[Experimental study on mechanism of xiukeyin in anti-bacterial translocation from gut].
OBJECTIVE
To provide a TCM therapeutic base for treatment of critical multiple organ failure (MOF) patients clinically, the mechanism of Xiukeyin (XKY, Shock Beverage) in anti-bacterial translocation from gut in rats was studied.


METHODS
Based on the pathophysiology of MOF following severe injury, such as shock caused enterogenous-sepsis and bacterial translocation from gut, a hemorrhagic shock model of rat was established and used to determine the effect of XKY on anti-bacterial translocation. XKY was formulated by modifying Wenpi Decoction.


RESULTS
The incidence of intestinal bacterial translocation to mesenteric lymph nodes, liver and spleen was lower in the model rats infused via gastrogavage with XKY (3/15) than that in the noninfused rats (11/13) (P < 0.01). The amount and species of intestinal flora in XKY infused or noninfused rats were not different statistically (P > 0.05). Histological examination showed that the intestinal edema was severer in the model group than that in the XKY treated group.


CONCLUSIONS
XKY could inhibit the shock induced enterogenous bacterial translocation, the mechanism might be due to its protective action on intestinal mucosa. XKY showed no effect on the growth of intestinal bacteria.
Zhang
P
P
Zhejiang College of TCM, Hangzhou 310009.
Shui
W
W
Yang
W
W
D000818:Animals; D018988:Bacterial Translocation / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D007778:Lactobacillus / Q000502:physiology*; D008297:Male; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000382:microbiology
D004365:Drugs, Chinese Herbal