[Chemotherapy by combination of low-dose CPT-11 and PSK in an elderly man with liver metastasis from gastric cancer].
We attempted a new regimen of low-dose CPT-11 and PSK against a high age man with liver metastasis from gastric cancer. CPT-11 was administered at 20 mg/m2/day x 2/week, and PSK was given orally 3.0 g/day daily, respectively. Serum CEA level decreased gradually and almost reached normal limits (130 to 3.0 ng/ml). The tumor was reduced more than 50% at 13 weeks after the start of chemotherapy, when it had been continued for more than 8 weeks. There were no adverse effects and this regimen has been continued for more than 20 weeks without missing a week. These results suggest that the combination of low-dose CPT-11 and PSK has fewer side effects even in an elderly patient and may induce not only tumor shrinkage but also a prolonged time to progression.
Takahashi
Y
Y
Dept. of Surgical Oncology, Cancer Research Institute, Kanazawa University.
Mai
M
M
D000368:Aged; D000369:Aged, 80 and over; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004334:Drug Administration Schedule; D006801:Humans; D007155:Immunologic Factors / Q000008:administration & dosage; D000077146:Irinotecan; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary*; D008297:Male; D011509:Proteoglycans / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000473:pathology*
D000972:Antineoplastic Agents, Phytogenic; D007155:Immunologic Factors; D011509:Proteoglycans; C010770:polysaccharide-K; D000077146:Irinotecan; D002166:Camptothecin