Effects of the green algae Chlorella vulgaris on the response of the host hematopoietic system to intraperitoneal ehrlich ascites tumor transplantation in mice.
Chlorella vulgaris extract (CVE) was examined for its effects on the Ehrlich ascites tumor-induced suppression in the numbers of bone marrow and spleen granulocyte-macrophage progenitor cells (CFU-GM) in mice. No effects on bone marrow and spleen CFU-GM, as compared to controls, were observed in normal mice given 50, 100 and 200 mg/kg CVE orally for 5 days. In tumor-bearing mice, myelosuppression concomitant with increased number of spleen CFU-GM were observed. The number of CFU-GM in the bone marrow was restored to control levels after the administration of CVE (50, 100 and 200 mg/kg) to tumor-bearing mice, and a slight reduction in spleen colony formation was observed in these animals. In addition, CVE significantly prolonged the survival of mice inoculated with the Ehrlich ascites tumor. These results suggest a protective antitumor effect of CVE which might be attributable, at least in part, to the stimulation of the production and, possibly, maturation of granulocytes and macrophages.
Justo
G Z
GZ
Department of Pharmacology and Hemocentre, Faculdade de Ciências Médicas, Universidade Estadual de Campinas (UNICAMP), SP, Brazil.
Silva
M R
MR
Queiroz
M L
ML
D000284:Administration, Oral; D000818:Animals; D001854:Bone Marrow Cells / Q000187:drug effects*; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology*; D002478:Cells, Cultured; D002708:Chlorella; D003114:Colony-Forming Units Assay; D005856:Germ-Free Life; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000187:drug effects*; D006411:Hematopoiesis, Extramedullary / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007274:Injections, Intraperitoneal; D019891:Leukopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010936:Plant Extracts / Q000032:analysis / Q000494:pharmacology*; D011994:Recombinant Proteins; D013154:Spleen / Q000166:cytology; D015996:Survival Rate
D010936:Plant Extracts; D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor