title: Breast conservation therapy with tumor bed irradiation alone in a selected group of patients with stage I breast cancer.
abstract: Radiotherapy after breast-conserving surgery increases local control. We tested the feasibility of limited surgery with tumor bed irradiation only with 192Ir in a selected group of patients with stage I breast cancer. Twenty-five breasts in 24 women more than 60 years old with low- or intermediate-grade stage I tumors were treated with placement of interstitial catheters at the time of lumpectomy and axillary node dissection. This procedure was followed by after-loading with low-dose 192Ir to deliver 20-25 Gy to the tumor bed over 24-48 hours. There were neither local recurrences in the breast nor distant recurrences at a median follow-up of 47 months (range 25-90 months). Cosmetic appearance ranged from very good to excellent. There were no long-term complications. It is feasible to treat a select group of patients with tumor bed irradiation, using relatively low doses of interstitial irradiation, with excellent local control and no significant morbidity.
authors.affiliation: Department of Radiation Oncology, University of Kansas Medical Center, Kansas City, Kansas 66160-7321, USA. lkrishna@kumc.edu
authors.forename: L
authors.initials: L
authors.lastname: Krishnan
authors.forename: W R
authors.initials: WR
authors.lastname: Jewell
authors.forename: O W
authors.initials: OW
authors.lastname: Tawfik
authors.forename: E C
authors.initials: EC
authors.lastname: Krishnan
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001918:Brachytherapy; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use; D015412:Mastectomy, Segmental; D008875:Middle Aged; D009367:Neoplasm Staging; D010865:Pilot Projects; D016896:Treatment Outcome
chemical_list: D007496:Iridium Radioisotopes