Specific kappa opioid receptor agonists.
The results of studies on the design of a heterocyclic scaffold for the dynorphin A pharmacophore and on structure-affinity relationships in the MPCB/CCB series are described. The representative ligands provide insights to binding modes of benzomorphan derivatives to the kappa opioid receptor.
Ronsisvalle
G
G
Department of Pharmaceutical Sciences, University of Catania, Italy. ggrmedch@mbox.unict.it
Marrazzo
A
A
Pasquinucci
L
L
Prezzavento
O
O
Pappalardo
M
M
Vittorio
F
F
D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D015195:Drug Design; D004399:Dynorphins / Q000494:pharmacology; D006801:Humans; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D013329:Structure-Activity Relationship
D000701:Analgesics, Opioid; D017473:Receptors, Opioid, kappa; D004399:Dynorphins