title: [Rheumatoid arthritis among mapuche aborigines. A 16 years experience in the IX Region of the Chile].
abstract: BACKGROUND
  Mapuche, Chilean natives, represent approximately 9.8% of Chilean population and in the IX region of the country, they account for 18.4% of population over 15 years old. They preserve some socio-cultural characteristics that make them different to the rest of the population.
  
  
  OBJECTIVE
  To describe the epidemiological characteristics rheumatoid arthritis among Mapuche natives.
  
  
  METHODS
  Retrospective review of patients of Mapuche origin with rheumatoid arthritis, seen at Temuco Hospital between 1980 and 1996.
  
  
  RESULTS
  Among 308 cases gathered, only 106 (93 women, aged 55 +/- 10 years old) complied with 1987 American College of Rheumatology (ACR) criteria for rheumatoid arthritis. The disease began between 29 and 52 years old in 73% of patients and the mean delay in diagnosis was 4.4 years. At diagnosis, 99% had symmetric poliarthritis, 28.3% had either fatigue, fever or weight loss, and 46.9% were in class III or in class IV of ACR-1991. Fifty three percent of patients developed Sicca syndrome, 36% developed nodules, 23% developed Raynaud phenomenon, 11% developed pulmonary involvement, 7% developed vasculitis, 5% developed neurological manifestations and 19% developed ophthalmologic involvement. Rheumatoid factor was positive in 78% and 73% had erosions. HLA DR4 was (+) in 60% of 30 patients. Thirty percent required 3 or more disease modifying drugs and prednisone over 10 mg/day. There was no correlation between functional capacity and several other features of the disease.
  
  
  CONCLUSIONS
  Mapuche rheumatoid arthritis patients are detected late and have a poor functional capacity at the time of diagnosis. They also have a higher proportion of extraarticular manifestations, more erosions and require more aggressive treatments.
authors.affiliation: Unidad de Reumatología y Departamento de Salud Pública y Medicina Interna, Facultad de Medicina Universidad de La Frontera, Temuco, Chile. jacquesp@ctcreuna.cl
authors.forename: S
authors.initials: S
authors.lastname: Kaliski
authors.forename: L
authors.initials: L
authors.lastname: Bustos
authors.forename: C
authors.initials: C
authors.lastname: Artigas
authors.forename: C
authors.initials: C
authors.lastname: Alarcón
authors.forename: M A
authors.initials: MA
authors.lastname: Vega
authors.forename: C
authors.initials: C
authors.lastname: Cárdenas
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications / Q000208:ethnology*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002677:Chile / Q000453:epidemiology; D005260:Female; D006801:Humans; D007199:Indians, South American; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies