Centrosome abnormalities, genomic instability and carcinogenic progression.
Centrosome abnormalities are a frequent finding in various malignant tumors. Since centrosomes form the poles of the mitotic spindle, these abnormalities have been implicated in chromosome missegregation and the generation of aneuploid cells which is commonly found in many human neoplasms. It is a matter of debate, however, whether centrosome alterations can drive cells into aneuploidy or simply reflect loss of genomic integrity by other mechanisms. Since these two models have fundamentally different implications for the diagnostic and prognostic value of centrosome abnormalities, we will discuss the relevance of abnormal centrosomes in the context of different oncogenic events as exemplified by high-risk human papillomavirus-associated carcinogenesis.
Duensing
S
S
Department of Pathology and Center for Cancer Biology, Harvard Medical School, Armenise Research Building, D2 544A, 200 Longwood Avenue, Boston, MA 02115-5701, USA.
Münger
K
K
D000782:Aneuploidy; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure; D018385:Centrosome / Q000473:pathology* / Q000648:ultrastructure; D020090:Chromosome Segregation; D005260:Female; D015894:Genome, Human; D006801:Humans; D009856:Oncogene Proteins, Viral / Q000235:genetics / Q000378:metabolism; D027383:Papillomaviridae; D050725:Papillomavirus E7 Proteins; D011379:Prognosis; D012097:Repressor Proteins; D014407:Tumor Cells, Cultured; D014412:Tumor Virus Infections / Q000235:genetics* / Q000473:pathology; D002583:Uterine Cervical Neoplasms / Q000235:genetics* / Q000473:pathology / Q000648:ultrastructure
C068651:E6 protein, Human papillomavirus type 16; D009856:Oncogene Proteins, Viral; D050725:Papillomavirus E7 Proteins; D012097:Repressor Proteins; C059731:oncogene protein E7, Human papillomavirus type 16