title: Changes in profiles of circulating insulin-like growth factor components during hormone replacement therapy according to the responsiveness to therapy in postmenopausal women.
abstract: OBJECTIVE
  Objectives of this study were (1) to evaluate the changes in the profiles of circulating insulin-like growth factor and of insulin-like growth factor-binding proteins during hormone replacement therapy and their relation with responsiveness to hormone replacement therapy and (2) to investigate the relationship between the changes in these insulin-like growth factor components and the annual changes in bone mineral density in postmenopausal women.
  
  
  METHODS
  Insulin-like growth factor and insulin-like growth factor-binding proteins were measured by immunoradiometric assay and Western ligand blotting in sera from 39 postmenopausal women treated with sequential hormone replacement therapy for 1 year. Bone mineral density at the lumbar spine and the proximal portion of the femur was determined by dual-energy x-ray absorptiometry.
  
  
  RESULTS
  No significant change in the serum levels of insulin-like growth factor II and insulin-like growth factor-binding protein was noted during hormone replacement therapy in either the responders to therapy or the nonresponders (women with >3% bone loss per year), but serum levels of insulin-like growth factor I and proportions of insulin-like growth factor-binding proteins 1, 2, and 4 decreased during hormone replacement therapy only in the former group. Changes in insulin-like growth factor components during hormone replacement therapy did not correlate with annual bone mineral density changes.
  
  
  CONCLUSIONS
  Profiles of circulating insulin-like growth factor I and insulin-like growth factor-binding proteins might be involved in responsiveness to hormone replacement therapy, but changes in these components during hormone replacement therapy do not predict annual changes in bone mineral density.
authors.affiliation: Department of Obstetrics and Gynecology, Seoul National University College of Medicine, Korea.
authors.forename: J G
authors.initials: JG
authors.lastname: Kim
authors.forename: J Y
authors.initials: JY
authors.lastname: Lee
mesh_terms: D015502:Absorptiometry, Photon; D015519:Bone Density; D015914:Estrogen Replacement Therapy; D005260:Female; D005269:Femur / Q000378:metabolism; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000097:blood; D008161:Lumbosacral Region; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood*; D013002:Somatomedins / Q000032:analysis*; D013131:Spine / Q000378:metabolism
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins