5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors.
A novel series of 5,5-diaryl-2-amino-4-pentenoates was synthesized and found to be potent and selective glycine transporter type-2 reuptake inhibitors.
Isaac
M
M
NPS Pharmaceuticals Inc., 6850 Goreway Drive, L4V 1V7, Mississauga, ON, Canada. misaac@npsallelix.com
Slassi
A
A
Silva
K D
KD
Arora
J
J
MacLean
N
N
Hung
B
B
McCallum
K
K
D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D026921:Amino Acid Transport Systems, Neutral; D000963:Antimetabolites / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D050487:Glycine Plasma Membrane Transport Proteins; D013329:Structure-Activity Relationship
D000475:Alkenes; D026921:Amino Acid Transport Systems, Neutral; D000963:Antimetabolites; D002352:Carrier Proteins; D050487:Glycine Plasma Membrane Transport Proteins