title: Association between mu opioid receptor gene polymorphisms and Chinese heroin addicts.
abstract: Mu opioid receptor (MOR) has been shown to be associated with alcoholism and opioid dependence. The present study examined the involvement of a polymorphism in A118G in exon 1 and C1031G in intron 2 of the MOR gene in 200 Chinese heroin-dependent and 97 control subjects. Results showed a significant association for both A118G and C1031G polymorphisms and opioid dependence. The G allele is more common in the heroin-dependent group (39.5% and 30.8% for A118G and C1031G polymorphisms, respectively) when compared to the controls (29.4% and 21.1% for A118G and C1031G polymorphisms, respectively). This study suggests that the variant G allele of both A118G and C1031G polymorphisms may contribute to the vulnerability to heroin dependence.
authors.affiliation: Department of Anatomy, Chinese University of Hong Kong, Shatin, N.T., Hong Kong, China.
authors.forename: C Y
authors.initials: CY
authors.lastname: Szeto
authors.forename: N L
authors.initials: NL
authors.lastname: Tang
authors.forename: D T
authors.initials: DT
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Stadlin
mesh_terms: D000328:Adult; D044466:Asian People / Q000235:genetics*; D016009:Chi-Square Distribution; D005091:Exons / Q000235:genetics; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006556:Heroin Dependence / Q000235:genetics*; D006801:Humans; D007438:Introns / Q000235:genetics; D016015:Logistic Models; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D017450:Receptors, Opioid, mu / Q000235:genetics*
chemical_list: D017450:Receptors, Opioid, mu