title: Genomic imprinting and cancer; new paradigms in the genetics of neoplasia.
abstract: The role of epigenetic modification of gene expression is becoming increasingly important in how we understand the loss of tumour suppressor gene function in a variety of tumours and tumour predisposing syndromes. This review explores the importance of epimutation in Beckwith-Wiedemann syndrome and Wilms' tumour and focuses on genomic methylation in both imprinted and non-imprinted genes as a key mechanism in the development of cancer.
authors.affiliation: Laboratory of Stem Cell Biology, Department of Anatomy, University of Cambridge, Downing Street, CB2 3DY, Cambridge, UK. ps@mole.bio.cam.ac.uk
authors.forename: P N
authors.initials: PN
authors.lastname: Schofield
authors.forename: J A
authors.initials: JA
authors.lastname: Joyce
authors.forename: W K
authors.initials: WK
authors.lastname: Lam
authors.forename: V
authors.initials: V
authors.lastname: Grandjean
authors.forename: A
authors.initials: A
authors.lastname: Ferguson-Smith
authors.forename: W
authors.initials: W
authors.lastname: Reik
authors.forename: E R
authors.initials: ER
authors.lastname: Maher
mesh_terms: D000375:Aging; D001506:Beckwith-Wiedemann Syndrome / Q000235:genetics; D019175:DNA Methylation; D020868:Gene Silencing; D016147:Genes, Tumor Suppressor; D018392:Genomic Imprinting; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D005810:Multigene Family; D009369:Neoplasms / Q000235:genetics*
chemical_list: D007335:Insulin-Like Growth Factor II