title: [P53 tumor suppressor gene in digestive neoplasms].
abstract: Malignant diseases of the digestive tract cause more than 50% of deaths due to cancer in Chile. There is a high incidence of gastric and gallbladder cancer and an increasing frequency of colorectal cancer. P53 tumor suppressor gene has a great importance in carcinogenesis and its alterations are specially important in digestive tract tumors such as colorectal cancer. There is contradictory evidence about the frequency of p53 gene or protein alterations or their biological significance. There is little information about p53 in Chile and it is mostly limited to immunohistochemical studies. This revision analyzes the frequency of p53 alterations in digestive tract tumors in Chile, using immunohistochemical and molecular biology methods. A special emphasis is given to the prognostic importance of this gene.
authors.affiliation: Unidad de Anatomía Patológica, Servicio y Departamento de Cirugía, Hospital Temuco, Facultad de Medicina, Universidad de la Frontera.
authors.forename: J C
authors.initials: JC
authors.lastname: Roa
authors.forename: I
authors.initials: I
authors.lastname: Roa
authors.forename: J C
authors.initials: JC
authors.lastname: Araya
authors.forename: M A
authors.initials: MA
authors.lastname: Villaseca
authors.forename: A
authors.initials: A
authors.lastname: Melo
authors.forename: L
authors.initials: L
authors.lastname: Burgos
mesh_terms: D004067:Digestive System Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D005819:Genetic Markers; D006801:Humans; D011379:Prognosis
chemical_list: D005819:Genetic Markers