Cortical spreading depression during streptozotocin-induced hyperglycaemia in nutritionally normal and early-malnourished rats.
Cortical spreading depression (SD) was investigated in adult rats during Streptozotocin (STZ)-induced hyperglycaemia (group S; n=13). SD velocities of propagation were significantly lower than in the controls injected only with vehicle solution (group V; n=17). In contrast, rats rendered hypoglycaemic by food restriction+insulin for 3 days (group HG; n=9) presented SD velocities significantly higher than controls; this effect was reversed by injecting glucose during the recording session. SD velocity in early-malnourished rats was not different during STZ-hyperglycaemia (group MS; n=8) compared with previously-malnourished rats injected with vehicle (group MV; n=9). The data indicate an inverse relationship between glycaemia changes and SD propagation in well-nourished rats. Early malnutrition seems to abolish the effect of STZ-hyperglycaemia on SD.
Costa-Cruz
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RR
Departamento de Fisiologia e Farmacologia, Universidade Federal de Pernambuco, PE, Recife, Brazil.
Guedes
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RC
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism* / Q000503:physiopathology; D013181:Cortical Spreading Depression / Q000187:drug effects / Q000502:physiology*; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D005508:Food Deprivation / Q000502:physiology; D006943:Hyperglycemia / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D007003:Hypoglycemia / Q000150:complications / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009748:Nutrition Disorders / Q000150:complications* / Q000378:metabolism / Q000503:physiopathology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D001786:Blood Glucose; D011189:Potassium Chloride