title: Is preventive resection of the extrahepatic bile duct necessary in cases of pancreaticobiliary maljunction without dilatation of the bile duct?
abstract: BACKGROUND
  No consensus has been reached on whether preventive resection of the extrahepatic bile duct is necessary in cases of pancreaticobiliary maljunction (PBM) without dilatation of the extrahepatic bile duct (undilated type).
  
  
  METHODS
  Sixty-eight patients with PBM underwent corrective surgery and several clinical characteristics and pathological findings including K-ras point mutation were evaluated.
  
  
  RESULTS
  Unlike dilated bile duct, none of the patients with undilated type duct had clinical symptoms in early childhood. In patients with either cystic or spindle type duct, amylase levels in the bile duct were >10(4) U/l, whereas those in patients with undilated type duct were <10(4) U/l. Postoperative scintigraphy of the biliary system of undilated type revealed no evidence of cholestasis. After surgery, eight patients with undilated type duct, in whom the bile duct had been preserved, had no further clinical symptoms and no evidence of malignancy. Bile duct tissue specimens revealed no hyperplasia, dysplasia or cancerous lesions and they had no K-ras mutation in undilated type.
  
  
  CONCLUSIONS
  The results showed that there was little bile stasis, injury to the mucosa was mild and less genetic changes could be seen in patients with undilated type duct. Therefore, in patients without dilatation of bile duct and advanced cancer, cholecystectomy alone is sufficient.
authors.affiliation: Department of Surgery, Tokyo Medical University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Aoki
authors.forename: A
authors.initials: A
authors.lastname: Tsuchida
authors.forename: K
authors.initials: K
authors.lastname: Kasuya
authors.forename: M
authors.initials: M
authors.lastname: Endo
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: Y
authors.initials: Y
authors.lastname: Koyanagi
mesh_terms: D000328:Adult; D001650:Bile Duct Neoplasms / Q000517:prevention & control*; D001652:Bile Ducts / Q000473:pathology; D017734:Bile Ducts, Extrahepatic / Q000473:pathology / Q000601:surgery*; D001659:Biliary Tract / Q000002:abnormalities*; D002763:Cholecystectomy; D004108:Dilatation, Pathologic; D005704:Gallbladder / Q000473:pathology; D011905:Genes, ras / Q000235:genetics; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D009154:Mutation; D010179:Pancreas / Q000002:abnormalities*