title: Inhibition of immunologic and nonimmunologic stimulation-mediated anaphylactic reactions by water extract of white eggplant (Solanum melongena).
abstract: We investigated the effect of water extract of Solanum melongena(SMWE) on immunologic and nonimmunologic stimulation-mediated anaphylactic reactions. Nonimmunologic anaphylactic reaction was induced by compound 48/80 injection. Oral administration of SMWE (1 g kg(-1)) completely inhibited compound 48/80-induced anaphylactic reaction. Immunologic anaphylactic reaction was generated by sensitizing the skin with anti-dinitrophenyl (DNP) IgE followed 48 h later with an injection of antigen. Oral administration of SMWE (0.01--1 g kg(-1)) significantly inhibited passive cutaneous anaphylactic reaction activated by anti-DNP IgE to between 83.10 +/- 1.67% and 70.17 +/- 2.17%. SMWE (0.01--1 mg ml(-1)) also inhibited histamine release activated by compound 48/80 to between 93 +/- 2.65 and 70 +/- 1.50%. Moreover, SMWE (0.01--1 mg ml(-1)) had a significant inhibitory effect on IgE-induced tumor necrosis factor (TNF)-alpha secretion from rat peritoneal mast cells. These results indicate that SMWE inhibits immunologic and nonimmunologic stimulation-mediated anaphylactic reactions and TNF-alpha secretion from mast cells.
authors.affiliation: Department of Oriental Pharmacy, College of Pharmacy, Wonkwang University, Iksan, Chonbuk, 570-749, Republic of Korea.
authors.forename: Y M
authors.initials: YM
authors.lastname: Lee
authors.forename: H J
authors.initials: HJ
authors.lastname: Jeong
authors.forename: H J
authors.initials: HJ
authors.lastname: Na
authors.forename: J Y
authors.initials: JY
authors.lastname: Ku
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: G
authors.initials: G
authors.lastname: Moon
authors.forename: H J
authors.initials: HJ
authors.lastname: Chae
authors.forename: H R
authors.initials: HR
authors.lastname: Kim
authors.forename: H M
authors.initials: HM
authors.lastname: Kim
mesh_terms: D000284:Administration, Oral; D000707:Anaphylaxis / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology*; D000818:Animals; D001685:Biological Factors / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D004140:Dinitrophenols / Q000276:immunology; D004195:Disease Models, Animal; D006632:Histamine / Q000378:metabolism; D007073:Immunoglobulin E / Q000276:immunology; D019684:Magnoliopsida / Q000737:chemistry*; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008813:Mice, Inbred ICR; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D003189:p-Methoxy-N-methylphenethylamine / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: D001685:Biological Factors; D004140:Dinitrophenols; D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine