title: Gordon Memorial Lecture. Newcastle disease.
abstract: 1. In this paper several historical and contemporary aspects of Newcastle disease (ND) are reviewed, with particular reference to the greater understanding which modern techniques have allowed. 2. Virulent ND viruses were generally thought to have emerged in 1926 as a result of transfer from a wild bird host reservoir but there is evidence that the virulent virus may have existed in poultry before 1926. Recent findings suggest that the virulent virus may emerge in poultry as a result of mutations in viruses of low virulence. 3. The history of ND in Great Britain reflects the four known panzootics that have occurred and serves as a model for the impact this disease may have on poultry populations. 4. Attempts to control and eradicate ND are not as straightforward as it may appear; in particular vaccination, while preventing deaths and disease, on challenge may not prevent virus replication and could therefore lead to the virulent virus becoming endemic. 5. Village chickens are extremely important assets in most developing countries, representing a significant source of protein in the form of eggs and meat but endemic ND can cause mortality of up to 60% in village chickens.
authors.affiliation: dalexander.vla@gtnet.gov.uk
authors.forename: D J
authors.initials: DJ
authors.lastname: Alexander
mesh_terms: D000818:Animals; D001717:Birds; D002645:Chickens; D010856:Columbidae; D021821:Communicable Diseases, Emerging / Q000453:epidemiology / Q000662:veterinary / Q000821:virology; D004196:Disease Outbreaks / Q000662:veterinary; D009154:Mutation; D009521:Newcastle Disease / Q000453:epidemiology / Q000473:pathology / Q000821:virology*; D009522:Newcastle disease virus / Q000302:isolation & purification / Q000472:pathogenicity*; D015995:Prevalence; D006113:United Kingdom / Q000453:epidemiology; D014611:Vaccination / Q000662:veterinary; D014774:Virulence; D014779:Virus Replication