[Effects of taurine enhancement of synthesis of TxA2 and PGI2 in cultured intra-pulmonary arteriolar smooth muscle cells under acute hypoxia].
The results of the present study demonstrated that the concentrations of thromboxane B2 (TxB2a) and 6-keto-prostaglandin F1 alpha (6-keto-PGF1 alpha), and their ratio were significantly increased in the medium of intra-pulmonary arteriolar smooth muscle cells (PASMCs) under acute hypoxia. Under either normoxia or hypoxia the concentration of TxB2 was significantly decreased with addition of taurine, while that of 6-keto-PGF1 alpha was significantly increased. With the addition of indomethacin, however, under similar conditions, the concentrations of both TxB2 and 6-keto-PGF1 alpha were decreased. Furthermore, the effect of indomethacin on TxA2 and 6-keto-PGF1 alpha concentrations could be reversed by taurine.
Hu
D H
DH
Department of Physiology, First Military Medical University, Guangzhou 510515.
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D000818:Animals; D015687:Cell Hypoxia; D002478:Cells, Cultured; D007213:Indomethacin; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D011651:Pulmonary Artery / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits; D013654:Taurine / Q000494:pharmacology*; D013929:Thromboxane B2 / Q000096:biosynthesis*
D013654:Taurine; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D007213:Indomethacin