title: Augmentation of prolactin secretion by estrogen in hypogonadal women.
abstract: The effect of estrogen on prolactin (PRL) release and gonadotropin suppression was assessed in six experiments performed on four hypogonadal women. Ethinyl estradiol at a dose of 1 microgram/kg per day induced a significant elevation of serum PRL levels within the 1st wk of treatment. There was a further rise until a plateau was reached in about 3-4 wk to levels of more than 3 times the initial concentration. This was accompanied by a pattern of increased episodic fluctuation. The corresponding serum luteinizing hormone and follicle-stimulating hormone fell progressively during the study period. These data indicate that a positive feedback relationship between estrogen and PRL release exists in humans.
authors.affiliation: Department of Reproductive Medicine, UCSD School of Medicine, La Jolla, California 92037, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Yen
authors.forename: Y
authors.initials: Y
authors.lastname: Ehara
authors.forename: T M
authors.initials: TM
authors.lastname: Siler
mesh_terms: D045166:Estradiol Congeners / Q000008:administration & dosage / Q000378:metabolism*; D004967:Estrogens / Q000494:pharmacology; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D011388:Prolactin / Q000097:blood / Q000378:metabolism*
chemical_list: D045166:Estradiol Congeners; D004967:Estrogens; D006062:Gonadotropins; D004997:Ethinyl Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone