The effects of tryptophan depletion on mood and psychiatric symptoms.
BACKGROUND
The number of studies using tryptophan depletion (TD) challenge has increased markedly in the past few years. Recently, a number of negative results have been published, implicating that the effect of TD on mood may be less consistent than previously thought.


METHODS
The literature on the mood effects of TD in psychiatric patients and healthy volunteers was reviewed.


RESULTS
TD has a mood-lowering effect in subgroups of recovered depressed patients, patients with seasonal affective disorder and vulnerable healthy subjects. The mood effect in former patients is of a different quality, however, than the effect in healthy subjects. Some recent negative studies in depression might be explained by insufficient lowering of plasma tryptophan levels. Preliminary evidence exists for an effect of TD on bulimia nervosa, autism, aggression and substance dependence.


CONCLUSIONS
The effects of TD on mood may be more consistent than suggested by a number of recent negative studies. Response to TD in recovered depressed patients is associated with prior treatment. However, even in SSRI-treated patients the relapse rates are not higher than 50-60%, which needs to be explained. The clinical usefulness of the response to TD in recovered patients (prediction of relapse after treatment discontinuation) and in symptomatic patients (prediction of treatment refractoriness) deserves more research attention. Further suggestions for future research include the cognitive effects of TD in recovered depressed patients and the effect of dietary habits on response to TD.
Van der Does
A J
AJ
Departments of Psychology and Psychiatry, Leiden University, Wassenaarseweg 52, 2333 AK, Leiden, The Netherlands. vanderdoes@fsw.leidenuniv.nl
D000856:Anorexia Nervosa / Q000378:metabolism* / Q000523:psychology; D001714:Bipolar Disorder / Q000378:metabolism / Q000523:psychology; D001921:Brain / Q000378:metabolism; D002032:Bulimia / Q000378:metabolism* / Q000523:psychology; D003072:Cognition Disorders / Q000209:etiology; D003865:Major Depressive Disorder / Q000378:metabolism / Q000523:psychology; D006801:Humans; D019964:Mood Disorders / Q000175:diagnosis / Q000378:metabolism* / Q000523:psychology; D009771:Obsessive-Compulsive Disorder / Q000378:metabolism* / Q000523:psychology; D012008:Recurrence; D012701:Serotonin / Q000378:metabolism; D012720:Severity of Illness Index; D019966:Substance-Related Disorders / Q000378:metabolism* / Q000523:psychology; D014364:Tryptophan / Q000172:deficiency*
D012701:Serotonin; D014364:Tryptophan