(+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice.
Cocaine interacts with sigma receptors at physiologically relevant concentrations. While earlier studies demonstrate that antagonism of sigma(1) receptors attenuates the behavioral actions of cocaine, the contribution of sigma(2) receptors is unclear. Therefore, in the present study, 3 alpha-tropanyl-2-(4-chlorophenoxy)butyrate ((+/-)-SM 21), a compound with high and preferential affinity for sigma(2) receptors, was tested for its ability to attenuate cocaine-induced behaviors. Pre-treatment of Swiss Webster mice with (+/-)-SM 21 significantly attenuated cocaine-induced convulsions and locomotor activity.
Matsumoto
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Department of Pharmaceutical Sciences, College of Pharmacy, University of Oklahoma Health Sciences Center, P.O. Box 26901, CPB 337 73190, Oklahoma City, OK, USA. rae-matsumoto@ouhsc.edu
Mack
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D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002087:Butyrates / Q000494:pharmacology*; D003042:Cocaine / Q000494:pharmacology*; D018765:Dopamine Uptake Inhibitors / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D012640:Seizures / Q000517:prevention & control*; D013997:Time Factors; D014326:Tropanes / Q000494:pharmacology*
D000700:Analgesics; D002087:Butyrates; D018765:Dopamine Uptake Inhibitors; D014326:Tropanes; C107044:SM 21; D003042:Cocaine