Inhibition of cytokine-induced vascular cell adhesion molecule-1 expression; possible mechanism for anti-atherogenic effect of Agastache rugosa.
Adhesion molecules such as vascular cell adhesion molecule-1 (VCAM-1) play an important role during the early stages of atherogenesis. Agastache rugosa has an anti-atherogenic effect in low density lipoprotein receptor -/- mice. Moreover, A. rugosa reduced macrophage infiltration and VCAM-1 expression has been localized in aortic endothelium that overlies early foam cell lesions. This study ascertained that tilianin (100 microM), a major component of A. rugosa, inhibits the tumor necrotic factor-alpha (TNF-alpha)-induced expression of VCAM-1 by 74% in cultured human umbilical vein endothelial cells (HUVECs). Also, tilianin (100 microM) reduced TNF-alpha-induced activation of nuclear factor-kappaB in HUVECs.
Hong
J J
JJ
Genetics Resources Center, Korea Institute of Bioscience and Biotecknology, Yusong, Taejon, South Korea.
Choi
J H
JH
Oh
S R
SR
Lee
H K
HK
Park
J H
JH
Lee
K Y
KY
Kim
J J
JJ
Jeong
T S
TS
Oh
G T
GT
D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology; D006027:Glycosides / Q000494:pharmacology; D006801:Humans; D007150:Immunohistochemistry; D008074:Lipoproteins / Q000097:blood; D008264:Macrophages / Q000166:cytology; D051379:Mice; D018345:Mice, Knockout; D016328:NF-kappa B / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011973:Receptors, LDL / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis* / Q000276:immunology
D005419:Flavonoids; D006027:Glycosides; D008074:Lipoproteins; D016328:NF-kappa B; D010936:Plant Extracts; D011973:Receptors, LDL; D014409:Tumor Necrosis Factor-alpha; D019010:Vascular Cell Adhesion Molecule-1; C426884:tilianin