title: Metabolic disturbance in obese children: glucose, insulin levels and lipid profile.
abstract: Obesity is a common nutritional disorder among children and adolescents. The purpose of this study was to investigate the biochemical changes in obese children in Taiwan, in comparison with those observed by other authors. Children with weights above 120 percent of ideal body weight were considered obese. Serum glucose, insulin, uric acid, and creatinine levels and lipid profiles of 298 obese children (mean age 11.3 +/- 2.4 years, 158 boys) and 60 controls (mean age 11.6 +/- 2.2 years, 38 boys) were determined using accepted procedures. Demographic and serum biochemical characteristics were compared between obese and control groups overall and by gender. Serum glucose, insulin, cholesterol, and triglyceride levels, known risk factors for coronary heart disease, were higher in the obese patients than in the control group. Early treatment and prevention of childhood obesity may keep the metabolic disturbance from deteriorating and becoming risk factors for coronary heart disease.
authors.affiliation: Department of Pediatrics, Mackay Memorial Hospital, 92, Sec. 2, Chung-San North Road, Taipei, 10449, Taiwan.
authors.forename: H K
authors.initials: HK
authors.lastname: Hwang
authors.forename: M R
authors.initials: MR
authors.lastname: Chen
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lee
authors.forename: H C
authors.initials: HC
authors.lastname: Lee
authors.forename: C Y
authors.initials: CY
authors.lastname: Huang
authors.forename: H A
authors.initials: HA
authors.lastname: Kao
authors.forename: F Y
authors.initials: FY
authors.lastname: Huang
authors.forename: B F
authors.initials: BF
authors.lastname: Shih
mesh_terms: D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis*; D002648:Child; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008055:Lipids / Q000097:blood*; D008297:Male; D009765:Obesity / Q000378:metabolism*; D012044:Regression Analysis
chemical_list: D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D007328:Insulin; D008055:Lipids