Assessing vascular permeability during experimental cerebral malaria by a radiolabeled monoclonal antibody technique.
Vascular endothelial integrity, assessed by Evans blue dye extrusion and radiolabeled monoclonal antibody leakage, was markedly compromised in the brain, lung, kidney, and heart during Plasmodium berghei infection, a well-recognized model for human cerebral malaria. The results for vascular permeability from both methods were significantly (P < 0.001) related.
van der Heyde
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HC
Department of Microbiology and Immunology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA. hvande@lsuhsc.edu
Bauer
P
P
Sun
G
G
Chang
W L
WL
Yin
L
L
Fuseler
J
J
Granger
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DN
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002199:Capillary Permeability; D005070:Evans Blue / Q000378:metabolism; D005260:Female; D007371:Interferon-gamma / Q000502:physiology; D007457:Iodine Radioisotopes; D016779:Malaria, Cerebral / Q000503:physiopathology*; D051379:Mice; D008810:Mice, Inbred C57BL; D010962:Plasmodium berghei
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes; D005070:Evans Blue; D007371:Interferon-gamma