The efficacy of Xialine in patients with xerostomia resulting from radiotherapy for head and neck cancer: a pilot-study.
Changes in subjective sensations due to xerostomia before and after administration of Xialine, a xanthan gum-based saliva substitute, were evaluated in 30 patients with radiation-induced xerostomia using the QLQ-H&N35. Xerostomia in general decreased with both Xialine and placebo to almost the same degree. A trend was seen for Xialine to improve problems with speech and senses.
Jellema
A P
AP
Department of Radiation Oncology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands.
Langendijk
H
H
Bergenhenegouwen
L
L
van der Reijden
W
W
Leemans
R
R
Smeele
L
L
Slotman
B J
BJ
D000368:Aged; D016009:Chi-Square Distribution; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D011878:Radiotherapy / Q000009:adverse effects; D012464:Saliva, Artificial / Q000627:therapeutic use*; D011795:Surveys and Questionnaires; D014987:Xerostomia / Q000188:drug therapy* / Q000209:etiology
D011135:Polysaccharides, Bacterial; D012464:Saliva, Artificial; C434189:xialine; C002563:xanthan gum