Outcome in critically ill patients with candidal fungaemia: Candida albicans vs. Candida glabrata.
In a retrospective study (1 January 1992-12 December 1998), we investigated population characteristics and outcome in critically ill patients with fungaemia involving C. albicans (n=41) and C. glabrata (n=15). Patients with C. glabrata fungaemia were significantly older compared with patients in the C. albicans group (P=0.024). There were no other differences in population characteristics or severity of illness. Logistic regression analysis showed age (P=0.021), the presence of a polymicrobial blood stream infection (P=0.039), and renal failure (P=0.044) to be independent predictors of mortality. There was no significant difference in in-hospital mortality between the C. glabrata and C. albicans groups (60.0% vs. 41.5%; P=0.24). Since age was an independent predictor of mortality, the trend towards a higher mortality in patients with C. glabrata can be explained by this population being significantly older. In conclusion, we found no difference in mortality between patients with fungaemia involving C. albicans and C. glabrata.
Blot
S
S
Department of Intensive Care, Ghent University Hospital, Ghent, Belgium. icu@rug.ac.be
Vandewoude
K
K
Hoste
E
E
Poelaert
J
J
Colardyn
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000935:Antifungal Agents / Q000627:therapeutic use; D002175:Candida / Q000302:isolation & purification*; D002176:Candida albicans; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality*; D016638:Critical Illness; D003428:Cross Infection / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality*; D016469:Fungemia / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality*; D017052:Hospital Mortality; D006801:Humans; D007362:Intensive Care Units; D016015:Logistic Models; D008875:Middle Aged; D012189:Retrospective Studies
D000935:Antifungal Agents