[Kinetics of in vitro drug release from chitosan and N-alkyl chitosan membranes].
By using the so-called "lag-time" method, we studied the effect of membrane thickness(h), initial drug concentration(Co) and flow rate(V) on the difusion coefficient(D) of model drug in membranes. The experiment indicates that D increases as h and v increase; D Keeps constant when C0 changes; Under the same condition, the D value of N-alkyl chitosan membrane is bigger than that of pure chitosan membrane.
Li
M
M
Research Institute of Polymeric Materials, Tianjin University, Tianjin 300072.
Xin
M
M
Wang
Q
Q
Yao
K
K
D002686:Chitin / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D048271:Chitosan; D004058:Diffusion; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D020160:Sodium Benzoate / Q000493:pharmacokinetics*; D013997:Time Factors
D008567:Membranes, Artificial; D002686:Chitin; D048271:Chitosan; D020160:Sodium Benzoate