title: [Ketamine pharmacokinetics and metabolism after bolus injection of X-ray contrast agents in roentgeno-endovascular interventions in children].
abstract: The study was carried out on 13 children (2-12 years) subjected to abdominal aortography. The children were divided into 2 groups. Changes in plasma concentrations of ketamine and its metabolism were evaluated during anesthesia after bolus injection of ionic highly osmolar and nonionic low-osmolar x-ray contrast agents (RCA). Injection of an RCA bolus was associated with a 2-fold more rapid drop of the anesthetic concentration in the blood, increase of renal clearance of ketamine and its metabolites; the osmotic effect of ionic highly osmolar and nonionic low-osmolar RCA on ketamine pharmacokinetics virtually did not differ.
authors.forename: V V
authors.initials: VV
authors.lastname: Lazarev
authors.forename: I E
authors.initials: IE
authors.lastname: Galibin
authors.forename: S A
authors.initials: SA
authors.lastname: Savchuk
authors.forename: B N
authors.initials: BN
authors.lastname: Izotov
authors.forename: A N
authors.initials: AN
authors.lastname: Vedenin
authors.forename: R P
authors.initials: RP
authors.lastname: Vasina
mesh_terms: D000367:Age Factors; D000778:Anesthetics, Dissociative / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D001027:Aortography; D002648:Child; D002675:Child, Preschool; D002845:Chromatography; D003287:Contrast Media / Q000008:administration & dosage*; D006801:Humans; D007649:Ketamine / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics; D013058:Mass Spectrometry
chemical_list: D000778:Anesthetics, Dissociative; D003287:Contrast Media; D007649:Ketamine