Sensitivity of Borrelia and Leptospira to Quinupristin-dalfopristin (Synercid) in vitro.
In vitro activity of Quinupristin-dalfopristin (Synercid) against seventeen isolates of Borrelia burgdorferi and two representatives of Leptospira spp. was investigated. MICs ranged from 0.03 to 0.125 for B. burgdorferi and 0.125-0.25 microg/ml for Leptospires. Time killing studies carried out with 2 MIC demonstrated U 3 log(10)-unit killing after 72 h, showing a significant activity against spirochetes, though at a lower level than other antibiotics in use in the therapy of Lyme disease and leptospirosis.
Murgia
R
R
Department of Biomedical Science, University of Trieste, Italy.
Cinco
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015748:Borrelia burgdorferi Group / Q000187:drug effects*; D007919:Leptospira / Q000187:drug effects*; D008193:Lyme Disease / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D013997:Time Factors; D014769:Virginiamycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D014769:Virginiamycin; C062940:quinupristin-dalfopristin