[Relationship between structural brain abnormalities and psychopathologic profile in patients with schizophrenia].
Aim of this study was to determine the presence of structural brain abnormalities, dynamics of psychopathology three and seven years after the first hospitalisation and correlation between them. We examined 59 first admitted schizophrenic patients. We used computed tomography to examine structural brain abnormalities and BPRS-LA to measure the psychopathology level. CT and BPRS measures were both completed 3 years after the first admission. 7 years after the first admission the psychopathology level was measured with BPRS. We observed spaces in the brain and cortical sulci widened in 55 subjects (93%). The most commonly met structural brain pathology was a widening of the IIIrd ventricle and frontal cortex pathology. Assessment of the dynamics of psychopathology shows stability of the negative syndrome and increase of the positive syndrome and general psychopathology between the third and the seventh year of the illness. Three years after first admission, structural brain pathology in the left temporal cortex and frontal cortex correlate with the overall level of psychopathology measured with BPRS-LA, but this correlation vanishes in seventh-year catch-up. Seven years after first admission subcortical cerebral pathology, especially in the subcortical frontal area correlate significantly (p < 0.01) with a lower level of positive symptoms.
Walczewski
K
K
Cechnicki
A
A
Matkowski
J
J
Kleinrok
K
K
Herman
I
I
Podsiadło-Kleinrok
B
B
D000328:Adult; D001927:Brain Diseases / Q000150:complications* / Q000000981:diagnostic imaging*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging; D014695:Cerebral Ventriculography; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D012559:Schizophrenia / Q000209:etiology*; D013702:Temporal Lobe / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed