Immune reconstitution after hematopoietic stem cell transplantation: gaining experience without losing naivety.
In addition to lymphocyte phenotyping and functional assays, new tools are now available to monitor specific aspects of the immune response in the follow-up of hematopoietic stem cell transplantation: reconstitution of T-cell diversity (spectratyping or immunoscope), ex vivo thymic function by measuring "T-cell receptor rearrangement excision DNA circles" and antigen-specific T-cell responses (HLA tetramers). Combining these methods should contribute to improve our current knowledge of how the immune system is reconstituted in different settings of hematopoietic stem cell transplantation and how we could improve this recovery process.
Toubert
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Laboratoire d'Immunologie et d'Histocompatibilité, INSERM U. 396, Institut Universitaire d'Hématologie, Centre G. Hayem, Hôpital Saint Louis, AP-HP Paris Cedex, France. toubert@histo.chu-stlouis.fr
Charron
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D000941:Antigens / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007156:Immunologic Memory / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014181:Transplantation Immunology / Q000276:immunology*
D000941:Antigens