Testing for endocrine disruption post-EDSTAC: extrapolation of low dose rodent effects to humans.
The study of chemically-induced endocrine disruption in mammals is a relatively new field of endeavour, and it has been assailed by an unusual level of disagreement among investigators regarding the developmental effects produced by chemicals in animals. This article discusses the several sources of uncertainty in endocrine toxicity studies, and the intrinsic variability of many of the key experimental parameters. It is concluded that current uncertainties regarding extrapolation of rodent effects to humans are due to the absence of an extensive agreed rodent control database for the developmental parameters under study, coupled to the established intrinsic variability of these parameters between strains/species of test animals and test protocols. Only when these factors are generally accepted and well studied will it be possible to relate effects seen in rodents to humans.
Ashby
J
J
Syngenta Central Toxicology Laboratory, Alderley Park, Cheshire SK10 4TJ, Macclesfield, UK . john.ashby@syngenta.com
D000818:Animals; D001559:Benzhydryl Compounds; D004032:Diet; D004054:Diethylstilbestrol / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004702:Endocrine Glands / Q000187:drug effects*; D005260:Female; D005333:Fetus / Q000187:drug effects; D005835:Genitalia / Q000187:drug effects*; D006801:Humans; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000633:toxicity; D051381:Rats; D013045:Species Specificity; D000098826:Bisphenol A Compounds
D001559:Benzhydryl Compounds; D004054:Diethylstilbestrol; D010636:Phenols; C006780:bisphenol A; D000098826:Bisphenol A Compounds