Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux.
Carnitine palmitoyltransferase I is assumed to be rate limiting for beta-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit beta-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for beta-oxidation in the heart.
Eaton
S
S
Unit of Paediatric Surgery, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, U.K. s.eaton@ich.ucl.ac.uk
Fukumoto
K
K
Paladio Duran
N
N
Pierro
A
A
Spitz
L
L
Quant
P A
PA
Bartlett
K
K
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002334:Carnitine O-Palmitoyltransferase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D008316:Malonyl Coenzyme A / Q000378:metabolism; D008929:Mitochondria, Heart / Q000201:enzymology / Q000378:metabolism; D009206:Myocardium / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism*; D010084:Oxidation-Reduction
D007527:Isoenzymes; D008316:Malonyl Coenzyme A; D000105:Acetyl Coenzyme A; D002334:Carnitine O-Palmitoyltransferase