The human genome: an immuno-centric view of evolutionary strategies.
A hallmark of modern biology is the realization of the fundamental unity of biological processes in all life forms. Consequently, the complete genome sequencing of various bacteria, yeast (Saccharomyces cerevisiae), fly (Drosophila melanogaster) and worm (Caenorhabditis elegans) over the past five years has already had an impact on all of biology. "Model organisms" have contributed a great deal to immunology; for example, the Toll receptors of the fly provided the impetus for the investigation of Toll-like receptors, which proved to be fundamental elements in the mammalian innate immune system. The recent release of a draft sequence of the human genome provides the first panoramic view of the 30000-35000 human genes in the human genetic blueprint and provides a plethora of new details, the significance of which will take some time to appreciate. The over-riding concepts that emerge from these studies relate primarily to general evolutionary processes that are equally as relevant to immunology as they are to other disciplines of biology.
Liu
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Experimental Immunology Branch, National Cancer Institute, Bethesda, MD 20892, USA.
Shaw
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S
D000595:Amino Acid Sequence; D005075:Biological Evolution; D017124:Conserved Sequence; D019143:Evolution, Molecular; D015894:Genome, Human; D006801:Humans; D007107:Immune System; D017434:Protein Structure, Tertiary