Drug-nutrient interactions in transplant recipients.
Drug-nutrient interaction refers to an alteration of kinetics or dynamics of a drug or a nutritional element, or a compromise in nutritional status as a result of the addition of a drug. The potentials for drug-nutrient interaction increase with the number of drugs taken by the patient. Organ transplant recipients are therefore at high risk for drug-nutrient interactions because multiple medications are used to manage graft rejection, opportunistic infections, and other associated complications. Unrecognized or unmanaged drug-nutrient interactions in this patient population can have an adverse impact on their outcomes. This paper reviews the importance of recognizing drug-nutrient interaction when using cyclosporine-based regimens.
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Department of Pharmacy Practice & Medicine, Colleges of Pharmacy and Medicine, University of Illinois at Chicago, 60612, USA. neander@uic.edu
D016572:Cyclosporine / Q000009:adverse effects*; D018565:Food-Drug Interactions; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007408:Intestinal Absorption / Q000187:drug effects*; D009752:Nutritional Status / Q000187:drug effects; D016377:Organ Transplantation; D010599:Pharmacokinetics; D011183:Postoperative Complications; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D016572:Cyclosporine