Acquired Factor VIII autoantibody: four cases demonstrating the heterogenous nature of this condition and problems involved in diagnosis and treatment.
The development of an autoantibody to human Factor VIII is rare and presents many problems for diagnosis and treatment. We have seen several cases at our institution recently with widely heterogenous clinical and laboratory presentations. A wide range of treatment modalities were used in these cases with no gold standard of treatment or widely accepted guidelines existing. This has prompted us to examine all cases of this condition presenting at Fremantle Hospital over the last decade. We describe four cases which demonstrate the heterogeneity of this condition and its treatment and review the recent literature on the subject.
Hall
R L
RL
Department of Haematology, Fremantle Hospital, Alma Street, Fremantle, WA 6160, Australia.
Leahy
M F
MF
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001172:Arthritis, Rheumatoid / Q000150:complications; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D001379:Azathioprine / Q000627:therapeutic use; D001943:Breast Neoplasms; D002317:Cardiovascular Agents / Q000627:therapeutic use; D002318:Cardiovascular Diseases / Q000150:complications / Q000188:drug therapy; D002699:Chlorambucil / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005169:Factor VIII / Q000276:immunology* / Q000627:therapeutic use; D005260:Female; D006406:Hematoma / Q000209:etiology; D006467:Hemophilia A / Q000175:diagnosis / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007239:Infections / Q000209:etiology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications / Q000188:drug therapy; D008297:Male; D009378:Neoplasms, Multiple Primary; D010314:Partial Thromboplastin Time; D011239:Prednisolone / Q000627:therapeutic use; D012189:Retrospective Studies
D001323:Autoantibodies; D002317:Cardiovascular Agents; D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D002699:Chlorambucil; D003520:Cyclophosphamide; D005169:Factor VIII; D011239:Prednisolone; D001379:Azathioprine