Isolation of an unknown metabolite of the non-steroidal anti-inflammatory drug etodolac and its identification as 5-hydroxy etodolac.
The non-steroidal anti-inflammatory drug etodolac is extensively metabolized in the liver. Renal elimination of etodolac mainly as glucuronide and its other phase I and phase II metabolites is the primary route of excretion. High-performance liquid chromatography assays of human urine after application of etodolac indicated the existence of a further monohydroxylated metabolite (metabolite X) that was identified as 5-hydroxy etodolac. For the identification, electrospray ionization mass spectrometry (ESI-MS) as well as 1H-nuclear magnetic resonance (1H-NMR) and 13C-NMR spectroscopy have been used.
Strickmann
D B
DB
Institute of Pharmaceutical Chemistry, University of Münster, Hittorfstrasse 58-62, 48149, Münster, Germany.
Blaschke
G
G
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism* / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D017308:Etodolac / Q000031:analogs & derivatives / Q000302:isolation & purification* / Q000378:metabolism* / Q000652:urine; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D021241:Spectrometry, Mass, Electrospray Ionization
C435718:5-hydroxyetodolac; D000894:Anti-Inflammatory Agents, Non-Steroidal; D017308:Etodolac