Simulation of EMG in pathological situations.
OBJECTIVE
A mathematical model for simulation of the EMG from a muscle with its motor units is used. The study aims at correlating EMG findings (single-fiber EMG and concentric-needle EMG) with various induced morphological changes.


METHODS
Reinnervation has been simulated by removing motor units randomly followed by a complete reinnervation from adjacent surviving motor units. Fibre type grouping and grouped atrophy can be seen. Myopathy is simulated by increased fibre diameter variation, loss of fibres and muscle fibre splitting.


CONCLUSIONS
The simulation gives quantitative aspects of the importance of each of these factors. It indicates the relative sensitivity of various EMG parameters. The model can be used both for education and for research.
Stålberg
E
E
Department of Clinical Neurophysiology, University Hospital, SE-751 85, Uppsala, Sweden. erik.stalberg@nc.uas.lul.se
Karlsson
L
L
D000200:Action Potentials; D001369:Axons / Q000502:physiology; D004576:Electromyography / Q000295:instrumentation / Q000379:methods*; D006801:Humans; D008959:Models, Neurological; D008962:Models, Theoretical; D009045:Motor Endplate / Q000503:physiopathology; D009046:Motor Neurons / Q000502:physiology; D009121:Muscle Denervation; D018485:Muscle Fibers, Skeletal / Q000502:physiology*; D018482:Muscle, Skeletal / Q000294:innervation*; D009135:Muscular Diseases / Q000503:physiopathology*; D009468:Neuromuscular Diseases / Q000503:physiopathology*