Effects of growth hormone and its secretagogues on bone.
The growth hormone (GH)/insulin-like growth factor-1 axis is not only of importance for linear body growth during childhood, but it is also one of the major determinants of adult bone mass. Studies show that GH treatment increases bone mass in rodents as well as in adult GH-deficient humans, but the effect of GH treatment on bone mass in healthy humans has so far not been impressive. Recently, a new class of GH secretagogues (GHSs) has been developed. In humans, GHS treatment affects biochemical markers of bone turnover and increases growth velocity in selected short children with or without GH deficiency. In rodents, GHS treatment increase bone mineral content, but it has not yet been shown that GHS treatment can affect bone mass in adult humans.
Svensson
J
J
Research Centre for Endocrinology and Metabolism, Sahlgrenska University Hospital, Göteborg, Sweden. johan.svensson@medic.gu.se
Lall
S
S
Dickson
S L
SL
Bengtsson
B A
BA
Rømer
J
J
Ahnfelt-Rønne
I
I
Ohlsson
C
C
Jansson
J O
JO
D000328:Adult; D000367:Age Factors; D000818:Animals; D001846:Bone Development / Q000187:drug effects; D016723:Bone Remodeling / Q000187:drug effects*; D001862:Bone Resorption / Q000503:physiopathology; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects; D054439:Ghrelin; D013006:Growth Hormone / Q000172:deficiency / Q000494:pharmacology*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D007211:Indoles / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D009929:Organ Size; D036361:Peptide Hormones; D010455:Peptides / Q000494:pharmacology; D013141:Spiro Compounds / Q000494:pharmacology
D054439:Ghrelin; D006728:Hormones; D007211:Indoles; D009842:Oligopeptides; D036361:Peptide Hormones; D010455:Peptides; D013141:Spiro Compounds; C086184:hexarelin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; C094817:ibutamoren mesylate