A variation of vitamin D deficiency in children.
We report three children presenting with hypocalcemia, hyperphosphatemia, elevated levels of parathyroid hormone, low concentrations of 25(OH)-vitamin D, normal to elevated concentrations of 1,25(OH)2-vitamin D, and normal radiographs. Although these findings led to consideration of parathyroid hormone resistance, clinical and biochemical findings remained normal after discontinuation of therapy, suggesting a variation of vitamin D deficiency.
Felner
E I
EI
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, USA. efelner@tulane.edu
Marks
J F
JF
Germak
J A
JA
D002118:Calcium / Q000627:therapeutic use; D002675:Child, Preschool; D005260:Female; D014644:Genetic Variation; D006801:Humans; D006996:Hypocalcemia / Q000150:complications / Q000188:drug therapy; D007223:Infant; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood; D014807:Vitamin D / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use; D014808:Vitamin D Deficiency / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*
D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D; C097949:1,25-dihydroxyvitamin D; C104450:25-hydroxyvitamin D; D002118:Calcium