title: Physical stabilization of DNA-based therapeutics.
abstract: The development of non-viral vectors for gene delivery has primarily focused on improving the efficiency of gene transfer in vivo. Although there is clearly a need to improve delivery efficiency, studies also indicate that the physical stability of non-viral vectors is not nearly adequate for a marketable pharmaceutical product. Here, we describe the different strategies that have been used to enhance stability and discuss the mechanisms by which prolonged stabilization (>2 years) might be achieved.
authors.affiliation: School of Pharmacy, University of Colorado, 80262, Denver, CO, USA
authors.forename: T J.
authors.initials: TJ
authors.lastname: Anchordoquy
authors.forename: S D.
authors.initials: SD
authors.lastname: Allison
authors.forename: M d.C.
authors.initials: MC
authors.lastname: Molina
authors.forename: L G.
authors.initials: LG
authors.lastname: Girouard
authors.forename: T K.
authors.initials: TK
authors.lastname: Carson