title: Evaluation of a global screening assay for the investigation of the protein C anticoagulant pathway.
abstract: We have evaluated a global screening test for the protein C pathway, the 'ProC Global' (Dade Behring Ltd, Milton Keynes, UK). Patient groups tested included inherited protein C or S deficient and inherited/acquired activated protein C resistance. Results showed that protein C deficiencies and activated protein C resistance could be successfully detected with this test whereas deficiencies of protein S were less readily distinguished from the normal population. The ProC Global was unreliable in patients with antiphospholipid antibodies, raised plasma factor VIII:C and in those receiving oral anticoagulant therapy.
authors.affiliation: Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK.
authors.forename: J E
authors.initials: JE
authors.lastname: Rimmer
authors.forename: P C
authors.initials: PC
authors.lastname: Cooper
authors.forename: C J
authors.initials: CJ
authors.lastname: Brookfield
authors.forename: F E
authors.initials: FE
authors.lastname: Preston
authors.forename: M
authors.initials: M
authors.lastname: Makris
mesh_terms: D020016:Activated Protein C Resistance / Q000097:blood / Q000175:diagnosis; D001780:Blood Coagulation Tests / Q000379:methods* / Q000592:standards; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008297:Male; D010314:Partial Thromboplastin Time; D011486:Protein C / Q000032:analysis* / Q000592:standards; D020151:Protein C Deficiency / Q000097:blood / Q000175:diagnosis; D012016:Reference Values; D012737:Sex Factors
chemical_list: D016682:Lupus Coagulation Inhibitor; D011486:Protein C