title: Genome screening for linkage disequilibrium in a Costa Rican sample of patients with bipolar-I disorder: a follow-up study on chromosome 18.
abstract: Linkage disequilibrium (LD) methods offer great promise for mapping complex traits, but have thus far been applied sparingly. In this paper we describe an LD mapping study of severe bipolar disorder (BP-I) in the genetically isolated population of the Central Valley of Costa Rica. This study provides the first complete screen of a chromosome for a complex trait using LD mapping and presents the first application of a new LD mapping statistic (ancestral haplotype reconstruction (AHR)) that evaluates haplotype sharing among affected individuals. The results of this chromosome-wide analysis are instructive for genome-wide LD mapping in isolated populations. Furthermore, the analysis continues to support a possible BP-I locus on 18pter, suggested by previous analyses in this population. Evidence for a possible BP-I locus on 18q12.2 is also described.
authors: Neurogenetics Laboratory, University of California at San Francisco, San Francisco, California, USA.
authors: M A
authors: MA
authors: Escamilla
authors: L A
authors: LA
authors: McInnes
authors: S K
authors: SK
authors: Service
authors: M
authors: M
authors: Spesny
authors: V I
authors: VI
authors: Reus
authors: J
authors: J
authors: Molina
authors: A
authors: A
authors: Gallegos
authors: E
authors: E
authors: Fournier
authors: S
authors: S
authors: Batki
authors: T
authors: T
authors: Neylan
authors: C
authors: C
authors: Matthews
authors: S
authors: S
authors: Vinogradov
authors: E
authors: E
authors: Roche
authors: D J
authors: DJ
authors: Tyler
authors: N
authors: N
authors: Shimayoshi
authors: R
authors: R
authors: Mendez
authors: R
authors: R
authors: Ramirez
authors: M
authors: M
authors: Ramirez
authors: C
authors: C
authors: Araya
authors: X
authors: X
authors: Araya
authors: P E
authors: PE
authors: Leon
authors: L A
authors: LA
authors: Sandkuijl
authors: N B
authors: NB
authors: Freimer
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002887:Chromosomes, Human, Pair 18; D003364:Costa Rica; D005500:Follow-Up Studies; D005819:Genetic Markers; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D008957:Models, Genetic
chemical_list: D005819:Genetic Markers