[Diagnostic criteria of carbohydrate metabolism disorders in pulmonary tuberculosis complicated by diabetes mellitus in patients with various haptoglobin phenotypes].
A total of 180 patients with various haptoglobin (Hp) phenotypes were examined in order to detect specific features of carbohydrate metabolism disorders in pulmonary tuberculosis concomitant with diabetes mellitus. Blood sugar levels, G-6-PDH and LDH, acid-base balance, and 2,3-DPG and HbA1c were evaluated. LDH activity was decreased 1.3-1.7 times in comparison with the norm, G-6-PDH was decreased by 15-45% vs. the norm in 87% patients, acid-base status was imbalanced, HbA1c content was increased 1.5-1.7 times vs. the norm, and 2.3-DPG content was increased 2-3-fold in comparison with the norm in 83% patients. Increased levels of HbA1c and 2,3-DPG in the studied combination of diseases augmented disorders of O2 binding to hemoglobin, which led to hypoxia. The most pronounced shifts in the studied parameters were observed in patients with Hp 2-2 and Hp 1-1. Changes in the studied parameters should be used for the diagnosis of the severity of carbohydrate metabolism disorders in diabetics with pulmonary tuberculosis.
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Kazakov
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D050260:Carbohydrate Metabolism; D004796:Clinical Enzyme Tests; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000235:genetics / Q000378:metabolism*; D006242:Haptoglobins / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000235:genetics / Q000378:metabolism*
D006242:Haptoglobins