Scleroderma in a child after chemotherapy for cancer.
The association of malignancy with scleroderma is very rare in childhood. A 13-year-old girl was diagnosed as having thymic carcinoma and received systemic chemotherapy. She presented with symptoms of Raynaud's phenomenon 9 months after the cessation of chemotherapy. She also had difficulty in swallowing. Based on the presence of Raynaud's phenomenon, characteristic skin changes over the face and hands, oesophageal involvement and pulmonary restrictive defect demonstrated by pulmonary function tests, the diagnosis of generalised scleroderma was established. There was no evidence of tumor recurrence. Although she was treated with penicillamine and prednisolone, no significant improvement was achieved in her condition during the 14-month follow up.
Emir
S
S
Department of Pediatric Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey.
Kutluk
T
T
Topaloğlu
R
R
Bakkaloğlu
A
A
Büyükpamukçu
M
M
D000293:Adolescent; D018906:Antineoplastic Agents, Alkylating / Q000009:adverse effects; D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002945:Cisplatin / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D005260:Female; D006801:Humans; D012595:Scleroderma, Systemic / Q000139:chemically induced*; D013945:Thymoma / Q000150:complications* / Q000188:drug therapy*; D013953:Thymus Neoplasms / Q000150:complications* / Q000188:drug therapy*; D014750:Vincristine / Q000009:adverse effects
D018906:Antineoplastic Agents, Alkylating; D000972:Antineoplastic Agents, Phytogenic; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin