Reflux esophagitis and airway hyperresponsiveness.
OBJECTIVE
To observe the effects of reflux esophagitis(RE) on the lung function and airway reactivity, and study the mechanism of airway hyperresponsiveness(AHR) in patients with RE.


METHODS
Lung function measurements and airway provocation tests were performed in 31 RE patients and 35 control subjects. TXB2 and PGF1a were determined in 20 cases of each group.


RESULTS
In RE patients the lung function was lower and the rate of AHR was higher than control subjects (P < 0.05). Among RE patients 25% had higher airway sensitivity (Dmin < 3 u). The TXB2 of RE patients with AHR was higher than those without AHR. Dmin correlated significantly with TXB2 (r = -0.653, P < 0.05).


CONCLUSIONS
RE could damage the lung function. The rate of AHR was 61%, the high airway sensitivity was probably potential asthma, and TXB2 may play a role in the pathogenesis of AHR.
Song
Y
Y
First Affiliated Hospital of Shanxi Medical University, Taiyuan 030001.
Li
G
G
D000328:Adult; D000368:Aged; D016535:Bronchial Hyperreactivity / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D004942:Esophagitis, Peptic / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011460:Prostaglandins F / Q000097:blood; D012129:Respiratory Function Tests; D013929:Thromboxane B2 / Q000097:blood
D011460:Prostaglandins F; D013929:Thromboxane B2; C100006:prostaglandin F1