title: Analogues of polyamine alkaloids and their synthetic advantages.
abstract: Several polyamine derivatives were synthesized in order to produce novel antagonists of muscular nicotinic acetylcholine receptors. Their affinities were compared with those of philanthotoxin PhTX-343.
authors.affiliation: Organisch-chemisches Institut, Universität Zürich, Switzerland.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: K
authors.initials: K
authors.lastname: Popaj
authors.forename: M
authors.initials: M
authors.lastname: Lochner
authors.forename: H
authors.initials: H
authors.lastname: Geneste
authors.forename: R
authors.initials: R
authors.lastname: Budriesi
authors.forename: A
authors.initials: A
authors.lastname: Chiarini
authors.forename: C
authors.initials: C
authors.lastname: Melchiorre
authors.forename: M
authors.initials: M
authors.lastname: Hesse
mesh_terms: D000818:Animals; D006801:Humans; D018733:Nicotinic Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D011073:Polyamines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D018733:Nicotinic Antagonists; D011073:Polyamines