Low-grade non-Hodgkin's lymphoma in a patient with systemic lupus erythematosus.
Coexistence of systemic lupus erythematosus (SLE) with low-grade non-Hodgkin's lymphoma (LGNHL) has been described occasionally in the literature with the potential pathogenetic role of monoclonal B CD5+/CD19+ cells. We report a case of LGNHL which developed 18 months after diagnosis of SLE. The monoclonal population of lymphocytes in the peripheral blood and bone marrow was CD5/CD19 negative but CD19/CD22 positive. The SLE responded well to treatment with prednisone and the course of the LGNHL was stable and cytotoxic treatment was not required.
Robak
T
T
Department of Hematology; Medical University of Lódź, Copernicus Memorial Hospital, Poland. robaktad@psk2.am.lodz.pl
Robak
E
E
Bartkowiak
J
J
Błoński
J Z
JZ
Niewiadomska
H
H
Wawrzyniak
E
E
D015703:Antigens, CD / Q000032:analysis; D018941:Antigens, CD19 / Q000032:analysis; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D001402:B-Lymphocytes / Q000737:chemistry / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D018956:CD5 Antigens / Q000032:analysis; D015815:Cell Adhesion Molecules; D002999:Clone Cells / Q000737:chemistry / Q000473:pathology; D005260:Female; D015321:Gene Rearrangement; D019676:Genes, T-Cell Receptor delta; D006801:Humans; D016130:Immunophenotyping; D037102:Lectins; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D051918:Sialic Acid Binding Ig-like Lectin 2; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000473:pathology
D015703:Antigens, CD; D018941:Antigens, CD19; D000944:Antigens, Differentiation, B-Lymphocyte; C497867:CD22 protein, human; D018956:CD5 Antigens; D015815:Cell Adhesion Molecules; D037102:Lectins; D051918:Sialic Acid Binding Ig-like Lectin 2