title: Age-related morphological changes of the deltoid muscle from 50 to 79 years of age.
abstract: A quantitative analysis of deltoid muscle biopsy specimens was performed by light microscopy in 26 males and 25 females aged 50-79 years without known neuromuscular disease. Muscle fibre size, fibre type distribution and increase in mitochondrial content in muscle fibres were examined using a semi-automatic image analysis system. This study showed significant age- and gender-related differences. In females, there was marked atrophy of type II fibres with increasing age, specially of type IIb fibres, but no significant change in muscle fibre type distribution. In males, there was diminution in the relative proportion of type IIb fibres with increasing age but no significant muscle fibre atrophy. Mitochondrial aggregates increased with age, and this increase was observed earlier in females than in males. The gender-related morphological changes observed in the present study differ somewhat from those reported in the literature. The differences between males and females may be partially related to gender differences in muscular activity and may reflect an earlier decline in deltoid muscle strength in females. The existence of these age and gender changes should be taken into account in the interpretation of muscle biopsies of aged individuals.
authors.affiliation: INSERM U 523, Institut de Myologie, Groupe Hospitalier Pitié-Salpêtrière, 47 boulevard de l'Hôpital, 75651 Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Fayet
authors.forename: A
authors.initials: A
authors.lastname: Rouche
authors.forename: J Y
authors.initials: JY
authors.lastname: Hogrel
authors.forename: F M
authors.initials: FM
authors.lastname: Tomé
authors.forename: M
authors.initials: M
authors.lastname: Fardeau
mesh_terms: D000367:Age Factors; D000368:Aged; D001706:Biopsy; D048429:Cell Size; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000648:ultrastructure; D024510:Muscle Development; D018485:Muscle Fibers, Skeletal / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000254:growth & development* / Q000648:ultrastructure; D012016:Reference Values; D012737:Sex Factors; D013194:Staining and Labeling