title: Platelet satellitism as presenting finding in mantle cell lymphoma. A case report.
abstract: Platelet satellitism surrounding polymorphonuclear neutrophils has been observed almost exclusively in EDTA-treated blood at room temperature. The mechanism underlying this phenomenon is not understood fully. We report a case of platelet rosetting around atypical lymphocytes in peripheral blood smears made from EDTA-treated and untreated blood. Flow cytometry of the peripheral blood sample and immunohistochemical stains of the subsequent bone marrow biopsy specimen revealed a monoclonal B-cell population positive for CD5, CD20, and cyclin D1 and negative for CD3 and CD23; cytogenetic findings revealed a complex karyotype that included t(11;14). These findings were consistent with mantle cell lymphoma. To our knowledge, the finding of platelet satellitism involving mantle cell lymphoma cells in peripheral blood has not been reported previously.
authors: Department of Pathology, Medical College of Virginia Hospitals of Virginia Commonwealth University, Richmond, USA.
authors: C
authors: C
authors: Cesca
authors: J
authors: J
authors: Ben-Ezra
authors: R S
authors: RS
authors: Riley
mesh_terms: D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D001402:B-Lymphocytes / Q000737:chemistry; D001792:Blood Platelets / Q000276:immunology / Q000473:pathology*; D017252:CD3 Complex / Q000032:analysis; D018956:CD5 Antigens / Q000032:analysis; D002469:Cell Separation; D019938:Cyclin D1 / Q000032:analysis; D004492:Edetic Acid; D005434:Flow Cytometry; D006801:Humans; D007124:Immunoenzyme Techniques; D007621:Karyotyping; D020522:Lymphoma, Mantle-Cell / Q000276:immunology / Q000473:pathology*; D008297:Male; D017455:Receptors, IgE / Q000032:analysis; D012397:Rosette Formation
chemical_list: D018951:Antigens, CD20; D017252:CD3 Complex; D018956:CD5 Antigens; D017455:Receptors, IgE; D019938:Cyclin D1; D004492:Edetic Acid