title: Motor end-plates in regenerating rat skeletal muscle exposed to botulinum toxin.
abstract: Botulinum toxin type A, when applied to the extensor digitorum longus muscle of rats, reduces spontaneous and evoked transmitter release to a few per cent of the normal level. The toxin, however, fails to affect the morphological redifferentiation of the postsynaptic part of the neuromuscular junction following muscle degeneration-regeneration induced by a selective myotoxic agent, bupivacaine. This indicates that neither transmitter release nor resulting muscle activity are necessary for the differentiation of the sole plate.
authors.affiliation: Institute of Physiology, Czechoslovak Academy of Sciences, Prague.
authors.forename: I
authors.initials: I
authors.lastname: Jirmanová
authors.forename: S
authors.initials: S
authors.lastname: Thesleff
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D001905:Botulinum Toxins / Q000494:pharmacology*; D002045:Bupivacaine / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D008854:Microscopy, Electron; D018482:Muscle, Skeletal / Q000187:drug effects* / Q000294:innervation* / Q000648:ultrastructure; D009416:Nerve Regeneration / Q000187:drug effects* / Q000502:physiology*; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure*; D018377:Neurotransmitter Agents / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D000779:Anesthetics, Local; D018377:Neurotransmitter Agents; D001905:Botulinum Toxins; D002045:Bupivacaine