title: Effect of Ukrain on human liver alcohol dehydrogenase activity in vitro.
abstract: In the present study it was found that Ukrain inhibits the ethanol oxidation process catalyzed by human alcohol dehydrogenase (ADH). Ukrain at a concentration of 10(-6), 2.5 x 10(-6), and 5.0 x 10(-6) M decreased liver ADH activity in the presence ethanol (approximately 8.41%, 13.28%, 16.69%, respectively) as well as in the presence of methanol (approximately 13.29%, 19.07% and 42.20%, respectively).
authors.affiliation: Department of Toxicology, University Medical School, Chodki 7, 20-093 Lublin, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
authors.forename: J
authors.initials: J
authors.lastname: Dudka
authors.forename: K
authors.initials: K
authors.lastname: Dawidek-Pietryka
mesh_terms: D000328:Adult; D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000470:Alkaloids / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001600:Berberine Alkaloids; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D000432:Methanol / Q000494:pharmacology; D009243:NAD / Q000378:metabolism; D010617:Phenanthridines
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001600:Berberine Alkaloids; D010617:Phenanthridines; D009243:NAD; D000431:Ethanol; C060921:ukrain; D000426:Alcohol Dehydrogenase; D000432:Methanol