title: Effects of the green algae Chlorella vulgaris on the response of the host hematopoietic system to intraperitoneal ehrlich ascites tumor transplantation in mice.
abstract: Chlorella vulgaris extract (CVE) was examined for its effects on the Ehrlich ascites tumor-induced suppression in the numbers of bone marrow and spleen granulocyte-macrophage progenitor cells (CFU-GM) in mice. No effects on bone marrow and spleen CFU-GM, as compared to controls, were observed in normal mice given 50, 100 and 200 mg/kg CVE orally for 5 days. In tumor-bearing mice, myelosuppression concomitant with increased number of spleen CFU-GM were observed. The number of CFU-GM in the bone marrow was restored to control levels after the administration of CVE (50, 100 and 200 mg/kg) to tumor-bearing mice, and a slight reduction in spleen colony formation was observed in these animals. In addition, CVE significantly prolonged the survival of mice inoculated with the Ehrlich ascites tumor. These results suggest a protective antitumor effect of CVE which might be attributable, at least in part, to the stimulation of the production and, possibly, maturation of granulocytes and macrophages.
authors.affiliation: Department of Pharmacology and Hemocentre, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), SP, Brazil.
authors.forename: G Z
authors.initials: GZ
authors.lastname: Justo
authors.forename: M R
authors.initials: MR
authors.lastname: Silva
authors.forename: M L
authors.initials: ML
authors.lastname: Queiroz
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects*; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology*; D002478:Cells, Cultured; D002708:Chlorella; D003114:Colony-Forming Units Assay; D005856:Germ-Free Life; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000187:drug effects*; D006411:Hematopoiesis, Extramedullary / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D019891:Leukopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D011994:Recombinant Proteins; D013154:Spleen / Q000166:cytology; D015996:Survival Rate
chemical_list: D010936:Plant Extracts; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor