Could reduced cerebrospinal fluid (csf) galanin contribute to restricted eating in anorexia nervosa?
Galanin (GAL) and gamma amino butyric acid (GABA) are orexigenic neuropeptides that could contribute to the pathogenesis of anorexia nervosa (AN). To avoid the confounding effects of the ill state, we studied women who were recovered (> 1 year, normal weight, and regular menstrual cycles, no binging or purging) from AN (REC AN) and matched healthy control women (NC). CSF GAL was reduced in REC AN (64.4 +/- 8.6 pg/ml) compared to NC (72.0 +/- 11.6 pg/ml; p <.05), GABA was similar between groups. In the brain, GAL stimulates appetite and fat consumption. These data raise the question of whether alterations in brain GAL activity plays a role in clinical symptoms in AN, such as food restriction and fat avoidance.
Frank
G K
GK
Department of Psychiatry, Western Psychiatric Institute and Clinic, University of Pittsburgh, School of Medicine, Pittsburgh, PA 15213, USA.
Kaye
W H
WH
Sahu
A
A
Fernstrom
J
J
McConaha
C
C
D000328:Adult; D000856:Anorexia Nervosa / Q000134:cerebrospinal fluid* / Q000503:physiopathology; D001835:Body Weight / Q000502:physiology; D015536:Down-Regulation / Q000502:physiology; D004435:Eating / Q000502:physiology*; D005260:Female; D019004:Galanin / Q000134:cerebrospinal fluid* / Q000172:deficiency*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D019004:Galanin