Brain-gut interaction in irritable bowel syndrome: new findings of a multicomponent disease model.
Knowledge on the pathophysiology of irritable bowel syndrome has evolved, beginning with disturbances in motility to visceral hypersensitivity, and ultimately to alterations in brain-gut bi-directional communication, where neurotransmitters such as serotonin play a key role. Recently, a multicomponent disease model that integrates all these alterations was proposed. This model is divided into physiological, cognitive, emotional and behavioral components that explain the gastrointestinal as well as the constitutional symptoms. In recent years there has been an explosion of research together with new developments in pharmacological treatments for IBS that support each component of this model. This review presents recent data in favor of these alterations in IBS.
Schmulson
M J
MJ
Department of Gastroenterology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Panamerican University of Mexico, Mexico City, Mexico. maxjulio@quetzal.innsz.mx
D001921:Brain / Q000503:physiopathology*; D002490:Central Nervous System / Q000503:physiopathology; D003071:Cognition / Q000502:physiology; D003109:Colonic Diseases, Functional / Q000209:etiology* / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007422:Intestines / Q000294:innervation*; D008297:Male; D008959:Models, Neurological; D010465:Perception / Q000502:physiology; D011379:Prognosis; D018570:Risk Assessment; D012678:Sensation Disorders / Q000150:complications / Q000503:physiopathology*; D012737:Sex Factors; D013312:Stress, Physiological / Q000150:complications; D017833:Visceral Afferents