title: A psychometric comparison of health-related quality of life measures in chronic liver disease.
abstract: Four generic [the Sickness Impact Profile (SIP-68), Short-Form Health Survey (SF-36), EuroQol instrument (EQ-5D), COOP/WONCA charts], two domain-specific health-related quality of life measures [the sexuality scale of the HIV Overview Problems Evaluating System (HOPES), Multi-dimensional Fatigue Index (MFI-20)], and a self-developed 12-item symptom index were compared in terms of feasibility, test-retest reliability, internal consistency reliability, construct validity, and known groups validity in patients with chronic liver disease. All instruments could be completed within 10 min and exhibited a good psychometric performance in patients with chronic liver disease. The SF-36 and the MFI-20 performed relatively best in terms of reliability, construct validity, and discriminative ability. The sexuality scale of the HOPES demonstrated a relatively poor performance, as the missing value rate was higher than 5%. Further research is needed into the sensitivity to important clinical changes of the instruments.
authors.affiliation: Department of Hepatogastroenterology, Erasmus University Hospital Rotterdam, P.O. Box 2040, 3000 CA Rotterdam, Rotterdam, The Netherlands.
authors.forename: G
authors.initials: G
authors.lastname: Unal
authors.forename: J B
authors.initials: JB
authors.lastname: de Boer
authors.forename: G J
authors.initials: GJ
authors.lastname: Borsboom
authors.forename: J T
authors.initials: JT
authors.lastname: Brouwer
authors.forename: M
authors.initials: M
authors.lastname: Essink-Bot
authors.forename: R A
authors.initials: RA
authors.lastname: de Man
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D019538:Health Care Surveys / Q000379:methods*; D006801:Humans; D008107:Liver Diseases; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D011788:Quality of Life; D015203:Reproducibility of Results; D018434:Sickness Impact Profile; D011795:Surveys and Questionnaires