Angiogenesis and G-protein-coupled receptors: signals that bridge the gap.
Angiogenesis is a mechanism that has repercussions in a number of physiological and pathological situations. Vascular endothelial growth factor and basic fibroblast growth factor have understandably received enormous research coverage for being the major mediators of new blood vessel growth, often overshadowing other agonist that also have strong angiogenic potential. We wish to put the spotlight on GPCR agonists that undoubtedly have their word to say on the subject of angiogenesis. In this short review, we will discuss our findings along with the work from other groups on the mechanisms by which GPCR agonists, like thrombin and angiotensin II, control a number of angiogenic signals. A complete understanding of these mechanisms could, by the design of new therapeutic strategies, have a strong impact in clinical oncology.
Richard
D E
DE
Institute of Signaling, Developmental Biology and Cancer Research, UMR-CNRS 6543, Centre Antoine Lacassagne, 33 Avenue de Valombrose, 06189 Nice, France.
Vouret-Craviari
V
V
Pouysségur
J
J
D000809:Angiotensins / Q000494:pharmacology; D001808:Blood Vessels / Q000254:growth & development; D016228:Endothelial Growth Factors / Q000096:biosynthesis; D019204:GTP-Binding Proteins / Q000378:metabolism*; D008222:Lymphokines / Q000096:biosynthesis; D009389:Neovascularization, Pathologic; D018919:Neovascularization, Physiologic; D011956:Receptors, Cell Surface / Q000378:metabolism*; D015398:Signal Transduction; D013917:Thrombin / Q000494:pharmacology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D000809:Angiotensins; D016228:Endothelial Growth Factors; D008222:Lymphokines; D011956:Receptors, Cell Surface; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013917:Thrombin; D019204:GTP-Binding Proteins