title: A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26.
abstract: In an attempt to identify susceptibility loci for bipolar affective disorder, we are currently conducting a systematic genome screen with highly polymorphic microsatellite markers at an average marker spacing of 10 cM in a series of 75 families, comprising 66 families from Germany, eight families from Israel, and one family from Italy. The families were ascertained through index cases with bipolar affective disorder. The distribution of diagnoses is as follows: 126 individuals with bipolar I disorder, 40 with bipolar II disorder, 14 with schizoaffective disorder of the bipolar type, 40 individuals with recurrent unipolar depression, 51 with a minor psychiatric diagnosis, and two individuals with a diagnosis of schizophrenia. One hundred and seventy-one individuals are unaffected. Here, we present results from chromosome 10. Linkage analyses using a total of 33 microsatellite markers with parametric and non-parametric methods provided evidence for linkage at chromosomal region 10q25--q26. The highest two-point LOD score (2.86, theta = 0.05) was obtained for D10S217 using a dominant genetic model and a broad definition of affection status. The GENEHUNTER program localized the putative susceptibility locus within a ca 15-cM interval between markers D10S1483 and D10S217 with a maximum NPL(all) score of 3.12 (P = 0.0013). Positive linkage findings that have been reported by two independent studies further support the hypothesis of a susceptibility gene for bipolar affective disorder on 10q25-q26.
authors.affiliation: Institute of Human Genetics, University of Bonn, Wilhelmstr 31, D-53111 Bonn, Germany. cichon@mailer.meb.uni-bonn.de
authors.forename: S
authors.initials: S
authors.lastname: Cichon
authors.forename: G
authors.initials: G
authors.lastname: Schmidt-Wolf
authors.forename: J
authors.initials: J
authors.lastname: Schumacher
authors.forename: D J
authors.initials: DJ
authors.lastname: Müller
authors.forename: M
authors.initials: M
authors.lastname: Hürter
authors.forename: T G
authors.initials: TG
authors.lastname: Schulze
authors.forename: M
authors.initials: M
authors.lastname: Albus
authors.forename: M
authors.initials: M
authors.lastname: Borrmann-Hassenbach
authors.forename: E
authors.initials: E
authors.lastname: Franzek
authors.forename: M
authors.initials: M
authors.lastname: Lanczik
authors.forename: J
authors.initials: J
authors.lastname: Fritze
authors.forename: R
authors.initials: R
authors.lastname: Kreiner
authors.forename: B
authors.initials: B
authors.lastname: Weigelt
authors.forename: J
authors.initials: J
authors.lastname: Minges
authors.forename: D
authors.initials: D
authors.lastname: Lichtermann
authors.forename: B
authors.initials: B
authors.lastname: Lerer
authors.forename: K
authors.initials: K
authors.lastname: Kanyas
authors.forename: K
authors.initials: K
authors.lastname: Strauch
authors.forename: C
authors.initials: C
authors.lastname: Windemuth
authors.forename: M P
authors.initials: MP
authors.lastname: Baur
authors.forename: T F
authors.initials: TF
authors.lastname: Wienker
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: M
authors.initials: M
authors.lastname: Rietschel
authors.forename: P
authors.initials: P
authors.lastname: Propping
authors.forename: M M
authors.initials: MM
authors.lastname: Nöthen
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D005192:Family Health; D020022:Genetic Predisposition to Disease; D006801:Humans; D018895:Microsatellite Repeats; D009679:Nuclear Family