The immuno-inflammatory reaction in Crohn's disease and ulcerative colitis: characterisation, genetics and clinical application. Focus on TNF alpha.
Inflammatory bowel diseases are multifactorial polygenic diseases. The author has worked on the characterisation of the mucosal immuno-inflammatory reaction, on genetic predisposition and on potential clinical application of blood immuno-inflammatory markers in these diseases. This paper summarizes some aspects of this work, focusing on TNF. Following points are developed: production of TNF by inflamed mucosa, genetic control of TNF production, TNF gene polymorphim in inflammatory bowel disease, and evaluation of serum TNF as a marker of disease activity or evolutivity.
Louis
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Department of Gastroenterology, CEMIC (Centre d'Etude des Maladies Inflammatoires Chroniques), and CTCM (Centre de Thérapie Cellulaire et Moléculaire), University Hospital of Liège, Belgium.
D015415:Biomarkers / Q000097:blood; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D003424:Crohn Disease / Q000175:diagnosis / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D011110:Polymorphism, Genetic; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics* / Q000378:metabolism
D015415:Biomarkers; D018836:Inflammation Mediators; D017472:Receptors, Interleukin-1; D014409:Tumor Necrosis Factor-alpha