title: Chronic inflammatory bowel disease in a patient with common variable immunodeficiency.
abstract: Common variable immunodeficiency (CVID) is a primary defect of the immune system involving an increased risk of respiratory and digestive tract infections and autoimmune diseases. Recently, it has been reported that chronic inflammatory bowel disease (CIBD) might occur with increased frequency (20%) in patients with CVID. A nine-year-old boy with CVID developed CIBD during follow-up and periodic intravenous immunoglobulin administration. Serum tumor necrosis factor-a concentration, which is suggested to show disease activity in CBD, was very high. The patient's radiological evaluation, both in active and remission periods, had characteristic features of CBD. We herewith present and discuss this case with both diseases, CVID and CIBD.
authors: Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
authors: N
authors: N
authors: Kütükçüler
authors: R V
authors: RV
authors: Yağci
authors: S
authors: S
authors: Aydoğdu
authors: G
authors: G
authors: Aksu
authors: B
authors: B
authors: Genç
mesh_terms: D002648:Child; D002908:Chronic Disease; D017074:Common Variable Immunodeficiency / Q000150:complications*; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D011859:Radiography; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
chemical_list: D014409:Tumor Necrosis Factor-alpha