Cardiovascular actions of CRH and urocortin: an update.
Urocortin is a potent regulator of cardiac function, with actions that are prolonged in experimental animals. These changes are mediated via binding to CRH receptors found in peripheral tissues. The diversity of actions of urocortin on behaviour, appetite, inflammation and the cardiovascular system suggest that this peptide may be an endogenous factor mediating actions previously attributed to CRH. The present review will focus on the recent understanding of mechanisms mediating the cardiovascular actions of urocortin and CRH reported to date.
Parkes
D G
DG
Amylin Pharmaceuticals Inc., 9373 Towne Centre Drive, San Diego, CA 92121, USA. dparkes@amylin.com
Weisinger
R S
RS
May
C N
CN
D000818:Animals; D001066:Appetite / Q000187:drug effects / Q000502:physiology; D001519:Behavior / Q000187:drug effects / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects*; D003346:Corticotropin-Releasing Hormone / Q000737:chemistry / Q000494:pharmacology* / Q000502:physiology*; D006439:Hemodynamics / Q000187:drug effects / Q000502:physiology; D018019:Receptors, Corticotropin-Releasing Hormone / Q000737:chemistry / Q000502:physiology; D054832:Urocortins
D018019:Receptors, Corticotropin-Releasing Hormone; D054832:Urocortins; D003346:Corticotropin-Releasing Hormone