Specific or superfluous? Doubtful clinical value of granulocyte scintigraphy in osteomyelitis in children.
To study the clinical usefulness of granulocyte scintigraphy, eight children with clinical, laboratory and/or radiologic findings strongly suggestive of osteomyelitis were prospectively evaluated. Comparison was made with bone scintigraphy and magnetic resonance imaging. In adults, granulocyte scintigraphy is highly infection specific, although nonspecific findings (i.e. photopenic lesions) may also occur. Granulocyte scintigraphy was positive in one patient, false-negative in two and demonstrated nonspecific photopenic lesions in five children (62%). In conclusion, there appears to be little place for granulocyte scintigraphy in routine investigation of suspected ostoemyelitis in children.
Kaiser
S
S
Department of Pediatric Radiology, Astrid Lindgren Children's Hospital, Karolinska Hospital, S-171 76 Stockholm, Sweden.
Jacobsson
H
H
Hirsch
G
G
D000911:Antibodies, Monoclonal; D001842:Bone and Bones; D002648:Child; D002675:Child, Preschool; D005188:False Negative Reactions; D005260:Female; D005334:Fever / Q000209:etiology; D006098:Granulocytes; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000592:standards; D008297:Male; D010019:Osteomyelitis / Q000097:blood / Q000150:complications / Q000175:diagnosis*; D010146:Pain / Q000209:etiology; D011446:Prospective Studies; D011859:Radiography / Q000592:standards; D011868:Radioisotopes; D011877:Radionuclide Imaging / Q000379:methods* / Q000592:standards; D012680:Sensitivity and Specificity; D013667:Technetium; D013669:Technetium Tc 99m Medronate
D000911:Antibodies, Monoclonal; D011868:Radioisotopes; D013667:Technetium; D013669:Technetium Tc 99m Medronate