title: DNA replication: building the perfect switch.
abstract: A sophisticated molecular switch ensures that replication origins are activated just once in each cell cycle. Recent work reveals how the proteolysis of a key replication inhibitor, geminin, by the anaphase promoting complex/cyclosome is an important component of this switch.
authors.affiliation: ICRF Clare Hall Laboratories, South Mimms, EN6 3LD, UK. J.Diffley@icrf.icnet.uk
authors.forename: J F
authors.initials: JF
authors.lastname: Diffley
mesh_terms: D000818:Animals; D018844:Cyclin-Dependent Kinases / Q000502:physiology; D004261:DNA Replication; D015894:Genome, Human; D006801:Humans
chemical_list: D018844:Cyclin-Dependent Kinases