title: [Relationship between insulin resistance and pregnancy induced hypertension].
abstract: OBJECTIVE
  To investigate whether insulin resistance is a cause of pregnancy induced hypertension (PIH).
  
  
  METHODS
  All patients who had abnormal 50 g glucose screening test accepted 75 g oral glucose tolerance test (OGTT) and insulin sensitive index (ISI) was calculated. These patients were followed up and divided into two groups (PIH group and normal pregnancy group) at third trimester of pregnancy. The difference of ISI between the PIH group and normal pregnancy group was compared.
  
  
  RESULTS
  Fast blood glucose, fast blood insulin and ISI were (4.2 +/- 0.7) mmol/L vs. (3.8 +/- 0.7) mmol/L, (107.8 +/- 48.8) pmol/L vs. (50.4 +/- 40.5) pmol/L, and -3.25 +/- 0.27 vs. -2.58 +/- 0.66 in PIH group and normal group, respectively (P < 0.05). The areas under the curve of insulin were 1,125.6 +/- 331.0 and 1,057.6 +/- 442.2 in PIH group and normal pregnancy group, respectively (P > 0.05).
  
  
  CONCLUSIONS
  Insulin resistance during second trimester of pregnancy may be one of the causes of pregnancy induced hypertension.
authors.affiliation: Department of Obstetrics and Gynecology, Shanghai First People's Hospital, Shanghai 200080, China.
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: M
authors.initials: M
authors.lastname: Qiao
authors.forename: M
authors.initials: M
authors.lastname: Jiang
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007333:Insulin Resistance; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000209:etiology*; D011254:Pregnancy in Diabetics / Q000150:complications*