Modification of constrained peptides by ring-closing metathesis reaction.
Ring-closing metathesis (RCM) with alpha,alpha-diallylglycyl peptides is shown to furnish alpha,alpha-cyclopentenylglycyl peptides as conformationally restrained analogues in the form of post-translational type peptide modification suitable for both peptidomimetic and combinatorial chemistry applications.
Kotha
S
S
Department of Chemistry, Indian Institute of Technology-Bombay, 400 076, Mumbai, India. srk@chem.iitb.ac.in
Sreenivasachary
N
N
Mohanraja
K
K
Durani
S
S
D000498:Allyl Compounds / Q000737:chemistry*; D005998:Glycine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000138:chemical synthesis* / Q000737:chemistry; D011487:Protein Conformation
D000498:Allyl Compounds; D010456:Peptides, Cyclic; C026228:cyclopentenylglycine; C426410:diallylglycine; D005998:Glycine