New macrolides and furan carboxylic acid derivative from the sponge-derived fungus Cladosporium herbarum.
Bioassay-guided fractionation of organic extracts of Cladosporium herbarum, isolated from the marine sponge Callyspongia aerizusa, yielded two new macrolide metabolites: pandangolide 3 and 4 (1 and 2) and the known fungal metabolites pandangolide 2 (3), cladospolide B (4), and iso-cladospolide B (5). Also isolated were the antimicrobially active (against Bacillus subtilis and Staphylococcus aureus) furan carboxylic acids: Sumiki's acid (6) and its new derivative, acetyl Sumiki's acid (7). All structures were elucidated by spectroscopic methods.
Jadulco
R
R
Institut für Pharmazeutische Biologie, Heinrich-Heine-Universität Düsseldorf, Universitätsststrasse 1, D-40225 Düsseldorf, Germany.
Proksch
P
P
Wray
V
V
Sudarsono
Berg
A
A
Gräfe
U
U
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects; D002963:Cladosporium / Q000737:chemistry*; D018942:Macrolides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D011161:Porifera / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D018942:Macrolides; C430187:pandangolide 3; C430186:pandangolide 4