title: Thiosugars. Part 9: synthesis and biological evaluation of some 4'-thio-L-arabino nucleoside analogues.
abstract: 1-O-Acetyl-2,3,5-tri-O-benzyl-4-thio-L-arabinofuranose (10) was transformed into the corresponding cytidine derivative 9 and the adenosine derivative 12. Both nucleosides, as well as the previously reported uridine and thymidine analogues 2 and 3, were tested for their in vitro antiviral activity.
authors.affiliation: Institut für Organische Chemie der Universität Hamburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Wirsching
authors.forename: J
authors.initials: J
authors.lastname: Voss
authors.forename: G
authors.initials: G
authors.lastname: Adiwidjaja
authors.forename: J
authors.initials: J
authors.lastname: Balzarini
authors.forename: E
authors.initials: E
authors.lastname: De Clercq
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis / Q000494:pharmacology; D003562:Cytidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects*; D006801:Humans; D008968:Molecular Conformation; D018165:Orthoreovirus / Q000187:drug effects*; D013872:Thionucleosides / Q000138:chemical synthesis / Q000494:pharmacology; D013936:Thymidine / Q000031:analogs & derivatives / Q000494:pharmacology; D014529:Uridine / Q000031:analogs & derivatives / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000998:Antiviral Agents; D013872:Thionucleosides; D003562:Cytidine; D000241:Adenosine; D013936:Thymidine; D014529:Uridine