title: Antidiabetic activity of a xanthone compound, mangiferin.
abstract: Mangiferin (MF) isolated from Anemarrhena asphodeloides Bunge rhizome, was tested for antidiabetic activity in KK-Ay mice, an animal model of type-2 diabetes. MF lowered the blood glucose level of KK-Ay mice 3 weeks after oral administration (p < 0.01). However, no effect on the blood glucose level in normal mice was seen, indicating that MF could be useful in treating type-2 diabetes. In addition, MF improved hyperinsulinemia and, on insulin tolerance test, reduced blood glucose levels of KK-Ay mice. From these findings, it seems likely that MF exerts its antidiabetic activity by decreasing insulin resistance.
authors.affiliation: Suzuka University of Medical Science, Mie, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Ichiki
authors.forename: I
authors.initials: I
authors.lastname: Hashimoto
authors.forename: N
authors.initials: N
authors.lastname: Iwamoto
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Kubo
authors.forename: E
authors.initials: E
authors.lastname: Ishihara
authors.forename: Y
authors.initials: Y
authors.lastname: Komatsu
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: T
authors.initials: T
authors.lastname: Ishida
authors.forename: K
authors.initials: K
authors.lastname: Tanigawa
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy*; D004195:Disease Models, Animal; D005960:Glucosides / Q000737:chemistry / Q000627:therapeutic use; D006946:Hyperinsulinism / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000737:chemistry / Q000627:therapeutic use*; D007328:Insulin / Q000032:analysis; D007333:Insulin Resistance; D019684:Magnoliopsida / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts; D014966:Xanthenes / Q000737:chemistry / Q000627:therapeutic use*; D044004:Xanthones
chemical_list: D001786:Blood Glucose; D005960:Glucosides; D007004:Hypoglycemic Agents; D007328:Insulin; D010936:Plant Extracts; D014966:Xanthenes; D044004:Xanthones; C013592:mangiferin