The effects of allicin and enalapril in fructose-induced hyperinsulinemic hyperlipidemic hypertensive rats.
The effects of a synthetic preparation of an active constituent of garlic, allicin, were studied on blood pressure (BP), triglycerides, and insulin levels in Sprague-Dawley rats in which high fructose feeding elicited hyperinsulinemia, hypertension, and hypertriglyceridemia. Results were compared with those of the antihypertensive drug enalapril. Three groups of male Sprague-Dawley rats were fed a fructose-enriched diet for 5 weeks. During the last 2 weeks 10 animals received only fructose, 10 received allicin, and 10 received enalapril. Blood pressure, insulin level, and triglyceride levels were measured at the beginning of the experiment and after 3 and 5 weeks on the fructose diet, fructose/allicin diet, or fructose/enalapril diet. Allicin lowered BP from the maximal level (after 3 weeks of fructose) of 153.4 +/- 8 mm Hg to 139.7 +/- 12 mm Hg after 2 weeks on allicin; insulin from 11.7 +/- 3.7 ng/mL on fructose diet to 6.92 +/- 3.3 ng/mL on allicin; and triglycerides from 132.8 +/- 18 mg/dL on fructose to 59.6 +/- 27 mg/dL on allicin. The similar effect of allicin and enalapril on BP, insulin, and triglycerides reinforces the trend toward combining the nonpharmacologic approach with drug therapy.
Elkayam
A
A
Chorley Hypertension Research Institute, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Mirelman
D
D
Peleg
E
E
Wilchek
M
M
Miron
T
T
Rabinkov
A
A
Sadetzki
S
S
Rosenthal
T
T
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004220:Disulfides; D004656:Enalapril / Q000494:pharmacology*; D005632:Fructose; D006946:Hyperinsulinism / Q000097:blood* / Q000139:chemically induced; D006949:Hyperlipidemias / Q000097:blood* / Q000139:chemically induced; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013441:Sulfinic Acids / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D000959:Antihypertensive Agents; D004220:Disulfides; D000960:Hypolipidemic Agents; D007328:Insulin; D013441:Sulfinic Acids; D014280:Triglycerides; D005632:Fructose; C006452:allicin; D004656:Enalapril