[Polymorphism of catalase and glutathione peroxidase genes in macrovascular complications in patients with non-insulin-dependent diabetes mellitus and hypertension].
Allelic and genotypic distributions of the polymorphic markers C1167T and Pro197Leu of the genes of catalase (CAT) and glutathione peroxidase (GPX1), respectively, were studied in patients with non-insulin-dependent diabetes mellitus (NIDDM) and hypertension without complications (the control group, n = 52) and with complications: myocardial infarction (MI, n = 53) or stroke (n = 50). No significant differences were found between complicated and uncomplicated patients with respect to the allelic or phenotypic distribution. Thus, there were no association between these polymorphic regions and either MI or stroke in hypertensive NIDDM patients.
Sergeeva
T V
TV
State Research Institute for Genetics and Selection of Industrial Microorganisms, Moscow, 113545 Russia. dimitry.chistiakov@eudoramail.com
Chistiakov
D A
DA
Kobalava
Zh D
ZhD
Moiseev
V S
VS
D002318:Cardiovascular Diseases / Q000150:complications*; D002374:Catalase / Q000235:genetics*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications / Q000201:enzymology*; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D010641:Phenotype; D011110:Polymorphism, Genetic
D002374:Catalase; D005982:Glutathione Transferase