Increased taurine content in esophageal mucosa of children affected by gastroesophageal reflux.
We studied the possible involvement of mucosal amino acid metabolism in the pathogenesis of gastroesophageal reflux disease in children. Eighteen children with gastroesophageal reflux disease (8 with reflux esophagitis and 10 without) and 10 children with normal 24-h esophageal pH monitoring as a comparative group underwent esophagogastroduodenoscopy with biopsies. Plasma and esophageal mucosa amino acids were assayed by liquid chromatography. In children affected by gastroesophageal reflux disease we found an increase of mucosal taurine (P < 0.01) and a decrease of serine (P < 0.01). No differences were noted between patients with and without esophagitis. Significant positive correlations (P < 0.001; r = 0.626) were found between mucosal taurine content and reflux index. Plasma amino acid concentrations did not show any significant differences among groups. Our results indicate that biochemical alterations precede the histological findings of inflammation, likely reflecting the adaptive response of the esophageal mucosa to the gastric contents exposure.
D'Eufemia
P
P
Institute of Paediatrics, University La Sapienza, Rome, Italy.
Corrado
G
G
Finocchiaro
R
R
Celli
M
M
Cavaliere
M
M
Troiani
P
P
Tote
J
J
Cardi
E
E
Giardini
O
O
D000293:Adolescent; D000596:Amino Acids / Q000032:analysis / Q000378:metabolism; D002648:Child; D004947:Esophagus / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D005764:Gastroesophageal Reflux / Q000378:metabolism*; D006801:Humans; D008297:Male; D009092:Mucous Membrane / Q000737:chemistry / Q000378:metabolism; D013654:Taurine / Q000032:analysis* / Q000378:metabolism
D000596:Amino Acids; D013654:Taurine