title: A prospective randomized trial comparing clomiphene citrate with tamoxifen citrate for ovulation induction.
abstract: OBJECTIVE
  To compare the rates of ovulation and pregnancy after tamoxifen citrate (TMX) or clomiphene citrate (CC) among anovulatory women with infertility.
  
  
  METHODS
  Prospective randomized trial.
  
  
  METHODS
  Infertility clinic in a university teaching hospital.
  
  
  METHODS
  Eighty-six anovulatory women under 40 years of age undergoing ovulation induction.
  
  
  METHODS
  The women were assigned randomly to receive either TMX or CC on cycle days 5-9.
  
  
  METHODS
  Rates of ovulation and pregnancy for the two treatment modalities.
  
  
  RESULTS
  The overall rate of ovulation in the TMX group was 50 of 113 (44.2%) and in the CC group, 41 of 91 (45.1%). There were 10 pregnancies in the TMX group and 6 pregnancies in the CC group. The cycle fecundity per ovulatory cycle was 20.0% in the TMX group and 14.6% in the CC group.
  
  
  CONCLUSIONS
  The overall rate of ovulation and pregnancy were similar with TMX and CC. TMX is a suitable alternative agent to CC in the management of anovulatory infertility.
authors.affiliation: Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, University of Southern California Keck School of Medicine, Los Angeles, California 90033, USA.
authors.forename: R
authors.initials: R
authors.lastname: Boostanfar
authors.forename: J K
authors.initials: JK
authors.lastname: Jain
authors.forename: D R
authors.initials: DR
authors.lastname: Mishell
authors.forename: R J
authors.initials: RJ
authors.lastname: Paulson
mesh_terms: D000328:Adult; D002996:Clomiphene / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000652:urine; D008297:Male; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate; D011446:Prospective Studies; D020845:Selective Estrogen Receptor Modulators / Q000008:administration & dosage / Q000627:therapeutic use*; D013629:Tamoxifen / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; D002996:Clomiphene; D007986:Luteinizing Hormone