title: Carriage of antibiotic-resistant pneumococci among Asian children: a multinational surveillance by the Asian Network for Surveillance of Resistant Pathogens (ANSORP).
abstract: To investigate the nasal carriage of antibiotic-resistant pneumococci by children, anterior nasal swabs were done for 4963 children <5 years old in 11 countries in Asia and the Middle East. In total, 1105 pneumococci isolates (carriage rate, 22.3%) were collected, 35.8% of which were found to be nonsusceptible to penicillin. Prevalence of penicillin nonsusceptibility was highest in Taiwan (91.3%), followed by Korea (85.8%), Sri Lanka (76.5%), and Vietnam (70.4%). Penicillin resistance was related to residence in urban areas, enrollment in day care, and a history of otitis media. The most common serogroups were 6 (21.5%), 23 (16.5%), and 19 (15.7%). The most common clone, as assessed by pulsed-field gel electrophoresis, was identical to the Spanish 23F clone and to strains of invasive isolates from adult patients. Data in this study documented the high rate of penicillin or multidrug resistance among isolates of pneumococci carried nasally in children in Asia and the Middle East and showed that this is due to the spread of a few predominant clones in the region.
authors.affiliation: Samsung Medical Center, Sungkyunkwan University, Seoul, Korea.
authors.forename: N Y
authors.initials: NY
authors.lastname: Lee
authors.forename: J H
authors.initials: JH
authors.lastname: Song
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: K R
authors.initials: KR
authors.lastname: Peck
authors.forename: K M
authors.initials: KM
authors.lastname: Ahn
authors.forename: S I
authors.initials: SI
authors.lastname: Lee
authors.forename: Y
authors.initials: Y
authors.lastname: Yang
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: Chongthaleong
authors.forename: S
authors.initials: S
authors.lastname: Tiengrim
authors.forename: N
authors.initials: N
authors.lastname: Aswapokee
authors.forename: T Y
authors.initials: TY
authors.lastname: Lin
authors.forename: J L
authors.initials: JL
authors.lastname: Wu
authors.forename: C H
authors.initials: CH
authors.lastname: Chiu
authors.forename: M K
authors.initials: MK
authors.lastname: Lalitha
authors.forename: K
authors.initials: K
authors.lastname: Thomas
authors.forename: T
authors.initials: T
authors.lastname: Cherian
authors.forename: J
authors.initials: J
authors.lastname: Perera
authors.forename: T T
authors.initials: TT
authors.lastname: Yee
authors.forename: F
authors.initials: F
authors.lastname: Jamal
authors.forename: U C
authors.initials: UC
authors.lastname: Warsa
authors.forename: P H
authors.initials: PH
authors.lastname: Van
authors.forename: C C
authors.initials: CC
authors.lastname: Carlos
authors.forename: A M
authors.initials: AM
authors.lastname: Shibl
authors.forename: M R
authors.initials: MR
authors.lastname: Jacobs
authors.forename: P C
authors.initials: PC
authors.lastname: Appelbaum
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001208:Asia / Q000453:epidemiology; D002353:Carrier State / Q000453:epidemiology* / Q000382:microbiology; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008826:Microbial Sensitivity Tests; D009305:Nasopharynx / Q000382:microbiology; D010403:Penicillin Resistance / Q000235:genetics; D011008:Pneumococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D011159:Population Surveillance; D012703:Serotyping; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects* / Q000235:genetics
chemical_list: D000900:Anti-Bacterial Agents