title: [Anesthetics and the developing heart].
abstract: Effects of various anesthetics on the myocardium of developing heart are reviewed. Anesthetics suppress myocardial contractility in a fetus and newborn more intensively than in an adult. This is due to immature cell mechanisms regulating cardiomyocyte contractile activity and specific effect of the autonomic nervous system on the heart. It is obvious that the problem of interactions between anesthetics and developing cardiovascular system remains important because of constant introduction of new drugs with new cell and organ effects into practical anesthesiology.
authors.forename: P B
authors.initials: PB
authors.lastname: Tsyv'ian
authors.forename: I D
authors.initials: ID
authors.lastname: Medvinskiĭ
authors.forename: O G
authors.initials: OG
authors.lastname: Artem'eva
authors.forename: S V
authors.initials: SV
authors.lastname: Kinzhalova
mesh_terms: D000328:Adult; D000367:Age Factors; D000777:Anesthetics / Q000494:pharmacology*; D018685:Anesthetics, Inhalation / Q000494:pharmacology; D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D017704:Baroreflex / Q000187:drug effects; D002415:Cats; D003971:Diastole / Q000187:drug effects; D005260:Female; D005318:Fetal Heart / Q000187:drug effects*; D006321:Heart / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits; D013552:Swine; D013599:Systole / Q000187:drug effects
chemical_list: D000777:Anesthetics; D018685:Anesthetics, Inhalation; D000779:Anesthetics, Local