Effects of coffee cherry, the residue left after removal of the beans from the coffee fruit, on mammary glands, automatic behavior and related parameters in mice.
To clarify the mechanisms of the anti-mammary tumor activity of coffee cherry (CC), the residue left after the removal of beans from the fruit, the effects in SHN mice of CC on plasma and urine component levels, mammary gland growth, spontaneous motor activity and several related parameters were examined. Hot water extract of CC was given to 2-month-old mice in drinking water (0.5%) for 60 days. The treatment prevented the elevation of plasma and urine levels of alanin amino-transferase and asparate aminotransferase, indicating that CC can protect against metabolic abnormality, which is a cause of the high mammary tumor susceptibility of SHN mice. It also resulted in an inhibition of the formation of precancerous mammary hyperplastic alveolar nodules. Neither food and water intake nor spontaneous motor activity was affected by CC. The findings provide novel information on the mechanism of the protective effect of CC on mammary tumorigenesis and confirm the usefulness of CC as a safe chemopreventive agent of mammary and other types of tumors.
Nagasawa
H
H
Experimental Animal Research Laboratory, Meiji University, Kawasaki, Japan.
Yada
E
E
Udagawa
Y
Y
Inatomi
H
H
D000410:Alanine Transaminase / Q000097:blood / Q000652:urine; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood / Q000652:urine; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003069:Coffee; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D005638:Fruit; D008321:Mammary Glands, Animal / Q000187:drug effects*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D011230:Precancerous Conditions
D003069:Coffee; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase