title: Sesquiterpenes and monoterpenes from the bark of Inula macrophylla.
abstract: Eleven new sesquiterpenes (1--11) and two thymol derivatives (12, 13), along with 12 known sesquiterpenes and monoterpenes, were isolated from the bark of Inula macrophylla. Their structures were determined on the basis of spectral evidence (especially by HREIMS and 2D NMR) as well as chemical transformations. The structure of macrophyllic acid A (1) was confirmed by X-ray analysis, and the absolute configuration of 1 was determined on the basis of the appropriate chemical conversions and the application of a modified Mosher's method.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
authors.forename: B N
authors.initials: BN
authors.lastname: Su
authors.forename: Y
authors.initials: Y
authors.lastname: Takaishi
authors.forename: T
authors.initials: T
authors.lastname: Yabuuchi
authors.forename: T
authors.initials: T
authors.lastname: Kusumi
authors.forename: M
authors.initials: M
authors.lastname: Tori
authors.forename: S
authors.initials: S
authors.lastname: Takaoka
authors.forename: G
authors.initials: G
authors.lastname: Honda
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Takeda
authors.forename: O K
authors.initials: OK
authors.lastname: Kodzhimatov
authors.forename: O
authors.initials: O
authors.lastname: Ashurmetov
mesh_terms: D018360:Crystallography, X-Ray; D038143:Inula / Q000737:chemistry*; D008958:Models, Molecular; D015394:Molecular Structure; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013057:Spectrum Analysis; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification*
chemical_list: D012717:Sesquiterpenes; D013729:Terpenes