title: Lymphocytic infundibulo-neurohypophysitis associated with recurrent optic neuritis.
abstract: A 38-year-old woman presented with diabetes insipidus. The T1-weighted images showed a loss of the hyperintense signal of the posterior pituitary and thickening of the pituitary stalk. DDAVP was started with the diagnosis of lymphocytic infundibulo-neurohypophysitis (LINH). Three months later, she complained of right visual acuity loss. MRI revealed right optic nerve swelling, compatible with the diagnosis of the retrobulbar optic neuritis. She had two other such episodes in the next 3 months. She developed a transient oculomotor and abducens nerve palsies as well. Each time the symptoms disappeared with corticosteroid therapy. The pituitary stalk became normal in size 6 months later. LINH and recurrent optic neuritis occurred in a short duration. Accordingly, a common causative background is suspected. Since the auto-immune process has been hypothesized as a cause of optic neuritis, our case may present further clinical evidence to support the hypothesis of an auto-immune mechanism for LINH.
authors.affiliation: Departments of Neurosurgery and Ophthalmology, Chiba University School of Medicine, Inohana 1-8-1, Chuo-ku, Chiba City, Chiba 260-8670, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tamiya
authors.forename: N
authors.initials: N
authors.lastname: Saeki
authors.forename: A
authors.initials: A
authors.lastname: Mizota
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications* / Q000175:diagnosis; D003919:Diabetes Insipidus / Q000150:complications / Q000276:immunology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008279:Magnetic Resonance Imaging; D009902:Optic Neuritis / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D010900:Pituitary Diseases / Q000150:complications* / Q000175:diagnosis / Q000276:immunology; D010904:Pituitary Gland, Posterior; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D005938:Glucocorticoids; D011239:Prednisolone