Pyrrolidine nucleic acids: DNA/PNA oligomers with 2-hydroxy/aminomethyl- 4-(thymin-1-yl)pyrrolidine-N-acetic acid.
Synthesis of pyrrolidine-based chiral positively charged DNA analogues is reported. The synthesis of (2S,4S) and (2R,4R) thymin-1-ylpyrrolidine-N-acetic acid, its site specific incorporation in PNA:DNA chimera and PNA, and the study of their binding properties with complementary DNA/RNA sequences is presented.
Kumar
V
V
Division of Organic Chemistry (Synthesis), National Chemical Laboratory, Pune 411008, India. vkumar@dna.ncl.res.in
Pallan
P S
PS
Meena
M
M
Ganesh
K N
KN
D001483:Base Sequence; D002851:Chromatography, High Pressure Liquid; D018076:DNA, Complementary / Q000737:chemistry*; D018716:Molecular Mimicry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009693:Nucleic Acid Hybridization / Q000379:methods*; D009696:Nucleic Acids / Q000138:chemical synthesis* / Q000737:chemistry; D016376:Oligonucleotides, Antisense / Q000138:chemical synthesis* / Q000737:chemistry; D020135:Peptide Nucleic Acids / Q000737:chemistry*; D011759:Pyrrolidines / Q000138:chemical synthesis* / Q000737:chemistry; D018075:RNA, Complementary / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet; D013941:Thymine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry
D018076:DNA, Complementary; D009696:Nucleic Acids; D016376:Oligonucleotides, Antisense; D020135:Peptide Nucleic Acids; D011759:Pyrrolidines; D018075:RNA, Complementary; C427923:thymin-1-ylpyrrolidine-N-acetic acid; D013941:Thymine