title: Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate.
abstract: Pentavalent antimony is still the drug of choice in the treatment of visceral leishmaniasis. Pantavalent antimony can cause a wide range of adverse effects, the most serious of which are cardiotoxicity and hepatotoxicity. Acute pancreatitis is a rarely reported adverse effect. An infant who developed pancreatitis during meglumine antimoniate treatment for visceral leishmaniasis and who was successfully treated with a combination of allopurinol and ketoconazole is reported.
authors.affiliation: Dr. Sami Ulus Children's Hospital, Ankara, Turkey. nkuyucu@yahoo.com
authors.forename: N
authors.initials: N
authors.lastname: Kuyucu
authors.forename: C
authors.initials: C
authors.lastname: Kara
authors.forename: A
authors.initials: A
authors.lastname: Bakirtaç
authors.forename: T
authors.initials: T
authors.lastname: Teziç
mesh_terms: D000208:Acute Disease; D000493:Allopurinol / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002675:Child, Preschool; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D007898:Leishmaniasis, Visceral / Q000188:drug therapy*; D008297:Male; D008536:Meglumine / Q000009:adverse effects* / Q000627:therapeutic use; D000077485:Meglumine Antimoniate; D009942:Organometallic Compounds / Q000009:adverse effects* / Q000627:therapeutic use; D010195:Pancreatitis / Q000139:chemically induced*
chemical_list: D000981:Antiprotozoal Agents; D009942:Organometallic Compounds; D000493:Allopurinol; D008536:Meglumine; D000077485:Meglumine Antimoniate; D007654:Ketoconazole