title: Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1.
abstract: The discovery of a series of phenylalanine derived CCR3 antagonists is reported. Parallel, solution-phase library synthesis has been utilized to delineate the structure-activity relationship leading to the synthesis of highly potent, CCR3-selective antagonists.
authors.affiliation: SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426-0989, USA. dash_dhanak-1@sbphrd.com
authors.forename: D
authors.initials: D
authors.lastname: Dhanak
authors.forename: L T
authors.initials: LT
authors.lastname: Christmann
authors.forename: M G
authors.initials: MG
authors.lastname: Darcy
authors.forename: A J
authors.initials: AJ
authors.lastname: Jurewicz
authors.forename: R M
authors.initials: RM
authors.lastname: Keenan
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: H M
authors.initials: HM
authors.lastname: Sarau
authors.forename: K L
authors.initials: KL
authors.lastname: Widdowson
authors.forename: J R
authors.initials: JR
authors.lastname: White
mesh_terms: D006801:Humans; D010649:Phenylalanine / Q000737:chemistry* / Q000494:pharmacology*; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: C515350:CCR3 protein, human; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; D010649:Phenylalanine