title: Schizanrins [corrected] B, C, D, and E, four new lignans from Kadsura matsudai and their antihepatitis activities.
abstract: Bioassay-directed fractionation of ethanolic extract of Kadsura matsudai Hayata has resulted in the isolation of four novel C(18) dibenzocyclooctadiene lignans, schizanrin B (1), schizanrin C (2), schizanrin D (3), and schizanrin E (4). Schizanrin B (1) showed moderate to strong activity for antihepatitis in both anti-HBsAg and anti-HBeAg assays, and 3 and 4 also were active in the latter assay [corrected]. Compounds 1--4 were inactive in vitro against HIV replication in H9 lymphocytes. All new structures were elucidated using spectral analysis. Their structural elucidation by spectral and structure--activity relationships is also discussed.
authors.affiliation: National Research Institute of Chinese Medicine, 155-1, Sec. 2, Li-Nong Street, Shih-Pai, Taipei 112, Taiwan, Republic of China.
authors.forename: Y H
authors.initials: YH
authors.lastname: Kuo
authors.forename: S Y
authors.initials: SY
authors.lastname: Li
authors.forename: R L
authors.initials: RL
authors.lastname: Huang
authors.forename: M D
authors.initials: MD
authors.lastname: Wu
authors.forename: H C
authors.initials: HC
authors.lastname: Huang
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D002460:Cell Line; D006678:HIV / Q000187:drug effects / Q000502:physiology; D006507:Hepatovirus / Q000187:drug effects* / Q000502:physiology; D017705:Lignans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D017705:Lignans