Structure determination and comparison of BM567, a sulfonylurea, with terbogrel, two compounds with dual action, thromboxane receptor antagonism and thromboxane synthase inhibition.
BM567, a sulfonylurea compound whose crystal structure is here discussed and terbogrel, are both thromboxane receptor antagonists and thromboxane synthase inhibitors. In this paper, their crystallographic and electronic structures are compared and lead to new synthesis prospects among the sulfonylurea series.
Michaux
C
C
Lab. Chimie Moleculaire Structurale, Facultés Universitaires N.-D. de la Paix, Namur, Belgium. catherine.michaux@scf.fundp.ac.be
Rolin
S
S
Dogné
J M
JM
Durant
F
F
Masereel
B
B
Delarge
J
J
Wouters
J
J
D003461:Crystallography; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D015394:Molecular Structure; D011725:Pyridines / Q000737:chemistry* / Q000494:pharmacology*; D017482:Receptors, Thromboxane / Q000037:antagonists & inhibitors*; D013054:Spectrophotometry, Atomic / Q000379:methods; D055672:Static Electricity; D013453:Sulfonylurea Compounds / Q000737:chemistry* / Q000494:pharmacology*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
C434802:BM 567; D011725:Pyridines; D017482:Receptors, Thromboxane; D013453:Sulfonylurea Compounds; C112331:terbogrel; D013930:Thromboxane-A Synthase