title: [Optoacoustic tissue alterations for optimizing laser cyclophotocoagulation. Transscleral detection of laser-induced optoacoustic pressure transients].
abstract: BACKGROUND
  Considerable problems occur in transscleral laser cyclophotocoagulation concerning energy dosage. We investigated the feasibility of localizing the ciliary body by the detection of thermoelastic pressure transients and of supervising on-line the degree of tissue damage during treatment.
  
  
  METHODS
  We used a specially designed handpiece to apply short pulsed laser radiation with low energy levels to enucleated bulbs of rabbits. With an adjusted pressure transducer we examined acoustical transients generated in the area of absorption of the ciliary muscle or the pigmented epithelial layer and measured axial resolution of the method at various distances to the corneoscleral limbus.
  
  
  RESULTS
  We detected acoustic transients that allowed rough localization of the target area. A marked change in signal was recorded with increasing level of ciliary destruction.
  
  
  CONCLUSIONS
  This procedure can serve as an essential tool in the on-line supervision of the coagulation process. The laser parameters can thus be adjusted optimally to the progress of the treatment.
authors.affiliation: Laser Zentrum Hannover e.V., Hollerithallee 8, 30169 Hannover. BD@LZH.DE
authors.forename: I A
authors.initials: IA
authors.lastname: Bruder
authors.forename: A
authors.initials: A
authors.lastname: Büsching
authors.forename: U
authors.initials: U
authors.lastname: Oberheide
authors.forename: H
authors.initials: H
authors.lastname: Lubatschowski
authors.forename: H
authors.initials: H
authors.lastname: Welling
authors.forename: W
authors.initials: W
authors.lastname: Ertmer
mesh_terms: D000162:Acoustics; D000818:Animals; D016477:Artifacts; D002924:Ciliary Body / Q000601:surgery; D005901:Glaucoma / Q000601:surgery*; D066298:In Vitro Techniques; D017075:Laser Coagulation / Q000295:instrumentation; D055095:Optics and Photonics; D011817:Rabbits; D012590:Sclera; D014159:Transducers