Cimetidine does not influence TIL in breast cancer.
Cimetidine is known to have immunomodulatory effects and this study aimed to examine the effect of pre-operative cimetidine treatment on lymphocytic infiltration in n = 72 women with breast cancer randomised to 400 mg bd or placebo for five days presurgery. A combined index was devised by adding infiltrating lymphocyte percentage and lymphoid score. There were no significant differences in circumferential infiltrate and lymphoid follicles in cimetidine treated patients and control patients with breast cancer.
Dwerryhouse
S J
SJ
Department of Surgery, The University of New South Wales, The St. George Hospital, Sydney, Australia.
Soon Lee
C
C
King
J
J
Magarey
C
C
Schwartz
P
P
Morris
D L
DL
D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology* / Q000601:surgery; D002927:Cimetidine / Q000627:therapeutic use*; D005260:Female; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D016246:Lymphocytes, Tumor-Infiltrating / Q000187:drug effects*; D008221:Lymphoid Tissue / Q000187:drug effects / Q000473:pathology; D011300:Preoperative Care; D012016:Reference Values; D016037:Single-Blind Method
D006635:Histamine H2 Antagonists; D002927:Cimetidine