title: Androgen-producing, atypically proliferating endometrioid tumor arising in endometriosis.
abstract: A case of androgen-secreting borderline endometrioid tumor arising in endometriosis of the rectovaginal septum is presented. It occurred 10 years after total abdominal hysterectomy and bilateral salpingo-oophorectomy for extensive endometriosis of the fallopian tubes and ovaries, adenomyosis, and leiomyomas of the uterus. We believe 7 years of unopposed continuous oral estrogen replacement therapy contributed to the malignant transformation of the endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, New Hanover Regional Medical Center, Wilmington, NC, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Powell
authors.forename: G P
authors.initials: GP
authors.lastname: Connor
authors.forename: G S
authors.initials: GS
authors.lastname: Henderson
mesh_terms: D015746:Abdominal Pain / Q000209:etiology; D000728:Androgens / Q000378:metabolism*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018269:Carcinoma, Endometrioid / Q000150:complications* / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003131:Combined Modality Therapy; D004414:Dyspareunia / Q000209:etiology; D004715:Endometriosis / Q000150:complications* / Q000601:surgery; D015914:Estrogen Replacement Therapy / Q000009:adverse effects / Q000379:methods; D005260:Female; D006628:Hirsutism / Q000209:etiology; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D008940:Mitotic Index; D010052:Ovariectomy; D012004:Rectal Neoplasms / Q000150:complications* / Q000473:pathology*; D012086:Reoperation; D014057:Tomography, X-Ray Computed; D014625:Vaginal Neoplasms / Q000150:complications* / Q000473:pathology*
chemical_list: D000728:Androgens