title: Latex symptoms and sensitisation in health care workers.
abstract: BACKGROUND
  Natural rubber latex has become an important occupational health concern, particularly among health care workers, who for protection are required to wear latex gloves when at work. This study evaluated the prevalence of latex-related symptoms and sensitisation among a large group of health care workers in Trieste hospitals.
  
  
  METHODS
  We evaluated the prevalence of latex-related symptoms in 1,165 health care workers, by means of a questionnaire, a medical examination, skin prick tests and IgE-specific evaluation. We determined atopy and latex sensitivity by skin prick tests using a battery of common inhalant allergens, a commercial latex extract (Lofarma Allergeni, Milan) and individual skin puncture tests for each of the vegetables immunologically related to latex (potato, tomato, chestnut, banana, kiwi fruit). Associations between potential risk factors for latex allergy were assessed.
  
  
  RESULTS
  Glove-related symptoms were noticed on 17.2% of the nurses (200) the majority of symptoms being mild dermatitis with itching and erythema (120 subjects, 11.1%). Symptoms suggestive of IgE-mediated latex allergy were found in 51 subjects: 35 (3%) complained of contact urticaria and 16 (2.2%) complained of asthma and/or rhinitis. The resulting symptoms were significantly related to skin prick tests that were positive to latex (odds ratio (OR) = 11.89; 6.40-22.2), to personal atopy (OR = 2.15; 1.47-3.12), to familiar atopy (OR = 2.12; 1.48-3.03), to skin prick test positivity to related fruit (OR = 2.01; 1.16-3.46) but not to prick test positivity to common inhalant allergens (OR = 1.00; 0.71-1.39). Symptoms increased as a direct function of the time-usage of latex gloves and were more prevalent in operating room staff.
  
  
  CONCLUSIONS
  In this large cross-sectional study, glove-related symptoms and latex skin sensitisation appear to be substantial among health care workers, and are related to common signs of atopy. We stress the need of preventive measures to avoid latex exposure when health care workers are at risk of developing allergy symptoms.
authors.affiliation: Istituto di Medicina del Lavoro, Università degli Studi di Trieste, Via della Pietà 19, 34129 Trieste, Italy. Larese@univ.trieste.it
authors.forename: F
authors.initials: F
authors.lastname: Larese Filon
authors.forename: A
authors.initials: A
authors.lastname: Bosco
authors.forename: A
authors.initials: A
authors.lastname: Fiorito
authors.forename: C
authors.initials: C
authors.lastname: Negro
authors.forename: P
authors.initials: P
authors.lastname: Barbina
mesh_terms: D000328:Adult; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D005260:Female; D005932:Gloves, Surgical; D006282:Health Personnel; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007558:Italy / Q000453:epidemiology; D020315:Latex Hypersensitivity / Q000175:diagnosis / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000175:diagnosis / Q000453:epidemiology*; D016017:Odds Ratio; D015995:Prevalence; D012882:Skin Tests; D011795:Surveys and Questionnaires
chemical_list: D007073:Immunoglobulin E