title: Short-term follow-up results in 795 nonpalpable probably benign lesions detected at screening mammography.
abstract: OBJECTIVE
  To evaluate short-term follow-up of nonpalpable probably benign lesions in a 2-year mammographic screening.
  
  
  METHODS
  Of 13,790 women aged 45-65 years who underwent first-round screening, 795 (5.8%) underwent short-term mammographic follow-up (every 6 months for 2 years) of nonpalpable probably benign lesions (eg, masses, focal asymmetric densities, and calcifications) previously assessed at an additional imaging evaluation, including ultrasonography. When no changes were found at short-term mammographic follow-up, women were assigned to the 2-year screening interval. Needle localization and surgical biopsy were performed when the lesion progressed (was enlarged or had an increased number or size of calcifications or modification of their initial characteristics). The effectiveness of this approach was evaluated with statistical analysis.
  
  
  RESULTS
  Of 795 lesions, 788 (99%) remained stable, and seven (1%) had changes prompting surgical biopsy. Two cancers (0.3%), one microinvasive intraductal carcinoma and one 7-mm invasive ductal carcinoma without positive nodes, were found. Four of the five benign histologic results were probably benign calcifications with progression at short-term follow-up. The sensitivity, specificity, accuracy, and positive and negative predictive values were 100%, 99%, 99%, 29%, and 100%, respectively.
  
  
  CONCLUSIONS
  The benign nature of most nonpalpable probably benign lesions can be typified with short-term mammographic follow-up. This approach permitted identification of a few low-stage carcinomas, but progression in the probably benign calcifications was usually unrelated to malignancy.
authors.affiliation: Advisory Board and Collaborative Group of Readers of the Screening Program, Public Health Office of the Health Department of the Valencia Community, Valencia, Spain. vizczino_isi@gva.es
authors.forename: I
authors.initials: I
authors.lastname: Vizcaíno
authors.forename: L
authors.initials: L
authors.lastname: Gadea
authors.forename: L
authors.initials: L
authors.lastname: Andreo
authors.forename: D
authors.initials: D
authors.lastname: Salas
authors.forename: F
authors.initials: F
authors.lastname: Ruiz-Perales
authors.forename: D
authors.initials: D
authors.lastname: Cuevas
authors.forename: C
authors.initials: C
authors.lastname: Herranz
authors.forename: F
authors.initials: F
authors.lastname: Bueno
mesh_terms: D000368:Aged; D001706:Biopsy; D001941:Breast Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000175:diagnosis / Q000000981:diagnostic imaging; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D010173:Palpation; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D016217:Ultrasonography, Mammary