title: Radioisotope scintigraphy in the diagnosis of hepatic hydrothorax.
abstract: BACKGROUND
  Pleural effusion in cirrhotic patients (hepatic hydrothorax) may result from migration of ascitic fluid across defects in the diaphragm. Biochemical analysis of ascitic and pleural fluid provides only indirect information about the nature and origin of the effusion. The present study was performed in order to demonstrate the presence/absence of peritoneo-pleural communication by radioisotope imaging.
  
  
  METHODS
  Ten patients with cirrhotic ascites and pleural effusion were studied with 99mTc sulfur colloid scintigraphy to look for movement of the radiotracer from the peritoneal to the pleural cavity. Serum-ascitic albumin gradient (SAAG) and serum-pleural fluid albumin gradient (SPAG) values were determined in eight patients to examine the nature of the ascitic and pleural fluids.
  
  
  RESULTS
  Transdiaphragmatic movement of ascitic fluid into the pleural space was demonstrated (generally within 2 h of intraperitoneal injection of the radiotracer) in eight of 10 patients; six on the right side, one on the left and one bilaterally. Two patients in whom pleural fluid was transudative on SPAG values were negative for peritoneo-pleural communications.
  
  
  CONCLUSIONS
  Radionuclide scintigraphy is a simple, safe and relatively non-invasive method to confirm passage of ascitic fluid across the diaphragm.
authors.affiliation: Department of Nuclear Medicine, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
authors.forename: A
authors.initials: A
authors.lastname: Bhattacharya
authors.forename: B R
authors.initials: BR
authors.lastname: Mittal
authors.forename: T
authors.initials: T
authors.lastname: Biswas
authors.forename: R K
authors.initials: RK
authors.lastname: Dhiman
authors.forename: B
authors.initials: B
authors.lastname: Singh
authors.forename: S K
authors.initials: SK
authors.lastname: Jindal
authors.forename: Y
authors.initials: Y
authors.lastname: Chawla
mesh_terms: D000328:Adult; D000368:Aged; D001201:Ascites / Q000209:etiology; D003964:Diaphragm / Q000000981:diagnostic imaging / Q000378:metabolism; D005355:Fibrosis / Q000150:complications*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010537:Peritoneum / Q000000981:diagnostic imaging / Q000378:metabolism; D010994:Pleura / Q000000981:diagnostic imaging / Q000378:metabolism; D010996:Pleural Effusion / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000378:metabolism; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid
chemical_list: D013671:Technetium Tc 99m Sulfur Colloid