[Effects of NM23/NDPK in signal transduction of metastatic mouse forestomach carcinoma cells].
OBJECTIVE
To understand the role of NM23/NDPK in the transmembrane signal transduction proccess in tumor metastasis.


METHODS
The NDPK activity, IP3 contents, the invasive potentials of the cells of mouse forestomach carcinoma(MFC) substrains with different metastatic potentials and the effect of LN and EGF were observed.


RESULTS
Both the NDPK activity and the contents of IP3 of the cells of the subclone with lower metastatic potential was higher than that with higher metastatic potential. Also, the cells with lower metastatic potential had lower invasive potential and higher responsibility to the challenge of EGF compared with that higher metastatic potential. However, no different effect of LN on the cells of those subclones was found.


CONCLUSIONS
NDPK might regulate the metastasis of FMC cells by impacting the G protein efficacy with the selection of exotic signal ligands.
Hu
X
X
Institute of Basic Medical Sciences, CAMS and PUMC, Beijing 100005.
Li
Y
Y
Liu
Y
Y
Gao
J
J
Zhang
D
D
D000818:Animals; D004815:Epidermal Growth Factor / Q000494:pharmacology; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism*; D051379:Mice; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009701:Nucleoside-Diphosphate Kinase / Q000378:metabolism*; D015398:Signal Transduction; D013274:Stomach Neoplasms / Q000378:metabolism / Q000473:pathology*; D014407:Tumor Cells, Cultured
D004815:Epidermal Growth Factor; D015544:Inositol 1,4,5-Trisphosphate; D009701:Nucleoside-Diphosphate Kinase