title: [Mature time demarcation of human immature myocardium].
abstract: OBJECTIVE
  To study the mature time demarcation of human immature myocardium.
  
  
  METHODS
  The morpho-ultrastructure, calcium metabolism, energy metabolism and oxygen free radicals metabolism of myocardium of children with ventricular septal defect without pulmonary hypertension or any clinical symptoms were studied at different ages.
  
  
  RESULTS
  The immature myocardium possessed its own structure and functional characteristics. Before viripotent period, the age-related myocardial changes developed progressively to mature and almost approached to mature levels at 6-9 years old. The indices of immature myocardium developing to mature levels were inconsistent.
  
  
  CONCLUSIONS
  The structure and function of human immature myocardium approaches to mature levels at 6-9 years old.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, First Affiliated Hospital of Hubei Medical University, Wuhan 430060, China.
authors.forename: S
authors.initials: S
authors.lastname: Gao
authors.forename: Q
authors.initials: Q
authors.lastname: Geng
authors.forename: B
authors.initials: B
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D005260:Female; D006321:Heart / Q000254:growth & development*; D006343:Heart Septal Defects / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*