title: Lack of hematologic effects of recent ethanol ingestion by trauma patients.
abstract: A retrospective investigation was conducted to determine if acute ethanol (EtOH) ingestion before injury leads to hematologic impairment as noted by coagulation and transfusion parameters. Patients older than 18 years of age were grouped according to the presence or absence of detectable EtOH concentrations in the blood, with further subdivision based on an Injury Severity Score of 8 or less or 9 or more. The following direct and indirect indicators of hematologic function were studied: volume of resuscitation fluids administered (including blood products), prothrombin time, partial thromboplastin time, and hematocrit. Of the 304 patients who were evaluated, 152 had detectable EtOH concentrations and 136 had undetectable EtOH concentrations; 16 patients had not been tested for blood EtOH concentrations and were excluded from the analysis. There were no significant differences between groups with regard to blood or fluid requirements or coagulation parameters. Detectable blood EtOH concentrations in trauma patients are not associated with significant changes in transfusion requirements or coagulation parameters compared to patients without detectable EtOH concentrations.
authors.affiliation: Department of Pharmacy Practice and Science, University of Arizona, Tucson, Arizona, USA.
authors.forename: B L
authors.initials: BL
authors.lastname: Erstad
authors.forename: C M
authors.initials: CM
authors.lastname: Costa
authors.forename: J A
authors.initials: JA
authors.lastname: Daller
authors.forename: J B
authors.initials: JB
authors.lastname: Fortune
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000435:Alcoholic Intoxication / Q000097:blood* / Q000628:therapy*; D001769:Blood / Q000187:drug effects; D000431:Ethanol / Q000097:blood* / Q000494:pharmacology; D005260:Female; D005440:Fluid Therapy; D006400:Hematocrit; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D012189:Retrospective Studies; D014947:Wounds and Injuries
chemical_list: D000431:Ethanol