Adamantylaminopyrimidines and -pyridines are potent inducers of tumor necrosis factor-alpha.
A series of (1-adamantyl)aminopyrimidine and -pyridine derivatives was prepared by adamantyl cation attack on amino heterocycles. The adamantylated compounds, particularly 2-(1-adamantyl)amino-6-methylpyridine, were found to be potent TNF-alpha inducers in murine melanoma cells transduced with gene for human TNF-alpha.
Kazimierczuk
Z
Z
Institute of Chemistry, Agricultural University, Rakowiecka, Warsaw, Poland. kazimierczuk@delta.sggw.waw.pl
Górska
A
A
Switaj
T
T
Lasek
W
W
D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002845:Chromatography; D008546:Melanoma, Experimental / Q000378:metabolism; D051379:Mice; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D011725:Pyridines; D011743:Pyrimidines; D014409:Tumor Necrosis Factor-alpha; D000218:Adamantane