Alpha-tocopherol controls cell proliferation in the adult rat dentate gyrus.
The effect of alpha-tocopherol on cell proliferation and proliferated cell survival was investigated in the dentate gyrus of adult rats. Adult rats were supplemented with alpha-tocopherol, injected with 5-bromo-2'-deoxyuridine (BrdU), that is incorporated into DNA during the S-phase, and killed at different time after BrdU injection. The number of newborn cells decreased after alpha-tocopherol supplementation, confirming the hypothesis that alpha-tocopherol is able to depress cell proliferation in vivo. Most newborn cells die within few days; more newborn cells survive in alpha-tocopherol-treated rats, suggesting the hypothesis that alpha-tocopherol decreases cell death.
Cuppini
R
R
Institute of Physiological Sciences, Università degli Studi di Urbino loc. Crocicchia I-61029 (PS), Urbino, Italy. r.cuppini@uniurb.it
Ciaroni
S
S
Cecchini
T
T
Ambrogini
P
P
Ferri
P
P
Del Grande
P
P
Papa
S
S
D000367:Age Factors; D000818:Animals; D001973:Bromodeoxyuridine / Q000493:pharmacokinetics; D002452:Cell Count; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D002455:Cell Division / Q000187:drug effects* / Q000502:physiology; D018891:Dentate Gyrus / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D008297:Male; D009474:Neurons / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013234:Stem Cells / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology
D014810:Vitamin E; D001973:Bromodeoxyuridine