[Analysis of mutations A3243G, C3256T and mitochondrial deletions in 41 diabetic patients].
BACKGROUND
Mutations or deletions of mitochondrial DNA (mtDNA) define a new diabetes subtype.


METHODS
The A3243G and C3256T mutations and mtDNA deletions were studied in 41 diabetic patients with maternally inherited diabetes mellitus or deafness.


RESULTS
The A3243G mutation was found in one out of forty-one diabetic patients (2.4%). Neither the C3256T mutation nor mtDNA deletions were detected.


CONCLUSIONS
The search of A3243G mutation has to be considered in a diabetic patient with deafness and/or maternal history of diabetes.
Biarnésa
J
J
Departamento de Genética Médica y Molecular. IRO. Hospital Duran i Reynals. Barcelona. endocrino@htrueta.scs.es
Rojas
I
I
Fernández-Castañer
M
M
Nunes
V
V
Gómez
M
M
Ricart
W
W
D000328:Adult; D015992:Body Mass Index; D004272:DNA, Mitochondrial / Q000032:analysis / Q000235:genetics*; D003920:Diabetes Mellitus / Q000145:classification / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D017353:Gene Deletion; D006319:Hearing Loss, Sensorineural / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D013997:Time Factors
D004272:DNA, Mitochondrial