title: Hair diameter diversity: a clinical sign reflecting the follicle miniaturization.
abstract: BACKGROUND
  The degree of androgenetic alopecia is generally evaluated either by global clinical scales or time-consuming methods like phototrichogram or histological studies. We describe a new clinical and reliable scoring method based on hair diameter diversity.
  
  
  METHODS
  (1) The clinical macroscopic scoring we propose for hair density was significantly correlated with Hamilton classification and with histological hair density. (2) Diversity in hair diameter was the main and most accurate clinical parameter linked to follicle miniaturization. (C) The anagen-telogen ratio decreased in parallel with the decrease in clinical hair density score.
  
  
  CONCLUSIONS
  Considering that hair follicle miniaturization is the key point during androgenic alopecia onset and development, diversity in hair diameter represents an important feature to consider as an accurate clinical sign reflecting hair follicle miniaturization. Moreover, diversity in hair diameter seems to be an easily accessible and reliable parameter that should be taken into consideration for further characterization of hair disorders. By itself, we believe that this clinical feature constitutes a new tool of substantial help for the diagnosis and management of androgenic alopecia.
authors.affiliation: L'Oréal Research, Life Science, Prospective Clinical Research, 90 rue du Général Roguet, Clichy 92100, France. odelacharriere@recherche.loreal.com
authors.forename: O
authors.initials: O
authors.lastname: de Lacharrière
authors.forename: C
authors.initials: C
authors.lastname: Deloche
authors.forename: C
authors.initials: C
authors.lastname: Misciali
authors.forename: B M
authors.initials: BM
authors.lastname: Piraccini
authors.forename: C
authors.initials: C
authors.lastname: Vincenzi
authors.forename: P
authors.initials: P
authors.lastname: Bastien
authors.forename: I
authors.initials: I
authors.lastname: Tardy
authors.forename: B A
authors.initials: BA
authors.lastname: Bernard
authors.forename: A
authors.initials: A
authors.lastname: Tosti
mesh_terms: D000328:Adult; D000505:Alopecia / Q000209:etiology / Q000473:pathology*; D000728:Androgens / Q000502:physiology; D001706:Biopsy; D006197:Hair / Q000473:pathology*; D018859:Hair Follicle / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000728:Androgens