title: A case of false median cleft of upper lip with IV-A holoprosencephaly that underwent cheiloplasty at 2.5 years of age.
abstract: Holoprosencephaly results from the incomplete development of midline structures within the cerebrum and encompasses a series of abnormalities of mid-facial development. Here, we report a case of male holoprosencephaly associated with false median cleft of upper lip. This patient belonged clinically to the DeMyer's group IV holoprosencephaly, semilobar type. An infant with this type of holoprosencephaly has been thought to die generally within 1 to 2 years after birth and to rarely benefit from an operation. In this case, the patient had cheiloplasty at the age of 2.5 years at the request of his parents and he lives currently, being 3 years and 2 months old.
authors.affiliation: Graduate School, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kobayashi
authors.forename: N
authors.initials: N
authors.lastname: Arai
authors.forename: I
authors.initials: I
authors.lastname: Kiyosaki
authors.forename: N
authors.initials: N
authors.lastname: Uzawa
authors.forename: J
authors.initials: J
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Yoshimasu
authors.forename: T
authors.initials: T
authors.lastname: Amagasa
mesh_terms: D002675:Child, Preschool; D002971:Cleft Lip / Q000601:surgery*; D005145:Face / Q000002:abnormalities; D005500:Follow-Up Studies; D016142:Holoprosencephaly / Q000145:classification*; D006801:Humans; D006972:Hypertelorism / Q000473:pathology; D008607:Intellectual Disability / Q000473:pathology; D008046:Lip / Q000601:surgery*; D008297:Male; D009300:Nasal Septum / Q000002:abnormalities