title: Cutting edge: FISP (IL-4-induced secreted protein), a novel cytokine-like molecule secreted by Th2 cells.
abstract: Th cell subsets, namely Th1 and Th2 cells, play an important role in mounting an immune response against invading pathogens. Several genes are selectively up-regulated during differentiation and effector phases of Th subsets. In this study, we report the identification of a novel cytokine-like molecule designated FISP (IL-4-induced secreted protein), which is selectively expressed and secreted by Th2 cells. Detectable levels of FISP are observed only 3 days after initiation of Th2 differentiation. Expression of FISP in developing Th cells requires at least two signals: TCR signaling involving protein kinase C activation and STAT6-dependent IL-4R signaling.
authors.affiliation: Tularik Inc., Two Corporate Drive, South San Francisco, CA 94080, USA.
authors.forename: G
authors.initials: G
authors.lastname: Schaefer
authors.forename: C
authors.initials: C
authors.lastname: Venkataraman
authors.forename: U
authors.initials: U
authors.lastname: Schindler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry; D002454:Cell Differentiation / Q000276:immunology; D002460:Cell Line; D002999:Clone Cells; D016207:Cytokines / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D005260:Female; D016147:Genes, Tumor Suppressor; D006133:Growth Substances / Q000737:chemistry; D006801:Humans; D015847:Interleukin-4 / Q000502:physiology*; D007378:Interleukins; D008213:Lymphocyte Activation; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D013154:Spleen / Q000166:cytology; D018417:Th1 Cells / Q000378:metabolism; D018418:Th2 Cells / Q000166:cytology / Q000378:metabolism*; D014158:Transcription, Genetic / Q000276:immunology; D000099180:Interleukin-24
chemical_list: D002352:Carrier Proteins; D016207:Cytokines; D006133:Growth Substances; D015847:Interleukin-4; D007378:Interleukins; D011506:Proteins; D011948:Receptors, Antigen, T-Cell; D000099180:Interleukin-24; C413022:IL24 protein, rat; C431904:Il24 protein, mouse