title: Gene-environment interaction in patterns of adolescent drinking: regional residency moderates longitudinal influences on alcohol use.
abstract: BACKGROUND
  Drinking frequency escalates rapidly during adolescence. Abstinence declines markedly, and drinking monthly or more often becomes normative. Individual differences in adolescent drinking patterns are large, and some patterns are predictive of subsequent drinking problems; little, however, is known of the gene-environment interactions that create them.
  
  
  METHODS
  Five consecutive and complete birth cohorts of Finnish twins, born 1975-1979, were enrolled sequentially into a longitudinal study and assessed, with postal questionnaires, at ages 16, 17, and 18.5 years. The sample included 1786 same-sex twin pairs, of whom 1240 pairs were concordantly drinking at age 16. Maximum likelihood models were fit in longitudinal analyses of the three waves of drinking data to assess changes in genetic and environmental influences on alcohol use across adolescence. Secondary analyses contrasted twin pairs residing in rural versus those in urban environments to investigate gene-environment interactions.
  
  
  RESULTS
  Longitudinal analyses revealed that genetic factors influencing drinking patterns increased in importance across the 30-month period, and effects arising from common environmental influences declined. Distributions of drinking frequencies in twins residing in urban and rural environments were highly similar, but influences on drinking varied between the two environments. Genetic factors assumed a larger role among adolescents residing in urban areas, while common environmental influences were more important in rural settings. Formal modeling of the data established a significant gene-environment interaction.
  
  
  CONCLUSIONS
  The results document the changing impact of genetic and environmental influences on alcohol use across adolescence. Importantly, the results also reveal a significant gene-environment interaction in patterns of adolescent drinking and invite more detailed analyses of the pathways and mechanisms by which environments modulate genetic effects.
authors.affiliation: Department of Psycohology, Indiana University, Bloomington, Indiana 47405, USA. rose@indiana.edu
authors.forename: R J
authors.initials: RJ
authors.lastname: Rose
authors.forename: D M
authors.initials: DM
authors.lastname: Dick
authors.forename: R J
authors.initials: RJ
authors.lastname: Viken
authors.forename: J
authors.initials: J
authors.lastname: Kaprio
mesh_terms: D000293:Adolescent; D000428:Alcohol Drinking / Q000453:epidemiology / Q000235:genetics*; D016009:Chi-Square Distribution; D016001:Confidence Intervals; D004777:Environment; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012424:Rural Population; D012959:Socioeconomic Factors; D014505:Urban Population