Lhermitte duclos disease and Cowden disease: clinical, pathological and neuroimaging study of a case.
The authors report the case of a 26-year-old female patient affected by Lhermitte Duclos disease and Cowden disease. Preoperative MRI allowed a correct diagnosis which was confirmed by pathological examination. The authors stress the possibility that Lhermitte Duclos and Cowden disease be a single phakomatosis; for this reason all the patients affected by Lhermitte-Duclos should be screened for the presence of multiple hamartomas or malignant neoplastic lesions typical of Cowden disease.
Barone
F
F
Division of Neurosurgery, Azienda Ospedaliera di Rilievo Nazionale Garibaldi, Ascoli-Tomaselli, S. Luigi-S. Curro, Catania, Italy.
Noubari
B A
BA
Torrisi
A
A
Lanzafame
S
S
Tropea
R
R
Mancuso
P
P
D000328:Adult; D002526:Cerebellar Diseases / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D002528:Cerebellar Neoplasms / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D005260:Female; D006223:Hamartoma Syndrome, Multiple / Q000150:complications* / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D008279:Magnetic Resonance Imaging; D009474:Neurons / Q000473:pathology; D014057:Tomography, X-Ray Computed