title: [The mechanism on hyperpolarization of membrane potential induced by adenosine in frog melanotrophs].
abstract: It has been previously shown that the activation of A1 adenosine receptors in frog melanotroph induced a hyperpolarization accompanied by blockage of spontaneous action potentials. In the present report, we explored mechanisms underlying the above phenomenon using the patch-clamp technique in whole-cell and cell-attached configuration. The result showed that adenosine could increase the opening of non-voltage-activated potassium channels leading to hyperpolarization, but an inward cation current activated by hyperpolarizing pulse was not involved.
authors.affiliation: Department of Physiology and Biophysics, Li Ren Laboratory, Fudan University, Shanghai 200433.
authors.forename: Y A
authors.initials: YA
authors.lastname: Mei
authors.forename: H
authors.initials: H
authors.lastname: Vaudry
authors.forename: L
authors.initials: L
authors.lastname: Cazin
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D008297:Male; D009074:Melanocyte-Stimulating Hormones / Q000378:metabolism / Q000502:physiology*; D008564:Membrane Potentials; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000187:drug effects*; D011898:Ranidae; D018047:Receptors, Purinergic P1 / Q000378:metabolism
chemical_list: D015221:Potassium Channels; D018047:Receptors, Purinergic P1; D009074:Melanocyte-Stimulating Hormones; D000241:Adenosine