title: BION system for distributed neural prosthetic interfaces.
abstract: We have developed the first in a planned series of neural prosthetic interfaces that allow multichannel systems to be assembled from single-channel micromodules called BIONs (BIOnic Neurons). Multiple BION implants can be injected directly into the sites requiring stimulating or sensing channels, where they receive power and digital commands by inductive coupling to an externally generated radio-frequency magnetic field. This article describes some of the novel technology required to achieve the required microminiaturization, hermeticity, power efficiency and clinical performance. The BION1 implants are now being used to electrically exercise paralyzed and weak muscles to prevent or reverse disuse atrophy. This modular, wireless approach to interfacing with the peripheral nervous system should facilitate the development of progressively more complex systems required to address a growing range of clinical applications, leading ultimately to synthesizing complete voluntary functions such as reach and grasp.
authors.affiliation: A.E. Mann Institute for Biomedical Engineering, University of Southern California, 1042 West 36th Place, Room B-12, Los Angeles, CA 90089-1112, USA. gloeb@usc.edu
authors.forename: G E
authors.initials: GE
authors.lastname: Loeb
authors.forename: R A
authors.initials: RA
authors.lastname: Peck
authors.forename: W H
authors.initials: WH
authors.lastname: Moore
authors.forename: K
authors.initials: K
authors.lastname: Hood
mesh_terms: D000818:Animals; D001698:Biomedical Engineering; D001701:Bionics / Q000295:instrumentation; D004599:Electric Stimulation Therapy / Q000295:instrumentation*; D005121:Extremities; D006801:Humans; D010243:Paralysis / Q000628:therapy; D019736:Prostheses and Implants; D011474:Prosthesis Design; D011846:Radio Waves; D014584:User-Computer Interface