title: Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent.
abstract: The antineoplastic effect of Trigonella foenum graecum seed extract has been evaluated in the Ehrlich ascites carcinoma (EAC) model in Balb-C mice. Intra-peritoneal administration of the alcohol extract of the seed both before and after inoculation of EAC cell in mice produced more than 70% inhibition of tumour cell growth with respect to the control. Treatment with the extract was found to enhance both the peritoneal exudate cell and macrophage cell counts. The extract also produced a significant antiinflammatory effect. We report here the antiinflammatory and antineoplastic effects, of Trigonella foenum graecum seed extract.
authors.affiliation: Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Calcutta - 700 032, India.
authors.forename: P
authors.initials: P
authors.lastname: Sur
authors.forename: M
authors.initials: M
authors.lastname: Das
authors.forename: A
authors.initials: A
authors.lastname: Gomes
authors.forename: J R
authors.initials: JR
authors.lastname: Vedasiromoni
authors.forename: N P
authors.initials: NP
authors.lastname: Sahu
authors.forename: S
authors.initials: S
authors.lastname: Banerjee
authors.forename: R M
authors.initials: RM
authors.lastname: Sharma
authors.forename: D K
authors.initials: DK
authors.lastname: Ganguly
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000139:chemically induced / Q000517:prevention & control*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds; D029910:Trigonella
chemical_list: D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; C056164:fenugreek seed meal; D002351:Carrageenan