Synthesis and action on the central nervous system of 8-substituted 6,7,8,9-tetrahydro-5H-1,2,4-triazolo[4,3-a]-diazepine derivatives.
Selected 8-substituted 6,7,8,9-tetrahydro-5H-1,2,4-triazolo[4,3-a] diazepine derivatives were synthesised and tested for their action on the central nervous system. The obtained results showed that the examined compounds type IV have sedative activity. The strongest effect was exerted by compound IV-f.
Guryn
R
R
Department of Technology and Chemistry of Drugs, Medical University, 1 Muszyńskiego Str., 90-151 Łódź, Poland.
Pakulska
W
W
Brzezińska
E
E
D000818:Animals; D014151:Anti-Anxiety Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines