title: A dynamic adaptation of the propensity score adjustment for effectiveness analyses of ordinal doses of treatment.
abstract: The propensity score adjustment is a method to reduce bias in observational studies. We propose a strategy that involves a novel combination of three data analytic techniques, which adapts the propensity adjustment for additional perturbations of longitudinal, observational studies. First, ordinal logistic regression examines propensity for ordinal doses of treatment. Second, a mixed-model approach incorporates the multiple treatment trials and multiple episodes that are characteristic of chronically ill subjects. Finally, a mixed-effects grouped-time survival model incorporates the propensity score in treatment effectiveness analyses. The strategy that is applied here to an observational study of affective illness can also be used to evaluate the effectiveness of treatments for other chronic illnesses.
authors.affiliation: Cornell University Medical College, Department of Psychiatry, Box 140, 525 East 68th Street, New York, NY 10021, USA. acleon@mail.med.cornell.edu
authors.forename: A C
authors.initials: AC
authors.lastname: Leon
authors.forename: T I
authors.initials: TI
authors.lastname: Mueller
authors.forename: D A
authors.initials: DA
authors.lastname: Solomon
authors.forename: M B
authors.initials: MB
authors.lastname: Keller
mesh_terms: D000293:Adolescent; D000328:Adult; D000928:Antidepressive Agents / Q000008:administration & dosage / Q000627:therapeutic use; D003627:Data Interpretation, Statistical; D003863:Depression / Q000188:drug therapy; D006801:Humans; D016015:Logistic Models; D008137:Longitudinal Studies; D015337:Multicenter Studies as Topic; D015588:Observer Variation; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis; D016896:Treatment Outcome
chemical_list: D000928:Antidepressive Agents