Hypoglycemia induced by secretion of high molecular weight insulin-like growth factor-II from a malignant solitary fibrous tumor of the pleura.
A 49-year-old woman with a malignant solitary fibrous tumor of the pleura presented with hypoglycemia. Most of the serum insulin-like growth factor II (IGF-II) existed as high molecular weight IGF-II. Furthermore, there were larger amounts of high molecular weight IGF-II found in the tumor cystic fluid than in the serum. After surgical resection of the tumor, high molecular weight IGF-II was not detected in the serum and the hypoglycemia resolved. Immunohistochemically, IGF-II was localized in the so-called Golgi area of the tumor cell. These findings suggest that hypoglycemia in this patient was caused by the high molecular weight IGF-II produced by the tumor.
Kishi
K
K
Division of Respiratory Diseases, Toranomon Hospital, Tokyo.
Homma
S
S
Tanimura
S
S
Matsushita
H
H
Nakata
K
K
D005260:Female; D005350:Fibroma / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006056:Golgi Apparatus / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology*; D007150:Immunohistochemistry; D007335:Insulin-Like Growth Factor II / Q000032:analysis / Q000378:metabolism*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000175:diagnosis* / Q000378:metabolism / Q000473:pathology / Q000601:surgery
D007335:Insulin-Like Growth Factor II