Molecular evaluation of the NUP98/RAP1GDS1 gene frequency in adults with T-acute lymphoblastic leukemia.
The NUP98/RAP1GDS1 (NRG) is a new fusion gene, originating from the t(4;11)(q21;p15) translocation, that characterizes a subset of T-cell acute lymphoblastic leukemia (T-ALL). In this study we analyzed 43 T-ALL patients for the expression of this new molecular marker using a reverse transcription-polymerase chain reaction (RT-PCR) system, which is more sensitive and specific than cytogenetics alone, confirming that NRG-positive ALLs are infrequent, accounting for approximately 5% of cases.
Cimino
G
G
Sprovieri
T
T
Rapanotti
M C
MC
Foà
R
R
Mecucci
C
C
Mandelli
F
F
D002880:Chromosomes, Human, Pair 11; D002894:Chromosomes, Human, Pair 4; D005787:Gene Frequency; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics*; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics*; D028861:Nuclear Pore Complex Proteins / Q000235:genetics*; D014178:Translocation, Genetic / Q000235:genetics*
D020662:Guanine Nucleotide Exchange Factors; D028861:Nuclear Pore Complex Proteins; C115955:RAP1GDS1 protein, human; C093350:nuclear pore complex protein 98