Molecular piracy of Kaposi's sarcoma associated herpesvirus.
Kaposi's Sarcoma associated Herpesvirus (KSHV) is the most recently discovered human tumor virus and is associated with the pathogenesis of Kaposi's sarcoma, primary effusion lymphoma, and Multicentric Casttleman's disease. KSHV contains numerous open reading frames with striking homology to cellular genes. These viral gene products play a variety of roles in KSHV-associated pathogenesis by disrupting cellular signal transduction pathways, which include interferon-mediated anti-viral responses, cytokine-regulated cell growth, apoptosis, and cell cycle control. In this review, we will attempt to cover our understanding of how viral proteins deregulate cellular signaling pathways, which ultimately contribute to the conversion of normal cells to cancerous cells.
Choi
J
J
Department of Microbiology and Molecular Genetics, Tumor Virology Division, New England Regional Primate Research Center, Harvard Medical School, 1 Pine Hill Drive, Southborough, MA 01772, USA.
Means
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Damania
B
B
Jung
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JU
D000818:Animals; D017209:Apoptosis; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D019143:Evolution, Molecular; D005814:Genes, Viral / Q000235:genetics; D000882:Haplorhini / Q000821:virology; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism*; D015395:Histocompatibility Antigens Class I / Q000276:immunology / Q000378:metabolism; D006801:Humans; D018716:Molecular Mimicry; D012514:Sarcoma, Kaposi / Q000378:metabolism / Q000821:virology; D015398:Signal Transduction; D014764:Viral Proteins / Q000235:genetics / Q000276:immunology / Q000378:metabolism
D015395:Histocompatibility Antigens Class I; D014764:Viral Proteins