title: Central and extrapontine myelinolysis in a patient in spite of a careful correction of hyponatremia.
abstract: We report the case of a 54-year-old alcoholic female patient who was hospitalized for neurologic alterations along with a severe hyponatremia (plasma Na+: 97 mEq/l). She suffered from potomania and was given, a few days before admission, a thiazide diuretic for hypertension. A careful correction of plasma Na+ levels was initiated over a 48-hour period (rate of correction < 10 mEq/l/24h) in order to avoid brain demyelination. After a 2-day period of clinical improvement, her neurologic condition started to deteriorate. By the 5th day of admission, she became tetraplegic, presented pseudobulbar palsy, ataxia, strabism, extrapyramidal stiffness and clouding of consciousness. Scintigraphic and MRI investigations demonstrated pontine and extrapontine lesions associated with Gayet-Wernicke encephalopathy. After correction of ionic disorders (hyponatremia, hypokaliemia) and vitamin B (thiamine) deficiency, the patient almost completely recovered without notable disabilities. This case illustrates that profound hyponatremia, in a paradigm of slow onset, can be compatible with life. It also demonstrates that demyelinating lesions, usually considered as a consequence of a too fast correction of hyponatremia, may occur despite the strict observance of recent guidelines. There is increasing evidence to suggest that pontine swelling and dysfunction may sometimes occur in alcoholic patients even in absence of disturbance in plasma Na+ levels. It is therefore of importance, while managing a hyponatremic alcoholic patient, to identify additional risk factors (hypokaliemia, hypophosphoremia, seizure-induced hypoxemia, malnutrition with vitamin B deficiency) for brain demyelination and to correct them appropriately.
authors.affiliation: Department of Internal Medicine, CHR-St Joseph Medical Center, Mons, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: Leens
authors.forename: R
authors.initials: R
authors.lastname: Mukendi
authors.forename: F
authors.initials: F
authors.lastname: Forêt
authors.forename: A
authors.initials: A
authors.lastname: Hacourt
authors.forename: O
authors.initials: O
authors.lastname: Devuyst
authors.forename: I M
authors.initials: IM
authors.lastname: Colin
mesh_terms: D019973:Alcohol-Related Disorders / Q000628:therapy*; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000150:complications* / Q000628:therapy*; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D017590:Myelinolysis, Central Pontine / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D011877:Radionuclide Imaging; D012307:Risk Factors; D012964:Sodium / Q000097:blood
chemical_list: D012964:Sodium