Biochemical characterization of human DNA polymerase iota provides clues to its biological function.
The human RAD30B gene has recently been shown to encode a novel DNA polymerase, DNA polymerase iota (poliota). The role of poliota within the cell is presently unknown, and the only clues to its cellular function come from its biochemical characterization in vitro. The aim of this short review is, therefore, to summarize the known enzymic activities of poliota and to speculate as to how these biochemical properties might relate to its in vivo function.
Tissier
A
A
Section on DNA Replication, Repair, and Mutagenesis, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-2725, U.S.A.
Frank
E G
EG
McDonald
J P
JP
Vaisman
A
A
Fernàndez de Henestrosa
A R
AR
Boudsocq
F
F
McLenigan
M P
MP
Woodgate
R
R
D020137:Base Pair Mismatch / Q000235:genetics; D001483:Base Sequence; D004249:DNA Damage / Q000235:genetics; D004256:DNA Polymerase I / Q000378:metabolism; D004260:DNA Repair / Q000235:genetics; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D000094769:DNA Polymerase iota
D004256:DNA Polymerase I; D004259:DNA-Directed DNA Polymerase; D000094769:DNA Polymerase iota; C000722070:POLI protein, human