title: Neonatal thrombocytosis resulting from the maternal use of non-narcotic antischizophrenic drugs during pregnancy.
abstract: Neonatal thrombocytosis can result from maternal narcotic drug abuse. The case of a male infant is reported who was born to a woman with schizophrenia treated with non-narcotic psychotropic drugs during pregnancy; he developed severe prolonged thrombocytosis. The platelet count reached 1310 x 10(9)/l on day 15. This thrombocytosis persisted for three months. The patient was treated with dipyridamole. A bone marrow aspirate showed normal myeloid and erythroid precursors with an increased number of megakaryocytes. Plasma concentrations of interleukin 6 and thrombopoietin were suppressed. No obvious complications from the thrombocytosis occurred, and the platelet count fell to within the upper limit of normal after 3 months of age. This case indicates that thrombocytosis may occur in infants born to mothers treated with non-narcotic psychopharmaceutical drugs during pregnancy. The thrombocytosis in this case may have been induced by factors other than interleukin 6 or thrombopoietin.
authors.affiliation: Department of Paediatrics, Gunma University School of Medicine, Maebashi, Gunma, Japan. yanako@showa.gunma-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Nako
authors.forename: A
authors.initials: A
authors.lastname: Tachibana
authors.forename: T
authors.initials: T
authors.lastname: Fujiu
authors.forename: T
authors.initials: T
authors.lastname: Tomomasa
authors.forename: A
authors.initials: A
authors.lastname: Morikawa
mesh_terms: D004176:Dipyridamole / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000097:blood; D008297:Male; D009357:Neonatal Abstinence Syndrome / Q000097:blood / Q000188:drug therapy / Q000209:etiology*; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011619:Psychotropic Drugs / Q000009:adverse effects*; D012559:Schizophrenia / Q000188:drug therapy; D013922:Thrombocytosis / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D013926:Thrombopoietin / Q000097:blood
chemical_list: D015850:Interleukin-6; D010726:Phosphodiesterase Inhibitors; D011619:Psychotropic Drugs; D004176:Dipyridamole; D013926:Thrombopoietin