title: An unusual melanocytic lesion associated with eccrine duct fibroadenomatosis and syringoid features.
abstract: The intimate association of nevomelanocytic nevi with eccrine ducts commonly seen in congenital nevi was emphasized by Mishima, who described as eccrine-centered nevi those lesions characterized by nevomelanocytic cells predominantly proliferating around and within the eccrine sweat duct walls. However, there were no changes in the overlying epidermis, dermis, or eccrine acrosyringeal or dermal duct proliferation in these lesions. We present the case of a 16-year-old boy with a 1-year-history of a 0.6-cm diameter single tan papule on the right heel, clinically thought to be a Spitz nevus. Histopathologic examination revealed a compound nevomelanocytic nevus associated with epidermal hyperplasia, thin anastomosing cords of acrosyringeal epithelium extending within the dermis, and eccrine ductal proliferation in a syringoma-like pattern associated with a dense fibrous stroma. Features that distinguish our case from eccrine-centered nevus are that the latter lacks epidermal and eccrine duct hyperplasia and a dense fibrous stroma. The location of the lesion on the heel in our case suggests the possibility that the pathologic changes observed could result from repetitive trauma.
authors: Dermatopathology Section, Department of Dermatology, Boston University School of Medicine, Boston, Massachusetts 02118, USA.
authors: C M
authors: CM
authors: Stefanato
authors: D A
authors: DA
authors: Simkin
authors: J
authors: J
authors: Bhawan
mesh_terms: D006607:Adenoma, Sweat Gland / Q000737:chemistry / Q000473:pathology*; D000293:Adolescent; D014408:Biomarkers, Tumor / Q000032:analysis; D004439:Eccrine Glands / Q000737:chemistry / Q000473:pathology*; D005350:Fibroma / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007124:Immunoenzyme Techniques; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D009508:Nevus, Pigmented / Q000737:chemistry / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor