title: Simultaneous measurement of regional cerebral blood flow by perfusion CT and stable xenon CT: a validation study.
abstract: OBJECTIVE
  Knowledge of cerebral blood flow (CBF) alterations in cases of acute stroke could be valuable in the early management of these cases. Among imaging techniques affording evaluation of cerebral perfusion, perfusion CT studies involve sequential acquisition of cerebral CT sections obtained in an axial mode during the IV administration of iodinated contrast material. They are thus very easy to perform in emergency settings. Perfusion CT values of CBF have proved to be accurate in animals, and perfusion CT affords plausible values in humans. The purpose of this study was to validate perfusion CT studies of CBF by comparison with the results provided by stable xenon CT, which have been reported to be accurate, and to evaluate acquisition and processing modalities of CT data, notably the possible deconvolution methods and the selection of the reference artery.
  
  
  METHODS
  Twelve stable xenon CT and perfusion CT cerebral examinations were performed within an interval of a few minutes in patients with various cerebrovascular diseases. CBF maps were obtained from perfusion CT data by deconvolution using singular value decomposition and least mean square methods. The CBF were compared with the stable xenon CT results in multiple regions of interest through linear regression analysis and bilateral t tests for matched variables.
  
  
  RESULTS
  Linear regression analysis showed good correlation between perfusion CT and stable xenon CT CBF values (singular value decomposition method: R(2) = 0.79, slope = 0.87; least mean square method: R(2) = 0.67, slope = 0.83). Bilateral t tests for matched variables did not identify a significant difference between the two imaging methods (P >.1). Both deconvolution methods were equivalent (P >.1). The choice of the reference artery is a major concern and has a strong influence on the final perfusion CT CBF map.
  
  
  CONCLUSIONS
  Perfusion CT studies of CBF achieved with adequate acquisition parameters and processing lead to accurate and reliable results.
authors.affiliation: Department of Diagnostic and Interventional Radiology, University Hospital, Swiss Federal Institute of Technology, CHUV-BH10, 1011 Lausanne, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Wintermark
authors.forename: J P
authors.initials: JP
authors.lastname: Thiran
authors.forename: P
authors.initials: P
authors.lastname: Maeder
authors.forename: P
authors.initials: P
authors.lastname: Schnyder
authors.forename: R
authors.initials: R
authors.lastname: Meuli
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000503:physiopathology; D004660:Encephalitis / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards*; D014978:Xenon
chemical_list: D014978:Xenon