The role of orlistat in weight management.
BACKGROUND
Most antiobesity drugs act centrally to reduce appetite or increase satiety. Orlistat is the first in a new class of drugs targeted at a single dietary component, in this case dietary fat.


OBJECTIVE
To review the clinical actions and efficacy of orlistat and to discuss its place in overall weight management.


CONCLUSIONS
Orlistat is best used in long term weight management as an adjunct to dietary modification and increased physical activity. The reduction in fat absorption results in a slow but sustained weight reduction and improved metabolic parameters such as reduced total, and LDL cholesterol. Side effects are minimised by maintaining a low fat diet.
Marks
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Monash Medical Centre, Melbourne, Victoria.
D019440:Anti-Obesity Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001315:Australia; D001361:Avitaminosis / Q000139:chemically induced; D002784:Cholesterol / Q000097:blood; D006801:Humans; D007783:Lactones / Q000009:adverse effects / Q000627:therapeutic use*; D009765:Obesity / Q000188:drug therapy*; D000077403:Orlistat
D019440:Anti-Obesity Agents; D007783:Lactones; D000077403:Orlistat; D002784:Cholesterol