Toxic epidermal necrolysis in a patient with severe aplastic anemia treated with cyclosporin A and G-CSF.
Toxic epidermal necrolysis (TEN) and severe aplastic anemia (SAA) are rare nonpredictable side effects of several drugs. To our knowledge there are no reports on the coexistence of these two disorders. This study presents a 23 year-old man with TEN diagnosed 6 days after treatment with aminophenazone, paracetamol and phenoxymethylpenicillin. The resolution of the skin disorder was observed after few days of treatment with G-CSF and cyclosporin A. In contrast, SAA only partially responded to treatment with these agents.
Robak
E
E
Department of Hematology, Medical University of Łódź, ul.Pabianicka 62, 93-513 Łódź, Poland.
Robak
T
T
Góra-Tybor
J
J
Chojnowski
K
K
Strzelecka
B
B
Waszczykowska
E
E
Sysa-Jedrzejowska
A
A
D000082:Acetaminophen / Q000009:adverse effects; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects; D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000188:drug therapy* / Q000503:physiopathology; D016572:Cyclosporine / Q000627:therapeutic use*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010404:Penicillin V / Q000009:adverse effects; D010406:Penicillins / Q000009:adverse effects; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy* / Q000473:pathology
D018712:Analgesics, Non-Narcotic; D010406:Penicillins; D016179:Granulocyte Colony-Stimulating Factor; D000082:Acetaminophen; D016572:Cyclosporine; D010404:Penicillin V