title: Liver support systems.
abstract: In recent years liver transplantation was shown to be the only clinically effective method of treating acute or chronic hepatic failure due to various causes. However, this ultimate therapeutic approach is limited by the growing disparity between organ donation and the number of patients on the waiting list. Factors such as high cost, morbidity, and the need for lifelong immunosuppression accelerated the research on alternative methods to support the failing liver. Recently, new technologies incorporating hepatocytes and extracorporeal circulation devices were introduced for liver support. This review presents current knowledge on liver support systems and their role in the treatment of acute liver failure.
authors.affiliation: General Intensive Care Unit, Tel Aviv Sourasky Medical Center and Sackler Faculty of Medicine, Tel Aviv University, Israel.
authors.forename: P
authors.initials: P
authors.lastname: Sorkine
authors.forename: R
authors.initials: R
authors.lastname: Ben Abraham
authors.forename: S
authors.initials: S
authors.lastname: Brill
authors.forename: O
authors.initials: O
authors.lastname: Szold
mesh_terms: D000328:Adult; D019149:Bioreactors; D002648:Child; D006801:Humans; D008021:Life Support Systems; D017114:Liver Failure, Acute / Q000209:etiology / Q000628:therapy; D016031:Liver Transplantation; D019164:Liver, Artificial