Transient pseudohypoparathyroidism and neonatal seizure.
The case of a neonate is presented who had late onset seizure associated with hypocalcemia, hyperphosphatemia, and raised parathyroid hormone. The infant did not have any stigmata of pseudohypoparathyroidism. The hypocalcemia was initially resistant to calcium therapy, but responded to vitamin D analog therapy. The diagnosis of 'transient neonatal pseudohypoparathyroidism' was entertained, as the infant remained stable and seizure-free with normal serum biochemistry during 8 months of follow-up.
Manzar
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Department of Child Health, Sultan Qaboos University Hospital, Al-Khoud, Muscat, Sultanate of Oman. shabiman@hotmail.com
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D006996:Hypocalcemia / Q000150:complications* / Q000188:drug therapy; D007231:Infant, Newborn; D011547:Pseudohypoparathyroidism / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D012640:Seizures / Q000209:etiology*; D016896:Treatment Outcome
D000276:Adjuvants, Immunologic; D006887:Hydroxycholecalciferols; C008088:alfacalcidol