title: Orthostatic hypotension in elderly persons during passive standing: a comparison with young persons.
abstract: BACKGROUND
  The present study was aimed at clarifying the mechanism of orthostatic hypotension (OH) that occurs in elderly persons and at investigating assisting methods to prevent OH by evaluating changes in autonomic nervous system (ANS) activity and cerebral circulation of elderly persons when engaged in passive standing.
  
  
  METHODS
  Eight elderly volunteers and 9 young volunteers gave informed consent to participate in the study. Two experimental conditions were established: (i) "active standing," in which the subjects stood on their own with guidance from an assistant, and (ii) "passive standing," in which the subjects were placed in a standing position completely by an assistant. ANS was determined before and after standing by measuring the heart rate variability. The reaction of the ANS was evaluated on the basis of low-frequency power (LF: 0.05--0.15 Hz) and high-frequency power (HF: 0.15--0.4 Hz), which were separated from the R-R interval data by power spectral analysis using the fast Fourier transformation. Cerebral perfusion was measured over the right frontal region using a near-infrared spectroscopy cerebral oxygen monitor.
  
  
  RESULTS
  The main findings were: (i) Transient decreases in blood pressure occurred immediately after standing in both the young and elderly subjects. (ii) The LF:HF ratio increased significantly ( p <.05) immediately after active standing in the young subjects, whereas this ratio increased in the elderly subjects after some delay. (iii) The LF:HF ratio increased significantly ( p <.01) immediately after passive standing in the young subjects, whereas this ratio decreased significantly ( p <.05) in the elderly subjects. (iv) In the elderly subjects, the total hemoglobin (HbT) and oxyhemoglobin showed the greatest decrease during the 15-second period after standing. The maximum changes in the HbT with passive standing differed significantly ( p <.01) from those observed during active standing.
  
  
  CONCLUSIONS
  Our findings emphasize the need to devise bioengineered means that allow elderly persons to exert themselves, to maintain or improve muscle contractility and ANS function, while providing minimum assistance for standing.
authors.affiliation: College of Nursing Art and Science Hyogo, Akashi, Japan. takayasu_kawaguchi@cnas-hyogo.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kawaguchi
authors.forename: O
authors.initials: O
authors.lastname: Uyama
authors.forename: M
authors.initials: M
authors.lastname: Konishi
authors.forename: T
authors.initials: T
authors.lastname: Nishiyama
authors.forename: T
authors.initials: T
authors.lastname: Iida
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D001341:Autonomic Nervous System / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007024:Hypotension, Orthostatic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010108:Oxyhemoglobins / Q000032:analysis; D011187:Posture / Q000502:physiology*
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins