title: Reduction in atrial defibrillation threshold by a single linear ablation lesion.
abstract: BACKGROUND
  This study investigated a hybrid approach to reduce the atrial defibrillation threshold (ADFT) by determining the effect of a single linear radiofrequency ablation (RFA) lesion on both the ADFT and activation patterns during atrial fibrillation (AF).
  
  
  RESULTS
  In 18 open chest sheep (45 to 57 kg), coil defibrillation electrodes were placed in a superior vena cava/right ventricular configuration. AF was induced by burst pacing and maintained with acetyl beta-methylcholine (2 to 42 microL/min). ADFTs were obtained before and after a linear RFA lesion was created in the left atrium (LAL; n = 6), right atrium (RAL; n = 6), or neither atrium as a control (n = 6). In animals receiving an LAL, a 504-unipolar-electrode plaque was sutured to the LA. For animals receiving an RAL, two 504-electrode plaques were placed, one each on the LA and RA. From each plaque, activations were recorded before and after ADFT shocks, and organizational characteristics of activations were analyzed using algorithms that track individual wavefronts. In sham-treated controls, the ADFT did not change. In contrast, LAL reduced ADFT energy 29%, from 4.5 +/- 2.3 J to 3.2 +/- 2.0 J (P < 0.05). RAL reduced ADFT energy 25%, from 2.0 +/- 0.9 J to 1.5 +/- 0.7 J (P < 0.05). AF activation was substantially more organized after RFA than before RFA for both the RAL- and LAL-treated animals.
  
  
  CONCLUSIONS
  A single RFA lesion in either the RA or LA reduces the ADFT in this sheep model. This decrease is associated with an increase in fibrillatory organization.
authors.affiliation: Department of Biomedical Engineering, The University of Alabama at Birmingham, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: White
authors.forename: P C
authors.initials: PC
authors.lastname: Fotuhi
authors.forename: R W
authors.initials: RW
authors.lastname: Pedoto
authors.forename: N
authors.initials: N
authors.lastname: Chattipakorn
authors.forename: J M
authors.initials: JM
authors.lastname: Rogers
authors.forename: R E
authors.initials: RE
authors.lastname: Ideker
mesh_terms: D000818:Animals; D001281:Atrial Fibrillation / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy*; D016279:Atrial Function, Left; D016280:Atrial Function, Right; D017115:Catheter Ablation; D004056:Differential Threshold; D004554:Electric Countershock; D005260:Female; D008297:Male; D012756:Sheep; D016896:Treatment Outcome