Role of chance in familial aggregation of colorectal cancer.
A prospective population-based study recorded family trees of 77 colorectal cancer patients younger than 50 years of age. Using mathematical modeling of population age-incidence data, we estimate that 1 (95% confidence limits 0 and 3) of these families is expected to meet the Amsterdam criteria I for HNPCC due to chance clustering of colorectal cancer.
Katballe
N
N
Surgical Research Unit 900, Department or Surgery L, Aarhus University Hospital, Aarhus Amtssygehus, Aarhus, Denmark.
Bentzen
S M
SM
Christensen
M
M
Wikman
F P
FP
Ørntoft
T
T
Laurberg
S
S
D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics*; D003718:Denmark; D005192:Family Health; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011336:Probability; D011446:Prospective Studies