title: Recent rheumatoid arthritis clinical trials using radiographic endpoints--updated research agenda.
abstract: Recent randomized controlled trials of traditional and newly developed therapies provide evidence that we have interventions that potentially slow or prevent structural damage in active rheumatoid arthritis, as measured using radiography. These trials also provide a unique opportunity for exploratory data analysis to generate hypotheses apropos the pathogenesis and determinants of radiographic progression and functional disability; they also facilitate further study of the methodological issues regarding imaging measurement.
authors.affiliation: Division of Immunology, Stanford University, San Francisco, CA 94028, USA. vstrand@aol.com
authors.forename: V
authors.initials: V
authors.lastname: Strand
authors.forename: M
authors.initials: M
authors.lastname: Lassere
authors.forename: D
authors.initials: D
authors.lastname: van der Heijde
authors.forename: K
authors.initials: K
authors.lastname: Johnson
authors.forename: M
authors.initials: M
authors.lastname: Boers
mesh_terms: D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000628:therapy*; D001175:Arthrography; D006801:Humans; D016032:Randomized Controlled Trials as Topic; D012107:Research Design