title: Fetal splenic rupture following transfusion.
abstract: BACKGROUND
  Splenic rupture in the newborn is a rare complication in erythroblastosis fetalis. There are no reports of splenic rupture in the fetus affected by hemolytic disease of the newborn.
  
  
  METHODS
  A 41-year-old gravida 3, para 2-0-0-2 with severe rhesus alloimmunization was managed with serial intrauterine transfusions resulting in fetal death after the fourth procedure. Autopsy findings revealed intra-abdominal clotted blood and splenic capsular defects consistent with splenic rupture.
  
  
  CONCLUSIONS
  Fetal splenic rupture might occur in hemolytic disease of the newborn associated with splenomegaly. Acute hemodynamic changes with increased intra-abdominal pressure from intrauterine transfusion might precipitate splenic rupture. (Obstet Gynecol 2001;97:824-5.
authors.affiliation: Division of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, University of North Carolina at Chapel Hill, 214 MacNider Building, CB#7516, Chapel Hill, NC 27599-7516, USA. paul_whitecar@med.unc.edu
authors.forename: P W
authors.initials: PW
authors.lastname: Whitecar
authors.forename: N D
authors.initials: ND
authors.lastname: Depcik-Smith
authors.forename: R A
authors.initials: RA
authors.lastname: Strauss
authors.forename: K J
authors.initials: KJ
authors.lastname: Moise
mesh_terms: D000328:Adult; D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects*; D004899:Erythroblastosis, Fetal / Q000628:therapy*; D005260:Female; D005313:Fetal Death; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*; D011295:Prenatal Care; D012203:Rh Isoimmunization / Q000628:therapy*; D012422:Rupture, Spontaneous; D013163:Splenomegaly / Q000209:etiology*