title: Prompt and durable hematopoietic reconstitution by unrelated cord blood transplantation in a child with Fanconi anemia.
abstract: We describe here the case of an 8-year-old girl with Fanconi anemia (FA) whose hematopoiesis was successfully restored by unrelated umbilical cord blood (UCB) transplantation. The patient became resistant to androgen therapy, and developed intracranial hemorrhage and dyserythropoiesis. Her hematopoietic recovery after the transplantation was excellent and a complete chimerism has been durably maintained. UCB should be considered as a stem cell source for transplantation when a patient with FA does not have an HLA-identical unaffected sibling donor.
authors.affiliation: Department of Pediatric Hematology/Oncology, University of Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yoshimasu
authors.forename: R
authors.initials: R
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Suenobu
authors.forename: H
authors.initials: H
authors.lastname: Yagasaki
authors.forename: H
authors.initials: H
authors.lastname: Yoshino
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Hisakawa
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: T
authors.initials: T
authors.lastname: Mitsui
authors.forename: Y
authors.initials: Y
authors.lastname: Ebihara
authors.forename: A
authors.initials: A
authors.lastname: Manabe
authors.forename: T
authors.initials: T
authors.lastname: Iseki
authors.forename: T
authors.initials: T
authors.lastname: Maekawa
authors.forename: T
authors.initials: T
authors.lastname: Nakahata
authors.forename: S
authors.initials: S
authors.lastname: Asano
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
mesh_terms: D002675:Child, Preschool; D018572:Disease-Free Survival; D005199:Fanconi Anemia / Q000150:complications / Q000628:therapy*; D005260:Female; D005312:Fetal Blood; D006085:Graft Survival; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006648:Histocompatibility; D006801:Humans; D020300:Intracranial Hemorrhages / Q000209:etiology; D018183:Transplantation Chimera