title: In vitro hemodynamic evaluation of a Simon nitinol vena cava filter: possible explanation of IVC occlusion.
abstract: OBJECTIVE
  To evaluate the local hemodynamics in the region of the Simon nitinol filter (SNF), used to prevent pulmonary emboli by capturing clot and promoting lysis.
  
  
  METHODS
  The hemodynamics of the Simon nitinol inferior vena cava (IVC) filter were evaluated under steady flow (Re = 600) in a 20-mm-diameter IVC model. The photochromic dye tracer technique was used to estimate the velocity and wall shear stress. These flow features were determined for the unoccluded and partially occluded (clot volume = 1,500 mm(3)) states of the SNF along its center plane.
  
  
  RESULTS
  A region of low velocities developed around the central axis of the filter extending from the leading edge of the central strut to the filter tip. This phenomenon was created by the strong redirection of flow toward the periphery of the filter. With the presence of the clot, these effects were enhanced, causing flow separation and recirculation. In addition, the shear stress on the hip of the clot was about 30 times that of the upstream value, and turbulence developed in the near-downstream region.
  
  
  CONCLUSIONS
  The extended region of almost-stagnant flow near the midsection of the umbrella region could lead to organization of thrombus and fibrin mesh network development. The presence of a simulated clot led to a significant increase in the size of the stagnant, thrombus-prone region as well as turbulence, which, overall, may contribute to caval occlusion.
authors.affiliation: Institute of Biomaterials and Biomedical Engineering, University of Toronto, 4 Taddle Creek Road, Room 407, Toronto, Ontario, Canada M5S 3G9.
authors.forename: R L
authors.initials: RL
authors.lastname: Leask
authors.forename: K W
authors.initials: KW
authors.lastname: Johnston
authors.forename: M
authors.initials: M
authors.lastname: Ojha
mesh_terms: D000497:Alloys; D001783:Blood Flow Velocity; D006439:Hemodynamics / Q000502:physiology*; D008955:Models, Cardiovascular; D011475:Prosthesis Failure; D016306:Vena Cava Filters; D014682:Vena Cava, Inferior / Q000502:physiology*
chemical_list: D000497:Alloys; C013616:nitinol