Expression of connexin 30 in the developing mouse cochlea.
Mutations in the GJB6 gene encoding connexin 30 (Cx30) can cause dominant forms of nonsyndromic deafness. By studying immunohistochemical localization of Cx30 in the mouse cochlea at different ages from 0 to 30 days after birth, we found that the expression of Cx30 is nearly the same as that of Cx26. These findings suggest that as well as Cx26, Cx30 may also contribute to the generation and maturation of endocochlear potential.
Xia
A
A
Department of Otorhinolaryngology-Head and Neck Surgery, Tohoku University Graduate School of Medicine, 1-1 Seiryo-machi, Aoba-ku, 980-8574, Sendai, Japan. ka@orl.med.tohoku.ac.jp
Katori
Y
Y
Oshima
T
T
Watanabe
K
K
Kikuchi
T
T
Ikeda
K
K
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D003051:Cochlea / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D000075302:Connexin 30; D017630:Connexins / Q000235:genetics / Q000378:metabolism*; D018076:DNA, Complementary; D003638:Deafness / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D004710:Endolymph / Q000378:metabolism; D017629:Gap Junctions / Q000378:metabolism*; D006309:Hearing / Q000502:physiology; D007150:Immunohistochemistry; D008564:Membrane Potentials / Q000502:physiology; D051379:Mice; D008808:Mice, Inbred CBA / Q000033:anatomy & histology / Q000254:growth & development* / Q000378:metabolism; D010498:Perilymph / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction
D000075302:Connexin 30; D017630:Connexins; D018076:DNA, Complementary; C100629:Gjb6 protein, mouse; D011188:Potassium