title: 6,6'-Bis(2-hydroxyphenyl)-2,2'-bipyridine manganese(III) complexes: a novel series of superoxide dismutase and catalase mimetics.
abstract: A series of novel manganese(III) complexes is described based on a 6,6'-bis(2-hydroxyphenyl)-2,2'-bipyridine template. These complexes show superoxide dismutase and catalase activity. The effect of the aromatic substitution pattern on the SAR is described.
authors.affiliation: Department of Medicinal Chemistry, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, SG1 2NY, Stevenage, UK. gmpg2704@gsk.com
authors.forename: G M
authors.initials: GM
authors.lastname: Giblin
authors.forename: P C
authors.initials: PC
authors.lastname: Box
authors.forename: I B
authors.initials: IB
authors.lastname: Campbell
authors.forename: A P
authors.initials: AP
authors.lastname: Hancock
authors.forename: S
authors.initials: S
authors.lastname: Roomans
authors.forename: G I
authors.initials: GI
authors.lastname: Mills
authors.forename: C
authors.initials: C
authors.lastname: Molloy
authors.forename: G E
authors.initials: GE
authors.lastname: Tranter
authors.forename: A L
authors.initials: AL
authors.lastname: Walker
authors.forename: S R
authors.initials: SR
authors.lastname: Doctrow
authors.forename: K
authors.initials: K
authors.lastname: Huffman
authors.forename: B
authors.initials: B
authors.lastname: Malfroy
mesh_terms: D000975:Antioxidants / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002374:Catalase / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D017895:Manganese Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D012459:Salicylates; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
chemical_list: D000975:Antioxidants; C433928:EUK-134; D017895:Manganese Compounds; D009942:Organometallic Compounds; D012459:Salicylates; D013481:Superoxides; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase