title: Could platelet activating factor play a role in developmental dyslexia?
abstract: Post-mortem studies by Galaburda and colleagues on the brains of developmental dyslexics found characteristic neuronal abnormalities: ectopias, microgyria, and fewer large-soma cells in sensory thalamus. An association between dyslexia and immune dysfunction has also been proposed. We describe a mechanism which may explain these observations. Platelet-activating factor (PAF) is a pro-inflammatory lipid implicated in neurological disorders. We propose that PAF may also be involved in dyslexia.
authors.affiliation: University of Oxford, UK. Kathleen.taylor@physiol.ox.ac.uk
authors.forename: K E
authors.initials: KE
authors.lastname: Taylor
authors.forename: A J
authors.initials: AJ
authors.lastname: Richardson
authors.forename: J F
authors.initials: JF
authors.lastname: Stein
mesh_terms: D001921:Brain / Q000002:abnormalities / Q000378:metabolism; D004410:Dyslexia / Q000209:etiology* / Q000235:genetics / Q000473:pathology*; D008040:Genetic Linkage; D006801:Humans; D010972:Platelet Activating Factor / Q000096:biosynthesis / Q000502:physiology*
chemical_list: D010972:Platelet Activating Factor