Synthesis and in vitro antibacterial activity of cephalosporins with a pyridinium substituent carrying an isoxazole moiety at the C-3 position.
Several quaternary pyridinium cephalosporin analogues were prepared and evaluated in vitro for antibacterial activity against selected gram-positive and gram-negative organisms. Most of the synthesized analogues were either as effective or less effective against the tested bacterial organisms than the reference compounds, Cefpirome and Ceftazidime.
Park
H
H
College of Pharmacy, Kangwon National University, Chunchon, Korea. haeilp@cc.kangwon.ac.kr
Choi
H
H
Lang
J
J
Choi
S
S
Rhee
J
J
Chang
M
M
D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology*; D007555:Isoxazoles / Q000138:chemical synthesis* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D013210:Staphylococcus / Q000187:drug effects; D013329:Structure-Activity Relationship
D002511:Cephalosporins; D007555:Isoxazoles; D011726:Pyridinium Compounds