Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma.
The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.
Mendlick
M R
MR
Departments of Pathology & Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.
Nelson
M
M
Pickering
D
D
Johansson
S L
SL
Seemayer
T A
TA
Neff
J R
JR
Vergara
G
G
Rosenthal
H
H
Bridge
J A
JA
D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002878:Chromosomes, Human, Pair 1; D002893:Chromosomes, Human, Pair 3; D002999:Clone Cells; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008113:Liver Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1