Trovafloxacin hepatotoxicity.
A 19-year-old woman was treated for recurrent sinusitis with oral trovafloxacin and developed acute hepatitis and peripheral eosinophilia, with hepatosplenomegaly and ascites. Laparoscopic liver biopsy showed extensive centrilobular hepatocyte necrosis, likely causing venooclusive disease-like signs and symptoms. Clinical and laboratory abnormalities resolved completely after prolonged treatment with steroids. The temporal relationship between trovafloxacin and the onset of hepatitis favors this drug as a culprit.
Lazarczyk
D A
DA
William Beaumont Hospital, Division of Gastroenterology-Hepatology, Royal Oak, Michigan 48073, USA.
Goldstein
N S
NS
Gordon
S C
SC
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D009287:Naphthyridines / Q000009:adverse effects*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C080163:trovafloxacin