Protective effects of fructose-1,6-diphosphate against cerebral injury induced by subacute carbon monoxide intoxication in mice.
OBJECTIVE
To study the effects of fructose-1,6-diphosphate (FDP) on delayed cerebral injury in mice from subacute carbon monoxide (CO) exposure.


METHODS
Mice were exposed to CO (100 mL/kg i.p.) once a day, continouUsly for 7 d. After 7-d CO-exposure, mortality of mice, changes in learning ability and memory using passive avoidAnce test, the pathomorphologic observation of brain tissue slices, and changes in monoamine oxide (MAO)-B activities in cerebral tissue were studied. FDP was administrated 30 min before CO-exposure every time.


RESULTS
The preadministration of FDP markedly decreased the mortality of mice, almost reversed the impairment of learning and memory function, prevented the cells from delayed death in hippocampal neurons and blunted the rise in MAO-B activity after subacute CO poisoning of mice.


CONCLUSIONS
FDP pretreatment markedly prevented mice from delayed encephalopathy after CO poisoning.
Yang
J Q
JQ
Department of Biochemical Pharmacology, Chongqing University of Medical Sciences, Chongqing 400016, China.
Zhou
Q X
QX
D000818:Animals; D001362:Avoidance Learning; D001921:Brain / Q000378:metabolism; D001925:Brain Damage, Chronic / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002249:Carbon Monoxide Poisoning / Q000150:complications*; D005635:Fructosediphosphates / Q000494:pharmacology*; D006624:Hippocampus / Q000473:pathology; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D018696:Neuroprotective Agents / Q000494:pharmacology*
D005635:Fructosediphosphates; D018696:Neuroprotective Agents; D008995:Monoamine Oxidase; C029063:fructose-1,6-diphosphate