Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease.
Leishmaniasis affects approximately 2 million people each year throughout the world. This high incidence is due in part to the lack of an efficacious vaccine. We present evidence that the recombinant leishmanial antigens LmSTI1 and TSA, which we identified and characterized previously, induce excellent protection in both murine and nonhuman primate (rhesus monkey) models of human cutaneous leishmaniasis. The remarkable protection induced by LmSTI1 and TSA in an animal model that is evolutionarily close to humans qualifies this antigen combination as a promising candidate subunit vaccine against human leishmaniasis.
Campos-Neto
A
A
Infectious Disease Research Institute, Seattle, Washington 98104, USA. acampos@idri.org
Porrozzi
R
R
Greeson
K
K
Coler
R N
RN
Webb
J R
JR
Seiky
Y A
YA
Reed
S G
SG
Grimaldi
G
G
D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood; D000953:Antigens, Protozoan / Q000235:genetics / Q000276:immunology*; D004195:Disease Models, Animal; D006360:Heat-Shock Proteins / Q000235:genetics / Q000276:immunology; D006801:Humans; D018320:Leishmania major / Q000276:immunology*; D016773:Leishmaniasis, Cutaneous / Q000517:prevention & control*; D008253:Macaca mulatta; D051379:Mice; D008807:Mice, Inbred BALB C; D009363:Neoplasm Proteins; D010544:Peroxidases / Q000235:genetics / Q000276:immunology; D061105:Peroxiredoxin III; D054464:Peroxiredoxins; D015800:Protozoan Proteins; D016052:Protozoan Vaccines / Q000235:genetics / Q000276:immunology*; D011994:Recombinant Proteins / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014611:Vaccination
D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D006360:Heat-Shock Proteins; D009363:Neoplasm Proteins; C516116:Prdx3 protein, mouse; D015800:Protozoan Proteins; D016052:Protozoan Vaccines; D011994:Recombinant Proteins; C109320:stress-inducible protein 1, Leishmania major; D010544:Peroxidases; C516115:PRDX3 protein, human; D061105:Peroxiredoxin III; D054464:Peroxiredoxins