The physiology of corticotropin-releasing hormone deficiency in mice.
A review of the generation and characterization of corticotropin-releasing hormone (CRH)-deficient mice is presented. The studies summarized demonstrate the central role of CRH in the pituitary-adrenal axis response to stress, circadian stimulation, and glucocorticoid withdrawal. Additionally, pro-inflammatory actions of CRH at sites of local inflammation are given further support. In contrast, behavioral effects during stress that had been ascribed to CRH action are not altered in CRH-deficient mice. The normal behavioral response to stress in CRH-deficient mice strongly suggests the importance of other, possibly as yet undiscovered, CRH-like molecules.
Muglia
L J
LJ
Departments of Pediatrics, Molecular Biology and Pharmacology, and Obstetrics and Gynecology, Washington University School of Medicine, and St. Louis Children's Hospital, St. Louis, MO 63110, USA. Muglia_L@kids.wustl.edu
Jacobson
L
L
Weninger
S C
SC
Karalis
K P
KP
Jeong
K
K
Majzoub
J A
JA
D000324:Adrenocorticotropic Hormone / Q000096:biosynthesis / Q000378:metabolism; D000818:Animals; D002940:Circadian Rhythm / Q000502:physiology*; D003346:Corticotropin-Releasing Hormone / Q000172:deficiency* / Q000502:physiology*; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007249:Inflammation / Q000503:physiopathology; D051379:Mice; D018345:Mice, Knockout
D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone