Ruthenium-catalyzed ring-opening and ring-closing enyne metathesis.
[reaction: see text]. When a CH2Cl2 solution of an enyne containing the cycloalkene moiety was stirred in the presence of ruthenium-carbene complex (10 mol %) at room temperature under ethylene gas (1 atm), ring-opening and ring-closing metathesis occurred to afford cyclized triene. The reaction was carried out under argon gas, and no cyclized product was obtained. Enynes with a terminal alkyne gave good results.
Kitamura
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Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Mori
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M
D000475:Alkenes / Q000138:chemical synthesis*; D000480:Alkynes / Q000138:chemical synthesis*; D001128:Argon / Q000737:chemistry; D003516:Cycloparaffins / Q000737:chemistry*; D008956:Models, Chemical; D012428:Ruthenium / Q000737:chemistry*; D013696:Temperature; D013997:Time Factors
D000475:Alkenes; D000480:Alkynes; D003516:Cycloparaffins; D001128:Argon; D012428:Ruthenium