[Studies on the mechanism of alpha-MSH in reducing IL-1 beta-induced fever].
The effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on IL-1 beta-induced fever and release of hypothalamic cAMP was observed in the present work. The results showed that alpha-MSH markedly suppressed febrile response (P < 0.05) and decreased the cAMP content in hypothalamus in response to icv injection of IL-1 beta (P < 0.01). The cAMP content of the medium in which the hypothalamic was incubated for 40 min in the presence of IL-1 beta was significantly increased (P < 0.01). However, this increase action could be prevented by a pretreatment with alpha-MSH. The results indicate that the inhibitory effect of alpha-MSH on the enhanced synthesis and release of cAMP in hypothalamus exposed to IL-1 beta might be one of the mechanisms of suppressing fever induced by IL-1 beta.
Hu
C F
CF
Department of Pathophysiology and Institute of Fever Research, Medical College, Jinan University, Guangzhou 510632.
Wang
H D
HD
Wang
D A
DA
Wang
Y P
YP
Li
C J
CJ
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D005334:Fever / Q000139:chemically induced; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D007267:Injections; D007276:Injections, Intraventricular; D007375:Interleukin-1; D008297:Male; D008845:Microinjections; D011817:Rabbits; D000521:alpha-MSH / Q000494:pharmacology*
D018712:Analgesics, Non-Narcotic; D007375:Interleukin-1; D000521:alpha-MSH; D000242:Cyclic AMP