[Effect of levodopa on visual evoked potential in amblyopia].
OBJECTIVE
To evaluate the efficacy of levodpa treatment for amblyopia.


METHODS
The patients with amblyopin were given a single dose of levodopa, and the normal control group was established with the other normal eye in unilateral amblyopia. Their pattern visual evoked potential(PVEP) were tested before and after taking levodopa.


RESULTS
After taking a single dose of levodopa, the PVEP in the normal eyes showed that the N1P1 amplitudes evoked by middle spatial frequency stimuli and the P1N2 amplitudes evoked by high spatial frequency stimuli increased, however, in the amblyopic eyes showed that the N1 latency evoked by low spatial frequency stimuli and P1 latency evoked by middle spatial frequency decreased.


CONCLUSIONS
A single dose of levodopa administration can induce improvement of PVEP in the amblyopic eyes, and levodopa may be efficacious in the amblyopic therapy.
Den
D
D
Zongshan Ophthalmic Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
Long
S
S
Mai
G
G
Wu
D Z
DZ
Chen
G
G
D000293:Adolescent; D000328:Adult; D000550:Amblyopia / Q000188:drug therapy / Q000503:physiopathology*; D002648:Child; D015259:Dopamine Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male
D015259:Dopamine Agents; D007980:Levodopa