[The preparation of poly (DL-lactide) hollow fiber and the release of drug in vitro].
The biodegradable hollow fibers of DL-PLA were prepared by a dry-wet phase inversion spinning process. By using four different spinning systems, DL-PLA hollow fibers with varying asymmetric membrane structure were obtained. The structure of hollow fiber wall was examined by SEM. In vitro release of norethisterone from the DL-PLA hollow fibers was also investigated. The hollow fibers were filled with a 50 wt% NET in castor oil. The DL-PLA hollow fibers NET release was found to be dependent on the membrane structure of the hollow fiber wall. Possible release mechanisms were discussed.
Zhu
J
J
Zhejiang Accademy of Medical Sciences, Hangzhou 310013.
Shen
Z
Z
Ma
Z
Z
Wu
L
L
Shi
D
D
D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D019344:Lactic Acid; D009640:Norethindrone; D011091:Polyesters; D011108:Polymers
D003692:Delayed-Action Preparations; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D009640:Norethindrone