Sildenafil (viagra) facilitates weaning of inhaled nitric oxide following placement of a biventricular-assist device.
Sildenafil is a selective phosphodiesterase type 5 inhibitor used in the treatment of erectile dysfunction. We report the use of sildenafil to blunt the rebound pulmonary hypertension seen following withdrawal of inhaled nitric oxide (NO) and milrinone. The relatively long duration of sildenafil's action on pulmonary artery pressures and lack of systemic hemodynamic effect make it an attractive option to facilitate weaning of inhaled NO.
Mychaskiw
G
G
Department of Anesthesiology, University of Mississippi School of Medicine, Jackson, MS, USA. emychaskiw@anesthesia.umsmed.edu
Sachdev
V
V
Heath
B J
BJ
D000280:Administration, Inhalation; D000328:Adult; D006353:Heart-Assist Devices; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D009569:Nitric Oxide / Q000009:adverse effects; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D011652:Pulmonary Circulation / Q000187:drug effects; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones
D010726:Phosphodiesterase Inhibitors; D010879:Piperazines; D011687:Purines; D013450:Sulfones; D009569:Nitric Oxide; D000068677:Sildenafil Citrate