Oxidative stress, human genetic variation, and disease.
Oxidative stress has been implicated in numerous pathophysiological conditions and also aging. The tools for studying oxidative stress are now expanding as a result of the human genome effort and, in particular, expanding knowledge on human genetic variation. A few genetic variants, mostly in the form of single nucleotide polymorphisms of relevance to oxidative stress are already studied by a molecular epidemiologic approach. A review of the current knowledge on variant human genes that are directly implicated in human protection against oxidative stress is presented.
Forsberg
L
L
Division of Biochemical Toxicology, Karolinska Institutet, Stockholm, Sweden.
de Faire
U
U
Morgenstern
R
R
D000818:Animals; D000975:Antioxidants; D002318:Cardiovascular Diseases / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D051379:Mice; D008861:Microsomes / Q000201:enzymology; D009369:Neoplasms / Q000235:genetics; D018384:Oxidative Stress / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics; D013482:Superoxide Dismutase / Q000235:genetics; D000094765:Glutathione Peroxidase GPX1
D000975:Antioxidants; D007527:Isoenzymes; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005982:Glutathione Transferase; D005978:Glutathione; D000094765:Glutathione Peroxidase GPX1