title: [Acute lymphoblastic leukemia with Philadelphia chromosome: eight case reports].
abstract: Philadelphia chromosome-positive (Ph+) acute lymphoblastic leukemia (ALL) is an aggressive form of acute leukemia that children ALL. Between 1991 and 1998, eight cases Ph+ ALL (7 males and one female) were diagnosed in our institution by successful cytogenetic studies. Median age was 37 years (range, 1-60 years). Leukocyte count was more than 50 x 109/l in 5 cases. According to the French-American-British (FAB) criteria, six patients were classified L1 and two L2. The Ph+ as sole anomaly was seen in 2 patients (25%), while additional chromosome changes were observed in 6 cases. Complete remission was achieved in 5 cases (62%) and relapse was observed in all cases? The 2-year survival rae was 25% confirming the worse prognosis of this leukemia when treated with standard chemotherapy.
authors.affiliation: Service d'Hématologie Clinique, CHU Farhat Hached de Sousse-Tunisie.
authors.forename: M A
authors.initials: MA
authors.lastname: Laatiri
authors.forename: S
authors.initials: S
authors.lastname: Chehata
authors.forename: A
authors.initials: A
authors.lastname: Amouri
authors.forename: H S
authors.initials: HS
authors.lastname: Sendi
authors.forename: A
authors.initials: A
authors.lastname: Saad
authors.forename: S
authors.initials: S
authors.lastname: Ennabli
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003582:Cytogenetics; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007621:Karyotyping; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics*; D011379:Prognosis; D012074:Remission Induction / Q000379:methods; D016019:Survival Analysis; D014178:Translocation, Genetic