Interconnected large-scale systems for three fundamental cognitive tasks revealed by functional MRI.
The specific brain areas required to execute each of three fundamental cognitive tasks - object naming, same-different discrimination, and integer computation - are determined by whole-brain functional magnetic resonance imaging (fMRI) using a novel technique optimized for the isolation of neurocognitive systems. This technique (1) conjoins the activity associated with identical or nearly identical tasks performed in multiple sensory modalities (conjunction) and (2) isolates the activity conserved across multiple subjects (conservation). Cortical regions isolated by this technique are, thus, presumed associated with cognitive functions that are both distinguished from primary sensory processes and from individual differences. The object-naming system consisted of four brain areas: left inferior frontal gyrus, Brodmann's areas (BAs) 45 and 44; left superior temporal gyrus, BA 22; and left medial frontal gyrus, BA 6. The same-different discrimination system consisted of three brain areas: right inferior parietal lobule, BA 40; right precentral gyrus, BA 6; and left medial frontal gyrus, BA 6. The integer computation system consisted of five brain areas: right middle frontal gyrus, BA 6; right precentral gyrus, BA 6; left inferior parietal lobule, BA 40; left inferior frontal gyrus, BA 44; and left medial frontal gyrus, BA 6. All three neurocognitive systems shared one common cortical region, the left medial frontal gyrus, the object-naming and integer computation systems shared the left inferior frontal gyrus, and the integer computation and same-different discrimination systems shared the right precentral gyrus. These results are consistent with connectionist models of cognitive processes where specific sets of remote brain areas are assumed to be transiently bound together as functional units to enable these functions, and further suggest a superorganization of neurocognitive systems where single brain areas serve as elements of multiple functional systems.
Hirsch
J
J
Memorial Sloan-Kettering Cancer Center, Cornell University, New York, NY 10021, USA. hirsch@vision.mskcc.org
Moreno
D R
DR
Kim
K H
KH
D000328:Adult; D001307:Auditory Perception / Q000502:physiology*; D001921:Brain / Q000502:physiology; D003071:Cognition / Q000502:physiology*; D004192:Discrimination, Psychological / Q000502:physiology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D014110:Touch / Q000502:physiology*; D014796:Visual Perception / Q000502:physiology*