Stereoselective reduction with NADH model BNAH through chiral induction in cyclodextrins.
Stereoselective reductive debromination-cyclopropanation of 2-bromo-1-phenylethylidene-malononitrile and 2-bromo-1-beta-naphthylethylidenemalononitrile by coenzyme NADH model BNAH through chiral induction in cyclodextrins is reported. The matching between substrates and cyclodextrins, the substituent effect, and the effect of cyclodextrin concentration on the optical yields have been investigated.
Liu
Y C
YC
Department of Chemistry, University of Science and Technology of China, Hefei, 230026, People's Republic of China. ycliu@ustc.edu.cn
Li
X Z
XZ
Yang
C
C
Guo
Q X
QX
D003505:Cyclodextrins / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D009243:NAD / Q000031:analogs & derivatives / Q000378:metabolism*; D010084:Oxidation-Reduction; D013237:Stereoisomerism
C445701:1-benzyl-1,4-dihydronicotinamide; D003505:Cyclodextrins; D009243:NAD