title: Resting and activated endothelial cells are increased in the peripheral blood of cancer patients.
abstract: Circulating endothelial cells (CECs) were enumerated in 20 healthy controls and 76 newly diagnosed cancer patients by means of 4-color flow cytometry. In breast cancer (n = 46) and lymphoma (n = 30) patients, both resting and activated CECs were increased by 5-fold (P <.0008 vs control). CECs significantly correlated with plasma levels of vascular cell adhesion molecule-1 and vascular endothelial growth factor. Resting and activated CECs were similar to healthy controls in 7 lymphoma patients achieving complete remission after chemotherapy, and activated CECs were found to decrease in 13 breast cancer patients evaluated before and 24 hours after quadrantectomy. (Blood. 2001;97:3658-3661)
authors.affiliation: Division of Hematology-Oncology, European Institute of Oncology, via Ripamonti 435, 20141 Milan, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Mancuso
authors.forename: A
authors.initials: A
authors.lastname: Burlini
authors.forename: G
authors.initials: G
authors.lastname: Pruneri
authors.forename: A
authors.initials: A
authors.lastname: Goldhirsch
authors.forename: G
authors.initials: G
authors.lastname: Martinelli
authors.forename: F
authors.initials: F
authors.lastname: Bertolini
mesh_terms: D001943:Breast Neoplasms / Q000097:blood* / Q000601:surgery; D002452:Cell Count; D016228:Endothelial Growth Factors / Q000097:blood; D004730:Endothelium, Vascular / Q000473:pathology*; D005434:Flow Cytometry; D006801:Humans; D008222:Lymphokines / Q000097:blood; D008223:Lymphoma / Q000097:blood* / Q000188:drug therapy; D012074:Remission Induction; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
chemical_list: D016228:Endothelial Growth Factors; D008222:Lymphokines; D019010:Vascular Cell Adhesion Molecule-1; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors