Oleic acid-induced lung injury: thin-section CT evaluation in dogs.
OBJECTIVE
To validate lung attenuation measurements for quantifying extravascular lung water in oleic acid-induced pulmonary edema, compare subjective assessment with attenuation measurements, and compare this permeability-type pulmonary edema with hydrostatic-type pulmonary edema.


METHODS
Thin-section computed tomography (CT) and pulmonary hemodynamic examinations were performed sequentially in six dogs before and after intravenous administration of 0.08 mg of oleic acid per kilogram of body weight. Extravascular lung water and pulmonary capillary pressure were measured. Results were compared with those reported in a canine model of hydrostatic edema.


RESULTS
Oleic acid induced a progressive increase in extravascular lung water without a change in capillary pressure, which indicated pure permeability-type edema. Ground-glass opacification was detected as soon as extravascular lung water increased. Lung attenuation was highly correlated to extravascular lung water (r = 0.76, P<.001), as in hydrostatic edema, but was characterized by an almost absent gravitational gradient.


CONCLUSIONS
Thin-section CT is sensitive for early detection and quantification of oleic acid-induced pulmonary edema in a canine model. Different from early canine hydrostatic edema, which is characterized by a gravitational gradient, early oleic acid-induced pulmonary edema in a supine dog is characterized by nearly homogeneous distribution, except for ventral sparing.
Scillia
P
P
Department of Radiology, Erasme University Hospital, University of Brussels, Route de Lennik, 808-1070 Brussels, Belgium. pscillia@ulb.ac.be
Kafi
S A
SA
Mélot
C
C
Keyzer
C
C
Naeije
R
R
Gevenois
P A
PA
D000818:Animals; D002199:Capillary Permeability; D004285:Dogs; D015633:Extravascular Lung Water / Q000000981:diagnostic imaging; D008168:Lung / Q000000981:diagnostic imaging; D019301:Oleic Acid; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000000981:diagnostic imaging*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
D019301:Oleic Acid