title: Molecular pathogenesis of Citrobacter rodentium and transmissible murine colonic hyperplasia.
abstract: Here we review the history, clinical significance, pathology and molecular pathogenesis of Citrobacter rodentium, the causative agent of transmissible murine colonic hyperplasia. C. rodentium serves as an important model pathogen for investigating the mechanisms controlling attaching and effacing pathology, epithelial hyperproliferation, and tumor promotion in the distal colon of the mouse.
authors.affiliation: Division of Bioengineering and Environmental Health, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 56-787B, Cambridge, Massachusetts 02139, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Luperchio
authors.forename: D B
authors.initials: DB
authors.lastname: Schauer
mesh_terms: D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism; D016971:Citrobacter freundii / Q000235:genetics / Q000472:pathogenicity*; D003043:Cocarcinogenesis; D003106:Colon / Q000382:microbiology / Q000473:pathology*; D003108:Colonic Diseases / Q000382:microbiology / Q000473:pathology*; D003110:Colonic Neoplasms / Q000209:etiology; D004195:Disease Models, Animal; D004756:Enterobacteriaceae Infections / Q000382:microbiology / Q000473:pathology*; D006801:Humans; D006965:Hyperplasia; D051379:Mice; D014774:Virulence / Q000235:genetics
chemical_list: D001426:Bacterial Proteins