Gene imprinting in developmental toxicology: a possible interface between physiology and pathology.
Gene imprinting is an epigenetic mechanism for accomplishing persistent change in gene expression. In this brief paper, we explore the mechanisms for imprinting genes and present data showing that the synthetic estrogen, diethylstilbestrol (DES) can developmentally imprint genes by changing the pattern of DNA methylation. We further discuss the implications of this and other findings for non-mutagenic aspects of developmental toxicology, and suggest ways to use this concept in modifying in vitro screening for developmental toxicants.
McLachlan
J A
JA
Environmental Endocrinology Laboratory, Center for Bioenvironmental Research, Tulane and Xavier Universities, 1340 Tulane Avenue, New Orleans, LA 70112, USA. john.mclachlan@tulane.edu
Burow
M
M
Chiang
T C
TC
Li
S F
SF
D000818:Animals; D019175:DNA Methylation / Q000187:drug effects; D004054:Diethylstilbestrol / Q000633:toxicity; D004967:Estrogens / Q000633:toxicity; D005333:Fetus / Q000187:drug effects*; D018392:Genomic Imprinting; D006801:Humans; D014116:Toxicology
D004967:Estrogens; D004054:Diethylstilbestrol