[Thermodynamic approach to the selection of polyuronide sequestrants for the protection of the human body from toxic metal ions. Interactions of polyuronides with strontium and calcium ions].
Selectivity of polyuronide sequestrants (pectate, alginates of various uronide composition) in respect to Sr2+ and Ca2+ ions has been evaluated in terms of thermodynamic affinity. It is suggested that there is no point in the use of pectate as a Sr(2+)-binding agent because at initial stages of reaction it reveals higher affinity to Ca2+ ions in comparison to Sr2+ ions. Contrary to pectate, alginates under similar conditions have higher affinity to Sr2+ ions. It is shown that these ions are bound only by blocks of L-guluronic acid residues in alginate macromolecules. The results obtained lend support to the advisability of the use of alginate preparations with the high content of L-guluronic acid residues for the excretion of Sr2+ ions from human body.
Braudo
E E
EE
Danilova
I V
IV
Dianova
V T
VT
Kobak
V V
VV
Plashchina
I G
IG
D000464:Alginates; D002118:Calcium / Q000378:metabolism / Q000633:toxicity*; D002614:Chelating Agents; D006801:Humans; D008024:Ligands; D046911:Macromolecular Substances; D008673:Metals, Alkaline Earth / Q000378:metabolism / Q000633:toxicity*; D008962:Models, Theoretical; D010368:Pectins; D013053:Spectrophotometry; D013324:Strontium / Q000378:metabolism / Q000633:toxicity*; D013816:Thermodynamics; D014574:Uronic Acids; D015262:Xenobiotics / Q000633:toxicity
D000464:Alginates; D002614:Chelating Agents; D008024:Ligands; D046911:Macromolecular Substances; D008673:Metals, Alkaline Earth; D014574:Uronic Acids; D015262:Xenobiotics; C018402:traumacel; D010368:Pectins; D002118:Calcium; C003181:polygalacturonic acid; D013324:Strontium