Antimicrobial activity of starch dialdehyde dithiosemicarbazone against Mycobacterium tuberculosis.
A dithiosemicarbazone of 13% starch dialdehyde (DASTSC) was active against Mycobacterium tuberculosis under laboratory tests. M. tuberculosis strains sensitive and resistant to isoniazid (INH) were developed at the concentrations of 2.5 x 10(-4)-5.0 x 10(-1) mg/cm3 on a solid Löwenstein-Jensen medium and treated with 1-25 mg/cm3 of DASTSC in all mutual combinations of concentrations. Both, sensitive and resistant to INH strains reacted to DASTSC. The growth of strains could be completely inhibited as proved in eight-week tests. The inhibition was non-linearly dependent on concentration of DASTSC. The lowest and the highest concentrations of DASTSC did not inhibit the M. tuberculosis growth. The doses of DASTSC were optimised.
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Department of Chemistry, University of Agriculture, 21 Mickiewicza Str., 31-120 Kraków.
Klisiewicz-Pańszczyk
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Jurek
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D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013213:Starch / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D013882:Thiosemicarbazones / Q000737:chemistry / Q000494:pharmacology*
D000995:Antitubercular Agents; D013882:Thiosemicarbazones; C015848:dithiosemicarbazone; D013213:Starch; C012880:dialdehyde starch