Sputum itraconazole concentrations in cystic fibrosis patients.
Itraconazole diffusion in sputum was studied in 11 cystic fibrosis patients with allergic bronchopulmonary aspergillosis. There was a high interindividual variability in sputum itraconazole concentration and sputum/serum drug concentration ratio. Three children had sputum drug concentrations before oral administration that were lower than the itraconazole MIC at which 90% of Aspergillus fumigatus strains were inhibited, although their serum drug concentrations were within the therapeutic range.
Sermet-Gaudelus
I
I
Service de Pédiatrie Générale, Hôpital Necker-Enfants Malades, 75015 Paris, France. sermut-gaudelus@necker.fr
Lesne-Hulin
A
A
Lenoir
G
G
Singlas
E
E
Berche
P
P
Hennequin
C
C
D000293:Adolescent; D001229:Aspergillosis, Allergic Bronchopulmonary / Q000150:complications / Q000188:drug therapy*; D001232:Aspergillus fumigatus / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications* / Q000378:metabolism*; D006801:Humans; D017964:Itraconazole / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D013183:Sputum / Q000737:chemistry*
D017964:Itraconazole