Serum response of hepatocyte growth factor, insulin-like growth factor-I, interleukin-6, and acute phase proteins in patients with colorectal liver metastases treated with partial hepatectomy or cryosurgery.
OBJECTIVE
The aim of the study was to compare the serum response of regeneration factors and acute phase proteins in patients treated with partial hepatectomy or cryosurgery.


METHODS
The responses of serum hepatocyte growth factor (HGF), insulin-like growth factor-I (IGF-I) (free and total), interleukin-6 (IL-6) and the acute phase proteins, C-reactive protein (CRP) and serum amyloid A (SAA) were examined in patients with colorectal liver metastases treated with partial hepatectomy (n = 14) or cryosurgery (n = 10).


RESULTS
In both groups, IL-6 peak levels at the end of the operation were followed by peak levels at day 1 for HGF and CRP. SAA peak levels occurred on day 1 (hepatectomy group) and on day 4 (cryo group). The total HGF, IGF-I, and IL-6 responses were comparable in both groups. CRP and SAA responses were higher in the patients treated with cryosurgery than in patients after hepatectomy. Free IGF-I trough levels were lower in partial hepatectomy patients than in cryosurgery patients.


CONCLUSIONS
In patients with colorectal liver metastases the responses of the regenerating factors HGF, IGF-I, and IL-6 are comparable to those in patients treated with partial hepatectomy. Upregulation of acute phase protein production is higher in patients after cryosurgery than in patients after partial hepatectomy.
de Jong
K P
KP
Department of Surgery, University Hospital and Medical Faculty of the University of Groningen, The Netherlands. k.p.de.jong@chir.azg.nl
von Geusau
B A
BA
Rottier
C A
CA
Bijzet
J
J
Limburg
P C
PC
de Vries
E G
EG
Fidler
V
V
Slooff
M J
MJ
D000209:Acute-Phase Proteins / Q000378:metabolism*; D000368:Aged; D015179:Colorectal Neoplasms / Q000473:pathology*; D003452:Cryosurgery; D005260:Female; D006133:Growth Substances / Q000097:blood*; D006498:Hepatectomy / Q000379:methods*; D017228:Hepatocyte Growth Factor / Q000097:blood; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D015850:Interleukin-6 / Q000097:blood; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D008875:Middle Aged
D000209:Acute-Phase Proteins; D006133:Growth Substances; D015850:Interleukin-6; D017228:Hepatocyte Growth Factor; D007334:Insulin-Like Growth Factor I