Molecular aspects of HLA class II alphabeta heterodimers associated with IDDM susceptibility and protection.
HLA-DQ alleles are strongly associated with IDDM susceptibility and protection. Studies assessing the molecular properties of HLA-DR, a HLA class II locus in linkage disequilibrium with HLA-DQ, have made substantial contributions toward elucidating the structure and function of HLA class II molecules. Reports on the molecular properties of HLA-DQ are now following and have revealed interesting observations regarding the stability of HLA-DQ alphabeta heterodimers. Future work is expected to provide an understanding of the mechanism by which HLA-DQ is associated with IDDM susceptibility and protection.
Ettinger
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Virginia Mason Research Center and Department of Immunology, University of Washington School of Medicine, Seattle 98195-7710, USA. ettinger@u.washington.edu
Nepom
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D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology* / Q000517:prevention & control; D019281:Dimerization; D004198:Disease Susceptibility / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans
D006683:HLA-DQ Antigens