Effects of Scutellarein on diabetic rat aorta.
OBJECTIVE
To study the effect of Scutellarein (Scu) on the diabetic rat aorta.


METHODS
Contractile responses to phenylepherine and endothelium-dependent relaxation responses to acetylcholine (ACh) in rat aorta were investigated after streptozocin-induced 6-wk diabetes, Scu-treated streptozocin-induced diabetes, and in age-matched control in vitro.


RESULTS
1) Endothelium-dependent relaxation to ACh in diabetic rats was decreased (P < 0.01) compared with age-matched control. 2) Contractile responses to phenylepherine were increased (P < 0.01) in diabetic rats. 3) The dietary supplement of 0.5% Scu starting from 1-wk diabetes induction prevented endothelial dysfunction (P < 0.01), but the contractile responses to phenylepherine were further increased.


CONCLUSIONS
Scu prevented vascular endothelial dysfunction in diabetic rats, and also potentiated the contraction induced by phenylepherine.
Zhu
B H
BH
Department of Pharmacology, Sun Yat-Sen University of Medical Sciences, Guangzhou 510089, China. sszhu@gzsums.edu.cn
Guan
Y Y
YY
He
H
H
Lin
M J
MJ
D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology; D019659:Asteraceae / Q000737:chemistry; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D004730:Endothelium, Vascular / Q000502:physiology; D044950:Flavanones; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D014661:Vasoconstriction / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects*; D047310:Apigenin
D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; C458179:scutellarein; D047310:Apigenin