Cyclic guanine monophosphate (cGMP) an intracellular mediator of cavernosal smooth muscle relaxation following penile vascular surgery.
BACKGROUND
We describe a new surgical method for treatment of male impotence. This procedure allows preservation of erectile tissues and avoids the need for implantable devices. It was demonstrated, that after this procedure sustained and reproducible erections were feasible. The role of cyclic guanine monophosphate (cGMP) in generation of erection following this procedure was studied.


METHODS
Concentration of cGMP in erectile tissues was studied in the chronic canine experimental model. cGMP measurements were obtained using enzymeimmunoassay method.


RESULTS
It was detected that the process of erection was accompanied with increased concentration of cGMP in the involved erectile structures (from 39.59 +/- 8.95 and 39.39 +/- 8.54 pm/g to 78.67 +/- 24.05 and 81.62 +/- 18.80 pm/g respectively with p = 0.0001). Concentration of cGMP did not change in the control (from 41.14 +/- 5.38 to 39.26 +/- 7.59 pm/g with p = 0.4568).


CONCLUSIONS
It can be concluded, that proposed new surgical procedure causes erection not by simple distention of erectile tissue sinuses by arterial blood. Arterial blood inflow is accompanied by activation of intracellular mechanisms responsible for smooth muscle relaxation in erectile tissues. Normal values of cGMP concentration in canine erectile tissues are also reported.
Godziachvili
V
V
Department of Surgery, North Oakland Medical Centers, Pontiac, MI 48341, USA.
Saba
A
A
Chahin
F
F
Godziashvili
Z
Z
Libcke
J
J
Silva
Y J
YJ
D000818:Animals; D006152:Cyclic GMP / Q000502:physiology*; D004285:Dogs; D007425:Intracellular Membranes / Q000378:metabolism*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000503:physiopathology*; D009994:Osmolar Concentration; D010410:Penile Erection / Q000502:physiology; D010413:Penis / Q000098:blood supply*; D011184:Postoperative Period; D012016:Reference Values; D014656:Vascular Surgical Procedures; D014664:Vasodilation / Q000502:physiology*
D006152:Cyclic GMP