title: Clinical long-term results of vascular prosthesis sealed with fragmented autologous adipose tissue.
abstract: Tissue engineering can improve the former limitations of artificial organs. This article reports the long-term clinical results of grafts constructed with fragmented autologous adipose tissue. We did a retrospective analysis of a series of 53 patients with lower leg ischemia that received 69 fragmented adipose tissue (FAT) grafts implantation at our institution. The mean follow-up period was 36.0 months. After 1, 2, 3, and 5 years, the primary potency rates were 85.3, 83.3, 73.8, and 67.7%, respectively. The lumen of occluded areas not only at anastomotic sites but also in areas far from the anastomotic sites was occupied by a thickened neointima, which had a great number of capillary blood vessels, elastic laminae, smooth muscle cells, fibroblasts, and collagen fibers. This type of intimal hyperplasia was a characteristic finding in the FAT grafts. From the results of this clinical trial, we conclude that the FAT grafts are acceptable as vascular prostheses for ischemic lower extremities. The intimal hyperplasia at sites far from the anastomotic lines suggested the possibility of neointima formation throughout the luminal surface of the grafts.
authors: Department of Cardiovascular Surgery, Saiseikai Yokohama City Nanbu Hospital, Yokohama, Japan.
authors: N
authors: N
authors: Karube
authors: T
authors: T
authors: Soma
authors: Y
authors: Y
authors: Noishiki
authors: I
authors: I
authors: Yamazaki
authors: T
authors: T
authors: Kosuge
authors: Y
authors: Y
authors: Ichikawa
authors: Y
authors: Y
authors: Takanashi
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000368:Aged; D001698:Biomedical Engineering; D001807:Blood Vessel Prosthesis; D019917:Blood Vessel Prosthesis Implantation / Q000379:methods*; D005260:Female; D006801:Humans; D007511:Ischemia / Q000601:surgery; D007866:Leg / Q000098:blood supply*; D015993:Life Tables; D008297:Male; D011093:Polyethylene Terephthalates; D011183:Postoperative Complications; D012189:Retrospective Studies; D017539:Tunica Intima / Q000166:cytology; D014654:Vascular Patency
chemical_list: D011093:Polyethylene Terephthalates