Syntheses of certain 3-aryl-2-propenoates and evaluation of their cytotoxicity.
A series of 3-aryl-2-propenoates including cinnamates, (E)-methyl/ethyl 3-[2-(1,4-dimethoxy-5,8-dione)naphthalenyl]-2-propenoates (8ba, 8bb) and (E)-methyl/ethyl 3-[2-(1,4-dihydroxy-9,10-dione)anthracenyl]-2-propenoates (9aa,9ab) was synthesized and evaluated for antitumor cytotoxicity. It was found that the ortho- or para-dihydroxy funtionality on the aryl ring was essential for the cytotoxicity of cinnamates. Compounds 8ba, 8bb and 9aa, 9ab showed potent cytotoxicity against various tumor cell lines.
Nam
N H
NH
College of Pharmacy, Chungnam National University, Taejon, South Korea.
You
Y J
YJ
Kim
Y
Y
Hong
D H
DH
Kim
H M
HM
Ahn
B Z
BZ
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002109:Caffeic Acids / Q000737:chemistry; D002470:Cell Survival / Q000187:drug effects; D002934:Cinnamates / Q000737:chemistry; D006801:Humans; D011407:Propane / Q000031:analogs & derivatives* / Q000737:chemistry* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D002109:Caffeic Acids; D002934:Cinnamates; D011407:Propane