Cancer.     A CINtillating new job for the APC tumor suppressor.
Pellman
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Department of Pediatric Oncology, Dana-Farber Cancer Institute, and Pediatric Hematology/Oncology, Children's Hospital, Harvard Medical School, 44 Binney Street, Boston, MA 02115, USA. david_pellman@dfci.harvard.edu
D025601:Adenomatous Polyposis Coli Protein; D000782:Aneuploidy; D000818:Animals; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D020090:Chromosome Segregation; D002875:Chromosomes / Q000502:physiology*; D003110:Colonic Neoplasms / Q000235:genetics* / Q000378:metabolism / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000737:chemistry / Q000378:metabolism*; D017491:Genes, APC; D006801:Humans; D018386:Kinetochores / Q000378:metabolism*; D051379:Mice; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008870:Microtubules / Q000378:metabolism*; D008938:Mitosis; D009154:Mutation; D011494:Protein Kinases / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases; D008941:Spindle Apparatus / Q000378:metabolism; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism; D015534:Trans-Activators; D051176:beta Catenin
D025601:Adenomatous Polyposis Coli Protein; C495270:CTNNB1 protein, human; C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; C405804:EB1 microtubule binding proteins; D008869:Microtubule-Associated Proteins; D015534:Trans-Activators; D051176:beta Catenin; D011494:Protein Kinases; C090464:Bub1 spindle checkpoint protein; D017346:Protein Serine-Threonine Kinases