title: Prenatal diagnosis of cleft lip and palate.
abstract: A prospective study was conducted over a period of 8 years to compare the severity of the cleft lip and palate detected by ultrasound scanning of the foetus with the severity at birth. In the UK all pregnant women undergo a routine perabdominal ultrasound scan at 20 weeks' gestation. There were approximately 250000 scans performed in our catchment area during the study period. A total of 270 children were born with cleft lip and/or palate, of which 130 had cleft lip with or without cleft palate. Out of these, 23 were positively diagnosed by the ultrasound scan. The specificity was 100% and the sensitivity was 17.5%. Only two diagnoses led to termination of the pregnancy.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Frenchay Hospital, Bristol, UK.
authors.forename: D
authors.initials: D
authors.lastname: Shaikh
authors.forename: N S
authors.initials: NS
authors.lastname: Mercer
authors.forename: K
authors.initials: K
authors.lastname: Sohan
authors.forename: P
authors.initials: P
authors.lastname: Kyle
authors.forename: P
authors.initials: P
authors.lastname: Soothill
mesh_terms: D002971:Cleft Lip / Q000000981:diagnostic imaging*; D002972:Cleft Palate / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D016216:Ultrasonography, Prenatal / Q000592:standards*