title: Immunoregulatory role of secreted glycoprotein G from respiratory syncytial virus.
abstract: The secretory glycoprotein (Gs) of respiratory syncytial virus (RSV) was enriched and investigated for its effects on T cells specific for RSV and unrelated antigens. Gs exhibited a dose dependent suppression of lymphoproliferative responses in peripheral blood mononuclear cells (PBMCs), specific for mycobacterial lysates or tetanus toxoid. However, Gs did not inhibit live RSV specific T cell responses. These results suggest that Gs may suppress immune response to unrelated antigens, but should not interfere with the overall development of RSV specific immunity.
authors.affiliation: Division of Infectious Diseases and Immunology, Saint Louis University, 3635 Vista Avenue, St. Louis, MO 63110, USA. rayr@slu.edu
authors.forename: R
authors.initials: R
authors.lastname: Ray
authors.forename: D F
authors.initials: DF
authors.lastname: Hoft
authors.forename: K
authors.initials: K
authors.lastname: Meyer
authors.forename: R
authors.initials: R
authors.lastname: Brown
authors.forename: L M
authors.initials: LM
authors.lastname: Lagging
authors.forename: R B
authors.initials: RB
authors.lastname: Belshe
mesh_terms: D000328:Adult; D000818:Animals; D006801:Humans; D008213:Lymphocyte Activation; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000276:immunology* / Q000378:metabolism*
chemical_list: D014764:Viral Proteins