title: Mediator complexes and transcription.
abstract: Over the past decade, various components of the transcription machinery have been identified as potential targets for activators. Recently, metazoan versions of yeast Mediator have been isolated and found to act as key coactivators to many transcription factors. Recent work has defined the composition, function and biology of metazoan mediator complexes, which has led us to propose a new nomenclature for the variously named versions of the mediator complex.
authors.affiliation: Cell Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10021, USA.
authors.forename: C
authors.initials: C
authors.lastname: Rachez
authors.forename: L P
authors.initials: LP
authors.lastname: Freedman
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology; D004330:Drosophila / Q000196:embryology; D004625:Embryo, Nonmammalian / Q000196:embryology / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D046911:Macromolecular Substances; D056892:Mediator Complex; D009687:Nuclear Proteins / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000235:genetics / Q000302:isolation & purification / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*; D015003:Yeasts / Q000378:metabolism
chemical_list: C113182:DRIP, VDR interacting protein complex; C491863:MED4 protein, human; D046911:Macromolecular Substances; D056892:Mediator Complex; D009687:Nuclear Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors