title: Nerve and fibroblast growth factors as modulators of pancreatic beta cell plasticity and insulin secretion.
abstract: Trophic factors such as nerve and fibroblast growth factors are important modulators of beta cell physiology. These two factors induce the extension of neurite-like processes in primary cultures of adult rat beta cells. Moreover, both NGF and FGF enhance glucose-induced insulin secretion. Since beta cells synthesize NGF and pancreatic islet cells produce FGFs, it is possible that autocrine/paracrine interactions may be major regulators of insulin secretion, and impairment of these interactions could lead to pathological states such as diabetes mellitus.
authors.affiliation: Department of Biophysics, Institute of Cellular Physiology, National Autonomous University of Mexico, Mexico City, Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Hiriart
authors.forename: R
authors.initials: R
authors.lastname: Vidaltamayo
authors.forename: M C
authors.initials: MC
authors.lastname: Sánchez-Soto
mesh_terms: D000704:Analysis of Variance; D002468:Cell Physiological Phenomena / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D005346:Fibroblast Growth Factors / Q000502:physiology*; D006801:Humans; D007155:Immunologic Factors; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000502:physiology*; D008297:Male; D020932:Nerve Growth Factor / Q000502:physiology*; D011336:Probability; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D007155:Immunologic Factors; D007328:Insulin; D005346:Fibroblast Growth Factors; D020932:Nerve Growth Factor