title: Time resolved optical tomography of the human forearm.
abstract: A 32-channel time-resolved optical imaging instrument has been developed principally to study functional parameters of the new-born infant brain. As a prelude to studies on infants, the device and image reconstruction methodology have been evaluated on the adult human forearm. Cross-sectional images were generated using time-resolved measurements of transmitted light at two wavelengths. All data were acquired using a fully automated computer-controlled protocol. Images representing the internal scattering and absorbing properties of the arm are presented, as well as images that reveal physiological changes during a simple finger flexion exercise. The results presented in this paper represent the first simultaneous tomographic reconstruction of the internal scattering and absorbing properties of a clinical subject using purely temporal data, with additional co-registered difference images showing repeatable absorption changes at two wavelengths in response to exercise.
authors.affiliation: Department of Medical Physics and Bioengineering, University College London, UK.
authors.forename: E M
authors.initials: EM
authors.lastname: Hillman
authors.forename: J C
authors.initials: JC
authors.lastname: Hebden
authors.forename: M
authors.initials: M
authors.lastname: Schweiger
authors.forename: H
authors.initials: H
authors.lastname: Dehghani
authors.forename: F E
authors.initials: FE
authors.lastname: Schmidt
authors.forename: D T
authors.initials: DT
authors.lastname: Delpy
authors.forename: S R
authors.initials: SR
authors.lastname: Arridge
mesh_terms: D000328:Adult; D001132:Arm / Q000000981:diagnostic imaging*; D002138:Calibration; D015444:Exercise; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008953:Models, Anatomic; D012542:Scattering, Radiation; D012984:Software; D013997:Time Factors; D014057:Tomography, X-Ray Computed / Q000379:methods*