title: Dimeric L-dopa derivatives as potential prodrugs.
abstract: A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed.
authors.affiliation: Dipartimento di Scienze del Farmaco, Università G. D'Annunzio, Chieti, Italy. adistefano@unich.it
authors.forename: A
authors.initials: A
authors.lastname: Di Stefano
authors.forename: B
authors.initials: B
authors.lastname: Mosciatti
authors.forename: G M
authors.initials: GM
authors.lastname: Cingolani
authors.forename: G
authors.initials: G
authors.lastname: Giorgioni
authors.forename: M
authors.initials: M
authors.lastname: Ricciutelli
authors.forename: I
authors.initials: I
authors.lastname: Cacciatore
authors.forename: P
authors.initials: P
authors.lastname: Sozio
authors.forename: F
authors.initials: F
authors.lastname: Claudi
mesh_terms: D000818:Animals; D019281:Dimerization; D004355:Drug Stability; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007980:Levodopa / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D010949:Plasma / Q000378:metabolism; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D051381:Rats
chemical_list: D011355:Prodrugs; D007980:Levodopa