title: The presence of v-abl-transformed V3 mast cells in the lungs augments pulmonary vascular permeability to acid aspiration.
abstract: Acid aspiration causes pulmonary vascular permeability and PMN sequestration. By increasing pulmonary mast cells through adoptive transfer of v-abl-transformed mast cells (V3MCs) into BALB/c mice, we now show that the greater mast cell number in the lung is associated with increased pulmonary injury.
authors.affiliation: Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: C
authors.initials: C
authors.lastname: Mukundan
authors.forename: M F
authors.initials: MF
authors.lastname: Gurish
authors.forename: K F
authors.initials: KF
authors.lastname: Austen
authors.forename: H B
authors.initials: HB
authors.lastname: Hechtman
authors.forename: D S
authors.initials: DS
authors.lastname: Friend
mesh_terms: D019264:Adoptive Transfer; D000818:Animals; D015824:Blood-Air Barrier; D004195:Disease Models, Animal; D008297:Male; D008407:Mast Cells / Q000473:pathology*; D008415:Mastocytosis; D051379:Mice; D008807:Mice, Inbred BALB C; D016374:Oncogene Proteins v-abl / Q000235:genetics / Q000302:isolation & purification; D011015:Pneumonia, Aspiration / Q000209:etiology* / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000473:pathology*
chemical_list: D016374:Oncogene Proteins v-abl