Patient-controlled analgesia and postoperative nausea and vomiting: efficacy of a continuous infusion of ondansetron.
A continuous infusion of ondansetron was compared with a placebo infusion in 80 patients undergoing major breast reconstructive surgery. All patients received a standard anaesthetic and a bolus dose of ondansetron after induction. They were then randomly allocated to receive an intravenous infusion of ondansetron or a placebo infusion for 24 h in a double-blind fashion. Postoperative analgesia was provided by patient-controlled subcutaneous diamorphine. In the ondansetron group, the severity of nausea, measured by a 10-point verbal rating scale, was reduced (p = 0.01) and fewer patients stated at postoperative interview that nausea and vomiting was a problem (p = 0.01).
White
L A
LA
Pain Relief Service, Salisbury District Hospital, Salisbury, Wiltshire SP2 8BJ, UK.
Vanarase
M
M
Brockbank
K
K
Barrett
R F
RF
D000293:Adolescent; D000328:Adult; D000368:Aged; D016058:Analgesia, Patient-Controlled / Q000009:adverse effects*; D000701:Analgesics, Opioid / Q000009:adverse effects; D000932:Antiemetics / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D003932:Heroin / Q000009:adverse effects; D006801:Humans; D007262:Infusions, Intravenous; D016462:Mammaplasty; D008875:Middle Aged; D017294:Ondansetron / Q000008:administration & dosage* / Q000627:therapeutic use; D017060:Patient Satisfaction; D020250:Postoperative Nausea and Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D000701:Analgesics, Opioid; D000932:Antiemetics; D017294:Ondansetron; D003932:Heroin