title: Calcium signaling pathways in the enteric nervous system.
abstract: The intracellular calcium level is an important regulator of cellular functioning, and its tight regulation occurs at several levels. Influx of extracellular calcium occurs via voltage-gated channels in response to a depolarization, and "capacitative" extracellular calcium occurs with cellular calcium depletion. Intracellular release of calcium also occurs through both the inositol trisphosphate- and ryanodine-sensitive stores of calcium. The following will detail these events and recent discoveries in Ca2+ signaling, and will specifically focus on their role in the functioning of the enteric nervous system.
authors.affiliation: Department of Surgery, University of Michigan, Ann Arbor, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Turner
authors.forename: M W
authors.initials: MW
authors.lastname: Mulholland
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D020013:Calcium Signaling; D003600:Cytosol / Q000378:metabolism; D005110:Extracellular Space; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology; D007422:Intestines / Q000294:innervation*; D009424:Nervous System Physiological Phenomena; D019837:Ryanodine Receptor Calcium Release Channel / Q000378:metabolism
chemical_list: D019837:Ryanodine Receptor Calcium Release Channel; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium