title: Bonus, a Drosophila homolog of TIF1 proteins, interacts with nuclear receptors and can inhibit betaFTZ-F1-dependent transcription.
abstract: The Drosophila bonus (bon) gene encodes a homolog of the vertebrate TIF1 transcriptional cofactors. bon is required for male viability, molting, and numerous events in metamorphosis including leg elongation, bristle development, and pigmentation. Most of these processes are associated with genes that have been implicated in the ecdysone pathway, a nuclear hormone receptor pathway required throughout Drosophila development. Bon is associated with sites on the polytene chromosomes and can interact with numerous Drosophila nuclear receptor proteins. Bon binds via an LxxLL motif to the AF-2 activation domain present in the ligand binding domain of betaFTZ-F1 and behaves as a transcriptional inhibitor in vivo.
authors.affiliation: Department of Molecular and Cellular Biology, One Baylor Plaza, Houston, TX 77030, USA.
authors.forename: R
authors.initials: R
authors.lastname: Beckstead
authors.forename: J A
authors.initials: JA
authors.lastname: Ortiz
authors.forename: C
authors.initials: C
authors.lastname: Sanchez
authors.forename: S N
authors.initials: SN
authors.lastname: Prokopenko
authors.forename: P
authors.initials: P
authors.lastname: Chambon
authors.forename: R
authors.initials: R
authors.lastname: Losson
authors.forename: H J
authors.initials: HJ
authors.lastname: Bellen
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins / Q000235:genetics*; D002843:Chromatin / Q000235:genetics / Q000378:metabolism; D017124:Conserved Sequence; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000235:genetics*; D004330:Drosophila / Q000235:genetics*; D029721:Drosophila Proteins; D004440:Ecdysone / Q000235:genetics / Q000378:metabolism; D005656:Fungal Proteins / Q000235:genetics; D051717:Fushi Tarazu Transcription Factors; D018507:Gene Expression Regulation, Developmental; D018398:Homeodomain Proteins; D019476:Insect Proteins; D008675:Metamorphosis, Biological / Q000235:genetics; D016296:Mutagenesis / Q000502:physiology; D018995:Myosin Heavy Chains; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D010641:Phenotype; D017434:Protein Structure, Tertiary; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism*; D012097:Repressor Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D017386:Sequence Homology, Amino Acid; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*; D014158:Transcription, Genetic / Q000502:physiology*; D014714:Vertebrates; D009218:Myosins
chemical_list: D051017:Apoptosis Regulatory Proteins; D002352:Carrier Proteins; D002843:Chromatin; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D004440:Ecdysone; D005656:Fungal Proteins; D051717:Fushi Tarazu Transcription Factors; D018398:Homeodomain Proteins; D019476:Insect Proteins; D018995:Myosin Heavy Chains; D009687:Nuclear Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; C052130:GAL4 protein, S cerevisiae; C407152:MYO18A protein, human; D009218:Myosins; C497169:ftz protein, Drosophila; C499712:nuclear hormone receptor FTZ-F1, Drosophila