The functional myosin light chain kinase (MYLK) gene localizes with marker D3S3552 on human chromosome 3q21 in a >5-Mb yeast artificial chromosome region and is not linked to olfactory receptor genes.
The myosin light chain kinase (MYLK) gene is duplicated on human chromosome 3 (3q13-->q21; 3p13), two sites known to contain olfactory receptor (OR) genes. The 3p13 site contains a MYLK pseudogene (MYLKP) associated with a cluster of OR pseudogenes and therefore could have arisen from the duplication of a large region in 3q13-->q21. Here, we present the localization of the MYLK gene in a >5-Mb region of the chromosome 3q21 integrated map. MYLK colocalizes with marker D3S3552. OR genes are absent from this region, suggesting that the 3p13 duplicated region incurred further rearrangements during evolution.
Giorgi
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Institut de Génétique Humaine, CNRS-UPR 1142, Montpellier, France.
Brand-Arpon
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Rouquier
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D022202:Chromosomes, Artificial, Bacterial / Q000235:genetics; D018244:Chromosomes, Artificial, Yeast / Q000235:genetics*; D002893:Chromosomes, Human, Pair 3 / Q000235:genetics*; D003360:Cosmids / Q000235:genetics; D019143:Evolution, Molecular; D020440:Gene Duplication; D020131:Genes, Duplicate / Q000235:genetics; D008040:Genetic Linkage / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D005810:Multigene Family / Q000235:genetics; D009219:Myosin-Light-Chain Kinase / Q000235:genetics*; D020161:Physical Chromosome Mapping; D011544:Pseudogenes / Q000235:genetics; D018035:Receptors, Odorant / Q000235:genetics*
D005819:Genetic Markers; D018035:Receptors, Odorant; D009219:Myosin-Light-Chain Kinase