title: Carboxypeptidase U at the interface between coagulation and fibrinolysis.
abstract: In 1988, Hendricks et al. first reported on the presence of carboxypeptidase U (U refers to the unstable nature of the enzyme) in human serum. One decade later, the importance of carboxypeptidase U (CPU) in the regulation of fibrin clot dissolution is well documented. CPU circulates in plasma as an inactive zymogen, proCPU, that is converted to its active form during coagulation and fibrinolysis. CPU cleaves off C-terminal lysine residues exposed on fibrin partially degraded by the action of plasmin. Because these C-terminal lysine residues are important for upregulating the fibrinolytic rate, CPU thus slows down fibrinolysis.
authors: Laboratory of Medical Biochemistry, University of Antwerp, Belgium.
authors: K
authors: K
authors: Schatteman
authors: F
authors: F
authors: Goossens
authors: J
authors: J
authors: Leurs
authors: R
authors: R
authors: Verkerk
authors: S
authors: S
authors: Scharpé
authors: J J
authors: JJ
authors: Michiels
authors: D
authors: D
authors: Hendriks
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D025901:Carboxypeptidase B2; D002268:Carboxypeptidases / Q000097:blood* / Q000502:physiology; D005342:Fibrinolysis / Q000187:drug effects*; D006487:Hemostasis / Q000187:drug effects; D006801:Humans
chemical_list: D002268:Carboxypeptidases; D025901:Carboxypeptidase B2