New single-isomer chiral selector for capillary electrophoresis: the highly water-soluble heptakis(2-N,N-dimethylcarbamoyl)-beta-cyclodextrin.
A new single isomer beta-cyclodextrin, the heptakis(2-N,N-dimethylcarbamoyl)-beta-cyclodextrin (HDMC-beta-CD), has been synthesized and spectroscopically characterized. The outstanding feature of the new neutral beta-CD derivatives is their high solubility in water (>100 mM) and methanol. The resolution of chiral drugs can take advantage of this property. The resolution power of the new HDMC-beta-CD is demonstrated by a selection of acidic and basic compounds using standard conditions.
Christians
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T
Institute of Pharmacy, University of Bonn, Germany.
Holzgrabe
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D003505:Cyclodextrins / Q000737:chemistry*; D019075:Electrophoresis, Capillary / Q000379:methods*; D007202:Indicators and Reagents / Q000737:chemistry*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D012995:Solubility; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013237:Stereoisomerism; D047392:beta-Cyclodextrins
D003505:Cyclodextrins; D007202:Indicators and Reagents; D047392:beta-Cyclodextrins; C434545:heptakis(2-N,N-dimethylcarbamoyl)-beta-cyclodextrin