New artificial siderophores based on a monosaccharide scaffold.
New artificial catecholate siderophores with methyl alpha-D-glucopyranoside as scaffold were synthesized. The dihydroxy- or di(acetoxy)benzoyl moieties were attached either directly or via aminopropyl spacer groups, to the carbohydrate scaffold. The siderophore activity of the prepared siderophore analogs was examined by a growth promotion assay using various Gram-negative bacteria and mycobacteria and by the CAS-assay.
Heggemann
S
S
Hans Knöll-Institut für Naturstoff-Forschung, Jena, Germany.
Schnabelrauch
M
M
Klemm
D
D
Möllmann
U
U
Reissbrodt
R
R
Heinisch
L
L
D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000254:growth & development; D009682:Magnetic Resonance Spectroscopy; D008757:Methylglucosides / Q000737:chemistry; D015394:Molecular Structure; D009161:Mycobacterium / Q000187:drug effects / Q000254:growth & development; D017262:Siderophores / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology; D021241:Spectrometry, Mass, Electrospray Ionization
D008757:Methylglucosides; D017262:Siderophores; C027020:methylglucoside