title: Method development for the high-performance liquid chromatographic enantioseparation of 2-cyanocycloalkanols.
abstract: An indirect high-performance liquid chromatographic method is developed for the enantioseparation of cis- and trans-2-cyanocyclopentanol and -cyclohexanol. The racemic cis-(1S,2S and 1R,2R)- or trans-(1S,2R and 1R,2S)-2-cyanocycloalkanols are converted to their diastereomers formed with (S)-(+)- or (R)-(-)-alpha-methoxy-alpha-(trifluoromethyl)phenylacetyl chloride. The diastereomers are separated on a reversed-phase column, and the conditions of derivatization and HPLC analysis are optimized.
authors.affiliation: Department of Inorganic and Analytical Chemistry, University of Szeged, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Török
authors.forename: A
authors.initials: A
authors.lastname: Péter
authors.forename: E
authors.initials: E
authors.lastname: Forró
authors.forename: F
authors.initials: F
authors.lastname: Fülöp