New triterpenes, myrrhanol A and myrrhanone A, from guggul-gum resins, and their potent anti-inflammatory effect on adjuvant-induced air-pouch granuloma of mice.
Myrrhanol A, a new triterpene isolated from guggul (Balsamodendron or Commiphora mukul Hook.)-gum resin, displays a potent anti-inflammatory effect on exudative pouch fluid, angiogenesis, and granuloma weights in adjuvant-induced air-pouch granuloma of mice. Its effects were more marked than those of hydrocortisone and the 50% aqueous methanolic extract of the crude drug. Myrrhanol A is a plausible candidate for a potent anti-inflammatory agent.
Kimura
I
I
Department of Clinical Pharmacology, Graduate School of Pharmaceutical Sciences, Toyama Medical and Pharmaceutical University, Sugitani, Japan. ikukokim@ms.toyama-mpu.ac.jp
Yoshikawa
M
M
Kobayashi
S
S
Sugihara
Y
Y
Suzuki
M
M
Oominami
H
H
Murakami
T
T
Matsuda
H
H
Doiphode
V V
VV
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D002329:Carmine / Q000032:analysis; D002465:Cell Movement / Q000187:drug effects; D029744:Commiphora; D004305:Dose-Response Relationship, Drug; D005122:Exudates and Transudates / Q000187:drug effects*; D005620:Freund's Adjuvant; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D010936:Plant Extracts / Q000737:chemistry; D053149:Plant Gums; D013729:Terpenes / Q000494:pharmacology / Q000627:therapeutic use; D014315:Triterpenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D053149:Plant Gums; D013729:Terpenes; D014315:Triterpenes; C434796:myrrhanol A; C434795:myrrhanone A; C018562:guggulu extract; D005620:Freund's Adjuvant; D002329:Carmine; C014119:myrrh oil