Two new fatty diterpenoids from Salvia miltiorrhiza.
Two new fatty abietane diterpenoids, oleoyl neocryptotanshinone (1) and oleoyl danshenxinkun A (2), were isolated as minor components from the roots of Salvia miltiorrhiza. Their structures were established on the basis of spectral evidence. In preliminary tests, they selectively inhibited rabbit platelet aggregation induced by arachidonic acid.
Lin
H C
HC
School of Pharmacy, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Ding
H Y
HY
Chang
W L
WL
D000818:Animals; D002681:China; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006868:Hydrolysis; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D009829:Oleic Acids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D011817:Rabbits; D013056:Spectrophotometry, Ultraviolet
D004224:Diterpenes; D009829:Oleic Acids; D010975:Platelet Aggregation Inhibitors; C433954:oleoyl danshenxinkun A; C433953:oleoyl neocryptotanshinone