title: Value of tumor M2 (Tu M2-PK) in patients with renal carcinoma.
abstract: Pyruvate kinase is one of the glycolytic key enzymes. It exists in various isoforms which are expressed in different cell types. One of these isoforms, the type Tu M2-PK, is strongly overexpressed by tumor cells and released into body fluids. The concentration of Tu M2-PK in body fluids can be quantitatively determined by a commercially available enzyme-linked immunosorbent assay (ELISA)-kit. The Tu M2-PK concentration was measured in EDTA-plasma of 116 patients with renal carcinoma and 42 patients suffering from nephritis, by using this kit. The ranges of the Tu M2-PK-concentrations of the two groups did not overlap, indicating a highly significant discrimination of renal carcinoma and benign renal diseases. Furthermore, the Tu M2-PK concentration in EDTA-plasma correlated strongly with the Robson tumor stage of the 116 patients. The present results indicated that the Tu M2-PK might be the first tumor marker, which could be an excellent complementation of the diagnostic program for renal carcinoma.
authors.affiliation: Klinikum der Johann-Wolfgang Goethe-Universität Frankfurt, Zentrallabor-Zentrum der Inneren Medizin, Theodor-Stern-Kai 7, D-60590 Frankfurt/Main, Germany.
authors.forename: G M
authors.initials: GM
authors.lastname: Oremek
authors.forename: N
authors.initials: N
authors.lastname: Sapoutzis
authors.forename: W
authors.initials: W
authors.lastname: Kramer
authors.forename: R
authors.initials: R
authors.lastname: Bickeböller
authors.forename: D
authors.initials: D
authors.lastname: Jonas
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood*; D002292:Carcinoma, Renal Cell / Q000097:blood* / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis; D007680:Kidney Neoplasms / Q000097:blood* / Q000175:diagnosis; D011770:Pyruvate Kinase / Q000097:blood*
chemical_list: D014408:Biomarkers, Tumor; D011770:Pyruvate Kinase