title: Impulsive choice induced in rats by lesions of the nucleus accumbens core.
abstract: Impulsive choice is exemplified by choosing a small or poor reward that is available immediately, in preference to a larger but delayed reward. Impulsive choice contributes to drug addiction, attention-deficit/hyperactivity disorder, mania, and personality disorders, but its neuroanatomical basis is unclear. Here, we show that selective lesions of the nucleus accumbens core induce persistent impulsive choice in rats. In contrast, damage to two of its afferents, the anterior cingulate cortex and medial prefrontal cortex, had no effect on this capacity. Thus, dysfunction of the nucleus accumbens core may be a key element in the neuropathology of impulsivity.
authors.affiliation: Department of Experimental Psychology, University of Cambridge, Downing Street, Cambridge CB2 3EB, UK. rudolf.cardinal@pobox.com
authors.forename: R N
authors.initials: RN
authors.lastname: Cardinal
authors.forename: D R
authors.initials: DR
authors.lastname: Pennicott
authors.forename: C L
authors.initials: CL
authors.lastname: Sugathapala
authors.forename: T W
authors.initials: TW
authors.lastname: Robbins
authors.forename: B J
authors.initials: BJ
authors.lastname: Everitt
mesh_terms: D000818:Animals; D001288:Attention; D001289:Attention Deficit Disorder with Hyperactivity; D001522:Behavior, Animal; D001931:Brain Mapping; D002755:Choice Behavior; D004195:Disease Models, Animal; D006179:Gyrus Cinguli / Q000502:physiology; D007175:Impulsive Behavior; D009043:Motor Activity; D009714:Nucleus Accumbens / Q000502:physiology* / Q000601:surgery; D017397:Prefrontal Cortex / Q000502:physiology; D011897:Random Allocation; D051381:Rats; D012054:Reinforcement, Psychology; D012201:Reward