title: Bacteremic infection with Pediococcus: vancomycin-resistant opportunist.
abstract: Pediococci are recently recognized Gram-positive human pathogens, resistant to vancomycin and generally susceptible to penicillin. Infection in adults has been seen in patients with chronic underlying conditions as well as those with previous abdominal surgery. Two previous infants with congenital gastrointestinal malformations requiring surgical correction have been reported with sepsis attributable to Pediococcus sp. We report a third infant born with gastroschisis who developed Pediococcus bacteremia and meningitis 3 months after surgery, and speculate regarding the role of probiotics in the pathogenesis of this infection.
authors.affiliation: Department of Pediatrics and Steele Memorial Children's Research Center, University of Arizona, Tucson, AZ 85724-5073, USA. llb@peds.arizona.edu
authors.forename: L L
authors.initials: LL
authors.lastname: Barton
authors.forename: E D
authors.initials: ED
authors.lastname: Rider
authors.forename: R W
authors.initials: RW
authors.lastname: Coen
mesh_terms: D016470:Bacteremia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D001421:Bacteria, Anaerobic / Q000145:classification / Q000187:drug effects / Q000472:pathogenicity; D005260:Female; D020139:Gastroschisis / Q000097:blood / Q000150:complications* / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D007363:Intensive Care Units, Neonatal / Q000706:statistics & numerical data; D007779:Lactobacillus acidophilus; D009894:Opportunistic Infections / Q000097:blood / Q000188:drug therapy*; D010376:Pediococcus / Q000145:classification / Q000187:drug effects* / Q000472:pathogenicity*; D010406:Penicillins / Q000627:therapeutic use; D019936:Probiotics / Q000009:adverse effects / Q000627:therapeutic use; D020713:Vancomycin Resistance
chemical_list: D010406:Penicillins