In vitro secretion of cytokines and prostaglandin-E2 by monocytes from lung cancer patients.
Monocytes (MO) from cancer patients present functional abnormalities, such as an altered secretion of soluble factors. In the present study, our aim was to evaluate the levels of interleukin-1beta (IL-1beta), tumour necrosis factor-alpha (TNF-alpha) and prostaglandin-E2 (PGE2) secreted in vitro by MO from lung cancer patients (LCP), spontaneously or after stimulation with lipopolysaccharide (LPS). Results showed that cytokine secretion was higher for MO from LCP than for MO from healthy controls, while in the 25% of the patients analysed, an absence of response to LPS treatment was found.
Trejo
Y G
YG
Laboratorio de Inmunología, Instituto de Biología y Medicina Experimental, Buenos Aires, Argentina.
Bordenave
R H
RH
Beviacqua
M
M
Rumi
L S
LS
D016022:Case-Control Studies; D002478:Cells, Cultured; D016207:Cytokines / Q000378:metabolism*; D015232:Dinoprostone / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D009000:Monocytes / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D007375:Interleukin-1; D008070:Lipopolysaccharides; D009363:Neoplasm Proteins; D014409:Tumor Necrosis Factor-alpha; D015232:Dinoprostone