title: Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.
abstract: The synthesis and in vitro characterization of A-119637 and A-123189, two novel, selective and potent alpha1D antagonists, are described.
authors.affiliation: Abbott Laboratories, Neurological and Urological Diseases Research, Abbott Park, IL 60064-6101, USA. william.a.carroll@abbott.com
authors.forename: W A
authors.initials: WA
authors.lastname: Carroll
authors.forename: K B
authors.initials: KB
authors.lastname: Sippy
authors.forename: T A
authors.initials: TA
authors.lastname: Esbenshade
authors.forename: S A
authors.initials: SA
authors.lastname: Buckner
authors.forename: A A
authors.initials: AA
authors.lastname: Hancock
authors.forename: M D
authors.initials: MD
authors.lastname: Meyer
mesh_terms: D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002417:Cattle; D003001:Cloning, Molecular; D006801:Humans; D066298:In Vitro Techniques; D008024:Ligands; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D019275:Radiopharmaceuticals; D051381:Rats; D013154:Spleen / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
chemical_list: C436344:A119637; C436343:A123189; D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D008024:Ligands; D010879:Piperazines; D011743:Pyrimidines; D019275:Radiopharmaceuticals