[Evolutionary aspects of protein structure and folding].
Four basic stages of evolution of protein structure are described based on recent work of the authors targeted specifically on reconstruction of the earliest events in the protein evolution. According to this reconstruction, the initial stage of short peptides of, probably, only few amino-acid residues had been followed by formation of closed loops of the size 25-30 residues, which corresponds to the polymer-statistically optimal ring closure size for mixed polypeptide chains. The next stage involved fusion of the respective small linear genes and formation of protein structures consisting of several closed loops of the nearly standard size, up to 4-6 loops (100-200 amino acid residues) in a typical protein fold. The last, modern stage began with combinatorial fusion of the presumably circular 300-600 bp DNA units and, accordingly, formation of multidomain proteins.
Berezovskiĭ
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IN
Department of Structural Biology, Weizmann Institute of Science, Rehovot, 76100, Israel. Igor.Berezovsky@weizmann.ac.il
Trifonov
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EN
D000818:Animals; D019143:Evolution, Molecular; D006801:Humans; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry / Q000235:genetics
D011506:Proteins