title: Comparison of the test methods (KRYPTOR, ES 600 and CIS-RIA) for CEA, CA 15-3 and CA 125 follow-up and ONCOCHECK-quality control.
abstract: We examined whether the automated KRYPTOR/CIS analysis system could replace the routine tumor marker tests. We analysed the sera of 50 patients by EnzymImmunoAssay CEA (ES-600, Roche/Boehringer), CA 15-3 (ELSA/RIA; CIS) CA 125 (Centocor/RIA; CIS) and in parallel by KRYPTOR (CIS). The correlation coefficient for CEA and CA 125 was clearly less than that of Centocor. Although the automated KRYPTOR is suitable for routine analysis a larger number of patients sera must be tested by different methods, especially in view of the lack of international reference material, before completely switching over to KRYPTOR.
authors.affiliation: Department of Gynecology and Obstetrics, Philipps University Marburg, Pilgrimstein 3, D-35037 Marburg, Germany. thomas.bauer@med.uni-marburg.de
authors.forename: T
authors.initials: T
authors.lastname: Bauer
authors.forename: S
authors.initials: S
authors.lastname: Charl
authors.forename: G
authors.initials: G
authors.lastname: Sturm
mesh_terms: D001331:Automation; D014408:Biomarkers, Tumor / Q000032:analysis*; D018394:CA-125 Antigen / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D019411:Clinical Laboratory Techniques; D005500:Follow-Up Studies; D006801:Humans; D018396:Mucin-1 / Q000032:analysis*; D011786:Quality Control; D011933:Reagent Kits, Diagnostic
chemical_list: D014408:Biomarkers, Tumor; D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D018396:Mucin-1; D011933:Reagent Kits, Diagnostic