Acute pancreatitis associated with interferon alpha therapy for chronic myelogenous leukemia.
Acute pancreatitis related to interferon alpha therapy is very rare. We report two patients with chronic myelogenous leukemia (CML) who developed acute pancreatitis following treatment with interferon alpha. A review of the literature on the association of pancreatitis and interferon alpha is provided. Possible pathophysiologic mechanisms are also discussed.
Tannir
N M
NM
Department of Leukemia, the University of Texas MD Anderson Cancer Center, Houston, Texas 77030 USA.
Talpaz
M
M
Ghazal
H
H
Proothi
S
S
Kantarjian
H M
HM
D000208:Acute Disease; D000328:Adult; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed
D016898:Interferon-alpha