Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats.
We investigated the efficacy of a 4-wk supplementation of conjugated linoleic acid (CLA) as free fatty acid (FFA) or triacylglycerol (TG) on serum leptin concentration, body-fat accumulation, and mitochondrial beta-oxidation in Otsuka Long-Evans Tokushima Fatty (OLETF) rats. A significant reduction of serum leptin concentration (42%) and a decrease in the wet weights of perirenal, epididymal, and omental/visceral-adipose tissue in TG-CLA and FFA-CLA groups were found in comparison with the OLETF control group. Both forms of CLA supplementation produced a 5.2% decrease in body weight compared with the control even though food intake was similar in the OLETF groups. Moreover, both forms of CLA enhanced carnitine-palmitoyltransferase activity in brown adipose tissue, perirenal adipose tissue, red gastrocnemius muscle, and liver in comparison with the OLETF control group. Serum concentrations of non-esterified fatty acid and TG also were reduced in rats fed diets supplemented with TG-CLA and FFA-CLA.
Rahman
S M
SM
Department of Applied Biological Sciences, Saga University, Saga, Japan.
Wang
Y
Y
Yotsumoto
H
H
Cha
J
J
Han
S
S
Inoue
S
S
Yanagita
T
T
D000273:Adipose Tissue / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism; D004435:Eating / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D020738:Leptin / Q000097:blood*; D019787:Linoleic Acid / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D020334:Rats, Inbred OLETF; D016896:Treatment Outcome; D014280:Triglycerides / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D020738:Leptin; D014280:Triglycerides; D019787:Linoleic Acid; D002334:Carnitine O-Palmitoyltransferase