title: Baclofen overdose in two siblings.
abstract: Baclofen is a muscle relaxant used in both adults and children with neuromuscular disorders to control spasticity. In children, relatively few cases of overdose have been previously reported. We report two cases of baclofen overdose occurring in two siblings. One sibling with cerebral palsy was being treated with baclofen at the time of overdose. Both cases presented with severe respiratory depression requiring mechanical ventilation. Serum baclofen concentrations from both children were significantly elevated. We also review the published literature on baclofen overdose in children and adolescents. These cases emphasize the importance of warning parents about the potential toxicity of baclofen when prescribing the drug to a family member.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, University of Calgary, Alberta, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Chapple
authors.forename: D
authors.initials: D
authors.lastname: Johnson
authors.forename: R
authors.initials: R
authors.lastname: Connors
mesh_terms: D001418:Baclofen / Q000506:poisoning* / Q000627:therapeutic use; D002547:Cerebral Palsy / Q000188:drug therapy; D002648:Child; D002675:Child, Preschool; D062787:Drug Overdose; D005192:Family Health; D006801:Humans; D007223:Infant; D009125:Muscle Relaxants, Central / Q000506:poisoning* / Q000627:therapeutic use; D012120:Respiration Disorders / Q000139:chemically induced
chemical_list: D009125:Muscle Relaxants, Central; D001418:Baclofen