title: Burkholderia cepacia: current clinical issues, environmental controversies and ethical dilemmas.
abstract: Burkholderia cepacia is a plant phytogen and is known as a hardy and versatile organism. Over the past two decades it has emerged as a pathogen in the cystic fibrosis (CF) community, with devastating effects. Pulmonary colonisation can lead to an accelerated decline in lung function. In some cases, it causes a rapid and progressive pneumonic illness termed "cepacia syndrome", which is untreatable and fatal. B. cepacia is inherently resistant to multiple antibiotics and highly transmissible and virulent strains have been identified. CF patients colonised with the organism have to be segregated from their peers to try to prevent cross-infection. However, the pathogenicity of B. cepacia is not limited to CF. Other groups, such as individuals with chronic granulomatous disease and immunocompromised patients are vulnerable and it has caused disease in healthy individuals. However, the agricultural and petrochemical industries are attempting to exploit properties of B. cepacia for use as a biopesticide and biodegradation agent. This article provides an up to date review of clinically based literature on the Burkholderia cepacia complex, highlighting clinical management issues for both cystic fibrosis and non-cystic fibrosis patients. The article also addresses the potential conflict between medicine and agriculture on plans to reintroduce strains of Burkholderia cepacia back into the environment.
authors.affiliation: Manchester Adult Cystic Fibrosis Unit, Wythenshawe Hospital, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Jones
authors.forename: M E
authors.initials: ME
authors.lastname: Dodd
authors.forename: A K
authors.initials: AK
authors.lastname: Webb
mesh_terms: D019121:Burkholderia Infections / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000635:transmission; D016956:Burkholderia cepacia / Q000302:isolation & purification / Q000472:pathogenicity; D003428:Cross Infection / Q000635:transmission; D003550:Cystic Fibrosis / Q000150:complications / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D010572:Pest Control, Biological; D014774:Virulence