Extrinsic allergic alveolitis from a proteolytic enzyme.
BACKGROUND
Subtilisins are proteolytic enzymes of bacterial origin found in detergents. They are high-molecular-weight antigens and have been implicated in allergic rhinitis and asthma.


OBJECTIVE
This report describes a case of extrinsic allergic alveolitis due to subtilisins in a liquid cleaner.


METHODS
Clinical, radiologic, and serologic information were used to make the diagnosis.


METHODS
A 53-year-old woman developed respiratory symptoms while working with a cleaner containing subtilisins. Her symptoms intensified in the work environment and improved away from work. A computed tomography scan demonstrated alveolar and interstitial infiltrates with subsequent scarring. A pulmonary function study revealed a restrictive pattern with diminished diffusion capacity. Bronchoalveolar lavage showed lymphocytosis and all cultures were negative. Precipitating antibodies to the enzyme were found in the patient's serum. Her symptoms improved once she changed her occupation.


CONCLUSIONS
The combination of the patient's clinical history, physical, laboratory, and radiologic findings support the diagnosis of extrinsic allergic alveolitis from the enzyme contained in the cleaner.
Tripathi
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Ernest S. Bazley Asthma and Allergic Diseases Center, Department of Medicine of Northwestern Memorial Hopsital and Northwestern University Medical School, Chicago, IL, USA. a-tripathi@nmw.edu
Grammer
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LC
D000542:Alveolitis, Extrinsic Allergic / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology*; D000907:Antibodies, Bacterial / Q000276:immunology; D001412:Bacillus subtilis / Q000201:enzymology / Q000276:immunology; D003902:Detergents / Q000737:chemistry; D005260:Female; D016908:Gram-Positive Bacterial Infections / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology*; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging; D008875:Middle Aged; D009784:Occupational Diseases / Q000000981:diagnostic imaging / Q000276:immunology / Q000382:microbiology*; D011233:Precipitin Tests; D012123:Pulmonary Ventilation; D013381:Subtilisins / Q000276:immunology*; D014057:Tomography, X-Ray Computed
D000907:Antibodies, Bacterial; D003902:Detergents; D013381:Subtilisins