title: Requirement of the nicotinic acetylcholine receptor beta 2 subunit for the anatomical and functional development of the visual system.
abstract: In the mammalian visual system the formation of eye-specific layers at the thalamic level depends on retinal waves of spontaneous activity, which rely on nicotinic acetylcholine receptor activation. We found that in mutant mice lacking the beta2 subunit of the neuronal nicotinic receptor, but not in mice lacking the alpha4 subunit, retinofugal projections do not segregate into eye-specific areas, both in the dorso-lateral geniculate nucleus and in the superior colliculus. Moreover, beta2-/- mice show an expansion of the binocular subfield of the primary visual cortex and a decrease in visual acuity at the cortical level but not in the retina. We conclude that the beta2 subunit of the nicotinic acetylcholine receptor is necessary for the anatomical and functional development of the visual system.
authors.affiliation: Laboratoire de Neurobiologie Moléculaire, Centre National de la Recherche Scientifique, Unité de Recherche Associée 2182, Récepteurs et Cognition, Institut Pasteur, 28 Rue du Dr. Roux, 75724 Paris Cédex 15, France.
authors.forename: F M
authors.initials: FM
authors.lastname: Rossi
authors.forename: T
authors.initials: T
authors.lastname: Pizzorusso
authors.forename: V
authors.initials: V
authors.lastname: Porciatti
authors.forename: L M
authors.initials: LM
authors.lastname: Marubio
authors.forename: L
authors.initials: L
authors.lastname: Maffei
authors.forename: J P
authors.initials: JP
authors.lastname: Changeux
mesh_terms: D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D011978:Receptors, Nicotinic / Q000235:genetics / Q000378:metabolism* / Q000502:physiology; D012160:Retina / Q000502:physiology; D015348:Vision, Binocular / Q000502:physiology; D014792:Visual Acuity / Q000502:physiology; D014793:Visual Cortex / Q000033:anatomy & histology / Q000502:physiology*
chemical_list: D011978:Receptors, Nicotinic; C403531:nicotinic receptor alpha4beta2