title: Three-dimensional MR imaging of mammographically detected suspicious microcalcifications.
abstract: BACKGROUND
  The purpose of this study was to evaluate the diagnostic value and clinical significance of three-dimensional MR imaging of the breast in patients with mammographically detected suspicious microcalcifications.
  
  
  METHODS
  Forty patients with suspicious microcalcifications on mammography were evaluated with three-dimensional MR imaging. MR findings were grouped mainly by distribution of abnormal enhancement (linear, focal-clumped, segmental-clumped, segmental-stippled and diffuse-stippled). These findings were compared with the mammography findings according to the criteria of the Breast Imaging Reporting and Data System (BI-RADS) and histopathologic data.
  
  
  RESULTS
  Twenty patients had proven malignancies, most frequently ductal carcinoma in situ. For all the cases, linear (100%) and segmental-clumped type (100%) enhancement on MR imaging showed a significantly higher risk for malignancy. Diffuse stippled type (7%) and no enhancement (0%) on MR imaging indicated the lowest possibility of malignancy. 3D-MR imaging showed a sensitivity of 90%, a specificity of 95% and an overall accuracy of 93% in this study.
  
  
  CONCLUSIONS
  Three-dimensional MR imaging of the breast can more accurately diagnose ductal carcinoma in situ. Combined with mammography, this procedure is useful for reducing the number of false-positive biopsies and helpful for deciding the better management of patients with mammographically detected suspicious microcalcifications.
authors.affiliation: Breastopia Namba Hospital, 2-112-1 Maruyama, Miyazaki, Miyazaki 880-0052, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakahara
authors.forename: K
authors.initials: K
authors.lastname: Namba
authors.forename: A
authors.initials: A
authors.lastname: Fukami
authors.forename: R
authors.initials: R
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Furusawa
authors.forename: T
authors.initials: T
authors.lastname: Matsu
authors.forename: F
authors.initials: F
authors.lastname: Akiyama
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: H
authors.initials: H
authors.lastname: Ifuku
authors.forename: M
authors.initials: M
authors.lastname: Nakahara
authors.forename: S
authors.initials: S
authors.lastname: Tamura
mesh_terms: D000328:Adult; D000368:Aged; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000175:diagnosis; D002114:Calcinosis / Q000175:diagnosis*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008327:Mammography; D008875:Middle Aged
chemical_list: D019786:Gadolinium DTPA