title: Predictors of long-term survival after valve replacement for chronic aortic regurgitation; is M-mode echocardiography sufficient?
abstract: OBJECTIVE
  The clinical importance of pre-operative and follow-up echocardiographic studies in patients operated on for chronic severe aortic valve regurgitation is still a matter of debate. The prognostic significance of M-mode echocardiography has never been directly compared with clinical and angiographic data.
  
  
  RESULTS
  Univariate and multivariate analyses of cumulative survival were performed for clinical, echocardiographic and angiographic data of 125 patients operated on between 1975 and 1983, and followed for 13.3+/-6.4 years. Ten and 20 year survival rates were 77% and 48%, respectively. Age, NYHA class, angiographic volumes, ejection fraction, as well as M-mode echocardiographic end-systolic dimension and shortening fraction were the main pre-operative prognostic parameters for long-term survival. In a multivariate analysis the angiographic end-systolic volume index, age and preoperative NYHA class were independent pre-operative prognostic variables of long-term survival. A postoperative reduction in end-diastolic dimension of >20% predicted a significantly better late survival (74% vs 44% after 20 years, P<0.001).
  
  
  CONCLUSIONS
  Age, pre-operative NYHA class and left ventricular systolic function are the main determinants of long-term survival after valve replacement for chronic aortic regurgitation. Despite a slightly lower predictive value of echocardiography when compared to angiography, it appeared sufficient for everyday clinical decision making for valve replacement. Echocardiography within 6 months postoperatively is able to detect recovery of left ventricular function, and enables additional risk-stratification, regardless of pre-operative findings.
authors.affiliation: Division of Cardiology, University Hospital, Zurich, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Corti
authors.forename: C
authors.initials: C
authors.lastname: Binggeli
authors.forename: M
authors.initials: M
authors.lastname: Turina
authors.forename: R
authors.initials: R
authors.lastname: Jenni
authors.forename: T F
authors.initials: TF
authors.lastname: Lüscher
authors.forename: J
authors.initials: J
authors.lastname: Turina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001021:Aortic Valve / Q000000981:diagnostic imaging / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000601:surgery*; D002908:Chronic Disease; D017023:Coronary Angiography; D004452:Echocardiography; D005260:Female; D006350:Heart Valve Prosthesis; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011300:Preoperative Care; D011379:Prognosis; D015996:Survival Rate; D013997:Time Factors