Radioimmunoimaging of human breast cancer xenografts in nude mice by using human anti-human breast cancer monoclonal antibodies.
In this study, the human breast cancer-bearing nude mice model has been established and the radioimmunoimaging was carried out by using human anti-human monoclonal antibodies. The results showed that the breast tumor-bearing nude mice received 131I-McAb-CM-1 had a clear image of the xenograft during 4 to 6 days after injection and at the same time T/NT all over 1.0. The highest T/NT reached 7.1. It demonstrates that McAb-CM-1 can specially combine with breast cancer tissues and hopefully it could be used clinically to improve accurate rate of the early breast cancer diagnosis.
Sun
Q
Q
Department of Surgery, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730.
Wang
S
S
Huang
H
H
Yang
Z
Z
Zhu
Y
Y
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis*; D000912:Antibodies, Neoplasm / Q000032:analysis*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D016719:Radioimmunodetection
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D007457:Iodine Radioisotopes