Uveitis: what do we know and how does it help?
Uveitis essentially means intraocular inflammation and encompasses a wide variety of different disorders. This includes both mild and severe types of inflammation affecting different parts of the eye. Histologically, all uveitis is characterized by an influx of lymphocytes into the affected tissue. In all types these lymphocytes are predominantly of the CD4 type, whether the disorder is mild or blinding, giving no clue as to why. New studies comparing cells in ocular fluids taken from inflamed eyes with different types of inflammation have, for the first time, shown a difference in the cytokine profile, so that in visually benign disease interleukin 10 levels are higher than in those which are blinding.The potential for this in terms of therapy is discussed.
Lightman
S
S
Institute of Ophthalmology and Moorfields Eye Hospital, London, UK. s.lightman@ucl.ac.uk
D000818:Animals; D001082:Aqueous Humor / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D014605:Uveitis / Q000150:complications / Q000276:immunology / Q000473:pathology / Q000628:therapy; D014822:Vitreous Body / Q000276:immunology / Q000473:pathology