Insulin resistance: cellular and clinical concepts.
Insulin resistance is defined as a clinical state in which a normal or elevated insulin level produces an attenuated biologic response. Specifically, the biologic response most studied is insulin-stimulated glucose disposal, yet the precise cellular mechanism responsible is not yet known. However, the presence of insulin resistance is observed many years before the onset of clinical hyperglycemia and the diagnosis of Type 2 diabetes. Insulin resistance at this stage appears to be significantly associated with a clustering of cardiovascular risk factors predisposing the individual to accelerated cardiovascular disease. An overview of insulin resistance and the associated clinical insulin resistant state will be discussed.
Cefalu
W T
WT
Department of Medicine, University of Vermont College of Medicine, Burlington 05405, USA. wcefalu@zoo.uvm.edu
D000818:Animals; D001692:Biological Transport; D002318:Cardiovascular Diseases / Q000209:etiology; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000517:prevention & control; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology* / Q000517:prevention & control; D007328:Insulin / Q000097:blood / Q000502:physiology; D007333:Insulin Resistance; D008956:Models, Chemical; D015398:Signal Transduction; D013577:Syndrome
D007328:Insulin; D006003:Glycogen; D005947:Glucose