[A new signal receptor family--a review of the current progress of Toll/IL-1R family].
Toll receptor was first identified in studies of dorsalventral polarity formation of drosophila embryo. As its similarity in structure, function and signal transduction pathway to the IL-1 receptor, Toll becomes a member of a new signal receptor family--the Toll/IL-1R family. Besides participating in embryonic development, this signal receptor family also plays a key role in triggering innate defenses against pathogens, in which the function of human Toll protein in the pathogenesis of LPS is especially interested.
Chen
J
J
Institute of Burn Research, Southwest Hospital, Third Military Medical College, Chongqing 400038.
Luo
X D
XD
Yang
Z C
ZC
Chang
Z L
ZL
D000595:Amino Acid Sequence; D000818:Animals; D004330:Drosophila; D029721:Drosophila Proteins; D005314:Embryonic and Fetal Development / Q000502:physiology; D004731:Endotoxins / Q000633:toxicity; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000502:physiology*; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000502:physiology*; D017472:Receptors, Interleukin-1 / Q000737:chemistry / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D004731:Endotoxins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D017472:Receptors, Interleukin-1; D051198:Toll-Like Receptor 5; D051193:Toll-Like Receptors; C495341:tehao protein, Drosophila