Intravesical oncolytic viral therapy using attenuated, replication-competent herpes simplex viruses G207 and Nv1020 is effective in the treatment of bladder cancer in an orthotopic syngeneic model.
Cozzi
P J
PJ
The George M O'Brien Urology Research Center, Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021, USA.
Malhotra
S
S
McAuliffe
P
P
Kooby
D A
DA
Federoff
H J
HJ
Huryk
B
B
Johnson
P
P
Scardino
P T
PT
Heston
W D
WD
Fong
Y
Y
D000818:Animals; D001691:Biological Therapy / Q000379:methods*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D018139:Simplexvirus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology*; D014407:Tumor Cells, Cultured; D001749:Urinary Bladder Neoplasms / Q000628:therapy* / Q000821:virology*; D014779:Virus Replication