Activity of amphotericin B in lipid emulsion in the initial treatment of canine leishmaniasis.
Amphotericin B was given to 19 dogs with leishmaniasis. The drug was diluted in an emulsion prepared by mixing 50 mg of amphotericin B desoxycholate with 40 ml of sterile water and 10 ml of soya bean oil solution. The dogs were infused over nearly one hour with 50 ml/kg of normal saline followed by 10 ml/kg of mannitol 20 per cent. The mixture was then loaded over 30 to 60 minutes using a syringe pump. The emulsion was given twice weekly, at an increasing dosage (from 1 to 2.5 mg/kg bodyweight), for a minimum of eight injections. All 17 dogs receiving a total dosage of more than 10 mg/kg were clinically cured by the end of the treatment, and 14 of these had a negative polymerase chain reaction test on bone marrow.
Lamothe
J
J
Clinique Veterinaire, Carros, France.
D000666:Amphotericin B / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004334:Drug Administration Schedule; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous / Q000662:veterinary; D018314:Leishmania infantum; D007896:Leishmaniasis / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D016896:Treatment Outcome; D015047:Zoonoses
D000981:Antiprotozoal Agents; D005217:Fat Emulsions, Intravenous; D000666:Amphotericin B