title: Association between wall shear stress and flow-mediated vasodilation in healthy men.
abstract: Wall shear stress contributes to the endothelial production of vasoactive mediators, like nitric oxide (NO). Brachial artery vasodilation that follows increased blood flow is regulated by NO release. Aim of the present study was to investigate whether resting wall shear stress of the brachial artery is related to flow-mediated vasodilation (FMD) induced by forearm ischemia. Wall shear stress was calculated according to the following formula: Wall shear stress=Blood viscosity x Blood velocity/Internal diameter. FMD was calculated as percentage change of brachial artery diameter following forearm ischemia. Twenty-seven healthy male subjects were investigated. Peak wall shear stress and FMD were 37.3+/-12.8 dynes/cm(2) and 110.7+/-5.6%, respectively (mean+/-S.D.). In simple regression analyses, age was inversely associated with wall shear stress (r=48, P<0.01) and, marginally, with FMD (r=0.33, P=0.08). Wall shear stress and FMD were directly related (r=0.60, P<0.001). In multiple regression analysis, including wall shear stress, age, blood pressure, lipids, glucose and Body Mass Index as independent variables, wall shear stress was the only variable independently associated with FMD (standardized beta coefficient=0.690, P</=0.005). To avoid the influence of brachial artery size on FMD, the regression analysis was restricted to subjects with similar diameter (n=12). In these subjects wall shear stress continued to be significantly associated with FMD (r=0.69, P=0.01). Our results demonstrate a strong association between resting wall shear stress and FMD in the brachial artery in healthy men in vivo. This association is independent of age and vessel diameter.
authors.affiliation: Dipartimento di Medicina Sperimentale e Clinica, University of Catanzaro Magna Graecia, Policlinico Mater Domini, Centro Aterosclerosi, via T.Campanella, 88100 Catanzaro, Italy. gnasso@mailexcite.com
authors.forename: A
authors.initials: A
authors.lastname: Gnasso
authors.forename: C
authors.initials: C
authors.lastname: Carallo
authors.forename: C
authors.initials: C
authors.lastname: Irace
authors.forename: M S
authors.initials: MS
authors.lastname: De Franceschi
authors.forename: P L
authors.initials: PL
authors.lastname: Mattioli
authors.forename: C
authors.initials: C
authors.lastname: Motti
authors.forename: C
authors.initials: C
authors.lastname: Cortese
mesh_terms: D000328:Adult; D000368:Aged; D001809:Blood Viscosity / Q000502:physiology; D001916:Brachial Artery / Q000502:physiology* / Q000503:physiopathology; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007511:Ischemia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology; D013314:Stress, Mechanical; D014664:Vasodilation / Q000502:physiology*