title: Blood product use during routine open heart surgery: the impact of the centrifugal pump.
abstract: A prospective randomized study was done including 1,000 patients undergoing routine open heart surgery. Patients were randomly assigned to either a roller pump or a BioMedicus centrifugal pump with identical extracorporeal circuits. There were no significant differences between study groups. Actual blood products transfused and predicted transfusion requirements (using Cardiac RiskMaster) were examined as was chest tube drainage (CTD). The predicted transfusion requirement was 885 of 1,000 patients. Transfusions were required by 472 of 1,000. Risk factors as significant predictors of increased CTD and use of blood products were emergency surgery status, increased cross-clamp time, and higher predicted risk of mortality. The only significant predictor of decreased CTD was the use of a centrifugal pump. Predictors of increased length of stay were myocardial infarction, preoperative urea, age, and massive transfusion. Data provide evidence that use of the centrifugal pump improves patient outcomes by decreasing CTD and decreasing the requirements for transfusion, which results in a shorter hospital stay.
authors.affiliation: Department of Cardiothoracic Surgery, Heinrich-Heine University Hospital, Düsseldorf, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: C B
authors.initials: CB
authors.lastname: Mahoney
authors.forename: C
authors.initials: C
authors.lastname: Probst
authors.forename: H D
authors.initials: HD
authors.lastname: Schulte
authors.forename: E
authors.initials: E
authors.lastname: Gams
mesh_terms: D001803:Blood Transfusion; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D015505:Chest Tubes; D005260:Female; D006801:Humans; D007902:Length of Stay; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011446:Prospective Studies; D012307:Risk Factors