Reinforcement of early long-term potentiation (early-LTP) in dentate gyrus by stimulation of the basolateral amygdala: heterosynaptic induction mechanisms of late-LTP.
The basolateral amygdala (BLA) can influence distinct learning and memory formation. Hippocampal long-term potentiation (LTP), the most prominent cellular model of memory formation, can be modulated by stimulation of the BLA in its induction and early maintenance. However, it is not known how the late maintenance of LTP beyond its initial phases might be affected. Behavioral stimuli have been shown to result in a reinforcement of a transient early-LTP into a lasting potentiation. Here we show that BLA stimulation mimics the behavioral effects on early-LTP in freely moving rats when the BLA is activated within a time window of 30 min before or after tetanization of the perforant path. The reinforcement of LTP was blocked by inhibitors of muscarinergic and beta-adrenergic but not dopaminergic receptors and was dependent on translation. Through these heterosynaptic associative interactions, hippocampal sensory information can be stabilized by amygdaloidal influences.
Frey
S
S
Leibniz-Institute for Neurobiology, Department of Neurophysiology, PF 1860, D-39008 Magdeburg, Germany. frey@ifn-magdeburg.de
Bergado-Rosado
J
J
Seidenbecher
T
T
Pape
H C
HC
Frey
J U
JU
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000679:Amygdala / Q000502:physiology*; D000818:Animals; D018891:Dentate Gyrus / Q000502:physiology*; D018492:Dopamine Antagonists / Q000494:pharmacology; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D018727:Muscarinic Antagonists / Q000494:pharmacology; D019580:Perforant Pathway / Q000502:physiology; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D009435:Synaptic Transmission / Q000502:physiology*; D014851:Wakefulness
D000319:Adrenergic beta-Antagonists; D018492:Dopamine Antagonists; D018691:Excitatory Amino Acid Antagonists; D018727:Muscarinic Antagonists; D011500:Protein Synthesis Inhibitors; D016194:Receptors, N-Methyl-D-Aspartate