Early efferent innervation of the zebrafish lateral line.
We examined the efferent innervation of the lateral line in zebrafish larvae. Three efferent nuclei were previously reported for the posterior line, two in the hindbrain and one in the ventral hypothalamus. Here we show that the same three nuclei innervate the anterior line as well. The rhombencephalic neurons innervate either the anterior or the posterior line. The diencephalic neurons seem to innervate both lines as well as the ear. The diencephalic efferents are labeled by anti-tyrosine hydroxylase antibodies and probably use dopamine as a transmitter. They are among the very first catecholaminergic neurons to differentiate in the brain and extend branches into the lateral line system almost as soon as the latter forms. We discuss possible functions of the rhombencephalic and diencephalic efferents.
Bricaud
O
O
Laboratoire de Neurogénétique, INSERM E0012, Université Montpellier II, F-34095 Montpellier cedex 5, France.
Chaar
V
V
Dambly-Chaudière
C
C
Ghysen
A
A
D000818:Animals; D003911:Dextrans; D005452:Fluoresceins; D007031:Hypothalamus / Q000166:cytology* / Q000254:growth & development; D007202:Indicators and Reagents; D007814:Larva / Q000033:anatomy & histology; D008465:Mechanoreceptors / Q000166:cytology* / Q000254:growth & development; D009476:Neurons, Efferent / Q000201:enzymology; D012249:Rhombencephalon / Q000166:cytology* / Q000254:growth & development; D012679:Sense Organs / Q000254:growth & development / Q000294:innervation*; D013116:Spinal Cord / Q000166:cytology / Q000254:growth & development; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis; D015027:Zebrafish / Q000033:anatomy & histology*
D003911:Dextrans; D005452:Fluoresceins; D007202:Indicators and Reagents; C052526:fluorescein-dextran; D014446:Tyrosine 3-Monooxygenase