Sodium azide treatment decreases striatal and cortical concentrations of alpha-tocopherol in rats.
Sodium azide (20mg/kgsc), given for a maximum of 3 days to rats, significantly decreased the alpha-tocopherol concentrations in the cortex on day 2 and in the striatum on day 3. In these brain regions the oxidized glutathione values showed 30 to 36% (statistically not significant) elevation on day 3. Reduced glutathione levels were not altered. The observations suggest an important role for alpha-tocopherol in the defense against azide induced free radicals probably including NO and lipid peroxide radicals.
Vécsei
L
L
Department of Neurology, Albert Szent-Györgyi Medical University, Szeged, Hungary. vecsei@nepsy.szote.u-szeged.hu
Tajti
J
J
Klivényi
P
P
Pinter
S
S
Karg
E
E
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D004579:Electron Transport / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005609:Free Radicals / Q000378:metabolism*; D018698:Glutamic Acid / Q000378:metabolism; D005978:Glutathione / Q000096:biosynthesis / Q000187:drug effects; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D017072:Neostriatum / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D019636:Neurodegenerative Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D009569:Nitric Oxide / Q000096:biosynthesis; D018384:Oxidative Stress / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism; D019810:Sodium Azide / Q000494:pharmacology*; D013347:Subcellular Fractions / Q000187:drug effects / Q000378:metabolism; D014810:Vitamin E / Q000096:biosynthesis*
D004791:Enzyme Inhibitors; D005609:Free Radicals; D016194:Receptors, N-Methyl-D-Aspartate; D014810:Vitamin E; D009569:Nitric Oxide; D018698:Glutamic Acid; D019810:Sodium Azide; D005978:Glutathione