Fibromyalgia developed after administration of gonadotrophin-releasing hormone analogue.
We report the case of a woman treated with a gonadotrophin-releasing hormone analogue for endometriosis who developed typical clinical features of fibromyalgia, with widespread musculoskeletal pain, sleep difficulties, neuropsychological complaints and tender points on clininal examination. The gonadotrophin-releasing hormone analogue treatment probably induced disturbances in the neuroendocrine system and the secretion of neurotransmitters, and may be suspected to be the cause of this case of fibromyalgia.
Toussirot
E
E
University Hospital Jean Minjoz, Besançon, France. eric.toussirot@ufc-chu.univ-fcomte.fr
Wendling
D
D
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000009:adverse effects*; D004715:Endometriosis / Q000150:complications* / Q000188:drug therapy; D005260:Female; D005356:Fibromyalgia / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D016729:Leuprolide / Q000009:adverse effects*
D018931:Antineoplastic Agents, Hormonal; D016729:Leuprolide