title: [Level of cyclic AMP during induction of alternative oxidase in Yarrowia lipolytica yeast cells].
abstract: The effect of cyanide, antimycin A, ethanol, and acetate on the induction of alternative oxidase in the yeast Yarrowia lipolytica VKM Y-155 sensitive to cyanide, in the presence of the aforementioned compounds led to the development of cyanide-resistant respiration, which could be suppressed by benzohydroxamic acid, an inhibitor of alternative oxidases. The incubation of cells with cyanide, ethanol, or acetate raised the intracellular pool of cAMP, which attained maximal values after a 2- to 3-min incubation, then rapidly decreased to the initial value and did not change over the next three hours of incubation. The possible role of cAMP in the induction of alternative oxidase in yeast cells is discussed.
authors.affiliation: Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, pr. Nauki 5, Pushchino, Moscow Oblast, 142290 Russia. medentsev@ibpm.serpukhov.su
authors.forename: A G
authors.initials: AG
authors.lastname: Medentsev
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Arinbasarova
authors.forename: V K
authors.initials: VK
authors.lastname: Akimenko
mesh_terms: D000968:Antimycin A / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D004790:Enzyme Induction; D000431:Ethanol / Q000494:pharmacology; D024101:Mitochondrial Proteins; D010088:Oxidoreductases / Q000096:biosynthesis*; D010940:Plant Proteins; D004718:Saccharomycetales / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D000099188:Alternative Oxidase
chemical_list: D000968:Antimycin A; D003486:Cyanides; D000242:Cyclic AMP; D000431:Ethanol; D024101:Mitochondrial Proteins; D010088:Oxidoreductases; D010940:Plant Proteins; D000099188:Alternative Oxidase