title: Two new constituents of Isodon excisus and their evaluation in an apoptosis inhibition assay.
abstract: Investigation of the whole plant of Isodon excisus resulted in the isolation of two new apoptosis inhibitors (1 and 2). Compounds 1 and 2 inhibited etoposide-induced apoptosis in U937 cells with IC50 values of 10.2 and 52.4 microg/mL, respectively. The structures of 1 and 2 were determined by spectral data interpretation.
authors.affiliation: Korea Research Institute of Bioscience and Biotechnology (KRIBB), P.O. Box 115, Yusong, Taejon 305-600, Korea.
authors.forename: C
authors.initials: C
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Kim
authors.forename: H
authors.initials: H
authors.lastname: Lee
authors.forename: S
authors.initials: S
authors.lastname: Lee
authors.forename: Y
authors.initials: Y
authors.lastname: Kho
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000037:antagonists & inhibitors / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects*; D020169:Caspases / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D005047:Etoposide / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D007723:Korea; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D020298:U937 Cells
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D005047:Etoposide; D020169:Caspases