Breast-feeding by a cyclosporine-treated mother.
BACKGROUND
Cyclosporine is known to be excreted in breast milk, but levels in infants are not known. Post-transplant breast-feeding has been contraindicated in mothers treated with calcineurin inhibitors such as cyclosporine.


METHODS
A 35-year-old woman exclusively breast-fed her infant during the first 10.5 months of life while she was being treated with cyclosporine. Cyclosporine measurements in infant and maternal blood and breast milk revealed a mean breast milk/maternal blood level ratio of 84%, but undetectable levels in the infant. The infant grew and developed normally.


CONCLUSIONS
The infant of a cyclosporine-treated mother was breast-fed exclusively during the first 10.5 months of life and did not absorb a detectable amount of the drug. Fetal growth and development were normal.
Munoz-Flores-Thiagarajan
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Department of Biobehavioral Nursing and Health Systems, School of Nursing, University of Washington, Box 357266, Seattle, WA 98195, USA. binga@u.washington.edu
Easterling
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Davis
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Bond
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EF
D000328:Adult; D001942:Breast Feeding; D016572:Cyclosporine / Q000378:metabolism* / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism* / Q000627:therapeutic use; D007231:Infant, Newborn; D007676:Kidney Failure, Chronic; D016030:Kidney Transplantation; D008297:Male; D008895:Milk, Human / Q000378:metabolism*; D016035:Pancreas Transplantation; D049590:Postpartum Period; D011247:Pregnancy; D011248:Pregnancy Complications / Q000628:therapy*
D007166:Immunosuppressive Agents; D016572:Cyclosporine