The mimicry of human glycolipids and glycosphingolipids by the lipooligosaccharides of pathogenic neisseria and haemophilus.
It has been known for many years that bacteria can induce autoimmune responses in humans resulting in serious disease. Recent work has shown that a number of bacteria that colonize human mucosal surfaces exclusively express antigens on their surfaces which are molecular mimics of glycosphingolipids found on human cells. These structures are important in the pathogenesis of Neisseria and Haemophilus species for both immune evasion and in the adherence and invasion of human cells. There is no evidence that colonization or infections by these bacterial species is associated with autoimmune disease.
Harvey
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HA
Department of Microbiology, The University of Iowa, College of Medicine, Iowa City, IA, USA
Swords
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WE
Apicella
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MA
D000818:Animals; D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology; D006017:Glycolipids / Q000737:chemistry / Q000276:immunology*; D006028:Glycosphingolipids / Q000737:chemistry / Q000276:immunology*; D006193:Haemophilus influenzae / Q000276:immunology; D006801:Humans; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology*; D018716:Molecular Mimicry / Q000276:immunology*; D009344:Neisseria gonorrhoeae / Q000276:immunology; D009345:Neisseria meningitidis / Q000276:immunology
D000942:Antigens, Bacterial; D006017:Glycolipids; D006028:Glycosphingolipids; D008070:Lipopolysaccharides; C023023:lipid-linked oligosaccharides