title: Immunohistochemical study on proliferative activity of experimental cholesteatoma.
abstract: In this study, we induced canal ligation cholesteatoma using Mongolian gerbils and investigated the hyperproliferative nature of canal ligation cholesteatoma by using an immunohistochemical technique with proliferation markers (cytokeratin 13/16, PCNA, EGFR, thrombomodulin). Canal ligation cholesteatoma using Mongolian gerbils had a hyperproliferative character in the suprabasal cell layer similar to human cholesteatomas. This result will provide a good morphological basis for future cholesteatoma animal research concerning the pathogenesis of cholesteatoma.
authors.affiliation: Department of Otolaryngology, Ajou University School of Medicine, 5 Wonchon-Dong, Paldal-Gu, Suwon 442-721, Korea. parkkh@madang.ajou.ac.kr
authors.forename: K
authors.initials: K
authors.lastname: Park
authors.forename: H J
authors.initials: HJ
authors.lastname: Park
authors.forename: Y M
authors.initials: YM
authors.lastname: Chun
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D018424:Cholesteatoma, Middle Ear / Q000473:pathology*; D004424:Ear Canal / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D066246:ErbB Receptors / Q000032:analysis; D006168:Guinea Pigs; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D018180:Thrombomodulin / Q000032:analysis
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D018180:Thrombomodulin; D007633:Keratins; D066246:ErbB Receptors