Amplification of oncogenes revisited: from expression profiling to clinical application.
Regulatory or structural alterations of cellular oncogenes have been implicated in the causation of cancers. Amplification represents one of the major molecular pathways by which gene expression is constitutively enhanced above the level of physiologically normal variation. Consequently, the significance of oncogene amplification in tumorigenesis originally had emerged from expression profiling of tumor cells by oncogene arrays. Amplified oncogenes have been found associated with more aggressive tumor variants and in selected settings are clinical markers to determine patient prognosis.
Savelyeva
L
L
Department of Cytogenetics, H0400, Deutsches Krebsforschungszentrum Im Neuenheimer Feld 280, D-69120 Heidelberg, Germany.
Schwab
M
M
D001943:Breast Neoplasms / Q000175:diagnosis* / Q000235:genetics; D005784:Gene Amplification; D020869:Gene Expression Profiling; D018734:Genes, erbB-2; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D009447:Neuroblastoma / Q000175:diagnosis* / Q000235:genetics; D020411:Oligonucleotide Array Sequence Analysis; D009857:Oncogenes / Q000235:genetics*; D011379:Prognosis
D005819:Genetic Markers