Rotavirus encephalopathy: pathogenesis reviewed.
Two cases of rotavirus gastroenteritis associated with neurological involvement, one with encephalitis (defined by abnormal neurological signs, cerebrospinal fluid (CSF) pleocytosis and detection of rotavirus genomic nucleic acid in the CSF) and one with a non-inflammatory encephalopathy (defined by abnormal neurological signs, an entirely normal CSF and detection of rotavirus genomic nucleic acid in the CSF), are presented and used as a basis to review and explore potential pathogenetic mechanisms, including direct viral replication within neurons and indirect effects of the newly described rotavirus 'enterotoxin'.
Goldwater
P N
PN
The Women's and Children's Hospital, North Adelaide, Australia. goldwaterp@mail.wch.sa.gov.au
Rowland
K
K
Thesinger
M
M
Abbott
K
K
Grieve
A
A
Palombo
E A
EA
Masendycz
P J
PJ
Wilkinson
I
I
Bear
J
J
D000212:Acyclovir / Q000627:therapeutic use; D000998:Antiviral Agents / Q000627:therapeutic use; D001315:Australia; D002439:Cefotaxime / Q000627:therapeutic use; D002494:Central Nervous System Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*; D002511:Cephalosporins / Q000627:therapeutic use; D002675:Child, Preschool; D004569:Electroencephalography; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D012313:RNA / Q000134:cerebrospinal fluid; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012400:Rotavirus Infections / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology*
D000998:Antiviral Agents; D002511:Cephalosporins; D012313:RNA; D002439:Cefotaxime; D000212:Acyclovir