Adsorptive stripping voltammetric determination of antihypertensive agent: diltiazem.
Adsorptive stripping voltammetry was used to determine the antihypertensive agent diltiazem in phosphate buffer (pH 7.0). The adsorptive cathodic peak was observed at -1.72 V vs. Ag/AgCl. The peak response was characterized with respect to pH, preconcentration time, possible interferences, accumulation potential and supporting electrolytes. The obtained results were analyzed and the statistical parameters were calculated. The proposed method was applied to determine the mentioned drug in pharmaceutical formulation (capsule) and urine. The detection limit is 1x10(-8) M (4.5 ng ml(-1)) using 180 s preconcentration time, whereas the lower limit of detection is 6x10(-9) M (2.7 ng ml(-1)).
Ghandour
M A
MA
Chemistry Department, Faculty of Science, Assiut University, 71516, Assiut, Egypt. ghandour@aun.eun.eg
Aboul Kasim
E
E
Ali
A M
AM
El-Haty
M T
MT
Ahmed
M M
MM
D000959:Antihypertensive Agents / Q000032:analysis*; D002214:Capsules; D004110:Diltiazem / Q000032:analysis* / Q000652:urine; D004563:Electrochemistry; D006801:Humans
D000959:Antihypertensive Agents; D002214:Capsules; D004110:Diltiazem