title: The cellular neurobiology of depression.
abstract: Major depressive disorders, long considered to be of neurochemical origin, have recently been associated with impairments in signaling pathways that regulate neuroplasticity and cell survival. Agents designed to directly target molecules in these pathways may hold promise as new therapeutics for depression.
authors.affiliation: Laboratory of Molecular Pathophysiology, National Institute of Mental Health, Bethesda, Maryland, USA. manjih@intra.nimh.nih.gov
authors.forename: H K
authors.initials: HK
authors.lastname: Manji
authors.forename: W C
authors.initials: WC
authors.lastname: Drevets
authors.forename: D S
authors.initials: DS
authors.lastname: Charney
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use; D002470:Cell Survival / Q000187:drug effects; D003866:Depressive Disorder / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D005938:Glucocorticoids / Q000494:pharmacology; D009473:Neuronal Plasticity / Q000187:drug effects; D015398:Signal Transduction
chemical_list: D000928:Antidepressive Agents; D005938:Glucocorticoids