Clear Cell Ovarian Carcinoma Following Long-Term Tamoxifen Use.
A case of clear cell ovarian cancer and endometriosis in a postmenopausal patient following adjuvant tamoxifen for breast cancer is presented. Immunohistochemistry demonstrated the tumor to be positive for progesterone receptor protein but not estrogen receptor protein; the endometriosis was positive for both proteins. Literature review reveals this to be the first report of both clear cell ovarian cancer and endometriosis following tamoxifen use, and the third report of epithelial ovarian cancer associated with tamoxifen.
Jennings
T. Scott
TS
Departments of Obstetrics and Gynecology and Pathology, Medical University of South Carolina, Charleston, South Carolina.
Haddad
Mary E.
ME
Smith
Timothy M.
TM