Tea flavonoids and cardiovascular health.
Tea is rich in antioxidant polyphenols (catechins, flavonols, theaflavins and thearubigins). Epidemiological evidence relating regular consumption of tea or related polyphenols to CHD is equivocal. Catechins are absorbed from tea, but low plasma concentrations are attained. The bioavailability of theaflavins and thearubigins is unknown. Tea does not reduce blood pressure or plasma lipids in well-controlled human trials. Tea polyphenols inhibit LDL lipid peroxidation in vitro, but the effect ex vivo is small. The plasma antioxidant potential increases after drinking green but not black tea. Tea consumption tended to reduce the development of aortic atherosclerosis in rabbits. Tea polyphenols exert marked effects on cells, and inhibit neutrophil migration and inflammatory responses, sometimes at low concentrations. These diverging results suggest potential beneficial effects, but emphasize the need for good human trials of tea using early markers of CHD before firm conclusions can be drawn.
Riemersma
R A
RA
Cardiovascular Research Unit, University of Edinburgh, UK. rudolph.riemersma@ed.ac.uk
Rice-Evans
C A
CA
Tyrrell
R M
RM
Clifford
M N
MN
Lean
M E
ME
D000818:Animals; D001682:Biological Availability; D002318:Cardiovascular Diseases / Q000517:prevention & control*; D002465:Cell Movement / Q000187:drug effects; D018849:Controlled Clinical Trials as Topic; D005260:Female; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D013662:Tea / Q000737:chemistry*
D005419:Flavonoids; D013662:Tea