title: Mechanisms of epileptogenesis.
abstract: The cellular mechanisms of epileptogenesis are reviewed as related to their role(s) in the expression of hyperexcitability and hypersynchrony. The data on the roles of the glutamate, GABA, acetylcholine, and adenosine receptors is discussed. The recent information on the role of glial cells in the expression of epileptogenicity is reviewed.
authors.affiliation: Department of Neurology, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA. najmi@ccf.org
authors.forename: I
authors.initials: I
authors.lastname: Najm
authors.forename: Z
authors.initials: Z
authors.lastname: Ying
authors.forename: D
authors.initials: D
authors.lastname: Janigro
mesh_terms: D001921:Brain / Q000378:metabolism / Q000503:physiopathology*; D002450:Cell Communication / Q000502:physiology; D004569:Electroencephalography; D004827:Epilepsy / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology*; D006801:Humans; D009457:Neuroglia / Q000378:metabolism; D018091:Receptors, AMPA / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000378:metabolism; D017470:Receptors, Glutamate / Q000378:metabolism; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018091:Receptors, AMPA; D011950:Receptors, Cholinergic; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D005680:gamma-Aminobutyric Acid