title: Exonic variants of the GABA(B) receptor gene and panic disorder.
abstract: The enhancement of GABAergic neurotransmission has been closely linked to antipanic drug efficacy. This is the first study to investigate a putative association of exonic sequence variants of the human GABA(B) receptor 1 (GABA(B)R1) gene and susceptibility to panic disorder. Three DNA sequence variants in exons 1a1, 7 and 11 were assessed by polymerase chain reaction-based restriction fragment length polymorphism in a case-control study among patients with panic disorder with and without agoraphobia (DSM III-R criteria) and blood donors. There was no indication of an increased vulnerability to panic disorder or agoraphobia with respect to the allelic variants under study.
authors.affiliation: Department of Psychiatry, University of Würzburg, Germany. philipp.sand@mail.uni-wuerzburg.de
authors.forename: P G
authors.initials: PG
authors.lastname: Sand
authors.forename: C
authors.initials: C
authors.lastname: Godau
authors.forename: P
authors.initials: P
authors.lastname: Riederer
authors.forename: C
authors.initials: C
authors.lastname: Peters
authors.forename: P
authors.initials: P
authors.lastname: Franke
authors.forename: M M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: G
authors.initials: G
authors.lastname: Stöber
authors.forename: J
authors.initials: J
authors.lastname: Fritze
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: P
authors.initials: P
authors.lastname: Propping
authors.forename: K P
authors.initials: KP
authors.lastname: Lesch
authors.forename: O
authors.initials: O
authors.lastname: Riess
authors.forename: T
authors.initials: T
authors.lastname: Sander
authors.forename: H
authors.initials: H
authors.lastname: Beckmann
authors.forename: J
authors.initials: J
authors.lastname: Deckert
mesh_terms: D000379:Agoraphobia / Q000150:complications / Q000235:genetics*; D000483:Alleles; D019943:Amino Acid Substitution; D016022:Case-Control Studies; D004247:DNA / Q000097:blood / Q000235:genetics; D005091:Exons; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D005858:Germany; D006801:Humans; D008297:Male; D016584:Panic Disorder / Q000150:complications / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D018080:Receptors, GABA-B / Q000235:genetics*; D017422:Sequence Analysis, DNA; D044465:White People / Q000235:genetics
chemical_list: D018080:Receptors, GABA-B; D004247:DNA