Klebsiella pneumoniae meningitis in thalassemia major patients.
Two thalassemia major patients received regular blood transfusion and desferrioxamine chelation, and 1 patient had a splenectomy at 9 years of age. Both patients developed Klebsiella pneumoniae meningitis at age of 27 and 15 years. They died within a short time despite appropriate antibiotic treatment. Klebsiella meningitis may be more common in transfusion-dependent thalassemia patients.
Li
C K
CK
Department of Pediatrics, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, China. ckli@cuhk.edu.hk
Shing
M M
MM
Chik
K W
KW
Lee
V
V
Yuen
P M
PM
D000293:Adolescent; D000328:Adult; D001803:Blood Transfusion; D002439:Cefotaxime / Q000627:therapeutic use; D002442:Ceftazidime / Q000627:therapeutic use; D002444:Cefuroxime / Q000627:therapeutic use; D002511:Cephalosporins / Q000627:therapeutic use*; D003676:Deferoxamine / Q000627:therapeutic use; D017809:Fatal Outcome; D006801:Humans; D007710:Klebsiella Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D007711:Klebsiella pneumoniae / Q000302:isolation & purification*; D008297:Male; D016920:Meningitis, Bacterial / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D013156:Splenectomy; D017086:beta-Thalassemia / Q000150:complications* / Q000628:therapy
D002511:Cephalosporins; D002442:Ceftazidime; D003676:Deferoxamine; D002439:Cefotaxime; D002444:Cefuroxime