Apolipoprotein E genotyping in a sample of Colombian patients with Alzheimer's disease.
Apolipoprotein E e4 (APOEe4) allele has been associated with an increased risk for Alzheimer's disease (AD) in diverse populations. Few studies have been carried out in Hispano-Americans and results are inconclusive due to ethnic diversity. This study determined the frequency of APOE alleles in a group of 61 Caucasian-Mestizos patients with probable AD, and 61 age- and sex-matched controls. APOEe4 frequency was 36.8% for patients, and 8.2% for controls (P < 0.0001; OR 7.6). Genotype frequencies differ between the two groups (P < 0.0001). Genotype 3/3 was the most common. Frequency of genotypes 3/4, 4/4 and 2/4 were higher in patients than in the controls. Our results show a highly significant association of APOEe4 with AD, and implies the importance of APOEe4 as a risk factor in this population.
Arboleda
G H
GH
Genetics Institute, Faculty of Medicine, Universidad Nacional de Colombia, Bogota, Colombia. gonzalo.arboleda@stud.man.ac.uk
Yunis
J J
JJ
Pardo
R
R
Gómez
C M
CM
Hedmont
D
D
Arango
G
G
Arboleda
H
H
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D016022:Case-Control Studies; D015331:Cohort Studies; D003105:Colombia; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006630:Hispanic or Latino / Q000235:genetics; D006801:Humans; D007199:Indians, South American / Q000235:genetics; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D044465:White People / Q000235:genetics
D053327:Apolipoprotein E4; D001057:Apolipoproteins E