Skin function and skin disorders in Parkinson's disease.
Cutaneous symptoms (seborrhoea and hyperhidrosis) in Parkinson's disease were investigated. In 70 treated patients with Parkinson's disease and 22 control subjects, non-invasive bioengineering methods (sebumetry, corneometry, pH) were carried out on the forehead, sternum and forearm. In addition, concomitant dermatoses and medication were recorded. 18.6% of the patients had seborrhoea on the forehead (>220 microg/cm2), 51.4% showed normal sebum values (100-220 microg/cm2) and 30% a sebostasis (<100 microg/cm2). Males has significantly higher sebum values than females. No relationship between the seborrhoea and the therapy for Morbus Parkinson was found. Patients with hyperhidrosis (n = 36) had significantly lower pH values (p < 0.05) on the forehead than those without hyperhidrosis. 22 patients (31.9%) reported a cold/hot flush and a further 13 (18.8%) had clinical rosacea. Seborrhoea is rare in treated Parkinsonian patients but hyperhidrosis is frequently found. Furthermore, a particular lack of vasostability (flush) appears to be an autonomic dysregulation in the skin related to Morbus Parkinson, which has not been studied to any extent to date.
Fischer
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Department of Dermatology and Venerology, Martin-Luther-University, Halle, Saale, Federal Republic of Germany. matthias.fischer@medizin.uni-halle.de
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D000368:Aged; D012628:Dermatitis, Seborrheic / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D006945:Hyperhidrosis / Q000209:etiology* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology; D012393:Rosacea / Q000209:etiology / Q000503:physiopathology; D012629:Sebum / Q000378:metabolism; D012867:Skin / Q000378:metabolism / Q000503:physiopathology