Formation of morphine tolerance in offspring of morphine-tolerant animals: neurochemical and neuroimmune correlates.
We carried out a complex physiological, neurochemical, and neuroimmunologic study of the formation of tolerance to analgetic effect of morphine and analyzed enkephalinase A activity in different brain structures and serotonin antibodies in the serum. More early development of morphine tolerance and a sharp increase in serum antibody titer was found in the offspring of morphine-tolerant rats. This points to an imbalance in the neurotransmitter system and can serve as a diagnostic marker of endogenous opioid system pathology.
Litvinova
S V
SV
Department of Higher Nervous Activity, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow. shulg@protein.bio.msu.ru
Aristova
V V
VV
Shul'govskii
V V
VV
Basharova
L A
LA
Terebilina
N N
NN
Panchenko
L F
LF
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D001323:Autoantibodies / Q000097:blood; D001921:Brain / Q000201:enzymology; D004361:Drug Tolerance / Q000502:physiology; D005260:Female; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009021:Morphine Dependence; D015260:Neprilysin / Q000378:metabolism; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000276:immunology
D000701:Analgesics, Opioid; D001323:Autoantibodies; D012701:Serotonin; D009020:Morphine; D015260:Neprilysin