Random total antiepileptic drug levels and seizure control during pregnancy.
OBJECTIVE
To study the correlation of randomly-tested total antiepileptic plasma levels and seizure control in a retrospectively collected group of pregnant epileptic Saudi women.


METHODS
The medical records of 30 Saudi epileptic female patients were reviewed during their subsequent pregnancies (total of 50). The type of antiepileptic drugs used during each pregnancy, the dose of each drug and the corresponding total plasma levels were noted. Antiepileptic drugs assay were carried out randomly during pregnancy either by TDX or a sensitive high performance liquid chromatography method.


RESULTS
A total of 50 pregnancies were studied. The most common seizure type in these women was complex partial seizure followed by primary generalized epilepsy, myoclonic seizures and of least occurrence was the simple partial seizure with secondary generalization. All patients were received antiepileptic drugs, including either carbamazepine, phenytoin, valporic acid, phenobarbitone or clonazepam. In a total of 24 pregnancies (48%), the serum levels of antiepileptic drugs were subtherapeutic during the first trimester. Recurrent seizures occurred in a total of 20 pregnancies (40%) especially in the 3rd trimester.


CONCLUSIONS
It is concluded that subtherapeutic serum levels of antiepileptic drugs correlated highly with the increased frequency of seizure in these pregnant women. Monitoring of state of seizure control in epileptic pregnant women should be made regularly during the course of their pregnancies.
Al-Bunyan
M A
MA
Division of Neurology, Department of Medicine, King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia. mbunyan@ksu.edu.sa
D000328:Adult; D000927:Anticonvulsants / Q000097:blood* / Q000627:therapeutic use*; D002851:Chromatography, High Pressure Liquid; D016903:Drug Monitoring / Q000379:methods; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008423:Maternal Age; D008875:Middle Aged; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000188:drug therapy* / Q000517:prevention & control*; D011295:Prenatal Care / Q000379:methods; D012008:Recurrence; D012189:Retrospective Studies; D012307:Risk Factors; D012529:Saudi Arabia
D000927:Anticonvulsants