title: A prospective prognostic study of the hormonal milieu at the time of surgery in premenopausal breast carcinoma.
abstract: BACKGROUND
  Despite numerous studies, the influence of timing at surgery in relation to the menstrual cycle on the prognosis of breast carcinoma is still controversial. Most studies are retrospective, and the reliability of the menstrual history data is limited by the lack of hormonal assessment at the time of surgery. The authors prospectively studied the influence of the menstrual cycle phase as determined by circulating hormones at the time of surgery on the outcome of breast carcinoma.
  
  
  METHODS
  A population of 360 premenopausal women with nonmetastatic breast carcinoma operated on from 1992 to 1995 was analyzed. Serum estradiol, progesterone, follicle-stimulating hormone (FSH), and luteinizing hormone (LH) levels were assayed the day of surgery to define the menstrual cycle phase (follicular, n = 186; ovulatory, n = 24; luteal, n = 150). The mean follow-up was 48 months.
  
  
  RESULTS
  There were no relations between the menstrual phase at surgery and tumor size, cathepsin D level, Scarff-Bloom-Richardson grade, Pg receptor (PgR), and the number of positive lymph nodes. The mean estrogen receptor level was higher during the follicular phase than in the ovulatory and luteal phases (P < 0.02). Univariate analysis of recurrence free survival (RFS) and overall survival (OS) showed no relations with the menstrual phase or the level of estradiol and progesterone at the time of surgery. High LH or FSH levels (above the medians) were associated with shorter RFS (P = 0.02 and P = 0.04, respectively) or OS (P < or = 0.01 and P = 0.01, respectively). In multivariate analysis, lymph node status, PgR status and LH level were the most significant parameters for predicting OS. There appeared to be no survival differences between menstrual cycle groups after stratification by lymph node status.
  
  
  CONCLUSIONS
  This prospective study showed a lack of prognostic value of timing at surgery in relation to the menstrual period or to estrogen and progesterone levels in premenopausal breast carcinoma. Conversely, high gonadotropin levels could predict OS independently of other prognostic factors.
authors.affiliation: Service de Biologie Cellulaire, Centre Hospitalier Universitaire de Montpellier et U540 Inserm, Montpellier, France. p-pujol@chu-montpellier.fr
authors.forename: P
authors.initials: P
authors.lastname: Pujol
authors.forename: J P
authors.initials: JP
authors.lastname: Daures
authors.forename: J P
authors.initials: JP
authors.lastname: Brouillet
authors.forename: S
authors.initials: S
authors.lastname: Chang
authors.forename: P
authors.initials: P
authors.lastname: Rouanet
authors.forename: J
authors.initials: J
authors.lastname: Bringer
authors.forename: J
authors.initials: J
authors.lastname: Grenier
authors.forename: T
authors.initials: T
authors.lastname: Maudelonde
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000401:mortality / Q000601:surgery; D002402:Cathepsin D / Q000378:metabolism; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008597:Menstrual Cycle; D015999:Multivariate Analysis; D017697:Premenopause; D011374:Progesterone / Q000097:blood*; D011379:Prognosis; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D015996:Survival Rate; D013997:Time Factors
chemical_list: D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002402:Cathepsin D