Update on the role of leukotrienes in the pathogenesis of atopy: a comparative review.
The pathogenesis of atopic disease (AD) is controversial in humans and dogs. In humans, leukotrienes (LT) are thought to play an important role in this disease and LT inhibitors are commonly used as treatment for AD. Leukotrienes are a heterogeneous group of biologically active compounds that mediate many aspects of inflammatory and allergic reactions. This paper will review the role of LT in atopic disease in a comparative manner. Leukotriene inhibitors and their therapeutic use in the management of atopic disease in humans and dogs are discussed.
Marsella
R
R
Department of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Florida, PO Box 100126, Gainesville, FL 32610-126, USA. MarsellaR@mail.vetmed.ufl.edu
D000818:Animals; D003876:Dermatitis, Atopic / Q000209:etiology / Q000276:immunology / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology* / Q000276:immunology* / Q000517:prevention & control; D004285:Dogs; D006801:Humans; D020024:Leukotriene Antagonists; D015289:Leukotrienes / Q000378:metabolism*
D020024:Leukotriene Antagonists; D015289:Leukotrienes