title: Hamartomas of the breast: clinical, radiologic, and pathologic manifestations.
abstract: Between 1986 and 1996, 35 patients with a diagnosis of hamartoma of the breast were seen at the Mayo Clinic. One patient had two lesions. The mean age was 50 years (range 21-86 years). Hamartomas were clinically identified as a palpable lump in 18 cases (11 were detected by the patient and 7 by a physician). The other 18 were identified mammographically. Twenty-four lesions were in the left breast and 12 were in the right breast; 39% were located in the upper outer quadrant. Mammographically most hamartomas were ovoid, and the lesions were well circumscribed. Sonographically they were all solid, but 24% showed cystic areas. Pathologically the mean greatest diameter was 3.2 cm (range 1.0-7.5 cm). All but one lesion showed circumscription. The mean percentage of fibrous tissue was 78% (range 5-95%), fat 13% (range 0-95%), and epithelium 9% (range 1.0-60%). Calcifications were seen in four lesions. Ductal hyperplasia was present in 27% and adenosis in 70% of lesions. Twelve percent of patients had coexistent fibroadenomas.
authors.affiliation: Breast Clinic, Division of General Internal Medicine, Division of Anatomic Pathology, Department of Diagnostic Radiology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Wahner-Roedler
authors.forename: T J
authors.initials: TJ
authors.lastname: Sebo
authors.forename: J J
authors.initials: JJ
authors.lastname: Gisvold
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006222:Hamartoma / Q000000981:diagnostic imaging / Q000473:pathology*; D006801:Humans; D008499:Medical Records; D008875:Middle Aged; D011859:Radiography; D012189:Retrospective Studies; D014463:Ultrasonography