Role of the central nervous system in hemopoiesis regulation during experimental neuroses.
Pharmacological blockade of dopamine- and serotoninergic structures with haloperidol and cyproheptadine, respectively, attenuated hyperplasia of bone marrow granulocytopoiesis and erythropoiesis (cyproheptadine) caused by conflict situation. At the same time, haloperidol and, especially, cyproheptadine normalized suppressed erythropoiesis and modulated activated granulocytopoiesis under conditions of paradoxical sleep deprivation. These results indicate that central regulation of hemopoietic stems is mediated by different neurotransmitter mechanisms. Erythropoiesis depends on the state of serotoninergic structures, while granulocytopoiesis is regulated both by the dopamine- and serotoninergic systems.
Skurikhin
E G
EG
Laboratory of Pathophysiology and Experimental Therapy, Group of Psychopharmacology, Institute of Pharmacology, Tomsk Research Center, Siberian Division of the Russian Academy of Medical Sciences.
Dygai
A M
AM
Suslov
N I
NI
Provalova
N V
NV
Zyuz'kov
G N
GN
Gol'dberg
E D
ED
D000818:Animals; D001923:Brain Chemistry; D002490:Central Nervous System / Q000502:physiology*; D003220:Conflict, Psychological; D003533:Cyproheptadine / Q000494:pharmacology*; D004195:Disease Models, Animal; D018492:Dopamine Antagonists / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D009497:Neurotic Disorders / Q000139:chemically induced / Q000503:physiopathology*; D012702:Serotonin Antagonists / Q000494:pharmacology; D012892:Sleep Deprivation
D018492:Dopamine Antagonists; D012702:Serotonin Antagonists; D003533:Cyproheptadine; D006220:Haloperidol