[Post-vaccination granuloma due to aluminium hydroxide].
Post-vaccination granulomas a well-known reaction due to aluminium adsorbed vaccines. We report three cases of children who developed subcutaneous nodules at the site of a previous injection of Tetracoq*vaccine (tetanus, diphtheria, Bordetella pertussis, poliovirus). Histologically, the lesions were characterized by a necrotizing granulomatous reaction with eosinophilic crystalline material. This material stained positively with the solochrome cyanine stain and was pink-purple. This aluminium stain enabled diagnosis of post-immunization injection-site reaction due to aluminium.
Bordet
A L
AL
Service d'anatomie et de cytologie pathologiques, CHR d'Orléans, Hôpital de la Source, BP 6709, 45067 Orléans Cedex 2.
Michenet
P
P
Cohen
C
C
Arbion
F
F
Ekindi
N
N
Bonneau
C
C
Kerdraon
R
R
Coville
M
M
D000536:Aluminum Hydroxide / Q000009:adverse effects* / Q000032:analysis; D002675:Child, Preschool; D004396:Coloring Agents; D003460:Crystallization; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000009:adverse effects; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D007223:Infant; D008297:Male; D009336:Necrosis; D023321:Poliovirus Vaccines / Q000009:adverse effects; D014612:Vaccines / Q000009:adverse effects*
D004396:Coloring Agents; D015721:Diphtheria-Tetanus-Pertussis Vaccine; D023321:Poliovirus Vaccines; D014612:Vaccines; D000536:Aluminum Hydroxide