Raised platelet thiobarbituric acid-reacting substances in proliferative Eales' disease.
BACKGROUND
Platelets are an elective site for oxidative stress owing to their high content of polyunsaturated fatty acid. Increased lipid peroxidation and elevated platelet thiobarbituric acid-reacting substances (TBARS) signal oxidative stress. This possibly leads to retinal neovascularization in Eales' disease.


METHODS
TBARS levels were estimated in consecutive cases of Eales' disease with neovascularisation (n = 26), Eales' disease without neovascularisation (n = 17) and healthy controls (n = 17).


RESULTS
Platelet TBARS levels in the cases of Eales' disease with neovascularisation, Eales' disease without neovascularisation, and healthy controls were 0.66 +/- 0.1, 0.57 +/- 0.11 and 0.42 +/- 0.14 n moles TBARS formed/hour/10(8) platelets respectively. Student's t-test showed a significant increase in platelet TBARS levels in cases with neovascularisation as compared to cases without neovascularization (p < 0.05) and healthy controls (p < 0.01).


CONCLUSIONS
The increase in platelet TBARS levels in proliferative Eales' disease is consistent with an emerging view that lipid peroxides may be associated with retinal neovascularisation.
Srivastava
P
P
King George's Medical College, Lucknow, India.
Saxena
S
S
Khanna
V K
VK
Kumar
D
D
Nath
R
R
Seth
P K
PK
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D018450:Disease Progression; D006801:Humans; D015227:Lipid Peroxidation / Q000502:physiology; D008054:Lipid Peroxides / Q000097:blood; D012164:Retinal Diseases / Q000097:blood* / Q000150:complications / Q000473:pathology; D015861:Retinal Neovascularization / Q000097:blood / Q000209:etiology / Q000473:pathology; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism*; D014657:Vasculitis / Q000097:blood* / Q000150:complications / Q000473:pathology
D015415:Biomarkers; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances