title: Coumarins isolated from Angelica gigas inhibit acetylcholinesterase: structure-activity relationships.
abstract: Acetylcholinesterase (AChE) inhibitory activity-guided fractionation of Angelica gigas led to isolation and identification of a new coumarin, peucedanone (12), and isolation of 11 known coumarins. Among them, decursinol (1) represented the highest inhibitory activity toward AChE in vitro. The correlation of the inhibitory activities of the coumarins toward AChE with their chemical structures was studied.
authors.affiliation: College of Pharmacy, Seoul National University, Seoul, 151-742, Korea.
authors.forename: S Y
authors.initials: SY
authors.lastname: Kang
authors.forename: K Y
authors.initials: KY
authors.lastname: Lee
authors.forename: S H
authors.initials: SH
authors.lastname: Sung
authors.forename: M J
authors.initials: MJ
authors.lastname: Park
authors.forename: Y C
authors.initials: YC
authors.lastname: Kim
mesh_terms: D002800:Cholinesterase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology*; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D003374:Coumarins; D010936:Plant Extracts