The alpha2 Gene alleles of the platelet collagen receptor integrin alpha2 beta1 in Turkish children with cerebral infarct.
The possible role of point mutations in the platelet integrin alpha2 beta1 gene in Turkish children with ischemic stroke was evaluated in this study. The case-control study included 44 pediatric patients with cerebral infarct (age range, 10 months to 18 years) and 96 healthy unrelated individuals. Genotyping was performed according to previously described methods. Distribution of the three haplotypes were 36.4%, 45.3%, 10.4% and 31.8%, 50.0%, 13.6% for the controls and the patients, respectively. A new fourth haplotype was found which was 7.8% and 4.5% respectively. Our data indicated that these haplotypes are not risk factors in pediatric stroke group.
Akar
N
N
Department of Pediatric Molecular Genetics, Ankara University, Ankara, Turkey. nejat_akar@hotmail.com
Duman
T
T
Akar
E
E
Deda
G
G
Sipahi
T
T
D000293:Adolescent; D000483:Alleles; D016022:Case-Control Studies; D002544:Cerebral Infarction / Q000209:etiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007223:Infant; D016023:Integrins / Q000235:genetics*; D010980:Platelet Membrane Glycoproteins / Q000235:genetics; D038981:Receptors, Collagen; D014421:Turkey / Q000453:epidemiology
D016023:Integrins; D010980:Platelet Membrane Glycoproteins; D038981:Receptors, Collagen