Relation between 1H MR spectroscopic imaging and regional cerebral glucose metabolism in Alzheimer's disease.
1 H Magnetic resonance spectroscopic imaging (MRSI) and positron emission tomography (PET) of (18) F-2-fluoro-2-deoxy-D-glucose (FDG) were performed in 18 patients with probable Alzheimer's disease (AD) and 3 normal controls. We measured the distribution and relative signal intensities of N-acetyl aspartate (NAA; a presumed neuronal marker), choline residues (Cho) representing cellular membrane compounds and of creatine-containing metabolites (Cr), and correlated these to regional cerebral glucose metabolism (rCMRGI) after coregistration of both imaging-techniques. The pattern of choline was significantly different between AD and normals (p < 0.01). RCMRGI was significantly related to Cho/Cr (r=-0.21, p<.05) and NAA/Cho quotients (r=0.35, p<.001). Our results suggest that in AD reduced neuronal energy performance and membrane abnormalities contribute to metabolic deterioration.
Mielke
R
R
Max-Planck Institute for Neurological Research, Gleueler Str. 50, D-50931 Köln, Germany. ruediger.mielke@pet.mpin-koeln.mpg.de
Schopphoff
H H
HH
Kugel
H
H
Pietrzyk
U
U
Heindel
W
W
Kessler
J
J
Heiss
W D
WD
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000000981:diagnostic imaging / Q000378:metabolism*; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002794:Choline / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D014055:Tomography, Emission-Computed
D001224:Aspartic Acid; C000179:N-acetylaspartate; D005947:Glucose; D002794:Choline