Frequencies of chromosome aberrations in a control population determined by G banding.
Control data on chromosome aberration frequencies determined by G banding from several studies undertaken in this laboratory have been re-analysed in relation to age and smoking. The combined study group comprised a total of 162 men (90 non-smokers and 72 smokers) with ages ranging from 20 to 72 years. For the group as a whole, significant increases were observed in translocations and all symmetrical exchanges with increasing age and also when smokers were compared with non-smokers.
Tawn
E J
EJ
Genetics Unit, Westlakes Research Institute, Westlakes Science & Technology Park, Moor Row, Cumbria, CA24 3JY, UK. ejt@westlakes.ac.uk
Whitehouse
C A
CA
D000328:Adult; D000368:Aged; D000375:Aging / Q000235:genetics; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002877:Chromosomes, Human / Q000235:genetics / Q000648:ultrastructure*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012907:Smoking / Q000235:genetics