Anorectic effect of dehydroepiandrosterone combined with dexfenfluramine or thionisoxetine.
Free feeding rats given supplementary 1 h access per day to a palatable dessert test meal were tested for the anorectic effect of dehydroepiandrosterone alone or in combination with either the serotonin releasing agent dexfenfluramine or the norepinephrine uptake inhibitor thionisoxetine (LY 368975). Isobolographic analysis showed that the effect of dehydroepiandrosterone combined with either dexfenfluramine or thionisoxetine was within the range predicted for additivity of action.
Rowland
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NE
Department of Psychology, University of Florida, P.O. Box 112250, Center Drive, Gainesville, FL 32611-2250, USA. nrowland@ufl.edu
Marshall
M
M
Robertson
K
K
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001067:Appetite Depressants / Q000494:pharmacology*; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D020372:Dexfenfluramine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D004357:Drug Synergism; D004435:Eating / Q000187:drug effects; D005260:Female; D005473:Fluoxetine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000494:pharmacology
D001067:Appetite Depressants; D004338:Drug Combinations; D017366:Serotonin Receptor Agonists; D005473:Fluoxetine; C093518:thionisoxetine; D003687:Dehydroepiandrosterone; D020372:Dexfenfluramine