title: Regulation of splanchnic perfusion.
abstract: In splanchnic arteries, vasodilators decrease the cytosolic free calcium concentration ([Ca(2+)]i) by inducing Ca(2+)sequestration and extrusion, by limiting the entry of extracellular Ca(2+)via L-type Ca(2+)channels and by decreasing the agonist-induced mobilization of intracellular Ca(2+). Cyclic GMP kinase and membrane hyperpolarization are important mediators of the decrease in [Ca(2+)]i. Vasoconstrictors increase [Ca(2+)]i by mobilizing intracellular Ca(2+)from the sarcoplasmic reticulum and by stimulating extracellular Ca(2+)entry via L-type Ca(2+)channels. Activation of G proteins, inositol trisphosphate, diacylglycerol and membrane depolarization are important mediators of the increase in [Ca(2+)]i.
authors.affiliation: Splanchnic Haemodynamic and Vascular Biology Laboratory, INSERM U-481, Clichy, 92118, France.
authors.forename: R
authors.initials: R
authors.lastname: Moreau
authors.forename: D
authors.initials: D
authors.lastname: Lebrec
mesh_terms: D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D011168:Portal System / Q000502:physiology*; D012680:Sensitivity and Specificity; D013152:Splanchnic Circulation / Q000502:physiology*; D014661:Vasoconstriction / Q000187:drug effects / Q000502:physiology*; D014662:Vasoconstrictor Agents / Q000008:administration & dosage; D014664:Vasodilation / Q000187:drug effects / Q000502:physiology*; D014665:Vasodilator Agents / Q000008:administration & dosage
chemical_list: D014662:Vasoconstrictor Agents; D014665:Vasodilator Agents