Rotavirus infection as cause of tacrolimus elevation in solid-organ-transplanted children.
Rotavirus (RV) is the most common cause of diarrheal illness in children. We report three solid-organ-transplanted patients in whom RV infection caused increased trough levels of the immunosuppressive macrolide tacrolimus (TAC) by mechanisms that are still under investigation. The virus was detected for longer in the feces of these patients than in infants not receiving immunosuppressive therapy. In association with short-term monitoring of blood trough levels of TAC, the dosage should be reduced early if symptoms of an acute gastroenteritis are present.
Frühwirth
M
M
Department of Pediatrics, Department of Transplantation Surgery, School of Medicine, University of Innsbruck, Anichstrasse 356, A-6020 Innsbruck, Austria. Martin.Fruehwirth@uibk.ac.at
Fischer
H
H
Simma
B
B
Hochleitner
B
B
Königsrainer
A
A
Margreiter
R
R
Ellemunter
H
H
D000328:Adult; D002648:Child; D003967:Diarrhea / Q000097:blood* / Q000821:virology*; D016903:Drug Monitoring; D005243:Feces / Q000821:virology; D005260:Female; D005759:Gastroenteritis / Q000097:blood / Q000821:virology; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000097:blood*; D007223:Infant; D016030:Kidney Transplantation; D016031:Liver Transplantation; D016040:Lung Transplantation; D008297:Male; D011183:Postoperative Complications / Q000097:blood*; D012400:Rotavirus Infections / Q000097:blood*; D016559:Tacrolimus / Q000008:administration & dosage / Q000097:blood*; D014180:Transplantation
D007166:Immunosuppressive Agents; D016559:Tacrolimus