A new Antennapedia-derived vector for intracellular delivery of exogenous compounds.
We describe the design, synthesis and cell translocation capacity of a peptide derived from the third alpha-helix of the homeodomain of Antennapedia. The new sequence appears to be an efficient and nontoxic means to deliver a covalently linked peptide cargo into cells.
García-Echeverría
C
C
Oncology Research, Novartis Pharma Inc., CH-4002, Basel, Switzerland. carlos.garcia-echeverria@pharma.novartis.com
Jiang
L
L
Ramsey
T M
TM
Sharma
S K
SK
Chen
Y P
YP
D051943:Antennapedia Homeodomain Protein; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015195:Drug Design; D018398:Homeodomain Proteins / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D014157:Transcription Factors; D014407:Tumor Cells, Cultured
D051943:Antennapedia Homeodomain Protein; D004337:Drug Carriers; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D010455:Peptides; D014157:Transcription Factors