[Synthesis and properties of O- and S-glycosylated derivatives of pyropheophorbide a].
New O- and S-glycosylated derivatives of pyropheophorbide a were synthesized in the context of the design of photosensitizers for photodynamic cancer therapy. The resulting amphiphilic conjugates were found to be sufficiently water-soluble and suitable for the study of the photosensitizer penetration and accumulation in tumors.
Aksenova
A A
AA
Lomonosov State Academy of Fine Chemical Technology, pr. Vernadskogo 86, Moscow, 117571 Russia.
Sebiakin
Iu L
IuL
Mironov
A F
AF
D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000737:chemistry*; D006031:Glycosylation; D009682:Magnetic Resonance Spectroscopy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry; D013053:Spectrophotometry
D017319:Photosensitizing Agents; D002734:Chlorophyll; C040298:pyropheophorbide a