title: Adamantylaminopyrimidines and -pyridines are potent inducers of tumor necrosis factor-alpha.
abstract: A series of (1-adamantyl)aminopyrimidine and -pyridine derivatives was prepared by adamantyl cation attack on amino heterocycles. The adamantylated compounds, particularly 2-(1-adamantyl)amino-6-methylpyridine, were found to be potent TNF-alpha inducers in murine melanoma cells transduced with gene for human TNF-alpha.
authors.affiliation: Institute of Chemistry, Agricultural University, Rakowiecka, Warsaw, Poland. kazimierczuk@delta.sggw.waw.pl
authors.forename: Z
authors.initials: Z
authors.lastname: Kazimierczuk
authors.forename: A
authors.initials: A
authors.lastname: Górska
authors.forename: T
authors.initials: T
authors.lastname: Switaj
authors.forename: W
authors.initials: W
authors.lastname: Lasek
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D002845:Chromatography; D008546:Melanoma, Experimental / Q000378:metabolism; D051379:Mice; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
chemical_list: D011725:Pyridines; D011743:Pyrimidines; D014409:Tumor Necrosis Factor-alpha; D000218:Adamantane