Xenopus frizzled-5: a frizzled family member expressed exclusively in the neural retina of the developing eye.
We have isolated a new Wnt receptor frizzled family member from Xenopus laevis, Xenopus frizzled-5 (Xfz5), a likely ortholog of human frizzled-5. Based on Northern and whole-mount in situ hybridization data, Xfz5 is first detected at the late neurula stage in retinal primordia. Throughout the tailbud stage Xfz5 is expressed exclusively in the neural retina within the optic vesicles. During tadpole stage Xfz5 expression becomes restricted to the ciliary marginal zone. This highly restrictive expression pattern makes Xfz5 an excellent marker for neural retinal tissue.
Sumanas
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Department of Genetics, Cell Biology and Development, University of Minnesota, 6-160 Jackson Hall, 321 Church Street SE, Minneapolis, MN 55455, USA.
Ekker
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D000595:Amino Acid Sequence; D000818:Animals; D015152:Blotting, Northern; D005123:Eye / Q000196:embryology*; D005136:Eye Proteins / Q000096:biosynthesis*; D051157:Frizzled Receptors; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D010802:Phylogeny; D012160:Retina / Q000196:embryology*; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013997:Time Factors; D014018:Tissue Distribution; D014981:Xenopus / Q000378:metabolism*; D029867:Xenopus Proteins
D005136:Eye Proteins; D051157:Frizzled Receptors; D029867:Xenopus Proteins; C432154:fzd5 protein, Xenopus