title: [The experimental study on material basis of motor skill plasticity after acute cerebral infarction].
abstract: OBJECTIVE
  To investigate the structure basis of motor skill plasticity and the recovery mechanism after acute cerebral infarction.
  
  
  METHODS
  After MCAO, the motor skill of rats was examined via beam walking test; and the neuron, synapse and the distribution of neurofilament (NF), microtubule associated protein 2 (MAP2), growth associated protein 43 (GAP43) and synaptophysin (SYP) were observed by electron scope and immunohistology staining.
  
  
  RESULTS
  All rats had paralysis after MCAO. The motor skill began to recover significantly at the end of 3 weeks, and kept to improve. The number of injured neuron decreased to normal level at week 9 after an increase resulted from MCAO(1st week: 74.6 +/- 8.8/200 field, 9th week: 2.6 +/- 2.5/200 field); the number and structure of synapse regained to normal level gradually, at last outstripped the control group (number of synapse, 1st week: 8.8 +/- 1.7/8,000 field, 9th week: 15.3 +/- 2.4/8,000 field; normal control: 12.3 +/- 2.0/8,000 field); So did SYP, NF and MAP2. The GAP43 increased only at week 1.
  
  
  CONCLUSIONS
  With the reduction of apoptosis cell, the relevant changes in the number, function and structure of synapse form the material basis of motor skill's plasticity together after cerebral infarction. The regeneration of neuron dose not play important role in motor skill recovery.
authors.affiliation: Neurology Department of the First Affiliated Hospital, Sun Yet-san University of Medical Sciences, Guangzhou 510080, China.
authors.forename: R
authors.initials: R
authors.lastname: Huang
authors.forename: Y
authors.initials: Y
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Fang
mesh_terms: D000208:Acute Disease; D000818:Animals; D002544:Cerebral Infarction / Q000473:pathology / Q000503:physiopathology*; D020244:Infarction, Middle Cerebral Artery / Q000473:pathology / Q000503:physiopathology; D008297:Male; D009048:Motor Skills / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley