title: Synthesis of GLA-60 type pyran carboxylic acids with an alkyl chain instead of an ester chain as LPS-antagonists.
abstract: Synthesis of GLA-60 type pyran carboxylic acid analogues with an alkyl chain instead of an ester chain and their LPS-antagonist activity toward human U937 cells are described.
authors.affiliation: Exploratory Chemistry Research Laboratories, Sankyo Co. Ltd., Hiromachi 1-2-58, Shinagawa-ku, 140-8710, Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Shiozaki
authors.forename: S
authors.initials: S
authors.lastname: Kanai
authors.forename: S
authors.initials: S
authors.lastname: Kurakata
authors.forename: M
authors.initials: M
authors.lastname: Nishijima
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis; D002264:Carboxylic Acids / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D006801:Humans; D020128:Inhibitory Concentration 50; D008050:Lipid A / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D011714:Pyrans / Q000737:chemistry; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000187:drug effects; D020298:U937 Cells
chemical_list: D000276:Adjuvants, Immunologic; D002264:Carboxylic Acids; D008050:Lipid A; D008070:Lipopolysaccharides; D011714:Pyrans; D014409:Tumor Necrosis Factor-alpha; C056260:GLA 60