title: Interleukin-1beta converting enzyme/Caspase-1 (ICE/Caspase-1) and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients.
abstract: OBJECTIVE
  The aim of the study was to investigate the role of ICE/ Caspase-1 and soluble APO-1/Fas/CD 95 receptor in amyotrophic lateral sclerosis patients.
  
  
  METHODS
  The apoptosis parameters were measured by enzyme-linked immunosorbent assay (ELISA) in serum and cerebrospinal fluid from 25 amyotrophic lateral sclerosis and 15 control patients.
  
  
  RESULTS
  There has been shown a significant increase of ICE/Caspase-1 level in serum, and significant decrease of this parameter in cerebrospinal fluid from amyotrophic lateral sclerosis patients. Soluble APO-1/Fas/CD 95 level in amyotrophic lateral sclerosis patients did not differ from the control group. There was no significant correlation between clinical status, duration of amyotrophic lateral sclerosis, and levels of ICE/Caspase-1 and soluble APO-1/Fas/CD 95.
  
  
  CONCLUSIONS
  Our study suggests that ICE/Caspase-1 may play a role in neurodegeneration in ALS. Due to ethical difficulties we cannot include patients suffering from progressive neurological diseases, who are a more appropriate control group for the amyotrophic lateral sclerosis patients. Therefore we are limited in drawing conclusions from the research.
authors.affiliation: Department of Neurology, Lublin Medical School, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Iłzecka
authors.forename: Z
authors.initials: Z
authors.lastname: Stelmasiak
authors.forename: B
authors.initials: B
authors.lastname: Dobosz
mesh_terms: D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000503:physiopathology*; D017209:Apoptosis / Q000502:physiology; D020170:Caspase 1 / Q000032:analysis* / Q000502:physiology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019014:fas Receptor / Q000032:analysis* / Q000502:physiology*
chemical_list: D019014:fas Receptor; D020170:Caspase 1