Strain-dependency of chromosomal abnormalities in lymphomas developed in E mu-myc transgenic mice.
We previously showed that B and T cell lymphoma development in Em (immunoglobulin heavy chain enhancer)-myc transgenic mice is dependent on the mouse strain. To determine whether any non-random chromosomal abnormality that was present was caused by variations in the lymphoma cell type or by a different genetic background, we crossed C3H transgenic mice with other inbred strains of mice, C57BL / 6 or BALB / c. Cytogenetic analysis showed a high frequency of non-random chromosomal aberrations, namely, duplication or amplification of part of chromosome 5 containing the transgene and trisomy of chromosome 1, 6, or 12 in the genetic background of C3H x C57BL / 6 mouse and C3H x BALB / c mouse, respectively, regardless of cell type of lymphoma. These results suggest that non-random chromosomal abnormalities in lymphoma cells are dependent on the genetic background of mouse, not on the tumor cell type in Em-myc transgenic mouse.
Akagi
K
K
Saitama Cancer Center Research Institute, Ina, Kitaadachigun, Saitama 362-0806, Japan. akagi@cancer-c.pref.saitama.jp
Yamamura
K
K
D000818:Animals; D002869:Chromosome Aberrations; D004742:Enhancer Elements, Genetic / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D017403:In Situ Hybridization; D007621:Karyotyping; D008223:Lymphoma / Q000235:genetics*; D016393:Lymphoma, B-Cell / Q000235:genetics; D016399:Lymphoma, T-Cell / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008822:Mice, Transgenic; D010954:Plasmacytoma / Q000235:genetics; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics*; D013045:Species Specificity
D007143:Immunoglobulin Heavy Chains; D016271:Proto-Oncogene Proteins c-myc