title: [Familial occurrence of nephroblastoma].
abstract: Wilms' tumour can develop in ways: sporadic--non-hereditary or familial. Familial Wilms' tumour is not very seldom. It is a form of autosomal dominant segregation and probably low and variable penetration. Up to now it has not been observed in the presence of characteristic genetic changes. Taking into consideration the case of the patient with positive family interview we presented the way of diagnosing and treating the child. Moreover we presented the results of cytogenetic examination and molecular analyses (loss of heterozygosity of WT1 gene and loss of heterozygosity 16 q), which had not shown any changes. We also discussed the actual level of knowledge abut familial form of Wilms' tumour.
authors.affiliation: Klinika Chirurgii i Onkologii Dzieciecej Instytutu Pediatrii Akademii Medycznej w Łodzi.
authors.forename: G
authors.initials: G
authors.lastname: Skotnicka-Klonowicz
authors.forename: P
authors.initials: P
authors.lastname: Rieske
authors.forename: J
authors.initials: J
authors.lastname: Bartkowiak
authors.forename: M
authors.initials: M
authors.lastname: Debiec-Rychter
mesh_terms: D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000175:diagnosis / Q000235:genetics*; D025063:Chromosome Disorders; D002885:Chromosomes, Human, Pair 16; D006801:Humans; D008297:Male; D009396:Wilms Tumor / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy