Signal transduction pathways leading to cell cycle arrest and apoptosis induced by DNA topoisomerase poisons.
In this overview, I have summarized the important pathways of stress-induced signal transduction: stabilization and activation of p53 playing a central role in stress-induced cell cycle checkpoint and apoptosis, and activation of ASK1-JNK/p38 pathway often induced by a variety of stress stimuli, which appears to be essentially required for apoptosis to follow.
Andoh
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Soka University Faculty of Engineering, Hachioji, Tokyo, Japan. andoh@t.soka.ac.jp
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D017209:Apoptosis / Q000187:drug effects*; D002453:Cell Cycle / Q000187:drug effects*; D004249:DNA Damage; D004791:Enzyme Inhibitors / Q000633:toxicity*; D006801:Humans; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors