Expression of interferon consensus sequence binding protein induces potent immunity against BCR/ABL-induced leukemia.
Mice deficient in the interferon consensus sequence binding protein (ICSBP) develop a disease resembling chronic myeloid leukemia (CML), which in humans is caused by the BCR/ABL oncoprotein. Interferon-alpha (IFN-alpha) induces ICSBP expression and is an effective therapy for CML. This study examined whether enforced expression of ICSBP might antagonize BCR/ABL-induced leukemia; results demonstrated that ICSBP-modified cells generated a protective CD8(+) cytotoxic T-cell response against BCR/ABL-transformed BaF3 cells in a murine leukemia model. ICSBP expression represents a novel means of stimulating a host immune response to BCR/ABL(+) leukemia cells and a potential strategy for immunotherapy of CML. (Blood. 2001;97:3491-3497)
Deng
M
M
Whitehead Institute, 9 Cambridge Center, Cambridge, MA 02142, USA.
Daley
G Q
GQ
D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D002471:Cell Transformation, Neoplastic; D005260:Female; D016044:Fusion Proteins, bcr-abl / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D015870:Gene Expression; D007109:Immunity; D007114:Immunization; D050835:Interferon Regulatory Factors; D007372:Interferons / Q000502:physiology; D007938:Leukemia / Q000276:immunology* / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D016688:Mice, Inbred NOD; D016513:Mice, SCID; D009368:Neoplasm Transplantation; D012097:Repressor Proteins / Q000235:genetics* / Q000502:physiology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013154:Spleen / Q000276:immunology; D014162:Transfection; D000099185:Interferon Regulatory Factor-8
D016044:Fusion Proteins, bcr-abl; D050835:Interferon Regulatory Factors; D007372:Interferons; D012097:Repressor Proteins; D000099185:Interferon Regulatory Factor-8