Sterol regulatory element-binding protein-1 as a dominant transcription factor for gene regulation of lipogenic enzymes in the liver.
Sterol regulatory element-binding proteins (SREBPs) are basic helix-loop-helix (bHLH) type transcription factors that control expression of genes involved in biosynthesis of cholesterol and fatty acids. Dietary studies with normal, transgenic, and knockout mice have established SREBP-1 as a dominant transcription factor regulating gene expression of lipogenic enzyme in the liver. Polyunsaturated fatty acids inhibit hepatic lipogenic enzymes through suppressing SREBP-1. Whereas SREBP-2 exerts sterol regulation through cleavage of the membrane-bound precursor protein to liberate the active nuclear form into the nucleus, SREBP-1 controls lipogenic enzymes by self-regulating its own transcription level. Promoter analysis of the SREBP-1 gene will be important to clarify the mechanism of nutritional regulation of lipogenic genes.
Shimano
H
H
Department of Internal Medicine, Institute of Clinical Medicine, 1-1-1 Tennodai, Tsukuba, Ibaraki, 305-8575 Japan. shimano-tky@umin.ac.jp
D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis / Q000235:genetics; D015971:Gene Expression Regulation, Enzymologic / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors / Q000235:genetics*
D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D005231:Fatty Acids, Unsaturated; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors