Antiviral activity of fattiviracin FV-8 against human immunodeficiency virus type 1 (HIV-1).
A novel antiviral agent, fattiviracin FV-8, purified from the culture broth of Streptomyces microflavus strain No. 2445, showed potent antiviral activities against human immunodeficiency virus type 1 (HIV-1), herpes simplex virus type 1 (HSV-1), varicella-zoster virus (VZV), and influenza A and B viruses. The action mechanism of fattiviracin FV-8 against HIV-1 was examined. As a result, the agent was thought to act on HIV-1 particles directly without lysis of the particles, and it affords the inhibition of viral entry into the host cells.
Habib
E S
ES
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan.
Yokomizo
K
K
Nagao
K
K
Harada
S
S
Uyeda
M
M
D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002522:Chlorocebus aethiops; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D006017:Glycolipids / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D018259:Herpesvirus 1, Human / Q000187:drug effects; D014645:Herpesvirus 3, Human / Q000187:drug effects; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D009981:Influenza B virus / Q000187:drug effects; D013302:Streptomyces; D014709:Vero Cells
D019380:Anti-HIV Agents; D000998:Antiviral Agents; D005231:Fatty Acids, Unsaturated; D006017:Glycolipids; C437408:fattiviracin FV-8; D005947:Glucose