title: Effect of miracidial dose on adoptively transferred resistance to Schistosoma mansoni in the snail intermediate host, Biomphalaria glabrata.
abstract: Adoptively transferred resistance to Schistosoma mansoni in the snail intermediate host Biomphalaria glabrata was measured as a function of miracidial challenge dose. Schistosome-susceptible snails implanted with the amebocyte-producing organ (APO) from resistant donors showed 29 and 39% prevalences of infection after challenge with 5 and 10 miracidia, respectively, but 68-83% prevalences when exposed to 25-200 miracidia. Prevalences in control (untampered) susceptible snails ranged from 97 to 100% at the different miracidial doses. Higher infection prevalences at elevated doses suggest that a range of transferred resistance occurs and possibly that low levels of APO-derived plasma factors or hemocytes in some recipients can be overwhelmed by larger numbers of parasites.
authors.affiliation: Biology Department, University of the Incarnate Word, San Antonio, Texas 78209, USA.
authors.forename: R E
authors.initials: RE
authors.lastname: Vasquez
authors.forename: J T
authors.initials: JT
authors.lastname: Sullivan
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D001700:Biomphalaria / Q000276:immunology* / Q000469:parasitology; D007113:Immunity, Innate; D012550:Schistosoma mansoni / Q000472:pathogenicity*