title: Clinical indications for use of fresh frozen plasma in dogs: 74 dogs (October through December 1999).
abstract: OBJECTIVE
  To document reasons for use of fresh frozen plasma (FFP) in dogs and determine variables that apparently triggered the decision to use FFP.
  
  
  METHODS
  Retrospective study.
  
  
  METHODS
  74 dogs.
  
  
  METHODS
  Medical records of dogs that received FFP at a veterinary teaching hospital during a 3-month period were reviewed.
  
  
  RESULTS
  The 74 dogs underwent 144 transfusion episodes (TE; a TE was defined as 1 day of transfusion therapy) and received 252 units (120 ml/unit) of FFP. Fresh frozen plasma was administered to provide coagulation factors (67 TE), albumin (91), alpha-macroglobulin (15), or immunoglobulins (19); for some TE, multiple clinical indications were identified. Variables that apparently triggered the decision to administer FFP included active hemorrhage with or without prolongation of coagulation times, low total plasma protein concentration, persistent vomiting associated with pancreatitis, and sepsis. Mean doses of FFP for each indication were between 8.5 and 9.4 ml/kg (3.9 and 4.3 ml/lb). Small dogs were generally given higher doses (mean dose, 13.9 ml/kg [6.3 ml/lb]) than large dogs (mean dose, 5.1 ml/kg [2.3 ml/lb]). Fifty (68%) dogs were alive at the time of discharge from the hospital.
  
  
  CONCLUSIONS
  Results suggest that FFP plays an important role in the care of critically ill dogs. Because the supply of FFP is limited, guidelines for when administration of FFP may be clinically useful should be developed.
authors.affiliation: Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Logan
authors.forename: M B
authors.initials: MB
authors.lastname: Callan
authors.forename: K
authors.initials: K
authors.lastname: Drew
authors.forename: K
authors.initials: K
authors.lastname: Marryott
authors.forename: D A
authors.initials: DA
authors.lastname: Oakley
authors.forename: L
authors.initials: L
authors.lastname: Jefferies
authors.forename: U
authors.initials: U
authors.lastname: Giger
mesh_terms: D000818:Animals; D016913:Blood Component Transfusion / Q000662:veterinary*; D001803:Blood Transfusion; D001835:Body Weight; D016638:Critical Illness / Q000628:therapy*; D004283:Dog Diseases / Q000097:blood / Q000628:therapy*; D004285:Dogs; D005260:Female; D008297:Male; D010949:Plasma; D012189:Retrospective Studies