[Excess of mineralocorticoids in essential hypertension: clinical-diagnostic approach].
BACKGROUND
Primary hyperaldosteronism is more frequent among subjects with essential hypertension than previously thought. The prevalence, according to local and international evidence could fluctuate between 9 and 10%.


OBJECTIVE
To investigate if subjects with essential hypertension have different aldosterone and renin plasma levels than normotensive subjects.


METHODS
One hundred twenty five subjects with essential hypertension, not receiving medications for at least two weeks prior to the study and 168 age and sex matched normotensive controls were studied. Blood was drawn between 9 and 10 AM during a sodium free diet to determine plasma aldosterone, plasma renin activity and potassium.


RESULTS
Plasma aldosterone was higher in hypertensive subjects than controls (11.6 +/- 7.6 and 9.9 +/- 5.1 ng/dl respectively; p = 0.04). Plasma renin activity was lower in hypertensives than controls (1.42 +/- 1.28 and 1.88 +/- 1.39 ng/ml/b respectively; p < 0.001). Thus, plasma aldosterone/plasma renin activity ratio was higher in hypertensives (13.8 +/- 13.5 and 8.3 +/- 7.8; p < 0.001). A pathological ratio was defined as over 25, corresponding to the mean plus two standard deviations of the control group. Primary hyperaldosteronism was found in 5/125 hypertensives (4%) and 1/168 normotensive subject (0.6%). None had hypokalemia.


CONCLUSIONS
Subjects with essential hypertension have higher plasma aldosterone and lower plasma renin activity than normal controls. A plasma aldosterone/plasma renin activity over 25 was defined as abnormal.
Cortés
P
P
Departamentos de Endocrinología, Medicina Interna y Unidad de Laboratorios Clínicos, Facultad de Medicina, Pontificia Universidad Católica de Chile.
Fardella
C
C
Oestreicher
E
E
Gac
H
H
Mosso
L
L
Soto
J
J
Foradori
A
A
Claverie
X
X
Ahuad
J
J
Montero
J
J
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood*; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000097:blood*; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012016:Reference Values; D012083:Renin / Q000097:blood*
D000450:Aldosterone; D012083:Renin; D011188:Potassium