Cell transplantation for the treatment of Parkinson's disease.
Cell transplantation is an experimental therapy for Parkinson's disease (PD) and other movement disorders. Several open-label research trials have shown clinically meaningful improvement in parkinsonian signs and symptoms after striatal transplantation of allogeneic fetal ventral mesencephalic (FVM) tissue. However, ethical concerns, variability in surgical techniques, and reports of unusual late complications in a few patients in a clinical trial have limited the use of allogeneic FVM tissue to a few research centers. Research into alternative cell sources such as porcine FVM and allogeneic retinal pigment epithelial cells has shown promising results in preclinical trials, and they are currently being tested in clinical trials. Novel strategies to improve cell survival and to avoid immune rejection of transplants show promising results in preclinical trials. This article focuses on these recent advances and compares the potential clinical utility of these emerging cell therapies for the treatment of advanced PD.
Subramanian
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Department of Neurology, Cleveland Clinic Foundation, OH 44195, USA.
D000818:Animals; D017690:Cell Transplantation; D016332:Fetal Tissue Transplantation; D006801:Humans; D008636:Mesencephalon / Q000196:embryology; D010300:Parkinson Disease / Q000601:surgery*; D010857:Pigment Epithelium of Eye / Q000166:cytology; D013552:Swine / Q000196:embryology; D014183:Transplantation, Heterologous