title: Sensitization to silk and childhood asthma in rural China.
abstract: OBJECTIVE
  Sensitization to perennial aeroallergens is associated with asthma in industrialized countries with a Western lifestyle. Because silk products are commonly used in Chinese society, we were interested in examining the relation between sensitization to silk and asthma.
  
  
  METHODS
  Cross-sectional study of 871 children in 503 families living in Anqing, a predominantly rural province of China.
  
  
  RESULTS
  After adjustment for age, gender, familial correlations, and sensitization to other aeroallergens, skin test reactivity to silk was an independent predictor of asthma (odds ratio = 2.6; 95% confidence interval = 1.2-5.7). This association became stronger after inclusion of the eosinophil count and history of parasitic diseases of the participants in the multivariate model (odds ratio = 3.6; 95% confidence interval = 1.4-8.9).
  
  
  CONCLUSIONS
  Because sericulture is an important activity in China and other countries throughout the world, sensitization to silk may influence the pathogenesis and severity of asthma in people living in these nations.
authors.affiliation: Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA. juan.celedon@channing.harvard.edu
authors.forename: J C
authors.initials: JC
authors.lastname: Celedón
authors.forename: L J
authors.initials: LJ
authors.lastname: Palmer
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Fang
authors.forename: S T
authors.initials: ST
authors.lastname: Weiss
mesh_terms: D000485:Allergens / Q000276:immunology*; D001249:Asthma / Q000453:epidemiology*; D002648:Child; D002681:China / Q000453:epidemiology; D003430:Cross-Sectional Studies; D004804:Eosinophils; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000453:epidemiology*; D019476:Insect Proteins / Q000276:immunology*; D007958:Leukocyte Count; D008297:Male; D010272:Parasitic Diseases / Q000453:epidemiology; D012424:Rural Population; D047011:Silk; D012882:Skin Tests
chemical_list: D000485:Allergens; D019476:Insect Proteins; D047011:Silk