[Identification of RNA modification enzymes using sequence homology].
Modified nucleotides possessing diverse chemical structures are universally present in all cell RNAs. Their formation is a posttranscriptional process catalyzed by various RNA modification enzymes. Despite the large body of data concerning the localization of modified nucleotides in different RNAs, the enzymes involved in their biosynthesis remain largely unknown. In this review we discuss the recent achievements in application of the sequence homology approach to searching for and identifying RNA modification enzymes such as RNA-pseudouridine synthases, RNA-methyltransferases, and RNA-inosine synthases (adenosine deaminases).
Ansmant
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Laboratoire de Maturation des ARN et Enzymologie Moleculaire, UMR 7567 CNRS-UHP Nancy I, Faculte des Sciences, BP 239, 54506 Vandoeurve-les-Nancy, France.
Motorin
Iu
Iu
D000818:Animals; D004798:Enzymes / Q000032:analysis / Q000235:genetics*; D016678:Genome; D006801:Humans; D012313:RNA / Q000235:genetics*; D017421:Sequence Analysis; D017385:Sequence Homology
D004798:Enzymes; D012313:RNA