title: Intact insulin, insulin propeptides, and intima-media thickness in the femoral artery in 58-year-old clinical healthy men--the Atherosclerosis and Insulin Resistance Study.
abstract: The aim of this study was to examine the association between intact insulin, insulin propeptides, and femoral artery intima-media thickness. The design was a cross-sectional study and the study group (n = 391) consisted of randomly recruited clinically healthy 58-year-old Swedish men. The intima-media thickness of the common femoral artery was measured with ultrasound. Fasting plasma insulin; intact insulin; proinsulin; 32,33 split-proinsulin; and C-peptide concentrations were assessed. The results showed that the common femoral artery intima-media thickness correlated significantly and univariately with waist-hip ratio, systolic blood pressure, serum total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, ApoB, low-density lipoprotein peak particle size, and cigarette years. Furthermore, of intact insulin and insulin propeptides, only intact insulin and C-peptide were univariately associated with common femoral artery intima-media thickness (r= 0.14, p < 0.01; r= 0.18, p < 0.01; respectively). In a multiple regression analysis, common femoral artery intima-media thickness was independently associated with systolic blood pressure (beta-coefficient = 0.004, p = 0.002), ApoB (beta-coefficient = 0.338, p < 0.001 ) and cigarette years (beta-coefficient = 0.0004, p < 0.001), (R2= 25%, p<O0.00). In conclusion, smoking, systolic blood pressure, and ApoB but not insulin or insulin propeptides were independently associated with femoral atherosclerosis.
authors.affiliation: Department of Medicine, Sahlgrenska University Hospital, Göteborg University, Sweden. lena.bokemark@wlab.wall.gu.se
authors.forename: L
authors.initials: L
authors.lastname: Bokemark
authors.forename: J
authors.initials: J
authors.lastname: Wikstrand
authors.forename: B
authors.initials: B
authors.lastname: Fagerberg
mesh_terms: D001055:Apolipoproteins B / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000503:physiopathology; D015415:Biomarkers / Q000097:blood; D001794:Blood Pressure; D002096:C-Peptide / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005263:Femoral Artery / Q000000981:diagnostic imaging*; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D008875:Middle Aged; D011384:Proinsulin / Q000097:blood; D011498:Protein Precursors / Q000097:blood; D011863:Radioimmunoassay; D012016:Reference Values; D012307:Risk Factors; D014280:Triglycerides / Q000097:blood; D017539:Tunica Intima / Q000000981:diagnostic imaging*; D014463:Ultrasonography
chemical_list: D001055:Apolipoproteins B; D015415:Biomarkers; D002096:C-Peptide; D007328:Insulin; D011498:Protein Precursors; D014280:Triglycerides; C070703:proinsulin, des(31,32)-; D011384:Proinsulin; D002784:Cholesterol