Effects of fosinopril or sustained-release verapamil on blood pressure and serum catecholamine concentrations in elderly hypertensive men.
A randomized, double-blind, placebo-controlled clinical trial showed 14 of 18 (78%) of the elderly hypertensive men in this study had an uncomplicated and beneficial response to either fosinopril or verapamil. There was a well-tolerated reduction in systolic blood pressure (SBP) and diastolic blood pressure (DRP). There were no significant adverse drug events. Only the sitting SBP and the sitting DBP were significantly lowered by fosinopril and verapamil SR. Because reduction in both SBP and DBP in elderly hypertensives has been shown to be beneficial, these findings take on further importance when considering the choice of medication for antihypertensive therapy in the elderly. The increase in norepinephrine in the fosinopril-treated patients may explain why patients treated with long-term angiotensin-converting enzyme inhibitors alone or in combination with diuretics rarely complain of orthostatic symptoms.
Williams
L S
LS
Department of Veterans Affairs Medical Center, Bay Pines, Florida 32608-1197, USA.
Hill
D
D
Davis
J
J
Lowenthal
D T
DT
D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology*; D001795:Blood Pressure Determination; D003692:Delayed-Action Preparations / Q000494:pharmacology / Q000627:therapeutic use; D004311:Double-Blind Method; D004837:Epinephrine / Q000097:blood* / Q000502:physiology*; D017328:Fosinopril / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood* / Q000502:physiology*; D014700:Verapamil / Q000494:pharmacology* / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D003692:Delayed-Action Preparations; D014700:Verapamil; D017328:Fosinopril; D009638:Norepinephrine; D004837:Epinephrine