[Effect of 764-3 on ventricular collagen deposition in pulmonary hypertension induced by chronic hypoxia and monocrotaline in rats].
OBJECTIVE
To observe the effect of 764-3 on ventricular collagen deposition in pulmonary hypertension induced by chronic hypoxia or monocrotaline (MCT) in rats.


METHODS
Wistar rats were divided into 10 groups. The hypobaric hypoxia group received 764-3 20 mg/kg once daily subcutaneously and the MCT group treated with 764-3 40 mg/kg once daily. The hemodynamic and biochemical parameters were measured.


RESULTS
At the time of 2 weeks and 4 weeks after treated with hypoxia or MCT, the pulmonary arterial pressure (PAP) of rats raised significantly and the right ventricular collagen content (RVCC) increased markedly. 764-3 could reduce the raised PAP induced either by hypoxia or MCT. It could lower the elevated RVCC of hypobaric hypoxia group at 2 weeks from 76.3 +/- 13.3 to 59.4 +/- 11.4 (P < 0.01), and the RVCC of MCT group lowered from 293.4 +/- 73.9 to 210.1 +/- 37.6(P < 0.01).


CONCLUSIONS
764-3 could partially prevent right ventricular collagen deposition induced by hypoxia and has therapeutic effect on that induced by MCT.
Liu
Z
Z
Cardiovascular Institute and Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037.
Cheng
X
X
Cai
R
R
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D003094:Collagen / Q000037:antagonists & inhibitors / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006976:Hypertension, Pulmonary / Q000150:complications / Q000188:drug therapy*; D017380:Hypertrophy, Right Ventricular / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D008297:Male; D010936:Plant Extracts; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D027561:Salvia miltiorrhiza
D002121:Calcium Channel Blockers; D004365:Drugs, Chinese Herbal; C079053:IH 764-3; D010936:Plant Extracts; D003094:Collagen