title: Which duration of postsaccadic slowing identifies anticipatory saccades during smooth pursuit eye movements?
abstract: Increased frequency of anticipatory saccades during smooth pursuit eye movements is a potential marker of genetic risk for schizophrenia. Postsaccadic slowing criteria are used to separate anticipatory from other types of saccades. However, the necessary duration of slowed pursuit required to identify an anticipatory saccade remains undetermined. We explored the effect of various postsaccadic slowing duration criteria on effect size in a comparison of younger and older schizophrenic and normal adults. For large anticipatory saccades, varying the duration of postsaccadic slowing criteria did not notably change effect size. For smaller leading saccades, a limited 50-ms duration postsaccadic slowing criterion produced the largest effect size (1.54), and maintained a similar effect size across a broad age range. Leading saccades with a limited duration postsaccadic slowing criteria are a possible marker of genetic risk for schizophrenia.
authors.affiliation: Department of Psychiatry, University of Colorado Health Sciences Center, Denver, USA. randy.ross@uchsc.edu
authors.forename: R G
authors.initials: RG
authors.lastname: Ross
authors.forename: A
authors.initials: A
authors.lastname: Olincy
authors.forename: G
authors.initials: G
authors.lastname: Zerbe
authors.forename: A
authors.initials: A
authors.lastname: Radant
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011698:Pursuit, Smooth / Q000502:physiology*; D012438:Saccades / Q000502:physiology*; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology