Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata.
A known (1) and four new (2--5) lyso-PAF (platelet activating factor) derivatives were isolated from the sponge Spirastrella abata. Two of them are unprecedented in having a methoxy group at C-2'. The structures have been determined by combined spectroscopic methods. Their inhibitory effect on the biosynthesis of cholesterol and cytotoxicity against human solid tumor cell lines are reported.
Alam
N
N
College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
Bae
B H
BH
Hong
J
J
Lee
C O
CO
Shin
B A
BA
Im
K S
KS
Jung
J H
JH
D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera
C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor