title: Cytogenetic study of six cases of radiation-induced meningiomas.
abstract: It is known that, following radiotherapy, secondary cancer may occur after a long latent period. Few cytogenetic studies have been reported on tumors of the central nervous system occurring after radiotherapy. We report the cytogenetic study of six cases of radiation-induced meningiomas. In all cases, we observed the same chromosome abnormality, der(1)(1qter-->1p11::22q12-->22pter). SKY and CGH techniques allowed us to identify the chromosomal abnormalities. We suggest that a gene localized on 1p13 is involved in radiation-induced meningiomas.
authors.affiliation: Cytogenetic Oncology Laboratory, C.H.U. Timone-Marseille 264, Rue Saint-Pierre, 13385, Marseille Cedex 5, France.
authors.forename: H
authors.initials: H
authors.lastname: Zattara-Cannoni
authors.forename: P
authors.initials: P
authors.lastname: Roll
authors.forename: D
authors.initials: D
authors.lastname: Figarella-Branger
authors.forename: G
authors.initials: G
authors.lastname: Lena
authors.forename: H
authors.initials: H
authors.lastname: Dufour
authors.forename: F
authors.initials: F
authors.lastname: Grisoli
authors.forename: A M
authors.initials: AM
authors.lastname: Vagner-Capodano
mesh_terms: D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D007621:Karyotyping; D008577:Meningeal Neoplasms / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D008579:Meningioma / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000235:genetics* / Q000473:pathology; D009693:Nucleic Acid Hybridization