title: Do intraoral radial forearm free flaps re-mucosalise and is candida infection relevant?
abstract: Eleven patients, with a mean age of 57 years, who had undergone radial forearm flap reconstruction following the excision of intraoral carcinoma, underwent flap biopsy at a mean of 45 months postoperatively. Seven of the patients had received postoperative radiotherapy. In eight patients the clinical appearance of the flap was similar in colour to that of adjacent normal oral mucosa; the remaining flaps retained the appearance of normal volar forearm skin. Histological examination of the flaps showed varying degrees of telangiectasia and mild chronic inflammation. In only two patients was superficial infection by candida hyphae identified. Intraoral free flaps, although clinically resembling oral mucosa, retain histological features of skin, at least within the period under study. The erythematous clinical appearance was not correlated with the presence of chronic fungal infection, but reflected the presence of vascular repair tissue, telangiectasia and mild residual chronic inflammation.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Royal Victoria Infirmary, Dental School, University of Newcastle-upon-Tyne, Newcastle-upon-Tyne, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Khan
authors.forename: D J
authors.initials: DJ
authors.lastname: Cloke
authors.forename: P D
authors.initials: PD
authors.lastname: Hodgkinson
authors.forename: N R
authors.initials: NR
authors.lastname: McLean
authors.forename: J V
authors.initials: JV
authors.lastname: Soames
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods; D002180:Candidiasis, Oral / Q000150:complications* / Q000473:pathology; D016022:Case-Control Studies; D002908:Chronic Disease; D004890:Erythema / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000209:etiology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa; D009062:Mouth Neoplasms / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant / Q000379:methods; D012189:Retrospective Studies; D013524:Surgical Flaps / Q000473:pathology*; D013684:Telangiectasis / Q000209:etiology / Q000473:pathology