New taxane analogues from the needles of Taxus canadensis.
Eight minor taxanes have been identified for the first time in Taxus canadensis needles. Four of these metabolites are new taxane analogues: 7-acetyl-10-deacetyltaxol (1), 2'-acetyl-7-epi-cephalomannine (2), 10-deacetyl-10-oxo-7-epi-cephalomannine (3), and 10-acetylglycollylbaccatin VI (4).
Zhang
J
J
Human Health Research Center, INRS-Institut Armand-Frappier, Université du Québec, 531 Boulevard des Prairies, Laval, Québec, Canada, H7V 1 B7.
Sauriol
F
F
Mamer
O
O
You
X L
XL
Alaoui-Jamali
M A
MA
Batist
G
G
Zamir
L O
LO
D000230:Adenocarcinoma / Q000473:pathology; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000473:pathology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014197:Trees; D014407:Tumor Cells, Cultured
D000470:Alkaloids