Analgesic and antiinflammatory activities of vernonioside B2 from Vernonia condensata.
Vernonioside B2 isolated from the methanol extract of the Brazilian herb Vernonia condensata Baker was evaluated in vivo for analgesic and antiinflammatory activities. The compound reduced writhings (93.28%) and Evans blue dye diffusion (91.80%) induced by acetic acid (0.1 N) in a dose-dependent manner.
Valverde
A L
AL
NPPN, Universidade Federal do Rio de Janeiro, CCS, Bloco H, Ilha do Fundão, Rio de Janeiro, Brazil, CEP 21941-590.
Cardoso
G L
GL
Pereira
N A
NA
Silva
A J
AJ
Kuster
R M
RM
D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D019659:Asteraceae; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D005960:Glucosides; D010936:Plant Extracts; C433066:vernonioside B2; D019342:Acetic Acid