Chemokines and lymphopoiesis in human thymus.
Distinct and redundant chemokines are responsible for organizing the extraordinarily diverse thymocyte populations into discrete microenvironments, from the arrival of immature precursors in the thymus to the migration of different mature cell types to the periphery. We propose that, by selectively mobilizing cells, chemokines can sort positively selected cells from negatively selected cells, and that chemokines make distinctions among CD8+ subpopulations that previously have not been recognized.
Annunziato
F
F
Dept of Internal Medicine, Section of Immunoallergology and Respiratory Diseases, University of Florence, Viale Pieraccini 6, Florence-50134, Italy.
Romagnani
P
P
Cosmi
L
L
Lazzeri
E
E
Romagnani
S
S
D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D018925:Chemokines / Q000378:metabolism*; D006411:Hematopoiesis, Extramedullary / Q000276:immunology*; D006801:Humans; D018448:Models, Immunological; D019707:Receptors, Chemokine / Q000378:metabolism*; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*; D014018:Tissue Distribution
D018925:Chemokines; D019707:Receptors, Chemokine