title: Sign of Leser-Trélat associated with adenocarcinoma of the rectum.
abstract: The acute onset and/or rapid increase in size and number of multiple seborrheic keratoses associated with internal malignancy is called sign of Leser-Trélat. Although some authors reject its existence, there are more than 80 well-documented case reports in the literature. Here, we report a 75-year-old man who presented with abrupt appearance of multiple seborrheic keratoses without any suspicious symptom of cancer. The screening for malignant neoplasms let us detect a rectal adenocarcinoma that was in a curative stage. This case-report illustrates a true sign of Leser-Trélat, and proves that these patients must be appropriately investigated for underlying malignancy.
authors.affiliation: Department of Dermatology, Complejo Hospitalario Universitario, Faculty of Medicine, Santiago de Compostela, Spain. mejaime@usc.es
authors.forename: M
authors.initials: M
authors.lastname: Ginarte
authors.forename: D
authors.initials: D
authors.lastname: Sánchez-Aguilar
authors.forename: J
authors.initials: J
authors.lastname: Toribio
mesh_terms: D000230:Adenocarcinoma / Q000145:classification / Q000150:complications* / Q000175:diagnosis; D000368:Aged; D001466:Barium Sulfate; D003287:Contrast Media; D004733:Enema; D006801:Humans; D017492:Keratosis, Seborrheic / Q000209:etiology* / Q000473:pathology; D008297:Male; D008403:Mass Screening; D009367:Neoplasm Staging; D012004:Rectal Neoplasms / Q000145:classification / Q000150:complications* / Q000175:diagnosis
chemical_list: D003287:Contrast Media; D001466:Barium Sulfate