Anxiolytic-like effect of nafadotride and PNU 99194A, dopamine D3 receptor antagonists in animal models.
The obtained results indicate that dopamine D3 receptor antagonists, nafadotride and PNU 99194A, produced anxiolytic-like effect in animal models, which suggests a putative role of these drugs in the therapy of anxiety.
Rogóz
Z
Z
Department of Pharmacology, Polish Academy of Sciences, Kraków.
Kłodzińska
A
A
Maj
J
J
D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001007:Anxiety / Q000523:psychology*; D001522:Behavior, Animal / Q000187:drug effects*; D003220:Conflict, Psychological; D003975:Diazepam / Q000494:pharmacology; D018492:Dopamine Antagonists / Q000494:pharmacology*; D065127:Dopamine D2 Receptor Antagonists; D004326:Drinking / Q000187:drug effects; D004597:Electroshock; D005106:Exploratory Behavior / Q000187:drug effects; D007189:Indans / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009281:Naphthalenes / Q000494:pharmacology*; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D050637:Receptors, Dopamine D3
D014151:Anti-Anxiety Agents; D018492:Dopamine Antagonists; D065127:Dopamine D2 Receptor Antagonists; C493594:Drd3 protein, mouse; C493595:Drd3 protein, rat; D007189:Indans; D009281:Naphthalenes; D011759:Pyrrolidines; D050637:Receptors, Dopamine D3; C086335:(5,6-dimethoxyindan-2-yl)dipropylamine; C097285:nafadotride; D003975:Diazepam