Sequence and antigenic variability of the Helicobacter mustelae surface ring protein Hsr.
We have identified an array of more than 500 repetitive sequences flanking the hsr gene, which encodes the major surface protein of the ferret pathogen Helicobacter mustelae. The repeats show identity exclusively to the amino-terminal half of Hsr. Analysis of Hsr from three strains indicated variability of exposed epitopes. Characterization of an hsr mutant showed that Hsr is not an adhesin.
Forester
N
N
Institute of Molecular BioSciences, Massey University, Palmerston North, New Zealand.
Lumsden
J S
JS
O'Croinin
T
T
O'Toole
P W
PW
D000595:Amino Acid Sequence; D000818:Animals; D001422:Bacterial Adhesion; D001426:Bacterial Proteins / Q000737:chemistry* / Q000276:immunology / Q000502:physiology; D005289:Ferrets / Q000382:microbiology*; D016998:Helicobacter / Q000737:chemistry* / Q000276:immunology; D008969:Molecular Sequence Data; D011817:Rabbits; D020449:Repetitive Sequences, Amino Acid
D001426:Bacterial Proteins