title: An unusual case of chronic neuropathic pain responds to an optimum frequency of intravenous ketamine infusions.
abstract: The effective treatment of patients suffering from a variety of difficult pain syndromes, including phantom pain and other neuropathic pains, remains a clinical challenge. Neuropathic pain has been shown to respond to drugs that block the N-methyl-D-aspartate (NMDA) receptor, such as ketamine and amantidine. A 44-year-old woman with a previous right-sided forequarter amputation presented to the Palliative Medicine Team complaining of neuropathic pain in her left arm, which was neurologically intact. The pain was treated with repeated infusions of intravenous ketamine. Twenty-one infusions were given over a period of four months. The pain intensity experienced by the patient lessened as the frequency of the ketamine infusions increased. This finding has not been described previously and supports the theory that there may be an optimum frequency of ketamine infusions to achieve adequate pain control.
authors.affiliation: Department of Palliative Medicine, Beatson Oncology Centre, Glasgow, Scotland, United Kingdom.
authors.forename: A C
authors.initials: AC
authors.lastname: Mitchell
mesh_terms: D000328:Adult; D002908:Chronic Disease; D018691:Excitatory Amino Acid Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007649:Ketamine / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010591:Phantom Limb / Q000188:drug therapy
chemical_list: D018691:Excitatory Amino Acid Antagonists; D007649:Ketamine