Interleukin-6 (IL-6) producing phaeochromocytoma: direct IL-6 suppression by non-steroidal anti-inflammatory drugs.
A 35-year-old Japanese woman presented with a phaeochromocytoma and demonstrated marked inflammatory reactions and pyrexia as a result of excessive production of interleukin-6 (IL-6) by the tumour. Serum IL-6 level was 262 ng/l (normal; < 4.0 ng/l). Fever and inflammatory markers were largely overcome by the administration of the nonsteroidal anti-inflammatory drug, naproxen, and all symptoms disappeared soon after the tumour was excised. Immunohistochemical study revealed positive staining using an antihuman IL-6 antibody and Northern analysis showed increased IL-6 mRNA levels in the tumour. Cultured tumour cells showed IL-6 protein synthesis, and nonsteroidal anti-inflammatory drugs such as naproxen and indomethacin directly inhibited IL-6 release. These results indicate that the effects of naproxen in vivo were due, at least in part, to direct suppression of IL-6 secretion from the tumour.
Shimizu
C
C
Department of Medicine II, Hokkaido University School of Medicine, Sapporo, Japan.
Kubo
M
M
Takano
K
K
Takano
A
A
Kijima
H
H
Saji
H
H
Katsuyama
I
I
Sasano
H
H
Koike
T
T
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D015152:Blotting, Northern; D003864:Depression, Chemical; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D015850:Interleukin-6 / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D009288:Naproxen / Q000494:pharmacology / Q000627:therapeutic use*; D009363:Neoplasm Proteins / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D010673:Pheochromocytoma / Q000188:drug therapy / Q000276:immunology* / Q000601:surgery; D012333:RNA, Messenger / Q000032:analysis; D014407:Tumor Cells, Cultured
D000894:Anti-Inflammatory Agents, Non-Steroidal; D015850:Interleukin-6; D009363:Neoplasm Proteins; D012333:RNA, Messenger; D009288:Naproxen