title: Loss of heterozygosity or intragenic mutation, which comes first?
authors.affiliation: Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland, USA. rwilentz@mail.jhmi.edu
authors.forename: R E
authors.initials: RE
authors.lastname: Wilentz
authors.forename: P
authors.initials: P
authors.lastname: Argani
authors.forename: R H
authors.initials: RH
authors.lastname: Hruban
mesh_terms: D002886:Chromosomes, Human, Pair 17 / Q000235:genetics; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics; D006801:Humans; D019656:Loss of Heterozygosity; D018895:Microsatellite Repeats; D009154:Mutation; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000473:pathology; D051901:Smad4 Protein; D015534:Trans-Activators / Q000235:genetics; D016159:Tumor Suppressor Protein p53 / Q000235:genetics
chemical_list: D004268:DNA-Binding Proteins; C497796:SMAD4 protein, human; D051901:Smad4 Protein; D015534:Trans-Activators; D016159:Tumor Suppressor Protein p53