[Pharmacological effects of arginine supplementation in rats with Walker 256 solid tumor].
The effects of diet arginine supplementation for those with cancer are controversial. We evaluate the effects of dietetic supplementation with arginine over body weight, growth of tumor, metastatic dissemination, surviving time, amino acid metabolism, haematological changes of the rats with Walker 256 solid tumor. Intragastrical solutions with arginine at 4% and 6%, a standard diet (control) were administered to the animals. The supplementation with arginine was associated with a lower weight gain during the study period (p < 0.05). Surviving time of the rats with solid tumor did not vary significantly between the groups. The rate of metastase was lower in animals with Walker 256 solid tumor supplemented with arginine. The amino acid metabolism was estimulate in the animals after arginine supplementation at 4% and 6%, demonstrated by significant increases in blood levels of arginine, ornitine, citruline, proline and histidine when compared to the control group. Anaemia was less severe in the rats with Walker 256 solid tumor that received arginine supplementation. The results suggest that arginine 6% supplementation may have pharmacologic effect in rats with Walker 256 solid beyond the nutritional one.
Novaes
M R
MR
Universidade de Brasília (UnB), Centro Brasileiro de Sequenciamento de Proteínas, Departamento de Biologia Celular, Brasilia, D.F. Brasil.
Lima
L A
LA
Ribeiro
J E
JE
Magalhães
A V
AV
Sousa
M V
MV
Morhy
L
L
D000596:Amino Acids / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D001120:Arginine / Q000627:therapeutic use*; D001835:Body Weight; D002279:Carcinoma 256, Walker / Q000188:drug therapy*; D016022:Case-Control Studies; D019587:Dietary Supplements; D018572:Disease-Free Survival; D004354:Drug Screening Assays, Antitumor; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000596:Amino Acids; D001120:Arginine