title: Hemostatic changes in patients receiving hydroxyethyl starch: the influence of ABO blood group.
abstract: Hydroxyethyl starches (HES) interfere with coagulation because of their molecular structure and the amount infused during surgery. Coagulation defects include platelet dysfunction and a decrease of the VIII/von Willebrand factor complex (VIII/vWF). We examined the effects of 6% HES 200/0.6 on hemostasis by using an in vitro platelet function analyzer, the usual coagulation tests, the VIII/vWF complex assessment, and TEG analysis in patients undergoing abdominal surgery. The influence of the blood group was investigated. HES infusion induced primary hemostasis alterations, assessed by a prolonged platelet function analyzer closure time in the presence of epinephrine and adenosine diphosphate, which was not correlated with the platelet count. The decrease in VIII/vWF complex was proportional to the volume of infused HES (20 and 30 mL/kg) and was more pronounced in patients of the O blood group. The preoperative hypercoagulability status assessed by TEG analysis was reversed 24 h after HES infusion. In conclusion, 6% HES 200/0.6 induced immediate hemostasis alterations. Patients of the O blood group were likely to develop a von Willebrand-like syndrome after HES infusion. We conclude that intraoperative use of 6% HES 200/0.6 should be restricted in patients of the O blood group undergoing surgical procedures with high risk for bleeding.
authors.affiliation: Department of Anesthesiology, Hôpital Pitié-Salpêtrière, Paris, France. catherine.huraux@psl.ap-hop-paris.fr
authors.forename: C
authors.initials: C
authors.lastname: Huraux
authors.forename: A
authors.initials: A
authors.lastname: Ankri A
authors.forename: D
authors.initials: D
authors.lastname: Eyraud
authors.forename: O
authors.initials: O
authors.lastname: Sevin
authors.forename: F
authors.initials: F
authors.lastname: Ménégaux
authors.forename: P
authors.initials: P
authors.lastname: Coriat
authors.forename: C M
authors.initials: CM
authors.lastname: Samama
mesh_terms: D000017:ABO Blood-Group System / Q000502:physiology*; D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000494:pharmacology*; D010979:Platelet Function Tests; D013916:Thrombelastography; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D000017:ABO Blood-Group System; D001779:Blood Coagulation Factors; D006895:Hydroxyethyl Starch Derivatives; D010952:Plasma Substitutes; D014841:von Willebrand Factor