Hepatic decompensation associated with lamivudine: a case report and review of lamivudine-induced hepatotoxicity.
We report a case of a 62-yr-old man with chronic hepatitis B virus (HBV)-related cirrhosis who developed hepatic decompensation after being started on lamivudine requiring liver transplantation. Decompensated liver disease while on lamivudine has been previously reported on two occasions, both HIV coinfected patients on a combination of nucleoside analogues. Our patient is alive and well nearly 2 yr after successful liver transplantation.
Ormseth
E J
EJ
Department of Medicine, Walter Reed Army Medical Center, Washington, DC 20307, USA.
Holtzmuller
K C
KC
Goodman
Z D
ZD
Colonna
J O
JO
Batty
D S
DS
Sjogren
M H
MH
D019694:Hepatitis B, Chronic / Q000188:drug therapy; D006801:Humans; D019259:Lamivudine / Q000009:adverse effects* / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D017093:Liver Failure / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D018894:Reverse Transcriptase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
D018894:Reverse Transcriptase Inhibitors; D019259:Lamivudine