title: Derivation of dendritic cells from myeloid and lymphoid precursors.
abstract: The antigen presenting dendritic cells (DC) found in mouse and human lymphoid tissues are heterogeneous. Several subsets of mature DC have been described and these may correspond to distinct lineages. In this review, we present evidence obtained from a series of studies on the lineage origin of DC. This evidence points to the existence of at least three pathways for DC development, namely one from myeloid progenitors, a second from lymphoid progenitors and the third for Langerhans cells from precursors whose relationship to myeloid or lymphoid cell types is not yet clearly defined.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia. wu@wehi.edu.au
authors.forename: L
authors.initials: L
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Vandenabeele
authors.forename: K
authors.initials: K
authors.lastname: Georgopoulos
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D001773:Blood Cells / Q000166:cytology; D001854:Bone Marrow Cells / Q000166:cytology; D002454:Cell Differentiation; D019070:Cell Lineage; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D003713:Dendritic Cells / Q000145:classification / Q000166:cytology* / Q000276:immunology; D018507:Gene Expression Regulation, Developmental; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000166:cytology*; D051379:Mice; D018345:Mice, Knockout; D009000:Monocytes / Q000166:cytology; D022423:Myeloid Cells / Q000166:cytology*; D009928:Organ Specificity; D010586:Phagocytes / Q000166:cytology; D013234:Stem Cells / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
chemical_list: D014157:Transcription Factors; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor