A retrotransposon-derived gene, PEG10, is a novel imprinted gene located on human chromosome 7q21.
A novel paternally expressed imprinted gene, PEG10 (Paternally Expressed 10), was identified on human chromosome 7q21. PEG10 is located near the SGCE (Sarcoglycan epsilon) gene, whose mouse homologue was recently shown to be imprinted. Therefore, it is highly possible that a new imprinted gene cluster exists on human chromosome 7q21. Analysis of two predicted open reading frames (ORF1 and ORF2) revealed that ORF1 and ORF2 have homology to the gag and pol proteins of some vertebrate retrotransposons, respectively. These data suggest that PEG10 is derived from a retrotransposon that was previously integrated into the mammalian genome. PEG10 is likely to be essential for understanding how exogenous genes become imprinted.
Ono
R
R
Gene Research Center, Tokyo Institute of Technology, 4259 Nagatsuta-cho, Midori-ku, Yokohama 226-8501, Japan.
Kobayashi
S
S
Wagatsuma
H
H
Aisaka
K
K
Kohda
T
T
Kaneko-Ishino
T
T
Ishino
F
F
D000595:Amino Acid Sequence; D000818:Animals; D051017:Apoptosis Regulatory Proteins; D002822:Choriocarcinoma / Q000235:genetics; D002897:Chromosomes, Human, Pair 7; D004268:DNA-Binding Proteins; D005260:Female; D015750:Genes, gag / Q000235:genetics; D015751:Genes, pol / Q000235:genetics; D018392:Genomic Imprinting; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000235:genetics; D016366:Open Reading Frames; D020161:Physical Chromosome Mapping / Q000379:methods; D011110:Polymorphism, Genetic; D011506:Proteins / Q000235:genetics*; D016601:RNA-Binding Proteins; D021101:Radiation Hybrid Mapping / Q000379:methods; D018626:Retroelements; D017386:Sequence Homology, Amino Acid; D013577:Syndrome; D014157:Transcription Factors / Q000235:genetics
D051017:Apoptosis Regulatory Proteins; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; C432965:PEG10 protein, human; C110780:Peg10 protein, mouse; D011506:Proteins; D016601:RNA-Binding Proteins; D018626:Retroelements; D014157:Transcription Factors