Antipyretic effect of neuropeptide galanin in endotoxin-induced fever.
Neuropeptide galanin produces a antipyretic effect in experimental pyrogenic reaction induced by intraperitoneal injection of lipopolysaccharide. Central intracerebroventricular injection of 100 ng galanin significantly attenuated, but did not completely abolish fever. Central galanin injection potentiated endotoxin-induced activation of the noradrenergic system and blocked activation of the serotoninergic system of the anterior hypothalamus.
Lyudyno
V I
VI
Institute of Experimental Medicine, Russian Academy of Medical Science, St.-Petersburg. klim@iemcns.spb.su
Krasnova
I N
IN
Smirnova
M P
MP
Klimenko
V M
VM
D000818:Animals; D001831:Body Temperature / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy*; D019004:Galanin / Q000494:pharmacology / Q000627:therapeutic use*; D007032:Hypothalamus, Anterior / Q000378:metabolism; D008070:Lipopolysaccharides; D008297:Male; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D008070:Lipopolysaccharides; D018377:Neurotransmitter Agents; D019004:Galanin