Estrogen receptor beta is the predominant isoform expressed in the brain of adult and fetal sheep.
OBJECTIVE
The objective of this study was to examine the expression of estrogen receptors alpha and beta in the cerebral cortex of the adult and fetal sheep.


METHODS
A reverse transcriptase-polymerase chain reaction-based approach was used to examine the expression of ovine estrogen receptor alpha and estrogen receptor beta in the cerebral cortex of 4 adult and 2 fetal sheep.


RESULTS
Estrogen receptor beta was expressed in the 4 adult and 2 fetal brain samples. Estrogen receptor alpha expression was seen in only 1 adult brain and 1 fetal brain.


CONCLUSIONS
Estrogen receptor beta is the predominant isoform expressed in the cerebral cortex of both adult and fetal sheep. These data may have implications for the many important actions of estrogen in the adult and developing ovine brain.
Deitch
H R
HR
Department of Obstetrics and Gynecology, College of Medicine, University of Cincinnati, Ohio 45267-0526, USA.
Mershon
J L
JL
Clark
K E
KE
D000375:Aging / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000196:embryology* / Q000378:metabolism*; D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D005333:Fetus / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D012756:Sheep
D047628:Estrogen Receptor alpha; D047629:Estrogen Receptor beta; D011960:Receptors, Estrogen