Effect of process parameters upon the dopamine and lipid peroxidation activity of selected MIG welding fumes as a marker of potential neurotoxicity.
There is growing concern over the neurotoxic effects of chronic occupational exposure to metal fume produced by welding. Elevated iron and manganese levels in the brain have been linked to an increase in lipid peroxidation, dopamine depletion and predisposition to the development of a Parkinson's type condition in advanced cases. Chemical and toxicological analysis of selected welding fumes, generated by model processes, were used in order to evaluate their potential to release solutes that promote oxidation of dopamine and peroxidation of brain lipids in cell free assays. This study compared the effect of shield gas, electrode type and voltage/currect upon the dopamine and brain lipid peroxidation potential of selected welding fume, obtained from metal inert gas (MIG) welding systems. Overall, fume extracts were found to enhance dopamine oxidation and inhibit lipid peroxidation. Significant differences were also found in the oxidising potential of fume generated under differing process conditions; it may therefore be possible to determine the potential neurotoxicity of fumes using this system.
Hudson
N J
NJ
Dept of Environmental Science, University of Bradford, BD7 1DP, Bradford, UK.
Evans
A T
AT
Yeung
C K
CK
Hewitt
P J
PJ
D000818:Animals; D015415:Biomarkers; D001921:Brain / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D020260:Heavy Metal Poisoning, Nervous System / Q000378:metabolism*; D066298:In Vitro Techniques; D015227:Lipid Peroxidation; D051379:Mice; D005741:Noble Gases / Q000032:analysis / Q000493:pharmacokinetics*; D014896:Welding
D015415:Biomarkers; D005741:Noble Gases; D004298:Dopamine