Arrhythmogenic left ventricular dysplasia' and sudden death.
A 32-year-old man who died suddenly and unexpectedly was found at autopsy to have prominent fatty infiltration of his left ventricle with fibrous scarring, in the presence of normal coronary arteries. The right ventricle was minimally involved. A diagnosis of ventricular dysplasia largely limited to the left ventricle was made. Subsequent family screening identified a brother with clinical manifestations of ventricular dysplasia. This case provides further evidence for the association of left ventricular dysplasia with sudden death, and demonstrates that left ventricular involvement may also be inheritable. Whether predominantly left ventricular dysplasia is a manifestation of right ventricular dysplasia, or is a separate entity, is yet to be determined.
Shrapnel
M
M
Tissue Pathology, Institute of Medical and Veterinary Science, Adelaide, South Australia.
Gilbert
J D
JD
Byard
R W
RW
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000150:complications* / Q000235:genetics / Q000473:pathology; D019571:Arrhythmogenic Right Ventricular Dysplasia; D003645:Death, Sudden / Q000209:etiology* / Q000473:pathology*; D006330:Heart Defects, Congenital / Q000150:complications* / Q000235:genetics / Q000473:pathology*; D006352:Heart Ventricles / Q000002:abnormalities*; D006801:Humans; D008297:Male