Ranitidine-related Stevens-Johnson syndrome in patients with severe liver diseases: a report of two cases.
Ranitidine is widely used and well tolerated. Ranitidine-related skin eruption is rare and usually mild. We presented two patients who developed Stevens-Johnson syndrome after ranitidine therapy. Before therapy, both patients had severe liver disease and jaundice. The first was a case of ketoconazole-induced hepatitis, and the second was a case of hepatitis C-related liver cirrhosis with hepatocellular carcinoma. Ranitidine was the most likely drug responsible for causing Stevens-Johnson syndrome in these two patients.
Lin
C C
CC
Department of Medicine, Taipei Veterans General Hospital, Taiwan, Republic of China.
Wu
J C
JC
Huang
D F
DF
Huang
Y S
YS
Huang
Y H
YH
Huo
T I
TI
Chang
F Y
FY
Lee
S D
SD
D000935:Antifungal Agents / Q000009:adverse effects; D006528:Carcinoma, Hepatocellular / Q000209:etiology; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy; D005260:Female; D006526:Hepatitis C / Q000150:complications; D006635:Histamine H2 Antagonists / Q000009:adverse effects*; D006801:Humans; D007565:Jaundice / Q000139:chemically induced; D007654:Ketoconazole / Q000009:adverse effects; D008103:Liver Cirrhosis / Q000150:complications / Q000821:virology; D008107:Liver Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008113:Liver Neoplasms / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011899:Ranitidine / Q000009:adverse effects*; D012720:Severity of Illness Index; D013262:Stevens-Johnson Syndrome / Q000139:chemically induced*
D000935:Antifungal Agents; D006635:Histamine H2 Antagonists; D011899:Ranitidine; D007654:Ketoconazole