title: Chromosome stability, DNA recombination and the BRCA2 tumour suppressor.
abstract: The BRCA2 tumour suppressor works in DNA recombination and repair pathways to preserve genome integrity. Recent progress provides fresh insights into its role as a regulator of the Rad51 recombination protein, underpinning a model in which BRCA2's involvement in chromosome stability and tumour suppression arises from its participation in recombinational processes essential for DNA replication.
authors.affiliation: University of Cambridge, CRC Department of Oncology, The Cambridge Institute for Medical Research, Hills Road, Cambridge CB2 2XY, UK. arv22@cam.ac.uk
authors.forename: A R
authors.initials: AR
authors.lastname: Venkitaraman
mesh_terms: D024682:BRCA2 Protein; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D004260:DNA Repair / Q000235:genetics*; D004261:DNA Replication / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics / Q000502:physiology*; D006801:Humans; D008938:Mitosis / Q000235:genetics / Q000502:physiology; D009154:Mutation / Q000235:genetics; D009363:Neoplasm Proteins / Q000235:genetics* / Q000378:metabolism*; D051135:Rad51 Recombinase; D011995:Recombination, Genetic / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology
chemical_list: D024682:BRCA2 Protein; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D014157:Transcription Factors; C495153:RAD51 protein, human; D051135:Rad51 Recombinase