Reactive and clonal thrombocytosis: proinflammatory and hematopoietic cytokines and acute phase proteins.
BACKGROUND
We quantitated proinflammatory and thrombopoietic cytokines in reactive thrombocytosis (RT) and clonal thrombocytosis (CT) to identify a cytokine profile that might aid in the distinction of these two disorders.


METHODS
Serum levels of cytokines relevant to platelet biology--interleukins 3, 6, 11, and 1beta; thrombopoietin; tumor necrosis factor alpha; and C-reactive protein (CRP)--were measured by enzyme-linked immunosorbent assay in healthy subjects and in patients with CT and RT.


RESULTS
Interleukin-6 and CRP levels were higher in RT patients than in controls or CT patients. Interleukin 1beta levels were higher in the RT group than in the CT and control groups.


CONCLUSIONS
In RT, IL-6, IL-1beta, and CRP levels are elevated. In both RT and CT, IL-11 is elevated, but thrombopoietin levels are not.
Araneda
M
M
Department of Internal Medicine, James H. Quillen VA Medical Center and James H. Quillen College of Medicine, East Tennessee State University, Johnson City 37614-0622, USA.
Krishnan
V
V
Hall
K
K
Kalbfleisch
J
J
Krishnaswamy
G
G
Krishnan
K
K
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002097:C-Reactive Protein / Q000378:metabolism*; D016022:Case-Control Studies; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods / Q000592:standards; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D017370:Interleukin-11 / Q000097:blood*; D007377:Interleukin-3 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012680:Sensitivity and Specificity; D013922:Thrombocytosis / Q000097:blood / Q000145:classification / Q000175:diagnosis* / Q000209:etiology* / Q000276:immunology; D013926:Thrombopoietin / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007375:Interleukin-1; D017370:Interleukin-11; D007377:Interleukin-3; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D013926:Thrombopoietin