High cardiac angiotensin-II-forming activity in infarcted and non-infarcted human myocardium.
The aims of this study were to compare human cardiac angiotensin-II-forming activity (AIIFA) between the intact area of control autopsy hearts without cardiac disease (n = 10) and the infarcted or non-infarcted area of autopsy hearts with myocardial infarction (MI, n = 7) and to determine responsible angiotensin-II-forming enzymes. Cardiac total and chymase-dependent AIIFAs were significantly higher in the infarcted and non-infarcted myocardium than those in non-MI heart, while angiotensin-converting enzyme-dependent AIIFA increased only in the infarcted myocardium. The density of chymase antibody-positive mast cells in the non-infarcted area of MI heart correlated positively with total or chymase-dependent AIIFA. Augmented AIIFA was also detected in the left atrium of post-MI hearts. Our results indicated that cardiac angiotensin II formation could be activated in the infarcted as well as in non-infarcted myocardium of the post-MI human heart.
Ihara
M
M
Department of Internal Medicine, Fukuoka University School of Medicine, Fukuoka, Japan.
Urata
H
H
Shirai
K
K
Ideishi
M
M
Hoshino
F
F
Suzumiya
J
J
Kikuchi
M
M
Arakawa
K
K
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000804:Angiotensin II / Q000032:analysis; D001344:Autopsy; D053818:Chymases; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000473:pathology*; D007703:Peptidyl-Dipeptidase A / Q000032:analysis*; D012083:Renin / Q000378:metabolism*; D012697:Serine Endopeptidases / Q000378:metabolism
D000804:Angiotensin II; D007703:Peptidyl-Dipeptidase A; D012697:Serine Endopeptidases; D053818:Chymases; D012083:Renin