Polymorphisms of tryptophan hydroxylase gene and the symptomatology of schizophrenia: an association study.
Serotonergic neurotransmission may be involved in the etiology of schizophrenia. We systematically searched for human tryptophan hydroxylase (TPH) coding polymorphisms, and detected a novel pentanucleotide repeat deletion polymorphism (GTTTT)4/5 in TPH intron 1b. We also confirmed A779C intron 7. Neither polymorphism showed a significant association with schizophrenia (182 patients with schizophrenia, 148 controls). A significant association, however, between A779C genotypes and the total Manchester Scale (MS) scores was found in male patients (P = 0.045). Subsequently, a significant association was also found between A779C genotypes and the MS negative symptoms scores in male patients (P = 0.030). These results suggest that the TPH gene may play a role in the negative symptoms in male patients with schizophrenia.
Shinkai
T
T
Department of Psychiatry, School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan. shinkai@med.uoeh-u.ac.jp
Ohmori
O
O
Suzuki
T
T
Kojima
H
H
Hori
H
H
Terao
T
T
Nakamura
J
J
D000483:Alleles; D001483:Base Sequence; D004247:DNA / Q000737:chemistry / Q000235:genetics; D017931:DNA Primers; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007438:Introns; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012016:Reference Values; D012091:Repetitive Sequences, Nucleic Acid; D015183:Restriction Mapping; D012559:Schizophrenia / Q000235:genetics*; D012565:Schizophrenic Psychology; D017384:Sequence Deletion; D014365:Tryptophan Hydroxylase / Q000235:genetics*
D017931:DNA Primers; D004247:DNA; D014365:Tryptophan Hydroxylase