title: [Conversion to clinically definite multiple sclerosis after isolated spinal cord syndrome: value of brain and spinal MRI].
abstract: BACKGROUND
  Isolated spinal cord syndrome might be due to a first episode of multiple sclerosis. The aim of the study was to determine the clinical usefulness and paraclinical characteristics and of spinal and brain MR imaging predicting conversion to clinically definite multiple sclerosis (CDMS) in patients with an isolated spinal cord syndrome.
  
  
  METHODS
  We have evaluate thirty-eight patients with isolated spinal cord syndrome. A clinical protocol, lumbar puncture, evoked potential and brain-spinal cord MRI were performed.
  
  
  RESULTS
  Twenty two percent of the patients fulfilling brain MRI Paty criteria (p < 0.01), 54.5% Fazekas (p = 0.007) and 80% of patients fulfilling Barkhof criteria (p = 0.009) presented CDMS. The spinal MR imaging from CDMS patients was always abnormal, showing cervical and marginal location with a diameter < 2 cm.
  
  
  CONCLUSIONS
  Brain MRI is strongly predictive of the risk of developing CDMS and spinal cord MRI may increase the sensitivity to detect conversion to CDMS.
authors.affiliation: Unitat de Neuroimmunologia Clínica. Servei de Neurologia. Servei de Radiologia. Hospital Vall d'Hebron. Barcelona. esclerosismultiple@hgvehebron.es
authors.forename: I
authors.initials: I
authors.lastname: Pericot
authors.forename: M
authors.initials: M
authors.lastname: Tintoré
authors.forename: E
authors.initials: E
authors.lastname: Grivé
authors.forename: L
authors.initials: L
authors.lastname: Briev
authors.forename: A
authors.initials: A
authors.lastname: Rovira
authors.forename: X
authors.initials: X
authors.lastname: Montalbán
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis*; D013116:Spinal Cord / Q000473:pathology*