Pulmonary epithelial-myoepithelial tumor of unproven malignant potential: report of a case and review of the literature.
Epithelial-myoepithelial tumors of the lung are rare neoplasms whose biological behavior and clinical course still remain to be defined. A case of epithelial-myoepithelial tumor of the lung arising from bronchial mucosa-submucosa and occurring as a polypoid lesion of the upper left bronchus in a 47-year-old man is reported. The tumor did not infiltrate the cartilaginous wall of the bronchus and showed a biphasic histological appearance with a double layering of epithelial and myoepithelial cells. Myoepithelial spindle cells with eosinophilic cytoplasm were also observed. Mitotic figures were very rare and necrosis absent. Immunohistochemical study for epithelial and muscular markers confirmed the presence of a double-cell component in the tumor, namely epithelial and myoepithelial. The patient is alive and well, with no evidence of recurrent or metastatic disease 6 months after surgery. On the basis of the present case and the six previously reported cases, we suggest using the noncommittal term pulmonary epithelial-myoepithelial tumor of unproven malignant potential (PEMTUMP) for this type of neoplasm. In addition, we first introduce p63 as a novel marker for highlighting the myoepithelial cells of the respiratory tract and speculate on the role of these cells in the development of this unusual tumor.
Pelosi
G
G
Department of Pathology and Laboratory Medicine, European Institute of Oncology and University of Milan School of Medicine, Italy. giuseppe.pelosi@ieo.it
Fraggetta
F
F
Maffini
F
F
Solli
P
P
Cavallon
A
A
Viale
G
G
D008949:Adenoma, Pleomorphic / Q000175:diagnosis; D014408:Biomarkers, Tumor / Q000032:analysis; D001984:Bronchial Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D002277:Carcinoma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D003528:Carcinoma, Adenoid Cystic / Q000175:diagnosis; D003937:Diagnosis, Differential; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008482:Mediastinum / Q000601:surgery; D008875:Middle Aged; D009208:Myoepithelioma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D009362:Neoplasm Metastasis / Q000175:diagnosis; D009363:Neoplasm Proteins / Q000032:analysis; D013902:Radiography, Thoracic; D003074:Solitary Pulmonary Nodule / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins