[Protective effect of erigeron injections on hepatotoxicity induced by intestinal ischemia-reperfusion in mice].
The liver injury was induced by intestinal ischemia-reperfusion and the protective effect of erigeron injection (EI) was studied in mice. The results showed that serum alanine transaminase (ALT) and glutathione S-transferase (GST) activity increased while the root of superior mesenteric artery was blocked with non-injury artery clap for 20 minute and reperfusion for 1 hour. EI could protect the above changes induced by intestinal ischemia-reperfusion. EI could reduce the activities of serum ALT and GST, decrease the content of hepatic MDA and significantly increase the activity of SOD. The pathological changes of hepatocytes induced by intestinal ischemia-reperfusion were less in EI groups. These results suggested that EI could protect the liver of mice from injury induced by intestinal ischemia-reperfusion. One of the mechanisms of hepatoprotective action was related to the antioxidative function of erigeron.
Zhang
Z
Z
Pharmacy Department of Zhongnan Hospital, Wuhan University, Wuhan 430071, China.
Sun
M
M
Wang
H
H
Le
J
J
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000737:chemistry* / Q000494:pharmacology; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007421:Intestine, Small / Q000098:blood supply*; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D051379:Mice; D020011:Protective Agents / Q000494:pharmacology*; D015427:Reperfusion Injury / Q000517:prevention & control*
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D020011:Protective Agents; D000410:Alanine Transaminase