title: Regulation and function of the p53 tumor suppressor protein.
abstract: Loss of the p53 tumor suppressor pathway contributes to the development of most human cancers. p53 is a nuclear protein that functions as a regulator of transcription. Significant advances have been made recently in our understanding of how p53 function is regulated and the mechanisms by which p53 mediates its effects.
authors.affiliation: Regulation of Cell Growth Laboratory, Building 560, Room 22-96, National Cancer Institute at Frederick, Frederick, MD 21702, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Ryan
authors.forename: A C
authors.initials: AC
authors.lastname: Phillips
authors.forename: K H
authors.initials: KH
authors.lastname: Vousden
mesh_terms: D021581:Active Transport, Cell Nucleus / Q000502:physiology; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D002451:Cell Compartmentation / Q000502:physiology*; D002453:Cell Cycle / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology; D006801:Humans; D009154:Mutation / Q000235:genetics; D009369:Neoplasms / Q000473:pathology* / Q000503:physiopathology*; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*; D016159:Tumor Suppressor Protein p53 / Q000235:genetics / Q000378:metabolism*
chemical_list: D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53