[The research of receptor-mediated drug carrier].
One way to increase the concentration of drug in diseased tissue is to attach drug to a suitable carrier such as protein or peptides, which can improve the pharmacokinetic properties of drug and decrease it's side-effect on normal tissue. The developments of receptor-mediated transporting of drug assotiated with protein or peptides are reviewed in this paper. The most frequently used receptors and drug carriers and the bonds between the drug and the carrier are introduced. The machanism of transporting and the factors that affect the efficiency of the drug carrier are discussed as well.
Ding
H
H
Department of Nuclear Medicine, First University Hospital, West China University of Medical Science, Chengdu 610041.
Kuang
A
A
D004337:Drug Carriers / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D011956:Receptors, Cell Surface / Q000502:physiology
D004337:Drug Carriers; D010455:Peptides; D011506:Proteins; D011956:Receptors, Cell Surface