Vascular integrin beta 3 and its relation to pulmonary metastasis of colorectal carcinoma.
Integrin alpha v-beta 3 is involved in tumor angiogenesis while the clinical significance of beta 3 integrin expression in colorectal cancer and lung metastases. Analysis was performed on 51 colorectal cancer patients (22 with subsequent lung metastasis and 29 without lung metastasis). Fifty-one primary tumors and 22 lung metastases were examined for immunohistochemical detection of integrin beta 3. We found that the antibody VNR 5 to integrin beta 3 prefentially stains the blood vessels of small caliber. Indeed, vascular integrin beta 3 index was significantly higher in tumors of patients with lung metastasis than in those without lung metastasis. In the patients with lung metastases, vascular integrin beta 3 index was significantly lower in lung metastases than in primary tumors. It was immunohistochemically proved that integrin beta 3 is an important vascular endothelial cell market for lung metastasis.
Sato
T
T
Department of Surgery, Toyama Prefectural Central Hospital 2-2-78 Nishinagae, Toyama, 930-8550, Japan. YIB03163@niftyserve.or.jp
Konishi
K
K
Kimura
H
H
Maeda
K
K
Yabushita
K
K
Tsuji
M
M
Miwa
A
A
D000230:Adenocarcinoma / Q000098:blood supply / Q000235:genetics / Q000401:mortality / Q000556:secondary*; D000328:Adult; D000368:Aged; D000782:Aneuploidy; D015703:Antigens, CD / Q000502:physiology*; D002465:Cell Movement; D015179:Colorectal Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D018572:Disease-Free Survival; D004730:Endothelium, Vascular / Q000378:metabolism*; D005260:Female; D006801:Humans; D039661:Integrin beta3; D008175:Lung Neoplasms / Q000098:blood supply / Q000401:mortality / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D010980:Platelet Membrane Glycoproteins / Q000502:physiology*; D011379:Prognosis
D015703:Antigens, CD; D004273:DNA, Neoplasm; D039661:Integrin beta3; D009363:Neoplasm Proteins; D010980:Platelet Membrane Glycoproteins