Angiogenesis as a prognostic factor in invasive carcinoma of the uterine cervix.
The aim of the study was to evaluate angiogenesis as an independent prognostic factor and to determine the correlation between the angiogenic index (AI) and histologic grade of the neoplastic process in patients operated on for invasive carcinoma of the uterine cervix. Angiogenesis was assessed with immunohistochemical technique using a monoclonal antibody against human factor VIII--(F8/86 M0616, DAKO, Denmark). A positive correlation was revealed between the intensification of angiogenesis and the incidence of lymph node involvement and survival rate.
Lenczewski
A
A
Department of Gynecology and Septic Obstetrics, Medical Academy, Białystok, Poland.
Terlikowski
S
S
Famulski
W
W
Sulkowska
M
M
Kulikowski
M
M
D000328:Adult; D000911:Antibodies, Monoclonal; D002277:Carcinoma / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000473:pathology*
D000911:Antibodies, Monoclonal