title: Amygdala and hippocampal volumes in children with Down syndrome: a high-resolution MRI study.
abstract: The objective of this study was to use high-resolution MRI techniques to determine whether children with Down syndrome exhibit decreases in hippocampal and amygdala volumes similar to those demonstrated in recent studies of adults with this condition. When corrected for overall brain volumes, amygdala volumes did not differ between groups but hippocampal volumes were significantly smaller in the Down syndrome group. These findings suggest that the hippocampal volume reduction seen in adults with Down syndrome may be primarily due to early developmental differences rather than neurodegenerative changes.
authors: Department of Neurology, University of Washington School of Medicine, Seattle, USA. pinter@u.washington.edu
authors: J D
authors: JD
authors: Pinter
authors: W E
authors: WE
authors: Brown
authors: S
authors: S
authors: Eliez
authors: J E
authors: JE
authors: Schmitt
authors: G T
authors: GT
authors: Capone
authors: A L
authors: AL
authors: Reiss
mesh_terms: D000679:Amygdala / Q000473:pathology*; D002648:Child; D004314:Down Syndrome / Q000473:pathology*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male