title: Synthesis and biochemical evaluation of some novel N-acyl phosphono- and phosphinoalanine derivatives as potential inhibitors of the D-glutamic acid-adding enzyme.
abstract: A series of N-(5-phthalimidopentanoyl)-, N-[2-(2-ethoxy)acetyl]-, and N-(7-oxooctanoyl)-phosphono and phosphinoalanine derivatives has been synthesized and evaluated for inhibition of the D-glutamic acid-adding enzyme (MurD) of peptidoglycan biosynthesis.
authors.affiliation: Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia. gobecs@ffa.uni-lj.si
authors.forename: S
authors.initials: S
authors.lastname: Gobec
authors.forename: U
authors.initials: U
authors.lastname: Urleb
authors.forename: G
authors.initials: G
authors.lastname: Auger
authors.forename: D
authors.initials: D
authors.lastname: Blanot
mesh_terms: D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000737:chemistry; D000409:Alanine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D007202:Indicators and Reagents
chemical_list: D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D000119:Acetylmuramyl-Alanyl-Isoglutamine; D000409:Alanine