title: Influence of plant terpenoids on the permeability of mitochondria and lipid bilayers.
abstract: Five sesquiterpene alcohol esters of the carotane series, from plants of the genus Ferula, were investigated with regard to their capacity to modify the ion permeability of both planar lipid bilayers and mitochondria. These compounds are subdivided into two structural groups that differ in their effects on membrane permeability. Complex esters of sesquiterpene alcohols with aliphatic acids, which constituted the first group (lapidin and lapiferin), do not possess ionophoric properties. The second group comprised complex esters of sesquiterpene alcohols with aromatic acids (ferutinin, tenuferidin and ferutidin), all of which increase cation permeability of lipid bilayers and mitochondria in a dose-dependent manner. A pronounced selectivity of the terpenoid-modified membranes for divalent cations versus monovalent cations was found. Evidence of a carrier mechanism for terpenoid-induced ion transport is demonstrated. A tentative complex composed of a divalent cation with two molecules of membrane-active terpenoid is proposed.
authors.affiliation: Department of Biophysics, Tashkent State University, Uzbekistan.
authors.forename: A Y
authors.initials: AY
authors.lastname: Abramov
authors.forename: M V
authors.initials: MV
authors.lastname: Zamaraeva
authors.forename: A I
authors.initials: AI
authors.lastname: Hagelgans
authors.forename: R R
authors.initials: RR
authors.lastname: Azimov
authors.forename: O V
authors.initials: OV
authors.lastname: Krasilnikov
mesh_terms: D000818:Animals; D001565:Benzoates / Q000494:pharmacology; D001643:Bridged Bicyclo Compounds; D003508:Cycloheptanes; D004563:Electrochemistry; D007425:Intracellular Membranes / Q000737:chemistry / Q000187:drug effects*; D017136:Ion Transport; D007476:Ionophores / Q000494:pharmacology*; D008051:Lipid Bilayers / Q000737:chemistry*; D008930:Mitochondria, Liver / Q000187:drug effects; D008958:Models, Molecular; D015394:Molecular Structure; D010539:Permeability; D010944:Plants / Q000737:chemistry; D051381:Rats; D012717:Sesquiterpenes / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D001565:Benzoates; D001643:Bridged Bicyclo Compounds; D003508:Cycloheptanes; D007476:Ionophores; D008051:Lipid Bilayers; D012717:Sesquiterpenes; D013729:Terpenes; C111068:4-oxy-6-(4-oxybezoyloxy)dauc-8,9-en; C090978:lapidin