title: [The effect of chronic alcohol use on heart rate variability].
abstract: A long lasting alcohol intake causes, amongst numerous systemic damages, also the autonomic nervous system (ANS) dysfunction, which causes the autonomic heart rate regulation disorders. The aim of the study was to evaluate the autonomic regulation of the circulation in chronic alcoholism. Seventeen alcoholics, 24-55 years of age (mean 43 +/- 5.2 years) were examined. They have been abstainers for 2-6 years. The cardiac ANS function was evaluated using the HRV measurement. The HRV was registered using V6 EKG lead. The recording was performed through the 15 min of resting conditions and 5 min of the deep breathing test. A group containing healthy volunteers, matched for age and gender, for the comparison of the HRV results was recruited. In the examined group, during the resting conditions, the significant RR period changes weren't observed (999.7 +/- 139.2 vs. 967 +/- 144.9; p > 0.05). The nonsignificant lower values of the spectral analysis parameters of HRV: LF (954.1 +/- 1162.6 vs. 1456.4 +/- 1327.1; p > 0.05) and HF (676.4 +/- 414.2 vs. 1557 +/- 1854.4; p > 0.05) and LF/HF ratio (1.5 +/- 1.14 vs. 1.38 +/- 1.28; p > 0.05) were also noticed. In response to the DB test, the mean value of the RR period wasn't significantly changed (921.4 +/- 152.3 vs. 930.6 +/- 137.8; p > 0.05). In DB test the significant decrease of LF (3465.8 +/- 2750.1 vs. 11558.6 +/- 7902.5; p < 0.001) and HF (406.1 +/- 366.8 vs. 1665 +/- 1757.1; p < 0.01) was observed. No significant change of LF/HF mean ratio (11.6 +/- 6.97 vs. 14.7 +/- 11.6; p > 0.05) was noticed. The results of our study indicate on the maintenance of the HRV disorders in chronic alcoholics, during the abstinence.
authors.affiliation: Katedra Patofizjologii Collegium Medicum UJ ul. Czysta 18, 31-121 Kraków. agatap@mp.pl
authors.forename: A
authors.initials: A
authors.lastname: Pitala
authors.forename: T
authors.initials: T
authors.lastname: Banach
authors.forename: K
authors.initials: K
authors.lastname: Szmigiel
authors.forename: A
authors.initials: A
authors.lastname: Krygowska-Wajs
authors.forename: W
authors.initials: W
authors.lastname: Kolasińska-Kloch
authors.forename: J
authors.initials: J
authors.lastname: Laskiewicz
authors.forename: P J
authors.initials: PJ
authors.lastname: Thor
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000150:complications*; D001145:Arrhythmias, Cardiac / Q000175:diagnosis / Q000209:etiology*; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged