Fine-needle aspiration biopsy allows early detection of acute rejection in children after renal transplantation.
analysis detected rejections often before clinical signs. Half of the patients had increased serum creatinine concentration and 38% had fever at the time of rejection diagnosis. Both signs were present in only 19% of the episodes. A decrease in urine output (>20%) was seen in a third of the episodes. The rejections responded well to oral methylprednisolone (3 mg/kg/day), and lymphoglobulins were needed in only 12% of the episodes. More than 90% of the rejections were completely reversible and no transplant was lost because of acute rejection.


CONCLUSIONS
The results indicate that FNAB is a safe and sensitive method for the diagnosis and follow-up of acute cellular rejection in pediatric recipients of different ages.
Their
M
M
Hospital for Children and Adolescents, University of Helsinki, Pediatric Nephrology and Transplantation, Finland.
von Willebrand
E
E
Taskinen
E
E
Rönnholm
K
K
Holmberg
C
C
Jalanko
H
H
D000293:Adolescent; D000367:Age Factors; D001707:Biopsy, Needle / Q000379:methods / Q000592:standards; D001831:Body Temperature; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005240:Feasibility Studies; D005260:Female; D006084:Graft Rejection / Q000175:diagnosis; D006801:Humans; D007223:Infant; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology*; D008297:Male; D012189:Retrospective Studies; D016896:Treatment Outcome; D014554:Urination / Q000502:physiology
D003404:Creatinine