[Plasmatic concentrations of fibronectin as marker of clinical course among septic patients].
BACKGROUND
It is difficult to follow up the patients with sepsis because of the underlying pathology or the presence of complications. The attending physician needs to know as soon as possible the response to the antibiotic therapy. Is therefore necessary to find real time biological markers that will help to understand the clinical situation of the infected patient. It has been demonstrated that fibronectin (Fn) is an early marker of sepsis, so it seemed plausible its use in the clinical monitoring of the septic patient.


METHODS
We have used plasmatic concentrations of Fn in the follow up of sepic patients admitted to the Hospital de Segovia from February to August, 1995. There were two control groups: one of healthy volunteers and another of varied pathology.


RESULTS
We have applied the multiple comparison rule of Bonferroni to demonstrate that plasma Fn is a negative acute phase reactant, with almost undetectable levels while the patient is in critical condition. An effective treatment prompts plasma Fn to rise significantly within two days.


CONCLUSIONS
Plasma Fn concentration by itself or in an score system could help in the follow up of the septic patients.
Ruiz
G
G
Departamento de Microbiologia, Facultad de Medicine, Universidad Complutense de Marrid, Spain.
Veiga
J
J
Luisa Gómez-Lus
M
M
García-Carbajosa
S
S
Prieto
J
J
D000210:Acute-Phase Reaction / Q000097:blood; D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008297:Male; D018805:Sepsis / Q000097:blood*
D015415:Biomarkers; D005353:Fibronectins