title: Allogeneic bone marrow transplantation for infants with acute leukemia or myelodysplastic syndrome.
abstract: The objective of this study is to investigate the outcome of children 24 months of age or younger (infants) at the time of allogeneic bone marrow transplantation (BMT) for acute leukemia or myelodysplasia. We analyzed the survival rate, prognostic factors, incidences of late sequelae, and immune reconstitution in 22 infants who underwent allogeneic BMT. The 5-year event-free survival estimate was 45.5% (95% confidence interval (CI), 24.4% to 63.3%). Six patients died of transplant-related complications and six died of disease relapse. Remission status at the time of BMT was the most important prognostic factor (P = 0.005): no patient who received a transplant while their disease was not in remission survived, whereas the 5-year survival estimate for infants who underwent BMT during remission was 56% (95% CI, 31% to 75%). Long-term outcomes in the 10 infant survivors were compared with those of 10 older controls matched for diagnosis, disease status at the time of BMT, calendar year at the time of BMT, and source of stem cells. Immune function 1 year after transplantation and the incidences and spectra of late sequelae were similar for both groups during a median of 3.5 years (range, 1.5 to 7.2 years) of follow-up.
authors.affiliation: The Department of Hematology-Oncology, St Jude Children's Research Hospital, 332 N. Lauderdale Street, Memphis, TN 38105, USA.
authors.forename: W
authors.initials: W
authors.lastname: Leung
authors.forename: N
authors.initials: N
authors.lastname: Pitts
authors.forename: K
authors.initials: K
authors.lastname: Burnette
authors.forename: J M
authors.initials: JM
authors.lastname: Cunningham
authors.forename: E M
authors.initials: EM
authors.lastname: Horwitz
authors.forename: E
authors.initials: E
authors.lastname: Benaim
authors.forename: G
authors.initials: G
authors.lastname: Hale
authors.forename: P
authors.initials: P
authors.lastname: Woodard
authors.forename: C H
authors.initials: CH
authors.lastname: Pui
authors.forename: L C
authors.initials: LC
authors.lastname: Bowman
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D016026:Bone Marrow Transplantation / Q000401:mortality*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D007107:Immune System / Q000502:physiology; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000175:diagnosis / Q000401:mortality / Q000628:therapy*; D008297:Male; D016555:Matched-Pair Analysis; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000628:therapy*; D011379:Prognosis; D012074:Remission Induction; D012189:Retrospective Studies; D015996:Survival Rate; D014184:Transplantation, Homologous; D016896:Treatment Outcome