[Expression of integrin beta 3 and intracellular adhesion molecule in endometrium and endometriotic tissue].
OBJECTIVE
To study the relationship between integrin beta 3, intracellular adhesion molecule (ICAM) and endometriosis.


METHODS
The expression of integrin beta 3 and ICAM protein were determined in 3 batches by immunoblotting method in 15 endometrium and 15 endometriotic tissues of patients with endometriosis and 30 endometrium from non-endometriosis subjects during the same menstrual phase. The results were scanned and semi-quantified, and then analysed by F test and t test.


RESULTS
The results from 3 measurements showed the same trend. Endometrium from patients with endometriosis expressed significantly fewer integrin beta 3 and ICAM protein than those without endometriosis. On the other hand, the expression of integrin beta 3 in endometriotic tissue was significantly lower while the ICAM expression was significantly higher than those in controls.


CONCLUSIONS
In patients with endometriosis, integrin beta 3 and ICAM expression changed significantly from eutopic to ectopic endometrium which may be related to the development of endometriosis and infertility.
Wu
J
J
Obstetrics and Gynecology Hospital of Shanghai Medical University, Shanghai 200011.
Zhang
J
J
Liu
Y
Y
D000328:Adult; D015703:Antigens, CD / Q000096:biosynthesis*; D004715:Endometriosis / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D039661:Integrin beta3; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis*; D008875:Middle Aged; D010980:Platelet Membrane Glycoproteins / Q000096:biosynthesis*; D014591:Uterine Diseases / Q000378:metabolism*
D015703:Antigens, CD; D039661:Integrin beta3; D010980:Platelet Membrane Glycoproteins; D018799:Intercellular Adhesion Molecule-1