title: Drug discovery and the intracellular receptor family.
abstract: Drug discovery using intracellular receptors (IRs) as targets presents its own set of unique complications and advantages. The natural ligands for these receptors are, in many cases, already used as drugs. To effectively exploit these targets, newer molecules must have either increased receptor selectivity or increased tissue or gene selectivity to reduce side effects. The search for these molecules will yield new therapeutics as well as new insights into the mechanism of action of these receptors and their ligands.
authors.affiliation: Endocrine Research, Ligand Pharmaceuticals, San Diego, California 92121, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Miner
authors.forename: C M
authors.initials: CM
authors.lastname: Tyree
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D015195:Drug Design; D006801:Humans; D008024:Ligands; D008958:Models, Molecular; D011956:Receptors, Cell Surface / Q000378:metabolism*
chemical_list: D008024:Ligands; D011956:Receptors, Cell Surface