Coordination of chemokine and adhesion systems in intratumoral T cell migration responsible for the induction of tumor regression.
T cell migration into tumor masses is critical to the process of immunologically induced tumor regression. Like other lymphoid populations, T cells are recruited to inflammatory sites depending on the interaction of T cell integrin receptors with their ligands expressed on vasculature. It is increasingly becoming evident that the adhesive capacity of integrins is upregulated by signals from chemokine receptors. A model of intratumoral T cell migration has been established using IL-12 to induce tumor regression. Focusing on this particular model, we review how IL-12 works to upregulate the expression and/or function of chemokines/chemokine receptors as well as adhesion molecules and to induce collaboration between chemokine and adhesion systems. This article will also describe why such an IL-12-induced activation of chemokine and adhesion systems leads to T cell-mediated tumor regression in some tumor models, but not in others.
Fujiwara
H
H
Department of Oncology, Biomedical Research Center, Osaka University Graduate School of Medicine 2-2, Japan.
Hamaoka
T
T
D000818:Animals; D000938:Antigen-Presenting Cells / Q000502:physiology; D002448:Cell Adhesion; D002465:Cell Movement; D006801:Humans; D039041:Integrin alpha4beta1; D016023:Integrins / Q000502:physiology; D018664:Interleukin-12 / Q000494:pharmacology*; D016169:Lymphocyte Function-Associated Antigen-1 / Q000502:physiology; D009369:Neoplasms / Q000276:immunology*; D019713:Receptors, CCR5 / Q000502:physiology; D018123:Receptors, Interleukin / Q000502:physiology*; D053707:Receptors, Interleukin-12; D016201:Receptors, Lymphocyte Homing / Q000502:physiology; D012074:Remission Induction; D013601:T-Lymphocytes / Q000502:physiology*
D039041:Integrin alpha4beta1; D016023:Integrins; D016169:Lymphocyte Function-Associated Antigen-1; D019713:Receptors, CCR5; D018123:Receptors, Interleukin; D053707:Receptors, Interleukin-12; D016201:Receptors, Lymphocyte Homing; D018664:Interleukin-12