[The value of marker antigens TPS, SCC and CEA in diagnosis, evaluation of histologic type and clinical disease progression in patients with cervical carcinoma].
Pretreatment values TPS, SCC and CEA were measured in 84 patients with cervical carcinoma in order to evaluate the usefulness of markers in diagnosis, estimation of the histological type, estimation of stage of disease and grade of cellular differentiation. TPS was raised in 78.4%, SCC was raised in 71.8% and CEA was raised in 32.4% patients with cervical carcinoma. The frequency of increased results and absolute value of TPS and SCC levels showed tendency to significant increase with the stage of disease and to the grade of cellular differentiation. The highest sensitivities TPS and SCC were observed in patients with carcinoma planoepitheliale macrocellulare akeratodes, CEA in adenocarcinoma clarocellulare. These results suggest that TPS especially in the combination with SCC may be useful in the diagnosis and estimation of stage of disease of patients with cervical carcinoma.
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Zakład Laboratoryjnej Diagnostyki Klinicznej AM w Białymstoku.
D000230:Adenocarcinoma / Q000175:diagnosis / Q000473:pathology; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D014408:Biomarkers, Tumor / Q000097:blood*; D001706:Biopsy; D002272:Carcinoembryonic Antigen / Q000097:blood*; D002277:Carcinoma / Q000145:classification / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D012680:Sensitivity and Specificity; D015843:Serpins; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis*
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen; D010455:Peptides; D015843:Serpins; C051072:squamous cell carcinoma-related antigen; C089984:tissue polypeptide specific antigen