The effect of quercetin on apoptosis and necrosis induction in human colon adenocarcinoma cell line LS180.
Quercetin is a very common flavonoid widely distributed in many plants. The flavonoid intake has been linked to the prevention of some human diseases including cancer. Quercetin inhibits heat shock protein expression and in this way triggers apoptosis of tumor cells. The present study was designed to investigate whether quercetin exerts cytotoxic activity against human colon adenocarcinoma cells. The studies have shown that quercetin alone and in combination with the heat shock can induce apoptosis and necrosis in vitro in human colon adenocarcinoma cells (LS 180). Relationships between heat shock proteins and quercetin in this phenomenon are discussed.
Pawlikowska-Pawlega
B
B
Department of Comparative Anatomy and Anthropology, Maria Curie-Skłodowska University, Lublin, Poland. Pawbo@biotop.umcs.lublin.pl
Jakubowicz-Gil
J
J
Rzymowska
J
J
Gawron
A
A
D000230:Adenocarcinoma / Q000473:pathology*; D017209:Apoptosis / Q000187:drug effects*; D015153:Blotting, Western; D003110:Colonic Neoplasms / Q000473:pathology*; D004591:Electrophoresis, Polyacrylamide Gel; D006360:Heat-Shock Proteins / Q000378:metabolism; D006801:Humans; D009336:Necrosis; D011794:Quercetin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D006360:Heat-Shock Proteins; D011794:Quercetin