Reemergence of gentamicin-susceptible strains of methicillin-resistant Staphylococcus aureus in France: a phylogenetic approach.
The reemergence of gentamicin-susceptible (Gen(s)) methicillin-resistant Staphylococcus aureus (MRSA) isolates in France between 1992 and 1996 was investigated using a phylogenetic approach (multiprimer randomly amplified polymorphic DNA typing). Eighty-six percent (65 of 85) of the French strains were grouped into one phylogenetic cluster within which all but one Gen(s) strain were grouped into a subcluster. Thus, the reemergence of Gen(s) MRSA strains in France was likely due to the spread of one specific clone which belonged to a cluster comprising most French gentamicin-resistant (Gen(r)) strains. This suggests that the Gen(s) clone has emerged from a Gen(r) strain of this cluster.
Blanc
D S
DS
Division autonome de médecine préventive hospitalière, CHU Vaudois, 1011 Lausanne, Switzerland. Dominique.Blanc@chuv.hospvd.ch
Francioli
P
P
Le Coustumier
A
A
Gazagne
L
L
Lecaillon
E
E
Gueudet
P
P
Vandenesch
F
F
Etienne
J
J
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D016521:Electrophoresis, Gel, Pulsed-Field; D005602:France / Q000453:epidemiology; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D016106:Methicillin Resistance; D010802:Phylogeny; D019105:Random Amplified Polymorphic DNA Technique; D013203:Staphylococcal Infections / Q000453:epidemiology* / Q000382:microbiology; D013211:Staphylococcus aureus / Q000145:classification / Q000187:drug effects* / Q000235:genetics
D000900:Anti-Bacterial Agents; D005839:Gentamicins