title: Clear-cell odontogenic carcinoma with pulmonary metastases resembling pulmonary meningothelial-like nodules.
abstract: Clear-cell odontogenic carcinoma (CCOC) is a rare neoplasm with malignant potential and unknown cytogenetic alterations. We describe the case of a 43-year-old woman who presented with an unusual odontogenic epithelial tumor. Histologically, the tumor was composed of clear-cell areas and exhibited a squamous pattern with little nuclear pleomorphism similar to benign squamous odontogenic tumor. Multiple small pulmonary nodules occurring 3 years after primary surgical treatment histologically closely resembled benign minute pulmonary meningothelial-like nodules (MPMN) with clear-cell features. Comparative genomic hybridization (CGH) and immunohistochemistry, performed as diagnostic adjuncts, revealed in the odontogenic tumor and the pulmonary lesions a very similar pattern of chromosomal aberrations (loss of 9, gains of 14q, 19 and 20 in both, and additional loss of 6 in the odontogenic tumor) and the same pattern of expression (positive for cytokeratin 5, 6, 8, 19 and negative for cytokeratin 18, epithelial membrane antigen, and vimentin), differing from that of MPMN. These findings confirmed the final diagnosis of metastasizing CCOC with partial squamous differentiation, substantiated the unfavorable prognosis of the clear-cell component, and highlighted the diagnostic impact of CGH and immunohistochemistry for classification of these morphologically peculiar pulmonary CCOC metastases.
authors.affiliation: Department of Pathology, Georg-August University, Robert Koch Strasse 40, 37075 Göttingen, Germany. ubrinck@aol.com
authors.forename: U
authors.initials: U
authors.lastname: Brinck
authors.forename: B
authors.initials: B
authors.lastname: Gunawan
authors.forename: H J
authors.initials: HJ
authors.lastname: Schulten
authors.forename: W
authors.initials: W
authors.lastname: Pinzon
authors.forename: U
authors.initials: U
authors.lastname: Fischer
authors.forename: L
authors.initials: L
authors.lastname: Füzesi
mesh_terms: D018262:Adenocarcinoma, Clear Cell / Q000737:chemistry / Q000235:genetics / Q000556:secondary*; D000328:Adult; D000564:Ameloblastoma / Q000737:chemistry / Q000235:genetics / Q000556:secondary*; D000782:Aneuploidy; D014408:Biomarkers, Tumor / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007573:Jaw Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary*; D009363:Neoplasm Proteins / Q000032:analysis; D009693:Nucleic Acid Hybridization; D010236:Paraganglioma, Extra-Adrenal / Q000473:pathology*; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed
chemical_list: D014408:Biomarkers, Tumor; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins