title: A comparison of renal phosphorus regulation in thermally injured and multiple trauma patients receiving specialized nutrition support.
abstract: To compare phosphorus intake and renal phosphorus regulation between thermally injured patients and multiple trauma patients, 40 consecutive critically ill patients, 20 with thermal injury and 20 with multiple trauma, who required enteral tube feeding were evaluated. Phosphorus intakes were recorded for 14 days from the initiation of tube feeding which was started 1 to 3 days postinjury. Serum for determination of phosphorus concentrations was collected at days 1, 3, 7, and 14 of the study period. A 24-hour urine collection was obtained during the first and second weeks of nutrition support for urinary phosphorus excretion, fractional excretion of phosphorus, renal threshold phosphate concentration, and phosphorus clearance. Average total daily phosphorus intake during the 14-day study for thermally injured patients and multiple trauma patients was 0.99+/-0.26 mmol/kg/d vs 0.58+/-0.21 mmol/kg/d, respectively, p < .001. Serum phosphorus concentration on the third day of observation was significantly lower in the thermally injured group than those with multiple trauma (1.9+/-0.8 mg/dL vs 3.0+/-0.8 mg/dL, p < or = .01). A trend toward hypophosphatemia in the thermally injured group persisted by the seventh day of feeding (2.7+/-1.2 mg/dL vs 3.3+/-0.6 mg/dL, p < or = .04). Differences in urinary phosphorus excretion was not statistically significant between the thermally injured and multiple trauma groups (271+/-213 mg/d vs 171+/-181 mg/d for week 1, and 320+/-289 mg/d vs 258+/-184 mg/d for week 2, respectively). Urinary phosphorus clearance, fractional excretion of phosphorus, or renal threshold phosphate concentrations were also not significantly different between thermally injured and multiple trauma patients. During nutrition support, serum phosphorus concentrations are lower in thermally injured patients compared with multiple trauma patients despite receiving a significantly greater intake of phosphorus. Renal phosphorus regulation does not significantly contribute to the profound hypophosphatemia observed in thermally injured patients when compared with multiple trauma patients during nutrition support.
authors.affiliation: Department of Clinical Pharmacy, The University of Tennessee Health Science Center, Memphis 38163, USA.
authors.forename: R N
authors.initials: RN
authors.lastname: Dickerson
authors.forename: J M
authors.initials: JM
authors.lastname: Gervasio
authors.forename: J J
authors.initials: JJ
authors.lastname: Sherman
authors.forename: K A
authors.initials: KA
authors.lastname: Kudsk
authors.forename: W L
authors.initials: WL
authors.lastname: Hickerson
authors.forename: R O
authors.initials: RO
authors.lastname: Brown
mesh_terms: D000328:Adult; D002056:Burns / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D004750:Enteral Nutrition / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017674:Hypophosphatemia / Q000209:etiology* / Q000517:prevention & control; D007668:Kidney / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000150:complications / Q000378:metabolism / Q000628:therapy*; D010758:Phosphorus / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D011446:Prospective Studies
chemical_list: D010758:Phosphorus