[Comparative study on the effect of gossypol and T7 on human spermatozoa ATPase activity].
OBJECTIVE
A comparative study was carried out on the effect of two kinds of male contraceptive drugs, gossypol and the abstract of tripterygium wilfordii T7, on the human spermatozoa ATPase activity.


METHODS
The specific activity of total ATPase and Na-K ATPase of spermatozoa was assayed in this experiment.


RESULTS
(1) The effect of gossypol on the human spermatozoa ATPase activity is inhibitory and concentration-dependent; and (2) The abstract of tripterygium wilfodii T7 has no effect on the human spermatozoa ATPase activity.


CONCLUSIONS
The antifertility effects of gossypol and T7 are different.
Wu
F
F
Institute of Basic Medical Sciences, Beijing 100005.
Zhang
Z
Z
Ye
W
W
Qian
X
X
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000988:Antispermatogenic Agents / Q000494:pharmacology*; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006072:Gossypol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D013094:Spermatozoa / Q000187:drug effects / Q000201:enzymology*; D029757:Tripterygium
D000988:Antispermatogenic Agents; D003272:Contraceptive Agents, Male; D004365:Drugs, Chinese Herbal; D000251:Adenosine Triphosphatases; D006072:Gossypol