Congenital malformations of the nervous system: a neuropathologic perspective.
Neurologists and neuropathologists face new diagnostic challenges in the era of molecular genetics and should strive to integrate descriptive morphologic data with the emerging understanding of genetic programming of ontogenesis. This integration is of particular importance in defining and understanding malformations of the developing brain and spinal cord. Both medical specialists have much to contribute to the clinical neurobiology of the twenty-first century, but new tools and perspectives are required.
Sarnat
H B
HB
Department of Neurology, University of Washington School of Medicine, Seattle, Washington, USA. harvey.sarnat@cshs.org
D001921:Brain / Q000002:abnormalities* / Q000473:pathology; D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000235:genetics / Q000473:pathology*; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013116:Spinal Cord / Q000002:abnormalities* / Q000473:pathology