title: [Histiocytic necrotizing lymphadenitis (Kikuchi-Fujimoto disease)].
abstract: BACKGROUND
  Histiocytic necrotizing lymphadenitis is a disease of unknown etiology, favourable course and outcome, mostly encountered in young women. It exhibits increased temperature and lymphadenopathy. The illness resolved spontaneously after a few months.
  
  
  METHODS
  In a 32-year-old patient the disease developed gradually, with pain in the right axilla, within enlarged lymph. Two weeks later, her temperature increased to 39 degrees C, accompanied by fever, shivering, malaise and loss of appetite. The ultrasonographic finding showed a conglomerate of hypoechogenic lymph nodes, with a few enlarged lymph glands. By immunohistochemical examination of a gland tissue sample the diagnosis was established Kikuchi-Fujimoto disease ("Histiocytica necrotizing lymphadenitis"--"Apoptotic lymphadenitis"). Corticosteroid therapy had been administered for one year, which resulted in both subjective improvement and regression of enlarged lymph nodes.
  
  
  CONCLUSIONS
  A connection between this disease and viruses has not been proved. Presence of intracellular tubuloreticular formations suggests autoimmune etiology of histiocytic necrotizing lymphadenitis. It is considered as hyperimmune reaction of the organism induced by a viral infection. Differential diagnosis should consider taxoplasmosis, tuberculosis, lymphadenitis and malignant lymphoma.
  
  
  CONCLUSIONS
  Although histiocytic necrotizing lymphadenitis is a rare disease, this case shows that it should be considered when lymphadenopathy, particularly cervical, occurs in young women, accompanied by increased temperature.
authors.affiliation: Klinika za infektivne bolesti, Klinicki centar, Novi Sad, Medicinski fakultet, Novi Sad, 21000 Novi Sad, Hajduk Veljkova. turkulov@eunet.yu
authors.forename: N
authors.initials: N
authors.lastname: Madle-Samardzija
authors.forename: V
authors.initials: V
authors.lastname: Turkulov
authors.forename: J
authors.initials: J
authors.lastname: Vukadinov
authors.forename: S
authors.initials: S
authors.lastname: Stajnic
authors.forename: G
authors.initials: G
authors.lastname: Canak
mesh_terms: D000328:Adult; D005260:Female; D020042:Histiocytic Necrotizing Lymphadenitis / Q000175:diagnosis / Q000628:therapy; D006801:Humans