title: Intracystic pressure and viability in hydatid disease of the liver.
abstract: BACKGROUND
  Knowledge on the viability of hydatid cysts of the liver during operation is important to the surgeon may dictate the peri-operative therapeutic manoeuvre undertaken.
  
  
  METHODS
  A prospective study was performed on 23 patients with 28 hydatid cysts of the liver to assess whether intracystic pressure (ICP) could predict viability of protoscoleces. All patients received albendazole (10 mg/kg body weight/day) for 5 days pre-operatively. The ICP was measured from the apex of the cyst, after laparotomy, using a 16-G needle connected to a water manometer. After manometry, the cyst contents were aspirated and the viability of protoscoleces assessed by their flame cell activity, motility and ability to exclude 5% aqueous eosin.
  
  
  RESULTS
  The median ICP was 54 +/- 21 cmH2O for 17 viable cysts and zero for 8 non-viable cysts, while 1 additional non-viable cyst and 2 sterilized cysts had high ICP (sensitivity, 100%; specificity, 72%; accuracy, 89%). The median diameter of the viable cysts was 9.3 +/- 3.5 cm and the non-viable cysts 10.7 +/- 2.6 cm. In the right lobe were located 12 viable and 8 non-viable cysts and in the left lobe, 5 viable and 3 non-viable cysts. No significant difference in diameter or ICP were noted between the hepatic lobes.
  
  
  CONCLUSIONS
  These findings suggest that the measurement of ICP is a simple, cheap and reliable method for assessment of the viability of hydatid cysts of the liver.
authors.affiliation: Department of Surgery, G. Hatzikosta General Hospital, Ioannina, Greece.
authors.forename: E C
authors.initials: EC
authors.lastname: Tsimoyiannis
authors.forename: P
authors.initials: P
authors.lastname: Siakas
authors.forename: G
authors.initials: G
authors.lastname: Glantzounis
authors.forename: J C
authors.initials: JC
authors.lastname: Tsimoyiannis
authors.forename: M
authors.initials: M
authors.lastname: Karayianni
authors.forename: K J
authors.initials: KJ
authors.lastname: Gossios
mesh_terms: D000328:Adult; D000368:Aged; D004444:Echinococcosis, Hepatic / Q000175:diagnosis / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011312:Pressure; D011446:Prospective Studies