Pathophysiology of microcirculation in venous disease.
Microcirculatory disturbances lead to chronic ulceration of the leg, and this symptom is a sign of a chronic venous insufficiency (CVI), caused by increased leg vein pressure and continous changes in vein pressure, which need medical treatment, and if a chronic capillary reaction present, treatment by applying a graduated compression bandage of the leg is mandatory. Subcutaneous tissue hypoxaemia and interstitial edema lead to worsening of the ulcer and need intensive and systematic wound care, because unhealed chronic wound with trophic changes of the skin is the major cause of further CVI changes of the leg. As chronic venous disease has complex etiologic basis, it needs diagnostics and treatment modality based on various approaches, and that microcirculatory pathophysiological approach should be considered in all kinds of the treatment of chronic venous insufficiency. Microcirculation pathology should be used as an approach in the treatment regiment of CVI, whilst the basic pathophysiology of the venous diseases, which is known as one of the causes of CVI. This approach will give better results of treatment and other pathologic disturbances which were caused by chronic vitious circle chain processes.
Puruhito
Department of Surgery, Faculty of Medicine, Airlangga University, Surabaya, Indonesia.
D001458:Bandages; D002908:Chronic Disease; D004487:Edema / Q000209:etiology / Q000503:physiopathology; D018056:Hemorheology; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000503:physiopathology; D007866:Leg / Q000098:blood supply*; D007871:Leg Ulcer / Q000209:etiology / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D008833:Microcirculation; D015911:Sclerotherapy; D013924:Thrombophlebitis / Q000503:physiopathology; D014648:Varicose Veins / Q000503:physiopathology / Q000601:surgery / Q000628:therapy; D014656:Vascular Surgical Procedures; D014689:Venous Insufficiency / Q000150:complications / Q000503:physiopathology*