title: A sesquiterpene drimane with antinociceptive activity from Drimys winteri bark.
abstract: Along with three known drimanes, polygodial. 1-beta-(p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive action against acetic acid induced pain, being about 3-fold less active than polygodial.
authors.affiliation: Departamento de Farmacologia, Trindade, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Malheiros
authors.forename: V C
authors.initials: VC
authors.lastname: Filho
authors.forename: C B
authors.initials: CB
authors.lastname: Schmitt
authors.lastname: Santos ARS
authors.forename: C
authors.initials: C
authors.lastname: Scheidt
authors.forename: J B
authors.initials: JB
authors.lastname: Calixto
authors.forename: F D
authors.initials: FD
authors.lastname: Monache
authors.forename: R A
authors.initials: RA
authors.lastname: Yunes
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D000700:Analgesics; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane