Simultaneous breast cancer in non-identical Ashkenazi Jewish twins: management dilemmas when genetic testing is negative.
We present the case histories of Ashkenazi Jewish twins of opposite sex who developed breast cancer simultaneously, in whom testing for the anticipated BRCA2 mutations was unexpectedly negative. Their management and the implications of this difficult situation are discussed.
Sibtain
A
A
St Bartholomew's Hospital, London, UK.
Eeles
R
R
Wellwood
J
J
Plowman
P N
PN
D000328:Adult; D019313:BRCA1 Protein / Q000235:genetics*; D024682:BRCA2 Protein; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D018567:Breast Neoplasms, Male / Q000235:genetics* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000235:genetics* / Q000473:pathology; D005260:Female; D005817:Genetic Counseling; D006801:Humans; D007585:Jews; D008297:Male; D009363:Neoplasm Proteins / Q000235:genetics*; D010375:Pedigree; D014157:Transcription Factors / Q000235:genetics*; D014429:Twins, Dizygotic
D019313:BRCA1 Protein; D024682:BRCA2 Protein; D009363:Neoplasm Proteins; D014157:Transcription Factors