title: Glaucoma surgery with or without adjunctive antiproliferatives in normal tension glaucoma: 2 Visual field progression.
abstract: BACKGROUND
  Reduction of intraocular pressure by 20-30% with glaucoma drainage surgery slows disease progression in normal tension glaucoma (NTG). It is not clear whether adjunctive antiproliferative agents are necessary or safe in eyes at low risk for scarring.
  
  
  METHODS
  61 eyes of 61 white patients with NTG who had undergone a primary guarded fistulising procedure were reviewed. 20 eyes had no antiproliferatives (nil), 29 had peroperative 5-fluorouracil (5-FU), and 12 had peroperative mitomycin C (MMC). Pointwise linear regression analysis (PROGRESSOR for Windows software) was applied to their visual field series starting with the first visual field following surgery and adding subsequent visual fields one at a time. Progression of visual field loss was defined as the appearance of a regression slope 1 dB per year or more with a significance of p<0.01 at one or more visual field locations which remained consistent with the addition of two of three successive visual fields. Time updated covariate analysis was used to determine the relation between variables that changed with time, such as IOP, and the risk of progression.
  
  
  RESULTS
  The median percentage IOP reduction was 24.4 for the nil group, 38.0 for the 5-FU group, and 47.5 for the MMC group (p=0.001). There was a statistically significant relation between percentage change in IOP and risk of visual field progression in the subsequent 6 month period for all patients analysed as one group, hazard ratio = -0.021 (p=0.002). There was a statistically significantly increase in the risk of visual field progression for the MMC group compared with the 5-FU group, hazard ratio = 1.51 (p=0.02).
  
  
  CONCLUSIONS
  In NTG patients, the IOP reduction produced by drainage surgery reduces the risk that visual field progression may be reduced after drainage surgery; this is related to the level of IOP reduction. The percentage drop in IOP during a given time is related to the risk of subsequent visual field progression. However, the use of MMC is associated with a greater risk of visual field progression despite a greater fall in IOP. This visual field deterioration may be related to the functional loss produced by late postoperative complications which have been reported at a higher rate in this group. The use of adjunctive perioperative 5-FU should maintain a suitable target IOP with preservation of visual function without the additional complications and associated visual deterioration seen with adjunctive MMC.
authors.affiliation: Glaucoma Unit, Moorfields Eye Hospital, City Road, London EC1V 2PD, UK.
authors.forename: W L
authors.initials: WL
authors.lastname: Membrey
authors.forename: C
authors.initials: C
authors.lastname: Bunce
authors.forename: D P
authors.initials: DP
authors.lastname: Poinoosawmy
authors.forename: F W
authors.initials: FW
authors.lastname: Fitzke
authors.forename: R A
authors.initials: RA
authors.lastname: Hitchings
mesh_terms: D000368:Aged; D000963:Antimetabolites / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005902:Glaucoma, Open-Angle / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000209:etiology; D012189:Retrospective Studies; D018709:Statistics, Nonparametric; D016019:Survival Analysis; D014130:Trabeculectomy / Q000379:methods*; D016896:Treatment Outcome; D014794:Visual Fields
chemical_list: D000963:Antimetabolites; D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin; D005472:Fluorouracil