The pathophysiological role of prostaglandins in penile erection.
Penile erection is a complex haemodynamic event and relaxation of the vascular smooth muscle of the penis is fundamental to this process. This is primarily mediated by nitric oxide (NO) produced from non-adrenergic non-cholinergic (NANC) nerves and the endothelium surrounding the corporal sinusoids. However, corporal tissue has been shown to produce a number of other vasoactive factors, including prostaglandins (PGs), which appear to not only have diverse physiological effects, but are also able to modulate the effects of other neurotransmitters, including NO.
Minhas
S
S
Pyrah Department of Urology, St James's University Hospital, Leeds, UK.
Cartledge
J
J
Eardley
I
I
D003094:Collagen / Q000096:biosynthesis; D004730:Endothelium, Vascular / Q000502:physiology; D007172:Erectile Dysfunction / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D008297:Male; D010410:Penile Erection / Q000502:physiology*; D010413:Penis / Q000187:drug effects / Q000294:innervation / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology* / Q000627:therapeutic use; D015398:Signal Transduction
D011453:Prostaglandins; D003094:Collagen