title: Isolation and structures of hedaols A, B, and C, new bisnorditerpenes from a Japanese brown alga.
abstract: New bisnorditerpenes, hedaols A (1), B (2), and C (3), were isolated from the Japanese brown alga Sargassum sp. Their structures were determined by spectroscopic analysis. The absolute stereocenter of 1 was determined by the modified Mosher's method. Hedaols showed low cytotoxicity against P388 cells.
authors.affiliation: Department of Chemistry, Graduate School of Science, and Research Center for Materials Science, Nagoya University, Chikusa, Nagoya 464-8602, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Takada
authors.forename: R
authors.initials: R
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Suenaga
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: D
authors.initials: D
authors.lastname: Uemura
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D000459:Phaeophyceae / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D004224:Diterpenes; C433956:hedaol A; C433957:hedaol B; C433958:hedaol C