title: A study of deleterious gene structure in plants using Markov chain Monte Carlo.
abstract: The characteristics of deleterious genes have been of great interest in both theory and practice in genetics. Because of the complex genetic mechanism of these deleterious genes, most current studies try to estimate the overall magnitude of mortality effects on a population, which is characterized classically by the number of lethal equivalents. This number is a combination of several parameters, each of which has a distinct biological effect on genetic mortality. In conservation and breeding programs, it is important to be able to distinguish among different combinations of these parameters that lead to the same number of lethal equivalents, such as a large number of mildly deleterious genes or a few lethal genes, The ability to distinguish such parameter combinations requires more than one generation of mating. We propose a model for survival data from a two-generation mating experiment on the plant species Brassica rapa, and we enable inference with Markov chain Monte Carlo. This computational strategy is effective because a vast amount of missing genotype information must be accounted for. In addition to the lethal equivalents, the two-generation data provide separate information on the average intensity of mortality and the average number of deleterious genes carried by an individual. In our Markov chain Monte Carlo algorithm, we use a vector proposal distribution to overcome inefficiency of a single-site Gibbs sampler. Information about environmental effects is obtained from an outcrossing experiment conducted in parallel with the two-generation mating experiments.
authors.affiliation: Division of Basic Sciences, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. jaekyun1@hto.usc.edu
authors.forename: J K
authors.initials: JK
authors.lastname: Lee
authors.forename: M
authors.initials: M
authors.lastname: Lascoux
authors.forename: M A
authors.initials: MA
authors.lastname: Newton
authors.forename: E V
authors.initials: EV
authors.lastname: Nordheim
mesh_terms: D000465:Algorithms; D001699:Biometry; D004777:Environment; D005804:Genes, Lethal; D017343:Genes, Plant; D008390:Markov Chains; D008957:Models, Genetic; D015233:Models, Statistical; D009010:Monte Carlo Method; D010944:Plants / Q000235:genetics*