Impairment of deglutition reflex by acid-induced esophageal mucosal injury.
Swallowing is an important defense mechanism against reflux esophagitis as it helps clear refluxed gastric contents from the esophagus, while bicarbonate in the saliva acts to neutralize acid. The purpose of the present study was to examine the effect of esophagitis on the deglutition reflex in anesthetized opossums. Animals perfused with either an acidified pepsin solution for 45 min or with 100 mM hydrochloric acid for 45 min on each of three consecutive days exhibited a significantly impaired deglutition reflex in comparison to baseline. Control animals perfused with 0.9% saline showed no impairment. Bilateral cervical vagotomy in animals perfused with acidified pepsin attenuated the impaired deglutition reflex. Taken together, these results suggest that esophagitis causes an impairment in the deglutition reflex that is mediated by vagal afferent pathways.
White
R J
RJ
Gastrointestinal Diseases Research Unit, Queen's University, Kingston, Ontario, Canada.
Morris
G P
GP
Paterson
W G
WG
D000818:Animals; D003679:Deglutition; D004941:Esophagitis / Q000139:chemically induced / Q000503:physiopathology*; D005260:Female; D006851:Hydrochloric Acid / Q000008:administration & dosage; D008297:Male; D009092:Mucous Membrane / Q000503:physiopathology; D009893:Opossums; D012021:Reflex, Abnormal
D006851:Hydrochloric Acid