title: Arrhythmogenesis in heart failure.
abstract: In a rabbit model of heart failure produced by combined pressure and volume overload, nonsustained ventricular tachycardias developed in 15 of 23 failing rabbits. Sinus rate was increased in rabbits dying suddenly, but was decreased in survivors. This also was true in isolated preparations. Microelectrode recordings from ventricular trabeculae both from patients with end-stage failure and from failing rabbits showed that in half of the preparations, delayed afterdepolarizations and triggered activity occurred, but only in the presence of norepinephrine and a lowered extracellular K+ concentration of 3 mM. This was due to spontaneous release of Ca2+ from the sarcoplasmic reticulum.
authors.affiliation: Cardiovascular Research, Academic Medical Center, University of Amsterdam, The Netherlands. M.J.Janse@amc.uva.nl
authors.forename: M J
authors.initials: MJ
authors.lastname: Janse
authors.forename: J T
authors.initials: JT
authors.lastname: Vermeulen
authors.forename: T
authors.initials: T
authors.lastname: Opthof
authors.forename: R
authors.initials: R
authors.lastname: Coronel
authors.forename: F J
authors.initials: FJ
authors.lastname: Wilms-Schopman
authors.forename: H M
authors.initials: HM
authors.lastname: Rademaker
authors.forename: A
authors.initials: A
authors.lastname: Baartscheer
authors.forename: L R
authors.initials: LR
authors.lastname: Dekker
mesh_terms: D000818:Animals; D002303:Cardiac Output, Low / Q000150:complications* / Q000209:etiology / Q000503:physiopathology; D004562:Electrocardiography; D004594:Electrophysiology; D006339:Heart Rate; D006801:Humans; D017202:Myocardial Ischemia / Q000150:complications; D012849:Sinoatrial Node / Q000503:physiopathology; D017180:Tachycardia, Ventricular / Q000209:etiology* / Q000503:physiopathology