Metabolic bioenergy homeostatic disruption: a cause of anorexia nervosa.
We believe anorexia nervosa is the result of a disruption in bioenergy homeostasis induced by lipid dysregulation. This disruption has two major determinants: (1) a biological predisposition to primary multihormonal disharmony linked to post-pubertal growth and development; and (2) an acquired abnormal lipid-induced loop operation precipitated by inappropriate diet. We present a step-by-step model describing the cascade of disorders that culminates in anorexia nervosa: defective digestion and absorption of essential fatty acids; diversion of lipids from adipose cells into bloodstream; defective carbohydrate and lipid metabolism which modifies the blood brain barrier; neuroendocrine membrane alteration causing severe endocrine impairment; changes in the negative feedback mechanism which escalate the body's use of bioenergy; derangement of the appetite center which causes a constant sensation of satiety; replacement of the correct body image with the premorbid one that encourages poor judgement concerning food intake and self-support. The loop-like nature of this mechanism perpetuates the disease.
Naisberg
Y
Y
Sha'ar Menashe Mental Health Center, Mobile Post Hefer, Israel.
Modai
I
I
Weizman
A
A
D000273:Adipose Tissue / Q000378:metabolism; D000856:Anorexia Nervosa / Q000209:etiology* / Q000378:metabolism; D001066:Appetite / Q000502:physiology*; D001828:Body Image; D004068:Digestive System Physiological Phenomena; D004734:Energy Metabolism; D006706:Homeostasis; D006801:Humans; D009748:Nutrition Disorders / Q000378:metabolism; D012039:Regional Blood Flow