[Studies on the chemical constituents of Kaempferia marginata].
OBJECTIVE
To study the chemical constituents of the rhizomes of Kaempferia galanga L. (Zingiberaceae).


METHODS
Various chromatographic techniques were used to separate and purify. Their physico-chemical properties and spectral data were used to elucidate the structures.


RESULTS
Six compounds were isolated from the hexane extract of K. galanga. Their structures were identified as marginatol (1), 8 (14), 15-sanderacopimaradiene-1 alpha, 9 alpha-diol (2), 8 (14), 15-sanderacopimaradiene-1 alpha, 6 beta, 9 alpha-triol (3), germacrone (4), trans-ethyl p-methoxycinnamate (5) and n-pentadecane (6) on the basis of spectral data (IR, MS, 1H-1H, 13C-1H NMR, NOEs and HMBC).


CONCLUSIONS
Marginatol (1) is a new isopimarene diterpenoid and was elucidated as 8(14), 15-isopimaradiene-6 alpha-ol. Compounds 2, 3 and 4 were isolated for the first time from this plant.
Yu
J G
JG
Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences and Peking Union Medical College, Bejing 100094, China.
Yu
D L
DL
Zhang
S
S
Luo
X Z
XZ
Sun
L
L
Zheng
C C
CC
Chen
Y H
YH
D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification*; D018517:Plant Roots / Q000737:chemistry*; D030521:Zingiberaceae / Q000737:chemistry*
D004224:Diterpenes