Familial inheritance of crossed fused renal ectopia.
A family with dominant inheritance of a rare renal malformation is reported. The father and one son had left crossed fused ectopic and dysplastic kidneys and another son had a horseshoe kidney and vesicoureteral reflux. We discuss various potential pathogenetic mechanisms and propose that a defect in the timing of the proper reciprocal induction of the ureteric bud and the metanephric blastema is involved.
Rinat
C
C
Division of Pediatric Nephrology, Shaare Zedek Medical Center, Hebrew University-Hadassah School of Medicine, Jerusalem, Israel.
Farkas
A
A
Frishberg
Y
Y
D000328:Adult; D002675:Child, Preschool; D002828:Choristoma / Q000150:complications / Q000235:genetics* / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities* / Q000473:pathology*; D008297:Male; D014718:Vesico-Ureteral Reflux / Q000209:etiology / Q000235:genetics / Q000473:pathology