title: No evidence for linkage between COMT and schizophrenia in a French population.
abstract: Catechol-O-methyltransferase is a candidate in the predisposition to schizophrenia both because of its function and the position of its gene. A multipoint non-parametric linkage analysis and a transmission disequilibrium test were performed on 42 multiplex families genotyped for Pml I and Bcl I polymorphisms using two definitions of the affected phenotype. Neither linkage nor preferential transmission of any allele or haplotype was detected, failing to replicate previous positive findings.
authors.affiliation: LGN, UMR 9923 CNRS, Bâtiment CERVI, Hôpital de la Pitié-Salpêtrière, 83 boulevard de l'Hôpital, 75013, Paris, France.
authors.forename: M
authors.initials: M
authors.lastname: de Chaldée
authors.forename: M
authors.initials: M
authors.lastname: Corbex
authors.forename: D
authors.initials: D
authors.lastname: Campion
authors.forename: M
authors.initials: M
authors.lastname: Jay
authors.forename: D
authors.initials: D
authors.lastname: Samolyk
authors.forename: M
authors.initials: M
authors.lastname: Petit
authors.forename: F
authors.initials: F
authors.lastname: Thibaut
authors.forename: C
authors.initials: C
authors.lastname: Laurent
authors.forename: J
authors.initials: J
authors.lastname: Mallet
mesh_terms: D000483:Alleles; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D005602:France / Q000453:epidemiology; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D012559:Schizophrenia / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics
chemical_list: D002394:Catechol O-Methyltransferase