title: Sarcoma in association with multimodality management of vulvar cancer: two case reports.
abstract: BACKGROUND
  Radiation-induced or -associated sarcoma is a rare event which has been well described in the literature. However, this entity has been infrequently described in association with genital tract malignancies. To our knowledge it has never been described in association with the management of vulvar cancer.
  
  
  METHODS
  . Two different cases of sarcoma developing after primary management for vulvar cancer are presented, the first being a case of angiosarcoma developing in the lower abdominal wall 36 months after initial therapy and the second a case of fibrosarcoma developing on the vulva 7 years after multimodality treatment.
  
  
  CONCLUSIONS
  Radiation-associated sarcoma after treatment for vulvar carcinoma is a rare event. A multimodality treatment of carcinoma of the vulva should not be withheld because of fear of sarcomagenesis.
authors.affiliation: Department of Gynaecology, Academic Medical Centre, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands.
authors.forename: S
authors.initials: S
authors.lastname: Hyde
authors.forename: L J
authors.initials: LJ
authors.lastname: Uitterhoeve
authors.forename: M S
authors.initials: MS
authors.lastname: Schilthuis
authors.forename: F J
authors.initials: FJ
authors.lastname: ten Kate
authors.forename: J
authors.initials: J
authors.lastname: van der Velden
mesh_terms: D000008:Abdominal Neoplasms / Q000209:etiology*; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005354:Fibrosarcoma / Q000209:etiology*; D006394:Hemangiosarcoma / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D016609:Neoplasms, Second Primary / Q000209:etiology*; D018714:Radiotherapy, Adjuvant / Q000009:adverse effects; D014846:Vulvar Neoplasms / Q000532:radiotherapy / Q000601:surgery / Q000628:therapy*