The library of p-nitrophenyl esters of oligopeptides as a model to study the anticancer drug-peptide conjugates activated during tumor angiogenesis.
An indexed library of oligopeptide p-nitrophenyl esters immobilized via methoxy-1,3,5-triazine scaffold on the cellulose support, was synthesized by the step by step procedure and by segment coupling, involving 2-chloro-4,6-dimethoxy-1,3,5-triazine as a condensing reagent. The substrate specificity towards homogenate supernatant of mouse lung cancer LL2 cells has been studied.
Kinas
R W
RW
Department of Bioorganic Chemistry, Center of Molecular and Macromolecular Studies, PAS, Łodź.
Opolski
A
A
Kolesińska
B
B
Kamiński
Z J
ZJ
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D001711:Biotransformation; D020650:Combinatorial Chemistry Techniques; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D009389:Neovascularization, Pathologic / Q000378:metabolism*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D019151:Peptide Library; D014227:Triazines / Q000138:chemical synthesis / Q000493:pharmacokinetics
D000970:Antineoplastic Agents; D009842:Oligopeptides; D019151:Peptide Library; D014227:Triazines