title: Synthesis of a sulfahydantoin library.
abstract: A five-step solid-phase synthesis of sulfahydantoins from alpha-amino acids and aldehydes was developed. The synthetic method allows the use of hindered amino acids, including Val, Phg, and Aib, and use of aromatic aldehydes substituted with electron-withdrawing and -donating groups. Some limitations were encountered with amino acids with reactive side chains. A small but diverse library of compounds was produced for biological testing.
authors.affiliation: Department of Organic Chemistry, University of Barcelona, 08028-Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Albericio
authors.forename: L M
authors.initials: LM
authors.lastname: Bryman
authors.forename: J
authors.initials: J
authors.lastname: Garcia
authors.forename: E L
authors.initials: EL
authors.lastname: Michelotti
authors.forename: E
authors.initials: E
authors.lastname: Nicolás
authors.forename: C M
authors.initials: CM
authors.lastname: Tice
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D000596:Amino Acids / Q000737:chemistry*; D020650:Combinatorial Chemistry Techniques; D006827:Hydantoins / Q000138:chemical synthesis*; D015394:Molecular Structure; D013056:Spectrophotometry, Ultraviolet; D013457:Sulfur Compounds / Q000138:chemical synthesis*; D013844:Thiazoles / Q000737:chemistry*
chemical_list: D000447:Aldehydes; D000596:Amino Acids; D006827:Hydantoins; D013457:Sulfur Compounds; D013844:Thiazoles