Ibuprofen effects on behavioral thermoregulation with microwave radiation in albino rats.
This study determined whether ibuprofen causes a disruptive behavior pattern similar to aspirin yet contrary to acetaminophen regarding thermoregulatory effects. 8 Sprague-Dawley rats (3 males and 5 females) were drawn from a population of rats which had been conditioned to press a lever for food reinforcement in an undergraduate course in operant conditioning. Animals were conditioned in a refrigerated Skinner Box on a fixed-interval 2-min. (FI-2 min.) schedule of microwave radiation (5 sec. of radiation per exposure occasion) in a repeated-measures reversal (within-subjects) design. The rats were injected intraperitoneally with doses of ibuprofen in amounts of 10-50 mg/kg or methyl-cellulose control vehicle of equal volume over 8-hr. daily sessions. A multivariate analysis of variance showed significant differences due to doses (mg/kg) of ibuprofen for number of microwave heat reinforcers per hour and rate of responding (ns) both measures of which were significantly higher during the first 2 hours of the session. Comparative differences in behavioral thermoregulation in humans reflect the likelihood of underlying biochemical mechanisms based on research by Murphy, Badia, Myers, Boecker, and Wright in 1994.
Vitulli
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WF
University of South Alabama, Mobile, USA.
Nemeth
Y M
YM
Conte
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CT
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001833:Body Temperature Regulation / Q000187:drug effects*; D005260:Female; D007052:Ibuprofen / Q000494:pharmacology*; D008297:Male; D008872:Microwaves; D051381:Rats; D017207:Rats, Sprague-Dawley
D018712:Analgesics, Non-Narcotic; D007052:Ibuprofen