A retro-inverso Prosaptide D5 promotes a myelination process in developing rats.
The myelinotrophic action of Prosaptide D5 was investigated in developing rats. Sulfatide concentrations in brain and sciatic nerve were determined to assess the development of myelination. Subcutaneous D5-injection significantly increased sulfatide concentrations in both brain and sciatic nerve by 250 and 150% over controls, respectively. D5 promoted ERK phosphorylation in iSC Schwann cells similar to prosaposin. The results showed that D5 treatment stimulated a myelination process in developing rat.
Hiraiwa
M
M
Department of Neurosciences, University of California at San Diego, School of Medicine, Center for Molecular Genetics, La Jolla, CA 92093-0634, USA. mhiraiwa@ucsd.edu
Campana
W M
WM
Wang
C Y
CY
Otero
D A
DA
O'Brien
J S
JS
D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D006128:Growth; D007279:Injections, Subcutaneous; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D009186:Myelin Sheath / Q000187:drug effects* / Q000502:physiology*; D009414:Nerve Growth Factors / Q000494:pharmacology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D009994:Osmolar Concentration; D010766:Phosphorylation / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012583:Schwann Cells / Q000187:drug effects / Q000378:metabolism; D012584:Sciatic Nerve / Q000187:drug effects / Q000378:metabolism; D013433:Sulfoglycosphingolipids / Q000378:metabolism
D009414:Nerve Growth Factors; D018696:Neuroprotective Agents; D013433:Sulfoglycosphingolipids; C404155:prosaptide D5; D020928:Mitogen-Activated Protein Kinases