Is antigen presentation the primary function of HLA-G?
Human histocompatibility leukocyte antigen (HLA)-G is an antigen-presenting molecule. This review discusses the possibility that this might not be its primary function. HLA-G indeed modulates innate immunity by interacting with immunoglobulin-like receptors and by regulating HLA-E expression and its subsequent interaction with CD94/NKG2 receptors. HLA-G also down-modulates both CD8(+) and CD4(+) T-cell responsiveness.
Le Bouteiller
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Inserm U 395, CHU Purpan, BP 3028, 31024 Toulouse cedex 3, France. phil.lb@purpan.inserm.fr
Solier
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D000483:Alleles; D017951:Antigen Presentation; D005260:Female; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007110:Immunity, Active; D007113:Immunity, Innate; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D016693:Receptors, Antigen, T-Cell, alpha-beta