Preliminary immunohistochemical study of C cells of the thyroid and endocrine cells of the parathyroid glands in rats after prolonged exposure to cadmium.
The effect of cadmium (Cd) on the thyroid and parathyroid glands was examined following a 12-week exposure of rats to 5 or 50 mg Cd/dm3. Immunohistochemical methods were used to determine calcitonin (CT), calcitonin-gene related peptide (GGRP), parathormone (PTH), somatostatin (ST), synaptophysin (SPh) and neuron-specific enolase (NSE). Calcium and cadmium concentrations in the femoral bone were assayed. The animals exposed to cadmium showed attenuation of all reactions, which was most distinct after 50 mg Cd/dm3. Exposure-dependent cadmium accumulation and a decrease in calcium concentration in the femoral bone were noted.
Piłat-Marcinkiewicz
B
B
Department of Histology and Embryology, Medical Academy, Białystok, Poland.
Sawicki
B
B
Brzóska
M
M
Zabel
M
M
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology; D002104:Cadmium / Q000378:metabolism; D002105:Cadmium Poisoning / Q000378:metabolism / Q000473:pathology*; D002118:Calcium / Q000378:metabolism; D004702:Endocrine Glands / Q000378:metabolism / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D010280:Parathyroid Glands / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000473:pathology*
D002104:Cadmium; D002118:Calcium