A mathematical model describing the thermal virus inactivation.
A new mathematical model is proposed to describe the inactivation of viruses at different temperatures. This model takes into account the exponential decrease of the viral titer with time, the inactivation rate being an exponential function of the temperature. A one-step non-linear regression was used to fit oral poliovirus vaccine (OPV) experimental data. In one of the applications of the model, we illustrate the use of our model to compare the accelerated degradation test of OPV new formulations to standard OPV. Such a model is both simple and convenient to use. It should be a useful tool in optimizing formulations for live viral vaccines.
Noël
C
C
Development Department, Aventis Pasteur, 69280, Marcy l'Etoile, France. catherine.noel@aventis.com
Charles
S
S
Françon
A
A
Flandrois
J P
JP
D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D008962:Models, Theoretical; D011055:Poliovirus Vaccine, Oral / Q000037:antagonists & inhibitors / Q000737:chemistry; D013696:Temperature; D014765:Viral Vaccines / Q000037:antagonists & inhibitors* / Q000737:chemistry*
D011055:Poliovirus Vaccine, Oral; D014765:Viral Vaccines