Could platelet activating factor play a role in developmental dyslexia?
Post-mortem studies by Galaburda and colleagues on the brains of developmental dyslexics found characteristic neuronal abnormalities: ectopias, microgyria, and fewer large-soma cells in sensory thalamus. An association between dyslexia and immune dysfunction has also been proposed. We describe a mechanism which may explain these observations. Platelet-activating factor (PAF) is a pro-inflammatory lipid implicated in neurological disorders. We propose that PAF may also be involved in dyslexia.
Taylor
K E
KE
University of Oxford, UK. Kathleen.taylor@physiol.ox.ac.uk
Richardson
A J
AJ
Stein
J F
JF
D001921:Brain / Q000002:abnormalities / Q000378:metabolism; D004410:Dyslexia / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D008040:Genetic Linkage; D006801:Humans; D010972:Platelet Activating Factor / Q000096:biosynthesis / Q000502:physiology*
D010972:Platelet Activating Factor