Prenatal diagnosis of congenital nephrosis by in utero kidney biopsy.
The diagnosis of congenital nephrosis is difficult during the antepartum period. The combination of an elevated amniotic fluid alpha-fetoprotein, a negative acetylcholinesterase, and a negative ultrasound examination is highly indicative of congenital nephrosis; however, these findings can also be associated with a normal gestation. This is the first report of pathologic confirmation of congenital nephrosis from an in utero fetal kidney biopsy.
Wapner
R J
RJ
Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107-5083, USA.
Jenkins
T M
TM
Silverman
N
N
Kaufmann
M
M
Hannau
C
C
McCue
P
P
D000110:Acetylcholinesterase / Q000032:analysis; D000328:Adult; D000653:Amniotic Fluid / Q000737:chemistry; D001706:Biopsy; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000473:pathology; D005865:Gestational Age; D006801:Humans; D007668:Kidney / Q000473:pathology*; D009401:Nephrosis / Q000151:congenital / Q000175:diagnosis* / Q000473:pathology; D011247:Pregnancy; D011296:Prenatal Diagnosis; D016216:Ultrasonography, Prenatal; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins; D000110:Acetylcholinesterase