Abnormalities of sodium pump function in hypertension and the role of endogenous cardiotonic steroids.
Elevated arterial blood pressure is a common heritable susceptibility in the human population. The high penetrance of this trait in industrialized societies may be influenced by the interactions of environmental factors and common genetic variants. This review examines the role of the renal sodium pump (sodium, potassium-ATPase, NKA) in hypertension and its integration into mechanisms of body sodium balance. In particular, renal NKA provides an appealing target by which inherited factors caninfluence renal sodium reabsorption. Recent work has indicated how some such genetic mechanisms may function. In this paper, the capacity of renal NKA to integrate environmental and heritable factors to increase blood pressure are examined.
Doris
P A
PA
Institute of Molecular Medicine, University of Texas Health Science Center at Houston, 77030, USA. pdoris@imm2.imm.uth.tmc.edu
D000042:Absorption; D000818:Animals; D001794:Blood Pressure; D002018:Bufanolides / Q000378:metabolism; D002301:Cardiac Glycosides / Q000378:metabolism*; D004734:Energy Metabolism; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics; D007668:Kidney / Q000201:enzymology* / Q000378:metabolism; D010042:Ouabain / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D002018:Bufanolides; D002301:Cardiac Glycosides; C093896:marinobufagenin; D010042:Ouabain; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase