title: [Relations of acid-base balance and gastric secretion of hydrogen carbonate ions in patients with peptic ulcer].
abstract: OBJECTIVE
  To study acid-base balance (ABB) of the organism, gastric secretion of hydrocarbonate (HCO3-) in ulcer patients and to examine their relationships.
  
  
  METHODS
  ABB in capillary or venous blood before and after losec and famotidine treatment and gastric secretion of HCO3- were studied in 72 patients with ulcer.
  
  
  RESULTS
  It was found that patients with gastroduodenal ulcer have metabolic, less frequently hypercapnic acidosis with suppressed gastric secretion of HCO3-. This entails abnormal neutralization of the hydrochloric acid imitating high acidity of the gastric juice. HCO3- secretion is inversely proportional to pH. H2-blockers normalize ABB in ulcer patients while losec either stimulates acidosis or transforms one kind of acidosis into another.
  
  
  CONCLUSIONS
  ABB and gastric secretion of HCO3- are related. Acidosis in ulcer patients leads to reduction of HCO3- production and intensification of hydrochloric acid secretion.
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Malov
authors.forename: A N
authors.initials: AN
authors.lastname: Kulikov
authors.forename: T G
authors.initials: TG
authors.lastname: Ivashkina
mesh_terms: D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000503:physiopathology; D000328:Adult; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001639:Bicarbonates / Q000378:metabolism*; D015738:Famotidine / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000008:administration & dosage / Q000627:therapeutic use; D010437:Peptic Ulcer / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000897:Anti-Ulcer Agents; D001639:Bicarbonates; D015738:Famotidine; D009853:Omeprazole