title: Restitution of alpha-topography by piracetam in post-stroke aphasia.
abstract: OBJECTIVE
  Electroencephalographic and clinical effects of piracetam in post-stroke aphasia were evaluated in a prospective, randomized, double-blind, placebo-controlled trial.
  
  
  METHODS
  In 24 patients with mild to moderate aphasia after ischemic stroke, quantitative topographic EEG at rest was studied before and after a 6-week treatment period.
  
  
  RESULTS
  In the active treatment group, a significant shift in the alpha-rhythm from frontal to occipital regions was observed which may be due to a restitution of corticothalamic circuits involved in the generation of alpha-activity.
  
  
  CONCLUSIONS
  Neuropsychological scores improved significantly and markedly in various domains of speech during piracetam treatment, whereas improvements were less marked and restricted to a few categories in the placebo group.
authors.affiliation: Neurologische Universitätsklinik, Köln, Germany. b.szelies@pet.mpin-koeln.mpg.de
authors.forename: B
authors.initials: B
authors.lastname: Szelies
authors.forename: R
authors.initials: R
authors.lastname: Mielke
authors.forename: J
authors.initials: J
authors.lastname: Kessler
authors.forename: W D
authors.initials: WD
authors.lastname: Heiss
mesh_terms: D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001037:Aphasia / Q000188:drug therapy* / Q000209:etiology; D001931:Brain Mapping / Q000379:methods; D004311:Double-Blind Method; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018696:Neuroprotective Agents / Q000627:therapeutic use*; D009483:Neuropsychological Tests; D010889:Piracetam / Q000627:therapeutic use*; D011446:Prospective Studies; D020521:Stroke / Q000150:complications; D016896:Treatment Outcome
chemical_list: D018696:Neuroprotective Agents; D010889:Piracetam