title: Combined mechanical and antibiotic periodontal therapy in a case of Papillon-Lefèvre syndrome.
abstract: BACKGROUND
  Papillon Lefèvre syndrome (PLS) is a rare entity and, as such, it is almost impossible to evaluate an effective therapy in a randomized controlled study. The amount of success reported after therapy for prepubertal periodontitis (PP) in PLS is highly variable from case to case. The goal of this case report is to evaluate the effects of a combined mechanical and antibiotic periodontal therapy regimen in the management of PLS.
  
  
  METHODS
  A male patient was diagnosed as suffering from PP associated with PLS at the age of 7 years. He showed hyperkeratosis of the palms and soles, as well as advanced periodontal disease already affecting permanent teeth with maximal probing depth and vertical attachment loss of 12 mm and 11 mm, respectively. Subgingival debridement was performed with simultaneous administration of oral 250 mg amoxicillin 3 times daily and 250 mg metronidazole twice daily for one week. Clinical parameters were assessed and subgingival plaque was collected from all teeth prior to therapy and 7 and 26 months after treatment. Selective cultures for A. actinomycetemcomitans were incubated for each individual tooth and DNA probe analysis was performed for various periodontal pathogens.
  
  
  RESULTS
  Prior to combined mechanical and antibiotic treatment, all teeth but one harbored Actinobacillus actinomycetemcomitans subgingivally. However, at 7 and 26 months after therapy A. actinomycetemcomitans could be detected neither by culture nor by DNA probes. Clinical parameters improved markedly and teeth erupting after therapy did not exhibit attachment loss of more than 1.5 mm during the observation period.
  
  
  CONCLUSIONS
  Eradication (suppression beneath detection levels) of A. actinomycetemcomitans seems to play a significant role in the successful treatment of localized prepubertal periodontitis in PLS.
authors.affiliation: Department of Operative Dentistry and Periodontology, School of Dental Medicine, Ruprecht-Karls-University Heidelberg, Heidelberg, Germany. peter_eickholz@med.uni-heidelberg.de
authors.forename: P
authors.initials: P
authors.lastname: Eickholz
authors.forename: B
authors.initials: B
authors.lastname: Kugel
authors.forename: S
authors.initials: S
authors.lastname: Pohl
authors.forename: H
authors.initials: H
authors.lastname: Näher
authors.forename: H J
authors.initials: HJ
authors.lastname: Staehle
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects / Q000254:growth & development; D010520:Aggressive Periodontitis / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy*; D000658:Amoxicillin / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002648:Child; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology / Q000628:therapy; D012534:Dental Scaling; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D010214:Papillon-Lefevre Disease / Q000150:complications*; D010406:Penicillins / Q000627:therapeutic use*; D017622:Periodontal Attachment Loss / Q000188:drug therapy / Q000628:therapy; D010514:Periodontal Pocket / Q000188:drug therapy / Q000628:therapy; D011627:Puberty; D016745:Root Planing; D013357:Subgingival Curettage
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D008795:Metronidazole; D000658:Amoxicillin