gp96-peptide vaccination of mice against intracellular bacteria.
This work demonstrates that gp96 preparations isolated from cells infected with intracellular bacteria induce cytotoxic T-lymphocyte responses and confer protection. Our findings extend previous reports on the immunogenicity of gp96-associated peptides to antigens derived from intracellular bacteria. Immunization with gp96 may therefore represent a promising vaccination strategy against bacterial pathogens.
Zügel
U
U
Department of Immunology, University of Ulm, Germany.
Sponaas
A M
AM
Neckermann
J
J
Schoel
B
B
Kaufmann
S H
SH
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D006360:Heat-Shock Proteins / Q000276:immunology* / Q000378:metabolism; D008089:Listeria monocytogenes / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism; D008088:Listeriosis / Q000517:prevention & control*; D051379:Mice; D008810:Mice, Inbred C57BL; D009169:Mycobacterium tuberculosis / Q000276:immunology; D010455:Peptides / Q000276:immunology* / Q000378:metabolism; D013154:Spleen / Q000382:microbiology; D014376:Tuberculosis / Q000517:prevention & control*; D014611:Vaccination
D006360:Heat-Shock Proteins; D010455:Peptides