Structure-based design of non-peptide HIV protease inhibitors.
A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.
Ghosh
A K
AK
Department of Chemistry, University of Illinois at Chicago, IL 60607, USA. arunghos@uic.edu
Shin
D
D
Swanson
L
L
Krishnan
K
K
Cho
H
H
Hussain
K A
KA
Walters
D E
DE
Holland
L
L
Buthod
J
J
D015195:Drug Design; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D017320:HIV Protease Inhibitors