Talking tumours: histories from sequences.
The history of a tumour is currently inferred from its morphology. However, progression may be variable between similar appearing tumours, and some critical events may be difficult to see. It has become increasingly apparent that histories are also written within sequences. Every tumour likely records its own progression within its genome. In the future, it may be possible to read the past based on these sequences. A critical issue is whether these autobiographies will recapitulate morphology or whether they reveal unexpected ghosts.
Shibata
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Norris Cancer Center, University of Southern California School of Medicine, Los Angeles 90033, USA. dshibata@hsc.usc.edu
D000236:Adenoma / Q000235:genetics; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics; D018450:Disease Progression; D006801:Humans; D016296:Mutagenesis; D009369:Neoplasms / Q000235:genetics*