title: Correlation between acute phase-related expression of C/EBPbeta and transcriptional regulation of the haptoglobin gene during rat liver development.
abstract: The hepatic 35 kD nucleoprotein participates in transcriptional regulation of the haptoglobin gene during the development of rat liver. The same molecular mass and trans-acting role of the above protein as the active isoform of C/EBPbeta transcription factor, made homology between them possible. We could detect C/EBPbeta in control hepatic nuclear extracts not earlier than in the second week after the birth. However, the acute-phase reaction induced the expression of 35 kD-C/EBPbeta at day 7 of postnatal development suggesting that the above trans-active nucleoprotein displays the structural and functional characteristics of C/EBPbeta isoform from that day on.
authors.affiliation: Institute for Biological Research, Belgrade, Yugoslavia.
authors.forename: M
authors.initials: M
authors.lastname: Mihailović
authors.forename: M
authors.initials: M
authors.lastname: Petrović
authors.forename: D
authors.initials: D
authors.lastname: Bogojević
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D015139:Blotting, Southern; D015153:Blotting, Western; D022782:CCAAT-Enhancer-Binding Protein-beta / Q000096:biosynthesis* / Q000737:chemistry; D018507:Gene Expression Regulation, Developmental; D006242:Haptoglobins / Q000096:biosynthesis* / Q000378:metabolism*; D022781:Hepatocytes / Q000378:metabolism; D008099:Liver / Q000196:embryology* / Q000378:metabolism*; D009698:Nucleoproteins / Q000378:metabolism; D020033:Protein Isoforms; D051381:Rats; D013997:Time Factors; D014158:Transcription, Genetic
chemical_list: D022782:CCAAT-Enhancer-Binding Protein-beta; D006242:Haptoglobins; D009698:Nucleoproteins; D020033:Protein Isoforms