title: Pancreatic adenocarcinoma: detection and staging with dynamic MR imaging.
abstract: OBJECTIVE
  To compare the efficacy of dynamic contrast-enhanced MR imaging and spin-echo T1-weighted with and without fat-saturated MR imaging in the detection and staging of pancreatic adenocarcinoma.
  
  
  METHODS
  Spin-echo T1-weighted, fat-saturated T1-weighted and dynamic breath-hold 2D-FLASH MR imaging were performed in 25 patients with pancreatic adenocarcinoma. MR images were analysed by calculating the CNR between tumor and normal portion of the pancreas. The CNRs calculated at each sequences were compared. A total of 16 out of 25 patients underwent surgery. Preoperative staging according to TNM classification was also done in patients undergoing surgery.
  
  
  RESULTS
  The CNR was significantly different (P<0.05) in the arterial phase of dynamic MR images. The accuracy of 'T' staging was 75% for SE T1-W, fat-saturated T1-W and arterial phase of dynamic MR images.
  
  
  CONCLUSIONS
  The CNRs between pancreatic carcinoma and normal pancreas is significantly higher in dynamic MR sequences than the SE T1-W, fat-saturated T1-W sequences. However, the accuracy of tumor staging according to TNM is equivocal to SE T1-W and fat-saturated T1-W images.
authors.affiliation: Dokuz Eylül University School of Medicine, Department of Radiology, Izmir, Turkey. fobuz@deu.edu.tr
authors.forename: F
authors.initials: F
authors.lastname: Obuz
authors.forename: O
authors.initials: O
authors.lastname: Dicle
authors.forename: A
authors.initials: A
authors.lastname: Coker
authors.forename: O
authors.initials: O
authors.lastname: Sağol
authors.forename: S
authors.initials: S
authors.lastname: Karademir
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000473:pathology*