Parkinsonism and Parkinson's disease associated with long-term administration of sertraline.
Sertraline, a serotonin reuptake inhibitor, has been used to treat depression and has rarely been associated to Parkinsonism. The disease usually appears in old people a few days after sertraline administration and disappears very quickly after its withdrawal. We report a case of a woman, 81-year-old, who presented with hemiparkinsonism after long-term administration of sertraline at a dose of 100 mg/day. The symptoms disappeared 3 months after the withdrawal of the drug. However, without further administration of the drug for 14 months, the patient presented with Parkinson's disease, but responded well to levodopa.
Pina Latorre
M A
MA
Department of Neurology, 'Obispo Polanco' General Hospital, Teruel, Spain.
Modrego
P J
PJ
Rodilla
F
F
Catalán
C
C
Calvo
M
M
D000284:Administration, Oral; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D010302:Parkinson Disease, Secondary / Q000139:chemically induced*; D020734:Parkinsonian Disorders / Q000139:chemically induced*; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D020280:Sertraline / Q000009:adverse effects* / Q000627:therapeutic use
D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline