title: [Effectiveness of the combination of alpha tocopherol, rutin, melilotus, and centella asiatica in the treatment of patients with chronic venous insufficiency].
abstract: BACKGROUND
  The aim of this comparative clinical study was to evaluate the efficacy of the association of alphatocopherol, rutin, melilotus officinalis, and centella asiatica with oral administration in patients with chronic venous insufficiency.
  
  
  METHODS
  Thirty patients with chronic venous insufficiency have been randomized in two groups of fifteen subjects (control and treatment group). During the period of treatment the patients didn't wear elastocompressive stockings. The therapeutic efficacy and the clinical tolerability of this association have been valued with clinical-instrumental evaluations and by a control after 15 and 30 days. Functional bothers, cramps and the edema have been valued in function presence and of their gravity with a clinical-score between 0 and 4.
  
  
  RESULTS
  At the end of the observation period, a significant improvement of the clinical simptomatology was obtained, characterised by a diminution of the sovrafascial edema.
  
  
  CONCLUSIONS
  The present study confirms previous clinical experiences regarding the described treatment and suggests its application in chronic venous insufficiency.
authors: Unità Operativa Chirurgia Vascolare, Arcispedale S. Anna, Turin, Italy. alberto.cataldi@galactica.it
authors: A
authors: A
authors: Cataldi
authors: V
authors: V
authors: Gasbarro
authors: R
authors: R
authors: Viaggi
authors: R
authors: R
authors: Soverini
authors: E
authors: E
authors: Gresta
authors: F
authors: F
authors: Mascoli
mesh_terms: D000975:Antioxidants / Q000627:therapeutic use*; D028041:Centella; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006801:Humans; D029903:Melilotus; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D012431:Rutin / Q000627:therapeutic use*; D014689:Venous Insufficiency / Q000188:drug therapy*; D024502:alpha-Tocopherol / Q000627:therapeutic use*
chemical_list: D000975:Antioxidants; D010936:Plant Extracts; D012431:Rutin; D024502:alpha-Tocopherol