title: A novel translocation t(2;9)(q14;p12) in AML-M2 with an uncommon phenotype: myeloperoxidase-positive and myeloid antigen-negative.
abstract: We report a case of acute myeloid leukemia (AML-M2) expressing myeloperoxidase (MPO) but no myeloid antigens. A few cases with this discordant phenotype have been reported and an association has been suggested between the lack of CD13 and CD33 in MPO positive AML and the presence of t(8;21). Cytogenetic and molecular analyses performed in our case showed 48,XY,+Y,+8,t(2;9)(q14;p12). We believe that combined approaches can contribute to detect particular AL cases like the present one, that confirms the heterogeneity of AML. However, further studies are needed to clarify the relationship between phenotypic aberrations and cytogenetic abnormalities.
authors.affiliation: Department of Hematology, University of Bari, Piazza Giulio Cesare n. 11, 70124, Bari, Italy. emadhba@cimedoc.uniba.it
authors.forename: G
authors.initials: G
authors.lastname: Specchia
authors.forename: A
authors.initials: A
authors.lastname: Mestice
authors.forename: T
authors.initials: T
authors.lastname: Clelia Storlazzi
authors.forename: L
authors.initials: L
authors.lastname: Anelli
authors.forename: A
authors.initials: A
authors.lastname: Pannunzio
authors.forename: M
authors.initials: M
authors.lastname: Grazia Roberti
authors.forename: M
authors.initials: M
authors.lastname: Rocchi
authors.forename: V
authors.initials: V
authors.lastname: Liso
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D018826:CD13 Antigens / Q000032:analysis; D002648:Child; D002889:Chromosomes, Human, Pair 2; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology / Q000235:genetics* / Q000276:immunology; D008875:Middle Aged; D009195:Peroxidase / Q000378:metabolism*; D063268:Sialic Acid Binding Ig-like Lectin 3; D014178:Translocation, Genetic
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; C571163:CD33 protein, human; D063268:Sialic Acid Binding Ig-like Lectin 3; D009195:Peroxidase; D018826:CD13 Antigens