title: Glycosidase inhibition by cyclic sulfonium compounds.
abstract: Inhibitory activities of various cyclic sulfonium compounds including salacinol against several glycosidases were studied and some compounds showed significant inhibition. The sulfonium ion structure was found to be essential for the inhibitory activity. Specific inhibition of salacinol toward rice alpha-glucosidase was ascribed to the tether arm.
authors.affiliation: Department of Life Science, Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology, Yokohama, Japan. hyuasa@bio.titech.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Yuasa
authors.forename: J
authors.initials: J
authors.lastname: Takada
authors.forename: H
authors.initials: H
authors.lastname: Hashimoto
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D001411:Geobacillus stearothermophilus / Q000201:enzymology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D012275:Oryza / Q000201:enzymology; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013329:Structure-Activity Relationship; D013452:Sulfonium Compounds / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D013452:Sulfonium Compounds; D006026:Glycoside Hydrolases