The metabolic pathways of high-density lipoprotein, low-density lipoprotein, and triglycerides: a current review.
Three major interconnected pathways are involved in lipoprotein metabolism: (1) the transport of dietary or exogenous fat; (2) the transport of hepatic or endogenous fat; and (3) reverse cholesterol transport. These pathways are interdependent and disruptions in one will affect the function and products of the others. For example, a mutation such as one in the ABC1 protein can disrupt normal transport and processing of cholesterol. High-density lipoprotein cholesterol (HDL-C) appears to have cardioprotective properties because of its involvement in certain processes such as reverse cholesterol transport and inhibition of low-density lipoprotein cholesterol (LDL-C) oxidation. Certain agents, such as niacin, which increases HDL-C, lowers lipoprotein (a), and targets specific enzymes or receptors, may be highly beneficial for patients at risk of cardiovascular disease.
Kwiterovich
P O
PO
Johns Hopkins Lipid Research Atherosclerosis Division, Johns Hopkins Medical Institutions, Baltimore, Maryland 21205, USA.
D002784:Cholesterol / Q000378:metabolism*; D008078:Cholesterol, LDL / Q000378:metabolism*; D003327:Coronary Disease / Q000517:prevention & control; D006801:Humans; D008099:Liver / Q000378:metabolism*; D014280:Triglycerides / Q000378:metabolism*
D008078:Cholesterol, LDL; D014280:Triglycerides; D002784:Cholesterol