title: Effects of the oral spirochete Treponema denticola on interleukin-8 expression from epithelial cells.
abstract: This communication demonstrates that the interaction of the oral spirochete Treponema denticola 35405 with KB epithelial cells does not lead to the induction of interleukin-8 production as occurs with a variety of other bacteria. Utilizing the dentilisin protease mutant K1 of T. denticola, this property was demonstrated to be primarily a function of the expression of the protease by strain 35405.
authors.affiliation: Department of Oral Biology, State University of New York, Buffalo, NY 14214, USA.
authors.forename: Q D
authors.initials: QD
authors.lastname: Deng
authors.forename: Y
authors.initials: Y
authors.lastname: Han
authors.forename: X
authors.initials: X
authors.lastname: Xia
authors.forename: H K
authors.initials: HK
authors.lastname: Kuramitsu
mesh_terms: D001426:Bacterial Proteins; D002918:Chymotrypsin / Q000235:genetics; D004797:Enzyme-Linked Immunosorbent Assay; D004847:Epithelial Cells / Q000276:immunology* / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D006801:Humans; D016209:Interleukin-8 / Q000096:biosynthesis*; D009055:Mouth / Q000382:microbiology; D009154:Mutation / Q000235:genetics; D010447:Peptide Hydrolases; D014208:Treponema / Q000145:classification / Q000201:enzymology / Q000235:genetics / Q000276:immunology*
chemical_list: D001426:Bacterial Proteins; D016209:Interleukin-8; D010447:Peptide Hydrolases; C102570:dentilisin; D002918:Chymotrypsin