Exonic variants of the GABA(B) receptor gene and panic disorder.
The enhancement of GABAergic neurotransmission has been closely linked to antipanic drug efficacy. This is the first study to investigate a putative association of exonic sequence variants of the human GABA(B) receptor 1 (GABA(B)R1) gene and susceptibility to panic disorder. Three DNA sequence variants in exons 1a1, 7 and 11 were assessed by polymerase chain reaction-based restriction fragment length polymorphism in a case-control study among patients with panic disorder with and without agoraphobia (DSM III-R criteria) and blood donors. There was no indication of an increased vulnerability to panic disorder or agoraphobia with respect to the allelic variants under study.
Sand
P G
PG
Department of Psychiatry, University of Würzburg, Germany. philipp.sand@mail.uni-wuerzburg.de
Godau
C
C
Riederer
P
P
Peters
C
C
Franke
P
P
Nöthen
M M
MM
Stöber
G
G
Fritze
J
J
Maier
W
W
Propping
P
P
Lesch
K P
KP
Riess
O
O
Sander
T
T
Beckmann
H
H
Deckert
J
J
D000379:Agoraphobia / Q000150:complications / Q000235:genetics*; D000483:Alleles; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D004247:DNA / Q000097:blood / Q000235:genetics; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D005858:Germany; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018080:Receptors, GABA-B / Q000235:genetics*; D017422:Sequence Analysis, DNA; D044465:White People / Q000235:genetics
D018080:Receptors, GABA-B; D004247:DNA