title: [Involvement of the IGF system in the pathogenesis of adrenocortical tumors].
abstract: Adrenocortical carcinoma remains a challenge for the therapeutist; prognosis is ominous. Various abnormalities playing a pathogenetic role have been recently described in adrenocortical tumors. Among them, dysregulation of the IGF system and imprinting mistakes at the 11p15 locus play a determining role in malignant transformation of adrenocortical cells. These markers of the malignant phenotype might markedly improve our diagnosis and prognosis abilities.
authors.affiliation: Laboratoire d'Explorations Fonctionnelles Endocriniennes, Hôpital Trousseau, 75012 Paris.
authors.forename: C
authors.initials: C
authors.lastname: Gicquel
authors.forename: N
authors.initials: N
authors.lastname: Boulle
authors.forename: A
authors.initials: A
authors.lastname: Logié
authors.forename: N
authors.initials: N
authors.lastname: Bourcigaux
authors.forename: V
authors.initials: V
authors.lastname: Gaston
authors.forename: Y
authors.initials: Y
authors.lastname: Le Bouc
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000235:genetics; D002880:Chromosomes, Human, Pair 11; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000235:genetics; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D009154:Mutation; D013002:Somatomedins / Q000235:genetics* / Q000502:physiology
chemical_list: D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II