Salmonella excretion after cessation of tosufloxacin therapy in acute nontyphoid salmonella enterocolitis.
Symptomatic nontyphoid salmonella enterocolitis patients were treated with tosufloxacin (TFLX) at oral doses of 150 mg three times a day for 5 to 7 days, but bacterial relapse without symptoms occurred in 85% of the patients within 15 days after the cessation of therapy. Our study indicates that TFLX may not be an ideal drug against symptomatic salmonella enterocolitis from a bacteriological point of view.
Ohnishi
K
K
Department of Infectious Diseases, Tokyo Metropolitan Bokutoh General Hospital, Tokyo, Japan. snow-crystal@msi.biglobe.ne.jp
Kimura
K
K
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004760:Enterocolitis / Q000188:drug therapy* / Q000382:microbiology; D005243:Feces / Q000382:microbiology; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D007564:Japan; D008297:Male; D008875:Middle Aged; D009287:Naphthyridines / Q000627:therapeutic use*; D012008:Recurrence; D012475:Salmonella / Q000302:isolation & purification; D012480:Salmonella Infections / Q000188:drug therapy*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; C055185:tosufloxacin