title: Analgesic effects in dogs of carprofen and pethidine together compared with the effects of either drug alone.
abstract: Thirty bitches undergoing routine neutering were used in an assessor-blinded trial of the postoperative analgesic effects of pethidine and carprofen administered either together or singly. The level of analgesia was assessed by visual analogue scale (VAS) scores for pain and sedation and by nociceptive mechanical threshold testing. The two drugs administered together, and carprofen alone, provided good postoperative analgesia as assessed by VAS scoring. Pethidine alone did not provide postoperative analgesia of sufficient duration.
authors.affiliation: Division of Companion Animals, Department of Clinical Veterinary Science, University of Bristol, Langford House, Langford, Bristol BS40 5DU.
authors.forename: L S
authors.initials: LS
authors.lastname: Slingsby
authors.forename: A E
authors.initials: AE
authors.lastname: Waterman-Pearson
mesh_terms: D000759:Adjuvants, Anesthesia / Q000008:administration & dosage; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage; D002227:Carbazoles / Q000008:administration & dosage*; D004285:Dogs / Q000502:physiology* / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D007044:Hysterectomy / Q000662:veterinary*; D007279:Injections, Subcutaneous / Q000662:veterinary; D008614:Meperidine / Q000008:administration & dosage*; D010147:Pain Measurement / Q000662:veterinary; D010149:Postoperative Pain / Q000517:prevention & control / Q000662:veterinary*; D011897:Random Allocation
chemical_list: D000759:Adjuvants, Anesthesia; D000701:Analgesics, Opioid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D008614:Meperidine; C007005:carprofen