Hyperhomocysteinemia in myelodysplastic syndromes: specific association with autoimmunity and cardiovascular disease.
Hyperhomocysteinemia (HH) has been associated with cardiovascular and autoimmune diseases and oxidative cell damage. Myelodysplastic syndromes (MDS) are associated with autoimmunity (AI) and increased oxidative stress. We tested the association of HH and oxidative stress in 33 MDS patients, by measuring plasma homocysteine and malondialdehyde (MDA). HH was found in 42% of cases, (4/5) cases with associated cardiovascular events (CVE)(80%), and 9/15 cases with associated AI (60%). Thus in MDS, HH was significantly associated with AI/CVE (chi(2) : p=0.0011), and this association seems to be specific, as demonstrated by the comparison of MDS presenting AI/CVE with the ischemic cardiopathy/rheumatoid arthritis control group (13/20, 65% vs 19/69, 27%; chi(2) : p=0.0021). The levels of MDA indicated increased oxidative stress. Our data may suggest that in a subset of MDS, HH may simultaneously contribute to bone marrow myelodysplasia, CVE and AI pathogenesis, possibly through oxidative cell damage.
Cortelezzi
A
A
Dipartimento di Ematologia, Ospedale Maggiore IRCCS and Dipartimento di Scienze Mediche; Università degli Studi di Milano, Italy. cortelez@polic.cilea.it
Fracchiolla
N S
NS
Bamonti-Catena
F
F
Motta
M
M
Cighetti
G
G
Carrabba
M
M
Cavalca
V
V
Maiolo
A T
AT
Lambertenghi Deliliers
G
G
D000704:Analysis of Variance; D015551:Autoimmunity / Q000502:physiology; D002318:Cardiovascular Diseases / Q000097:blood / Q000209:etiology; D016022:Case-Control Studies; D005215:Fasting; D006710:Homocysteine / Q000097:blood; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications*; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D009190:Myelodysplastic Syndromes / Q000097:blood / Q000150:complications* / Q000276:immunology; D018384:Oxidative Stress / Q000502:physiology
D006710:Homocysteine; D008315:Malondialdehyde