Controlled-release tablets from carrageenans: effect of formulation, storage and dissolution factors.
The purpose of this study was to investigate the potential of two carrageenans, iota-carrageenan and lambda-carrageenan for the preparation of controlled-release tablets. Tablets were compressed on a Carver press and the effect of formulation factors, moisture, and storage on the release of theophylline was studied. The effect of sodium chloride in the tablet formulation and a change in the ionic strength of the dissolution media was studied on the release of three model drugs. The release rate increased both with an increase in tablet diameter and increase in drug to carrageenan ratio in the tablets. The two lubricants studied had a negligible effect on the rate of drug release at their commonly used concentrations. Moisture content of carrageenans, storage of tablets at 37 degrees C/75% RH for 3 months, and incorporation of 10% sodium chloride in the tablets did not have any significant effect on the release rate. The change in ionic strength of simulated gastric fluid altered the release rate whereas the ionic strength of simulated intestinal fluid did not have a significant effect on the release rate. Carrageenan tablets were relatively insensitive to small changes in formulation parameters and dissolution conditions.
Gupta
V K
VK
University of Georgia, College of Pharmacy, Department of Pharmaceutical and Biomedical Sciences, Athens, GA, USA. vishal.k.gupta@pharmacia.com
Hariharan
M
M
Wheatley
T A
TA
Price
J C
JC
D002351:Carrageenan / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004356:Drug Storage; D006813:Humidity; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008153:Lubrication; D009994:Osmolar Concentration; D012965:Sodium Chloride; D013607:Tablets / Q000737:chemistry*
D003692:Delayed-Action Preparations; D013607:Tablets; D012965:Sodium Chloride; D002351:Carrageenan