The influence of L-arginine on heart rate and tissue oxygen extraction in haemorrhaged rabbits.
Several studies have already indicated some beneficial effects of L-arginine in haemorrhaged rats. The aim of our study was to assess whether intravenous bolus injection of L-arginine could improve some cardiovascular and metabolic parameters in anaesthetized haemorrhaged rabbits (intermittent bleeding; 40% of the estimated blood volume for 15 min). I.v. bolus injection of L-arginine ( 300 mg kg(-1)--L-Arg(300)) increased heart rate (app. 10%) and decreased venous haemoglobin saturation with oxygen (sO(2)) (app. 23%) 60 min after the cessation of bleeding, without changes in arterial pressure. D-arginine (300 mg kg(-1)i.v. bolus-D-Arg(300)) produced similar, but insignificant haemodynamic and metabolic changes. In addition, no difference was found between the effects of the L- and D-isomers. Accordingly, L-arginine produces beneficial effects on the heart rate and tissue oxygen extraction in haemorrhaged rabbits. However, such changes do not appear to be stereospecific.
Todorović
Z
Z
Department of Clinical Pharmacology, Pharmacology and Toxicology, School of Medicine, PO Box 840, 11000 Belgrade, Yugoslavia.
Prostran
M
M
Vucković
S
S
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000818:Animals; D001120:Arginine / Q000008:administration & dosage / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D001798:Blood Proteins / Q000032:analysis; D006339:Heart Rate / Q000187:drug effects*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006470:Hemorrhage / Q000188:drug therapy / Q000378:metabolism*; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000378:metabolism*; D011817:Rabbits; D013237:Stereoisomerism; D015996:Survival Rate; D014882:Water-Electrolyte Balance / Q000187:drug effects
D001798:Blood Proteins; D006454:Hemoglobins; D001120:Arginine; D010100:Oxygen