title: [High-affinity glutamate transporters].
abstract: High-affinity glutamate transporters are located predominantly in the plasma membrane of neurons and glial cells. They have the capacity to take up glutamate from the extracellular space into the cells against its concentration gradient to terminate glutamatergic transmission and to keep the extracellular glutamate concentration at low levels to protect neurons from glutamate toxicity. As glutamate transporters were recently cloned, the research in this field has been greatly advancing. This article focuses on recent progress in the study of molecular structure, distribution of expression, physiological significance, structure-function relationships of these transporters.
authors.affiliation: Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai 200031.
authors.forename: R
authors.initials: R
authors.lastname: Yang
authors.forename: X L
authors.initials: XL
authors.lastname: Yang
mesh_terms: D027322:Amino Acid Transport System X-AG / Q000096:biosynthesis / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D000818:Animals; D003001:Cloning, Molecular; D018698:Glutamic Acid / Q000378:metabolism; D015394:Molecular Structure; D051381:Rats; D014981:Xenopus
chemical_list: D027322:Amino Acid Transport System X-AG; D018698:Glutamic Acid