Cancer chemotherapy--ribonucleases to the rescue.
Ribonucleases, once dismissed as uninteresting digestive enzymes, have been shown to have remarkable biological activities. Onconase, from the Northern leopard frog, is currently in clinical trials as a cancer chemotherapeutic. Recent research has revealed some key factors responsible for the cytotoxicity of ribonucleases, and may lead to a new class of drugs.
Leland
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PA
Department of Biochemistry, University of Wisconsin-Madison, 53706, USA.
Raines
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RT
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003600:Cytosol / Q000201:enzymology / Q000648:ultrastructure; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy*; D009865:Oocytes / Q000166:cytology / Q000201:enzymology; D011898:Ranidae / Q000196:embryology; D012259:Ribonuclease, Pancreatic / Q000494:pharmacology / Q000627:therapeutic use; D012260:Ribonucleases / Q000494:pharmacology* / Q000627:therapeutic use* / Q000633:toxicity; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D012260:Ribonucleases; D012259:Ribonuclease, Pancreatic; C058703:ranpirnase