[The state of antigen-dependent immunity system in children with chronic tonsillitis].
245 children aged 7-14 years with decompensated chronic tonsillitis were examined and treated in Anapa health resort. Before therapy the children had subnormal concentration of CD3+, CD4+/CD8+, elevated absolute and relative concentration of CD16+, low concentration of salivary IgA and SIgA combined with high serum IgM. The treatment brought a positive trend in the above indices, but CD16+, serum IgA and salivary SIgA remained higher than in controls. This may be explained by genetic predisposition of some children (primary defects of IgA and its secretory component synthesis), effects of autoimmune pathology, natural reaction to persistent viral infection.
Ponomarev
L E
LE
Khanferian
R A
RA
Borovikov
O V
OV
D000293:Adolescent; D015703:Antigens, CD / Q000276:immunology*; D002648:Child; D002908:Chronic Disease; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D014069:Tonsillitis / Q000276:immunology*
D015703:Antigens, CD; D007136:Immunoglobulins