Allogeneic transplantation of blood stem cells: coming of age?
Mobilized peripheral blood progenitor cells (PBSC) are increasingly being used instead of bone marrow for allogeneic transplantation. The purpose of the present article is to give a concise and clinically oriented overview on current results and perspectives of allogeneic peripheral blood stem cell transplantation, with particular focus on reconstitution of hematopoiesis and the immune system, graft-versus-host disease, graft-versus-leukemia effects, intensity-reduced conditioning, and graft engineering.
Dreger
P
P
Second Department of Medicine, University of Kiel, Chemnitzstrasse 33, 24116 Kiel, Germany. p.dreger@med2.uni-kiel.de
Schmitz
N
N
D006086:Graft vs Host Disease; D020544:Graft vs Leukemia Effect; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007938:Leukemia / Q000628:therapy; D013601:T-Lymphocytes; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous