Change in tissue kallikrein level in nasal wash after the administration of oxatomide in patients with nasal allergy.
The tissue kallikrein level in the nasal wash was measured before and after 4-week administration of oxatomide (30 mg per day) in 9 patients with perennial allergy. It was found that tissue kallikrein level in the nasal wash obtained following provocation tests significantly decreased from 6.05 +/- 4.43 (10(-10) mol/hour/L) to 1.84 +/- 0.93 (10(-10) mol/hour/L) after the administration of oxatomide. Improvement in subjective symptoms was also observed in all patients after the administration. These results would indicate that kinin in the system is actively involved in the pathogenesis of nasal allergy.
Nishiyama
K
K
Section of Otorhinolaryngology, Yokohama National Hospital, Kanagawa, Japan.
Yao
K
K
Iguci
Y
Y
Yamamoto
K
K
Suzuki
T
T
Sato
K
K
Okamoto
M
M
Majima
M
M
D001826:Body Fluids / Q000737:chemistry*; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000503:physiopathology*; D016234:Kallikrein-Kinin System / Q000502:physiology*; D007610:Kallikreins / Q000032:analysis*; D010879:Piperazines / Q000494:pharmacology*; D012220:Rhinitis / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology*
D006634:Histamine H1 Antagonists; D010879:Piperazines; D007610:Kallikreins; C015408:oxatomide