title: Auditory brainstem response and temporal bone pathology findings in a brain-dead infant.
abstract: The criteria for assessing adult brain death have been already established, but those for infant brain death have not been yet established in Japan. We report auditory brainstem response (ABR) and postmortem pathology of the temporal bone and brain of a brain-dead 9-month-old female. During the comatose state, her ABR showed only waves I and II bilaterally. Autopsy revealed the presence of a left cerebellar astrocytoma, herniation and anoxic encephalopathy. The pathological examination of the temporal bone revealed the destruction of the inner ear particularly on the left side. In the auditory pathway of brain-dead patients, degeneration occurs first in the cerebrum, followed by the cochlear nerve. Thus, ABR is one of the useful means to assess brain death even in infants.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, Japan. IZT01356@nifty.ne.jp
authors.forename: M
authors.initials: M
authors.lastname: Ushio
authors.forename: K
authors.initials: K
authors.lastname: Kaga
authors.forename: H
authors.initials: H
authors.lastname: Sakata
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
authors.forename: Y
authors.initials: Y
authors.lastname: Makiyama
authors.forename: H
authors.initials: H
authors.lastname: Nishimoto
mesh_terms: D001254:Astrocytoma / Q000473:pathology / Q000503:physiopathology; D001926:Brain Death / Q000175:diagnosis / Q000473:pathology; D002526:Cerebellar Diseases / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000473:pathology / Q000503:physiopathology; D003128:Coma / Q000503:physiopathology; D007758:Ear, Inner / Q000473:pathology*; D004677:Encephalocele / Q000473:pathology; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D006801:Humans; D007223:Infant; D013701:Temporal Bone / Q000473:pathology*