Expression of laminin-5-gamma-2 chain in intraductal papillary-mucinous and invasive ductal tumors of the pancreas.
The laminin-5-gamma-2 chain is expressed in various invasive carcinoma cells. To clarify the relationship between laminin-5 expression and the development of intraductal papillary-mucinous tumors (IPMTs), we performed an immunohistochemical study of 26 IPMTs and 30 invasive ductal adenocarcinomas. Cases were classified into five groups: intraductal papillary-mucinous adenoma (Group A; n = 8), adenocarcinoma without invasion (Group B; n = 3), adenocarcinoma with minimal invasion (Group C; n = 5), adenocarcinoma with macroscopically evident invasion (Group D; n = 10), and invasive ductal adenocarcinoma (conventional type; Group E; n = 30). In the invasive components of Groups D and E, laminin-5 was expressed in 80% and 100% of cases, respectively. In the intraductal components of IPMTs, expression of laminin-5 was not seen in Groups A and B, whereas they were seen in one case in Group C (20%) and in seven in Group D (70%). Most of the staining patterns of the intraductal components were focal and scattered. Laminin-5-gamma-2 expression in the intraductal components of IPMTs tends to increase as tumors develop and may be a indicator of the potential invasiveness of the tumor cells.
Fukushima
N
N
Clinical Laboratory, National Cancer Center Hospital, Tokyo, Japan.
Sakamoto
M
M
Hirohashi
S
S
D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000378:metabolism* / Q000556:secondary; D021441:Carcinoma, Pancreatic Ductal / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000378:metabolism* / Q000556:secondary; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000378:metabolism*; D018291:Cystadenoma, Mucinous / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D018292:Cystadenoma, Papillary / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000378:metabolism* / Q000473:pathology; D000097794:Kalinin
D015815:Cell Adhesion Molecules; D000097794:Kalinin