Clostridial constipation's broad pathology.
Clostridia are normally found in the healthy colon, where their numbers are kept in check by other bacteria. However, when they establish themselves in the ileum they become formidable foes. They produce medium-length fatty acids that increase water absorption, causing hypertension and drying up the feces, causing constipation.Furthermore, they can deconjugate bile (impaired fat absorption), metabolyze tryptophan (the most scarce of the essential amino acids), digest fiber (so that the more fiber the patient takes, the more the constipation is exacerbated), digest lecithin, produce carcinogenic metabolites and copious amounts of extremely foul smelling gas, etc. They can also prevent vitamin B12 absorption in the ileum, causing anemia. The synthetic sugar lactulose, which can only be digested by lactobacilli, can help displace the clostridia and resolve the constipation by causing the lactobacilli to produce short fatty acids that have the opposite effect to that of the medium fatty acids produced by clostridia and their accomplices: they cause water retention in the intestines.
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D050260:Carbohydrate Metabolism; D003013:Clostridium / Q000302:isolation & purification / Q000378:metabolism / Q000502:physiology*; D003106:Colon / Q000382:microbiology; D003248:Constipation / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology; D004044:Dietary Proteins / Q000378:metabolism; D006801:Humans; D007778:Lactobacillus / Q000302:isolation & purification / Q000502:physiology; D007792:Lactulose / Q000627:therapeutic use
D004044:Dietary Proteins; D007792:Lactulose