title: CYFRA 21-1, TPA-M, TPS, SCC-Ag and CEA in patients with squamous cell lung cancer and in chemical industry workers as a reference group.
abstract: In etiology of lung cancer chemical carcinogenesis seems to be a very important factor. In the studies presented here the diagnostic usefulness of tumor markers in lung cancer was evaluated, using as a reference group workers of a chemical plant producing chromite and chromate pigments. The investigations of CYFRA 21-1, TPA-M, TPS, CEA and SCC-Ag were performed before treatment in a group of 76 squamous cell lung cancer patients in different stages of disease and in a reference group of 75 workers of the chemical company, who had been exposed to hexavalent chromium for longer than 1 year and had no clinical or radiological symptoms of lung diseases. In the squamous cell lung cancer group concentrations of all analyzed tumor markers were considered to be significantly higher than in the reference group. TPA assay demonstrated higher diagnostic performance than CYFRA 21-1 and the remaining tumor markers. At 0.95 specificity, the sensitivity of TPA was 0.79, CYFRA 21-1 -0.76, of TPS -0.29 whilst of CEA and SCC-Ag -0.31. The univariate analysis showed a significant prognostic value for clinical stages, only for CYFRA 21-1 and SCC-Ag. A significant relationship between marker level and survival was observed for CYFRA 21-1 as well as SCC-Ag levels. In a multivariate analysis CYFRA 21-1 and/or TPS remained significant predictors of survival.
authors.affiliation: Department of Clinical Biochemistry, Oncological Center, Cracow Division, ul. Garncarska 11, 31-115 Cracow, Poland. z5jkulpa@cyf-kr.edu.pl
authors.forename: J
authors.initials: J
authors.lastname: Kulpa
authors.forename: E
authors.initials: E
authors.lastname: Wójcik
authors.forename: A
authors.initials: A
authors.lastname: Radkowski
authors.forename: L
authors.initials: L
authors.lastname: Kolodziejski
authors.forename: Z
authors.initials: Z
authors.lastname: Stasik
mesh_terms: D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000737:chemistry / Q000175:diagnosis* / Q000401:mortality; D002617:Chemical Industry; D005260:Female; D006801:Humans; D053539:Keratin-19; D007633:Keratins; D008175:Lung Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000032:analysis; D012015:Reference Standards; D015843:Serpins; D015996:Survival Rate; D019396:Tissue Polypeptide Antigen / Q000032:analysis; D000078329:Workforce
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D053539:Keratin-19; D010455:Peptides; D015843:Serpins; D019396:Tissue Polypeptide Antigen; C102012:antigen CYFRA21.1; C051072:squamous cell carcinoma-related antigen; C089984:tissue polypeptide specific antigen; D007633:Keratins