title: Retrospective review of selective serotonin reuptake inhibitors and falling in older nursing home residents.
abstract: We compared the rate of falling in older nursing home residents who had been prescribed selective serotonin reuptake inhibitors (SSRIs), other classes of antidepressants, and no antidepressants. Data were obtained from pharmacy records, medical records, fall logs, and incidence reports for one nursing home (1995 data). Older adults on SSRIs were more likely to fall than older adults not on antidepressants (p = .003) and were more likely to have an injurious fall (p = .03). The association with falling remained significant even when including potential confounders (p = .007). Older nursing home residents should be treated for depression. However, SSRIs may also carry an increased risk for falling.
authors.affiliation: Department of Psychiatry and Behavioral Neurosciences, Center for Healthcare Effectiveness Research, Wayne State University School of Medicine, Detroit, Michigan 48201, USA. carfken@med.wayne.edu
authors.forename: C L
authors.initials: CL
authors.lastname: Arfken
authors.forename: J G
authors.initials: JG
authors.lastname: Wilson
authors.forename: S M
authors.initials: SM
authors.lastname: Aronson
mesh_terms: D000058:Accidental Falls / Q000517:prevention & control / Q000706:statistics & numerical data*; D000368:Aged; D000369:Aged, 80 and over; D000928:Antidepressive Agents / Q000009:adverse effects; D016022:Case-Control Studies; D003863:Depression / Q000188:drug therapy; D005260:Female; D050723:Fractures, Bone / Q000517:prevention & control; D006707:Homes for the Aged / Q000706:statistics & numerical data*; D006801:Humans; D007297:Inpatients / Q000523:psychology / Q000706:statistics & numerical data*; D016015:Logistic Models; D008297:Male; D008824:Michigan / Q000453:epidemiology; D009735:Nursing Homes / Q000706:statistics & numerical data*; D016017:Odds Ratio; D012189:Retrospective Studies; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D000928:Antidepressive Agents; D017367:Selective Serotonin Reuptake Inhibitors