Spectrophotometric determination of manidipine dihydrochloride based on formation of charge-transfer complex with iodine.
A new spectrophotometric method for determining manidipine dihydrochloride has been developed. The method was based on the formation of charge transfer complex between this drug as n-donor and iodine the s-acceptor. The iodine was found to form charge-transfer complex in a 1:1 stoichiometry with absorption bands at 290 and 353 nm. Conformity to Beer's law enabled the assay of dosage forms of this drug, the concentration range for the best accuracy is 3-11 micrograms/ml. The method can be applied successfully to the analysis of commercially available manidipine dihydrochloride tablets.
De Laurentis
N
N
Department of Medicinal Chemistry-Faculty of Pharmacy, University of Bari, Italy.
Losacco
V
V
Milillo
M A
MA
Zarrilli
A
A
D002121:Calcium Channel Blockers / Q000032:analysis*; D002138:Calibration; D004095:Dihydropyridines / Q000032:analysis*; D007455:Iodine / Q000737:chemistry*; D009578:Nitrobenzenes; D019999:Pharmaceutical Solutions; D010879:Piperazines; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D009578:Nitrobenzenes; D019999:Pharmaceutical Solutions; D010879:Piperazines; D013607:Tablets; C054218:manidipine; D007455:Iodine