Analogues of polyamine alkaloids and their synthetic advantages.
Several polyamine derivatives were synthesized in order to produce novel antagonists of muscular nicotinic acetylcholine receptors. Their affinities were compared with those of philanthotoxin PhTX-343.
Li
Y
Y
Organisch-chemisches Institut, Universität Zürich, Switzerland.
Popaj
K
K
Lochner
M
M
Geneste
H
H
Budriesi
R
R
Chiarini
A
A
Melchiorre
C
C
Hesse
M
M
D000818:Animals; D006801:Humans; D018733:Nicotinic Antagonists / Q000138:chemical synthesis* / Q000494:pharmacology; D011073:Polyamines / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D018733:Nicotinic Antagonists; D011073:Polyamines