title: Detection of EBV DNA in the cord blood donor for a patient developing Epstein-Barr virus-associated lymphoproliferative disorder following mismatched unrelated umbilical cord blood transplantation.
abstract: Epstein-Barr virus-associated post-transplant lymphoproliferative disorder (PTLD) has been well described as a complication following allogeneic stem cell transplantation but has only recently been reported following umbilical cord blood (UCB) transplant. We report the case of a child transplanted with unrelated mismatched UCB for juvenile chronic myelogenous leukemia (JCML) who developed EBV-associated PTLD, which was confirmed pathologically, 139 days following stem cell infusion. There was no clinical response to reduction of immune suppression, high-dose acyclovir, or alpha interferon. The patient died 160 days after transplantation. EBV was detected by polymerase chain reaction in the cord blood unit used for transplantation. This case demonstrates that EBV-associated PTLD can occur following mismatched unrelated UCB transplant and may be related to transmission of EBV infection by donor lymphocytes.
authors.affiliation: Division of Hematology/Oncology, Department of Pediatrics, Northwestern University Medical School, Children's Memorial Hospital, 2300 Children's Plaza, Chicago, IL 60614, USA.
authors.forename: P R
authors.initials: PR
authors.lastname: Haut
authors.forename: P
authors.initials: P
authors.lastname: Kovarik
authors.forename: P H
authors.initials: PH
authors.lastname: Shaw
authors.forename: D
authors.initials: D
authors.lastname: Walterhouse
authors.forename: H B
authors.initials: HB
authors.lastname: Jenson
authors.forename: M
authors.initials: M
authors.lastname: Kletzel
mesh_terms: D001402:B-Lymphocytes / Q000473:pathology; D001782:Blood Donors; D002675:Child, Preschool; D004279:DNA, Viral / Q000097:blood; D020031:Epstein-Barr Virus Infections / Q000635:transmission*; D017809:Fatal Outcome; D005312:Fetal Blood / Q000166:cytology* / Q000821:virology*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D004854:Herpesvirus 4, Human / Q000235:genetics; D006648:Histocompatibility; D006650:Histocompatibility Testing; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000209:etiology / Q000276:immunology / Q000821:virology*; D008297:Male
chemical_list: D004279:DNA, Viral