Nonopsonic phagocytosis of Pseudomonas aeruginoas: insights from an infant with leukocyte adhesion deficiency.
Children with leukocyte adhesion deficiency type I are at risk for overwhelming infection because their neutrophils lack surface beta 2 integrins (CD18/CD11) that normally interact with endothelial cell adhesion molecules and mediate migration to sites of bacterial invasion. In vitro studies of phagocytic cells from an infant with leukocyte adhesion deficiency type I demonstrated that complement receptor 3 (CD18/CD11b) mediates nonopsonic phagocytosis of some Pseudomonas aeruginosa strains and might play a control role in the control of Pseudomonas infections at sites where there are low levels of opsonins.
Pollard
A J
AJ
Department of Pediatrics, Children's and Women's Health Centre of British Columbia, BC Research Institute for Children's and Women's Health, Vancouver, Canada. ajpollard@compuserve.com
Heale
J P
JP
Tsang
A
A
Massing
B
B
Speert
D P
DP
D018821:CD18 Antigens; D006801:Humans; D007231:Infant, Newborn; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000150:complications* / Q000276:immunology; D016177:Macrophage-1 Antigen; D010587:Phagocytosis / Q000276:immunology*; D011552:Pseudomonas Infections / Q000150:complications* / Q000276:immunology*; D011550:Pseudomonas aeruginosa
D018821:CD18 Antigens; D016177:Macrophage-1 Antigen