title: Treatment of Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli by oral administration of praziquantel in combination with cimetidine.
abstract: The effect of cimetidine on the treatment efficacy of praziquantel against Microcotyle sebastis infestation in cultured rockfish Sebastes schlegeli was investigated. Juvenile rockfish were divided into 7 groups, and orally administered praziquantel alone (50, 100 and 200 mg kg(-1) body wt, BW) or in combination with cimetidine at a dose of 200 mg kg(-1) BW for each praziquantel dose. The fish in the control group were administered only saline. The results clearly showed that coadministration of cimetidine with praziquantel led to a significantly increased treatment efficacy of the latter drug, and consequently would lead to a lowering of the total dose of praziquantel, and a reduction in the administration times and costs for the treatment of M. sebastis infestation in cultured rockfish.
authors.affiliation: Department of Aquatic Life Medicine, College of Fisheries Science, Pukyong National University, Pusan, Korea. khkim@dolphin.pknu.ac.kr
authors.forename: K H
authors.initials: KH
authors.lastname: Kim
authors.forename: E H
authors.initials: EH
authors.lastname: Lee
authors.forename: S R
authors.initials: SR
authors.lastname: Kwon
authors.forename: J B
authors.initials: JB
authors.lastname: Cho
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D017756:Aquaculture; D002590:Cestode Infections / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005393:Fish Diseases / Q000188:drug therapy*; D005399:Fishes; D007723:Korea / Q000453:epidemiology; D010986:Platyhelminths; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D015995:Prevalence
chemical_list: D000871:Anthelmintics; D011223:Praziquantel; D002927:Cimetidine