title: Biodegradable p(DLLA-epsilon-CL) nerve guides versus autologous nerve grafts: electromyographic and video analysis.
abstract: The aim of this study was to evaluate the functional effects of bridging a gap in the sciatic nerve of the rat with either a biodegradable copolymer of DL-lactide and epsilon-caprolactone [p(DLLA-epsilon-CL)] nerve guide or an autologous nerve graft. Electromyograms (EMGs) of the gastrocnemius (GC) and tibialis anterior (TA) muscles were recorded 3.5 and 5 months after bridging the nerve gaps. Furthermore, the rats' gait was recorded on video and the quality of the gait was analyzed. EMG patterns of the contralateral nonoperated side were essentially normal. The EMG patterns on the operated side were irregular in all animals, but the quality of gait was better in the nerve guide group. We conclude that the surgical technique (nerve guide or nerve graft) does not influence the occurrence of abnormal EMG patterns, but gait improves to a greater extent when the nerve gap is bridged by a nerve guide.
authors.affiliation: Department of Plastic Surgery, University Hospital Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands. marcelfmeek@hotmail.com
authors.forename: M F
authors.initials: MF
authors.lastname: Meek
authors.forename: J F
authors.initials: JF
authors.lastname: Van Der Werff
authors.forename: J P
authors.initials: JP
authors.lastname: Nicolai
authors.forename: A
authors.initials: A
authors.lastname: Gramsbergen
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D004576:Electromyography; D007839:Functional Laterality; D005684:Gait / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology*; D011091:Polyesters; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000502:physiology* / Q000601:surgery; D013997:Time Factors; D014182:Transplantation, Autologous; D014741:Video Recording; D016138:Walking
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C062968:lactide-caprolactone copolymer