title: Validation of CBF measurement with non-invasive microsphere method (NIMS) compared with autoradiography method (ARG).
abstract: The purpose of this study is to examine the correlation of measured regional cerebral blood flow (rCBF) by means of a new microsphere method (non-invasive microsphere method), to the autoradiography (ARG) method, which is an established quantification method for 123I-IMP brain SPECT. The non-invasive microsphere (NIMS) method and ARG method were simultaneously applied to 30 patients, and quantified rCBF maps were calculated with each method. A significant correlation (r = 0.70: p < 0.001) was detected between mCBF values calculated with the NIMS and ARG methods. This new method seems to reliably quantify rCBF with brain SPECT.
authors.affiliation: Department of Radiology, Teikyo University School of Medicine, Tokyo, Japan. kami@med.teikyo-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Kaminaga
authors.forename: N
authors.initials: N
authors.lastname: Kunimatsu
authors.forename: T
authors.initials: T
authors.lastname: Chikamatsu
authors.forename: S
authors.initials: S
authors.lastname: Furui
mesh_terms: D001345:Autoradiography / Q000379:methods; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D004244:Dizziness / Q000000981:diagnostic imaging / Q000503:physiopathology*; D015673:Fatigue Syndrome, Chronic / Q000000981:diagnostic imaging / Q000503:physiopathology*; D005260:Female; D006261:Headache / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006801:Humans; D020367:Iofetamine; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D011859:Radiography; D019275:Radiopharmaceuticals; D012044:Regression Analysis; D015203:Reproducibility of Results; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D020367:Iofetamine