[Changes of activities of MLCK and dephosphatase in different arterial vessels from hypertensive rats].
The changes of activities of myosin light chain kinase (MLCK) and Ca2+/CaM-PP in different arterial vessels from hypertensive and normotensive rats were studied. The results were as follows. The MLCK activity of different arteries of spontaneous hypertensive rats (SHR) was different with the order of aorta (A) >> caudal artery (CA) >> mesenteric artery (MA), while in WKY rats the order of activity among different arteries is A << CA and MA and MA Ca2+/CaM-PP is obviously higher than in SHR. In renal hypertensive rats the activities of Ca2+/CaM-PP in different arteries are not quite different from those of the Wistar rats. The above results suggest that higher activities of MLCK or/and lower activity might be related to vasocontraction and hypertension.
Sun
W
W
Department of Physiology, Institute of Basic Medical Sciences, School of Basic Medicine, CAMS and PUMC, Beijing 100005.
Wen
Y Y
YY
Wu
G Y
GY
D000818:Animals; D001011:Aorta / Q000201:enzymology; D001158:Arteries / Q000201:enzymology; D006973:Hypertension / Q000201:enzymology*; D006978:Hypertension, Renovascular / Q000201:enzymology; D008638:Mesenteric Arteries / Q000201:enzymology; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D009219:Myosin-Light-Chain Kinase / Q000378:metabolism*; D010749:Phosphoprotein Phosphatases / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D017208:Rats, Wistar
D009219:Myosin-Light-Chain Kinase; C110531:calmodulin dependent protein kinase II phosphatase; D010749:Phosphoprotein Phosphatases