title: Transcranial magnetic stimulation and antidepressive drugs share similar cellular effects in rat hippocampus.
abstract: Transcranial magnetic stimulation (TMS) has been proposed as a safe and efficient treatment of human clinical depression. Although its antidepressive mechanism of action remained unknown, our previous studies indicate that TMS has a long-lasting effect on neuronal excitability in the hippocampus. We now compare the effects of chronic TMS with those of the antidepressant drugs desipramine and mianserin. The three treatments did not affect basal conduction in the perforant path to the dentate gyrus, but markedly suppressed paired-pulse and frequency-dependent inhibition, resulting from a reduction in local circuit inhibition in the dentate gyrus. Concomitantly, these treatments enhanced the expression of long-term potentiation in the perforant path synapse in the dentate gyrus. Finally, chronic TMS as well as mianserin suppressed the serotonin-dependent, potentiating action of fenfluramine on population spike in the dentate gyrus. Thus, TMS, mianserin, and desipramine are likely to affect the same neuronal populations, which may be relevant to their antidepressant action.
authors.affiliation: Department of Neurobiology, The Weizmann Institute, Rehovot, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Levkovitz
authors.forename: N
authors.initials: N
authors.lastname: Grisaru
authors.forename: M
authors.initials: M
authors.lastname: Segal
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003891:Desipramine / Q000494:pharmacology; D004558:Electric Stimulation; D004599:Electric Stimulation Therapy; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D005277:Fenfluramine / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D012701:Serotonin / Q000378:metabolism; D017367:Selective Serotonin Reuptake Inhibitors / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D050781:Transcranial Magnetic Stimulation / Q000627:therapeutic use
chemical_list: D018759:Adrenergic Uptake Inhibitors; D000317:Adrenergic alpha-Antagonists; D000928:Antidepressive Agents; D003891:Desipramine; D005277:Fenfluramine; D008803:Mianserin; D012701:Serotonin; D017367:Selective Serotonin Reuptake Inhibitors