The follicular versus marginal zone B lymphocyte cell fate decision is regulated by Aiolos, Btk, and CD21.
Most splenic B cells in mice that lack Aiolos are mature IgD(hi)IgM(lo) follicular lymphocytes, suggesting that maturation signals delivered via the BCR are enhanced in the absence of Aiolos. The enhanced maturation of follicular B cells is accompanied by the absence of MZ B lymphocytes and the downregulation of CD21 expression in follicular B cells, all of which depend on the generation of signals via Btk, which is in epistasis to Aiolos. The inverse relationship between the strength of BCR signaling and MZ B cell development is supported by an examination of MZ B cells in CD21 null mice. These data support the view that antigens (in contrast to "tonic" signals) drive the development of naive B cells.
Cariappa
A
A
Cancer Center and, Massachusetts General Hospital and, Harvard Medical School, Boston, MA 02129, USA.
Tang
M
M
Parng
C
C
Nebelitskiy
E
E
Carroll
M
M
Georgopoulos
K
K
Pillai
S
S
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation; D002458:Cell Fractionation; D004843:Epistasis, Genetic; D006412:Hematopoietic Stem Cells / Q000166:cytology; D051740:Ikaros Transcription Factor; D018655:Lymphocyte Count; D051379:Mice; D018345:Mice, Knockout; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000502:physiology*; D011947:Receptors, Antigen, B-Cell / Q000502:physiology; D017464:Receptors, Complement 3d / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013154:Spleen / Q000166:cytology*; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*
C491396:Ikzf3 protein, mouse; D011947:Receptors, Antigen, B-Cell; D017464:Receptors, Complement 3d; D015534:Trans-Activators; D051740:Ikaros Transcription Factor; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase