title: Recurrent disseminated retinoblastoma in a 7-year-old girl treated successfully by high-dose chemotherapy and CD34-selected autologous peripheral blood stem cell transplantation.
abstract: A localized retinoblastoma of the left eye in a 7-year-old girl, was treated by enucleation. She received no additional therapy. Four months later, metastases of retinoblastoma in the lymph nodes, bone and bone marrow were diagnosed. Relapse chemotherapy consisting of three courses of vincristine, cyclophosphamide, etoposide and carboplatin led to a second complete remission. Subsequent high-dose chemotherapy with thiotepa, etoposide and carboplatin and autologous stem cell transplantation with CD34-selected stem cells were successful, with no adverse effects. No radiotherapy was given and the girl remains in continuous second remission with a follow-up of more than 4 years.
authors.affiliation: University Hospital for Children and Adolescents, Friedrich-Alexander University of Erlangen-Nürnberg, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Hertzberg
authors.forename: B
authors.initials: B
authors.lastname: Kremens
authors.forename: I
authors.initials: I
authors.lastname: Velten
authors.forename: J D
authors.initials: JD
authors.lastname: Beck
authors.forename: J
authors.initials: J
authors.lastname: Greil
mesh_terms: D018952:Antigens, CD34 / Q000097:blood; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D019046:Bone Marrow Neoplasms / Q000556:secondary; D001859:Bone Neoplasms / Q000556:secondary; D016190:Carboplatin / Q000008:administration & dosage; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D012008:Recurrence; D012074:Remission Induction; D012175:Retinoblastoma / Q000188:drug therapy* / Q000473:pathology; D013852:Thiotepa / Q000008:administration & dosage; D014182:Transplantation, Autologous / Q000276:immunology; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D018952:Antigens, CD34; D000970:Antineoplastic Agents; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D013852:Thiotepa; D016190:Carboplatin