title: Timing of leukocyte filtration during cardiopulmonary bypass.
abstract: The effects of leukocyte filtration on the outcome of cardiac surgery with cardiopulmonary bypass (CPB) have been shown by numerous investigators. In the majority of cases a leukocyte filter is placed in the arterial line instead of a standard arterial line filter and used throughout CPB. However, protocols to optimize onset and duration of leukocyte filtration have not been sufficiently evaluated to date. In this paper, current efforts to improve such protocols are demonstrated and discussed. These efforts are based on studies of leukocyte pathogenicity during cardiac surgery. A first study (double-blind randomized) was performed in routine coronary artery bypass graft (CABG) patients to evaluate whether short-term leukocyte filtration during reperfusion by release of the aortic crossclamp would reduce reperfusion-associated myocardial damage. Further data compare the efficacy of three different filtration concepts to reduce CPB- and/or reperfusion-associated leukocyte pathogenicity. Clinical endpoints, standard laboratory variables and functional in vitro assays are provided and discussed.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, JW Goethe University, Frankfurt, Germany. matheis.gbr@gmx.de
authors.forename: G
authors.initials: G
authors.lastname: Matheis
authors.forename: M
authors.initials: M
authors.lastname: Scholz
authors.forename: A
authors.initials: A
authors.lastname: Simon
authors.forename: D
authors.initials: D
authors.lastname: Henrich
authors.forename: G
authors.initials: G
authors.lastname: Wimmer-Greinecker
authors.forename: A
authors.initials: A
authors.lastname: Moritz
mesh_terms: D002315:Cardiopulmonary Bypass / Q000379:methods* / Q000592:standards; D002986:Clinical Trials as Topic; D005374:Filtration / Q000379:methods; D006801:Humans; D007937:Leukapheresis / Q000592:standards*; D009504:Neutrophils / Q000378:metabolism / Q000473:pathology; D013997:Time Factors