title: Optimizing ventilation-perfusion lung scintigraphy: parting with planar imaging.
abstract: OBJECTIVE
  Of the study was to introduce and verify a ventilation-perfusion (V/Q) acquisition protocol that incorporates new developments in scintigraphy in order to allow for a more balanced comparison with other diagnostic procedures.
  
  
  METHODS
  In 103 patients suspect of having pulmonary embolism, V/Q scans were acquired exclusively with SPECT technique. Ventilation was done with ultrafine aerosol. Planar images in eight directions were reconstructed through addition of three consecutive SPECT projections. Three referees examined the scans in regard to type, localization, and extent of V/Q defects.
  
  
  RESULTS
  Using this protocol, significantly more defects, especially of subsegmental size, were detected (p < 0.01). Sensitivity, and diagnostic accuracy were also significantly improved (p < 0.01) to 0.96, and 0.99, respectively. Furthermore, kappa values were increased up to 0.82--a relevant enhancement in the ability to precisely localize V/Q defects.
  
  
  CONCLUSIONS
  In conclusion this protocol provides high-resolution tomographic scans as well as high-quality planar images within a short acquisition time. Due to the significant increase in lesion detection, sensitivity, diagnostic accuracy, and anatomical localization of defects, it is a substantial improvement in the diagnosis of pulmonary embolism that will put V/Q scintigraphy on a par with other tomographic methods.
authors.affiliation: Department of Nuclear Medicine, University Hospital, Aachen University of Technology, Aachen, Germany. preinartz@compuserve.com
authors.forename: P
authors.initials: P
authors.lastname: Reinartz
authors.forename: U
authors.initials: U
authors.lastname: Schirp
authors.forename: M
authors.initials: M
authors.lastname: Zimny
authors.forename: O
authors.initials: O
authors.lastname: Sabri
authors.forename: B
authors.initials: B
authors.lastname: Nowak
authors.forename: W
authors.initials: W
authors.lastname: Schäfer
authors.forename: U
authors.initials: U
authors.lastname: Cremerius
authors.forename: U
authors.initials: U
authors.lastname: Büll
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging* / Q000503:physiopathology; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D014692:Ventilation-Perfusion Ratio