title: The -238 tumor necrosis factor-alpha promoter polymorphism is associated with decreased susceptibility to cancers.
abstract: We investigated the potential association of tumor necrosis factor-alpha (TNF-alpha) promoter polymorphisms with cancers. The study included 169 patients with gastric cancer, uterine cervical cancer, colorectal cancer, or renal cell carcinoma and 92 healthy controls. The -308 and -238 polymorphisms in the TNF-alpha promoter were analyzed by PCR-restriction fragment length polymorphism (RFLP). The proportion of individuals carrying the TNF-238A allele was significantly lower in the cancer group than in the control group. The odds ratio for cancer in subjects with the TNF-238A allele was 0.25 (95% CI, 0.10-0.64). No association was found between the -308 polymorphism and cancers. These results suggest that the -238A allele has a protective function against cancers.
authors: The Paik-Inje Memorial Institute for Biomedical Science, Inje University, 614-735, Pusan, South Korea.
authors: W H
authors: WH
authors: Jang
authors: Y I
authors: YI
authors: Yang
authors: S S
authors: SS
authors: Yea
authors: Y J
authors: YJ
authors: Lee
authors: J H
authors: JH
authors: Chun
authors: H I
authors: HI
authors: Kim
authors: M S
authors: MS
authors: Kim
authors: K H
authors: KH
authors: Paik
mesh_terms: D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D009369:Neoplasms / Q000235:genetics*; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
chemical_list: D014409:Tumor Necrosis Factor-alpha