Proton MR spectroscopy in multiple sclerosis.
Axonal injury in multiple sclerosis (MS) is focal and diffuse, and is directly responsible for irreversible disability. Acute inflammatory events can be associated with reversible disability that may parallel reversible axonal injury. This in part accounts for the remission following relapses early in the disease. By the time there is clinical disability, substantial axonal injury already has occurred. This provides a strong rationale for the early limitation of inflammation and its consequences.
Arnold
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DL
Department of Neurology and Neurosurgery, McGill University, Montreal, Quebec, Canada H3A 2B4.
De Stefano
N
N
Narayanan
S
S
Matthews
P M
PM
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D002794:Choline / Q000378:metabolism; D003401:Creatine / Q000378:metabolism; D004185:Disability Evaluation; D018450:Disease Progression; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D012183:Retrograde Degeneration / Q000175:diagnosis / Q000503:physiopathology
D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline