Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur.
The structure of a tetragonal crystal form of thiostrepton has been solved using the anomalous dispersive effects of five S atoms from high-redundancy data collected to 1.33 A resolution at the Cu Kalpha wavelength. Data measured to 1.02 A resolution with a synchrotron source were used for refinement. Details of the molecular structure, intramolecular and intermolecular interactions are given.
Bond
C S
CS
The Wellcome Trust Biocentre, University of Dundee, Dundee DD1 5EH, Scotland, UK.
Shaw
M P
MP
Alphey
M S
MS
Hunter
W N
WN
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D003460:Crystallization; D008958:Models, Molecular; D011487:Protein Conformation; D013455:Sulfur / Q000737:chemistry*; D013883:Thiostrepton / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D013455:Sulfur; D013883:Thiostrepton