[Cytokines production by immune system cells in patients with various forms of chronic rhinosinusitis].
Production of cytokines IL-1 beta, IL-8, TNF-alpha, IFN-alpha and IFN-gamma by blood cells and their level in paranasal sinus lavage fluid (LF) were studied in seventy two patients with chronic rhinosinusitis. It was found that in various forms of rhinosinusitis the production of proinflammatory cytokines is characterized by common features: IL-1 beta:IL-8:TNF-alpha averages 1:6.5:0.47. While in polypous rhinosinusitis synthesis of IFN-gamma was reduced. LF cytokine profile depends on the form of chronic rhinosinusitis. The polypous form, pyoinflammation, pyopolypous form are characterized by low concentration of TNF-alpha, lack of IL-1 beta, low production of IL-1 beta and interferons alpha and gamma, respectively.
Aznabaeva
L F
LF
Aref'eva
A N
AN
Salakhov
A Kh
AKh
D002908:Chronic Disease; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000502:physiology; D017817:Nasal Lavage Fluid / Q000276:immunology; D012720:Severity of Illness Index; D012852:Sinusitis / Q000175:diagnosis / Q000276:immunology*
D016207:Cytokines