title: Predicting adaptive evolution.
abstract: Phylogenetic trees reconstruct past evolution and can provide evidence of past evolutionary pressure on genes and on individual codons. In addition to tracing past evolutionary events, molecular phylogenetics might also be used to predict future evolution. Our ability to verify adaptive hypotheses using phylogenetics has broad implications for vaccine design, genomics and structural biology.
authors.forename: R M
authors.initials: RM
authors.lastname: Bush
mesh_terms: D000220:Adaptation, Biological / Q000235:genetics*; D000818:Animals; D000939:Epitopes / Q000276:immunology; D019143:Evolution, Molecular; D018745:Genome, Plant; D006801:Humans; D010802:Phylogeny; D011487:Protein Conformation; D014612:Vaccines
chemical_list: D000939:Epitopes; D014612:Vaccines