HIV rounds at Cornell: selected neurologic complications of HIV disease.
Neurological disorders are among the most frequent and devastating complications of HIV infection and AIDS. As patients survive longer with the availability of highly active anti-retrovital therapy, it is likely that the frequency of some of these disorders will increase, since patients will survive long enough to develop them. The central and peripheral nervous system may be affected by numerous primary and secondary complications. These neurological disorders include HIV dementia, primary CNS lymphoma, toxoplasmosis, progressive multifocal leukoencephalopathy, vacuolar myelopathy, peripheral neuropathies, and myopathy. In this review we discuss current thoughts on clinical features, pathogenesis, diagnostic evaluation, treatment and clinical trials in several of these HIV-associated neurologic disorders.
Simpson
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Department of Neurology, Mount Sinai Medical Center, New York, New York, USA.
D015526:AIDS Dementia Complex / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use; D005260:Female; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009134:Muscular Atrophy, Spinal / Q000175:diagnosis* / Q000188:drug therapy / Q000209:etiology; D009518:New York; D014495:Universities
D019380:Anti-HIV Agents