LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family.
Several LY294002-GM heterodimers were synthesized with the intent of modulating their activity in the presence of hsp90 and thereby creating selective inhibitors of PI3K and PI3K-related family.
Chiosis
G
G
Department of Molecular Oncogenesis, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA. chiosisg@mskmail.mskcc.org
Rosen
N
N
Sepp-Lorenzino
L
L
D064007:Ataxia Telangiectasia Mutated Proteins; D016227:Benzoquinones; D018797:Cell Cycle Proteins; D002867:Chromones / Q000737:chemistry / Q000494:pharmacology*; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D019281:Dimerization; D018841:HSP90 Heat-Shock Proteins / Q000737:chemistry / Q000378:metabolism; D020128:Inhibitory Concentration 50; D047029:Lactams, Macrocyclic; D009025:Morpholines / Q000737:chemistry / Q000494:pharmacology*; D000081082:Phosphoinositide-3 Kinase Inhibitors; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D011809:Quinones / Q000737:chemistry / Q000494:pharmacology*; D025521:Tumor Suppressor Proteins
D016227:Benzoquinones; D018797:Cell Cycle Proteins; D002867:Chromones; D004268:DNA-Binding Proteins; D018841:HSP90 Heat-Shock Proteins; D047029:Lactams, Macrocyclic; D009025:Morpholines; D000081082:Phosphoinositide-3 Kinase Inhibitors; D011809:Quinones; D025521:Tumor Suppressor Proteins; C085911:2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; D064007:Ataxia Telangiectasia Mutated Proteins; D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases; C001277:geldanamycin