Antimicrobial alkaloids from Zanthoxylum tetraspermum and caudatum.
Two benzophenanthrene alkaloids, 8-acetonyldihydronitidine and 8-acetonyldihydroavicine were isolated from Zanthoxylum tetraspermum stem bark along with liriodenine, sesamin, lichexanthone and (+)-piperitol-gamma,gamma-dimethylallylether. The species endemic to Sri Lanka, Z. caudatum, contained sesamin, savinin, liriodenine, decarine and 8-O-desmethyl-N-nornitidine. 8-Acetonyldihydronitidine and 8-acetonyldihydroavicine showed significant antibacterial activity while the former along with liriodenine was strongly antifungal. Savinin exhibited potent spermicidal activity. Both savinin and sesamin exhibited significant insecticidal activity.
Nissanka
A P
AP
Department of Chemistry, University of Peradeniya, Sri Lanka.
Karunaratne
V
V
Bandara
B M
BM
Kumar
V
V
Nakanishi
T
T
Nishi
M
M
Inada
A
A
Tillekeratne
L M
LM
Wijesundara
D S
DS
Gunatilaka
A A
AA
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification*; D010616:Phenanthrenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019685:Rosales / Q000737:chemistry*
C433025:8-acetonyldihydroavicine; C433024:8-acetonyldihydronitidine; D000470:Alkaloids; D000890:Anti-Infective Agents; D010616:Phenanthrenes