Thrombotic thrombocytopenic purpura in HIV infection: a report of two cases.
Thrombotic thrombocytopenic purpura (TTP) is a rare but well-described complication of HIV infection, which occurs equally frequently during the early asymptomatic phase of HIV infection and with clinical AIDS. The clinical spectrum varies from a low-grade asymptomatic thrombocytopenia with mild renal insufficiency to a catastrophic illness with gross neurological deficits and renal failure requiring dialysis. We report two cases of TTP associated with HIV infection seen in our institution over a period of 2 years. The clinical course of these two patients highlights the markedly heterogeneous characteristics of patients with HIV-related TTP. HIV infection may be the most common association of TTP in certain communities with a high prevalence of HIV infection. As early diagnosis and institution of plasmapheresis is crucial for a favorable outcome it is important to be aware of this association.
Sood
R
R
Roswell Park Cancer Institute, Buffalo, NY, USA.
Rakkar
A S
AS
Carmosino
L
L
Mir
T
T
Khan
F A
FA
D058186:Acute Kidney Injury / Q000821:virology; D000328:Adult; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D011379:Prognosis; D011697:Purpura, Thrombotic Thrombocytopenic / Q000175:diagnosis / Q000628:therapy / Q000821:virology*