[Chronic low dose follicle stimulating hormone step-up regimen in the treatment of polycystic ovary syndrome related anovulatory infertility with clomiphene resistance].
OBJECTIVE
To assess the efficacy and safety of chronic low-dose follicle stimulating hormone (FSH) step-up regimen in ovulation induction of polycystic ovary syndrome(PCOS) related infertile patients with clomiphene (CC) resistance.


METHODS
Nine PCOS related infertile patients with CC resistance were enrolled for ovulation induction by chronic low-dose FSH step-up regimen, using urinary FSH (Metrodin) or recombinant human FSH (Gonal-F) 5 cycles respectively. Follicular development was monitored by transvaginal ultrasonography and serum estradiol (E2) measurements.


RESULTS
Nine out of ten cycles ovulated, among them 5 had monofollicle development, one achieved single pregnancy. No ovarian hyperstimulation syndrome(OHSS), local or systemic side effect was seen.


CONCLUSIONS
Chronic low-dose FSH step-up regimen is an effective and safe choice in inducing ovulation for CC-resistant PCOS infertile cases. Transvaginal ultrasonography and serum E2 measurement are equally important for appropriate dose adjustment and avoidance of cancellation or OHSS.
Chen
W
W
Department of Obstetrics and Gynecology, Peking Union Hospital, Peking Union Medical College, Chinese Academy of Medical Science, Beijing 100730, China.
Zhang
Y
Y
Dai
Q
Q
D000858:Anovulation / Q000188:drug therapy* / Q000209:etiology; D002996:Clomiphene / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D005300:Fertility Agents, Female / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D010062:Ovulation Induction; D011085:Polycystic Ovary Syndrome / Q000150:complications / Q000628:therapy*
D005300:Fertility Agents, Female; D002996:Clomiphene; D005640:Follicle Stimulating Hormone