title: Onnamide F: a new nematocide from a southern Australian marine sponge, Trachycladus laevispirulifer.
abstract: A southern Australian marine sponge, Trachycladus laevispirulifer, has yielded a potent new nematocide with antifungal activity which has been identified as onnamide F (1). The structure for 1 was assigned by detailed spectroscopic analysis and chemical conversion to the methyl ester 2. Onnamide F contains a common structural motif previously described in a number of natural products exhibiting interesting pharmacological activities, including the insect chemical defense agent pederin (3), and the sponge metabolites the onnamides, mycalamides, and theopederins.
authors.affiliation: School of Chemistry, University of Melbourne, Parkville, Victoria, 3010, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Vuong
authors.forename: R J
authors.initials: RJ
authors.lastname: Capon
authors.forename: E
authors.initials: E
authors.lastname: Lacey
authors.forename: J H
authors.initials: JH
authors.lastname: Gill
authors.forename: K
authors.initials: K
authors.lastname: Heiland
authors.forename: T
authors.initials: T
authors.lastname: Friedel
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology; D000969:Antinematodal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D001315:Australia; D006189:Haemonchus / Q000187:drug effects; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D014020:Tissue Extracts / Q000737:chemistry / Q000633:toxicity; D000095702:Polyether Toxins
chemical_list: D000935:Antifungal Agents; D000969:Antinematodal Agents; D011714:Pyrans; D014020:Tissue Extracts; C433915:onnamide F; D000095702:Polyether Toxins