title: The cerebral proteopathies: neurodegenerative disorders of protein conformation and assembly.
abstract: The abnormal assembly and deposition of specific proteins in the brain is the probable cause of most neurodegenerative disease afflicting the elderly. These "cerebral proteopathies" include Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), prion diseases, and a variety of other disorders. Evidence is accumulating that the anomalous aggregation of the proteins, and not a loss of protein function, is central to the pathogenesis of these diseases. Thus, therapeutic strategies that reduce the production, accumulation, or polymerization of pathogenic proteins might be applicable to a wide range of some of the most devastating diseases of old age.
authors.affiliation: Neuroscience Therapeutics, Pfizer Ann Arbor Laboratories, MI 48105, USA.
authors.forename: L C
authors.initials: LC
authors.lastname: Walker
authors.forename: H
authors.initials: H
authors.lastname: LeVine
mesh_terms: D016229:Amyloid beta-Peptides / Q000737:chemistry / Q000378:metabolism*; D000686:Amyloidosis / Q000235:genetics / Q000473:pathology / Q000628:therapy; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology*; D006801:Humans; D017096:Prion Diseases / Q000235:genetics / Q000378:metabolism* / Q000473:pathology* / Q000628:therapy; D011487:Protein Conformation
chemical_list: D016229:Amyloid beta-Peptides