title: Cervical cancer detection by hybrid capture and evaluation of local risk factors.
abstract: The city of Recife, northeastern Brazil, is reported to have the highest incidence of cervical cancer worldwide (83.2/100000 women).
  
  
  OBJECTIVE
  To evaluate the efficacy of Hybrid Capture I (HC I) in cervical cancer detection and some risk factors in Recife.
  
  
  METHODS
  Cervical scrapes for HC I analysis followed by colposcopy were collected from 140 women (70 with cervical cancer and 70 with normal cervix) from three screening services in Recife.
  
  
  RESULTS
  HC I sensitivity and specificity were 82.9 and 41.4%, respectively. The odds ratios for cervical cancer when Gesta > or = 5 and vaginal parity > or = 4 were, respectively, 5.30 and 4.27.
  
  
  CONCLUSIONS
  HC I is a moderately sensitive method to detect cervical cancer, but it does not seem to be useful as a primary screening tool for it's low specificity. Early pregnancy, high Gesta/Para and living in rural areas were important local risk factors.
authors.affiliation: Department of Gynecology and Obstetrics, Instituto Materno-Infantil de Pernambuco (IMIP), Recife, PE, Brazil. f.lorenzato@ucl.ac.uk
authors.forename: F
authors.initials: F
authors.lastname: Lorenzato
authors.forename: A
authors.initials: A
authors.lastname: Singer
authors.forename: T
authors.initials: T
authors.lastname: Mould
authors.forename: L C
authors.initials: LC
authors.lastname: Santos
authors.forename: A
authors.initials: A
authors.lastname: Maia
authors.forename: L
authors.initials: L
authors.lastname: Cariri
mesh_terms: D000328:Adult; D001938:Brazil / Q000453:epidemiology; D016022:Case-Control Studies; D004279:DNA, Viral / Q000302:isolation & purification; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000235:genetics / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011446:Prospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014412:Tumor Virus Infections / Q000150:complications / Q000175:diagnosis* / Q000453:epidemiology; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000209:etiology / Q000821:virology*; D019562:Viral Load
chemical_list: D004279:DNA, Viral