Kinetics of urinary trypsin inhibitor in patients undergoing partial hepatectomy.
BACKGROUND
The kinetics and role of urinary trypsin inhibitor (UTI) in liver surgery are unclear. We investigated the effects of preoperative liver function and the extent of liver resection on postoperative UTI synthesis in the liver after partial hepatectomy.


METHODS
Sixty-one consecutive patients who underwent liver resection were the subjects of the study. Plasma and urine UTI, plasma C reactive protein (CRP) and plasma and urine creatinine were measured perioperatively.


RESULTS
Although the average plasma UTI level did not change significantly, the average urine UTI level per day showed a change similar to that of the average plasma CRP level, reaching a maximum of approximately eight times the preoperative level on the second postoperative day (86,610 +/- 53,109 U/day). The maximum postoperative increase in urine UTI excretion per day (delta-uUTImax) correlated significantly with the maximum increase in CRP and the increase in creatinine clearance. Multiple regression analysis revealed that delta-uUTImax was significantly and positively correlated with the indocyanine green plasma disappearance rate and operation duration, and negatively correlated with the resection rate.


CONCLUSIONS
The postoperative urine UTI level may reflect preoperative liver function and the extent of liver resection after partial hepatectomy.
Noie
T
T
Dept. of Surgery, Graduate School of Medicine, University of Tokyo, Japan.
Sugawara
Y
Y
Harihara
Y
Y
Takayama
T
T
Kubota
K
K
Ohashi
Y
Y
Makuuchi
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002097:C-Reactive Protein / Q000032:analysis*; D005260:Female; D006498:Hepatectomy / Q000379:methods*; D006801:Humans; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000378:metabolism* / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011184:Postoperative Period; D011300:Preoperative Care; D011336:Probability; D011379:Prognosis; D011863:Radioimmunoassay; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D016896:Treatment Outcome; D014361:Trypsin Inhibitors / Q000097:blood / Q000652:urine*
D015415:Biomarkers; D014361:Trypsin Inhibitors; D002097:C-Reactive Protein