[Relationship between insulin resistance and pregnancy induced hypertension].
OBJECTIVE
To investigate whether insulin resistance is a cause of pregnancy induced hypertension (PIH).


METHODS
All patients who had abnormal 50 g glucose screening test accepted 75 g oral glucose tolerance test (OGTT) and insulin sensitive index (ISI) was calculated. These patients were followed up and divided into two groups (PIH group and normal pregnancy group) at third trimester of pregnancy. The difference of ISI between the PIH group and normal pregnancy group was compared.


RESULTS
Fast blood glucose, fast blood insulin and ISI were (4.2 +/- 0.7) mmol/L vs. (3.8 +/- 0.7) mmol/L, (107.8 +/- 48.8) pmol/L vs. (50.4 +/- 40.5) pmol/L, and -3.25 +/- 0.27 vs. -2.58 +/- 0.66 in PIH group and normal group, respectively (P < 0.05). The areas under the curve of insulin were 1,125.6 +/- 331.0 and 1,057.6 +/- 442.2 in PIH group and normal pregnancy group, respectively (P > 0.05).


CONCLUSIONS
Insulin resistance during second trimester of pregnancy may be one of the causes of pregnancy induced hypertension.
Xu
X
X
Department of Obstetrics and Gynecology, Shanghai First People's Hospital, Shanghai 200080, China.
Qiao
M
M
Jiang
M
M
D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007333:Insulin Resistance; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology*; D011254:Pregnancy in Diabetics / Q000150:complications*