title: Mechanisms of cisapride affecting gallbladder motility.
abstract: Regulation of gallbladder motility is complex. Mechanisms via which cisapride may interact with gallbladder function are being reviewed. These are multiple and include direct effects on gallbladder and the sphincter of oddi, as well as indirect effects involving gastro-intestinal hormone levels, gastric emptying, gallbladder refilling, interdigestive migrating motor cycle (IMMC) and small intestinal transit. Effects, moreover, may vary according to dose, route and duration of cisapride administration, which may explain conflicting data so far with cisapride.
authors.affiliation: Department of Gastroenterology, Bundeswherzentralkrankenhaus, Koblenz, Germany.
authors.forename: R
authors.initials: R
authors.lastname: von Kiedrowski
authors.forename: S
authors.initials: S
authors.lastname: Huijghebaert
authors.forename: R
authors.initials: R
authors.lastname: Raedsch
mesh_terms: D020117:Cisapride / Q000494:pharmacology*; D005704:Gallbladder / Q000187:drug effects* / Q000502:physiology*; D005746:Gastric Emptying / Q000502:physiology; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D005768:Gastrointestinal Hormones / Q000502:physiology; D006801:Humans
chemical_list: D005765:Gastrointestinal Agents; D005768:Gastrointestinal Hormones; D020117:Cisapride