.
Sequence profile searches were used to identify an ancient domain in ThiI-like thiouridine synthases, conserved RNA methylases, archaeal pseudouridine synthases and several uncharacterized proteins. We predict that this domain is an RNA-binding domain that adopts an alpha/beta fold similar to that found in the C-terminal domain of translation initiation factor 3 and ribosomal protein S8.
Aravind
L
L
National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. aravind@ncbi.nlm.nih.gov
Koonin
E V
EV
D000595:Amino Acid Sequence; D001665:Binding Sites; D006836:Hydro-Lyases / Q000378:metabolism*; D008969:Molecular Sequence Data; D012313:RNA / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D013891:Thiouridine / Q000378:metabolism*; D012359:tRNA Methyltransferases / Q000378:metabolism*
D016601:RNA-Binding Proteins; D013891:Thiouridine; D012313:RNA; D012359:tRNA Methyltransferases; D006836:Hydro-Lyases; C022479:pseudouridylate synthetase