title: The hippurate ratio as an indicator of functional hepatic reserve for resection of hepatocellular carcinoma in cirrhotic patients.
abstract: Predicting the ability of the cirrhotic liver to withstand resection remains a challenge for the surgeon. This study evaluates the use of the hippurate ratio, a novel assessment of glycine conjugation of para-aminobenzoic acid by the liver, as a preoperative indicator of functional hepatic reserve. Between 1998 and 2000, sixty-one cirrhotic patients were prospectively assessed for hepatic resection using the hippurate ratio, indocyanine green retention at 15 minutes (ICG R-15), and other standard measures of liver function. Twenty-six patients were excluded as candidates for resection on the basis of inadequate functional hepatic reserve. Patients excluded from resection had significantly higher ICG R-15 values (29% +/- 9% vs. 16% +/- 12%, P = 0.001), higher Child-Pugh scores (5.9 +/- 0.9 vs. 5.3 +/- 0.4, P = 0.01), and lower hippurate ratios (30% +/- 14% vs. 45% +/- 15%, P = 0.005). There was a significant correlation between the hippurate ratio and ICG R-15. Other indicators of liver function such as factor V, factor VII, albumin, bilirubin, prothrombin time, and transaminases were no different between patients who did and those who did not undergo resection. Of the 35 patients resected, there were seven (20%) who developed varying degrees of liver failure with three perioperative deaths (8.5%). Patients who had some degree of liver failure had significantly lower hippurate ratios than patients who had no liver failure (29% +/- 10% vs. 48% +/- 14%, P = 0.002). There was no difference in ICG R-15 values between patients who had liver failure and those who did not. The hippurate ratio offers information on hepatocellular reserve that is not provided by other measures of liver function and may allow better selection of cirrhotic patients for liver resection.
authors.affiliation: Department of Surgery, University of Florida, Gainesville 32610, USA. hemmiaw@mail.surgery.ufl.edu
authors.forename: A W
authors.initials: AW
authors.lastname: Hemming
authors.forename: S
authors.initials: S
authors.lastname: Gallinger
authors.forename: P D
authors.initials: PD
authors.lastname: Greig
authors.forename: M S
authors.initials: MS
authors.lastname: Cattral
authors.forename: B
authors.initials: B
authors.lastname: Langer
authors.forename: B R
authors.initials: BR
authors.lastname: Taylor
authors.forename: Z
authors.initials: Z
authors.lastname: Verjee
authors.forename: E
authors.initials: E
authors.lastname: Giesbrecht
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamachi
authors.forename: K N
authors.initials: KN
authors.lastname: Furuya
mesh_terms: D010129:4-Aminobenzoic Acid / Q000378:metabolism*; D000328:Adult; D000368:Aged; D000618:Aminohippuric Acids; D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism* / Q000601:surgery; D004396:Coloring Agents; D005260:Female; D005998:Glycine / Q000378:metabolism; D006498:Hepatectomy / Q000009:adverse effects / Q000379:methods / Q000401:mortality; D006801:Humans; D007208:Indocyanine Green; D008103:Liver Cirrhosis / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D017093:Liver Failure / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D008111:Liver Function Tests / Q000379:methods* / Q000592:standards; D008113:Liver Neoplasms / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism* / Q000601:surgery; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011300:Preoperative Care / Q000379:methods* / Q000592:standards; D011446:Prospective Studies; D012720:Severity of Illness Index; D010130:p-Aminohippuric Acid / Q000097:blood*
chemical_list: D000618:Aminohippuric Acids; D004396:Coloring Agents; C024893:4-acetylaminohippuric acid; D007208:Indocyanine Green; D005998:Glycine; D010129:4-Aminobenzoic Acid; D010130:p-Aminohippuric Acid