Structure-function relationship of three triple-helical nucleic acids.
The nucleic acid triplexes poly d(T) x poly d(A) x poly d(T), poly (U) x poly (A) x poly (U), and poly (I) x poly (A) x poly (I) display a sort of continuity between each other. However, their morphologies present their own individuality which, considering those of their parent duplexes, are quite unexpected. This comparison helps to understand triplex structure-function relationship. While helical parameters are functions of the sugar pucker, low values of WC and Hoogsteen base-pair propellers is commonplace for triplexes and the Hoogsteen base-pair geometry monitors the effects of the interstrand phosphates charge-charge repulsion.
Giacometti
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Department of Environmental Science, Facoltà di Scienze MM.FF.NN., University Ca' Foscari of Venice, Venezia, Italy. giacomet@unive.it
D009690:Nucleic Acid Conformation; D011061:Poly A / Q000737:chemistry; D011069:Poly I / Q000737:chemistry; D011071:Poly T / Q000737:chemistry; D011072:Poly U / Q000737:chemistry; D011119:Polynucleotides / Q000737:chemistry*; D013329:Structure-Activity Relationship
D011119:Polynucleotides; D011061:Poly A; D011071:Poly T; C015465:poly(dA); D011069:Poly I; D011072:Poly U