title: Laser-induced interstitial thermotherapy of liver metastases in an interventional 0.5 Tesla MRI system: technique and first clinical experiences.
abstract: Laser-induced interstitial thermotherapy (LITT) surveyed by magnetic resonance imaging (MRI) has been shown to be effective in various applications. The laser treatment of colorectal liver metastases usually requires a separate device (e.g., ultrasound or CT) to position the laser applicator. In this study, we used an interventional 0.5 T MRI system, allowing both the navigation to the target tissue and on-line thermometry. Laser irradiation was performed using a near-infrared laser source combined with a cooled laser light guide. We treated 20 patients exhibiting a total of 58 colorectal liver metastases. Clinically relevant complications did not occur. No residual tumor was observed after laser irradiation in all metastases with a diameter below 2 cm. Metastases with a mean diameter between 2 and 3 cm demonstrated total necrosis in 71%, while in larger tumors this proportion decreased to 46% (diameter, 3-4 cm) and 30% (diameter, >4 cm), respectively. We conclude that LITT, guided by the employed interventional MRI system, is feasible and safe. The results suggest a more aggressive treatment, especially for larger metastases. J. Magn. Reson. Imaging 2001;13:729-737.
authors.affiliation: Department of Diagnostic Radiology, Klinikum Krefeld, Lutherplatz 40, D-47805 Krefeld, Germany.
authors.forename: V U
authors.initials: VU
authors.lastname: Fiedler
authors.forename: H J
authors.initials: HJ
authors.lastname: Schwarzmaier
authors.forename: F
authors.initials: F
authors.lastname: Eickmeyer
authors.forename: F P
authors.initials: FP
authors.lastname: Müller
authors.forename: C
authors.initials: C
authors.lastname: Schoepp
authors.forename: P R
authors.initials: PR
authors.lastname: Verreet
mesh_terms: D000368:Aged; D015179:Colorectal Neoplasms / Q000628:therapy*; D004869:Equipment Safety; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged