title: A maternal inherited translocation t(1;22)(q11;p11) in two infertile brothers.
abstract: We report two infertile brothers presenting with azoospermia and oligozoospermia. Cytogenetic studies using G-banding and FISH analysis on lymphocyte cultures revealed an autosomal balanced reciprocal translocation t(1;22)(q11;p11) in both males. The same translocation was found in their mother, but not in a third fertile brother and maternal uncle suggesting that this translocation might compromise the male but not the female gametogenesis in this family.
authors.affiliation: Department of Genetics, Fundación Jimenez-Diaz, Madrid, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Lorda-Sanchez
authors.forename: C
authors.initials: C
authors.lastname: Tejedor
authors.forename: R
authors.initials: R
authors.lastname: Sanz
authors.forename: M
authors.initials: M
authors.lastname: Rodriguez de Alba
authors.forename: A
authors.initials: A
authors.lastname: de la Fuente
authors.forename: E
authors.initials: E
authors.lastname: Fernandez
authors.forename: C
authors.initials: C
authors.lastname: Ayuso
authors.forename: C
authors.initials: C
authors.lastname: Ramos
mesh_terms: D000328:Adult; D002878:Chromosomes, Human, Pair 1; D002880:Chromosomes, Human, Pair 11; D005260:Female; D006801:Humans; D008297:Male; D009035:Mothers; D009845:Oligospermia / Q000235:genetics*; D010375:Pedigree; D014178:Translocation, Genetic