[Fatal lactic acidosis in a patient with acquired immunodeficiency syndrome treated with highly active antiretroviral therapy. Report of a case].
Type B lactic acidosis occurs without any evidence of cellular hypoxia and is associated with the use of drugs or toxins. We report a 36 years old woman with acquired immunodeficiency syndrome that was admitted to the hospital with a severe lactic acidosis. She had been treated with didanosine, stavudine and efavirenz for four months prior to admission. Despite the use of high bicarbonate doses and vasoactive drugs, the patient had a catastrophic evolution and died in shock and multiple organ failure, 68 hours after admission. (Rev Méd Chile 2000; 128: 1139-43).
Lasso
M
M
Hospital Dr. Sótero del Río, Puente Alto, Santiago, Fundación Arriaran, Santiago, Chile.
Pérez
J
J
Noriega
L M
LM
Northland
R
R
D000140:Acidosis, Lactic / Q000139:chemically induced*; D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy*; D000328:Adult; D000480:Alkynes; D019380:Anti-HIV Agents / Q000009:adverse effects*; D048588:Benzoxazines; D003521:Cyclopropanes; D016049:Didanosine / Q000009:adverse effects; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D010078:Oxazines / Q000009:adverse effects; D012720:Severity of Illness Index; D018119:Stavudine / Q000009:adverse effects
D000480:Alkynes; D019380:Anti-HIV Agents; D048588:Benzoxazines; D003521:Cyclopropanes; D010078:Oxazines; D018119:Stavudine; C098320:efavirenz; D016049:Didanosine