Factor V Leiden mutation in postthrombotic and non-postthrombotic venous ulcers.
OBJECTIVE
To determine the prevalence of the factor V Leiden mutation in patients with postthrombotic and non-postthrombotic venous ulcers.


METHODS
Case-control study.


METHODS
Department of Dermatology, University Hospital of Zurich, Zurich, Switzerland.


METHODS
Seventy-three consecutive outpatients and inpatients with venous ulcers and 45 age- and sex-matched control subjects (matched to the 42 patients with postthrombotic syndrome).


METHODS
Frequency of postthrombotic and non-postthrombotic findings in patients with venous ulcers. Prevalence of the factor V Leiden mutation in these different subgroups.


RESULTS
Postthrombotic syndrome was identified as the cause of 42 (58%; 95% confidence interval [CI], 45%-69%) of 73 venous ulcers, and the remainder were caused by primary valvular insufficiency. In postthrombotic ulcers, the prevalence of the factor V Leiden mutation was 38% (95% CI, 24%-54%) (16/42), which corresponds to an odds ratio of 13.2 (95% CI, 2.8-62.3; P<.001). In non-postthrombotic venous ulcers, the prevalence was 16% (95% CI, 5%-34%) (5/31), which corresponds to an odds ratio of 3.2 (95% CI, 1.0-10.0; P =.07).


CONCLUSIONS
The factor V Leiden mutation is highly prevalent in patients with postthrombotic venous ulcers. Even patients with non-postthrombotic venous ulcers show a moderately elevated prevalence of the factor V Leiden mutation. Some of the latter might be misclassified because of near-to-perfect revascularization after asymptomatic deep venous thrombosis. However, as long as the therapeutic consequences of the factor V Leiden mutation are not established, systematic screening cannot be recommended in patients with venous ulcers.
Hafner
J
J
Department of Dermatology, University Hospital of Zurich, CH-8091 Zurich, Switzerland. jhafner@derm.unizh.ch
Kühne
A
A
Schär
B
B
Bombeli
T
T
Hauser
M
M
Lüthi
R
R
Hänseler
E
E
D000368:Aged; D000369:Aged, 80 and over; D016022:Case-Control Studies; D005165:Factor V / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D013927:Thrombosis / Q000150:complications*; D014647:Varicose Ulcer / Q000209:etiology* / Q000235:genetics*
C095381:factor V Leiden; D005165:Factor V