Effects of Ginkgo biloba extract on somatosensory evoked potential, nitric oxide levels in serum and brain tissue in rats with cerebral vasospasm after subarachnoid hemorrhage.
This study aimed to investigate the protective effects of Ginkgo biloba extract on cerebral vasospasm and neural damage following subarachnoid hemorrhage (SAH) in rats. It was found that the regional cerebral blood flow decreased immediately and persistently after SAH in SAH rats. The latency of somatosensory evoked potential delayed progressively. The nitric oxide levels in serum and brain tissue decreased and increased, respectively, after SAH. Ginkgo biloba extract effectively antagonized the changes of above parameters. It was concluded that somatosensory evoked potential is useful for the judgement of cerebral ischemic damage during cerebral vasospasm after SAH. Decrease in serum nitric oxide and increase in brain tissue nitric oxide are important factors leading to cerebral vasospasm and neural damage, respectively, after SAH. Ginkgo biloba extract relieves cerebral vasospasm and cerebral ischemic damage by reversing the pathological alteration of nitric oxide.
Sun
B L
BL
Institute of Microcirculation, Affiliated Hospital of Taishan Medical College, Taian, Shandong, China. sunb188@263.net
Xia
Z L
ZL
Yang
M F
MF
Qiu
P M
PM
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D001925:Brain Damage, Chronic / Q000209:etiology / Q000517:prevention & control; D002545:Brain Ischemia / Q000209:etiology / Q000517:prevention & control; D004353:Drug Evaluation, Preclinical; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005260:Female; D005419:Flavonoids / Q000494:pharmacology* / Q000627:therapeutic use; D020441:Ginkgo biloba / Q000627:therapeutic use*; D008297:Male; D009569:Nitric Oxide / Q000032:analysis* / Q000097:blood; D008517:Phytotherapy; D010936:Plant Extracts; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time / Q000187:drug effects; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D020301:Vasospasm, Intracranial / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D000096983:Ginkgo Extract
D004365:Drugs, Chinese Herbal; D005419:Flavonoids; D009569:Nitric Oxide; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract