title: Non-Hodgkin's lymphoma subtypes over time in an unselected population of 646 patients: a study of clinico-pathological data and incidence based on a review using the REAL-classification.
abstract: Biopsies from 646 consecutive unselected cases of non-Hodgkin's lymphoma from a Danish population-based registry were reclassified according to the REAL classification 1) to study the distribution of subtypes over time, and 2) to correlate a number of clinical parameters with the various subtypes. Two cohorts from 1986 and 1992, of 292 and 354 cases, respectively, were studied. From 1986 to 1992 diffuse large B-cell lymphoma showed a change in incidence of + 43.1%, as opposed + 2.5% for all other subtypes combined (p = 0.05), suggesting that the increasing general incidence of non-Hodgkin's lymphoma is due primarily to an increasing incidence of diffuse large B-cell lymphoma. A higher rate of cell proliferation was associated with an increasing chance of having extranodal disease. For the various subgroups there was good agreement between survival and the International prognostic index.
authors.affiliation: Department of Hematology, Odense University Hospital, Denmark.
authors.forename: H
authors.initials: H
authors.lastname: Brincker
authors.forename: N T
authors.initials: NT
authors.lastname: Pedersen
authors.forename: K
authors.initials: K
authors.lastname: Bendix-Hansen
authors.forename: P
authors.initials: P
authors.lastname: Johansen
mesh_terms: D019046:Bone Marrow Neoplasms / Q000473:pathology; D015331:Cohort Studies; D015981:Epidemiologic Factors; D006801:Humans; D015994:Incidence; D008198:Lymph Nodes / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000453:epidemiology / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000453:epidemiology / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000453:epidemiology* / Q000473:pathology; D011379:Prognosis; D012042:Registries; D013160:Splenic Neoplasms / Q000473:pathology; D015996:Survival Rate; D013997:Time Factors