title: 7-Chloro-1-(2,6-difluorophenyl)-1H,3H-thiazolo.
abstract: The title molecules, C(15)H(9)ClF(2)N(2)S and C(16)H(12)F(2)N(2)S, respectively, display the well known butterfly-like conformation with a flat thiazolobenzimidazole system. In both compounds, the mean plane through the tricyclic system is almost perpendicular to the 2,6-difluorophenyl ring. This arrangement of the aryl group is determined by two intramolecular hydrogen bonds and by an attractive F.S interaction.
authors.affiliation: Dip. di Chimica Inorganica, Chimica Analitica e Chimica Fisica, Universitá degli Studi di Messina, Via Salita Sperone 31, I-98166 Vill. S. Agata, Messina, Italy. fnicolo@unime.it
authors.forename: F
authors.initials: F
authors.lastname: Nicoló
authors.forename: G
authors.initials: G
authors.lastname: Bruno
authors.forename: R
authors.initials: R
authors.lastname: Scopelliti
authors.forename: S
authors.initials: S
authors.lastname: Grasso
authors.forename: A
authors.initials: A
authors.lastname: Rao
authors.forename: M
authors.initials: M
authors.lastname: Zappalá
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D008968:Molecular Conformation; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000737:chemistry* / Q000494:pharmacology
chemical_list: C431291:1-(2,6-difluorophenyl)-6-methyl-1H,3H-thiazolo(3,4-a)benzimidazole; C431290:7-chloro-1-(2,6-difluorophenyl)-1H,3H-thiazolo(3,4-a)benzimidazole; D019380:Anti-HIV Agents; D001562:Benzimidazoles; D013844:Thiazoles