Current perspective on the role of apoptosis in atherothrombotic disease.
Thrombus formation on a disrupted atherosclerotic plaque is a threatening event that leads to vessel occlusion and acute ischemia. In this current perspective, we present evidence for apoptosis as a major determinant of the thrombogenicity of the plaque lipid core and a potential contributor to plaque erosion and associated thrombosis. Moreover, apoptosis may directly affect blood thrombogenicity through the release of apoptotic cells and microparticles into the bloodstream.
Mallat
Z
Z
Institut Fédératif de Recherche "Circulation Paris VII " and INSERM U541, Hôpital Lariboisière, Paris, France.
Tedgui
A
A
D000789:Angina, Unstable / Q000209:etiology; D000818:Animals; D017209:Apoptosis; D001161:Arteriosclerosis / Q000150:complications / Q000378:metabolism*; D001777:Blood Coagulation / Q000502:physiology; D004617:Embolism / Q000209:etiology; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D009203:Myocardial Infarction / Q000209:etiology; D010718:Phosphatidylserines / Q000378:metabolism; D020521:Stroke / Q000209:etiology; D013925:Thromboplastin / Q000378:metabolism; D013927:Thrombosis / Q000150:complications / Q000378:metabolism*
D010718:Phosphatidylserines; D013925:Thromboplastin