title: Prooxidant-antioxidant state after administration of lipopolysaccharide during correction of the L-arginine-NO system and affinity of hemoglobin for oxygen.
abstract: We studied the effect of correction of the L-arginine-NO system on the fever reaction and prooxidant-antioxidant state in rats with increased hemoglobin oxygen affinity caused by sodium cyanate after intramuscular injection of lipopolysaccharide. The imbalance between parameters of the prooxidant-antioxidant state in rats with increased hemoglobin oxygen affinity was least pronounced after lipopolysaccharide administration. Correction of the L-arginine-NO system in rats with increased hemoglobin oxygen affinity had no effect on the contents of Schiff bases and antioxidants after lipopolysaccharide administration.
authors.affiliation: Department of Normal Physiology, Grodno Medical University, Belarus. zinchuk@grsmi.unibel.by
authors.forename: V V
authors.initials: VV
authors.lastname: Zinchuk
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001120:Arginine / Q000378:metabolism; D003485:Cyanates / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005334:Fever; D006454:Hemoglobins / Q000378:metabolism*; D015227:Lipid Peroxidation; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D005996:Nitroglycerin / Q000494:pharmacology; D010084:Oxidation-Reduction; D010100:Oxygen / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000378:metabolism; D051381:Rats; D012481:Salmonella Infections, Animal / Q000378:metabolism; D014665:Vasodilator Agents / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D003485:Cyanates; D004791:Enzyme Inhibitors; D006454:Hemoglobins; D008070:Lipopolysaccharides; D010108:Oxyhemoglobins; D014665:Vasodilator Agents; D009569:Nitric Oxide; C009281:sodium cyanate; D001120:Arginine; D005996:Nitroglycerin; D010100:Oxygen; D019331:NG-Nitroarginine Methyl Ester