title: Implant fixation enhanced by intermittent treatment with parathyroid hormone.
abstract: The intermittent administration of parathyroid hormone (PTH) increases the formation of bone by stimulating osteoblastic activity. Our study evaluates the possibility that intermittent treatment with PTH (1-34) may also enhance the implant-bone fixation of stainless-steel screws. Twenty-eight rats received one screw in either one (n = 8) or in both (n = 20) proximal tibiae. We administered either PTH (1-34) in a dosage of 60 microg/kg/day (n = 14) or vehicle (n = 14) over a period of four weeks. At the end of this time, the degree of fixation was assessed by measuring the removal torque on one screw in each rat (n = 28) and the pull-out strength on the contralateral screw (n = 20). PTH increased the mean removal torque from 1.1 to 3.5 Ncm (p = 0.001) and the mean pull-out strength from 66 to 145 N (p = 0.002). No significant differences in body-weight or ash weight of the femora were seen. Histological examination showed that both groups had areas of soft tissue at the implant-bone interface, but these appeared less in the PTH group. These results indicate that intermittent treatment with PTH may enhance the early fixation of orthopaedic implants.
authors.affiliation: Department of Orthopaedics, Lund University Hospital, Sweden.
authors.forename: R
authors.initials: R
authors.lastname: Skripitz
authors.forename: P
authors.initials: P
authors.lastname: Aspenberg
mesh_terms: D000818:Animals; D015519:Bone Density / Q000187:drug effects; D001863:Bone Screws; D005593:Fracture Fixation, Internal / Q000379:methods*; D010281:Parathyroid Hormone / Q000008:administration & dosage*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010281:Parathyroid Hormone