Basic fibroblast growth factor induced angiogenesis and prefabricated flap survival.
Prefabrication of a latissimus dorsi myocutaneous flap was performed in adult male Landrace pigs. Gelfoam sponges were used as a delivery system for basic fibroblast growth factor (bFGF) at the muscle-subcutaneous tissue interface. Skin survival and angiogenesis were augmented in the growth-factor-treated animals. These data support the use of basic fibroblast growth factor to enhance flap prefabrication.
Haws
M J
MJ
Division of Plastic Surgery, University of Nevada School of Medicine, Las Vegas 89102-2227, USA.
Erdman
D
D
Bayati
S
S
Brown
R E
RE
Russell
R C
RC
D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D005781:Gelatin Sponge, Absorbable; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D023421:Models, Animal; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D013524:Surgical Flaps / Q000098:blood supply*; D013552:Swine
D016222:Fibroblast Growth Factor 2