Measles immunity in HIV-infected children.
In a retrospective study, sera from 84 children of human immunodeficiency virus (HIV)-seropositive mothers (35 HIV-infected and 49 uninfected children) with a known date of receipt of measles, mumps, and rubella vaccine were tested for antibody to measles vaccine by an indirect enzyme immunoassay (EIA) method and/or microneutralization (NEUT). At the time of last measurement, 21/35 (60.0%) HIV-infected children remained seropositive by either EIA or NEUT. Forty seven of forty-nine (95.9%) uninfected children had evidence of measles antibody. Six HIV-infected children had a documented loss of antibody over time. The majority of HIV-infected children had antibody to measles vaccine virus, which in some cases decreased over time.
Walter
E B
EB
Department of Pediatrics, Duke University Medical Center, Durham, North Carolina, USA.
Katz
S L
SL
Bellini
W J
WJ
D000914:Antibodies, Viral / Q000032:analysis*; D015658:HIV Infections / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007124:Immunoenzyme Techniques; D007223:Infant; D008458:Measles Vaccine / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine / Q000276:immunology; D009500:Neutralization Tests; D012189:Retrospective Studies; D012411:Rubella Vaccine / Q000276:immunology; D017778:Vaccines, Combined / Q000276:immunology
D000914:Antibodies, Viral; D008458:Measles Vaccine; D022542:Measles-Mumps-Rubella Vaccine; D009108:Mumps Vaccine; D012411:Rubella Vaccine; D017778:Vaccines, Combined