title: A novel diffusible substance can overcome the apparent AbrB repression of the Bacillus subtilis fatR promoter.
abstract: In this work we present evidence for a novel diffusible extracellular factor that modulates gene expression in Bacillus subtilis. The factor was found when studying the regulation of the fatR-cyp102A3 operon. In a Spo0A(-) mutant expression of the fatR-cyp102A3 operon was almost abolished. The fatR-cyp102A3 expression defect of a Spo0A(-) mutant could be overcome either by a mutation in the abrB gene or by a diffusible substance excreted by wild-type, abrB mutant and abrB-spo0A double mutant strains.
authors.affiliation: Department of Microbiology, Lund University, Sölvegatan 12, SE-22362, Lund, Sweden.
authors.forename: M C
authors.initials: MC
authors.lastname: Gustafsson
authors.forename: C
authors.initials: C
authors.lastname: von Wachenfeldt
mesh_terms: D001412:Bacillus subtilis / Q000235:genetics*; D001426:Bacterial Proteins; D001692:Biological Transport; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D004058:Diffusion; D017353:Gene Deletion; D015964:Gene Expression Regulation, Bacterial; D020868:Gene Silencing; D005816:Genetic Complementation Test; D006899:Mixed Function Oxygenases / Q000235:genetics; D009154:Mutation; D009251:NADPH-Ferrihemoprotein Reductase; D009842:Oligopeptides / Q000378:metabolism; D009876:Operon; D011401:Promoter Regions, Genetic / Q000235:genetics*; D014157:Transcription Factors / Q000235:genetics*
chemical_list: C060762:AbrB protein, Bacillus subtilis; D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D009842:Oligopeptides; D014157:Transcription Factors; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D009251:NADPH-Ferrihemoprotein Reductase; C052423:flavocytochrome P450 BM3 monoxygenases