DXS101: a highly polymorphic X-linked STR.
This paper presents sequence and population genetic data for the microsatellite marker DXS101 which is a highly polymorphic X-linked trinucleotide polymorphism with 18 alleles 179-233 bp in length. A polymorphism information content (PIC) of 0.884 and a mean exclusion chance (MEC) of 0.879 were obtained by analysing a Caucasian population sample. A deviation from the Hardy-Weinberg equilibrium (HWE) could not be detected. Kinship tests revealed a typical X-linked inheritance and no mutations were found in 340 meioses. DXS101 is located 104.9-121 cM from the Xp-telomere (Xp-tel) corresponding to Xq21.33-Xq22.3. Concomitant testing of DXS101 and DXS6807 is possible as these two markers are unlinked. The data presented qualify this X-linked microsatellite marker as a useful tool for forensic purposes.
Edelmann
J
J
Institute of Legal Medicine, University of Leipzig, Johannisallee 28, 04103 Leipzig, Germany. edej@server3.medizin.uni-leipzig.de
Szibor
R
R
D002648:Child; D002874:Chromosome Mapping; D016172:DNA Fingerprinting; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D005858:Germany; D006801:Humans; D008297:Male; D010334:Paternity; D011110:Polymorphism, Genetic; D018911:Trinucleotide Repeats; D044465:White People / Q000235:genetics; D014960:X Chromosome