A chronology of fine-scale gene mapping by linkage disequilibrium.
The past decade produced several proposals for fine-scale gene mapping using linkage disequilibrium data. The suggested methods fall into two main groups, those that rely on pairwise statistics and those that rely on haplotypes. This paper reviews each strategy's development from a chronological perspective.
Lazzeroni
L C
LC
Biostatistics Division, Department of Health Research and Policy, Stanford University, Stanford, California 94305, USA. Lazzeroni@stanford.edu
D000483:Alleles; D001699:Biometry; D002874:Chromosome Mapping / Q000379:methods* / Q000706:statistics & numerical data / Q000639:trends; D003550:Cystic Fibrosis / Q000235:genetics; D006239:Haplotypes; D006801:Humans; D016013:Likelihood Functions; D015810:Linkage Disequilibrium; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation; D011995:Recombination, Genetic