title: A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia.
abstract: The 5HT2C receptor has a high affinity for clozapine, a nontypical neuroleptic, and has therefore been postulated to play a role in mediating negative symptoms and neuroleptic response in schizophrenia. In the current study, the Cys23Ser 5HT2C serotonin receptor polymorphism was examined for linkage to schizophrenia by genotyping 207 nuclear families consisting of both parents and schizophrenic child and using the transmission disequilibrium test to examine possible preferential transmission of these alleles from 68 heterozygous mothers to their ill child. No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS).
authors.affiliation: Dr. Kemal Psychiatric Hospital, Bethlehem, Palestine.
authors.forename: I
authors.initials: I
authors.lastname: Murad
authors.forename: I
authors.initials: I
authors.lastname: Kremer
authors.forename: M
authors.initials: M
authors.lastname: Dobrusin
authors.forename: M
authors.initials: M
authors.lastname: Muhaheed
authors.forename: I
authors.initials: I
authors.lastname: Bannoura
authors.forename: D J
authors.initials: DJ
authors.lastname: Müller
authors.forename: T G
authors.initials: TG
authors.lastname: Schulze
authors.forename: A
authors.initials: A
authors.lastname: Reshef
authors.forename: M
authors.initials: M
authors.lastname: Blanaru
authors.forename: S
authors.initials: S
authors.lastname: Gathas
authors.forename: V
authors.initials: V
authors.lastname: Tsenter
authors.forename: M
authors.initials: M
authors.lastname: Rietschel
authors.forename: R H
authors.initials: RH
authors.lastname: Belmaker
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: R P
authors.initials: RP
authors.lastname: Ebstein
mesh_terms: D000293:Adolescent; D000328:Adult; D019943:Amino Acid Substitution; D018912:Arabs / Q000235:genetics; D005192:Family Health; D005260:Female; D005820:Genetic Testing; D005858:Germany; D006579:Heterozygote; D006801:Humans; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D008875:Middle Aged; D009035:Mothers; D009679:Nuclear Family; D011110:Polymorphism, Genetic; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000235:genetics*; D012559:Schizophrenia / Q000208:ethnology / Q000209:etiology / Q000235:genetics*; D044465:White People / Q000235:genetics
chemical_list: D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin