[The side effect and complication of intraarterial phosphorus-32 glass microspheres for patients with advanced hepatoma].
The phosphorus-32 glass microspheres(32P-GMS) is a new radioembolizer for cancer therapy. From March 1994 to April 1995, 24 patients with unresectable hepatocellular carcinoma and 3 patients with cavernous hemangioma received internal radiation treatment of 32P-GMS. The clinical results demonstrated that hepatic arterial instillation of 32P-GMS appeared to be safe and effective for hepatocellular carcinoma. There was no significant bone marrow or renal toxicity or liver to pulmonary bypass. A transient change of liver function and fever occurred in almost all patients. Significant liver toxicity and gastrointestinal tract reaction were seen when radiation dose > 50 Gy or microspheres > 3 g, and then various postoperative complications occurred.
Li
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Department of Surgery, First University Hospital, West China University of Medical Sciences, Chengdu 610041.
Yan
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Chen
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D000328:Adult; D001918:Brachytherapy / Q000379:methods; D006528:Carcinoma, Hepatocellular / Q000556:secondary / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000379:methods*; D005260:Female; D005334:Fever / Q000209:etiology; D005898:Glass; D006392:Hemangioma, Cavernous / Q000628:therapy; D006505:Hepatitis / Q000209:etiology; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D010761:Phosphorus Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D011829:Radiation Dosage
D010761:Phosphorus Radioisotopes