title: Developmental analysis of ceruloplasmin gene and liver formation in zebrafish.
abstract: Formation of the liver in zebrafish has been analyzed during normal embryogenesis using ceruloplasmin (Cp) as a specific marker. The asymmetric expression of Cp has been detected in dorsal endoderm at 16 hpf and later in the early hepatic cells in the yolk sac. The liver primordium can be detected after 32 hpf. In oep-/- mutant, which lacks dorsal endoderm, the liver fails to form. In the notochordless flh-/- mutant, the asymmetry of the liver has been lost. Therefore the notochord, dorsal endoderm and endoderm of the yolk sac play a role in liver formation in zebrafish.
authors.affiliation: The Institute of Molecular Agrobiology, The National University of Singapore, 1 Research Link, Singapore 117604, Singapore.
authors.forename: S
authors.initials: S
authors.lastname: Korzh
authors.forename: A
authors.initials: A
authors.lastname: Emelyanov
authors.forename: V
authors.initials: V
authors.lastname: Korzh
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002570:Ceruloplasmin / Q000096:biosynthesis* / Q000235:genetics*; D004707:Endoderm / Q000378:metabolism; D005819:Genetic Markers; D017403:In Situ Hybridization; D008099:Liver / Q000196:embryology* / Q000378:metabolism*; D008954:Models, Biological; D009154:Mutation; D013997:Time Factors; D014018:Tissue Distribution; D015017:Yolk Sac / Q000378:metabolism; D015027:Zebrafish
chemical_list: D005819:Genetic Markers; D002570:Ceruloplasmin