Anti-HIV prenylated flavonoids from Monotes africanus.
Six flavonoids, among them a new dihydroflavonol, 6,8-diprenylaromadendrin (1), and the flavonol 6,8-diprenylkaempferol (3), have been isolated from the organic extract of Monotes africanus. The isolated compounds containing a 5,7-dihydroxy-6,8-diprenyl system in the A ring of the flavonoid (1, 3, and 6) exhibited HIV-inhibitory activity in the XTT-based, whole-cell screen. In addition, several (13)C NMR assignments of lonchocarpol A (6) were corrected.
Meragelman
K M
KM
Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, National Cancer Institute, NCI-Frederick, Frederick, Maryland 21702-1201, USA.
McKee
T C
TC
Boyd
M R
MR
D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification*; D005419:Flavonoids / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D019685:Rosales / Q000737:chemistry*; D013057:Spectrum Analysis
D019380:Anti-HIV Agents; D005419:Flavonoids