Does phosphoenolpyruvate carboxykinase have a role in both amino acid and carbohydrate metabolism?
Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation of oxaloacetate to yield phosphoenolpyruvate and CO2. The role of the enzyme in gluconeogenesis and anaplerotic reactions in a range of organisms is discussed, along with the important function in C4 and CAM photosynthesis in higher plants. In addition, new data are presented indicating that PEPCK may play a key role in amino acid metabolism. It is proposed that PEPCK is involved in the conversion of the carbon skeleton of asparagine/aspartate (oxaloacetate) to that of glutamate/glutamine (2-oxoglutarate). This metabolism is particularly important in the transport system, seeds and fruits of higher plants.
Lea
P J
PJ
Department of Biological Sciences, Lancaster University, United Kingdom.
Chen
Z H
ZH
Leegood
R C
RC
Walker
R P
RP
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001419:Bacteria / Q000378:metabolism; D050260:Carbohydrate Metabolism; D019764:Phosphoenolpyruvate Carboxykinase (ATP) / Q000378:metabolism*; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism; D010788:Photosynthesis; D010944:Plants / Q000378:metabolism; D012639:Seeds / Q000378:metabolism; D015003:Yeasts / Q000378:metabolism
D000596:Amino Acids; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D019764:Phosphoenolpyruvate Carboxykinase (ATP)