MECHANISTIC FEATURES OF THE MO-CONTAINING NITROGENASE.
Nitrogenase is the complex metalloenzyme responsible for biological dinitrogen reduction. This reaction represents the single largest contributor to the reductive portion of the global nitrogen cycle. Recent developments in understanding the mechanism of the Mo-based nitrogenase are reviewed. Topics include how nucleotide binding and hydrolysis are coupled to electron transfer and substrate reduction, how electrons are accumulated and transferred within the MoFe-protein, and how substrates bind and are reduced at the active site metal cluster.
Christiansen
Jason
J
Department of Biochemistry, Virginia Polytechnic Institute and State University, Blacksburg, Virginia 24061; e-mail: jasonc@vt.edu deandr@vt.edu, Department of Chemistry and Biochemistry, Utah State University, Logan, Utah 84332; e-mail: seefeldt@cc.usu.edu
Dean
Dennis R
DR
Seefeldt
Lance C
LC