Induction of alpha1-acid glycoprotein mRNA by cytokines and differentiation in human colon carcinoma cell.
The mRNA for the alpha1-acid glycoprotein (AAG) was expressed not only in hepatoma cells, but also in non-hepatic cancer cells. The expression of the AAG mRNA in HT-29 human colon carcinoma cells is induced by cytokines, IL-6, IL-1, and TNF-alpha, in a manner characteristic of the acute phase response, and the expression of AAG mRNA was up-regulated in differentiated HT-29 cells.
Lee
Y
Y
Department of Natural Sciences, College of Medicine, The Catholic University of Korea, Seoul. lsyng@cmc.cuk.ac.kr
Lim
J W
JW
Kim
Y M
YM
Lee
I H
IH
Choi
Y C
YC
Park
K C
KC
D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D016895:Culture Media, Serum-Free; D015972:Gene Expression Regulation, Neoplastic; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D009961:Orosomucoid / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D016895:Culture Media, Serum-Free; D007375:Interleukin-1; D015850:Interleukin-6; D009961:Orosomucoid; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha