New anti-influenza agents, FR198248 and its derivatives. II. Characterization of FR198248, its related compounds and some derivatives.
We isolated FR198248 from the cultured broth of Aspergillus terreus No. 13830 as a new anti-influenza agents. The structure of FR198248 was elucidated by several spectroscopic experiments as a novel tetrahydroxybenzaldehyde compound. Furthermore, we described the characteristics of FR198248, its related compounds and some derivatives.
Nishihara
Y
Y
Fermentation Development Laboratories, Fujisawa Pharmaceutical Co, Ltd, Aichi, Japan. Yutaka_Nishihara@po.fujisawa.co.jp
Takase
S
S
Tsujii
E
E
Hatanaka
H
H
Hashimoto
S
S
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001230:Aspergillus / Q000737:chemistry; D001572:Benzofurans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009975:Orthomyxoviridae / Q000187:drug effects*; D013055:Spectrophotometry, Infrared
D000998:Antiviral Agents; D001572:Benzofurans; C424923:FR 198248