[Detection of human papillomaviruses in cervical intraepithelial neoplasms].
Over the period 1994-1998 1000 patients suffering from intraepithelial cervical lesions (SIL) were examined for the presence of Human Papilloma Virus (HPV) infection. Today it is completely acknowledged that certain types of these viruses play a key role in the onset and evolution of these diseases. The study showed that SIL of the cervix appears in very young women. The highest incidence was found in age groups 24-28 years (21.10%) and 29-33 years (19.10%). Thus, over 40% of the entire study group patients was under 34 years of age. Histological analysis of tissue samples showed that 79.30% of patients had lesions of low histological grade (LSIL), while in 20.70% of them the disease progressed to a high histological level (HSIL). Detection of Human Papilloma Virus Infection revealed negative results in 34.90% of patients, 17.80% were 6/11 positive (non-oncogenic type), and in 47.30% oncogenic types were found (16, 18, 31, 33). This finding in the LSIL group was exceptionally important since it influenced the approach to treatment. Oncogenic types of viruses were detected in 34.30% of LSIL lesions; it indicates a high progression potential of pathological changes.
Stanimirović
B
B
Narodni front Department of Gynaecology and Obstetrics, Belgrade.
Kuljić-Kapulica
N
N
Popović-Lazić
J
J
Stanimirović
V
V
Vasiljević
M
M
D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008875:Middle Aged; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000175:diagnosis*; D014412:Tumor Virus Infections / Q000150:complications / Q000175:diagnosis*; D002583:Uterine Cervical Neoplasms / Q000821:virology*; D002578:Uterine Cervical Dysplasia / Q000821:virology*