Paraneoplastic cerebellar degeneration heralding fallopian tube adenocarcinoma.
The objective of this paper is to describe an 81-year-old woman with subacute cerebellar degeneration due to fallopian tube adenocarcinoma. Serum anti-Yo antibodies were used to screen for pelvic malignancy. Their presence led to a meticulous search, which included bilateral salpingoophorectomy. Subsequently an occult fallopian tube adenocarcinoma was discovered. This case report highlights the diagnostic value of antineuroneal antibodies in females with subacute neurologic impairment in the form of paraneoplastic syndrome.
Levite
R
R
Department of Neurology, Sapir Medical Center - Meir General Hospital, Kfar-Saba, Israel.
Fishman
A
A
Kesler
A
A
Altaras
M
M
Gadoth
N
N
D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D000369:Aged, 80 and over; D000906:Antibodies; D001324:Autoantigens; D004268:DNA-Binding Proteins / Q000032:analysis / Q000276:immunology; D003937:Diagnosis, Differential; D005185:Fallopian Tube Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D009363:Neoplasm Proteins / Q000032:analysis / Q000276:immunology; D009382:Neoplasms, Unknown Primary / Q000150:complications*; D009419:Nerve Tissue Proteins; D020362:Paraneoplastic Cerebellar Degeneration / Q000209:etiology / Q000473:pathology*
D000906:Antibodies; D001324:Autoantigens; C063762:CDR1 protein, human; C095184:CDR2 protein, human; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins