Diagnosis of concurrent hemoglobin H disease and heterozygous beta-thalassemia.
Definitive diagnosis of concurrent hemoglobin (Hb) H disease and heterozygous beta-thalassemia cannot be made from Hb analysis alone, but necessitates genotype analysis and family study. Interactions between alpha- and beta-thalassemia must be considered when investigating moderate to severe hypochromic microcytic anemia of uncertain cause in adult patients from areas with a high prevalence of globin gene mutations.
Ma
E S
ES
Chan
A Y
AY
Au
W Y
WY
Yeung
Y M
YM
Chan
L C
LC
D000328:Adult; D000747:Anemia, Hypochromic / Q000209:etiology; D004252:DNA Mutational Analysis; D005260:Female; D005914:Globins / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D009154:Mutation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic; D017085:alpha-Thalassemia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics; D017086:beta-Thalassemia / Q000150:complications / Q000175:diagnosis* / Q000235:genetics
D005914:Globins