title: Metoprolol CR/XL in the treatment of chronic heart failure.
abstract: Metoprolol CR/XL (metoprolol succinate extended-release tablets) is a beta1-selective agent that improved survival and reduced hospitalization among patients with New York Heart Association class II-IV heart failure in a randomized trial. Metoprolol CR/XL differs from conventional metoprolol tartrate with respect to pharmacokinetic and pharmacodynamic properties that may be clinically important in patients with heart failure. A thorough patient evaluation should be performed to determine optimal dosage and titration of this drug, as with any beta-blocker, and to assess the potential for drug-drug or drug-disease interactions. By applying knowledge of drug-specific characteristics and designing therapy for each individual patient, improvement in patient outcomes can be realized with metoprolol CR/XL.
authors.affiliation: Duke University Medical Center, Durham, North Carolina 27705, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Gattis
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000592:standards; D006333:Heart Failure / Q000097:blood / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008790:Metoprolol / Q000031:analogs & derivatives / Q000627:therapeutic use*
chemical_list: D000319:Adrenergic beta-Antagonists; D008790:Metoprolol