A novel mucoadhesive polymer prepared by template polymerization of acrylic acid in the presence of chitosan.
A novel mucoadhesive polymer was prepared by template polymerization of acrylic acid in the presence of chitosan for transmucosal drug delivery system (TMD). FT-IR results indicated that polymer complex was formed between poly(acrylic acid) (PAA) and chitosan through hydrogen bonding. Glass transition temperature (Tg) of chitosan and PAA in the PAA/chitosan polymer complexes was inner-shifted compared with Tg of chitosan and PAA itself. This may be due to the increased miscibility of PAA with chitosan through the hydrogen bonding. The crystallinity of chitosan in the PAA/chitosan polymer complexes was decreased with polymer complex formation with PAA. The dissolution rate of the PAA/chitosan polymer complex was dependent on pH and ratio of PAA/chitosan. The mucoadhesive force of PAA/chitosan polymer complex was similar to a commericial product, Carbopol 971P NF.
Ahn
J S
JS
School of Agricultural Biotechnology, Seoul National University, Kwonsun-gu, Suwon, South Korea.
Choi
H K
HK
Cho
C S
CS
D000179:Acrylates / Q000737:chemistry*; D000269:Adhesives / Q000737:chemistry*; D002686:Chitin / Q000031:analogs & derivatives / Q000737:chemistry*; D048271:Chitosan; D006860:Hydrogen Bonding; D011108:Polymers; D017550:Spectroscopy, Fourier Transform Infrared; D014961:X-Ray Diffraction
D000179:Acrylates; D000269:Adhesives; D011108:Polymers; D002686:Chitin; D048271:Chitosan; C036658:acrylic acid