title: Neuropsychiatric lupus.
abstract: Neuropsychiatric (NP) manifestations of systemic lupus erythematosus (SLE) have been recognized for more than 100 years but continue to pose a diagnostic and therapeutic challenge for rheumatologists and other physicians involved in the care of SLE patients. NP-SLE includes a plethora of clinical manifestations and the reported prevalence has varied widely between 14% and 75%. The recent introduction of a standard nomenclature, case definitions, and diagnostic criteria for 19 NP-SLE syndromes should facilitate a more consistent approach to the classification of patients and to the execution of large multicenter clinical studies. The etiology of NP-SLE is likely multifactorial and includes microangiopathy, autoantibody production, and the intrathecal production of proinflammatory cytokines. Newer imaging modalities of brain structure and function provide novel ways of understanding pathogenic mechanisms. The use of standardized neuropsychometric techniques to evaluate cognitive function has identified a high prevalence of cognitive impairment in SLE patients. The management of patients with NP-SLE includes symptomatic and immunosuppressive therapies, evidence for which is largely limited to uncontrolled clinical trials and anecdotal experience. Multicenter initiatives are required to address important issues on prognosis and management.
authors.affiliation: Division of Rheumatology, Queen Elizabeth II Health Sciences Center, 310 Bethune Building, Halifax, Nova Scotia, B3H 2Y9, Canada. jhanly@is.dal.ca
authors.forename: J G
authors.initials: JG
authors.lastname: Hanly
mesh_terms: D003072:Cognition Disorders / Q000175:diagnosis; D006801:Humans; D020945:Lupus Vasculitis, Central Nervous System / Q000145:classification / Q000175:diagnosis / Q000503:physiopathology / Q000628:therapy; D009483:Neuropsychological Tests; D011379:Prognosis