title: [Immunomodulating properties of bidistilled modified water].
abstract: The effect of bidistilled modified water obtained by treating bidistilled water with static electric field in the cathode compartment of a diaphragm electrolyzer on the production of tumor necrosis factor and activity of natural killer cells of mice was studied. It was found that bidistilled modified water added to cultured murine macrophages increases the tumor necrosis factor production 2.5-3-fold. A similar degree of stimulation of tumor necrosis factor production was observed after peroral administration of bidistilled modified water for 10-25 days. The activity of natural killer cells under these conditions increased by 150%. The stimulation of these immunity system components responsible for the resistance of the organism to tumors led to a suppression of tumor growth in tumor-bearing mice receiving bidistilled modified water.
authors.affiliation: Institute of Cell Biophysics, Russian Academy of Sciences, Pushchino, Moscow Region, 142290 Russia.
authors.forename: E E
authors.initials: EE
authors.lastname: Fesenko
authors.forename: E G
authors.initials: EG
authors.lastname: Novoselova
authors.forename: V B
authors.initials: VB
authors.lastname: Ogaĭ
authors.forename: T A
authors.initials: TA
authors.lastname: Agafonova
authors.forename: O V
authors.initials: OV
authors.lastname: Glushkova
authors.forename: O A
authors.initials: OA
authors.lastname: Sinotova
authors.forename: F K
authors.initials: FK
authors.lastname: Aliushev
authors.forename: S M
authors.initials: SM
authors.lastname: Eremin
authors.forename: I A
authors.initials: IA
authors.lastname: Markov
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Ten
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000627:therapeutic use*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000276:immunology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004572:Electrolysis; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects; D007739:L Cells; D017737:Macrophages, Peritoneal / Q000378:metabolism; D008297:Male; D051379:Mice; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D014867:Water / Q000737:chemistry
chemical_list: D000276:Adjuvants, Immunologic; D014409:Tumor Necrosis Factor-alpha; D014867:Water