Travels with carnitine palmitoyltransferase I: from liver to germ cell with stops in between.
Although malonyl-CoA was first recognized as a central component in the regulation of hepatic ketogenesis, its inhibitory effect on mitochondrial carnitine palmitoyltransferase I (CPT I) has come to be viewed as a key element in fuel sensing in a variety of body tissues. This broadening role of the malonyl-CoA/CPT I partnership in the control of glucose and fatty acid metabolism, as well as current understanding of structure-function relationships surrounding the CPT proteins, are outlined. The intriguing question of whether CPT I has an important function in sperm development is also addressed briefly.
McGarry
J D
JD
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, U.S.A. denis.mcgarry@utsouthwestern.edu
D000103:Acetyl-CoA Carboxylase / Q000378:metabolism; D000818:Animals; D002334:Carnitine O-Palmitoyltransferase / Q000737:chemistry / Q000172:deficiency / Q000235:genetics / Q000378:metabolism*; D005854:Germ Cells / Q000201:enzymology / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008316:Malonyl Coenzyme A / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism
D008316:Malonyl Coenzyme A; D002334:Carnitine O-Palmitoyltransferase; D000103:Acetyl-CoA Carboxylase