Role of nitric oxide and lipid peroxidation in mechanisms of febrile convulsions in Wistar rat pups.
Generation of nitric oxide and the content of lipid peroxidation products in the brain are increased in rat pups during febrile convulsions. NO-synthase inhibitor N-nitro-L-arginine in a dose of 250 mg/kg prevented hyperthermia-induced accumulation of nitric oxide, increased the latency febrile convulsions, and had no effect on the content of lipid peroxidation products.
Klyueva
Y A
YA
Department of Human and Animal Physiology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow. juliakl@mail.ru
Bashkatova
V G
VG
Vitskova
G Y
GY
Narkevich
V B
VB
Mikoyan
V D
VD
Vanin
A F
AF
Chepurnov
S A
SA
Chepurnova
N E
NE
D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000378:metabolism*; D004578:Electron Spin Resonance Spectroscopy; D004791:Enzyme Inhibitors / Q000494:pharmacology; D015227:Lipid Peroxidation; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D003294:Seizures, Febrile / Q000378:metabolism*; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D013997:Time Factors
D004791:Enzyme Inhibitors; D017392:Thiobarbituric Acid Reactive Substances; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase