Symposium on the etiology of hypertension--summarizing studies in 20th century. 1. Hypertension and genes.
Under classical strategy, scientists have tried first to find a physiological phenomenon specific for essential hypertension, then to identify the protein underlying the physiological abnormality, and finally to clarify the causative gene which encoded the protein. On the other hand, under the reverse genetic approach, the correlation between hypertension and genetic abnormality is identified first, and then the pathogenesis is clarified-in reverse order. Therefore, it is not extraordinary for unexpected results to be obtained in the correlation between a gene and a disease, suggesting that this approach has a possibility to be a breakthrough in the chaos of hypertension research.
Higaki
J
J
The Department of Geriatric Medicine, Osaka University Medical School, Suita.
Katsuya
T
T
Morishita
R
R
Ogihara
T
T
D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D044466:Asian People / Q000235:genetics; D004195:Disease Models, Animal; D005786:Gene Expression Regulation; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D015316:Genetic Therapy; D006801:Humans; D006973:Hypertension / Q000145:classification / Q000208:ethnology / Q000235:genetics* / Q000503:physiopathology; D008081:Liposomes; D020319:Oligodeoxyribonucleotides, Antisense / Q000235:genetics / Q000627:therapeutic use; D012150:Polymorphism, Restriction Fragment Length; D051381:Rats; D011918:Rats, Inbred SHR; D012084:Renin-Angiotensin System / Q000235:genetics; D014162:Transfection; D044465:White People / Q000235:genetics
D008081:Liposomes; D020319:Oligodeoxyribonucleotides, Antisense; D000808:Angiotensinogen