title: Analgesic and antiinflammatory activities of vernonioside B2 from Vernonia condensata.
abstract: Vernonioside B2 isolated from the methanol extract of the Brazilian herb Vernonia condensata Baker was evaluated in vivo for analgesic and antiinflammatory activities. The compound reduced writhings (93.28%) and Evans blue dye diffusion (91.80%) induced by acetic acid (0.1 N) in a dose-dependent manner.
authors.affiliation: NPPN, Universidade Federal do Rio de Janeiro, CCS, Bloco H, Ilha do Fundão, Rio de Janeiro, Brazil, CEP 21941-590.
authors.forename: A L
authors.initials: AL
authors.lastname: Valverde
authors.forename: G L
authors.initials: GL
authors.lastname: Cardoso
authors.forename: N A
authors.initials: NA
authors.lastname: Pereira
authors.forename: A J
authors.initials: AJ
authors.lastname: Silva
authors.forename: R M
authors.initials: RM
authors.lastname: Kuster
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019659:Asteraceae; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D005960:Glucosides; D010936:Plant Extracts; C433066:vernonioside B2; D019342:Acetic Acid