Continuous recycling: a mechanism for modulatory signal transduction.
Modulatory signal transduction commonly requires efficient "on demand" assembly of specific multicomponent cellular machines that convert signals to cellular actions. This article suggests that for these signaling machines to detect and respond to fluctuations in signal strength, they must be continuously disassembled in an energy-dependent process that probably involves molecular chaperones.
Freeman
B C
BC
Dept of Cellular and Molecular Pharmacology, University of California-San Francisco, 513 Parnassus, San Francisco, CA 94143-0450, USA.
Yamamoto
K R
KR
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004967:Estrogens / Q000097:blood; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008024:Ligands; D008954:Models, Biological; D018832:Molecular Chaperones / Q000378:metabolism; D011485:Protein Binding; D012333:RNA, Messenger / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D015398:Signal Transduction; D013997:Time Factors
D004967:Estrogens; D008024:Ligands; D018832:Molecular Chaperones; D012333:RNA, Messenger; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D006854:Hydrocortisone