[Changes in levels of p53 protein, immunoglobulin L-chains, and iron complexes in mice of leukosis strain AKR following low dose irradiation].
Changes in the content of protein p53 (regulator of the cell cycle) L-chains of immunoglobulins, and iron complexes (Fe2+) during the development of spontaneous leukosis in AKR mice and upon irradiation of animals with a dose of 1.2 cGy were studied by ESR spectroscopy, electrophoresis, and immunoblotting. It was found that irradiation leads to an increase in the incidence of leukoses in males by 7% and a decrease in life duration of females. A decrease in the content of protein p53 and L-chains in immunoglobulins in males and females was observed; however, in females, the decreases was less pronounced because the content of these proteins in females is naturally decreased. In mice irradiated with low doses at the age of three- to four months, a decrease in the amount of iron complexes at a later age (seven- to eight months) was registered. These data suggest that there is a relationship between the induction of protein p53 and the content of immunoglobulin L-chains in the blood serum of animals.
Mil'
E M
EM
Emanuel Institute of Biochemical Physics, Russian Academy of Sciences, ul. Kosygina 4, Moscow GSP-1, 117977 Russia.
Kasparov
V V
VV
Borisova
O A
OA
Myshliakova
O V
OV
Erokhin
V N
VN
D000375:Aging; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D005260:Female; D005720:Gamma Rays; D007147:Immunoglobulin Light Chains / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D016159:Tumor Suppressor Protein p53 / Q000097:blood / Q000378:metabolism*
D001798:Blood Proteins; D007147:Immunoglobulin Light Chains; D016159:Tumor Suppressor Protein p53; D007501:Iron