Role of inflammation in chemical-induced hepatotoxicity.
The liver, which is the major organ responsible for the metabolism of drugs and toxic chemicals, is also the primary target organ for many toxic chemicals. Increasing evidence has indicated that inflammatory processes are intimately involved in chemical-induced hepatotoxic processes, and like other inflammatory diseases, such as autoimmunity, are responsible for producing mediators that can effect liver damage or repair. This review will summarize our current understanding of how inflammatory processes influence hepatic pathology and repair following exposure to established hepatotoxic chemicals including carbon tetrachloride, an industrial chemical, and acetaminophen, a widely used analgesic.
Luster
M I
MI
Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Road, Mailstop 3014, Morgantown, WV 26505, USA. mluster@cdc.gov
Simeonova
P P
PP
Gallucci
R M
RM
Bruccoleri
A
A
Blazka
M E
ME
Yucesoy
B
B
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects*; D051379:Mice; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D018809:Proliferating Cell Nuclear Antigen; D018124:Receptors, Tumor Necrosis Factor; D014409:Tumor Necrosis Factor-alpha