title: Effects of prolonged strenuous exercise on plasma levels of atrial natriuretic peptide and brain natriuretic peptide in healthy men.
abstract: BACKGROUND
  Now that marathon racing is growing in popularity, many thousands of enthusiastic athletes are participating in various ultramarathons all over the world each year. However, it remains controversial whether such a sport contributes to the promotion of health. The occurrence of transient cardiac dysfunction and irreversible myocardial injury has been reported in association with such exercise in healthy individuals. Brain natriuretic peptide (BNP) is a cardiac hormone, as is atrial natriuretic peptide (ANP), and its measurement has been widely used for clinical evaluation of cardiac dysfunction. However, little is known about the response of plasma BNP to prolonged strenuous exercise. We hypothesized that confirmation of minimal cardiac dysfunction or myocardial injury may be made by measurements of plasma BNP.
  
  
  METHODS
  Levels of plasma ANP, BNP, catecholamines, blood lactate, and serum cardiac troponin T (cTnT) were determined before and after a 100-km ultramarathon in 10 healthy men to examine the effects of the exercise on levels of ANP and BNP and correlations between the natriuretic peptides and cTnT as a marker for myocardial damage.
  
  
  RESULTS
  Whereas all variables significantly increased after the race, increased levels of ANP and BNP were most strongly correlated with increases in cTnT levels. The cTnT level after the race was greater than the upper reference limit in 9 of 10 men.
  
  
  CONCLUSIONS
  Such exercise significantly increased ANP and BNP levels in healthy men, and the increases could be partially attributed to myocardial damage during the race.
authors.affiliation: Department of Cardiology, St Marianna University School of Medicine, Kanagawa, Japan. h2ooba@marianna-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Ohba
authors.forename: H
authors.initials: H
authors.lastname: Takada
authors.forename: H
authors.initials: H
authors.lastname: Musha
authors.forename: J
authors.initials: J
authors.lastname: Nagashima
authors.forename: N
authors.initials: N
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Awaya
authors.forename: K
authors.initials: K
authors.lastname: Omiya
authors.forename: M
authors.initials: M
authors.lastname: Murayama
mesh_terms: D000328:Adult; D009320:Atrial Natriuretic Factor / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004837:Epinephrine / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000097:blood; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood; D009206:Myocardium / Q000378:metabolism; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D009638:Norepinephrine / Q000097:blood; D012016:Reference Values; D012189:Retrospective Studies; D012307:Risk Factors; D012420:Running / Q000502:physiology*; D020107:Troponin T / Q000097:blood
chemical_list: D015415:Biomarkers; D006454:Hemoglobins; D020107:Troponin T; D020097:Natriuretic Peptide, Brain; D019344:Lactic Acid; D009320:Atrial Natriuretic Factor; D009638:Norepinephrine; D004837:Epinephrine