title: Renal cell carcinoma and malignant phase hypertension.
abstract: Many cross-sectional and follow-up studies of large numbers of patients with hypertension have demonstrated an increased prevalence and mortality from renal cancer. We report the details of three patients with renal cell carcinoma from a series of 254 consecutive patients with malignant phase hypertension, an excess over the expected number reported from several large published series with non-malignant hypertension. In view of this excess we investigated the prevalence of hypertension in a series of 192 consecutive patients who presented with a diagnosis of renal cell carcinoma, in comparison with a local unselected population screening survey. Hypertension was found in 43% of the renal carcinoma patients and 20% of the local population, also a clear excess. The mechanism of the association between renal cancer and malignant and non-malignant hypertension is unclear.
authors.affiliation: Department of Medicine, City Hospital, Birmingham, UK.
authors.forename: P S
authors.initials: PS
authors.lastname: Wong
authors.forename: G Y
authors.initials: GY
authors.lastname: Lip
authors.forename: J C
authors.initials: JC
authors.lastname: Gearty
authors.forename: D G
authors.initials: DG
authors.lastname: Arkell
authors.forename: A J
authors.initials: AJ
authors.lastname: Howie
authors.forename: M A
authors.initials: MA
authors.lastname: Ferreira
authors.forename: D G
authors.initials: DG
authors.lastname: Beevers
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000150:complications* / Q000453:epidemiology; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D006974:Hypertension, Malignant / Q000150:complications* / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012189:Retrospective Studies