New advances in the understanding of the role of steroids and steroid receptors in disease.
Steroids and related compounds are important in disease development and prevention, via steroid receptor-mediated and receptor-independent mechanisms. Interaction of endogenous oestrogens with the oestrogen receptor has unfortunate mitogenic effects in breast cancer. However, dietary consumption of non-steroidal weak oestrogens, such as the soy isoflavone phytoestrogens genistein and diadzein, is associated with a decreased breast cancer risk. This may arise in part from the suboptimal configuration induced in the transactivation helix of oestrogen receptor-beta.
Wiseman
H
H
Department of Nutrition and Dietetics, Nutrition, Food and Health Research Centre. King's College London, Franklin-Wilkins Building, 150 Stamford Street, London SE1 9NN, U.K. helen.wiseman@kcl.ac.uk
Duffy
R
R
D000818:Animals; D004194:Disease; D004967:Estrogens / Q000378:metabolism; D006801:Humans; D010121:Oxytocin / Q000378:metabolism; D011944:Receptors, Androgen / Q000378:metabolism; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D018045:Receptors, Oxytocin / Q000378:metabolism; D011987:Receptors, Steroid / Q000378:metabolism*; D011988:Receptors, Thyroid Hormone / Q000378:metabolism; D013256:Steroids / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism
D004967:Estrogens; D011944:Receptors, Androgen; D018160:Receptors, Cytoplasmic and Nuclear; D011960:Receptors, Estrogen; D018045:Receptors, Oxytocin; D011987:Receptors, Steroid; D011988:Receptors, Thyroid Hormone; D013256:Steroids; D014157:Transcription Factors; D010121:Oxytocin