High remission rate in acute myeloblastic leukemia with only two days of chemotherapy.
Twenty five patients with AML who had neither a history of toxic exposure or myelodysplasia were treated with a remission induction regimen consisting of two pulses of chemotherapy separated by 96 hrs. Each pulse consisted of cytarabine 2gm/m(2) (at t=0 and t=12 hrs) with mitoxantrone [30mg/m(2) ] administered immediately after the second cytarabine administration. Amifostine was administered three times a week [on Monday, Wednesday, and Friday] until the outcome of therapy was known. This regimen induced complete remissions in 15 of 17 patients less than 70 years of age and in 5 of 8 patients older than 70 years.
Preisler
H D
HD
Rush Cancer Institute; Chicago Illinois 60612, USA.
Venugopal
P
P
Gregory
S A
SA
Adler
S
S
Gezer
S
S
Hsu
W T
WT
Manson
S
S
Larson
A
A
Jajeh
A
A
Slvinick
D
D
Galvez
A
A
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000592:standards; D015331:Cohort Studies; D003561:Cytarabine / Q000008:administration & dosage / Q000592:standards; D020732:Cytogenetic Analysis; D004334:Drug Administration Schedule; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000145:classification / Q000188:drug therapy* / Q000235:genetics; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage / Q000592:standards; D012074:Remission Induction; D013997:Time Factors; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D003561:Cytarabine; D008942:Mitoxantrone