Iron and hepatocellular carcinoma.
The high prevalence of hepatocellular carcinoma (HCC) in genetic hemochromatosis (GH) and the association between increased body iron stores and occurrence of HCC in subjects with iron overload unrelated to GH, and the experimental evidence of a co-carcinogenic role of iron strongly support that iron is involved in the development of HCC.
Deugnier
Y
Y
Clinique des Maladies du Foie, INSERM U522, Hôpital Pontchaillou, Rennes, France. yves.deugnier@univ-rennes1.fr
Turlin
B
B
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D006432:Hemochromatosis / Q000150:complications; D006801:Humans; D007501:Iron / Q000009:adverse effects*; D019190:Iron Overload / Q000150:complications*; D008113:Liver Neoplasms / Q000209:etiology*
D007501:Iron