PAProC: a prediction algorithm for proteasomal cleavages available on the WWW.
The first version of PAProC (Prediction Algorithm for Proteasomal Cleavages) is now available to the general public. PAProC is a prediction tool for cleavages by human and yeast proteasomes, based on experimental cleavage data. It will be particularly useful for immunologists working on antigen processing and the prediction of major histocompatibility complex class I molecule (MHC I) ligands and cytotoxic T-lymphocyte (CTL) epitopes. Likewise, in cases in which proteasomal protein degradation has been indicated in disease, PAProC can be used to assess the general cleavability of disease-linked proteins. On its web site (http://www.paproc.de), background information and hyperlinks are provided for the user (e.g., to SYFPEITHI, the database for the prediction of MHC I ligands).
Nussbaum
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AK
Universität Tübingen, Interfakultäres Institut für Zellbiologie, Abteilung Immunologie, Auf der Morgenstelle 15, 72076 Tübingen, Germany.
Kuttler
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C
Hadeler
K P
KP
Rammensee
H G
HG
Schild
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H
D000465:Algorithms; D000595:Amino Acid Sequence; D001665:Binding Sites / Q000235:genetics; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D016208:Databases, Factual; D000939:Epitopes / Q000235:genetics / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D007125:Immunogenetics; D020407:Internet; D008024:Ligands; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000378:metabolism*; D009154:Mutation; D010751:Phosphopyruvate Hydratase / Q000235:genetics / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics; D013379:Substrate Specificity; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D008024:Ligands; D009097:Multienzyme Complexes; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex; D010751:Phosphopyruvate Hydratase