Lack of utility of intestinal fatty acid binding protein levels in predicting intestinal allograft rejection.
BACKGROUND
The enterocyte-specific protein, intestinal fatty acid binding protein (I-FABP), is detectable in serum only after intestinal injury. Previous studies in animals suggest that I-FABP might be a useful marker of intestinal allograft rejection.


METHODS
I-FABP was repetitively measured in nine intestinal transplant recipients and correlated with findings of surveillance endoscopy.


RESULTS
Average interval between I-FABP determination and biopsy was 3.4 days (SD=4.2 days). Average number of rejection episodes per patient totalled 1.6+/-1.2. General linear modeling demonstrated no tendency for increases in serum FABP to precede histologic graft rejection (P=0.263). Restriction of the analysis to I-FABP determinations 1 day before or on the day of biopsy failed to affect these results. Minor increases in I-FABP were often associated with histologically normal grafts, whereas rejection often occurred when I-FABP was not detectable.


CONCLUSIONS
Serum I-FABP levels do not predict clinical intestinal allograft rejection.
Kaufman
S S
SS
Department of Pediatrics, University of Nebraska Medical Center, Omaha, USA.
Lyden
E R
ER
Marks
W H
WH
Lieberman
J
J
Sudan
D L
DL
Fox
I F
IF
Shaw
B W
BW
Horslen
S P
SP
Langnas
A N
AN
D000328:Adult; D015415:Biomarkers / Q000097:blood / Q000652:urine; D002352:Carrier Proteins / Q000097:blood* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism; D006084:Graft Rejection / Q000097:blood / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D007422:Intestines / Q000473:pathology / Q000637:transplantation*; D008991:Monitoring, Physiologic / Q000379:methods; D009363:Neoplasm Proteins; D015203:Reproducibility of Results; D014184:Transplantation, Homologous / Q000473:pathology / Q000502:physiology*; D025521:Tumor Suppressor Proteins
D015415:Biomarkers; D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins