title: Initial experience with fenoldopam in children.
abstract: Fenoldopam is a direct-acting vasodilator that acts at the postsynaptic dopamine 1 receptors in renal, coronary, cerebral, and splanchnic vasculature resulting in arterial dilation and a lowering of the mean arterial pressure (MAP). Preliminary evidence suggests its efficacy in the treatment of hypertensive urgencies and emergencies in adults. We present four children in whom fenoldopam was used to control MAP in various clinical scenarios, including hypertensive emergencies and urgencies, intraoperative reduction of MAP for controlled hypotension, and control of MAP during extracorporeal membrane oxygenation. The possible applications of fenoldopam and suggested dosing regimens in children are reviewed.
authors.affiliation: Department of Child Health, Division of Pediatric Critical Care/Pediatric Anesthesiology, University of Missouri, Columbia, MI 65212, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Strauser
authors.forename: R D
authors.initials: RD
authors.lastname: Pruitt
authors.forename: J D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000367:Age Factors; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001835:Body Weight; D001932:Brain Neoplasms / Q000601:surgery; D002648:Child; D018491:Dopamine Agonists / Q000494:pharmacology / Q000627:therapeutic use*; D004630:Emergencies; D005260:Female; D018818:Fenoldopam / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D007223:Infant; D007262:Infusions, Intravenous; D007431:Intraoperative Complications / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008527:Medulloblastoma / Q000601:surgery; D015701:Near Drowning / Q000150:complications; D011183:Postoperative Complications / Q000188:drug therapy / Q000209:etiology; D012600:Scoliosis / Q000601:surgery; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000959:Antihypertensive Agents; D018491:Dopamine Agonists; D014665:Vasodilator Agents; D018818:Fenoldopam