[Effects of reconstructive operations on the development of systemic autosensitization in patients with anophthalmos].
The role of systemic autoimmune reactions to organ-specific antigens (DNA and collagen) was studied in patients with anophthalmia before and after interventions on the stump and conjunctival cavity making use of autotransplants and synthetic implants. A total of 220 analyses of the serum were performed in the main group and 50 in the control. Autosensitization was detected in 10 (18.2%) patients. The data were processed using Statistica software. A series of previous reconstructive operations is a factor promoting the development of systemic autosensitization to collagen. A trend to an increase in the levels of antibodies to DNA and collagen was observed in the presence of cicatricial changes in adjacent tissues, foreign bodies, cartilaginous implants, and fistulas causing a latent fibrous reaction. The type of intervention (use of implants or autotransplants) does not affect the level of antibodies to DNA and collagen.
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D000293:Adolescent; D000328:Adult; D000853:Anophthalmos / Q000601:surgery*; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D003094:Collagen / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors
D001323:Autoantibodies; D003094:Collagen; D004247:DNA