Suppressive effect of caffeine on hepatitis and apoptosis induced by tumor necrosis factor-alpha, but not by the anti-Fas antibody, in mice.
Tumor necrosis factor (TNF)-alpha-induced hepatitis and apoptosis, as respectively assessed by serum enzyme activities and hepatic DNA fragmentation were effectively suppressed by a single force-feeding of caffeine (100 mg/kg) 1.5 h before injecting the drug. In contrast, caffeine had no significant effect on anti-Fas antibody-induced hepatitis and apoptosis. These results suggest that caffeine differentially affected TNF-alpha receptor- and Fas-mediated hepatitis and apoptosis.
Sugiyama
K
K
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Japan. acksugi@agr.shizuoka.ac.jp
Noda
Y
Y
He
P
P
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D017209:Apoptosis / Q000276:immunology*; D001219:Aspartate Aminotransferases / Q000097:blood; D002110:Caffeine / Q000008:administration & dosage / Q000276:immunology*; D056486:Chemical and Drug Induced Liver Injury / Q000276:immunology*; D053938:DNA Fragmentation; D004195:Disease Models, Animal; D008070:Lipopolysaccharides / Q000009:adverse effects; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000009:adverse effects* / Q000276:immunology; D019014:fas Receptor / Q000276:immunology*
D000911:Antibodies, Monoclonal; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; D019014:fas Receptor; D002110:Caffeine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase