Ligands recognizing the minor groove of DNA: development and applications.
Polyamide ligands comprised of pyrrole, imidazole and hydroxypyrrole rings have been developed over the past decade which can be used to target many different, predetermined DNA sequences through recognition of functional groups in the minor groove. The design principles for these ligands are described with a description of the characterization of their binding. Variations containing linked recognition modules have been described which allow high affinity and specificity recognition of DNA sequences of over 15 base pairs. Recent applications of these ligands in affecting biological response through competition with proteins for DNA binding sites are reviewed.
Wemmer
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Department of Chemistry, University of California Berkeley and Physical Biosciences Division, Lawrence Berkeley National Lab, Berkeley, CA 94720, USA.
D000998:Antiviral Agents / Q000737:chemistry / Q000378:metabolism; D020029:Base Pairing; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004214:Distamycins / Q000737:chemistry / Q000378:metabolism; D008024:Ligands; D008958:Models, Molecular; D015394:Molecular Structure; D009429:Netropsin / Q000737:chemistry / Q000378:metabolism; D009690:Nucleic Acid Conformation
D000998:Antiviral Agents; D004214:Distamycins; D008024:Ligands; D009429:Netropsin; C030000:stallimycin; D004247:DNA