An assessment of the utility of single nucleotide polymorphisms (SNPs) for forensic purposes.
This paper assesses the use of single nucleotide polymorphisms (SNPs) for forensic analysis. It demonstrates that relatively small arrays of approx. 50 loci are comparable to existing short tandem repeat (STR) multiplexes. A quantitative test, however, is a prerequisite for mixture interpretation. In addition, as the mixture proportion becomes low, it will be necessary to distinguish between the allele and background. Relatively small biallelic arrays are also suitable to distinguish between closely related individuals such as brothers.
Gill
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Forensic Science Service, Trident Court, 2960 Solihull Parkway, Birmingham Business Park, Birmingham B37 7YN, UK.
D000483:Alleles; D001801:Blood Stains; D002648:Child; D016172:DNA Fingerprinting; D005260:Female; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D015233:Models, Statistical; D010334:Paternity; D020641:Polymorphism, Single Nucleotide; D011902:Rape