[Use of a dynamic test with HCG for evaluation of endocrine function in gonads of men with chronic alcohol abuse].
We studied 40 chronic alcoholic men (aged 39 +/- 11) after alcohol withdrawal. We excluded in these patients severe internal organs disorders (first of all liver dysfunction) and seminal pathology. We analysed (in HCG test) plasma levels of: luteinizing hormone--LH, follicle stimulating hormone--FSH, total testosterone--T, free testosterone--fT, estradiol--E, 17-OH progesterone, sex hormone binding globulin--SHBG. Our results suggest: 1) decreased testicular reserve of free testosterone and normal level of total testosterone, 2) decreased initial level and functional reserve of 17-OH progesterone, 3) mild hyperoestrogenism, 4) no significant difference of LH, FSH, SHBG levels between alcoholics and controls, 5) these results were not changed after 6 months observation. These results indicate on subclinic alcoholic hypogonadism.
Kiełkiewicz
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D
Katedra i Klinika Endokrynologii i Diabetologii Akademii Medycznej we Wrocławiu.
Medraś
M
M
Dolna
M
M
D019326:17-alpha-Hydroxyprogesterone / Q000097:blood*; D000328:Adult; D000437:Alcoholism / Q000378:metabolism*; D004958:Estradiol / Q000097:blood*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000097:blood*
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol; D019326:17-alpha-Hydroxyprogesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone