title: Pulsed carbon dioxide and long pulse 10-ms erbium-YAG laser resurfacing: a comparative clinical and histologic study.
abstract: BACKGROUND
  The recent introduction of pulsed erbium-YAG laser technology has been accompanied by relatively few clinical studies with widely varying claims regarding postoperative healing, clinical side-effects and efficacy. We evaluated a new long (10 ms) pulsed erbium-YAG laser in order to determine safety and clinical efficacy in comparison with a pulsed carbon dioxide laser.
  
  
  OBJECTIVE
  Our objective was to comparatively evaluate a pulsed CO2 and long-pulsed erbium-YAG laser with regard to clinical side-effects, postoperative healing and efficacy in the reduction of rhytids.
  
  
  METHODS
  Bilateral periocular or perioral sites were treated using a pulsed CO2 (UltraPulse) laser on one side and long-pulsed erbium-YAG laser (CO3) on the opposite side. Histologic specimens were also studied in order to compare tissue effects of both lasers.
  
  
  RESULTS
  Results showed equivalent postoperative healing and lack of complications. In addition, the long-pulsed erbium-YAG laser showed significant efficacy in the treatment of mild and moderate rhytids.
  
  
  CONCLUSIONS
  The long-pulsed (10 ms) erbium-YAG laser appears to be of significant benefit in the treatment of facial rhytids. Tissue studies show a greater degree of thermal damage in the dermis when compared to traditional 350 microseconds erbium-YAG lasers which may underlie the beneficial effects of this laser in the treatment of aging skin.
authors.affiliation: Georgetown University Medical School, Center for Laser Surgery, Washington, DC, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Adrian
mesh_terms: D000328:Adult; D000368:Aged; D002245:Carbon Dioxide; D004871:Erbium; D005260:Female; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D015361:Rhytidoplasty / Q000295:instrumentation / Q000379:methods*; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide; D004871:Erbium