Synthesis of 1-(3-aminopropyl)-4-phenyl-1,2,4-triazolin-5-one and 1-(3-aminopropyl)-3,4-diphenyl-1,2,4-triazolin-5-one.
The reaction of 4-phenyl-1,2,4-triazolin-5-one [Ia] and 3,4-diphenyl-1,2,4-triazolin-5-one [Ib] with 1-bromo-3-chloropropane was carried out. The obtained compounds [IIa, b] were subjected to the reaction with secondary amines and ethylenediamine with resulted in 1-(3-aminopropyl)-1,2,4-triazolin-5-one derivatives.
Dobosz
M
M
Department of Organic Chemistry, Faculty of Pharmacy, Medical University, 6 Staszica Str., 20-081 Lublin, Poland.
Maliszewska-Guz
A
A
Struga
M
M
Kleinrok
Z
Z
Wielosz-Tokarzewska
E
E
Jagiełło-Wójtowicz
E
E
D000818:Animals; D005260:Female; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D014230:Triazoles; C045575:1,2,4-triazole