[Neural differentiation of Wnt-1 overexpression P19 cells].
Wnt-1 gene plays important roles during the development of the mouse central neural system. and shown a transient expression during neuronal differentiation of P19 EC cells. We transfected Wnt-1 gene into P19 cells and found the Wnt-1 transfected cells could differentiate into neurons without the induction of RA. However, MASH-1, a crucial gene for the early neural differentiation, was expressed later than P19 cells induced by RA.
Yang
J
J
Shanghai Institute of Biochemistry, Chinese Academy of Sciences, Shanghai 200031.
Sun
H
H
Bian
W
W
Jing
N H
NH
D000818:Animals; D051792:Basic Helix-Loop-Helix Proteins; D001921:Brain / Q000196:embryology*; D018236:Carcinoma, Embryonal / Q000473:pathology; D002454:Cell Differentiation; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000096:biosynthesis; D004330:Drosophila / Q000235:genetics; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009474:Neurons / Q000166:cytology; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis*; D013736:Testicular Neoplasms / Q000473:pathology; D014157:Transcription Factors / Q000096:biosynthesis; D014162:Transfection; D014407:Tumor Cells, Cultured; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins
D051792:Basic Helix-Loop-Helix Proteins; D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins; C499317:Ascl1 protein, mouse; C495246:Wnt1 protein, mouse