CD5+ true SLL/CLL with plasmacytic differentiation and an unusual 1p36 translocation: case report and review of the literature.
Lymphoplasmacytic lymphoma (LPL) and small lymphocytic lymphoma/chronic lymphocytic leukemia (SLL/CLL)are distinct clinicopathologic entities. Although some cases of SLL/CLL may show plasmacytic differentiation and be associated with monoclonal immunoglobulin in serum, such cases appear to be very rare, and if plasma cell differentiation were marked, differentiation of SLL/CLL from LPL could be difficult. We report a rare case of true CD5-positive small lymphocytic lymphoma/chronic lymphocytic leukemia with unequivocal plasmacytic differentiation. This case also showed an abnormality of chromosome 1p36 not previously described in small lymphocytic lymphoma/chronic lymphocytic leukemia.
Evans
H L
HL
Department of Pathology, Division of Hematopathology, St Louis University School of Medicine, St Louis, MO 63104, USA. evanshl@slu.edu
Polski
J M
JM
Deshpande
V
V
Dunphy
C H
CH
D000368:Aged; D018956:CD5 Antigens / Q000032:analysis*; D002454:Cell Differentiation; D002878:Chromosomes, Human, Pair 1; D020732:Cytogenetic Analysis; D003937:Diagnosis, Differential; D005434:Flow Cytometry; D006801:Humans; D016130:Immunophenotyping; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics / Q000473:pathology; D008297:Male; D010950:Plasma Cells / Q000473:pathology; D014178:Translocation, Genetic
D018956:CD5 Antigens