title: Thrombolytic therapy in an adolescent ischemic stroke.
abstract: We report the case of a 16-year-old Caucasian girl who developed acute onset of left hemiplegia, left hemisensory deficit, and dysarthria. After a negative computed tomographic scan of the brain, the patient was given intravenous recombinant tissue plasminogen activator according to established adult guidelines. The patient experienced a marked improvement within 24 hours. Stroke etiology was determined to be a paradoxical embolus via a patent foramen ovale associated with pelvic vein thrombosis. This case illustrates the importance of early recognition of stroke and the utility of thrombolytics in treating ischemic infarcts in the adolescent population.
authors.affiliation: Department of Neurology, University of Texas-Houston Medical School, 77030-1501, USA. Elizabeth.a.Noser@UTH.TMC.EDU
authors.forename: E A
authors.initials: EA
authors.lastname: Noser
authors.forename: R A
authors.initials: RA
authors.lastname: Felberg
authors.forename: A V
authors.initials: AV
authors.lastname: Alexandrov
mesh_terms: D000293:Adolescent; D002545:Brain Ischemia / Q000188:drug therapy*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007262:Infusions, Intravenous; D020521:Stroke / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000494:pharmacology*; D016896:Treatment Outcome; D020246:Venous Thrombosis
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator