Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554.
A novel compound, nafuredin, was isolated as an inhibitor of anaerobic electron transport (NADH-fumarate reductase). It was obtained from culture broth of Aspergillus niger FT-0554 isolated from a marine sponge. The structure was elucidated as an epoxy-delta-lactone with an attached methylated olefinic side chain on the basis of spectral analysis.
Ui
H
H
Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.
Shiomi
K
K
Yamaguchi
Y
Y
Masuma
R
R
Nagamitsu
T
T
Takano
D
D
Sunazuka
T
T
Namikoshi
M
M
Omura
S
S
D001234:Aspergillus niger / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011753:Pyrones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
D004791:Enzyme Inhibitors; D011753:Pyrones; C423563:nafuredin; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; C020155:fumarate reductase (NADH)