Duration of clinical symptoms in female patients with acute urethral syndrome caused by Chlamydia trachomatis treated with azithromycin or doxycycline.
One hundred fifty-one female patients with acute urethral syndrome caused by Chlamydia trachomatis were examined. First, patients were divided into two groups, those with clinical symptoms present < 3 weeks before the start of treatment, and those with clinical symptoms > or = 3 weeks prior to the beginning of therapy. Then patients were further divided into groups and randomized to receive azithromycin once daily in a single dose of 1.0 g or 500 mg once daily for 6 days, or to receive doxycycline 100 mg b.i.d. for 14 days or 100 mg b.i.d. for 7 days (8 study groups in all). Clinical and bacteriological efficacy was evaluated 3 weeks after the end of therapy. In the group of patients with disease symptoms lasting for 3 weeks or longer, the eradication and clinical cure rates were significantly higher after administration of azithromycin in a dose of 1x500 mg/6 days than after a single dose of 1.0 g (p<0.01), and after administration of doxycycline 2x100 mg/14 days than by using doxycycline 2x100 mg/7 days (p<0.05).
Skerk
V
V
University Hospital for Infectious Diseases Dr. Fran Mihaljević, Zagreb, Croatia. bfm@fran.bfm.hr
Schönwald
S
S
Strapac
Z
Z
Beus
A
A
Francetić
I
I
Krhen
I
I
Lesko
V
V
Vuković
J
J
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D017963:Azithromycin / Q000008:administration & dosage / Q000494:pharmacology*; D002690:Chlamydia Infections / Q000150:complications / Q000188:drug therapy*; D002692:Chlamydia trachomatis / Q000472:pathogenicity*; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008875:Middle Aged; D013577:Syndrome; D016896:Treatment Outcome; D014522:Urethral Diseases / Q000188:drug therapy / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D017963:Azithromycin; D004318:Doxycycline