[Stevens-Johnson syndrome followed by Gougerot-Sjögren syndrome].
BACKGROUND
Sicca syndrome after Stevens-Johnson syndrome is classically described. However, to our knowledge, authentic Sjögren's syndrome following epidermal necrolysis has not been described previously.


METHODS
A 36-year-old woman with Steven-Johnson syndrome developed transient hepatitis and a persistent sicca syndrome. Fourteen years later an authentic Sjögren's syndrome was identified with presence of antinuclear and anti-SSA antibodies and lymphocytes infiltration of the accessory salivary glands, i.e. grade IV disease in the Chisholm classification.


CONCLUSIONS
The initial mucosal destruction observed in our patients may have laid the ground for Sjögren's syndrome via abnormal antigen presentation in a predisposed dysimmune context.
de Roux Serratrice
C
C
Service de Médecine interne, CHU Timone, 265, boulevard Jean Moulin, F 13385 Marseille. pdisdier@ap-hm.fr
Serratrice
J
J
Granel
B
B
Weiller-Merli
C
C
Rey
J
J
Lepidi
H
H
Disdier
P
P
Weiller
P J
PJ
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001706:Biopsy; D003937:Diagnosis, Differential; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D005500:Follow-Up Studies; D006801:Humans; D012469:Salivary Glands / Q000473:pathology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D013262:Stevens-Johnson Syndrome / Q000150:complications*; D013997:Time Factors
D000974:Antibodies, Antinuclear