A maternal inherited translocation t(1;22)(q11;p11) in two infertile brothers.
We report two infertile brothers presenting with azoospermia and oligozoospermia. Cytogenetic studies using G-banding and FISH analysis on lymphocyte cultures revealed an autosomal balanced reciprocal translocation t(1;22)(q11;p11) in both males. The same translocation was found in their mother, but not in a third fertile brother and maternal uncle suggesting that this translocation might compromise the male but not the female gametogenesis in this family.
Lorda-Sanchez
I
I
Department of Genetics, Fundación Jimenez-Diaz, Madrid, Spain.
Tejedor
C
C
Sanz
R
R
Rodriguez de Alba
M
M
de la Fuente
A
A
Fernandez
E
E
Ayuso
C
C
Ramos
C
C
D000328:Adult; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D008297:Male; D009035:Mothers; D009845:Oligospermia / Q000235:genetics*; D010375:Pedigree; D014178:Translocation, Genetic