Identification of a novel member of the T1R family of putative taste receptors.
In the gustatory system, the recognition of sugars, amino acids and bitter-tasting compounds is the function of specialized G protein-coupled receptors. Recently, two members of novel subfamily of G protein-coupled receptors were proposed to function as taste receptors based on their specific expression in taste receptor cells. Here, we report the identification of a third member, T1R3, of this family of receptors. T1R3 maps near the telomere of mouse chromosome 4 rendering it a candidate for the Sac locus, a primary determinant of sweet preference in mice. Consistent with its candidacy for the Sac locus, T1R3 displays taste receptor cell-specific expression. In addition, taster and non-taster strains of mouse harbor different alleles of T1R3.
Sainz
E
E
Laboratory of Molecular Biology, National Institute on Deafness and Other Communication Disorders, National Institutes of Health, Rockville, MD 20850, USA.
Korley
J N
JN
Battey
J F
JF
Sullivan
S L
SL
D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D015870:Gene Expression; D017403:In Situ Hybridization; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009831:Olfactory Mucosa / Q000737:chemistry; D021382:Protein Sorting Signals; D051381:Rats; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000737:chemistry / Q000235:genetics; D043562:Receptors, G-Protein-Coupled; D016415:Sequence Alignment; D013649:Taste / Q000235:genetics; D013650:Taste Buds / Q000737:chemistry; D014059:Tongue / Q000166:cytology
D021382:Protein Sorting Signals; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C431926:taste receptors, type 1