DNA replication: building the perfect switch.
A sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.
Diffley
J F
JF
ICRF Clare Hall Laboratories, South Mimms, EN6 3LD, UK. J.Diffley@icrf.icnet.uk
D000818:Animals; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D004261:DNA Replication; D015894:Genome, Human; D006801:Humans
D018844:Cyclin-Dependent Kinases