Acute effects of growth hormone on metabolism of pancreatic hormones, glucose and ketone bodies.
Controversy exists as to whether acute administration of growth hormone has insulin-like effects. In conscious dogs, acute effects on plasma flows, plasma glucose, hepatic glucose output, free fatty acids, ketone bodies, insulin, and glucagon were determined following intravenous injection of 1 mg of growth hormone extracted from the canine pituitary gland. The following results were obtained: (1) Plasma flows in the portal vein, hepatic artery and hepatic vein were significantly increased 20 min after growth hormone administration. (2) By 40 min after growth hormone, the glucose concentration in these three vessels was significantly increased. (3) Hepatic glucose output was significantly increased 60 min after growth hormone administration. (4) Free fatty acids levels were significantly but transiently increased at 20 min, while ketone body concentrations were elevated at 120-180 min. (5) The insulin levels in the three vessels demonstrated a biphasic response. In the portal vein, they were significantly higher 20 min after growth hormone and again at 150-180 min. Glucagon concentrations were increased in all three vessels by 20 min and remained elevated for the remainder of the experiment. These results do not support an acute insulin-like action of growth hormone in normal dogs.
Okuda
Y
Y
Diabetes Research Laboratory, Division of Endocrinology and Metabolism, Department of Medicine, St. Lukes Episcopal Hospital, Baylor College of Medicine, Houston, TX, USA.
Peña
J
J
Chou
J
J
Field
J B
JB
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects / Q000502:physiology*; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005934:Glucagon / Q000097:blood* / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D006499:Hepatic Artery / Q000187:drug effects / Q000502:physiology; D006503:Hepatic Veins / Q000187:drug effects / Q000502:physiology; D007275:Injections, Intravenous; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism; D007657:Ketone Bodies / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D011169:Portal Vein / Q000187:drug effects / Q000502:physiology
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007657:Ketone Bodies; D013006:Growth Hormone; D005934:Glucagon; D005947:Glucose