[Interleukins in chronic viral hepatitis].
OBJECTIVE
To estimate interleukines levels in chronic hepatitis (CH) in respect to CH etiological factor, activity and stage.


METHODS
Enzyme immunoassay (kits from proteinovy Kontur, St-Petersburg) determined levels of IL-1 beta, IL-4, IL-6 and TNF-alpha in the peripheral blood of 250 patients with chronic hepatitis C (CHC), B (CHB), D (CHD) and G (CHG).


RESULTS
IL concentrations in chronic viral hepatitis depend on etiological factor (CHC, CHB, CHD, CHG), activity (high, moderate, low), stage (chronic hepatitis, cirrhosis). IL occur in high quantities in CHC, in moderate concentrations in CHB and in minimal ones in CHG. Maximal IL levels were observed in high hepatitis activity at the stage of hepatic cirrhosis. TNF-alpha and IL-4 concentrations rose more frequently and higher than IL-6 and IL-1 beta (43 and 34%, up to 315 pg/ml and 256 pg/ml, respectively).
Loginov
A S
AS
Tsaregorodtseva
T M
TM
Zotina
M M
MM
Serova
T I
TI
Iakimchuk
G N
GN
Fedotova
T F
TF
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002908:Chronic Disease; D005260:Female; D018067:Flaviviridae; D019694:Hepatitis B, Chronic / Q000097:blood; D019698:Hepatitis C, Chronic / Q000097:blood; D019701:Hepatitis D, Chronic / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D007375:Interleukin-1 / Q000097:blood; D015847:Interleukin-4 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007378:Interleukins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis
D007375:Interleukin-1; D015850:Interleukin-6; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D015847:Interleukin-4