Changes in rat adipocyte and liver glucose metabolism following repeated restraint stress.
Rats exposed to repeated restraint weigh less than controls even 8 weeks after stress. Stress-induced weight loss is lean tissue, but the post-stress difference in weight between control and restrained rats is lean and fat mass. Whole-body glucose clearance is enhanced 1 day after stress, but adipocyte glucose utilization is inhibited and muscle glucose transport is unchanged. The studies described here demonstrated that glucose transport was increased in both restrained and pair-fed rats, but that glycogen synthesis was increased only in restrained rats, which may account for the improved whole-body glucose clearance. Adipocyte glucose transport was inhibited and adipose plasma membrane beta-adrenergic receptor number was increased 1 day post-stress in restrained rats when weight loss was lean tissue, but were not different from control rats 5 days post-stress, when both fat and lean tissue were reduced. Thus, repeated restraint induces reversible changes in adipocyte metabolism that may represent a transition from the catabolic state of stress to a new energetic equilibrium in rats that maintain a reduced body weight for an extended period of time.
Zhou
J
J
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA. Zhouj@pbrc.edu
Shi
M X
MX
Mitchell
T D
TD
Smagin
G N
GN
Thomas
S R
SR
Ryan
D H
DH
Harris
R B
RB
D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport; D001835:Body Weight; D004435:Eating; D005947:Glucose / Q000378:metabolism*; D006003:Glycogen / Q000096:biosynthesis; D050356:Lipid Metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000209:etiology / Q000378:metabolism*; D013997:Time Factors
D006003:Glycogen; D005947:Glucose