Treatment of androgenetic alopecia in females in reproductive age with topical estradiolbenzoate, prednisolon and salicylic acid.
BACKGROUND
Women generally regard their hair loss as socially unacceptable; it is a stressful condition that considerably undermines their self-image and can even be the basis for psychologic disorders.


OBJECTIVE
The aim of the present study was to evaluate the efficacy and safety of topical treatment of androgenetic alopecia (AGA) with estradiolbenzoate, prednisolon and salicylic acid solution (EPS) in females.


METHODS
An open trial with topical solution containing estradiolbenzoate, prednisolon and salicylic acid was performed in females suffering from AGA. Forty five female patients aged 18 to 42 years were enrolled in a 32-week trial. Forty two of the patients completed the trial. The mean nonvellus hair count taken within 1 cm2 in one and the same area was used to assess the treatment effect.


RESULTS
At the end of the trial 59.52% +/- 7.57% of the patients had no hair regrowth, 33.33% +/- %7.27% presented with minimal and 7.14% +/- 3.97% moderate hair growth. The mean count of nonvellus hair increased with 15.79 +/- 1.35. The treated patients showed no significant adverse effects.


CONCLUSIONS
Topical solution of estradiolbenzoate, prednisolon and salicylic acid is an efficacious and safety treatment of androgenetic alopecia in females.
Abadjieva
T I
TI
Higher Medical Institute, Department of Dermatology and Venerology, 15A Vassil Aprilov St., 4000 Plovdiv, Bulgaria.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000505:Alopecia / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005260:Female; D006197:Hair / Q000187:drug effects / Q000254:growth & development; D006801:Humans; D011239:Prednisolone / Q000627:therapeutic use*; D020156:Salicylic Acid / Q000627:therapeutic use*; D016896:Treatment Outcome
C074283:estradiol 3-benzoate; D004958:Estradiol; D011239:Prednisolone; D020156:Salicylic Acid