title: Synthesis and structure-activity relationships of guanine analogues as phosphodiesterase 7 (PDE7) inhibitors.
abstract: The synthesis of a novel series of guanine analogues is reported. The compounds have been assessed in vitro and some analogues have been found to be inhibitors of phosphodiesterase type 7 (PDE7).
authors.affiliation: Celltech R & D, Granta Park, Great Abington, Cambridge, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Barnes
authors.forename: N
authors.initials: N
authors.lastname: Cooper
authors.forename: R J
authors.initials: RJ
authors.lastname: Davenport
authors.forename: H J
authors.initials: HJ
authors.lastname: Dyke
authors.forename: F P
authors.initials: FP
authors.lastname: Galleway
authors.forename: F C
authors.initials: FC
authors.lastname: Galvin
authors.forename: L
authors.initials: L
authors.lastname: Gowers
authors.forename: A F
authors.initials: AF
authors.lastname: Haughan
authors.forename: C
authors.initials: C
authors.lastname: Lowe
authors.forename: J W
authors.initials: JW
authors.lastname: Meissner
authors.forename: J G
authors.initials: JG
authors.lastname: Montana
authors.forename: T
authors.initials: T
authors.lastname: Morgan
authors.forename: C L
authors.initials: CL
authors.lastname: Picken
authors.forename: R J
authors.initials: RJ
authors.lastname: Watson
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000037:antagonists & inhibitors*; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D054708:Cyclic Nucleotide Phosphodiesterases, Type 7; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D006147:Guanine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D007527:Isoenzymes; D006147:Guanine; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054684:Cyclic Nucleotide Phosphodiesterases, Type 3; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D054708:Cyclic Nucleotide Phosphodiesterases, Type 7