title: Haemostasis in relation to dietary fat as estimated by erythrocyte fatty acid composition: the prime study.
abstract: We investigated whether haemostatic variables were related with dietary fatty acid composition as estimated by the fatty acid content of erythrocytes. Subjects were a subsample (n=283) of the participants in the Prospective Epidemiological Study of Myocardial Infarction (PRIME) Study. Factor VII, fibrinogen, tissue-type plasminogen activator antigen (tPA-ag), plasminogen activator inhibitor type 1 (PAI-1), D-dimer and von Willebrand factor (vWf) were measured and the fatty acid composition was determined in the phospholipids of total erythrocytes by gas chromatography. Statistical analyses were performed using multiple linear regression analyses with adjustment for age, center and body mass index. tPA-ag was significantly related to the n-3 fatty acids derived from fish. This was reflected in an inverse association of all n-3 fatty acids combined with tPA-ag (beta=-0.37 ng/ml/%, 95% confidence intervals: -0.45, -0.29, P<.01). Positive and significant associations of D-dimer with arachidic and eicosamonoenoic acid were observed (P<.01). No relationships were found between fatty acids and fibrinogen, vWf, PAI-1 or factor VII. The results of this study suggest that consumption of n-3 fatty acids derived from fish may favourably influence tPA-ag.
authors.affiliation: INSERM Unité 258, Université Paris-Sud, Villejuif, France. scarabin@vjf.inserm.fr
authors.forename: P Y
authors.initials: PY
authors.lastname: Scarabin
authors.forename: M F
authors.initials: MF
authors.lastname: Aillaud
authors.forename: G
authors.initials: G
authors.lastname: Luc
authors.forename: B
authors.initials: B
authors.lastname: Lacroix
authors.forename: L
authors.initials: L
authors.lastname: Mennen
authors.forename: P
authors.initials: P
authors.lastname: Amouyel
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: J
authors.initials: J
authors.lastname: Ferrières
authors.forename: D
authors.initials: D
authors.lastname: Arveiler
authors.forename: I
authors.initials: I
authors.lastname: Juhan-Vague
mesh_terms: D015992:Body Mass Index; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004041:Dietary Fats / Q000494:pharmacology*; D004912:Erythrocytes / Q000737:chemistry*; D005167:Factor VII / Q000032:analysis*; D005227:Fatty Acids / Q000097:blood*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis*; D006487:Hemostasis / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology*; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D012907:Smoking; D010959:Tissue Plasminogen Activator / Q000097:blood; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D008076:Cholesterol, HDL; D004041:Dietary Fats; D005227:Fatty Acids; D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; D014841:von Willebrand Factor; D005167:Factor VII; D005340:Fibrinogen; D002784:Cholesterol; D010959:Tissue Plasminogen Activator