title: Genetic polymorphism of CYP2D6 in Karnataka and Andhra Pradesh population in India.
abstract: OBJECTIVE
  To study the prevalence of cytochrome P-450 2D6 (CYP2D6) polymorphism in Karnataka (KA) and Andhra Pradesh (AP) population.
  
  
  METHODS
  Two hundred and eleven healthy human volunteers participated in the study (100 from KA and 111 from AP). At bed time, after voiding their bladder, the volunteers ingested 30 mg of dextromethorphan hydrobromide (DM). Urine samples were collected for 8 h. DM and its metabolite dextrorphan (DT) were estimated in the urine using HPLC. The metabolic ratio (DM/DT) was used for phenotyping.
  
  
  RESULTS
  The prevalence of poor metabolisers (PM) in KA is 4% and AP is 1.8%.
  
  
  CONCLUSIONS
  The frequency of PM phenotype in South Indian population is in between the Western and Oriental population.
authors.affiliation: Clinical Pharmacology Unit, Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry-605 006, India.
authors.forename: B K
authors.initials: BK
authors.lastname: Abraham
authors.forename: C
authors.initials: C
authors.lastname: Adithan
authors.forename: P U
authors.initials: PU
authors.lastname: Kiran
authors.forename: M
authors.initials: M
authors.lastname: Asad
authors.forename: K
authors.initials: K
authors.lastname: Koumaravelou
mesh_terms: D000293:Adolescent; D000328:Adult; D019389:Cytochrome P-450 CYP2D6 / Q000235:genetics*; D003915:Dextromethorphan / Q000378:metabolism; D005260:Female; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011110:Polymorphism, Genetic
chemical_list: D003915:Dextromethorphan; D019389:Cytochrome P-450 CYP2D6