Is periodontitis genetic? The answer may be Yes!
Specific bacteria cause periodontitis by activating immuno-inflammatory responses in the tissues. There are certain risk factors that significantly affect the disease process by altering the immuno-inflammatory response and increasing the likelihood of severe periodontitis. These risk factors are smoking, diabetes, IL-1 genotype, and perhaps others. Today about 20 percent of the population smokes at a level that should make a difference relative to periodontitis. About 30 to 33 percent of the Caucasian population is IL-1 genotype positive. There are compelling reasons to look at these risk factors in your practice to help formulate a complete treatment plan for your patients.
Kornman
K S
KS
Interleukin Genetics, Inc., Waltham, Massachusetts, USA.
Knobelman
C
C
Wang
H Y
HY
D016301:Alveolar Bone Loss / Q000209:etiology / Q000235:genetics; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000235:genetics; D009504:Neutrophils / Q000378:metabolism; D010518:Periodontitis / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects
D007375:Interleukin-1