title: [Transdermal delivery mechanisms of lecithin nanoparticles with cyclosporin A through mice skin].
abstract: OBJECTIVE
  To investigate the transdermal delivery mechanisms of the flexible nano-liposomes, conventional nano-liposomes and lecithin-cholate mixed micelles through mouse skin.
  
  
  METHODS
  Liposomes and micelles were applied onto the mouse skin non-occlusively in vitro and in vivo, then the drug concentrations in the skin, receiver and blood were determined.
  
  
  RESULTS
  In vitro permeation studies showed that flexible nano-liposomes and mixed micelles transported measurable amount of cyclosporin A through the skin. Conventional liposomes precluded drugs permeate through the skin while deposited it in the skin. In vivo studies indicated that blood concentration reached peak value at 8 h after the application of flexible nano-liposomes. Both conventional nano-liposomes and mixed micelles failed to deliver measurable amount of drug into the blood.
  
  
  CONCLUSIONS
  Liposomes fuse with the skin. Flexible nano-liposomes penetrate through the skin under the pressure of hydration force. Mixed micelles promote transfer in state of solution.
authors.affiliation: Department of Pharmaceutics, China Pharmaceutical University, Nanjing 210009, China.
authors.forename: J X
authors.initials: JX
authors.lastname: Guo
authors.forename: Q N
authors.initials: QN
authors.lastname: Ping
authors.forename: T
authors.initials: T
authors.lastname: Wu
mesh_terms: D000279:Administration, Cutaneous; D000818:Animals; D016572:Cyclosporine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008081:Liposomes; D051379:Mice; D008823:Micelles; D010539:Permeability; D012869:Skin Absorption
chemical_list: D008081:Liposomes; D008823:Micelles; D016572:Cyclosporine