Properties and modulation of mammalian 2P domain K+ channels.
Mammalian 2P domain K(+) channels are responsible for background or 'leak' K(+) currents. These channels are regulated by various physical and chemical stimuli, including membrane stretch, temperature, acidosis, lipids and inhalational anaesthetics. Furthermore, channel activity is tightly controlled by membrane receptor stimulation and second messenger phosphorylation pathways. Several members of this novel family of K(+) channels are highly expressed in the central and peripheral nervous systems in which they are proposed to play an important physiological role. The pharmacological modulation of this novel class of ion channels could be of interest for both general anaesthesia and ischaemic neuroprotection.
Patel
A J
AJ
Institut de Pharmacologie Moléculaire et Cellulaire, CNRS-UMR6097, 660 route des Lucioles, Sophia Antipolis, 06560, Valbonne, France.
Honoré
E
E
D000138:Acidosis / Q000503:physiopathology; D018681:Anesthetics, General / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003080:Cold Temperature; D006358:Hot Temperature; D006801:Humans; D008563:Membrane Lipids / Q000494:pharmacology / Q000502:physiology; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D024683:Potassium Channels, Tandem Pore Domain
D018681:Anesthetics, General; C503438:KCNK10 protein, human; C503432:KCNK4 protein, human; D008563:Membrane Lipids; D015221:Potassium Channels; D024683:Potassium Channels, Tandem Pore Domain; C103742:potassium channel protein TREK-1