title: Abdomen release in prone position does not improve oxygenation in an experimental model of acute lung injury.
abstract: OBJECTIVE
  To analyze the effect of abdomen release in the prone position on oxygenation in an experimental model of acute lung injury.
  
  
  METHODS
  Experimental randomized controlled study.
  
  
  METHODS
  Experimental laboratory of a tertiary university hospital.
  
  
  METHODS
  Mixed-breed adolescent pigs weighing between 25-31 kg.
  
  
  METHODS
  Thirty minutes after pulmonary edema was produced with oleic acid, the animals were turned prone and randomized into two groups: group I or control (n = 9), lying directly on the operating table; and group II (n = 11) with abdomen release, with positioning rolls under the upper part of the chest wall and the pelvis to allow free movement of the abdomen.
  
  
  RESULTS
  The gas exchange, respiratory mechanics, hemodynamics, intra-abdominal pressure (IAP) and the extravascular lung water (EVLW), determined by double indicator dilution method (DI), were recorded at baseline (time 0) and at 30, 60, 90, 120 and 150 min. The PaO2/FIO2 increased in both groups at 30 min after the pigs were placed in the prone position (time 60) and then decreased progressively until the end of the experimental period, with no statistical differences between the groups at any time (73.1 +/- 14.5 vs 79.5 +/- 14.9 at 150 min). Abdomen release was not associated with changes in the respiratory mechanics, EVLW or intra-abdominal pressure.
  
  
  CONCLUSIONS
  Abdomen release in prone position does not improve oxygenation in an experimental model of acute lung injury.
authors.affiliation: Department of Intensive Medicine, Virgen de las Nieves Hospital, Avenida de las Fuerzas Armadas 2, 18014 Granada, Spain. colruima@arrakis.es
authors.forename: M
authors.initials: M
authors.lastname: Colmenero-Ruiz
authors.forename: D
authors.initials: D
authors.lastname: Pola-Gallego de Guzmán
authors.forename: M M
authors.initials: MM
authors.lastname: Jiménez-Quintana
authors.forename: E
authors.initials: E
authors.lastname: Fernández-Mondejar
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D004195:Disease Models, Animal; D015633:Extravascular Lung Water; D006439:Hemodynamics; D008170:Lung Compliance; D019301:Oleic Acid; D016684:Prone Position; D011654:Pulmonary Edema / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D011659:Pulmonary Gas Exchange; D011897:Random Allocation; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy*; D015656:Respiratory Mechanics; D013552:Swine; D016896:Treatment Outcome
chemical_list: D019301:Oleic Acid