title: Prognostic factors in node-negative squamous cell carcinoma of the thoracic esophagus.
abstract: BACKGROUND
  Among several clinicopathological factors influencing the outcome of patients with esophageal carcinoma, the presence or absence of lymph node metastasis is the most important. Prognostic indicators, however, in patients without lymph node involvement have not been fully understood.
  
  
  METHODS
  Out of 247 patients with primary squamous cell carcinoma of the thoracic esophagus between February 1981 and December 1998, 154 patients (62.3%) underwent esophagectomy with curative intent; 78 patients (50.6%) had no lymph node metastasis. Clinicopathological characteristics of those node-negative 78 patients were investigated.
  
  
  RESULTS
  Pathological tumor stages (pT) were pT1 in 44 patients, pT2 in 24 patients, pT3 in 9 patients, and pT4 in one patient. Forty-six patients are alive free of cancer and another one with pT2N0 tumor is alive with recurrence. Four patients died of recurrence; one in pT1 and three in pT3. The remaining 27 patients died of miscellaneous causes other than esophageal cancer. The 1-, 3-, 5-, and 10-year overall survival rates of all 78 patients including in-hospital mortality were 86.3%, 73%, 66.5%, and 34.6%, respectively. The 3- and 5-year survival rates were 75.4% and 67.7% for those with pT1, T2 tumor (n = 68) and 57.1% and 57.1% for those with pT3, T4 tumor (n = 10) (p = 0.0151). The factors influencing overall survival rate were patient age (< 65 vs. > or = 65), depth of invasion (pT1,T2 vs. pT3, T4), time of operation (< or = 420 min vs. > 420 min), and estimated blood loss (< or = 810 ml vs. > 810 ml). More elderly patients died of unrelated causes to esophageal cancer than younger patients. Among those four variables, the patient age (p = 0.0114) and depth of invasion (p = 0.0443) were independent prognosticators for survival determined by multivariate analysis.
  
  
  CONCLUSIONS
  For follow-up of elderly patients with node-negative esophageal cancer, evaluation of medical problems is more important than detection of recurrence. pT2N0 stage tumors should be considered a group with an excellent prognosis like pT1N0 tumors.
authors.affiliation: Second Department of Surgery, Shimane Medical University, Izumo, Japan. nigeka35@shimane-med.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Tachibana
authors.forename: S
authors.initials: S
authors.lastname: Kinugasa
authors.forename: D K
authors.initials: DK
authors.lastname: Dhar
authors.forename: M
authors.initials: M
authors.lastname: Shibakita
authors.forename: S
authors.initials: S
authors.lastname: Ohno
authors.forename: R
authors.initials: R
authors.lastname: Masunaga
authors.forename: T
authors.initials: T
authors.lastname: Kotoh
authors.forename: H
authors.initials: H
authors.lastname: Kubota
authors.forename: N
authors.initials: N
authors.lastname: Nagasue
mesh_terms: D000368:Aged; D000375:Aging / Q000502:physiology; D002294:Carcinoma, Squamous Cell / Q000401:mortality / Q000473:pathology*; D004938:Esophageal Neoplasms / Q000401:mortality / Q000473:pathology*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D016019:Survival Analysis; D013909:Thorax