Circulating and tumor-infiltrating gamma delta T Cells in patients with B-cell lymphomas.
In order to analyze the involvement of gamma delta T cells in the immune surveillance against B cell lymphomas (BCL), we investigated the proportion of circulating gamma delta T cells in 52 BCL patients using two-color flow cytometry, together with tumor-infiltrating gamma delta T cells in 22 of those patients. We found that the proportion of tumor-infiltrating gamma delta T cells in BCL patients was not different from that of lymph node gamma delta T cells in reactive hyperplasia patients. However, a decreased percentage of circulating gamma delta T cells were observed in indolent lymphoma (IL) and limited aggressive lymphoma (AL) patients when compared with normal controls. In contrast, as a result of a histogram, advanced AL patients were divided into two subgroups: the patients with increased circulating gamma delta T cells and those without any increase. However, there was no difference in the clinical features of between the two AL subgroups.
Kuriyama
Y
Y
First Department of Internal Medicine, Tokyo Medical University, 6-7-1, Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
Kawanishi
Y
Y
Otawa
M
M
Utsumi
K
K
Ohyashiki
K
K
D000328:Adult; D000367:Age Factors; D000368:Aged; D001775:Blood Circulation; D005434:Flow Cytometry; D006801:Humans; D007107:Immune System / Q000166:cytology; D008198:Lymph Nodes / Q000166:cytology; D016246:Lymphocytes, Tumor-Infiltrating / Q000166:cytology*; D016393:Lymphoma, B-Cell / Q000097:blood* / Q000175:diagnosis / Q000276:immunology; D016555:Matched-Pair Analysis; D008875:Middle Aged; D011379:Prognosis; D019310:Pseudolymphoma / Q000473:pathology; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000097:blood* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D016692:Receptors, Antigen, T-Cell, gamma-delta