Estradiol potentiates antiarrhythmic and antioxidative effects of intermittent hypoxic rat heart.
OBJECTIVE
To study the effects of estradiol (Est) on antiarrhythmic and antioxidative effects of intermittent hypoxia in rat heart.


METHODS
Ligating and loosening the coronary artery of rat to induce ischemic and reperfusion arrhythmias, using arrhythmia score (AS) to evaluate the arrhythmias, measuring the activity of superoxide dismutase (SOD) and the content of malondialdehyde (MDA) in myocardium.


RESULTS
AS of arrhythmia induced by ischemia and reperfusion in intermittent hypoxia 28-d group (IH28) and in intermittent hypoxia with Est group (IH14-Est) are lower than that in control group (CON), respectively. AS of ischemic arrhythmia but not reperfusion arrhythmia in Est treated group (ESTG) was lower than that in CON. No significant difference in AS of ischemia and reperfusion existed among CON, vehicle group (VEH), and intermittent hypoxia 14-d group (IH14). The activity of SOD was higher and the content of MDA was lower in IH28 and in IH14-Est compared with that in CON. No significant difference of the activity of SOD and the content of MDA existed among CON, VEH, IH14, and ESTG.


CONCLUSIONS
Est potentiated the antiarrhythmic and antioxidative effects of intermittent hypoxia on rat heart.
Zhang
Y
Y
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031, China.
Zhong
N
N
Zhou
Z N
ZN
D000532:Altitude Sickness / Q000150:complications / Q000378:metabolism; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D017202:Myocardial Ischemia / Q000378:metabolism*; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013482:Superoxide Dismutase / Q000378:metabolism
D000889:Anti-Arrhythmia Agents; D000975:Antioxidants; D004958:Estradiol; D008315:Malondialdehyde; D013482:Superoxide Dismutase