Isolation of virus-cell fusion inhibitory components from Eugenia caryophyllata.
The fractionation of Eugenia caryophyllata (Myrtaceae) guided by the syncytia formation inhibition assay led to the isolation of four tannins (eugeniin, casuarictin, 1,3-di-O-galloyl-4,6-(S)-hexahydroxydiphenoyl-beta-D-glucopyranose, and tellimagrandin I), and two chromones (biflorin and isobiflorin). Among the isolated compounds, tellimagrandin (4) showed a significantly high inhibitory activity on the syncytia formation with an IC50 value of 16.12 +/- 1.98 micrograms/ml.
Kim
H J
HJ
Lee
J S
JS
Woo
E R
ER
Kim
M K
MK
Yang
B S
BS
Yu
Y G
YG
Park
H
H
Lee
Y S
YS
D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015726:Giant Cells / Q000187:drug effects* / Q000378:metabolism; D015699:HIV Envelope Protein gp120 / Q000187:drug effects; D015497:HIV-1 / Q000187:drug effects*; D008561:Membrane Fusion / Q000187:drug effects; D010936:Plant Extracts / Q000737:chemistry; D018520:Plant Shoots / Q000737:chemistry; D019685:Rosales / Q000737:chemistry*; D013634:Tannins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D002867:Chromones; D015699:HIV Envelope Protein gp120; D010936:Plant Extracts; D013634:Tannins