Protective action of piperine against experimental gastric ulcer.
OBJECTIVE
To study the effects of piperine (Pip) on several experimental gastric ulcers in rats and mice.


METHODS
The gastric mucosa damage was induced by stress, indometacin, HCl, and pyloric ligation in rats or mice. The number of gastric ulcers, the volume and acidity of gastric juices, and pepsin A activity were detected.


RESULTS
Pip 25, 50, 100 mg/kg ig protected animals from gastric ulceration in a dose-dependent manner. The inhibitory rates were 16.9%, 36.0%, and 48.3% in stress ulcers; 4.4%, 51.1%, and 64.4% in indometacin ulcers; 19.2%, 41.5%, and 59.6% in HCl ulcers; 4.8%, 11.9%, and 26.2% in pyloric ligation ulcers, respectively; Pip inhibited the volume of gastric juice, gastric acidity, and pepsin A activity.


CONCLUSIONS
Pip has the protective effects against gastric ulceration.
Bai
Y F
YF
Inner Mongol Institute of Traditional Chinese-Mongol Medicine, Huhehaote 010020, China.
Xu
H
H
D000470:Alkaloids; D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D052117:Benzodioxoles; D004305:Dose-Response Relationship, Drug; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051379:Mice; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides; D051381:Rats; D013276:Stomach Ulcer / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control; D014443:Tyrosine / Q000378:metabolism
D000470:Alkaloids; D000897:Anti-Ulcer Agents; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D014443:Tyrosine; C008922:piperine