title: Pancreatic concentrations of cefepime.
abstract: The concentrations of cefepime in pancreatic pseudocyst fluid (n = 4), pancreatic tissue (n = 4) and pancreatic fistula fluid (n = 1), and simultaneous plasma concentrations, were measured after intravenous administration of a single 2 g dose to nine patients. Mean plasma concentration was 27.4 mg/L between 120 and 200 min after the end of infusion. Mean pancreatic cefepime concentration was 6.3 mg/L in pseudocyst and 10.7 mg/L in pancreatic tissue. Cefepime was detected by 30 min after the end of the perfusion in pancreatic fistulae fluid, and persisted at 8 h. We conclude that cefepime is a potentially useful antibiotic in prevention and treatment of pancreatic infection.
authors.affiliation: Services d'Hépatogastroentérologie, Centre Hospitalo-Universitaire Nord, 80054 Amiens Cedex, France. delcenserie.richard@chu-amiens.fr
authors.forename: R
authors.initials: R
authors.lastname: Delcenserie
authors.forename: M P
authors.initials: MP
authors.lastname: Dellion-Lozinguez
authors.forename: T
authors.initials: T
authors.lastname: Yzet
authors.forename: B
authors.initials: B
authors.lastname: Lepointe
authors.forename: L
authors.initials: L
authors.lastname: Hary
authors.forename: R
authors.initials: R
authors.lastname: Badoui
authors.forename: P
authors.initials: P
authors.lastname: Verhaeghe
authors.forename: M
authors.initials: M
authors.lastname: Andrejak
authors.forename: J L
authors.initials: JL
authors.lastname: Dupas
mesh_terms: D000328:Adult; D000368:Aged; D000077723:Cefepime; D002511:Cephalosporins / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000378:metabolism* / Q000517:prevention & control
chemical_list: D002511:Cephalosporins; D000077723:Cefepime