title: Synthesis of C-5'-alkyl substituted 17-spirofuran 19-norsteroids.
abstract: A number of new steroidal 17-spirofuran derivatives of the 19-nor series containing Me, Et or (i)Pr-substituents in the heterocyclic moiety has been prepared, which are expected to have a strong progestagenic activity. The proposed approach made use of the 1-3-dipolar cycloaddition of low-molecular nitrile oxides with steroidal acetylenic alcohols followed by transformation of the isoxazole side chain.
authors.affiliation: Institute of Bioorganic Chemistry, National Academy of Sciences of Belarus, Kuprevich str., 5/2, 220141, Minsk, Belarus. khripach@ns.iboch.ac.by
authors.forename: V A
authors.initials: VA
authors.lastname: Khripach
authors.forename: V N
authors.initials: VN
authors.lastname: Zhabinskii
authors.forename: D N
authors.initials: DN
authors.lastname: Tsavlovskii
authors.forename: O A
authors.initials: OA
authors.lastname: Drachenova
authors.forename: G V
authors.initials: GV
authors.lastname: Ivanova
authors.forename: O V
authors.initials: OV
authors.lastname: Konstantinova
authors.forename: M I
authors.initials: MI
authors.lastname: Zavadskaya
authors.forename: A S
authors.initials: AS
authors.lastname: Lyakhov
authors.forename: A A
authors.initials: AA
authors.lastname: Govorova
authors.forename: M B
authors.initials: MB
authors.lastname: Groen
authors.forename: A
authors.initials: A
authors.lastname: de Groot
mesh_terms: D000818:Animals; D005663:Furans / Q000138:chemical synthesis; D006801:Humans; D009654:Norsteroids / Q000138:chemical synthesis*; D011374:Progesterone / Q000031:analogs & derivatives; D013141:Spiro Compounds / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
chemical_list: D005663:Furans; D009654:Norsteroids; D013141:Spiro Compounds; D011374:Progesterone