Physiological responses to lysophosphatidic acid and related glycero-phospholipids.
1-Acyl-2-hydroxy(lyso)-sn-glycero-3-phosphate (lysophosphatidic acid, LPA) has attracted a lot of attention in recent years due to the wide range of its biological effects that span the phylogenetic tree from slime mold to human. LPA can be viewed as a pleiotropic phospholipid growth factor that utilizes the same signal transduction mechanisms as traditional polypeptide growth factors; however, LPA activates these mechanism via specific G protein-coupled receptors. The concentration of LPA in serum is in the high micromolar range, making it the most abundant mitogen/survival factor present in serum, one that is often unknowingly utilized in tissue culture. The present review gives a historical perspective and a critical analysis of the LPA literature with a special emphasis on the physiological implications of its effects.
Tigyi
G
G
Department of Physiology, University of Tennessee Health Sciences Center Memphis, 38163, USA. gtigyi@physiol.utmem.edu
D002453:Cell Cycle; D004730:Endothelium, Vascular / Q000502:physiology; D020404:Glycerophospholipids / Q000502:physiology*; D008246:Lysophospholipids / Q000502:physiology*; D016239:MEDLINE; D015539:Platelet Activation / Q000502:physiology; D012098:Reproduction / Q000502:physiology; D015398:Signal Transduction; D014945:Wound Healing / Q000502:physiology
D020404:Glycerophospholipids; D008246:Lysophospholipids