Fatal progression of posttraumatic dural arteriovenous fistulas refractory to multimodal therapy. Case report.
The authors report the case of a man who suffered from progressive, disseminated posttraumatic dural arteriovenous fistulas (DAVFs) resulting in death, despite aggressive endovascular, surgical, and radiosurgical treatment. This 31-year-old man was struck on the head while playing basketball. Two weeks later a soft, pulsatile mass developed at his vertex, and the man began to experience pulsatile tinnitus and progressive headaches. Magnetic resonance imaging and subsequent angiography revealed multiple AVFs in the scalp, calvaria, and dura, with drainage into the superior sagittal sinus. The patient was treated initially with transarterial embolization in five stages, followed by vertex craniotomy and surgical resection of the AVFs. However, multiple additional DAVFs developed over the bilateral convexities, the falx, and the tentorium. Subsequent treatment entailed 15 stages of transarterial embolization; seven stages of transvenous embolization, including complete occlusion of the sagittal sinus and partial occlusion of the straight sinus; three stages of stereotactic radiosurgery; and a second craniotomy with aggressive disconnection of the DAVFs. Unfortunately, the fistulas continued to progress, resulting in diffuse venous hypertension, multiple intracerebral hemorrhages in both hemispheres, and, ultimately, death nearly 5 years after the initial trauma. Endovascular, surgical, and radiosurgical treatments are successful in curing most patients with DAVFs. The failure of multimodal therapy and the fulminant progression and disseminated nature of this patient's disease are unique.
Friedman
J A
JA
Department of Neurologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA. friedman.jonathan@mayo.edu
Meyer
F B
FB
Nichols
D A
DA
Coffey
R J
RJ
Hopkins
L N
LN
Maher
C O
CO
Meissner
I D
ID
Pollock
B E
BE
D000328:Adult; D001490:Basketball / Q000293:injuries; D001929:Brain Edema / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D020785:Central Nervous System Vascular Malformations / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D002533:Cerebral Angiography; D020202:Cerebral Hemorrhage, Traumatic / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery*; D003131:Combined Modality Therapy; D018450:Disease Progression; D004621:Embolization, Therapeutic; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D016634:Radiosurgery; D017211:Treatment Failure