Systolic dysfunction and blood pressure responses to supine exercise in patients with hypertrophic cardiomyopathy.
Left ventricular function and blood pressure responses were evaluated in 56 patients with non-obstructive hypertrophic cardiomyopathy (HCM) and 12 control subjects by using a radionuclide ventricular function monitor during supine ergometer exercise. Patients with HCM were divided into 2 groups: (i) group A had no decrease in ejection fraction (EF) during exercise; and (ii) group B had a decrease in EF during exercise. During exercise, the change in end-diastolic volume did not differ between the 3 groups. In contrast, the change in end-systolic volume differed between the 3 groups (p<0.0001). The change in systolic blood pressure (SBP) also differed significantly between the 3 groups. The change in SBP in group B was smaller than that in the control group and group A, and changes in the EF and changes in the SBP between rest and peak exercise showed a significant correlation (p<0.005). These results suggest that exercise-induced systolic dysfunction in patients with non-obstructive HCM may contribute to abnormal blood pressure response in those patients.
Shimizu
M
M
Second Department of Internal Medicine, School of Medicine, Kanazawa University, Japan. shimizu@med.kanazawa-u.ac.jp
Ino
H
H
Okeie
K
K
Yamaguchi
M
M
Nagata
M
M
Hayashi
K
K
Itoh
H
H
Iwaki
T
T
Oe
K
K
Konno
T
T
Taki
J
J
Mabuchi
H
H
D000328:Adult; D001794:Blood Pressure / Q000502:physiology*; D002302:Cardiac Output; D004452:Echocardiography; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D012146:Rest; D013318:Stroke Volume; D016683:Supine Position / Q000502:physiology*; D013599:Systole; D014655:Vascular Resistance; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology