title: [Malignant solitary fibrous tumor of pleura with focal expression of cytokeratin].
abstract: Solitary fibrous tumor is a rare circumscribed neoplasm involving usually the pleura and now described in many organs and in the soft tissues with a favorable outcome when completely excised. We report herein a malignant solitary fibrous tumor of the pleura occurring in a 59-year-old woman. The tumor cells strongly expressed vimentin and CD 34. In addition a weak positive staining was obtained using CD 99 and bcl 2. A disconcerting focal immunoreactivity with cytokeratin was observed. Solitary fibrous tumor is composed of loosely arranged spindle cells of variable density and may occasionally mimic malignant mesothelioma, an hemangiopericytoma or synovial sarcoma. Immunohistochemical study is helpful demonstrating a strong positivity for vimentin and CD 34 and absence of staining for epithelial markers and S-100 protein.
authors.affiliation: Service d'Anatomie et de Cytologie Pathologiques, CHRU, 59045 Lille cedex. x-leroy@chru-lille.fr
authors.forename: X
authors.initials: X
authors.lastname: Leroy
authors.forename: M C
authors.initials: MC
authors.lastname: Copin
authors.forename: S
authors.initials: S
authors.lastname: Petit
authors.forename: D
authors.initials: D
authors.lastname: Moukassa
authors.forename: B
authors.initials: B
authors.lastname: Gosselin
mesh_terms: D000071443:12E7 Antigen; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34 / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis*; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000737:chemistry / Q000175:diagnosis* / Q000473:pathology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D000071443:12E7 Antigen; D015703:Antigens, CD; D018952:Antigens, CD34; C061828:CD99 protein, human; D015815:Cell Adhesion Molecules; D019253:Proto-Oncogene Proteins c-bcl-2; D014746:Vimentin; D007633:Keratins