Mitochondrial permeability transition and oxidative stress.
Mitochondrial permeability transition (MPT) is a non-selective inner membrane permeabilization that may precede necrotic and apoptotic cell death. Although this process has a specific inhibitor, cyclosporin A, little is known about the nature of the proteinaceous pore that results in MPT. Here, we review data indicating that MPT is not a consequence of the opening of a pre-formed pore, but the consequence of oxidative damage to pre-existing membrane proteins.
Kowaltowski
A J
AJ
Departamento de Bioquímica, Instituto de Quimica, Universidade de São Paulo, São Paulo, SP, Brazil.
Castilho
R F
RF
Vercesi
A E
AE
D000818:Animals; D000975:Antioxidants / Q000378:metabolism / Q000494:pharmacology; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D007473:Ion Channels; D008565:Membrane Proteins / Q000187:drug effects / Q000502:physiology*; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D009243:NAD / Q000378:metabolism; D009336:Necrosis; D010084:Oxidation-Reduction / Q000187:drug effects; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D010710:Phosphates / Q000378:metabolism / Q000494:pharmacology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000037:antagonists & inhibitors / Q000378:metabolism
D000975:Antioxidants; D007473:Ion Channels; D008565:Membrane Proteins; D033681:Mitochondrial Membrane Transport Proteins; D000083162:Mitochondrial Permeability Transition Pore; D010710:Phosphates; D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D009243:NAD; D002118:Calcium