[Effects of an extract of salviae miltiorrhizae (764-3) on structural remodeling of intra-acinar pulmonary artery in pulmonary hypertension due to chronic hypoxia and monocrotaline in rats].
OBJECTIVE
To investigate the effects of an extract of salviae miltiorrhizae (764-3) on the percentage of intra-acinar muscular artery (MA), partal MA(PMA) and nonmuscular MA(NMA) and collagen deposition in the media of MA in rats with hypoxia and MCT-induced pulmonary hypertension.


METHODS
Wistar rats were divided into 12 groups. The hypobaric hypoxic 51 kPa (1 kPa = 7.5 mmHg) and MCT (60 mg/kg intraperitoneal injection) rats were treated with 764-3 (20 mg/kg), beta-aminopropionitrile (BAPN, 150 mg/kg) and 764-3 (40 mg/kg), respectively. At each time point, the hemodynamic and morphological parameters were measured.


RESULTS
After hypoxia for 2 weeks, the percentage of MA increased (P < 0.001), of NMA decreased (P < 0.001) and of PMA no obvious change; and after 4 weeks, the above changes became to be more striking and the collagen content in the media of MA increased (P < 0.001). The MCT-treated rats had more severe changes than the hypoxic rats. Both 764-3 and BAPN could inhibit the changes, decreased the collagen content and BAPN was more effective than 764-3(P < 0.05).


CONCLUSIONS
764-3 can partially inhibit collagen deposition in pulmonary arterioles attenuate hypoxia and MCT-induced pulmonary hypertension, reduce the percentage of MA, and has a moderate influence on collagen deposition as compared with BAPN.
Liu
Z
Z
Cardiovascular Institute and Fu Wai Hospital, CAMS and PUMC, Beijing 100037.
Cheng
X
X
Cai
R
R
D000818:Animals; D003094:Collagen / Q000378:metabolism; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000209:etiology / Q000473:pathology*; D000860:Hypoxia / Q000150:complications; D008297:Male; D016686:Monocrotaline; D011650:Pulmonary Alveoli / Q000098:blood supply; D011651:Pulmonary Artery / Q000378:metabolism / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; C079053:IH 764-3; D016686:Monocrotaline; D003094:Collagen