Factors controlling axonal and dendritic arbors.
The sculpting and maintenance of axonal and dendritic arbors is largely under the control of molecules external to the cell. These factors include both substratum-associated and soluble factors that can enhance or inhibit the outgrowth of axons and dendrites. A large number of factors that modulate axonal outgrowth have been identified, and the first stages of the intracellular signaling pathways by which they modify process outgrowth have been characterized. Relatively fewer factors and pathways that affect dendritic outgrowth have been described. The factors that affect axonal arbors form an incompletely overlapping set with those that affect dendritic arbors, allowing selective control of the development and maintenance of these critical aspects of neuronal morphology.
Keith
C H
CH
Department of Cellular Biology. University of Georgia, Athens, 30605, USA.
Wilson
M T
MT
D000818:Animals; D001369:Axons / Q000502:physiology*; D002118:Calcium / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000378:metabolism; D003712:Dendrites / Q000502:physiology*; D005109:Extracellular Matrix / Q000737:chemistry; D007150:Immunohistochemistry; D009414:Nerve Growth Factors / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology
D015815:Cell Adhesion Molecules; D009414:Nerve Growth Factors; D018377:Neurotransmitter Agents; D011956:Receptors, Cell Surface; D002118:Calcium