[Study on liver targeting and sustained release hydroxycamptothecin polybutylcyanoacrylate nanoparticles].
The liver targeting and sustained release hydroxycamptothecin polybutylcyanoacrylate nanoparticles (HCPT-PBCA-NP) which were wrapped up with ployvinylpyrrolidone(PVP) were prepared by adsorption-enwrapping method. The morphology, size and size distribution, drug loading, release characteristics in vitro, distribution and pharmacokinetic parameters in animals of the PVP-HCPT-PBCA-NP were studied. The results showed that the average diameter was 81.2 nm, drug loading was 1.22%. The release characteristics in vitro was in accord with Higuchi equation: Q = 0.0615 + 0.0940 square root of t.64.5% of the HCPT were concentrated in liver 15 min after iv PVP-HCPT-PBCA-NP. The plasma drug concentration-time curve of the HCPT in 5 rabbits was fitted to a two-compartment open model. The Vc was 3.548 L; T1/2 was 146.99 h; CL was 0.178 L.h-1. The method of preparation presented in this paper seems to have important reference value for the preparation of PBCA-NP of the insoluble drugs both in water and in oil.
Zhang
Z R
ZR
School of Pharmacy, West China University of Medical Sciences, Chengdu 610041.
Lu
W
W
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005260:Female; D008099:Liver / Q000378:metabolism*; D008297:Male; D051379:Mice; D011817:Rabbits; D011897:Random Allocation
D000972:Antineoplastic Agents, Phytogenic; D003692:Delayed-Action Preparations; D002166:Camptothecin