title: Complexes of Ni(II) and Cu(II) with ofloxacin. Crystal structure of a new Cu(II) ofloxacin complex.
abstract: Several coordination compounds formed between Ni(II) or Cu(II) with ofloxacin have been synthesised and characterised. According to elemental chemical analysis and FT-IR spectroscopy data, direct reaction of Ni(II) and Cu(II) salts with ofloxacin leads to formation of precipitates for which mass spectrometry demonstrates their polymeric nature. However, crystalline [Cu(oflo)2(H2O)].2H2O is formed if the reaction is carried out in the presence of ammonia. This complex crystallises in the triclinic system, space group P-1 with a=9.2887(12), b=11.2376(14), c=17.874(2) A, alpha=92.12(3), beta=95.39(3), gamma=91.71(3) degrees and Z=2. The local geometry around the Cu(II) ion is a slightly distorted square base pyramid. Electronic spectra, magnetic susceptibility measurements and EPR spectra of the synthesised complexes indicate a tetragonal environment.
authors.affiliation: Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Salamanca, Spain. bmacias@gugu.usal.es
authors.forename: B
authors.initials: B
authors.lastname: Macías
authors.forename: M V
authors.initials: MV
authors.lastname: Villa
authors.forename: I
authors.initials: I
authors.lastname: Rubio
authors.forename: A
authors.initials: A
authors.lastname: Castiñeiras
authors.forename: J
authors.initials: J
authors.lastname: Borrás
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry / Q000378:metabolism; D000892:Anti-Infective Agents, Urinary / Q000737:chemistry / Q000378:metabolism; D003300:Copper / Q000378:metabolism*; D003460:Crystallization; D018360:Crystallography, X-Ray; D013058:Mass Spectrometry; D015394:Molecular Structure; D009532:Nickel / Q000378:metabolism*; D015242:Ofloxacin / Q000737:chemistry* / Q000378:metabolism*; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D000890:Anti-Infective Agents; D000892:Anti-Infective Agents, Urinary; D003300:Copper; D009532:Nickel; D015242:Ofloxacin