title: [Analysis of chromosome instability as a genetic risk factor of laryngeal cancer].
abstract: The bleomycin test was established in the laboratory of Hsu et al. (M.D. Anderson Cancer Center, Houston, Texas) for quantitative estimation of hidden chromosome instability. The article presents a concept, method and applicability of the test. Chromosome sensitivity initially studied in respect to estimate a general genetic risk to develop cancer was found as a technique of an extended potential to study a genetic risk of familial cancer, young adults & neck cancer and other associations.
authors.affiliation: Klinika Otolaryngologii AM im. K. Marcinkowskiego w Poznaniu.
authors.forename: P
authors.initials: P
authors.lastname: Dabrowski
authors.forename: K
authors.initials: K
authors.lastname: Szyfter
mesh_terms: D001761:Bleomycin / Q000494:pharmacology; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D002873:Chromosome Fragility / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics*; D009152:Mutagenicity Tests; D012307:Risk Factors
chemical_list: D001761:Bleomycin