The relationship of CD5+ B lymphocytes to macrophages: insights from normal biphenotypic B/macrophage cells.
For decades, numerous investigators have reported derivation of macrophage-like cells from CD5(+) pre-B cell lymphomas. Recently, it has become clear that biphenotypic CD5(+) B/macrophage cells are not a spurious result of malignancy. Indeed, the existence of normal biphenotypic cells with CD5(+) B lymphocyte and macrophage characteristics has been demonstrated in the mouse. This review considers normal B/macrophage cell function in an evolutionary context where a primitive, flexible cell type could perform dual roles in adaptive and innate immunity.
Borrello
M A
MA
Vaccinex, L.P., Laboratory of Cellular Immunology, Rochester, NY, USA.
Palis
J
J
Phipps
R P
RP
D000818:Animals; D016175:B-Lymphocyte Subsets / Q000166:cytology*; D018956:CD5 Antigens / Q000032:analysis*; D002454:Cell Differentiation / Q000187:drug effects; D019070:Cell Lineage; D002999:Clone Cells; D015322:Gene Rearrangement, B-Lymphocyte; D011905:Genes, ras; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D006801:Humans; D007113:Immunity, Innate; D016130:Immunophenotyping; D008099:Liver / Q000166:cytology / Q000196:embryology; D016173:Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D008264:Macrophages / Q000166:cytology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D014411:Neoplastic Stem Cells / Q000166:cytology; D010587:Phagocytosis; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000473:pathology; D014407:Tumor Cells, Cultured
D018956:CD5 Antigens; D016173:Macrophage Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor