title: Interactions among structural proteins of varicella zoster virus.
abstract: Varicella zoster virus tegument components include the regulatory proteins IE4, IE62, IE63 and the ORFI0 protein, a protein kinase (ORF47) and an abundant protein encoded in ORF9 which is the homolog of HSV VP22. The kinase is able to phosphorylate IE62 and the ORF9 protein specifically in viral particles. We show that interactions among these proteins are, at least in part, dependent on the presence or absence of phosphate groups and we suggest models for tegument formation and for its dissolution in the infected cell.
authors.affiliation: Department of Microbiology and Witebsky Center for Microbial Pathogenesis and Immunology State University of New York at Buffalo, 14214, USA.
authors.forename: M
authors.initials: M
authors.lastname: Spengler
authors.forename: N
authors.initials: N
authors.lastname: Niesen
authors.forename: C
authors.initials: C
authors.lastname: Grose
authors.forename: W T
authors.initials: WT
authors.lastname: Ruyechan
authors.forename: J
authors.initials: J
authors.lastname: Hay
mesh_terms: D000818:Animals; D014645:Herpesvirus 3, Human / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D017874:Immediate-Early Proteins / Q000235:genetics / Q000378:metabolism*; D011817:Rabbits; D015534:Trans-Activators / Q000235:genetics / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014759:Viral Envelope Proteins / Q000235:genetics / Q000378:metabolism*; D014764:Viral Proteins; D015678:Viral Structural Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: C074221:IE62 protein, Human herpesvirus 3; D017874:Immediate-Early Proteins; C085824:ORF4 protein, Human herpesvirus 3; D015534:Trans-Activators; D014759:Viral Envelope Proteins; D014764:Viral Proteins; D015678:Viral Structural Proteins; C074551:immediate early protein 63, Human herpesvirus 3