[Angiotension I converting enzyme gene polymorphism in Chinese patients with obstructive sleep apnea syndrome].
OBJECTIVE
To investigate the relationship of an insertion/deletion (I/D) polymorphism of the angiotension-converting enzyme (ACE) gene to obstructive sleep apnea syndrome (OSAS).


METHODS
Genomic DNA was extracted from blood samples and amplified by polymerase chain reaction (PCR). PCR primers were flanking the polymorphic region in intron 16 of the ACE gene.


RESULTS
The distribution of the DD, ID, and II ACE genotypes was 16%, 52%, and 32% in the control subjects and 0%, 56%, and 44% in OSAS patients, respectively. The estimated frequencies of the insertion allele and the deletion allele were 58%, 42% in the control subjects and 72%, 28% in OSAS patients, respectively. The differences were statistically significant(P < 0.05). The OSAS patients with I/I genotype had significantly longer apnea time (P < 0.05), lower minimum SaO2(P < 0.05) and more severe AHI (P < 0.05) than did the OSAS patients with I/D genotype.


CONCLUSIONS
These results indicate that the II genotype and I allele might be a risk factor for OSAS in Chinese.
Xiao
Y
Y
Sleep Disorders Center, PUMC Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730.
Huang
X
X
Qiu
C
C
D000483:Alleles; D044466:Asian People; D005260:Female; D005787:Gene Frequency; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000235:genetics; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012307:Risk Factors; D020181:Sleep Apnea, Obstructive / Q000150:complications / Q000201:enzymology / Q000235:genetics*
D007703:Peptidyl-Dipeptidase A