title: mRNA turnover.
abstract: Nuclear RNA-binding proteins can record pre-mRNA processing events in the structure of messenger ribonucleoprotein particles (mRNPs). During initial rounds of translation, the mature mRNP structure is established and is monitored by mRNA surveillance systems. Competition for the cap structure links translation and subsequent mRNA degradation, which may also involve multiple deadenylases.
authors.affiliation: Wellcome Trust Centre for Cell Biology, ICMB, University of Edinburgh, Kings' Buildings, Edinburgh EH9 3JR, UK. pmitch@holyrood.ed.ac.uk
authors.forename: P
authors.initials: P
authors.lastname: Mitchell
authors.forename: D
authors.initials: D
authors.lastname: Tollervey
mesh_terms: D017398:Alternative Splicing / Q000502:physiology*; D000818:Animals; D010442:Peptide Chain Initiation, Translational / Q000502:physiology; D014176:Protein Biosynthesis / Q000502:physiology; D012322:RNA Precursors / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D012260:Ribonucleases / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism*; D015003:Yeasts / Q000378:metabolism
chemical_list: D012322:RNA Precursors; D012333:RNA, Messenger; D012261:Ribonucleoproteins; C026452:messenger ribonucleoprotein; D012260:Ribonucleases