title: Insulin, leptin, IGF-I and insulin-dependent protein concentrations after insulin-sensitizing therapy in obese women with polycystic ovary syndrome.
abstract: OBJECTIVE
  To determine the clinical, hormonal and biochemical effect of 4-5 months of insulin-sensitizing therapy (hypocaloric diet+metformin) in obese patients with polycystic ovary syndrome (PCOS).
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Twenty-three obese patients with PCOS, 19 obese patients without menstrual disturbances and 11 healthy control women were recruited from the Department of Endocrinology and Endocrine Gynecology, Medical Academy, Bialystok, Poland. Obese patients received 500 mg metformin together with hypocaloric diet three times daily for 4-5 months, after baseline study. The clinical parameters, menstrual pattern and serum concentrations of insulin, leptin, IGF-I, insulin-dependent proteins (sex hormone-binding protein (SHBG), insulin-like growth factor-binding protein-1 (IGFBP-1)), gonadotropins and sex steroids were determined before and after treatment.
  
  
  RESULTS
  In the baseline study, obese patients with PCOS had significantly higher insulin, testosterone and LH concentrations in comparison with the other groups. The serum leptin, IGF-I, IGFBP-1 and SHBG were not different between the two groups of obese patients, but there was a significant difference in comparison with the control group. After metformin therapy a significant reduction in BMI, % of body fat and leptin concentration were observed in both groups of obese patients. Fasting insulin, testosterone and LH concentrations decreased significantly only in the PCOS group. Six out of 11 patients in the PCOS group had more regular menstrual cycles; two patients conceived.
  
  
  CONCLUSIONS
  Insulin-sensitizing therapy could be considered as an additional therapeutic option in obese women with PCOS.
authors.affiliation: Department of Endocrinology, Medical Academy, Biaystok, Poland. amb_endo@poczta.onet.pl
authors.forename: I
authors.initials: I
authors.lastname: Kowalska
authors.forename: M
authors.initials: M
authors.lastname: Kinalski
authors.forename: M
authors.initials: M
authors.lastname: Straczkowski
authors.forename: S
authors.initials: S
authors.lastname: Wolczyski
authors.forename: I
authors.initials: I
authors.lastname: Kinalska
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D020738:Leptin / Q000097:blood*; D008687:Metformin / Q000627:therapeutic use; D009765:Obesity / Q000097:blood* / Q000150:complications; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000188:drug therapy / Q000628:therapy*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D018970:Insulin-Like Growth Factor Binding Protein 1; D020738:Leptin; D007334:Insulin-Like Growth Factor I; D008687:Metformin