Dimeric L-dopa derivatives as potential prodrugs.
A series of dimeric derivatives (+)-1, and (+)-2, and (+)-3a-d of L-Dopa diacetyl esters was synthesized and evaluated as potential L-Dopa prodrugs with improved physicochemical properties. All the new compounds showed chemical stability in aqueous buffer solutions (pH 1.3 and 7.4). A relatively slow release of L-Dopa in human plasma was observed.
Di Stefano
A
A
Dipartimento di Scienze del Farmaco, Università G. D'Annunzio, Chieti, Italy. adistefano@unich.it
Mosciatti
B
B
Cingolani
G M
GM
Giorgioni
G
G
Ricciutelli
M
M
Cacciatore
I
I
Sozio
P
P
Claudi
F
F
D000818:Animals; D019281:Dimerization; D004355:Drug Stability; D006207:Half-Life; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007980:Levodopa / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D010949:Plasma / Q000378:metabolism; D011355:Prodrugs / Q000138:chemical synthesis* / Q000493:pharmacokinetics*; D051381:Rats
D011355:Prodrugs; D007980:Levodopa