Microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide.
In the present study, a new microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide technique has been developed. The results show that microwave irradiation can dehydrate penicillin G sulfoxide from a water content of 14-26 to below 0.5% in 40-60 min in N2 or air. After washing with ethyl acetate to remove impurities and residual water, the penicillin G sulfoxide can be used to synthesize cephalosporanic acid. The recovery of cephalosporanic acid was equal to and the purity of cephalosporanic acid was higher by 2% than that of the current dehydration technique. FTIR spectroscopy was used to study the process of microwave-enhanced dehydration and solvent washing purification of penicillin G sulfoxide.
Pan
X
X
Young Scientist Laboratory of Separation Science and Engineering, State Key Laboratory of Biochemical Engineering, Institute of Chemical Metallurgy, Chinese Academy of Sciences, 100080, Beijing, People's Republic of China.
Liu
H
H
An
Z
Z
Wang
J
J
Niu
G
G
D002626:Chemistry, Pharmaceutical / Q000379:methods*; D002851:Chromatography, High Pressure Liquid; D008872:Microwaves; D010400:Penicillin G / Q000031:analogs & derivatives* / Q000302:isolation & purification*; D017550:Spectroscopy, Fourier Transform Infrared
C059126:penicillin G sulfoxide; D010400:Penicillin G