Allelotype frequency of the thiopurine methyltransferase (TPMT) gene in Japanese.
Polymorphisms at three loci in the thiopurine methyltransferase (TPMT) gene are known to be responsible for azathioprine and 6-mercaptopurine (6MP) toxicity. Among them, only TPMT*3C variant allele with A719G mutation was found in 15/522 (2.9%; 17/1044 alleles; 1.6%) Japanese individuals including two homozygotes. The allele frequency was different from that in Caucasians, and investigation of TPMT polymorphisms with consideration of ethnic differences before administration of azathioprine or 6MP may provide clinically useful information.
Kumagai
K
K
Second Department of Internal Medicine, Hiroshima University School of Medicine, 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan.
Hiyama
K
K
Ishioka
S
S
Sato
H
H
Yamanishi
Y
Y
McLeod
H L
HL
Konishi
F
F
Maeda
H
H
Yamakido
M
M
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D017931:DNA Primers / Q000737:chemistry; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008780:Methyltransferases / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D044465:White People / Q000235:genetics
D017931:DNA Primers; D008780:Methyltransferases; C022745:thiopurine methyltransferase