title: Synthesis of 1-(3-aminopropyl)-4-phenyl-1,2,4-triazolin-5-one and 1-(3-aminopropyl)-3,4-diphenyl-1,2,4-triazolin-5-one.
abstract: The reaction of 4-phenyl-1,2,4-triazolin-5-one [Ia] and 3,4-diphenyl-1,2,4-triazolin-5-one [Ib] with 1-bromo-3-chloropropane was carried out. The obtained compounds [IIa, b] were subjected to the reaction with secondary amines and ethylenediamine with resulted in 1-(3-aminopropyl)-1,2,4-triazolin-5-one derivatives.
authors.affiliation: Department of Organic Chemistry, Faculty of Pharmacy, Medical University, 6 Staszica Str., 20-081 Lublin, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Dobosz
authors.forename: A
authors.initials: A
authors.lastname: Maliszewska-Guz
authors.forename: M
authors.initials: M
authors.lastname: Struga
authors.forename: Z
authors.initials: Z
authors.lastname: Kleinrok
authors.forename: E
authors.initials: E
authors.lastname: Wielosz-Tokarzewska
authors.forename: E
authors.initials: E
authors.lastname: Jagiełło-Wójtowicz
mesh_terms: D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D014230:Triazoles; C045575:1,2,4-triazole