Effects of exogenous interleukin-6 during Pseudomonas aeruginosa corneal infection.
Lack of interleukin-6 (IL-6) during Pseudomonas aeruginosa corneal infection leads to more severe disease with changes in neutrophil recruitment. Exogenous IL-6 leads to increased efficiency of neutrophil recruitment and reduced bacterial loads in corneal infection in both IL-6 gene knockout and wild-type mice. This may be mediated by IL-6 increasing the production of corneal macrophage inflammatory protein 2 and intercellular cell adhesion molecule 1. We conclude that effective recruitment of neutrophils into the cornea is dependent on the production of IL-6 and that early augmentation of IL-6 may be protective in corneal infection.
Cole
N
N
Co-Operative Research Center for Eye Research and Technology, Cornea and Contact Lens Research Unit and School of Optometry, University of New South Wales, Sydney, Australia.
Krockenberger
M
M
Bao
S
S
Beagley
K W
KW
Husband
A J
AJ
Willcox
M
M
D000818:Animals; D054426:Chemokine CXCL2; D018925:Chemokines / Q000378:metabolism; D003315:Cornea / Q000276:immunology / Q000473:pathology; D003316:Corneal Diseases / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000008:administration & dosage* / Q000276:immunology*; D051379:Mice; D011552:Pseudomonas Infections / Q000276:immunology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000276:immunology
D054426:Chemokine CXCL2; D018925:Chemokines; C404915:Cxcl2 protein, mouse; D015850:Interleukin-6; D018799:Intercellular Adhesion Molecule-1