title: The WWE domain: a common interaction module in protein ubiquitination and ADP ribosylation.
abstract: Sequence profile analysis was used to detect a conserved globular domain in several proteins including deltex, Trip12 and poly-ADP-ribose polymerase homologs. It was named the WWE domain after its most conserved residues and is predicted to mediate specific protein-protein interactions in ubiquitin and ADP-ribose conjugation systems.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA. aravind@ncbi.nlm.nih.gov
authors.forename: L
authors.initials: L
authors.lastname: Aravind
mesh_terms: D020727:ADP-Ribosylation Factors / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D029721:Drosophila Proteins; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry; D008025:Ligases / Q000737:chemistry; D008565:Membrane Proteins; D008969:Molecular Sequence Data; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D012984:Software; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism*
chemical_list: C086679:DX protein, Drosophila; D029721:Drosophila Proteins; D019476:Insect Proteins; D008565:Membrane Proteins; D014452:Ubiquitins; D044767:Ubiquitin-Protein Ligases; D011065:Poly(ADP-ribose) Polymerases; D020727:ADP-Ribosylation Factors; D008025:Ligases