Lessons from anticancer research might provide new insights into mechanisms of hormone action.
The extent to which specific anticancer drugs induce apoptosis in tumors frequently predicts the success of chemotherapy for a particular type of cancer. Recent results from experiments designed to evaluate drug-induced apoptosis in colon cancer cells revealed that the levels of BCL-2-related apoptotic suppressor proteins were dramatically reduced compared with those of pro-apoptotic proteins. In the case of nonsteroidal anti-inflammatory drugs, this might be a consequence of inhibition of the cyclooxygenase-mediated production of prostaglandins.
Buckley
A R
AR
College of Pharmacy, University of Cincinnati Medical Center, 3223 Eden Ave, PO Box 670004, Cincinnati, OH 45267-0004, USA. Arthur.Buckley@uc.edu
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D003110:Colonic Neoplasms / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D004967:Estrogens / Q000378:metabolism / Q000494:pharmacology; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D011374:Progesterone / Q000378:metabolism / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism; D011518:Proto-Oncogene Proteins / Q000187:drug effects / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000187:drug effects / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D051028:bcl-2-Associated X Protein
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004967:Estrogens; D006728:Hormones; D011453:Prostaglandins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein; D011374:Progesterone