title: Effects of dopamine antagonists in human eye accommodation.
abstract: The purpose of this study was to evaluate the effects of dopamine antagonists in accommodation of the human eye. The dopamine antagonist drugs used in this experiment include 0.5% metoclopramide and 0.25% droperidol. Eighteen healthy subjects were enrolled; they were randomly assigned, in double-masked fashion, to receive topical administration of a single drop of either 0.5% metoclopramide or 0.25% droperidol in one eye, with the fellow eye receiving isotonic saline as control. The accommodative abilities of both eyes were measured before instillation, and also at 3 and 6 hr after instillation of drugs, respectively. We studied the latency of reaction, the rate of accommodation, the average accommodative power, the rate of recovering and the total recovering time as the five parameters for evaluating the accommodative ability of each eye. The results showed that there were significant changes in two parameters: the rate of accommodation and rate of recovering, whereas there were no significant changes in the other three parameters: latency of accommodation, average power of accommodation and total recovering time. In conclusion, the dopamine antagonists may have some effects on the rate of accommodation but not the degree of accommodation. Further studies with higher concentrations of these dopamine antagonists on dose-response relationships are needed before exact drug efficacy can be drawn.
authors.affiliation: Department of Ophthalmology, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Republic of China.
authors.forename: L
authors.initials: L
authors.lastname: Yeung
authors.forename: P T
authors.initials: PT
authors.lastname: Hung
authors.forename: L L
authors.initials: LL
authors.lastname: Lin
authors.forename: C H
authors.initials: CH
authors.lastname: Yang
authors.forename: G C
authors.initials: GC
authors.lastname: Chiou
mesh_terms: D000065:Accommodation, Ocular / Q000187:drug effects* / Q000502:physiology; D000328:Adult; D002924:Ciliary Body / Q000502:physiology; D018492:Dopamine Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D004311:Double-Blind Method; D004329:Droperidol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage / Q000494:pharmacology*; D009130:Muscle, Smooth / Q000502:physiology; D009883:Ophthalmic Solutions
chemical_list: D018492:Dopamine Antagonists; D009883:Ophthalmic Solutions; D008787:Metoclopramide; D004329:Droperidol