Physical stabilization of DNA-based therapeutics.
The development of non-viral vectors for gene delivery has primarily focused on improving the efficiency of gene transfer in vivo. Although there is clearly a need to improve delivery efficiency, studies also indicate that the physical stability of non-viral vectors is not nearly adequate for a marketable pharmaceutical product. Here, we describe the different strategies that have been used to enhance stability and discuss the mechanisms by which prolonged stabilization (>2 years) might be achieved.
Anchordoquy
T J.
TJ
School of Pharmacy, University of Colorado, 80262, Denver, CO, USA
Allison
S D.
SD
Molina
M d.C.
MC
Girouard
L G.
LG
Carson
T K.
TK