title: Goblet cell carcinoid of the appendix: Investigation of the expression of beta-catenin and E-cadherin.
abstract: Goblet cell carcinoids are rare neoplasms that predominantly occur in the appendix. In this report we present a case of goblet cell carcinoid of the appendix. A 58-year-old male patient complaining of pain in the right lower quadrant was diagnosed with acute appendicitis and underwent an appendectomy. Histological examination of the resected appendix revealed goblet cell carcinoid. Infiltration of tumor cells beyond the appendix was observed and the surgically resected margin was positive for tumor cells. Carcinoembryonic antigen (CEA) was diffusely detected by immunohistochemistry, and cytokeratin 20, neuron-specific enolase (NSE), chromogranin A and serotonin were focally observed in the tumor cells. The expression of beta-catenin and E-cadherin was investigated to compare with that of typical rectal carcinoids (n = 3) and colon adenocarcinomas (n = 3). In normal colonic and rectal mucosae, beta-catenin and E-cadherin stained positive on the plasma membrane. In the case reported here, beta-catenin showed a preserved expression on the plasma membrane of goblet cell carcinoid; a pattern similar to typical carcinoids rather than to adenocarcinomas. However, E-cadherin demonstrated a reduced expression on the plasma membrane of the tumor cells. This staining pattern was identical to those both of carcinoids and of adenocarcinomas. These findings suggest the possibility that, in some cases, the adherens junctions of goblet cell carcinoids are similar to those of typical carcinoids rather than to those of adenocarcinomas.
authors.affiliation: First Department of Pathology, Kochi Medical School, Kochi, Japan. nkuroda@kochi-me.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Kuroda
authors.forename: S
authors.initials: S
authors.lastname: Mizushima
authors.forename: L
authors.initials: L
authors.lastname: Guo
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: L
authors.initials: L
authors.lastname: Tao
authors.forename: E
authors.initials: E
authors.lastname: Miyazaki
authors.forename: M
authors.initials: M
authors.lastname: Toi
authors.forename: K
authors.initials: K
authors.lastname: Naruse
authors.forename: M
authors.initials: M
authors.lastname: Hiroi
authors.forename: H
authors.initials: H
authors.lastname: Enzan
mesh_terms: D001065:Appendix / Q000473:pathology; D015820:Cadherins / Q000378:metabolism*; D002276:Carcinoid Tumor / Q000378:metabolism* / Q000473:pathology; D002430:Cecal Neoplasms / Q000378:metabolism* / Q000473:pathology; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D015534:Trans-Activators; D051176:beta Catenin
chemical_list: C495270:CTNNB1 protein, human; D015820:Cadherins; D003598:Cytoskeletal Proteins; D015534:Trans-Activators; D051176:beta Catenin