Excitation-contraction uncoupling: major role in contraction-induced muscle injury.
The mechanisms that account for the strength loss after contraction-induced muscle injury remain controversial. We present data showing that (1) most of   the early strength loss results from a failure of excitation-contraction coupling and (2) a slow loss of contractile protein in the days after injury prolongs the recovery time.
Warren
G L
GL
Department of Physical Therapy, Georgia State University, Atlanta, Georgia, USA. phtglw@langate.gsu.edu
Ingalls
C P
CP
Lowe
D A
DA
Armstrong
R B
RB
D000818:Animals; D015444:Exercise / Q000502:physiology; D006801:Humans; D009119:Muscle Contraction / Q000502:physiology*; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D009124:Muscle Proteins / Q000502:physiology; D018482:Muscle, Skeletal / Q000293:injuries*; D010805:Physical Conditioning, Animal / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000502:physiology; D014947:Wounds and Injuries / Q000503:physiopathology
D009124:Muscle Proteins