A three-dimensional, quantitative computed tomographic study of changes in distribution of bone mineralization in the developing human mandible.
The three-dimensional distribution of highly mineralized cortical bone on the buccal surface of the mandible was evaluated using quantitative computed tomography. The study was completed in 34 living persons (21 females and 13 males) between the ages of 9 and 32 yr of age with symmetrical mandibles. The geometrical distribution of the highly mineralized areas (>1250 mg/cm(3)) was determined by three-dimensional reconstruction of images. The pattern of distribution was evaluated by superimposing a 9 by 9-mesh grid over the lateral view of the mandible and adapting it to the same anatomical landmarks for different aged participants. Individuals demonstrated four different patterns of distribution of highly mineralized buccal cortical bone. The youngest had highly mineralized bone in the corpus of the mandible and along the anterior ramal border. In older individuals, the mineralization changed to include the mid- and posterior ramus. Highly mineralized bone was not found within the condylar, coronoid, or gonial angle regions of any participant. A comparison of the mineralization pattern between the left and right lateral mandibular views showed bilateral symmetry with similar patterns of distribution. Comparison of the number of grids occupied by highly mineralized cortical bone with the age of the participant, mandibular length, gonial angle, and cross-sectional area of the masseter muscle produced the highest correlation coefficient with the size of the masseter muscle.
Maki
K
K
Department of Growth and Development, School of Dentistry, University of California at San Francisco, San Francisco, CA 94143-0438, USA.
Miller
A J
AJ
Okano
T
T
Shibasaki
Y
Y
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D002113:Calcification, Physiologic / Q000502:physiology*; D002648:Child; D005260:Female; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000254:growth & development*; D008406:Masseter Muscle / Q000033:anatomy & histology; D018709:Statistics, Nonparametric; D014057:Tomography, X-Ray Computed / Q000379:methods