Intracellular assembly of VLDL: two major steps in separate cell compartments.
The assembly of very low-density lipoproteins (VLDL) occurs in two major steps. The first step is the co-and post-translational lipidation of apoB, forming pre-VLDL in the rough endoplasmic reticulum. The microsomal triglyceride transfer protein catalyzes this step. In the second step pre-VLDL is converted to bona fide VLDL in a smooth membrane compartment. This step depends on ADP-ribosylation factor 1 and its activation of phospholipase D.
Olofsson
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Department of Medical Biochemistry and the Wallenberg Laboratory for Cardiovascular Research, University of Göteborg, Göteborg, Sweden. Sven-Olof. Olofsson@mdkem.gu.se
Stillemark-Billton
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D053283:Apolipoprotein B-48; D001055:Apolipoproteins B / Q000097:blood / Q000378:metabolism*; D018870:Endoplasmic Reticulum, Rough / Q000378:metabolism*; D018871:Endoplasmic Reticulum, Smooth / Q000378:metabolism*; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism*; D015228:Hypertriglyceridemia / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood / Q000378:metabolism*
D053283:Apolipoprotein B-48; D001055:Apolipoproteins B; D008079:Lipoproteins, VLDL