Analysis of chromosomal aberrations in men occupationally exposed to cement dust.
Cement industry is considered as a major pollution problem on account of dust and particulate matter emitted at various steps of cement manufacture. Cement dust consists of many toxic constituents. The workers who are employed in cement industries are exposed to cement dust for long periods. Therefore, it is mandatory to evaluate the mutagenic effects of occupational exposure to cement dust in such workers. In the present study, we analyzed the samples of 124 male workers including 59 smokers and 65 non-smokers who were employed in cement industry for a period of 1-17 years. For comparison, 106 controls (including 47 smokers and 59 non-smokers) of the same age group and socio-economic status were also studied. Controls had no exposure to cement dust or any known physical or chemical agent. A significant increase in the incidence of chromosomal aberrations was observed in the exposed group when compared to the control group. The results were analyzed separately for non-smokers and smokers. The chromosomal damage was more pronounced in the smokers when compared with the non-smokers both in control and exposed groups. A significant increase in the frequency of chromosomal aberrations was also observed with increase in age in both control and exposed subjects.
Fatima
S K
SK
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad (A.P.) 500016, India.
Prabhavathi
P A
PA
Padmavathi
P
P
Reddy
P P
PP
D000328:Adult; D000367:Age Factors; D017607:Aluminum Compounds / Q000633:toxicity; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003252:Construction Materials; D004391:Dust / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D017640:Silicates / Q000633:toxicity; D012907:Smoking / Q000235:genetics
D017607:Aluminum Compounds; D004391:Dust; D017640:Silicates