Cholestasis in juvenile dermatomyositis: report of three cases.
This report describes 3 cases of juvenile dermatomyositis (juvenile DM) complicated by cholestasis. All 3 patients had typical features of juvenile DM, and all developed a cholestatic syndrome within the initial months of their disease. Liver biopsy revealed mixed (cytoplasmic and ductal) cholestasis with no abnormalities in the intrahepatic ducts in all 3 cases. Cholestasis improved or was completely reversible upon treatment with prednisone. In the 2 patients who could be followed up long term, no sequelae remained. The possible role of inflammation in the pathogenesis of cholestasis in juvenile DM is discussed.
Russo
R A
RA
Servicio de Immunología/Reumatología, Hospital de Pediatría Juan P. Garrahan, Buenos Aires, Argentina.
Katsicas
M M
MM
Dávila
M
M
Ciocca
M
M
Zelazko
M
M
D000293:Adolescent; D001706:Biopsy; D002648:Child; D002779:Cholestasis / Q000150:complications* / Q000473:pathology; D003882:Dermatomyositis / Q000150:complications*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology