title: Immunohistochemical distribution of DSIP immunoreactivity in the human hypothalamus during the first postnatal year. A preliminary report.
abstract: The distribution of DSIP-IR cell bodies and fibers was investigated in the normal human hypothalamus during the first postnatal year using the indirect immunofluorescence technique. The analysis of the immunohistochemical patterns obtained in the seven cases analyzed showed regional differences in the localization of cell bodies and fibers. Immunoreactive perikarya were relatively few, and were mostly scattered throughout the anterior and the mediobasal hypothalamus. DSIP-IR fibers and terminal-like structures were observed throughout the rostro-caudal extent of the hypothalamic region. In the present study, we noticed qualitative changes in the density of DSIP immunoreactivity in several hypothalamic structures such as the preoptic area and the median eminence with respect to age. These postnatal differences observed for DSIP could be related to neuronal maturation processes occurring at this period in the central nervous system as well as other physiological processes controlling the evolution of DSIP concentrations. These data are compatible with the proposed role of the neuropeptide in the regulation of many postnatal physiological functions.
authors.affiliation: Unité Génie Biologique, Faculté des Sciences et Techniques de Beni-Mellal, Morocco. mnaji-mi1@fstbm.ac.ma
authors.forename: M
authors.initials: M
authors.lastname: Najimi
authors.forename: M
authors.initials: M
authors.lastname: Bennis
authors.forename: E
authors.initials: E
authors.lastname: Moyse
authors.forename: N
authors.initials: N
authors.lastname: Kopp
authors.forename: F
authors.initials: F
authors.lastname: Chigr
mesh_terms: D000375:Aging; D002423:Cause of Death; D003701:Delta Sleep-Inducing Peptide / Q000032:analysis / Q000378:metabolism*; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000254:growth & development* / Q000473:pathology; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008473:Median Eminence / Q000254:growth & development / Q000473:pathology; D009412:Nerve Fibers / Q000473:pathology / Q000502:physiology; D009474:Neurons / Q000473:pathology / Q000502:physiology*; D011301:Preoptic Area / Q000254:growth & development / Q000473:pathology
chemical_list: D003701:Delta Sleep-Inducing Peptide