title: Additional bioactive Lyso-PAF congeners from the sponge Spirastrella abata.
abstract: A known (1) and four new (2--5) lyso-PAF (platelet activating factor) derivatives were isolated from the sponge Spirastrella abata. Two of them are unprecedented in having a methoxy group at C-2'. The structures have been determined by combined spectroscopic methods. Their inhibitory effect on the biosynthesis of cholesterol and cytotoxicity against human solid tumor cell lines are reported.
authors.affiliation: College of Pharmacy, Pusan National University, Pusan 609-735, Korea.
authors.forename: N
authors.initials: N
authors.lastname: Alam
authors.forename: B H
authors.initials: BH
authors.lastname: Bae
authors.forename: J
authors.initials: J
authors.lastname: Hong
authors.forename: C O
authors.initials: CO
authors.lastname: Lee
authors.forename: B A
authors.initials: BA
authors.lastname: Shin
authors.forename: K S
authors.initials: KS
authors.lastname: Im
authors.forename: J H
authors.initials: JH
authors.lastname: Jung
mesh_terms: D000818:Animals; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera
chemical_list: C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor