Design and synthesis of novel chiral dendritic species derived from bile acids.
Bile acids have been used for the first time as the building block for the construction of dendritic units. Orthogonally functionalized 7-deoxycholic and cholic acid derivatives were synthesized. The construction of a bile acid heptamer, a nonamer, and a decamer using the convergent strategy are described in detail. Chromatographic, spectral, and optical properties of these molecules have been investigated. Molecular modeling suggests that these molecules have globular shapes with nanometric dimensions.
Balasubramanian
R
R
Department of Organic Chemistry, Indian Institute of Science, Bangalore 560 012, India.
Maitra
U
U
D001647:Bile Acids and Salts / Q000737:chemistry*; D019826:Cholic Acid / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D003840:Deoxycholic Acid / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008970:Molecular Weight; D011108:Polymers / Q000138:chemical synthesis; D013056:Spectrophotometry, Ultraviolet
D001647:Bile Acids and Salts; D011108:Polymers; D003840:Deoxycholic Acid; D019826:Cholic Acid