Mechanisms of epileptogenesis.
The cellular mechanisms of epileptogenesis are reviewed as related to their role(s) in the expression of hyperexcitability and hypersynchrony. The data on the roles of the glutamate, GABA, acetylcholine, and adenosine receptors is discussed. The recent information on the role of glial cells in the expression of epileptogenicity is reviewed.
Najm
I
I
Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. najmi@ccf.org
Ying
Z
Z
Janigro
D
D
D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D002450:Cell Communication / Q000502:physiology; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D009457:Neuroglia / Q000378:metabolism; D018091:Receptors, AMPA / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D018091:Receptors, AMPA; D011950:Receptors, Cholinergic; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D005680:gamma-Aminobutyric Acid