Multidrug resistance and ABC transporters in parasitic protozoa.
Drug resistance is an important problem in parasitic protozoa. We review here the role of ABC transporters in drug resistance in parasites. We have concentrated on gene and gene products for which there is a strong evidence for their role in resistance.
Ouellette
M
M
Centre de Recherche en Infectiologie du Centre de Recherche du CHUL and Département de Microbiologie, Faculté de Médecine, Université Laval, Ste-Foy, Québec, Canada. Marc.Ouellette@crchul.ulaval.ca
Légaré
D
D
Papadopoulou
B
B
D018528:ATP-Binding Cassette Transporters / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology; D000981:Antiprotozoal Agents / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D056890:Eukaryota / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D006801:Humans; D007891:Leishmania / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D008288:Malaria / Q000469:parasitology; D016778:Malaria, Falciparum / Q000469:parasitology; D010963:Plasmodium falciparum / Q000187:drug effects / Q000235:genetics / Q000502:physiology
D018528:ATP-Binding Cassette Transporters; D000962:Antimalarials; D000981:Antiprotozoal Agents