title: Zeamatin inhibits trypsin and alpha-amylase activities.
abstract: Zeamatin is a 22-kDa protein isolated from Zea mays that has antifungal activity against human and plant pathogens. Unlike other pathogenesis-related group 5 proteins, zeamatin inhibits insect alpha-amylase and mammalian trypsin activities. It is of clinical significance that zeamatin did not inhibit human alpha-amylase activity and inhibited mammalian trypsin activity only at high molar concentrations.
authors.affiliation: Mycologics, Inc., Denver, CO 80262, USA.
authors.forename: R
authors.initials: R
authors.lastname: Schimoler-O'Rourke
authors.forename: M
authors.initials: M
authors.lastname: Richardson
authors.forename: C P
authors.initials: CP
authors.lastname: Selitrennikoff
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001407:Bacillus / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D010179:Pancreas / Q000201:enzymology; D010940:Plant Proteins / Q000494:pharmacology*; D012463:Saliva / Q000201:enzymology; D013552:Swine; D014231:Tribolium / Q000201:enzymology; D014357:Trypsin / Q000378:metabolism*; D014361:Trypsin Inhibitors / Q000494:pharmacology; D003313:Zea mays / Q000201:enzymology; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
chemical_list: D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D010940:Plant Proteins; D014361:Trypsin Inhibitors; C073468:zeamatin protein, Zea mays; D000516:alpha-Amylases; D014357:Trypsin