title: Bilateral infiltrating lobular carcinoma of the breast with osteoclast-like giant cells.
abstract: A case of bilateral infiltrating lobular carcinoma of the breast containing osteoclast-like giant cells is presented. Notable pathologic features include prominent tumor-associated angiogenesis and the presence of osteoclast-like giant cells in axillary lymph node metastases. Immunohistologic and ultrastructural examination support a nonepithelial, histiocytic origin for the giant cells, and results are similar to previous reports of osteoclast-like giant cells associated with breast carcinoma. This is the first report of bilateral pure infiltrating lobular carcinoma of the breast with osteoclast-like giant cells and the first case of pure lobular carcinoma with osteoclast-like giant cells present in lymph node metastases.
authors.affiliation: Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill, USA.
authors.forename: M V
authors.initials: MV
authors.lastname: Iacocca
authors.forename: D M
authors.initials: DM
authors.lastname: Maia
mesh_terms: D001365:Axilla; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000473:pathology* / Q000601:surgery; D018270:Carcinoma, Ductal, Breast / Q000473:pathology* / Q000556:secondary / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D015726:Giant Cells / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008327:Mammography; D015411:Mastectomy, Modified Radical / Q000379:methods; D008854:Microscopy, Electron; D008875:Middle Aged; D010010:Osteoclasts / Q000473:pathology / Q000648:ultrastructure