Evaluation of the human nickel retention model with workplace data.
A previously developed dosimetry model of inhaled Ni compounds in the human lung has been expanded by incorporating three additional factors: (1) inhalability, (2) mixed breathing mode, and (3) clearance rate coefficient of a Ni compounds' mixture. Predicted lung burdens of Ni compounds from the expanded model for workers at different departments in a Ni refinery plant compared favorably with the reported data. Although many uncertainties remain, the present model represents a first step toward developing a more meaningful risk assessment tool that will allow for more accurate extrapolation of animal data to humans.
Yu
C P
CP
Department of Mechanical and Aerospace Engineering, State University of New York at Buffalo, Amherst, NY 14260, USA. chiayu@acsu.buffalo.edu
Hsieh
T H
TH
Oller
A R
AR
Oberdörster
G
G
D000368:Aged; D000818:Animals; D006801:Humans; D019570:Inhalation Exposure; D008168:Lung / Q000737:chemistry*; D008297:Male; D008954:Models, Biological; D009532:Nickel / Q000493:pharmacokinetics*; D016273:Occupational Exposure; D012119:Respiration; D018570:Risk Assessment; D017132:Workplace
D009532:Nickel