title: Giant cell arteritis and secondary amyloidosis: the natural history.
abstract: Giant cell (temporal) arteritis (GCA) may be a cause of fever of unknown origin (FUO) in elderly patients. The development of secondary (reactive) amyloidosis is an unusual complication of the disease. We describe a 65-year-old male patient who was hospitalized in our hospital with FUO and was diagnosed as having GCA 5 years later. At that time, he also had a nephrotic syndrome and secondary amyloidosis (AA-type). He died due to end-stage renal failure. The probable explanation for the development of this rare complication might be the late diagnosis of this chronic inflammatory disease, which was left untreated for a long period of time.
authors.affiliation: Department of Nephrology, Cerrahpasa Medical Faculty, University of Istanbul, Turkey.
authors.forename: M R
authors.initials: MR
authors.lastname: Altiparmak
authors.forename: F
authors.initials: F
authors.lastname: Tabak
authors.forename: O N
authors.initials: ON
authors.lastname: Pamuk
authors.forename: G E
authors.initials: GE
authors.lastname: Pamuk
authors.forename: A
authors.initials: A
authors.lastname: Mert
authors.forename: Y
authors.initials: Y
authors.lastname: Aktuğlu
mesh_terms: D000368:Aged; D000682:Amyloid / Q000032:analysis / Q000145:classification; D000686:Amyloidosis / Q000209:etiology* / Q000473:pathology; D017809:Fatal Outcome; D005335:Fever of Unknown Origin / Q000209:etiology / Q000473:pathology; D013700:Giant Cell Arteritis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D013699:Temporal Arteries / Q000473:pathology
chemical_list: D000682:Amyloid; D011241:Prednisone