New methods of resolution and purification of racemic and diastereomeric amino alcohol derivatives using boric acid and chiral 1,1'-bi-2-naphthol.
Resolution of the racemic amino alcohol derivatives 1-6 is readily achieved to obtain enantiomerically enriched compounds using chiral 1,1'-bi-2-naphthol and boric acid in solvents such as CH(3)CN, THF, and MeOH. Purification of the diastereomeric mixture 7 has also been carried out following this method. The corresponding intermediate ammonium borate complexes were also characterized by X-ray diffraction methods.
Periasamy
M
M
School of Chemistry, University of Hyderabad, Central University P.O., Hyderabad 500 046, India. mpsc@uohyd.ernet.in
Kumar
N S
NS
Sivakumar
S
S
Rao
V D
VD
Ramanathan
C R
CR
Venkatraman
L
L