Siglecs, sialic acids and innate immunity.
Siglecs are members of the Ig superfamily that bind to sialic acid (Sia) and are mainly expressed by cells of the hematopoietic system. Until three years ago, only four Siglecs were known, namely sialoadhesin, CD22, myelin-associated glycoprotein and CD33. Since then, a further six human CD33-related Siglecs with features of inhibitory receptors have been identified and shown to be expressed by discrete subsets of leukocytes. Recognition of Sia by these Siglecs could play a role in the regulation of the innate immune system.
Crocker
P R
PR
The Wellcome Trust Biocentre, School of Life Sciences, University of Dundee, DD1 5EH, Dundee, UK. p.r.crocker@dundee.ac.uk
Varki
A
A
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000502:physiology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000502:physiology*; D015214:Antigens, Differentiation, Myelomonocytic / Q000502:physiology*; D015815:Cell Adhesion Molecules; D006801:Humans; D007107:Immune System / Q000502:physiology*; D037102:Lectins; D008562:Membrane Glycoproteins / Q000502:physiology*; D018448:Models, Immunological; D008969:Molecular Sequence Data; D018992:Myelin-Associated Glycoprotein / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology*; D063267:Sialic Acid Binding Ig-like Lectin 1; D051918:Sialic Acid Binding Ig-like Lectin 2; D063268:Sialic Acid Binding Ig-like Lectin 3; D012794:Sialic Acids / Q000502:physiology*
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D015214:Antigens, Differentiation, Myelomonocytic; C497867:CD22 protein, human; C571163:CD33 protein, human; D015815:Cell Adhesion Molecules; D037102:Lectins; D008562:Membrane Glycoproteins; D018992:Myelin-Associated Glycoprotein; D011971:Receptors, Immunologic; C571166:SIGLEC1 protein, human; D063267:Sialic Acid Binding Ig-like Lectin 1; D051918:Sialic Acid Binding Ig-like Lectin 2; D063268:Sialic Acid Binding Ig-like Lectin 3; D012794:Sialic Acids