title: Platinum carboxylato-pendant-arm macrocycles: structure, redox properties and anti-cancer potential.
abstract: In an attempt to generate new platinum compounds that may be effective in the treatment of cancer, as well as having a lower toxicity than traditional platins and being orally viable, we are studing the synthesis and reactivity of platinum complexes of tetraazamacrocycles bearing carboxylato pendant arms. We have synthesized adducts of meso- and rac-5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-1,7-diacetic acid (L(1)H(2)). The meso-Pt(II)L(1) complex is unstable with respect to disproportionation, forming platinum metal and [meso-Pt(IV)L(1)](2+). The rac-isomer shows less tendency to disproportionate. Cyclic voltammetry suggests that the rac-Pt(II)L(1) complex undergoes two one-electron oxidations. Using bis-triazacyclononanenickel(III), [Ni(III)(tacn)(2)](3+) as an outer-sphere oxidant, the self-exchange rate for the [Pt(II/III)L](0/+) couple has been estimated at 0.034 M(-1) s(-1).
authors.affiliation: Department of Chemistry, University of Prince Edward Island, 550 University Avenue, Charlottetown, PE, C1A 4P3, Canada. rhaines@upei.ca
authors.forename: R I
authors.initials: RI
authors.lastname: Haines
authors.forename: D R
authors.initials: DR
authors.lastname: Hutchings
authors.forename: T M
authors.initials: TM
authors.lastname: McCormack
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry*; D010084:Oxidation-Reduction; D017671:Platinum Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D017671:Platinum Compounds