Activity of a trinuclear platinum complex in human ovarian cancer cell lines sensitive and resistant to cisplatin: cytotoxicity and induction and gene-specific repair of DNA lesions.
A collateral sensitivity or a very modest cross-resistance to BBR 3464 was found in 2 ovarian cancer cell lines with experimentally induced resistance to cisplatin. Loss of mismatch repair proteins (hMLH1, hPMS2) or overexpression of nucleotide excision repair proteins (ERCC1) was not detrimental for the cellular sensitivity to BBR 3464. Moreover, interesting differences in the kinetics of formation and removal of DNA lesions at the single-gene (N- ras) level were observed between BBR 3464 and CDDP.
Colella
G
G
Department of Experimental Oncology, Istituto Nazionale per lo Studio e la Cura dei Tumori, Via Venezian 1, 20133 Milan, Italy.
Pennati
M
M
Bearzatto
A
A
Leone
R
R
Colangelo
D
D
Manzotti
C
C
Daidone
M G
MG
Zaffaroni
N
N
D048868:Adaptor Proteins, Signal Transducing; D000251:Adenosine Triphosphatases; D000970:Antineoplastic Agents / Q000633:toxicity*; D020137:Base Pair Mismatch; D002352:Carrier Proteins; D002470:Cell Survival / Q000187:drug effects*; D002945:Cisplatin / Q000633:toxicity*; D004260:DNA Repair / Q000187:drug effects / Q000235:genetics*; D045643:DNA Repair Enzymes; D004268:DNA-Binding Proteins; D019008:Drug Resistance, Neoplasm; D004720:Endonucleases; D005260:Female; D006801:Humans; D000070976:Mismatch Repair Endonuclease PMS2; D000070957:MutL Protein Homolog 1; D009363:Neoplasm Proteins / Q000235:genetics; D009687:Nuclear Proteins; D009944:Organoplatinum Compounds / Q000633:toxicity*; D010051:Ovarian Neoplasms; D016133:Polymerase Chain Reaction; D011506:Proteins / Q000235:genetics; D014407:Tumor Cells, Cultured
D048868:Adaptor Proteins, Signal Transducing; D000970:Antineoplastic Agents; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; C501486:MLH1 protein, human; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D009944:Organoplatinum Compounds; D011506:Proteins; C071447:ERCC1 protein, human; D004720:Endonucleases; D000251:Adenosine Triphosphatases; C094934:PMS2 protein, human; D000070976:Mismatch Repair Endonuclease PMS2; D000070957:MutL Protein Homolog 1; D045643:DNA Repair Enzymes; C114062:BBR 3464; D002945:Cisplatin