title: Marginal zone and B1 B cells unite in the early response against T-independent blood-borne particulate antigens.
abstract: The rate of pathogen elimination determines the extent and consequences of an infection. In this context, the spleen with its highly specialized lymphoid compartments plays a central role in clearing blood-borne pathogens. Splenic marginal zone B cells (MZ), by virtue of their preactivated state and topographical location, join B1 B cells to generate a massive wave of IgM producing plasmablasts in the initial 3 days of a primary response to particulate bacterial antigens. Because of the intensity and rapidity of this response, combined with the types of antibodies produced, splenic MZ and B1 B cells endowed with a "natural memory" provide a bridge between the very early innate and the later appearing adaptive immune response.
authors.affiliation: Division of Developmental and Clinical Immunology, Department of Microbiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
authors.forename: F
authors.initials: F
authors.lastname: Martin
authors.forename: A M
authors.initials: AM
authors.lastname: Oliver
authors.forename: J F
authors.initials: JF
authors.lastname: Kearney
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D016130:Immunophenotyping; D008070:Lipopolysaccharides / Q000276:immunology; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D011509:Proteoglycans / Q000096:biosynthesis; D017464:Receptors, Complement 3d / Q000276:immunology*; D013154:Spleen / Q000166:cytology / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D053667:Syndecans; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011509:Proteoglycans; D017464:Receptors, Complement 3d; D053667:Syndecans