title: Carnitine palmitoyl transferase I and the control of myocardial beta-oxidation flux.
abstract: Carnitine palmitoyltransferase I is assumed to be rate limiting for beta-oxidation in all tissues. However, the concentration of malonyl-CoA in heart and muscle is high and is enough to completely inhibit beta-oxidation if this assumption is correct. In this review, we consider whether: (i) there is a malonyl-CoA-insensitive carnitine palmitoyltransferase I activity; (ii) the measured malonyl-CoA concentration in the heart is physiologically meaningful; and (iii) carnitine palmitoyltransferase I is rate-limiting for beta-oxidation in the heart.
authors.affiliation: Unit of Paediatric Surgery, Institute of Child Health, 30 Guilford Street, London WC1N 1EH, U.K. s.eaton@ich.ucl.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Eaton
authors.forename: K
authors.initials: K
authors.lastname: Fukumoto
authors.forename: N
authors.initials: N
authors.lastname: Paladio Duran
authors.forename: A
authors.initials: A
authors.lastname: Pierro
authors.forename: L
authors.initials: L
authors.lastname: Spitz
authors.forename: P A
authors.initials: PA
authors.lastname: Quant
authors.forename: K
authors.initials: K
authors.lastname: Bartlett
mesh_terms: D000105:Acetyl Coenzyme A / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002334:Carnitine O-Palmitoyltransferase / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D008316:Malonyl Coenzyme A / Q000378:metabolism; D008929:Mitochondria, Heart / Q000201:enzymology / Q000378:metabolism; D009206:Myocardium / Q000166:cytology / Q000201:enzymology* / Q000378:metabolism*; D010084:Oxidation-Reduction
chemical_list: D007527:Isoenzymes; D008316:Malonyl Coenzyme A; D000105:Acetyl Coenzyme A; D002334:Carnitine O-Palmitoyltransferase