title: The peritrophic matrix of hematophagous insects.
abstract: The peritrophic matrix (PM) is an extracellular envelope that lines the digestive tract of most insects. It is thought to play key roles in protecting insects from pathogens and facilitating digestion. Until recently, little information was available on the molecular composition of the PM. This review summarizes recent progress in the study of the PM from hematophagous insects, with emphasis on molecular and physiological aspects. Topics discussed include the presence of chitin and protein diversity in the PM, cloning and characterization of genes encoding PM proteins, PM permeability, and the role of the PM as a barrier for pathogens.
authors.affiliation: Department of Genetics, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4955, USA.
authors.forename: L
authors.initials: L
authors.lastname: Shao
authors.forename: M
authors.initials: M
authors.lastname: Devenport
authors.forename: M
authors.initials: M
authors.lastname: Jacobs-Lorena
mesh_terms: D000818:Animals; D002686:Chitin / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D007313:Insecta / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
chemical_list: D019476:Insect Proteins; D002686:Chitin