title: Magnetization transfer in MRI: a review.
abstract: This review describes magnetization transfer (MT) contrast in magnetic resonance imaging. A qualitative description of how MT works is provided along with experimental evidence that leads to a quantitative model for MT in tissues. The implementation of MT saturation in imaging sequences and the interpretation of the MT-induced signal change in terms of exchange processes and direct effects are presented. Finally, highlights of clinical uses of MT are outlined and future directions for investigation proposed.
authors.affiliation: Department of Medical Biophysics University of Toronto, Toronto, Canada. mark.henkelman@swchsc.on.ca
authors.forename: R M
authors.initials: RM
authors.lastname: Henkelman
authors.forename: G J
authors.initials: GJ
authors.lastname: Stanisz
authors.forename: S J
authors.initials: SJ
authors.lastname: Graham
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D006801:Humans; D046911:Macromolecular Substances; D018810:Magnetic Resonance Angiography; D008279:Magnetic Resonance Imaging; D008280:Magnetics; D014867:Water
chemical_list: D046911:Macromolecular Substances; D014867:Water