A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction.
OBJECTIVE
To compare the rates of ovulation and pregnancy after tamoxifen citrate (TMX) or clomiphene citrate (CC) among anovulatory women with infertility.


METHODS
Prospective randomized trial.


METHODS
Infertility clinic in a university teaching hospital.


METHODS
Eighty-six anovulatory women under 40 years of age undergoing ovulation induction.


METHODS
The women were assigned randomly to receive either TMX or CC on cycle days 5-9.


METHODS
Rates of ovulation and pregnancy for the two treatment modalities.


RESULTS
The overall rate of ovulation in the TMX group was 50 of 113 (44.2%) and in the CC group, 41 of 91 (45.1%). There were 10 pregnancies in the TMX group and 6 pregnancies in the CC group. The cycle fecundity per ovulatory cycle was 20.0% in the TMX group and 14.6% in the CC group.


CONCLUSIONS
The overall rate of ovulation and pregnancy were similar with TMX and CC. TMX is a suitable alternative agent to CC in the management of anovulatory infertility.
Boostanfar
R
R
Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
Jain
J K
JK
Mishell
D R
DR
Paulson
R J
RJ
D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000652:urine; D008297:Male; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage / Q000627:therapeutic use*; D013629:Tamoxifen / Q000008:administration & dosage / Q000627:therapeutic use*
D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D002996:Clomiphene; D007986:Luteinizing Hormone