title: Geographical north-south decline in DNASE1*2 in Japanese populations.
abstract: Allele frequencies for human deoxyribonuclease I (DNase I) phenotypes were determined using blood samples from about 2000 Japanese subjects living in nine prefectures, and compared with one another. DNase I phenotyping was performed principally using isoelectric focusing electrophoresis and activity staining. The DNase I system was shown to have enhanced potential for anthropologic, genetic, and clinical studies of Japanese populations. DNase I phenotypes were analyzed to evaluate the degree of genetic variation at the DNASE1 locus. Our examination of DNase I types revealed a decreasing north-to-south gradient in the DNASE1 allele.
authors.affiliation: Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Takeshita
authors.forename: T
authors.initials: T
authors.lastname: Yasuda
authors.forename: Y
authors.initials: Y
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Mogi
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: H
authors.initials: H
authors.lastname: Shiono
authors.forename: K
authors.initials: K
authors.lastname: Sagisaka
authors.forename: I
authors.initials: I
authors.lastname: Yuasa
authors.forename: H
authors.initials: H
authors.lastname: Nishimukai
authors.forename: H
authors.initials: H
authors.lastname: Kimura
mesh_terms: D016022:Case-Control Studies; D003850:Deoxyribonuclease I / Q000235:genetics*; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D007564:Japan; D010641:Phenotype; D012111:Residence Characteristics
chemical_list: D003850:Deoxyribonuclease I