Genes, models and Alzheimer's disease.
Alzheimer's disease (AD) is a neurodegenerative disorder that is claiming an increasing number of victims as the world population ages. The identification of gene mutations and polymorphisms that either cause AD or significantly increase the risk for developing it enabled the creation of a whole generation of realistic rodent models of the disease. Animals expressing mutated human amyloid precursor protein and presenilin 1 show dramatic parallels to AD, although none of the models appear to capture the full range of pathologies that characterize the human disease. Increased refinement of these models will enhance the already tantalizing possibility of treatment.
Chapman
P F
PF
Cardiff School of Biosciences, Cardiff University, Biomedical Sciences Building, PO Box 911, Cardiff, UK CF10 3US. chapmanPF@cardiff.ac.uk
Falinska
A M
AM
Knevett
S G
SG
Ramsay
M F
MF
D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D000818:Animals; D001057:Apolipoproteins E / Q000235:genetics; D004195:Disease Models, Animal; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics; D008565:Membrane Proteins / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D053764:Presenilin-1; D012307:Risk Factors
D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D007375:Interleukin-1; D008565:Membrane Proteins; C508853:PSEN1 protein, human; D053764:Presenilin-1