[Research on immunological activity of non-immunological cells of decidua in normal early pregnancy].
OBJECTIVE
To investigate the immunological activity of non-immunological cells of decidua in normal early pregnancy.


METHODS
Harvest the supernatant from cultured non-immunological cells of decidua. Inspect the effects of the supernatant on transforming function of T cells, killing activity of natural killer cells, the IgG secretion of B cells and the interleukin-2 (IL-2) secretion by lymphocytes of human peripheral blood by radioimmunological assay (RIA).


RESULTS
The supernatant of the cultured non-immunological cells of decidua can inhibit the immunological function of T cells, natural killer cells and B cells to different extents, their maximum inhibiting ratio were 22.7%, 52.3% and 14.8% respectively, but there is no significant effect on the IL-2 secretion by lymphocytes.


CONCLUSIONS
The non-immunological cells of decidua in normal early pregnancy have immunological inhibiting function, which might contribute to prevent fetus from being expelled by maternal immunological system.
Hu
D
D
Zhujiang Hospital, First Military Medical, University, Guangzhou 510282.
Chen
Z
Z
Yan
J
J
D002478:Cells, Cultured; D003656:Decidua / Q000166:cytology / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007376:Interleukin-2 / Q000378:metabolism; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First
D007074:Immunoglobulin G; D007376:Interleukin-2