[Effect of mifepristone on cell-cycle kinetics of human placental chorio-trophoblastic and decidual cell].
OBJECTIVE
To study the effects of mifepristone on cell-cycle kinetics of human placental chorio-trophoblastic and decidual cells.


METHODS
Flow-cytometry was introduced in the study of the mechanism of early pregnancy terminating drug, mifepristone. Twenty-three samples were obtained from normal pregnant women by surgical aspiration. Another 24 samples were obtained in women pretreated with 150 mg mifepristone 48 hours before operation.


RESULTS
The percentage of the cytotrophoblastic cells in G0 + G1 phases was much higher in the treatment group (P < 0.01), whereas it was much lower (P < 0.01) in G2 + M phases, and the proliferating index of cells was significantly decreased. Apart from the increasing of decidual cells in G2 + M phases (P < 0.05), there was no change in other phases.


CONCLUSIONS
Mifepristone may block the transformation of the cytotrophoblastic cells from G0, G1 phases to S phase, thus leading to the block of the proliferation of cells. Mifepristone has much more significant effects on the chorionic villi than on the decidua.
Zhou
X
X
Shenzhen Red Cross Hospital, Shenzhen 518029.
Wu
S
S
Zhang
L
L
D000021:Abortifacient Agents, Steroidal; D000028:Abortion, Induced / Q000379:methods; D000328:Adult; D002453:Cell Cycle / Q000187:drug effects; D002824:Chorionic Villi / Q000473:pathology*; D003656:Decidua / Q000166:cytology*; D005260:Female; D006801:Humans; D015735:Mifepristone; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D000021:Abortifacient Agents, Steroidal; D015735:Mifepristone