Correlation between acute phase-related expression of C/EBPbeta and transcriptional regulation of the haptoglobin gene during rat liver development.
The hepatic 35 kD nucleoprotein participates in transcriptional regulation of the haptoglobin gene during the development of rat liver. The same molecular mass and trans-acting role of the above protein as the active isoform of C/EBPbeta transcription factor, made homology between them possible. We could detect C/EBPbeta in control hepatic nuclear extracts not earlier than in the second week after the birth. However, the acute-phase reaction induced the expression of 35 kD-C/EBPbeta at day 7 of postnatal development suggesting that the above trans-active nucleoprotein displays the structural and functional characteristics of C/EBPbeta isoform from that day on.
Mihailović
M
M
Institute for Biological Research, Belgrade, Yugoslavia.
Petrović
M
M
Bogojević
D
D
D000818:Animals; D000831:Animals, Newborn; D015139:Blotting, Southern; D015153:Blotting, Western; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000096:biosynthesis* / Q000737:chemistry; D018507:Gene Expression Regulation, Developmental; D006242:Haptoglobins / Q000096:biosynthesis* / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism; D008099:Liver / Q000196:embryology* / Q000378:metabolism*; D009698:Nucleoproteins / Q000378:metabolism; D020033:Protein Isoforms; D051381:Rats; D013997:Time Factors; D014158:Transcription, Genetic
D022782:CCAAT-Enhancer-Binding Protein-beta; D006242:Haptoglobins; D009698:Nucleoproteins; D020033:Protein Isoforms