title: Aggressive incidents in first-episode psychosis.
abstract: BACKGROUND
  Recent research has reported increased risk of aggressive incidents by individuals with psychotic illness.
  
  
  OBJECTIVE
  To examine acts of aggression in first-episode psychosis.
  
  
  METHODS
  Subjects with a first-episode psychosis were ascertained from a defined catchment area (Nottingham, UK) and reassessed at 3 years (n=166) using clinical interview, informants, health care and forensic records.
  
  
  RESULTS
  Of the subjects, 9.6% demonstrated at least one act of serious aggression (defined as weapon use, sexual assault or victim injury) during at least one psychotic episode and 23.5% demonstrated lesser acts of aggression (defined as all other acts of aggression). For all aggressive subjects (33.1%), unemployment (OR=3.6, 95% C11.6-8.0), comorbid substance misuse (OR=3.1, C1 1.1-8.8) and symptoms of overactivity at service contact (OR=6.9,C1 2.7-17.8) had independent effects on risk of aggression.
  
  
  CONCLUSIONS
  We confirmed some previously reported demographic and clinical associations with aggression in first-episode psychosis but no relationship with specific psychotic symptoms or diagnostic groups was observed.
authors.affiliation: East Midlands Centre for Forensic Mental Health, Leicester, UK. John.Milton@arnoldl.cnhc-tr.trent.nhs.uk
authors.forename: J
authors.initials: J
authors.lastname: Milton
authors.forename: S
authors.initials: S
authors.lastname: Amin
authors.forename: S P
authors.initials: SP
authors.lastname: Singh
authors.forename: G
authors.initials: G
authors.lastname: Harrison
authors.forename: P
authors.initials: P
authors.lastname: Jones
authors.forename: T
authors.initials: T
authors.lastname: Croudace
authors.forename: I
authors.initials: I
authors.lastname: Medley
authors.forename: J
authors.initials: J
authors.lastname: Brewin
mesh_terms: D000293:Adolescent; D000328:Adult; D000374:Aggression; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D016017:Odds Ratio; D010554:Personality Disorders / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000523:psychology*; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000523:psychology