title: Microsomal malonyl-CoA-sensitive carnitine acyltransferase.
abstract: Liver microsomes contain two carnitine acyltransferase activities. One of these has properties closely corresponding to those of 88 kDa mitochondrial carnitine palmitoyltransferase-1 (CPT-1). Antisera against CPT-1 cross-react with an 88 kDa microsomal protein, suggesting that CPT-1 may be targeted to both microsomal and mitochondrial membranes. However, no experiments using cDNAs corresponding to CPT-1 involving in vitro translation with microsomes or involving in vivo COS-1 cell transfection provided any evidence to support this hypothesis.
authors.affiliation: Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, U.K.
authors.forename: N M
authors.initials: NM
authors.lastname: Broadway
authors.forename: R J
authors.initials: RJ
authors.lastname: Pease
authors.forename: G
authors.initials: G
authors.lastname: Birdsey
authors.forename: N A
authors.initials: NA
authors.lastname: Turner
authors.forename: M
authors.initials: M
authors.lastname: Shayeghi
authors.forename: E D
authors.initials: ED
authors.lastname: Saggerson
mesh_terms: D000818:Animals; D002333:Carnitine Acyltransferases / Q000378:metabolism*; D002334:Carnitine O-Palmitoyltransferase / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D008316:Malonyl Coenzyme A / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism; D020033:Protein Isoforms / Q000378:metabolism; D021381:Protein Transport
chemical_list: D020033:Protein Isoforms; D008316:Malonyl Coenzyme A; D002333:Carnitine Acyltransferases; D002334:Carnitine O-Palmitoyltransferase