Spliceosomal UsnRNP biogenesis, structure and function.
Significant advances have been made in elucidating the biogenesis pathway and three-dimensional structure of the UsnRNPs, the building blocks of the spliceosome. U2 and U4/U6*U5 tri-snRNPs functionally associate with the pre-mRNA at an earlier stage of spliceosome assembly than previously thought, and additional evidence supporting UsnRNA-mediated catalysis of pre-mRNA splicing has been presented.
Will
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CL
Max Planck Institute of Biophysical Chemistry, Department of Cellular Biochemistry, Am Fassberg 11, 37077 Göttingen, Germany. cwill1@gwdg.de
Lührmann
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D000818:Animals; D003461:Crystallography; D006801:Humans; D046911:Macromolecular Substances; D017434:Protein Structure, Tertiary / Q000502:physiology; D021381:Protein Transport / Q000502:physiology; D012326:RNA Splicing / Q000235:genetics / Q000502:physiology; D012342:RNA, Small Nuclear / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D017412:Ribonucleoprotein, U1 Small Nuclear / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D017411:Ribonucleoproteins, Small Nuclear / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D017381:Spliceosomes / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*
D046911:Macromolecular Substances; D012342:RNA, Small Nuclear; D017412:Ribonucleoprotein, U1 Small Nuclear; D017411:Ribonucleoproteins, Small Nuclear; C405482:U4 small nuclear RNA