title: Multicenter experience with the thoratec ventricular assist device in children and adolescents.
abstract: BACKGROUND
  Patient size is 1 determinant in selecting a mechanical circulatory support device. The current pulsatile ventricular assist devices (VADs) were designed primarily for average-sized adults. The flexibility of the Thoratec VAD, however, has encouraged physicians to use it in a significant number of intermediate-sized older children and adolescents.
  
  
  METHODS
  We conducted a retrospective study in 58 children and adolescents <18 years (41 boys, 17 girls) who had been supported with the Thoratec VAD in 27 centers worldwide as of December 1999. Mean patient age was 13.8 years (range, 7 to 17 years), and mean patient weight and body surface area were 51.6 kg (range, 17 to 93 kg) and 1.5 m(2) (range, 0.7 to 2.1 m(2)), respectively.
  
  
  RESULTS
  Thirty-five patients (60%) survived to transplantation and 6 (10%) to recovery of the native heart, respectively; 38 were discharged from the hospital (66%). In the transplanted group, post-transplantation survival was 97%. Patient age and size were not associated with significantly increased risk for death or adverse events. Fifteen patients (27%) had 18 neurologic events during support, and 6 of these were fatal. Left atrial cannulation proved a risk factor for neurologic complications.
  
  
  CONCLUSIONS
  The Thoratec VAD has successfully been used in a large number of children and adolescents with similar morbidity and mortality results as with adults. The risk of neurologic complications may be increased, particularly in patients cannulated in the left atria.
authors: University of California at San Francisco Medical Center, San Francisco, California, USA.
authors: O
authors: O
authors: Reinhartz
authors: F M
authors: FM
authors: Keith
authors: A
authors: A
authors: El-Banayosy
authors: L R
authors: LR
authors: McBride
authors: R C
authors: RC
authors: Robbins
authors: J G
authors: JG
authors: Copeland
authors: D J
authors: DJ
authors: Farrar
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006331:Heart Diseases / Q000235:genetics / Q000401:mortality* / Q000628:therapy; D006353:Heart-Assist Devices / Q000009:adverse effects / Q000706:statistics & numerical data*; D006801:Humans; D008297:Male; D015999:Multivariate Analysis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D011795:Surveys and Questionnaires