title: Lipid and lipoprotein responses to oral combined hormone replacement therapy in normolipemic obese women with controlled type 2 diabetes mellitus.
abstract: This study investigated the effects of oral combined hormone replacement therapy (OCHRT) on lipid concentrations and subpopulation distribution of lipoproteins in nine postmenopausal women with type 2 diabetes mellitus and moderate glycemic control. After 16 weeks of continuous daily therapy of conjugated estrogens 0.625 mg and medroxyprogesterone 2.5 mg, the mean concentration of high-density lipoprotein (HDL) cholesterol showed a statistically significant increase of 16.7%, predominantly in the HDL2 subfraction. No statistically significant changes in mean concentrations of total cholesterol, low-density lipoprotein (LDL) cholesterol, triglycerides, very low-density lipoprotein (VLDL) triglycerides, apolipoprotein A1, or apolipoprotein B were evident. Likewise, no changes were found in the average diameter of VLDL, LDL, or HDL particles; triglyceride concentrations of VLDL subfractions; cholesterol concentrations of LDL subfractions; or chemical composition of plasma LDL. These findings lend further support to the use of OCHRT in postmenopausal women with diabetes to decrease their risk for coronary artery disease.
authors: Department of Family Medicine, East Carolina University School of Medicine, 600 Moye Blvd, Brody 4N-51, Greenville, NC 27858, USA.
authors: S H
authors: SH
authors: Lilley
authors: J M
authors: JM
authors: Spivey
authors: S
authors: S
authors: Vadlamudi
authors: J
authors: J
authors: Otvos
authors: D M
authors: DM
authors: Cummings
authors: H
authors: H
authors: Barakat
mesh_terms: D000284:Administration, Oral; D000368:Aged; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D015914:Estrogen Replacement Therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008875:Middle Aged; D009765:Obesity / Q000097:blood*; D010316:Particle Size
chemical_list: D006442:Glycated Hemoglobin; D008055:Lipids; D008074:Lipoproteins