title: Engineering human chromosomes for gene therapy studies.
abstract: We now have the capability to engineer human chromosomes that could be used to deliver therapeutic genes in gene therapy studies. These vectors have the advantages of being non-disruptive to the genome, non-immunogenic and are capable of carrying very large genes with all their regulatory sequences. What challenges lie ahead, and what future does this technology hold for gene therapy?
authors.forename: K H
authors.initials: KH
authors.lastname: Choo
mesh_terms: D000818:Animals; D002875:Chromosomes / Q000648:ultrastructure*; D018014:Gene Transfer Techniques; D005818:Genetic Engineering; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends*; D005822:Genetic Vectors; D006801:Humans; D051379:Mice