title: WD-repeat protein encoding genes among prokaryotes of the Streptomyces genus.
abstract: Southern hybridization with probes designed for detection of WD-repeats coding sequences gave positive results in 21 streptomycete strains indicating that WD-repeats encoding genes are massively spread among streptomycetes. One of them, the wdlA gene of Streptomyces lincolnensis, codes for a 971 amino acid protein with seven WD-repeats in its C-terminus, two transmembrane domains and an ATP/GTP binding site upstream of the WD-repeat region.
authors.affiliation: Laboratory of Physiology and Genetics of Actinomycetes, Institute of Microbiology, Academy of Sciences, Czech Republic, 142 20 Prague 4, Czechia. tichy@biomed.cas.cz
authors.forename: Z
authors.initials: Z
authors.lastname: Stoytcheva
authors.forename: B
authors.initials: B
authors.lastname: Joshi
authors.forename: J
authors.initials: J
authors.lastname: Spízek
authors.forename: P
authors.initials: P
authors.lastname: Tichý
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000595:Amino Acid Sequence; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D015139:Blotting, Southern; D003001:Cloning, Molecular; D015342:DNA Probes; D019204:GTP-Binding Proteins / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D020449:Repetitive Sequences, Amino Acid / Q000235:genetics* / Q000502:physiology; D016415:Sequence Alignment; D017422:Sequence Analysis, DNA; D013302:Streptomyces / Q000235:genetics* / Q000254:growth & development
chemical_list: D018528:ATP-Binding Cassette Transporters; D001426:Bacterial Proteins; D015342:DNA Probes; D008565:Membrane Proteins; C436007:wdlA protein, Streptomyces lincolnensis; D019204:GTP-Binding Proteins