[Expression of beta 2-adrenoceptor on peripheral lymphocyte and the level of plasma cAMP in patients with pregnancy induced hypertension].
OBJECTIVE
To evaluate the alteration of beta 2-adrenoceptor-cAMP system in patients with pregnancy-induced hypertension (PIH).


METHODS
The Bmax of beta 2-adrenoceptor on the lymphocyte was examined by radioligand binding technique. The level of plasma cAMP was observed by radio competitive protein binding assay.


RESULTS
The Bmax of beta 2-adrenoceptor (259 fmol/10(6) cell +/- 22 fmol/10(6) cell) on the lymphocytes was significantly higher in PIH group than in control group (247 fmol/10(6) cell +/- 23 fmol/10(6) cell). There was no significant difference between the PIH group and the controls. The content of plasma cAMP (2.94 nmol/40 microliters +/- 0.91 nmol/40 microliters) was significantly higher in PIH group than in control group (0.19 nmol/40 microliters +/- 0.05 nmol/40 microliters).


CONCLUSIONS
The mechanism of PIH may be related with the activity of beta 2-adrenoceptor-cAMP system.
Zhang
L
L
Department of Obstetrics and Gynecology, Second Teaching Hospital, Bethune University of Medical Sciences, Changchun 130041, China.
Chen
M
M
Zhang
W
W
D000328:Adult; D000242:Cyclic AMP / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000097:blood*
D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP