Exercise intolerance in mitochondrial myopathy is not related to lactic acidosis.
In a double-blinded, placebo-controlled, crossover study in seven mitochondrial myopathy patients (MM), we investigated whether lowering of lactate with dichloroacetate (DCA) can improve exercise tolerance and oxidative capacity in MM. DCA lowered plasma lactate at rest and during exercise (from 10.5 +/- 2.0 to 5.0 +/- 1.6 mM; p = 0.005) but did not improve maximal work load or VO2 in cycle exercise or phosphorous magnetic resonance spectroscopy (31P-MRS)-assessed indices of muscle oxidative metabolism. This indicates that lactate acidosis is not the primary cause of exercise intolerance in MM.
Vissing
J
J
Department of Neurology, National University Hospital, Rigshospitalet, Copenhagen, Denmark. vissing@rh.dk
Gansted
U
U
Quistorff
B
B
D000140:Acidosis, Lactic / Q000503:physiopathology*; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D016552:Ergometry; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D017240:Mitochondrial Myopathies / Q000378:metabolism / Q000503:physiopathology*; D009132:Muscles / Q000378:metabolism / Q000503:physiopathology*; D011795:Surveys and Questionnaires