Recalibration of the point-of-care test for CARDIAC T Quantitative with Elecsys Troponin T 3rd generation.
The rapid troponin T assay CARDIAC T Quantitative was recalibrated using Elecsys Troponin T 3rd Generation as a new reference method. This paper presents the method comparisons at six centres using the new reference method. Method comparison between CARDIAC T Quantitative versus Elecsys Troponin T 3rd Generation were performed using 319 samples from patients with acute coronary syndromes. The quality of the CARDIAC T Quantitative was controlled by a daily single determination of CARDIAC Control Troponin T, and for the Elecsys Troponin T 3rd Generation, the Elecsys controls were included in each run. The results for the control materials for the CARDIAC T Quantitative were between 93% and 107% of the target values. The CV ranged from 7% to 16%. From the regression analysis, according to Bablok and Passing (y=1.07x) and the Bland and Altman plot, the bias between CARDIAC T Quantitative and Elecsys Troponin T 3rd Generation is from +6% to +7%. The correlation coefficient is 0.93, and a 3x3 comparison of the clinical efficiency yielded 92% clinical concordance between CARDIAC T Quantitative and Elecsys Troponin T 3rd Generation. In conclusion, CARDIAC T Quantitative was in good agreement with the reference and calibration method Elecsys Troponin T 3rd Generation.
Collinson
P O
PO
Department of Pathology, Mayday University Hospital, London, UK.
Jørgensen
B
B
Sylvén
C
C
Haass
M
M
Chwallek
F
F
Katus
H A
HA
Müller-Bardorff
M
M
Derhaschnig
U
U
Hirschl
M M
MM
Zerback
R
R
D002138:Calibration; D019963:Clinical Chemistry Tests / Q000592:standards*; D006801:Humans; D019095:Point-of-Care Systems / Q000592:standards*; D011786:Quality Control; D012015:Reference Standards; D020107:Troponin T / Q000097:blood* / Q000592:standards
D020107:Troponin T