title: Tympanometric findings in cleft palate patients: influence of age and cleft type.
abstract: Tympanometry was analysed according to cleft type with respect to age in 239 cleft palate patients (57 with bilateral cleft lip and palate (BCLP)), 122 with unilateral cleft lip and palate (UCLP) and 60 with isolated cleft palate (ICP). The frequency of type B tympanograms was 46.5 per cent in the BCLP group, 50.6 per cent in the UCLP group and 58.3 per cent in the ICP group. Type A tympanograms were more frequently observed in older patients (median age 11 years) in comparison to type B (median age five years; p < 0.001) and type C (median age six years; p < 0.001). The total sample showed an age-related decrease in the frequency of type B tympanograms (rs = -0.3942; p < 0.001). The frequency of type A tympanograms increased significantly with age (rs = 0.4263; p < 0.001), whereas type C was not correlated with age. In the UCLP group, the frequency of type B tympanograms decreased with age (rs = -0.4430; p < 0.001), the decrease being faster than in the BCLP group (rs = -0.3186; p = 0.001) and the ICP group (rs = -0.3378; p < 0.0001)). Type B tympanograms had the highest correlation with a hearing loss of 21-40 dB at mean hearing level at speech frequencies (MHLSF) (rs = 0.4574; p < 0.001), a lower correlation with a hearing loss of 11-20 dB (rs = 0.2184; p = 0.02) and the lowest correlation with hearing loss above 40 dB. At the ages of one to three, the frequency of type B is higher in UCLP patients than in the BCLP and ICP groups, decreasing at seven to 12, increasing again at 13 to 15, and thereafter showing a continuous decrease. In the BCLP group, the frequency of type B increased significantly at the ages of four to six and then decreased continuously from seven to 18. In ICP patients, the changes in the frequency of type B with age are not significant until the age of 15; at the age of seven, it is higher than in the BCLP and ICP groups. The type C tympanogram is not typically found in cleft palate patients and its frequency is not correlated with age. It can be presumed that each type of cleft lip and palate, due to its characteristic conditions in the epipharynx, will favour a different mode of pathophysiological development of middle-ear disease.
authors.affiliation: Department of Otolaryngology, Zagreb University School of Medicine and University Clinical Hospital Centre Salata, Zagreb. jadranka.handzic-cuk@usa.net
authors.forename: J
authors.initials: J
authors.lastname: Handzić-Cuk
authors.forename: V
authors.initials: V
authors.lastname: Cuk
authors.forename: M
authors.initials: M
authors.lastname: Gluhinić
authors.forename: R
authors.initials: R
authors.lastname: Risavi
authors.forename: S
authors.initials: S
authors.lastname: Stajner-Katusić
mesh_terms: D000158:Acoustic Impedance Tests; D000293:Adolescent; D000375:Aging / Q000502:physiology; D001301:Audiometry, Pure-Tone; D002648:Child; D002675:Child, Preschool; D002971:Cleft Lip / Q000150:complications / Q000503:physiopathology / Q000601:surgery; D002972:Cleft Palate / Q000150:complications* / Q000503:physiopathology / Q000601:surgery; D004427:Ear Diseases / Q000209:etiology* / Q000503:physiopathology; D005064:Eustachian Tube / Q000503:physiopathology*; D006311:Hearing Disorders / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D011184:Postoperative Period