Inhibition of gastric acid secretion by saiboku-to, an oriental herbal medicine, in rats.
Intraduodenal saiboku-to (250-1000 mg/kg) dose-dependently reduced gastric acid secretion and histamine output, without altering acetylcholine output in pylorus-ligated rats. Saiboku-to also inhibited subcutaneous bethanechol (1 mg/kg) and tetragastrin (0.3 mg/kg) -induced increases in gastric acid secretion in vagotomized pylorus-ligated rats; however, it did not inhibit subcutaneous histamine (20 mg/kg) -induced increase in acid secretion. These results, taken together, suggest a possibility that saiboku-to may inhibit histamine release. Thus, the effect of saiboku-to on histamine release was directly investigated by using anti-dinitrophenyl IgE-sensitized rat peritoneal mast cells. Antigen (dinitrophenyl)-induced histamine release from the mast cells was clearly dose-dependently inhibited by saiboku-to at concentrations of 0.1-1.0 mg/ml. These results suggest that the inhibited gastric acid secretion with saiboku-to is due to inhibited histamine release.
Ikarashi
Y
Y
Department of Neuropsychopharmacology, Gunma University School of Medicine, Japan.
Yuzurihara
M
M
Maruyama
Y
Y
D000109:Acetylcholine / Q000032:analysis; D000818:Animals; D018723:Bethanechol / Q000494:pharmacology; D002478:Cells, Cultured; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000737:chemistry; D006632:Histamine / Q000032:analysis / Q000494:pharmacology; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D008407:Mast Cells / Q000276:immunology / Q000378:metabolism; D020835:Medicine, Kampo; D051381:Rats; D017208:Rats, Wistar; D013758:Tetragastrin / Q000494:pharmacology
D004365:Drugs, Chinese Herbal; D006634:Histamine H1 Antagonists; C045086:saiboku-to; D018723:Bethanechol; D013758:Tetragastrin; D006632:Histamine; D000109:Acetylcholine