title: The G protein beta3 subunit 825T allele is a genetic marker for enhanced T cell response.
abstract: The G protein beta3 subunit (GNB3) 825T allele is predictive of enhanced Gi protein activation. Studying the influence of C825T allele status on cellular in vitro immune responses towards recall antigens and interleukin-2 stimulation we observed a 2-4-fold, significantly increased proliferation in homozygous 825T (TT) vs. C825 allele (CC) carriers. Furthermore, lymphocyte chemotaxis and CD4(+) T cell counts of individuals with TT+TC genotypes were significantly enhanced compared to the CC genotype. In summary, it appears that C825T allele status is highly predictive of immunocompetence and could be a candidate gene in disorders associated with inadequate immune response.
authors.affiliation: Institut für Immunologie, Universitätsklinikum, 45122 Essen, Germany. immunologie@uni-essen.de
authors.forename: M
authors.initials: M
authors.lastname: Lindemann
authors.forename: S
authors.initials: S
authors.lastname: Virchow
authors.forename: F
authors.initials: F
authors.lastname: Ramann
authors.forename: V
authors.initials: V
authors.lastname: Barsegian
authors.forename: E
authors.initials: E
authors.lastname: Kreuzfelder
authors.forename: W
authors.initials: W
authors.lastname: Siffert
authors.forename: N
authors.initials: N
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Grosse-Wilde
mesh_terms: D000483:Alleles; D000941:Antigens / Q000494:pharmacology; D015703:Antigens, CD / Q000378:metabolism; D018791:CD4 Lymphocyte Count; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D002633:Chemotaxis / Q000187:drug effects; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics*; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D007121:Immunocompetence / Q000235:genetics*; D016130:Immunophenotyping; D007376:Interleukin-2 / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000235:genetics*; D016131:Lymphocyte Subsets / Q000166:cytology / Q000378:metabolism; D008297:Male; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology*
chemical_list: D000941:Antigens; D015703:Antigens, CD; D005819:Genetic Markers; D007376:Interleukin-2; D020962:Heterotrimeric GTP-Binding Proteins