title: [Modifying effect of the repeated experience of agonistic confrontations on effect of naltrexone in male mice].
abstract: In mice with different experience of agonistic confrontations: victories or social defeats during 3 and 10 days (T3 and T10 winners and T3 and T10 losers, resp.), T10 winners displayed a lesser aggression and a more hostile behaviour than T3 winners. Naltrexone dose-dependently decreased attacks in the T3 winners and did not affect aggressive grooming, diggings, autogrooming, and exploratory activity. Naltrexone was ineffective in T10 winners. The naltrexone effects were similar in T3 and T10 losers and its high and low doses contrarily affected different parameters of submissive behaviour. The repeated experience of agonistic confrontations seems to modify the naltrexone effects depending on a neurochemical background, differing in winners and losers.
authors: Institute of Cytology and Genetics of the Russian Acad. Sci., Siberian Branch, Russia, 630090, Novosibirsk, Pr. Lavrentyeva, 10.
authors: N N
authors: NN
authors: Kudriavtseva
authors: V V
authors: VV
authors: Dolgov
authors: D F
authors: DF
authors: Avgustinovich
authors: O V
authors: OV
authors: Alekseenko
authors: T V
authors: TV
authors: Lipina
authors: L A
authors: LA
authors: Koriakina
mesh_terms: D000374:Aggression; D000818:Animals; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009271:Naltrexone / Q000494:pharmacology*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D012930:Social Dominance
chemical_list: D009292:Narcotic Antagonists; D009271:Naltrexone