Human herpesvirus 8 DNA sequences are present in bone marrow from HIV-negative patients with lymphoproliferative disorders and from healthy donors.
Bone marrow (BM) from patients affected by multiple myeloma (MM), exhibiting monoclonal gammopathy of undetermined significance (MGUS) or with non-Hodgkin lymphoma (NHL) as well as from healthy donors were investigated for the presence of human herpesvirus-8 (HHV-8) DNA sequences. ORF 26 sequences were detected in 36--56% of the patients and in 29% of the controls. In a few cases, two other HHV-8 DNA sequences were also detected. These observations indicate that the presence of the HHV-8 genome in BM is relatively common in different groups of patients as well as in healthy individuals and do not support an alleged role for HHV-8 in MM.
Azzi
A
A
Department of Public Health and Epidemiology, Microbiology and Virology Unit, University of Florence, Italy. azzi@dsp.igiene.unifi.it
Fanci
R
R
De Santis
R
R
Ciappi
S
S
Paci
C
C
D001853:Bone Marrow / Q000821:virology*; D001854:Bone Marrow Cells / Q000821:virology; D016022:Case-Control Studies; D002478:Cells, Cultured; D004279:DNA, Viral / Q000032:analysis*; D019288:Herpesvirus 8, Human / Q000235:genetics*; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000821:virology; D008232:Lymphoproliferative Disorders / Q000821:virology*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000821:virology; D010265:Paraproteinemias / Q000821:virology
D004279:DNA, Viral