Discovery of a novel lead structure for anti-malarials.
From a library of 61 compounds available from former studies 2,5-bis-acylaminobenzophenone 7p was identified as a lead structure for a novel class of anti-malaria agents active against multi-resistant Plasmodium falciparum strain Dd2. Some structural modifications of this initial lead demonstrated the potential for further improvement of the anti-plasmodial activity of this novel class of anti-malarials.
Wiesner
J
J
Biochemisches Institut der Universitätsklinik Giessen, Germany.
Wissner
P
P
Dahse
H M
HM
Jomaa
H
H
Schlitzer
M
M
D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000494:pharmacology*; D001577:Benzophenones / Q000737:chemistry / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D020650:Combinatorial Chemistry Techniques; D018432:Drug Resistance, Multiple; D006801:Humans; D020128:Inhibitory Concentration 50; D010963:Plasmodium falciparum / Q000187:drug effects* / Q000254:growth & development; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000962:Antimalarials; D001577:Benzophenones