title: [P-wave signal averaging-ECG: normal values and reproducibility].
abstract: Signal averaging techniques are used for detection of low amplitude, high frequency signals in the surface ECG. P-wave signal-averaging has been used to predict the risk for development of atrial tachyarrhythmias in patients with structural heart disease. There is, however, a lack of prospective studies evaluating normal values of the P-wave signal-averaged ECG in healthy individuals. Moreover, day-to-day reproducibility of results of P-wave signal-averaging is not precisely known. Thus, the aim of this study was to determine normal values and reproducibility of time-domain P-wave signal-averaging in a large cohort of healthy volunteers. A commercially available device (MAC 5000, Marquette Hellige) was used for signal-averaging. A vector magnitude was calculated from Frank's orthogonal leads after P-waves were sampled and filtered with a spectral filter using fast fourier transform. We examined 123 volunteers without cardiovascular disease at two occasions. Mean P-wave duration was 114 +/- 13 ms for the overall study population. There was a slight but statistically significant increase in filtered P-wave duration with age (r = 0.32, p < 0.001). All values were reliably reproducible upon the second examination (r = 0.624 to 0.706, p < 0.0001). These results may serve as a future reference to other studies examining patients with structural heart disease.
authors: J. W.-Goethe-Universität, Frankfurt Medizinische Klinik IV Abteilung für Kardiologie Theodor-Stern-Kai 7 60599 Frankfurt/Main, Germany.
authors: J R
authors: JR
authors: Ehrlich
authors: G Q
authors: GQ
authors: Zhang
authors: C W
authors: CW
authors: Israel
authors: S H
authors: SH
authors: Hohnloser
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis* / Q000503:physiopathology; D004562:Electrocardiography / Q000295:instrumentation / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results; D012737:Sex Factors