Cellular trafficking in trypanosomatids: a new target for therapies?
Pathogenic trypanosomatids cause a plethora of diseases marked by the lack of efficient vaccines and therapies. As a consequence, studies are being conducted that are geared towards the understanding of basic mechanisms and various biological aspects of these parasites that might be used as targets for new developments in these areas. One such aspect is the understanding of specific cellular trafficking mechanisms that might be attacked with the intention of disease control. In this paper, we give an overview of our current knowledge of cellular targeting mechanisms in trypanosomatids, with special emphasis on our data related to lysosomal targeting of cysteine proteinases in Leishmania.
Costa-Pinto
D
D
Department of Biochemistry and Molecular Biology, Oswaldo Cruz Institute, FIOCRUZ, Av. Brasil 4365, RJ 21045-900, Rio de Janeiro, Brazil.
Trindade
L S
LS
McMahon-Pratt
D
D
Traub-Cseko
Y M
YM
D000818:Animals; D000981:Antiprotozoal Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D003546:Cysteine Endopeptidases / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D005786:Gene Expression Regulation; D049452:Green Fluorescent Proteins; D007891:Leishmania / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D007896:Leishmaniasis / Q000188:drug therapy; D008164:Luminescent Proteins / Q000235:genetics / Q000493:pharmacokinetics; D008247:Lysosomes / Q000201:enzymology; D008856:Microscopy, Fluorescence; D011993:Recombinant Fusion Proteins / Q000493:pharmacokinetics; D014345:Trypanosoma / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D014353:Trypanosomiasis, African / Q000188:drug therapy
D000981:Antiprotozoal Agents; D008164:Luminescent Proteins; D011993:Recombinant Fusion Proteins; D049452:Green Fluorescent Proteins; D003546:Cysteine Endopeptidases