title: Bacterial fatty-acid biosynthesis: a genomics-driven target for antibacterial drug discovery.
abstract: In this review we demonstrate how the interplay of genomics, bioinformatics and genomic technologies has enabled an in-depth analysis of the component enzymes of the bacterial fatty-acid biosynthesis pathway as a source of novel antibacterial targets. This evaluation has revealed that many of the enzymes are potentially selective, broad-spectrum antibacterial targets. We also illustrate the suitability of some of these targets for HTS. Furthermore, we discuss how the availability of a robust selectivity assay, mode-of-action assays and numerous crystal structures provide an excellent set of tools with which to initiate integrated programs of research to identify novel antibiotics targeted at these enzymes.
authors.affiliation: Antimicrobials and Host Defence, 1250 South Collegeville Road, 19426, Collegeville, PA, USA
authors.forename: D J.
authors.initials: DJ
authors.lastname: Payne
authors.forename: P V.
authors.initials: PV
authors.lastname: Warren
authors.forename: D J.
authors.initials: DJ
authors.lastname: Holmes
authors.forename: Y
authors.initials: Y
authors.lastname: Ji
authors.forename: J T.
authors.initials: JT
authors.lastname: Lonsdale