The in vitro effect of imipenem and ofloxacin on enzymic activity of Klebsiella strains.
Fifty seven Klebsiella strains, viz. K. pneumoniae (28), K. planticola (19), K. oxytoca (6), K. ornithinolytica (3) and K. terrigena (1) possessed lipolytic and urealytic activity. The effect of imipenem and ofloxacin at subinhibitory concentrations (sub-MICs) on these enzymic activities of 4 strains was studied. At all the concentrations tested (mainly at 1/4 of the MICs) imipenem enhanced lipase activity manifested by cleavage of the substrate Tween 20. The effect of ofloxacin was strain- and concentration-dependent but in most cases lipolytic activity was also increased. The antibiotics practically did not affect the urease activity of the strains.
Hostacká
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Institute of Preventive and Clinical Medicine, 833 01 Bratislava, Slovakia.
D000890:Anti-Infective Agents / Q000494:pharmacology*; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D007709:Klebsiella / Q000145:classification / Q000187:drug effects* / Q000201:enzymology*; D007710:Klebsiella Infections / Q000382:microbiology; D008049:Lipase / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D013845:Thienamycins / Q000494:pharmacology*; D014510:Urease / Q000378:metabolism
D000890:Anti-Infective Agents; D013845:Thienamycins; D015378:Imipenem; D015242:Ofloxacin; D008049:Lipase; D014510:Urease