Bryn Bridges and mutagenesis: exploring the intellectual space.
The products of the SOS-regulated umuDC genes are required for most UV and chemical mutagenesis in Escherichia coli. Recently it has been recognized that UmuC is the founding member of a superfamily of novel DNA polymerases found in all three kingdoms of life. Key findings leading to these insights are reviewed, placing a particular emphasis on contributions made by Bryn Bridges and on his interest in the importance of interactions between the umuDC gene products and the replicative DNA polymerase.
Walker
G C
GC
Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA. gwalker@mit.edu
D001426:Bacterial Proteins / Q000235:genetics; D004249:DNA Damage; D004259:DNA-Directed DNA Polymerase; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial; D049673:History, 20th Century; D008957:Models, Genetic; D016296:Mutagenesis; D013014:SOS Response, Genetics / Q000235:genetics; D014466:Ultraviolet Rays / Q000009:adverse effects
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C078202:UmuC protein, E coli; D004259:DNA-Directed DNA Polymerase; C055218:UmuD protein, E coli