title: Assessment of colorectal lesions using magnifying colonoscopy and mucosal dye spraying: can significant lesions be distinguished?
abstract: OBJECTIVE
  Assessing the nature of lesions at the time of colonoscopy is important, and magnifying colonoscopy allows examination of mucosal crypt patterns. In this study, we assessed mucosal crypt patterns to see whether we could predict the histological findings.
  
  
  METHODS
  This retrospective study of total colonoscopy using magnifying colonoscopy involved 4445 patients between December 1993 and July 1998 at the National Cancer Center Hospital East. The mucosal crypt patterns of 3438 lesions were observed under magnifying colonoscopy with 0.2% indigo carmine solution, and classified according to a modified Kudo classification (type I to V). After endoscopic or surgical resection (3291 cases and 147 cases, respectively), histopathological examination was performed.
  
  
  RESULTS
  The diagnostic accuracy of magnifying endoscopy for non-neoplastic lesions was 75% (117/157), for adenomatous polyps it was 94% (3006/3186), and for invasive carcinomas it was 85 % (81/95).
  
  
  CONCLUSIONS
  The combination of magnifying colonoscopy and dye spraying is helpful in determining the nature of colonic lesions as non-neoplastic, adenomas, or invasive carcinomas. Therefore it may be possible to determine, at the time of colonoscopy, which lesions require no treatment, which can be removed endoscopically, and which should be removed by surgery.
authors.affiliation: Dept. of Gastroenterology, National Cancer Center Hospital East, Kashiwa, Chiba, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Fujii
authors.forename: I
authors.initials: I
authors.lastname: Koba
authors.forename: Y
authors.initials: Y
authors.lastname: Sano
authors.forename: K I
authors.initials: KI
authors.lastname: Fu
authors.forename: A
authors.initials: A
authors.lastname: Parra-Blanco
authors.forename: H
authors.initials: H
authors.lastname: Tajiri
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: B
authors.initials: B
authors.lastname: Rembacken
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D000236:Adenoma / Q000473:pathology*; D001707:Biopsy, Needle; D020685:Colonoscopes; D003113:Colonoscopy / Q000379:methods*; D015179:Colorectal Neoplasms / Q000473:pathology*; D004396:Coloring Agents; D046508:Culture Techniques; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007089:Image Enhancement / Q000379:methods*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology*; D008297:Male; D008853:Microscopy; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D004396:Coloring Agents