title: Senile plaques in an aged western lowland gorilla.
abstract: Senile plaques (SPs) were found in the cerebral cortex of a 44-year-old Western lowland gorilla (Gorilla gorilla gorilla). All the SPs were obtained as dense assemblies consisting of fibrous materials by silver impregnation, but were not detected by Congo red. More SPs were detected by immunostaining for amyloid beta protein (A beta) and a half of A beta-positive-SPs were also immunoreactive for apolipoprotein E. Moreover, all SPs were immunoreactive for A beta 42 and A beta 43, but not for A beta 40. SPs also did not contain A beta precursor protein-positive structures. These findings suggested that SPs in this case were diffuse plaques. To our knowledge, this is the first report of SPs in the gorilla.
authors.affiliation: Department of Biomedical Science, Graduate School of Agricultural and Life Sciences, University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-8657, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Kimura
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Goto
authors.forename: E
authors.initials: E
authors.lastname: Narushima
authors.forename: I
authors.initials: I
authors.lastname: Hara
authors.forename: S
authors.initials: S
authors.lastname: Shichiri
authors.forename: K
authors.initials: K
authors.lastname: Saitou
authors.forename: M
authors.initials: M
authors.lastname: Nose
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Kawamura
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshikawa
mesh_terms: D000375:Aging; D016229:Amyloid beta-Peptides / Q000032:analysis; D000818:Animals; D001057:Apolipoproteins E / Q000032:analysis; D002540:Cerebral Cortex / Q000648:ultrastructure*; D006071:Gorilla gorilla / Q000033:anatomy & histology*; D007150:Immunohistochemistry; D008297:Male; D058225:Plaque, Amyloid / Q000737:chemistry / Q000648:ultrastructure*; D016622:Silver Staining
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E