Radiographic resolution of lymphocytic interstitial pneumonitis (LIP) in children with human immunodeficiency virus (HIV): not a sign of clinical deterioration.
BACKGROUND
The literature and anecdotal evidence associate the resolution of radiographic findings of lymphocytic interstitial pneumonitis (LIP) with a decline in immune and clinical status of human immunodeficiency virus (HIV) infected children.


OBJECTIVE
As our clinical impression was the opposite, we sought to elucidate this contradiction.


METHODS
Of 52 pediatric patients infected with the HIV currently being followed at our institution, 20 (38.5%) carried the diagnosis of LIP and 13 (65%) of these have had complete resolution of radiographic findings of LIP. We retrospectively reviewed the chest radiographs, CD4 counts, and clinical history of these 13 patients.


RESULTS
Of the 13 patients who had resolution of radiographic findings, 11 (84.6%) had no significant change in CD4 count at the time of resolution and remained clinically stable during a mean follow-up period of 32 months. Two patients (15.3%) developed severe CD4 lymphocytopenia at the time of resolution of LIP, but clinically remained stable. None of these 13 patients had a recurrence of LIP, even with subsequent increases in CD4 count.


CONCLUSIONS
We suggest that in contradiction to previously published data, resolution of LIP on chest radiographs is not an indicator for poor prognosis for the HIV-infected pediatric patient.
Lynch
J L
JL
Department of Radiology, Boston Medical Center, Boston University School of Medicine, 1 BMC Place, Boston, MA 02118, USA.
Blickman
J G
JG
terMeulen
D C
DC
Babl
F E
FE
Moloney
C H
CH
Pelton
S I
SI
D018791:CD4 Lymphocyte Count; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000000981:diagnostic imaging* / Q000276:immunology; D006801:Humans; D007223:Infant; D017563:Lung Diseases, Interstitial / Q000000981:diagnostic imaging* / Q000276:immunology; D008297:Male; D011379:Prognosis; D011859:Radiography