No evidence for linkage between COMT and schizophrenia in a French population.
Catechol-O-methyltransferase is a candidate in the predisposition to schizophrenia both because of its function and the position of its gene. A multipoint non-parametric linkage analysis and a transmission disequilibrium test were performed on 42 multiplex families genotyped for Pml I and Bcl I polymorphisms using two definitions of the affected phenotype. Neither linkage nor preferential transmission of any allele or haplotype was detected, failing to replicate previous positive findings.
de Chaldée
M
M
LGN, UMR 9923 CNRS, Bâtiment CERVI, Hôpital de la Pitié-Salpêtrière, 83 boulevard de l'Hôpital, 75013, Paris, France.
Corbex
M
M
Campion
D
D
Jay
M
M
Samolyk
D
D
Petit
M
M
Thibaut
F
F
Laurent
C
C
Mallet
J
J
D000483:Alleles; D002394:Catechol O-Methyltransferase / Q000235:genetics* / Q000378:metabolism*; D005260:Female; D005602:France / Q000453:epidemiology; D015870:Gene Expression; D020022:Genetic Predisposition to Disease; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics; D012559:Schizophrenia / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics
D002394:Catechol O-Methyltransferase