title: Fatal disseminated fusarium infection in acute lymphoblastic leukaemia in complete remission.
abstract: Fusarium species are increasingly recognised as serious pathogens in the immunocompromised. The outcome in the context of persistent severe neutropenia has been almost universally fatal. However, there have been several case reports of successful treatment if neutrophil recovery can be achieved. This report presents the case of a fatality that occurred despite neutrophil recovery. A 67 year old man developed disseminated fusariosis during the neutropenic phase of induction chemotherapy for acute lymphoblastic leukaemia. Fusarium dimerum was isolated from blood cultures. This species is highly unusual and very few case reports exist in the literature. An initial response to amphotericin treatment coincided with neutrophil recovery but a subsequent relapse occurred, despite adequate neutrophil counts, which proved fatal. It is postulated that reseeding of the blood from an occult site, namely the right vitreum in this case, led to this secondary relapse despite achieving complete leukaemic remission.
authors.affiliation: Department of Haematology, Southampton General Hospital, Tremona Road, Southampton S016 6YD, UK. Belindadoc@aol.com
authors.forename: B
authors.initials: B
authors.lastname: Austen
authors.forename: H
authors.initials: H
authors.lastname: McCarthy
authors.forename: B
authors.initials: B
authors.lastname: Wilkins
authors.forename: A
authors.initials: A
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Duncombe
mesh_terms: D000368:Aged; D017809:Fatal Outcome; D005670:Fusarium; D006801:Humans; D016867:Immunocompromised Host; D008297:Male; D009181:Mycoses / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D009503:Neutropenia / Q000139:chemically induced / Q000276:immunology; D009894:Opportunistic Infections / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000276:immunology