[Role of nitric oxide as a regulator of cell processes in the formation of multiple organ failure].
Main aspects of functional activity of nitric oxide (NO) are discussed. Physicochemical properties of NO, routes of its formation in man, and mechanism of its effects on physiological processes are described. In human body NO is formed as a result of activity of a specific enzyme, nitric oxide synthase. Three isoforms of the enzyme are known: neuronal, inducible, and endothelial. NO regulates vascular tone, cell adhesion, neurotransmission, bronchodilatation, and platelet aggregation. NO can protect and damage cells under different conditions. The effect of NO can be direct and mediated. Mechanisms of vasodilating effect of NO and of its effect on apoptosis are discussed. The role of NO in regulation of the functional activity of hepatocytes is described. Regulation of NO level in human organism is discussed.
Riabov
G A
GA
Azisov
Iu M
IuM
D000818:Animals; D017209:Apoptosis; D001980:Bronchi / Q000502:physiology; D002448:Cell Adhesion / Q000502:physiology; D002477:Cells / Q000166:cytology; D002478:Cells, Cultured; D003577:Cytochrome P-450 Enzyme System / Q000502:physiology; D005943:Gluconeogenesis; D006003:Glycogen / Q000502:physiology; D006706:Homeostasis; D006801:Humans; D008099:Liver / Q000166:cytology; D009102:Multiple Organ Failure / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000502:physiology; D010974:Platelet Aggregation / Q000502:physiology; D014176:Protein Biosynthesis; D051381:Rats; D013552:Swine; D009435:Synaptic Transmission / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D009569:Nitric Oxide; D006003:Glycogen; D003577:Cytochrome P-450 Enzyme System; D019001:Nitric Oxide Synthase