title: Novel cytotoxic 4-phenylfuranocoumarins from Calophyllum dispar.
abstract: Eight new 4-phenylfuranocoumarins (1-8) have been isolated from the stem bark and the fruits of Calophyllum dispar, together with three known coumarins. The structures of 1-8 were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these furanocoumarins exhibited significant cytotoxic activity against KB cells.
authors.affiliation: SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, F-49100 Angers, France.
authors.forename: D
authors.initials: D
authors.lastname: Guilet
authors.forename: J J
authors.initials: JJ
authors.lastname: Hélesbeux
authors.forename: D
authors.initials: D
authors.lastname: Séraphin
authors.forename: T
authors.initials: T
authors.lastname: Sévenet
authors.forename: P
authors.initials: P
authors.lastname: Richomme
authors.forename: J
authors.initials: J
authors.lastname: Bruneton
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007624:KB Cells; D013058:Mass Spectrometry; D019441:Plant Epidermis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins