title: Foetal amygdalar transplantation facilitates recovery of retention deficit in CeA lesioned rats.
abstract: Neural tissue transplant has come off age as a valuable technique for studying normal development and regeneration. Bilateral lesions of the central nucleus of amygdala (CeA) produce complete retention and acquisition deficit in inhibitory avoidance paradigms. The present study reports recovery of retention deficit in active avoidance task (AA) after amygdalar tissue transplantation in CeA lesioned rats. In a group of adult wistar rats, bilateral lesions of the CeA were produced electrolytically. In a separate group of rats foetal amygdalar tissue was transplanted at the CeA lesioned site 2 days after producing lesion. All the rats were trained on AA task before and after 5 days of lesion. In bilaterally CeA lesioned rats, the percentage of avoidance (% avoidance) decreased significantly (P < 0.05) from 85 +/- 18% prelesion to 15.5 +/- 35% postlesion. However, no change in the % avoidance was observed after amygdalar tissue transplantation. The results indicate that the transplanted rats are capable of retaining the learnt information in contrast to the lesion alone group of rats.
authors.affiliation: Department of Physiology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi-110029, India. suman@medinst.ernet.in
authors.forename: S
authors.initials: S
authors.lastname: Jain
authors.forename: R
authors.initials: R
authors.lastname: Mathur
authors.forename: R
authors.initials: R
authors.lastname: Sharma
mesh_terms: D000679:Amygdala / Q000196:embryology / Q000473:pathology / Q000637:transplantation*; D000818:Animals; D005260:Female; D016332:Fetal Tissue Transplantation; D008297:Male; D008569:Memory Disorders / Q000628:therapy*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar