title: Comparison of clinical, serological and histological findings between non-ulcer dyspepsia patients with and without Helicobacter pylori infection.
abstract: OBJECTIVE
  The role of Helicobacter pylori (H. pylori) infection in non-ulcer dyspepsia (NUD) remains controversial. This study investigates the clinical, serological and histological differences between patients with H. pylori-positive and -negative NUD.
  
  
  METHODS
  One hundred and eighty consecutive patients with NUD were enrolled from January to December 1998. The severity of symptoms was evaluated by the Tucci's scoring system. The histological changes of gastric mucosa were assessed according to the Updated Sydney System, and a fasting blood sample was obtained to test the serum gastrin and pepsinogen I levels.
  
  
  RESULTS
  The H. pylori-positive NUD patients were notably older than H. pylori-negative NUD patients (48.2 +/- 15.9 vs 39.8 +/- 15.7 years, P= 0.001). There were no differences in other clinical factors between the two NUD groups. The serum pepsinogen I levels were considerably higher in H. pylori-positive NUD patients than in H. pylori-negative NUD patients (78.9 +/- 42.2 vs 61.5 +/- 43.3 ng/mL, P<0.01). However, no significant differences in serum gastrin levels were discovered between the two groups. The antrum histological scores for chronic inflammation, acute inflammation, gland atrophy and lymphoid follicles were higher in H. pylori-positive NUD patients than in H. pylori-negative NUD patients (2.09 vs 1.01, P<0.001; 1.22 vs 0.36, P<0.001; 0.76 vs 0.36, P<0.01; 0.33 vs 0.13, P<0.01, respectively).
  
  
  CONCLUSIONS
  The present study discovered marked differences in age, serum pepsinogen I levels, histological grades of acute inflammation, chronic inflammation, gland atrophy and lymphoid tissue formation between H. pylori-positive and H. pylori-negative NUD patients. Further investigation of the clinical prognosis of the two groups of patients is necessary.
authors.affiliation: Department of Internal Medicine, Kaohsiung Veterans General Hospital, Taiwan, Republic of China.
authors.forename: C C
authors.initials: CC
authors.lastname: Lo
authors.forename: P I
authors.initials: PI
authors.lastname: Hsu
authors.forename: G H
authors.initials: GH
authors.lastname: Lo
authors.forename: K H
authors.initials: KH
authors.lastname: Lai
authors.forename: J S
authors.initials: JS
authors.lastname: Cheng
authors.forename: H H
authors.initials: HH
authors.lastname: Tseng
authors.forename: C K
authors.initials: CK
authors.lastname: Lin
authors.forename: H H
authors.initials: HH
authors.lastname: Chan
authors.forename: Y Y
authors.initials: YY
authors.lastname: Wang
authors.forename: M K
authors.initials: MK
authors.lastname: Ku
authors.forename: C P
authors.initials: CP
authors.lastname: Lin
authors.forename: N J
authors.initials: NJ
authors.lastname: Peng
authors.forename: E J
authors.initials: EJ
authors.lastname: Chien
mesh_terms: D000328:Adult; D004415:Dyspepsia / Q000097:blood / Q000382:microbiology* / Q000473:pathology*; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000097:blood; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A / Q000097:blood
chemical_list: D005755:Gastrins; D020116:Pepsinogen A