Antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice.
The antinociceptive effect of vitamin K2 (menatetrenone) in diabetic mice was examined using a tail-pressure test. Intraperitoneal injection of menatetrenone (10-100 mg/kg) produced a dose-dependent increase in the nociceptive threshold in diabetic mice. There was no significant difference between non-diabetic and diabetic mice in the menatetrenone-induced changes in the nociceptive threshold. The results suggest the therapeutical usefulness of menatetrenone for treating painful diabetic neuropathy and osteoporosis.
Onodera
K
K
Department of Dental Pharmacology, Okayama University Dental School, Japan. onoderak@md.okayama-u.ac.jp
Zushida
K
K
Kamei
J
J
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D003929:Diabetic Neuropathies / Q000188:drug therapy*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D013623:Tail; D014812:Vitamin K / Q000031:analogs & derivatives / Q000627:therapeutic use*; D024482:Vitamin K 2 / Q000031:analogs & derivatives
D000700:Analgesics; D024482:Vitamin K 2; D014812:Vitamin K; C030814:menatetrenone