Structure-activity correlation between natural glutathione peroxidase (GPx) and mimics: a biomimetic concept for the design and synthesis of more efficient GPx mimics.
Among the organoselenium compounds that mimic the action of the natural enzyme glutathione peroxidase (GPx), there are certain basic differences in the activity, substrate specificity and mechanism. These differences arise mainly from the nature of the substituents near the reaction center, and stability and reactivity of the intermediates. As an attempt to draw some general concepts for the development of new mimics, a structure - activity correlation between natural GPx and some existing mimics is described.
Mugesh
G
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Institut für Anorganische und Analytische Chemie Technische Universität, Braunschweig, Germany. w.du-mont@tu-bs.de
du Mont
W W
WW
D001665:Binding Sites; D005978:Glutathione / Q000737:chemistry; D005979:Glutathione Peroxidase / Q000737:chemistry*; D018716:Molecular Mimicry; D016566:Organoselenium Compounds / Q000737:chemistry*; D010084:Oxidation-Reduction; D012643:Selenium / Q000737:chemistry; D013329:Structure-Activity Relationship
D016566:Organoselenium Compounds; D005979:Glutathione Peroxidase; D005978:Glutathione; D012643:Selenium