[Histology and tumor biology of microinvasive cervix carcinoma].
Microinvasive squamous cell carcinomas account for up to 21% of cervical carcinomas. In this early tumor stage characterized by a maximum depth of 5 mm and a horizontal growth up to 7 mm even an increase in tumor size of only a few millimeters leads to a worse prognosis. Therefore a morphology-based therapy is needed that requires additional prognostically relevant markers. Depth of invasion and capillary-lymphatic space invasion are the most important prognostic parameters. Detection of invasion-associated proteases might be helpful in searching for additional diagnostic and prognostic markers which are necessary for an optimal staging-related therapy. In future studies specific concerns must be addressed to microinvasive adenocarcinomas to ensure a correct staging and an optimal therapy.
Riethdorf
L
L
Abt. Gynäkopathologie, Institut für Pathologie, Universität Hamburg. riethdof@uke.uni-hamburg.de
D000230:Adenocarcinoma / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002584:Cervix Uteri / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006654:Histology, Comparative; D006801:Humans; D009361:Neoplasm Invasiveness; D011379:Prognosis; D002583:Uterine Cervical Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D002578:Uterine Cervical Dysplasia / Q000145:classification / Q000175:diagnosis* / Q000473:pathology