Microbial hydroxylation and reduction of the diterpene psiadin.
Microbial bioconversion studies conducted on the diterpene psiadin have revealed that it was metabolized by Aspergillus niger (NRRL 2295) to give 2alpha-hydroxydeoxopsiadin, Cunninghamella blakesleeana (ATCC 8688a) to give 11beta-hydroxypsiadin, and Cylindrocephalum aureum (ATCC 12720), Gongronella butleri (ATCC 22822), Kloeckera africana (ATCC 20111), and Kluyveromyces marxianus var. lactis (ATCC 2628) to yield 7alpha-hydroxypsiadin. Their structures have been established on the basis of spectral data. The structure and relative stereochemistry of 7alpha-hydroxypsiadin was confirmed by single-crystal X-ray analysis.
Orabi
K Y
KY
Department of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia. kyorabi@ksu.edu.sa
Galal
A M
AM
Ibrahim
A R
AR
El-Feraly
F S
FS
McPhail
A T
AT
D001234:Aspergillus niger / Q000378:metabolism; D001711:Biotransformation; D020093:Cunninghamella / Q000378:metabolism; D004224:Diterpenes / Q000737:chemistry / Q000378:metabolism*; D005285:Fermentation; D005658:Fungi / Q000378:metabolism*; D006900:Hydroxylation; D007716:Kluyveromyces / Q000378:metabolism; D008958:Models, Molecular; D008968:Molecular Conformation; D010084:Oxidation-Reduction
D004224:Diterpenes; C432467:psiadin