Role of apolipoprotein A-I in steroid-induced activation of DNA and protein synthesis in hepatocytes.
It is demonstrated that anabolic effect of steroid hormones is produced by steroid-apolipoprotein A-I complexes. These complexes accelerate not only protein, but also DNA synthesis and produce both cell hypertrophy and hyperplasia. For realization of their anabolic effect steroid hormones are modified by alpha- and beta-reductases in resident macrophages.
Panin
L E
LE
Institute of Biochemistry, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk.
Khoshchenko
O M
OM
Usynin
I F
IF
D000818:Animals; D016632:Apolipoprotein A-I / Q000378:metabolism / Q000494:pharmacology*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D008074:Lipoproteins / Q000378:metabolism; D008297:Male; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013256:Steroids / Q000494:pharmacology*
D016632:Apolipoprotein A-I; D008074:Lipoproteins; D013256:Steroids; D004247:DNA