title: Feline immunodeficiency virus cell entry.
abstract: The process of feline immunodeficiency virus (FIV) cell entry was examined using assays for virus replication intermediates. FIV subtype B was found to utilize the chemokine receptor CXCR4, but not CCR5, as a cellular receptor. Zidovudine blocked formation of late viral replication products most effectively, including circular DNA genome intermediates. Our findings extend the role of CXCR4 as a primary receptor for CD4-independent cell entry by FIV.
authors.affiliation: Department of Microbiology, University of Washington, Seattle, Washington 98195, USA.
authors.forename: S C
authors.initials: SC
authors.lastname: Frey
authors.forename: E A
authors.initials: EA
authors.lastname: Hoover
authors.forename: J I
authors.initials: JI
authors.lastname: Mullins
mesh_terms: D000818:Animals; D002460:Cell Line; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects / Q000502:physiology*; D019718:Receptors, CXCR4 / Q000502:physiology; D011991:Receptors, Virus / Q000502:physiology; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology
chemical_list: D019718:Receptors, CXCR4; D011991:Receptors, Virus; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine