title: Reproducibility of the clinical criteria (ABCDE rule) and dermatoscopic features (7FFM) for the diagnosis of malignant melanoma.
abstract: Dermatoscopy improves the sensitivity and the specificity in the diagnosis of melanoma. Although the reproducibility of dermatoscopic features has been the subject of research, no study up to now has compared the reproducibility of dermatoscopic features to the reproducibility of the clinical criteria of the ABCDE rule. For this reason we decided to examine the reproducibility of the clinical ABCDE rule and of our diagnostic dermatoscopic method 7FFM, as well as of the individual criteria of both. A total of 73 dermatologists attended three dermatoscopic courses and examined a set of clinical and dermatoscopic slides of 50 pigmented skin tumors. Agreement % and K value for a kappa statistical analysis have been calculated to evaluate inter-rater reliability. The clinical and the dermatoscopic methods showed similar values of concordance: clinical score 2 mean agreement = 68%, mean K = 0.44; clinical score 3 mean agreement = 73%, mean K = 0.61; 7FFM mean agreement = 83%, mean K = 0.64. The clinical criteria A, B, and C and the dermatoscopic features of our method presented similar values of concordance as well: clinical criteria mean K range 0.35-0.25, dermatoscopic features mean K range 0.62-0.25. The dermatoscopic features of our method 7FFM show a good reproducibility after a short training program, similar to the reproducibility of the clinical criteria of the ABCDE rule for the diagnosis of melanoma.
authors.affiliation: Institute of Dermatologic Sciences, University of Milan, Ospedale Maggiore di Milano, IRCCS Milano, via Pace 9, 20122 Milan, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Benelli
authors.forename: E
authors.initials: E
authors.lastname: Roscetti
authors.forename: V
authors.initials: V
authors.lastname: Dal Pozzo
mesh_terms: D000465:Algorithms; D002985:Clinical Protocols / Q000592:standards*; D003663:Decision Trees; D003880:Dermatology / Q000193:education; D016002:Discriminant Analysis; D004502:Education, Medical, Continuing; D006801:Humans; D008545:Melanoma / Q000473:pathology*; D008853:Microscopy / Q000379:methods* / Q000592:standards*; D015588:Observer Variation; D010808:Physical Examination / Q000379:methods* / Q000592:standards*; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D012878:Skin Neoplasms / Q000473:pathology*