[Chronic myelogenous leukemia with marked thrombocytosis].
We report a case of chronic myelogenous leukemia (CML) with marked thrombocytosis. The patient was a 68-year-old woman who showed marked thrombocytosis (> 200 x 10(4)/microliter), a slightly increased leukocyte count without any immature myeloid cells in the peripheral blood, and no hepatosplenomegaly. Philadelphia chromosome (Ph) was detected by karyotype analysis and FISH. The bcr-abl transcript was detected by RT-PCR and the break point was located in the major bcr. Treatment with interferon-alpha was effective, reducing the proportion of Ph-positive cells from 56% to 7% within 21 months. Detailed study of atypical cases of CML such as the present one may provide additional information about the disease pathogenesis.
Hasegawa
T
T
Department of Physiology, Osaka City University Medical School.
Hino
M
M
Yamane
T
T
Ota
K
K
Takubo
T
T
Kitagawa
S
S
Tatsumi
N
N
D000368:Aged; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D013922:Thrombocytosis / Q000209:etiology*
D016898:Interferon-alpha; D016044:Fusion Proteins, bcr-abl