Articular cartilage transplantation. Current and future limitations and solutions.
The ultimate goal of replacing cartilage with a bioengineered graft, autologous graft, or allograft is to replace the damaged articulating surface with tissue containing the anatomical, biomechanical, and functional properties of native articular cartilage, which will have resultant satisfactory clinical outcome. For transplanted articular cartilage to obtain the original histologic arrangement of hyaline cartilage with secure incorporation into host tissue, progressive integrated multidisciplinary research must continue. Although autologous chondrocyte transplantation of the talus is not yet FDA approved, this technique may provide the surgeons with a cutting-edge method to treat patients with nondegenerative osteochondral lesions of the talus and possibly other articulating joints of the foot.
Hayes
D W
DW
Department of Podiatric Surgery and Traumatology, Broadlawns Medical Center, Des Moines, Iowa, USA.
Averett
R K
RK
D000843:Ankle Joint / Q000601:surgery*; D002357:Cartilage Diseases / Q000601:surgery*; D002358:Cartilage, Articular / Q000166:cytology / Q000601:surgery* / Q000637:transplantation*; D019902:Chondrocytes / Q000637:transplantation*; D006801:Humans; D013640:Tarsal Joints / Q000601:surgery*; D014180:Transplantation / Q000639:trends