Risk of T-cell lymphomas in persons with AIDS.
Lymphomas in persons with AIDS are mostly B-cell types, but T-cell lymphomas have also been reported. We examined T-cell lymphoma risk in the 2-year period after AIDS onset by linking 302,834 adults with AIDS to cancer registry data. Of 6,788 cases of non-Hodgkin's lymphoma (NHL) with specified histologies, 96 (1.4%) were T-cell lymphomas. Assessment was based on clinical diagnosis and histology because T-cell marker data were inadequate, but when present, marker data supported the T-cell diagnosis. The relative risk of T-cell lymphoma, estimated by standardized incidence ratio, was 15.0 (95% confidence interval: 10.0--21.7). Risks were increased for all subtypes, including mycosis fungoides, peripheral lymphomas, cutaneous lymphomas, and adult T-cell leukemia/lymphoma (ATLL). HIV-related immunodeficiency could be important, but differences between the population developing AIDS and the general population (e. g., immigration from the Caribbean region for ATLL) might independently increase T-cell lymphoma risk.
Biggar
R J
RJ
Viral Epidemiology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20852, USA. Biggarb@epndce.nci.nih.gov
Engels
E A
EA
Frisch
M
M
Goedert
J J
JJ
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D017691:Caribbean Region / Q000208:ethnology; D004198:Disease Susceptibility; D005006:Ethnicity; D006801:Humans; D007150:Immunohistochemistry; D015994:Incidence; D016399:Lymphoma, T-Cell / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology; D008875:Middle Aged; D012042:Registries; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors