Role of mononuclear phagocyte system in hemopoiesis regulation in AKR/JY mice during preleukemic period.
Feeder activity of bone marrow adherent cells and peritoneal macrophages is decreased and colony-stimulating and erythropoietic activity of unfractionated bone marrow increased in highly leukemic AKR/JY mice in comparison with CBA/CaLac mice. At the same time maturation of hemopoietic precursor cells in AKR/JY mice is delayed compared to controls. This indicates compensatory activation of nonadherent elements of the hemopoiesis-inducing microenvironment against the background of suppressed activity of adherent elements. Hence, leukemogenic virus produced a systemic damage to target cells (e.g. mononuclear phagocyte system), which probably represent a mechanism of leukemic transformation in AKR/JY mice.
Stavrova
L A
LA
Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences.
Dygai
A M
AM
Zhdanov
V V
VV
Gol'dberg
E D
ED
Tkachenko
S B
SB
D000818:Animals; D001854:Bone Marrow Cells / Q000502:physiology*; D002478:Cells, Cultured; D005260:Female; D006410:Hematopoiesis / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000502:physiology; D008264:Macrophages / Q000502:physiology*; D017737:Macrophages, Peritoneal / Q000502:physiology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008808:Mice, Inbred CBA; D011289:Preleukemia / Q000503:physiopathology*