title: Can initial distribution volume of glucose predict hypovolemic hypotension after radical surgery for esophageal cancer?
abstract: We recently reported that the initial distribution volume of glucose (IDVG) reliably measures the central extracellular fluid volume in the presence or absence of fluid gain or loss. We examined which variables, including IDVG, can predict subsequent hypovolemic hypotension produced by the continuous shift of the extracellular fluid from the central to the peripheral compartment early after radical surgery for esophageal cancer. IDVG and plasma volume were calculated after measuring cardiac index (CI), central venous pressure, and pulmonary artery wedge pressure immediately after admission to the intensive care unit. Intraoperative fluid balance and urine volume were also recorded. Postoperative hypovolemic hypotension was clinically defined as systolic blood pressure < 80 mm Hg responsive to IV fluid administration. Either IDVG < 105 mL/kg or CI < 3.4 L. min(-1). m(-2) was associated with subsequent hypovolemic hypotension (P = 0.002 for the former and P = 0.00 03 for the latter), while remaining variables were not. IDVG and CI were well correlated (r = 0.8 7, n = 25, P = 0.0001). Our results suggest that IDVG can help predict the subsequent hypovolemic hypotension early after radical surgery for esophageal cancer.
  
  
  CONCLUSIONS
  Routine cardiovascular variables immediately after major surgery cannot predict the subsequent hypovolemic hypotension produced by the shift of the extracellular fluid. Glucose dilution using glucose 5 g and a one-compartment model can predict it simply and rapidly.
authors.affiliation: Department of Anesthesiology, University of Hirosaki School of Medicine, 5-Zaifu-Cho, Hirosaki-Shi, 036-8562, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Ishihara
authors.forename: H
authors.initials: H
authors.lastname: Okawa
authors.forename: T
authors.initials: T
authors.lastname: Tsubo
authors.forename: A
authors.initials: A
authors.lastname: Matsuki
mesh_terms: D000328:Adult; D000368:Aged; D001825:Body Fluid Compartments; D002302:Cardiac Output; D004938:Esophageal Neoplasms / Q000601:surgery*; D005110:Extracellular Space / Q000502:physiology; D005260:Female; D018495:Fluid Shifts; D005440:Fluid Therapy; D005947:Glucose / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007022:Hypotension / Q000175:diagnosis* / Q000209:etiology* / Q000503:physiopathology; D020896:Hypovolemia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume; D011183:Postoperative Complications / Q000175:diagnosis*
chemical_list: D005947:Glucose