Lamivudine and glycyrrhizin for treatment of chemotherapy-induced hepatitis B virus (HBV) hepatitis in a chronic HBV carrier with non-Hodgkin lymphoma.
We report a chronic hepatitis B virus (HBV) carrier with non-Hodgkin lymphoma (NHL) who developed HBV hepatitis following conventional dose chemotherapy and was successfully treated with lamivudine and glycyrrhizin. A 55 year-old male patient with primary testicular NHL (diffuse large B-cell type) relapsed. During the salvage chemotherapy, the patient showed elevated serum levels of transaminase and HBV-DNA due to HBV reactivation. Treatment with lamivudine, an antiviral nucleoside analog, was started at a dose of 100mg/day. Shortly after the treatment the HBV-DNA level was suppressed, and sustained elevation of transaminase levels were normalized after additional treatment with glycyrrhizin. This experience suggests that lamivudine combined with glycyrrhizin may be effective for controlling HBV replication and treating chemotherapy-induced HBV hepatitis in chronic HBV carriers with NHL.
Matsuo
K
K
Second Department of Internal Medicine; Okayama University, Medical School, 2-5-1 Shikata-cho, Okayama, Japan. suo@aichigw.aichi-cc.pref.aichi.jp
Takenaka
K
K
Shimomura
H
H
Fujii
N
N
Shinagawa
K
K
Kiura
K
K
Harada
M
M
D019380:Anti-HIV Agents / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D002908:Chronic Disease; D004279:DNA, Viral / Q000097:blood; D004359:Drug Therapy, Combination; D019695:Glycyrrhizic Acid / Q000008:administration & dosage*; D006509:Hepatitis B / Q000139:chemically induced* / Q000188:drug therapy*; D006515:Hepatitis B virus / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D019259:Lamivudine / Q000008:administration & dosage*; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000821:virology*; D008297:Male; D008875:Middle Aged; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage*; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000821:virology; D014775:Virus Activation / Q000187:drug effects
D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine; D019695:Glycyrrhizic Acid