title: Interferon-alpha combined with radiotherapy in the treatment of unresectable melanoma.
abstract: A case of recurrent and twice resected sinonasal melanoma is presented. The large recurrent tumor was found to regress by a concurrent combination of 6660 cGy photon radiation and subcutaneous interferon-alpha injections given for a period of 8 weeks. Possible mechanisms of potentiation between interferon and radiation are discussed. The unexpected result in this case report raises interesting questions about this treatment combination.
authors.affiliation: Department of Radiation/Oncology, Southwestern University, Dallas, Texas, USA. NamPhong.Nguyen@med.va.gov
authors.forename: N P
authors.initials: NP
authors.lastname: Nguyen
authors.forename: S
authors.initials: S
authors.lastname: Sallah
authors.forename: C
authors.initials: C
authors.lastname: Childress
authors.forename: M R
authors.initials: MR
authors.lastname: Salehpour
authors.forename: U
authors.initials: U
authors.lastname: Karlsson
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006801:Humans; D016898:Interferon-alpha / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000532:radiotherapy; D010255:Paranasal Sinus Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha