Dribble, the Drosophila KRR1p homologue, is involved in rRNA processing.
The Drosophila dribble (dbe) gene encodes a KH domain protein, homologous to yeast KRR1p. Expression of dbe transcripts is ubiquitous during embryogenesis. Overexpressed Dribble protein is localized in the nucleus and in some cell types in a subregion of the nucleolus. Homozygous dbe mutants die at first instar larval stage. Clonal analyses suggest that dbe(+) is required for survival of dividing cells. In dbe mutants, a novel rRNA-processing defect is found and accumulation of an abnormal rRNA precursor is detected.
Chan
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Department of Genetics, University of Cambridge, Cambridge CB2 3EH, England, United Kingdom.
Brogna
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O'Kane
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D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D001483:Base Sequence; D002467:Cell Nucleus / Q000378:metabolism; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000502:physiology; D004625:Embryo, Nonmammalian / Q000502:physiology; D020224:Expressed Sequence Tags; D005260:Female; D017344:Genes, Insect; D017930:Genes, Reporter; D006801:Humans; D019476:Insect Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D008297:Male; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D009865:Oocytes / Q000378:metabolism; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D012323:RNA Processing, Post-Transcriptional; D012335:RNA, Ribosomal / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism
D029721:Drosophila Proteins; D019476:Insect Proteins; D009687:Nuclear Proteins; D012335:RNA, Ribosomal; D011993:Recombinant Fusion Proteins; C434386:dbe protein, Drosophila