The effect of dietary polyunsaturated fatty acid on insulin sensitivity and lipid metabolism in Otsuka Long-Evans Tokushima Fatty (OLETF) rats.
The effects of insulin sensitivity and lipid metabolism of dietary lard, eicosapentaenoic acid-rich oil (EPA oil) or arachidonic acid oil (AA oil) in Otsuka Long-Evans Tokushima Fatty (OLETF) rats were examined. Blood glucose was not different in each group at 30, 60, 120 min on an oral glucose tolerance test. Fasting blood glucose levels were lower in lard and AA oil groups than in controls. Hepatic triglyceride concentration and liver histochemistry revealed that the fat content was higher in the lard group and the AA oil group than in controls. The EPA oil group showed TG levels as high as the control group. Serum total cholesterol in the EPA oil group was lower, while the level in the AA oil group was higher than in the lard and control groups. HDL cholesterol was 1.5-fold higher in the AA oil group than in controls. Dietary EPA oil or AA oil supplementation showed different effects on lipid metabolism in this model.
Sasagawa
T
T
Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Okayama, Japan. sasagawa@fhw.oka-pu.ac.jp
Ishii
K
K
Hasuda
K
K
Kubota
M
M
Ota
Y
Y
Okita
M
M
D000818:Animals; D016718:Arachidonic Acid / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D004032:Diet; D015118:Eicosapentaenoic Acid / Q000494:pharmacology; D005223:Fats / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D051381:Rats; D020318:Rats, Long-Evans; D013997:Time Factors; D014280:Triglycerides / Q000378:metabolism
D005223:Fats; D005231:Fatty Acids, Unsaturated; D007328:Insulin; D014280:Triglycerides; D016718:Arachidonic Acid; D002784:Cholesterol; D015118:Eicosapentaenoic Acid