title: The use of becaplermin (rhPDGF-BB) gel for chronic nonhealing ulcers. A retrospective analysis.
abstract: Chronic, nonhealing wounds have plagued health care practitioners for decades. New research and technology have allowed the wound healing process to be understood at a cellular and molecular level, including the vital role of growth factors. This article discusses the effects of platelet-derived growth factor-BB (PDGF-BB) on the wound healing process, emphasizing the inflammatory stage of wound healing and principles of wound care. Preclinical and clinical studies evaluating recombinant human PDGF-BB (rhPDGF-BB) (becaplermin gel) also are discussed. Lastly, the results of a retrospective analysis evaluating the use of rhPDGF-BB at Broadlawns Medical Center (Des Moines, IA) are presented.
authors.affiliation: Foot and Ankle Clinics, Broadlawns Medical Center, Des Moines, Iowa, USA.
authors.forename: V J
authors.initials: VJ
authors.lastname: Mandracchia
authors.forename: S M
authors.initials: SM
authors.lastname: Sanders
authors.forename: J A
authors.initials: JA
authors.lastname: Frerichs
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D005260:Female; D016523:Foot Ulcer / Q000503:physiopathology* / Q000628:therapy*; D005782:Gels; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D007871:Leg Ulcer / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology* / Q000627:therapeutic use*; D003668:Pressure Ulcer / Q000628:therapy; D020033:Protein Isoforms; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D012189:Retrospective Studies; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005782:Gels; D010982:Platelet-Derived Growth Factor; D020033:Protein Isoforms; D011994:Recombinant Proteins