title: Connective tissue disease after hip and knee implant surgery.
abstract: OBJECTIVE
  To increase the knowledge of the long-term effects of artificial hip and knee joint implants.
  
  
  METHODS
  The study groups consisted of 24,636 patients with osteoarthritis who underwent hip implant surgery and 5,221 who received knee implants during 1977-89. The post-implant rate of hospitalization for connective tissue disease (CTD) was compared with the rate in the general population of Denmark and with that among osteoarthritis patients without implant surgery.
  
  
  RESULTS
  The rates of hospitalization for CTD were higher than the background level among both hip and knee implant patients with osteoarthritis, whereas the comparison with non-implanted osteoarthritis patients revealed that the hospitalization rate for CTD was reduced after hip implant surgery, but increased after knee implant surgery.
  
  
  CONCLUSIONS
  Since the materials used in hip and knee implants in Denmark are not substantially different, these results are unlikely to reflect an implant effect but rather the selection criteria of referral for implant surgery.
authors.affiliation: Institute of Cancer Epidemiology, Danish Cancer Society, Copenhagen. lene@cancer.dk
authors.forename: L
authors.initials: L
authors.lastname: Mellemkjaer
authors.forename: S
authors.initials: S
authors.lastname: Friis
authors.forename: J K
authors.initials: JK
authors.lastname: McLaughlin
authors.forename: B L
authors.initials: BL
authors.lastname: Thomsen
authors.forename: K
authors.initials: K
authors.lastname: Kjøller
authors.forename: C
authors.initials: C
authors.lastname: Høgsted
authors.forename: J F
authors.initials: JF
authors.lastname: Winther
authors.forename: W J
authors.initials: WJ
authors.lastname: Blot
authors.forename: J H
authors.initials: JH
authors.lastname: Olsen
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D015331:Cohort Studies; D003240:Connective Tissue Diseases / Q000453:epidemiology / Q000209:etiology*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008297:Male; D008875:Middle Aged; D015207:Osteoarthritis, Hip / Q000601:surgery; D020370:Osteoarthritis, Knee / Q000601:surgery; D019919:Prosthesis Implantation / Q000009:adverse effects*; D012042:Registries