Studying vascular development in the zebrafish.
The zebrafish, a genetically accessible vertebrate with an externally developing, optically clear embryo, is ideally suited for in vivo functional dissection of the embryonic development of the circulatory system. Here, we review the advantages of the zebrafish as a model system for studying vascular development, and describe genetic and experimental tools, methods and resources that have been developed to exploit these advantages. We also discuss briefly how some of these tools and methods can be brought to bear on problems of relevance to human health.
Vogel
A M
AM
Laboratory of Molecular Genetics, NICHD, NIH, Bethesda, MD 20892, USA.
Weinstein
B M
BM
D000818:Animals; D001158:Arteries / Q000033:anatomy & histology / Q000196:embryology / Q000254:growth & development; D001808:Blood Vessels / Q000033:anatomy & histology / Q000196:embryology* / Q000254:growth & development; D019521:Body Patterning / Q000502:physiology*; D047108:Embryonic Development; D016228:Endothelial Growth Factors / Q000502:physiology; D023421:Models, Animal; D009024:Morphogenesis; D018919:Neovascularization, Physiologic; D015398:Signal Transduction; D015027:Zebrafish / Q000196:embryology* / Q000235:genetics
D016228:Endothelial Growth Factors