title: Synthesis and hydrolytic stability studies of albendazole carrier prodrugs.
abstract: Three N-acyl (2, 3, and 4), two N-alkoxycarbonyl (5 and 6), and one N-acyloxymethyl (7) derivatives of albendazole (1) have been prepared and assessed as potential prodrugs. The determination of the aqueous solubility and partition coefficient, as well as the conversion of these derivatives to 1 in buffer solution, human plasma, and pig liver esterase were determined.
authors.affiliation: Departamento de Farmacia, Facultad de Química, UNAM, C.U. D.F. 04510, Mexico, Mexico. franher@servidor.unam.mx
authors.forename: F
authors.initials: F
authors.lastname: Hernández-Luis
authors.forename: A
authors.initials: A
authors.lastname: Hernández-Campos
authors.forename: L
authors.initials: L
authors.lastname: Yépez-Mulia
authors.forename: R
authors.initials: R
authors.lastname: Cedillo
authors.forename: R
authors.initials: R
authors.lastname: Castillo
mesh_terms: D015766:Albendazole / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D011355:Prodrugs / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012995:Solubility; D014867:Water / Q000737:chemistry
chemical_list: D000871:Anthelmintics; D011355:Prodrugs; D014867:Water; D015766:Albendazole