Beta-fibrinogen gene -455G/A polymorphism and coronary heart disease incidence: the Atherosclerosis Risk in Communities (ARIC) Study.
OBJECTIVE
The -455G/A (HaeIII) polymorphism of the beta-fibrinogen gene influences levels of plasma fibrinogen. We determined whether it influences risk of coronary heart disease.


METHODS
We conducted a case-cohort study nested within a prospective investigation, the Atherosclerosis Risk in Communities Study. We accumulated 398 incident coronary heart disease cases over a median of 5.3 years of follow-up and compared their -455G/A status with a random sample of the cohort (n = 498).


RESULTS
Plasma fibrinogen was higher (p = 0.04) in AA homozygous participants (341 mg/dL) than in persons carrying the G allele: GA (290 mg/dL), GG (298 mg/dL). However, there was no significant association between -455G/A and incident CHD.


CONCLUSIONS
Although a small effect cannot be excluded, -455G/A does not appear to be an important genetic determinant of CHD.
Folsom
A R
AR
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis, MN 55454-1015, USA.
Aleksic
N
N
Ahn
C
C
Boerwinkle
E
E
Wu
K K
KK
D000225:Adenine; D000483:Alleles; D001161:Arteriosclerosis / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D015331:Cohort Studies; D003327:Coronary Disease / Q000097:blood / Q000453:epidemiology* / Q000235:genetics; D005340:Fibrinogen / Q000032:analysis / Q000235:genetics*; D005838:Genotype; D006147:Guanine; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D011446:Prospective Studies; D012307:Risk Factors; D014481:United States / Q000453:epidemiology
D006147:Guanine; D005340:Fibrinogen; D000225:Adenine