Neuronal differentiation: proneural genes inhibit gliogenesis.
Proneural basic helix-loop-helix transcription factors such as Neurogenin are activators of neuronal gene expression. Recent studies show they reinforce neuronal differentiation by also inhibiting the expression of glial genes, and are required in vivo to prevent premature and excessive gliogenesis.
Morrison
S J
SJ
Howard Hughes Medical Institute, Departments of Internal Medicine and Cell and Developmental Biology, 3215 CCGC, University of Michigan, Ann Arbor, Michigan 48109-0934, USA.
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology; D018257:Helix-Loop-Helix Motifs; D009457:Neuroglia / Q000166:cytology*; D009474:Neurons / Q000166:cytology*; D014157:Transcription Factors / Q000502:physiology
D004268:DNA-Binding Proteins; D014157:Transcription Factors