Highly regioselective Friedländer reaction.
[reaction: see text]. A highly regioselective Friedländer reaction is described. By introduction of a phosphonate group at one of the alpha-carbons of a ketone, regioselectivity can be perfectly controlled.
Hsiao
Y
Y
Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. yi_xiao@merck.com
Rivera
N R
NR
Yasuda
N
N
Hughes
D L
DL
Reider
P J
PJ
D002244:Carbon / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D008956:Models, Chemical; D009287:Naphthyridines / Q000138:chemical synthesis*; D010710:Phosphates / Q000737:chemistry
D007659:Ketones; D009287:Naphthyridines; D010710:Phosphates; D002244:Carbon; D000432:Methanol