title: Cancer chemotherapy--ribonucleases to the rescue.
abstract: Ribonucleases, once dismissed as uninteresting digestive enzymes, have been shown to have remarkable biological activities. Onconase, from the Northern leopard frog, is currently in clinical trials as a cancer chemotherapeutic. Recent research has revealed some key factors responsible for the cytotoxicity of ribonucleases, and may lead to a new class of drugs.
authors.affiliation: Department of Biochemistry, University of Wisconsin-Madison, 53706, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Leland
authors.forename: R T
authors.initials: RT
authors.lastname: Raines
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003600:Cytosol / Q000201:enzymology / Q000648:ultrastructure; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009865:Oocytes / Q000166:cytology / Q000201:enzymology; D011898:Ranidae / Q000196:embryology; D012259:Ribonuclease, Pancreatic / Q000494:pharmacology / Q000627:therapeutic use; D012260:Ribonucleases / Q000494:pharmacology* / Q000627:therapeutic use* / Q000633:toxicity; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D012260:Ribonucleases; D012259:Ribonuclease, Pancreatic; C058703:ranpirnase