title: [Cryoapheresis in the treatment of patients with cryoglobulinemic mesangiocapillary glomerulonephritis and acute kidney failure].
abstract: OBJECTIVE
  To assess cryoapheresis (CA) efficacy in the treatment of cryoglobulinemic glomerulonephritis (CG) with acute renal failure (ACR).
  
  
  METHODS
  Ten 34-64-year-old CG patients with associated HCV infection and symptoms of ACR (diuresis under 500 ml/day, serum creatinin 1.6-8.1 ml/dl). All the patients were examined clinically, for serum cryoglobulins, HCV, HBV markers, morphologically (renal and hepatic biopsies in 8 patients). All the patients received therapy with CA, immunodepressants. Three patients with virus replication received, in addition, antiviral drugs (alpha-interferon in a dose 3,000,000-5,000,000 IU 3 times a week intramuscularly for 6 months).
  
  
  RESULTS
  CA in combined CG therapy led to fast elimination of cryoglobulins from the body, stabilization of renal function with arrest of rapid progression of renal failure, normalization of diuresis with subsequent lowering of serum creatinin. The course of CA normalized renal function fully in 3 patients, partially in 7 patients. Later, these 7 patients developed chronic renal failure. Complete elimination of the virus and remission of CG were achieved in 2 of 3 patients who had undergone the antiviral treatment for a year.
  
  
  CONCLUSIONS
  CA can be added to combined therapy of CG aggravation as it improves renal function.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Milovanov
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Komiagin
authors.forename: L V
authors.initials: LV
authors.lastname: Kozlovskaia
authors.forename: N B
authors.initials: NB
authors.lastname: Gordovskaia
mesh_terms: D058186:Acute Kidney Injury / Q000628:therapy*; D000328:Adult; D001781:Blood Component Removal / Q000379:methods; D003449:Cryoglobulinemia / Q000150:complications / Q000628:therapy*; D005260:Female; D005500:Follow-Up Studies; D015432:Glomerulonephritis, Membranoproliferative / Q000628:therapy*; D006526:Hepatitis C / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007372:Interferons / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D007372:Interferons