title: The role of Glial-Pial barrier lesions and impaired vascularization in anomalous formation of cortical convolutions.
abstract: The abnormal patterns of cerebral convolutions range from severe to small anomalies restricted to tertiary gyri and sulci. Lesions within Glial-Pial barrier were found in examined cases with cortical developmental abnormalities. Anomalies and impaired function of vessels penetrating the cortex from meningeal plexus coexisted often with Glial-Pial barrier lesions. We are able to say that our cases constitute a group of graded changes demonstrating that both observed developmental lesions vascular and/or Glial-Pial barrier damage may result in cortical anomalies. Their formation and character depend on the stage of cortical maturation when analyzed lesions occur.
authors.affiliation: Department of Developmental Neuropathology, Medical Research Centre, Polish Academy of Sciences, 5 Pawinskiego, 02-106, Warsaw, Poland. milenak@cmdik.pan.pl
authors.forename: M
authors.initials: M
authors.lastname: Dambska
authors.forename: M
authors.initials: M
authors.lastname: Laure-Kamionowska
mesh_terms: D002540:Cerebral Cortex / Q000002:abnormalities* / Q000098:blood supply / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000473:pathology*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D009457:Neuroglia / Q000473:pathology*; D010841:Pia Mater / Q000002:abnormalities* / Q000473:pathology; D011247:Pregnancy