Angiogenic effects of suture biomaterials. An experimental study in rats.
Angiogenesis is a limiting step of inflammation and wound healing. Although laboratory tests for the evaluation of the angiogenetic effects of biomaterials are available, no investigations have been performed. In this study we examine the angiogenetic effect of suture biomaterials in the rat mesenteric window model. Absolute controls had laparotomy only, controls had mesenteric window wounding, test groups had the insertion of either a thread of collagen, polyglactin 910, polyglycolic acid salt, silk or of a titanium clip. We considered the percentage area of the mesenteric window covered by neovessels. After 7 days, negligible angiogenesis was found in absolute controls, significant angiogenesis in controls, collagen, polyglactin 910 and polyglycolic acid salt treated rats, without differences between treatments. A significant increase of angiogenesis in comparison to the control group was found in rats treated with silk and titanium. Ultramicroscopy of the neovessels showed specific changes of their architecture in titanium-treated rats. In conclusion, angiogenesis during wound healing is differently influenced by the suture material used. Silk and titanium stimulated angiogenesis in a different way.
Foschi
D
D
First Department of Surgery, Institute of Biomedical Sciences 'L. Sacco' and Wound Healing Centre, University of Milan, Italy.
Corsi
F
F
Cellerino
P
P
Rizzi
A
A
Morandi
E
E
Trabucchi
E
E
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001808:Blood Vessels / Q000473:pathology; D003094:Collagen / Q000494:pharmacology; D003250:Constriction; D019476:Insect Proteins / Q000494:pharmacology; D008297:Male; D008854:Microscopy, Electron; D018919:Neovascularization, Physiologic / Q000187:drug effects* / Q000502:physiology; D011098:Polyglactin 910 / Q000494:pharmacology; D011100:Polyglycolic Acid / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D047011:Silk; D013537:Sutures; D014025:Titanium / Q000494:pharmacology; D014945:Wound Healing / Q000502:physiology
D001672:Biocompatible Materials; D019476:Insect Proteins; D047011:Silk; D011100:Polyglycolic Acid; D011098:Polyglactin 910; D003094:Collagen; D014025:Titanium