Churg-Strauss syndrome associated with montelukast.
Churg-Strauss syndrome (CSS) has recently been reported in patients with asthma receiving leukotriene receptor antagonists (LTRAs). In this paper a case of CSS after treatment with montelukast is described. As in other LTRA treated cases, prior withdrawal of maintenance oral steroid may have unmasked a previously occult CSS in the patient, but a dramatic improvement in his eosinophilia after withdrawing montelukast implied that the drug also had a direct effect in activating this condition.
Mukhopadhyay
A
A
Department of Medicine, Lister Hospital, Coreys Mill Lane, Stevenage, Herts SG1 4AB, UK.
Stanley
N N
NN
D000085:Acetates / Q000009:adverse effects*; D018927:Anti-Asthmatic Agents / Q000009:adverse effects*; D015267:Churg-Strauss Syndrome / Q000139:chemically induced*; D003521:Cyclopropanes; D005500:Follow-Up Studies; D006801:Humans; D020024:Leukotriene Antagonists / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011804:Quinolines / Q000009:adverse effects*; D013440:Sulfides
D000085:Acetates; D018927:Anti-Asthmatic Agents; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast