title: Regulation of translation initiation by FRAP/mTOR.
authors: Department of Biochemistry, McGill University, Montréal, Québec H3G 1Y6, Canada.
authors: A C
authors: AC
authors: Gingras
authors: B
authors: B
authors: Raught
authors: N
authors: N
authors: Sonenberg
mesh_terms: D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001665:Binding Sites; D002352:Carrier Proteins / Q000378:metabolism; D002455:Cell Division / Q000235:genetics / Q000502:physiology; D002867:Chromones / Q000494:pharmacology; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics / Q000378:metabolism; D004734:Energy Metabolism / Q000235:genetics; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005057:Eukaryotic Cells / Q000187:drug effects / Q000378:metabolism; D039603:Eukaryotic Initiation Factor-4G; D039642:Eukaryotic Initiation Factors; D005656:Fungal Proteins / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology; D046911:Macromolecular Substances; D008322:Mammals / Q000235:genetics / Q000378:metabolism; D051379:Mice; D009025:Morpholines / Q000494:pharmacology; D009363:Neoplasm Proteins / Q000037:antagonists & inhibitors; D051059:PTEN Phosphohydrolase; D010446:Peptide Fragments / Q000378:metabolism; D010448:Peptide Initiation Factors / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases / Q000502:physiology; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010749:Phosphoprotein Phosphatases / Q000378:metabolism; D010744:Phosphoric Monoester Hydrolases / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects / Q000502:physiology; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D017346:Protein Serine-Threonine Kinases; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D051057:Proto-Oncogene Proteins c-akt; D012333:RNA, Messenger / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D015398:Signal Transduction / Q000187:drug effects; D020123:Sirolimus / Q000494:pharmacology; D013045:Species Specificity; D013329:Structure-Activity Relationship; D058570:TOR Serine-Threonine Kinases; D022061:Tacrolimus Binding Protein 1A / Q000378:metabolism; D025521:Tumor Suppressor Proteins; D000077191:Wortmannin
chemical_list: D000730:Androstadienes; D000970:Antineoplastic Agents; D002352:Carrier Proteins; D002867:Chromones; D029721:Drosophila Proteins; D004791:Enzyme Inhibitors; D039603:Eukaryotic Initiation Factor-4G; D039642:Eukaryotic Initiation Factors; D005656:Fungal Proteins; D019476:Insect Proteins; D007328:Insulin; D046911:Macromolecular Substances; D009025:Morpholines; D009363:Neoplasm Proteins; D051059:PTEN Phosphohydrolase; D010446:Peptide Fragments; D010448:Peptide Initiation Factors; D019869:Phosphatidylinositol 3-Kinases; D000081082:Phosphoinositide-3 Kinase Inhibitors; D010749:Phosphoprotein Phosphatases; D010744:Phosphoric Monoester Hydrolases; D017853:Phosphotransferases (Alcohol Group Acceptor); D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; D012333:RNA, Messenger; D029701:Saccharomyces cerevisiae Proteins; D020123:Sirolimus; D058570:TOR Serine-Threonine Kinases; D022061:Tacrolimus Binding Protein 1A; D025521:Tumor Suppressor Proteins; D000077191:Wortmannin; C491255:Eif4ebp2 protein, mouse; C491908:Eif4g1 protein, mouse; C107740:TIF4631 protein, S cerevisiae; C031799:eIF-4B; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; C416303:target of rapamycin protein, Drosophila; C546843:mTOR protein, mouse