[Several hormonal indices during hemofiltration in patients with acute kidney failure].
OBJECTIVE
To study hormonal aspects of hemofiltration (HF) in acute renal failure (ARF).


METHODS
Hydrocortisone (HC), thyroxine (T4), triiodothyronine (T3), TSH, thyrocalcitonine (TC), PTH, insulin (I), C-peptide (CP), STH, beta-endorphine (BE) were examined for plasma content, elimination with filtrate, sifting rate, filtration clearance in 29 patients with oliguric ARF (18 males and 11 females) aged 12-62 years. 19 patients underwent intermittent HF (rate 145.2 +/- 9.2/27-260/ml/min, volume 1.02 +/- 0.20/0.45-1.43/). 10 patients received continuous HF (rate 25.9 +/- 2.3 l/day or 0.36 +/- 0.05/0.17-0.95/). The hormones were measured with radioimmunoassay. The results were processed with variate statistics using Student's criterium.


RESULTS
Oliguria was associated with high plasma levels of HC, PTH, TC, I, CP; normal levels of TSH and STH, low ones of T4, T3 and BE. Intermittent HF led to an increased plasma concentrations of HC, T4, I, CP, decreased one of PTH, while TC, TSH, STH and T3 remained unchanged. The filtration rate of the hormones was different. The elimination was greatest for HC, T4, T3, BE. Concentration of the former three in the filtrate surpassed that in blood plasma.


CONCLUSIONS
Besides intensive elimination of the hormones with low molecular mass (HC, T4, T3), HF causes elimination of appreciable quantities of BE, PTH, I, CT and, probably, other peptide hormones. Plasma levels of hormones did not reflect their elimination with filtrate.
Timokhov
V S
VS
Kazakov
I V
IV
Semenov
V N
VN
Bobkov
A I
AI
D058186:Acute Kidney Injury / Q000097:blood / Q000628:therapy*; D000293:Adolescent; D000328:Adult; D002096:C-Peptide / Q000097:blood; D002648:Child; D003627:Data Interpretation, Statistical; D005260:Female; D006440:Hemofiltration; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011863:Radioimmunoassay; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors; D001615:beta-Endorphin / Q000097:blood
D002096:C-Peptide; D006728:Hormones; D010281:Parathyroid Hormone; D013963:Thyroid Hormones; D001615:beta-Endorphin; D006854:Hydrocortisone