Effect of acute alcohol administration on cerebral tyrosine hydroxylase mRNA level in mice with different ethanol sensitivity.
The levels of tyrosine hydroxylase mRNA in different brain regions of inbred mice with different sensitivity to alcohol were evaluated. This parameter was also measured 2, 4, and 6 h after single intraperitoneal injection of ethanol. We revealed interstrain differences in expression of tyrosine hydroxylase gene in the cerebral cortex, hypothalamus, and locus ceruleus. Single ethanol injection caused different changes in tyrosine hydroxylase gene expression and reduced the interstrain differences. We conclude that the system of long-term regulation of tyrosine hydroxylase gene is involved in the mechanisms of congenital alcohol sensitivity.
Kibitov
A O
AO
Laboratory of Psychopharmacology, Institute of Narcology, Ministry of Health of the Russian Federation, Moscow. ria@postman.ru
Anokhina
I P
IP
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D005786:Gene Expression Regulation / Q000235:genetics; D007031:Hypothalamus / Q000378:metabolism; D008125:Locus Coeruleus / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics* / Q000378:metabolism
D012333:RNA, Messenger; D000431:Ethanol; D014446:Tyrosine 3-Monooxygenase