Cryptofolione derivatives from Cryptocarya alba fruits.
Cryptofolione (1) and the new cryptofolione derivative 6-(4,6-dimethoxy-8-phenyl-octa-1,7-dienyl)-4-hydroxy-tetrahydro-pyran-2-one (2) were isolated from the fruits of Cryptocarya alba. The structures were elucidated by spectroscopic methods. Cryptofolione showed activity towards Trypanosoma cruzi trypomastigotes, reducing their number by 77% at 250 microg mL(-1). Cryptofolione showed moderate cytotoxicity in both macrophages and T. cruzi amastigotes. It also displayed a mild inhibitory effect on the promastigote form of Leishmania spp. As both cytotoxic and trypanocidal effects are similar, the compound presented little selectivity in our assay models.
Schmeda-Hirschmann
G
G
Instituto de Química de Recursos Naturales, Universidad de Talca, Chile. schmeda@pehuenche.utalca.cl
Astudillo
L
L
Bastida
J
J
Codina
C
C
Rojas De Arias
A
A
Ferreira
M E
ME
Inchaustti
A
A
Yaluff
G
G
D000818:Animals; D000977:Antiparasitic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001681:Biological Assay; D005638:Fruit / Q000737:chemistry; D007891:Leishmania / Q000187:drug effects; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology; D010945:Plants, Edible / Q000737:chemistry*; D011753:Pyrones / Q000302:isolation & purification* / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects
D000977:Antiparasitic Agents; D010936:Plant Extracts; D011753:Pyrones