The role of the dura in conditioned taste avoidance induced by cooling the area postrema of male rats.
Experiments were designed to assess the contribution of the dura mater to the formation of conditioned taste avoidance induced by cooling the area postrema. The results of the first experiment verified that the temperature of the dura showed a temperature gradient at various distances from the tip of the cold probe. In the second and third experiments, a circle of dura was cut away so that different amounts of the area postrema could be cooled without cooling the overlying dura. Cooling the dura plus the area postrema did not produce a stronger avoidance than just cooling the area postrema. In the fourth experiment, the cerebellar cortex was cooled with and without cooling the dura. Cooling the cerebellar cortex produced conditioned taste avoidance, and cooling the dura plus the cerebellar cortex did not produce a stronger avoidance. Taken together, these results suggest that cooling the dura mater does not contribute to the conditioned taste avoidance induced by cooling the area postrema. The results of the fifth experiment showed that cooling the area postrema produced a stronger conditioned taste avoidance than cooling the cerebellar cortex. It is suggested that the avoidance induced by cooling both of these structures is the result of physiological changes occurring when neurons in these structures are inactivated and when the subdural meninges are cooled. Furthermore, these changes are more severe when the area postrema is cooled.
Wang
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Department of Psychology, Seeley G. Mudd Building SGM 501, University of Southern California, Los Angeles, CA 90089-1061, USA. yuwang@rcf.usc.edu
Chambers
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D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D002525:Cerebellar Cortex / Q000033:anatomy & histology / Q000502:physiology; D003080:Cold Temperature; D004388:Dura Mater / Q000033:anatomy & histology / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013395:Sucrose / Q000494:pharmacology; D013649:Taste / Q000502:physiology*
D013395:Sucrose