title: A retro-inverso Prosaptide D5 promotes a myelination process in developing rats.
abstract: The myelinotrophic action of Prosaptide D5 was investigated in developing rats. Sulfatide concentrations in brain and sciatic nerve were determined to assess the development of myelination. Subcutaneous D5-injection significantly increased sulfatide concentrations in both brain and sciatic nerve by 250 and 150% over controls, respectively. D5 promoted ERK phosphorylation in iSC Schwann cells similar to prosaposin. The results showed that D5 treatment stimulated a myelination process in developing rat.
authors.affiliation: Department of Neurosciences, University of California at San Diego, School of Medicine, Center for Molecular Genetics, La Jolla, CA 92093-0634, USA. mhiraiwa@ucsd.edu
authors.forename: M
authors.initials: M
authors.lastname: Hiraiwa
authors.forename: W M
authors.initials: WM
authors.lastname: Campana
authors.forename: C Y
authors.initials: CY
authors.lastname: Wang
authors.forename: D A
authors.initials: DA
authors.lastname: Otero
authors.forename: J S
authors.initials: JS
authors.lastname: O'Brien
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006128:Growth; D007279:Injections, Subcutaneous; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009186:Myelin Sheath / Q000187:drug effects* / Q000502:physiology*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009994:Osmolar Concentration; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells / Q000187:drug effects / Q000378:metabolism; D012584:Sciatic Nerve / Q000187:drug effects / Q000378:metabolism; D013433:Sulfoglycosphingolipids / Q000378:metabolism
chemical_list: D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D013433:Sulfoglycosphingolipids; C404155:prosaptide D5; D020928:Mitogen-Activated Protein Kinases