title: The predictive value of gadolinium enhancement for long term disability in relapsing-remitting multiple sclerosis--preliminary results.
abstract: As short-term MRI studies are increasingly being used to monitor disease activity in multiple sclerosis (MS) it is vital to establish if short-term MRI activity is predictive of long term clinical outcome. We followed up after 5 years a group of 10 benign (relapsing-remitting MS with a disease duration > 10 years and EDSS < or = 3) and 10 early relapsing-remitting patients who previously had monthly serial MRI scans for 6 months. In the early relapsing-remitting group median EDSS at entry to the initial serial study was three and in the benign group 2.5. At 5-year follow up, five of these 20 patients had developed a definite deterioration in EDSS. The median number of new enhancing lesions detected originally in the group that had deteriorated was 11 (7-17) compared to 0 (0-5) new enhancing lesions, for those who had not deteriorated (P < 0.05). There was a trend towards a higher baseline T2 lesion load in the group with a definite change in EDSS but this was not significant This study suggests that short-term measurement of the number of gadolinium enhancing lesions may predict long term outcome in relapsing-remitting MS.
authors.affiliation: NMR Research Unit, Institute of Neurology, London, UK.
authors.forename: N A
authors.initials: NA
authors.lastname: Losseff
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
authors.forename: D
authors.initials: D
authors.lastname: Kidd
authors.forename: A J
authors.initials: AJ
authors.lastname: Thompson
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000473:pathology*; D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology; D003287:Contrast Media; D018450:Disease Progression; D005260:Female; D005500:Follow-Up Studies; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000473:pathology*; D010865:Pilot Projects; D011379:Prognosis
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA