title: Targets for molecular intervention in multistep pulmonary carcinogenesis.
abstract: Lung cancers are a leading cause of mortality worldwide, and most of these neoplasms are directly attributable to tobacco abuse. Recent studies have begun to elucidate molecular mechanisms of multistep aero-digestive tract carcinogenesis, revealing novel targets for intervention in lung cancers and their precursor lesions. This review summarizes the molecular biology of lung cancers in relation to the prognosis and treatment of patients with these neoplasms.
authors.affiliation: Thoracic Oncology Section, Surgery Branch, National Cancer Institute, National Institutes of Health, Building 10, Room 2B-07, 10 Center Drive, Bethesda, Maryland 20892-1502, USA. david_schrump@nih.gov
authors.forename: D S
authors.initials: DS
authors.lastname: Schrump
authors.forename: D M
authors.initials: DM
authors.lastname: Nguyen
mesh_terms: D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic; D004260:DNA Repair / Q000502:physiology; D066246:ErbB Receptors / Q000378:metabolism; D016193:G1 Phase / Q000502:physiology; D016147:Genes, Tumor Suppressor / Q000502:physiology; D016158:Genes, p53 / Q000235:genetics; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics* / Q000503:physiopathology / Q000628:therapy; D010766:Phosphorylation; D010982:Platelet-Derived Growth Factor / Q000378:metabolism; D011519:Proto-Oncogenes / Q000502:physiology; D016160:Retinoblastoma Protein / Q000235:genetics
chemical_list: D010982:Platelet-Derived Growth Factor; D016160:Retinoblastoma Protein; D066246:ErbB Receptors