Gout: can management be improved?
Ongoing reviews of Cochrane collaboration show that there is still very little reliable information based on randomized controlled trials on which to base treatment decisions in acute and chronic gout. Recent studies have stressed that avoidance of factors contributing to development of gouty attacks such as diuretic therapy, weight gain, and alcohol consumption may lead to a decrease in gouty arthritis. Attention to minidose aspirin and its effect on serum uric acid levels was addressed. A low carbohydrate, high protein and unsaturated fat diet was recommended for gouty patients since they all enhance insulin sensitivity and therefore may promote a reduction in serum uric acid levels. Treatment of gout in transplant recipients brings into focus some of the issues regarding management of gout, because gout is a common problem among transplant patients.
Schlesinger
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Section of Rheumatology, UMDNJ/New Jersey Medical School, Newark, New Jersey 07103-2714, USA. schlesna@umdnj.edu
Schumacher
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HR
D000208:Acute Disease; D015984:Causality; D016572:Cyclosporine / Q000009:adverse effects; D006073:Gout / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D006074:Gout Suppressants / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D014527:Uric Acid / Q000378:metabolism
D006074:Gout Suppressants; D007166:Immunosuppressive Agents; D014527:Uric Acid; D016572:Cyclosporine