Tissue engineering of vascular bypass grafts: role of endothelial cell extraction.
Surgical treatment of vascular disease has become common. The use of synthetic materials is limited to grafts larger than 5-6 mm, because of the frequency of occlusion observed with small-diameter prosthetics. An alternative would be a hybrid or tissue-engineered graft with the surface coated with a monolayer of the patients' own endothelial cells. This review examines the various techniques and technologies used to date in order to extract endothelial cells for such graft engineering.
Tiwari
A
A
Vascular Haemodynamic Unit, University Department of Surgery, Royal Free and University College Medical School, Unuiversity College London, The Royal Free Hospital, London NW3 2QG, U.K.
Salacinski
H J
HJ
Hamilton
G
G
Seifalian
A M
AM
D001698:Biomedical Engineering / Q000379:methods*; D001807:Blood Vessel Prosthesis; D018929:Cell Culture Techniques / Q000379:methods; D017690:Cell Transplantation / Q000502:physiology*; D001026:Coronary Artery Bypass; D004727:Endothelium / Q000166:cytology* / Q000637:transplantation*; D006801:Humans; D016491:Peripheral Vascular Diseases / Q000601:surgery; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D014654:Vascular Patency
D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene