title: Continued neurogenesis is not a pre-requisite for regeneration of a topographic retino-tectal projection.
abstract: Electrophysiological recording demonstrated that visuo-tectal projections are topographically organised after optic nerve regeneration in aged Xenopus laevis. 3H-thymidine autoradiography confirmed previous reports [Taylor, Lack, & Easter, Eur. Journal of Neuroscience 1 (1989) 626-638] that cell division had already ceased at the retinal ciliary margin. The results demonstrate that, contrary to a previous suggestion [Holder & Clarke, Trends in Neuroscience 11 (1988) 94-99], continued neurogenesis is not a pre-requisite for the re-establishment of appropriate connections with target cells.
authors.affiliation: Department of Zoology, The University of Western Australia, Western Australia 6907, Nedlands, Australia.
authors.forename: R S
authors.initials: RS
authors.lastname: Beaver
authors.forename: S A
authors.initials: SA
authors.lastname: Dunlop
authors.forename: A M
authors.initials: AM
authors.lastname: Harman
authors.forename: R V
authors.initials: RV
authors.lastname: Stirling
authors.forename: S S
authors.initials: SS
authors.lastname: Easter
authors.forename: J D
authors.initials: JD
authors.lastname: Roberts
authors.forename: L D
authors.initials: LD
authors.lastname: Beazley
mesh_terms: D000375:Aging / Q000502:physiology; D000818:Animals; D001345:Autoradiography; D019771:Axotomy; D002455:Cell Division / Q000502:physiology; D002923:Cilia / Q000502:physiology; D004594:Electrophysiology; D009416:Nerve Regeneration / Q000502:physiology*; D009900:Optic Nerve / Q000166:cytology / Q000502:physiology*; D014982:Xenopus laevis