title: Aging cohort of perinatally human immunodeficiency virus-infected children in New York City. New York City Pediatric Surveillance of Disease Consortium.
abstract: BACKGROUND
  New York City (NYC) pediatricians are now caring for fewer HIV-infected infants and more school age children and adolescents than earlier in the epidemic.
  
  
  METHODS
  Clinical, laboratory and demographic data were abstracted from medical records at 10 NYC centers participating in the CDC Pediatric Spectrum of HIV Disease project. Pediatric AIDS cases and HIV-related deaths reported to the NYC Department of Health were examined.
  
  
  RESULTS
  Median age of HIV-infected children in care increased from 3 years in 1989 to 1991 to 6 years in 1995 to 1998. The number of HIV-infected women giving birth in NYC declined 50% from 1990 to 1997 (1630 to 831); increasing numbers were identified prenatally (14% in 1989; 78% after 1995); and most received prenatal zidovudine prophylaxis (73% in 1997). Estimated perinatal transmission decreased to 10% by 1997. Improved identification of seropositive status in infants was associated with an increased proportion of infected infants receiving Pneumocystis carinii pneumonia (PCP) prophylaxis, 84% in 1997. AIDS free survival was longer for children born 1995 to 1998 than for those born before 1995, P = 0.004. In 1998 among children with advanced immunosuppression (CDC category 3), 66% were prescribed 3 or more antiretroviral medicines and 88% received PCP prophylaxis. Citywide AIDS cases and HIV-related deaths fell precipitously beginning in 1996.
  
  
  CONCLUSIONS
  Based on the observations of this study, the cohort of NYC HIV-infected children in care is aging, associated with a decline in new HIV infections, high rates of PCP prophylaxis and increased time to AIDS. Falling HIV-related deaths citywide support these observations.
authors.affiliation: Harlem Hospital Center, Columbia University, College of Physicians and Surgeons, New York, NY, USA. eja1@columbia.edu
authors.forename: E J
authors.initials: EJ
authors.lastname: Abrams
authors.forename: J
authors.initials: J
authors.lastname: Weedon
authors.forename: J
authors.initials: J
authors.lastname: Bertolli
authors.forename: K
authors.initials: K
authors.lastname: Bornschlegel
authors.forename: J
authors.initials: J
authors.lastname: Cervia
authors.forename: H
authors.initials: H
authors.lastname: Mendez
authors.forename: G
authors.initials: G
authors.lastname: Lambert
authors.forename: T
authors.initials: T
authors.lastname: Singh
authors.forename: P
authors.initials: P
authors.lastname: Thomas
mesh_terms: D000375:Aging; D023241:Antiretroviral Therapy, Highly Active; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology* / Q000635:transmission*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D015166:Monitoring, Immunologic; D009519:New York City / Q000453:epidemiology; D011247:Pregnancy; D015996:Survival Rate; D013997:Time Factors