Association between manganese superoxide dismutase (MnSOD) gene polymorphism and breast cancer risk.
Superoxide dismutases play a key role in the detoxification of superoxide radicals and thus protect cells from damage induced by free radicals. Within mitochondria manganese superoxide dismutase (MnSOD) provides a major defence against oxidative damage by reactive oxygen species. Polymorphism in the mitochondrial targeting sequence of MnSOD has recently been associated with risk of breast cancer. We examined this in a study population consisting of 483 breast cancer cases and 482 controls, all of Finnish Caucasian origin. Odds ratios (OR) and 95% confidence intervals (95% CIs) were estimated by unconditional logistic regression. MnSOD genotypes containing the variant A allele were found to be associated with a 1.5-fold (95% CI 1.1-2.0) increased risk of breast cancer compared with those with the homozygous wild-type genotype (MnSOD VV). This finding supports the proposal that MnSOD genotypes may modify individual breast cancer risk.
Mitrunen
K
K
Department of Industrial Hygiene and Toxicology, Finnish Institute of Occupational Health, Helsinki, Finland.
Sillanpää
P
P
Kataja
V
V
Eskelinen
M
M
Kosma
V M
VM
Benhamou
S
S
Uusitupa
M
M
Hirvonen
A
A
D001483:Base Sequence; D001943:Breast Neoplasms / Q000201:enzymology / Q000235:genetics*; D016022:Case-Control Studies; D017931:DNA Primers; D006801:Humans; D011110:Polymorphism, Genetic; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase / Q000235:genetics*
D017931:DNA Primers; D017382:Reactive Oxygen Species; D013482:Superoxide Dismutase