title: Glassy cell carcinoma of the endometrium: a case report and review of the literature.
abstract: Endometrial glassy cell carcinoma (GCC) is a rare neoplasm, with 11 cases reported in the literature. Although GCC is considered to be a poorly differentiated variant of adenosquamous carcinoma, its real nature is still debatable. We report a case of GCC of the endometrium in a 60-year-old woman and review the literature. The patient presented with vaginal bleeding, and pelvic computed tomographic scan showed a polypoid lesion in the uterine fundus. Histologically, the tumor showed 2 components: a moderately differentiated adenocarcinoma with extensive areas of squamous metaplasia (adenoacanthoma) and a GCC. The clinical stage of the patient's disease was IB as classified by the International Federation of Gynecology and Obstetrics. She was treated by a total abdominal hysterectomy, bilateral salpingo-oophorectomy, and pelvic radiation therapy. The patient was still alive and free of disease at 5 years of follow-up.
authors.affiliation: Department of Pathology, Basel University Hospital, Basel, Switzerland.
authors.forename: P
authors.initials: P
authors.lastname: Mhawech
authors.forename: A
authors.initials: A
authors.lastname: Dellas
authors.forename: L M
authors.initials: LM
authors.lastname: Terracciano
mesh_terms: D018196:Carcinoma, Adenosquamous / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008679:Metaplasia; D008875:Middle Aged; D010052:Ovariectomy