Renal failure and vestibular toxicity in an adolescent with cystic fibrosis receiving gentamicin and standard-dose ibuprofen.
Gentamicin and standard-dose ibuprofen were administered to an adolescent with cystic fibrosis who developed renal failure and severe vestibulotoxicity. A contributing factor was possible suboptimal intravascular volume status. Because of the potential severity of this drug interaction, hydration status and renal and vestibular functions should be closely monitored in patients receiving ibuprofen and intravenous aminoglycosides concomitantly.
Scott
C S
CS
Division of Pharmacotherapy, School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-7360, USA. christy_scott@unc.edu
Retsch-Bogart
G Z
GZ
Henry
M M
MM
D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D003550:Cystic Fibrosis / Q000188:drug therapy*; D005839:Gentamicins / Q000009:adverse effects*; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects*; D008297:Male; D051437:Renal Insufficiency / Q000139:chemically induced*; D015837:Vestibular Diseases / Q000139:chemically induced*; D014882:Water-Electrolyte Balance
D000900:Anti-Bacterial Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D005839:Gentamicins; D007052:Ibuprofen