[Comparative study between different conjunctival tissue adhesives].
OBJECTIVE
To evaluate efficacy and clinical and histopathological tolerance of a new acrylic tissue adhesive (ADAL-2) compared to sutures (Vicryl) and other available tissue adhesives (Tisuacryl) for their use in conjunctival surgery.


METHODS
This was an experimental study performed in New Zealand albino rabbits with conjunctival dissection and closure by ADAL-2. Groups treated with Vicryl and Tisuacryl were compared regarding efficacy, clinical, and histological tolerance at 7, 28 and 42 days.


RESULTS
Efficacy was similar in the three methods of conjunctival repositioning evaluated. Tolerance to ADAL-2 was similar to that of Vicryl suture and tolerance to ADAL-2 was superior to that to Tisuacryl. Histopathological results with ADAL-2 and Tisuacryl are similar.


CONCLUSIONS
ADAL-2 tissue adhesive is an efficient and very well tolerated alternative for conjunctival closure in ophthalmic surgery.
Gómez González
J J
JJ
Departamento de Patología y Cirugía, División de Oftalmología, Universidad Miguel Hernández, Alicante, España.
Mulet Homs
M E
ME
Alió y Sanz
J L
JL
Mahiques Bujanda
M M
MM
Molina Alfonso
Y
Y
Martín Martínez
J M
JM
D000179:Acrylates / Q000627:therapeutic use* / Q000633:toxicity; D000818:Animals; D019072:Antibiotic Prophylaxis; D003228:Conjunctiva / Q000473:pathology / Q000601:surgery*; D003231:Conjunctivitis / Q000139:chemically induced* / Q000473:pathology; D004353:Drug Evaluation, Preclinical; D005549:Foreign-Body Reaction / Q000209:etiology; D006099:Granuloma / Q000139:chemically induced; D008422:Materials Testing; D011098:Polyglactin 910 / Q000633:toxicity; D011183:Postoperative Complications / Q000139:chemically induced* / Q000473:pathology; D011817:Rabbits; D013537:Sutures; D014014:Tissue Adhesives / Q000627:therapeutic use* / Q000633:toxicity; D016896:Treatment Outcome
D000179:Acrylates; D014014:Tissue Adhesives; D011098:Polyglactin 910