title: Response of the stroke volume and blood pressure of young patients with nonobstructive hypertrophic cardiomyopathy to exercise.
abstract: Stroke volume (SV), cardiac output (CO) and systolic blood pressure (SBP) were measured during maximal symptom-limited bicycle exercise testing in 13 young patients (age, 11-26 years) with nonobstructive hypertrophic cardiomyopathy (HCM). SV was measured by impedance plethysmocardiography; %SVend, %COend, and %SBPend represent the ratio of the value at termination of the exercise to the respective value at rest. In all patients of HCM-I (the Cardiac Event Group, 3 patients) and 3 of HCM-II (the Non-Cardiac Event Group, 10 patients), the %SVend was less than 100%. The %SVend of HCM-I was significantly lower than the respective values of the HCM-II and Control groups. The %COend values of the HCM-I and HCM-II groups were each significantly lower than that of the Control. The %SBPend values of the HCM-I and HCM-II groups were each significantly lower than that of the Control. Among the HCM patients, the %SVend value was positively correlated with the %SBPend value. The patients who had more severe HCM had poorer exercise-induced increases in SV and SBP. These results suggest that sudden cardiac death in young HCM patients is associated with inhibition of the increase in SV upon exercise.
authors.affiliation: Department of Pediatrics, Yokohama City University Medical Center, Japan. kyasui@urahp.yokohama-cu.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Yasui
authors.forename: T
authors.initials: T
authors.lastname: Shibata
authors.forename: T
authors.initials: T
authors.lastname: Nishizawa
authors.forename: U
authors.initials: U
authors.lastname: Yokoyama
authors.forename: K
authors.initials: K
authors.lastname: Takigiku
authors.forename: T
authors.initials: T
authors.lastname: Sakon
authors.forename: K
authors.initials: K
authors.lastname: Yamaoka
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Iwamoto
authors.forename: K
authors.initials: K
authors.lastname: Sagawa
authors.forename: I
authors.initials: I
authors.lastname: Niimura
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D002302:Cardiac Output; D002648:Child; D016757:Death, Sudden, Cardiac / Q000453:epidemiology; D005080:Exercise Test; D017079:Exercise Tolerance; D005260:Female; D006323:Heart Arrest / Q000209:etiology; D006339:Heart Rate; D006346:Heart Septum / Q000000981:diagnostic imaging / Q000473:pathology; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology*; D007022:Hypotension / Q000209:etiology / Q000503:physiopathology; D008297:Male; D010992:Plethysmography, Impedance; D012306:Risk; D013318:Stroke Volume; D013575:Syncope / Q000209:etiology; D014463:Ultrasonography; D014655:Vascular Resistance