title: [Multiple myeloma complicated by bilateral abducens nerve palsy due to a tumor in the clivus].
abstract: A 62-year-old woman was admitted to our hospital because of double vision. Bone marrow aspiration revealed normal cellularity with 21.6% atypical plasma cells. Immunoelectrophoresis revealed a monoclonal component of IgG kappa in the patient's serum. Coronal and sagittal cranial MRI images showed a tumor in the clivus behind the sella turcica. The patient was diagnosed as having multiple myeloma complicated by double vision due to compression of the bilateral abducens nerve by a plasmacytoma. VAD therapy consisting of vincristine, doxorubicin and dexamethasone, followed by irradiation of the clivus tumor achieved only a transient therapeutic effect, and the double vision and bone disease worsened. Cranial nerve palsy may be a significant complication of multiple myeloma.
authors.affiliation: First Department of Internal Medicine, Gifu University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Kanemura
authors.forename: H
authors.initials: H
authors.lastname: Tsurumi
authors.forename: T
authors.initials: T
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Sawada
authors.forename: H
authors.initials: H
authors.lastname: Moriwaki
mesh_terms: D020434:Abducens Nerve Diseases / Q000209:etiology*; D003388:Cranial Fossa, Posterior; D003389:Cranial Nerve Diseases / Q000209:etiology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis; D019292:Skull Base Neoplasms / Q000150:complications* / Q000175:diagnosis