title: [New cases of leprosy at the Marchoux Institute: a comparative study 1988-1997].
abstract: BACKGROUND
  The prevalence of leprosy had declined greatly over the last decade. The purpose of this work was to determine whether changes in the epidemiology, clinical and bacteriological patterns occurred among patients with leprosy treated at the Marchoux Institute in 1988 and in 1997.
  
  
  METHODS
  We conducted a descriptive cross-sectional study, reviewing retrospectively all files of patients with leprosy seen in 1988 in comparison with a prospective series of leprosy patients seen in 1997. Only new cases of leprosy, prior to treatment and with skin and/or nervous lesions irrespective of the bacilloscopy results, were included in the two series.
  
  
  RESULTS
  We included 93 patients among 246 patient files in 1988. There were 119 new cases in 1997. The following variables showed changes: mean delay to consultation (41.2 months in 1988 versus 26.1 months in 1997; patient's suspicion of having leprosy (93 patients in 1988 versus 22 in 1997); notion of contact (35 cases in 1988 versus 45 in 1997). Multibacilli leprosy predominated over paucibacilli leprosy in 1988 (51 versus 42 cases). This trend was inverted in 1997 (44 versus 75) (p<0.009). Patients with grade 2 handicap were more numerous in 1988 (20 cases versus 2 cases, p<0.001).
  
  
  CONCLUSIONS
  These findings demonstrate a change in the epidemiology, clinical and bacilloscopic pattern of patients with leprosy from 1988 to 1997.
authors.affiliation: Observatoire de la Lèpre en Afrique (OLA), BP 2759, Bamako, Mali.
authors.forename: S
authors.initials: S
authors.lastname: Keita
authors.forename: A
authors.initials: A
authors.lastname: Tiendrebeogo
authors.forename: H
authors.initials: H
authors.lastname: Konare
authors.forename: B S
authors.initials: BS
authors.lastname: Cisse
authors.forename: O
authors.initials: O
authors.lastname: Faye
mesh_terms: D000328:Adult; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D007918:Leprosy / Q000453:epidemiology*; D008297:Male; D008302:Mali; D011446:Prospective Studies; D012189:Retrospective Studies