Man-made respirable-sized organic fibers: what do we know about their toxicological profiles?
Man-made organic fibers (MMOFs) have been manufactured for over 50 years. Until recently, there have been few concerns raised regarding the safety of organic fiber dusts. This is due, in large part, to the perception that the dimensions of most, if not all, of these products were too large to be inhaled into the distal lungs of workers, i.e., were considered to be nonrespirable. A brief review of some of the issues related to organic fiber toxicology is presented herein. Some of the organic fiber-types used in commerce are identified and some fundamental tenets of fiber toxicology are discussed. In addition, the European Union, in their recent consideration for banning chrysotile asbestos fibers, evaluated some organic fiber substitutes and compared them to the hazards of asbestos. A brief review of their conclusions is described below. Finally, the results of some recent studies assessing the mechanisms of biodegradability of para-aramid respirable-sized, fiber-shaped particulates (RFP) are presented. Para-aramid (p-aramid) RFP are the most extensively-studied respirable organic fiber-type and RFP is the new term which describes respirable-sized organic fibers (ECETOC, 1996) (1). The results of these studies provide clues regarding the mechanism(s) of p-aramid RFP shortening in the lungs of exposed animals, and may be relevant for humans.
Warheit
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DuPont Haskell Laboratory, Newark, Delaware 19714-0050, USA.
Reed
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KL
Webb
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TR
D000280:Administration, Inhalation; D000818:Animals; D017632:Asbestos, Serpentine / Q000493:pharmacokinetics / Q000633:toxicity; D001673:Biodegradation, Environmental; D002273:Carcinogens / Q000493:pharmacokinetics / Q000633:toxicity; D002482:Cellulose / Q000493:pharmacokinetics / Q000633:toxicity*; D004391:Dust; D006801:Humans; D008168:Lung / Q000378:metabolism* / Q000473:pathology*; D016273:Occupational Exposure; D010316:Particle Size; D011108:Polymers / Q000493:pharmacokinetics / Q000633:toxicity*; D011142:Polyvinyl Alcohol / Q000493:pharmacokinetics / Q000633:toxicity*
D017632:Asbestos, Serpentine; D002273:Carcinogens; D004391:Dust; C039578:Kevlar Aramid fibers; D011108:Polymers; D011142:Polyvinyl Alcohol; D002482:Cellulose