Bile acid-oligodeoxynucleotide conjugates: synthesis and liver excretion in rats.
The synthesis of bile acid oligodeoxynucleotide conjugates via the 3-OH group of the bile acids is described. When used in vivo in rats, covalent conjugation of an oligodeoxynucleotide via a linker to cholic acid resulted in an increased biliary excretion of bile acid-oligodeoxynucleotide conjugates compared to unconjugated oligodeoxynucleotides.
Starke
D
D
Institute of Pharmacology and Toxicology, Justus-Liebig-University, Giessen, Germany.
Lischka
K
K
Pagels
P
P
Uhlmann
E
E
Kramer
W
W
Wess
G
G
Petzinger
E
E
D000818:Animals; D001647:Bile Acids and Salts / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics*; D022781:Hepatocytes / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D009838:Oligodeoxyribonucleotides / Q000737:chemistry* / Q000378:metabolism / Q000493:pharmacokinetics*; D051381:Rats; D017208:Rats, Wistar
D001647:Bile Acids and Salts; D009838:Oligodeoxyribonucleotides