Hereditary predisposition to low interleukin-10 production in children with extended oligoarticular juvenile idiopathic arthritis.
OBJECTIVE
To determine whether children with extended oligoarticular juvenile idiopathic arthritis (JIA) produce less of the anti-inflammatory cytokine interleukin-10 (IL-10) than those with persistent oligoarticular JIA.


METHODS
We measured IL-10 production in the parents of children with oligoarticular or extended oligoarticular JIA, from whole-blood cultures stimulated with lipopolysaccharide.


RESULTS
IL-10 production was lower in the parents of children with extended oligoarticular JIA compared with those of children with oligoarticular JIA (P=0.034). There was an increase in the percentage of ATA-containing genotypes (i.e. genotypes ATA/ATA, ATA/ACC or ATA/GCC) in the parents of children with extended oligoarticular JIA compared with healthy controls (P<0.02) but not in the parents of children with oligoarticular JIA.


CONCLUSIONS
As approximately 84% of the variation in IL-10 production is thought to be genetically regulated, these results suggest that stimulated IL-10 production would be lower in children with extended oligoarticular JIA. Because IL-10 is an anti-inflammatory cytokine, this may partly explain why this group of children has more severe disease.
Crawley
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Department of Molecular Pathology, University College London Medical School, 46 Cleveland Street, London W1T 4JF, UK.
Kon
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Woo
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D000293:Adolescent; D001171:Arthritis, Juvenile / Q000097:blood* / Q000235:genetics*; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005220:Fathers; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006239:Haplotypes; D006801:Humans; D016753:Interleukin-10 / Q000096:biosynthesis*; D008297:Male; D009035:Mothers; D016133:Polymerase Chain Reaction
D016753:Interleukin-10