Resveratrol suppresses hepatoma cell invasion independently of its anti-proliferative action.
Resveratrol, found in grapes, is a phytoalexin with antioxidative activity. The compound (100 and 200 microM) inhibited the proliferation of hepatoma cells, although this phytoalexin exerted little influence up to 50 microM. Resveratrol, however, suppressed the invasion of the hepatoma cells even at a concentration of 25 microM. Sera from rats orally given resveratrol restrained only the invasion of AH109A cells. Resveratrol and resveratrol-loaded rat serum suppressed reactive oxygen species-potentiated invasive capacity. These results suggest that the anti-invasive activity of resveratrol is independent of the anti-proliferative activity, and that the antioxidative property of resveratrol may be involved in its anti-invasive action.
Kozuki
Y
Y
Department of Applied Biological Science, Tokyo Noko University, Saiwaicho 3-5-8, Fuchu, Tokyo 183-8509, Japan.
Miura
Y
Y
Yagasaki
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D006528:Carcinoma, Hepatocellular / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D019271:Hypoxanthine / Q000494:pharmacology; D008113:Liver Neoplasms / Q000473:pathology*; D009361:Neoplasm Invasiveness; D051381:Rats; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D014969:Xanthine Oxidase / Q000494:pharmacology
D000970:Antineoplastic Agents; D000975:Antioxidants; D013267:Stilbenes; D019271:Hypoxanthine; D014969:Xanthine Oxidase; D000077185:Resveratrol