title: Prevalence and phenotypes of erythromycin-resistant Streptococcus pneumoniae in Shanghai, China.
abstract: Bacterial resistance of Streptococcus pneumoniae against erythromycin and clindamycin and resistance phenotypes of erythromycin-resistant Streptococcus pneumoniae were investigated. The MICs of erythromycin and clindamycin against 345 strains of Streptococcus pneumoniae were tested with agar dilution method; the phenotypes of erythromycin-resistant Streptococcus pneumoniae were detected by double-disk test. One hundred and eighty-three and 171 of 345 (53.0% and 49.6%) of isolates had MICs > or =1 microg/ml for erythromycin and for clindamycin. Among erythromycin-resistant Streptococcus pneumoniae, the percentage of cMLS, iMLS and M phenotype was 90.3% (159/176), 5.7% (10/176) and 4.0% (7/176), respectively. The incidence of erythromycin-resistant Streptococcus pneumoniae is very high in Shanghai. The main phenotype is cMLS.
authors.affiliation: Institute of Antibiotics, Huashan Hospital, Medical Center of Fudan University (The Former Shanghai Medical University), 200040, Shanghai, People's Republic of China. wangminggui@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.forename: F
authors.initials: F
authors.lastname: Wang
mesh_terms: D002648:Child; D002675:Child, Preschool; D002681:China / Q000453:epidemiology; D002981:Clindamycin / Q000494:pharmacology*; D015169:Colony Count, Microbial; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D010641:Phenotype; D011008:Pneumococcal Infections / Q000453:epidemiology / Q000382:microbiology*; D015995:Prevalence; D013296:Streptococcus pneumoniae / Q000145:classification / Q000187:drug effects*
chemical_list: D002981:Clindamycin; D004917:Erythromycin