title: Comparison of discharge rates and drug costs for patients with schizophrenia treated with risperidone or olanzapine.
abstract: This study compared the discharge rates and drug costs of 789 patients with schizophrenia or schizoaffective disorder who began pharmacotherapy with olanzapine or risperidone between July 1997 and June 1998. Discharge rates 30 days after the start of treatment were 45 percent for the patients treated with risperidone and 32 percent for those treated with olanzapine (p=.001). Daily drug costs during the same period were $6.42 for risperidone and $12.29 for olanzapine (p<.001). For risperidone, lower dosages were associated with higher hospital discharge rates, whereas no significant association was observed for olanzapine. These data suggest that among inpatients with schizophrenia or schizoaffective disorder, use of risperidone results in a higher discharge rate and a lower drug cost than use of olanzapine.
authors.affiliation: Maryland Psychiatric Research Center, University of Maryland School of Medicine, Baltimore, MD 21228, USA. dkelly@mprc.umaryland.edu
authors.forename: D L
authors.initials: DL
authors.lastname: Kelly
authors.forename: M W
authors.initials: MW
authors.lastname: Nelson
authors.forename: R C
authors.initials: RC
authors.lastname: Love
authors.forename: Y
authors.initials: Y
authors.lastname: Yu
authors.forename: R R
authors.initials: RR
authors.lastname: Conley
mesh_terms: D014150:Antipsychotic Agents / Q000191:economics* / Q000627:therapeutic use*; D001569:Benzodiazepines; D017281:Cost of Illness; D016527:Drug Costs / Q000706:statistics & numerical data*; D006778:Hospitals, Psychiatric / Q000191:economics* / Q000706:statistics & numerical data*; D006783:Hospitals, State / Q000191:economics / Q000706:statistics & numerical data; D006801:Humans; D008396:Maryland; D000077152:Olanzapine; D010351:Patient Discharge / Q000706:statistics & numerical data*; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000191:economics* / Q000627:therapeutic use*; D011446:Prospective Studies; D018967:Risperidone / Q000191:economics* / Q000627:therapeutic use*; D012559:Schizophrenia / Q000188:drug therapy* / Q000191:economics*; D013997:Time Factors
chemical_list: D014150:Antipsychotic Agents; D001569:Benzodiazepines; D010890:Pirenzepine; D018967:Risperidone; D000077152:Olanzapine