Behavior-dependent states of the hippocampal network affect functional clustering of neurons.
Local versus distant coherence of hippocampal CA1 pyramidal cells was investigated in the behaving rat. Temporal cross-correlation of pyramidal cells revealed a significantly stronger relationship among local (<140 microm) pyramidal neurons compared with distant (>300 microm) neurons during non-theta-associated immobility and sleep but not during theta-associated running and walking. In contrast, cross-correlation between local pyramidal cell-interneuron pairs was significantly stronger than between distant pairs during theta oscillations but were similar during non-theta-associated behaviors. We suggest that network state-dependent functional clustering of neuronal activity emerges because of the differential contribution of the main excitatory inputs, the perforant path, and Schaffer collaterals during theta and non-theta behaviors.
Hirase
H
H
Center for Molecular and Behavioral Neuroscience, Rutgers, The State University of New Jersey, Newark, New Jersey 07102, USA.
Leinekugel
X
X
Csicsvari
J
J
Czurkó
A
A
Buzsáki
G
G
D000200:Action Potentials / Q000502:physiology; D000204:Activity Cycles / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D001683:Biological Clocks / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000502:physiology*; D007395:Interneurons / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D019580:Perforant Pathway / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology; D051381:Rats; D020318:Rats, Long-Evans; D012890:Sleep / Q000502:physiology; D013826:Theta Rhythm