A simple synthetic route to the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine for the fabrication of functionalized, degradable structures for biomedical applications.
This article documents the formation of a block copolymer of poly(lactic-co-glycolic acid) and polylysine via a simple coupling technique using dicyclohexyl carbodiimide (DCC). The resulting polymer has been characterized via UV-Vis spectroscopy, GPC, (1)H NMR, and elemental analysis, is soluble in a wide variety of solvents, and is easily processable, making the technique a simple and practical one for the formation of functionalized, degradable block copolymers for the fabrication of functionalized structures for biomedical applications.
Lavik
E B
EB
Department of Materials Science and Engineering, Massachusetts Institute of Technology, E25-342, Cambridge, Massachusetts 02139, USA.
Hrkach
J S
JS
Lotan
N
N
Nazarov
R
R
Langer
R
R
D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D001673:Biodegradation, Environmental; D002850:Chromatography, Gel; D004024:Dicyclohexylcarbodiimide; D066298:In Vitro Techniques; D019344:Lactic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008422:Materials Testing; D011100:Polyglycolic Acid / Q000138:chemical synthesis* / Q000737:chemistry; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011107:Polylysine / Q000138:chemical synthesis* / Q000737:chemistry; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D001672:Biocompatible Materials; D011108:Polymers; D000077182:Polylactic Acid-Polyglycolic Acid Copolymer; D011107:Polylysine; D011100:Polyglycolic Acid; D019344:Lactic Acid; D004024:Dicyclohexylcarbodiimide