Vaccination of a refractory essential monoclonal cryoglobulinemia patient with cryoglobulin-pulsed dendritic cells.
We vaccinated a refractory essential monoclonal cryoglobulinemia patient with monocyte-derived DCs (Mo-DCs) pulsed with purified cryoglobulin as a tumor antigen. During the vaccinations, his acrocyanosis improved and we were able to reduce the number of hot baths used to treat his symptoms, with no side effects. Furthermore, cryoglobulin-specific proliferative responses were observed after the vaccination. As there was a recurrence of acrocyanosis after the final vaccination, vaccination with Mo-DCs pulsed with purified cryoglobulin would seem to be a useful treatment for refractory essential monoclonal cryoglobulinemia.
Maeda
M
M
Blood Transfusion Service, Kyushu University Hospital Fukuoka, Japan. maedacc@cancer.med.kyushu-u.ac.jp
Inaba
S
S
Nomura
A
A
Tokunaga
Y
Y
Sugio
Y
Y
Itoh
Y
Y
Iino
T
T
Otsuka
T
T
Okamura
S
S
Niho
Y
Y
D000941:Antigens; D002999:Clone Cells / Q000473:pathology; D003449:Cryoglobulinemia / Q000473:pathology / Q000628:therapy*; D003450:Cryoglobulins / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology / Q000637:transplantation*; D006801:Humans; D016219:Immunotherapy, Adoptive / Q000379:methods*; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D008875:Middle Aged; D014611:Vaccination
D000941:Antigens; D003450:Cryoglobulins