title: Bupropion overdose in an adolescent.
abstract: Bupropion is a relatively new monocyclic antidepressant whose mechanism of action remains unknown. In addition to its use as an antidepressant, it has also been suggested to be effective in children with attention deficit hyperactive disorder and more recently as an aid in the cessation of cigarette smoking. The latter indication has resulted in an increase in its use and therefore an increased availability in households. To date, reports of overdoses in pediatric patients are limited. We report a 14-year-old boy who ingested 1.5 to 3 g of bupropion in a suicide attempt. Previous reports of bupropion ingestions and its management are discussed.
authors.affiliation: Department of Child Health, The University of Missouri, Columbia 65212, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ayers
authors.forename: J D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000293:Adolescent; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D016642:Bupropion / Q000506:poisoning* / Q000627:therapeutic use; D018765:Dopamine Uptake Inhibitors / Q000506:poisoning* / Q000627:therapeutic use; D062787:Drug Overdose / Q000628:therapy; D006801:Humans; D008297:Male; D012640:Seizures / Q000139:chemically induced*; D013406:Suicide, Attempted
chemical_list: D018765:Dopamine Uptake Inhibitors; D016642:Bupropion