The effect of Escherichia coli heat-stable toxin on the trans-epithelial intestinal elimination of ciprofloxacin in the rabbit.
The effect of Escherichia coli heat-stable toxin (ST) on the intestinal trans-epithelial elimination of ciprofloxacin was studied in the rabbit model. Following a systemic 27 mg/kg dose, excreted amounts of ciprofloxacin during the 2 h experiment were: 9.3 (+/- 4.8); 12.5 (+/- 5.2) and 0.3 (+/- 0.1) microg/cm(2) surface of intestinal wall in ST-challenged jejunal, ileal and caecal loops, respectively. In control loops the corresponding amounts were: 5.0 (+/- 2.8), 6.5 (+/- 3.4) and 0.3 (+/- 0.1) microg/cm(2), respectively. The trans-epithelial elimination of ciprofloxacin was significantly higher in ST-challenged small bowel loops than in controls while caecal elimination was negligible.
Musafija
A
A
The Infectious Diseases Unit, Sheba Medical Center, Tel Hashomer 52621, Tel Aviv University School of Medicine, Israel.
Shtelman
Y
Y
Ramon
J
J
Volk
M
M
Segev
S
S
Rubinstein
E
E
D000818:Animals; D000890:Anti-Infective Agents / Q000097:blood / Q000493:pharmacokinetics; D001427:Bacterial Toxins / Q000633:toxicity*; D002939:Ciprofloxacin / Q000097:blood / Q000493:pharmacokinetics*; D004768:Enterotoxins / Q000633:toxicity*; D029968:Escherichia coli Proteins; D008658:Inactivation, Metabolic / Q000502:physiology*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism; D007422:Intestines / Q000187:drug effects*; D023421:Models, Animal; D011817:Rabbits
D000890:Anti-Infective Agents; D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; C034151:heat stable toxin (E coli); D002939:Ciprofloxacin