Enzymes of carbohydrate metabolism as potential drug targets.
The potential for chemotherapeutic exploitation of carbohydrate metabolism in the Trypanosomatidae is reviewed. This review is based largely on discussions held at a meeting of the COST B9 Action, entitled 'Bioenergetics of Protozoan Parasites'. The major questions posed were: which enzymes are the best to target; what further information is required to allow their use for rational drug development; what compounds would constitute the best inhibitors and which of the enzymes of the pentose-phosphate pathway are present inside the glycosomes, as well? Only partial answers could be obtained in many cases, but the interactive discussion between the multidisciplinary group of participants, comprising chemists, biochemists and molecular biologists, provided thought-provoking ideas and will help direct future research.
Opperdoes
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FR
Christian de Duve Institute of Cellular Pathology, ICP-TROP 74/39, Avenue Hippocrate 74, B-1200, Brussels, Belgium. opperdoes@trop.ucl.ac.be
Michels
P A
PA
D000818:Animals; D050260:Carbohydrate Metabolism; D014355:Chagas Disease / Q000188:drug therapy; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects*; D014344:Trypanocidal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D014345:Trypanosoma / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism
D004791:Enzyme Inhibitors; D014344:Trypanocidal Agents