Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease.
The protein melanotransferrin (p97) is associated with the brain lesions of Alzheimer's disease (AD) and is a potential marker of the disorder. We measured serum p97 concentrations in 211 subjects: 71 patients with AD, 56 patients with non-AD-type dementia, and 84 normal control subjects. Serum p97 concentrations were elevated 3- to 4-fold in AD (median 15.00 pg/microl, interquartile range 10.20-17.00 pg/microl) as compared to non AD dementia (2.85 pg/microl, 1.93-7.15 pg/microl) and normal controls (3.20 pg/microl, 2.55-3.95 pg/microl). The mean elevation was significant at 13.54 +/- 3.72 pg/microl, even in the 38 subjects with mild AD (CDR stage 0.5-1). Receiver operating characteristic analyses confirmed an optimal diagnostic threshold of 10.0 pg/microl, which yielded over-all accuracy of 0.882 to 0.915. Serum p97 is a candidate marker of AD, even in the early stage when clinical diagnosis is most uncertain.
Kim
D K
DK
Departments of Neuropsychiatry, Seoul, South Korea
Seo
M Y
MY
Lim
S W
SW
Kim
S
S
Kim
J W
JW
Carroll
B J
BJ
Kwon
D Y
DY
Kwon
T
T
Kang
S S
SS
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000503:physiopathology; D000951:Antigens, Neoplasm; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism; D008297:Male; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000097:blood*; D058225:Plaque, Amyloid / Q000378:metabolism; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D014407:Tumor Cells, Cultured
D000951:Antigens, Neoplasm; D001057:Apolipoproteins E; D015415:Biomarkers; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D007501:Iron