Back in the water: the return of the inositol phosphates.
Following the discovery of inositol-1,4,5-trisphosphate as a second messenger, many other inositol phosphates were discovered in quick succession, with some understanding of their synthesis pathways and a few guesses at their possible functions. But then it all seemed to go comparatively quiet, with an explosion of interest in the inositol lipids. Now the water-soluble phase is once again becoming a focus of interest. Old and new data point to a new vista of inositol phosphates, with functions in many diverse aspects of cell biology, such as ion-channel physiology, membrane dynamics and nuclear signalling.
Irvine
R F
RF
Department of Pharmacology, Tennis Court Road, Cambridge CB2 1QJ, UK. rfi20@cam.ac.uk
Schell
M J
MJ
D000818:Animals; D005057:Eukaryotic Cells / Q000378:metabolism*; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D014867:Water / Q000378:metabolism*
D007295:Inositol Phosphates; D014867:Water