title: Scleroderma in association with the use of docetaxel (taxotere) for breast cancer.
abstract: The taxanes, paclitaxel (Taxol) and docetaxal (Taxotere), are a new class of anti-microtubule agents which have shown cytotoxic activity in a number of solid tumours. Phase I and II trials confirm that docetaxal is highly active in the treatment of metastatic breast cancer. Reported toxicities of docetaxel include, dose limiting neutropenia, alopecia, skin reactions and fluid retention. Here we report the first case of rapid onset, diffuse scleroderma-like illness, which occurred in a 59-year-old female receiving treatment with docetaxel for locally invasive and advanced metastatic breast cancer.
authors.affiliation: Department of Rheumatology, Westmead Hospital, Australia.
authors.forename: G
authors.initials: G
authors.lastname: Hassett
authors.forename: P
authors.initials: P
authors.lastname: Harnett
authors.forename: N
authors.initials: N
authors.lastname: Manolios
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy*; D000077143:Docetaxel; D005260:Female; D006801:Humans; D008875:Middle Aged; D017239:Paclitaxel / Q000009:adverse effects* / Q000031:analogs & derivatives; D012594:Scleroderma, Localized / Q000139:chemically induced*; D043823:Taxoids
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D043823:Taxoids; D000077143:Docetaxel; D017239:Paclitaxel