title: Effects of transmyocardial revascularization on myocardial perfusion and systolic function assessed by nuclear and magnetic resonance imaging methods.
abstract: OBJECTIVE
  There is no obvious explanation, except placebo, to the symptomatic effect of transmyocardial laser revascularization (TMR) in patients with refractory angina. Whether TMR improves myocardial perfusion or relieves symptoms without altering cardiac function is not clarified.
  
  
  METHODS
  One hundred patients with refractory angina were randomized 1:1 to TMR (CO2 laser) and medical treatment, or medical treatment alone. Technetium 99m (99mTc)-tetrofosmin myocardial perfusion tomography (SPECT), quantitative myocardial perfusion gated SPECT (QGSPECT), technetium 99m (99mTc) multiple gated acquisition radionuclide ventriculografi (MUGA) and cine-magnetic resonance imaging (cine-MRI) were performed at baseline and after 3 and 12 months.
  
  
  RESULTS
  Following TMR, a slight reduction in left ventricular ejection fraction (LVEF) (p < 0.05) was observed (MUGA and QGSPECT) compared to baseline. Inclusion of incomplete studies (QGSPECT) revealed a significant reduction in LVEF and increase in left ventricular end-diastolic volume (LVEDV) (p < 0.05) compared to a control group. Otherwise, no between-group comparisons showed statistically significant differences.
  
  
  CONCLUSIONS
  TMR did not improve myocardial perfusion, but led to a reduction in LVEF and increase in LVEDV, however not significantly different from the control group.
authors.affiliation: Department of Cardiology, The National Hospital, University of Oslo, Norway. laaaberg@online.no
authors.forename: L
authors.initials: L
authors.lastname: Aaberge
authors.forename: K
authors.initials: K
authors.lastname: Rootwelt
authors.forename: H J
authors.initials: HJ
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Nordstrand
authors.forename: K
authors.initials: K
authors.lastname: Forfang
mesh_terms: D000368:Aged; D000787:Angina Pectoris / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery*; D002306:Cardiac Volume / Q000502:physiology; D003326:Coronary Circulation / Q000502:physiology*; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D019028:Magnetic Resonance Imaging, Cine; D008297:Male; D008875:Middle Aged; D009204:Myocardial Revascularization; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; D013599:Systole / Q000502:physiology*; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology
chemical_list: D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin