title: Tumors are unique organs defined by abnormal signaling and context.
abstract: Many cancer investigations have focussed on the eradication of the cancer cell itself and in doing so, overlook the inherent complexity and heterogeneity of solid tumors. Here, we argue that, in many cases, it is the altered communication within the tumor, rather than mutations per se, that is the defining characteristic of cancer. As a result, tumorigenesis can be indirectly initiated by environmental or inherited factors that affect the stromal cells. We propose that anticancer research might be more effective if aimed at eradicating the cause of abnormality rather than just treating the end result.
authors.affiliation: Life Science Division, Lawrence Berkeley National Laboratory, University of California, Berkeley, CA 94720, USA.
authors.forename: D
authors.initials: D
authors.lastname: Radisky
authors.forename: C
authors.initials: C
authors.lastname: Hagios
authors.forename: M J
authors.initials: MJ
authors.lastname: Bissell
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002450:Cell Communication / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D000970:Antineoplastic Agents