Cutting edge: a NK complex-linked locus governs acute versus latent herpes simplex virus infection of neurons.
Herpes simplex causes latent infections that periodically reactivate. Specific immunization attempts are failing to control herpes, prompting a fresh look at which host responses predominate. We report a NK complex-linked genetic locus, Rhs1, whose alleles influence the magnitude of experimental herpes simplex. Rhs1 provided rapid control of primary infection but caused a reciprocal increase in the number of latently infected neurons. Thus, in principle, establishment of latency is a consequence of efficient front line defense against herpesvirus infection. Based on conservation between human and mouse NK complexes, the data predict the presence of a human Rhs1 orthologue on chromosome 12p12-13.
Pereira
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RA
Pediatric Virology and Sealy Center for Vaccine Development, University of Texas Medical Branch, Galveston, TX 77555, USA.
Scalzo
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Simmons
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D000208:Acute Disease; D000818:Animals; D000941:Antigens / Q000502:physiology; D000954:Antigens, Surface; D002874:Chromosome Mapping; D005260:Female; D017950:Ganglia, Sensory / Q000276:immunology / Q000821:virology; D005819:Genetic Markers / Q000276:immunology; D006561:Herpes Simplex / Q000235:genetics / Q000276:immunology* / Q000401:mortality / Q000821:virology; D007113:Immunity, Innate / Q000235:genetics; D007694:Killer Cells, Natural / Q000276:immunology* / Q000821:virology*; D037181:Lectins, C-Type; D007928:Lethal Dose 50; D051379:Mice; D020297:Mice, Congenic; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D055651:NK Cell Lectin-Like Receptor Subfamily B; D009474:Neurons / Q000276:immunology* / Q000821:virology*; D010525:Peripheral Nerves / Q000276:immunology / Q000821:virology; D010641:Phenotype; D011506:Proteins / Q000502:physiology; D012867:Skin / Q000276:immunology / Q000473:pathology / Q000821:virology; D013045:Species Specificity; D019562:Viral Load; D017735:Virus Latency / Q000235:genetics / Q000276:immunology*
D000941:Antigens; D000954:Antigens, Surface; D005819:Genetic Markers; C527203:KLRB1 protein, human; D037181:Lectins, C-Type; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011506:Proteins