title: [Clinical experience with large-core needle biopsies of the breast and evaluation of histopathology].
abstract: OBJECTIVE
  Interventional techniques allow a microinvasive diagnostic of breast lesions. We examined the reliability of large core needle biopsies for histologic diagnosis on breast lesions.
  
  
  METHODS
  143 ultrasound guided automated spring gun biopsies and 16 stereotactic guided vacuum-assisted device biopsies were analyzed. Indications included confirmation of malign or benign lesions and diagnosis of suspicious lesions.
  
  
  RESULTS
  In 113 biopsies (71%) an invasive breast carcinoma was diagnosed, in 5 biopsies (3%) in situ/atypical lesions were seen and 38 cases (24%) showed benign lesions. Based on the bioptic results, 108 patients underwent subsequent surgery. An identical histology was seen in 100/108 patients (93%), 5 biopsies were false negative (5%) and 3 specimens yielded necrotic/insufficient material. The immunohistochemical results of percutaneous biopsies and surgical specimens were comparable. 17 out of 113 patients (15%) with biopsy proven carcinoma were treated with neoadjuvant therapy. 32/38 patients with benign lesions were follow-up clinically.
  
  
  CONCLUSIONS
  Ultrasound- or stereotactic guided percutaneous biopsies are methods to confirm histological diagnosis. Based on the biopsy results the, number of surgical excisions can be reduced and treatment of biopsy proven carcinoma can be improved by individual presurgical planing.
authors.affiliation: Universitäts-Frauenklinik Tübingen.
authors.forename: N
authors.initials: N
authors.lastname: Fersis
authors.forename: B
authors.initials: B
authors.lastname: Smyczek-Gargya
authors.forename: U
authors.initials: U
authors.lastname: Krainick
authors.forename: G
authors.initials: G
authors.lastname: Mielke
authors.forename: M
authors.initials: M
authors.lastname: Müller-Schimpfle
authors.forename: L
authors.initials: L
authors.lastname: Kiesel
authors.forename: D
authors.initials: D
authors.lastname: Wallwiener
mesh_terms: D014408:Biomarkers, Tumor / Q000097:blood; D001707:Biopsy, Needle / Q000295:instrumentation* / Q000379:methods*; D001940:Breast / Q000473:pathology*; D001941:Breast Diseases / Q000175:diagnosis; D001943:Breast Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor