title: Immediate effects of endoscopic sphincterotomy on sphincter of Oddi motility.
abstract: The evidence exists that incomplete sphincterotomy in patients with biliary tract diseases may result in early symptoms reoccurrence or lack of improvement. Sphincter of Oddi manometry (SOM) can be used to verify the completeness of the procedure. The purpose of the study was to investigate the immediate effects of biliary endoscopic sphincterotomy (BES) and common bile duct stones (CBDS) clearance on biliary sphincter of Oddi (SO) motility. Moreover the percentage of incomplete sphincterotomies was estimated. 26 patients (6 male, 20 female, 24-93 years) with confirmed choledocholithiasis were investigated. All underwent BES followed by CBDS extraction, and then SO manometry (SOM) was performed. Moreover 6 patients underwent SOM prior to BES. SOM was performed with a triple lumen 5 Fr catheter attached to the water perfused low compliance system. Immediately after sphincterotomy and extraction of the CBDS common bile duct pressure dropped from a mean of 10.9 mmHg to 2.9 mmHg (p < 0.05). Similarly basal biliary sphincter pressure decreased from 22.7 mmHg to 7.3 mmHg (p < 0.05). 20 patients presented duodeno-choledochal gradient of less than 5 mmHg. However only 10 patients had also basal sphincter pressure lower than 5 mmHg. The phasic sphincter activity was abolished in 16 patients, whereas phasic contractions persisted in 10 patients. Seven patients displayed uncoordinated, low amplitude contractility. BES significantly decreases SO and CBD pressures, but when performed for CBDS extraction, commonly does not abolish SO motor activity nor ablate choledocho-duodenal gradient. Therefore to confirm the completeness of sphincterotomy, SO manometry is recommended.
authors.affiliation: Department of Pathophysiology Collegium Medicum Jagiellonian University ul. Czysta 18, 21-121 Cracow. ulablaut@yahoo.com
authors.forename: U
authors.initials: U
authors.lastname: Błaut
authors.forename: J
authors.initials: J
authors.lastname: Marecik
authors.forename: J
authors.initials: J
authors.lastname: Gniady
authors.forename: J
authors.initials: J
authors.lastname: Laskiewicz
authors.forename: P J
authors.initials: PJ
authors.lastname: Thor
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002758:Cholangiography; D003135:Common Bile Duct / Q000503:physiopathology*; D004384:Duodenoscopy; D005260:Female; D042882:Gallstones / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011312:Pressure; D009803:Sphincter of Oddi / Q000503:physiopathology*; D016717:Sphincterotomy, Endoscopic