title: Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.
abstract: A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.
authors.affiliation: Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, Florida 34946, USA.
authors.forename: K B
authors.initials: KB
authors.lastname: Killday
authors.forename: D
authors.initials: D
authors.lastname: Yarwood
authors.forename: M A
authors.initials: MA
authors.lastname: Sills
authors.forename: P T
authors.initials: PT
authors.lastname: Murphy
authors.forename: J N
authors.initials: JN
authors.lastname: Hooper
authors.forename: A E
authors.initials: AE
authors.lastname: Wright
mesh_terms: D000818:Animals; D016203:CDC2 Protein Kinase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011687:Purines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
chemical_list: D004791:Enzyme Inhibitors; D011687:Purines; C430185:microxine; D016203:CDC2 Protein Kinase