title: Parkinsonism and Parkinson's disease associated with long-term administration of sertraline.
abstract: Sertraline, a serotonin reuptake inhibitor, has been used to treat depression and has rarely been associated to Parkinsonism. The disease usually appears in old people a few days after sertraline administration and disappears very quickly after its withdrawal. We report a case of a woman, 81-year-old, who presented with hemiparkinsonism after long-term administration of sertraline at a dose of 100 mg/day. The symptoms disappeared 3 months after the withdrawal of the drug. However, without further administration of the drug for 14 months, the patient presented with Parkinson's disease, but responded well to levodopa.
authors.affiliation: Department of Neurology, 'Obispo Polanco' General Hospital, Teruel, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Pina Latorre
authors.forename: P J
authors.initials: PJ
authors.lastname: Modrego
authors.forename: F
authors.initials: F
authors.lastname: Rodilla
authors.forename: C
authors.initials: C
authors.lastname: Catalán
authors.forename: M
authors.initials: M
authors.lastname: Calvo
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D020734:Parkinsonian Disorders / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D020280:Sertraline / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline