Elements involved in the regulation of the StAR gene.
The steroidogenic acute regulatory protein (StAR) mediates the transfer of cholesterol from the outer to the inner mitochondrial membrane, the regulated step in steroidogenesis. A most interesting facet of this protein is the manner in which its expression is acutely regulated. In this regard, a number of studies have concentrated on the search for consensus cis regulatory elements within its promoter, and, more importantly, on whether these elements are involved in its expression. This short review will summarize some of the findings that have been reported concerning the nature of how the expression of this gene is regulated.
Stocco
D M
DM
Department of Cell Biology and Biochemistry, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA. doug.stocco@ttmc.ttuhsc.edu
Clark
B J
BJ
Reinhart
A J
AJ
Williams
S C
SC
Dyson
M
M
Dassi
B
B
Walsh
L P
LP
Manna
P R
PR
Wang
X J
XJ
Zeleznik
A J
AJ
Orly
J
J
D000818:Animals; D004268:DNA-Binding Proteins / Q000494:pharmacology; D005786:Gene Expression Regulation; D006801:Humans; D010750:Phosphoproteins / Q000235:genetics*; D011401:Promoter Regions, Genetic / Q000187:drug effects; D000098682:Steroidogenic Acute Regulatory Protein
D004268:DNA-Binding Proteins; D010750:Phosphoproteins; D000098682:Steroidogenic Acute Regulatory Protein