The renin-angiotensin system and natriuretic peptides in obesity-associated hypertension.
Excessive accumulation of adipose tissue is associated with profound alterations in the cardiovascular system. including an increase in systemic blood pressure. It now appears clear that a central feature of obesity-associated hypertension is related to changes in sodium handling that may result from abnormalities in sympathetic nervous system activity, the renin-angiotensin-aldosterone system, natriuretic peptides, and kidney function. In this paper we review the role of these factors in the development of obesity-associated hypertension, thereby focusing on the potential role of adipose tissue in these alterations.
Engeli
S
S
Department of Nephrology and Hypertension, Franz-Volhard-Klinik, Universitätsklinikum Charité, Humboldt Universität, Berlin, Germany.
Sharma
A M
AM
D000273:Adipose Tissue / Q000502:physiology*; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D006973:Hypertension / Q000209:etiology*; D008954:Models, Biological; D009765:Obesity / Q000150:complications*; D012084:Renin-Angiotensin System / Q000502:physiology*; D012108:Research Personnel; D012964:Sodium / Q000378:metabolism
D009320:Atrial Natriuretic Factor; D012964:Sodium