[The study of platelet function in patients with chronic pulmonary heart disease].
OBJECTIVE
To study the platelet function in patients with chronic pulmonary heart disease.


METHODS
Subjects were divided into three groups (cor pulmonale exacerbation, cor pulmonale remission stage and normal control). Platelet adhesion rate (PAdT), platelet aggregation rate(PAgT), alpha-granule membrane protein (GMP-140) and glycoproteinII were measured by radioimmunoassay, flow cytometry and other methods.


RESULTS
In cor pulmonale exacerbation, the values of PAdT, PAgT, GMP-140 and GPII were31% +/- 16%, 14% +/- 8%, 190 +/- 49 molecule/platelet and 145% +/- 36% respectively. In cor pulmonale remission stage, the values were 33% +/- 13%, 38% +/- 16%, 178 +/- 33 molecule/platelet and 137% +/- 48% respectively. These findings showed that the values of PAdT, GMP-140 and GPII in cor pulmonale exacerbation were markedly increased, whereas PAgT was significantly reduced. However, PAdT, PAgT, GMP-140 and GPII in remission stage were all higher than that of normal group.


CONCLUSIONS
In vivo platelet activation is indeed present in patients with chronic pulmonary heart disease.
Gao
Y
Y
Department of Respiratory Disease, Beijing Anzhen Hospital, Capital University of Medical Sciences, Beijing 100029.
Weng
X
X
Chen
S
S
D000368:Aged; D001792:Blood Platelets / Q000378:metabolism / Q000502:physiology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D039421:Integrin alpha2; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011660:Pulmonary Heart Disease / Q000097:blood*
C056564:ITGA2B protein, human; D039421:Integrin alpha2; D008562:Membrane Glycoproteins; D019007:P-Selectin