Acute iliac vein thrombosis in pregnancy treated successfully by streptokinase lysis: a case report.
BACKGROUND
Postthrombotic syndrome is an important late complication after deep vein thrombosis in pregnancy. Thrombolytic agents are more efficient in preventing this condition but are rarely used in pregnant women.


METHODS
A 22-year-old woman at 29 weeks of gestation presented with acute iliac vein thrombosis. After application of a heparin bolus, systemic streptokinase lysis was performed. Low-dose heparin therapy was continued for the remainder of the, otherwise unremarkable, pregnancy. Spontaneous delivery of a healthy girl was without complications and thromboprophylaxis with low-molecular heparin was continued.


CONCLUSIONS
Thrombolysis in pregnancy is possible and may help to prevent severe long-term sequelae of thrombosis in young women. Bleeding is a major risk, which must be considered and therapy should only be administered under close observation.
Henrich
W
W
Department of Obstetrics and Gynecology, Charité Campus Virchow-Klinikum, Humboldt-University of Berlin, Germany. wolfgang.henrich@charite.de
Schmider
A
A
Henrich
M
M
Dudenhausen
J W
JW
D000328:Adult; D005260:Female; D005865:Gestational Age; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007084:Iliac Vein; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011256:Pregnancy Outcome; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D020246:Venous Thrombosis / Q000188:drug therapy*
D006493:Heparin; D013300:Streptokinase