Two essential amino acids, L-lysine and L-histidine, in five types of experimental seizures.
L-Lysine (250-2,000 mg/kg) and L-histidine (1,000-2,000 mg/kg) significantly raised the electroconvulsive threshold. D-Histidine (1,000 mg/kg) was completely ineffective in this regard. Both amino acids were generally inactive in pentetrazole-, picrotoxin- and aminophylline-induced seizures, though L-histidine (2,500 mg/kg) significantly reduced the number of mice with clonic convulsions in the pentetrazole test. Also, L-lysine (2,500 and 3,000 mg/kg) significantly diminished mortality rate in aminophylline-induced seizures. In addition, L-lysine (2,500-3,000 mg/kg) and L-histidine (2,000-2,500 mg/kg) delayed the onset of aminophylline- and picrotoxin-evoked convulsions. L-Lysine and L-histidine (both up to 1,000 mg/kg) did not affect amygdala-kindled seizures in rats. The results indicate that some of indispensable amino acids may play a role in the inhibitory transmission in the central nervous system. A possibility arises that appropriate diet may be an important supportive factor in the treatment of some epileptic patients, probably suffering from generalized tonic-clonic seizures.
Borowicz
K K
KK
Department of Pathophysiology, Medical University, Lublin, Poland.
Swiader
M
M
Kamiński
R
R
Kuźniar
H
H
Kleinrok
Z
Z
Czuczwar
S J
SJ
D000628:Aminophylline; D000679:Amygdala / Q000502:physiology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D003292:Convulsants; D004558:Electric Stimulation; D004597:Electroshock; D005260:Female; D006639:Histidine / Q000494:pharmacology*; D007696:Kindling, Neurologic / Q000187:drug effects / Q000502:physiology; D008239:Lysine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D010852:Picrotoxin; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D000628:Aminophylline; D000927:Anticonvulsants; D003292:Convulsants; D006639:Histidine; D008239:Lysine; D010433:Pentylenetetrazole; D010852:Picrotoxin