title: [Effect of estriol treatment per vaginam before Burch culposuspension].
abstract: BACKGROUND
  To assess the effect of estriol treatment per vaginam before Burch culposuspension in postmenopausal women with stress urinary incontinence (IUS).
  
  
  METHODS
  
  
  
  METHODS
  prospective randomised study.
  
  
  METHODS
  Department of Gynaecology, Obstetrics and Physiopathology of Human Reproduction-Medical School-University of Naples  Federico II .
  
  
  METHODS
  twenty women in postmenopause at least from five years with a urogenital symptomatology due to IUS.
  
  
  METHODS
  women were randomised into one of two groups (treated or control) and they were submitted to an evaluation of vulva and vagina trophism. All the women were submitted to a urodynamic examination and to a transvaginal ultrasonography with evaluation of pubis-bladder neck distance, bladder and proximal urethra position, before treatment, one week before the operation and after six months from the same operation.
  
  
  METHODS
  subjective symptomatology and urodynamic parameters between treated and control groups before and after operation.
  
  
  RESULTS
  After 12 weeks of treatment, a significant improvement of subjective symptomatology and a not significant improvement of all the urodynamic parameters in the treated group in comparison with the control group have been demonstrated, while any anatomic alteration compared with the basal hasn t been observed. After six months from the operation in all the women a significant reduction of subjective quantity of urine lost after a strain has been demonstrated and significant variations of urodynamic parameters without significant differences between treated group and control group were also observed.
  
  
  CONCLUSIONS
  The estriol treatment per vaginam is not so effective on the result of Burch culposuspension in postmenopausal women with IUS.
authors.affiliation: Istituto di Ginecologia, Ostetricia e Fisiopatologia della Riproduzione Umana, Facoltà di Medicina e Chirurgia, Università degli Studi Federico II, Naples, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Palomba
authors.forename: V
authors.initials: V
authors.lastname: Napolitano
authors.forename: A
authors.initials: A
authors.lastname: Sammartino
authors.forename: A
authors.initials: A
authors.lastname: Di Spiezio Sardo
authors.forename: M
authors.initials: M
authors.lastname: Vassallo
authors.forename: V
authors.initials: V
authors.lastname: Mandato
authors.forename: M
authors.initials: M
authors.lastname: Ruoto
authors.forename: G
authors.initials: G
authors.lastname: Acunzo
authors.forename: C
authors.initials: C
authors.lastname: Votino
authors.forename: C
authors.initials: C
authors.lastname: Nappi
mesh_terms: D000282:Administration, Intravaginal; D004964:Estriol / Q000008:administration & dosage*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause; D011446:Prospective Studies; D013997:Time Factors; D014463:Ultrasonography; D014550:Urinary Incontinence, Stress / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000601:surgery*; D014563:Urodynamics; D014621:Vagina / Q000601:surgery*
chemical_list: D004964:Estriol