Characterization of the hydroxypropylmethylcellulose-nicotinamide binary system.
The effect of hydroxypropylmethylcellulose (HPMC) on the thermal behaviour of nicotinamide was studied. Binary mixtures of nicotinamide and HPMC, composed of various weight fractions of HPMC (X(HPMC)), were heated, cooled and subsequently re-heated. HPMC dissolved in fused nicotinamide at 140 degrees C. The binary mixture at compositions 0<==X(HPMC)<==0.3 formed a film structure on cooling. At X(HPMC)>==0.4, the molten nicotinamide at 140 degrees C was saturated with HPMC. These heated mixtures did not form a homogeneous film by cooling to ambient temperature. At X(HPMC)<0.4, differential scanning calorimetry peaks originating from recrystallization and melting of nicotinamide were observed in the cooling and re-heating scans, respectively. These peaks became smaller with increase in X(HPMC) and disappeared at X(HPMC) approximately 0.4. Decrease in crystallinity with increase in X(HPMC) was confirmed by X-ray diffraction. The glass transition temperature of the cooled mixture (T(g)) increased with increase in X(HPMC). When the enthalpy of melting of nicotinamide and 1/T(g) were plotted against X(HPMC), inflections were observed at similar X(HPMC) values, 0.37-0.38. Dissolution of HPMC in molten nicotinamide was accompanied by hydrogen bond formation, which was confirmed by infrared studies.
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School of Pharmacy and Chemistry, James Parsons Building, Liverpool John Moores University, Byrom Street, L3 3AF, Liverpool, UK.
Ford
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JL
D000465:Algorithms; D002152:Calorimetry, Differential Scanning; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D007785:Lactose / Q000031:analogs & derivatives* / Q000737:chemistry*; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D009536:Niacinamide / Q000737:chemistry*; D010078:Oxazines; D013055:Spectrophotometry, Infrared; D017550:Spectroscopy, Fourier Transform Infrared; D013696:Temperature; D014961:X-Ray Diffraction
D010078:Oxazines; D009536:Niacinamide; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose