Diffuse large cell lymphoma and t(8;22) (q24;q11) in a patient with idiopathic CD4+ T-lymphopenia.
We describe a unique case of a patient with a three-year history of idiopathic CD4(+) T cell lymphopenia (HIV negative) who presented with stage IV diffuse large cell non Hodgkin's lymphoma with t(8;22). Despite the severe lymphopenia, the patient tolerated intensive chemotherapy well and at 18 months, remains in complete remission.
Campbell
J K
JK
Departments of Haematology; Peter MacCallum Cancer Institute, East Melbourne, Victoria, Australia.
Prince
H M
HM
Juneja
S K
SK
Seymour
J F
JF
Slavin
M
M
D000974:Antibodies, Antinuclear / Q000097:blood; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D015496:CD4-Positive T-Lymphocytes; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D016403:Lymphoma, Large B-Cell, Diffuse / Q000188:drug therapy / Q000209:etiology / Q000235:genetics*; D008231:Lymphopenia / Q000097:blood / Q000150:complications* / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic
D000974:Antibodies, Antinuclear; D016682:Lupus Coagulation Inhibitor