title: Effect of pneumoperitoneal pressure on tumor dissemination and tumor recurrence at port-site and midline incisions.
abstract: Over the past several years numerous cases of port site tumor recurrence after laparoscopic resection of a cancerous tissue have been reported. Possible mechanisms for tumor seeding include tumor removal, contaminated instruments, pneumoperitoneum, and aerosolization of tumor cells. This experiment examined the relationship among trocar contamination, aerosolization, and tumor recurrence with increasing pneumoperitoneal pressure using a hamster model. Increased pneumoperitoneal pressure significantly increased both instrument contamination and tumor recurrence at midline and port site incisions. Interestingly, increasing pneumoperitoneal pressure had no significant effect on the number of aerosolized tumor cells. The results reaffirm that the use of a reduced pneumoperitoneum or gasless laparoscopy may significantly lower port site tumor recurrence.
authors: Department of Colorectal Surgery, Cleveland Clinic Florida, Ft. Lauderdale 33309, USA.
authors: H
authors: H
authors: Moreira
authors: T
authors: T
authors: Yamaguchi
authors: S
authors: S
authors: Wexner
authors: L
authors: L
authors: Singer
authors: R
authors: R
authors: Zhao
authors: M K
authors: MK
authors: Baig
authors: J A
authors: JA
authors: Mack
authors: H
authors: H
authors: Xiong
authors: S
authors: S
authors: Abramson
mesh_terms: D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D004866:Equipment Contamination / Q000517:prevention & control; D010535:Laparoscopy / Q000009:adverse effects* / Q000379:methods*; D008647:Mesocricetus; D009364:Neoplasm Recurrence, Local / Q000209:etiology* / Q000473:pathology / Q000517:prevention & control; D009366:Neoplasm Seeding; D011028:Pneumoperitoneum, Artificial / Q000009:adverse effects* / Q000379:methods*; D011312:Pressure / Q000009:adverse effects