Computer supported studies on design and evaluation of solid dispersions of carbamazepine.
The main advantages of solid dispersions (the drug could be maintained in a bioavailable form, dosage reduction and cleaner manufacturing conditions) provide scope for the continued interest in field. Additionally, their use in providing a sustained or controlled release of drugs has only been tentatively examined. In the present study, Carbamazepine has been used to develop a dosage form which will provide a booster amount followed by sustained release of the drug for effective control of epileptic seizures while keeping the serum level of the drug at minimum. Enteric polymers CAP and CAT have been used to retard the release till the formulation reaches the intestine. Either individually or combined fractions of the formulations may be used in the therapy of epilepsy.
Boral
A
A
Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
Ray
S
S
Das
B
B
Ghosh
L K
LK
Gupta
B K
BK
D000927:Anticonvulsants / Q000008:administration & dosage* / Q000737:chemistry*; D002220:Carbamazepine / Q000008:administration & dosage* / Q000737:chemistry*; D004055:Differential Thermal Analysis; D005079:Excipients; D011092:Polyethylene Glycols; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet
D000927:Anticonvulsants; D005079:Excipients; D002220:Carbamazepine; D011092:Polyethylene Glycols