title: Lithium intoxication due to carbamazepine-induced renal failure.
abstract: OBJECTIVE
  To report the case of a patient with manic-depressive disorder who developed lithium intoxcation following carbamazepine-induced acute renal failure.
  
  
  METHODS
  A 33-year-old white man with bipolar manic-depressive disorder was treated with lithium for the last 18 months. Three weeks prior to admission, carbamazepine 600 mg was added to the drug regimen due to a recurrence of the psychiatric disorder. He was admitted wh signs of lithium intoxication. Acute renal failure due to carbamazepine-induced interstitial nephritis was diagnosed.
  
  
  CONCLUSIONS
  The combination of carbamazepine and lithium is known to cause neurotoxicity. We describe a different interaction in which the toxic lithium concentrations were the result of carbamazepine-induced acute renal failure.
  
  
  CONCLUSIONS
  When considering adding carbamazepine to lithium, careful follow-up of the patients is warranted to prevent this indirect drug in interaction.
authors.affiliation: Department of Medicine E, Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel. mayan@post.tau.ac.il
authors.forename: H
authors.initials: H
authors.lastname: Mayan
authors.forename: N
authors.initials: N
authors.lastname: Golubev
authors.forename: D
authors.initials: D
authors.lastname: Dinour
authors.forename: Z
authors.initials: Z
authors.lastname: Farfel
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D002220:Carbamazepine / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D008094:Lithium / Q000009:adverse effects*; D008297:Male
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D008094:Lithium