Eosinophilic gastroenteritis treated with non-enteric-coated budesonide tablets.
A patient who presented with upper abdominal pain, nausea and ascites together with peripheral eosinophilia is described. Based on a surgical full-thickness biopsy of the antrum, the diagnosis of eosinophilic gastroenteritis was made. Treatment with prednisone resulted in a clinical response, but the prednisone dose could not be lowered below 5 mg. We preferred to treat the patient with corticosteroids with minimal systemic side effects. As there was gastric involvement, we could not give enteric-coated budesonide capsules. Therefore, we treated the patient with budesonide tablets, which were designed originally for use as a clysma but now are given orally. With this treatment regimen, the patient has been in remission for more than 2 years.
Tan
A C
AC
Department of Gastroenterology and Hepatology, University Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands. a.tan@hccnet.nl
Kruimel
J W
JW
Naber
T H
TH
D000328:Adult; D019819:Budesonide / Q000008:administration & dosage / Q000627:therapeutic use*; D004802:Eosinophilia / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D005759:Gastroenteritis / Q000188:drug therapy* / Q000473:pathology; D005938:Glucocorticoids / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans
D005938:Glucocorticoids; D019819:Budesonide