Surfactant protein D and KL-6 as serologic indicators of Pneumocystis carinii pneumonia in a child with acute lymphoblastic leukemia.
Pneumocystis carinii pneumonia (PCP) in immunocompromised patients is one of the important causes of morbidity and mortality. Serum levels of surfactant protein D (SP-D) and KL-6 are useful biomarkers for understanding some pulmonary inflammatory responses in patients with idiopathic pulmonary fibrosis (IPF). We present a child with PCP following bone marrow transplantation (BMT) for acute lymphoblastic leukemia (ALL), for whom both SP-D and KL-6 in sera were simultaneously measured through the clinical course of PCP. Both serum levels of SP-D and KL-6 were rapidly elevated reflecting some inflammatory processes in the lung that chest X-ray films and CT scans showed as ground-glass attenuations. He died due to respiratory failure 40 days after PCP developed. A combination of the assays for SP-D and KL-6 in sera may be helpful in predicting the treatment results for PCP.
Takahashi
T
T
Department of Infectious Diseases and Applied Immunology, Institute of Medical Science, University of Tokyo, 4-6-1, Shirokanedai, Minato-ku, Tokyo 108-8639, Japan. takahata@ims.u-tokyo.ac.jp
Ebihara
Y
Y
Manabe
A
A
Tsuji
K
K
Nakamura
T
T
Nakahata
T
T
Iwamoto
A
A
D000293:Adolescent; D000941:Antigens; D000951:Antigens, Neoplasm; D016026:Bone Marrow Transplantation; D017809:Fatal Outcome; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D018396:Mucin-1; D009077:Mucins; D011020:Pneumonia, Pneumocystis / Q000097:blood / Q000175:diagnosis* / Q000209:etiology*; D011183:Postoperative Complications; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000601:surgery*; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants / Q000097:blood*; D013902:Radiography, Thoracic; D012698:Serologic Tests; D014057:Tomography, X-Ray Computed
D000941:Antigens; D000951:Antigens, Neoplasm; D006023:Glycoproteins; C060192:MUC1 protein, human; D018396:Mucin-1; D009077:Mucins; D037663:Pulmonary Surfactant-Associated Protein D; D011663:Pulmonary Surfactants