Effect of Shiga toxin and Shiga-like toxins on eukaryotic cells.
Shigella dysenteriae and Shiga-toxin-producing Escherichia coli (STEC) elaborate the AB holotoxins, Shiga or Shiga-like toxins (Stx). Stx play a major role in the pathogenesis of haemorrhagic colitis and haemolytic uremic syndrome. This review provides an overview of the mechanisms of action of Stx and a model of the pathogenesis of Stx-induced disease.
O'Loughlin
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EV
Department of Gastroenterology, The Royal Alexandra Hospital for Children, PO Box 3515, Parramatta 2124, Westmead NSW, Australia. Tedo@chw.edu.au
Robins-Browne
R M
RM
D003092:Colitis / Q000382:microbiology; D004405:Dysentery, Bacillary / Q000382:microbiology; D004926:Escherichia coli; D006463:Hemolytic-Uremic Syndrome / Q000382:microbiology; D006801:Humans; D022622:Shiga Toxin 1 / Q000633:toxicity*; D022641:Shiga Toxin 2 / Q000633:toxicity*; D022603:Shiga Toxins / Q000494:pharmacology / Q000633:toxicity*; D012762:Shigella dysenteriae
D022622:Shiga Toxin 1; D022641:Shiga Toxin 2; D022603:Shiga Toxins