Baclofen inhibition of dorsal root-evoked inhibitory postsynaptic currents in substantia gelatinosa neurons of rat spinal cord slice.
We investigated the action of baclofen, an agonist for GABA(B) receptor, on the dorsal root-evoked inhibitory postsynaptic currents (IPSCs) in substantia gelatinosa (SG) neurons in the adult rat spinal cord slice. Most of the dorsal root-evoked IPSCs in SG were mediated by Adelta fibers. Baclofen (10 microM) reduced the amplitude of Adelta fiber-evoked glycine receptor-mediated IPSCs to 20.9+/-3.0% (n=13), and GABA(A) receptor-mediated IPSCs to 18.6+/-3.4% (n=12) of the controls, respectively. The results further suggest modulatory role of GABA(B) receptor in spinal dorsal horn.
Yang
K
K
Department of Anatomy and K.K. Leung Brain Research Centre, The Fourth Military Medical University, 710032, People's Republic of, Xi'an, China.
Feng
Y
Y
Li
Y
Y
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D004553:Electric Conductivity; D018755:GABA Agonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D013126:Spinal Nerve Roots / Q000187:drug effects / Q000502:physiology*; D013376:Substantia Gelatinosa / Q000166:cytology / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects*
D018755:GABA Agonists; D001418:Baclofen