Chlamydia pneumoniae in multiple sclerosis: humoral immune responses in serum and cerebrospinal fluid and correlation with disease activity marker.
Humoral immune responses to Chlamydia pneumoniae (C. pneumoniae) were studied in paired sera and cerebrospinal fluid (CSF) of patients with definite multiple sclerosis (MS) and other inflammatory and non-inflammatory neurological diseases. Seropositivity was not significantly different between these groups. However, C. pneumoniae-specific IgG titers were significantly higher in CSF of MS than in controls. Sixteen out of 52 seropositive MS patients (30.8%) showed intrathecal synthesis of C. pneumoniae-specific IgG but only one of 43 seropositive controls (2.3%). In MS, this was strongly associated with intrathecal synthesis of polyclonal IgG in 13/16 patients. However, these elevated C. pneumoniae antibody titers in CSF did not significantly correlate with disease duration, disease course, clinical or MRI disease activity, disability or presence of oligoclonal IgG in MS.
Krametter
D
D
Department of Neurology, Karl-Franzens-Universität, Graz, Austria.
Niederwieser
G
G
Berghold
A
A
Birnbaum
G
G
Strasser-Fuchs
S
S
Hartung
H P
HP
Archelos
J J
JJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood / Q000134:cerebrospinal fluid; D000918:Antibody Specificity; D001327:Autoimmune Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D002556:Cerebrospinal Fluid Proteins / Q000096:biosynthesis; D002690:Chlamydia Infections / Q000150:complications / Q000453:epidemiology / Q000276:immunology* / Q000382:microbiology; D016993:Chlamydophila pneumoniae / Q000276:immunology / Q000302:isolation & purification*; D002908:Chronic Disease; D005260:Female; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*; D007249:Inflammation; D008279:Magnetic Resonance Imaging; D008297:Male; D008459:Measles virus / Q000276:immunology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000209:etiology / Q000276:immunology / Q000382:microbiology*; D009109:Mumps virus / Q000276:immunology; D009422:Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology; D015995:Prevalence; D016036:Seroepidemiologic Studies
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G