A locus affecting obesity in human chromosome region 10p12.
OBJECTIVE
Obesity is a complex trait influenced by multiple genes. We evaluated linkage in three regions of human chromosome 10 previously linked to obesity-related phenotypes.


METHODS
We conducted non-parametric linkage analysis of obesity-related phenotypes in cohorts of 170 European-American and 43 African-American families having extremely obese and normal weight subjects.


RESULTS
We found support for linkage of an obesity phenotype (BMI > or = 27 kg/m2) in both cohorts, as well as in a combined analysis (European-American cohort, Z = 1.90, p = 0.03; African-American cohort, Z = 2.25, p = 0.014; combined cohort, Z = 2.55, p = 0.005).


CONCLUSIONS
These results confirm previous reports of linkage in French and German families. The consistency of results across these four cohorts supports the localization of a quantitative trait locus influencing obesity to human chromosome region 10p12.
Price
R A
RA
Center for Neurobiology and Behavior, University of Pennsylvania, 415 Curie Blvd., CRB-135b, Philadelphia, PA 19104, USA.
Li
W D
WD
Bernstein
A
A
Crystal
A
A
Golding
E M
EM
Weisberg
S J
SJ
Zuckerman
W A
WA
D044383:Black People / Q000235:genetics*; D001824:Body Constitution; D015992:Body Mass Index; D001835:Body Weight; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D015331:Cohort Studies; D005060:Europe / Q000208:ethnology; D005819:Genetic Markers; D006801:Humans; D009765:Obesity / Q000235:genetics*; D010641:Phenotype; D015143:Philadelphia; D012016:Reference Values; D018709:Statistics, Nonparametric; D014481:United States; D044465:White People / Q000235:genetics*; D001741:Black or African American
D005819:Genetic Markers