Role of ETS family transcription factors in vascular development and angiogenesis.
The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif. This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors. This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.
Sato
Y
Y
Department of Vascular Biology, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan. y-sato@idac.tohoku.ac.jp
D000818:Animals; D004730:Endothelium, Vascular / Q000254:growth & development / Q000502:physiology*; D006801:Humans; D005810:Multigene Family / Q000502:physiology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors / Q000502:physiology*
C494041:ETS1 protein, human; D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors