title: Role of nitric oxide and lipid peroxidation in mechanisms of febrile convulsions in Wistar rat pups.
abstract: Generation of nitric oxide and the content of lipid peroxidation products in the brain are increased in rat pups during febrile convulsions. NO-synthase inhibitor N-nitro-L-arginine in a dose of 250 mg/kg prevented hyperthermia-induced accumulation of nitric oxide, increased the latency febrile convulsions, and had no effect on the content of lipid peroxidation products.
authors.affiliation: Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow. juliakl@mail.ru
authors.forename: Y A
authors.initials: YA
authors.lastname: Klyueva
authors.forename: V G
authors.initials: VG
authors.lastname: Bashkatova
authors.forename: G Y
authors.initials: GY
authors.lastname: Vitskova
authors.forename: V B
authors.initials: VB
authors.lastname: Narkevich
authors.forename: V D
authors.initials: VD
authors.lastname: Mikoyan
authors.forename: A F
authors.initials: AF
authors.lastname: Vanin
authors.forename: S A
authors.initials: SA
authors.lastname: Chepurnov
authors.forename: N E
authors.initials: NE
authors.lastname: Chepurnova
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015227:Lipid Peroxidation; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D003294:Seizures, Febrile / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
chemical_list: D004791:Enzyme Inhibitors; D017392:Thiobarbituric Acid Reactive Substances; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase