[Effects of human papillomavirus infection on pregnant women and chorionic trophoblasts].
OBJECTIVE
To evaluate the effects of human papilloma virus (HPV) infection on pregnant women and chorionic trophoblasts.


METHODS
The morphological characters were observed from 62 pregnant women with codyloma acuminatum during the first and second trimester. In situ hybridization (ISH) was performed to detect HPV 6/11 in chorionic villi of all these cases. In 10 cases, ISH was also performed in condyloma acuminatum of vulva, vaginal and cervix. In 10 cases HPV 6/11 was detected by polymerase chain reaction (PCR) in chorionic villi as well.


RESULTS
The lesions condyloma acuminatum developed rapidly during pregnancy. Multiple lesions were found usually, and the gross appearances and histological features were more typical. Using ISH and PCR to detect HPV 6/11-DNA in chorionic villi all showed negative. 8 of 10 cases were positive in condyloma acuminatum sites by ISH.


CONCLUSIONS
HPV infection does not make vertical transmission during first and second trimester. It does not increase the potential risk for the fetus.
Chen
X
X
Affiliated Obstetrics and Gynecology Hospital, Zhejiang University, Hangzhou 310006.
Zhao
C
C
Zhang
Y
Y
D000328:Adult; D002478:Cells, Cultured; D003218:Condylomata Acuminata / Q000821:virology*; D005260:Female; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000635:transmission; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000821:virology*; D014327:Trophoblasts / Q000166:cytology / Q000821:virology; D014412:Tumor Virus Infections / Q000635:transmission