Genetic polymorphism of CYP2D6 in Karnataka and Andhra Pradesh population in India.
OBJECTIVE
To study the prevalence of cytochrome P-450 2D6 (CYP2D6) polymorphism in Karnataka (KA) and Andhra Pradesh (AP) population.


METHODS
Two hundred and eleven healthy human volunteers participated in the study (100 from KA and 111 from AP). At bed time, after voiding their bladder, the volunteers ingested 30 mg of dextromethorphan hydrobromide (DM). Urine samples were collected for 8 h. DM and its metabolite dextrorphan (DT) were estimated in the urine using HPLC. The metabolic ratio (DM/DT) was used for phenotyping.


RESULTS
The prevalence of poor metabolisers (PM) in KA is 4% and AP is 1.8%.


CONCLUSIONS
The frequency of PM phenotype in South Indian population is in between the Western and Oriental population.
Abraham
B K
BK
Clinical Pharmacology Unit, Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry-605 006, India.
Adithan
C
C
Kiran
P U
PU
Asad
M
M
Koumaravelou
K
K
D000293:Adolescent; D000328:Adult; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003915:Dextromethorphan / Q000378:metabolism; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic
D003915:Dextromethorphan; D019389:Cytochrome P-450 CYP2D6