A randomised, double masked, clinical trial of high dose vitamin A and vitamin E supplementation after photorefractive keratectomy.
OBJECTIVE
To evaluate the effect of a high dose vitamin A and E supplementation on corneal re-epithelialisation time, visual acuity and haze following photorefractive keratectomy (PRK).


METHODS
Two groups of 20 patients who underwent myopic PRK were supplemented with either 25 000 IU retinol palmitate and 230 mg alpha tocopheryl nicotinate or a placebo. Clinical outcomes were evaluated up to 360 days.


RESULTS
In the vitamin treated group, re-epithelialisation time was significantly faster (p = 0.029) and haze incidence was reduced (p = 0.035), especially for high myopic corrections (p = 0.043). This group also reported a significantly better uncorrected visual acuity (p = 0.043).


CONCLUSIONS
High dose vitamin A and E oral supplementation may accelerate re-epithelialisation time and may reduce corneal haze formation after PRK.
Vetrugno
M
M
Eye Institute, Department of Ophthalmology--Otorhinolaryngology, University of Bari, Italy. m.vetrugno@oftalmo.uniba.it
Maino
A
A
Cardia
G
G
Quaranta
G M
GM
Cardia
L
L
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D004311:Double-Blind Method; D019573:Epithelium, Corneal / Q000187:drug effects; D006801:Humans; D054018:Lasers, Excimer; D009216:Myopia / Q000628:therapy*; D009883:Ophthalmic Solutions / Q000627:therapeutic use; D018903:Photorefractive Keratectomy / Q000379:methods*; D055502:Secondary Prevention; D013256:Steroids; D013997:Time Factors; D016896:Treatment Outcome; D014792:Visual Acuity / Q000187:drug effects; D014801:Vitamin A / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D009883:Ophthalmic Solutions; D013256:Steroids; D014801:Vitamin A; D014810:Vitamin E