Palladium-mediated intramolecular carbonylative annulation of o-alkynylphenols to synthesize benzo[b]furo[3,4-d]furan-1-ones.
[reaction in text] The carbonylative annulation of o-alkynylphenols mediated by PdCl(2)(PPh(3))(2) and dppp in the presence of CsOAc at 55 degrees C in acetonitrile under a balloon pressure of CO generates functionalized benzo[b]furo[3,4-d]furan-1-ones in good yields. This novel synthetic approach provides a highly efficient method for diversification of the benzofuran scaffold for combinatorial synthesis.
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Harvard Institute of Chemistry and Cell Biology, Harvard Medical School, 250 Longwood Avenue, SGM 604, Boston, Massachusetts 02115-5731, USA.
Yang
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D001572:Benzofurans / Q000138:chemical synthesis*; D002384:Catalysis; D020650:Combinatorial Chemistry Techniques; D015394:Molecular Structure; D010165:Palladium / Q000737:chemistry; D010636:Phenols / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001572:Benzofurans; D010636:Phenols; D010165:Palladium