Is oxidative stress involved in the aetiology of pre-eclampsia?
Pre-eclampsia is one of the major indications for elective premature delivery. Several lines of evidence suggest that pre-eclampsia is associated with a state of oxidative stress, offering hope of prevention by antioxidant supplementation. It was recently shown by the present authors that supplementation with vitamin C and E from early in pregnancy leads to a reduction in the incidence of the disease in "high-risk" women.
Poston
L
L
Department of Obstetrics and Gynaecology, Guy's, King's and St. Thomas' School of Medicine, St. Thomas' Hospital, London, UK. lucilla.poston@kcl.ac.uk
Chappell
L C
LC
D000975:Antioxidants / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use; D005260:Female; D006801:Humans; D018384:Oxidative Stress / Q000502:physiology*; D011225:Pre-Eclampsia / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology*; D011247:Pregnancy; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D014810:Vitamin E; D001205:Ascorbic Acid