Effect of Ukrain on human liver alcohol dehydrogenase activity in vitro.
In the present study it was found that Ukrain inhibits the ethanol oxidation process catalyzed by human alcohol dehydrogenase (ADH). Ukrain at a concentration of 10(-6), 2.5 x 10(-6), and 5.0 x 10(-6) M decreased liver ADH activity in the presence ethanol (approximately 8.41%, 13.28%, 16.69%, respectively) as well as in the presence of methanol (approximately 13.29%, 19.07% and 42.20%, respectively).
Jagiełło-Wójtowicz
E
E
Department of Toxicology, University Medical School, Chodki 7, 20-093 Lublin, Poland.
Dudka
J
J
Dawidek-Pietryka
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K
D000328:Adult; D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000470:Alkaloids / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001600:Berberine Alkaloids; D000431:Ethanol / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D000432:Methanol / Q000494:pharmacology; D009243:NAD / Q000378:metabolism; D010617:Phenanthridines
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D001600:Berberine Alkaloids; D010617:Phenanthridines; D009243:NAD; D000431:Ethanol; C060921:ukrain; D000426:Alcohol Dehydrogenase; D000432:Methanol