title: Comparative insect developmental genetics: phenotypes without mutants.
abstract: The last decade has seen a dramatic increase in interest in the extent to which morphological evolution depends on changes in regulatory pathways. Insects provide a fertile ground for study because of their diversity and our high level of understanding of the genetic regulation of development in Drosophila melanogaster. However, comparable genetic approaches are presently possible in only a small number of non-Drosophilid insects. In a recent paper, Hughes and Kaufman have used a new methodology, RNA interference, in the milkweed bug, Oncopeltus fasciatus, to phenocopy the effects of mutations in Hox genes. RNA interference involves the injection of double-stranded RNA of the same sequence as the relevant mRNA resulting in a depletion of that transcript. Hughes and Kaufman focused on the gnathal segments, which elaborate specialized appendages important to feeding. Their results indicate that gnathal adaptations in this bug are correlated with changes in Hox gene functions and interactions.
authors.affiliation: Kansas State University, Manhattan, Kansas 66506-4901, USA. rdenell@ksu.edu
authors.forename: R
authors.initials: R
authors.lastname: Denell
authors.forename: T
authors.initials: T
authors.lastname: Shippy
mesh_terms: D000818:Animals; D005801:Genes, Homeobox; D017344:Genes, Insect; D007313:Insecta / Q000235:genetics* / Q000254:growth & development*; D009154:Mutation; D010641:Phenotype; D012313:RNA / Q000235:genetics
chemical_list: D012313:RNA