title: Novel non-peptide ligands for the somatostatin sst3 receptor.
abstract: A series of imidazole derivatives has been prepared using high throughput parallel synthesis. Several compounds showed high affinity (Ki in 10(-6)-10(-8) M range) and selectivity at recombinant human somatostatin receptor subtype 3 (hsst3).
authors.affiliation: Institut Henri Beaufour, Les Ulis, France. christophe.moinet@beaufour-ipsen.com
authors.forename: C
authors.initials: C
authors.lastname: Moinet
authors.forename: M O
authors.initials: MO
authors.lastname: Contour-Galcéra
authors.forename: L
authors.initials: L
authors.lastname: Poitout
authors.forename: B
authors.initials: B
authors.lastname: Morgan
authors.forename: T
authors.initials: T
authors.lastname: Gordon
authors.forename: P
authors.initials: P
authors.lastname: Rouber
authors.forename: C
authors.initials: C
authors.lastname: Thurieau
mesh_terms: D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites / Q000502:physiology; D016466:CHO Cells; D005576:Colforsin / Q000494:pharmacology*; D006224:Cricetinae; D000242:Cyclic AMP / Q000819:agonists* / Q000032:analysis / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology; D008024:Ligands; D009578:Nitrobenzenes / Q000138:chemical synthesis / Q000494:pharmacology*; D011485:Protein Binding / Q000502:physiology; D017481:Receptors, Somatostatin / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000037:antagonists & inhibitors; D013004:Somatostatin / Q000494:pharmacology*
chemical_list: D000577:Amides; D007093:Imidazoles; C429627:L796778; D008024:Ligands; D009578:Nitrobenzenes; D017481:Receptors, Somatostatin; D011994:Recombinant Proteins; C103631:somatostatin receptor 3; D005576:Colforsin; D013004:Somatostatin; D000242:Cyclic AMP