[Chiral ion-pair chromatography].
A chiral counter-ion dissolved in the mobile phase can be used to separate enantiomers of acids and amines. The principles and related separation variables have been reviewed. A successful enantiomeric separation is highly dependent on the features of counter-ion chosen for the experiments. The most important properties of a suitable chiral reagent can be summarized as follows: (1) acid-base character of counter-ion; (2) hydrophobicity of counter-ions; (3) presence of suitable functional groups; (4) enantiomeric purity of counter-ion, etc. It is also discussed about the influences of various chromatographic conditions and the applications of chiral ion-pair chromatography.
Li
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X
Dept. of Pharmaceutical Analysis, School of Pharmacy, Zhejiang Medical University, Hangzhou, 310031.
Zeng
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D000588:Amines / Q000302:isolation & purification; D000596:Amino Acids / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000379:methods*; D009281:Naphthalenes
D000588:Amines; D000596:Amino Acids; C108741:C2-symmetric binaphthyl phosphortriamide; D009281:Naphthalenes