title: Interactions of meso-tetra-(4-N-oxyethylpyridyl) porphyrin, its 3-N analog and their metallocomplexes with duplex DNA.
abstract: Interactions of meso-tetra-(4-N-oxyethylpyridyl) porphyrin (TOEPyP(4)), its 3-N analog (TOEPyP(3)) and their Co, Cu, Ni, Zn metallocomplexes with duplex DNA have been investigated by uv/visible absorbance and circular dichrosim spectroscopies. Results reveal the interactions of these complexes with duplex DNA are of two types. (1) External binding of duplex DNA by metalloporphyrins containing Zn and Co, and (2) Binding of duplex DNA both externally and internally (by intercalation) by porphyrins not containing metals, and metalloporphyrins containing Cu and Ni. Results indicate that (4N-oxyethylpyridyl) porphyrins intercalate more preferably in the structure of duplex DNA and have weaker external binding than 3N-porphyrins.
authors.affiliation: Department of Physics, Yerevan State University, Armenia.
authors.forename: Y B
authors.initials: YB
authors.lastname: Dalyan
authors.forename: S G
authors.initials: SG
authors.lastname: Haroutiunian
authors.forename: G V
authors.initials: GV
authors.lastname: Ananyan
authors.forename: V I
authors.initials: VI
authors.lastname: Vardanyan
authors.forename: D Y
authors.initials: DY
authors.lastname: Lando
authors.forename: V N
authors.initials: VN
authors.lastname: Madakyan
authors.forename: R K
authors.initials: RK
authors.lastname: Kazaryan
authors.forename: L
authors.initials: L
authors.lastname: Messory
authors.forename: P
authors.initials: P
authors.lastname: Orioli
authors.forename: A S
authors.initials: AS
authors.lastname: Benight
mesh_terms: D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry*; D008670:Metals; D009692:Nucleic Acid Heteroduplexes; D011166:Porphyrins / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
chemical_list: D008670:Metals; D009692:Nucleic Acid Heteroduplexes; D011166:Porphyrins; C436925:meso-tetra-(4-N-oxyethylpyridyl) porphyrin; D004247:DNA