title: Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity.
abstract: A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa,9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.
authors.affiliation: College of Pharmacy, Chungnam National University, Taejon, South Korea.
authors.forename: N H
authors.initials: NH
authors.lastname: Nam
authors.forename: Y J
authors.initials: YJ
authors.lastname: You
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: D H
authors.initials: DH
authors.lastname: Hong
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
authors.forename: B Z
authors.initials: BZ
authors.lastname: Ahn
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D002934:Cinnamates / Q000737:chemistry; D006801:Humans; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D002109:Caffeic Acids; D002934:Cinnamates; D011407:Propane