Neuropathogenesis of influenza virus infection in mice.
The neurovirulent WSN strain of influenza A virus, introduced into the olfactory bulb of C57BL/6 mice, selectively attacks several brain nuclei which are highly implicated in the pathogenesis of neuropsychiatric disturbances. The virus-infected neurons are eradicated through apoptotic neurodegeneration. On the other hand, activated microglia serve the neuroprotection against virus infection.
Mori
I
I
Department of Microbiology, Fukui Medical University School of Medicine, Fukui 910-1193, Japan.
Kimura
Y
Y
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D017209:Apoptosis; D001921:Brain / Q000473:pathology* / Q000821:virology; D020805:Central Nervous System Viral Diseases / Q000473:pathology* / Q000821:virology; D009980:Influenza A virus; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration; D009474:Neurons / Q000473:pathology / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000473:pathology* / Q000821:virology
D000956:Antigens, Viral