title: Azithromycin inhibits quorum sensing in Pseudomonas aeruginosa.
abstract: We report that 2 microg of azithromycin/ml inhibits the quorum-sensing circuitry of Pseudomonas aeruginosa strain PAO1. Addition of synthetic autoinducers partially restored the expression of the trancriptional activator-encoding genes lasR and rhlR but not that of the autoinducer synthase-encoding gene lasI. We propose that azithromycin interferes with the synthesis of autoinducers, by an unknown mechanism, leading to a reduction of virulence factor production.
authors.affiliation: Department of Microbiology, Toho University School of Medicine, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tateda
authors.forename: R
authors.initials: R
authors.lastname: Comte
authors.forename: J C
authors.initials: JC
authors.lastname: Pechere
authors.forename: T
authors.initials: T
authors.lastname: Köhler
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: C
authors.initials: C
authors.lastname: Van Delden
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology*; D001426:Bacterial Proteins / Q000187:drug effects*; D004268:DNA-Binding Proteins / Q000187:drug effects; D007763:Lac Operon / Q000187:drug effects; D026901:Membrane Transport Proteins; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D015534:Trans-Activators / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; C080365:LasR protein, Pseudomonas aeruginosa; D026901:Membrane Transport Proteins; C408983:QsrP protein, Vibrio fischeri; D015534:Trans-Activators; C082573:xcpR protein, Pseudomonas aeruginosa; D017963:Azithromycin