Inhibitory effects of 6-O-acylated L-ascorbic acids possessing a straight- or branched-acyl chain on Epstein-Barr virus activation.
6-O-Acylated L-ascorbic acids possessing a straight- or branched-acyl chain of varying length from C(4) to C(18) have been synthesized and evaluated their anti-tumor promoting effects on the activation of the Epstein-Barr virus early antigen. The derivatives having a straight- or branched-acyl chain of C(6) to C(11) carbon atoms exhibited marked effects.
Uesato
S
S
Department of Biotechnology, Faculty of Engineering, Kansai University, Suita, 564-8680, Osaka, Japan. uesato@ipcku.kansai-u.ac.jp
Kitagawa
Y
Y
Kaijima
T
T
Tokuda
H
H
Okuda
M
M
Mou
X Y
XY
Mukainaka
T
T
Nishino
H
H
D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D000956:Antigens, Viral / Q000032:analysis; D000975:Antioxidants / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000502:physiology; D015394:Molecular Structure; D014775:Virus Activation / Q000187:drug effects
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D000975:Antioxidants; D001205:Ascorbic Acid