title: Flumazenil's reversal of myoclonic-like movements associated with midazolam in term newborns.
abstract: Sedation is an important aspect of care for critically ill newborns. Proper sedation reduces stress during procedures such as mechanical ventilation. Midazolam, a short-acting benzodiazepine, is widely administered as a sedative in newborn intensive care units but is not without side effects. Three term newborns developed myoclonic-like abnormal movements after receiving midazolam. In one, flumazenil controlled the abnormal movements. Flumazenil is a potent benzodiazepine antagonist that competitively blocks the central effects of benzodiazepines. It can reverse the sedative effects of benzodiazepines occurring after diagnostic or therapeutic procedures or after benzodiazepine overdose. Flumazenil may be considered in cases of abnormal movements associated with midazolam. However, further studies are needed to provide guidelines for the administration of this drug in newborns.
authors.affiliation: Department of Child Health, Medical School, University of Aberdeen, Scotland.
authors.forename: W
authors.initials: W
authors.lastname: Zaw
authors.forename: D C
authors.initials: DC
authors.lastname: Knoppert
authors.forename: O
authors.initials: O
authors.lastname: da Silva
mesh_terms: D005260:Female; D005442:Flumazenil / Q000627:therapeutic use*; D018757:GABA Modulators / Q000627:therapeutic use*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007231:Infant, Newborn; D008297:Male; D008874:Midazolam / Q000009:adverse effects*; D009207:Myoclonus / Q000139:chemically induced* / Q000188:drug therapy*
chemical_list: D018757:GABA Modulators; D006993:Hypnotics and Sedatives; D005442:Flumazenil; D008874:Midazolam