Cardiac remodeling after myocardial infarction is impaired in IGF-1 deficient mice.
OBJECTIVE
To obtain more insight in the role of IGF-1 in cardiac remodeling and function after experimental myocardial infarction. We hypothesized that cardiac remodeling is altered in IGF-1 deficient mice, which may affect cardiac function.


METHODS
A myocardial infarction was induced by surgical coronary artery ligation in heterozygous IGF-1 deficient mice. One week after surgery, left ventricular function was analyzed, and parameters of cardiac remodeling were measured.


RESULTS
No significant difference in cardiac function was found between infarcted wildtype and knock-out animals, despite a marked reduction in capillarization and blunting of the hypertrophic response of the interventricular septum in the IGF-1 deficient group. Furthermore, decreased DNA synthesis and increased apoptosis rates were observed in the IGF-1 knock-out mice.


CONCLUSIONS
IGF-1 deficient mice show preservation of cardiac function 1 week after MI, despite an altered cardiac remodeling process.
Palmen
M
M
Department of Cardiology, Cardiovascular Research Institute, University of Maastricht, The, Maastricht, Netherlands.
Daemen
M J
MJ
Bronsaer
R
R
Dassen
W R
WR
Zandbergen
H R
HR
Kockx
M
M
Smits
J F
JF
van der Zee
R
R
Doevendans
P A
PA
D000818:Animals; D017209:Apoptosis; D001835:Body Weight / Q000502:physiology; D002196:Capillaries / Q000473:pathology; D003331:Coronary Vessels / Q000473:pathology; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007334:Insulin-Like Growth Factor I / Q000172:deficiency* / Q000502:physiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009203:Myocardial Infarction / Q000473:pathology / Q000503:physiopathology*; D009929:Organ Size / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology; D020257:Ventricular Remodeling / Q000502:physiology*
D007334:Insulin-Like Growth Factor I; D004247:DNA