[Proteinkinase B/Akt].
Proteinkinase B/Akt, which was identified in 1991, is a serine/threonine kinase that becomes activated at two residues, Thr308 and Ser473. Activated proteinkinase B/Akt activates glycogen synthesis, protein synthesis, and most important, the survival and proliferation of cells. It was recently reported that mutant preseniline-1 downregulates proteinkinase B/Akt and that lithium treatment changes proteinkinase B/Akt activity. Proteinkinase B/Akt thus seems important from a psychiatric point of view.
Kubota
M
M
Department of Neuropsychiatry, Yamanashi Medical University, Shimogato 1110, Tamaho, Yamanashi, 409-3898 Japan.
D000375:Aging / Q000502:physiology; D000818:Animals; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism / Q000502:physiology*
D017346:Protein Serine-Threonine Kinases