title: Low cord blood pneumococcal antibody concentrations predict more episodes of otitis media.
abstract: OBJECTIVE
  To determine if cord blood anticapsular polysaccharide pneumococcal IgG antibody concentration was related to the number of otitis media (OM) and acute OM episodes during the first year of life.
  
  
  METHODS
  Prospective study following infants from birth to 24 months.
  
  
  METHODS
  Health maintenance organization.
  
  
  METHODS
  The study population consisted of 415 infants whose mothers volunteered for the study during pregnancy. Cord blood samples were collected and infants were followed up for OM in the health maintenance organization. Ninety-seven percent of the infants were white, 49% male, 3% from households with annual incomes of less than $20 000, and 30% from households with annual incomes of more than $60 000.
  
  
  METHODS
  Number of physician-diagnosed OM episodes, including both OM with effusion and acute OM, and acute OM episodes from birth to 12 months.
  
  
  RESULTS
  With univariate analysis, low cord blood antibody concentrations against serotypes 3 and 19F predicted more acute OM episodes (P =.04 and P =.05, respectively), and low antibody concentrations against serotypes 19F and 23F predicted more OM episodes (P =.04 and P =.05, respectively) over the first year of life. With Poisson regression, which adjusted for variables related to the recurrence of OM and having low cord blood antibody concentrations, serotype 19F remained significantly related to the number of OM episodes (relative risk for lowest quartiles vs upper 3 quartiles 1.23; 95% confidence interval, 1.02-1.50; P =.03).
  
  
  CONCLUSIONS
  Low cord blood antibody concentrations to serotype 19F predicted more OM episodes over the first 12 months of life. These results suggest the potential benefit of maternal immunization to raise neonatal antipolysaccharide pneumococcal antibody concentration and delay the onset and reduce the number of OM episodes.
authors.affiliation: Otitis Media Research Center, MMC 396, University of Minnesota, Minneapolis 55455, USA.
authors.forename: E T
authors.initials: ET
authors.lastname: Becken
authors.forename: K A
authors.initials: KA
authors.lastname: Daly
authors.forename: B R
authors.initials: BR
authors.lastname: Lindgren
authors.forename: M H
authors.initials: MH
authors.lastname: Meland
authors.forename: G S
authors.initials: GS
authors.lastname: Giebink
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010033:Otitis Media / Q000175:diagnosis* / Q000276:immunology; D011247:Pregnancy; D011379:Prognosis; D011446:Prospective Studies; D013296:Streptococcus pneumoniae / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G