title: The extent of osteocyte death in the proximal femur of patients with osteonecrosis of the femoral head.
abstract: Our aim was to assess the local extent of osteocyte death in the proximal femur of 16 patients with osteonecrosis of the femoral head. We performed histological examination of the femoral heads and cancellous bone biopsies from four regions of the proximal femur in patients undergoing total hip arthroplasty. A control group consisted of 19 patients with osteoarthritis. All histological specimens were examined in a blinded fashion. Extensive osteonecrosis was shown in the proximal femur up to 4 cm below the lesser trochanter in the group with osteonecrosis. There was an overall statistically significant difference in the extent of osteocyte death distal to the femoral head between the two groups (p < 0.001). We discuss the implications of these findings as possible contributing factors in regard to the early failure of total hip arthroplasty reported in patients with osteonecrosis of the femoral head.
authors.affiliation: Imperial College School of Medicine, London, England.
authors.forename: J D
authors.initials: JD
authors.lastname: Calder
authors.forename: M F
authors.initials: MF
authors.lastname: Pearse
authors.forename: P A
authors.initials: PA
authors.lastname: Revell
mesh_terms: D000328:Adult; D019644:Arthroplasty, Replacement, Hip; D016923:Cell Death; D005260:Female; D005269:Femur / Q000473:pathology*; D005271:Femur Head Necrosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000473:pathology; D010011:Osteocytes / Q000473:pathology*