title: The effect of local application of mitomycin-C on the development of capsule around silicone implants in the breast: an experimental study in mice.
abstract: In this experimental study on mice we try to prove that capsule formation around breast implants is considerably diminished after topical application of Mitomycin-C (MMC). MMC solution is applied under the breast tissue or pectoralis major muscle, in the pocket of the silicone implant and just before placing it. This is a morphological study of the connective tissue formed around the implant, under light and electron microscope. Our results suggest that it is worthwhile working on a clinical study trying to prevent the most common complication of breast implants, contracture of a capsule.
authors.forename: J
authors.initials: J
authors.lastname: Frangou
authors.forename: M
authors.initials: M
authors.lastname: Kanellaki
mesh_terms: D000328:Adult; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use*; D018427:Breast Implants; D003286:Contracture / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D051379:Mice; D016685:Mitomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D018482:Muscle, Skeletal / Q000473:pathology / Q000503:physiopathology
chemical_list: D000903:Antibiotics, Antineoplastic; D016685:Mitomycin