Opportunities and strategies for introducing pharmacogenetics into early drug development.
Following the publication of the first draft of the human genome, this is a good time to re-analyse the potential contribution of genomics to drug development. Pharma, biotech and academia are already queuing up to deliver novel data impinging on every aspect of medicine and we can foresee a five-year scenario in which every new drug with a known mode of action will have a target gene sequence in the public domain. As such, current development strategies must ultimately be capable of anticipating and addressing genetic issues. This article attempts to position recent developments in genomics from an industrial perspective.
Chamberlain
J C.
JC
Roche Products, 40 Broadwater Rd, AL7 3AY, Welwyn Garden City, UK
Joubert
P H.
PH