Zeamatin inhibits trypsin and alpha-amylase activities.
Zeamatin is a 22-kDa protein isolated from Zea mays that has antifungal activity against human and plant pathogens. Unlike other pathogenesis-related group 5 proteins, zeamatin inhibits insect alpha-amylase and mammalian trypsin activities. It is of clinical significance that zeamatin did not inhibit human alpha-amylase activity and inhibited mammalian trypsin activity only at high molar concentrations.
Schimoler-O'Rourke
R
R
Mycologics, Inc., Denver, CO 80262, USA.
Richardson
M
M
Selitrennikoff
C P
CP
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001407:Bacillus / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D010179:Pancreas / Q000201:enzymology; D010940:Plant Proteins / Q000494:pharmacology*; D012463:Saliva / Q000201:enzymology; D013552:Swine; D014231:Tribolium / Q000201:enzymology; D014357:Trypsin / Q000378:metabolism*; D014361:Trypsin Inhibitors / Q000494:pharmacology; D003313:Zea mays / Q000201:enzymology; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D010940:Plant Proteins; D014361:Trypsin Inhibitors; C073468:zeamatin protein, Zea mays; D000516:alpha-Amylases; D014357:Trypsin