[New immunosuppressive drugs and diabetes].
Glucocorticoïds, calcineurin inhibitors (especially tacrolimus) and the combination of both are responsible for the occurrence of diabetes mellitus after organ transplantation. These drugs induce both insulin resistance and insulinopenia. Risks factors are well identified: high doses of immunosuppressive drugs, genetic background, age and weight excess. Long-term consequences seem to be as deleterious as those of other types of diabetes mellitus. Modulating the doses of immunosuppressive drugs is efficient in decreasing insulin requirement in transplant recipients but only individualization of immunosuppression taking risks factors into account will permit to decrease the incidence of this side-effect.
Legendre
C
C
Service de Néphrologie, Hôpital Saint-Louis, 1, av. C. Vellefaux, 75010 Paris.
Thervet
E
E
Bédrossian
J
J
D003920:Diabetes Mellitus / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects / Q000379:methods; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D015994:Incidence; D007333:Insulin Resistance; D014181:Transplantation Immunology
D007166:Immunosuppressive Agents