Lactase deficiency among Malaysian children with recurrent abdominal pain.
OBJECTIVE
To determine the prevalence of lactase deficiency among Malaysian children with recurrent abdominal pain and to describe their clinical characteristics.


METHODS
Twenty-four children referred consecutively to the University of Malaya Medical Centre who fulfilled Apley's criteria (at least three episodes of abdominal pain severe enough to affect normal activity over a period longer than 3 months) were tested for lactase deficiency using a pocket breath test analyser (BreatH2 meter; Europa Scientific, Cheshire, England). Lactulose was used to check for hydrogen-producing capacity.


RESULTS
There were 14 males and 10 females in the study, consisting of five Malays, 14 Chinese and five Indians. Mean age was 9.9 years. Seventeen of the 24 children (70.8%) with recurrent abdominal pain who underwent the breath hydrogen test had a positive result. In those with a negative result, subsequent lactulose administration resulted in a positive rise in breath hydrogen. None of the 24 children developed abdominal pain during the test. All the Indian subjects, 71.4% of the Chinese subjects and 40% of the Malay subjects with recurrent abdominal pain had lactase deficiency. The proportion of boys and girls with lactase deficiency was similar (71.4 vs 70.0%, respectively). There was no significant difference between lactase sufficient and deficient children with recurrent abdominal pain with regard to sex, age, ethnic group and clinical features. Following a lactose-free diet, none of the children in the breath hydrogen positive and negative groups reported any appreciable difference in pain symptoms.


CONCLUSIONS
The prevalence of lactase deficiency among this group of Malaysian children with recurrent abdominal pain was high, but lactase deficiency did not appear to play an important role in causing the symptoms.
Boey
C C
CC
Department of Paediatrics, University of Malaya Medical Centre, Kuala Lumpur, Malaysia. boeycm@medicine.med.um.edu.my
D015746:Abdominal Pain / Q000209:etiology*; D000293:Adolescent; D001944:Breath Tests; D015984:Causality; D002648:Child; D002675:Child, Preschool; D005006:Ethnicity; D005260:Female; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D008296:Malaysia; D008297:Male; D012008:Recurrence; D001616:beta-Galactosidase / Q000008:administration & dosage / Q000172:deficiency*
D006859:Hydrogen; D001616:beta-Galactosidase