Effect of menthone on the in vitro percutaneous absorption of tamoxifen and skin reversibility.
The effect of penetration enhancer (i.e., 1, 2, 3 and 5% menthone in combination with 50% ethanol (EtOH)) was investigated on the in vitro percutaneous absorption of tamoxifen, and post-recovery epidermal permeability after removal of the above enhancer. The flux of tamoxifen with menthone in combination with 50% EtOH was significantly greater (P<0.05) than the control (50% EtOH). The flux of tamoxifen increased with increasing concentrations of menthone. The post-recovery flux through enhancer exposed epidermis was significantly decreased (P<0.05) as compared to pre-recovery. However, post-recovery flux of tamoxifen through the enhancer-exposed epidermis did not completely recover to the baseline (i.e., post-recovery flux through phosphate buffered saline, pH 7.4 treated epidermis).
Zhao
K
K
Department of Pharmaceutical Sciences, College of Pharmacy, North Dakota State University, Fargo, ND 58105, USA.
Singh
S
S
Singh
J
J
D000287:Administration, Topical; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005079:Excipients; D066298:In Vitro Techniques; D008610:Menthol; D012869:Skin Absorption / Q000187:drug effects*; D013268:Stimulation, Chemical; D013552:Swine; D013629:Tamoxifen / Q000008:administration & dosage / Q000493:pharmacokinetics*; D013729:Terpenes / Q000494:pharmacology*
D018931:Antineoplastic Agents, Hormonal; D005079:Excipients; D013729:Terpenes; D013629:Tamoxifen; D008610:Menthol; C019466:menthone