Genetic polymorphisms of thiopurine S-methyltransferase and 6-mercaptopurine toxicity in Japanese children with acute lymphoblastic leukaemia.
Ando
M
M
First Department of Internal Medicine, Nagoya University School of Medicine, 65 Tsurumai-cho, Showaku, Nagoya 466-8550, Japan.
Ando
Y
Y
Hasegawa
Y
Y
Sekido
Y
Y
Shimokata
K
K
Horibe
K
K
D000293:Adolescent; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006579:Heterozygote; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D015122:Mercaptopurine / Q000009:adverse effects*; D008780:Methyltransferases / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000201:enzymology* / Q000208:ethnology
D000964:Antimetabolites, Antineoplastic; D015122:Mercaptopurine; D008780:Methyltransferases; C022745:thiopurine methyltransferase