title: Expression of the Thomsen-Friedenreich (TF) antigen in the human placenta.
abstract: The Thomsen-Friedenreich (TF) antigen (or, more precisely, epitope; Gal beta 1-3GalNAc-) has been known for a long time as a pancarcinoma antigen. Here we report the immunohistochemical identification of this carbohydrate antigen in the human placenta. Paraffin-embedded placental and decidual tissues of the first, second and third trimester were incubated with different monoclonal antibodies (A78-G/A7 and HH8) directed against the TF-epitope and stained with an immunohistochemistry system. We found a strong expression of the TF-epitope in the first trimester of pregnancy. In addition, we identified an expression of the TF-antigen in the second trimester of pregnancy but only in a few cases a positive staining in the third trimester of pregnancy.
authors.affiliation: University of Rostock, Department of Obstetrics and Gynaecology, Doberaner Str. 142, D-18055 Rostock, Germany.
authors.forename: D U
authors.initials: DU
authors.lastname: Richter
authors.forename: U
authors.initials: U
authors.lastname: Jeschke
authors.forename: J
authors.initials: J
authors.lastname: Makovitzky
authors.forename: S
authors.initials: S
authors.lastname: Goletz
authors.forename: U
authors.initials: U
authors.lastname: Karsten
authors.forename: V
authors.initials: V
authors.lastname: Briese
authors.forename: K
authors.initials: K
authors.lastname: Friese
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000096:biosynthesis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000166:cytology / Q000378:metabolism*
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; C016467:Thomsen-Friedenreich antigen