title: Integration of the feline radiation hybrid and linkage maps.
abstract: The recent development of genome mapping resources for the domestic cat provides a unique opportunity to study comparative medicine in this companion animal which can inform and benefit both veterinary and human biomedical concerns. We describe here the integration and order comparison of the feline radiation hybrid (RH) map with the feline interspecies backcross (ISB) genetic linkage map, constructed by a backcross of F1 hybrids between domestic cat (Felis catus) and the Asian leopard cat (Prionailurus bengalensis). Of 253 microsatellite loci mapped in the ISB, 176 equivalently spaced markers were ordered among a framework of 424 Type I coding markers in the RH map. The integration of the RH and ISB maps resolves the orientation of multiple linkage groups and singleton loci from the ISB genetic map. This integrated map provides the foundation for gene mapping assessments in the domestic cat and in related species of the Felidae family.
authors.affiliation: Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: S
authors.initials: S
authors.lastname: Sun
authors.forename: W J
authors.initials: WJ
authors.lastname: Murphy
authors.forename: M
authors.initials: M
authors.lastname: Menotti-Raymond
authors.forename: S J
authors.initials: SJ
authors.lastname: O'Brien
mesh_terms: D000818:Animals; D002415:Cats; D002874:Chromosome Mapping; D008040:Genetic Linkage; D016678:Genome; D005838:Genotype; D018895:Microsatellite Repeats; D008957:Models, Genetic; D021101:Radiation Hybrid Mapping