Oxygen-sensitive cation transport in sickle cells.
There are many examples of O2-sensitive solute transport in vertebrate red cells. The response is selective, specific, and conserved across the entire vertebrate spectrum. A number of possible physiological roles have been proposed, but abnormal responses to O2 may also be important pathologically. Significant alterations in O2 dependence of red cell cation transport are observed in sickle cell disease (and also following exposure to oxidants) and probably contribute to its pathophysiology. In this paper, we review some of the features of O2-sensitive solute transporters in red cells and possible reasons for the abnormal response in sickle cells. Our aim is to identify specific, novel pharmacological inhibitors of these abnormal pathways and thereby ameliorate the disease.
Gibson
J S
JS
Department of Physiology, University of London, London, Tooting, SW17 0RE, United Kingdom. jsgibson@sghms.ac.uk
D000755:Anemia, Sickle Cell / Q000378:metabolism / Q000473:pathology*; D000818:Animals; D002412:Cations / Q000378:metabolism; D006801:Humans; D017136:Ion Transport / Q000187:drug effects; D016877:Oxidants / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology*
D002412:Cations; D016877:Oxidants; D010100:Oxygen