title: Selected biochemical parameters of blood serum in soldiers committing self-mutilation.
abstract: OBJECTIVE
  This project attempts to establish a possible link between selected biochemical parameters (cholesterol and triglyceride concentrations and levels of malonyl dialdehyde and superoxide dismutase) in soldiers with autoaggressive behaviors.
  
  
  METHODS
  The study involved 33 soldiers treated for self-aggressive behavior from July 1, 1998, to June 30, 1999. Average patient age was 20.7 years. The control group consisted of 21 soldiers hospitalized for mental disturbances but not showing autoaggressive tendencies. Total cholesterol and activity of platelets, considering the generation of free radicals and triglyceride concentration levels, were determined in the blood serum of members of both groups.
  
  
  RESULTS
  The results indicate significantly lower concentrations of total cholesterol in the serum of soldiers showing self-aggressive behaviors. Also, increased concentrations of malonyl dialdehyde in blood platelets and decreased superoxide dismutase activity were found in individuals prone to autoaggression.
  
  
  CONCLUSIONS
  The results suggest that the dysfunction of oxidation-reduction processes in brain tissue leads to excessive generation of free radicals, which can cause brain cell damage and disturb metabolic processes, resulting in mental disturbances that may constitute a background for self-aggressive behavior. The decreased activity of superoxide dismutase is a major factor in the observed oxidation-reduction disturbances.
authors.affiliation: Department of Psychiatry, Military Medical University, Aleksandrowska Strasse 159, 91-360 Lodz, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Florkowski
authors.forename: W
authors.initials: W
authors.lastname: Gruszczynski
authors.forename: Z
authors.initials: Z
authors.lastname: Wawrzyniak
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood; D001792:Blood Platelets / Q000473:pathology; D002784:Cholesterol / Q000097:blood*; D005609:Free Radicals; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D008889:Military Personnel; D010084:Oxidation-Reduction; D010554:Personality Disorders / Q000378:metabolism*; D012652:Self Mutilation / Q000097:blood*; D013482:Superoxide Dismutase / Q000097:blood; D014280:Triglycerides / Q000097:blood*
chemical_list: D015415:Biomarkers; D005609:Free Radicals; D014280:Triglycerides; D008315:Malondialdehyde; D002784:Cholesterol; D013482:Superoxide Dismutase