Enteric viruses associated with HIV infection in Tanzanian children with chronic diarrhea.
OBJECTIVE
To determine whether specific viruses are associated with HIV infection in Tanzanian children with chronic diarrhea.


METHODS
Cross-sectional survey.


METHODS
Major national teaching hospital in Dar es Salaam, Tanzania.


METHODS
Consecutively admitted, human immunodeficiency virus (HIV)-infected and HIV-uninfected children with chronic diarrhea, and controls without diarrhea, aged 15 months to 5 years.


METHODS
Enteric viruses identified by electron microscopy (EM) of fecal specimens.


RESULTS
Small round structured viruses (SRSV) were more frequent in HIV-infected than HIV-uninfected children with chronic diarrhea (4 of 21 vs 1 of 32, prevalence ratio = 6.09, 90% confidence limits 1.03, 36.14). Rotavirus and coronavirus-like particles (CVLP) were not associated with HIV infection.


CONCLUSIONS
SRSV may be associated with HIV infection in Tanzanian children with chronic diarrhea. Larger, confirmatory studies are needed.
Cegielski
J P
JP
Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Msengi
A E
AE
Miller
S E
SE
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000821:virology*; D002908:Chronic Disease; D017934:Coronavirus / Q000302:isolation & purification; D003430:Cross-Sectional Studies; D003967:Diarrhea / Q000150:complications* / Q000821:virology; D005243:Feces / Q000382:microbiology; D005759:Gastroenteritis / Q000150:complications / Q000821:virology; D006801:Humans; D009663:Norwalk virus / Q000302:isolation & purification; D012401:Rotavirus / Q000302:isolation & purification; D013636:Tanzania; D014777:Virus Diseases / Q000150:complications*