Arylsulphatase A and 2',3'-cyclic nucleotide 3'-phosphohydrolase activities in the brains of myelin deficient mutant mice.
Arylsulphatase A and 2',3'-cyclic nucleotide 3'-phosphohydrolase activities of myelin deficient mutant mice brains were studied. The results indicated that there were no changes in arylsulphatase A activity of the developing mutant brain, whereas the activity of 2',3'-cyclic nucleotide 3'-phosphohydrolase decreased considerably. The data obtained in this study suggest that in brain arylsulphatase A activity is localized in cells other than oligodendroglia.
Sarlieve
L L
LL
Centre de Neurochimie du CNRS, and Institut de Chimie Biologique, Faculté de Médecine, 11 rue Humann, 67085 Strasbourg, France.
Farooqui
A A
AA
Rebel
G
G
Mandel
P
P
D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism*; D001921:Brain / Q000201:enzymology* / Q000254:growth & development / Q000503:physiopathology; D001923:Brain Chemistry / Q000235:genetics*; D005260:Female; D005700:Galactosyltransferases; D051147:Ganglioside Galactosyltransferase; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000378:metabolism*; D009186:Myelin Sheath / Q000201:enzymology* / Q000235:genetics; D011609:Psychosine / Q000378:metabolism
D011609:Psychosine; D005700:Galactosyltransferases; C511214:Ugt8a protein, mouse; D051147:Ganglioside Galactosyltransferase; D015087:2',3'-Cyclic-Nucleotide Phosphodiesterases; D001192:Arylsulfatases