Ampicillin-resistant Escherichia coli in gestational pyelonephritis: increased occurrence and association with the colonization factor Dr adhesin.
The pattern of ampicillin resistance and possible association with virulence factors of 78 Escherichia coli isolates taken from 78 pregnant women with pyelonephritis were evaluated. The current incidence of ampicillin resistance among pyelonephritis isolates (46%) was significantly higher than that reported in 1985 (22%). Resistance was found more frequently during the first (60%) and third (53%) trimesters than during the second trimester (33%). Of all dra(+) E. coli isolates, 75% were ampicillin resistant, whereas dra(+) isolates of O75 serotype E. coli accounted for 87% of ampicillin-resistant strains. The significant increase of ampicillin resistance among gestational pyelonephritis E. coli and the association with the dra gene cluster encoding colonization and invasive capacity may warrant further study involving obstetric and neonate wards, with the latter being at the higher risk for potential problems.
Hart
A
A
Departments of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas, USA.
Nowicki
B J
BJ
Reisner
B
B
Pawelczyk
E
E
Goluszko
P
P
Urvil
P
P
Anderson
G
G
Nowicki
S
S
D018830:Adhesins, Escherichia coli / Q000032:analysis; D000668:Ampicillin Resistance; D001426:Bacterial Proteins / Q000032:analysis*; D004926:Escherichia coli / Q000187:drug effects* / Q000302:isolation & purification / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D005260:Female; D036781:Fimbriae Proteins; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D011264:Pregnancy Trimesters; D011704:Pyelonephritis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D012189:Retrospective Studies; D014774:Virulence
D018830:Adhesins, Escherichia coli; D001426:Bacterial Proteins; C022924:colonization factor antigens; D036781:Fimbriae Proteins