title: Milk--blood transfer of (14)C-tagged polycyclic aromatic hydrocarbons (PAHs) in pigs.
abstract: Polycyclic aromatic hydrocarbons (PAHs) are lipophilic organic pollutants occurring widely in the terrestrial environment. To study the transfer of PAHs in the food chain, pigs have been fed with milk spiked either with [(14)C]phenanthrene or with [(14)C]benzo[a]pyrene. The analysis of blood radioactivity showed that both PAHs were absorbed with a maximum concentration at 5--6 h after milk ingestion, similar to fat metabolism. The blood radioactivity then decreased to reach background levels 24 h after milk ingestion. Furthermore, the blood radioactivity was higher for phenanthrene (even if the injected load was the lowest) than for benzo[a]pyrene, in agreement with their solubility difference. These findings suggest that milk fat and PAHs were absorbed during the same time period.
authors.affiliation: Ecole Nationale d'Agronomie et des Industries Alimentaires, INRA-INPL, B.P. 172, F-54505 Vandoeuvre-lès-Nancy, France.
authors.forename: C
authors.initials: C
authors.lastname: Laurent
authors.forename: C
authors.initials: C
authors.lastname: Feidt
authors.forename: E
authors.initials: E
authors.lastname: Lichtfouse
authors.forename: N
authors.initials: N
authors.lastname: Grova
authors.forename: F
authors.initials: F
authors.lastname: Laurent
authors.forename: G
authors.initials: G
authors.lastname: Rychen
mesh_terms: D000818:Animals; D001580:Benzopyrenes / Q000008:administration & dosage*; D001682:Biological Availability; D002247:Carbon Isotopes; D007408:Intestinal Absorption; D008297:Male; D008892:Milk / Q000737:chemistry; D010616:Phenanthrenes / Q000008:administration & dosage*; D011084:Polycyclic Aromatic Hydrocarbons / Q000032:analysis / Q000378:metabolism*; D013552:Swine; D013997:Time Factors
chemical_list: D001580:Benzopyrenes; D002247:Carbon Isotopes; D010616:Phenanthrenes; D011084:Polycyclic Aromatic Hydrocarbons; C031181:phenanthrene