title: Outdoor air pollutants derived from industrial processes may be causally related to the development of asthma in children.
abstract: BACKGROUND
  There is no consistent evidence that outdoor air pollutants are involved in the development of asthma.
  
  
  OBJECTIVE
  The aim of this study was to determine whether outdoor air pollutants derived from industrial processes were related to the prevalence of asthma, bronchial hyperresponsiveness, and atopy in exposed children.
  
  
  METHODS
  A total of 7,511 children from 7 to 12 years of age were recruited in the study. Eight hundred eighty-eight of 1,009 (88%) of the subjects living around industrial factories and 5,998 of 6,502 (92%) living in a less polluted neighboring area responded to the ISAAC questionnaire. A total of 1,492 subjects 8 to 9 years old underwent skin prick tests for 11 common aeroallergens. A total of 732 of the subjects from 8 to 9 years of age underwent bronchial provocation tests with hypertonic saline (BPT-HS).
  
  
  RESULTS
  The prevalence of ever experiencing wheezing and wheeze during the last 12 months was 25.6%, and 18.8% among the children living in the more polluted area. This was significantly higher than for those living in the less polluted area (14.2% and 9.0%, respectively). The positive rate of BPT-HS (the provocative dose of hypertonic saline causing 20% fall of FEV, < or = 23 mL) was higher among those in the more polluted area than in children living in the less polluted area (12.2% vs 7.5%). However, the rate of atopy based on the skin tests was the same in the two groups (28.3% vs 30.6%).
  
  
  CONCLUSIONS
  The prevalence of asthma and bronchial hyperresponsiveness was higher among children living around the heavily industrial area compared with those living in the less polluted area, despite similar atopic sensitization.
authors.affiliation: Department of Internal Medicine, Seoul National University College of Medicine, Korea.
authors.forename: Y K
authors.initials: YK
authors.lastname: Kim
authors.forename: D
authors.initials: D
authors.lastname: Baek
authors.forename: Y I
authors.initials: YI
authors.lastname: Koh
authors.forename: S H
authors.initials: SH
authors.lastname: Cho
authors.forename: I S
authors.initials: IS
authors.lastname: Choi
authors.forename: K U
authors.initials: KU
authors.lastname: Min
authors.forename: Y Y
authors.initials: YY
authors.lastname: Kim
mesh_terms: D000393:Air Pollutants / Q000009:adverse effects*; D000485:Allergens; D001249:Asthma / Q000453:epidemiology* / Q000209:etiology; D016535:Bronchial Hyperreactivity / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000209:etiology; D008297:Male; D015995:Prevalence; D012462:Saline Solution, Hypertonic; D012882:Skin Tests; D014504:Urban Health
chemical_list: D000393:Air Pollutants; D000485:Allergens; D012462:Saline Solution, Hypertonic