[Effects of topical prostaglandin analogues on the aqueous flare intensity in rabbit eyes at an early phase of endotoxin-induced uveitis].
OBJECTIVE
We examined the effects of prostaglandin analogues on the blood-aqueous barrier(BAB) permeability in rabbit eyes at an early phase of endotoxin-induced uveitis(EIU).


METHODS
One drop of 0.005% latanoprost or 0.12% unoprostone were applied to rabbit eyes. Escherichia coli lipopolysaccharides were injected to induce uveitis. The changes in flare intensity in normal eyes and EIU eyes after application of eye drops were evaluated. The effect of cyclooxygenase inhibitor on the flare intensity changes caused by the application of unoprostone was also examined.


RESULTS
Flare intensity increased significantly after a single instillation of unoprostone, and the increase was not prevented by pretreatment with cyclooxygenase inhibitor. In eyes with EIU, unoprostone caused an additional increase of flare intensity to uveitis induced flare change. Latanoprost had no effects on BAB in eyes with normal and with uveitic conditions.


CONCLUSIONS
Latanoprost and unoprostone did not cause an excessive inflammatory reaction in rabbit eyes at an early phase of EIU.
Kiuchi
Y
Y
Department of Ophthalmology, Osaka National Hospital, 2-1-14 Hoenzaka, Chuo-ku, Osaka 540-0006, Japan.
Itaya
H
H
Shiotani
Y
Y
Nakae
K
K
Ishimoto
I
I
Hori
Y
Y
Sato
S
S
Fukui
K
K
Kubo
M
M
Hayashida
Y
Y
Ohnishi
T
T
Tsukamoto
Y
Y
Morioka
J
J
D000818:Animals; D018916:Blood-Aqueous Barrier / Q000187:drug effects*; D015237:Dinoprost / Q000031:analogs & derivatives / Q000494:pharmacology*; D005260:Female; D000077338:Latanoprost; D008297:Male; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D011817:Rabbits; D014605:Uveitis / Q000139:chemically induced / Q000503:physiopathology*
D011461:Prostaglandins F, Synthetic; C072630:isopropyl unoprostone; D000077338:Latanoprost; D015237:Dinoprost