Rat epididymal fat tissue express all components of the renin-angiotensin system.
In the present study the gene expression of components of the renin-angiotensin system was investigated in fat tissue of rats. mRNAs for angiotensinogen, renin, angiotensin-converting enzyme and type I (AT1) angiotensin II receptor were detected in the stromal-vascular fraction of the fat tissue and the same mRNAs, with the exception of the angiotesin-converting enzyme, in the adipocyte fraction. Renin and angiotensin-converting enzyme activity was measured. The main source of renin activity was found in adipocytes and some minor activity in the stromal-vascular fraction, while the majority of the angiotensin-converting enzyme activity was in the stromal-vascular fraction. The present data provide evidence for the presence of the active renin-angiotensin system in rat adipose tissue.
Pinterova
L
L
Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia.
Krizanova
O
O
Zorad
S
S
D000273:Adipose Tissue / Q000378:metabolism*; D000808:Angiotensinogen / Q000096:biosynthesis; D000818:Animals; D017931:DNA Primers / Q000378:metabolism; D004822:Epididymis / Q000378:metabolism*; D015870:Gene Expression; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000096:biosynthesis; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin / Q000096:biosynthesis; D012083:Renin / Q000096:biosynthesis; D012084:Renin-Angiotensin System
D017931:DNA Primers; D012333:RNA, Messenger; D044140:Receptor, Angiotensin, Type 1; D011945:Receptors, Angiotensin; D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A; D012083:Renin