title: Issues related to the decennial tetanus-diphtheria toxoid booster recommendations in adults.
abstract: In terms of disease prevention, reduction of adverse reactions, and cost benefit studies, a strong case can be made for a policy that focuses on assuring high levels of primary immunization with tetanus and diphtheria (Td) toxoids and abandons the decennial Td booster in favor of a single midlife booster at age 50-65 years. The addition of acellular pertussis antigens to Td for routine use in adults has potential problems in terms of schedule, cost, and possible adverse reactions. Careful risk/benefit studies are necessary to evaluate its effectiveness and priority.
authors: Department of Medicine, State University of New York at Stony Brook, Stony Brook, New York, USA.
authors: P
authors: P
authors: Gardner
mesh_terms: D000328:Adult; D004165:Diphtheria / Q000453:epidemiology / Q000517:prevention & control*; D022422:Diphtheria-Tetanus Vaccine / Q000008:administration & dosage; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D013742:Tetanus / Q000453:epidemiology / Q000517:prevention & control*; D014481:United States / Q000453:epidemiology; D014611:Vaccination
chemical_list: D022422:Diphtheria-Tetanus Vaccine