Mitochondrial production of hydrogen peroxide regulation by nitric oxide and the role of ubisemiquinone.
Mitochondria are considered the major cellular site for hydrogen peroxide production, a process that is kinetically controlled by the availability of oxygen and nitric oxide to cytochrome oxidase and of ADP to F1-ATPase. The multisite regulation of mitochondrial respiration and energy-transducing pathways support a critical regulatory role of mitochondrion in cell signaling pathways. The cellular steady-state levels of hydrogen peroxide and the role of mitochondria in maintaining these levels are reviewed.
Boveris
A
A
Department of Physical Chemistry, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina.
Cadenas
E
E
D000818:Animals; D017209:Apoptosis; D003067:Coenzymes; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000378:metabolism*
D003067:Coenzymes; D014451:Ubiquinone; D009569:Nitric Oxide; D006861:Hydrogen Peroxide; C024989:coenzyme Q10