title: A pregnane steroid from Aglaia lawii and structure confirmation of cabraleadiol monoacetate by X-ray crystallography.
abstract: The pregnane steroid, (E)-aglawone, along with four known triterpenes, and a known sterol mixture were isolated from the bark of Aglaia lawii (Wight) Saldanha ex Ramamoorty (Meliaceae). The structural determination/identification was accomplished by a combination of 1D- and 2D-NMR spectroscopic techniques. The relative stereochemistry of the known triterpene, 20S,24S-epoxydammarane-3alpha,25-diol acetate, was also unequivocally determined for the first time by X-ray crystallography. The isolates were not active against various human cancer cell lines.
authors: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, 60612, USA.
authors: S X
authors: SX
authors: Qiu
authors: V H
authors: VH
authors: Nguyen
authors: T X
authors: TX
authors: Le
authors: J Q
authors: JQ
authors: Gu
authors: E
authors: E
authors: Lobkovsky
authors: C K
authors: CK
authors: Tran
authors: D D
authors: DD
authors: Soejarto
authors: J
authors: J
authors: Clardy
authors: J M
authors: JM
authors: Pezzuto
authors: Y
authors: Y
authors: Dong
authors: V T
authors: VT
authors: Mai
authors: M H
authors: MH
authors: Le
authors: H H
authors: HH
authors: Fong
mesh_terms: D018360:Crystallography, X-Ray; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010840:Phytosterols / Q000737:chemistry* / Q000302:isolation & purification; D018547:Plant Stems / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011278:Pregnanes / Q000737:chemistry* / Q000302:isolation & purification
chemical_list: D010840:Phytosterols; D011278:Pregnanes; C430224:cabraleadiol monoacetate