[Allergies to ketoprofen gels].
A COMMON OBSERVATION: Ketoprofene gels, widely used to treat benign conditions, can provoke local intolerance. The most commonly reported clinical features include eczema, sometimes severe acute contact photoallergy that often spread beyond the site of application and may even lead to a long-duration generalized reaction.


METHODS
Photoallergological tests allow positive diagnosis of the ketoprofene-induced contact photosensitization and underline the role of the benzophenone ring, explaining certain cross allergies with fenofibrate and oxybenzone.
The primary rule is to avoid sun exposure, requiring better information for prescribers and patients.
Milpied-Homsi
B
B
Clinique Dermatologique, Hôtel-Dieu, place Alexis Ricordeau, F 44035 Nantes.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis / Q000209:etiology*; D017454:Dermatitis, Photoallergic / Q000175:diagnosis / Q000209:etiology; D003875:Drug Eruptions / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D005782:Gels / Q000009:adverse effects; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D010787:Photosensitivity Disorders / Q000150:complications* / Q000175:diagnosis / Q000517:prevention & control; D012882:Skin Tests; D013997:Time Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal; D005782:Gels; D007660:Ketoprofen