title: Lucio's phenomenon: clinical and therapeutic aspects.
abstract: We report four cases of necrotizing reactions of the Lucio's phenomenon type, an entity rarely observed in Brazil despite the high prevalence of leprosy. Clinical, histopathological and therapeutic aspects are described and compared to those reported in the literature for cases classified as diffuse, non-nodular lepromatous leprosy with Lucio's phenomenon.
authors.affiliation: Division of Dermatology, Department of Internal Medicine, University Hospital, Faculty of Medicine of Ribeirao Preto, University of Sao Paulo, Av. Bandeirantes 3900, 14048-900 Ribeirao Preto, SP, Brazil. cacilda@usp.br
authors.forename: C S
authors.initials: CS
authors.lastname: Souza
authors.forename: A M
authors.initials: AM
authors.lastname: Roselino
authors.forename: F
authors.initials: F
authors.lastname: Figueiredo
authors.forename: N T
authors.initials: NT
authors.lastname: Foss
mesh_terms: D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001938:Brazil; D018450:Disease Progression; D004730:Endothelium, Vascular / Q000382:microbiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007917:Leprostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015440:Leprosy, Lepromatous / Q000188:drug therapy / Q000382:microbiology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009166:Mycobacterium leprae / Q000302:isolation & purification; D009336:Necrosis; D010431:Pentoxifylline / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011241:Prednisone / Q000008:administration & dosage / Q000627:therapeutic use*; D012883:Skin Ulcer / Q000382:microbiology / Q000473:pathology; D013927:Thrombosis / Q000473:pathology; D014657:Vasculitis / Q000473:pathology
chemical_list: D000893:Anti-Inflammatory Agents; D007917:Leprostatic Agents; D010975:Platelet Aggregation Inhibitors; D010431:Pentoxifylline; D011241:Prednisone