title: Tetrasomy 8 as a primary chromosomal abnormality in a child with acute megakaryoblastic leukemia. a case report and review of the literature.
abstract: Tetrasomy 8 is a relatively rare chromosomal abnormality in hematological disorders, and is mostly associated with myeloid malignancies and poor prognosis. In a number of cases, tetrasomy 8 has been reported as an accompanying anomaly with other chromosomal changes. In this report, we describe a 14-year-old girl with acute megakaryoblastic leukemia associated with tetrasomy 8 (primary) and trisomy 6, 19 and 20. She died 6 months after diagnosis, suggesting a relatively poor prognosis for AML with tetrasomy 8. To the best of our knowledge, this is the first report of a tetrasomy 8 abnormality associated with subtype FAB M7. Interestingly, this abnormality has not been previously reported in childhood AML patients.
authors.affiliation: Department of Genetics, Hacettepe University Ihsan Dogramaci Children's Hospital, 06100 Sihhiye, Ankara, Turkey. dilekaktas6@hotmail.com
authors.forename: D
authors.initials: D
authors.lastname: Aktas
authors.forename: E
authors.initials: E
authors.lastname: Tuncbilek
authors.forename: M
authors.initials: M
authors.lastname: Cetin
authors.forename: G
authors.initials: G
authors.lastname: Hicsonmez
mesh_terms: D000293:Adolescent; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002898:Chromosomes, Human, Pair 8; D005260:Female; D006801:Humans; D007621:Karyotyping; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*