title: No association between anti-myelin oligodendrocyte glycoprotein antibodies and serum/cerebrospinal fluid levels of the soluble interleukin-6 receptor complex in multiple sclerosis.
abstract: Myelin-oligodendrocyte glycoprotein (MOG) specific antibodies (abs) are involved in autoantibody-mediated demyelination possibly contributing to lesion development in multiple sclerosis (MS). Interleukin-6 (IL-6) has been reported to play a crucial role for the pathogenesis of a MOG-induced animal model of MS. To investigate the link between anti-MOG abs production and IL-6 up-regulation in MS we determined the presence of anti-MOG abs and measured concentrations of IL-6 and its soluble receptors (sIL-6RC) in paired serum and cerebrospinal fluid (CSF) samples of MS patients and serum samples of age-matched healthy controls (HC). Anti-MOG abs were detected in 75% of MS sera, 57% of MS CSF samples and 20% of HC sera. There was no difference in IL-6 and sIL-6RC levels between anti-MOG abs positive and negative samples. Thus, no association between the presence of anti-MOG abs and serum/CSF levels of IL-6/sIL-6RC was found.
authors.affiliation: Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstrasse 7, 80336, Munich, Germany. padberg@nk-i.med.uni-muenchen.de
authors.forename: F
authors.initials: F
authors.lastname: Padberg
authors.forename: C G
authors.initials: CG
authors.lastname: Haase
authors.forename: W
authors.initials: W
authors.lastname: Feneberg
authors.forename: M J
authors.initials: MJ
authors.lastname: Schwarz
authors.forename: H
authors.initials: H
authors.lastname: Hampel
mesh_terms: D000328:Adult; D001769:Blood / Q000378:metabolism; D002555:Cerebrospinal Fluid / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology* / Q000378:metabolism*; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D019947:Receptors, Interleukin-6 / Q000378:metabolism*; D012016:Reference Values; D012995:Solubility
chemical_list: C571326:MOG protein, human; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D019947:Receptors, Interleukin-6