Repression of MHC determinants in HIV infection.
HIV infects CD4(+) macrophages and lymphocytes. Before the development of AIDS, HIV weakens the immune system in part by blocking antigen processing and presentation via major histocompatibility complex (MHC) molecules. In this report, we discuss how HIV escapes the immune surveillance by MHC II molecules.
Kanazawa
S
S
Department of Medicine, Howard Hughes Medical Institute, University of California, San Francisco, California 94143-0703, USA.
Matija Peterlin
B
B
D000914:Antibodies, Viral / Q000276:immunology*; D005802:Genes, MHC Class II; D006678:HIV / Q000235:genetics / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D006801:Humans
D000914:Antibodies, Viral; D000949:Histocompatibility Antigens Class II