Idiopathic thrombocytopenic purpura following successful treatment of acute lymphoblastic leukemia.
Thrombocytopenia is common in patients with acute lymphocytic leukemia (ALL) at diagnosis. It is a universal side effect of dose-intensive regimens employed in the treatment of adult ALL. In patients with ALL who achieve remission, thrombocytopenia frequently indicates relapse. We report three adult patients successfully treated for ALL who developed thrombocytopenia and were found to have immune-mediated thrombocytopenia (ITP). Possible pathophysiologic mechanisms underlying the association of ALL and ITP are discussed.
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Department of Leukemia at the University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.
Kantarjian
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D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects; D018572:Disease-Free Survival; D006801:Humans; D008297:Male; D008875:Middle Aged; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications* / Q000188:drug therapy; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000139:chemically induced* / Q000209:etiology / Q000628:therapy; D013156:Splenectomy; D013256:Steroids
D000893:Anti-Inflammatory Agents; D013256:Steroids