title: Fine-needle aspiration biopsy allows early detection of acute rejection in children after renal transplantation.
abstract: analysis detected rejections often before clinical signs. Half of the patients had increased serum creatinine concentration and 38% had fever at the time of rejection diagnosis. Both signs were present in only 19% of the episodes. A decrease in urine output (>20%) was seen in a third of the episodes. The rejections responded well to oral methylprednisolone (3 mg/kg/day), and lymphoglobulins were needed in only 12% of the episodes. More than 90% of the rejections were completely reversible and no transplant was lost because of acute rejection.
  
  
  CONCLUSIONS
  The results indicate that FNAB is a safe and sensitive method for the diagnosis and follow-up of acute cellular rejection in pediatric recipients of different ages.
authors.affiliation: Hospital for Children and Adolescents, University of Helsinki, Pediatric Nephrology and Transplantation, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Their
authors.forename: E
authors.initials: E
authors.lastname: von Willebrand
authors.forename: E
authors.initials: E
authors.lastname: Taskinen
authors.forename: K
authors.initials: K
authors.lastname: Rönnholm
authors.forename: C
authors.initials: C
authors.lastname: Holmberg
authors.forename: H
authors.initials: H
authors.lastname: Jalanko
mesh_terms: D000293:Adolescent; D000367:Age Factors; D001707:Biopsy, Needle / Q000379:methods / Q000592:standards; D001831:Body Temperature; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005240:Feasibility Studies; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D014554:Urination / Q000502:physiology
chemical_list: D003404:Creatinine