title: Ki-67: a proliferative marker that may predict pulmonary metastases and mortality of primary osteosarcoma.
abstract: Alterations in Ki-67 activity have been associated with tumor progression and poor outcome in cancer patients. This study was undertaken to identify the potential of this proliferative marker as a predictor of pulmonary metastases (PM) and mortality in osteosarcoma patients. In 38 patients with tissue available for immunohistochemical analysis, overexpression of Ki-67 was assessed. Chi-square and log rank tests were used to determine differences between proportions of the marker with PM and mortality and survival distributions respectively. P values equal or less than .05 were considered statistically significant. The median follow up of this case series was 28 months. Eighteen (47.4%) of 38 patients developed PM, and 17 (44%) overexpressed Ki-67. We found a high frequency of PM (15 of 17) among those cases that overexpressed Ki-67. This relationship was significant (P = .000006) when compared to the rest of the group. We also found a statistically significant correlation between patients with positive and negative Ki-67 scores and higher and lower mortality (P = .000962). These findings suggest that Ki-67 overexpression could be used as a prognostic molecular marker for the development of PM in osteosarcoma patients.
authors.affiliation: División of Investigación Clínica, Instituto Nacional de Cancerología, Mexico City, Mexico.
authors.forename: N A
authors.initials: NA
authors.lastname: Hernández-Rodríguez
authors.forename: E
authors.initials: E
authors.lastname: Correa
authors.forename: R
authors.initials: R
authors.lastname: Sotelo
authors.forename: A
authors.initials: A
authors.lastname: Contreras-Paredes
authors.forename: C
authors.initials: C
authors.lastname: Gomez-Ruiz
authors.forename: L
authors.initials: L
authors.lastname: Green
authors.forename: A
authors.initials: A
authors.lastname: Mohar
mesh_terms: D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001859:Bone Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D019394:Ki-67 Antigen / Q000378:metabolism*; D008175:Lung Neoplasms / Q000378:metabolism / Q000401:mortality / Q000556:secondary*; D008297:Male; D012516:Osteosarcoma / Q000378:metabolism / Q000401:mortality / Q000556:secondary*; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen