[Glucose-6-phosphate dehydrogenase et neonatal jaundice].
OBJECTIVE
Since 1986, quantification of G6PD activity has been a routine test for all babies born at the public maternity hospitals of Marseilles. The objective of our study was to determine the prevalence of G6PD deficiency in the population tested and to evaluate the relative risk of neonatal jaundice in newborns with G6PD deficiency.


METHODS
Neonatal screening is performed on cord blood by spectrophotometric measurements of G6PD activity. A group of 7779 newborns was studied retrospectively. The occurrence of neonatal jaundice was evaluated in 85 children with G6PD deficiency and compared to 85 children with normal G6PD activity.


RESULTS
The incidence of G6PD deficiency in male newborns was found to be 2.1%. The relative risk for neonatal jaundice in the G6PD deficient population compared to the non-deficient population is estimated to be 2.6.


CONCLUSIONS
Neonatal jaundice with pathological hyperbilirubinemia develops more frequently in cases of G6PD deficiency. The early characterization of G6PD activity provides an etiological diagnosis for neonatal jaundice, as well as the opportunity to give the newborn's family information concerning hemolytic crisis prevention.
Badens
C
C
Laboratoire des Hémoglobines, Centre d'Enseignement et de Recherche en Génétique Médicale, Faculté de Médecine de la Timone, Marseille. badens@medecine.univ-mrs.fr
Leclaire
M
M
Collomb
J
J
Auquier
P
P
Soyer
P
P
Michel
G
G
Mattei
J F
JF
Lena-Russo
D
D
D015331:Cohort Studies; D005260:Female; D005602:France / Q000453:epidemiology; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000150:complications / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D008297:Male; D015997:Neonatal Screening; D010789:Phototherapy; D015995:Prevalence; D012189:Retrospective Studies; D012306:Risk; D012737:Sex Factors; D013053:Spectrophotometry
D005954:Glucosephosphate Dehydrogenase