title: Comparison of results of thoracic radiography, cytologic evaluation of bronchoalveolar lavage fluid, and histologic evaluation of lung specimens in dogs with respiratory tract disease: 16 cases (1996-2000).
abstract: OBJECTIVE
  To compare results of thoracic radiography, cytologic evaluation of bronchoalveolar lavage (BAL) fluid, and histologic evaluation of biopsy and necropsy specimens in dogs with respiratory tract disease and to determine whether histologic evaluation provides important diagnostic information not attainable by the other methods.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  16 dogs.
  
  
  METHODS
  BAL fluid was classified as normal, neutrophilic, eosinophilic, mononuclear, mixed, neoplastic, or nondiagnostic. Radiographic abnormalities were classified as interstitial, bronchial, bronchointerstitial, or alveolar. Histologic lesions were classified as inflammatory, fibrotic, or neoplastic, and the predominant site of histologic lesions was classified as the alveoli, interstitium, or airway.
  
  
  RESULTS
  The predominant radiographic location of lesions correlated with the histologic location in 8 dogs. Of 11 dogs with histologic evidence of inflammatory disease, 8 had inflammatory BAL fluid. Of the 2 dogs with histologic evidence of neoplasia, 1 had BAL fluid suggestive of neoplasia, and the other had BAL fluid consistent with septic purulent inflammation. Two dogs without any histologic abnormalities had mononuclear or nondiagnostic BAL fluid. Two dogs with histologic evidence of fibrosis had mononuclear or mixed inflammatory BAL fluid.
  
  
  CONCLUSIONS
  Results suggest that although thoracic radiography, cytologic evaluation of BAL fluid, and histologic evaluation of lung specimens are complementary, each method has limitations in regard to how well results reflect the underlying disease process in dogs with respiratory tract disease. Lung biopsy should be considered in cases where results of radiography and cytology are nondiagnostic.
authors.affiliation: Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616-8734, USA.
authors.forename: C R
authors.initials: CR
authors.lastname: Norris
authors.forename: S M
authors.initials: SM
authors.lastname: Griffey
authors.forename: V F
authors.initials: VF
authors.lastname: Samii
authors.forename: M M
authors.initials: MM
authors.lastname: Christopher
authors.forename: M S
authors.initials: MS
authors.lastname: Mellema
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D001999:Bronchoscopy / Q000662:veterinary; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D005260:Female; D008168:Lung / Q000473:pathology*; D008297:Male; D013902:Radiography, Thoracic / Q000662:veterinary*; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D012189:Retrospective Studies