title: Induction of cross-protection in mice against dolphin Erysipelothrix rhusiopathiae isolates with a swine commercial vaccine.
abstract: Erysipelothrix rhusiopathiae is well known to cause disease in dolphins. This disease occurs either in an peracute way, leading to mortality even before clinical signs are observed or in a sub-acute way, characterized by rhomboidal skin lesions, that can be treated with penicillin or its derivatives. Commercial swine vaccines, containing inactivated serotype 2 strains, are currently used for vaccination but it is not known whether these vaccines induce protection against E. rhusiopathiae isolates from dolphins. In the present study, it was demonstrated in a mouse model that vaccination with a commercial swine vaccine (Eurovac Ery, Eurovet, Belgium) containing inactivated serotype 2 E. rhusiopathiae strains induced protection against challenge with three E. rhusiopathiae isolates from dolphins. The duration of the protection varied, depending on the challenging isolate, between 8 and >23 weeks. There was however no positive correlation between the amount of antibodies at the moment of challenge and the observed protection. In conclusion, vaccination trials in mice indicate that commercial serotype 2 swine Erysipelothrix vaccines induce protection against erysipelas caused by dolphin pathogenic isolates.
authors.affiliation: Marine Mammal Veterinary Services, Betferkerklaan 158, 8200 Brugge, Belgium. geraldine.lacave@skynet.be
authors.forename: G
authors.initials: G
authors.lastname: Lacave
authors.forename: E
authors.initials: E
authors.lastname: Cox
authors.forename: J
authors.initials: J
authors.lastname: Hermans
authors.forename: L
authors.initials: L
authors.lastname: Devriese
authors.forename: B M
authors.initials: BM
authors.lastname: Goddeeris
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood; D001428:Bacterial Vaccines / Q000276:immunology* / Q000592:standards; D003429:Cross Reactions / Q000276:immunology; D004289:Dolphins / Q000276:immunology* / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D004888:Erysipelothrix / Q000276:immunology*; D004889:Erysipelothrix Infections / Q000276:immunology* / Q000517:prevention & control; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D013552:Swine; D013554:Swine Erysipelas / Q000276:immunology; D014611:Vaccination / Q000662:veterinary
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines