Estrogen increases G protein coupled receptor kinase 2 in the cortex of female rats.
Treatment of ovariectomized female rats with estrogen for 2 days reduces alpha2-adrenoceptor binding density by 25%, increases G protein coupled receptor kinase (GRK) activity by 50% and elevates GRK 2 protein levels by 50% in the frontal cortex. These results suggest that estrogen may decrease alpha2-adrenoceptor expression in the frontal cortex of female rats by regulating GRK 2.
Ansonoff
M A
MA
Department of Neuroscience, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. ansonoff@cabm.rutgers.edu
Etgen
A M
AM
D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects* / Q000378:metabolism*; D054769:G-Protein-Coupled Receptor Kinase 2; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D051552:beta-Adrenergic Receptor Kinases
D004958:Estradiol; D017868:Cyclic AMP-Dependent Protein Kinases; C496569:Grk2 protein, rat; D051552:beta-Adrenergic Receptor Kinases; D054769:G-Protein-Coupled Receptor Kinase 2