Thiosugars. Part 9: synthesis and biological evaluation of some 4'-thio-L-arabino nucleoside analogues.
1-O-Acetyl-2,3,5-tri-O-benzyl-4-thio-L-arabinofuranose (10) was transformed into the corresponding cytidine derivative 9 and the adenosine derivative 12. Both nucleosides, as well as the previously reported uridine and thymidine analogues 2 and 3, were tested for their in vitro antiviral activity.
Wirsching
J
J
Institut für Organische Chemie der Universität Hamburg, Germany.
Voss
J
J
Adiwidjaja
G
G
Balzarini
J
J
De Clercq
E
E
D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D003562:Cytidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008968:Molecular Conformation; D018165:Orthoreovirus / Q000187:drug effects*; D013872:Thionucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D013936:Thymidine / Q000031:analogs & derivatives / Q000494:pharmacology; D014529:Uridine / Q000031:analogs & derivatives / Q000494:pharmacology; D014961:X-Ray Diffraction
D000998:Antiviral Agents; D013872:Thionucleosides; D003562:Cytidine; D000241:Adenosine; D013936:Thymidine; D014529:Uridine