Estrus variation in anticonflict effects of midazolam microinjected into septal nuclei in female Wistar rats.
Effects of midazolam intraperitoneally (3.0 mg/kg) administered, or locally applied into lateral septal nuclei (10 microg/microl), or into the medial septum (10 microg/microl) were assessed in Wistar rats during late proestrus or metestrus-diestrus in a conflict-operant task. A reduction in conflict behavior was found in control rats during late proestrus (P<.05), when compared to metestrus-diestrus. Systemic injections of midazolam (P<.05) or midazolam infusions into lateral septal nuclei (P<.05) also reduced conflict behavior only during late proestrus, whereas midazolam infusions into the medial septum produced neither of these anticonflict effects in any estrous phase. In conclusion, an endocrine-related variation in anticonflict effects of midazolam microinjected into lateral septal nuclei was displayed by female rats.
Molina-Hernández
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Laboratorio de Conducta, Instituto de Investigaciones Psicológicas, Universidad Veracruzana, PO Box 361, CP 91000 Veracruz, Jalapa, Mexico. mimoli@bugs.invest.uv.mx
Téllez-Alcántara
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D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects*; D003220:Conflict, Psychological; D004971:Estrus / Q000523:psychology*; D005260:Female; D008845:Microinjections; D008874:Midazolam / Q000008:administration & dosage / Q000494:pharmacology*; D011678:Punishment; D051381:Rats; D017208:Rats, Wistar; D012686:Septal Nuclei / Q000033:anatomy & histology / Q000502:physiology*; D013238:Stereotaxic Techniques
D014151:Anti-Anxiety Agents; D008874:Midazolam