Expression of frizzled genes in mouse costochondral chondrocytes.
Protein products of frizzled genes are cell membrane receptors for Wnt proteins that play multiple roles during development. We examined the expression of nine frizzled genes in mouse chondrocytes, and detected transcripts of six of the nine genes. We also cloned the entire cDNA of mouse frizzled-1 and compared its cDNA sequence and the cysteine-rich and transmembrane domains of its translated product to sequences of frizzled-1 from C. elegans, Drosophila, chicken and human. We used the T31 Mouse/Hamster radiation hybrid panel to map the mouse frizzled-1 to mouse chromosome 5 (5 cM from the centromere), and frizzled-9 to mouse chromosome 5 (74 cM from the centromere).
Xu
L
L
Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA.
Tan
L
L
Goldring
M B
MB
Olsen
B R
BR
Li
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002358:Cartilage, Articular / Q000166:cytology; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology / Q000378:metabolism*; D002874:Chromosome Mapping; D018076:DNA, Complementary; D051157:Frizzled Receptors; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D043562:Receptors, G-Protein-Coupled; D017981:Receptors, Neurotransmitter / Q000235:genetics*; D012272:Ribs / Q000166:cytology
D018076:DNA, Complementary; C489740:FZD1 protein, human; D051157:Frizzled Receptors; C489739:Fzd1 protein, mouse; C403212:Fzd9 protein, mouse; D043562:Receptors, G-Protein-Coupled; D017981:Receptors, Neurotransmitter