title: Role of hepatitis E and other hepatotropic virus in aetiology of sporadic acute viral hepatitis: a hospital based study from urban Delhi.
abstract: Major hepatotropic virus continues to be an important cause of acute viral hepatitis (AVH) in developing countries like India. While epidemics of AVH have been well studied few serious sporadic cases from developing countries have been reviewed. We studied prospectively 75 cases of sporadic AVH who reported to our hospital and were evaluated for the presence of various hepatotropic viruses. The seroprevalence of IgG anti-HEV antibodies was studied in the general population as a control. We found 53.3% (40/75) of sporadic AVH cases were due to hepatitis E virus while 11% (8/75) were due to hepatitis B virus. Hepatitis C virus was responsible for 8% (6/75) of the sporadic AVH cases and hepatitis A was found in 5% (4/75) of the cases. No causative agent was found in 23% (17/75) of the sporadic AVH cases. The sporadic AVH cases due to HEV were not clinically or biochemically not different from AVH due to other viruses. We found a high prevalence of IgG anti-HEV in 35.6% (178/500) among the general population of urban Delhi. The study suggested that hepatitis E was the most common cause of sporadic AVH in urban Delhi. High seroprevalence of IgG anti-HEV antibodies in the general population and amongst the sporadic AVH cases suggests that it is unlikely to be protective antibody. IgM anti-HEV positive serology is considered diagnostic of acute hepatitis E infection in India, where hepatitis E is endemic.
authors.affiliation: Department of Medicine, Maulana Azad Medical College, New Delhi, 110002, India.
authors.forename: K
authors.initials: K
authors.lastname: Das
authors.forename: A
authors.initials: A
authors.lastname: Agarwal
authors.forename: R
authors.initials: R
authors.lastname: Andrew
authors.forename: G G
authors.initials: GG
authors.lastname: Frösner
authors.forename: P
authors.initials: P
authors.lastname: Kar
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002648:Child; D003906:Developing Countries; D004196:Disease Outbreaks; D019353:Endemic Diseases / Q000706:statistics & numerical data; D005260:Female; D006506:Hepatitis A / Q000453:epidemiology; D006508:Hepatitis Antibodies / Q000097:blood* / Q000276:immunology; D016751:Hepatitis E / Q000453:epidemiology; D016752:Hepatitis E virus / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000175:diagnosis / Q000453:epidemiology / Q000821:virology*; D006507:Hepatovirus / Q000276:immunology; D006761:Hospitals; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D011795:Surveys and Questionnaires
chemical_list: D006508:Hepatitis Antibodies; D007074:Immunoglobulin G