title: Regional and temporal progression of reactive astrocytosis in the brain of the myelin mutant taiep rat.
abstract: Reactive astrocytosis in taiep rats was shown by glial fibrillary acidic protein (GFAP) immunoreactivity measured by means of enzyme-linked immunosorbent assay and indirect immunofluorescence. Increased GFAP immunoreactivity was first observed in the brainstem of 15-day-old taiep rats and was widespread throughout all brain regions at 6 months of age. Characteristically, astrocytes were hypertrophic and displayed strong GFAP fluorescence. The pattern of these reactive cells may correlate with the process of dysmyelination in the taiep rat.
authors.affiliation: Departamento de Fisiología, Biofísica y Neurociencias, CINVESTAV-IPN, Apartado postal 14-740, 07000 D.F., México, Mexico.
authors.forename: B A
authors.initials: BA
authors.lastname: Leon Chavez
authors.forename: J
authors.initials: J
authors.lastname: Guevara
authors.forename: S
authors.initials: S
authors.lastname: Galindo
authors.forename: J
authors.initials: J
authors.lastname: Luna
authors.forename: A
authors.initials: A
authors.lastname: Ugarte
authors.forename: O
authors.initials: O
authors.lastname: Villegas
authors.forename: R
authors.initials: R
authors.lastname: Mena
authors.forename: J R
authors.initials: JR
authors.lastname: Eguibar
authors.forename: D
authors.initials: D
authors.lastname: Martinez-Fong
mesh_terms: D000818:Animals; D001253:Astrocytes / Q000737:chemistry / Q000473:pathology; D001259:Ataxia / Q000235:genetics; D015415:Biomarkers; D001921:Brain / Q000473:pathology*; D003711:Demyelinating Diseases / Q000235:genetics* / Q000473:pathology; D018450:Disease Progression; D018871:Endoplasmic Reticulum, Smooth / Q000473:pathology; D004797:Enzyme-Linked Immunosorbent Assay; D020195:Epilepsy, Reflex / Q000235:genetics; D019084:Fluorescent Antibody Technique, Indirect; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D005911:Gliosis / Q000235:genetics* / Q000473:pathology; D006984:Hypertrophy; D008870:Microtubules / Q000473:pathology; D051381:Rats; D011922:Rats, Mutant Strains; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000235:genetics; D014202:Tremor / Q000235:genetics
chemical_list: D015415:Biomarkers; D005904:Glial Fibrillary Acidic Protein