Frequency and CT findings of recurrent disease after lung transplantation.
OBJECTIVE
To determine the frequency and computed tomographic (CT) findings of recurrence of the primary disease after lung transplantation at six North American lung transplantation centers.


METHODS
Medical records of 1,394 lung transplant recipients were reviewed to identify patients with recurrent primary disease. Their CT scans and pathologic specimens were reviewed.


RESULTS
The frequency of disease recurrence in the six transplantation centers was 1% (15 of 1,394 patients), including six previously reported cases. Sarcoidosis recurred in nine (35%) of 26 transplants and was the most common disease to recur. Three (33%) of nine patients with recurrent sarcoidosis had correlative findings at CT. When present, CT findings were usually different at recurrence compared with pretransplantation CT findings.


CONCLUSIONS
A relatively small percentage of patients are at risk for recurrence of primary disease following lung transplantation. Sarcoidosis is the most common disease to recur.
Collins
J
J
Department of Radiology, University of Wisconsin Hospital and Clinics, E3/311 Clinical Science Center, 600 Highland Ave, Madison, WI 53792-3252, USA. jcollin4@facstaff.wisc.edu
Hartman
M J
MJ
Warner
T F
TF
Müller
N L
NL
Kazerooni
E A
EA
McAdams
H P
HP
Slone
R M
RM
Parker
L A
LA
D000328:Adult; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000473:pathology; D008171:Lung Diseases / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D016040:Lung Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D017565:Sarcoidosis, Pulmonary / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed