Tofisopam--evaluation of mutagenic and genotoxic properties.
The mutagenic properties of tofisopam, the member of the 2,3-benzodiazepine family, were evaluated on the basis of Ames test with Salmonella typhimurium TA1537, TA97, TA98, TA100 and TA102 strains. The genotoxic properties of tofisopam were estimated on L929 cell line with the cytokinesis-block technique. Under the experimental conditions, no mutagenic activity of tofisopam in tester bacteria strains was found, and no genotoxic activity was observed.
Chłopkiewicz
B
B
Drug Institute, 30/34 Chełmska Str., 00-725 Warsaw, Poland.
Ejchart
A
A
Anuszewska
E
E
D000818:Animals; D014151:Anti-Anxiety Agents / Q000633:toxicity*; D000928:Antidepressive Agents / Q000633:toxicity*; D001569:Benzodiazepines; D002460:Cell Line; D051379:Mice; D008809:Mice, Inbred C3H; D015162:Micronucleus Tests / Q000379:methods; D009152:Mutagenicity Tests / Q000379:methods; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000502:physiology
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001569:Benzodiazepines; C012582:tofisopam