[Effects of noradrenaline on delayed outward potassium current in isolated rat hepatocytes].
Heretofore no reports are available on the outward potassium currents in rat hepatocytes. Using whole-cell patch clamp technique, the effects of noradrenaline and other reagents on the delayed outward potassium current (IK) in isolated rat hepatocytes were investigated. The experimental results showed that the magnitude of IK was 2.85 +/- 1.21 nA at a command potential of +140 mV from a holding potential of -50 mV. Noradrenaline decreased IK distinctly. Isoprenaline and acetylcholine showed no effect on IK in isolated rat hepatocytes.
Cui
G Y
GY
Department of Pharmacology, China Medical University, Shenyang 110001.
Li
J M
JM
Liu
D J
DJ
Cui
H
H
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D002469:Cell Separation; D022781:Hepatocytes / Q000187:drug effects*; D008297:Male; D008564:Membrane Potentials; D009638:Norepinephrine / Q000494:pharmacology*; D018408:Patch-Clamp Techniques; D011188:Potassium / Q000378:metabolism*; D015221:Potassium Channels / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D000316:Adrenergic alpha-Agonists; D015221:Potassium Channels; D011188:Potassium; D009638:Norepinephrine