title: African origin of modern humans in East Asia: a tale of 12,000 Y chromosomes.
abstract: To test the hypotheses of modern human origin in East Asia, we sampled 12,127 male individuals from 163 populations and typed for three Y chromosome biallelic markers (YAP, M89, and M130). All the individuals carried a mutation at one of the three sites. These three mutations (YAP+, M89T, and M130T) coalesce to another mutation (M168T), which originated in Africa about 35,000 to 89,000 years ago. Therefore, the data do not support even a minimal in situ hominid contribution in the origin of anatomically modern humans in East Asia.
authors.affiliation: State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ke
authors.forename: B
authors.initials: B
authors.lastname: Su
authors.forename: X
authors.initials: X
authors.lastname: Song
authors.forename: D
authors.initials: D
authors.lastname: Lu
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Qi
authors.forename: S
authors.initials: S
authors.lastname: Marzuki
authors.forename: R
authors.initials: R
authors.lastname: Deka
authors.forename: P
authors.initials: P
authors.lastname: Underhill
authors.forename: C
authors.initials: C
authors.lastname: Xiao
authors.forename: M
authors.initials: M
authors.lastname: Shriver
authors.forename: J
authors.initials: J
authors.lastname: Lell
authors.forename: D
authors.initials: D
authors.lastname: Wallace
authors.forename: R S
authors.initials: RS
authors.lastname: Wells
authors.forename: M
authors.initials: M
authors.lastname: Seielstad
authors.forename: P
authors.initials: P
authors.lastname: Oefner
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.forename: J
authors.initials: J
authors.lastname: Jin
authors.forename: W
authors.initials: W
authors.lastname: Huang
authors.forename: R
authors.initials: R
authors.lastname: Chakraborty
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Jin
mesh_terms: D000349:Africa / Q000208:ethnology; D000483:Alleles; D001208:Asia; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006801:Humans; D008297:Male; D009154:Mutation / Q000235:genetics; D010139:Pacific Islands; D010802:Phylogeny; D011110:Polymorphism, Genetic / Q000235:genetics; D011156:Population Density; D014998:Y Chromosome / Q000235:genetics*