Effect of octreotide on proliferation of in vitro cultured thyroid medullary carcinoma cells.
In TT cells, originating from medullary carcinoma of the human thyroid, the presence of receptors for somatostatin was demonstrated at the ultrastructural level. Inhibitory effect of octreotide (a somatostatin analogue) was observed on proliferation of in vitro cultured TT cells and confirmed by evaluating levels of PCNA and Ki-67 proliferation-associated antigens and examining the extent of DNA damage using the comet assay. Our studies indicate a potential for application of somatostatin analogues to diagnosis and adjunct treatment in thyroid medullary carcinomas.
Zabel
M
M
Department of Histology and Embryology, University of Medical Sciences, Wrocław, Poland. mazab@am.wroc.pl
Gebarowska
E
E
Drag-Zalesińska
M
M
Wysocka
T
T
Flig
K
K
D018931:Antineoplastic Agents, Hormonal / Q000494:pharmacology*; D018276:Carcinoma, Medullary / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D004249:DNA Damage / Q000187:drug effects; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000378:metabolism; D015282:Octreotide / Q000494:pharmacology*; D013964:Thyroid Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured
D018931:Antineoplastic Agents, Hormonal; D019394:Ki-67 Antigen; D015282:Octreotide