Changes in peritoneal equilibration test values during long-term peritoneal dialysis in peritonitis-free children.
Little is known about the changes in peritoneal equilibration test (PET) values in children on long-term peritoneal dialysis (PD). In the present study, a PET was carried out every 6 months in 39 children (mean age 8.8 +/- 5.5 years) undergoing PD for 6 to 85 months (mean 36.9 +/- 23.1 months). Patients experiencing peritonitis were excluded. Both D/P creatinine (dialysate-to-plasma ratio of creatinine at 4 hours) and D/D0 glucose (ratio of dialysate glucose at 4 hours' dwell time to dialysis glucose at 0 dwell time) were measured 195 times in this series of patients. No remarkable change was found for D/P creatinine or D/D0 glucose during the first 24 months of PD but thereafter, D/P creatinine increased gradually and D/D0 glucose decreased gradually. Mean D/P creatinine increased significantly after the first 24 months of PD: from 0.66 +/- 0.12 during the first 24 months, to 0.70 +/- 0.09 after 25 months and more of PD (p = 0.0051). Mean D/D0 glucose decreased significantly after 24 months of PD: from 0.42 +/- 0.09 during the first 24 months, to 0.38 +/- 0.08 after 25 months and more of PD (p = 0.0015). The most significant change for both D/P creatinine and D/D0 glucose occurred after 24 months of PD. It seems reasonable to consider the mean PET values at 24 months of PD as the standard PET values.
Yoshino
A
A
Department of Pediatrics, Dokkyo University School of Medicine, Koshigaya Hospital, Saitama, Japan. a-yoshino@sam.hi-ho.ne.jp
Honda
M
M
Fukuda
M
M
Araki
Y
Y
Hataya
H
H
Sakazume
S
S
Tanaka
Y
Y
Kawamura
K
K
Murai
T
T
Kamiyama
Y
Y
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000378:metabolism; D015314:Dialysis Solutions / Q000737:chemistry; D005260:Female; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007223:Infant; D008297:Male; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000378:metabolism*; D013997:Time Factors
D015314:Dialysis Solutions; D003404:Creatinine; D005947:Glucose