title: Nonopsonic phagocytosis of Pseudomonas aeruginoas: insights from an infant with leukocyte adhesion deficiency.
abstract: Children with leukocyte adhesion deficiency type I are at risk for overwhelming infection because their neutrophils lack surface beta 2 integrins (CD18/CD11) that normally interact with endothelial cell adhesion molecules and mediate migration to sites of bacterial invasion. In vitro studies of phagocytic cells from an infant with leukocyte adhesion deficiency type I demonstrated that complement receptor 3 (CD18/CD11b) mediates nonopsonic phagocytosis of some Pseudomonas aeruginosa strains and might play a control role in the control of Pseudomonas infections at sites where there are low levels of opsonins.
authors.affiliation: Department of Pediatrics, Children's and Women's Health Centre of British Columbia, BC Research Institute for Children's and Women's Health, Vancouver, Canada. ajpollard@compuserve.com
authors.forename: A J
authors.initials: AJ
authors.lastname: Pollard
authors.forename: J P
authors.initials: JP
authors.lastname: Heale
authors.forename: A
authors.initials: A
authors.lastname: Tsang
authors.forename: B
authors.initials: B
authors.lastname: Massing
authors.forename: D P
authors.initials: DP
authors.lastname: Speert
mesh_terms: D018821:CD18 Antigens; D006801:Humans; D007231:Infant, Newborn; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000150:complications* / Q000276:immunology; D016177:Macrophage-1 Antigen; D010587:Phagocytosis / Q000276:immunology*; D011552:Pseudomonas Infections / Q000150:complications* / Q000276:immunology*; D011550:Pseudomonas aeruginosa
chemical_list: D018821:CD18 Antigens; D016177:Macrophage-1 Antigen