title: Randomized trial of progressive resistance training to counteract the myopathy of chronic heart failure.
abstract: Chronic heart failure (CHF) is characterized by a skeletal muscle myopathy not optimally addressed by current treatment paradigms or aerobic exercise. Sixteen older women with CHF were compared with 80 age-matched peers without CHF and randomized to progressive resistance training or control stretching exercises for 10 wk. Women with CHF had significantly lower muscle strength (P < 0.0001) but comparable aerobic capacity to women without CHF. Exercise training was well tolerated and resulted in no changes in resting cardiac indexes in CHF patients. Strength improved by an average of 43.4 +/- 8.8% in resistance trainers vs. -1.7 +/- 2.8% in controls (P = 0.001), muscle endurance by 299 +/- 66% vs. 1 +/- 3% (P = 0.001), and 6-min walk distance by 49 +/- 14 m (13%) vs. -3 +/- 19 m (-3%) (P = 0.03). Increases in type I fiber area (9.5 +/- 16%) and citrate synthase activity (35 +/- 21%) in skeletal muscle were independently predictive of improved 6-min walk distance (r2 = 0.78; P = 0.0024). High-intensity progressive resistance training improves impaired skeletal muscle characteristics and overall exercise performance in older women with CHF. These gains are largely explained by skeletal muscle and not resting cardiac adaptations.
authors.affiliation: Nutrition, Exercise Physiology, and Sarcopenia Laboratory, Jean Mayer United States Department of Agriculture, Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA.
authors.forename: C T
authors.initials: CT
authors.lastname: Pu
authors.forename: M T
authors.initials: MT
authors.lastname: Johnson
authors.forename: D E
authors.initials: DE
authors.lastname: Forman
authors.forename: J M
authors.initials: JM
authors.lastname: Hausdorff
authors.forename: R
authors.initials: R
authors.lastname: Roubenoff
authors.forename: M
authors.initials: M
authors.lastname: Foldvari
authors.forename: R A
authors.initials: RA
authors.lastname: Fielding
authors.forename: M A
authors.initials: MA
authors.lastname: Singh
mesh_terms: D000222:Adaptation, Physiological; D000368:Aged; D001835:Body Weight / Q000502:physiology; D002908:Chronic Disease; D005081:Exercise Therapy; D005260:Female; D006333:Heart Failure / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D018482:Muscle, Skeletal / Q000473:pathology*; D010101:Oxygen Consumption / Q000502:physiology; D010349:Patient Compliance; D012449:Safety; D014891:Weight Lifting / Q000502:physiology*