Natural polyamines and their biological consequence in mammals.
The polyamines (putrescine, cadaverine, agmatine, spermidine and spermine), wide-spread in all organisms, have been shown to play a role in regulation of growth and differentiation of virtually all types of cells. Their role in many physiological and pathophysiological processes have been studied very intensively during the last two decades. Inhibitors of polyamine biosynthesis have potential clinical uses as antitumor and antiparasitic agents. The brief summary with regard to their biological consequences in mammals is discussed in this paper.
Patocka
J
J
Department of Toxicology, Military Medical Academy, Hradec Králové. patocka@pmfhk.cz
Kuehn
G D
GD
D000376:Agmatine / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D015317:Biogenic Polyamines / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology*; D002103:Cadaverine / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D011700:Putrescine / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D013095:Spermidine / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology; D013096:Spermine / Q000737:chemistry / Q000494:pharmacology / Q000502:physiology
D015317:Biogenic Polyamines; D013096:Spermine; D000376:Agmatine; D002103:Cadaverine; D013095:Spermidine; D011700:Putrescine