title: Interpreting PET and fMRI measures of functional neural activity: the effects of synaptic inhibition on cortical activation in human imaging studies.
abstract: Human brain imaging methods such as postiron emission tomography and functional magnetic resonance imaging have recently achieved widespread use in the study of both normal cognitive processes and neurological disorders. While many of these studies have begun to yield important insights into human brain function, the relationship between these measurements and the underlying neuronal activity is still not well understood. One open question is how neuronal inhibition is reflected in these imaging results. In this paper, we describe how large-scale modeling can be used to address this question. Specifically, we identify three factors that may play a role in how inhibition affects imaging results: (1) local connectivity; (2) context; and (3) type of inhibitory connection. Simulation results are presented that show how the interaction among these three factors can explain seemingly contradictory experimental results. The modeling suggests that neuronal inhibition can raise brain imaging measures if there is either low local excitatory recurrence or if the region is not otherwise being driven by excitation. Conversely, with high recurrence or actively driven excitation, inhibition can lower observed values.
authors: Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA. mtagamet@mprc.umaryland.edu
authors: M A
authors: MA
authors: Tagamets
authors: B
authors: B
authors: Horwitz
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008959:Models, Neurological; D009415:Nerve Net / Q000166:cytology / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D009435:Synaptic Transmission / Q000502:physiology*; D014055:Tomography, Emission-Computed