Time resolved optical tomography of the human forearm.
A 32-channel time-resolved optical imaging instrument has been developed principally to study functional parameters of the new-born infant brain. As a prelude to studies on infants, the device and image reconstruction methodology have been evaluated on the adult human forearm. Cross-sectional images were generated using time-resolved measurements of transmitted light at two wavelengths. All data were acquired using a fully automated computer-controlled protocol. Images representing the internal scattering and absorbing properties of the arm are presented, as well as images that reveal physiological changes during a simple finger flexion exercise. The results presented in this paper represent the first simultaneous tomographic reconstruction of the internal scattering and absorbing properties of a clinical subject using purely temporal data, with additional co-registered difference images showing repeatable absorption changes at two wavelengths in response to exercise.
Hillman
E M
EM
Department of Medical Physics and Bioengineering, University College London, UK.
Hebden
J C
JC
Schweiger
M
M
Dehghani
H
H
Schmidt
F E
FE
Delpy
D T
DT
Arridge
S R
SR
D000328:Adult; D001132:Arm / Q000000981:diagnostic imaging*; D002138:Calibration; D015444:Exercise; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008953:Models, Anatomic; D012542:Scattering, Radiation; D012984:Software; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*