title: Perioperative factors as predictors of operative mortality and morbidity in pneumonectomy.
abstract: Pneumonectomy for lung cancer is associated with significant morbidity and mortality. Risk factors for the morbidity and mortality have been reported, but consistent conclusive data are undetermined. Current accepted 30-day mortality rates for pneumonectomy range from 7 to 11 per cent. The objective of this study is to determine whether various perioperative factors can serve as predictors of morbidity and mortality in pneumonectomy patients and to review outcome data on patients undergoing pneumonectomy for lung cancer. A total of 105 patients undergoing pneumonectomy for lung cancer from 1988 through 1998 are studied in a retrospective chart review. The main outcome measure is the 30-day operative mortality and morbidity. Complications occurring in 10 per cent or more of the patients included atrial fibrillation (33.3%), respiratory failure (23.8%), pneumonia (21.9%), and bronchopleural fistula (12.4%). The 30-day mortality rate was 10.5 per cent (11 deaths). By Fisher's exact test for Chi-square only three statistically significant mortality factors were identified: respiratory failure (P < 0.021), sepsis (P < 0.008), and male sex (P < 0.031); respiratory failure, sepsis, and sex were predictors of death. Significant correlation could not be made to predict postoperative morbidity. Overall long-term clinical outcome for pneumonectomy as lung cancer treatment was poor. Clinical judgment remains an essential factor when considering pneumonectomy as an option for lung cancer treatment.
authors: Department of Surgery, University of Illinois College of Medicine-Peoria, Illinois 61603, USA.
authors: J B
authors: JB
authors: Joo
authors: J R
authors: JR
authors: DeBord
authors: C E
authors: CE
authors: Montgomery
authors: J R
authors: JR
authors: Munns
authors: J S
authors: JS
authors: Marshall
authors: J K
authors: JK
authors: Paulsen
authors: R C
authors: RC
authors: Anderson
authors: L E
authors: LE
authors: Meyer
authors: N C
authors: NC
authors: Estes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000150:complications; D001983:Bronchial Fistula / Q000150:complications; D016009:Chi-Square Distribution; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D011013:Pneumonectomy / Q000009:adverse effects* / Q000401:mortality*; D011014:Pneumonia / Q000150:complications; D011237:Predictive Value of Tests; D011379:Prognosis; D012131:Respiratory Insufficiency / Q000150:complications; D012189:Retrospective Studies; D012307:Risk Factors; D018805:Sepsis / Q000150:complications; D017678:Sex Distribution; D016019:Survival Analysis; D016896:Treatment Outcome