[Morphologic study of renal carcinogenesis in rats induced by dimethylnitrosamine].
109 five-month-old albino non-inbred male rats received a single i.p. injection of dimethylnitrosamine (20 mg/kg b.w.) for selective induction of renal epithelial tumors. Forty controls were injected isotonic solution. The animals were autopsied 3-12 months later. Renal cell adenomas were found in 5 rats, mesenchymal renal--6. Renal tumor incidence increased during the experiment reaching 38.5% at month 12. No tumors were detected in controls. To summarize, our experiment failed to induce renal cell tumors only.
Zabezhinskiĭ
M A
MA
N.N. Petrov Research Institute of Oncology, Ministry of Health of the RF, St. Petersburg.
Arutiunov
A I
AI
D000236:Adenoma / Q000473:pathology; D000818:Animals; D002273:Carcinogens; D004128:Dimethylnitrosamine; D004195:Disease Models, Animal; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D008637:Mesenchymoma / Q000473:pathology; D051381:Rats
D002273:Carcinogens; D004128:Dimethylnitrosamine