title: Selective delta opioid receptor agonists for inflammatory and neuropathic pain.
abstract: In the last decade a number of selective and potent non-peptidic agents became available to explore the usefulness of the delta-opioid receptor in modulation of pain of different origins. As a continuing effort in this field, potent and selective delta-opioid agonists based on the pyrrolomorphinan framework have been designed, synthesised and characterised biologically in our laboratories. In animal models, a selected compound of interest, SB 235863, has proved the concept that selective delta-opioid agonists may have great potential as pain relief agents in inflammatory and neuropathic pain conditions. Importantly, such a compound was free of the unwanted side effects usually associated with narcotic analgesics such as morphine.
authors.affiliation: SmithKline Beecham SpA, Baranzate di Bollate, Milan, Italy. massimo_dondio@sbphrd.com
authors.forename: G
authors.initials: G
authors.lastname: Dondio
authors.forename: S
authors.initials: S
authors.lastname: Ronzoni
authors.forename: C
authors.initials: C
authors.lastname: Farina
authors.forename: D
authors.initials: D
authors.lastname: Graziani
authors.forename: C
authors.initials: C
authors.lastname: Parini
authors.forename: P
authors.initials: P
authors.lastname: Petrillo
authors.forename: G A
authors.initials: GA
authors.lastname: Giardina
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy; D017465:Receptors, Opioid, delta / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D000701:Analgesics, Opioid; D017465:Receptors, Opioid, delta