title: New crystal forms of Trypanosoma cruzi dUTPase.
abstract: The dUTPase from Trypanosoma cruzi has been crystallized in two crystal forms, both belonging to space group P6(3)22, with unit-cell parameters a = b = 134.67, c = 148.66 A (form I, two molecules per asymmetric unit) and a = b = 136.43, c = 68.71 A (form II, one molecule per asymmetric unit). Single-wavelength data have been collected using synchrotron radiation to 3.0 A for crystal form I and to 2.4 A for crystal form II and structure solution is under way. T. cruzi dUTPase is a potential target for anti-protozoan drug design.
authors.affiliation: Structural Biology Laboratory, Department of Chemistry, University of York, Heslington, York YO10 5DD, England.
authors.forename: M
authors.initials: M
authors.lastname: Harkiolaki
authors.forename: A M
authors.initials: AM
authors.lastname: Brzozowski
authors.forename: D
authors.initials: D
authors.lastname: Gonzalez-Pacanowska
authors.forename: F
authors.initials: F
authors.lastname: Hidalgo-Zarco
authors.forename: K S
authors.initials: KS
authors.lastname: Wilson
mesh_terms: D000818:Animals; D003460:Crystallization; D018360:Crystallography, X-Ray; D011487:Protein Conformation; D011755:Pyrophosphatases / Q000737:chemistry*; D011994:Recombinant Proteins / Q000737:chemistry; D014349:Trypanosoma cruzi / Q000201:enzymology*
chemical_list: D011994:Recombinant Proteins; D011755:Pyrophosphatases; C020020:dUTP pyrophosphatase