[Postinfarction remodeling of the left atrium and left ventricle: effects of long-term treatment with beta adrenergic blockers and angiotensin converting enzyme inhibitors].
OBJECTIVE
To study changes in left atrial volume, geometry and function in myocardial infarction (MI) patients treated with beta-adrenoblocker and ACE inhibitor.


METHODS
65 patients with Q-wave myocardial infarction (MI) were followed up for 6 months. Regular check-ups included clinical examination, ECG, echo-CG, dopplercardiography.


RESULTS
In MI patients left ventricular remodeling is associated with left atrial remodeling. The greatest inhibition of remodeling in patients with symptoms of cardiac failure was reached with captopril therapy. Atenolol in this respect is less effective. If cardiac failure in MI patients is absent, atenolol impact on the remodeling is stronger than that of captopril.


CONCLUSIONS
In postmyocardial infarction patients remodeling occurs in both heart chambers. The presence of cardiac failure affects remodeling inhibition rate, especially under treatment with beta-adrenoblocker.
Mazur
N A
NA
Vikent'ev
V V
VV
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use; D001262:Atenolol / Q000008:administration & dosage / Q000627:therapeutic use*; D016279:Atrial Function, Left; D002216:Captopril / Q000008:administration & dosage* / Q000627:therapeutic use*; D003627:Data Interpretation, Statistical; D005260:Female; D005500:Follow-Up Studies; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D013997:Time Factors; D020257:Ventricular Remodeling
D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D001262:Atenolol; D002216:Captopril