title: Diagnosis of concurrent hemoglobin H disease and heterozygous beta-thalassemia.
abstract: Definitive diagnosis of concurrent hemoglobin (Hb) H disease and heterozygous beta-thalassemia cannot be made from Hb analysis alone, but necessitates genotype analysis and family study. Interactions between alpha- and beta-thalassemia must be considered when investigating moderate to severe hypochromic microcytic anemia of uncertain cause in adult patients from areas with a high prevalence of globin gene mutations.
authors.forename: E S
authors.initials: ES
authors.lastname: Ma
authors.forename: A Y
authors.initials: AY
authors.lastname: Chan
authors.forename: W Y
authors.initials: WY
authors.lastname: Au
authors.forename: Y M
authors.initials: YM
authors.lastname: Yeung
authors.forename: L C
authors.initials: LC
authors.lastname: Chan
mesh_terms: D000328:Adult; D000747:Anemia, Hypochromic / Q000209:etiology; D004252:DNA Mutational Analysis; D005260:Female; D005914:Globins / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D009154:Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D017085:alpha-Thalassemia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D017086:beta-Thalassemia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics
chemical_list: D005914:Globins