title: Successful treatment of recurrent vulvar intraepithelial neoplasia resistant to interferon and isotretinoin with cidofovir.
abstract: Vulvar intraepithelial neoplasias are difficult to eradicate completely without extensive surgical intervention. Cidofovir, a deoxycytidine monophosphate analog, may have a therapeutic role in this disease. A 43-year-old woman with a 20-year history of genital warts presented with extensive vulvar intraepithelial neoplasia III, and refused surgical resection. Topical cidofovir 1% in Beeler base completely eradicated the lesion. Successive treatment applications, however, were necessary. Cidofovir is a promising topical antiviral compound for HPV induced vulvar intraepithelial neoplasia.
authors.affiliation: Gynecologic Oncology Unit, National Cancer Institute, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Koonsaeng
authors.forename: C
authors.initials: C
authors.lastname: Verschraegen
authors.forename: R
authors.initials: R
authors.lastname: Freedman
authors.forename: M
authors.initials: M
authors.lastname: Bossens
authors.forename: A
authors.initials: A
authors.lastname: Kudelka
authors.forename: J
authors.initials: J
authors.lastname: Kavanagh
authors.forename: T
authors.initials: T
authors.lastname: Sittisomwong
authors.forename: E
authors.initials: E
authors.lastname: DeClercq
authors.forename: R
authors.initials: R
authors.lastname: Snoeck
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002278:Carcinoma in Situ / Q000188:drug therapy*; D000077404:Cidofovir; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D007279:Injections, Subcutaneous; D007372:Interferons / Q000627:therapeutic use; D015474:Isotretinoin / Q000627:therapeutic use; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D014846:Vulvar Neoplasms / Q000188:drug therapy*; D002578:Uterine Cervical Dysplasia / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D007372:Interferons; D015474:Isotretinoin; D000077404:Cidofovir