title: Beta-ketoacyl acyl carrier protein synthase III (FabH) is essential for fatty acid biosynthesis in Streptomyces coelicolor A3(2).
abstract: The Streptomyces coelicolor fab (fatty acid biosynthesis) gene cluster (fabD-fabH-acpP-fabF) is cotranscribed to produce a leaderless mRNA transcript. One of these genes, fabH, encodes a ketoacyl synthase III that is essential to and is proposed to be responsible for initiation of fatty acid biosynthesis in S. coelicolor.
authors.affiliation: John Innes Centre, Norwich Research Park, Colney, Norwich NR4 7UH, United Kingdom. revill@kosan.com
authors.forename: W P
authors.initials: WP
authors.lastname: Revill
authors.forename: M J
authors.initials: MJ
authors.lastname: Bibb
authors.forename: A K
authors.initials: AK
authors.lastname: Scheu
authors.forename: H J
authors.initials: HJ
authors.lastname: Kieser
authors.forename: D A
authors.initials: DA
authors.lastname: Hopwood
mesh_terms: D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / Q000235:genetics* / Q000378:metabolism*; D003470:Culture Media; D005227:Fatty Acids / Q000096:biosynthesis* / Q000235:genetics; D017353:Gene Deletion; D005798:Genes, Bacterial; D020043:Genes, Essential; D005810:Multigene Family; D013302:Streptomyces / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development
chemical_list: D003470:Culture Media; D005227:Fatty Acids; C077402:3-ketoacyl-acyl carrier protein synthase III; D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase