title: The treatment of choroidal melanoma with 198 Au plaque brachytherapy.
abstract: BACKGROUND
  Seventy-nine consecutive patients with primary choroidal melanoma were treated with 198 Au plaque brachytherapy at the British Columbia Cancer Agency (BCCA) between 1992 and 1998 with perioperative ultrasound to confirm plaque placement. Seventy-seven of the 79 patients were analyzable for this study.
  
  
  RESULTS
  Five year actuarial disease specific survival, enucleation free survival, and local control are 95, 94, and 98%, respectively. There were four melanoma related deaths, all secondary to liver metastases.
  
  
  CONCLUSIONS
  The BCCA experience in selected patients with choroidal melanomas treated with 198Au plaque brachytherapy has resulted in excellent survival and local control with minimal significant toxicity while preserving the globe. Our results using 198 Au seeds are comparable to other series using 125I, 60Co, and 106Ru at other centers.
authors.affiliation: British Columbia Cancer Agency, Vancouver Cancer Centre, 600 West 10th Avenue, B.C., V5Z 4E6, Vancouver, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Karvat
authors.forename: C
authors.initials: C
authors.lastname: Duzenli
authors.forename: R
authors.initials: R
authors.lastname: Ma
authors.forename: K
authors.initials: K
authors.lastname: Paton
authors.forename: T
authors.initials: T
authors.lastname: Pickles
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy / Q000009:adverse effects; D002830:Choroid Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D006050:Gold Radioisotopes / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D012189:Retrospective Studies; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D006050:Gold Radioisotopes