Genetic variants of the serotonin system and weight change during clozapine treatment.
Clozapine-induced weight gain may impair health and affect patient compliance. The aim of this study is to investigate the relationship between the genetic variants of the serotonin system and clozapine-induced body weight change (BWC). Ninety-three treatment-resistant schizophrenic patients were weighed monthly for 4 months during clozapine treatment. At the conclusion of treatment, patients had gained an average of 2.4 kg body weight, with BWC ranging from -17.5 to +12.9 kg. The levels of the serotonin transporter variants, serotonin 2A, serotonin 2C and serotonin 6, demonstrated no statistically significant relationship to BWC. Patients with a lower initial body mass index demonstrated a greater weight gain associated with clozapine treatment. Further exploration of the neurotransmitters implicated in the antipsychotic-induced BWC is important in order to reduce the morbidity and noncompliance associated with weight gain.
Hong
C J
CJ
Department of Psychiatry, Veterans General Hospital-Taipei, no. 201, Shih-Pal Road, Sec. 2, 11217, Taipei, Taiwan, ROC.
Lin
C H
CH
Yu
Y W
YW
Yang
K H
KH
Tsai
S J
SJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D015992:Body Mass Index; D002352:Carrier Proteins / Q000235:genetics*; D003024:Clozapine / Q000627:therapeutic use*; D005260:Female; D014644:Genetic Variation / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000235:genetics*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D011985:Receptors, Serotonin / Q000235:genetics*; D012307:Risk Factors; D012559:Schizophrenia / Q000188:drug therapy; D050486:Serotonin Plasma Membrane Transport Proteins; D015430:Weight Gain / Q000187:drug effects*
D014150:Antipsychotic Agents; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D011985:Receptors, Serotonin; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; D003024:Clozapine