Immunoregulatory role of secreted glycoprotein G from respiratory syncytial virus.
The secretory glycoprotein (Gs) of respiratory syncytial virus (RSV) was enriched and investigated for its effects on T cells specific for RSV and unrelated antigens. Gs exhibited a dose dependent suppression of lymphoproliferative responses in peripheral blood mononuclear cells (PBMCs), specific for mycobacterial lysates or tetanus toxoid. However, Gs did not inhibit live RSV specific T cell responses. These results suggest that Gs may suppress immune response to unrelated antigens, but should not interfere with the overall development of RSV specific immunity.
Ray
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R
Division of Infectious Diseases and Immunology, Saint Louis University, 3635 Vista Avenue, St. Louis, MO 63110, USA. rayr@slu.edu
Hoft
D F
DF
Meyer
K
K
Brown
R
R
Lagging
L M
LM
Belshe
R B
RB
D000328:Adult; D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000276:immunology* / Q000378:metabolism*
D014764:Viral Proteins