title: Osteoporosis prevention in myasthenia gravis: a reminder.
abstract: OBJECTIVE
  Consensus guidelines for bone management of patients taking corticosteroids suggest two main interventions: Dual energy X-ray absorptiometry (DEXA) scanning in those taking prednisolone > or =7.5 mg daily for > or =6 months (repeated every 1-3 years as indicated). Bisphosphonate therapy for those taking prednisolone > or =15 mg daily for > or =6 months regardless of DEXA result, and also for patients with known or high risk of developing osteoporosis (including those aged >65 years).
  
  
  METHODS
  We audited adherence to these guidelines in all adults with myasthenia gravis (MG) attending our neurology service.
  
  
  RESULTS
  Of 80 patients with MG (47 male, mean age 63.3 years), 34 (43%) had received corticosteroids for > or =6 months. Eighteen were taking prednisolone > or =7.5 mg daily (mean dose 16.6 mg) yet only 4 of these (22%) had undergone DEXA scanning. Of the 13 patients meeting the guideline criteria to receive bisphosphonate therapy, this was prescribed to only 7 (54%). Two others were prescribed vitamin D, 2 a calcium supplement and 2 were receiving no prophylaxis.
  
  
  CONCLUSIONS
  In these MG patients the guidelines were followed in only a minority. Neurologists need greater awareness of the bone health consequences of prescribing long-term corticosteroids.
authors.affiliation: Department of Neurology, University Hospital of Wales, Cardiff, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Lewis
authors.forename: P E
authors.initials: PE
authors.lastname: Smith
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects*; D000368:Aged; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D019983:Guideline Adherence; D006801:Humans; D008297:Male; D008485:Medical Audit; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications*; D010024:Osteoporosis / Q000209:etiology / Q000517:prevention & control*; D017410:Practice Guidelines as Topic; D014807:Vitamin D / Q000627:therapeutic use
chemical_list: D000305:Adrenal Cortex Hormones; D004164:Diphosphonates; D014807:Vitamin D