title: NMR studies on three optical active drug molecules.
abstract: NMR spectroscopy is one of very few methods that enable deep insight into molecular structure and distinguishing of enantiomers. It usually requires the use of optically active agents that differentiate S and R forms through an interaction with studied molecule differentiate S and R forms. The aim of the present studies was to perform a preliminary NMR study on three chiral drugs: Fluoxetine hydrochloride, Ibuprofen, and Zolmitriptan by use of three optical solvating agents: R(-) 2,2,2-trifluoro-1-(9-anthryl)ethanol (I), (R)(+) 1,1'-bi-2-naphthol (II), and (S) tert-butyl-phenylphosphinothioic acid (III).
authors.affiliation: Drug Institute, 30/34 Chełmska Str. 00-725 Warsaw, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Bednarek
authors.forename: J C
authors.initials: JC
authors.lastname: Dobrowolski
authors.forename: A P
authors.initials: AP
authors.lastname: Mazurek
mesh_terms: D016861:Cyclooxygenase Inhibitors / Q000737:chemistry*; D005473:Fluoxetine / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009904:Optical Rotation; D023303:Oxazolidinones / Q000737:chemistry*; D017366:Serotonin Receptor Agonists / Q000737:chemistry*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry*; D014363:Tryptamines
chemical_list: D016861:Cyclooxygenase Inhibitors; D005473:Fluoxetine; D007052:Ibuprofen; D023303:Oxazolidinones; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors; D014363:Tryptamines; C089750:zolmitriptan