title: Discovery of potent and selective phenylalanine derived CCR3 receptor antagonists. Part 2.
abstract: Highly potent CCR3 antagonists have been developed from a previously reported series of phenylalanine ester-based leads. Solution-phase, parallel synthesis optimization was utilized to identify highly potent, functional CCR3 antagonists.
authors.affiliation: SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426-0989, USA. dhanak-1@sbphrd.com
authors.forename: D
authors.initials: D
authors.lastname: Dhanak
authors.forename: L T
authors.initials: LT
authors.lastname: Christmann
authors.forename: M G
authors.initials: MG
authors.lastname: Darcy
authors.forename: R M
authors.initials: RM
authors.lastname: Keenan
authors.forename: S D
authors.initials: SD
authors.lastname: Knight
authors.forename: J
authors.initials: J
authors.lastname: Lee
authors.forename: L H
authors.initials: LH
authors.lastname: Ridgers
authors.forename: H M
authors.initials: HM
authors.lastname: Sarau
authors.forename: D H
authors.initials: DH
authors.lastname: Shah
authors.forename: J R
authors.initials: JR
authors.lastname: White
authors.forename: L
authors.initials: L
authors.lastname: Zhang
mesh_terms: D006801:Humans; D010649:Phenylalanine / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
chemical_list: C515350:CCR3 protein, human; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; D010649:Phenylalanine