title: Post-partum retreatment with iridium-192 wire brachytherapy for meningioma recurring in pregnancy.
abstract: We report the case history of a female patient who had received radical radiotherapy for a malignant meningioma at the age of 11 years. Thirteen years later, during her first pregnancy, she presented with a recurrence. The tumour was surgically debulked, but complications related to postoperative sepsis, the location of the tumour, and the extent of her previous treatment made the delivery of adjuvant radiotherapy problematic. The tumour bed was treated using an interstitial implant of 192Ir wires to a dose of 60 Gy in 100 hours. The patient remains well with no evidence of tumour recurrence or brain necrosis 2 years later. We discuss the role of female sex hormones in meningioma and the difficulties of radical retreatment of tumours in the central nervous system. The various techniques of brachytherapy in the brain are highlighted. The specific advantages of 192Ir in this patient are discussed.
authors.affiliation: Department of Clinical Oncology, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, UK. sallyold@doctors.org.uk
authors.forename: S E
authors.initials: SE
authors.lastname: Old
authors.forename: N G
authors.initials: NG
authors.lastname: Burnet
authors.forename: R
authors.initials: R
authors.lastname: Macfarlane
authors.forename: D G
authors.initials: DG
authors.lastname: O'Donovan
authors.forename: K
authors.initials: K
authors.lastname: Langmack
mesh_terms: D000328:Adult; D001918:Brachytherapy; D005260:Female; D006801:Humans; D007496:Iridium Radioisotopes; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D009364:Neoplasm Recurrence, Local; D049590:Postpartum Period; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D011859:Radiography
chemical_list: D007496:Iridium Radioisotopes