[Physiological functional evaluation of retinal implants in animal models].
Retinal implants can--by electrical stimulation--create visual impressions in people with certain kinds of degenerative retinal diseases (e.g. Retinitis Pigmentosa). Electrically evoked potentials in the retina must be transferred into the visual cortex in an orderly manner, a prerequisite for any kind of form- and movement-perception. In the current developmental stage the difficult investigations are performed in various animal models: isolated retinae of intact chicken and of RCS-rats (a model for Retinitis Pigmentosa), as well as in anesthetised rabbits, pigs and cats with intact retinae. Our investigations show that spatially selective ganglion-cell responses can be recorded following focal electrical stimulation, in healthy and as well in degenerated retinae. Registration of activities in area 17 of the visual cortex demonstrate that electrical retinal stimulation can indeed activate it.
Eckhorn
R
R
Philipps-Universität Marburg, FB Physik, AG Neurophysik, Renthof 7, 35032 Marburg. reinhard.eckhorn@physik.uni-marburg.de
Stett
A
A
Schanze
T
T
Gekeler
F
F
Schwahn
H
H
Zrenner
E
E
Wilms
M
M
Eger
M
M
Hesse
L
L
D000818:Animals; D002645:Chickens; D004195:Disease Models, Animal; D005074:Evoked Potentials, Visual / Q000502:physiology; D006801:Humans; D020007:Implants, Experimental; D008838:Microcomputers; D008839:Microelectrodes; D011474:Prosthesis Design; D019919:Prosthesis Implantation; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000503:physiopathology / Q000601:surgery*; D012162:Retinal Degeneration / Q000503:physiopathology / Q000534:rehabilitation*; D013552:Swine; D009435:Synaptic Transmission / Q000502:physiology; D014793:Visual Cortex / Q000503:physiopathology*; D014795:Visual Pathways / Q000503:physiopathology