title: General behavior, toxicity, and cytotoxic activity of elenoside, a lignan from Justicia hyssopifolia.
abstract: Cytotoxicity, acute toxicity, and general pharmacological effects in mice of an arylnaphthalene lignan isolated from Jisticia hyssopifolia were studied. Elenoside was cytotoxic to human cancer cell lines in a range of concentrations from 10(-5) to 10(-4)M. It has an LD(50), ip in mice, of 305 mg/kg and central depressive properties at doses of 25, 50, and 100 mg/kg. Thus, elenoside appears to be a sedative with broad spectrum cytotoxicity.
authors: Department of Pharmacology, University of La Laguna, Tenerife, Spain.
authors: E
authors: E
authors: Navarro
authors: S J
authors: SJ
authors: Alonso
authors: J
authors: J
authors: Trujillo
authors: E
authors: E
authors: Jorge
authors: C
authors: C
authors: Pérez
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000633:toxicity; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007928:Lethal Dose 50; D017705:Lignans / Q000494:pharmacology* / Q000633:toxicity; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D051379:Mice; D014407:Tumor Cells, Cultured
chemical_list: D000928:Antidepressive Agents; D000972:Antineoplastic Agents, Phytogenic; D017705:Lignans; C428195:elenoside