[Prognostic value assessment of the early response of blood estradiol, FSH, and LH using leuprolide acetate during ovarian hyperstimulation in assisted reproduction].
OBJECTIVE
Evaluate the prognostic value of the early response of the serum estradiol FSH y LH action of leuprolide acetate during the folicular phase, used as an adjuvant to ovarian stimulation in IVF-ET.


METHODS
Were analyzed 31 cycles of stimulation in 26 patients with sterility primary and secondary. Where measured estradiol, FSH, LH on cycle day 2 to 5 for to establish the patterns of response to GnRHa administration. Were compared the response patterns in relation to the number of oocyte captured, estradiol in the day of application of hCG, number of embryos and fertilization rate using (t-student, wilcoxon test and X2).


RESULTS
Where observed four distincts patterns of response of estradiol. Pattern A: 133 cycles, presented a prompt elevation of estradiol, followed by a fall on the 4th cycle's day. Pattern B: 9 cycles delayed elevation of the estradiol, followed by a fall on the 6th cycles day. Pattern C: 7 cycles showed persistent elevation of the estradiol. Pattern D: 2 cycles no response of the estradiol (canceled cycles). Was found a significative difference in the estradiol level the day of application of hCG, number of captured oocytes and number of embrions in the pattern A in relation with B and C. No significative difference were found in the fertilization rate. The seric level of FSH and LH were no predictives. We concluded that the response pattern of the estradiol to the leuprolide acetate is the good prognosis indicator of the results of IVF-ET.
Sondón García
Z
Z
Alvarado
A
A
Peraza Briones
C
C
González Sánchez
R
R
Jiménez Perea
L
L
D000328:Adult; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D016729:Leuprolide / Q000627:therapeutic use*; D007986:Luteinizing Hormone / Q000097:blood*; D010062:Ovulation Induction / Q000379:methods*; D011379:Prognosis; D013997:Time Factors
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide