title: Quantitative comparison of ohmefentanyl isomers induced conditioning place preference in mice.
abstract: Differences of analgesia and withdrawal response among ohmefentanyl stereoisomers have been studied. In the present study, Quantitative comparison of reinforcing effects of ohmefentanyl stereoisomers and morphine was performed by using a conditioned place preference design in mice. Results showed that morphine and ohmefentanyl stereoisomers were able to increase significantly the time spent in the drug-paired side with respect to vehicle treated animals. A good linear correlation between doses of drugs and number of mice with place preference was found within a given dose range. On the basis of the dose-response curve analysis, ohmefentanyl stereoisomers displayed a significant difference in place preference ED50. The addictive index (analgesic ED50/place preference ED50) was used to assess the addictive potential of drugs. It was demonstrated that the addictive potential of ohmefentanyl stereoisomers did not exhibit a large difference as addictive index. Among these stereoisomers, the addictive potential of compound F9208 was markedly lower than that of morphine.
authors.affiliation: Shanghai Institute of Meteria Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences.
authors.forename: G W
authors.initials: GW
authors.lastname: Guo
authors.forename: Z H
authors.initials: ZH
authors.lastname: Liu
authors.forename: W Q
authors.initials: WQ
authors.lastname: Jin
authors.forename: H P
authors.initials: HP
authors.lastname: Zhang
authors.forename: X J
authors.initials: XJ
authors.lastname: Chen
authors.forename: Y C
authors.initials: YC
authors.lastname: Zhu
authors.forename: Z Q
authors.initials: ZQ
authors.lastname: Chi
mesh_terms: D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D016739:Behavior, Addictive / Q000139:chemically induced; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005283:Fentanyl / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007536:Isomerism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology; D012054:Reinforcement, Psychology
chemical_list: D000701:Analgesics, Opioid; D009020:Morphine; C037016:F 7302; D005283:Fentanyl