[Significance of hypercoagulation index in treatment of allergic purpura by Huoxue Huayu decoction].
OBJECTIVE
To explore the therapeutic mechanism of Huoxue Huayu Decoction (HXHYD) in treating allergic purpura (AP) and the significance of hypercoagulation index (HCI).


METHODS
Patients of AP were divided into two groups. On the basis of conventional treatment of western medicine, the HXHYD was given to the treated group additionally, and the cure rate, change of hypercoagulation index of patients were compared with those of the control group treated by western conventional treatment alone.


RESULTS
The cure rate of the treated group was 86%, higher than that of control group (48%) significantly. HCI of the treated group was lowered markedly after treatment, as compared with that before treatment, the difference was significant (P < 0.01).


CONCLUSIONS
By the comprehensive effect of promoting anticoagulation activity, maintaining the integrity of vascular endothelia and reducing aggregation of platelets, HXHYD could reduce the HCI and improve hypercoagulative state of AP patients, so as to elevate the cure rate significantly.
Zhu
J
J
Affiliated Hospital of Nantong Medical College, Jiangsu(226001).
Zhu
J
J
Wang
T
T
D000293:Adolescent; D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D001777:Blood Coagulation; D002648:Child; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D014841:von Willebrand Factor / Q000378:metabolism*
D004365:Drugs, Chinese Herbal; D010975:Platelet Aggregation Inhibitors; D014841:von Willebrand Factor; D000990:Antithrombin III