title: Caveolin-1 expression in advanced-stage ovarian carcinoma--a clinicopathologic study.
abstract: OBJECTIVE
  The aim of this study was to analyze the correlation among the expression of caveolin-1, the protein constituent of caveolae, and disease outcome in advanced-stage ovarian carcinomas.
  
  
  METHODS
  Sections from 76 primary ovarian carcinomas and metastatic lesions from 45 patients diagnosed with advanced-stage ovarian carcinoma (FIGO stages III-IV) were evaluated for caveolin-1 expression using immunohistochemistry. Patients were divided into long-term survivors and short-term survivors based on disease outcome. Twenty nonneoplastic fallopian tubes and ovaries were additionally studied.
  
  
  RESULTS
  The mean follow-up period was 70 months. The mean values for disease-free survival and overall survival were 109 and 125 months for long-term survivors, compared to 3 and 21 months for short-term survivors, respectively. Caveolin-1 expression was localized to the cell membrane in 24/76 (32%) specimens and was detected in the cytoplasm in 52/76 (68%) cases. Both patterns were more often detected in metastases, when compared with primary tumors. In addition, membrane immunoreactivity was more often seen in tumor of short-term survivors. These differences did not reach statistical significance (P > 0.05). Combined membrane and cytoplasmic immunoreactivity was seen in 17/20 (85%) nonneoplastic lesions. Despite its role in tyrosine-kinase-mediated signal transduction in vitro studies, caveolin-1 expression in carcinomas showed no association with the protein expression of c-erbB-2 and epidermal growth factor receptor, evaluated in a previous study of this patient cohort.
  
  
  CONCLUSIONS
  This study provides the first in vivo evidence of caveolin-1 membrane expression in human malignancies. Caveolin-1 is often expressed in advanced-stage ovarian carcinoma, but does not appear to be a powerful predictor of disease outcome in these tumors. The reduced expression level in carcinomas compared to nonneoplastic epithelium may point to a role for caveolin-1 as a tumor suppressor gene.
authors.affiliation: Department of Pathology, The Norwegian Radium Hospital, Montebello, Oslo N-0310, Norway. bend@ulrik.uio.no
authors.forename: B
authors.initials: B
authors.lastname: Davidson
authors.forename: J M
authors.initials: JM
authors.lastname: Nesland
authors.forename: I
authors.initials: I
authors.lastname: Goldberg
authors.forename: J
authors.initials: J
authors.lastname: Kopolovic
authors.forename: W H
authors.initials: WH
authors.lastname: Gotlieb
authors.forename: M
authors.initials: M
authors.lastname: Bryne
authors.forename: G
authors.initials: G
authors.lastname: Ben-Baruch
authors.forename: A
authors.initials: A
authors.lastname: Berner
authors.forename: R
authors.initials: R
authors.lastname: Reich
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis; D051242:Caveolin 1; D022461:Caveolins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009367:Neoplasm Staging; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology*; D011379:Prognosis
chemical_list: D014408:Biomarkers, Tumor; C495540:CAV1 protein, human; D051242:Caveolin 1; D022461:Caveolins