Tamoxifen citrate induced sperm shape abnormalities in the in vivo mouse.
The genotoxic potential of an anticancer drug, tamoxifen citrate, was studied in the in vivo mouse system using the sperm abnormality assay. Sperms of Swiss albino mice were examined after 5 weeks of repeated administration of different doses of the drug for 10 days. The doses used were 0.1, 0.2, 0.4 and 0.8 mg/kg b.w. per day. Statistically significant sperm abnormalities revealed the genotoxic potency of this drug.
Padmalatha Rai
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Department of Biotechnology, Kuvempu University, Jnana Sahyadri, 577451, Shimoga, India. root@shikuvem-kar.nic.in
Vijayalaxmi
K K
KK
D000284:Administration, Oral; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D013076:Sperm Count; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013629:Tamoxifen / Q000008:administration & dosage / Q000633:toxicity*; D013737:Testis / Q000187:drug effects / Q000473:pathology
D018931:Antineoplastic Agents, Hormonal; D009153:Mutagens; D013629:Tamoxifen