[Treatment options of clomiphene-resistant polycystic ovary syndrome related infertility].
OBJECTIVE
To investigate the treatment options of clomiphene(CC)-resistant polycystic ovary syndrome (PCOS) related infertility.


METHODS
Fifty-nine PCOS patients with CC resistant-anovulation were accepted and treated by the following three protcols: (1) follicle-stimulating hormone (FSH) group, 49 cycles; (2) FSH + pulsatile gonadotropin-releasing hormone(GnRH) group, 13 cycles; (3) conventional in vitro fertilization (IVF)-embryo transfer (ET) group, 19 cycles. Suppressive treatment on serum luteinising hormone (LH) and testosterone (T) levels was given in the first and second groups in advance. Serum estradiol level; pregnancy rate; miscarriage rate, ovarian hyperstimulation syndrome (OHSS) and multiple pregnancy rate were compared among the three groups.


RESULTS
The pregnancy rate in FSH group, FSH + GnRH group and IVF-ET group were 37%, 54% and 22% respectively. The highest rate and multiple pregnancy rate was found in IVF-ET group.


CONCLUSIONS
The rationale treatment options for CC-resistant PCOS related infertility was the addition pre-suppressive treatment, low-dose FSH stimulated regimen subsequent pulsatile GnRH infusion. IVF were only accepted after failure with gonadotropin therapy.
Liang
X
X
First Affiliated Hospital of Sun Yat-Sen University of Medical Sciences, Guangzhou 510080, China.
Zhuang
G
G
Zhou
C
C
D000328:Adult; D000858:Anovulation / Q000209:etiology / Q000628:therapy*; D002996:Clomiphene / Q000494:pharmacology; D003131:Combined Modality Therapy; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology / Q000627:therapeutic use*; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000628:therapy*
D005300:Fertility Agents, Female; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone