title: Event-related potentials to threat-related faces in schizophrenia.
abstract: Specialised network disturbances such as abnormalities in processing faces, may be associated with functional disturbances of interpersonal communication in schizophrenia. This study focused on the temporal dimension, investigating facial processing deficits in patients with schizophrenia (and non-patient controls) in a passive event-related potential (ERP) paradigm. ERPs invoked to an angry and neutral face stimulus were recorded in 27 patients with schizophrenia and 27 age and sex matched normal controls. Patients with schizophrenia showed a significant generalised delay, and diminished P200 amplitude (primarily frontal) for both stimuli-with more widespread regions of disturbance associated with the angry face. Normal controls, on the other hand, showed relatively reduced posterior P200 amplitude for angry compared to neutral faces, and a lateralised pattern of engagement in response to both stimuli. These findings indicate suboptimal processing of neutral faces in patients with schizophrenia, further exacerbated for affect laden angry faces.
authors.affiliation: The Brain Dynamics Centre, Department of Psychological Medicine, Westmead Hospital, Westmead NSW 2145, Australia. khorley@hotmail.com
authors.forename: K
authors.initials: K
authors.lastname: Horley
authors.forename: C
authors.initials: C
authors.lastname: Gonsalvez
authors.forename: L
authors.initials: L
authors.lastname: Williams
authors.forename: I
authors.initials: I
authors.lastname: Lazzaro
authors.forename: H
authors.initials: H
authors.lastname: Bahramali
authors.forename: E
authors.initials: E
authors.lastname: Gordon
mesh_terms: D000328:Adult; D000339:Affect; D001921:Brain / Q000503:physiopathology*; D005071:Evoked Potentials / Q000502:physiology*; D005149:Facial Expression; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D011930:Reaction Time; D012559:Schizophrenia / Q000503:physiopathology*; D013702:Temporal Lobe / Q000503:physiopathology*; D014796:Visual Perception / Q000502:physiology*