Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2.
Highly potent CCR3 antagonists have been developed from a previously reported series of phenylalanine ester-based leads. Solution-phase, parallel synthesis optimization was utilized to identify highly potent, functional CCR3 antagonists.
Dhanak
D
D
SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426-0989, USA. dhanak-1@sbphrd.com
Christmann
L T
LT
Darcy
M G
MG
Keenan
R M
RM
Knight
S D
SD
Lee
J
J
Ridgers
L H
LH
Sarau
H M
HM
Shah
D H
DH
White
J R
JR
Zhang
L
L
D006801:Humans; D010649:Phenylalanine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
C515350:CCR3 protein, human; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; D010649:Phenylalanine