HLA alleles and susceptibility to dermatological disorders associated with Helicobacter pylori infection: a significant association to HLA-Cw*06.
The occurrence rate of HLA class I and class II alleles was established in 24 patients suffering from dermatological disorders associated with the Helicobacter pylori infection. The increased frequency of HLA-C*0602, 4 was found to be 0.1875 compared to 0.0733 in the control group (odds ratio: 2.913; two-sided P value: P = 0.0251). Our data suggest that the HLA-Cw6 molecule play a role in the susceptibility to the Helicobacter pylori infection.
Kulcsárová
E
E
Department of Immunology, Faculty of Medicine, Comenius University, Bratislava, Slovakia. kulcsarova@hotmail.com
Fazekasová
H
H
Královicová
J
J
Buc
M
M
Kolibásová
K
K
Hegyi
E
E
D000483:Alleles; D004247:DNA / Q000097:blood; D005756:Gastritis / Q000382:microbiology; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics*; D016481:Helicobacter Infections / Q000235:genetics / Q000276:immunology*; D016480:Helicobacter pylori; D006801:Humans; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D012016:Reference Values; D017192:Skin Diseases, Bacterial / Q000235:genetics / Q000276:immunology*
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; C528994:HLA-C*06 antigen; D004247:DNA