Expression of GAP-43 in the retina of rats following protracted illumination.
Distribution of GAP-43 was studied in the retinas of rats after continuous illumination followed by different darkness periods. GAP-43 immunoreactivity was maximum in regenerating outer photoreceptor segments of rats kept in total darkness for 10 days, while in the inner plexiform layer, immunoreactivity was maximum immediately after illumination. Changes in GAP-43 expression could participate in retinal repair/regeneration after light-induced damage.
López-Costa
J J
JJ
Instituto de Biología Celular y Neurociencia 'Prof. E. De Robertis', Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, P 3, (CP 1121), Buenos Aires, Argentina.
Goldstein
J
J
Mangeaud
M
M
Saavedra
J P
JP
D000818:Animals; D003624:Darkness; D019922:GAP-43 Protein / Q000378:metabolism*; D007150:Immunohistochemistry; D008027:Light; D009416:Nerve Regeneration / Q000502:physiology; D020419:Photoreceptor Cells, Vertebrate / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012160:Retina / Q000378:metabolism* / Q000528:radiation effects*; D013997:Time Factors; D014018:Tissue Distribution
D019922:GAP-43 Protein