Characterization of the solid-state: spectroscopic techniques.
The physical characterization of pharmaceutical solids is an integral aspect of the drug development process. This review summarizes the use of solid-state spectroscopy techniques used in the physical characterization of the active pharmaceutical ingredient, excipients, physical mixtures, and the final dosage form. A brief introduction to infrared, Raman, and solid-state NMR experimental techniques are described as well as a more thorough description of qualitative and quantitative applications. The use of solid-state imaging techniques such as IR, Raman, and TOF-SIMS is also introduced to the reader.
Bugay
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SSCI Inc., 3065 Kent Avenue, West Lafayette, IN 47906, USA. debugay@ssci-inc.com
D002626:Chemistry, Pharmaceutical; D009682:Magnetic Resonance Spectroscopy; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D019265:Spectroscopy, Near-Infrared; D013059:Spectrum Analysis, Raman
D004364:Pharmaceutical Preparations