Determination of bronopol in cosmetic products by HPLC with electrochemical detection.
A procedure is described for the assay of bronopol in cosmetics by HPLC coupled with constant-potential amperometric detection. Samples were analysed on an Alltima C18 column with methanol-phosphate buffer as the eluent and detected at a porous graphite electrode set at a reduction potential of -0.9 V. The recovery of bronopol from different cosmetic matrices was between 96.4 and 98.8% and the precision of the method was better than 4.5% relative standard deviation.
Scalia
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S
Dipartimento di Scienze Farmaceutiche, Università degli Studi di Ferrara, Italy. sls@unife.it
Simeoni
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S
Bousquet
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E
D000891:Anti-Infective Agents, Local / Q000032:analysis*; D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D003358:Cosmetics / Q000032:analysis*; D004563:Electrochemistry; D011409:Propylene Glycols / Q000032:analysis*; D013056:Spectrophotometry, Ultraviolet
D000891:Anti-Infective Agents, Local; D003358:Cosmetics; D011409:Propylene Glycols; C006827:bronopol