Cord blood endothelin-1 and perinatal asphyxia.
Discordant data have been reported on endothelin-1 (ET-1), a potent endothelium-derived vasoconstriction peptide, during the neonatal period, and elevated levels have been found in various neonatal diseases. This study evaluated ET-1 in the cord blood of 74 neonates of different gestational age, birthweight, mode of delivery and 5'-Apgar score.


CONCLUSIONS
Higher ET-1 levels were found in neonates born by emergency caesarean section, and in newborns with low 5'-Apgar score, suggesting that ET-1 could be a marker of perinatal asphyxia.
Laforgia
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N
Dipartimento di Biomedicina dell'Età Evolutiva, Università degli Studi di Bari, Italy. n.laforgia@neonatologia.uniba.it
Difonzo
I
I
Altomare
M
M
Mautone
A
A
D001238:Asphyxia Neonatorum / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D019332:Endothelin-1 / Q000097:blood*; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn
D015415:Biomarkers; D019332:Endothelin-1