title: Cell contact dependent extended release of adenovirus by microparticles in vitro.
abstract: Adenoviral vectors remain one of the most promising methods of gene delivery but are plagued by several inherent problems including immune inactivation and transient expression. This paper reports a novel microparticle-based delivery system for adenovirus that allows high uptake of virus, stable complex formation and extended release. In addition, this microparticle/adenovirus complex has been demonstrated to only release virus upon cell contact. The significant clinical implications of this delivery system are discussed.
authors.affiliation: School of Biomedical Sciences, Charles Sturt University, Locked Bag 588, NSW 2678, Wagga Wagga, Australia. hcavanagh@csu.edu.au
authors.forename: H M
authors.initials: HM
authors.lastname: Cavanagh
authors.forename: D
authors.initials: D
authors.lastname: Dingwall
authors.forename: J
authors.initials: J
authors.lastname: Steel
authors.forename: J
authors.initials: J
authors.lastname: Benson
authors.forename: M
authors.initials: M
authors.lastname: Burton
mesh_terms: D000260:Adenoviruses, Human / Q000276:immunology / Q000502:physiology*; D002460:Cell Line; D006801:Humans; D014407:Tumor Cells, Cultured