Incidence of familial Mediterranean fever (FMF) mutations among children of Mediterranean extraction with functional abdominal pain.
Of 59 Sephardic Jewish and Arab children in whom functional abdominal pain was diagnosed, we found that 20% were homozygote for the familial Mediterranean fever gene. Inclusion of genetic screening for familial Mediterranean fever may be advisable in the investigation of recurrent abdominal pain among children of Mediterranean extraction.
Brik
R
R
Department of Pediatrics, Pediatric Gastroenterology and Nutrition Unit, and the Institute of Human Genetics, Rambam Medical Center and Technion-Israel Institute of Technology, Faculty of Medicine, Haifa, Israel.
Litmanovich
D
D
Litmanovitz
D
D
Berkowitz
D
D
Shamir
R
R
Rosenthal
E
E
Shinawi
M
M
Gershoni-Baruch
R
R
D015746:Abdominal Pain / Q000235:genetics / Q000473:pathology; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D010505:Familial Mediterranean Fever / Q000453:epidemiology / Q000235:genetics*; D005260:Female; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D015994:Incidence; D008297:Male; D012008:Recurrence; D012307:Risk Factors