title: High-grade lymphoma mimicking bone crisis in Gaucher's disease.
abstract: A 33-year-old woman with type 1 Gaucher's disease developed painful swelling of her right tibia. Initial diagnostics suggested a typical bone crisis. However, clinical course and subsequent imaging pointed to malignant disease, which was specified as high-grade lymphoma. Chemotherapy was applied together with enzyme replacement and resulted in complete remission of the lymphoma. We conclude that osseous lesions, although suggestive of common manifestations of Gaucher's disease, should be discriminated very carefully from neoplastic infiltration to maintain curative treatment options.
authors.affiliation: Department of Haematology/Oncology, University of Tübingen, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Manz
authors.forename: R
authors.initials: R
authors.lastname: Riessen
authors.forename: L
authors.initials: L
authors.lastname: Poll
authors.forename: B
authors.initials: B
authors.lastname: Dohmen
authors.forename: E
authors.initials: E
authors.lastname: Kaiserling
authors.forename: W
authors.initials: W
authors.lastname: Krück
authors.forename: M
authors.initials: M
authors.lastname: Laniado
authors.forename: L
authors.initials: L
authors.lastname: Kanz
authors.forename: C
authors.initials: C
authors.lastname: Denzlinger
mesh_terms: D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis / Q000556:secondary; D003937:Diagnosis, Differential; D005260:Female; D005776:Gaucher Disease / Q000150:complications*; D006801:Humans; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000150:complications* / Q000175:diagnosis*; D008279:Magnetic Resonance Imaging; D013977:Tibia / Q000000981:diagnostic imaging / Q000473:pathology*; D014055:Tomography, Emission-Computed