Fitting the log-F accelerated failure time model with incomplete covariate data.
Data obtained from studies in the health sciences often have incompletely observed covariates as well as censored outcomes. In this paper, we present methods for fitting the log-F accelerated failure time model with incomplete continuous and/or categorical time-independent covariates using the Gibbs sampler. A general location model that allows different covariance structures across cells is specified for the covariates, and ignorable missingness of the covariates is assumed. Techniques that accommodate standard assumptions of ignorable censoring as well as certain types of nonignorable censoring are developed. We compare our approach to traditional complete-case analysis in an application to data obtained from a study of melanoma. The comparison indicates that substantial gains in efficiency are possible with our approach.
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Department of Clinical Biostatistics and Research Data Systems, Merck Research Laboratories, Merck & Co., Inc., Rahway, New Jersey 07065, USA.
Schenker
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D001699:Biometry; D003627:Data Interpretation, Statistical; D006801:Humans; D016014:Linear Models; D008545:Melanoma / Q000401:mortality / Q000473:pathology; D015233:Models, Statistical; D011379:Prognosis; D016019:Survival Analysis