Correlation between family history of hypertension and haemostatic disorders.
BACKGROUND
The aim of this study was to evaluate whether a family history of hypertension is associated with haemostatic disorders.


METHODS
In 38 normotensive subjects with a family history of hypertension (relatives) and in 46 sex, age and body mass index matched controls with no family history of hypertension, tissue-type plasminogen activator (t-PA), plasminogen activator-inhibitor (PAI-1), D-dimer (DD) and prothrombin fragment 1+2 (F1+2) were evaluated.


RESULTS
The t-PA and PAI-1 observed values were significantly higher than the values detected in the controls.


CONCLUSIONS
These data seem to suggest a correlation between family history of hypertension and haemostatic disorders.
Trifiletti
A
A
Department of Internal Medicine, University of Messina, Via Monsignor D'Arrigo, 23-98121 Messina, Italy. atrifiletti@tin.it
Scamardi
R
R
Cincotta
M
M
Sottilotta
G
G
Gaudio
A
A
Romano
C
C
Sottile
L
L
Lasco
A
A
D000328:Adult; D001778:Blood Coagulation Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male