A simple and inexpensive preparation of [(51)Cr]-MAA particles.
The feasibility of preparing [(51)Cr]-MAA was investigated using an MAA cold kit and commercially available sodium [(51)Cr]chromate solutions. Of different conditions tested, the best required an addition of a low level of sodium dithionite to achieve a radiolabeling efficiency of 44%. The product was purified by centrifugation to give [(51)Cr]-MAA with 99 +/- 1% radiochemical purity (RCP) comprised of >94% radioactive particles >10 microm, and resulted in a rat biodistribution with >80% in the lungs. [(51)Cr]-MAA is inexpensive, easily and conveniently prepared by this procedure.
Tsopelas
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RAH Radiopharmacy, Royal Adelaide Hospital, North Terrace, 5000, Adelaide, Australia. ctsopela@mail.rah.se.gov.au
Brundell
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Chatterton
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D000418:Albumins / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D000818:Animals; D002860:Chromium Radioisotopes / Q000737:chemistry / Q000493:pharmacokinetics; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D010316:Particle Size; D011854:Radiochemistry; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D014018:Tissue Distribution
D000418:Albumins; D002860:Chromium Radioisotopes; D019275:Radiopharmaceuticals; C075321:macro aggregates of albumin