Transfer of human herpesvirus 6 and 7 antibodies from mothers to their offspring.
Placental transfer of maternal human herpesvirus (HHV) 6 and HHV 7 antibodies to infants was examined simultaneously in 69 paired plasma samples by an indirect immunofluorescence assay. All the mothers had antibodies to both viruses. The mean HHV 6 and HHV 7 antibody titers of infants were significantly higher than those of the mothers. The mean ratio of cord blood antibody titer to the maternal titer for both viruses was 1.89, suggesting active transport by placenta.
Ohashi
M
M
Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, Japan.
Ihira
M
M
Suzuki
K
K
Suga
S
S
Asano
Y
Y
Yoshikawa
T
T
Saito
Y
Y
Sakui
H
H
D000914:Antibodies, Viral / Q000097:blood*; D005077:Exanthema Subitum / Q000097:blood / Q000151:congenital / Q000635:transmission; D005260:Female; D005312:Fetal Blood / Q000276:immunology* / Q000821:virology; D019084:Fluorescent Antibody Technique, Indirect; D006566:Herpesviridae Infections / Q000097:blood / Q000151:congenital* / Q000635:transmission*; D015654:Herpesvirus 6, Human / Q000276:immunology; D016199:Herpesvirus 7, Human / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology* / Q000821:virology
D000914:Antibodies, Viral