title: Pre-mRNA splicing in the new millennium.
abstract: The past year has witnessed refinements in models of spliceosome assembly pathways and in the understanding of how splicing factors of the serine/arginine-rich (SR) protein family function. The role of splicing in human genetic diseases has also received a lot of attention recently as exonic splicing enhancers become better understood.
authors.affiliation: Cold Spring Harbor Laboratory, 1 Bungtown Road, PO Box 100, Cold Spring Harbor, NY 11724-2208, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Hastings
authors.forename: A R
authors.initials: AR
authors.lastname: Krainer
mesh_terms: D000818:Animals; D001691:Biological Therapy / Q000379:methods; D014644:Genetic Variation / Q000235:genetics; D006801:Humans; D008958:Models, Molecular; D009687:Nuclear Proteins / Q000235:genetics / Q000378:metabolism*; D012322:RNA Precursors / Q000235:genetics / Q000378:metabolism*; D022821:RNA Splice Sites / Q000235:genetics / Q000502:physiology*; D012326:RNA Splicing / Q000235:genetics / Q000502:physiology*; D016601:RNA-Binding Proteins; D000068103:Serine-Arginine Splicing Factors; D017381:Spliceosomes / Q000235:genetics / Q000378:metabolism*
chemical_list: D009687:Nuclear Proteins; D012322:RNA Precursors; D022821:RNA Splice Sites; D016601:RNA-Binding Proteins; D000068103:Serine-Arginine Splicing Factors