Macrophages and T-cell apoptosis in HIV infection: a leading role for accessory cells?
Recent studies indicate that macrophages modulate T-cell apoptosis in HIV infection. Macrophages have been shown to trigger apoptosis of uninfected bystander T cells and to protect HIV-infected T cells from apoptosis. This article raises the possibility that macrophages, via modulation of T-cell apoptosis, play a crucial role in both immune suppression and the formation of viral reservoirs during HIV infection.
Mahlknecht
U
U
University of Frankfurt, Dept of Hematology/Oncology, Frankfurt am Main, Germany.
Herbein
G
G
D000938:Antigen-Presenting Cells / Q000276:immunology*; D017209:Apoptosis; D015658:HIV Infections / Q000276:immunology* / Q000821:virology*; D007108:Immune Tolerance; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology / Q000821:virology*; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology*