Increased frequency of alleles associated with elevated tumor necrosis factor-alpha levels in children with Kawasaki disease.
Genetic polymorphisms influence the magnitude of the cytokine response after an inflammatory stimulus. To determine whether such polymorphisms might play a role in Kawasaki disease (KD), we analyzed white and Japanese children with KD and control populations for two polymorphic loci in which the A allele is associated with high tumor necrosis factor-alpha secretion. The lymphotoxin-alpha+250 A/A genotype was overrepresented among white children with KD compared with controls (0.59 versus 0.36; p = 0.013). The tumor necrosis factor-alpha-308 A/G genotype was overrepresented among whites with KD who had coronary artery abnormalities compared with those with normal echocardiograms (0.36 versus 0.09; p = 0.044). No significant difference was seen at either locus between Japanese children with KD and Japanese controls. The increased frequency of the high secretor alleles in white children with KD suggests that these loci may be related to susceptibility to KD and to outcome after disease.
Quasney
M W
MW
Division of Critical Care, Department of Pediatrics, Crippled Children's Foundation Research Center, LeBonheur Children's Medical Center, University of Tennessee, Memphis, Tennessee 38103, USA. mquasney@utmem.edu
Bronstein
D E
DE
Cantor
R M
RM
Zhang
Q
Q
Stroupe
C
C
Shike
H
H
Bastian
J F
JF
Matsubara
T
T
Fujiwara
M
M
Akimoto
K
K
Newburger
J W
JW
Burns
J C
JC
D000483:Alleles; D001483:Base Sequence; D016022:Case-Control Studies; D002648:Child; D003330:Coronary Vessel Anomalies; D017931:DNA Primers; D005006:Ethnicity / Q000235:genetics; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage; D009080:Mucocutaneous Lymph Node Syndrome / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D017931:DNA Primers; D016756:Immunoglobulins, Intravenous; D014409:Tumor Necrosis Factor-alpha