New approach in drug development: whole blood pharmacodynamic assays reflect biological activities of tacrolimus.
Klupp
J
J
Department of Cardiothoracic Surgery, Transplantation Immunology, Stanford Medical School, Stanford, California, USA
Dambrin
C
C
Regieli
J
J
van Gelder
T
T
Shorthouse
R
R
Morris
R E
RE
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D002478:Cells, Cultured; D015195:Drug Design; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008252:Macaca fascicularis; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*; D016559:Tacrolimus / Q000097:blood* / Q000493:pharmacokinetics / Q000494:pharmacology*
D000945:Antigens, Differentiation, T-Lymphocyte; D007166:Immunosuppressive Agents; D016559:Tacrolimus