Mass spectrometric strategies: providing structural clues for helminth glycoproteins.
Here we review current knowledge of helminth glycans and introduce parasitologists to the power of the mass spectrometric techniques that have been largely responsible for defining their carbohydrate moieties. A brief overview of glycosylation in other eukaryotes is presented, with a focus on mammalian glycosylation, to facilitate understanding of how parasite structures might be recognized as 'self' or 'foreign' by the immune system of the host.
Haslam
S M
SM
Dept of Biochemistry, Imperial College of Science, Technology and Medicine, SW7 2AY., London, UK.
Morris
H R
HR
Dell
A
A
D006023:Glycoproteins / Q000737:chemistry*; D006031:Glycosylation; D015801:Helminth Proteins / Q000737:chemistry*; D013058:Mass Spectrometry / Q000379:methods
D006023:Glycoproteins; D015801:Helminth Proteins