title: Dearomatizing anionic cyclizations of N-benzyl-N-methyldiphenylphosphinamides. Synthesis of gamma-(N-methylamino)phosphinic acids.
abstract: The first dearomatizing anionic reaction of a phenyl ring promoted by an N-benzyl-N-methylphosphinamide group is described. The intermediate lithium species can be trapped with different electrophiles, affording tetrahydrobenzo[c]-1-aza-2lambda(5)-phospholes with excellent diastereoselectivity. The new process is a simple and very efficient entry to the stereoselective synthesis of functionalized gamma-(N-methylamino)phosphinic acids and esters.
authors.affiliation: Area de Química Orgánica, Universidad de Almería, Carretera de Sacramento s/n, 04120 Almería, Spain.
authors.forename: I
authors.initials: I
authors.lastname: Fernández
authors.forename: F L
authors.initials: FL
authors.lastname: Ortiz
authors.forename: B
authors.initials: B
authors.lastname: Tejerina
authors.forename: S G
authors.initials: SG
authors.lastname: Granda