[Comparison of HLA class I and DR class II antigen frequency in Polish patients, in relation to different stages of the disease].
The aim of this study was to analyze the association between HLA class I and class II DR frequency in the different stages of sarcoidosis in Polish population. 88 patients and 30 healthy controls have been typed. Patients were divided into three groups depending on radiological findings. In the first group were 28 cases presenting the regression of the disease. In the second were 33 patients in stable stage II or III and in the third group 27 patients with pulmonary fibrosis (stage IV). The typing was performed by NIH method using commercial sera. There were no statistically significant differences between studied group in HLA-A class I. The frequency of HLA B-18 was statistically more frequent in patients with sarcoidosis compared to healthy controls. HLA-DR1 was not present in third group of patients and the difference was significant compared to healthy controls.
Puścińska
E
E
Kliniki Chorób Płuc, Instytutu Gruźlicy i Chorób Płuc, Warszawie.
Goljan
A
A
Zych
D
D
Pawlicka
L
L
Kowalski
J
J
Zieliński
J
J
D000328:Adult; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015235:HLA-B Antigens / Q000032:analysis / Q000235:genetics; D059911:HLA-B18 Antigen; D015798:HLA-DR1 Antigen / Q000032:analysis / Q000235:genetics; D015802:HLA-DR2 Antigen / Q000032:analysis* / Q000235:genetics; D006801:Humans; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging / Q000276:immunology; D011859:Radiography; D012129:Respiratory Function Tests; D012507:Sarcoidosis / Q000145:classification / Q000000981:diagnostic imaging / Q000276:immunology*; D012703:Serotyping
D006680:HLA Antigens; D015235:HLA-B Antigens; D059911:HLA-B18 Antigen; D015798:HLA-DR1 Antigen; D015802:HLA-DR2 Antigen