A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L.
[structure in text] From the leaves of Morinda citrifolia, a new unusual iridoid, named citrifolinoside (1), showing significant inhibition of UVB-induced Activator Protein-1 (AP-1) activity in cell cultures, has been isolated. Its structure was elucidated on the basis of detailed high-field 1D and 2D spectral analysis.
Sang
S
S
Department of Food Science and Center for Advanced Food Technology, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901-8520, USA. smsang@hotmail.com
He
K
K
Liu
G
G
Zhu
N
N
Cheng
X
X
Wang
M
M
Zheng
Q
Q
Dong
Z
Z
Ghai
G
G
Rosen
R T
RT
Ho
C T
CT
D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D057888:Iridoid Glucosides; D039823:Iridoids; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry / Q000627:therapeutic use*; D019666:Rubiaceae / Q000737:chemistry / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects*
D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D018808:Transcription Factor AP-1; C428483:citrifolinoside