HIV viral load in Thai men and women with subtype E infections.
The assessment of potential "breakthrough infections" in HIV vaccine trials requires knowledge of viral load in unvaccinated persons. Therefore, HIV-1 RNA was quantitated in plasma from Thai adults with subtype E infections. RNA was detectable (> or =500 copies/ml) in 93% of 255 specimens, with a mean (standard deviation) value of 4.09 (0.88) log copies/ml. The concentration of RNA was directly related to the presence of AIDS-defining illnesses, inversely related to CD4 count, and independent of gender after adjustment for CD4 count.
Trichavaroj
R
R
Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.
de Souza
M S
MS
Buapunth
P
P
Markowitz
L
L
Sukwit
S
S
Nitayaphan
S
S
Brown
A E
AE
D016915:AIDS Vaccines / Q000276:immunology; D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000821:virology; D018791:CD4 Lymphocyte Count; D005260:Female; D015658:HIV Infections / Q000276:immunology / Q000821:virology*; D015497:HIV-1 / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics; D012727:Sex Characteristics; D013785:Thailand; D014611:Vaccination; D019562:Viral Load
D016915:AIDS Vaccines; D012367:RNA, Viral