title: Bone mineral content and bone metabolism in young adults with severe periodontitis.
abstract: OBJECTIVE
  To clarify in young adults with severe periodontitis (1) whether the bone mineral content (BMC) or density (BMD) in the mandible/other skeletal sites and the systemic bone metabolism differed from normal and (2) whether mandibular/forearm BMC did change during the 5 to 10-year follow-up.
  
  
  METHODS
  24 young otherwise normal patients with verified severe periodontitis were included, of which 20 attended the follow-up visit. Mandibular/forearm BMC was measured at both visits by dual-photon absorptiometry, supplemented with femoral neck/lumbar spine BMD measurements at follow-up visit by dual-energy X-ray absorptiometry. Serum alkaline phosphatase/ionized calcium, urinary excretion of pyridinoline/deoxy-pyridinoline were analysed at the follow-up visit. A conventional periodontal examination was performed at both visits.
  
  
  RESULTS
  Mandibular BMC was significantly below normal mean BMC at both visits. The mandibular Z-scores were < or = -2.00 in 33.3% (8/24). BMC/BMD in the remaining sites and the values for bone markers did not differ from normal. Mandibular/forearm BMC was stable while a significant aggravation of alveolar bone loss occurred during the trial without change of probing depth.
  
  
  CONCLUSIONS
  Severe periodontitis in young adults seems to be a local disorder associated with relatively low BMC in the jaws without systemic alterations of BMC/BMD and bone metabolism.
authors.affiliation: Department of Oral Maxillofacial Surgery, School of Dentistry, Faculty of Health Sciences, University of Copenhagen, Denmark.
authors.forename: N
authors.initials: N
authors.lastname: von Wowern
authors.forename: J
authors.initials: J
authors.lastname: Westergaard
authors.forename: G
authors.initials: G
authors.lastname: Kollerup
mesh_terms: D015502:Absorptiometry, Photon; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D016301:Alveolar Bone Loss / Q000378:metabolism / Q000503:physiopathology; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000652:urine; D015519:Bone Density / Q000502:physiology*; D001842:Bone and Bones / Q000378:metabolism* / Q000503:physiopathology; D002118:Calcium / Q000097:blood; D005260:Female; D005272:Femur Neck / Q000378:metabolism / Q000503:physiopathology; D005500:Follow-Up Studies; D005542:Forearm / Q000503:physiopathology; D006801:Humans; D008159:Lumbar Vertebrae / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008334:Mandible / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D008903:Minerals / Q000032:analysis; D010518:Periodontitis / Q000378:metabolism* / Q000503:physiopathology; D013223:Statistics as Topic
chemical_list: D000596:Amino Acids; D015415:Biomarkers; D008903:Minerals; C015484:pyridinoline; C036020:deoxypyridinoline; D000469:Alkaline Phosphatase; D002118:Calcium