Recovery of erythropoiesis following allogeneic bone marrow transplantation for chronic lymphocytic leukaemia-associated pure red cell aplasia.
Pure red cell aplasia is a rare condition, that can be either idiopathic or associated with a lymphoproliferative disorder. The latter is considered to result from T cell-mediated suppression of haematopoiesis, and usually responds well to treatment with immunosuppressive medication. We describe a patient with B-CLL-associated pure red cell aplasia who did not respond to several courses of immunosuppressive treatment. Erythropoiesis was finally restored after allogeneic bone marrow transplantation.
de Vetten
M P
MP
Department of Hematology, University Hospital Rotterdam/Daniel den Hoed Cancer Center, 3008 AE Rotterdam, Netherlands.
van Gelder
M
M
de Greef
G E
GE
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage; D016026:Bone Marrow Transplantation; D004920:Erythropoiesis / Q000502:physiology*; D006085:Graft Survival; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000628:therapy*; D008297:Male; D012010:Red-Cell Aplasia, Pure / Q000209:etiology / Q000628:therapy*; D014184:Transplantation, Homologous