title: A squamous cell carcinoma of the gastric cardia showing submucosal progression.
abstract: We report a case of squamous cell carcinoma (SCC) of the gastric cardia showing submucosal progression with direct invasion of the liver. A 71-year-old man was admitted with dysphagia. Esophagogastroscopy showed a protruding tumor covered with normal gastric mucosa in the anterior wall of the gastric cardia, although no abnormal findings were detected in the esophagus, including the esophagogastric junction. Serum SCC-related antigen level was elevated (6.6 ng/ml; normal level, less than 2.5 ng/ml). Endoscopic biopsy specimens taken from this tumor did not show malignant cells. Based on these findings, the preoperative diagnosis was a submucosal tumor of the stomach. Laparotomy was done; however, the tumor was not resected because it had direct invasion to the left lateral segment of the liver and adjacent tissues. As the tumor showed continuous bleeding from the stomach after surgery, total gastrectomy, combined with transhiatal lower esophagectomy, left lateral segmentectomy of the liver, splenectomy, and distal pancreatectomy was performed. Because histologic findings showed poorly or moderately differentiated SCC with direct invasion of the liver, the final diagnosis was SCC of the gastric cardia showing submucosal progression with hepatic invasion. Such a case of SCC of the gastric cardia showing submucosal progression is rare, and accurate preoperative diagnosis was very difficult. However, it may be important to consider SCC of the gastric cardia in such a situation.
authors.affiliation: Second Department of Surgery, Shinshu University School of Medicine, Matsumoto, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Koide
authors.forename: K
authors.initials: K
authors.lastname: Hanazaki
authors.forename: S
authors.initials: S
authors.lastname: Kajikawa
authors.forename: W
authors.initials: W
authors.lastname: Adachi
authors.forename: E
authors.initials: E
authors.lastname: Hara
authors.forename: J
authors.initials: J
authors.lastname: Amano
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000601:surgery; D002299:Cardia / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology; D008297:Male; D009361:Neoplasm Invasiveness; D013274:Stomach Neoplasms / Q000473:pathology* / Q000601:surgery