Solid-phase synthesis of macrolide analogues.
The synthesis of a solid-phase macrolide library is described. The library introduces three sites of diversity to a suitable macrolide scaffold via reductive aminations.
Akritopoulou-Zanze
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I
Abbott Laboratories, 100 Abbott Park Road, Abbott Park, Illinois 60064-6099, USA.
Sowin
T J
TJ
D017963:Azithromycin / Q000737:chemistry; D017291:Clarithromycin / Q000737:chemistry; D020650:Combinatorial Chemistry Techniques; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000737:chemistry; D048628:Ketolides; D018942:Macrolides / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009555:Ninhydrin
D048628:Ketolides; D018942:Macrolides; D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin; D009555:Ninhydrin; C405499:cethromycin