title: Infectious crystalline keratopathy in an immunosuppressed patient.
abstract: OBJECTIVE
  To report a case of infectious crystalline keratopathy (ICK) in a patient with systemic malignancy on immunosuppressive chemotherapy. The patient wore frequent replacement contact lenses on an extended wear basis.
  
  
  METHODS
  A 51-year-old female with carcinoma of the breast and systemic metastases was referred for a corneal ulcer. She received intravenous docetaxel, trastuzumab, and systemic dexamethasone. She wore frequent replacement Acuvue lenses on an extended wear basis. Her visual acuity was 20/200 in the right eye and 20/400 in the left eye. The right eye examination revealed diffuse superficial punctate keratopathy. In the left eye, there was a 3.8 x 4.5 mm corneal infiltrate with projecting crystalline processes. Corneal scrapings were performed for smears and cultures. Treatment with topical fortified cefazolin and fortified tobramycin every hour around the clock was initiated.
  
  
  RESULTS
  Culture of the corneal scrapings grew Streptococcus anginosus and Staphylococcus aureus. There was a good response to medical therapy. When last seen after 4 weeks of treatment, the infiltrate measured about 1 mm and the visual acuity was 20/40 with pinhole.
  
  
  CONCLUSIONS
  Systemic immunosuppression may be a predisposing factor for the development of ICK. This case suggests that debilitated patients may be at risk for unusual infections and should be discouraged from overnight wear of contact lenses.
authors.affiliation: Cornea Service, Wills Eye Hospital, Philadelphia, PA 19107, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Sridhar
authors.forename: P R
authors.initials: PR
authors.lastname: Laibson
authors.forename: C J
authors.initials: CJ
authors.lastname: Rapuano
authors.forename: E J
authors.initials: EJ
authors.lastname: Cohen
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy; D002437:Cefazolin / Q000627:therapeutic use; D003261:Contact Lenses; D003315:Cornea / Q000382:microbiology; D003320:Corneal Ulcer / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D015818:Eye Infections, Bacterial / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D007165:Immunosuppression Therapy; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D013211:Staphylococcus aureus / Q000302:isolation & purification*; D013290:Streptococcal Infections / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology; D013291:Streptococcus / Q000302:isolation & purification*; D014031:Tobramycin / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D002437:Cefazolin; D014031:Tobramycin