title: Coinfection with herpesviruses in young children of HIV-infected women.
abstract: Coinfection with herpesviruses in young children born to human immunodeficiency virus (HIV)-infected women was studied with blood samples from children who were 9-12 months and 15-24 months of age. Three groups of children were included: (I) HIV-uninfected, asymptomatic (HIV-); (II) polymerase chain reaction (PCR) and/or culture-positive and asymptomatic or mildly symptomatic (HIV+ asymptomatic); and (III) PCR and/or culture-positive and symptomatic (HIV+ symptomatic). Significantly more of the HIV+ symptomatic patients had cytomegalovirus (CMV) antibody than the HIV patients. In addition, CMV antibody levels were significantly higher in the HIV+ symptomatic patients than in either of the other two groups. Human herpesvirus 7 (HHV-7) antibody titers were significantly different among the three groups of patients; however, no pairwise comparisons were significant. No differences were found for HHV-6 or Epstein-Barr virus (EBV) antibody frequencies or titers. These findings suggest that infection with CMV is a cofactor or an opportunistic infection causing symptomatic HIV infections in young children.
authors.affiliation: Children's National Medical Center, George Washington University Medical Center, Washington, D.C., USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Sever
authors.forename: T A
authors.initials: TA
authors.lastname: Rakusan
authors.forename: M
authors.initials: M
authors.lastname: Ellaurie
authors.forename: N
authors.initials: N
authors.lastname: Frenkel
authors.forename: L S
authors.initials: LS
authors.lastname: Wyatt
authors.forename: J M
authors.initials: JM
authors.lastname: Campos
authors.forename: R M
authors.initials: RM
authors.lastname: O'Donnell
authors.forename: M V
authors.initials: MV
authors.lastname: Price
mesh_terms: D000914:Antibodies, Viral / Q000032:analysis; D018791:CD4 Lymphocyte Count; D016022:Case-Control Studies; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000276:immunology / Q000302:isolation & purification; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000276:immunology / Q000635:transmission; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology; D006566:Herpesviridae Infections / Q000150:complications* / Q000276:immunology; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000302:isolation & purification; D015654:Herpesvirus 6, Human / Q000276:immunology / Q000302:isolation & purification; D016199:Herpesvirus 7, Human / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000821:virology*
chemical_list: D000914:Antibodies, Viral; D007075:Immunoglobulin M