The potential of radioiodinated (-)-m-iodovesamicol for diagnosing cholinergic deficit dementia.
We investigated changes in the brain distribution of (-)-[(125)I]-m-iodovesamicol [(-)-[(125)I]mIV] in cholinergic denervation rats produced by a unilateral lesion of the nucleus basalis magnocellularis (NBM). Dual-tracer ex vivo autoradiographic analysis using (-)-[(125)I]mIV and [(99m)Tc]HMPAO was conducted to the effect of regional cerebral perfusion on the brain distribution of (-)-[(125)I]mIV in a unilateral NBM-lesioned rat. (-)-[(125)I]mIV binding in the ipsilateral cortex to the lesion significantly reduced by 10.4 %, compared with that in the contralateral cortex, while (-)-[(125)I]mIV binding in the ipsilateral caudate putamen, hippocampus and thalamus did not change. The rate of reduction in the (-)-[(125)I]mIV binding (10.4 %) was significantly higher than that of [(99m)Tc]HMPAO accumulation (4.0%) in the ipsilateral cortex to the lesion (P < 0.01). These results suggested that radioiodinated (-)-mIV may be useful in the study of dementia characterized by degeneration of the cholinergic neurotransmitter system, such as Alzheimer's disease.
Shiba
K
K
Radioiosotope Center, Kanazawa University, Kanazawa, Japan. shiba@med.kanazawa-u.ac.jp
Mori
H
H
Ikeda
E
E
Sumiya
H
H
Tonami
N
N
D000109:Acetylcholine / Q000172:deficiency; D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D003704:Dementia / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D010880:Piperidines / Q000493:pharmacokinetics; D011877:Radionuclide Imaging; D051381:Rats; D017207:Rats, Sprague-Dawley; D019690:Technetium Tc 99m Exametazime; D014018:Tissue Distribution
D010880:Piperidines; C103554:3-iodovesamicol; D019690:Technetium Tc 99m Exametazime; D000109:Acetylcholine