Glycosidase inhibitors of gem-diamine 1-N-iminosugars. structures in media of enzyme assays.
The relationships between structures and inhibitory activities of glycosidase inhibitors of gem-diamine 1-N-iminosugars in media of enzyme assays have been investigated. It has been proved that gem-diamine 1-N-iminosugar smoothly undergoes a structural change to a hydrated ketone or its derivative via a hemiaminal in the media (pH 5.0-6.3), and that the products generated in the media as well as the parent gem-diamine 1-N-iminosugars potently inhibit glycosidases.
Kondo
K I
KI
Institute of Microbial Chemistry, 3-14-23 Kamiosaki, Shinagawa-ku, Tokyo 141-0021, Japan.
Adachi
H
H
Shitara
E
E
Kojima
F
F
Nishimura
Y
Y
D000818:Animals; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry / Q000494:pharmacology; D003959:Diamines / Q000737:chemistry; D004791:Enzyme Inhibitors / Q000378:metabolism* / Q000494:pharmacology; D006026:Glycoside Hydrolases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007097:Imines / Q000737:chemistry; D007659:Ketones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013997:Time Factors; D005644:alpha-L-Fucosidase / Q000037:antagonists & inhibitors / Q000378:metabolism*
D002241:Carbohydrates; D003959:Diamines; D004791:Enzyme Inhibitors; D007097:Imines; D007659:Ketones; D006026:Glycoside Hydrolases; D005644:alpha-L-Fucosidase