Proton magnetic resonance spectroscopy (H-MRS) studies of schizophrenia.
Proton magnetic resonance spectroscopy ((1)H-MRS) is a noninvasive technique that can quantify biochemical compounds in the brain. (1)H-MRS has been used to investigate neural structures implicated in the pathology of schizophrenia. The majority of research has revealed reduced N-acetylaspartate (NAA), an index of neuronal integrity, in frontal and temporal regions of medicated and chronically ill patients with schizophrenia. This review summarizes basic principles of (1)H-MRS, studies of frontal, temporal, subcortical, and cerebellar regions in schizophrenia. Technical and study design limitations are also discussed.
Rowland
L
L
Department of Psychiatry, University of New Mexico, Albuquerque, NM 87131, USA.
Bustillo
J R
JR
Lauriello
J
J
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D001923:Brain Chemistry; D002908:Chronic Disease; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D012559:Schizophrenia / Q000378:metabolism* / Q000503:physiopathology; D013702:Temporal Lobe / Q000378:metabolism*
D001224:Aspartic Acid; D006859:Hydrogen; C000179:N-acetylaspartate