Azasordarins: susceptibility of fluconazole-susceptible and fluconazole-resistant clinical isolates of Candida spp. to GW 471558.
The in vitro activity of the azasordarin GW 471558 was compared with those of amphotericin B, flucytosine, itraconazole, and ketoconazole against 177 clinical isolates of Candida spp. GW 471558 showed potent activity against Candida albicans, Candida glabrata, and Candida tropicalis, even against isolates with decreased susceptibility to azoles. Candida krusei, Candida parapsilosis, Candida lusitaniae, and Candida guilliermondii are resistant to GW 471558 in vitro (MICs, >128 microg/ml).
Cuenca-Estrella
M
M
Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda Madrid, Spain. mcuenca-estrella@isciii.es
Mellado
E
E
Díaz-Guerra
T M
TM
Monzón
A
A
Rodríguez-Tudela
J L
JL
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D007192:Indenes; D008826:Microbial Sensitivity Tests; D009025:Morpholines; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology*; D013030:Spain
D000935:Antifungal Agents; C433787:GW 471558; D007192:Indenes; D009025:Morpholines; D011500:Protein Synthesis Inhibitors