title: Cognitive functional status of age-confirmed centenarians in a population-based study.
abstract: The New England Centenarian Study is a population-based study of all centenarians in 8 towns near Boston, MA. Age was confirmed for 43 centenarians all alive on a designated date. To determine prevalence of dementia in centenarians, the authors analyzed neuropsychological, medical, and functional status data for 34 (79%) of the centenarians. Definition of dementia was based on the Consortium to Establish a Registry for Alzheimer's Disease criteria, and a Clinical Dementia Rating (CDR) score was formulated for each participant. Seven (21%) had no dementia (CDR score 0), and an additional 4 (12%) were assigned a CDR score of 0.5, uncertain or deferred diagnosis. The remaining 22 (64%) had at least some degree of dementia. The authors calculated Barthel Index scores to determine ability to perform activities of daily living. There was a statistically significant correlation between CDR scores and Barthel Index scores (r = -0.73). Correlation was strongest for those with no or severe dementia, with the greatest range of function measured among those with moderate dementia.
authors.affiliation: Division on Aging, Harvard Medical School, Boston, Massachusetts, USA. margery_silver@hms.harvard.edu
authors.forename: M H
authors.initials: MH
authors.lastname: Silver
authors.forename: E
authors.initials: E
authors.lastname: Jilinskaia
authors.forename: T T
authors.initials: TT
authors.lastname: Perls
mesh_terms: D000203:Activities of Daily Living; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001900:Boston / Q000453:epidemiology; D003071:Cognition; D003704:Dementia / Q000145:classification / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D015577:Geriatric Assessment; D006304:Health Status; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011159:Population Surveillance; D015995:Prevalence; D012042:Registries; D012720:Severity of Illness Index