title: Prolonged iron depletion after allogeneic 2-unit RBC apheresis.
abstract: BACKGROUND
  Allogeneic 2-unit RBC apheresis is a safe procedure offering many advantages for donors and blood banks. A controlled study was performed to determine whether the recommended minimum interval of 4 months between 2-unit RBC apheresis donations is appropriate in terms of the recovery of RBCs and the regeneration of iron stores.
  
  
  METHODS
  Twenty male subjects each donated 2 units of RBCs by apheresis. The RBC count, reticulocyte count, EPO, and measures of iron status were analyzed before and during the 4 months after donation.
  
  
  RESULTS
  A significant decrease in Hb (15.89 +/- 0.82 [mean +/- SD] vs. 14.08 +/- 0.97 mg/dL, baseline vs. Day 7; p<0.001) was equalized within 2 months. In contrast, ferritin values declined significantly from 54.2 +/- 33.7 to 23.42 +/- 21.94 microg per L (predonation vs. Day 30) and remained significantly below predonation values, but within the normal range, until the end of the study period.
  
  
  CONCLUSIONS
  A donation interval of 4 months is appropriate in terms of RBC recovery, but may not be appropriate in terms of iron store regeneration. The tendency to shorten the donation interval should be reconsidered in light of the measurements of iron storage. The use of ferritin levels is recommended as a preselection criterion for allogeneic 2-unit RBC apheresis.
authors.affiliation: Departments of Transfusion Medicine, Biostatistics and Documentation, and Anaesthesia, University of Innsbruck, Innsbruck, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Högler
authors.forename: W
authors.initials: W
authors.lastname: Mayer
authors.forename: C
authors.initials: C
authors.lastname: Messmer
authors.forename: G
authors.initials: G
authors.lastname: Eibl
authors.forename: P
authors.initials: P
authors.lastname: Innerhofer
authors.forename: D
authors.initials: D
authors.lastname: Schönitzer
authors.forename: W
authors.initials: W
authors.lastname: Nussbaumer
mesh_terms: D000328:Adult; D000368:Aged; D001781:Blood Component Removal; D001782:Blood Donors; D017707:Erythrocyte Transfusion; D004921:Erythropoietin / Q000096:biosynthesis; D005293:Ferritins / Q000097:blood; D006801:Humans; D007501:Iron / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014168:Transferrin / Q000032:analysis
chemical_list: D014168:Transferrin; D004921:Erythropoietin; D005293:Ferritins; D007501:Iron