Pregnancy outcome in Hispanic patients with unexplained positive triple marker screening for Down syndrome.
OBJECTIVE
The objective of this study was to compare pregnancy outcomes in Hispanic patients with a positive serum triple marker screen for Down syndrome and normal fetal karyotype with Hispanic women who had a negative triple marker screen.


METHODS
This prospective investigation involved Hispanic gravidas who underwent maternal serum screening. A power analysis was performed to determine the sample size. Fifty women with false-positive screens for Down syndrome were matched with a control group of 100 women with a negative screen. Adverse pregnancy outcomes were compared between the two groups.


RESULTS
An adverse pregnancy outcome occurred in 14% of the study group and in 13% of controls. There were no statistically significant differences between the two groups in the incidence of preterm labor (p > 0.5), pre-eclampsia (p > 0.1), intrauterine growth restriction (p > 0.5), or fetal demise (p > 0.5).


CONCLUSIONS
Hispanic patients with unexplained positive triple marker screen for Down syndrome do not appear to be at increased risk for adverse pregnancy outcomes.
Naylor
C S
CS
Department of Obstetrics and Gynecology, University of California, Irvine Medical Center, Orange, USA. naylorc@cshs.org
Porto
M
M
Cohen
B
B
Garite
T J
TJ
D000328:Adult; D016022:Case-Control Studies; D004314:Down Syndrome / Q000097:blood / Q000175:diagnosis* / Q000235:genetics*; D005260:Female; D006630:Hispanic or Latino / Q000235:genetics*; D006801:Humans; D011247:Pregnancy; D011256:Pregnancy Outcome; D011296:Prenatal Diagnosis / Q000379:methods; D011446:Prospective Studies; D044465:White People / Q000235:genetics*