The impact of glycobiology on medicine.
Proteins essential to normal cell physiology are usually glycosylated and variation in their glycosylation patterns often leads to changes in their function. Changes in glycosylation pattern can also be associated with disease. It is now becoming increasingly clear how important it is to understand these changes, to gain insight into their involvement in disease mechanisms and the potential for novel therapeutic interventions.
Axford
J
J
Academic Unit for Musculoskeletal Disease, St George's Hospital Medical School, Cranmer Terrace, London, UK SW17 0RE. j.axford@sghms.ac.uk
D002851:Chromatography, High Pressure Liquid; D007562:Creutzfeldt-Jakob Syndrome / Q000209:etiology; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism*; D006084:Graft Rejection / Q000209:etiology; D013058:Mass Spectrometry; D008659:Metabolic Diseases / Q000209:etiology; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism*; D014183:Transplantation, Heterologous
D006023:Glycoproteins; D011134:Polysaccharides