title: [Frequency of hypothyroidism after De Quervain thyroiditis and contribution of ultrasonographic thyroid volume measurement].
abstract: Subacute thyroiditis conventionally recovers without after-effect. Nevertheless some data relate a 5 to 9% occurrence of final hypothyroidism 6 months after the acute stage. We herein studied end-stage hypothyroidism occurrence and effect of thyroid volume alterations on hormonal course during thyroiditis. Twenty-nine cases of subacute thyroiditis were studied. Final thyroid function remained normal in 15 patients (51%) and undetermined in 5 patients (17%). Final hypothyroidism (TSH: 4.5-14.5 microU/mL) occurred in 9 patients (31%). Mean thyroid volume was increased in acute stage in patients with final normal thyroid function (16.6+/-5.7cm(3)) and decreased by 63% during follow-up; final mean thyroid volume was 6.1+/-1.3cm(3). Mean thyroid volume was normal in acute stage in final hypothyroid patients (10.7+/-3.0cm(3)) and decreased by 72% during follow-up; final mean thyroid volume was 3.3+/-1.1cm(3). End-stage mean thyroid volume was significantly lower in final hypothyroid patients (p<0.05) compared to patients with final normal thyroid function. We conclude that the occurrence of final hypothyroidism is underestimated after subacute thyroiditis. Ultrasonographic follow-up might be helpful in the detection of final hypothyroid-risk patients: thyroid volume not increased in acute stage and lower than 5cm(3) during follow-up is one of the ultrasonographic features of these patients.
authors.affiliation: Groupe de Recherches Cliniques en Endocrinologie, 5, rue Dupin, 75006 Paris.
authors.forename: J P
authors.initials: JP
authors.lastname: Cordray
authors.forename: P
authors.initials: P
authors.lastname: Nys
authors.forename: R E
authors.initials: RE
authors.lastname: Merceron
authors.forename: A
authors.initials: A
authors.lastname: Augusti
mesh_terms: D000208:Acute Disease; D000328:Adult; D015982:Bias; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000000981:diagnostic imaging* / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D013960:Thyroid Function Tests; D013968:Thyroiditis, Subacute / Q000150:complications*; D013972:Thyrotropin / Q000097:blood; D014463:Ultrasonography / Q000379:methods / Q000592:standards
chemical_list: D013972:Thyrotropin