Pregnancy with cytochrome oxidase-deficient mitochondrial myopathy.
BACKGROUND
Cytochrome oxidase-deficient mitochondrial myopathies represent a heterogeneous group of muscle disorders. Physical stress can cause life-threatening risks related to rhabdomyolysis or respiratory compromise.


METHODS
A 21-year-old primigravida with cytochrome C oxidase-deficient mitochondrial myopathy who presented for obstetric care at 8 weeks' gestation complained of muscle fatigue and spasm after exertion. The increased metabolic demands of pregnancy led to worsening pain, muscle fatigue, and ultimately complete immobility.


CONCLUSIONS
Cytochrome oxidase-deficient mitochondrial myopathies are rare but serious complications of pregnancy.
Soccio
P S
PS
Department of Obstetrics and Gynecology, Memorial University of Newfoundland, 300 Prince Phillip Drive, St. John's, Newfoundland A1B 3V6, Canada.
Phillips
W P
WP
Bonisteel
P
P
Bennett
K A
KA
D000328:Adult; D030401:Cytochrome-c Oxidase Deficiency; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D017240:Mitochondrial Myopathies / Q000628:therapy*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*; D011256:Pregnancy Outcome; D011295:Prenatal Care