The tripartite motif family identifies cell compartments.
A functional genomic approach, based on systematic data gathering, was used to characterize a family of proteins containing a tripartite motif (TRIM). A total of 37 TRIM genes/proteins were studied, 21 of which were novel. The results demonstrate that TRIM proteins share a common function: by means of homo-multimerization they identify specific cell compartments.
Reymond
A
A
Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milan, Italy.
Meroni
G
G
Fantozzi
A
A
Merla
G
G
Cairo
S
S
Luzi
L
L
Riganelli
D
D
Zanaria
E
E
Messali
S
S
Cainarca
S
S
Guffanti
A
A
Minucci
S
S
Pelicci
P G
PG
Ballabio
A
A
D020816:Amino Acid Motifs / Q000502:physiology*; D000818:Animals; D015152:Blotting, Northern; D002352:Carrier Proteins; D002451:Cell Compartmentation / Q000502:physiology*; D002460:Cell Line; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D016208:Databases, Factual; D004622:Embryo, Mammalian; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D016297:Mutagenesis, Site-Directed; D009419:Nerve Tissue Proteins; D009928:Organ Specificity; D011485:Protein Binding / Q000502:physiology; D017434:Protein Structure, Tertiary / Q000502:physiology; D011506:Proteins / Q000502:physiology*; D017386:Sequence Homology, Amino Acid; D013347:Subcellular Fractions / Q000378:metabolism; D020798:Two-Hybrid System Techniques; D044767:Ubiquitin-Protein Ligases
D002352:Carrier Proteins; D009419:Nerve Tissue Proteins; D011506:Proteins; C485964:Trim8 protein, mouse; D044767:Ubiquitin-Protein Ligases