LH pulses and the corpus luteum: the luteal phase deficiency LPD).
The proper function of the GnRH pulse generator in the hypothalamus is essential for normal ovarian function, hence also for proper function of the corpus luteum. During the luteal phase LH pulses stimulate progesterone release, which is essential for normal endometrial transformation. Approximately one-half of all luteal phase deficiencies (LPD) are due to improper function of the GnRH pulse generator. Obviously, following ovulation the increased serum progesterone levels oversuppress the GnRH pulse generator, resulting in too few LH pulses and therefore improper luteal function. Also, latent hyperprolactinemia may lead to an LPD which can be effectively treated with plant extracts containing dopaminergic (prolactin-suppressing) compounds. Our increasing knowledge of auto- and paracrine mechanisms between nonsteroidogenic and steroidogenic cells now allow subclassification of LPDs of ovarian origin. The so-called small luteal cells are LH-responsive. If they develop improperly the regularly occurring LH pulses are unable to stimulate progesterone secretion from the small luteal cells, which results in what we call the small luteal cell defect. In addition, there is also evidence that the large luteal cells may function improperly. Hence, basal progesterone release is too low while LH-stimulated progesterone release from the small luteal cells appears to be intact. This subclassification of luteal phase deficiency results in the suggestion of different treatments. In cases where the corpus luteum is LH-responsive, such as the hypothalamic corpus luteum insufficiency and the large luteal cell defect, HCG treatment or pulsatile treatment with GnRH is advisable. In the case of LH/hCG-unresponsive small luteal cell defect a progesterone substitution is suggested.
Wuttke
W
W
Department of Obstetrics and Gynecology, University of Göttingen, Germany.
Pitzel
L
L
Seidlová-Wuttke
D
D
Hinney
B
B
D000818:Animals; D003338:Corpus Luteum / Q000378:metabolism* / Q000502:physiology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000209:etiology*; D008183:Luteal Phase / Q000502:physiology*; D007986:Luteinizing Hormone / Q000378:metabolism*; D011374:Progesterone / Q000097:blood
D011374:Progesterone; D007986:Luteinizing Hormone