Origin of ovarian cancer from benign cysts.
In a case-control study of 1031 epithelial ovarian cancers and 2311 controls conducted in Italy, 56 cases and 116 controls reported history of benign ovarian cysts, corresponding to a relative risk of 1.3 (95% confidence interval = 0.9-1.8). In a subset of 255 histologically reviewed cases, mucinous and endometrioid ovarian neoplasms and neoplasms of stage I or II arose more frequently from cysts, while use of oral contraceptives or parity were not significantly related to history of ovarian cysts.
Dal Maso
L
L
Centro di Riferimento Oncologico, Aviano (PN), Italy.
Canzonieri
V
V
Talamini
R
R
Franceschi
S
S
La Vecchia
C
C
D002288:Adenocarcinoma, Mucinous / Q000209:etiology* / Q000503:physiopathology; D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000209:etiology* / Q000503:physiopathology; D016022:Case-Control Studies; D003276:Contraceptives, Oral; D005260:Female; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D016017:Odds Ratio; D010048:Ovarian Cysts / Q000150:complications*; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000503:physiopathology; D010298:Parity; D012307:Risk Factors
D003276:Contraceptives, Oral