Antiinflammatory effects of Cordia myxa fruit on experimentally induced colitis in rats.
Products of certain species of Cordia are reported to have antiinflammatory properties. In the present study we examined the effects of Cordia myxa fruit on experimentally induced colitis in rats. Colitis was induced by intrarectal administration of 4% acetic acid. Colitic, normal, and corresponding control animals were included. Body weight was recorded daily. All the animals were sacrificed 4 days after the fruit treatment. Colitis was monitored histologically and by activity of myeloperoxidase. Glutathione peroxidase, superoxide dismutase, as well as total antioxidant status and concentrations of zinc, copper, manganese, selenium, and iron were assayed in plasma, liver, and colon using standard methods. Histology of the colon of colitic rats showed acute colitis that was confirmed by a significant increase in the myeloperoxidase activity. Colitis was associated with significant decreases in the tissue activities of glutathione peroxidase and superoxide dismutase and lower concentrations of trace elements. Histologic examination and myeloperoxidase activity showed that the fruit treatment reversed the above findings in the inflamed colon, and in liver and plasma of colitic rats. The present results suggest that the observed antiinflammatory effect of the Cordia myxa may be attributed partly to its antioxidant property and to restoration of the levels of trace elements in the inflamed colon, liver, and plasma.
Al-Awadi
F M
FM
Department of Biochemistry, Faculty of Medicine, Kuwait University, Safat, Kuwait. farida@hsc.kuniv.edu.kw
Srikumar
T S
TS
Anim
J T
JT
Khan
I
I
D019342:Acetic Acid / Q000008:administration & dosage; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D000975:Antioxidants / Q000378:metabolism; D028082:Boraginaceae / Q000737:chemistry; D003092:Colitis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D003106:Colon / Q000378:metabolism / Q000473:pathology; D005638:Fruit / Q000737:chemistry*; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D014131:Trace Elements / Q000032:analysis
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D010936:Plant Extracts; D014131:Trace Elements; D009195:Peroxidase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D019342:Acetic Acid