[Conformational changes in DNA during development of spontaneous leukosis in AKR mice].
The dynamics of conformational changes in thymus and spleen DNA of 3-9-month old mice line AKR during the development of spontaneous lymphoid leukosis was studied by the retention on nitrocellulose filters. It was shown that the degree of DNA condensation for healthy and deceased animals differs, which is probably due to different intensity of endogenous oxidation. Seasonal conformational changes in spleen DNA from healthy mice of line F1 were revealed.
Zhizhina
G P
GP
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow, 117977 Russia.
Skalatskaia
S I
SI
Burlakova
E B
EB
D000327:Adsorption; D000375:Aging; D000818:Animals; D003101:Collodion; D004273:DNA, Neoplasm / Q000737:chemistry* / Q000378:metabolism; D005260:Female; D007945:Leukemia, Lymphoid / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D009690:Nucleic Acid Conformation; D009929:Organ Size; D010084:Oxidation-Reduction; D012621:Seasons; D013154:Spleen / Q000737:chemistry / Q000473:pathology; D013950:Thymus Gland / Q000737:chemistry / Q000473:pathology
D004273:DNA, Neoplasm; D003101:Collodion