The virulence for gnotobiotic pigs of live attenuated vaccine strains of Salmonella enterica serovars Typhimurium and Enteritidis.
Gnotobiotic pigs were inoculated orally with wild-type or defined aroA or cya crp vaccine strains of Salmonella enterica serovars Typhimurium and S. Enteritidis. The parental strains were virulent, inducing severe diarrhoea, dehydration and systemic disease. The cya crp mutant was also highly virulent whereas the aroA strains were attenuated.
Barrow
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Institute for Animal Health, Compton Laboratory, Compton, Berkshire, RG20 7NN, Newbury, UK. paul.barrow@bbsrc.ac.uk
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Lovell
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D000262:Adenylyl Cyclases / Q000235:genetics / Q000276:immunology; D000818:Animals; D001428:Bacterial Vaccines / Q000235:genetics / Q000494:pharmacology*; D015169:Colony Count, Microbial; D005798:Genes, Bacterial; D005856:Germ-Free Life; D009154:Mutation; D011953:Receptors, Cyclic AMP / Q000235:genetics; D012480:Salmonella Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D022562:Salmonella Vaccines / Q000235:genetics / Q000276:immunology; D012477:Salmonella enteritidis / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D012486:Salmonella typhimurium / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity*; D013552:Swine; D014436:Typhoid-Paratyphoid Vaccines / Q000235:genetics / Q000276:immunology; D014613:Vaccines, Attenuated / Q000235:genetics / Q000494:pharmacology; D014774:Virulence
D001428:Bacterial Vaccines; D011953:Receptors, Cyclic AMP; D022562:Salmonella Vaccines; D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated; C087350:aroA Salmonella vaccine; D000262:Adenylyl Cyclases