title: The identification and characterization of hydrazinyl urea-based antibacterial agents through combinatorial chemistry.
abstract: An effort to identify novel inhibitors of peptidoglycan synthesis with antibacterial activity resulted in the discovery of a series of biaryl urea-based antibacterial agents through isolation of a by-product from a mixture-based combinatorial library of semi-carbazones and subsequent parallel synthesis efforts. The compounds were shown to possess broad spectrum antibacterial activity against gram-positive drug resistant pathogens, and showed apparent specificity for disruption of the bacterial cell wall biosynthesis pathway.
authors.affiliation: Procter & Gamble Pharmaceuticals, Healthcare Research Center, Mason, OH 45040, USA. lwilson3@prius.jnj.com
authors.forename: L J
authors.initials: LJ
authors.lastname: Wilson
authors.forename: T W
authors.initials: TW
authors.lastname: Morris
authors.forename: Q
authors.initials: Q
authors.lastname: Wu
authors.forename: P J
authors.initials: PJ
authors.lastname: Renick
authors.forename: C N
authors.initials: CN
authors.lastname: Parker
authors.forename: M C
authors.initials: MC
authors.lastname: Davis
authors.forename: H D
authors.initials: HD
authors.lastname: McKeever
authors.forename: P M
authors.initials: PM
authors.lastname: Hershberger
authors.forename: A G
authors.initials: AG
authors.lastname: Switzer
authors.forename: G
authors.initials: G
authors.lastname: Shrum
authors.forename: S
authors.initials: S
authors.lastname: Sunder
authors.forename: D R
authors.initials: DR
authors.lastname: Jones
authors.forename: S S
authors.initials: SS
authors.lastname: Soper
authors.forename: R L
authors.initials: RL
authors.lastname: Dobson
authors.forename: T
authors.initials: T
authors.lastname: Burt
authors.forename: K L
authors.initials: KL
authors.lastname: Morand
authors.forename: M
authors.initials: M
authors.lastname: Stella
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D002473:Cell Wall / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques; D006834:Hydrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D014508:Urea / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D006834:Hydrazines; C029424:hydrazine; D014508:Urea