[Research on fibrotic effect of Ni-Ti and 317L alloys in esophagus].
This study was conducted to examiune the fibrotic effect of Ni-Ti and 317L alloys in esophagus. The extract fluid from Ni-Ti, 317L alloys was made according to the ASTM standards of U.S.A. The Fb of esophageal scar was cultured primarily, then incubated with alloy abstract fluid. The proliferating activity of Fb was measured by MTT at 4, 24, 48, 72 hours in the course of culturing. The esophagus embedding test of Ni-Ti, 317L alloys was made according to ASTM standards of U.S.A. The tissue around the alloys was taken at weeks 2 and 12, and the pathologic changes were analysed. The results showed that Ni-Ti, 317L extract could depress the proliferating function of Fb gently, and the depressing action increased gradually with the culturing time. The result of embedding test was in accord with the ASTM standards of U.S.A. completely; the fibrotic membrane around the NiTi, 317L alloys became thinner with embedding time. These findings suggested that the scattering composition of Ni-Ti, 317L in body fluid might not activate the proliferating and secreting function of Fb, and the two alloys could not lead to fibrosis of esophagus aroun them.
Wan
X
X
Department of Gastroenterology, Changhai Hospital, Second Military Medical University, Shanghai 200433.
Li
Z
Z
Xu
G
G
Wu
R
R
Zhang
W
W
Man
X
X
D000497:Alloys / Q000633:toxicity*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004285:Dogs; D004947:Esophagus / Q000473:pathology*; D005260:Female; D005347:Fibroblasts / Q000187:drug effects* / Q000473:pathology; D005355:Fibrosis / Q000139:chemically induced*; D008297:Male; D008422:Materials Testing; D009532:Nickel / Q000633:toxicity*; D014025:Titanium / Q000633:toxicity*
D000497:Alloys; C040654:titanium nickelide; D009532:Nickel; D014025:Titanium