title: Clinical activity of the new triazole drug voriconazole (UK 109, 496) against disseminated hepatosplenic aspergillosis in a patient with relapsed leukemia.
abstract: There is presently a limited antifungal armamentarium comprising amphotericin and the azoles, fluconazole and itraconazole. In vitro studies have shown efficacy of the new drug, voriconazole, against a wide range of fungi, including most species of Candida and Aspergillus. We review here a case report of a young boy with acute myeloid leukemia who developed disseminated hepatosplenic aspergillosis. He failed therapy with itraconazole, amphotericin B and liposomal amphotericin. As he also had relapsed leukemia, there was a great urgency to control this infection in order to facilitate the administration of cancer chemotherapy. Voriconazole was given with good response resulting in virtual disappearance of all scan evidence of aspergillosis.
authors.affiliation: Department of Haematology, Singapore General Hospital.
authors.forename: Y K
authors.initials: YK
authors.lastname: Hwang
authors.forename: N H
authors.initials: NH
authors.lastname: Joo
authors.forename: G Y
authors.initials: GY
authors.lastname: Tee
authors.forename: P
authors.initials: P
authors.lastname: Tan
authors.forename: L
authors.initials: L
authors.lastname: Tan
authors.forename: R
authors.initials: R
authors.lastname: Girija
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy* / Q000209:etiology*; D002648:Child; D006801:Humans; D007165:Immunosuppression Therapy; D007951:Leukemia, Myeloid / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy / Q000209:etiology; D008297:Male; D011743:Pyrimidines / Q000627:therapeutic use*; D013158:Splenic Diseases / Q000188:drug therapy / Q000209:etiology; D014230:Triazoles / Q000627:therapeutic use*; D065819:Voriconazole
chemical_list: D000935:Antifungal Agents; D000970:Antineoplastic Agents; D011743:Pyrimidines; D014230:Triazoles; D065819:Voriconazole