[Murine models for human diseases].
This article is a bibliographic review concerning mouse mutations, spontaneous, induced or genetically engineered, as models of human genetic diseases. Since the beginning of the last century, mouse models have been instrumental in the understanding of the pathogenesis of many diseases and designing of new therapies. A number of recent technological advances in embryo manipulation and many large-scale mutagenesis screens will dramatically increase the availability of new mouse models in the near future. In the "post-genomic" era, mouse mutants will have a significant role as a model system for functional genome analysis of the upcoming whole-genome information of the human and mouse genomes projects.
Benavides
F
F
Department of Carcinogenesis, Science Park, M.D. Anderson Cancer Center, University of Texas, Park Road 1C, P.O. Box 389, Smithville, Texas 78957, USA. fbenavides@sprd1.mdacc.tmc.edu
Guénet
J L
JL
D000818:Animals; D000830:Animals, Laboratory / Q000235:genetics*; D004195:Disease Models, Animal; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D015894:Genome, Human; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation; D051381:Rats