The amplification of TCR signaling by dynamic membrane microdomains.
Modulation of T-cell receptor (TCR) signaling is essential for the regulation of T-cell responses to infectious agents. Recently, many laboratories have suggested that TCR triggering might be compartmentalized in plasma membrane microdomains called rafts. Results on the role of lipid rafts as signaling units in TCR triggering suggest that rafts might be used by T cells to fine-tune their immune responsiveness.
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Dept of Biomedical Sciences, University of Padova, via G. Colombo 3, 35121, Padova, Italy. aviola@civ.unipd.it
D000818:Animals; D018106:CD28 Antigens / Q000502:physiology; D006801:Humans; D018448:Models, Immunological; D011948:Receptors, Antigen, T-Cell / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology
D018106:CD28 Antigens; D011948:Receptors, Antigen, T-Cell