Reversible decrease of dopamine D2 receptor density in the striatum of rats with acute hepatic failure.
The binding of a D2 receptor ligand, [3H]spiperone, was measured in striatal membranes derived from rats in which acute hepatic failure induced with thioacetamide (TAA) was associated with symptoms of hepatic encephalopathy (HE), and during recovery from HE. A 28% decrease of Bmax for the binding was measured in a symptomatic stage of HE, 1 day after TAA administration. The B(max) for [3H]spiperone binding was no longer different from control 7 days after TAA administration, when blood and brain biochemical correlates of HE were already absent. At 21 days after TAA administration, the B(max) was increased by 31% above the control level, consistent with other aspects of metabolic activation of the brain characteristic of the late recovery period from acute HE.
Waśkiewicz
J
J
Laboratory of CNS Pathobiochemistry, Department of Neurochemistry, Medical Research Centre, Polish Academy of Sciences, Pawinskiego 5, 02-106, Warsaw, Poland.
Freśko
I
I
Lenkiewicz
A
A
Albrecht
J
J
D000208:Acute Disease; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000378:metabolism; D015536:Down-Regulation; D006501:Hepatic Encephalopathy / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism; D013853:Thioacetamide / Q000633:toxicity
D018492:Dopamine Antagonists; D017448:Receptors, Dopamine D2; D013853:Thioacetamide; D013134:Spiperone