The variance for the disequilibrium coefficient in the individual Hardy-Weinberg test.
It is of interest to detect the deviation from Hardy-Weinberg proportion (HWP) for a particular heterozygote. Hernández and Weir (1989, Biometrics 45, 53-70) suggested a disequilibrium coefficient approach and proposed a 1-d.f. chi2 test. This note derives the appropriate variance under the null hypothesis for performing this individual HWP test. Examples of applying the test to human genetic disease data are presented.
Chen
J J
JJ
Department of Integrative Biology, University of California at Berkeley, 94720-3140, USA. chenjj@slu.edu
Thomson
G
G
D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology; D001699:Biometry; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology; D005828:Genetics, Population; D005838:Genotype; D006684:HLA-DR Antigens / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical
D006684:HLA-DR Antigens