[Primary study on the use of ovariectomized rabbits for establishment of osteoporosis model].
Purebred New Zealand female rabbits were used in this study for demonstrating the feasibility of establishing rabbit's primary osteoporosis model. Bilateral ovariectomies were performed. Five to eight months after operation, we observed the BMD, weight, hair colour and living condition of the model. After killing the rabbits, we made biomechanical detection and pathologic histomorphometry using the bones. The weight of bone ash, the content of calcium and phosphorus, and the weight of metra were determined. The results showed that BMD, bone bending stress, weight of bone ash, content of calcium and phosphorus in ash, and weight of metra all decreased (P < 0.05); the number of trabecula decreased and the bone cortex became thinner. All these parameters evidenced the primary founding of rabbit's osteoporosis model. This research provides a basis for studying the pathogenesis of primary osteoporosis and evaluating the efficacy of pharmacotherapy.
Yang
X
X
Department of Biochemistry, West China University of Medical Sciences, Chengdu 610041.
Cai
G
G
Wei
L
L
Hou
J
J
Li
J
J
Zheng
H
H
Weng
L
L
D000818:Animals; D001696:Biomechanical Phenomena; D015519:Bone Density; D004195:Disease Models, Animal; D005260:Female; D005269:Femur / Q000503:physiopathology; D006801:Humans; D015663:Osteoporosis, Postmenopausal / Q000473:pathology / Q000503:physiopathology; D010052:Ovariectomy; D011817:Rabbits; D013977:Tibia / Q000473:pathology