title: Expression of Irx6 during mouse morphogenesis.
abstract: Iroquois (Irx) proteins comprise a family of homeodomain-containing transcription factors involved in patterning and regionalization of embryonic tissues in both vertebrates and invertebrates. The six murine Irx genes are organized in two clusters, each consisting of three genes. Irx1, Irx2 and Irx4 belong to the IrxA cluster on chromosome 13, whereas Irx3, Irx5 and Irx6, comprising the IrxB cluster, are located on chromosome 8 (Peters et al., Genome Res. 10 (2000) 1453). Developmental expression patterns have so far only been reported for five Irx genes. Here, we investigated the expression pattern of Irx6 during mouse morphogenesis and early organogenesis. The pattern was found to be much more restricted compared to the other five Irx genes, and its level of expression was much lower.
authors.affiliation: Institut für Entwicklungs- und Molekularbiologie der Tiere (EMT), Heinrich-Heine-Universität, 40225 Düsseldorf, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Mummenhoff
authors.forename: A C
authors.initials: AC
authors.lastname: Houweling
authors.forename: T
authors.initials: T
authors.lastname: Peters
authors.forename: V M
authors.initials: VM
authors.lastname: Christoffels
authors.forename: U
authors.initials: U
authors.lastname: Rüther
mesh_terms: D000818:Animals; D005121:Extremities / Q000196:embryology; D005123:Eye / Q000196:embryology; D006321:Heart / Q000196:embryology; D018398:Homeodomain Proteins / Q000096:biosynthesis*; D017403:In Situ Hybridization; D051379:Mice; D005810:Multigene Family; D009432:Neural Crest / Q000196:embryology; D013997:Time Factors; D014018:Tissue Distribution; D014157:Transcription Factors / Q000096:biosynthesis*
chemical_list: D018398:Homeodomain Proteins; C501592:Irx1 protein, mouse; C501596:Irx2 protein, mouse; C501599:Irx3 protein, mouse; C501601:Irx5 protein, mouse; C501605:Irx6 protein, mouse; D014157:Transcription Factors