Control of glomerular capillary development by growth factor/receptor kinases.
Multiple signaling processes, including cell-matrix and cell-cell interactions, and growth factor/receptor binding, are crucially important for guiding blood vessel formation. Here we summarize current data, much of which has been obtained recently from gene targeting in mice, on the roles played by the growth factor ligand/ receptor tyrosine kinase systems represented by: vascular endothelial growth factor (VEGF) and its receptors; Eph/Ephrins; Tie1, Tie2 and angiopoietins; and platelet-derived growth factor (PDGF) in glomerular capillary development. A fundamental understanding of glomerular endothelial growth and differentiation during organogenesis may provide clues for stimulating glomerular repair after toxic injury or ischemia.
Robert
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Department of Anatomy and Cell Biology, University of Kansas Medical Center, Kansas City 66160-7400, USA.
Abrahamson
D R
DR
D000818:Animals; D002196:Capillaries / Q000254:growth & development*; D006133:Growth Substances / Q000502:physiology*; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply* / Q000254:growth & development*; D018919:Neovascularization, Physiologic / Q000502:physiology*; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D017978:Receptors, Growth Factor / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology
D006133:Growth Substances; D017978:Receptors, Growth Factor; D020794:Receptor Protein-Tyrosine Kinases