Candidate gene polymorphisms in cardiovascular disease: a comparative study of frequencies between a French and an Italian population.
A multilocus assay was used to genotype up to 27 variable sites in 15 genes in French and Italian, presumed to be healthy populations (n=1480, n=162, respectively). These genes are involved in lipid metabolism (APOE, APOB, APOC3, CETP, LPL, PON), homocysteine metabolism (CBS, MTHFR), blood viscosity (Fibrinogen, FV), platelet aggregation (GpIIIa), leukocyte adhesion (SELE), and renin-angiotensin system (AT1R, ACE, AGT). Allele frequencies for all the markers were compared between the two populations. Five allele frequencies differed between the two European countries: APOB 71Ile (p < 0.001), SELE 98T (p < 0.001), SELE 128Arg (p < or = 0.01), APOE E4 (p < or = 0.01) and MTHFR 677T (p < or = 0.01), suggesting the existence of a north-south gradient in European allele frequencies. The other allele frequencies : APOC3 -482T, -455C, 1100T, 3175G, 3206G; LPL -93G, 9Asn, 291Ser; CETP 405Val; PON 192Arg; ACE Del; AGT 235Thr; AT1R 1166C; CBS 278Thr, GpIIIa P1A2; Fibrinogen -455A, FV 506Gln and SELE 554Phe, were similar between the two populations. They were also similar to those observed in other European countries.
Pallaud
C
C
INSERM U525, Centre de Médecine Préventive, Vandoeuvre-lès-Nancy, France.
Stranieri
C
C
Sass
C
C
Siest
G
G
Pignatti
F
F
Visvikis
S
S
D000483:Alleles; D001809:Blood Viscosity / Q000235:genetics; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics*; D015331:Cohort Studies; D005260:Female; D005602:France; D005787:Gene Frequency; D006710:Homocysteine / Q000235:genetics / Q000378:metabolism; D006801:Humans; D007558:Italy; D007962:Leukocytes / Q000502:physiology; D050356:Lipid Metabolism; D008055:Lipids / Q000235:genetics; D008297:Male; D010974:Platelet Aggregation / Q000235:genetics; D011110:Polymorphism, Genetic; D012084:Renin-Angiotensin System / Q000235:genetics
D008055:Lipids; D006710:Homocysteine