Suppression of lipopolysaccharide-induced liver injury by various types of tea and coffee in D-galactosamine-sensitized rats.
Extracts of various types of tea and coffee significantly suppressed lipopolysaccharide (LPS)-induced liver injury, as assessed by the plasma enzyme activities, in D-galactosamine-sensitized rats when administered orally once before injecting the drugs. There was a significant negative correlation between the caffeine levels of these extracts and liver injury. Authentic caffeine also had a hepatoprotective effect. These results suggest that caffeine-containing beverages generally suppress LPS-induced liver injury according to their caffeine content.
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Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University, Japan.
Noda
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Sugiyama
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D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers; D002110:Caffeine / Q000378:metabolism*; D003069:Coffee / Q000378:metabolism*; D005688:Galactosamine / Q000009:adverse effects*; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000293:injuries*; D008297:Male; D010936:Plant Extracts; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000378:metabolism*
D015415:Biomarkers; D003069:Coffee; D008070:Lipopolysaccharides; D010936:Plant Extracts; D013662:Tea; D002110:Caffeine; D005688:Galactosamine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase