Genetic susceptibility to respiratory diseases.
As a result of the progress in molecular biology and genetics over the last 20 years, now it seems clear that the pathogenesis of most diseases is influenced by the genotype, the environment and the nature of the process which leads to the injury. Current evidence also suggests that genetic factors are associated with susceptibility to pulmonary diseases. The author reviews some of these complex interactions suggesting that even the inflammatory response during lung injury can be influenced by genetic polymorphisms.
Villar
J
J
Research Institute, Hospital N. S. de Candelaria, Carretera del Rosario, s/n, 38010 Santa Cruz de Tenerife, Canary Islands, Spain. jvillar@hcan.rcanaria.es
D000367:Age Factors; D001249:Asthma / Q000235:genetics; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007239:Infections / Q000401:mortality; D008171:Lung Diseases / Q000235:genetics* / Q000401:mortality; D008175:Lung Neoplasms / Q000235:genetics; D011110:Polymorphism, Genetic; D012128:Respiratory Distress Syndrome / Q000235:genetics; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D005819:Genetic Markers; D014409:Tumor Necrosis Factor-alpha