title: Prospective randomized comparison of two preoperative skin preparation techniques in a developing world country.
abstract: Povidone-iodine (PI) is a scarce and expensive item for some hospitals in developing countries. This prospective, randomized study was performed at Baptist Medical Centre (BMCO) in Ogbomoso, Nigeria to determine if the use of PI for preoperative skin preparation would result in a lower postoperative wound infection rate and to identify other factors influencing the infection rate. Two hundred patients undergoing inguinal hernia repair were randomized to receive skin preparation with either: (1) locally available, inexpensive market soap and methylated spirit or (2) imported PI. The two groups were equally stratified. The overall postoperative wound infection rate was 5.5%, and there was no significant difference between the groups (5.1% vs. 5.9%). Factors that did not affect the infection rate included gender, age, type of anesthesia, type or duration of the operative procedure, and number of breaks in optimal technique. There were eight abscesses and three cases of cellulitis without suppuration diagnosed an average of 10 days postoperatively. Staphylococcus was the only bacterium identified on Gram stain or culture. The expense of procuring PI is not justified at BMCO. Available funds may better be used for preoperative antibiotics or for improvement in hospital infrastructure, which should result in fewer breaks in optimal operating room technique.
authors.affiliation: Department of Surgery, Division of Pediatric Surgery, University of Texas Southwestern Medical School, Children's Medical Center, 1935 Motor Street, Room H310, Dallas, Texas 75235, USA. dmeier@childmed.dallas.tx.us
authors.forename: D E
authors.initials: DE
authors.lastname: Meier
authors.forename: S K
authors.initials: SK
authors.lastname: Nkor
authors.forename: D
authors.initials: D
authors.lastname: Aasa
authors.forename: D A
authors.initials: DA
authors.lastname: OlaOlorun
authors.forename: J L
authors.initials: JL
authors.lastname: Tarpley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011206:Povidone-Iodine / Q000627:therapeutic use*; D011446:Prospective Studies; D012915:Soaps; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000891:Anti-Infective Agents, Local; D012915:Soaps; D011206:Povidone-Iodine