Cortical activation by tactile and painful stimuli in hemispherectomized patients.
Hemispherectomized patients are able to perceive tactile and painful stimuli on their nonparetic as well as paretic body halves. We have used functional MRI to study the cortical mechanisms underlying this preserved somatosensory capacity. Nonpainful brushing and painful heat were applied to the skin of the legs in four hemispherectomized patients and, for comparison, in four normal subjects. Cortical activation was studied with a 1.5 T scanner using a BOLD (blood oxygen level dependent) protocol. All patients rated both the brushing and the heat pain as almost equally intense on each leg and the ratings were similar to those in normals. Brushing on the nonparetic leg activated primary and secondary somatosensory cortices (S1 and S2) in all patients, similar to findings in normals. Brushing on the paretic leg activated S1 in two patients and S2 in one of these patients. Heat pain activated S2, insular cortex and anterior cingulate cortex to a similar degree for both legs, but the activation was weaker in the patients than in the normals. For the individual patient, there was generally no obvious correlation between cortical activation as studied with the BOLD technique and psychophysical performance. The findings from tactile stimulation of the nonparetic leg, that the activation was similar to the contralateral activation in normals, suggest that tactile information processing in the hemisphere contralateral to the stimulation is independent of the corpus callosum. In contrast, the pain activation for the nonparetic leg was weaker than in normals, suggesting that pain activation in the hemisphere contralateral to the stimulation is dependent on transcallosal information processing. The latter finding was corroborated by a subnormal capacity for pain localization on the nonparetic foot in two of the patients. The findings from stimulation of the paretic leg show that areas typically involved in the processing of tactile and painful stimuli can be activated by ipsilateral pathways directly from the periphery. The tactile-evoked ipsilateral S1 activation may be due to subcortical reorganization, since it was not observed in the normal subjects.
Olausson
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H
Department of Anaesthesia, Montreal Neurological Institute and Hospital, McGill University, Canada. olausson@physiol.gu.se
Ha
B
B
Duncan
G H
GH
Morin
C
C
Ptito
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A
Ptito
M
M
Marchand
S
S
Bushnell
M C
MC
D000328:Adult; D002540:Cerebral Cortex / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D002541:Cerebral Decortication; D003337:Corpus Callosum / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D004827:Epilepsy / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D007839:Functional Laterality; D006179:Gyrus Cinguli / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D006358:Hot Temperature; D006801:Humans; D007866:Leg / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009434:Neural Pathways / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology; D010100:Oxygen / Q000378:metabolism; D010146:Pain / Q000503:physiopathology*; D010147:Pain Measurement; D010291:Paresis / Q000503:physiopathology; D010812:Physical Stimulation; D014110:Touch / Q000502:physiology
D010100:Oxygen