Preliminary evaluation of thyroid C cells in rats with chronic renal failure.
Numerous water-electrolyte and hormonal disturbances, including secondary hyperparathyroidism, occur in the course of chronic renal failure. It is assumed that chronic renal failure should affect the activity of C cells in the thyroid gland. Thus, the aim of the study was to evaluate immunohistochemically thyroid C cells in rats with experimental uremia. 30 days after nephrectomy, thyroid fragments were collected from experimental rats. Paraffin embedded sections were stained with H+E and by silver impregnation. Calcitonin (CT), synaptophysin (SY), somatostatin (ST), and neuron-specific enolase (NSE) were detected immunohistochemically in the C cells. A very distinct increase in C cell number in the thyroid and the weakening of majority of examined reactions were observed in rats with experimental uremia.
Azzadin
A
A
Department of Pharmacodynamics, Medical Academy, Białystok, Poland. shwan@interia.pl
Kasacka
I
I
Sawicki
B
B
Dadan
J
J
Malla
H
H
Buczko
W
W
D000818:Animals; D007150:Immunohistochemistry; D007676:Kidney Failure, Chronic / Q000473:pathology*; D008297:Male; D009392:Nephrectomy; D016612:Paraffin Embedding; D051381:Rats; D017208:Rats, Wistar; D013194:Staining and Labeling; D013961:Thyroid Gland / Q000473:pathology*