Acute thrombosis of the renal transplant artery after a single dose of OKT3.
We present the case of an 18-year-old male who 8 months after a living-related donor, one-haplotype-matched renal transplantation developed acute thrombosis of the renal allograft artery, within 10 h of the first dose of OKT3. The antibody therapy had followed five daily doses of intravenous pulse methylprednisolone for a Banff class 1B acute tubulointerstitial rejection, on a ciclosporin-based immunosuppression protocol. We briefly review the literature on the incidence of vascular thrombosis after transplantation and the procoagulant effects of OKT3, pulse methylprednisolone, and ciclosporin therapy.
Shankar
R
R
Division of Nephrology, Manipal Hospital, Bangalore, India.
Bastani
B
B
Salinas-Madrigal
L
L
Sudarshan
B
B
D000293:Adolescent; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000009:adverse effects*; D016030:Kidney Transplantation; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects; D016853:Muromonab-CD3 / Q000008:administration & dosage / Q000009:adverse effects*; D011183:Postoperative Complications; D012078:Renal Artery Obstruction / Q000209:etiology*; D013927:Thrombosis / Q000209:etiology*
D007166:Immunosuppressive Agents; D016853:Muromonab-CD3; D016572:Cyclosporine; D008775:Methylprednisolone