[Elevated level of TGF-alpha in the mucosa of small intestine of the rat following massive small bowel resection].
This study was performed to determine the changes in TGF-alpha production during compensatory regeneration of small intestine. For this purpose rats underwent either 70% small bowel resection or sham operation. Levels of TGF-alpha production were evaluated by radioreceptor assay and Western blotting. When compared with sham operation, small bowel resection resulted in threefold increase in the production of TGF-alpha at postoperative day 3. Possible mechanisms of TGF-alpha involvement in intestinal adaptation following massive small bowel resection are discussed.
Fil'chenkov
O O
OO
R. E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology, National Academy of Science of Ukraine, Kiev.
D000222:Adaptation, Physiological; D000818:Animals; D015153:Blotting, Western; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism / Q000502:physiology*; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D012038:Regeneration; D016211:Transforming Growth Factor alpha / Q000378:metabolism*
D016211:Transforming Growth Factor alpha