title: Medical management of osteoarthritis.
abstract: Osteoarthritis (OA) is the most common articular disease, and it continues to be a major public health problem related to pain, disability, loss of time from work, and economics. Most patients with OA seek medical attention because of pain. In the past few years, changes in the treatment of OA have been substantial. More effective nonnarcotic analgesics, cyclooxygenase-2-specific inhibitors, nutraceuticals, and intra-articular hyaluronates are some of the new medications and agents that are now available. The understanding and use of nonpharmacological interventions, including patient education, exercise programs, and weight reduction when appropriate, have also improved. Relief of pain and restoration of function can be accomplished in many patients, particularly with an integrated approach. This article focuses on medical treatment approaches for OA, both pharmacological and nonpharmacological.
authors.affiliation: Division of Rheumatology and Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN 55905, USA.
authors.forename: N J
authors.initials: NJ
authors.lastname: Manek
mesh_terms: D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002807:Chondroitin / Q000008:administration & dosage / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D004338:Drug Combinations; D005081:Exercise Therapy; D005944:Glucosamine / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D010003:Osteoarthritis / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy; D010353:Patient Education as Topic; D011788:Quality of Life; D015431:Weight Loss
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D004338:Drug Combinations; D002807:Chondroitin; D005944:Glucosamine