title: Intraadrenal mechanisms of DHEA regulation: a hypothesis for adrenopause.
abstract: Dehydroepiandrosterone (DHEA) and its sulfate metabolite DHEAS are the major androgens secreted by the human adrenal gland. The specific control of these hormones remains unclear. While ACTH is a potent stimulator of DHEA secretion, other factors both systemic and local have been involved in adrenal androgen control. Here we review the extra and intraadrenal regulation of DHEA and propose a hypothetical model for adrenal senescence.
authors.affiliation: Pediatric and Reproductive Endocrinology Branch, National Institute of Child Health, National Institutes of Health, Bethesda, MD 20892-1583, USA. alescis@mail.nih.gov
authors.forename: S
authors.initials: S
authors.lastname: Alesci
authors.forename: S R
authors.initials: SR
authors.lastname: Bornstein
mesh_terms: D000311:Adrenal Glands / Q000502:physiology*; D000375:Aging / Q000378:metabolism; D000728:Androgens / Q000378:metabolism; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological
chemical_list: D000728:Androgens; D003687:Dehydroepiandrosterone