title: Intimin and the host cell--is it bound to end in Tir(s)?
abstract: Intimate bacterial adhesion to the intestinal epithelium is a pathogenic mechanism shared by several human and animal enteric pathogens, including enteropathogenic and enterohaemorrhagic Escherichia coli. Two bacterial protein partners involved in this intimate association have been identified, intimin and Tir. Some key remaining questions include whether intimin specifically interacts with one or more host-cell-encoded molecules and whether these contacts are a prerequisite for the subsequent intimate intimin-Tir association. Recent data support the hypothesis that the formation of a stable intimin-Tir relationship is the consequence of intimin protein interactions involving both host and bacterial components.
authors.affiliation: Centre for Molecular Microbiology and Infection, Dept. of Biochemistry, Imperial College of Science, Technology and Medicine, SW7 2AZ, London, UK. g.frankel@ic.ac.uk
authors.forename: G
authors.initials: G
authors.lastname: Frankel
authors.forename: A D
authors.initials: AD
authors.lastname: Phillips
authors.forename: L R
authors.initials: LR
authors.lastname: Trabulsi
authors.forename: S
authors.initials: S
authors.lastname: Knutton
authors.forename: G
authors.initials: G
authors.lastname: Dougan
authors.forename: S
authors.initials: S
authors.lastname: Matthews
mesh_terms: D018829:Adhesins, Bacterial; D000818:Animals; D001422:Bacterial Adhesion; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry / Q000378:metabolism*; D001426:Bacterial Proteins / Q000378:metabolism*; D002352:Carrier Proteins; D002478:Cells, Cultured; D004848:Epithelium / Q000378:metabolism / Q000382:microbiology; D004926:Escherichia coli / Q000502:physiology*; D029968:Escherichia coli Proteins; D006801:Humans; D016253:Microscopy, Immunoelectron; D011485:Protein Binding; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*
chemical_list: D018829:Adhesins, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D011956:Receptors, Cell Surface; C109287:Tir protein, E coli; C073819:eaeA protein, E coli