title: New artificial siderophores based on a monosaccharide scaffold.
abstract: New artificial catecholate siderophores with methyl alpha-D-glucopyranoside as scaffold were synthesized. The dihydroxy- or di(acetoxy)benzoyl moieties were attached either directly or via aminopropyl spacer groups, to the carbohydrate scaffold. The siderophore activity of the prepared siderophore analogs was examined by a growth promotion assay using various Gram-negative bacteria and mycobacteria and by the CAS-assay.
authors.affiliation: Hans Knöll-Institut für Naturstoff-Forschung, Jena, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Heggemann
authors.forename: M
authors.initials: M
authors.lastname: Schnabelrauch
authors.forename: D
authors.initials: D
authors.lastname: Klemm
authors.forename: U
authors.initials: U
authors.lastname: Möllmann
authors.forename: R
authors.initials: R
authors.lastname: Reissbrodt
authors.forename: L
authors.initials: L
authors.lastname: Heinisch
mesh_terms: D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008757:Methylglucosides / Q000737:chemistry; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects / Q000254:growth & development; D017262:Siderophores / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D008757:Methylglucosides; D017262:Siderophores; C027020:methylglucoside