Antihypertensive effects of Dorstenia psilurus extract in fructose-fed hyperinsulinemic, hypertensive rats.
We examined the effect of methanol/methylene chloride extract of Dorstenia psilurus given by gastric intubation on systolic blood pressure, plasma glucose, insulin, cholesterol, triglycerides and creatinine in rats with fructose-induced hypertension. Male Wistar rats in groups of 6 animals each were fed fructose-rich diets or standard chow for 3 weeks and treated with 100 mg/kg/day or 200 mg/kg/day of plant extract or vehicle for 3 subsequent weeks. Systolic blood pressure was measured every three days using the indirect tail cuff method. Systolic blood pressure was higher in fructose-fed rats (142+/-2 mm Hg, p < 0.01) compared with the controls (112+/-2 mm Hg), and was lower in Dorstenia psilurus-treated groups (127+/-2 and 119+/-1 mm Hg for the dose of 100 and 200 mg/kg, respectively) compared with the fructose-fed rats. Plasma insulin, cholesterol and triglycerides were higher on the fructose-rich diet compared with the controls. Plasma insulin and cholesterol were lower in the Dorstenia psilurus-treated groups. These results suggest that, Dorstenia psilurus treatment could prevent and reverse high blood pressure induced by a diet rich in fructose probably by improvement of plasma insulin levels. The plant extract might prove useful in the treatment and/or prevention of hypertension.
Dimo
T
T
Department of Animal Biology and Physiology, Faculty of Sciences, University of Yaounde I, Cameroon. tdimo@uycdc.uninet.cm
Rakotonirina
A
A
Tan
P V
PV
Dongo
E
E
Dongmo
A B
AB
Kamtchouing
P
P
Azay
J
J
Abegaz
B M
BM
Cros
G
G
Ngadjui
T B
TB
D000349:Africa; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D003404:Creatinine / Q000378:metabolism; D004195:Disease Models, Animal; D005632:Fructose / Q000008:administration & dosage; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control*; D015228:Hypertriglyceridemia / Q000378:metabolism; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000502:physiology; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology*; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales; D014280:Triglycerides / Q000378:metabolism
D000959:Antihypertensive Agents; D001786:Blood Glucose; D007328:Insulin; D010936:Plant Extracts; D014280:Triglycerides; D005632:Fructose; D002784:Cholesterol; D003404:Creatinine; D009543:Nifedipine