Microxine, a new cdc2 kinase inhibitor from the Australian marine sponge Microxina species.
A new purine derivative microxine (1) was isolated from the Australian marine sponge Microxina sp. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. Microxine was found to weakly inhibit cdc2 kinase activity with an IC(50) of 13 microM.
Killday
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KB
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, Florida 34946, USA.
Yarwood
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Sills
M A
MA
Murphy
P T
PT
Hooper
J N
JN
Wright
A E
AE
D000818:Animals; D016203:CDC2 Protein Kinase / Q000037:antagonists & inhibitors*; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015394:Molecular Structure; D011161:Porifera / Q000737:chemistry*; D011687:Purines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013057:Spectrum Analysis
D004791:Enzyme Inhibitors; D011687:Purines; C430185:microxine; D016203:CDC2 Protein Kinase