Spectrofluorometric determination of ibuprofen in pharmaceutical formulations.
The spectrofluorometric determination of ibuprofen in pharmaceutical tablets, creams and syrup is described. It involves excitation at 263 nm and emission at 288 nm. the linear range is 2-73 mg L(-1). Other drugs or excipients present in the different formulations do not interfere, except in the case of chlorzoxazone containing tablets. Due to its strong absorbance in the spectral range the chlorzoxazone does interfere, so that in this case the proposed method can't be applied.
Damiani
P C
PC
Departamento de Química Analitica, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, 2000, Rosario, Argentina.
Bearzotti
M
M
Cabezón
M A
MA
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000032:analysis*; D007052:Ibuprofen / Q000008:administration & dosage / Q000032:analysis*; D013053:Spectrophotometry
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007052:Ibuprofen