title: Validation of a software designed for computed tomographic (CT) measurement of lung water.
abstract: OBJECTIVE
  The in-vitro validation of a computed tomographic (CT) software specifically designed for quantifying the volume of water contained in the lung.
  
  
  METHODS
  An in-vitro, ex-vivo study. In 1993, a postmortem left pneumonectomy was performed in a patient who died from acute respiratory distress syndrome. The lung was fixed, inflated and dried according to a technique proposed by Markarian and Dailey in 1975 aimed at producing a lung specimen spongy in texture and suitable for radiography.
  
  
  RESULTS
  In 1999, 13 CT scans of this lung specimen were performed corresponding to different bronchial instillations of known volumes of water and albumin 4%. The different lung weights resulting from the successive bronchial instillations were calculated using a specially designed software, Lungview, adapted for CT measurements and compared with the actual lung weight measured by an electronic scale. The increase in lung weight measured by Lungview was closely correlated with the actual increase in lung weight resulting from bronchial instillation of water and albumin (y = 0.99x - 23, r = 1 for water and y = x - 17, r = 1 for albumin 4%) and the precision of the bias was 7 g for water and 3 g for albumin 4%.
  
  
  CONCLUSIONS
  This study shows that the CT software Lungview accurately measured the volume of lung water present within an air-dried exsanguine human lung.
authors.affiliation: Réanimation Chirurgicale Pierre Viars, Département d'Anesthésie-Réanimation, Hôpital de la Pitié-Salpêtrière, University of Pierre et Marie Curie Paris VI, 47-83 boulevard de l'Hôpital, 75013 Paris, France.
authors.forename: L M
authors.initials: LM
authors.lastname: Malbouisson
authors.forename: F
authors.initials: F
authors.lastname: Préteux
authors.forename: L
authors.initials: L
authors.lastname: Puybasset
authors.forename: P
authors.initials: P
authors.lastname: Grenier
authors.forename: P
authors.initials: P
authors.lastname: Coriat
authors.forename: J J
authors.initials: JJ
authors.lastname: Rouby
mesh_terms: D000368:Aged; D001344:Autopsy; D015982:Bias; D015633:Extravascular Lung Water / Q000000981:diagnostic imaging*; D006801:Humans; D007249:Inflammation; D008297:Male; D009929:Organ Size; D011013:Pneumonectomy; D012128:Respiratory Distress Syndrome / Q000000981:diagnostic imaging* / Q000276:immunology / Q000473:pathology; D012986:Software Validation; D014057:Tomography, X-Ray Computed / Q000295:instrumentation / Q000379:methods / Q000592:standards*