PD-1: an inhibitory immunoreceptor involved in peripheral tolerance.
PD-1 deficiency causes a variety of autoimmune diseases. Inhibitory signaling through the PD-1 receptor might therefore be involved in the regulation of peripheral tolerance. The constitutive expression of PD-1 ligands (PD-L1 and PD-L2) on parenchymal cells of heart, lung and kidney suggests that the PD-1-PD-L system could provide unique negative signaling to help prevent autoimmune diseases.
Nishimura
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H
Department of Medical Chemistry, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-ku, Kyoto, 606-8501, Japan.
Honjo
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T
D000818:Animals; D015703:Antigens, CD; D000954:Antigens, Surface / Q000378:metabolism*; D051017:Apoptosis Regulatory Proteins; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D018122:B7-1 Antigen; D018106:CD28 Antigens; D002311:Cardiomyopathy, Dilated / Q000209:etiology / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D008024:Ligands; D051379:Mice; D018448:Models, Immunological; D061026:Programmed Cell Death 1 Receptor; D011971:Receptors, Immunologic / Q000378:metabolism*; D015398:Signal Transduction
D015703:Antigens, CD; D000954:Antigens, Surface; D051017:Apoptosis Regulatory Proteins; D018122:B7-1 Antigen; D018106:CD28 Antigens; D008024:Ligands; C105992:PDCD1 protein, human; C491383:Pdcd1 protein, mouse; D061026:Programmed Cell Death 1 Receptor; D011971:Receptors, Immunologic