Geographical north-south decline in DNASE1*2 in Japanese populations.
Allele frequencies for human deoxyribonuclease I (DNase I) phenotypes were determined using blood samples from about 2000 Japanese subjects living in nine prefectures, and compared with one another. DNase I phenotyping was performed principally using isoelectric focusing electrophoresis and activity staining. The DNase I system was shown to have enhanced potential for anthropologic, genetic, and clinical studies of Japanese populations. DNase I phenotypes were analyzed to evaluate the degree of genetic variation at the DNASE1 locus. Our examination of DNase I types revealed a decreasing north-to-south gradient in the DNASE1 allele.
Takeshita
H
H
Department of Legal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Yasuda
T
T
Nakashima
Y
Y
Mogi
K
K
Kishi
K
K
Shiono
H
H
Sagisaka
K
K
Yuasa
I
I
Nishimukai
H
H
Kimura
H
H
D016022:Case-Control Studies; D003850:Deoxyribonuclease I / Q000235:genetics*; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D007564:Japan; D010641:Phenotype; D012111:Residence Characteristics
D003850:Deoxyribonuclease I