Pancreatic concentrations of cefepime.
The concentrations of cefepime in pancreatic pseudocyst fluid (n = 4), pancreatic tissue (n = 4) and pancreatic fistula fluid (n = 1), and simultaneous plasma concentrations, were measured after intravenous administration of a single 2 g dose to nine patients. Mean plasma concentration was 27.4 mg/L between 120 and 200 min after the end of infusion. Mean pancreatic cefepime concentration was 6.3 mg/L in pseudocyst and 10.7 mg/L in pancreatic tissue. Cefepime was detected by 30 min after the end of the perfusion in pancreatic fistulae fluid, and persisted at 8 h. We conclude that cefepime is a potentially useful antibiotic in prevention and treatment of pancreatic infection.
Delcenserie
R
R
Services d'Hépatogastroentérologie, Centre Hospitalo-Universitaire Nord, 80054 Amiens Cedex, France. delcenserie.richard@chu-amiens.fr
Dellion-Lozinguez
M P
MP
Yzet
T
T
Lepointe
B
B
Hary
L
L
Badoui
R
R
Verhaeghe
P
P
Andrejak
M
M
Dupas
J L
JL
D000328:Adult; D000368:Aged; D000077723:Cefepime; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000378:metabolism* / Q000517:prevention & control
D002511:Cephalosporins; D000077723:Cefepime