The calciuric response to dietary salt of Dahl salt-sensitive and salt-resistant male rats.
BACKGROUND
There are conflicting reports regarding the effect of salt sensitivity on the calciuric response to salt, perhaps because of gender differences and different modes of salt administration. We tested the hypothesis that the calciuric response to dietary salt would not differ for male Dahl salt-sensitive (S) and salt-resistant (R) rats.


METHODS
S and R rats were fed high- (80 g/kg) or low- (3 g/kg) salt diets for 3 weeks and urine (24 hour) was collected weekly.


RESULTS
Urinary calcium excretion was up to 20-fold greater for S and R rats fed a high-salt diet (P < 0.001) than for S and R rats fed a low-salt diet and did not differ significantly between S and R rats. S rats, however, excreted calcium in significantly higher urine volumes (P< 0.001) during high salt intake and developed hypertension. Plasma parathyroid hormone concentrations of S and R rats did not differ during low salt intake and increased significantly to the same concentration after 3 weeks of high salt intake.


CONCLUSIONS
We have previously reported that plasma 25-hydroxyvitamin D and 24,25-dihydroxyvitamin D concentrations of male S rats, but not male R rats, were drastically reduced by 3 weeks of high salt intake. These data suggest that salt-induced hypertension and salt-induced alterations in the vitamin D endocrine system of male S rats do not affect the calciuric response to dietary salt.
Thierry-Palmer
M
M
Department of Biochemistry, Morehouse School of Medicine, Atlanta, Georgia 30310-1495, USA. thierrm@msm.edu
Sherman
D D
DD
Emmett
N L
NL
Wang
M
M
Bayorh
M A
MA
Donkoh
N
N
D000818:Animals; D002118:Calcium / Q000652:urine*; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D051381:Rats; D020303:Rats, Inbred Dahl; D012964:Sodium / Q000652:urine; D012982:Sodium, Dietary / Q000494:pharmacology*
D010281:Parathyroid Hormone; D012982:Sodium, Dietary; D012964:Sodium; D002118:Calcium