Kinase chips hit the proteomics era.
Protein kinase chips, in which kinases are tested for their ability to phosphorylate immobilized substrates, have been developed and used to evaluate the protein kinases encoded by the yeast genome. This new technology promises to be a valuable addition to the biochemists' and cell biologists' arsenal for evaluating the substrate selectivity and function of protein kinases in cell signaling.
Williams
D M
DM
Dept of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Cole
P A
PA
D001665:Binding Sites; D001709:Biotechnology / Q000379:methods*; D004798:Enzymes / Q000032:analysis; D009154:Mutation; D020411:Oligonucleotide Array Sequence Analysis; D010766:Phosphorylation; D011485:Protein Binding; D011506:Proteins / Q000032:analysis*
D004798:Enzymes; D011506:Proteins