Control-relevant modeling in drug delivery.
The development of control-relevant models for a variety of biomedical engineering drug delivery problems is reviewed in this paper. A summary of each control problem is followed by a review of relevant patient models from literature, an examination of the control approaches taken to solve the problem, and a discussion of the control-relevance of the models used in each case. The areas examined are regulating the depth of anesthesia, blood pressure control, optimal cancer chemotherapy, regulation of cardiac assist devices, and insulin delivery to diabetic patients.
Parker
R S
RS
Department of Chemical and Petroleum Engineering, 1249 Benedum Hall, University of Pittsburgh, Pittsburgh, PA 15261, USA. rparker@engrng.pitt.edu
Doyle
F J
FJ
D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use; D001698:Biomedical Engineering; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D016503:Drug Delivery Systems; D006439:Hemodynamics; D006801:Humans; D007328:Insulin / Q000008:administration & dosage*; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism
D000970:Antineoplastic Agents; D007328:Insulin