Mechanisms in anti-inflammation and resolution: the role of lipoxins and aspirin-triggered lipoxins.
Multicellular host responses to infection, injury or inflammatory stimuli lead to the formation of a broad range of chemical mediators by the host. The integrated response of the host is essential to health and disease; thus it is important to achieve a more complete understanding of the molecular and cellular events governing the formation and actions of endogenous mediators of resolution that appear to control the duration of inflammation. Lipoxins are trihydroxytetraene-containing lipid mediators that can be formed during cell-cell interactions and are predominantly counterregulators of some well-known mediators of inflammation. Since this circuit of lipoxin formation and action appears to be of physiological relevance for the resolution of inflammation, therapeutic modalities targeted at this system are likely to have fewer unwanted side effects than other candidates and current anti-inflammatory therapies. Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators.
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Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. iolanda@uerj.br
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D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology*; D012898:Autacoids / Q000096:biosynthesis; D016207:Cytokines / Q000502:physiology; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000096:biosynthesis / Q000276:immunology / Q000502:physiology*; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D018836:Inflammation Mediators / Q000378:metabolism / Q000502:physiology*; D008055:Lipids / Q000096:biosynthesis*; D044045:Lipoxins; D008084:Lipoxygenase / Q000096:biosynthesis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D012898:Autacoids; D016207:Cytokines; D006893:Hydroxyeicosatetraenoic Acids; D018836:Inflammation Mediators; D008055:Lipids; D044045:Lipoxins; C040527:lipoxin A4; D008084:Lipoxygenase; D001241:Aspirin