[Clinico-immunological variants of the course of chronic pancreatitis].
OBJECTIVE
To study relationships between clinical course of chronic pancreatitis (CP) and humoral immunity in CP patients.


METHODS
Humoral immunity to structural and secretory pancreatic components and some phlogogenic factors of humoral and cellular origin as well as distribution of HLA antigens were studied in 115 CP patients.


RESULTS
Two variants of CP course were identified: immunologically dependent and immunologically independent. These variants have typical clinical, laboratory, immunological and immunogenetic differences.


CONCLUSIONS
Identification of immunologically dependent variant of CP has both fundamental and practical value as it enables more precise prognosis of the disease clinical course and differential approach to its treatment.
Trukhan
D I
DI
D000936:Antigen-Antibody Complex / Q000032:analysis*; D002908:Chronic Disease; D003165:Complement System Proteins / Q000032:analysis*; D003937:Diagnosis, Differential; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D005779:Immunodiffusion; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D010195:Pancreatitis / Q000175:diagnosis / Q000276:immunology*; D019512:Pancreatitis, Alcoholic / Q000175:diagnosis / Q000276:immunology; D010783:Photometry; D011379:Prognosis
D000936:Antigen-Antibody Complex; D006680:HLA Antigens; D007136:Immunoglobulins; D003165:Complement System Proteins