Determinants of genital human papillomavirus detection in a US population.
This study investigated the association of selected demographic and behavioral characteristics with the detection of low-risk, high-risk, and uncharacterized genital human papillomavirus (HPV) in women attending clinic for routine nonreferral gynecologic health care. Cervical specimens obtained from 3863 women 18-40 years old (mean, 28 years) with no history of high-grade cervical disease were analyzed for 38 HPV types. Overall, HPV prevalence was 39.2%. The prevalence of high-risk, low-risk, and uncharacterized HPV types was 26.7%, 14.7%, and 13.0%, respectively. As expected, the characteristics most strongly associated with overall HPV detection were age and numbers of lifetime and recent sex partners. Low-risk, high-risk, and uncharacterized HPV detection increased with increasing numbers of sex partners. There was a decline in high-risk and low-risk HPV detection with increasing age but little change in uncharacterized HPV detection. These results suggest that the uncharacterized HPV types have a different natural history than either low-risk or high-risk HPV types.
Peyton
C L
CL
University of New Mexico, Department of Molecular Genetics and Microbiology, Albuquerque, New Mexico 87131-5276, USA.
Gravitt
P E
PE
Hunt
W C
WC
Hundley
R S
RS
Zhao
M
M
Apple
R J
RJ
Wheeler
C M
CM
D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D005831:Genital Diseases, Female / Q000453:epidemiology* / Q000821:virology; D006801:Humans; D008403:Mass Screening / Q000379:methods; D016017:Odds Ratio; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000453:epidemiology* / Q000821:virology; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D012725:Sexual Behavior; D014412:Tumor Virus Infections / Q000453:epidemiology* / Q000821:virology; D014481:United States / Q000453:epidemiology
D004279:DNA, Viral