Dendritic cells as regulators of the immune response to inhaled allergen: recent findings in animal models of asthma.
Antigen-presenting dendritic cells are essential for the recognition and presentation of allergens to the cells of the immune system. Airway dendritic cells capture allergen in the mucosa and present it to naive T cells after migration into the draining lymph nodes. In this review article, we discuss the most recent findings from animal models of asthma, which highlight an essential role for these cells in the induction and maintenance of eosinophilic airway inflammation. This increasing knowledge might lead to the identification of new targets for the prevention and therapy of asthma.
Lambrecht
B N
BN
Department of Pulmonary and Critical Care Medicine, Erasmus Medical Center Rotterdam, Rotterdam, The Netherlands. lambrecht@lond.azr.nl
Hoogsteden
H C
HC
Pauwels
R A
RA
D000280:Administration, Inhalation; D000485:Allergens / Q000008:administration & dosage / Q000276:immunology; D000818:Animals; D017951:Antigen Presentation; D001249:Asthma / Q000276:immunology* / Q000473:pathology; D003713:Dendritic Cells / Q000276:immunology*; D004195:Disease Models, Animal; D006801:Humans; D008168:Lung / Q000276:immunology / Q000473:pathology; D051379:Mice; D018448:Models, Immunological; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology; D011657:Pulmonary Eosinophilia / Q000276:immunology; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology
D000485:Allergens; D010047:Ovalbumin