title: Long-term potentiation induced by nicotine in CA1 region of hippocampal slice is Ca(2+)-dependent.
abstract: OBJECTIVE
  To observe the effects of Ca2+ on hippocampal long-term potentiation (LTP) induced by nicotine in CA1 region of rat hippocampal slice.
  
  
  METHODS
  Extracellularly recorded population spikes (PS) of the pyramidal cell layer in the hippocampal CA1 region in vitro.
  
  
  RESULTS
  Nicotine 1 mumol.L-1 induced LTP in the hippocampal CA1 region. It did not induce LTP in CA1 region when CA2+ was removed from artificial cerebrospinal fluid (ACSF). Nifedipine 1 and 10 mumol.L-1 partly inhibited LTP induced by nicotine, and thapsigargin 1 and 10 mumol.L-1 completely inhibited LTP induced by nicotine.
  
  
  CONCLUSIONS
  LTP induced by nicotine in hippocampal CA1 region is Ca(2+)-dependent. Both Ca2+ influx and Ca2+ release participate in the induction of LTP.
authors.affiliation: Department of Pharmacology, Sun Yat-sen University of Medical Sciences, Guangzhou, 510089, China.
authors.forename: J
authors.initials: J
authors.lastname: He
authors.forename: C Y
authors.initials: CY
authors.lastname: Deng
authors.forename: R Z
authors.initials: RZ
authors.lastname: Chen
authors.forename: X N
authors.initials: XN
authors.lastname: Zhu
authors.forename: J P
authors.initials: JP
authors.lastname: Yu
mesh_terms: D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D009538:Nicotine / Q000037:antagonists & inhibitors; D009543:Nifedipine / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D019284:Thapsigargin / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D019284:Thapsigargin; D009538:Nicotine; D009543:Nifedipine