title: Oncogenic osteomalacia associated with mesenchymal tumour detected by indium-111 octreotide scintigraphy.
abstract: In a 40-year-old man who had suffered from vague and generalized bone pains for 7 years due to oncogenic osteomalacia, the causative tumour was finally detected by Indium-111 octreotide scintigraphy. Some characteristics of the tumour associated with oncogenic osteomalacia, such as its size, growth rate, location and origin, often make the diagnosis difficult. However, the recent discovery of somatostatin receptors in mesenchymal tumours, which are the most common cause of oncogenic osteomalacia, has raised the possibility of early detection of this devastating disorder. Here, we report that radiolabelled octreotide scintigraphy has a potential role as a diagnostic tool in oncogenic osteomalacia. However, the exact role of somatostatin receptors in tumours associated with oncogenic osteomalacia still remains elusive.
authors.affiliation: Department of Internal Medicine, College of Medicine, Yonsei University, Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Rhee
authors.forename: J D
authors.initials: JD
authors.lastname: Lee
authors.forename: K H
authors.initials: KH
authors.lastname: Shin
authors.forename: H C
authors.initials: HC
authors.lastname: Lee
authors.forename: K B
authors.initials: KB
authors.lastname: Huh
authors.forename: S K
authors.initials: SK
authors.lastname: Lim
mesh_terms: D000328:Adult; D019644:Arthroplasty, Replacement, Hip; D015415:Biomarkers / Q000097:blood; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000601:surgery; D006801:Humans; D007205:Indium Radioisotopes / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D008637:Mesenchymoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000601:surgery; D015282:Octreotide / Q000378:metabolism; D010018:Osteomalacia / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000601:surgery; D010710:Phosphates / Q000097:blood; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000378:metabolism
chemical_list: D015415:Biomarkers; D007205:Indium Radioisotopes; D010710:Phosphates; D017481:Receptors, Somatostatin; D015282:Octreotide