Trigonella foenum graecum (fenugreek) seed extract as an antineoplastic agent.
The antineoplastic effect of Trigonella foenum graecum seed extract has been evaluated in the Ehrlich ascites carcinoma (EAC) model in Balb-C mice. Intra-peritoneal administration of the alcohol extract of the seed both before and after inoculation of EAC cell in mice produced more than 70% inhibition of tumour cell growth with respect to the control. Treatment with the extract was found to enhance both the peritoneal exudate cell and macrophage cell counts. The extract also produced a significant antiinflammatory effect. We report here the antiinflammatory and antineoplastic effects, of Trigonella foenum graecum seed extract.
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P
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Division of Pharmacology and Experimental Therapeutics, Indian Institute of Chemical Biology, 4, Raja S. C. Mullick Road, Calcutta - 700 032, India.
Das
M
M
Gomes
A
A
Vedasiromoni
J R
JR
Sahu
N P
NP
Banerjee
S
S
Sharma
R M
RM
Ganguly
D K
DK
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002286:Carcinoma, Ehrlich Tumor / Q000139:chemically induced / Q000517:prevention & control*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds; D029910:Trigonella
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D010936:Plant Extracts; C056164:fenugreek seed meal; D002351:Carrageenan