title: Activities of cholic acid-derived antimicrobial agents against multidrug-resistant bacteria.
abstract: Cationic cholic acid derivatives displayed potent and broad-spectrum activity against multidrug-resistant Gram-negative and -positive bacteria. Specific examples were effective permeabilizers of the outer membranes of many strains of multidrug-resistant Gram-negative bacteria and sensitized these to hydrophobic antibiotics. We also prepared a new cholic acid derivative with improved apparent selectivity for prokaryote membranes.
authors.affiliation: Department of Microbiology, Brigham Young University, Provo, UT 84602, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Schmidt
authors.forename: J S
authors.initials: JS
authors.lastname: Boswell
authors.forename: J P
authors.initials: JP
authors.lastname: Walsh
authors.forename: M M
authors.initials: MM
authors.lastname: Schellenberg
authors.forename: T W
authors.initials: TW
authors.lastname: Winter
authors.forename: C
authors.initials: C
authors.lastname: Li
authors.forename: G W
authors.initials: GW
authors.lastname: Allman
authors.forename: P B
authors.initials: PB
authors.lastname: Savage
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D019826:Cholic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D012486:Salmonella typhimurium / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D019826:Cholic Acid