title: Tubular e-PTFE implants in glottal and neoglottal insufficiency: tolerance and stability in an animal model.
abstract: The aim of our research is to develop a laryngeal tissue augmentation technique that will be useful in treating glottal and neoglottal insufficiency. In a previous study the feasibility of insertion of tubular expanded poly-tetrafluoroethylene (e-PTFE) tissue implants into the larynx of a porcine model was demonstrated. In this paper we report the clinical, endoscopic, computed tomography (CT) and magnetic resonance image (MRI) and histopathological follow-up findings. These results demonstrate host tolerance of the implant over the period of study (six months) with little tissue reactivity to tubular e-PTFE implants in the porcine model. The tubular shape of the implant enhances stabilization by the rapid and complete host tissue penetration of the implant's interstices, making tubular e-PTFE a potentially useful soft tissue augmentation material for laryngeal incompetence.
authors.affiliation: Department of Otorhinolaryngology, Ospedale Maggiore Policlincio IRCCS, University of Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Tamplenizza
authors.forename: F
authors.initials: F
authors.lastname: Acocella
authors.forename: F
authors.initials: F
authors.lastname: Addis
authors.forename: E
authors.initials: E
authors.lastname: Bolandrini
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D007828:Laryngoscopy; D007830:Larynx / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D019060:Minimally Invasive Surgical Procedures / Q000379:methods; D011138:Polytetrafluoroethylene; D011184:Postoperative Period; D019736:Prostheses and Implants; D019919:Prosthesis Implantation / Q000379:methods; D013552:Swine; D014057:Tomography, X-Ray Computed; D014826:Vocal Cord Paralysis / Q000601:surgery*
chemical_list: D011138:Polytetrafluoroethylene