title: Expanded polytetrafluoroethylene reinforcement material in glaucoma drain surgery.
abstract: OBJECTIVE
  To determine whether a synthetic material, expanded polytetrafluoroethylene (E-PTFE), can be used successfully as a reinforcement material over the tubes of glaucoma drainage implants.
  
  
  METHODS
  Patches of E-PTFE were sutured over the tubes of Baerveldt glaucoma drains implanted in the eyes of New Zealand white rabbits. Two material thicknesses were tested: 0.5 mm in four eyes and 0.25 mm in five eyes. Rabbit donor scleral patches were used in five eyes as the control. Total ocular health and intraocular pressure were monitored every 2 weeks after the procedure. Six months after implantation, the eyes were harvested and analyzed histologically.
  
  
  RESULTS
  Two of the four eyes that received 0.5-mm thick E-PTFE patches showed some conjunctival melting over the anterior corners of the material close to the limbus. All five eyes that received 0.25-mm thick E-PTFE patches showed a healthy cellular wound healing response and no conjunctival melting. Cellular infiltration and collagen deposition in the E-PTFE materials showed integration of the patch material into the surrounding tissue. In the control eyes, marked thinning and resorption of the donor sclera immediately above the drainage tube was noted.
  
  
  CONCLUSIONS
  Thin (0.25 mm) E-PTFE patches were well tolerated in all rabbit eyes tested. Thin E-PTFE should be investigated further as a functional alternative to donor sclera for reinforcement in glaucoma drain surgery.
authors.affiliation: Lions Eye Research Laboratories, LSU Eye Center, Louisiana State University Health Sciences Center School of Medicine, New Orleans 70112-2234, USA.
authors.forename: T
authors.initials: T
authors.lastname: Jacob
authors.forename: O J
authors.initials: OJ
authors.lastname: LaCour
authors.forename: C F
authors.initials: CF
authors.lastname: Burgoyne
authors.forename: P K
authors.initials: PK
authors.lastname: LaFleur
authors.forename: E
authors.initials: E
authors.lastname: Duzman
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D003094:Collagen / Q000378:metabolism; D005901:Glaucoma / Q000601:surgery*; D020327:Glaucoma Drainage Implants; D011138:Polytetrafluoroethylene; D019919:Prosthesis Implantation / Q000379:methods*; D011817:Rabbits; D012590:Sclera / Q000378:metabolism / Q000601:surgery; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D011138:Polytetrafluoroethylene; D003094:Collagen