title: Voltammetric determination of doxazosin in tablets using rotating platinum electrode.
abstract: This study describes the voltammetric behaviour of doxazosin molecule based on the oxidation on the surface of platinum electrode in the stationary and rotating conditions and determine doxazosin in the tablets by differential pulse technique at only rotating condition. The experiments were carried out in the supporting electrolyte consisting of 0.2 M KCl and 0.2 M buffer solution in 10% (v/v) ethanol. The effect of initial potential was investigated and no adsorption effect was observed during use of +500 mV. The influence of pH on the peak current and peak potential was examined and the most symmetrical peaks were obtained at 0.5 M H2SO4 for rotating conditions. In the rotation range of 50-1000 rpm and up to 1.0x10(-5) M doxazosin, the factor affecting the voltammetric current was diffusional. The effect of rate of potential was tested between 2 and 20 mV for the stationary condition and the character of current was found to be diffusional up to 3x10(-5) M concentration of doxazosin solutions. The voltammetric determination of doxazosin in tablets was realised in the optimum rotating system conditions and depending on the statistical evaluations, acceptable results were obtained. Therefore, the method proposed in this study is practical, sensitive and accurate for the analysis of doxazosin in the quality control laboratories.
authors.affiliation: Department of Analytical Chemistry, Faculty of Pharmacy, Anadolu University, 26470, Eskişehir, Turkey.
authors.forename: G
authors.initials: G
authors.lastname: Altiokka
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000032:analysis*; D017292:Doxazosin / Q000032:analysis*; D004566:Electrodes; D010984:Platinum; D015203:Reproducibility of Results; D013607:Tablets
chemical_list: D000317:Adrenergic alpha-Antagonists; D013607:Tablets; D010984:Platinum; D017292:Doxazosin