Uptake, transport, and delivery of antimicrobial agents by human polymorphonuclear neutrophils.
Polymorphonuclear neutrophils (PMN) are attracted to sites of infection. They have the potential to deliver antimicrobial agents to these sites if the agents enter the cells and do not alter migration. Penicillin G did not enter cells and was not transported by PMN. We found that azithromycin, ciprofloxacin, levofloxacin, moxifloxacin, and telithromycin were concentrated in PMN and transported toward a chemoattractant. These antimicrobial agents were released from the PMN and inhibited the growth of bacteria on test plates.
Mandell
G L
GL
Division of Infectious Diseases, University of Virginia Health System, Charlottesville, Virginia 22908-1341, USA. gm@virginia.edu
Coleman
E
E
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D001692:Biological Transport; D002634:Chemotaxis, Leukocyte; D006801:Humans; D008826:Microbial Sensitivity Tests; D009504:Neutrophils / Q000378:metabolism* / Q000502:physiology
D000900:Anti-Bacterial Agents