Axon guidance: Robos make the rules.
A central feature of the developing nervous system is the midline region, which guides growing axons with both short- and long-range signals. New research shows that a trio of receptors, the Robos, are crucial in allowing axons to interpret these signals, ensuring correct route-finding within the emerging axon scaffold.
Guthrie
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MRC Centre for Developmental Neurobiology, 4th Floor, New Hunt's House, King's College, Guy's Campus, SE1 1UL, London, UK.
D000818:Animals; D001369:Axons / Q000502:physiology*; D029721:Drosophila Proteins; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D008024:Ligands; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D000097905:Roundabout Proteins
D029721:Drosophila Proteins; D019476:Insect Proteins; D008024:Ligands; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; C421243:Robo2 protein, Drosophila; C421244:robo3 protein, Drosophila; C066819:sli protein, Drosophila