Influence of new monoterpene homologues of GABA on the central nervous system activity in mice.
This behavioral study in mice showed that the monoterpene homologues of GABA (SL-1, SL-2 and SL-3), characterized by low toxicity, induced an increase in spontaneous locomotor activity (SL-2 and SL-3). Moreover, SL-3 shortened hexobarbital-induced sleeping time, and SL-1 showed anticonvulsant activity in pentetrazole-induced seizures.
Librowski
T
T
Department of Pharmacodynamics, Medical College, Jagiellonian University, Kraków, Poland. mflibrow@kinga.cyf-kr.edu.pl
Czarnecki
R
R
Mendyk
A
A
Jastrzebska
M
M
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D003292:Convulsants; D004305:Dose-Response Relationship, Drug; D006591:Hexobarbital / Q000494:pharmacology; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D019581:Neuropil / Q000187:drug effects; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D012890:Sleep / Q000187:drug effects; D013729:Terpenes / Q000494:pharmacology* / Q000633:toxicity; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000927:Anticonvulsants; D003292:Convulsants; D006993:Hypnotics and Sedatives; D013729:Terpenes; D005680:gamma-Aminobutyric Acid; D006591:Hexobarbital; D010433:Pentylenetetrazole