title: [Effects of 3-N-butylphthalide on cortical calcineurin and calpain activities in focal cerebral ischemia rats].
abstract: OBJECTIVE
  To explore if the inhibitory effect of 3-n-butylphthalide(NBP) on apoptosis induced by transient focal cerebral ischemia in rats is relevant to cortical calcineurin and calpain activities.
  
  
  METHODS
  The model of cerebral ischemia-reperfusion was used. The activities of the two enzymes were measured by using biochemical methods.
  
  
  RESULTS
  DL-NBP and D-NBP 20 mg.kg-1 were found to significantly reduce ischemia ipsilateral cortical calcineurin and calpain activities. However, L-NBP 20 mg.kg-1 showed no obvious effect.
  
  
  CONCLUSIONS
  The anti-apoptotic effect of NBP may be relevant to its inhibition of calcineurin and calpain activities in focal cerebral ischemia rats.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
authors.forename: G X
authors.initials: GX
authors.lastname: Dong
authors.forename: Y P
authors.initials: YP
authors.lastname: Feng
mesh_terms: D000818:Animals; D001572:Benzofurans / Q000494:pharmacology*; D002545:Brain Ischemia / Q000378:metabolism*; D019703:Calcineurin / Q000187:drug effects*; D002154:Calpain / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects*; D008297:Male; D018696:Neuroprotective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism
chemical_list: D001572:Benzofurans; D018696:Neuroprotective Agents; C027125:3-n-butylphthalide; D019703:Calcineurin; D002154:Calpain