Cytogenetic study of six cases of radiation-induced meningiomas.
It is known that, following radiotherapy, secondary cancer may occur after a long latent period. Few cytogenetic studies have been reported on tumors of the central nervous system occurring after radiotherapy. We report the cytogenetic study of six cases of radiation-induced meningiomas. In all cases, we observed the same chromosome abnormality, der(1)(1qter-->1p11::22q12-->22pter). SKY and CGH techniques allowed us to identify the chromosomal abnormalities. We suggest that a gene localized on 1p13 is involved in radiation-induced meningiomas.
Zattara-Cannoni
H
H
Cytogenetic Oncology Laboratory, C.H.U. Timone-Marseille 264, Rue Saint-Pierre, 13385, Marseille Cedex 5, France.
Roll
P
P
Figarella-Branger
D
D
Lena
G
G
Dufour
H
H
Grisoli
F
F
Vagner-Capodano
A M
AM
D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D008577:Meningeal Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008579:Meningioma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000235:genetics* / Q000473:pathology; D009693:Nucleic Acid Hybridization