[Antidepressant effect of water decoction of Rhizoma acori tatarinowii in the behavioural despair animal models of depression].
OBJECTIVE
To assess the antidepressant effect of the water decoction of Rhizoma acori tatarinowii.


METHODS
By using the rat forced swimming test and mouse tail suspension test models of depression, the antidepressant effect of Rhizoma acori tatarinowii was observed.


RESULTS
The water decoction of Rhizoma acori tatarinowii and Fluoxetine significantly shortened motionless time of rat forced swimming and despair time of mouse tail suspension in the two behavioural despair animal models of depression. Antidepressant effect of water decoction of Rhizoma acori tatarinowii showed dose-dependence in the certain degree. The effect of water decoction of Rhizoma acori tatarinowii was weaker than that of Fluoxetine. There was a significant difference between every dose group of Rhizoma acori tatarinowii and saline control group.


CONCLUSIONS
The water decoction of Rhizoma acori tatarinowii possessed obviously antidepressant effect in the behavioural despair animal models of depression.
Li
M
M
Guangdong College of Pharmacy, Guangzhou 510224.
Chen
H
H
D000818:Animals; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy / Q000523:psychology; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D005473:Fluoxetine / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley
D000928:Antidepressive Agents; D004365:Drugs, Chinese Herbal; D005473:Fluoxetine