Synthesis and biochemical evaluation of some novel N-acyl phosphono- and phosphinoalanine derivatives as potential inhibitors of the D-glutamic acid-adding enzyme.
A series of N-(5-phthalimidopentanoyl)-, N-[2-(2-ethoxy)acetyl]-, and N-(7-oxooctanoyl)-phosphono and phosphinoalanine derivatives has been synthesized and evaluated for inhibition of the D-glutamic acid-adding enzyme (MurD) of peptidoglycan biosynthesis.
Gobec
S
S
Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. gobecs@ffa.uni-lj.si
Urleb
U
U
Auger
G
G
Blanot
D
D
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000737:chemistry; D000409:Alanine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents
D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000409:Alanine