Aspergillus laryngotracheobronchial infection in a 6-year-old girl following bone marrow transplantation.
Localised fungal infection of the larynx and tracheobronchial tree is extremely uncommon. We report the case of a 6-year-old girl with acute lymphocytic leukaemia, who developed symptoms of upper airways obstruction 6 months after a cord blood transplant. Bronchoscopy showed a pale plaque lesion in the larynx and tracheobronchial tree. Aspergillus fumigatus was cultured from a biopsy of the lesion. The patient was treated successfully with a prolonged course of amphotericin B and assessed with multiple surveillance bronchoscopies.
Barnes
C
C
Royal Children's Hospital, Melbourne, Australia.
Berkowitz
R
R
Curtis
N
N
Waters
K
K
D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000188:drug therapy; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D001706:Biopsy; D016026:Bone Marrow Transplantation; D001991:Bronchitis / Q000188:drug therapy / Q000382:microbiology*; D002648:Child; D005260:Female; D006801:Humans; D007827:Laryngitis / Q000188:drug therapy / Q000382:microbiology*; D007830:Larynx / Q000382:microbiology / Q000473:pathology; D011183:Postoperative Complications; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D012141:Respiratory Tract Infections / Q000382:microbiology; D014136:Tracheitis / Q000188:drug therapy / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D000666:Amphotericin B