Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris.
Patients with coronary artery disease frequently have elevated antibody titers against Chlamydia pneumoniae, but whether antichlamydial antibody titers are correlated with prognosis in unstable angina remains unclear. We therefore investigated the sera of 1,096 patients with unstable angina regarding immunoglobulin (Ig) IgG, IgA, and IgM antibody titers against chlamydial lipopolysaccharides (LPS) and the concentrations of C-reactive protein (CRP) and troponin T (TnT). Anti-LPS IgG titers were increased in 45% of patients at enrollment and in 48% of patients at discharge (p <0.0001). Anti-LPS IgA titers were increased in 27% of patients at enrollment and in 33% of patients at discharge (p <0.0001). Patients who subsequently died had significantly lower IgM titers at enrollment than patients without events (p = 0.016). IgG, IgA, or IgM titers did not correlate with concentrations of CRP or TnT. In this large-scale study of patients with unstable angina, we frequently found elevated antichlamydial antibody titers. Patients with low IgM anti-LPS titers were at risk for subsequent death. However, there was no correlation between antichlamydial antibody titers and CRP or TnT.
Kähler
J
J
Department of Cardiology, University Hospital Hamburg, Germany. kaehler@uke.uni-hamburg.de
Gerth
S
S
Schäfer
P
P
Boersma
E
E
Köster
R
R
Terres
W
W
Simoons
M L
ML
Berger
J
J
Meinertz
T
T
Hamm
C W
CW
D000368:Aged; D000789:Angina, Unstable / Q000097:blood / Q000382:microbiology* / Q000401:mortality; D000907:Antibodies, Bacterial / Q000097:blood*; D002097:C-Reactive Protein / Q000032:analysis; D002689:Chlamydia / Q000276:immunology*; D016993:Chlamydophila pneumoniae / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015996:Survival Rate; D020107:Troponin T / Q000097:blood
D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008070:Lipopolysaccharides; D020107:Troponin T; D002097:C-Reactive Protein