Asthma from diisocyanates is not mediated through a Type IV, patch-test-positive mechanism.
The mechanism of occupational asthma from diisocyanates (DI)(1-10)(Fig. 1) is not fully known; only about 10%-30% of such patients have specific IgE antibodies to DI (3, 11, 12). A T-cell mediated response has been considered to be involved in DI asthma (13) and we therefore wondered whether patch testing might be of any help in its diagnosis.
Kanerva
L
L
Finnish Institute of Occupational Health, Topeliuksenkatu 41 aA, FIN-00250 Helsinki, Finland.
Estlander
T
T
Jolanki
R
R
Keskinen
H
H
D000328:Adult; D000485:Allergens / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced*; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology; D005260:Female; D006229:Hand Dermatoses / Q000139:chemically induced; D006801:Humans; D017953:Isocyanates / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010150:Paint / Q000009:adverse effects; D010328:Patch Tests; D014051:Toluene 2,4-Diisocyanate / Q000009:adverse effects*; D001559:Benzhydryl Compounds
D000485:Allergens; D017953:Isocyanates; D014051:Toluene 2,4-Diisocyanate; C005969:4,4'-diphenylmethane diisocyanate; D001559:Benzhydryl Compounds