Monoclonal antibody strategies to block angiogenesis.
Antibodies represent a unique class of therapeutics because of their high specificity towards a defined target antigen. Recent clinical success with antibody-based cancer therapeutics has led to an increase in the clinical development of these agents. Antibody therapeutics offer a promising approach for inhibiting new blood vessel formation (angiogenesis), which is associated with a variety of diseases, including cancer. In this review we will focus on angiogenesis-related mechanisms targeted by antibody-based therapeutics, with an emphasis on those studies where pre-clinical in vivo data is available.
Hicklin
D J.
DJ
ImClone Systems, 180 Varick Street, 10014, New York, NY, USA
Witte
L
L
Zhu
Z
Z
Liao
F
F
Wu
Y
Y
Li
Y
Y
Bohlen
P
P