Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists.
Elevated levels of the hormone resistin, which is secreted by fat cells, are proposed to cause insulin resistance and to serve as a link between obesity and type 2 diabetes. In this report we show that resistin expression is significantly decreased in the white adipose tissue of several different models of obesity including the ob/ob, db/db, tub/tub, and KKA(y) mice compared with their lean counterparts. Furthermore, in response to several different classes of antidiabetic peroxisome proliferator-activated receptor gamma agonists, adipose tissue resistin expression is increased in both ob/ob mice and Zucker diabetic fatty rats. These data demonstrate that experimental obesity in rodents is associated with severely defective resistin expression, and decreases in resistin expression are not required for the antidiabetic actions of peroxisome proliferator-activated receptor gamma agonists.
Way
J M
JM
GlaxoSmithKline Research and Development, Research Triangle Park, North Carolina 27709, USA.
Görgün
C Z
CZ
Tong
Q
Q
Uysal
K T
KT
Brown
K K
KK
Harrington
W W
WW
Oliver
W R
WR
Willson
T M
TM
Kliewer
S A
SA
Hotamisligil
G S
GS
D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D001577:Benzophenones / Q000494:pharmacology; D015536:Down-Regulation / Q000187:drug effects; D006729:Hormones, Ectopic / Q000096:biosynthesis*; D007004:Hypoglycemic Agents / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D051379:Mice; D020932:Nerve Growth Factor; D009765:Obesity / Q000378:metabolism*; D011506:Proteins; D051381:Rats; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists* / Q000378:metabolism; D052243:Resistin; D000077154:Rosiglitazone; D013844:Thiazoles / Q000494:pharmacology; D045162:Thiazolidinediones; D014157:Transcription Factors / Q000819:agonists* / Q000378:metabolism; D014443:Tyrosine / Q000031:analogs & derivatives / Q000494:pharmacology
D001577:Benzophenones; D006729:Hormones, Ectopic; D007004:Hypoglycemic Agents; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D052243:Resistin; C499623:Retn protein, mouse; C499622:Retn protein, rat; C413576:Retnla protein, mouse; C486575:Retnla protein, rat; D013844:Thiazoles; D045162:Thiazolidinediones; D014157:Transcription Factors; D000077154:Rosiglitazone; D014443:Tyrosine; D020932:Nerve Growth Factor; C120099:GW 1929