title: Bone response to implant-supported frameworks with differing degrees of misfit preload: in vivo study in rabbits.
abstract: OBJECTIVE
  To study the bone response around implants placed in tibia of rabbits that supported misfitting superstructures secured with different degrees of preload.
  
  
  METHODS
  Twelve rabbits were provided with two terminal 10-mm and one intermediate 7-mm-long implant in each tibia. After an integration time of about 9 weeks, nine of the animals received one control framework each (n = 9), designed with good fit to all three implants. In the other tibia of these animals, and in both tibias in the remaining three rabbits, test frameworks (n = 15) were connected with a vertical misfit of about 1 mm to the intermediate implant. The intermediate set screws were tightened with a torque ranging from 15 Ncm to 26 Ncm in the different test frameworks. The fascia and skin was then sutured back over the implants. After a loading period of 2 to 3 weeks, the animals were sacrificed, and histomorphometric measurements were made and correlated to the different levels of preload of the central implant.
  
  
  RESULTS
  The mean bone-to-metal contact for the three best consecutive threads of the central implant was 40% for both test and control sites (p > .05). Compared to the other regions of the implant thread, less bone-to-metal contact was found at the tip of the test implant threads in the low preload group (p < .05). However, the same relation was not observed in the high preload group. A significant correlation was observed between increasing degree of preload in the central screw joint and increasing bone-to-metal contact, most obviously noticed at the tip of the implant thread (p < .01).
  
  
  CONCLUSIONS
  Misfit stress levels of clinical magnitudes do not seem to jeopardize osseointegration per se. On the contrary, clinical levels of preload stress seem to significantly promote bone remodeling at the tip of the implant thread.
authors.affiliation: Brånemark Clinic, Dental Health Service and Faculty of Odontology, University of Gothenburg, Gothenburg, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Jemt
authors.forename: U
authors.initials: U
authors.lastname: Lekholm
authors.forename: C B
authors.initials: CB
authors.lastname: Johansson
mesh_terms: D000818:Animals; D016723:Bone Remodeling; D000044:Dental Abutments; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017268:Dental Prosthesis Retention; D019094:Dental Prosthesis, Implant-Supported; D003799:Dental Stress Analysis; D005260:Female; D020007:Implants, Experimental; D016348:Osseointegration; D017755:Prosthesis Fitting; D011817:Rabbits; D018709:Statistics, Nonparametric; D013314:Stress, Mechanical; D013977:Tibia; D019415:Torque
chemical_list: D015921:Dental Implants