title: Rap1 signalling: adhering to new models.
abstract: Ras-like GTPases are ubiquitously expressed, evolutionarily conserved molecular switches that couple extracellular signals to various cellular responses. Rap1, the closest relative of Ras, has attracted much attention because of the possibility that it regulates Ras-mediated signalling. Rap1 is activated by extracellular signals through several regulatory proteins, and it might function in diverse processes, ranging from modulation of growth and differentiation to secretion, integrin-mediated cell adhesion and morphogenesis.
authors.affiliation: Department of Physiological Chemistry and Centre for Biomedical Genetics, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands. j.l.bos@med.uu.nl
authors.forename: J L
authors.initials: JL
authors.lastname: Bos
authors.forename: J
authors.initials: J
authors.lastname: de Rooij
authors.forename: K A
authors.initials: KA
authors.lastname: Reedquist
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D015398:Signal Transduction / Q000502:physiology*; D020827:rap1 GTP-Binding Proteins / Q000737:chemistry / Q000502:physiology*
chemical_list: D020827:rap1 GTP-Binding Proteins