title: Discrimination between normal and glaucomatous eyes with visual field and scanning laser polarimetry measurements.
abstract: OBJECTIVE
  To evaluate the ability of structural parameters (as determined by retinal nerve fibre layer (RNFL) measurements obtained with the scanning laser polarimeter (SLP-NFA/GDx)) and functional parameters (as determined by automated perimetry) to discriminate between normal and glaucomatous eyes.
  
  
  METHODS
  In a case-control study, a total of 91 normal subjects and 94 patients with glaucoma underwent automated perimetry and RNFL measurements obtained with the SLP. Three independent scans of each eye were obtained and a mean image was created and used for further analysis. Only one eye per individual was randomly included in the study. The sensitivity (Se) and specificity (Sp) of 12 RNFL parameters were calculated according to the SLP internal normative database. The Se and Sp of the visual field (VF) global indices and the glaucoma hemifield test (GHT) were also calculated according to the instrument's normative database. Receiver operator characteristic (ROC) curves were built for each SLP parameter and VF index. Fisher's linear discriminant formulas (LDFs) were developed for VF indices (VF LDF), SLP measurements (SLP LDF), and both examinations (combined LDF).
  
  
  RESULTS
  According to the SLP internal database, the parameters with better Se and Sp were: superior/nasal ratio (Se = 58.5%; Sp = 86.8%), and GDx the number (Se = 43.3%; Sp = 96.7%). The construction of an ROC curve for the number resulted in Se = 84% and Sp = 79%. The creation of LDFs improved both the sensitivities and specificities when compared with isolated parameters SLP LDF (Se = 90.4%; Sp = 82.4%), VF LDF (Se = 89.4%; Sp = 89.0%), and combined LDF (Se = 93.0%; Sp = 90.1%). The sensitivity to diagnose early and moderate glaucomatous damage observed with the GHT was lower than that obtained with the number (p < 0.01).
  
  
  CONCLUSIONS
  Creation of LDFs enhanced the Se and Sp for both VF and SLP. Integration of SLP and VF in a combined LDF reached the highest Se/Sp relation, suggesting that these examinations may be additive concerning the diagnosis of glaucoma. The SLP parameter the number may be more sensitive than the GHT in diagnosing early and moderate glaucomatous damage.
authors.affiliation: Glaucoma Service, Department of Ophthalmology, University of Campinas, Brazil. rlauande@hotmail.com
authors.forename: R
authors.initials: R
authors.lastname: Lauande-Pimentel
authors.forename: R A
authors.initials: RA
authors.lastname: Carvalho
authors.forename: H C
authors.initials: HC
authors.lastname: Oliveira
authors.forename: D C
authors.initials: DC
authors.lastname: Gonçalves
authors.forename: L M
authors.initials: LM
authors.lastname: Silva
authors.forename: V P
authors.initials: VP
authors.lastname: Costa
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D005260:Female; D005902:Glaucoma, Open-Angle / Q000175:diagnosis*; D006801:Humans; D008297:Male; D018613:Microscopy, Confocal; D008875:Middle Aged; D012372:ROC Curve; D012016:Reference Values; D012160:Retina / Q000473:pathology*; D012680:Sensitivity and Specificity; D058609:Visual Field Tests / Q000379:methods*