Local and systemic immune responses to rectal administration of recombinant cholera toxin B subunit in humans.
The induction of immune responses to rectally administered recombinant cholera toxin B subunit (CTB) in humans was studied. Three immunizations induced high levels of CTB-specific antibody-secreting cells, particular of the immunoglobulin A isotype, in both rectum and peripheral blood. Antitoxin antibody responses in rectal secretions and serum were also found.
Jertborn
M
M
Department of Medical Microbiology and Immunology, Department of Gastroenterology, Sahlgrenska University Hospital, Göteborg, Sweden. marianne.jertborn@microbio.gu.se
Nordström
I
I
Kilander
A
A
Czerkinsky
C
C
Holmgren
J
J
D000285:Administration, Rectal; D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology; D002772:Cholera Toxin / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology*; D022121:Cholera Vaccines / Q000008:administration & dosage* / Q000235:genetics / Q000276:immunology*; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000276:immunology*; D012007:Rectum / Q000276:immunology; D014734:Vibrio cholerae / Q000276:immunology
D000907:Antibodies, Bacterial; D022121:Cholera Vaccines; D011994:Recombinant Proteins; D002772:Cholera Toxin