title: The search for congenital malformations in newborns with fetal cocaine exposure.
abstract: BACKGROUND
  The association between prenatal cocaine exposure and congenital anomalies is not definitive.
  
  
  OBJECTIVE
  To determine whether prenatal cocaine exposure results in an increased number or identifiable pattern of abnormalities.
  
  
  METHODS
  A prospective, longitudinal cohort enrolled between 1991 and 1993.
  
  
  METHODS
  Rural public health population delivering at a regional tertiary medical center.
  
  
  METHODS
  Two hundred seventy-two offspring of 154 prenatally identified crack/cocaine users and 154 nonusing controls were matched on race, parity, location of prenatal care (that related to level of pregnancy risk), and socioeconomic status. Drug use was determined through repeated in-depth histories and urine screens. Infants not examined within 7 days of birth were excluded.
  
  
  METHODS
  Assessments were made by experienced examiners masked to maternal drug history. Included were 16 anthropometric measurements and a checklist of 180 physical features defined and agreed upon in advance.
  
  
  RESULTS
  There were no differences on major risk variables between the included and excluded infants. There were significantly more premature infants in the cocaine-exposed group. Cocaine-exposed infants were significantly smaller in birth weight, length, and head circumference but did not differ on remaining anthropometric measurements. There was no difference in type or number of abnormalities identified between the exposed and nonexposed groups. There was no relationship between amount or timing of exposure and any of the outcomes.
  
  
  CONCLUSIONS
  This prospective, large-scale, blinded, systematic evaluation for congenital anomalies in prenatally cocaine-exposed children did not identify an increased number or consistent pattern of abnormalities.
authors.affiliation: Department of Pediatrics, University of Florida, Gainesville, Florida 32610, USA.behnkem@peds.ufl.edu
authors.forename: M
authors.initials: M
authors.lastname: Behnke
authors.forename: F D
authors.initials: FD
authors.lastname: Eyler
authors.forename: C W
authors.initials: CW
authors.lastname: Garvan
authors.forename: K
authors.initials: K
authors.lastname: Wobie
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D000328:Adult; D000704:Analysis of Variance; D019970:Cocaine-Related Disorders / Q000150:complications*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008137:Longitudinal Studies; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011256:Pregnancy Outcome; D011297:Prenatal Exposure Delayed Effects