Biologically active substituted benzodiazepines and their effect on cardiovascular and central nervous system.
Some substituted 1,5-benzodiazepine derivatives (including a spirocyclopentane moiety) were synthesized (Table I) and evaluated for their hypotensive and CNS activities respectively. The compounds which showed promising cardiovascular activity also exhibited marked anti-depressant action (Table II,III,IV). All the compounds showed higher ALD50 value.
Shukla
S
S
Department of Pharmacology and Therapeutics, K.G. Medical College, Lucknow, India.
Misra
U
U
Bhalla
M
M
Mukerjee
D
D
Saxena
A K
AK
Sinha
J N
JN
Shanker
K
K
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001569:Benzodiazepines / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D008297:Male; D051379:Mice
D001569:Benzodiazepines