Breast cancer cellular proliferation indexes and 99mTc-sesta Mibi capture: what correlation?
Aim of this study was to verify existing correlations between breast cancer 99mTc-sestaMIBI cells uptake and their cytological characteristics. Forty-five patients with clinically and/or mammographically suspect breast cancer were enrolled. In all patients 99mTc-sestaMIBI scintimammography was performed and malignant lesions were detected in 44 cases and benign in one case. In positive uptake (PU) lesions with diameter <1.5cm, 85.7% showed a high tumor grade (II-III degrees) while in negative uptake (NU) lesions with diameter <1.5cm, 100% showed a low tumor grade (I degrees). In PU lesions, 70% had expressed a high value of Ki 67, while 100% of the NU lesions showed normal values. In this series, tumor diameter does not play a basic role, while the correlations between uptake and the histological grade (G) and/or cellular kinetics (Ki67) seem to be more important. Further studies are needed to confirm our present results.
Bonazzi
G
G
Dept. of Clinical Physiopathology, Università degli Studi di Torino, Italy.
Cistaro
A
A
Bellò
M
M
Bessone
M
M
Tetti
M
M
Villata
E
E
Coluccia
C
C
Ardine
M
M
Moz
G
G
Massaioli
N
N
Bisi
G
G
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D002455:Cell Division; D005260:Female; D006801:Humans; D008875:Middle Aged; D008940:Mitotic Index; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011859:Radiography; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi / Q000627:therapeutic use*
D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi