Nitrate esters as nitric oxide donors: SS-nitrates.
[structure: see text]. The important biological secondary messenger NO can be generated from exogenous nitrovasodilators and NO donors. Nitrate esters are nitrovasodilators and NO mimetics, believed to be biotransformed to NO in vivo. On the basis of a mechanistic hypothesis, nitrates have been synthesized that release NO at significant rates in neutral aqueous solution in the presence only of added thiol. The novel masked beta-mercaptonitrates reported (SS-nitrates), provide information on possible sulfhydryl-dependent biotransformation mechanisms for nitrates in clinical use.
Zavorin
S I
SI
Department of Chemistry, Queen's University, Kingston, Ontario K7L 3N6, Canada.
Artz
J D
JD
Dumitrascu
A
A
Nicolescu
A
A
Scutaru
D
D
Smith
S V
SV
Thatcher
G R
GR
D004563:Electrochemistry; D004952:Esters / Q000737:chemistry*; D008956:Models, Chemical; D009569:Nitric Oxide / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry
D004952:Esters; D013438:Sulfhydryl Compounds; D009569:Nitric Oxide