Differential cell death response to photodynamic therapy is dependent on dose and cell type.
PDT-induced cell death, by either apoptosis or necrosis may vary with cell type or PDT dose. 5 cell types were treated with varying doses of aminolaevulinic acid-induced PDT and the type of cell death analysed. The mode of cell death was found to depend on both cell type and light dose.
Wyld
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Section of Surgical and Anaesthetic Sciences, Division of Clinical Sciences, University of Sheffield, Floor K, Royal Hallamshire Hospital, Sheffield, S10 2JF, UK.
Reed
M W
MW
Brown
N J
NJ
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D001943:Breast Neoplasms; D002279:Carcinoma 256, Walker; D016923:Cell Death / Q000187:drug effects*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D016158:Genes, p53; D006801:Humans; D010778:Photochemotherapy; D051381:Rats; D014407:Tumor Cells, Cultured; D001749:Urinary Bladder Neoplasms