title: Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease.
abstract: BACKGROUND
  Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease.
  
  
  METHODS
  TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17).
  
  
  RESULTS
  Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01).
  
  
  CONCLUSIONS
  The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation.
authors.affiliation: King George's Medical College, Lucknow, India.
authors.forename: P
authors.initials: P
authors.lastname: Srivastava
authors.forename: S
authors.initials: S
authors.lastname: Saxena
authors.forename: V K
authors.initials: VK
authors.lastname: Khanna
authors.forename: D
authors.initials: D
authors.lastname: Kumar
authors.forename: R
authors.initials: R
authors.lastname: Nath
authors.forename: P K
authors.initials: PK
authors.lastname: Seth
mesh_terms: D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008054:Lipid Peroxides / Q000097:blood; D012164:Retinal Diseases / Q000097:blood* / Q000150:complications / Q000473:pathology; D015861:Retinal Neovascularization / Q000097:blood / Q000209:etiology / Q000473:pathology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D014657:Vasculitis / Q000097:blood* / Q000150:complications / Q000473:pathology
chemical_list: D015415:Biomarkers; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances