Effect of low levels of dietary tyrosine on the hair colour of cats.
Experiments were conducted to investigate the basis for the change in hair colour of black cats to reddish-brown. Black cats were given purified diets based on gelatin, casein plus lactalbumin, or crystalline amino acids as protein sources. Diets that caused the colour of hair to change to reddish-brown were associated with a reduction in melanin in hair (observed by direct microscopic examination), a decreased total melanin concentration and low concentrations of tyrosine in plasma. Reddish hair coat was induced in black kittens born to queens given a tyrosine-deficient diet during pregnancy. Black hair colour was maintained or restored by diets containing a high concentration of tyrosine or phenylalanine. Current dietary recommendations for dietary tyrosine and phenylalanine for cats are below those required to support maximal melanin synthesis in black cats. The requirement appears to be greater than a combination of 4.5 g tyrosine plus 12 g phenylalanine/kg diet but less than 24 g phenylalanine alone/kg diet.
Yu
S
S
Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis 95616, USA.
Rogers
Q R
QR
Morris
J G
JG
D000596:Amino Acids / Q000097:blood / Q000378:metabolism; D000821:Animal Feed; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D002364:Caseins / Q000008:administration & dosage; D002415:Cats / Q000254:growth & development / Q000502:physiology*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005780:Gelatin / Q000008:administration & dosage; D006200:Hair Color / Q000187:drug effects*; D007768:Lactalbumin / Q000008:administration & dosage; D008543:Melanins / Q000096:biosynthesis / Q000502:physiology*; D009751:Nutritional Requirements; D010649:Phenylalanine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology; D011506:Proteins; D013047:Specific Pathogen-Free Organisms; D014443:Tyrosine / Q000008:administration & dosage / Q000172:deficiency / Q000494:pharmacology*
D000596:Amino Acids; D002364:Caseins; D004044:Dietary Proteins; D008543:Melanins; D011506:Proteins; D014443:Tyrosine; D010649:Phenylalanine; D005780:Gelatin; D007768:Lactalbumin