title: Resistance of cattle to scrapie by the oral route.
abstract: Early epidemiological information indicated that bovine spongiform encephalopathy (BSE) originated from scrapie in sheep. The question arose if scrapie in North America would induce a BSE-like disease in cattle. Six years ago, we reported that brain tissue from sheep with scrapie caused a neurologic disease when injected directly into the brains of cattle, but the disease induced was different from BSE as it occurs in the United Kingdom and Europe. Here, we report that cattle fed raw brain or meat and bone meal and tallow prepared from sheep with scrapie remained normal for 8 years after exposure. This work indicates that cattle are highly resistant to North American scrapie by the oral route.
authors.affiliation: Agricultural Research Service, National Animal Disease Center, United States Department of Agriculture, Ames, Iowa 50010. rcutlip@nadc.ars.usda.gov
authors.forename: R C
authors.initials: RC
authors.lastname: Cutlip
authors.forename: J M
authors.initials: JM
authors.lastname: Miller
authors.forename: A N
authors.initials: AN
authors.lastname: Hamir
authors.forename: J
authors.initials: J
authors.lastname: Peters
authors.forename: M M
authors.initials: MM
authors.lastname: Robinson
authors.forename: A L
authors.initials: AL
authors.lastname: Jenny
authors.forename: H D
authors.initials: HD
authors.lastname: Lehmkuhl
authors.forename: W D
authors.initials: WD
authors.lastname: Taylor
authors.forename: F D
authors.initials: FD
authors.lastname: Bisplinghoff
mesh_terms: D000818:Animals; D002417:Cattle; D016643:Encephalopathy, Bovine Spongiform / Q000453:epidemiology / Q000209:etiology*; D007113:Immunity, Innate; D009656:North America / Q000453:epidemiology; D012608:Scrapie / Q000453:epidemiology*