Effects of naturally occurring glucosides, solasodine glucosides, ginsenosides and parishin derivatives on multidrug resistance of lymphoma cells and leukocyte functions.
Solamargine, solasonine, ginsenosides and parishin-related compounds were investigated for their effects on mdr efflux pump of lymphoma cells, and their effects on T cell proliferative assays and cell mediated immune functions, antibody-dependent cellular cytotoxicity (ADCC) and natural killer (NK) cell activity of human peripheral mononuclear cells. Solamargine and solasonine were the only drugs which inhibited all of the tested immune functions; however, ginsenoside Rc and Rd enhanced T cell proliferative assays and marginally increased the NK cell activity. The majority of the compounds were not able to reverse the multidrug resistance of mouse lymphoma cells. However, ginsenosides Rc, Rd and parishin C were able to moderately reduce the activity of the efflux pump. Parishin, parishin C and crude extract significantly enhanced the ADCC reaction.
Berek
L
L
Institute of Microbiology, University of Szeged, Faculty of Medicine, Dom ter 10, 6720 Szeged, Hungary.
Szabó
D
D
Petri
I B
IB
Shoyama
Y
Y
Lin
Y H
YH
Molnár
J
J
D000818:Animals; D004305:Dose-Response Relationship, Drug; D018432:Drug Resistance, Multiple; D019008:Drug Resistance, Neoplasm; D036145:Ginsenosides; D005960:Glucosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000187:drug effects; D008213:Lymphocyte Activation / Q000187:drug effects*; D016399:Lymphoma, T-Cell; D051379:Mice; D012503:Saponins / Q000737:chemistry / Q000494:pharmacology*; D012991:Solanaceous Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D036145:Ginsenosides; D005960:Glucosides; D012503:Saponins; D012991:Solanaceous Alkaloids; C012037:solasodine