title: New molecular approaches to lung cancer: biological and clinical implications of P53, P16 and K-RAS studies.
abstract: The most common genetic changes associated with lung cancer involve abnormalities of the genes that regulate the cell cycle. Molecular networking of P53 and P16 tumor suppressor genes and K-RAS oncogene exerts a crucial impact on cell cycle regulation and appears to be of major clinical significance for lung cancer evaluation. The present review article summarizes evaluations of P53, P16 and K-RAS in lung cancer with particular focus on biological and clinical implications, as well as on new molecular approaches to the study of these genes: P53 by yeast functional assay, P16 by methylation specific PCR (MSP) and K-RAS by enriched PCR technique.
authors.affiliation: Department of Histology and Embryology, Medical Academy, Białystok, Poland. niklinsj@cksr.ac.bialystok.pl
authors.forename: W
authors.initials: W
authors.lastname: Niklinska
authors.forename: L
authors.initials: L
authors.lastname: Chyczewski
authors.forename: J
authors.initials: J
authors.lastname: Niklinski
mesh_terms: D000818:Animals; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D016147:Genes, Tumor Suppressor / Q000235:genetics; D019942:Genes, p16 / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D016283:Proto-Oncogene Proteins p21(ras) / Q000235:genetics*
chemical_list: C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)