[A computer image processing system to analyze endothelial cell-platelet thrombus quantitatively].
A Computer Image Processing System for cone-plate rolling model which forms endothelial cell-platelet thrombus in vitro is presented in this paper. Some parameters such as endothelial cell shape parameters (area, perimeter, long axial length, short axial length, angle of orientation, and shape index), platelet adhesion coverage, platelet adhesion density, diffusivity and surface reactivity constant are measured during the reaction of endothelial cells and platelet under the fluid shear stress condition. The invitro thrombus model and the corresponding quantitative analysis system is useful in the studies on endothelial cells-platelets interaction and mechanism of thrombosis and atherosclerosis.
Zhang
H
H
Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027.
Zheng
X
X
D001792:Blood Platelets / Q000502:physiology*; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000166:cytology*; D007091:Image Processing, Computer-Assisted / Q000295:instrumentation*; D008962:Models, Theoretical; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D012985:Software Design; D013927:Thrombosis / Q000503:physiopathology*