Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.
A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha-synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.
Khan
N
N
Neurogenetics Section, Institute of Neurology, London, UK.
Graham
E
E
Dixon
P
P
Morris
C
C
Mander
A
A
Clayton
D
D
Vaughan
J
J
Quinn
N
N
Lees
A
A
Daniel
S
S
Wood
N
N
de Silva
R
R
D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D051843:Synucleins; D051844:alpha-Synuclein
D001057:Apolipoproteins E; D005819:Genetic Markers; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein