Androgen-producing, atypically proliferating endometrioid tumor arising in endometriosis.
A case of androgen-secreting borderline endometrioid tumor arising in endometriosis of the rectovaginal septum is presented. It occurred 10 years after total abdominal hysterectomy and bilateral salpingo-oophorectomy for extensive endometriosis of the fallopian tubes and ovaries, adenomyosis, and leiomyomas of the uterus. We believe 7 years of unopposed continuous oral estrogen replacement therapy contributed to the malignant transformation of the endometriosis.
Powell
J L
JL
Department of Obstetrics and Gynecology, New Hanover Regional Medical Center, Wilmington, NC, USA.
Connor
G P
GP
Henderson
G S
GS
D015746:Abdominal Pain / Q000209:etiology; D000728:Androgens / Q000378:metabolism*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018269:Carcinoma, Endometrioid / Q000150:complications* / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003131:Combined Modality Therapy; D004414:Dyspareunia / Q000209:etiology; D004715:Endometriosis / Q000150:complications* / Q000601:surgery; D015914:Estrogen Replacement Therapy / Q000009:adverse effects / Q000379:methods; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D008940:Mitotic Index; D010052:Ovariectomy; D012004:Rectal Neoplasms / Q000150:complications* / Q000473:pathology*; D012086:Reoperation; D014057:Tomography, X-Ray Computed; D014625:Vaginal Neoplasms / Q000150:complications* / Q000473:pathology*
D000728:Androgens