title: Polymorphism screening of four genes encoding advanced glycation end-product putative receptors. Association study with nephropathy in type 1 diabetic patients.
abstract: Advanced glycation end-products (AGEs) may play an important role in the pathogenesis and progression of cardiovascular and renal complications of diabetes. Four putative AGE receptors (RAGEs), AGE-R1, AGE-R2, and AGE-R3 have been described. In this study, we scanned the sequence of the genes encoding these AGE receptors in 48 patients with type 1 diabetes and investigated the identified polymorphisms (n = 19) in 199 type 1 diabetic patients with nephropathy and 193 type 1 diabetic patients without nephropathy. Overall, none of the polymorphisms was strongly associated with nephropathy. The minor allele of a polymorphism located in the promoter region of the RAGE gene (C-1152A) conferred a weak protective effect (P < 0.05) and was associated with a longer duration of nephropathy-free diabetes (P = 0.08).
authors.affiliation: Institut National de la Santé et de la Recherche Médicale INSERM U525/SC7, Paris, France.
authors.forename: O
authors.initials: O
authors.lastname: Poirier
authors.forename: V
authors.initials: V
authors.lastname: Nicaud
authors.forename: N
authors.initials: N
authors.lastname: Vionnet
authors.forename: S
authors.initials: S
authors.lastname: Raoux
authors.forename: L
authors.initials: L
authors.lastname: Tarnow
authors.forename: H
authors.initials: H
authors.lastname: Vlassara
authors.forename: H H
authors.initials: HH
authors.lastname: Parving
authors.forename: F
authors.initials: F
authors.lastname: Cambien
mesh_terms: D020121:5' Untranslated Regions / Q000235:genetics; D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D002896:Chromosomes, Human, Pair 6; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics* / Q000503:physiopathology; D003928:Diabetic Nephropathies / Q000235:genetics*; D005820:Genetic Testing; D017127:Glycation End Products, Advanced / Q000378:metabolism; D006720:Homozygote; D006801:Humans; D017354:Point Mutation; D011110:Polymorphism, Genetic; D011401:Promoter Regions, Genetic; D020033:Protein Isoforms / Q000235:genetics; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic / Q000235:genetics*
chemical_list: D020121:5' Untranslated Regions; D017127:Glycation End Products, Advanced; D020033:Protein Isoforms; D000067759:Receptor for Advanced Glycation End Products; D011971:Receptors, Immunologic