title: Methotrexate as a possible trigger of macrophage activation syndrome in systemic juvenile idiopathic arthritis.
abstract: Macrophage activation syndrome (MAS) is a potentially life threatening complication of chronic rheumatic diseases, particularly systemic juvenile idiopathic arthritis (JIA). A number of triggers have been related to the development of MAS, including viral infections, nonsteroidal antiinflammatory drug therapy, and gold salt injections. We describe a patient with systemic JIA who developed MAS shortly after receiving methotrexate, suggesting that this drug can be regarded as a potential trigger of MAS in children with JIA.
authors.affiliation: Dipartimento di Scienze Pediatriche, Università di Pavia, Istituto di Ricovero e Cura a Carattere Scientifico S. Matteo, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Ravelli
authors.forename: M C
authors.initials: MC
authors.lastname: Caria
authors.forename: S
authors.initials: S
authors.lastname: Buratti
authors.forename: C
authors.initials: C
authors.lastname: Malattia
authors.forename: F
authors.initials: F
authors.lastname: Temporini
authors.forename: A
authors.initials: A
authors.lastname: Martini
mesh_terms: D018501:Antirheumatic Agents / Q000009:adverse effects*; D001171:Arthritis, Juvenile / Q000188:drug therapy*; D002648:Child; D005260:Female; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000187:drug effects*; D008727:Methotrexate / Q000009:adverse effects*; D013577:Syndrome
chemical_list: D018501:Antirheumatic Agents; D008727:Methotrexate