title: Biologically active substituted benzodiazepines and their effect on cardiovascular and central nervous system.
abstract: Some substituted 1,5-benzodiazepine derivatives (including a spirocyclopentane moiety) were synthesized (Table I) and evaluated for their hypotensive and CNS activities respectively. The compounds which showed promising cardiovascular activity also exhibited marked anti-depressant action (Table II,III,IV). All the compounds showed higher ALD50 value.
authors.affiliation: Department of Pharmacology and Therapeutics, K.G. Medical College, Lucknow, India.
authors.forename: S
authors.initials: S
authors.lastname: Shukla
authors.forename: U
authors.initials: U
authors.lastname: Misra
authors.forename: M
authors.initials: M
authors.lastname: Bhalla
authors.forename: D
authors.initials: D
authors.lastname: Mukerjee
authors.forename: A K
authors.initials: AK
authors.lastname: Saxena
authors.forename: J N
authors.initials: JN
authors.lastname: Sinha
authors.forename: K
authors.initials: K
authors.lastname: Shanker
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D008297:Male; D051379:Mice
chemical_list: D001569:Benzodiazepines