Comparison of plasma component levels in four strains of female mice with different mammary tumour potentials.
Based on the importance of general metabolic activity to mammary tumourigenesis, plasma component levels were examined at 6 and 10 months of age in female virgin mice of four strains, which in mammary tumour potential, rank in the descending order of SHN, GR/A, SLN and C3H/He. The plasma aspartate aminotransferase level elevated from 6 to 10 months of age in the SHN and GR/A, but not in the SLN and C3H/He strains. The total bilirubin level was higher in the former two strains than the latter two at both 6 and 10 months. The blood urea nitrogen level was highest in SHN. C3H/He had the lowest plasma levels of these components as well as amylase at both ages. The results indicate the signifcance to the mammary tumourigenic potential of plasma levels of certain components related to general metabolic activity.
Nagasawa
H
H
Experimental Animal Research Laboratory, Meiji University, Tama-ku, Kawasaki 214-8571, Japan.
Kusakawa
S
S
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000681:Amylases / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000032:analysis; D001663:Bilirubin / Q000097:blood; D001786:Blood Glucose; D001798:Blood Proteins / Q000032:analysis*; D001806:Blood Urea Nitrogen; D001835:Body Weight; D002118:Calcium / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003404:Creatinine / Q000097:blood; D004326:Drinking; D004435:Eating; D005260:Female; D005916:Globulins / Q000032:analysis; D008325:Mammary Neoplasms, Experimental / Q000097:blood*; D051379:Mice; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D012709:Serum Albumin / Q000032:analysis; D013045:Species Specificity
D001786:Blood Glucose; D001798:Blood Proteins; D005916:Globulins; D012709:Serum Albumin; D002784:Cholesterol; D003404:Creatinine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D000681:Amylases; D001663:Bilirubin; D002118:Calcium