title: Enantioselective synthesis of beta-hydroxy acid derivatives via a one-pot aldol reaction-dynamic kinetic resolution.
abstract: [reaction: see text]. Combining dynamic kinetic resolution with an aldol reaction provides access to beta-hydroxy ester derivatives with high enantiomeric purity (up to 99% ee) in a one-pot procedure. Only simple starting materials are required in this enantioselective process, and preformation of a silyl enol ether is not necessary.
authors.affiliation: Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, SE-106 91 Stockholm, Sweden.
authors.forename: F F
authors.initials: FF
authors.lastname: Huerta
authors.forename: J E
authors.initials: JE
authors.lastname: Bäckvall
mesh_terms: D000447:Aldehydes / Q000737:chemistry; D002244:Carbon / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods; D004952:Esters / Q000737:chemistry*; D004987:Ethers / Q000737:chemistry*; D007700:Kinetics; D008956:Models, Chemical
chemical_list: D000447:Aldehydes; D004952:Esters; D004987:Ethers; D002244:Carbon; C116609:3-hydroxybutanal