[Modulatory action of alpha 2-adrenoceptor on calcitonin gene-related peptide release from rat mesenteric arterial bed].
The release of calcitonin gene-related peptide (CGRP) from peripheral terminals of sensory nerves was modulated via multiple mechanisms. In the present study, pharmacological agents were used to investigate the modulatory action of alpha 2-adrenoceptor on endotoxin-induced CGRP release from isolated perfused rat mesenteric arterial bed. The results showed that UK14304 (3 x 10(-6) mol/L), a potent alpha 2-adrenoceptor agonist, significantly inhibited both basal and endotoxin-induced CGRP release by 22%-42%, while specific antagonist of alpha 2-adrenoceptor yohimbine (10(-5) mol/L) blocked the effect of UK14304 completely. The data suggest that presynaptic alpha 2-adrenoceptor has an inhibitory effect on basal and endotoxin-induced CGRP release. Dysfunction of alpha 2-adrenoceptor in the late stage of endotoxic shock may be involved in the excess release of CGRP from the peripheral nerves.
Sun
W
W
Institute of Vascular Medicine, Third Hospital, Beijing Medical University, Beijing 100083.
Han
Q D
QD
Tang
Y M
YM
Wang
X
X
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D000068438:Brimonidine Tartrate; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D004731:Endotoxins; D066298:In Vitro Techniques; D008297:Male; D008638:Mesenteric Arteries / Q000378:metabolism*; D011810:Quinoxalines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology*; D015016:Yohimbine / Q000494:pharmacology
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D004731:Endotoxins; D011810:Quinoxalines; D018341:Receptors, Adrenergic, alpha-2; D015016:Yohimbine; D000068438:Brimonidine Tartrate; D015740:Calcitonin Gene-Related Peptide