title: Esophagogastric dissociation versus fundoplication: Which is best for severely neurologically impaired children?
abstract: OBJECTIVE
  Neurologically impaired children (NIC) often have swallowing difficulties, severe gastroesophageal reflux, recurrent respiratory infections, and malnutrition. Bianchi proposed esophagogastric dissociation (EGD) as an alternative to fundoplication and gastrostomy. The authors compared these 2 approaches.
  
  
  METHODS
  Twenty-nine consecutive symptomatic NIC refractory to medical therapy were enrolled in a prospective study and divided into 2 groups: A (n = 12), NIC who underwent fundoplication and gastrostomy; B (n = 14), NIC who underwent EGD. Three were excluded because of previous fundoplication. Anthropometric (percentage of the 50th percentile/age of healthy children) and biochemical parameters, respiratory infections per year, hospitalization (days per year), feeding time (minutes), and "quality of life" (parental psychological questionnaire, range 0 to 60), were analyzed (t test and Mann-Whitney test) preoperatively and 1 year postoperatively. Complications were recorded.
  
  
  RESULTS
  Compared with group A, group B presented a statistically significant increase of all anthropometric and nearly all biochemical parameters with a statistical difference in terms of respiratory infections, hospital stay, feeding time, and psychological questionnaire. In group A, 2 bowel obstructions, 1 tight fundoplication, 1 dumping syndrome, and 3 failures of fundoplication occurred. Group B presented 1 anastomotic stricture, 1 paraesophageal hernia, and 1 bowel obstruction.
  
  
  CONCLUSIONS
  Compared with fundoplication and gastrostomy, EGD offered better nutritional rehabilitation, reduction in respiratory infections, and improved quality of life. EGD can be rightfully chosen as a primary procedure.
authors.affiliation: Digestive Surgery Unit, Bambino Gesù Children's Hospital, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Gatti
authors.forename: G F
authors.initials: GF
authors.lastname: di Abriola
authors.forename: M
authors.initials: M
authors.lastname: Villa
authors.forename: P
authors.initials: P
authors.lastname: De Angelis
authors.forename: R
authors.initials: R
authors.lastname: Laviani
authors.forename: E
authors.initials: E
authors.lastname: La Sala
authors.forename: L
authors.initials: L
authors.lastname: Dall'Oglio
mesh_terms: D000293:Adolescent; D000886:Anthropometry; D002648:Child; D015362:Child Nutrition Disorders / Q000097:blood / Q000175:diagnosis / Q000209:etiology* / Q000523:psychology / Q000601:surgery*; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000150:complications*; D018662:Fundoplication / Q000009:adverse effects / Q000523:psychology; D005764:Gastroesophageal Reflux / Q000209:etiology* / Q000523:psychology / Q000601:surgery*; D005774:Gastrostomy / Q000009:adverse effects / Q000523:psychology; D006801:Humans; D007223:Infant; D007902:Length of Stay / Q000706:statistics & numerical data; D015596:Nutrition Assessment; D018579:Patient Selection; D011446:Prospective Studies; D011788:Quality of Life; D012141:Respiratory Tract Infections / Q000209:etiology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome