[Bone marrow involvement in ovarian cancer determined by immunohistochemical methods].
Atypical epithelial cells in the bone marrow of patients with ovarian cancer were evaluated using immunohistochemical techniques. We investigated cytospin preparations of bone marrow taken from 9 women with benign ovarian tumors and 59 women with malignant ovarian tumors. Two monoclonal antibodies (NCL-C11 and NCL-CA 125) were used. With both antibodies we were able to detect keratin and CA 125 antigen expression in the bone marrow of 9 (18.4%) of the patients with ovarian cancer. With regard to the wide histological differentiation of ovarian carcinomas, the presence of atypical epithelial cells in the bone marrow was required as a prognostic factor for survival and relapses. This should be investigated in a larger study group.
Gabriel
M
M
Klinik für Allgemeine und Gefässchirurgie, Medizinische Universität Poznań, Polen. mgabriel@pro.onet.pl
Obrebowska
A
A
Spaczyński
M
M
D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D019046:Bone Marrow Neoplasms / Q000401:mortality / Q000473:pathology / Q000556:secondary*; D018394:CA-125 Antigen / Q000032:analysis*; D005260:Female; D006801:Humans; D007633:Keratins / Q000032:analysis*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000401:mortality / Q000473:pathology*; D011379:Prognosis; D015996:Survival Rate
D018394:CA-125 Antigen; D007633:Keratins