Varicella-zoster virus with a lost gE epitope: evidence for immunological pressure by the human antibody response.
The varicella-zoster virus (VZV) genome contains about 70 open reading frames (ORF). ORF 68 codes for glycoprotein gE, formerly called gpl, which is the predominant VZV glycoprotein; gE is a typical type 1 transmembrane protein with 623 amino acids. Recently, a variant virus was discovered which has a mutation in gE codon 150; this mutation converts an aspartic acid into an asparagine residue.
Padilla
J A
JA
Department of Microbiology & Pediatrics, University of Iowa, Iowa City, USA.
Grose
C
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D000328:Adult; D000595:Amino Acid Sequence; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D000918:Antibody Specificity; D000940:Antigenic Variation / Q000235:genetics* / Q000276:immunology; D000956:Antigens, Viral / Q000235:genetics* / Q000276:immunology; D002644:Chickenpox / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000821:virology; D002648:Child; D003602:Cytotoxicity, Immunologic / Q000276:immunology; D018985:Epitopes, B-Lymphocyte / Q000235:genetics* / Q000276:immunology; D006562:Herpes Zoster / Q000097:blood / Q000276:immunology / Q000473:pathology / Q000821:virology; D014645:Herpesvirus 3, Human / Q000235:genetics* / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D015531:Radioimmunoprecipitation Assay; D014407:Tumor Cells, Cultured; D014759:Viral Envelope Proteins / Q000235:genetics* / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D018985:Epitopes, B-Lymphocyte; D014759:Viral Envelope Proteins; C056913:glycoprotein E, varicella-zoster virus