[Cancer of the prostate: influence of nutritional factors. A new nutritional approach].
FIBERS: A group of vegetarian subjects have been shown to have a lower risk of cancer of the prostate than a control group. But the exact role of food fiber remains to be determined because plant foods also have an antioxidant effect on their own. PLANT PRODUCTS AND EXTRACTS: A compound called PD SPEC has been showed to have antitumor effects both in vitro and in vivo. Evaluated in patients with a cancer escaping hormone control, the clinical response was a lower level of prostate specific antigen (PSA). SOYBEANS: Several studies have demonstrated the interesting properties of soybeans. No study has however been able to demonstrate the optimal dose per day. A prospective study is currently under way using a 40 g/day dose. OVERALL NUTRITIONAL APPROACH: Several studies are being conducted using a proposed diet where 15% of the total energy intake comes from fat (associated with a low saturated/unsaturated ratio), high fiber content (18 g/100 kcal) and 40 g daily soybean protein. Although large-scale studies with rigorous methodology are lacking, an overall nutritional approach could be an interesting strategy for the management of cancer of the prostate.
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Centre de Recherche chirurgicale, Service d'Urologie, Hôpital Henri Mondor, 54, boulevard du Maréchal de Lattre de Tassigny, F94100 Créteil. ad399@hotmail.com
Katz
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Vacherot
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Saint
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Salomon
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Cicco
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Abbou
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Chopin
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D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004032:Diet; D014676:Diet, Vegetarian; D004043:Dietary Fiber / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal; D002149:Energy Intake; D005737:Garlic / Q000627:therapeutic use; D019833:Genistein / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009747:Nutritional Physiological Phenomena; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy / Q000517:prevention & control* / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D012307:Risk Factors; D030262:Soybean Proteins / Q000008:administration & dosage; D013662:Tea; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D004043:Dietary Fiber; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D030262:Soybean Proteins; D013662:Tea; C114209:herbal preparation PC-SPES; D019833:Genistein; D017430:Prostate-Specific Antigen