title: Real-time visualization of high-intensity focused ultrasound treatment using ultrasound imaging.
abstract: High-intensity focused ultrasound (HIFU) and conventional B-mode ultrasound (US) imaging were synchronized to develop a system for real-time visualization of HIFU treatment. The system was tested in vivo in pig liver. The HIFU application resulted in the appearance of a hyperechoic spot at the focus that faded gradually after cessation of HIFU exposure. The duration of HIFU exposure needed for a hyperechoic spot to appear, was inversely related to the HIFU intensity. The threshold intensity required to produce a hyperechoic spot in liver in < 1 s was 970 W/cm(2), in situ. At this HIFU dose, no immediate cellular damage was observed, providing a potential for pretreatment targeting. The real-time visualization method was used in hemostasis of actively bleeding internal pelvic vessels, allowing targeting and monitoring of successful treatment. Real-time US imaging may provide a useful tool for image-guided HIFU therapy.
authors: Department of Bioengineering, University of Washington, Seattle, WA 98195, USA. adasi@u.washington.edu
authors: S
authors: S
authors: Vaezy
authors: X
authors: X
authors: Shi
authors: R W
authors: RW
authors: Martin
authors: E
authors: E
authors: Chi
authors: P I
authors: PI
authors: Nelson
authors: M R
authors: MR
authors: Bailey
authors: L A
authors: LA
authors: Crum
mesh_terms: D000818:Animals; D004867:Equipment Design; D008099:Liver / Q000000981:diagnostic imaging; D013552:Swine; D014464:Ultrasonic Therapy; D014463:Ultrasonography / Q000379:methods*