Developmental changes in cerebrospinal fluid concentrations of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy.
Using a Coulochem electrode array system, we investigated the developmental changes of monoamine-related substances in patients with dentatorubral-pallidoluysian atrophy. The patterns observed in the developmental changes of tryptophan, tyrosine, homovanillic acid (HVA), 3-O-methyldopa, and 3-methoxy4-hydroxyphenyl glycol (MHPG) in patients with dentatorubral-pallidoluysian atrophy are quite different from those in control subjects. These abnormal developmental changes in monoamine-related substances may be implicated in age-related differences in clinical symptoms of dentatorubral-pallidoluysian atrophy.
Takeuchi
Y
Y
Department of Pediatrics, Kyoto Prefectural University of Medicine, Kawaramachi-Hirokoji, Japan. takeuchi@belle.shiga-med.ac.jp
Matsushita
H
H
Sakai
H
H
Kawano
H
H
Ochi
M
M
D000293:Adolescent; D000367:Age Factors; D000375:Aging / Q000134:cerebrospinal fluid*; D015306:Biogenic Monoamines / Q000378:metabolism*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid*; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000134:cerebrospinal fluid*; D020191:Myoclonic Epilepsies, Progressive / Q000134:cerebrospinal fluid* / Q000378:metabolism; D014364:Tryptophan / Q000134:cerebrospinal fluid*; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000134:cerebrospinal fluid*
D015306:Biogenic Monoamines; D014443:Tyrosine; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan; C008404:3-methoxytyrosine; D006719:Homovanillic Acid