SRY-negative XX sex reversal in a pony: a case report.
A three year old pony with sexually ambiguous external genitalia was found to have a normal female karyotype (64, XX) and bilateral inguinal testes. The PCR analysis of blood samples revealed the absence of the Y chromosome sequences SRY, eTSPY and ZFY. No Y chromosome sequences were identified in DNA extracted from the gonads. The mechanism whereby XX sex reversal occurs in the absence of SRY is unknown.
Vaughan
L
L
Faculty of Veterinary Medicine, University College Dublin, Ballsbridge, Ireland.
Schofield
W
W
Ennis
S
S
D000818:Animals; D004268:DNA-Binding Proteins / Q000097:blood / Q000235:genetics*; D012734:Disorders of Sex Development / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D005260:Female; D006736:Horses / Q000502:physiology*; D008297:Male; D009687:Nuclear Proteins; D009919:Orchiectomy; D051876:Sex-Determining Region Y Protein; D013737:Testis / Q000473:pathology / Q000601:surgery; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051876:Sex-Determining Region Y Protein; D014157:Transcription Factors