title: Ingestion of gelatin has differential effect on bone mineral density and body weight in protein undernutrition.
abstract: Malnutrition, particularly protein undernutrition, contributes to the occurrence of osteoporotic fracture by lowering bone mass. In this study, the effects of dietary protein on bone mineral density and body weight in protein undernutrition were compared between gelatin and milk casein. When mice were fed for 10 wk with a low protein diet containing 10(%) casein or 6% casein +4% gelatin, there was no significant difference in the final body weight between the 6% casein+4% gelatin group and the 10% casein group. In contrast, bone mineral content and bone mineral density of the femur were significantly higher in the 6% casein+4% gelatin group than in the 10% casein group. Bone mineral content and bone mineral density did not differ significantly in 14% protein groups between 14% casein and 6% casein +80% gelatin. These results suggest that gelatin has differential effects on bone mineral density and body weight in protein undernutrition.
authors.affiliation: Nippi Research Institute of Biomatrix, Nippi Inc., Tokyo, Japan. ykoyama@nippi-inc.co.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Koyama
authors.forename: A
authors.initials: A
authors.lastname: Hirota
authors.forename: H
authors.initials: H
authors.lastname: Mori
authors.forename: H
authors.initials: H
authors.lastname: Takahara
authors.forename: K
authors.initials: K
authors.lastname: Kuwaba
authors.forename: M
authors.initials: M
authors.lastname: Kusubata
authors.forename: Y
authors.initials: Y
authors.lastname: Matsubara
authors.forename: S
authors.initials: S
authors.lastname: Kasugai
authors.forename: M
authors.initials: M
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Irie
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D015519:Bone Density / Q000187:drug effects*; D002364:Caseins / Q000008:administration & dosage / Q000494:pharmacology; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000494:pharmacology; D005269:Femur; D005780:Gelatin / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008892:Milk / Q000737:chemistry; D009748:Nutrition Disorders / Q000150:complications / Q000378:metabolism*
chemical_list: D002364:Caseins; D004044:Dietary Proteins; D005780:Gelatin