Laser non-contact drug delivery methods: mathematical and experimental substantiation.
This article outlines the existing methods for parenteral drug delivery. It also presents novel alternative methods based on laser technologies, namely laser impregnation and laser injection. A mathematical model is constructed to calculate laser impregnator's technical parameters, such as the energy density of laser radiation, pulse duration, and pulse repetition frequency. This model also makes it possible to estimate the increase in the diffusion rate of drug preparations when they are impregnated through multilayer structures, such as the skin. Moreover, this article presents experimental results on Er:YAG laser injection of various drug media, such as spirit solutions, aqueous solutions, and ointments. These preparations were injected into gelatinous gel and autopsy skin samples. Possible clinical application is considered for these laser transcutaneous drug delivery methods.
Zharov
V P
VP
Biomedical Technical Systems Department, N. E. Bauman Moscow State University of Technology, Russia. zharov@mx.bmstu.ru
Latyshev
A S
AS
D000279:Administration, Cutaneous; D000818:Animals; D016503:Drug Delivery Systems / Q000379:methods*; D066298:In Vitro Techniques; D007277:Injections, Jet; D007478:Iontophoresis; D007834:Lasers; D008954:Models, Biological; D010599:Pharmacokinetics; D015612:Phonophoresis; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013552:Swine