[The effect of anthocyanin dye from grapes on experimental diabetes].
In the work an effect of anthocyanins of red wine type Cabernet on the course and intensity of symptoms of the experimental diabetes in the rats has been examined. The estimation of the course of experimental diabetes was based on: determination of sugar concentration in urine and blood serum, determination of concentration of the unsaturated fatty acids peroxidation in urine and blood serum, also on the change of body mass during the experiment. The examination was carried out on 80, weighing 200-250 g, rats. They lived in the animal quarters with a stable temperature and humidity being fed with standard fodder (Murigan) with water supply in ever quantity. The rats were divided into the following four group: I--control group, II--group of animals receiving intraperitoneal streptozotocin in concentration 70 mg/kg m.c., III--group of animals receiving intragastric 10 mg/kg m.c. of natural anthocyanin dye of red wine type Cabernet, IV--group of animals receiving intraperitoneal 70 mg/kg m.c. of streptozotocin and simultaneously receiving intragastric 1 mg/kg m.c. of natural anthocyanin dye. An essential increase of glucose concentration in urine was found in the rats after streptozotocin injection. A simultaneous daily administration of anthocyanins obtained from red wine type Cabernet and streptozotocin substantially decreased sugar concentration in urine and blood serum. Those anthocyanins also inhibited loss of body mass caused by the former injection of streptozotocin. Simultaneously antocyan pigment was stated to considerably prevent generation of free oxygen radicals. The decrease of peroxidation of lipids, the measure of which was lowering of the concentration of the products of unsaturated fatty acids oxidation in urine and blood serum was also observed.
Jankowski
A
A
Zakład Organizacji Ochrony Zdrowia Wojsk i Zarzadzania w Słuzbie Zdrowia Wojskowa Akademia Medyczna ul. Zeligowskiego 7/9, 94-752 Łódź.
Jankowska
B
B
Niedworok
J
J
D000818:Animals; D000872:Anthocyanins / Q000008:administration & dosage*; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D015992:Body Mass Index; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000097:blood / Q000652:urine; D005260:Female; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales; D013311:Streptozocin
D000872:Anthocyanins; D001786:Blood Glucose; D005231:Fatty Acids, Unsaturated; D013311:Streptozocin