Human disease: calcium signaling in polycystic kidney disease.
Polycystic kidney disease results from loss of function of either of two novel proteins, polycystin-1 or polycystin-2. Recent studies show that intracellular calcium signaling is important in kidney development, and define defects in this signaling pathway as the basis of cyst formation in polycystic kidney disease.
Somlo
S
S
Department of Internal Medicine, Yale University School of Medicine, Connecticut, New Haven, USA. stefan.somlo@yale.edu
Ehrlich
B
B
D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D020013:Calcium Signaling; D006801:Humans; D008565:Membrane Proteins / Q000502:physiology; D007690:Polycystic Kidney Diseases / Q000378:metabolism*; D011506:Proteins / Q000502:physiology; D050396:TRPP Cation Channels
D015220:Calcium Channels; D008565:Membrane Proteins; D011506:Proteins; D050396:TRPP Cation Channels