title: Pressure-regulated volume control vs volume control ventilation in infants after surgery for congenital heart disease.
abstract: The objective of this investigation was to compare how two modes of positive pressure ventilation affect cardiac output, airway pressures, oxygenation, and carbon dioxide removal in children with congenital heart disease in the immediate postoperative period. The investigation used a one group pretest-post-test study design and was performed in the pediatric cardiac intensive care unit in a university-affiliated children's hospital. Nine infants were enrolled immediately after repair of tetralogy of Fallot (2) or atrioventricular septal defects (7) with mean weight = 5.5 kg (4.2-7.3 kg). Children were admitted to the pediatric cardiothoracic intensive care unit after complete surgical repair of their cardiac defect and stabilized on a Siemen's Servo 300 ventilator in volume control mode (VCV1) (volume-targeted ventilation with a square flow wave pattern). Tidal volume was set at 15 cc/kg (total). Hemodynamic parameters, airway pressures and ventilator settings, and an arterial blood gas were measured. Patients were then changed to pressure-regulated volume control mode (PRVC) (volume-targeted ventilation with decelerating flow wave pattern) with the tidal volume set as before. Measurements were repeated after 30 minutes. Patients were then returned to volume control mode (VCV2) and final measurements made after 30 minutes. The measurements and results are as follows: After correction of congenital heart defects in infants, mechanical ventilation using a decelerating flow wave pattern resulted in a 19% decrease in peak inspiratory pressure without affecting hemodynamics, arterial oxygenation, or carbon dioxide removal.
authors.affiliation: Department of Pediatrics and Surgery, University of Southern California School of Medicine, Los Angeles, CA 90027, USA.
authors.forename: K C
authors.initials: KC
authors.lastname: Kocis
authors.forename: M K
authors.initials: MK
authors.lastname: Dekeon
authors.forename: H K
authors.initials: HK
authors.lastname: Rosen
authors.forename: K P
authors.initials: KP
authors.lastname: Bandy
authors.forename: D C
authors.initials: DC
authors.lastname: Crowley
authors.forename: E L
authors.initials: EL
authors.lastname: Bove
authors.forename: T
authors.initials: T
authors.lastname: Kulik
mesh_terms: D000704:Analysis of Variance; D002245:Carbon Dioxide / Q000097:blood; D006344:Heart Septal Defects, Atrial / Q000601:surgery*; D006345:Heart Septal Defects, Ventricular / Q000601:surgery*; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D015278:Intensive Care Units, Pediatric; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011175:Positive-Pressure Respiration / Q000379:methods*; D011182:Postoperative Care; D015656:Respiratory Mechanics; D013771:Tetralogy of Fallot / Q000601:surgery; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen