Modeling random effects for censored data by a multivariate normal regression model.
A normal distribution regression model with a frailty-like factor to account for statistical dependence between the observed survival times is introduced. This model, as opposed to standard hazard-based frailty models, has survival times that, conditional on the shared random effect, have an accelerated failure time representation. The dependence properties of this model are discussed and maximum likelihood estimation of the model's parameters is considered. A number of examples are considered to illustrate the approach. The estimated degree of dependence is comparable to other models, but the present approach has the advantage that the interpretation of the random effect is simpler than in the frailty model.
Klein
J P
JP
Division of Biostatistics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. klein@biostat.mcw.edu
Pelz
C
C
Zhang
M J
MJ
D000818:Animals; D001699:Biometry; D003327:Coronary Disease / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015233:Models, Statistical; D015999:Multivariate Analysis; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D012044:Regression Analysis