A mild anionic method for generating o-quinone methides: facile preparations of ortho-functionalized phenols.
A low-temperature method for generating o-quinone methides is described which permits facile introduction of assorted R substituents onto the aryl ring system at low temperature. The method is useful for the efficient preparation of ortho-ring-alkylated phenols.
Jones
R M
RM
Department of Chemistry and Biochemistry, University of California, Santa Barbara, CA 93106-9510, USA.
Van De Water
R W
RW
Lindsey
C C
CC
Hoarau
C
C
Ung
T
T
Pettus
T R
TR
D000477:Alkylating Agents; D001685:Biological Factors / Q000138:chemical synthesis; D020650:Combinatorial Chemistry Techniques; D010636:Phenols / Q000138:chemical synthesis; D011809:Quinones / Q000138:chemical synthesis*
D000477:Alkylating Agents; D001685:Biological Factors; D010636:Phenols; D011809:Quinones