[Role of macrophages in the antitumor action of the recombinant probiotic Subalin].
Course administration of the recombinant probiotic subalin was shown to significantly potentiate the cytotoxic action of macrophages from healthy and tumor-bearing mice against mastocytoma P-815 cells and syngeneic target cells of lung sarcoma of Lewis. Carrageenan, an inhibitor of macrophage activity, significantly cut down the antimetastaic effect of subalin. The crucial role of macrophages in the mechanism of this function of the drug is discussed.
Litviakov
N V
NV
Research Institute of Oncology, Research Center, Russian Academy of Medical Science, Siberian Branch, Tomsk.
Cherdyntseva
N V
NV
Beliavskaia
V A
VA
Malinovskaia
E A
EA
Il'inykh
I S
IS
Smol'ianinov
E S
ES
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D002351:Carrageenan / Q000494:pharmacology; D008264:Macrophages / Q000187:drug effects*; D012515:Mast-Cell Sarcoma / Q000188:drug therapy*; D051379:Mice; D019936:Probiotics / Q000494:pharmacology*; D011994:Recombinant Proteins / Q000494:pharmacology
D001685:Biological Factors; D011994:Recombinant Proteins; C112120:subalin; D002351:Carrageenan