[Study on therapeutical effect of treating hepatolenticular degeneration by the HLD-Tablet I].
OBJECTIVE
To investigate the efficacy of HLD-Tablet I in treating hepatolenticular degeneration (HLD) and its effect on urinary trace element in 24 hours.


METHODS
After 4 weeks of treatment on 34 cases of HLD by oral taken HLD-Tablet I, the clinical practice was closely observed on the patients' change of symptoms, signs and daily life pattern, and measured the level of urinary trace element in 24 hours before the therapy and after that every week.


RESULTS
The total effective rate reached 70.59%, marked effective rate was 8.82%. The effect of treatment was better in the infantile and mild patient. After treatment, the daily output of urinary copper was obviously increased every week than that before (P < 0.01). It was highly negative linear correlated with the duration of treatment (r = -0.96, P < 0.05). But it was insignificantly different between any two weekly excretion of urinary copper per 24 hours after treatment by the HLD-Tablet I (P > 0.05), so its effect on urinary copper excretion was not decreased.


CONCLUSIONS
The HLD-Tablet I could increase the output of urinary copper, hence it was effective in treating HLD without apparent toxic or side reaction.
Hu
W
W
Institute of Neurology, Anhui College of TCM, Hefei (230031).
Yang
R
R
D000293:Adolescent; D000328:Adult; D002648:Child; D003300:Copper / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006527:Hepatolenticular Degeneration / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013607:Tablets
D004365:Drugs, Chinese Herbal; D013607:Tablets; D003300:Copper