A magnetic resonance imaging study of the cervical cord of patients with CADASIL.
The authors obtained MR and magnetization transfer (MT) imaging of the cervical cord from 25 patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). They found no conventional MR abnormalities, but a reduced peak height of the MT ratio (MTR) histogram. This suggests a reduced amount of "truly" normal cord tissue in CADASIL. A significant correlation was found between the extent of brain lesions and cord MTR, suggesting wallerian degeneration as the substrate of the cord MTR changes.
Rocca
M A
MA
Neuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University Ospedale San Raffaele, Milan, Italy.
Filippi
M
M
Herzog
J
J
Sormani
M P
MP
Dichgans
M
M
Yousry
T A
TA
D000328:Adult; D000367:Age Factors; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002574:Cervical Vertebrae; D015161:Dementia, Multi-Infarct / Q000473:pathology* / Q000503:physiopathology; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013116:Spinal Cord / Q000473:pathology* / Q000503:physiopathology