title: Unrelated umbilical cord stem cell transplantation for X-linked immunodeficiencies.
abstract: Banked unrelated umbilical cord blood matched at 5 of 6 human leukocyte antigen loci was used to reconstitute the immune system in 2 brothers with X-linked lymphoproliferative syndrome and 1 boy with X-linked hyperimmunoglobulin-M syndrome. Pretransplant cytoreduction and posttransplant graft-versus-host prophylaxis were given. Hematopoietic engraftment and correction of the genetic defects were documented by molecular techniques. Two years after transplantation, all 3 patients have normal immune systems. These reports support the wider use of banked partially matched cord blood for transplantation in primary immunodeficiencies.
authors: Division of Immunology/Allergy/Rheumatology, Mattel Children's Hospital at UCLA, Los Angeles, California 90095-1752, USA.
authors: U H
authors: UH
authors: Ziegner
authors: H D
authors: HD
authors: Ochs
authors: C
authors: C
authors: Schanen
authors: S A
authors: SA
authors: Feig
authors: K
authors: K
authors: Seyama
authors: T
authors: T
authors: Futatani
authors: T
authors: T
authors: Gross
authors: M
authors: M
authors: Wakim
authors: R L
authors: RL
authors: Roberts
authors: D J
authors: DJ
authors: Rawlings
authors: S
authors: S
authors: Dovat
authors: J K
authors: JK
authors: Fraser
authors: E R
authors: ER
authors: Stiehm
mesh_terms: D023201:CD40 Ligand / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004252:DNA Mutational Analysis / Q000379:methods; D005312:Fetal Blood / Q000166:cytology*; D006086:Graft vs Host Disease / Q000517:prevention & control; D018380:Hematopoietic Stem Cell Transplantation / Q000379:methods*; D006801:Humans; D007223:Infant; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology / Q000628:therapy*; D008297:Male; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D023201:CD40 Ligand