Schistosoma mansoni: inflammatory foci around larvae in the peritoneal cavity of naive mice is radiosensitive.
Innate attack to Schistosoma mansoni cercariae was evaluated in irradiated mice. It was observed that 70% of the larvae from mice sacrificed one day after whole body irradiation with 400 or 800 rads were surrounded by cluster reactivities, without difference from controls. Differences were apparent on day 5 after irradiation with sub lethal (400 rads) or lethal doses (800 rads) suggesting that innate defence to infection take at least 5 days to be affected by low dose whole-body radiation.
Melo
A L
AL
Departamento de Parasitologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, MG, 30161-970, Brasil. aldemelo@icb.ufmg.br
Chamone
M
M
D000818:Animals; D002448:Cell Adhesion / Q000528:radiation effects; D005720:Gamma Rays; D007274:Injections, Intraperitoneal; D007814:Larva / Q000528:radiation effects; D008264:Macrophages / Q000502:physiology / Q000528:radiation effects; D008297:Male; D051379:Mice; D010529:Peritoneal Cavity / Q000469:parasitology*; D012550:Schistosoma mansoni / Q000528:radiation effects*; D014916:Whole-Body Irradiation