title: Comparison of source localization of interictal epileptic spike potentials in patients estimated by the dipole tracing method with the focus directly recorded by the depth electrodes.
abstract: The purpose of the study was to investigate the accuracy of location of equivalent current dipoles estimated by the dipole tracing method (DT) utilizing a realistic 3-shell (scalp-skull-brain) head model (SSB-DT). Three patients with intractable complex partial seizures, diagnosed as having typical temporal seizures were investigated. We recorded the interictal spike potentials with surface electrodes (International 10/20 system) and with intracerebral depth electrodes simultaneously. We compared the location of dipoles of the spikes estimated by the SSB-DT with the focus of the spikes determined by the recording from the depth electrodes. We found that the location of the dipoles estimated by SSB-DT corresponded to the location of the depth electrodes, which could record the epileptic spikes. This finding proved that SSB-DT is reliable and valid for estimating neural activity in deep locations such as the limbic system.
authors.affiliation: 2nd Department of Physiology, Showa University School of Medicine, Hatanodai 1-5-8, Shinagawa-ku, 142-8555, Tokyo, Japan. ihomma@med.showa-u.ac.jp
authors.forename: I
authors.initials: I
authors.lastname: Homma
authors.forename: Y
authors.initials: Y
authors.lastname: Masaoka
authors.forename: K
authors.initials: K
authors.lastname: Hirasawa
authors.forename: F
authors.initials: F
authors.lastname: Yamane
authors.forename: T
authors.initials: T
authors.lastname: Hori
authors.forename: Y
authors.initials: Y
authors.lastname: Okamoto
mesh_terms: D000200:Action Potentials / Q000502:physiology*; D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male