title: Brain metastases of a malignant fibrous histiocytoma presenting as an acute cerebral hemorrhage.
abstract: Intracranial metastases from malignant fibrous histiocytoma (MFH) are rare, particularly with associated hemorrhage. This article reports one case and presents a review of the literature on this topic. A 55-year-old man presented with acute drowsiness, aphasia and right homonymous hemianopsia and hemiparesis. The first CT scan showed a left occipitoparietal hematoma and the second one, nodular, contrast-enhanced lesions. He had been previously operated on soft tissues MFH. Lung metastases developed subsequently. A craniotomy was performed with evacuation of the hematoma and total gross resection of the mass lesions. Microscopic examination disclosed a metastasis from a MFH. Neoangiogenesis, stimulated by angiogenic growth factors, seems to take part in this vascular, stroke-like event. Due to longer survivals of patients harboring systemic sarcomas, these tumors should be considered in the differential diagnosis of intracranial neoplasms, whether hemorrhagic or not. In particular, history of a previous soft tissue or heart tumor associated with lung metastasis should evoke the possibility of MFH metastasis.
authors.affiliation: Department of Neurology, Hospital de Santa Maria, Lisbon, Portugal. cortezpimentel@ip.pt
authors.forename: J
authors.initials: J
authors.lastname: Pimentel
authors.forename: A C
authors.initials: AC
authors.lastname: Fernandes
authors.forename: R
authors.initials: R
authors.lastname: Silva
authors.forename: J
authors.initials: J
authors.lastname: Ferro
authors.forename: B
authors.initials: B
authors.lastname: Cattoni
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000473:pathology / Q000556:secondary*; D002543:Cerebral Hemorrhage / Q000473:pathology*; D003937:Diagnosis, Differential; D018219:Histiocytoma, Benign Fibrous / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology; D009778:Occipital Lobe / Q000473:pathology*; D010296:Parietal Lobe / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor