Metabolic genetic polymorphisms and susceptibility to lung cancer.
Activity of some enzymes implicated in the metabolism of tobacco carcinogens presents a great variability between individuals due to the existence of a polymorphism in gene coding for these enzymes. Individual susceptibility to develop lung cancer could therefore depend not only on exposure to tobacco smoking, but also on genetic capacity to activate or inactivate tobacco carcinogens. This article summarizes the state of knowledge on metabolic polymorphisms and lung cancer susceptibility, and opens the discussion on the future direction of this promising way of research.
Bouchardy
C
C
Geneva Cancer Registry, Boulevard de la Cluse 55, 1205 Geneva, Switzerland. christine.bouchardymagnin@imsp.unige.ch
Benhamou
S
S
Jourenkova
N
N
Dayer
P
P
Hirvonen
A
A
D001191:Arylamine N-Acetyltransferase / Q000235:genetics / Q000378:metabolism; D001711:Biotransformation / Q000235:genetics; D002273:Carcinogens / Q000493:pharmacokinetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics* / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D006571:Heterocyclic Compounds / Q000493:pharmacokinetics; D006801:Humans; D008658:Inactivation, Metabolic / Q000235:genetics; D007527:Isoenzymes / Q000235:genetics* / Q000378:metabolism; D008175:Lung Neoplasms / Q000201:enzymology / Q000209:etiology / Q000235:genetics*; D008861:Microsomes / Q000201:enzymology; D011084:Polycyclic Aromatic Hydrocarbons / Q000493:pharmacokinetics; D011110:Polymorphism, Genetic; D012907:Smoking / Q000009:adverse effects
D002273:Carcinogens; D006571:Heterocyclic Compounds; D007527:Isoenzymes; D011084:Polycyclic Aromatic Hydrocarbons; D003577:Cytochrome P-450 Enzyme System; D001191:Arylamine N-Acetyltransferase; D005982:Glutathione Transferase