Receptor clustering and transmembrane signaling in T cells.
T cells are activated via engagement of their cell-surface receptors with molecules of the major histocompatibility complex (MHC) displayed on another cell surface. This process, which is a key step in the recognition of foreign antigens by the immune system, involves oligomerization of receptor components. Recent characterization of the T-cell response to soluble arrays of MHC-peptide complexes has provided insights into the triggering mechanism for T-cell activation.
Cochran
J R
JR
Dept of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Aivazian
D
D
Cameron
T O
TO
Stern
L J
LJ
D000818:Animals; D000938:Antigen-Presenting Cells; D002462:Cell Membrane / Q000378:metabolism*; D004789:Enzyme Activation; D006801:Humans; D008024:Ligands; D008213:Lymphocyte Activation; D008954:Models, Biological; D011485:Protein Binding; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000378:metabolism*
D008024:Ligands