[Involvement of the IGF system in the pathogenesis of adrenocortical tumors].
Adrenocortical carcinoma remains a challenge for the therapeutist; prognosis is ominous. Various abnormalities playing a pathogenetic role have been recently described in adrenocortical tumors. Among them, dysregulation of the IGF system and imprinting mistakes at the 11p15 locus play a determining role in malignant transformation of adrenocortical cells. These markers of the malignant phenotype might markedly improve our diagnosis and prognosis abilities.
Gicquel
C
C
Laboratoire d'Explorations Fonctionnelles Endocriniennes, Hôpital Trousseau, 75012 Paris.
Boulle
N
N
Logié
A
A
Bourcigaux
N
N
Gaston
V
V
Le Bouc
Y
Y
D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D009154:Mutation; D013002:Somatomedins / Q000235:genetics* / Q000502:physiology
D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II