title: Combined hepatocellular and cholangiocellular carcinoma in a dog.
abstract: A transitional type of combined hepatocellular and cholangiocellular carcinoma developed in a 12-year-old male Yorkshire terrier dog. The tumor was histologically composed of both hepatocellular carcinoma and cholangiocellular carcinoma components, and both elements were closely intermingled. Intraluminal mucin accumulation in cytokeratin-positive tubular/glandular structures was observed within the cholangiocellular carcinoma components and this feature was useful histological marker for a differential diagnosis between combined hepatocellular and cholangiocellular carcinoma and a pseudoglandular type of hepatocellular carcinoma. This primary hepatic tumor is extremely rare in dogs.
authors.affiliation: Department of Veterinary Pathology, Azabu University, Sagamihara, Kanagawa, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Shiga
authors.forename: K
authors.initials: K
authors.lastname: Shirota
authors.forename: M
authors.initials: M
authors.lastname: Enomoto
mesh_terms: D000818:Animals; D001650:Bile Duct Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D001653:Bile Ducts, Intrahepatic / Q000473:pathology* / Q000601:surgery / Q000648:ultrastructure; D006528:Carcinoma, Hepatocellular / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D018281:Cholangiocarcinoma / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary