Association between the SDF1-3'A allele and high levels of CD34(+) progenitor cells mobilized into peripheral blood in humans.
Some patients unexpectedly fail to mobilize sufficient numbers of haematopoietic progenitor cells (HPCs) into the peripheral blood for autologous transplantation. Considering the important role of the chemokine stromal cell-derived factor 1 (SDF-1) in HPC homing, we investigated a possible relationship between SDF1 gene polymorphism and HPC mobilization capacity in 63 patients with malignancy. Some 67% of the good mobilizers (> or = 50 CD34(+) cells/microl) and only 36% of the intermediate/poor mobilizers were SDF1-3'A allele carriers (P = 0.032). In multivariate analysis, the presence of the SDF1-3'A allele was the only factor predictive of good CD34(+) cell mobilization (P = 0.025). This is the first report showing the involvement of genetic factors for HPC mobilization in humans and suggests a significant role for SDF-1 in this process.
Benboubker
L
L
UPRES-EA Haematopoietic Cells, Haemostasis and Transplantation, University of Tours, France.
Watier
H
H
Carion
A
A
Georget
M T
MT
Desbois
I
I
Colombat
P
P
Bardos
P
P
Binet
C
C
Domenech
J
J
D000328:Adult; D000483:Alleles; D018952:Antigens, CD34; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics*; D005260:Female; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000601:surgery; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000235:genetics / Q000276:immunology / Q000601:surgery; D006801:Humans; D008223:Lymphoma / Q000235:genetics / Q000276:immunology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology / Q000601:surgery; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D013234:Stem Cells / Q000276:immunology*
D018952:Antigens, CD34; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC