A case of renal involvement in persistent immune activation caused by chlamydial salpingitis.
A 24-year-old woman presented with renal insufficiency, macrohematuria, and mild urinary protein. Polyclonal hypergamma-globulinemia, thrombocytosis, increased concentration of serum, and urinary interleukin (IL)-6 all indicated persistent immune activation caused by a Chlamydia trachomatis infection of the fallopian tube. Gynecological treatment with levofloxacin was effective both for the renal symptoms and other immunological parameters. First and second renal biopsy specimens showed an immune-complex glomerulopathy with extensive interstitial infiltration of many types of inflammatory cells, including plasma cells. Thus, we conclude that chlamydial salpingitis must be considered as one causative disease factor for renal involvement by means of its persistent immune activation effects.
Ohsawa
I
I
Department of Internal Medicine II, Nihon University School of Medicine, Oyaguchi-kamimachi 30-1, Itabashi-ku, Tokyo 173-8610, Japan. iohsawa@med.nihon-u.ac.jp
Ohi
H
H
Endo
M
M
Fujita
T
T
Hidaka
M
M
Satomura
A
A
Yamaguchi
Y
Y
D000328:Adult; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D002690:Chlamydia Infections / Q000150:complications / Q000473:pathology*; D002692:Chlamydia trachomatis; D005260:Female; D005922:Glomerulonephritis, IGA / Q000209:etiology; D006801:Humans; D015850:Interleukin-6 / Q000502:physiology; D007668:Kidney / Q000473:pathology*; D012488:Salpingitis / Q000150:complications / Q000473:pathology*
D000936:Antigen-Antibody Complex; D015850:Interleukin-6