Mutation analysis of a Mauritian hereditary breast cancer family reveals the BRCA2 6503deITT mutation previously found to recur in different ethnic populations.
Mauritius, a small island some 855 km off the east coast of Madagascar, has a multiethnic population of about 1.2 million with a high population density of about 611 per km(2). The recent industrialization of the island seems to have been accompanied, in less than 10 years, by an increase of at least 30% in breast cancer incidence. We have detected the BRCA2 6503delTT mutation in two sisters of the same family of Indian origin but living in Mauritius for at least five generations. This mutation has been found to recur in geographically diverse populations and haplotype analysis has shown a common ancestry. The haplotype of the mutation found in the Mauritian family differs from that found in other populations harbouring the same mutation, suggesting that the BRCA2 6503delTT mutation most likely arose independently.
Khittoo
G
G
Faculty of Science, University of Mauritius, Reduit, Mauritius. gkhittoo@uom.ac.mu
Manning
A
A
Mustun
H
H
Appadoo
J
J
Venkatasamy
S
S
Fagoonee
I
I
Ghadirian
P
P
Tonin
P N
PN
D024682:BRCA2 Protein; D001943:Breast Neoplasms / Q000235:genetics*; D002882:Chromosomes, Human, Pair 13; D005260:Female; D017353:Gene Deletion; D018095:Germ-Line Mutation; D006239:Haplotypes; D006801:Humans; D008297:Male; D008436:Mauritius; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000235:genetics*; D010375:Pedigree; D014157:Transcription Factors / Q000235:genetics*
D024682:BRCA2 Protein; D009363:Neoplasm Proteins; D014157:Transcription Factors