Photodegradation of 1-(2-chlorobenzoyl)-3-(4-chlorophenyl) urea in different media and toxicity of its reaction products.
The photodegradation of 1-(2-chlorobenzoyl)-3-(4-chlorophenyl) urea in simulated air, methanol, dioxane, hexane, and water, with a xenon lamp as light source, was studied. The rate constants and half-lives of this compound in various media under nitrogen or oxygen were determined. The photoreaction products were analyzed with HPLC-UV, GC-MS, and direct probe MS and found to have some differences in different cases. With (32)P postlabeling DNA adduct formation experiments, one of the main products, 2-chorobenzamide, was found to be able to form a DNA adduct.
Guoguang
L
L
Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, People's Republic of China.
Xiangning
J
J
Xiaobai
X
X
D018736:DNA Adducts; D008956:Models, Chemical; D009584:Nitrogen; D010100:Oxygen; D010777:Photochemistry; D012997:Solvents; D014508:Urea / Q000737:chemistry*
D018736:DNA Adducts; D012997:Solvents; D014508:Urea; D009584:Nitrogen; D010100:Oxygen