title: Histamine upregulates Th1 and downregulates Th2 responses due to different patterns of surface histamine 1 and 2 receptor expression.
abstract: Histamine, which acts via G protein-coupled receptors, is an important mediator of immediate hypersensitivity and is also able to influence the nature of T cell responses. We demonstrated that TH1 and Th2 cells express distinct surface histamine receptor patterns and that Th1-type responses are enhanced by histamine, whereas Th2-type responses are negatively regulated, due to different intracellular signals generated by histamine stimulation. These findings account for negative feedback regulation in a wide variety of pathologies.
authors: Wroclaw University of Medicine, Wroclaw, Poland. mjutel@dilnet.wroc.pl
authors: M
authors: M
authors: Jutel
authors: S
authors: S
authors: Klunker
authors: M
authors: M
authors: Akdis
authors: J
authors: J
authors: Małolepszy
authors: O A
authors: OA
authors: Thomet
authors: T
authors: T
authors: Zak-Nejmark
authors: K
authors: K
authors: Blaser
authors: C A
authors: CA
authors: Akdis
mesh_terms: D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis; D015536:Down-Regulation; D006632:Histamine / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation; D018448:Models, Immunological; D012333:RNA, Messenger / Q000096:biosynthesis; D011969:Receptors, Histamine H1 / Q000096:biosynthesis* / Q000235:genetics; D011970:Receptors, Histamine H2 / Q000096:biosynthesis* / Q000235:genetics; D015398:Signal Transduction; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D014158:Transcription, Genetic; D015854:Up-Regulation
chemical_list: D016207:Cytokines; D012333:RNA, Messenger; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D006632:Histamine