A non-sense mutation in Cd36 gene is associated with protection from severe malaria.
We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria. We identified a non-sense mutation in Cd36 gene and looked at the influence of this mutation on the outcome of malaria infection in 693 African children with severe malaria and a similar number of ethnically matched controls. We showed that heterozygosity for this mutation is associated with protection from severe disease (OR 0.74, 95% CI 0.55-0.99; p=0.036). These findings suggest that this Cd36 mutation might have a complex effect on malaria infection by decreasing parasite sequestration, and also by decreasing host immune responses.
Pain
A
A
Urban
B C
BC
Kai
O
O
Casals-Pascual
C
C
Shafi
J
J
Marsh
K
K
Roberts
D J
DJ
D018955:CD36 Antigens / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D018389:Codon, Nonsense; D005260:Female; D006580:Genetic Carrier Screening; D006790:Host-Parasite Interactions / Q000235:genetics; D006801:Humans; D007223:Infant; D007630:Kenya; D016779:Malaria, Cerebral / Q000235:genetics; D016778:Malaria, Falciparum / Q000235:genetics* / Q000517:prevention & control; D008297:Male
D018955:CD36 Antigens; D018389:Codon, Nonsense