title: Carbon disulfide at a Chinese viscose factory external and internal exposure assessment.
abstract: This article presents the results of carbon disulfide exposure measurements in a Chinese viscose rayon factory. The objectives of the study were to identify the external exposure levels at a large factory and to investigate the 2-thiothiazolidine-4-carboxylic acid (TTCA) concentrations in the urine of the subjects who were exposed to carbon disulfide in the working place atmosphere. The metabolism of carbon disulfide in the exposed subjects was also studied in order to demonstrate the best points in time for the internal exposure sampling. The measurement of the amount of personal exposure to carbon disulfide in the air of the workplace was performed by GC-FPD; the presence of TTCA in the workers urine was analyzed by use of a modified HPLC method. The kinetics of TTCA excretion was studied by analyses at different time-points both during and after exposure to carbon disulfide in the subjects. A total of 155 personal samples were obtained. The carbon disulfide concentration in the staple viscose hall was 13.72 +/- 1.12 mg m-3 in terms of the geometric mean +/- geometric standard deviation, and was 20.05 +/- 1.33 mg m-3 in the filament spinning hall. The TTCA values in the subjects who worked in the staple spinning hall were 1.18 +/- 0.43 mg g-1 creatinine and 1.07 +/- 0.38 mg g-1 creatinine for subjects working in the filament spinning hall. The best time for TTCA sampling is at the end of the working shift, the TTCA excretion was stable for a period of 4-12 h after exposure of the subjects to the carbon disulfide. It might be that the Chinese have different anthropometric characteristics; a sampling bias may therefore appear among different races.
authors: Dept. of Public Health, Faculty of Medicine, Wuhan University, Wuhan 430071, China. xiaodong.tan@rug.ac.be
authors: X
authors: X
authors: Tan
authors: Y
authors: Y
authors: Bi
authors: Y
authors: Y
authors: Su
authors: Y
authors: Y
authors: Li
authors: J
authors: J
authors: He
authors: P
authors: P
authors: Yi
authors: J
authors: J
authors: Yan
authors: C
authors: C
authors: Wang
authors: F
authors: F
authors: Wang
authors: M
authors: M
authors: Vanhoorne
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000032:analysis*; D017554:Carbon Compounds, Inorganic / Q000032:analysis* / Q000493:pharmacokinetics; D002482:Cellulose; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm; D006801:Humans; D007221:Industry; D008297:Male; D008420:Manufactured Materials; D016273:Occupational Exposure; D013440:Sulfides / Q000032:analysis* / Q000493:pharmacokinetics; D013844:Thiazoles / Q000652:urine; D053778:Thiazolidines; D013997:Time Factors
chemical_list: D017554:Carbon Compounds, Inorganic; D013440:Sulfides; D013844:Thiazoles; D053778:Thiazolidines; C031677:2-thioxo-4-thiazolidinecarboxylic acid; C092035:carbon sulfide; D002482:Cellulose; C012024:rayon, purified