Lithium intoxication due to carbamazepine-induced renal failure.
OBJECTIVE
To report the case of a patient with manic-depressive disorder who developed lithium intoxcation following carbamazepine-induced acute renal failure.


METHODS
A 33-year-old white man with bipolar manic-depressive disorder was treated with lithium for the last 18 months. Three weeks prior to admission, carbamazepine 600 mg was added to the drug regimen due to a recurrence of the psychiatric disorder. He was admitted wh signs of lithium intoxication. Acute renal failure due to carbamazepine-induced interstitial nephritis was diagnosed.


CONCLUSIONS
The combination of carbamazepine and lithium is known to cause neurotoxicity. We describe a different interaction in which the toxic lithium concentrations were the result of carbamazepine-induced acute renal failure.


CONCLUSIONS
When considering adding carbamazepine to lithium, careful follow-up of the patients is warranted to prevent this indirect drug in interaction.
Mayan
H
H
Department of Medicine E, Chaim Sheba Medical Center, Tel-Hashomer, Sackler School of Medicine, Tel-Aviv University, Israel. mayan@post.tau.ac.il
Golubev
N
N
Dinour
D
D
Farfel
Z
Z
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D001714:Bipolar Disorder / Q000188:drug therapy*; D002220:Carbamazepine / Q000009:adverse effects*; D004347:Drug Interactions; D006801:Humans; D008094:Lithium / Q000009:adverse effects*; D008297:Male
D000927:Anticonvulsants; D002220:Carbamazepine; D008094:Lithium