Presence of multiple HIV type 1 subtypes among mothers and children in Japan.
We collected blood samples from 70 HIV-1-infected pregnant women and 76 babies born to HIV-1-infected women in Japan, from 1989 to 1999. To analyze the genetic diversity of HIV-1 among mothers and children, we sequenced the C2-V3 regions of HIV-1 gp120. Phylogenetic tree analysis of these regions revealed that multiple HIV-1 subtypes, A, B, D, E, and G, were circulating among mothers and children in Japan. Thus, the genetic heterogeneity of HIV-1 among mothers and children in Japan is steadily increasing, although the number of cases remains small. Perhaps the longest term survivor, an 11-year-old child with a vertical HIV-1 subtype G infection in Japan, is one of our subjects.
Hara
T
T
Vaccine Research and Development Group, AIDS Research Center, National Institute of Infectious Diseases, Tokyo, 162-8640 Japan.
Yoshino
N
N
Takayama
N
N
Minamitani
M
M
Naganawa
S
S
Ohkubo
H
H
Takizawa
M
M
Izumi
Y
Y
Kantake
M
M
Suzuki
S
S
Takano
M
M
Kita
T
T
Totani
R
R
Nagai
Y
Y
Honda
M
M
Nakasone
T
T
D000595:Amino Acid Sequence; D001483:Base Sequence; D002648:Child; D004279:DNA, Viral; D005260:Female; D018740:Genetic Heterogeneity; D015699:HIV Envelope Protein gp120 / Q000235:genetics*; D015658:HIV Infections / Q000097:blood / Q000821:virology*; D015497:HIV-1 / Q000145:classification / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007564:Japan; D008297:Male; D008969:Molecular Sequence Data; D009035:Mothers; D010446:Peptide Fragments / Q000235:genetics*; D010802:Phylogeny; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000821:virology*
D004279:DNA, Viral; D015699:HIV Envelope Protein gp120; C059762:HIV envelope protein gp120 (305-321); D010446:Peptide Fragments