The NADPH oxidase of endothelial cells.
The best known NADPH oxidase is that of phagocytes-neutrophils and monocytes. In these cells, the enzyme manufactures large quantities of O2- and other reactive oxidants that are used for the purpose of killing invading microorganisms. Recent studies, however, have suggested that a number of other tissues contain NADPH oxidases. In contrast to the very vigorous production of oxidants by phagocytes, rates of oxidant production by these other cell types are quite low. Oxidant production by these cells is generally thought to serve a signaling function.
Babior
B M
BM
Department of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA. babior@scripps.edu
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D006801:Humans; D019255:NADPH Oxidases / Q000378:metabolism*; D010586:Phagocytes / Q000201:enzymology; D017382:Reactive Oxygen Species / Q000378:metabolism; D013481:Superoxides / Q000378:metabolism
D000924:Anticholesteremic Agents; D017382:Reactive Oxygen Species; D013481:Superoxides; D019255:NADPH Oxidases