Cerebral involvement in graft-versus-host disease after murine bone marrow transplantation.
Neurologic manifestation of graft-versus-host disease (GvHD) after allogeneic bone marrow transplantation (BMT) has until now been limited to rare neuromuscular syndromes. Investigating cerebral findings using a murine BMT model, the authors found parenchymal lymphocytic inflammation, microglia activation, and mild cerebral angiitis-like changes in allogeneic transplanted animals but not in syngeneic controls. These findings suggest that cerebral involvement during GvHD may be a new neurologic complication after BMT.
Padovan
C S
CS
Department of Neurology, Ludwig Maximilians University, Munich, Germany. padovan@brain.nefo.med.uni-muenchen.de
Gerbitz
A
A
Sostak
P
P
Holler
E
E
Ferrara
J L
JL
Bise
K
K
Straube
A
A
D000818:Animals; D016026:Bone Marrow Transplantation / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D006086:Graft vs Host Disease / Q000276:immunology*; D006087:Graft vs Host Reaction / Q000276:immunology*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D017628:Microglia / Q000276:immunology; D009836:Oligodendroglia / Q000276:immunology; D010586:Phagocytes / Q000276:immunology; D014184:Transplantation, Homologous
D017493:Leukocyte Common Antigens