Update in the pharmacological management of peptic ulcer haemorrhage.
The management of peptic ulcer haemorrhage still poses questions and controversies and this applies to the pharmacological mode. This review suggests that high-dose acid suppression is beneficial in reducing rebleeding and surgery rates. The choice of acid suppressant is far from conclusive, but emerging evidence suggests that proton pump inhibitors may be more effective than H2-antagonists. The only other drug which may be useful in selected patients is octreotide, but its universal use cannot be recommended.
Kubba
A K
AK
Dept. of Surgery and Gastroenterology, University of Nottingham, UK. ak.kubba@virgin.net
Selby
N M
NM
Hawkey
C J
CJ
D000897:Anti-Ulcer Agents / Q000008:administration & dosage*; D004381:Duodenal Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D004384:Duodenoscopy; D005260:Female; D005773:Gastroscopy; D006801:Humans; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D011379:Prognosis; D016032:Randomized Controlled Trials as Topic; D013276:Stomach Ulcer / Q000175:diagnosis / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate; D016896:Treatment Outcome; D006113:United Kingdom / Q000453:epidemiology
D000897:Anti-Ulcer Agents