Plasmodium ookinete-secreted chitinase and parasite penetration of the mosquito peritrophic matrix.
Malaria transmission-blocking strategies aimed at disrupting parasite-mosquito interactions have the potential to make important contributions to global malaria control. It has been suggested that Plasmodium-secreted chitinase plays a crucial role in allowing the ookinete to initiate its invasion of the mosquito midgut, which suggests that this enzyme is a candidate target for blocking malaria transmission. In this review, the authors discuss Plasmodium chitinases from the molecular, biochemical and cell biology viewpoints. Future directions of study could involve developing strategies for interrupting the function of Plasmodium chitinases within the mosquito midgut, including transmission-blocking drugs or vaccines, or the development of chitinase-inhibitor-producing transgenic mosquitoes.
Langer
R C
RC
WHO Collaborating Center for Tropical Diseases, University of Texas Medical Branch, Keiller 2.138, 301 University Blvd, Galveston, TX 77555-0609, USA.
Vinetz
J M
JM
D000818:Animals; D030801:Animals, Genetically Modified; D002688:Chitinases / Q000378:metabolism*; D009033:Culicidae / Q000469:parasitology*; D006790:Host-Parasite Interactions; D008958:Models, Molecular; D010961:Plasmodium / Q000201:enzymology*
D002688:Chitinases