title: Walking ability as a measure of treatment effect in early rheumatoid arthritis.
abstract: OBJECTIVE
  To assess the clinical usefulness of a prototype walkmat system in patients with early rheumatoid arthritis (RA).
  
  
  METHODS
  Twenty-four subjects with early RA and symptomatic forefoot disease requiring therapy with second-line drugs were recruited.
  
  
  METHODS
  Each subject underwent clinical assessment together with gait analysis on the contact sensitive walkmat system and Kistler forceplate before and after six months of treatment with second-line drugs. Two subjects were lost to follow-up.
  
  
  RESULTS
  There was the expected improvement in disease activity in response to therapy. Significant differences were also demonstrated in defined gait parameters that indicated improved weight-bearing and enhanced forefoot propulsion.
  
  
  CONCLUSIONS
  Medical therapy improved walking ability in patients with RA and the walkmat system provided a useful adjunct to existing outcome measures in the assessment of lower limb function.
authors.affiliation: Southern General Hospital NHS Trust, Glasgow, Scotland, UK.
authors.forename: J
authors.initials: J
authors.lastname: Hamilton
authors.forename: G
authors.initials: G
authors.lastname: Brydson
authors.forename: S
authors.initials: S
authors.lastname: Fraser
authors.forename: M
authors.initials: M
authors.lastname: Grant
mesh_terms: D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology*; D005080:Exercise Test / Q000295:instrumentation / Q000379:methods* / Q000592:standards; D005260:Female; D005500:Follow-Up Studies; D005528:Foot / Q000503:physiopathology*; D005684:Gait; D018737:Hand Strength; D006801:Humans; D008297:Male; D008875:Middle Aged; D012720:Severity of Illness Index; D012775:Shoes; D016896:Treatment Outcome; D016138:Walking; D016474:Weight-Bearing
chemical_list: D018501:Antirheumatic Agents