Kynurenic acid does not protect against nicotine-induced seizures in mice.
Kynurenic acid, an antagonist of glutamatergic ionotropic receptors and alpha7 nicotinic cholinergic receptors failed to affect nicotine-induced convulsions in mice which may indicate that alpha7 nicotinic receptor-mediated events play no role in seizure activity produced by nicotine.
Kiś
J
J
Department of Pharmacology and Toxicology, Medical University, Lublin, Poland.
Czuczwar
M
M
Zielińska
E
E
Bojar
I
I
Czuczwar
S J
SJ
Turski
W A
WA
D000818:Animals; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D007736:Kynurenic Acid / Q000494:pharmacology*; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D051379:Mice; D009538:Nicotine; D018722:Nicotinic Agonists; D018733:Nicotinic Antagonists / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D018691:Excitatory Amino Acid Antagonists; D018722:Nicotinic Agonists; D018733:Nicotinic Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D008464:Mecamylamine; D016291:Dizocilpine Maleate; D009538:Nicotine; D007736:Kynurenic Acid