[Heterogenous reaction of cancer cells to cisplatin].
During a study involving treatment of MCF-7 culture of mammary tumor cells with cisplatin 5.10, 15.20 and 25 microM, an inverse correlation was found between the first two doses and the number of dead cells; later on, this fraction diminished gradually to basal level. Conversely, the fraction of necrotized cells increased in proportion to dosage, overall toxicity of cisplatin (the sum total of dead cells) remaining unchanged when in excess of 10 microM.
Sivashinskiĭ
M S
MS
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Salganik
R I
RI
D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D002945:Cisplatin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D009336:Necrosis; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002945:Cisplatin