Contribution of genetic variations in estradiol biosynthesis and metabolism enzymes to osteoporosis.
The occurrence of osteoporosis is closely related to serum estradiol level. CYP19 is the most important biosynthesis enzyme and CYP1A2, CYP3A4, and 17 beta-HSD are important metabolism enzymes. Any changes in these enzymes activity affects estradiol biosynthesis or metabolism, and changes the estradiol serum level. By reviewing the recent literature, it was found that the genetic variations of CYP19, CYP1A2, CYP3A4, and 17 beta-HSD are important factors affecting the estradiol serum level, and may be closely related to the development of osteoporosis.
Cheng
Z N
ZN
Pharmacogenetics Research Institute, Basic and Clinical Pharmacology Institute, Hunan Medical University, Changsha 410078, China.
Zhou
H H
HH
D000818:Animals; D001141:Aromatase / Q000235:genetics*; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004958:Estradiol / Q000096:biosynthesis* / Q000097:blood; D014644:Genetic Variation; D006801:Humans; D006913:Hydroxysteroid Dehydrogenases / Q000235:genetics*; D006899:Mixed Function Oxygenases / Q000235:genetics; D015663:Osteoporosis, Postmenopausal / Q000201:enzymology* / Q000235:genetics; D011110:Polymorphism, Genetic
D004958:Estradiol; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D006913:Hydroxysteroid Dehydrogenases; C035507:3(17)-hydroxysteroid dehydrogenase; D001141:Aromatase; C104464:CYP3A protein, human; D019388:Cytochrome P-450 CYP1A2; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human