[Deletion polymorphism in the angiotensin converting enzyme gene associated with essential hypertension in Hans Chinese population].
OBJECTIVE
To investigate whether the polymorphism of the angiotensin-converting enzyme(ACE) gene is associated with essential hypertension in Chinese.


METHODS
A case-control study was carried out using 134 hypertensive (HT) and 165 normotensive (NT) subjects. The insertion/deletion (I/D) polymorphism of ACE gene was detected by polymerase chain reaction (PCR).


RESULTS
The difference of genotype and derived allele frequencies for deletion of ACE gene between hypertensive and normotensive subjects were statistically significant(i.e. 51.9% vs 15.7 and 0.69 vs 0.31 for hypertensive and normotensive respectively, P < 0.05).


CONCLUSIONS
The possession of D/D homozygote genotype of the ACE gene might be a marker for genetic susceptibility to Hans hypertension in Chinese.
Qiu
C
C
Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005.
Liu
Y
Y
Hu
A
A
Guo
Z
Z
Song
C
C
D000328:Adult; D044466:Asian People; D016022:Case-Control Studies; D002681:China; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D011110:Polymorphism, Genetic
D007703:Peptidyl-Dipeptidase A