[Effects of ketamine and propofol on oxygen status and blood content of the brain in children].
Near infrared spectroscopy (NIRS) was used for noninvasive measurement of oxyhemoglobin (O2Hb) and total hemoglobin (tHb) in cerebral tissue and for evaluating local hemoglobin saturation with oxygen (rSO2) and cytochrome oxidase (Cytaa3) redox status in 68 children (6-14 years) during intravenous induction anesthesia with various anesthetics. Monoanesthesia with ketamine essentially increased the level of tHb and rSO2 and decreased the oxidized Cytaa3 fraction. Combined induction with ketamine and midazolame and propofol induction did not cause notable changes in the values of cerebral oxymetry.
Mikhel'son
V A
VA
Prokop'ev
G G
GG
Lazarev
V V
VV
D000293:Adolescent; D000367:Age Factors; D000778:Anesthetics, Dissociative / Q000494:pharmacology*; D018686:Anesthetics, Intravenous / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002648:Child; D003576:Electron Transport Complex IV / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007649:Ketamine / Q000494:pharmacology*; D008874:Midazolam / Q000494:pharmacology; D010092:Oximetry; D010100:Oxygen / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000378:metabolism; D015742:Propofol / Q000494:pharmacology*; D019265:Spectroscopy, Near-Infrared
D000778:Anesthetics, Dissociative; D018686:Anesthetics, Intravenous; D006454:Hemoglobins; D010108:Oxyhemoglobins; D007649:Ketamine; D003576:Electron Transport Complex IV; D008874:Midazolam; D010100:Oxygen; D015742:Propofol