title: Impaired suppression of processing in schizophrenic patients suggested by ERPs obtained in a selective attention task.
abstract: In the present study, we focused on the ability of suppression of processing in schizophrenic patients, using event-related potentials (ERPs) recorded during a selective attention task. During the task, subjects were required to focus on one ear, counting deviant stimuli, those deviating in duration from a sequence of standard stimuli. We compared amplitude data of two positive components differing in latency elicited by standard stimuli, which reflect suppression of stimulus processing, between schizophrenic patients and normal controls. Significant between-group differences were obtained specifically in the right ear attended condition, suggesting impaired suppression of processing in schizophrenics mediated in the left hemisphere.
authors.affiliation: Department of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, 2-1-1 Kamikitazawa, Setagaya-ku, 156-0057, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kamio
authors.forename: K
authors.initials: K
authors.lastname: Nakagome
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: K
authors.initials: K
authors.lastname: Kasai
authors.forename: A
authors.initials: A
authors.lastname: Iwanami
authors.forename: K
authors.initials: K
authors.lastname: Hiramatsu
authors.forename: A
authors.initials: A
authors.lastname: Hata
authors.forename: A
authors.initials: A
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Fukuda
authors.forename: M
authors.initials: M
authors.lastname: Honda
authors.forename: N
authors.initials: N
authors.lastname: Kato
mesh_terms: D000328:Adult; D001288:Attention / Q000502:physiology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D007266:Inhibition, Psychological; D008297:Male; D010468:Perceptual Disorders / Q000175:diagnosis / Q000503:physiopathology*; D012559:Schizophrenia / Q000503:physiopathology*