title: [Rapid effect of glucocorticoid on excitatory postsynaptic potential of B cells in bullfrog paravertebral ganglia].
abstract: In the present study, the rapid effect of hydrocortisone 21-hemisuccinate (F-suc) on the amplitude of f-EPSP of B cells in isolated bullfrog sympathetic ganglia was examined with the use of intracellular recording technique. It was found that the amplitude of f-EPSP of B cells was decreased by F-suc, with a latency less than 3 min after the beginning of perfusion of F-suc. The inhibition of F-suc was concentration-dependent and could be blocked by the antagonist of intracellular glucocorticoid receptor RU38486, but not by the protein synthesis inhibitor actidione. These findings suggest that the inhibition of f-EPSP of B cells by F-suc is probably mediated through a nongenomic mechanism.
authors.affiliation: Department of Physiology, Second Military Medical University, Shanghai 200433.
authors.forename: B
authors.initials: B
authors.lastname: Ma
authors.forename: B D
authors.initials: BD
authors.lastname: Yi
authors.forename: B R
authors.initials: BR
authors.lastname: Xing
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000502:physiology; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects*; D005260:Female; D005726:Ganglia, Parasympathetic / Q000166:cytology / Q000502:physiology*; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D011892:Rana catesbeiana
chemical_list: C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone