Idiopathic myelofibrosis developing isolated granulocytic sarcoma with der (1;7)(q10; p10) after splenectomy and finally transforming to acute myelogenous leukemia.
A 47-year-old female with idiopathic myelofibrosis developed isolated granulocytic sarcoma with der (1; 7)(q10; p10) after splenectomy, followed by acute myelogenous leukemia. The patient had myelofibrosis since 22 years of age, received splenectomy at 47 years, and developed isolated submandibular granulocytic sarcoma, 8 months later. Although the initial tumor disappeared after irradiation, recurrent tumors selectively appeared in the areas of operative scars. She subsequently developed blastic transformation with der (1; 7)(q10; p10), and the blasts were refractory to different chemotherapy. This case is very rare in the following aspects: the onset of myelofibrosis occurred at a relatively young age; isolated granulocytic sarcoma after splenectomy preceded the transformation to acute leukemia; and the subcutaneous tumors developed in areas of operative scars.
Kasahara
S
S
First Department of Internal Medicine, Gifu University School of Medicine, 40 Tsukasa-machi, Gifu 500-8705, Japan.
Tsurumi
H
H
Hara
T
T
Goto
H
H
Moriwaki
H
H
D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D002921:Cicatrix / Q000473:pathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics; D008339:Mandibular Neoplasms / Q000209:etiology / Q000235:genetics; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications* / Q000209:etiology; D012878:Skin Neoplasms / Q000209:etiology; D013156:Splenectomy / Q000009:adverse effects*; D014178:Translocation, Genetic