title: [Effect of nitric oxide on the myoelectric activity of sphincter of Oddi and arterial blood pressure of rabbit].
abstract: Thirty-two rabbits were used to investigate the effect of nitric oxide (NO) on the myoelectric activity of the sphincter of Oddi (SO) and arterial blood pressure. Intravenous infusion of NG-nitro-L-arginine (L-NNA), an inhibitor of nitric oxide synthase (NOS), caused increase in SO phasic wave amplitude and arterial blood pressure. The increase in SO phasic wave amplitude by infusion of L-NNA was reversed by L-arginine, but arterial blood pressure remained at a high level. It was observed that SO phasic wave amplitude, frequency and arterial blood pressure were significantly decreased by intravenously infusion of sodium nitroprusside (SNP), a substance producing NO. These observations suggest that (1) NO inhibits the resting activity of SO and modulates relaxation of vascular smooth muscle; (2) different tissues show different responses to L-NNA and L-arginine.
authors.affiliation: Department of Pathophysiology and Outpatient Department, Hebei Medical University, Shijiazhuang 050017.
authors.forename: M
authors.initials: M
authors.lastname: Zhang
authors.forename: C H
authors.initials: CH
authors.lastname: Ding
authors.forename: L W
authors.initials: LW
authors.lastname: Zhang
authors.forename: S Y
authors.initials: SY
authors.lastname: Yang
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004576:Electromyography; D004594:Electrophysiology; D008297:Male; D009130:Muscle, Smooth / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology*; D019335:Nitroarginine / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D011817:Rabbits; D009803:Sphincter of Oddi / Q000502:physiology*
chemical_list: D009599:Nitroprusside; D019335:Nitroarginine; D009569:Nitric Oxide