Effects of Tween-80 on the biodistribution of several lipophilic technetium-99m complexes.
The effects of Tween-80 on the biodistributions in mice of (99m)Tc-TBI, (99m)Tc-MIBI, (99m)TcN-TBI and (99m)TcN-MIBI were reported. The studies resulted that liver and blood uptakes of Tween-80 added (TA) complexes significantly lower than that of corresponding non-Tween-80 added (NTA) complexes. And the clearance rate from blood of TA complexes faster than that of NTA complexes. The optimal concentration of Tween-80 was about 1%. It can decrease the lipophilicity of (99m)Tc-complexes and improve the biological properties of the lipophilic (99m)Tc-complexes for myocardial imaging. It's worthy for further studies.
Zhang
X Z
XZ
Department of Chemistry, Beijing Normal University, 100875, Beijing, People's Republic of China. zhang-xzh@263.net
Wang
X B
XB
Tang
Z G
ZG
Zhang
J B
JB
D000818:Animals; D004347:Drug Interactions; D005079:Excipients / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D011136:Polysorbates / Q000494:pharmacology*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D017556:Technetium Compounds / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D014018:Tissue Distribution / Q000187:drug effects
D005079:Excipients; D011136:Polysorbates; D019275:Radiopharmaceuticals; D017556:Technetium Compounds