title: [ICG angiography and retinal pigment epithelial decompensation (CRSC and epitheliopathy)].
abstract: OBJECTIVE
  To evaluate the prognosis of chronic central serous chorioretinopathy (CSC) and to assess whether certain clinical and angiographic features are associated with increased risk of vision loss.
  
  
  METHODS
  All of the 51 patients with chronic CSC, who had received a baseline evaluation with fluorescein angiography (FA) and indocyanine green angiography (ICGA), during the last 5 years were retrospectively included in the study.
  
  
  RESULTS
  The mean age was 49 years (range: 28-77 years). Sixteen out of 102 eyes (15.7%) of 14 patients lost at least 3 lines (0.3logMAR) after a mean follow-up of 34.7 months (range: 12-72 months). Logistic regression showed that CSC onset more than 7 years before inclusion (odds ratio: 4.3, p=0.024) and having areas of confluent RPE atrophy with FA at baseline (at least 2 disc diameters, odds ratio: 4.9,p=0.020) were independently associated with vision loss. Choroidal neovascularization was observed during follow-up in 4 eyes of 3 patients.
  
  
  CONCLUSIONS
  Disease duration of more than 7 years and the presence of confluent RPE atrophy independently characterized CSC patients at higher risk for visual loss in our series.
authors.affiliation: Clinique Ophtalmologique Université de Udine, V. le Venezia 410, Udine, 33100, Italie.
authors.forename: F
authors.initials: F
authors.lastname: Bandello
authors.forename: G
authors.initials: G
authors.lastname: Virgili
authors.forename: P
authors.initials: P
authors.lastname: Lanzetta
authors.forename: A
authors.initials: A
authors.lastname: Pirracchio
authors.forename: U
authors.initials: U
authors.lastname: Menchini
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography / Q000379:methods; D015862:Choroid Diseases / Q000000981:diagnostic imaging*; D002908:Chronic Disease; D004396:Coloring Agents; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008297:Male; D008875:Middle Aged; D010857:Pigment Epithelium of Eye; D012164:Retinal Diseases / Q000000981:diagnostic imaging*; D012189:Retrospective Studies
chemical_list: D004396:Coloring Agents; D007208:Indocyanine Green