Quantitative analysis of metronidazole in intravenous admixture with ciprofloxacin by first derivative spectrophotometry.
Metronidazole in parenteral admixture with ciprofloxacin was analysed by first-derivative spectrophotometry using the zero-crossing technique of measurement. The procedure did not require prior separation steps. The method was found to be linear (r(2)>0.999) in the range of 2.5-10 microg ml(-1) for metronidazole in absence or presence (at constant concentration) of ciprofloxacin. The first-derivative method was applied for the analysis of intravenous admixture of metronidazole and ciprofloxacin and proved to be rapid, accurate and reproducible.
Vega
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E
Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria-5000, Córdoba, Argentina.
Solá
N
N
D000890:Anti-Infective Agents / Q000032:analysis*; D002939:Ciprofloxacin / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D008795:Metronidazole / Q000032:analysis*; D013053:Spectrophotometry
D000890:Anti-Infective Agents; D008795:Metronidazole; D002939:Ciprofloxacin