title: Plasma levels of immunoinflammatory markers in De Novo coronary atherosclerosis and coronary restenosis postangioplasty.
abstract: OBJECTIVE
  To compare circulating plasma levels of immunoinflammatory markers in patients with known de novo coronary artery disease and patients with postangioplasty restenosis.
  
  
  METHODS
  Using enzymatic immunoabsorbent assay, we measured plasma levels of soluble interleukin-2 receptosr, tumor necrosis factor alpha, and soluble tumor necrosis alpha receptors I and II in 11 patients with restenosis postcoronary angioplasty (restenosis group), in 10 patients with primary atherosclerosis (de novo group) who were referred for coronary angiography because of stable or unstable angina, and in 9 healthy volunteers (control group). Levels of soluble interleukin-2 receptors were significantly higher in the de novo group compared with that in the restenosis and control groups. Levels were also higher in the restenosis group compared with that in the control group. Plasma levels of tumor necrosis alpha and receptor levels were significantly higher in the de novo group compared to with that in the restenosis and control groups, but levels in the restenosis group were not different from that in the controls.
  
  
  CONCLUSIONS
  Coronary artery disease, either primary or secondary to restenosis, is associated with significant immunoinflammatory activity, which can be assessed by examining the extent of circulating plasma levels of inflammatory markers. Moreover, patients with de novo lesions appear to have increased inflammatory activity compared with patients with restenosis.
authors.affiliation: Hospital de Clínicas de Porto Alegre, Federal University of Rio Grande do Sul, Porto Alegre, RS, 90035-003, Brazil.
authors.forename: A S
authors.initials: AS
authors.lastname: Quadros
authors.forename: J P
authors.initials: JP
authors.lastname: Ribeiro
authors.forename: W C
authors.initials: WC
authors.lastname: Manfroi
authors.forename: C
authors.initials: C
authors.lastname: Leitão
authors.forename: K
authors.initials: K
authors.lastname: Ordovás
authors.forename: L
authors.initials: L
authors.lastname: Weiss
authors.forename: N
authors.initials: N
authors.lastname: Clausell
mesh_terms: D000704:Analysis of Variance; D000800:Angioplasty, Balloon; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D003324:Coronary Artery Disease / Q000097:blood*; D003327:Coronary Disease / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D015375:Receptors, Interleukin-2 / Q000097:blood*; D012008:Recurrence; D018709:Statistics, Nonparametric; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D015415:Biomarkers; D015375:Receptors, Interleukin-2; D014409:Tumor Necrosis Factor-alpha