title: Increased familial risk of cluster headache.
abstract: The authors studied the occurrence of cluster headache in the families of 220 Italian patients with cluster headache. A positive family history was found in 20% (44/220) of the families. Compared with the general population, first-degree relatives had a 39-fold significantly increased risk of cluster headache. Second-degree relatives had an eightfold significantly increased risk. The increased familial risk strongly supports the hypothesis that cluster headache has a genetic component in some families.
authors.affiliation: Carlo Besta National Neurological Institute, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Leone
authors.forename: M B
authors.initials: MB
authors.lastname: Russell
authors.forename: A
authors.initials: A
authors.lastname: Rigamonti
authors.forename: A
authors.initials: A
authors.lastname: Attanasio
authors.forename: L
authors.initials: L
authors.lastname: Grazzi
authors.forename: D
authors.initials: D
authors.lastname: D'Amico
authors.forename: S
authors.initials: S
authors.lastname: Usai
authors.forename: G
authors.initials: G
authors.lastname: Bussone
mesh_terms: D000328:Adult; D000367:Age Factors; D003027:Cluster Headache / Q000453:epidemiology* / Q000209:etiology / Q000235:genetics*; D005260:Female; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D012737:Sex Factors