[The relation between placental pathologic changes and serum nitric oxide levels of maternal and umbilical blood in intrauterine growth retardation].
OBJECTIVE
To study the relation between placental pathologic changes and levels of maternal and umbilical serum nitric oxide (NO) in intrauterine growth retardation (IUGR).


METHODS
38 patients with IUGR (IUGR group) and 30 healthy pregnant women in their late trimester (control group) were studied from Nov. 1997 to Oct. 1998. The placenta and the appendages of fetus were studied after delivery. The concentration of serum NO were determined with cortas' method.


RESULTS
Placental pathological changes were found in 26 cases of IUGR group (68.42%), and the main pathological changes were growth retardation of villi and villositis. In the control group, 5 out of 30 cases had placental pathological findings (16.67%). There was statistically significant difference between the 2 groups (P < 0.01). In IUGR group, the maternal and umbilical NO concentration in the 26 cases with placental pathological changes decreased significantly when compared with that in 12 cases without obvious pathological findings of placenta (P < 0.05, P < 0.05); NO levels of umbilical cord were higher than that of maternal serum in both groups(P < 0.01, P < 0.05); There was correlation about serum NO concentration between mother and her fetus in both groups (r = 0.5475, r = 0.8506); but umbilical serum NO level was not related to the weight of the newborn (r = 0.2838).


CONCLUSIONS
The obvious placental pathologic changes occurred in patient with IUGR caused noticeably lower NO levels in maternal and umbilical serum.
Ying
X
X
Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011.
Chen
Y
Y
Ding
J
J
D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D005317:Fetal Growth Retardation / Q000097:blood / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D009569:Nitric Oxide / Q000097:blood*; D010920:Placenta / Q000473:pathology*; D011247:Pregnancy
D009569:Nitric Oxide