Nanoscale biogenic iron oxides and neurodegenerative disease.
One of the characteristics of many neurodegenerative diseases is the disruption of normal iron homeostasis in the brain. Recent experimental work indicates that nanoscale magnetic biominerals (primarily magnetite and maghemite) may be associated with senile plaques and tau filaments found in brain tissue affected by these diseases. These findings have important implications for our understanding of the role of iron in neurodegenerative disease as well as profound implications for their causes. In addition, the presence of biogenic magnetite in affected tissue should also provide improved mechanisms for early detection through the modification of MRI pulse sequences.
Dobson
J
J
Centre for Science and Technology in Medicine, Department of Biomedical Engineering and Medical Physics, Keele University, Thornburrow Drive, Hartshill, Stroke-on-Trent ST4 7QB, UK. jdobson@keele.ac.uk
D005290:Ferric Compounds / Q000378:metabolism*; D005293:Ferritins / Q000378:metabolism; D052203:Ferrosoferric Oxide; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D008853:Microscopy / Q000379:methods; D019636:Neurodegenerative Diseases / Q000175:diagnosis / Q000378:metabolism*; D010087:Oxides / Q000378:metabolism; D010316:Particle Size; D058225:Plaque, Amyloid / Q000378:metabolism; D016875:tau Proteins / Q000378:metabolism
D005290:Ferric Compounds; D010087:Oxides; D016875:tau Proteins; C000499:ferric oxide; D005293:Ferritins; D007501:Iron; D052203:Ferrosoferric Oxide