title: Childhood optic atrophy.
abstract: OBJECTIVE
  To determine the causes, and relative incidence of the common causes, of optic nerve atrophy in children under 10 years old and to compare prevalent aetiologies with those given in previous studies.
  
  
  METHODS
  The Wilmer Information System database was searched to identify all children, diagnosed between 1987 and 1997 with optic atrophy, who were under 10 years old at diagnosis. The medical records of these children were reviewed retrospectively
  
  
  RESULTS
  A total of 272 children were identified, Complications from premature birth were the most frequent aetiology of optic atrophy (n = 44, 16%); 68% of these premature infants having a history of intraventricular haemorrhage. Tumour was the second most common aetiology (n = 40, 15%). The most frequent tumour was pilocytic astrocytoma (50%), followed by craniopharyngioma (17%). Hydrocephalus, unrelated to tumour, was the third most common aetiology (n = 26, 10%). In 114 cases (42%), the cause of optic atrophy became manifest in the perinatal period and/or could be attributed to adverse events in utero. A cause was not determined in 4% of cases.
  
  
  CONCLUSIONS
  In the last decade, prematurity and hydrocephalus appear to have become important causes of optic atrophy in childhood. This trend is probably the result of improved survival of infants with extremely low birth weight.
authors.affiliation: The Wilmer Ophthalmological Institute at Johns Hopkins Hospital, Division of Paediatric Ophthalmology and Strabismus, Baltimore, Maryland 21287-9028, USA. vmudgil@jhmi.edu
authors.forename: A V
authors.initials: AV
authors.lastname: Mudgil
authors.forename: M X
authors.initials: MX
authors.lastname: Repka
mesh_terms: D015142:Baltimore / Q000453:epidemiology; D001932:Brain Neoplasms / Q000150:complications; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000150:complications; D015994:Incidence; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000473:pathology; D008297:Male; D009896:Optic Atrophy / Q000453:epidemiology* / Q000209:etiology; D015995:Prevalence; D012189:Retrospective Studies; D012307:Risk Factors