title: Sputum itraconazole concentrations in cystic fibrosis patients.
abstract: Itraconazole diffusion in sputum was studied in 11 cystic fibrosis patients with allergic bronchopulmonary aspergillosis. There was a high interindividual variability in sputum itraconazole concentration and sputum/serum drug concentration ratio. Three children had sputum drug concentrations before oral administration that were lower than the itraconazole MIC at which 90% of Aspergillus fumigatus strains were inhibited, although their serum drug concentrations were within the therapeutic range.
authors.affiliation: Service de Pédiatrie Générale, Hôpital Necker-Enfants Malades, 75015 Paris, France. sermut-gaudelus@necker.fr
authors.forename: I
authors.initials: I
authors.lastname: Sermet-Gaudelus
authors.forename: A
authors.initials: A
authors.lastname: Lesne-Hulin
authors.forename: G
authors.initials: G
authors.lastname: Lenoir
authors.forename: E
authors.initials: E
authors.lastname: Singlas
authors.forename: P
authors.initials: P
authors.lastname: Berche
authors.forename: C
authors.initials: C
authors.lastname: Hennequin
mesh_terms: D000293:Adolescent; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications* / Q000378:metabolism*; D006801:Humans; D017964:Itraconazole / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D013183:Sputum / Q000737:chemistry*
chemical_list: D017964:Itraconazole