Epstein-Barr virus DNA quantitation assessed by a real-time polymerase chain reaction in a case of Burkitt's lymphoma.
A real-time PCR technique was used to quantify EBV DNA load in plasma, leukocytes, peritoneal cells, ascites and cerebrospinal fluid (CSF) at diagnosis and during the follow-up of a 21-year-old patient suffering from an abdominal form of EBV-associated Burkitt's lymphoma. The EBV DNA load correlated well with the clinical and biological remission status of the patient after chemotherapy confirming that EBV DNA quantitation in plasma and leukocytes from peripheral blood can be considered as a marker of the tumor load and can be analyzed in parallel for monitoring of EBV-related malignancies.
Solassol
J
J
Abteilung für Innere Medizin und Poliklinik m.S. Hämatologie und Onkologie, Campus Virchow-Klinikum, Medizinische Fakultät Charité der Humboldt-Universität zu Berlin, Germany.
Kreuzer
K A
KA
Lass
U
U
Schmidt
C A
CA
D000293:Adolescent; D000328:Adult; D001201:Ascites / Q000821:virology; D014408:Biomarkers, Tumor / Q000097:blood; D002051:Burkitt Lymphoma / Q000821:virology*; D016022:Case-Control Studies; D004279:DNA, Viral / Q000097:blood* / Q000134:cerebrospinal fluid; D004854:Herpesvirus 4, Human / Q000235:genetics*; D006801:Humans; D007962:Leukocytes / Q000821:virology; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D010529:Peritoneal Cavity / Q000166:cytology / Q000821:virology; D016133:Polymerase Chain Reaction / Q000379:methods
D014408:Biomarkers, Tumor; D004279:DNA, Viral