Chemistry and bioactivity of Raulinoa echinata Cowan, an endemic Brazilian Rutaceae species.
The hexane extract of the stems of Raulinoa echinata afforded the sesquiterpenes germacrene D (6), 1beta,6alpha-dihydroxy-4-(15)-eudesmene (4) and oplopanone (5); the triterpenes squalene, isomultiflorenol (7), isobauerenol (8) and friedelin (9); the protolimonoids melianone (2) and melianodiol (3); and the pyranocoumarin 3-(1'-1'-dimethylallyl)-lomatin (1), which has not been reported previously as a natural product; together with beta-sitosterol. The hexane extract and some of these compounds were assayed in vitro against trypomastigote forms of Trypanosoma cruzi. Brine shrimp lethality and antimicrobial activities of the crude extract and pure compounds were also evaluated.
Biavatti
M W
MW
Departamento de Química, Universidade Federal de São Carlos, SP, Brazil. maique@dq.ufscar.br
Vieira
P C
PC
da Silva MFG
Fernandes
J B
JB
Albuquerque
S
S
Magalhães
C M
CM
Pagnocca
F C
FC
D000818:Animals; D001156:Artemia; D001681:Biological Assay; D001938:Brazil; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D019448:Ethnobotany; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018547:Plant Stems; D010946:Plants, Medicinal; D019685:Rosales / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014344:Trypanocidal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000469:parasitology
C434110:3-(1'-1'-dimethylallyl)lomatin; D003374:Coumarins; D010936:Plant Extracts; D012717:Sesquiterpenes; D014315:Triterpenes; D014344:Trypanocidal Agents; C434111:melianodiol; C434112:melianone