A sesquiterpene drimane with antinociceptive activity from Drimys winteri bark.
Along with three known drimanes, polygodial. 1-beta-(p-methoxycinnamoyl) polygodial and mukaadial, the sesquiterpene drimane named drimanial was isolated from the bark of Drimys winteri (Winteraceae). Its structure was elucidated based on spectroscopic evidence. Drimanial exhibited antinociceptive action against acetic acid induced pain, being about 3-fold less active than polygodial.
Malheiros
A
A
Departamento de Farmacologia, Trindade, Universidade Federal de Santa Catarina, Florianópolis, SC, Brazil.
Filho
V C
VC
Schmitt
C B
CB
Santos ARS
Scheidt
C
C
Calixto
J B
JB
Monache
F D
FD
Yunes
R A
RA
D000700:Analgesics / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology*; D013057:Spectrum Analysis
D000700:Analgesics; D000081223:Polycyclic Sesquiterpenes; D012717:Sesquiterpenes; C437376:drimane