title: [Changes in the blood coagulation system in pregnancy].
abstract: Extensive alterations of the coagulation system occur during pregnancy: Increasing levels of coagulation factors and continuous decrease of coagulation inhibitor protein S contribute to the increase of prothrombotic potential. Moreover, enhanced activation of coagulation factors, platelets and fibrinolytic system can be demonstrated by determination of activation parameters like prothrombin fragment F 1 + 2, beta-thromboglobulin and D-dimer. The alterations in the coagulation system are one cause for the enhanced thromboembolic risk during pregnancy.
authors.affiliation: Zentrum für Innere Medizin, Medizinische Klinik IV, Klinikstr. 36, 35385 Giessen. Bettins.Kemkes-Matthes@innere.med.uni-giessen.de
authors.forename: B
authors.initials: B
authors.lastname: Kemkes-Matthes
mesh_terms: D001779:Blood Coagulation Factors / Q000378:metabolism; D001780:Blood Coagulation Tests; D005260:Female; D005342:Fibrinolysis / Q000502:physiology; D006470:Hemorrhage / Q000097:blood / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D015539:Platelet Activation / Q000502:physiology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000097:blood / Q000175:diagnosis*; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood / Q000175:diagnosis*
chemical_list: D001779:Blood Coagulation Factors