title: Structure and neurotrophic activity of seco-prezizaane-type sesquiterpenes from Illicium merrillianum.
abstract: An extract of the pericarps of Illicium merrillianum has yielded four new sesquiterpenes: 3 alpha-hydroxycycloparvifloralone (1), 1,2-dehydrocycloparvifloralone (2), (11) 7,14-ortholactone-3 alpha-hydroxyfloridanolide (3), and 11-O-debenzoyltashironin (4) along with cycloparvifloralone (5), merrillianone (6), and tashironin (7). The structures of 1--4 were determined on the basis of spectroscopic analyses. 11-O-Debenzoyltashironin (4) showed neurotrophic activity in primary culture of rat cortical neurons at 0.1--10 microM. However, cycloparvifloralone-type sesquiterpenes (1, 2, 5, and 6) and tashironin (7) had no neurotrophic activity at these concentrations.
authors.affiliation: Institute of Pharmacognosy, Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan.
authors.forename: J M
authors.initials: JM
authors.lastname: Huang
authors.forename: R
authors.initials: R
authors.lastname: Yokoyama
authors.forename: C S
authors.initials: CS
authors.lastname: Yang
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuyama
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012717:Sesquiterpenes / Q000737:chemistry* / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D012717:Sesquiterpenes