title: [Frequency of neural tube defects in public maternity during 1999 in Santiago, Chile].
abstract: BACKGROUND
  Fortification of wheat flour with folic acid in Chile, started in January 2000. This fortification should decrease the incidence of neural tube defects.
  
  
  OBJECTIVE
  To study the incidence of neural tube defects among Chilean newborns, during 1999.
  
  
  METHODS
  The records of all newborns and stillbirths with a birth weight over 500 g from 9 public maternity hospitals in Santiago in 1999, were reviewed. All neural tube defects, associated or not to other malformations were taken into account.
  
  
  RESULTS
  During the study period, 59.627 newborns and 455 stillbirths were analyzed. The global incidence of neural tube defects was 1.56 per 1.000 born (57% women, 42% men and 1% ambiguous sex). Spina bifida was the most frequent neural tube defect found.
  
  
  CONCLUSIONS
  These baseline data will be useful to assess the impact of folic acid fortification of wheat flour.
authors.affiliation: Instituto de Nutrición y Tecnología de los Alimento (INTA), Universidad de Chile, Servicio de Genética, Hospital Clínico de la Universidad de Chile, José Joaquín Aguirre, Santiago, Chile. fcortes@uec.inta.uchile.cl
authors.forename: F
authors.initials: F
authors.lastname: Cortés
authors.forename: C
authors.initials: C
authors.lastname: Mellado
authors.forename: E
authors.initials: E
authors.lastname: Hertrampf
authors.forename: A
authors.initials: A
authors.lastname: Alliende
authors.forename: S
authors.initials: S
authors.lastname: Castillo
mesh_terms: D002677:Chile / Q000453:epidemiology; D005260:Female; D005313:Fetal Death; D005433:Flour; D005492:Folic Acid / Q000008:administration & dosage; D005527:Food, Fortified; D006771:Hospitals, Maternity / Q000706:statistics & numerical data; D006779:Hospitals, Public / Q000706:statistics & numerical data; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009436:Neural Tube Defects / Q000453:epidemiology* / Q000517:prevention & control; D011247:Pregnancy; D017678:Sex Distribution; D014505:Urban Population / Q000706:statistics & numerical data
chemical_list: D005492:Folic Acid