Quantitative comparison of ohmefentanyl isomers induced conditioning place preference in mice.
Differences of analgesia and withdrawal response among ohmefentanyl stereoisomers have been studied. In the present study, Quantitative comparison of reinforcing effects of ohmefentanyl stereoisomers and morphine was performed by using a conditioned place preference design in mice. Results showed that morphine and ohmefentanyl stereoisomers were able to increase significantly the time spent in the drug-paired side with respect to vehicle treated animals. A good linear correlation between doses of drugs and number of mice with place preference was found within a given dose range. On the basis of the dose-response curve analysis, ohmefentanyl stereoisomers displayed a significant difference in place preference ED50. The addictive index (analgesic ED50/place preference ED50) was used to assess the addictive potential of drugs. It was demonstrated that the addictive potential of ohmefentanyl stereoisomers did not exhibit a large difference as addictive index. Among these stereoisomers, the addictive potential of compound F9208 was markedly lower than that of morphine.
Guo
G W
GW
Shanghai Institute of Meteria Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
Liu
Z H
ZH
Jin
W Q
WQ
Zhang
H P
HP
Chen
X J
XJ
Zhu
Y C
YC
Chi
Z Q
ZQ
D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D016739:Behavior, Addictive / Q000139:chemically induced; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007536:Isomerism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology; D012054:Reinforcement, Psychology
D000701:Analgesics, Opioid; D009020:Morphine; C037016:F 7302; D005283:Fentanyl