New developments in the pathology of skull base tumors.
As an anatomical interface between various tissues, the skull base harbors an exceptionally broad variety of neoplasms, some of which pose a major challenge for surgical pathology. The characterization of distinct immunohistochemical expression profiles and the identification of molecular genetic alterations associated with different tumor entities have significantly advanced this field. The new World Health Organization (WHO) classification of tumors of the nervous system lists 15 histopathological variants of meningioma. Of clinical importance are those entities that carry an increased risk of recurrence and a poor prognosis, i.e., the atypical meningioma (WHO grade II), clear-cell meningioma (WHO grade II), chordoid meningioma (WHO grade II), rhabdoid meningioma (WHO grade III), papillary meningioma (WHO grade III), and anaplastic meningioma (WHO grade III). Diagnostic criteria for atypical and anaplastic meningioma variants have now been stringently defined. The differential diagnosis of meningiomas includes hemangiopericytoma, hemangioblastoma, solitary fibrous tumor, sarcomas, and chordoid neoplasms. Recent data highlight the importance of distinguishing chordoma and chondrosarcoma of the skull base since chondrosarcomas show a significantly better clinical outcome. Among the less common, aggressive tumor entities in this anatomical region, infiltrating pituitary adenoma/pituitary carcinoma, superficial malignant gliomas, rhabdomyosarcoma, olfactory neuroblastoma, various sarcomas, and malignant lymphoma must be considered. Profiles of molecular genetic alterations have been established for several of these neoplasms and may facilitate the differential diagnosis. This review summarizes recent developments in the histopathological characterization, classification, and molecular pathology of neoplasms arising at the skull base.
Radner
H
H
German Brain Tumor Reference Center, Department of Neuropathology, University of Bonn Medical Center, Sigmund-Freud-Strasse 25, 53105 Bonn, Germany. referenzzentrum@uni-bonn.de
Katenkamp
D
D
Reifenberger
G
G
Deckert
M
M
Pietsch
T
T
Wiestler
O D
OD
D014408:Biomarkers, Tumor / Q000032:analysis; D002817:Chordoma / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D008577:Meningeal Neoplasms / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology; D008579:Meningioma / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology; D009367:Neoplasm Staging; D009442:Neurilemmoma / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology; D019292:Skull Base Neoplasms / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000473:pathology*
D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm