title: A comparison of machine learning methods for the diagnosis of pigmented skin lesions.
abstract: We analyze the discriminatory power of k-nearest neighbors, logistic regression, artificial neural networks (ANNs), decision tress, and support vector machines (SVMs) on the task of classifying pigmented skin lesions as common nevi, dysplastic nevi, or melanoma. Three different classification tasks were used as benchmarks: the dichotomous problem of distinguishing common nevi from dysplastic nevi and melanoma, the dichotomous problem of distinguishing melanoma from common and dysplastic nevi, and the trichotomous problem of correctly distinguishing all three classes. Using ROC analysis to measure the discriminatory power of the methods shows that excellent results for specific classification problems in the domain of pigmented skin lesions can be achieved with machine-learning methods. On both dichotomous and trichotomous tasks, logistic regression, ANNs, and SVMs performed on about the same level, with k-nearest neighbors and decision trees performing worse.
authors.affiliation: Decision Systems Group, Brigham and Women's Hospital, Division of Health Sciences and Technology, Harvard Medical School, Massachusetts Institute of Technology, Boston, Massachusetts, USA.
authors.forename: S
authors.initials: S
authors.lastname: Dreiseitl
authors.forename: L
authors.initials: L
authors.lastname: Ohno-Machado
authors.forename: H
authors.initials: H
authors.lastname: Kittler
authors.forename: S
authors.initials: S
authors.lastname: Vinterbo
authors.forename: H
authors.initials: H
authors.lastname: Billhardt
authors.forename: M
authors.initials: M
authors.lastname: Binder
mesh_terms: D000465:Algorithms; D003663:Decision Trees; D003936:Diagnosis, Computer-Assisted; D006801:Humans; D016015:Logistic Models; D008545:Melanoma / Q000175:diagnosis; D016571:Neural Networks, Computer; D009506:Nevus / Q000175:diagnosis; D009508:Nevus, Pigmented / Q000175:diagnosis; D012871:Skin Diseases / Q000145:classification / Q000175:diagnosis*; D012878:Skin Neoplasms / Q000175:diagnosis; D012880:Skin Pigmentation