[Ketamine pharmacokinetics and metabolism after bolus injection of X-ray contrast agents in roentgeno-endovascular interventions in children].
The study was carried out on 13 children (2-12 years) subjected to abdominal aortography. The children were divided into 2 groups. Changes in plasma concentrations of ketamine and its metabolism were evaluated during anesthesia after bolus injection of ionic highly osmolar and nonionic low-osmolar x-ray contrast agents (RCA). Injection of an RCA bolus was associated with a 2-fold more rapid drop of the anesthetic concentration in the blood, increase of renal clearance of ketamine and its metabolites; the osmotic effect of ionic highly osmolar and nonionic low-osmolar RCA on ketamine pharmacokinetics virtually did not differ.
Lazarev
V V
VV
Galibin
I E
IE
Savchuk
S A
SA
Izotov
B N
BN
Vedenin
A N
AN
Vasina
R P
RP
D000367:Age Factors; D000778:Anesthetics, Dissociative / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics; D001012:Aorta, Abdominal / Q000000981:diagnostic imaging*; D001027:Aortography; D002648:Child; D002675:Child, Preschool; D002845:Chromatography; D003287:Contrast Media / Q000008:administration & dosage*; D006801:Humans; D007649:Ketamine / Q000097:blood* / Q000378:metabolism / Q000493:pharmacokinetics; D013058:Mass Spectrometry
D000778:Anesthetics, Dissociative; D003287:Contrast Media; D007649:Ketamine