title: Renal parenchymal injury after standard and mini percutaneous nephrostolithotomy.
abstract: OBJECTIVE
  Mini percutaneous nephrostolithotomy was developed for use in children and in adults with a reduced renal reserve to minimize the morbidity and renal parenchymal damage presumed to occur with traditional percutaneous nephrostolithotomy. We compared the extent of renal injury incurred by different sized nephrostomy tracts in female farm pigs undergoing 11 or 30Fr percutaneous nephrostomy.
  
  
  METHODS
  Bilateral percutaneous nephrostomy was attempted via a mid or lower pole calix under fluoroscopic guidance in 6 pigs. In 2 pigs the procedure was unsuccessful on 1 side, leaving 5 successfully established nephrostomy tracts on each side. In each pig the right percutaneous tract was dilated with a 28Fr dilating balloon and a 30Fr Amplatz working sheath (Cook Urological, Spencer, Indiana) was positioned in the collecting system. On the left side an 11Fr sheath (Cook Urological) was placed. The sheaths were removed after 1 hour and nephrostomy tubes (22Fr on the right and 8Fr on the left side) were left in place overnight and then removed. Six weeks later the pigs were sacrificed and the kidneys were harvested. The nephrostomy tracts were identified grossly and examined microscopically, and the fibrotic scar was measured using digital analysis. The volume of scar was estimated using the calculated volume of a cylinder.
  
  
  RESULTS
  At kidney harvest all 10 kidneys appeared grossly normal. No intra-abdominal urine collection or perirenal hematoma was noted. Mean estimated scar volume of the 30 and 11Fr tracts was 0.29 and 0.40 cc, which translates into a mean fractional loss of parenchyma of 0.63% and 0.91%, respectively (p not significant).
  
  
  CONCLUSIONS
  Renal parenchymal damage resulting from the creation of a nephrostomy tract is small compared to overall renal volume regardless of the size of the nephrostomy tract. Consequently there is no advantage to the use of a small access sheath based on renal scarring alone.
authors.affiliation: Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas, USA.
authors.forename: O
authors.initials: O
authors.lastname: Traxer
authors.forename: T G
authors.initials: TG
authors.lastname: Smith
authors.forename: M S
authors.initials: MS
authors.lastname: Pearle
authors.forename: T S
authors.initials: TS
authors.lastname: Corwin
authors.forename: H
authors.initials: H
authors.lastname: Saboorian
authors.forename: J A
authors.initials: JA
authors.lastname: Cadeddu
mesh_terms: D000818:Animals; D002404:Catheterization / Q000295:instrumentation; D002921:Cicatrix / Q000209:etiology / Q000473:pathology; D005260:Female; D007668:Kidney / Q000293:injuries* / Q000473:pathology; D019060:Minimally Invasive Surgical Procedures; D009403:Nephrostomy, Percutaneous / Q000009:adverse effects* / Q000379:methods; D013552:Swine