Isolation and structures of hedaols A, B, and C, new bisnorditerpenes from a Japanese brown alga.
New bisnorditerpenes, hedaols A (1), B (2), and C (3), were isolated from the Japanese brown alga Sargassum sp. Their structures were determined by spectroscopic analysis. The absolute stereocenter of 1 was determined by the modified Mosher's method. Hedaols showed low cytotoxicity against P388 cells.
Takada
N
N
Department of Chemistry, Graduate School of Science, and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
Watanabe
R
R
Suenaga
K
K
Yamada
K
K
Uemura
D
D
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D000459:Phaeophyceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes; C433956:hedaol A; C433957:hedaol B; C433958:hedaol C