HLA-DBR 1 alleles and the susceptibility of Iranian patients with breast cancer.
Breast cancer is considered a major malignancy among women worldwide. The contribution of genetic elements to the onset of familial breast cancer has already been established. The current study investigate the alfele frequency of HLA-DRB 1 in 36 primary operable female breast cancer patients from southern Iran by polymerase chain reaction using sequence specific primers (PCR-SSP). Results were compared with those of 36 female control subjects. Statistical analysis was performed and P values were determined for each character. Our results indicated that the frequency of HLA-DRB 1*12 allele is significantly higher in the patient group (p<0.03) compared to the control group. In addition, HLA-DRB1*11 appeared to be as the most frequent allele in the control group (29.2%) and had approximately the same distribution among the patient group (22.5%).
Ghaderi
A
A
Medical School, Shiraz University of Medical Sciences, Department of Immunology, Shiraz, Iran. immunol@sums.ac.ir
Talei
A
A
Gharesi-Fard
B
B
Farjadian
S H
SH
Amirzargar
A
A
Vasei
M
M
D000328:Adult; D000483:Alleles; D001943:Breast Neoplasms / Q000208:ethnology / Q000235:genetics*; D004273:DNA, Neoplasm / Q000032:analysis / Q000378:metabolism; D005260:Female; D020022:Genetic Predisposition to Disease; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D007492:Iran / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D012307:Risk Factors
D004273:DNA, Neoplasm; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains