Free radical damage in nasal polyp tissue.
OBJECTIVE
To investigate whether the free radical injury in nasal polyp tissue exists or not.


METHODS
A prospective study in patients with nasal polyps.


METHODS
Polyp specimens were obtained from 19 patients. Control specimens were acquired from 16 patients who underwent partial turbinectomy with concha bullosa free of rhinitis, sinusitis, and allergy, confirmed by endoscopic nasal examination, coronal paranasal sinus CT scan, and prick test. MDA levels of nasal polyps and control specimens were measured by using the method of Knudsen et al.


RESULTS
The mean MDA levels of nasal polyps and control specimens were 38.2 +/- 5.1 (33.3-52.2) and 33.9 +/- 1.6 (32.6-37.4), respectively. MDA levels in NP were significantly higher compared with control specimens (P < 0.01).


CONCLUSIONS
High level of MDA in nasal polyp tissue that represents FR increase supports the existence of cell injury in nasal polyp tissue. FRs should be considered in the development and life cycles of NP which is thought to have multifactorial pathogenesis.
Doğru
H
H
ENT-Head and Neck Surgery Department and Biochemistry Department, Süleyman Demirel University, School of Medicine, Isparta, Turkey. mutuz@hotmail.com
Delibaş
N
N
Döner
F
F
Tüz
M
M
Uygur
K
K
D000328:Adult; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008875:Middle Aged; D009298:Nasal Polyps / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D011446:Prospective Studies
D005609:Free Radicals; D008315:Malondialdehyde