title: Correlation between family history of hypertension and haemostatic disorders.
abstract: BACKGROUND
  The aim of this study was to evaluate whether a family history of hypertension is associated with haemostatic disorders.
  
  
  METHODS
  In 38 normotensive subjects with a family history of hypertension (relatives) and in 46 sex, age and body mass index matched controls with no family history of hypertension, tissue-type plasminogen activator (t-PA), plasminogen activator-inhibitor (PAI-1), D-dimer (DD) and prothrombin fragment 1+2 (F1+2) were evaluated.
  
  
  RESULTS
  The t-PA and PAI-1 observed values were significantly higher than the values detected in the controls.
  
  
  CONCLUSIONS
  These data seem to suggest a correlation between family history of hypertension and haemostatic disorders.
authors.affiliation: Department of Internal Medicine, University of Messina, Via Monsignor D'Arrigo, 23-98121 Messina, Italy. atrifiletti@tin.it
authors.forename: A
authors.initials: A
authors.lastname: Trifiletti
authors.forename: R
authors.initials: R
authors.lastname: Scamardi
authors.forename: M
authors.initials: M
authors.lastname: Cincotta
authors.forename: G
authors.initials: G
authors.lastname: Sottilotta
authors.forename: A
authors.initials: A
authors.lastname: Gaudio
authors.forename: C
authors.initials: C
authors.lastname: Romano
authors.forename: L
authors.initials: L
authors.lastname: Sottile
authors.forename: A
authors.initials: A
authors.lastname: Lasco
mesh_terms: D000328:Adult; D001778:Blood Coagulation Disorders / Q000209:etiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics*; D008297:Male