Reversed-phase high-performance liquid chromatography (RP-HPLC) determination of lipophilicity of furocoumarins: relationship with DNA interaction.
The partition coefficient (P) of 82 furocoumarins and analogs (psoralens, angelicins, allopsoralens, 8-azapsoralens, angular furoquinolin-2-ones, sulfur and selenium isosters of psoralen and angelicin) has been determined by reversed-phase HPLC. The chromatographic behavior correlates well with the in vitro affinity of the compounds toward DNA.
Caffieri
S
S
Department of Pharmaceutical Sciences, The University of Padova, Via F. Marzolo 5, I-35131 Padova, Italy. caffieri@dsfarm.unipd.it
D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003432:Cross-Linking Reagents / Q000737:chemistry / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D003879:Dermatologic Agents / Q000737:chemistry / Q000378:metabolism; D005363:Ficusin / Q000737:chemistry / Q000378:metabolism; D011564:Furocoumarins / Q000737:chemistry* / Q000378:metabolism
D003432:Cross-Linking Reagents; D003879:Dermatologic Agents; D011564:Furocoumarins; D004247:DNA; D005363:Ficusin