title: Coagulation and fibrinolysis disorder in muscular dystrophy.
abstract: To investigate whether there are any basic abnormalities of coagulation and fibrinolysis in muscular dystrophy, we measured serum levels of the MM isozyme of creatine kinase (CK-MM), fibrin and fibrinogen degradation products (FDP), plasma levels of fibrinogen, antithrombin (AT), and D-dimer in 36 patients with Duchenne muscular dystrophy (DMD), 11 with Becker muscular dystrophy (BMD), 5 with Fukuyama congenital muscular dystrophy (FCMD), 5 with myotonic dystrophy (MyD), and 5 with spinal muscular atrophy (SMA) type 2. FDP levels were elevated in the patients with DMD, BMD, and FCMD (1.0 to 84.9 microg/ml), but not in the patients with MyD and SMA type 2. In DMD, BMD, and FCMD, FDP levels significantly correlated with CK-MM, but not with age, fibrinogen, AT, D-dimer, and type of dystrophy (multiple regression analysis; r(2) = 0.814, P < 0.0001). These findings suggested that enhanced coagulation and fibrinolysis are associated with muscle degeneration in patients with DMD, BMD, and FCMD.
authors.affiliation: Department of Neurology, Toneyama National Hospital, 5-1-1 Toneyama, Toyonaka, Osaka, 560-8552, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Saito
authors.forename: M
authors.initials: M
authors.lastname: Takenaka
authors.forename: I
authors.initials: I
authors.lastname: Miyai
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Matsumura
authors.forename: S
authors.initials: S
authors.lastname: Nozaki
authors.forename: J
authors.initials: J
authors.lastname: Kang
mesh_terms: D000293:Adolescent; D000328:Adult; D001778:Blood Coagulation Disorders / Q000150:complications*; D002648:Child; D003402:Creatine Kinase / Q000097:blood; D052283:Creatine Kinase, MM Form; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005338:Fibrin Fibrinogen Degradation Products / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006333:Heart Failure / Q000097:blood / Q000150:complications*; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D008297:Male; D020388:Muscular Dystrophy, Duchenne / Q000097:blood / Q000150:complications*; D012044:Regression Analysis; D014897:Spinal Muscular Atrophies of Childhood / Q000097:blood / Q000150:complications
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D007527:Isoenzymes; C036309:fibrin fragment D; D005337:Fibrin; D005340:Fibrinogen; D003402:Creatine Kinase; D052283:Creatine Kinase, MM Form