title: Prolonged bone marrow failure with monosomy 7 after engraftment failure following bone marrow transplantation.
abstract: A patient with acute myelogenous leukemia developed prolonged bone marrow failure along with the monosomy 7 chromosome abnormality. The patient had undergone bone marrow transplantation with CD34+ selection following induction failure. However, she then suffered engraftment failure and long-term pancytopenia. Her white blood cell count gradually increased with supportive therapy including granulocyte colony-stimulating factor (G-CSF), and chromosomal analysis of bone marrow cells revealed an abnormal karyotype. Thirty months after the bone marrow transplantation we observed monosomy 7 together with the existing chromosomal abnormality in the patient's bone marrow cells. It has been reported that some patients with idiopathic and posthepatitis aplastic anemia develop clonal disorders such as myelodysplastic syndrome/acute myelogenous leukemia with monosomy 7. The findings in our case suggest that the appearance of monosomy 7 in patients with aplastic anemia may be caused by prolonged low-level hematopoiesis, with or without G-CSF stimulation.
authors.affiliation: Department of Pediatrics, Hokkaido University School of Medicine, Kitaku Sapporo, Japan. r-koba@med.hokudai.ac.jp
authors.forename: R
authors.initials: R
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Arioka
authors.forename: M
authors.initials: M
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Cho
authors.forename: A
authors.initials: A
authors.lastname: Iguchi
authors.forename: M
authors.initials: M
authors.lastname: Kaneda
authors.forename: T
authors.initials: T
authors.lastname: Shikano
mesh_terms: D000293:Adolescent; D000741:Anemia, Aplastic / Q000150:complications / Q000235:genetics* / Q000628:therapy; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002897:Chromosomes, Human, Pair 7; D020732:Cytogenetic Analysis; D005260:Female; D006085:Graft Survival / Q000235:genetics*; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D009006:Monosomy / Q000235:genetics*; D010198:Pancytopenia / Q000209:etiology
chemical_list: D016179:Granulocyte Colony-Stimulating Factor