Protein kinase C isoenzyme: selective expression pattern of protein kinase C-&theta; during mouse development.
Protein kinase C (PKC)-&theta;, a serine/threonine protein kinase and novel PKC subfamily member, has been recently identified as an essential component of the T cell synapse which activates the NF-kB signaling cascade leading to expression of the IL-2 gene during T cell activation. By RNA in situ hybridization to whole-body embryo sections it is shown that the murine PKC&theta; is specifically expressed in tissues with hematopoietic and lymphopoietic activity. Expression is also evident in skeletal muscle. A further highly specific expression was observed in the peripheral and central nervous system which is described in detail. Expression in the brain persists up to adult stages.
Wilda
M
M
Abteilung Humangenetik, Universität Ulm, D-89069 Ulm, Germany.
Ghaffari-Tabrizi
N
N
Reisert
I
I
Utermann
G
G
Baier
G
G
Hameister
H
H
D000818:Animals; D001921:Brain / Q000196:embryology; D002531:Cerebellum / Q000196:embryology; D018076:DNA, Complementary / Q000378:metabolism; D015870:Gene Expression; D007527:Isoenzymes / Q000096:biosynthesis*; D051379:Mice; D008810:Mice, Inbred C57BL; D011493:Protein Kinase C / Q000096:biosynthesis*; D000074121:Protein Kinase C-theta; D014018:Tissue Distribution
D018076:DNA, Complementary; D007527:Isoenzymes; C489593:Prkcq protein, mouse; D011493:Protein Kinase C; D000074121:Protein Kinase C-theta