Nitric oxide and tissue destruction.
Nitric oxide (NO) is a free radical which has complex roles in both health and disease. It is now recognized that NO is essential for a vast spectrum of intracellular and extracellular events in a wide variety of tissues. NO has also been implicated in the pathogenesis of numerous inflammatory and autoimmune diseases. In this review we consider the roles of NO generally and in particular the implications for periodontal diseases.
Kendall
H K
HK
University of Queensland, Department of Dentistry, 200 Turbot Street, Brisbane, QLD 4000, Australia.
Marshall
R I
RI
Bartold
P M
PM
D000818:Animals; D004249:DNA Damage; D016166:Free Radical Scavengers; D006706:Homeostasis; D006801:Humans; D018375:Neutrophil Activation; D009569:Nitric Oxide / Q000502:physiology*; D010518:Periodontitis / Q000378:metabolism; D015290:Second Messenger Systems; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
D016166:Free Radical Scavengers; D009569:Nitric Oxide