title: Computational analysis of human disease-associated genes and their protein products.
abstract: The complete genome sequences for human, Drosophila melanogaster and Arabidopsis thaliana have been reported recently. With the availability of complete sequences for many bacteria and archaea, and five eukaryotes, comparative genomics and sequence analysis are enabling us to identify counterparts of many human disease genes in model organisms, which in turn should accelerate the pace of research and drug development to combat human diseases. Continuous improvement of specialized protein databases, together with sensitive computational tools, have enhanced the power and reliability of computational prediction of protein function.
authors.affiliation: National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, Maryland 20894, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Sreekumar
authors.forename: L
authors.initials: L
authors.lastname: Aravind
authors.forename: E V
authors.initials: EV
authors.lastname: Koonin
mesh_terms: D000818:Animals; D019295:Computational Biology / Q000379:methods*; D001330:Electronic Data Processing; D005544:Forecasting; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D009154:Mutation; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000032:analysis*; D017422:Sequence Analysis, DNA
chemical_list: D011506:Proteins