Influenza and human immunodeficiency virus infection: absence of HIV progression after acute influenza infection.
Influenza is a major cause of morbidity for people with significant underlying disease, but the impact of influenza on people infected with human immunodeficiency virus (HIV) remains unclear. We studied a population of HIV-infected adults during the 1998-1999 influenza season to see whether influenza had any adverse effects on the course of HIV infection. During 5 months of follow-up, we found no unique clinical manifestations or negative impact on CD4(+) cell count, virus load, or clinical progression of HIV disease. Although half of our cohort received antibiotic therapy, none received specific anti-influenza therapy and none required hospitalization. Acute influenza does not appear to be a risk for progression of HIV disease.
Golden
M P
MP
Departments of Medicine and Infectious Diseases, Hospital of Saint Raphael, and Yale University School of Medicine, New Haven, CT 06511, USA. mgolden@srhs.org
Sajjad
Z
Z
Elgart
L
L
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D000208:Acute Disease; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D018791:CD4 Lymphocyte Count; D015224:Dideoxynucleosides / Q000627:therapeutic use; D004196:Disease Outbreaks; D018450:Disease Progression; D005260:Female; D006801:Humans; D007252:Influenza Vaccines; D007251:Influenza, Human / Q000188:drug therapy / Q000453:epidemiology / Q000503:physiopathology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D018894:Reverse Transcriptase Inhibitors / Q000627:therapeutic use; D000099227:Abacavir
D019380:Anti-HIV Agents; D015224:Dideoxynucleosides; D007252:Influenza Vaccines; D018894:Reverse Transcriptase Inhibitors; D000099227:Abacavir