title: Electrochemical behaviour of sertraline at a hanging mercury drop electrode and its determination in pharmaceutical products.
abstract: The electrochemical behaviour of sertraline at a hanging mercury drop electrode (HMDE) was described. Different voltammetric techniques, such as cyclic, linear sweep, differential pulse and square wave voltammetry, were used. Voltammograms were obtained at different pH values with a Britton-Robinson buffer solution used as supporting electrolyte. The best results were found by square wave voltammetry with electrodeposition at alkaline pH using a borate buffer with a pH = 8.2 for the samples, containing 12% (v/v) methanol. Under optimised conditions, a linear relationship between 2.33 x 10(-7) and 3.15 x 10(-6) M of sertraline with a limit of detection of 1.98 x 10(-7) M was obtained. The electrochemical method developed was applied to the determination of sertraline in pharmaceutical formulations. Recoveries were close to 100%, thus proving efficacy of the proposed method for the quantification of sertraline in commercial samples.
authors.affiliation: CEQUP/Departamento de Química-Física, Faculdade de Farmácia, Universidade do Porto, Portugal.
authors.forename: M H
authors.initials: MH
authors.lastname: Vela
authors.forename: M B
authors.initials: MB
authors.lastname: Quinaz Garcia
authors.forename: M C
authors.initials: MC
authors.lastname: Montenegro
mesh_terms: D000928:Antidepressive Agents / Q000032:analysis / Q000737:chemistry; D004563:Electrochemistry / Q000379:methods; D008628:Mercury; D015394:Molecular Structure; D004364:Pharmaceutical Preparations / Q000032:analysis / Q000737:chemistry; D012680:Sensitivity and Specificity; D020280:Sertraline / Q000032:analysis* / Q000737:chemistry*
chemical_list: D000928:Antidepressive Agents; D004364:Pharmaceutical Preparations; D008628:Mercury; D020280:Sertraline