Polyamines in the basal ganglia of human brain. Influence of aging and degenerative movement disorders.
The distribution of polyamines in the human basal ganglia was examined, using dansyl-derivatives and high pressure liquid chromatography with fluorimetric detection. A heterogeneous distribution of putrescine, spermidine (SD) and spermine (SM) was observed in control brains. A consistent negative correlation between SD and SM content and age was found in different brain areas. These results suggest an involvement of polyamines in age-related changes occurring in white-matter. When the influence of degenerative movement disorders -Parkinson's disease, Huntington's disease (HD) and progressive supranuclear palsy- was analyzed, significant changes were observed only in HD, where a decrease in the concentration of SM was found in the putamen. These results suggest that in advanced stages of neurodegenerative processes, polyamines maintain their regulation. Only in the presence of severe atrophy, SM concentration is reduced.
Vivó
M
M
Department of Neurochemistry, Institut d'Investigacions Biomèdiques de Barcelona (CSIC-IDIBAPS), c/Rosselló 161, 6th floor. 08036, Barcelona, Spain.
de Vera
N
N
Cortés
R
R
Mengod
G
G
Camón
L
L
Martínez
E
E
D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000378:metabolism*; D000704:Analysis of Variance; D001479:Basal Ganglia / Q000378:metabolism*; D015317:Biogenic Polyamines / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019636:Neurodegenerative Diseases / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism
D015317:Biogenic Polyamines; D013096:Spermine; D013095:Spermidine; D011700:Putrescine