Whole-body kinetics and dosimetry of cis-4-[(18)F]fluoro-L-proline.
The whole-body distribution of 4-cis[(18)F]fluoro-L-proline (cis-FPro) was studied in six patients with urological tumors by PET. Based on the IMEDOSE and MIRDOSE procedures radiation absorbed doses were estimated from whole-body PET scans acquired at 1 and 3-5 h after i.v. injection of 400 MBq cis-FPro. Cis-FPro showed high retention in the renal cortex and a slight uptake in liver and pancreas. Urinary excretion ranged from 12 to 19% at 5 h p.i. Highest absorbed doses were found for the urinary bladder wall and the kidneys (44.1/44.0 microGy/mbq). The effective dose according to ICRP 60 was 15.1 microSv/mbq for adults. This leads to an effective dose of 6.0 mSv in a PET study using 400 MBq cis-FPro.
Börner
A R
AR
Clinic of Nuclear Medicine, Heinrich-Heine-University Düsseldorf, FRG, Düsseldorf, Germany.
Langen
K J
KJ
Herzog
H
H
Hamacher
K
K
Müller-Mattheis
V
V
Schmitz
T
T
Ackermann
R
R
Coenen
H H
HH
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism; D010865:Pilot Projects; D011392:Proline / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D011874:Radiometry; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D019275:Radiopharmaceuticals; C431803:fluoro-proline; D011392:Proline