The immunosuppressant LF-150195 inhibits the progression of established collagen-induced arthritis by blockage of anticollagen IgG2a production.
Ducoroy
P
P
Laboratoires Fournier SA, Immunologie, Daix, France. p.ducoroy@fournier.fr
de Fornel
D
D
Chirade
F
F
Fontet
P
P
Dutartre
P
P
D000704:Analysis of Variance; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001169:Arthritis, Experimental / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control*; D002417:Cattle; D003094:Collagen / Q000276:immunology*; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D006146:Guanidines / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood*; D007130:Immunoglobulin Idiotypes / Q000096:biosynthesis / Q000097:blood; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D013997:Time Factors
D006146:Guanidines; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007166:Immunosuppressive Agents; C434185:LF 150195; D003094:Collagen