title: Association between the SDF1-3'A allele and high levels of CD34(+) progenitor cells mobilized into peripheral blood in humans.
abstract: Some patients unexpectedly fail to mobilize sufficient numbers of haematopoietic progenitor cells (HPCs) into the peripheral blood for autologous transplantation. Considering the important role of the chemokine stromal cell-derived factor 1 (SDF-1) in HPC homing, we investigated a possible relationship between SDF1 gene polymorphism and HPC mobilization capacity in 63 patients with malignancy. Some 67% of the good mobilizers (> or = 50 CD34(+) cells/microl) and only 36% of the intermediate/poor mobilizers were SDF1-3'A allele carriers (P = 0.032). In multivariate analysis, the presence of the SDF1-3'A allele was the only factor predictive of good CD34(+) cell mobilization (P = 0.025). This is the first report showing the involvement of genetic factors for HPC mobilization in humans and suggests a significant role for SDF-1 in this process.
authors.affiliation: UPRES-EA Haematopoietic Cells, Haemostasis and Transplantation, University of Tours, France.
authors.forename: L
authors.initials: L
authors.lastname: Benboubker
authors.forename: H
authors.initials: H
authors.lastname: Watier
authors.forename: A
authors.initials: A
authors.lastname: Carion
authors.forename: M T
authors.initials: MT
authors.lastname: Georget
authors.forename: I
authors.initials: I
authors.lastname: Desbois
authors.forename: P
authors.initials: P
authors.lastname: Colombat
authors.forename: P
authors.initials: P
authors.lastname: Bardos
authors.forename: C
authors.initials: C
authors.lastname: Binet
authors.forename: J
authors.initials: J
authors.lastname: Domenech
mesh_terms: D000328:Adult; D000483:Alleles; D018952:Antigens, CD34; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics*; D005260:Female; D019337:Hematologic Neoplasms / Q000235:genetics* / Q000276:immunology / Q000601:surgery; D019650:Hematopoietic Stem Cell Mobilization; D018380:Hematopoietic Stem Cell Transplantation; D006689:Hodgkin Disease / Q000235:genetics / Q000276:immunology / Q000601:surgery; D006801:Humans; D008223:Lymphoma / Q000235:genetics / Q000276:immunology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics / Q000276:immunology / Q000601:surgery; D015999:Multivariate Analysis; D011110:Polymorphism, Genetic; D013234:Stem Cells / Q000276:immunology*
chemical_list: D018952:Antigens, CD34; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC