Substance p.
This article provides a brief overview of the history of substance P from its discovery in the 1930s to the present day. The development of substance P receptor agonists and antagonists, and more recently the employment of transgenic mice, provide a framework to explore the functional role of substance P. Chronic inflammation and pain are associated with a number of diseases, and it has been proposed that substance P, released from primary afferent nerve endings play a role in these conditions. Recent developments with substance P antagonists have demonstrated the importance of substance P in several models of disease that span from asthma to chronic bronchitis; from cystitis, inflammatory bowel disease to migraine; emesis, depression, pain and seizures. Advancements in the knowledge of the role of substance P, its agonists and antagonists could provide clinical solutions for a variety of chronic inflammatory conditions.
Harrison
S
S
Department of Experimental and Clinical Medicine, Section of Pharmacology, University of Ferrara, Via Fossato Di Mortara 19, 44100, Ferrara, Italy. selena.harrison@dns.unife.it
Geppetti
P
P
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D064729:Neurokinin-1 Receptor Antagonists; D018040:Receptors, Neurokinin-1 / Q000819:agonists; D018039:Receptors, Tachykinin / Q000378:metabolism; D013373:Substance P / Q000096:biosynthesis / Q000378:metabolism*
D064729:Neurokinin-1 Receptor Antagonists; D018040:Receptors, Neurokinin-1; D018039:Receptors, Tachykinin; D013373:Substance P