Altered sensitivity of CD81-deficient mice to neurobehavioral effects of cocaine.
CD81, also known as target of the antiproliferative antibody, is known to be expressed in astrocytes and involved in cell adhesion and, recently, we demonstrated its induction exclusively in the accumbens following cocaine. In the present study, the sensitivity of CD81-deficient mice to behavioral effects of cocaine was evaluated. It was found that CD81-deficient mice exhibited altered sensitivity to cocaine as assessed in the place preference conditioning paradigm and locomotor activity. This deficit in place preference conditioning was not accompanied by a deficit in acquisition or retention of water maze behavior. In addition, CD81 knockout mice exhibited higher levels of nucleus accumbens dopamine as compared to their controls. These observations are discussed in the context of the role of CD81 in cocaine-mediated behaviors.
Michna
L
L
Department of Toxicology, Rutgers, The State University, New Brunswick, NJ 08854, USA.
Brenz Verca
M S
MS
Widmer
D A
DA
Chen
S
S
Lee
J
J
Rogove
J
J
Zhou
R
R
Tsitsikov
E
E
Miescher
G C
GC
Dreyer
J L
JL
Wagner
G C
GC
D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000502:physiology*; D003042:Cocaine / Q000633:toxicity*; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004351:Drug Resistance; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008565:Membrane Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D009043:Motor Activity / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000378:metabolism; D009714:Nucleus Accumbens / Q000378:metabolism; D013037:Spatial Behavior / Q000187:drug effects*; D060225:Tetraspanin 28
D015703:Antigens, CD; C554799:Cd81 protein, mouse; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D060225:Tetraspanin 28; D003042:Cocaine; D004298:Dopamine