[Reflux esophagitis--a community-wide increase in incidence].
Gastroesophageal reflux disease (GERD) is a common disease increasing in incidence and prevalence in the industrialised countries. It is a chronic disease with a large spectrum of clinical manifestations. The leading symptom is heartburn, however the disease may also present with extraesophageal symptoms or stay asymptomatic. Motility disorders of the upper GI tract with the key feature of impaired LES are the cause for pathologic gastroesophageal reflux in the terminal esophagus. The relationship of H. pylori infection with GERD is part of the current discussion. The Savary Miller classification for grading of refluxesophagitis is now proposed for substitution by the Los Angeles classification for the assessment of erosive lesions. Besides complications such as bleeding or strictures the main risk is the development of Barrett esophagus and adenocarcinoma. Proton pump inhibitors are the therapy of choice for healing as well as in longterm therapy and prophylaxis. New endoscopic interventional therapies for treatment of GERD and related diseases should be used only in controlled studies.
Gerards
C
C
Klinik für Gastroenterologie und Hepatologie, Otto-von-Guericke Universität Magdeburg, Leipziger Str. 44, 39120 Magdeburg, Deutschland.
Peitz
U
U
Malfertheiner
P
P
D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D003937:Diagnosis, Differential; D015154:Esophageal Motility Disorders / Q000150:complications; D004942:Esophagitis, Peptic / Q000145:classification* / Q000150:complications / Q000453:epidemiology* / Q000209:etiology / Q000628:therapy; D004945:Esophagoscopy; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000150:complications / Q000382:microbiology* / Q000503:physiopathology; D005858:Germany / Q000453:epidemiology; D016481:Helicobacter Infections / Q000150:complications* / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D015994:Incidence; D015995:Prevalence; D012720:Severity of Illness Index
D000897:Anti-Ulcer Agents