title: Prevalence of functional dyspepsia and its relationship with Helicobacter pylori infection in a Japanese population.
abstract: OBJECTIVE
  To investigate the prevalence of functional dyspepsia and Helicobacter pylori infection and their relationship in a Japanese population.
  
  
  METHODS
  Two thousand five hundred people who visited Shimane Institute of Health Science for their annual medical check-up from September 1998 to August 1999 were prospectively enrolled in the study. After routine medical examination, including an upper gastrointestinal study and an ultrasonographic examination, all subjects were asked standard questions to check for the presence of any symptoms that suggested dyspepsia. Helicobacter pylori infection was determined by using a serum IgG antibody concentration with an ELISA.
  
  
  RESULTS
  Of the 2,500 persons investigated, 2,263 showed no abnormal finding in any medical examination. The presence or absence of symptoms and H. pylori infection was investigated in these 2,263 cases. Of these, 201 people (8.9%) experienced nausea, fullness and/or early satiety and were diagnosed as having dysmotility-like dyspepsia, while 118 people (5.2%) experienced pain localized to the epigastrium and were diagnosed as having ulcer-like dyspepsia. The frequency of these symptoms had a tendency to decline with age, although this was not statistically significant. In contrast, the rate of H. pylori infection increased with age. There was no significant relationship between H. pylori infection and any type of functional dyspepsia.
  
  
  CONCLUSIONS
  Helicobacter pylori infection does not influence the prevalence of the dysmotility-like and ulcer-like dyspeptic symptoms.
authors.affiliation: Department of Internal Medicine II, Shimane Medical University, Izumo, Japan. kadachi@shimane-med.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Kawamura
authors.forename: K
authors.initials: K
authors.lastname: Adachi
authors.forename: T
authors.initials: T
authors.lastname: Takashima
authors.forename: M
authors.initials: M
authors.lastname: Murao
authors.forename: T
authors.initials: T
authors.lastname: Katsube
authors.forename: M
authors.initials: M
authors.lastname: Yuki
authors.forename: M
authors.initials: M
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Kinoshita
mesh_terms: D000328:Adult; D004415:Dyspepsia / Q000453:epidemiology* / Q000382:microbiology* / Q000503:physiopathology; D005006:Ethnicity / Q000706:statistics & numerical data*; D005260:Female; D005767:Gastrointestinal Diseases / Q000382:microbiology; D005769:Gastrointestinal Motility; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori / Q000502:physiology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D013276:Stomach Ulcer / Q000382:microbiology