title: A diagnostic and therapeutic approach to paragangliomas of the larynx.
abstract: BACKGROUND
  Differentiating paragangliomas from moderately differentiated neuroendocrine carcinoma in the larynx is a difficult management problem. As the biological behavior of these 2 entities is different, we developed an algorithm for the preoperative diagnosis and treatment of this disease.
  
  
  METHODS
  The sample case from which the algorithm was developed consisted of a 69-year-old man who was transferred to us after tracheostomy and an attempt at biopsy for airway obstruction secondary to a vascular mass. Biopsy resulted in substantial bleeding. Flexible laryngoscopy showed a vascular mass of the supraglottis. A computed tomographic scan showed 2 vascular masses at the carotid bifurcation and in the larynx. An arteriogram confirmed synchronous vascular tumors.
  
  
  RESULTS
  The arteriogram showed the superior thyroid artery to be the major feeder vessel to this mass, a situation commonly seen in paragangliomas but not other neuroendocrine tumors. The presence of synchronous lesions and a vascular mass based on the superior thyroid artery helped differentiate paraganglioma from the other neuroendocrine tumors. As the biological behavior of paragangliomas is relatively benign, we performed a conservative supraglottic laryngectomy and excision of the carotid body tumor. Histologic diagnosis and immunohistochemical analysis confirmed the diagnosis of paraganglioma.
  
  
  CONCLUSIONS
  The vascular nature of neuroendocrine tumors prevents preoperative pathological diagnosis. Radiologic features demonstrating a vascular mass with a dominant feeder vessel by the superior or inferior thyroid artery may help in the clinical diagnosis of paragangliomas of the larynx. Since paragangliomas are rarely malignant, a conservative surgical procedure should suffice.
authors.affiliation: Department of Otolaryngology/Head and Neck Surgery, LSU Health Science Center, Shreveport, LA 71130, USA.
authors.forename: K W
authors.initials: KW
authors.lastname: Sanders
authors.forename: F
authors.initials: F
authors.lastname: Abreo
authors.forename: E
authors.initials: E
authors.lastname: Rivera
authors.forename: F J
authors.initials: FJ
authors.lastname: Stucker
authors.forename: C A
authors.initials: CO
authors.lastname: Nathan
mesh_terms: D000368:Aged; D000465:Algorithms; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000628:therapy*; D007825:Laryngectomy; D008297:Male; D010236:Paraganglioma, Extra-Adrenal / Q000175:diagnosis* / Q000628:therapy*; D016896:Treatment Outcome