title: Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated.
abstract: The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte invasion. Here we described a member of the gene family found in P. falciparum (PfRH3) that is transcribed in its entirety, under stage-specific control, with correct splicing of the intron, but appears not to be translated, probably due to two reading frameshifts at the 5' end of the gene.
authors.affiliation: National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom. htaylor@nimr.mrc.ac.uk
authors.forename: H M
authors.initials: HM
authors.lastname: Taylor
authors.forename: T
authors.initials: T
authors.lastname: Triglia
authors.forename: J
authors.initials: J
authors.lastname: Thompson
authors.forename: M
authors.initials: M
authors.lastname: Sajid
authors.forename: R
authors.initials: R
authors.lastname: Fowler
authors.forename: M E
authors.initials: ME
authors.lastname: Wickham
authors.forename: A F
authors.initials: AF
authors.lastname: Cowman
authors.forename: A A
authors.initials: AA
authors.lastname: Holder
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002448:Cell Adhesion; D002875:Chromosomes; D016368:Frameshift Mutation; D017125:Genes, Protozoan / Q000235:genetics*; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000235:genetics* / Q000254:growth & development; D010966:Plasmodium vivax / Q000235:genetics; D010967:Plasmodium yoelii / Q000235:genetics; D014176:Protein Biosynthesis; D015800:Protozoan Proteins / Q000235:genetics* / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014158:Transcription, Genetic
chemical_list: D015800:Protozoan Proteins