Reduced immunoglobulin kappa/lambda light chain ratio in perinatally HIV-1-infected children.
In 27 perinatally human immunodeficiency virus type 1 (HIV-1)-infected children, we measured, by immunonephelometry, the kappa/lambda light chain ratio (KLR) of serum immunoglobulins. The latter is a recently available laboratory index reflecting the balance between the synthesis of K isotypes and L isotypes. KLR was consistent over time in each subject, and was significantly lower than that of an age-matched normal population, independently of disease status and therapy. These data indicate a bias, in these subjects, to produce preferentially lambda rather than kappa light chains, contributing to the multiple B-cell abnormalities in HIV-1-infected children.
Saitta
M
M
Laboratory of Clinical Chemistry and Microbiology, Regina Margherita Children's Hospital, Turin, Italy.
Gaido
F
F
Palomba
E
E
Cirina
P
P
Giaccone
A
A
Ciuti
E
E
Tovo
P
P
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000635:transmission; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D015483:HIV Antibodies / Q000096:biosynthesis; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis*; D007146:Immunoglobulin lambda-Chains / Q000096:biosynthesis*; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000276:immunology
D015483:HIV Antibodies; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains