Organ preservation for carcinoma of the larynx and hypopharynx.
Treatment of laryngeal and hypopharyngeal cancers often necessitates total laryngectomy. This article reviews approaches of curing patients with these diseases while preserving their larynx. Strategies include radiation alone, neoadjuvant chemotherapy with radiation for responders, or concurrent chemotherapy and radiation. Both retrospective experiences and randomized trials evaluating differing therapies in an effort to achieve voice preservation are reported and analyzed.
Garden
A S
AS
Department of Radiation Oncology, University of Texas M. D. Anderson Cancer Center, Houston, Texas, USA. agarden@mdanderson.org
D006801:Humans; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000628:therapy*; D007830:Larynx / Q000473:pathology