title: Neuropathogenesis of influenza virus infection in mice.
abstract: The neurovirulent WSN strain of influenza A virus, introduced into the olfactory bulb of C57BL/6 mice, selectively attacks several brain nuclei which are highly implicated in the pathogenesis of neuropsychiatric disturbances. The virus-infected neurons are eradicated through apoptotic neurodegeneration. On the other hand, activated microglia serve the neuroprotection against virus infection.
authors.affiliation: Department of Microbiology, Fukui Medical University School of Medicine, Fukui 910-1193, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Mori
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D017209:Apoptosis; D001921:Brain / Q000473:pathology* / Q000821:virology; D020805:Central Nervous System Viral Diseases / Q000473:pathology* / Q000821:virology; D009980:Influenza A virus; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration; D009474:Neurons / Q000473:pathology / Q000821:virology; D009976:Orthomyxoviridae Infections / Q000473:pathology* / Q000821:virology
chemical_list: D000956:Antigens, Viral