[Treatment of erosive gastropathy caused by nonsteroidal anti-inflammatory agents using low doses of antacids].
In an open clinical, endoscopy controlled study involving 31 patients with erosive NSAIDs-induced gastropathy without Helicobacter pylori infection, the effect of low dose of antacids (120 mmol/l) with aluminium oxide and magnesium oxide (Maalox) administered for 4 weeks was followed. The administration of NSAIDs was not interrupted during the time of treatment. Healing rate of the gastric erosions after four weeks reached 65% (20/31) and endoscopic score in the gastric mucosa proved significant improvement (0.97 +/- 0.49 compared to 0.07 +/- 0.25, p < 0.01). Our results suggest efficacy of low dose antacids containing aluminium in the treatment of NSAIDs-induced gastric erosions.
Rybár
I
I
Subkatedra reumatológie Slovenskej postgraduálnej akadémie medicíny, Piest'any.
Rovenský
J
J
Orlovská
M
M
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000863:Antacids / Q000008:administration & dosage*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008276:Magnesium Hydroxide / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000188:drug therapy
D000863:Antacids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D004338:Drug Combinations; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D008276:Magnesium Hydroxide