[Clozapine-induced toxic hepatitis].
A case of clozapine-induced toxic hepatitis in a 49-year old woman with schizophrenia is described. The daily clozapine dose was clinically titrated to 300 mg. Subsequently, the patient experienced lethargy and anorexia, and fever, eosinophilia, leucocytosis and abnormal liver parameters were found. The serum concentration of clozapine was 8595 nmol/l, and treatment was discontinued. After eight days, the condition stabilised, and low-dose clozapine treatment was successfully reinstituted with serum monitoring (TDM).
Larsen
J T
JT
Odense Universitetshospital, afdeling KKA, sektion for klinisk farmakologi og psykiatrisk afdeling P.
Clemensen
S V
SV
Klitgaard
N A
NA
Nielsen
B
B
Brøsen
K
K
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D012559:Schizophrenia / Q000188:drug therapy
D003024:Clozapine