Fast (13)C-glucose metabolite mapping in rat brain using (1)H echo planar spectroscopic imaging technique at 2T.
For fast (13)C metabolite mapping in rat brains, (1)H-detected (13)C NMR spectroscopy using gradient-enhanced heteronuclear multiple-quantum coherence and (1)H echo planar spectroscopic imaging were combined. (13)C glucose and 3-/4-(13)C-Glu/Gln images of rat brain were successfully constructed with 35-minute temporal resolution under a 2T magnetic field. In the ischemic region of the suture middle cerebral artery occlusion model, glucose and Glu/Gln signals decreased and lactate signals appeared. J. Magn. Reson. Imaging 2001;13:787-791.
Morikawa
S
S
Molecular Neuroscience Research Center, Shiga University of Medical Science, Seta, Ohtsu, Shiga 520-2192, Japan. morikawa@belle.shiga-med.ac.jp
Inubushi
T
T
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002545:Brain Ischemia / Q000175:diagnosis / Q000503:physiopathology*; D001931:Brain Mapping; D017352:Echo-Planar Imaging; D004734:Energy Metabolism / Q000502:physiology*; D005973:Glutamine / Q000378:metabolism; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011237:Predictive Value of Tests; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D005973:Glutamine