title: The extinction program for Homo sapiens and cloning humans: trinucleotide expansion as a one-way track to extinction.
abstract: It has been uncovered that expansion of trinucleotide repeats in the human genome are causing a variety of genetic diseases. They are also identified in other loci that are not clearly related to particular diseases, which indicates such repeat expansion is one of the general forms of evolution occurring throughout the human genome. Trinucleotide repeat expansion has been shown to occur during meiosis, and is generally irreversible. In consequence, every human chromosome suffers from the burden of accumulating trinucleotide repeats along with the passage of generation, which eventually ends up in a deficiency of replication. Thus, all the human chromosomes are predicted to be 'mortal', so far as they replicate through meiosis. Naturally, the mortality of human chromosomes leads to the mortality of Homo sapiens as a species on earth. Although it is quite controversial, a radical breakthrough for humans to survive might be found through cloning reproduction without meiosis.
authors.affiliation: The Dorrance H. Hamilton Laboratories, Division of Infectious Diseases, Department of Medicine, Center for Human Virology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania, USA. kubota1@dent.okayama-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Kubota
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002877:Chromosomes, Human / Q000235:genetics / Q000502:physiology; D019976:Cloning, Organism; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*