Transferable antibiotic resistance in multiresistant nosocomial Acinetobacter baumannii strains from seven clinics in the Slovak and Czech Republics.
Sixty-seven multiresistant nosocomial Acinetobacter baumannii isolates from patients hospitalized mostly in intensive care units of seven clinics in Slovak and Czech Republic were tested to determine their ability to transfer antibiotic resistance. All isolates were resistant to kanamycin, ticarcillin, cephalothin, cefotaxime, ceftazidime, aztreonam and susceptible to carbapenems, sulbactam and ampicillin/sulbactam. Sixty-five out of 67 strains transferred resistance determinants to Escherichia coli K-12 and Proteus mirabilis P-38 recipients. Analysis of selected transconjugants by an indirect selection method showed a more variable pattern of transferred resistance determinants. The clonal spread of strains transferring resistance seems to be an additional risk for occurrence of strains resistant to ceftazidime and aztreonam.
Blahová
J
J
Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic. blahova@upkm.sk
Králiková
K
K
Krcméry
V
V
Kubonová
K
K
Vaculíková
A
A
Mikovicová
A
A
Klokocníková
L
L
Hanzen
J
J
Jezek
P
P
D000150:Acinetobacter / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D000151:Acinetobacter Infections / Q000188:drug therapy; D003428:Cross Infection / Q000188:drug therapy*; D018153:Czech Republic; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics / Q000472:pathogenicity; D022761:Gene Transfer, Horizontal; D006801:Humans; D007362:Intensive Care Units; D011157:Population Dynamics; D012307:Risk Factors; D018154:Slovakia