Epigenetic analysis of kinetochore assembly on variant human centromeres.
Human centromere formation involves the assembly of the mitotic kinetochore onto chromosomal locations that contain the interphase prekinetochore. Immunofluorescent analysis of two functionally converse human centromere variants, neocentromeres and inactive centromeres, has been used to evaluate the functional significance of over 24 CENTROMERE proteins, providing important insight into the epigenetics of centromere formation and kinetochore assembly.
Warburton
P E
PE
Dept of Human Genetics, PO Box 1498, Mount Sinai School of Medicine, East Building 14-52A, 1425 Madison Ave, New York, NY 10029, USA. peter.warburton@mssm.edu
D002503:Centromere / Q000235:genetics*; D002868:Chromosomal Proteins, Non-Histone / Q000235:genetics / Q000502:physiology; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D005455:Fluorescent Antibody Technique; D006801:Humans; D018386:Kinetochores; D046911:Macromolecular Substances
D002868:Chromosomal Proteins, Non-Histone; D046911:Macromolecular Substances