[Measurement of vascular density in proliferative lesions of the thyroid gland].
In the present study vascular density was measure in histopathological slides of the simple goiter (15 cases) and of the same proliferative condition of the thyroid gland (113 cases) including adenoma (29 cases) and carcinoma (16 cases). Epithelial antibody CD31 and vWF identified vessels with the help of semiautomatic image analysis system. It has been shown that the highest values were typical for neoplastic tumors. However significant overlap has been shown. Statistically significant differences were very weakly seen between neoplasm's and thyroid hyperfunction. Also differences between carcinomas and adenomas were of low significance. Probably this is because of great heterogeneity of carcinomatosus neoplasms included in this study. Unexpectedly there were also no statistically significant differences between simple goiter, hyperplasia and thyroid hyperfunction.
Szot
W
W
Katedra Patofizjologii Collegium Medicum UJ ul. Czysta 18, 31-121 Kraków. mpszot@cyf-kr.edu.pl
Zaczek
M
M
Nowak
K
K
Dabroś
E
E
Gil
K
K
D000236:Adenoma / Q000098:blood supply / Q000473:pathology*; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D002277:Carcinoma / Q000098:blood supply / Q000473:pathology*; D005260:Female; D006042:Goiter / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D006965:Hyperplasia / Q000473:pathology; D007089:Image Enhancement / Q000379:methods; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000473:pathology; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000098:blood supply* / Q000737:chemistry / Q000473:pathology; D013964:Thyroid Neoplasms / Q000098:blood supply / Q000473:pathology*; D014841:von Willebrand Factor / Q000032:analysis
D000911:Antibodies, Monoclonal; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D014841:von Willebrand Factor