title: Structure-based design of non-peptide HIV protease inhibitors.
abstract: A number of structurally novel P2-ligands have been designed and synthesized. Incorporation of these ligands in the (R)-(hydroxyethyl)sulfonamide isostere provided a series of potent non-peptidyl HIV protease inhibitors.
authors.affiliation: Department of Chemistry, University of Illinois at Chicago, IL 60607, USA. arunghos@uic.edu
authors.forename: A K
authors.initials: AK
authors.lastname: Ghosh
authors.forename: D
authors.initials: D
authors.lastname: Shin
authors.forename: L
authors.initials: L
authors.lastname: Swanson
authors.forename: K
authors.initials: K
authors.lastname: Krishnan
authors.forename: H
authors.initials: H
authors.lastname: Cho
authors.forename: K A
authors.initials: KA
authors.lastname: Hussain
authors.forename: D E
authors.initials: DE
authors.lastname: Walters
authors.forename: L
authors.initials: L
authors.lastname: Holland
authors.forename: J
authors.initials: J
authors.lastname: Buthod
mesh_terms: D015195:Drug Design; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D017320:HIV Protease Inhibitors