Expression of the Thomsen-Friedenreich (TF) antigen in the human placenta.
The Thomsen-Friedenreich (TF) antigen (or, more precisely, epitope; Gal beta 1-3GalNAc-) has been known for a long time as a pancarcinoma antigen. Here we report the immunohistochemical identification of this carbohydrate antigen in the human placenta. Paraffin-embedded placental and decidual tissues of the first, second and third trimester were incubated with different monoclonal antibodies (A78-G/A7 and HH8) directed against the TF-epitope and stained with an immunohistochemistry system. We found a strong expression of the TF-epitope in the first trimester of pregnancy. In addition, we identified an expression of the TF-antigen in the second trimester of pregnancy but only in a few cases a positive staining in the third trimester of pregnancy.
Richter
D U
DU
University of Rostock, Department of Obstetrics and Gynaecology, Doberaner Str. 142, D-18055 Rostock, Germany.
Jeschke
U
U
Makovitzky
J
J
Goletz
S
S
Karsten
U
U
Briese
V
V
Friese
K
K
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000096:biosynthesis*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D010920:Placenta / Q000166:cytology / Q000378:metabolism*
D015295:Antigens, Tumor-Associated, Carbohydrate; C016467:Thomsen-Friedenreich antigen