Prokaryotic calmodulins: recent developments and evolutionary implications.
Ca2+ is a common intracellular second-messenger molecule in eukaryotic cells and regulates a myriad of cellular processes. Many effects of Ca2+ are mediated by calcium-binding regulatory proteins of the calmodulin superfamily. We propose the idea that calcium-binding proteins originated in high G+C Gram-positive bacteria and were later acquired by eukaryotes.
Yang
K
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School of CTI, Depaul University, Chicago, IL 60604, USA.
D000595:Amino Acid Sequence; D002135:Calcium-Binding Proteins / Q000737:chemistry* / Q000235:genetics*; D002147:Calmodulin / Q000737:chemistry* / Q000235:genetics*; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D006094:Gram-Positive Bacteria / Q000235:genetics*; D008969:Molecular Sequence Data; D011387:Prokaryotic Cells; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid
D002135:Calcium-Binding Proteins; D002147:Calmodulin