Feline immunodeficiency virus cell entry.
The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found to utilize the chemokine receptor CXCR4, but not CCR5, as a cellular receptor. Zidovudine blocked formation of late viral replication products most effectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by FIV.
Frey
S C
SC
Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.
Hoover
E A
EA
Mullins
J I
JI
D000818:Animals; D002460:Cell Line; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000502:physiology; D011991:Receptors, Virus / Q000502:physiology; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology
D019718:Receptors, CXCR4; D011991:Receptors, Virus; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine