Thyroid storm in a child following radioactive iodine (RAI) therapy: a consequence of RAI versus withdrawal of antithyroid medication.
A 7.5-yr-old boy with Graves' disease, difficult to control with antithyroid medication and radioactive iodine (RAI) therapy, developed thyroid storm encephalopathy on day 13 after withdrawal of methimazole therapy, 4 days after iodine-131 treatment. We attributed his thyroid storm to withdrawal of antithyroid medication as opposed to RAI therapy. We interpret this case as indicating that there may be a need to reevaluate the duration of antithyroid medication withdrawal before RAI therapy for hyperthyroid children at increased risk for thyroid storm.
Kadmon
P M
PM
Department of Pediatrics, Rhode Island Hospital and Brown University, Providence, Rhode Island 02903, USA.
Noto
R B
RB
Boney
C M
CM
Goodwin
G
G
Gruppuso
P A
PA
D013956:Antithyroid Agents / Q000009:adverse effects*; D002648:Child; D006111:Graves Disease / Q000628:therapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects*; D008297:Male; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D013958:Thyroid Crisis / Q000209:etiology*
D013956:Antithyroid Agents; D007457:Iodine Radioisotopes