Simulation of enzymatic cellular reactions complicated by phase separation.
We present two-dimensional Monte Carlo simulations of enzymatic cellular reaction occurring via the Michaelis-Menten scheme in the case of attractive interactions between the reaction products. The model employed predicts phase separation in the cell provided that the reaction is relatively fast. The shape of the corresponding patterns varies from a few separate islands to a large patch located in the center of the cell. The fluctuations of the reaction rate during such regimes are found to be much higher than those predicted by the Poissonian distribution.
Zhdanov
V P
VP
Department of Applied Physics, Chalmers University of Technology, 412 96 Göteborg, Sweden. zhdanov@catalysis.nsk.su
D000465:Algorithms; D001703:Biophysics / Q000379:methods; D002477:Cells / Q000201:enzymology*; D004798:Enzymes / Q000737:chemistry*; D007700:Kinetics; D008954:Models, Biological; D013997:Time Factors
D004798:Enzymes