title: Expression of the non-compact myelin protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) in olfactory bulb ensheathing glia from explant cultures.
abstract: The non-compact myelin protein 2',3'-cyclic nucleotide 3'-phosphodiesterase (CNPase) may have a unique role in signaling pathways mediated by lipid-protein domains (Kim and Pfeiffer, 1999). We have tested for CNPase in olfactory bulb ensheathing glia (OBEG) in explant cultures. Migrating bipolar and multipolar cells with OBEG typical morphologies were inimunoreactive for both vimentin- and S100-like proteins. Although apparently devoid of myelin basic protein (MBP)-like immunoreactivity, these cells displayed weak but unambiguous CNPase-like immunoreactivity. Our results suggest a further resemblance to myelinating Schwann cells.
authors.affiliation: Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-590, Rio de Janeiro, RJ, Brazil.
authors.forename: A
authors.initials: A
authors.lastname: Santos-Silva
authors.forename: L A
authors.initials: LA
authors.lastname: Cavalcante
mesh_terms: D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism*; D000818:Animals; D002465:Cell Movement / Q000502:physiology; D002478:Cells, Cultured / Q000166:cytology / Q000201:enzymology*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D004676:Myelin Basic Protein / Q000378:metabolism*; D009457:Neuroglia / Q000166:cytology / Q000201:enzymology*; D009830:Olfactory Bulb / Q000166:cytology / Q000201:enzymology*; D051381:Rats; D017208:Rats, Wistar; D009418:S100 Proteins / Q000378:metabolism; D012583:Schwann Cells / Q000166:cytology / Q000201:enzymology*; D013234:Stem Cells / Q000166:cytology / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D004676:Myelin Basic Protein; D009418:S100 Proteins; C110294:S100A1 protein; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases