Method development for the high-performance liquid chromatographic enantioseparation of 2-cyanocycloalkanols.
An indirect high-performance liquid chromatographic method is developed for the enantioseparation of cis- and trans-2-cyanocyclopentanol and -cyclohexanol. The racemic cis-(1S,2S and 1R,2R)- or trans-(1S,2R and 1R,2S)-2-cyanocycloalkanols are converted to their diastereomers formed with (S)-(+)- or (R)-(-)-alpha-methoxy-alpha-(trifluoromethyl)phenylacetyl chloride. The diastereomers are separated on a reversed-phase column, and the conditions of derivatization and HPLC analysis are optimized.
Török
G
G
Department of Inorganic and Analytical Chemistry, University of Szeged, Hungary.
Péter
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Forró
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Fülöp
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