An update on hypercoagulable disorders.
Venous thrombosis is a cause of considerable morbidity and is often responsible for chronic venous disorders that frequently lead to visits to dermatologists and others involved in wound healing. Over the past several years, many new causes of thrombophilia have been identified and have dramatically altered the approach to patients presenting with thrombosis. Newly described abnormalities associated with thrombophilia include the syndrome of activated protein C resistance, the prothrombin 20210A mutation, hyperhomocysteinemia, and elevated levels of coagulation factors VIII and XI. Clinicians can now frequently determine causes of thromboses that have previously been deemed idiopathic.
Federman
D G
DG
VA Connecticut HCS (11ACSL), 950 Campbell Ave, West Haven, CT 06516, USA. Federman.Daniel_G+@west-haven.va.gov
Kirsner
R S
RS
D020016:Activated Protein C Resistance / Q000097:blood / Q000209:etiology; D000925:Anticoagulants / Q000627:therapeutic use; D001778:Blood Coagulation Disorders / Q000097:blood / Q000188:drug therapy / Q000209:etiology; D003276:Contraceptives, Oral / Q000009:adverse effects; D005165:Factor V / Q000378:metabolism; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications; D009154:Mutation; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology; D011516:Prothrombin / Q000235:genetics; D012008:Recurrence; D012307:Risk Factors; D014859:Warfarin / Q000627:therapeutic use
D000925:Anticoagulants; D003276:Contraceptives, Oral; C095381:factor V Leiden; D014859:Warfarin; D005165:Factor V; D011516:Prothrombin