Whole organ transplantation and glucose regulation.
Pancreas transplantation has gained clinical acceptance since its initial application more than 30 years ago. A constellation of surgical, pharmacologic, and metabolic alterations occur with transplantation, particularly if pancreatic transplantation is performed in addition to renal transplantation in a uremic diabetic. Increasingly sophisticated studies have allowed analysis of the performance of the transplanted organ and have enhanced our basic understanding of insulin's complex interplay in peripheral glucoregulatory processes.
Wideman
L
L
Department of Exercise and Sports Medicine, University of North Carolina-Greensboro, 100 Spring Garden, Greensboro, North Carolina 27412, USA.
Elahi
D
D
Hanks
J
J
D000273:Adipose Tissue / Q000502:physiology; D000818:Animals; D003327:Coronary Disease / Q000453:epidemiology; D017079:Exercise Tolerance / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D051275:Glucose Transporter Type 4; D006706:Homeostasis; D006801:Humans; D006946:Hyperinsulinism / Q000503:physiopathology; D008066:Lipolysis; D009004:Monosaccharide Transport Proteins / Q000502:physiology; D009124:Muscle Proteins; D018482:Muscle, Skeletal / Q000378:metabolism; D016035:Pancreas Transplantation / Q000502:physiology*
D051275:Glucose Transporter Type 4; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495692:SLC2A4 protein, human; D005947:Glucose