The correlation of TERT expression with c-myc expression in cervical cancer.
Recently putative catalytic telomerase subunit was identified as telomerase reverse transcriptase (TERT). Several reports showed that TERT expression correlated with telomerase activity. It has also been found that c-myc can induce telomerase activation through TERT expression. We examined expression of TERT and c-myc and their correlation in cervical cancers by reverse transcription-polymerase chain reaction (RT-PCR). It was found that TERT and c-myc expression was observed mostly in malignancies and expression of c-myc was concordant for positivity and negativity with TERT. These results support recent studies that c-myc expression is closely associated with TERT and telomerase activity. c-myc up-regulation may play an important role in activation of TERT and telomerase.
Sagawa
Y
Y
Department of Obstetrics and Gynecology, Tokyo Medical University,6-7-1 Nishishinjuku Shinjuku-ku, 160-0023, Tokyo, Japan.
Nishi
H
H
Isaka
K
K
Fujito
A
A
Takayama
M
M
D002584:Cervix Uteri / Q000378:metabolism; D004268:DNA-Binding Proteins; D005260:Female; D006367:HeLa Cells; D006801:Humans; D016133:Polymerase Chain Reaction; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis*; D012313:RNA; D012333:RNA, Messenger / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D019098:Telomerase / Q000096:biosynthesis* / Q000378:metabolism; D014407:Tumor Cells, Cultured; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000473:pathology
D004268:DNA-Binding Proteins; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; C422952:telomerase RNA; D012313:RNA; C509186:TERT protein, human; D019098:Telomerase