title: Incidence and outcome of patients with adrenal metastases of renal cell cancer.
abstract: OBJECTIVE
  To evaluate the outcome of patients with adrenal metastasis in renal tumors to establish the oncologic necessity of adrenalectomy in these patients. Radical nephrectomy for renal cell cancer includes simultaneous ipsilateral adrenalectomy. Recent reports suggest that adrenal involvement in renal cell cancer is rare and can be predicted by computed tomography or distinct algorithms.
  
  
  METHODS
  In a retrospective analysis of 866 consecutive patients who underwent nephrectomy and adrenalectomy, we established the rate of adrenal metastasis and obtained follow-up information to evaluate disease outcome.
  
  
  RESULTS
  We calculated an adrenal metastasis rate of 3.1% (n = 27); of these 27 patients, only 6 (0.7% of all patients) presented with a solitary adrenal metastasis. Kaplan-Meier analysis demonstrated that patients with solitary adrenal and multiple metastases have a poor outcome. The median survival of patients with localized renal cancer was 43.9 months compared with 21.3 months for patients with a solitary adrenal metastasis and 11.0 months for patients with multiple metastases.
  
  
  CONCLUSIONS
  Ipsilateral, solitary, and synchronous metastases in renal cell cancer are rare and patients have a poor outcome despite surgical resection. Therefore, simultaneous adrenalectomy can be omitted during radical nephrectomy if the preoperative examinations or algorithms used do not predict adrenal metastasis in the patient with renal cell cancer.
authors.affiliation: Department of Urology, Technischen Universitaet Muenchen, Klinikum rechts der Isar, Munich, Germany.
authors.forename: R
authors.initials: R
authors.lastname: Paul
authors.forename: J
authors.initials: J
authors.lastname: Mordhorst
authors.forename: H
authors.initials: H
authors.lastname: Leyh
authors.forename: R
authors.initials: R
authors.lastname: Hartung
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000453:epidemiology / Q000556:secondary* / Q000601:surgery; D000315:Adrenalectomy / Q000379:methods; D002292:Carcinoma, Renal Cell / Q000453:epidemiology / Q000556:secondary* / Q000601:surgery; D005260:Female; D005858:Germany / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007680:Kidney Neoplasms / Q000473:pathology* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy / Q000379:methods; D016019:Survival Analysis; D016896:Treatment Outcome