title: Long-term visual outcome in patients with anterior visual pathway gliomas.
abstract: OBJECTIVE
  To investigate the visual outcomes of patients with gliomas of the anterior visual pathway and the clinical features associated with prognosis.
  
  
  METHODS
  During retrospective review, demographic and clinical data were abstracted from medical records of patients seen at the Bascom Palmer Eye Institute between January 1, 1970 and December 31, 1998.
  
  
  RESULTS
  Of the 42 patients identified, 68% were female, and 55% had neurofibromatosis (NF) type I. There was no substantial difference in presenting signs, symptoms, and visual acuity between the NF(+) and NF(-) groups except for nystagmus, which was more common in the NF(-) group (p = 0.014). Throughout follow-up evaluation, vision in the better eye remained stable in both groups, independent of treatment or NF status. Vision in the worse eye often declined, despite treatment. However, binocular visual status, measured as average weighted logMAR (MAR, minimum angle of resolution) vision, did not change significantly over time, regardless of treatment or NF status.
  
  
  CONCLUSIONS
  In the NF(+) and NF(-) groups, vision in the better eye remained stable, regardless of treatment, and vision in the worse eye often declined, despite treatment. Binocular visual acuity (measured as weighted logMAR) did not change significantly over time, regardless of NF status or treatment modality.
authors.affiliation: Bascom Palmer Eye Institute, Department of Ophthalmology,  University of Miami School of Medicine, Florida, USA.
authors.forename: G S
authors.initials: GS
authors.lastname: Gayre
authors.forename: I U
authors.initials: IU
authors.lastname: Scott
authors.forename: W
authors.initials: W
authors.lastname: Feuer
authors.forename: T G
authors.initials: TG
authors.lastname: Saunders
authors.forename: R M
authors.initials: RM
authors.lastname: Siatkowski
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000150:complications / Q000503:physiopathology; D020339:Optic Nerve Glioma / Q000150:complications / Q000503:physiopathology*; D012189:Retrospective Studies; D015348:Vision, Binocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology*; D014795:Visual Pathways / Q000503:physiopathology*