title: Translocation t(1;3)(p36.3;q25) is a nonrandom aberration in epithelioid hemangioendothelioma.
abstract: The cytogenetic findings for two epithelioid hemangioendotheliomas are reported. An identical chromosomal translocation involving chromosomes 1 and 3 [t(1;3)(p36.3;q25)] was detected in both cases of epithelioid hemangioendothelioma, possibly representing a characteristic rearrangement for this histopathologic entity. The presence of clonal karyotypic abnormalities supports a neoplastic origin for the epithelioid variant of hemangioendothelioma. Identification of the 1;3 translocation may be useful diagnostically. Should additional studies confirm these data, this could lead to the identification of the gene(s) central to this neoplastic process.
authors.affiliation: Departments of Pathology & Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68198-3135, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Mendlick
authors.forename: M
authors.initials: M
authors.lastname: Nelson
authors.forename: D
authors.initials: D
authors.lastname: Pickering
authors.forename: S L
authors.initials: SL
authors.lastname: Johansson
authors.forename: T A
authors.initials: TA
authors.lastname: Seemayer
authors.forename: J R
authors.initials: JR
authors.lastname: Neff
authors.forename: G
authors.initials: G
authors.lastname: Vergara
authors.forename: H
authors.initials: H
authors.lastname: Rosenthal
authors.forename: J A
authors.initials: JA
authors.lastname: Bridge
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D002878:Chromosomes, Human, Pair 1; D002893:Chromosomes, Human, Pair 3; D002999:Clone Cells; D005260:Female; D018323:Hemangioendothelioma, Epithelioid / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008113:Liver Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D019408:Platelet Endothelial Cell Adhesion Molecule-1 / Q000032:analysis; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology; D014178:Translocation, Genetic
chemical_list: D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1