The role of Pax6 in brain patterning.
Pax6 g ene encodes a transcription factor that plays a pivotal role in various aspects of brain development. Here I review the molecular and cellular mechanisms of how the early brain is patterned, and introduce recent studies on the role of Pax6 in brain patterning, neuronal specification, neuronal migration and axonal extension.
Osumi
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Department of Developmental Neurobiology, Tohoku University Graduate School of Medicine, Sendai, Japan.
D000818:Animals; D001921:Brain / Q000166:cytology / Q000254:growth & development*; D015820:Cadherins / Q000502:physiology; D005136:Eye Proteins; D018398:Homeodomain Proteins / Q000502:physiology*; D006801:Humans; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors / Q000502:physiology*
D015820:Cadherins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D000071841:PAX6 Transcription Factor; C000605730:PAX6 protein, human; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors