title: No induction of chromosomal aberrations in Chinese hamster ovary cells by chrysophanol.
abstract: Chrysophanol is an anthraquinone which occurs in several herbal drugs, e.g. senna, a commonly used laxative. As there are only limited data on its clastogenic potential we have investigated its capability to cause chromosomal aberrations in the Chinese hamster ovary cell assay. There were no significant increases in chromosomal aberrations when chrysophanol was tested up to its limit of solubility with or without metabolic activation. We conclude that chrysophanol had no clastogenic activity under the conditions described.
authors.affiliation: Madaus AG, Ostmerheimer Strasse 198, D-51109, Cologne, Germany. u.mengs@madaus.de
authors.forename: U
authors.initials: U
authors.lastname: Mengs
authors.forename: D
authors.initials: D
authors.lastname: Schuler
authors.forename: R R
authors.initials: RR
authors.lastname: Marshall
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000378:metabolism / Q000633:toxicity*; D016466:CHO Cells / Q000187:drug effects*; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D005260:Female; D022781:Hepatocytes / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D008940:Mitotic Index; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000880:Anthraquinones; D009153:Mutagens; C027113:chrysophanic acid