title: Hypercalcemia as the presenting feature of t-cell lymphoid blast crisis of ph-positive chronic myeloid leukemia.
abstract: Hypercalcemia is a rare complication of chronic myeloid leukemia (CML), usually seen in the accelerated or blastic phases of the disease and associated with a poor prognosis. T-cell lymphoid phenotype is also an infrequent finding in the blast crisis (BC) of CML. A CML patient who had hypercalcemia as the presenting feature of a T-cell BC is reported. She was a 78 year-old woman who, at four months of CML diagnosis, developed weakness, bone pain, and mental confusion, with hypercalcemia being subsequently found. Although the peripheral blood and bone marrow were consistent with the chronic phase of CML, mediastinal enlargement, a soft tissue mass adjacent to the iliac bone, and multiple osteolytic lesions were seen. Serum levels of parathyroid hormone (PTH) and PTH-related peptide were normal, whereas the search for a second neoplasm was negative. The hypercalcemia initially responded to conventional treatment, but it reappeared two weeks later. Coincidentally, a high proportion of blast cells of T-cell origin at the cortical thymocyte stage were observed in the patient's peripheral blood and bone marrow, and she died shortly afterwards.
authors.affiliation: Institute of Hematology and Oncology, Hematology Department, Postgraduate School of Hematology Farreras Valentí, IDIBAPS, Hospital Clinic, University of Barcelona, Spain, Villarroel 170, 08036 Barcelona, Spain. cervante@medicina.ub.es
authors.forename: E
authors.initials: E
authors.lastname: Nadal
authors.forename: F
authors.initials: F
authors.lastname: Cervantes
authors.forename: L
authors.initials: L
authors.lastname: Rosiñol
authors.forename: C
authors.initials: C
authors.lastname: Talarn
authors.forename: E
authors.initials: E
authors.lastname: Montserrat
mesh_terms: D000368:Aged; D001752:Blast Crisis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*