title: [Gene polymorphisms of hemostasis and coronary risk].
abstract: Hemostatic disorders are substantially involved in the pathogenesis of coronary heart disease and acute coronary syndromes. In addition to biochemical markers, gene polymorphisms of hemostasis have been intensively studied in terms of their association with coronary risk. These include polymorphisms of the genes of platelet glycoproteins, fibrinogen, prothrombin, factors V, VIII and XIII, plasminogen activator inhibitor-1 and tissue-type plasminogen activator. An association of a certain gene polymorphism with an increased coronary risk has usually been demonstrated in retrospective case-control studies. However, numerous clinical studies have not yet been able to identify any of these polymorphisms as unequivocal risk factors of coronary heart disease or acute coronary syndromes. These inconsistencies are mainly due to the complexity of the pathogenesis of coronary heart disease and the minor contribution of a single polymorphism to total coronary risk. This review reports on essential requirements of future studies as a prerequisite to improve our understanding of the genetic basis of coronary heart disease.
authors.affiliation: Institut für Hämostaseologie und Transfusionsmedizin, Ludwigshafen. peterhellstern@medicusnet.de
authors.forename: P
authors.initials: P
authors.lastname: Hellstern
authors.forename: J
authors.initials: J
authors.lastname: Bach
authors.forename: H
authors.initials: H
authors.lastname: Haubelt
authors.forename: A
authors.initials: A
authors.lastname: Preiss
authors.forename: B R
authors.initials: BR
authors.lastname: Winkelmann
authors.forename: J
authors.initials: J
authors.lastname: Senges
mesh_terms: D001779:Blood Coagulation Factors / Q000235:genetics; D001798:Blood Proteins / Q000235:genetics; D003327:Coronary Disease / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006487:Hemostasis / Q000235:genetics*; D006801:Humans; D011110:Polymorphism, Genetic / Q000235:genetics*; D012306:Risk
chemical_list: D001779:Blood Coagulation Factors; D001798:Blood Proteins