Antidiabetic activity of a xanthone compound, mangiferin.
Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood glucose level of KK-Ay mice 3 weeks after oral administration (p < 0.01). However, no effect on the blood glucose level in normal mice was seen, indicating that MF could be useful in treating type-2 diabetes. In addition, MF improved hyperinsulinemia and, on insulin tolerance test, reduced blood glucose levels of KK-Ay mice. From these findings, it seems likely that MF exerts its antidiabetic activity by decreasing insulin resistance.
Miura
T
T
Suzuka University of Medical Science, Mie, Japan.
Ichiki
H
H
Hashimoto
I
I
Iwamoto
N
N
Kato
M
M
Kubo
M
M
Ishihara
E
E
Komatsu
Y
Y
Okada
M
M
Ishida
T
T
Tanigawa
K
K
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004195:Disease Models, Animal; D005960:Glucosides / Q000737:chemistry / Q000627:therapeutic use; D006946:Hyperinsulinism / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D007328:Insulin / Q000032:analysis; D007333:Insulin Resistance; D019684:Magnoliopsida / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts; D014966:Xanthenes / Q000737:chemistry / Q000627:therapeutic use*; D044004:Xanthones
D001786:Blood Glucose; D005960:Glucosides; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin