title: Reduced immunoglobulin kappa/lambda light chain ratio in perinatally HIV-1-infected children.
abstract: In 27 perinatally human immunodeficiency virus type 1 (HIV-1)-infected children, we measured, by immunonephelometry, the kappa/lambda light chain ratio (KLR) of serum immunoglobulins. The latter is a recently available laboratory index reflecting the balance between the synthesis of K isotypes and L isotypes. KLR was consistent over time in each subject, and was significantly lower than that of an age-matched normal population, independently of disease status and therapy. These data indicate a bias, in these subjects, to produce preferentially lambda rather than kappa light chains, contributing to the multiple B-cell abnormalities in HIV-1-infected children.
authors.affiliation: Laboratory of Clinical Chemistry and Microbiology, Regina Margherita Children's Hospital, Turin, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Saitta
authors.forename: F
authors.initials: F
authors.lastname: Gaido
authors.forename: E
authors.initials: E
authors.lastname: Palomba
authors.forename: P
authors.initials: P
authors.lastname: Cirina
authors.forename: A
authors.initials: A
authors.lastname: Giaccone
authors.forename: E
authors.initials: E
authors.lastname: Ciuti
authors.forename: P
authors.initials: P
authors.lastname: Tovo
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000635:transmission; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D015483:HIV Antibodies / Q000096:biosynthesis; D015497:HIV-1 / Q000276:immunology; D006801:Humans; D007145:Immunoglobulin kappa-Chains / Q000096:biosynthesis*; D007146:Immunoglobulin lambda-Chains / Q000096:biosynthesis*; D007223:Infant; D018445:Infectious Disease Transmission, Vertical; D008297:Male; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000453:epidemiology / Q000276:immunology
chemical_list: D015483:HIV Antibodies; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains