Cloning and characterization of a novel human leptin receptor overlapping transcript-like 1 gene (LEPROTL1).
A new full-length cDNA encoding a novel protein was isolated from our human fetal brain cDNA library. The cDNA consists of 2701 bp and has a putative open reading frame encoding 131 amino acids which possesses a JAK binding site (Pro(46)-Ile-Pro(48) which is preceded by a cluster of hydrophobic residues) and is highly homologous to the leptin receptor gene-related protein (OB-RGRP). Northern blot analysis showed that this new gene is widely expressed in human tissues and radiation hybrid mapping placed the gene to human chromosome 8p21.1-8p21.2.
Huang
Y
Y
Institute of Genetics, School of Life Sciences, Fudan University, Shanghai 200433, China.
Ying
K
K
Xie
Y
Y
Zhou
Z
Z
Wang
W
W
Tang
R
R
Zhao
W
W
Zhao
S
S
Wu
H
H
Gu
S
S
Mao
Y
Y
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D002352:Carrier Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D002898:Chromosomes, Human, Pair 8; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000737:chemistry / Q000302:isolation & purification; D019143:Evolution, Molecular; D015723:Gene Library; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D020033:Protein Isoforms / Q000235:genetics; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin; D016415:Sequence Alignment; D017385:Sequence Homology
D002352:Carrier Proteins; D018076:DNA, Complementary; D047908:Intracellular Signaling Peptides and Proteins; C515448:LEPR protein, human; C107590:LEPROT protein, human; D020033:Protein Isoforms; D011956:Receptors, Cell Surface; D054411:Receptors, Leptin