title: Safety and efficacy of high fluence CO2 laser skin resurfacing with a single pass.
abstract: BACKGROUND
  Carbon dioxide (CO2) laser skin resurfacing has nearly replaced more traditional methods of superficial skin rejuvenation. Post-treatment erythema is the most common side effect of this method of skin resurfacing. Sublethal thermal damage to the dermis has been proposed as an etiology for post laser erythema. Recent developments in laser resurfacing technology have aimed at minimizing thermal damage to the dermis.
  
  
  OBJECTIVE
  To determine depth of skin ablation, extent of thermal injury, and ideal laser parameters for the FeatherTouch laser system. To assess the safety and efficacy of laser resurfacing at high energy fluences with a single pass.
  
  
  METHODS
  Laser resurfacing was performed in the preauricular skin of five patients undergoing rhytidectomy. A total of 60 sites were tested with fluences of 7 to 17 Joules/cm2. Histologic evaluation of excised skin showed maximal thermal injury to be restricted to 60 microns in the papillary dermis. The reticular dermis showed no evidence of injury. Based on these findings, laser resurfacing at 17 J/cm2 (70 watts) was performed on 30 patients (in the periorbital area, a maximum of 9 J/cm2 or 36 watts was used). Follow up ranged between 12 and 18 months.
  
  
  RESULTS
  Based on histologic comparison of average and high fluence laser resurfacing, high fluence laser resurfacing did not cause added thermal damage to the reticular dermis. In the clinical group, no major complications such as scarring, scleral show, infection or ectropion were encountered. Transient hyperpigmentation was noted in three patients. Overall patient satisfaction was good to excellent. Post-treatment erythema lasted an average of 4 weeks.
  
  
  CONCLUSIONS
  We conclude that CO2 laser resurfacing of the face (excluding the periorbital region) can be performed safely and effectively, with the FeatherTouch laser, at 17 J/cm2 with one pass. In our group of patients, laser resurfacing with a single pass at 17 J/cm2 caused less post-operative erythema than two or more passes at 9 J/cm2.
authors.affiliation: Department of Otolaryngology-Head and Neck Surgery, St Luke's/Roosevelt Hospital Center, New York, NY, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Khosh
authors.forename: W F
authors.initials: WF
authors.lastname: Larrabee
authors.forename: B
authors.initials: B
authors.lastname: Smoller
mesh_terms: D000328:Adult; D000368:Aged; D002245:Carbon Dioxide; D004890:Erythema / Q000209:etiology; D005260:Female; D006801:Humans; D053685:Laser Therapy; D007834:Lasers / Q000009:adverse effects; D015361:Rhytidoplasty / Q000009:adverse effects / Q000379:methods*; D015595:Skin Aging; D016896:Treatment Outcome
chemical_list: D002245:Carbon Dioxide