title: Malignant potential of positive peritoneal cytology in endometrial cancer.
abstract: OBJECTIVE
  To investigate the malignant potential of positive peritoneal cytology in endometrial cancer.
  
  
  METHODS
  Fifty patients with clinical stage I-II endometrial cancer in whom the disease was completely surgically resected and positive peritoneal smears were found at surgery formed the study population. In these patients, a tube for cytologic analyses was inserted into the peritoneal cavity when closing the abdomen. The peritoneal cavity was irrigated with physiologic saline, and washings were obtained through the tube 7 and 14 days after the operation.
  
  
  RESULTS
  Persistence of positive peritoneal cytology was observed in four of seven patients with adnexal metastasis, zero of nine patients with nodal disease, and one of 34 patients with disease confined to the uterus, for a total of 10% (5 of 50). In the remaining 45 (90%) patients, no malignant cells were found in any of the washings.
  
  
  CONCLUSIONS
  The current series suggests that endometrial cancer cells found in the peritoneal cavity usually disappear within a short time and seem to have a low malignant potential. It also seems that only malignant cells from special cases, such as adnexal metastasis, may be capable of independent growth, and are possibly associated with intraperitoneal recurrence.
authors.affiliation: Department of Gynecology, Cancer Institute Hospital, Tokyo, Japan. yhirai@jfcr.or.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Hirai
authors.forename: N
authors.initials: N
authors.lastname: Takeshima
authors.forename: T
authors.initials: T
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Hasumi
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D005833:Genital Neoplasms, Female / Q000556:secondary; D006801:Humans; D008875:Middle Aged; D009367:Neoplasm Staging; D010529:Peritoneal Cavity / Q000473:pathology*; D010533:Peritoneal Lavage; D011379:Prognosis; D012680:Sensitivity and Specificity