Transcription factors that regulate growth and differentiation of myeloid cells.
Recently much progress has been made in our understanding of how myeloid progenitor cells undergo commitment and become mature granulocytes or monocytes/macrophages. Studies of normal and leukemic myeloid cells as well as those of cells derived from mice with targeted disruption showed that a series of transcription factors play a major role in both commitment and maturation of myeloid cells. This is primarily because these transcription factors direct an ordered pattern of gene expression according to a well-defined developmental program. PU.1, an Ets family member, is one of the master transcription factors identified to regulate development of both granulocytes and monocytes/macrophages. Further, C/EBPalpha and C/EBPvarepsilon of the bZip family have important roles in directing granulocytic maturation. A number of additional transcription factors such as AML1, RARalpha, MZF-1, Hox and STAT families of transcription factors, Egr-1 and c-myb etc are shown to play roles in myeloid cell differentiation. Our laboratory has recently obtained evidence that ICSBP, a member of the IRF family, is involved in lineage commitment during myeloid cell differentiation and stimulates maturation of functional macrophages. Future elucidation of pathways and networks through which these transcription factors act in various stages of development would provide a more definitive picture of myeloid cell commitment and maturation.
Nagamura-Inoue
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Laboratory of Molecular Growth Regulation National Institute of Child Health and Human Development National Institutes of Health, Bethesda, MD 20892-2753, USA.
Tamura
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Ozato
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D000818:Animals; D022763:CCAAT-Enhancer-Binding Protein-alpha / Q000502:physiology; D002454:Cell Differentiation / Q000235:genetics; D002455:Cell Division / Q000235:genetics; D019070:Cell Lineage; D002478:Cells, Cultured; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D018507:Gene Expression Regulation, Developmental; D015973:Gene Expression Regulation, Leukemic; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology; D006801:Humans; D050835:Interferon Regulatory Factors; D016350:Leucine Zippers / Q000502:physiology; D007951:Leukemia, Myeloid / Q000473:pathology; D051379:Mice; D018345:Mice, Knockout; D008957:Models, Genetic; D005810:Multigene Family; D022423:Myeloid Cells / Q000166:cytology* / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D014411:Neoplastic Stem Cells / Q000166:cytology; D015514:Oncogene Proteins, Fusion / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D012097:Repressor Proteins / Q000235:genetics / Q000502:physiology; D013234:Stem Cells / Q000166:cytology; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000145:classification / Q000235:genetics / Q000502:physiology*; D016335:Zinc Fingers / Q000235:genetics / Q000502:physiology; D000099185:Interferon Regulatory Factor-8; D000099232:Proto-Oncogene Protein Spi-1
D022763:CCAAT-Enhancer-Binding Protein-alpha; D050676:Core Binding Factor Alpha 2 Subunit; D004268:DNA-Binding Proteins; D016298:Hematopoietic Cell Growth Factors; D050835:Interferon Regulatory Factors; D009363:Neoplasm Proteins; D015514:Oncogene Proteins, Fusion; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000099185:Interferon Regulatory Factor-8; D000099232:Proto-Oncogene Protein Spi-1; C493728:RUNX1 protein, human; C493726:Runx1 protein, mouse