title: A randomized clinical trial on the treatment of oral herpes with topical zinc oxide/glycine.
abstract: BACKGROUND
  A zinc preparation that provides a higher concentration of solubilized zinc in a minimally irritating formulation allowing controlled absorption would be of great clinical value for treating oral herpes.
  
  
  OBJECTIVE
  To determine the effect of zinc oxide/glycine cream as a treatment for facial and circumoral herpes infection by measuring duration and intensity of signs and symptoms and assessing adverse effects.
  
  
  METHODS
  Double-blind, placebo-controlled, randomized clinical trial.
  
  
  METHODS
  Subjects were enrolled from the general community through advertisements.
  
  
  METHODS
  Forty-six subjects with facial or circumoral herpes infections.
  
  
  METHODS
  Application of a zinc oxide/glycine cream or a placebo cream every 2 hours until cold sore resolved or 21 days elapsed.
  
  
  METHODS
  Duration of cold sore lesions, severity of signs and symptoms, and frequency of adverse effects.
  
  
  RESULTS
  Subjects who began treatment with a zinc oxide/glycine cream within 24 hours of onset of signs and symptoms experienced a significantly shorter duration of cold sore lesions (mean, 5.0 days) than did subjects treated with a placebo cream (mean, 6.5 days). Subjects treated with the zinc oxide/glycine cream also experienced reduction in overall severity of signs and symptoms, particularly blistering, soreness, itching, and tingling. Side effects among subjects treated with zinc oxide/glycine cream were those expected from an ionic zinc salt solution. All were completely reversible and of short duration.
  
  
  CONCLUSIONS
  Zinc oxide/glycine cream is an effective treatment for facial and circumoral herpes infection with predictable adverse effects that are completely reversible.
authors.affiliation: Allterra, Inc, Huntingdon Valley, Pa., USA.
authors.forename: H R
authors.initials: HR
authors.lastname: Godfrey
authors.forename: N J
authors.initials: NJ
authors.lastname: Godfrey
authors.forename: J C
authors.initials: JC
authors.lastname: Godfrey
authors.forename: D
authors.initials: D
authors.lastname: Riley
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D003879:Dermatologic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005998:Glycine / Q000008:administration & dosage / Q000627:therapeutic use*; D006560:Herpes Labialis / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D015034:Zinc Oxide / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D003879:Dermatologic Agents; D015034:Zinc Oxide; D005998:Glycine