Overexpression of p8 is inversely correlated with apoptosis in pancreatic cancer.
A recently identified gene, p8, has cell growth-promoting activity and is strongly induced in acute pancreatitis. In this study, we detected p8 and single-stranded DNA (ssDNA) for apoptosis by immunohistochemistry in human pancreatic cancer. The p8 was overexpressed (>30% per 1000 cancer cells) in 26 of 44 (59%) pancreatic cancers, and apoptosis (ssDNA-positive cells >10% per 1000 cancer cells) was recognized in 18 of 44 (41%) pancreatic cancers. There was a significant inverse correlation between the p8 overexpression and apoptosis (P < 0.05). Moreover, the expression pattern of high p8 and low ssDNA was seen significantly more often in lower age (<65 years), in moderately or poorly differentiated cancers, and in node-positive cases (P < 0.05). The p8 expression and apoptosis were not significantly correlated with survival. These results suggest that p8 overexpression is involved in antiapoptotic activity and the biological characteristics of pancreatic cancer.
Su
S B
SB
Department of Internal Medicine and Medical Oncology, Cancer Research Institute, Kanazawa University, Kanazawa 921-8044, Japan.
Motoo
Y
Y
Iovanna
J L
JL
Berthézène
P
P
Xie
M J
MJ
Mouri
H
H
Ohtsubo
K
K
Matsubara
F
F
Sawabu
N
N
D000368:Aged; D000369:Aged, 80 and over; D017209:Apoptosis / Q000235:genetics*; D051792:Basic Helix-Loop-Helix Proteins; D006690:Bisbenzimidazole; D004273:DNA, Neoplasm / Q000032:analysis; D004277:DNA, Single-Stranded / Q000032:analysis; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000502:physiology; D005260:Female; D005456:Fluorescent Dyes; D015870:Gene Expression; D006133:Growth Substances / Q000096:biosynthesis* / Q000502:physiology; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins; D010190:Pancreatic Neoplasms / Q000235:genetics / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D016019:Survival Analysis
D051792:Basic Helix-Loop-Helix Proteins; D006690:Bisbenzimidazole; D004273:DNA, Neoplasm; D004277:DNA, Single-Stranded; D004268:DNA-Binding Proteins; D005456:Fluorescent Dyes; D006133:Growth Substances; D009363:Neoplasm Proteins; C491643:NUPR1 protein, human