Mitochondrial DNA depletion, near-fatal metabolic acidosis, and liver failure in an HIV-infected child treated with combination antiretroviral therapy.
A child with controlled human immunodeficiency virus infection presented with neurologic deterioration, lactic acidosis, and organic aciduria. Muscle biopsy revealed abnormal mitochondrial (mt) morphology, reduced mt enzyme activities, and mtDNA depletion. After adjustment of antiretroviral therapy to a regimen free of nucleoside analogs, marked improvement was seen in clinical status and mt abnormalities.
Church
J A
JA
Departments of Pediatrics and Laboratory Medicine, Childrens Hospital Los Angeles, and the University of Southern California School of Medicine, Los Angeles, USA.
Mitchell
W G
WG
Gonzalez-Gomez
I
I
Christensen
J
J
Vu
T H
TH
Dimauro
S
S
Boles
R G
RG
D000138:Acidosis / Q000209:etiology*; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects* / Q000379:methods; D001706:Biopsy; D002675:Child, Preschool; D004272:DNA, Mitochondrial / Q000235:genetics / Q000378:metabolism*; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D017093:Liver Failure / Q000139:chemically induced*; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D013053:Spectrophotometry
D004272:DNA, Mitochondrial