Effect of nifedipine on proliferation and DNA synthesis of human gingival fibroblasts.
OBJECTIVE
To investigate the effect of Nifedipine, a calcium channel blocker, on cellular proliferation in gingival fibroblasts in vitro.


METHODS
Gingival fibroblasts were cultured and incubated with various concentrations of Nifedipine (23.5, 108, 360, and 1200 ng/mL) for up to 7 days.


RESULTS
Cell numbers were significantly different among these groups on the sixth and seventh days, especially between the 1200 ng/mL or 360 ng/mL and the other concentrations.


CONCLUSIONS
Nifedipine can influence proliferation of gingival fibroblasts in high concentrations.
Sun
W
W
Department of Periodontology, College of Stomatology, Nanjing Medical University (NMU), 136 Hanzhong Road, Nanjing 210029, P.R. China.
Jiang
C
C
Zheng
S
S
D000293:Adolescent; D000704:Analysis of Variance; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002648:Child; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects*; D005881:Gingiva / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D009543:Nifedipine / Q000008:administration & dosage / Q000494:pharmacology*; D019275:Radiopharmaceuticals; D013223:Statistics as Topic; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D002121:Calcium Channel Blockers; D019275:Radiopharmaceuticals; D014316:Tritium; D004247:DNA; D009543:Nifedipine; D013936:Thymidine