title: Cyclosporine-associated thrombotic microangiopathy during daclizumab induction: a suggested therapeutic approach.
abstract: A woman on daclizumab developed thrombotic microangiopathy secondary to cyclosporine after a living-unrelated kidney transplant. Despite cyclosporine discontinuation, hemolysis persisted. The second dose of daclizumab was postponed 24 h, and after a maximum of two sessions of plasmapheresis (to avoid further modifications in daclizumab schedule) with plasma exchange, daclizumab was administered. Plasma infusions were prescribed until D-dimer and fibrinogen-degradation products normalized; thereafter, FK-506 was started without recurrence of the hemolytic picture and renal function restored. This observation suggests that in patients on daclizumab who develop thrombotic microangiopathy secondary to immunosuppressants, if discontinuation of the offending drug is unsuccessful, plasmapheresis with plasma exchange can be performed when the lowest levels of daclizumab exist, followed by daclizumab infusion. Plasma prescription must be continued thereafter until D-dimer and figrinogen-degradation products normalize. However, if hemolysis persists when daclizumab levels are high, plasma infusions are useful and plasmapheresis avoided. FK-506 administration did not result in recurrence of hemolysis during daclizumab induction.
authors: Nephrology Section, British Hospital, Buenos Aires, Argentina. htrimarchi@hotmail.com
authors: H
authors: H
authors: Trimarchi
authors: E
authors: E
authors: Freixas
authors: O
authors: O
authors: Rabinovich
authors: J
authors: J
authors: Schropp
authors: H
authors: H
authors: Pereyra
authors: E
authors: E
authors: Bullorsky
mesh_terms: D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D061067:Antibodies, Monoclonal, Humanized; D015415:Biomarkers / Q000097:blood; D016913:Blood Component Transfusion; D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood; D000077561:Daclizumab; D004359:Drug Therapy, Combination; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D007074:Immunoglobulin G / Q000627:therapeutic use*; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000601:surgery; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology / Q000502:physiology; D019520:Living Donors; D008297:Male; D008833:Microcirculation / Q000473:pathology*; D008875:Middle Aged; D010956:Plasmapheresis; D007690:Polycystic Kidney Diseases / Q000150:complications; D016559:Tacrolimus / Q000627:therapeutic use; D013927:Thrombosis / Q000139:chemically induced* / Q000628:therapy
chemical_list: D000911:Antibodies, Monoclonal; D061067:Antibodies, Monoclonal, Humanized; D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; C015214:fibrinogen D fragment; D016572:Cyclosporine; D000077561:Daclizumab; D016559:Tacrolimus