Structure of cytochrome c oxidase: a comparison of the bacterial and mitochondrial enzymes.
It has been almost 5 years since the first structures of cytochrome c oxidase, from Paracoccus denitrificans and bovine heart mitochondria, were revealed. Since then many different proton pumping mechanisms have been proposed for the enzyme; however, no definitive conclusion has been achieved. In this article, we revisit the original structures of bacterial and mitochondrial oxidases and try to clarify similarities as well as differences between the two structures.
Abramson
J
J
Department of Biochemistry, Upssala Univeristy, Biomedical Center, Sweden.
Svensson-Ek
M
M
Byrne
B
B
Iwata
S
S
D000818:Animals; D002417:Cattle; D003576:Electron Transport Complex IV / Q000737:chemistry*; D008929:Mitochondria, Heart / Q000201:enzymology*; D010231:Paracoccus denitrificans / Q000201:enzymology*; D011487:Protein Conformation
D003576:Electron Transport Complex IV