title: Hemodialysis followed by continuous hemofiltration for treatment of lithium intoxication in children.
abstract: Hemodialysis is the usual recommended treatment for severe lithium intoxication; however, rebound of lithium levels may require repeated hemodialysis treatments. We proposed that the addition of continuous hemofiltration after hemodialysis would prevent rebound by providing ongoing clearance of lithium. We report two pediatric patients with lithium intoxication treated by hemodialysis followed by continuous venovenous hemofiltration with dialysis (CVVHD). Both patients were symptomatic at presentation and had initial lithium levels more than three times the usual therapeutic range. Hemodialysis followed by CVVHD resulted in rapid resolution of symptoms, followed by continuous clearance of lithium without requiring repeated hemodialysis sessions. Both patients had return of normal mental status during CVVHD treatment, and neither patient experienced complications of hemodialysis or CVVHD. Total duration of treatment with hemodialysis followed by CVVHD was 34.5 hours for the first patient and 26 hours for the second patient. We conclude that hemodialysis followed by CVVHD is a safe and effective approach to the management of lithium intoxication in children.
authors.affiliation: Department of Pediatrics, Section of Pediatric Critical Care, University of Arizona, Tucson, AZ, USA. rjmeyer@peds.arizona.edu
authors.forename: R J
authors.initials: RJ
authors.lastname: Meyer
authors.forename: J T
authors.initials: JT
authors.lastname: Flynn
authors.forename: P D
authors.initials: PD
authors.lastname: Brophy
authors.forename: W E
authors.initials: WE
authors.lastname: Smoyer
authors.forename: D B
authors.initials: DB
authors.lastname: Kershaw
authors.forename: J R
authors.initials: JR
authors.lastname: Custer
authors.forename: T E
authors.initials: TE
authors.lastname: Bunchman
mesh_terms: D000293:Adolescent; D018692:Antimanic Agents / Q000097:blood / Q000506:poisoning*; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D008094:Lithium / Q000097:blood / Q000506:poisoning*; D008297:Male; D011041:Poisoning / Q000628:therapy
chemical_list: D018692:Antimanic Agents; D008094:Lithium