title: Neuralized is essential for a subset of Notch pathway-dependent cell fate decisions during Drosophila eye development.
abstract: Neuralized (neur) is a neurogenic mutant of Drosophila in which many signaling events mediated by the Notch (N) receptor are disrupted. Here, we analyze the role of neur during eye development. Neur is required in a cell-autonomous fashion to restrict R8 and other photoreceptor fates and is involved in lateral inhibition of interommatidial bristles but is not required for induction of the cone cell fate. The latter contrasts with the absolute requirement for Suppressor of Hairless and the Enhancer of split-Complex for cone cell induction. Using gain-of-function experiments, we further demonstrate that ectopic wild-type and truncated Neur proteins can interfere with multiple N-controlled aspects of eye development, including both neur-dependent and neur-independent processes.
authors.affiliation: Howard Hughes Medical Institute, University of California, Department of Molecular and Cell Biology, 539 Life Sciences Addition, Berkeley, CA 94720-3200, USA. lai@fruitfly.bdgp.berkeley.edu
authors.forename: E C
authors.initials: EC
authors.lastname: Lai
authors.forename: G M
authors.initials: GM
authors.lastname: Rubin
mesh_terms: D000818:Animals; D019070:Cell Lineage / Q000502:physiology*; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins; D005123:Eye / Q000166:cytology / Q000196:embryology*; D008025:Ligases; D008565:Membrane Proteins / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000502:physiology*; D051880:Receptors, Notch; D044767:Ubiquitin-Protein Ligases
chemical_list: D029721:Drosophila Proteins; D008565:Membrane Proteins; C497759:N protein, Drosophila; D009419:Nerve Tissue Proteins; D051880:Receptors, Notch; D044767:Ubiquitin-Protein Ligases; C071006:neur protein, Drosophila; D008025:Ligases