Nuclear lipid signaling: novel role of eicosanoids.
Nuclear lipid signaling is an established, widespread mechanism that operates in multiple cellular processes including proliferative and differentiative responses to a variety of stimuli. In this literature review with key references highlighted, we put forward the hypothesis that differential flow through various intracrine mechanisms can dictate resultant cellular actions such as mitosis, differentiation, or apoptosis.
Gilmour
R S
RS
Liggins Institute and Department of Pharmacology & Clinical Pharmacology, University of Auckland, Faculty of Medical and Health Sciences, New Zealand.
Mitchell
M D
MD
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D015777:Eicosanoids / Q000378:metabolism*; D020404:Glycerophospholipids / Q000378:metabolism*; D006801:Humans; D008938:Mitosis; D011453:Prostaglandins / Q000378:metabolism; D015290:Second Messenger Systems; D015398:Signal Transduction
D001095:Arachidonic Acids; D015777:Eicosanoids; D020404:Glycerophospholipids; D011453:Prostaglandins