title: 60Cobalt vs. linear accelerator in the treatment of locally advanced cervix carcinoma: a comparison of survival and recurrence patterns.
abstract: OBJECTIVE
  To compare the survival and recurrence patterns of patients with locally advanced cervical carcinoma treated with 60cobalt radiotherapy units and linear accelerators.
  
  
  METHODS
  Two hundred and forty-eight patients with cervical carcinoma stages IIB-IVA who were treated with primary irradiation between the years 1985 and 1988 comprised the study group. The median survival of patients treated with 60cobalt units and linear accelerators was calculated using the method of Kaplan and Meier and compared using the log-rank test. Recurrence patterns were compared using chi-square analysis; p < .05 was considered significant for all tests.
  
  
  RESULTS
  One hundred and ninety-five patients were treated with 60cobalt units (Group 1) and 53 patients were treated with a linear accelerator (Group 2). Group 1 and 2 were similar with regard to mean age and weight, stage distribution, and mean dose to point A. The rate of recurrence was comparable between Group 1 and 2 (65.6% vs. 64.2%) and no significant difference was found in overall survival between the groups (20 months vs. 21 months. p = 81). There was a trend toward increasing pelvic recurrence in Group 1 (50.8%) compared to Group 2 (35.8%, p = .08).
  
  
  CONCLUSIONS
  60Cobalt units and linear accelerators offer comparable rates of overall survival in patients with locally advanced cervix carcinoma.
authors.affiliation: Department of Obstetrics and Gynecology, Kings County Hospital and State University of New York-Health Science Center at Brooklyn, USA.
authors.forename: K
authors.initials: K
authors.lastname: Holcomb
authors.forename: N
authors.initials: N
authors.lastname: Gabbur
authors.forename: T
authors.initials: T
authors.lastname: Tucker
authors.forename: R P
authors.initials: RP
authors.lastname: Matthews
authors.forename: Y C
authors.initials: YC
authors.lastname: Lee
authors.forename: O
authors.initials: O
authors.lastname: Abulafia
mesh_terms: D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D010315:Particle Accelerators; D010388:Pelvis / Q000528:radiation effects; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy / Q000295:instrumentation / Q000379:methods*; D015996:Survival Rate; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000532:radiotherapy*
chemical_list: D003037:Cobalt Radioisotopes