Magnetic resonance imaging of multiple sclerosis: new insights linking pathology to clinical evolution.
Magnetic resonance imaging methods allow observation of pathological changes in vivo. Magnetic resonance-based studies have provided a number of important insights into the spatio-temporal evolution of the pathology of multiple sclerosis in vivo, particularly with respect to the relation between pathology and progression of disability. Magnetic resonance techniques have shown that this pathology is not restricted to the plaques that are evident at autopsy, but also involve the so-called normal-appearing white matter. Nonconventional magnetic resonance imaging strategies such as magnetization transfer imaging and spectroscopic imaging provide measures with higher pathological specificity for myelin and axonal injury. These and other advanced magnetic resonance techniques (such as the measurement of atrophy, lesion relaxation spectra, and lesion dynamics) are affording opportunities to use observations of patients to test biologically specific hypotheses. This should help us to better define new targets for drug therapy and to assess responses to new therapeutic agents.
Matthews
P M
PM
aDepartment of Clinical Neurology and Centre for Functional Magnetic Resonance Imaging, University of Oxford, Oxford, UK.
Arnold
D L
DL
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001369:Axons / Q000473:pathology; D001921:Brain / Q000473:pathology; D004185:Disability Evaluation; D018450:Disease Progression; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000473:pathology*; D009460:Neurologic Examination
D001224:Aspartic Acid; C000179:N-acetylaspartate