title: Safety and immunogenicity of a conjugate vaccine against Haemophilus influenzae type b in splenectomized and nonsplenectomized patients with Cooley anemia.
abstract: Patients with thalassemia are at increased risk for infections, especially after undergoing splenectomy. Vaccinations and antimicrobial prophylaxis are recommended in these patients, but the optimal immunization schedule for Haemophilus influenzae type b (Hib) vaccine is unknown. The immunogenicity of a conjugate Hib vaccine was investigated in 57 patients with thalassemia, 32 of whom had undergone splenectomy. Anti-capsular antibodies to Hib (anti-polyribosylribitol phosphate) were measured before vaccination and 2, 6, 12, 24, and 36 months after vaccination. Immunization was well tolerated. All patients achieved protective (>1 microg/mL) antibody levels. Antibody titers declined after the initial postvaccination increase, becoming undetectable in 4 patients and decreasing to concentrations of 0.15-1 microg/mL in another 2 patients when tested 2-3 years after vaccination. Hib conjugate vaccine is safe and immunogenic in patients with thalassemia major; however, additional studies are needed to assess the need and timing of booster vaccination to maintain long-term immunity.
authors.affiliation: Clinica Pediatrica De Marchi, Istituti Clinici di Perfezionamento, 20122 Milan, Italy. Rolando.Cimaz@unimi.it
authors.forename: R
authors.initials: R
authors.lastname: Cimaz
authors.forename: C
authors.initials: C
authors.lastname: Mensi
authors.forename: E
authors.initials: E
authors.lastname: D'Angelo
authors.forename: E
authors.initials: E
authors.lastname: Fantola
authors.forename: V
authors.initials: V
authors.lastname: Milone
authors.forename: L R
authors.initials: LR
authors.lastname: Biasio
authors.forename: V
authors.initials: V
authors.lastname: Carnelli
authors.forename: A R
authors.initials: AR
authors.lastname: Zanetti
mesh_terms: D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D018073:Haemophilus Vaccines / Q000008:administration & dosage* / Q000276:immunology; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D007115:Immunization Schedule; D007117:Immunization, Secondary; D008297:Male; D012449:Safety; D013154:Spleen; D013156:Splenectomy; D013997:Time Factors; D018074:Vaccines, Conjugate / Q000008:administration & dosage / Q000276:immunology; D017086:beta-Thalassemia / Q000276:immunology* / Q000601:surgery
chemical_list: D000907:Antibodies, Bacterial; D018073:Haemophilus Vaccines; D018074:Vaccines, Conjugate