title: Fever in subarachnoid hemorrhage: relationship to vasospasm and outcome.
abstract: OBJECTIVE
  To investigate the causes of fever in subarachnoid hemorrhage (SAH) and examine its relationship to outcome.
  
  
  BACKGROUND
  Fever adversely affects outcome in stroke. Patients with SAH are at risk for cerebral ischemia due to vasospasm (VSP). In these patients, fever may be both caused by, and potentiate, VSP-mediated brain injury.
  
  
  METHODS
  The authors prospectively studied patients admitted to a neurologic intensive care unit with nontraumatic SAH, documenting Hunt-Hess grade, Fisher group, Glasgow Coma Score, bacterial culture data, daily transcranial Doppler mean velocities, and maximum daily temperatures. Patients were classified as febrile (temperature above 38.3 degrees C for at least 2 consecutive days) or afebrile (no fever or isolated episodes of temperature above 38.3 degrees C). VSP was verified by either transcranial Doppler or angiographic criteria. Rankin scale scores on discharge were dichotomized into good (0 to 2) or poor (3 to 6) outcomes.
  
  
  RESULTS
  Ninety-two consecutive patients were studied. Thirty-eight patients were classified as febrile. No source for infection was found in 10 of 38 (26%) patients. In a multivariate analysis, three variables independently predicted fever occurrence: ventriculostomy (OR, 8.5 [CI, 2.4 to 29.7]), symptomatic VSP (OR, 5.0 [CI, 1.03 to 24.5]), and older age (OR, 1.75 per 10 years [CI, 1.02 to 3.0]). Poor outcome was related to fever (OR, 1.4 per each day febrile [CI, 1.1 to 1.88]), older age (OR, 1.64 per 10 years [CI, 1.04 to 2.58]), and intubation (OR, 21.8 [CI, 5.6 to 84.5]).
  
  
  CONCLUSIONS
  Fever in SAH is associated with vasospasm and poor outcome independently of hemorrhage severity or presence of infection.
authors.affiliation: Stroke Service of the Neurology Department, Massachusetts General Hospital, and Harvard Medical School, Boston 02114, USA.
authors.forename: J
authors.initials: J
authors.lastname: Oliveira-Filho
authors.forename: M A
authors.initials: MA
authors.lastname: Ezzeddine
authors.forename: A Z
authors.initials: AZ
authors.lastname: Segal
authors.forename: F S
authors.initials: FS
authors.lastname: Buonanno
authors.forename: Y
authors.initials: Y
authors.lastname: Chang
authors.forename: C S
authors.initials: CS
authors.lastname: Ogilvy
authors.forename: G
authors.initials: G
authors.lastname: Rordorf
authors.forename: L H
authors.initials: LH
authors.lastname: Schwamm
authors.forename: W J
authors.initials: WJ
authors.lastname: Koroshetz
authors.forename: C T
authors.initials: CT
authors.lastname: McDonald
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000503:physiopathology*; D015984:Causality; D002560:Cerebrovascular Circulation / Q000502:physiology; D005260:Female; D005334:Fever / Q000209:etiology* / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D020127:Recovery of Function / Q000502:physiology; D013345:Subarachnoid Hemorrhage / Q000150:complications / Q000503:physiopathology*; D020301:Vasospasm, Intracranial / Q000150:complications* / Q000503:physiopathology*