[Combined therapy of experimental tumors with the vaccinal strain of Venezulean encephalomyelitis virus].
The potential of therapy with vaccinal strain of Venezuelan encephalomyelitis virus (VEL) in conjunction with cytostatics (cyclophosphamide) or immunomodulators (T-activin) has been studied. It was found that VEL in conjunction with cyclophosphamide inhibited the antitumor action of the drugs while T-activin potentiated the same effects of the virus and its oncolysate.
Urazova
L N
LN
Research Institute of Oncology, Research Center, Russian Academy of Medical Sciences, Siberian Branch, Tomsk.
Gromova
A I
AI
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004666:Encephalitis Virus, Venezuelan Equine / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000188:drug therapy* / Q000276:immunology; D010455:Peptides / Q000494:pharmacology*; D013949:Thymus Extracts / Q000494:pharmacology*; D014765:Viral Vaccines / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D018906:Antineoplastic Agents, Alkylating; D010455:Peptides; D013949:Thymus Extracts; D014765:Viral Vaccines; C036191:T-activin; D003520:Cyclophosphamide