Anti-genotoxicity of galangin as a cancer chemopreventive agent candidate.
Flavonoids are polyphenolic compounds that are present in plants. They have been shown to possess a variety of biological activities at non-toxic concentrations in organisms. Galangin, a member of the flavonol class of flavonoid, is present in high concentrations in medicinal plants (e.g. Alpinia officinarum) and propolis, a natural beehive product. Results from in vitro and in vivo studies indicate that galangin with anti-oxidative and free radical scavenging activities is capable of modulating enzyme activities and suppressing the genotoxicity of chemicals. These activities will be discussed in this review. Based on our review, galangin may be a promising candidate for cancer chemoprevention.
Heo
M Y
MY
College of Pharmacy, Kangwon National University, Chunchon 200, South Korea. h0858my@hanmail.net
Sohn
S J
SJ
Au
W W
WW
D000477:Alkylating Agents / Q000037:antagonists & inhibitors; D000818:Animals; D016588:Anticarcinogenic Agents / Q000737:chemistry / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000737:chemistry / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D002273:Carcinogens / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D051546:Cyclooxygenase 2; D018736:DNA Adducts / Q000187:drug effects; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D008565:Membrane Proteins; D009369:Neoplasms / Q000517:prevention & control*; D011084:Polycyclic Aromatic Hydrocarbons / Q000037:antagonists & inhibitors; D011451:Prostaglandin-Endoperoxide Synthases; D011837:Radiation-Protective Agents / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000477:Alkylating Agents; D016588:Anticarcinogenic Agents; D016587:Antimutagenic Agents; D000975:Antioxidants; D002273:Carcinogens; D018736:DNA Adducts; D005419:Flavonoids; D007527:Isoenzymes; D008565:Membrane Proteins; D011084:Polycyclic Aromatic Hydrocarbons; D011837:Radiation-Protective Agents; C037032:galangin; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases