title: T1 hypointensities and axonal loss.
abstract: T1 hypointensities are lesions that are hypointense on moderately T1-weighted conventional spin-echo sequences and serve as markers of matrix destruction and axonal loss. They correlate better with clinical disability than T2-weighted images, are found in patients with progressive multiple sclerosis, and can be used as surrogate outcome measures in treatment trials.
authors.affiliation: Department of Radiology, Multiple Sclerosis MRI Research Centre Amsterdam, Vrije Universiteit Hospital, 1007 MB Amsterdam, The Netherlands. F.Barkhof@AZVU.NL
authors.forename: F
authors.initials: F
authors.lastname: Barkhof
authors.forename: G B
authors.initials: GB
authors.lastname: Karas
authors.forename: M A
authors.initials: MA
authors.lastname: van Walderveen
mesh_terms: D001369:Axons / Q000473:pathology; D001921:Brain / Q000473:pathology; D003937:Diagnosis, Differential; D004185:Disability Evaluation; D017352:Echo-Planar Imaging; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009103:Multiple Sclerosis / Q000175:diagnosis* / Q000473:pathology; D020528:Multiple Sclerosis, Chronic Progressive / Q000175:diagnosis / Q000473:pathology; D012183:Retrograde Degeneration / Q000175:diagnosis* / Q000473:pathology