A case of lichenoid purpura possibly caused by diltiazem hydrochloride.
A 65-year-old Japanese man presented with itchy purpuric lichenoid papules of six months' duration on his legs and buttock. A topical glucocorticoid ointment was not effective. The biopsy specimen histologically showed a dense lichenoid infiltration of lymphocytes and histiocytes into the dermoepidermal junction; red blood cells were seen in the infiltration. Based on the clinical and pathological findings, we diagnosed this case as lichenoid purpura of Gougerot-Blum. The lesions disappeared when the diltiazem hydrochloride that he had been taking was discontinued.
Inui
S
S
Department of Dermatology, Graduate School of Medicine, Osaka University, 2-2, C-5, Yamadaoka, Suita-shi, Osaka, 565-0871, Japan.
Itami
S
S
Yoshikawa
K
K
D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004110:Diltiazem / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007866:Leg; D008297:Male; D011693:Purpura / Q000139:chemically induced* / Q000175:diagnosis* / Q000473:pathology
D000959:Antihypertensive Agents; D004110:Diltiazem