title: A phosphodiesterase from ascites carcinoma Krebs II cells specifically cleaves the bond between VPg and RNA of encephalomyocarditis virus.
abstract: The substrate specificity of the "unlinking" enzyme from ascite carcinoma Krebs II cells has been investigated. The enzyme specifically splits the interpolymeric phosphodiester bond between Kp and the 5;-terminal phosphate group of the uridylic acid residue in the Kp-pUpUpGp complex.
authors.affiliation: Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Moscow, 119899, Russia.
authors.forename: A Y
authors.initials: AY
authors.lastname: Gulevich
authors.forename: R A
authors.initials: RA
authors.lastname: Yusupova
authors.forename: Y F
authors.initials: YF
authors.lastname: Drygin
mesh_terms: D000818:Animals; D001201:Ascites / Q000201:enzymology*; D002277:Carcinoma / Q000201:enzymology*; D002855:Chromatography, Thin Layer; D004686:Encephalomyocarditis virus / Q000378:metabolism*; D006868:Hydrolysis; D051379:Mice; D010727:Phosphoric Diester Hydrolases / Q000737:chemistry*; D011485:Protein Binding; D012313:RNA / Q000378:metabolism*; D014407:Tumor Cells, Cultured; D014758:Viral Core Proteins / Q000378:metabolism*
chemical_list: D014758:Viral Core Proteins; D012313:RNA; D010727:Phosphoric Diester Hydrolases