Diverse biological activity of polycaphenol.
Millimolar concentrations of alkaline extract of Cacao husk (polycaphenol) were more cytotoxic to human oral tumor cells (human oral squamous cell carcinoma HSC-2, human salivary gland tumor HSG), than to human gingival fibroblast (HGF), suggesting its tumor-specific action. Polycaphenol enhanced the radical intensity and cytotoxic activity of vitamin K3 more effectively than that of sodium ascorbate (vitamin C). Polycaphenol effectively scavenged the superoxide anion, produced by the hypoxanthine-xanthine oxidase reaction, indicating bimodal (prooxidant and antioxidant) action of polycaphenol. Polycaphenol inhibited the cytopathic effect of HIV (human immunodeficiency virus) infection in MT-4 cells, to a comparable extent as that achieved by lignin. Pretreatment of mice with polycaphenol protected them from lethal infection of Eschericia coli. These data suggest the medicinal efficacy of polycaphenol.
Jiang
Y
Y
Meikai Pharmaco-Medical Laboratory (MPL), Meikai University School of Dentistry, Sakado, Saitama, Japan.
Satoh
K
K
Aratsu
C
C
Komatsu
N
N
Fujimaki
M
M
Nakashima
H
H
Kanamoto
T
T
Sakagami
H
H
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002099:Cacao / Q000737:chemistry; D002294:Carcinoma, Squamous Cell; D003603:Cytotoxins / Q000494:pharmacology; D004927:Escherichia coli Infections / Q000188:drug therapy*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D016166:Free Radical Scavengers / Q000494:pharmacology*; D005881:Gingiva / Q000166:cytology*; D015658:HIV Infections / Q000188:drug therapy; D006801:Humans; D008031:Lignin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009062:Mouth Neoplasms; D012468:Salivary Gland Neoplasms; D014407:Tumor Cells, Cultured; D014815:Vitamins / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D003603:Cytotoxins; D016166:Free Radical Scavengers; D014815:Vitamins; C434583:polycaphenol; D008031:Lignin