Primary effusion lymphoma in an HIV-negative patient with no serologic evidence of Kaposi's sarcoma virus.
Primary effusion lymphoma (PEL) is a newly described high-grade B cell lymphoma which develops in association with Kaposi's sarcoma-associated herpesvirus (KSV) in human immunodeficiency virus (HIV)-infected individuals. We hereby describe a very unusual presentation of PEL that developed in the abdominal cavity of an HIV negative, KSV negative patient with a 1-year history of refractory ascites due to alcohol-related liver cirrhosis. Possible factors aiding lymphomagenesis in the cirrhotic state are discussed.
Rodriguez
J
J
Departments of Lymphoma/Myeloma and Pathology, The University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
Romaguera
J E
JE
Katz
R L
RL
Said
J
J
Cabanillas
F
F
D000008:Abdominal Neoplasms / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D000368:Aged; D000956:Antigens, Viral / Q000097:blood; D003937:Diagnosis, Differential; D018023:HIV Seronegativity; D006801:Humans; D016130:Immunophenotyping; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications*; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D016393:Lymphoma, B-Cell / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D008297:Male; D012514:Sarcoma, Kaposi / Q000150:complications*
D000956:Antigens, Viral