17 beta-estradiol protects neurons from ischemic damage and attenuates accumulation of extracellular excitatory amino acids.
We studied the effect of 17 beta-estradiol on ischemia-induced increases in extracellular amino acids (aspartate, glutamate, glycine, and taurine) in the gerbil hippocampal CA1 region by a microdialysis-high-performance liquid chromatography system in vivo. Transient forebrain ischemia for 3 min produced a marked accumulation of aspartate, glutamate, taurine, and glycine (498%, 410%, 266%, and 178%, respectively). 17 beta-estradiol reduced the increase of aspartate and glutamate by 57% and 53% of the peak values. This finding suggests that 17 beta-estradiol may protect neurons against ischemic damage by attenuating the ischemia-induced increase in extracellular excitatory amino acids.
Chen
J
J
Department of Anesthesiology, Shanghai Changning Center Hospital, China. chenjf@81890.net
Xu
W
W
Jiang
H
H
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D017536:Carotid Artery, Common / Q000502:physiology; D002851:Chromatography, High Pressure Liquid; D004958:Estradiol / Q000494:pharmacology*; D018846:Excitatory Amino Acids / Q000378:metabolism*; D005849:Gerbillinae; D006624:Hippocampus / Q000473:pathology; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000473:pathology*; D008297:Male; D017551:Microdialysis; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*; D018696:Neuroprotective Agents / Q000494:pharmacology*; D017966:Pyramidal Cells / Q000187:drug effects / Q000378:metabolism / Q000473:pathology
D018846:Excitatory Amino Acids; D018696:Neuroprotective Agents; D004958:Estradiol