title: [Leg ulcers and cancer. 6 case reports].
abstract: OBJECTIVE
  It is estimated that 1 leg ulcer out of 300 is a carcinoma. In the literature ulceration of skin cancer is distinguished from chronic leg ulcers although this later category remains a subject of debate. We examined the clinical features of suspected malignant leg ulcers and discuss the notion of secondary malignant transformation of leg ulcers.
  
  
  METHODS
  This study included patients attending the Vascular Clinic at the Saint-Joseph Hospital in Paris between 1991 and 1999 who were referred for leg ulcers and whose final diagnosis was cancerous ulceration.
  
  
  RESULTS
  There were six patients, mean age 77 years who had squamous cell carcinomas (4 cases) and basocellular carcinomas (2 cases). We observed two distinct situations: leg carcinomas that ulcerated from onset (2 cases) and malignant transformation of a cicatrix, known as Marjolin's ulcer (4 cases). There were no cases of malignant transformation of chronic leg ulcers in this series. The clinical elements suggestive of a cancerous leg ulcer were the absence of a vascular etiology, the red, budding aspect of the ulcer with hard borders, and its development on a cicatrix.
  
  
  CONCLUSIONS
  Malignant transformation of a vascular leg ulcer was not observed in our series, but has been reported in the literature although a critical analysis of reported data is only significant for squamous cell carcinoma. The frequency is probably overestimated. Our series enabled us to identify the clinical circumstances leading to an early diagnosis of carcinoma of the lower limbs. There are three essential criteria: analysis of the vascular status of the patient, the clinical characteristics of the leg ulcer, and its development on a cicatrix.
authors.affiliation: Service de Médecine Vasculaire, Hôpital St Joseph, 185, rue Raymond Losserand, 75014 Paris.
authors.forename: J J
authors.initials: JJ
authors.lastname: Voisard
authors.forename: I
authors.initials: I
authors.lastname: Lazareth
authors.forename: E
authors.initials: E
authors.lastname: Baviera
authors.forename: P
authors.initials: P
authors.lastname: Priollet
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002280:Basal Cell Carcinoma / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D002921:Cicatrix / Q000150:complications; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000150:complications* / Q000473:pathology; D008297:Male; D012189:Retrospective Studies; D012878:Skin Neoplasms / Q000150:complications* / Q000453:epidemiology / Q000473:pathology