title: Endoscopy and surgery. A combined strategy for diagnosis and therapy of polyposis-cancer sequence in the colon.
abstract: BACKGROUND
  The aim of the paper is to evaluate retrospectively the series of patients affected by colon polyps and colon cancer to purpose a planned follow-up for patients who underwent colon polypectomy.
  
  
  METHODS
  Out of 198 patients affected by colon carcinoma, the authors describe 95 cases of previous, synchronous or metachronous polyps, with a global prevalence of 47.9%, and respectively of 13.6%, 16.6%, and 17.6%.
  
  
  RESULTS
  The evolutive sequence between colon polyp and carcinoma is shown through both clinical experience and experimental tests. The epidemiologic curve of adenoma rate precedes by five years the curve of carcinoma, and such is the average period of time for the transformation of an adenoma into invasive carcinoma. In clinical practice, it is frequent to note synchronous or metachronous polyps with respect to colon carcinoma. It is also possible to note carcinoma in patients with previous polypectomies.
  
  
  CONCLUSIONS
  On the basis of the retrospective evaluation of the clinical cases, and reviewing international literature, the authors suggest their diagnostic-therapeutic and endoscopic follow-up protocol for patients affected by colon neoformations (Fig. 1).
authors.affiliation: Chair of General Surgery, University of Milan, Milan, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Scorza
authors.forename: M
authors.initials: M
authors.lastname: De Monti
authors.forename: G
authors.initials: G
authors.lastname: Ghilardi
authors.forename: G
authors.initials: G
authors.lastname: Sgroi
authors.forename: E
authors.initials: E
authors.lastname: Kunkl
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000175:diagnosis* / Q000601:surgery*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002277:Carcinoma / Q000175:diagnosis* / Q000601:surgery*; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000601:surgery*; D004724:Endoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies