Suicide through doxylamine poisoning.
Doxylamine is an antihistamine of the ethanolamine class. It is used primarily as a sleep-inducing agent. Only a few reports can be found in the literature about lethal intoxications with doxylamine, but many with combined intoxications. Doxylamine is, aside from diphenhydramine, the only chemically defined active ingredient in some sleeping medications which is available without a prescription in the Federal Republic of Germany. Two cases of doxylamine poisoning are presented, in which high doxylamine concentrations were found in the blood and organs.
Bockholdt
B
B
Institute of Legal Medicine, UK Benjamin Franklin, Free University, Hittorfstr. 18, D-14195, Berlin, Germany. bboc@zedat.fu-berlin.de
Klug
E
E
Schneider
V
V
D001344:Autopsy; D004319:Doxylamine / Q000032:analysis / Q000378:metabolism / Q000506:poisoning*; D017809:Fatal Outcome; D005260:Female; D005860:Germany, West; D006634:Histamine H1 Antagonists / Q000032:analysis / Q000378:metabolism / Q000506:poisoning*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000032:analysis / Q000378:metabolism / Q000506:poisoning*; D008099:Liver / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000506:poisoning; D013405:Suicide
D006634:Histamine H1 Antagonists; D006993:Hypnotics and Sedatives; D004366:Nonprescription Drugs; D004319:Doxylamine