title: Progressive brain atrophy on serial MRI in dementia with Lewy bodies, AD, and vascular dementia.
abstract: The authors determined rates of brain atrophy, as assessed by the boundary shift integral on serial MRI, in patients with dementia with Lewy Bodies (DLB, n = 10), AD (n = 9), vascular dementia (VaD, n = 9), and age-matched controls (n = 20). Mean % +/- SD atrophy rates per year were as follows: DLB, 1.4 +/- 1.1; AD, 2.0 +/- 0.9; VaD, 1.9 +/- 1.1; and controls, 0.5 +/- 0.7. Dementia subjects had higher rates than controls (p < 0.001), but there were no significant differences between the three dementia groups. The authors found accelerating atrophy with increasing severity of cognitive impairment, further emphasizing the need for early diagnosis and intervention in dementia.
authors.affiliation: Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, United Kingdom. j.t.o'brien@ncl.ac.uk
authors.forename: J T
authors.initials: JT
authors.lastname: O'Brien
authors.forename: S
authors.initials: S
authors.lastname: Paling
authors.forename: R
authors.initials: R
authors.lastname: Barber
authors.forename: E D
authors.initials: ED
authors.lastname: Williams
authors.forename: C
authors.initials: C
authors.lastname: Ballard
authors.forename: I G
authors.initials: IG
authors.lastname: McKeith
authors.forename: A
authors.initials: A
authors.lastname: Gholkar
authors.forename: W R
authors.initials: WR
authors.lastname: Crum
authors.forename: M N
authors.initials: MN
authors.lastname: Rossor
authors.forename: N C
authors.initials: NC
authors.lastname: Fox
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology; D001284:Atrophy / Q000473:pathology / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D015140:Dementia, Vascular / Q000473:pathology* / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D020961:Lewy Body Disease / Q000473:pathology* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male