title: Cephaibols, new peptaibol antibiotics with anthelmintic properties from Acremonium tubakii DSM 12774.
abstract: Two groups of new peptaibol-type antibiotics termed cephaibols have been isolated from the fungus Acremonium tubakii, DSM 12774. These 16- or 17-unit straight-chain peptides, whose structures were characterized by amino acid analyses, 2-D NMR experiments, and by mass spectrometric sequencing, have a high content of the unusual amino acids aminoisobutyric acid and isovaline. The principal constituent of the novel peptaibol mixture is cephaibol A, which is formed in abundance in cultures of the wild strain. The striking biological property of cephaibol A is its pronounced anthelmintic action and activity against ectoparasites.
authors.affiliation: Aventis Pharma Deutschland GmbH, Division Lead Generation, Frankfurt/Main, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Schiell
authors.forename: J
authors.initials: J
authors.lastname: Hofmann
authors.forename: M
authors.initials: M
authors.lastname: Kurz
authors.forename: F R
authors.initials: FR
authors.lastname: Schmidt
authors.forename: L
authors.initials: L
authors.lastname: Vértesy
authors.forename: M
authors.initials: M
authors.lastname: Vogel
authors.forename: J
authors.initials: J
authors.lastname: Wink
authors.forename: G
authors.initials: G
authors.lastname: Seibert
mesh_terms: D000164:Acremonium / Q000737:chemistry*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000871:Anthelmintics / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001197:Ascaridia / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008969:Molecular Sequence Data; D015394:Molecular Structure; D010455:Peptides
chemical_list: D000596:Amino Acids; D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D010455:Peptides