Single nucleotide polymorphism in prohibitin 3' untranslated region and breast-cancer susceptibility.
The RNA encoded by the 3' untranslated region of the prohibitin gene arrests cell proliferation by blocking the transition between the G1 and S phases of the cell cycle. The product of a variant allele (T allele) is inactive. We did a case-control study of prohibitin genotype in 205 women with breast cancer and 1046 healthy controls. The results showed an association between the T allele and breast cancer in women who reported a first-degree relative with the disease (odds ratio 2.5, p=0.005). An even stronger association was found in a subset of women diagnosed at or before age 50 years (4.8, p=0.003). These data suggest that prohibitin genotyping has value in assessing risk of breast cancer in women aged 50 years or younger with at least one first-degree relative with the disease.
Jupe
E R
ER
Badgett
A A
AA
Neas
B R
BR
Craft
M A
MA
Mitchell
D S
DS
Resta
R
R
Mulvihill
J J
JJ
Aston
C E
CE
Thompson
L F
LF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D016022:Case-Control Studies; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008875:Middle Aged; D008969:Molecular Sequence Data; D016017:Odds Ratio; D016133:Polymerase Chain Reaction; D020641:Polymorphism, Single Nucleotide; D011336:Probability; D000091402:Prohibitins; D011506:Proteins / Q000235:genetics*; D012016:Reference Values; D012097:Repressor Proteins; D018570:Risk Assessment; D012680:Sensitivity and Specificity
D000091402:Prohibitins; D011506:Proteins; D012097:Repressor Proteins