title: Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk.
abstract: Superoxide dismutases play a key role in the detoxification of superoxide radicals and thus protect cells from damage induced by free radicals. Within mitochondria manganese superoxide dismutase (MnSOD) provides a major defence against oxidative damage by reactive oxygen species. Polymorphism in the mitochondrial targeting sequence of MnSOD has recently been associated with risk of breast cancer. We examined this in a study population consisting of 483 breast cancer cases and 482 controls, all of Finnish Caucasian origin. Odds ratios (OR) and 95% confidence intervals (95% CIs) were estimated by unconditional logistic regression. MnSOD genotypes containing the variant A allele were found to be associated with a 1.5-fold (95% CI 1.1-2.0) increased risk of breast cancer compared with those with the homozygous wild-type genotype (MnSOD VV). This finding supports the proposal that MnSOD genotypes may modify individual breast cancer risk.
authors.affiliation: Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland.
authors.forename: K
authors.initials: K
authors.lastname: Mitrunen
authors.forename: P
authors.initials: P
authors.lastname: Sillanpää
authors.forename: V
authors.initials: V
authors.lastname: Kataja
authors.forename: M
authors.initials: M
authors.lastname: Eskelinen
authors.forename: V M
authors.initials: VM
authors.lastname: Kosma
authors.forename: S
authors.initials: S
authors.lastname: Benhamou
authors.forename: M
authors.initials: M
authors.lastname: Uusitupa
authors.forename: A
authors.initials: A
authors.lastname: Hirvonen
mesh_terms: D001483:Base Sequence; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers; D006801:Humans; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase / Q000235:genetics*
chemical_list: D017931:DNA Primers; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase