title: Efficacy of an intravaginal progesterone insert and an injection of PGF2alpha for synchronizing estrus and shortening the interval to pregnancy in postpartum beef cows, peripubertal beef heifers, and dairy heifers.
abstract: The objective was to test the efficacy of an intravaginal progesterone insert and injection of PGF2alpha for synchronizing estrus and shortening the interval to pregnancy in cattle. Cattle were assigned to one of three treatments before a 31-d breeding period that employed artificial insemination. Control cattle were not treated, and treated cattle were administered PGF2alpha or an intravaginal progesterone-releasing insert (CIDR) for 7 d and treated with PGF2alpha on d 6. The treatments were applied in one of three experiments that involved postpartum beef cows (Exp. 1; n = 851; 56+/-0.6 d postpartum), beef heifers (Exp. 2; n = 724; 442.5+/-2.8 d of age), and dairy heifers (Exp. 3; n = 260; 443.2+/-4.5 d of age). Luteal activity before treatment was determined for individual cattle based on blood progesterone concentrations. In Exp. 1, there was a greater incidence of estrus during the first 3 d of the breeding period in CIDR+PGF2alpha-treated cows compared with PGF2alpha-treated or control cows (15, 33, and 59% for control, PGF2alpha, and CIDR+PGF2alpha, respectively; P < 0.001). The improved estrous response led to an increase in pregnancy rate during the 3-d period (7, 22, and 36% for control, PGF2alpha, and CIDR+PGF2alpha, respectively; P < 0.001) and tended to improve pregnancy rate for the 31-d breeding period for cows treated with CIDR+PGF2alpha, (50, 55, and 58% for control, PGF2alpha, and CIDR+PGF2alpha, respectively, P = 0.10). Improvements in rates of estrus and pregnancy after CIDR+PGF2alpha, were also observed in beef heifers. Presence of luteal activity before the treatment period affected synchronization and pregnancy rates because anestrous cows (Exp. 1) or prepubertal heifers (Exp. 2) had lesser synchronization rates and pregnancy rates during the first 3 d of the breeding period as well as during the entire 31-d breeding period. The PGF2alpha, and CIDR+PGF2alpha but not the control treatments were evaluated in dairy heifers (Exp. 3). The CIDR+PGF2alpha-treated heifers had a greater incidence of estrus (84%) during the first 3 d of the breeding period compared with the PGF2alpha-treated heifers (57%), but pregnancy rates during the first 3 d or during the 31-d breeding period were not improved for CIDR+PGF2alpha compared with PGF2alpha-treated heifers. In summary, the concurrent treatment of CIDR and PGF2alpha improved synchronization rates relative to PGF2alpha alone or control. Improved estrus synchrony led to greater pregnancy rates for beef cows and beef heifers but failed to improve pregnancy rates for dairy heifers.
authors.affiliation: Department of Animal Science, University of Missouri, Columbia 65211, USA. lucym@missouri.edu
authors.forename: M C
authors.initials: MC
authors.lastname: Lucy
authors.forename: H J
authors.initials: HJ
authors.lastname: Billings
authors.forename: W R
authors.initials: WR
authors.lastname: Butler
authors.forename: L R
authors.initials: LR
authors.lastname: Ehnis
authors.forename: M J
authors.initials: MJ
authors.lastname: Fields
authors.forename: D J
authors.initials: DJ
authors.lastname: Kesler
authors.forename: J E
authors.initials: JE
authors.lastname: Kinder
authors.forename: R C
authors.initials: RC
authors.lastname: Mattos
authors.forename: R E
authors.initials: RE
authors.lastname: Short
authors.forename: W W
authors.initials: WW
authors.lastname: Thatcher
authors.forename: R P
authors.initials: RP
authors.lastname: Wettemann
authors.forename: J V
authors.initials: JV
authors.lastname: Yelich
authors.forename: H D
authors.initials: HD
authors.lastname: Hafs
mesh_terms: D000282:Administration, Intravaginal; D000818:Animals; D002417:Cattle / Q000502:physiology*; D003612:Dairying; D015237:Dinoprost / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D004973:Estrus Synchronization / Q000187:drug effects*; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D049590:Postpartum Period; D011247:Pregnancy; D018873:Pregnancy Rate; D011374:Progesterone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D011374:Progesterone; D015237:Dinoprost