title: Novel sulfonate analogues of combretastatin A-4: potent antimitotic agents.
abstract: Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
authors: Cancer Research, Abbott Laboratories, Abbott Park, IL 60064-6101, USA. stephen.gwaltney@abbott.com
authors: S L
authors: SL
authors: Gwaltney
authors: H M
authors: HM
authors: Imade
authors: K J
authors: KJ
authors: Barr
authors: Q
authors: Q
authors: Li
authors: L
authors: L
authors: Gehrke
authors: R B
authors: RB
authors: Credo
authors: R B
authors: RB
authors: Warner
authors: J Y
authors: JY
authors: Lee
authors: P
authors: P
authors: Kovar
authors: J
authors: J
authors: Wang
authors: M A
authors: MA
authors: Nukkala
authors: N A
authors: NA
authors: Zielinski
authors: D
authors: D
authors: Frost
authors: S C
authors: SC
authors: Ng
authors: H L
authors: HL
authors: Sham
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis / Q000235:genetics; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D001665:Binding Sites / Q000502:physiology; D001667:Binding, Competitive; D002455:Cell Division / Q000187:drug effects; D003078:Colchicine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D006801:Humans; D011108:Polymers / Q000378:metabolism; D013267:Stilbenes / Q000737:chemistry* / Q000494:pharmacology*; D014404:Tubulin / Q000378:metabolism; D050257:Tubulin Modulators; D014407:Tumor Cells, Cultured / Q000166:cytology / Q000187:drug effects
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D011108:Polymers; D013267:Stilbenes; D014404:Tubulin; D050257:Tubulin Modulators; C058728:fosbretabulin; D003078:Colchicine