Inhibition of experimental autoimmune vitiligo by oral administration of mushroom tyrosinase.
Experimental autoimmune vitiligo was induced by intradermal injection of mushroom tyrosinase emulsified in complete Freund's adjuvant in female C57BL/6 mice. The onset of vitiligo was characterized by hair hypopigmentation and total melanocyte depletion in the basal layer of the epidermis. Oral administration of mushroom tyrosinase prevented the expression of mushroom tyrosinase induced experimental autoimmune vitiligo. Based on the results it is likely that oral administration of mushroom tyrosinase may have practical implications in vitiligo.
Zehtab
T
T
Department of Immunology, Faculty of Medicine, Tehran University of Medical Sciences, Iran.
Yazdanparast
R
R
Rafieii
S
S
D000284:Administration, Oral; D000364:Agaricus / Q000201:enzymology*; D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D004195:Disease Models, Animal; D005260:Female; D006968:Hypersensitivity, Delayed; D051379:Mice; D008810:Mice, Inbred C57BL; D014442:Monophenol Monooxygenase / Q000008:administration & dosage / Q000276:immunology* / Q000378:metabolism / Q000627:therapeutic use*; D012867:Skin / Q000473:pathology; D014820:Vitiligo / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology
D014442:Monophenol Monooxygenase