title: Spectrophotometric determination of manidipine dihydrochloride based on formation of charge-transfer complex with iodine.
abstract: A new spectrophotometric method for determining manidipine dihydrochloride has been developed. The method was based on the formation of charge transfer complex between this drug as n-donor and iodine the s-acceptor. The iodine was found to form charge-transfer complex in a 1:1 stoichiometry with absorption bands at 290 and 353 nm. Conformity to Beer's law enabled the assay of dosage forms of this drug, the concentration range for the best accuracy is 3-11 micrograms/ml. The method can be applied successfully to the analysis of commercially available manidipine dihydrochloride tablets.
authors.affiliation: Department of Medicinal Chemistry-Faculty of Pharmacy, University of Bari, Italy.
authors.forename: N
authors.initials: N
authors.lastname: De Laurentis
authors.forename: V
authors.initials: V
authors.lastname: Losacco
authors.forename: M A
authors.initials: MA
authors.lastname: Milillo
authors.forename: A
authors.initials: A
authors.lastname: Zarrilli
mesh_terms: D002121:Calcium Channel Blockers / Q000032:analysis*; D002138:Calibration; D004095:Dihydropyridines / Q000032:analysis*; D007455:Iodine / Q000737:chemistry*; D009578:Nitrobenzenes; D019999:Pharmaceutical Solutions; D010879:Piperazines; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
chemical_list: D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D009578:Nitrobenzenes; D019999:Pharmaceutical Solutions; D010879:Piperazines; D013607:Tablets; C054218:manidipine; D007455:Iodine