Modulation of DMBA induced genotoxicity in bone marrow by quercetin during skin carcinogenesis.
Effect of quercetin was studied on DMBA induced skin carcinogenesis in young adult Swiss albino mice. Quercetin was administered continuously with the diet (2%) for four weeks and chromosomal aberration, a predictor of future cancer risk, studied in the bone marrow cells at different time intervals. Significant reduction of chromosomal aberration was observed in bone marrow after four weeks (P< 0.02). The reduction was first evident after 96 hrs though it was not significant at this stage. Significant decrease occurred from the 21st day onward when quercetin was given in concomitance with 7,12-dimethylbenz[a]anthracene (DMBA) indicating a definite protective effect of quercetin on chromosomal aberration.
Sengupta
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Dept. of Cancer Chemoprevention, Chittaranjan National Cancer Institute, Calcutta, India.
Ghosh
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Das
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D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001854:Bone Marrow Cells / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D002273:Carcinogens / Q000633:toxicity; D002869:Chromosome Aberrations; D051379:Mice; D009153:Mutagens / Q000633:toxicity; D011794:Quercetin / Q000494:pharmacology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000473:pathology*; D013997:Time Factors
D016587:Antimutagenic Agents; D002273:Carcinogens; D009153:Mutagens; D015127:9,10-Dimethyl-1,2-benzanthracene; D011794:Quercetin