[Acute polyradiculoneuritis and dysautonomia: contribution of assaying catecholamines and their methoxylated metabolites].
Guillain-Barré syndrome is an acute demyelinating polyradiculoneuritis usually evolving with rapid, functional recovery. In severely paralysed patients, cranial nerve palsy and autonomic nervous system dysfunctions are common. Lesions of the spinal roots predominate but segmentary demyelination of peripheral nervous system reflects various clinical subtypes. Twelve patients (42,8 p. cent) had clinical dysautonomia. Ten had an increase of urinary methoxylated metabolites. Patients exempt of dysautonomia had normal biological parameters. The elevated level of urinary methoxylated metabolites is statistically correlated to clinical dysautonomia and can be used as a biological marker to monitoring demyelinating polyradiculoneuritis.
Lebrun
C
C
Service de neurologie, Hôpital Pasteur, Nice Cedex, France.
Ghetau
G
G
Candito
M
M
Chatel
M
M
D001342:Autonomic Nervous System Diseases / Q000175:diagnosis* / Q000652:urine; D015415:Biomarkers; D004837:Epinephrine / Q000652:urine*; D005260:Female; D020275:Guillain-Barre Syndrome / Q000175:diagnosis* / Q000652:urine; D006801:Humans; D008297:Male; D008676:Metanephrine / Q000652:urine*; D008875:Middle Aged; D009460:Neurologic Examination; D008771:Nordefrin / Q000652:urine*; D009638:Norepinephrine / Q000652:urine*; D011237:Predictive Value of Tests
D015415:Biomarkers; D008676:Metanephrine; D008771:Nordefrin; D009638:Norepinephrine; D004837:Epinephrine