Teratogenic effects of dilantin on thoraco-abdominal organs of developing chick embryos.
Congenital anomalies on some viscera like heart, liver and kidney have been investigated in chick embryos after a single injection of dilantin (3 mg/egg), a known antiepileptic drug, on 4th day of incubation. On 19th day of incubation, chick embryos were collected to observe the gross malformations and histological changes in heart, liver and kidney. On gross examination, visceroptosis (29%), thin anterior abdominal wall (28%), ectopia cordis (10%) and dextrocardia (1%) were observed. Histological examination of the kidney revealed glomerular degeneration in kidney while in liver, dilated central veins with degenerated hepatocytes were present. Longitudinal section of the heart showed thicker musculature specially of ventricles with a narrower lumen in comparison to that of the control. The results indicate teratogenicity of dilantin in developing chick embryos.
Singh
M
M
Department of Anatomy, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, India.
Shah
G L
GL
Singh
K P
KP
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002642:Chick Embryo; D006321:Heart / Q000187:drug effects* / Q000196:embryology; D006330:Heart Defects, Congenital / Q000139:chemically induced; D007668:Kidney / Q000002:abnormalities / Q000187:drug effects* / Q000196:embryology; D008099:Liver / Q000002:abnormalities / Q000187:drug effects* / Q000196:embryology; D010672:Phenytoin / Q000494:pharmacology*; D013723:Teratogens / Q000494:pharmacology*
D000927:Anticonvulsants; D013723:Teratogens; D010672:Phenytoin