title: Liquid ventilation in an infant with persistent interstitial pulmonary emphysema.
abstract: We present the case of a full term infant affected by diffuse persistent interstitial pulmonary emphysema (PIPE), who was treated with partial liquid ventilation (PLV) after the failure of conventional management. PIPE is a lethal chronic lung disease of unclear pathogenesis. Clinical history, radiological and histological findings confirmed the diagnosis in our patient. PLV applied for 48 hours resulted in a significant improvement in the infant's respiratory function and was not associated with adverse effects. We concluded that PLV could be effective in prolonging the survival of infants with PIPE; its application represents an effective form of respiratory support in infants with chronic lung disease.
authors.affiliation: Division of Neonatology, Careggi University Hospital, Florence, Italy. cdani@unifi.it
authors.forename: C
authors.initials: C
authors.lastname: Dani
authors.forename: M F
authors.initials: MF
authors.lastname: Reali
authors.forename: G
authors.initials: G
authors.lastname: Bertini
authors.forename: E
authors.initials: E
authors.lastname: Martelli
authors.forename: F F
authors.initials: FF
authors.lastname: Rubaltelli
mesh_terms: D000328:Adult; D001706:Biopsy; D002245:Carbon Dioxide / Q000097:blood; D017809:Fatal Outcome; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D021061:Liquid Ventilation; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration; D011247:Pregnancy; D011656:Pulmonary Emphysema / Q000473:pathology / Q000601:surgery / Q000628:therapy*; D011663:Pulmonary Surfactants / Q000627:therapeutic use; D012121:Respiration, Artificial
chemical_list: D011663:Pulmonary Surfactants; D002245:Carbon Dioxide; D009569:Nitric Oxide; D010100:Oxygen