[Acral myxoinflammatory fibroblastic sarcoma. Six cases of a tumor entity].
Acral myxoinflammatory fibroblastic sarcomas are low-grade sarcomas of the distal extremities, first described by Meis-Kindblom and Kindblom in 1998. In our series of six cases this sarcoma occurred in four men and two women aged 22-60 years (mean 42.8). The tumors measured 1-4 cm (mean 2.4) and were localized in the foot (two cases), finger (two), wrist (one), and upper arm (one). The patients had a short history of a painless mass (mean duration 3 months). The tumors were poorly circumscribed, and infiltrated the subcutaneous fat and in one case each also the dermis and musculature. Histological features of the tumors were a multinodular configuration with infiltrative margins, myxoid and fibrotic zones with hyalinized areas, moderately pleomorphic cells with large cells showing a prominent nucleolus and an inflammatory infiltrate consisting of lymphocytes and histiocytes. Two months after excision the tumor recurred locally in two cases; no metastases were observed. Differential diagnosis is especially necessary from inflammatory pseudotumors and more aggressive sarcomas.
Ebhardt
H
H
Institut für Pathologie, Friedrich-Schiller-Universität, Ziegelmühlenweg 1, 07740 Jena. ebhardt@bach.med.uni-jena.de
Kosmehl
H
H
Katenkamp
D
D
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007249:Inflammation; D016246:Lymphocytes, Tumor-Infiltrating / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000145:classification* / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D013997:Time Factors; D016896:Treatment Outcome