title: [Use of sildenafil in the chronic uremic patient].
abstract: BACKGROUND
  Erectile dysfunction is one of the factors influencing negatively the quality of life of patients in hemodialytic treatment. The international literature shows that erectile dysfunction is present in 30% of patients with chronic renal failure and in 50% of patients undergoing dialytic treatment. Fertility, libido and erectile dysfunction, suffer progressive worsening with time, in spite of hemodialysis. The availability of a drug like Sildenafil can improve the quality of life of the patient and give him a normal sexual activity.
  
  
  METHODS
  Twenty patients between 29 and 51 years, were selected; 2 of these had been subjected to renal transplant, with a dialytic treatment time varying from 3 to 13 years. Before the treatment all the patients have been subjected to an andrological screening (testosterone, prolactin, penile color Doppler ultrasound) and proposed the IIEF test. Therapeutic strategy included the assumption of the drug in the days in which the patients were not subjected to dialysis, with an interval from 1 to 3 weeks between assumption and another. The dose was 25-50 mg. At the end of three months of therapy the patients were again subjected to the IIEF test.
  
  
  RESULTS
  All patients reported an improvement in sexual activity and sexual desire with very good repercussions on general and psychophysical conditions.
  
  
  CONCLUSIONS
  The results demonstrate at least that Sildenafil is also effective in uremic patients in dialytic treatment or after renal transplant and that it can therefore resolve one of the main problems for the normal development of the life of such patients.
authors.affiliation: Dipartimento di Urologia U. Bracci, Università degli Studi La Sapienza, Rome, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Punzo
authors.forename: S
authors.initials: S
authors.lastname: Maggi
authors.forename: R
authors.initials: R
authors.lastname: Ponzio
authors.forename: M
authors.initials: M
authors.lastname: Costarella
authors.forename: V
authors.initials: V
authors.lastname: Gentile
mesh_terms: D000328:Adult; D002908:Chronic Disease; D007172:Erectile Dysfunction / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010726:Phosphodiesterase Inhibitors / Q000627:therapeutic use*; D010879:Piperazines / Q000627:therapeutic use*; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D014511:Uremia / Q000209:etiology
chemical_list: D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D000068677:Sildenafil Citrate