Intercostal nerve neurouma (PNS) implantation in spinal cord bridging spinal cord transection a functional internuncal pathway system result in recovery from paraplegia.
In these studies 76 mature female dogs were used. The spinal cord was transacted at T6 or T8. The intercostal nerve or nerves originating cephalic to the transaction were inserted into the distal isolated cord close to the transaction and plasma clot sutured to anchor the peripheral end of the nerve into the spinal cord. The transacted isolated spinal cord at the mid thoracic level results in paraplegia. 3, 4, 21 The isolated distal transacted spinal cord is capable of producing complex, detailed locomotor functions. The anatomical substrate is produced by systems of interconnected interneurons in the lumbar spinal cord that forms the central pattern generators (CPG). 3, 4, 21 The interneurons comprising (CPG) coordinates patterned movements of the rear limbs as flexion, extension, weight bearing, postural adjustments and alternating patterned limb movements. 3, 4, 21 In the case of implantation of a peripheral nerve distal stump into the transacted spinal cord the procedure enhances the function mediated by the central patterned generators (CPG) by training, conditioning and chemical and molecular treatments. 3, 4, 7, 8, 15, 1, 18, 19, 21.
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Department of Biomedical Sciences, Creighton University, Omaha, NE 68178, USA.
D000818:Animals; D001369:Axons / Q000502:physiology; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D007367:Intercostal Nerves / Q000502:physiology / Q000637:transplantation*; D007395:Interneurons / Q000502:physiology*; D008124:Locomotion; D009416:Nerve Regeneration; D009434:Neural Pathways; D010264:Paraplegia / Q000209:etiology* / Q000503:physiopathology; D020127:Recovery of Function; D013116:Spinal Cord / Q000601:surgery*; D013119:Spinal Cord Injuries / Q000150:complications / Q000601:surgery*