Prevention of brick tea fluorosis in rats with low-fluoride brick tea on laboratory observation.
To test whether low-fluoride brick tea can prevent the occurrence of fluorosis, rats had access only to a specially prepared low-fluoride brick tea for 1 year. The daily fluoride intake, fluoride metabolism, tissue distribution and development of tooth fluorosis were observed at 4-monthly intervals, at the end of months 4, 8 and 12, respectively. Rats drinking ordinary brick tea (F- 503.5 mg/kg) served as control. The daily intake of fluoride in the ordinary brick tea group was 0.3 mg, and this group developed dental fluorosis characterized as brown and white horizontal marks at the end of month 8, and white chalky dental fluorosis developed at the end of month 12. The total incidence was 75%. In contrast, the daily fluoride intake of the low-fluoride brick tea (F- 210 mg/kg) group was 0.19 mg, and this group did not develop any signs of dental fluorosis. Fluoride distribution was mainly retained in the bone tissue, and about half of the absorbed fluoride was excreted via urine and feces. The results suggest that this low-fluoride brick tea did not induce fluorosis in rats and can be used as an effective control measure for humans.
Cao
J
J
Tea and Health Laboratory, Hunan Medical University, Changsha 410078, PR, Hunan, China. caojin@public.cs.hn.cn
Zhao
Y
Y
Liu
J
J
D000367:Age Factors; D000818:Animals; D004195:Disease Models, Animal; D005243:Feces / Q000737:chemistry; D005260:Female; D005459:Fluorides / Q000008:administration & dosage / Q000032:analysis / Q000633:toxicity*; D009050:Fluorosis, Dental / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D015994:Incidence; D007180:Incisor / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013662:Tea / Q000737:chemistry* / Q000633:toxicity; D013997:Time Factors; D014018:Tissue Distribution
D013662:Tea; D005459:Fluorides