Inhibitory effects of sophoraflavanones B and H in Sophora mooracroftiana Beth ex Baker on copper-ion-induced protein oxidative modification of mice brain homogenate in vitro.
We present the results of an in vitro investigation of the inhibitory effects of sophoraflavanones B and H isolated from Sophora mooracroftiana Beth ex Baker on copper-induced protein oxidative modification. They inhibited copper-induced protein oxidative modification. Their effects were stronger than those of naringenin as a related flavanone, and of mannitol as a hydroxyl radical scavenger. The results suggest that these natural products may be of use in cases where oxidative stress is present.
Toda
S
S
Department of Pharmaceutical Science, Kansai College of Oriental Medicine, Osaka, Japan.
Shirataki
Y
Y
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D003300:Copper / Q000494:pharmacology; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D010084:Oxidation-Reduction; D010944:Plants / Q000737:chemistry; D011506:Proteins / Q000378:metabolism*; D014020:Tissue Extracts
D000975:Antioxidants; D044950:Flavanones; D005419:Flavonoids; D011506:Proteins; D014020:Tissue Extracts; C433506:sophoraflavonone B; C433507:sophoraflavonone H; D008353:Mannitol; D003300:Copper; C005273:naringenin