Two novel and potent 3-[(o-methoxyphenyl)piperazinylethyl]-5-phenylthien.
The synthesis and in vitro characterization of A-119637 and A-123189, two novel, selective and potent alpha1D antagonists, are described.
Carroll
W A
WA
Abbott Laboratories, Neurological and Urological Diseases Research, Abbott Park, IL 60064-6101, USA. william.a.carroll@abbott.com
Sippy
K B
KB
Esbenshade
T A
TA
Buckner
S A
SA
Hancock
A A
AA
Meyer
M D
MD
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D002417:Cattle; D003001:Cloning, Molecular; D006801:Humans; D066298:In Vitro Techniques; D008024:Ligands; D008297:Male; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology*; D019275:Radiopharmaceuticals; D051381:Rats; D013154:Spleen / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
C436344:A119637; C436343:A123189; D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D008024:Ligands; D010879:Piperazines; D011743:Pyrimidines; D019275:Radiopharmaceuticals