NMR studies on three optical active drug molecules.
NMR spectroscopy is one of very few methods that enable deep insight into molecular structure and distinguishing of enantiomers. It usually requires the use of optically active agents that differentiate S and R forms through an interaction with studied molecule differentiate S and R forms. The aim of the present studies was to perform a preliminary NMR study on three chiral drugs: Fluoxetine hydrochloride, Ibuprofen, and Zolmitriptan by use of three optical solvating agents: R(-) 2,2,2-trifluoro-1-(9-anthryl)ethanol (I), (R)(+) 1,1'-bi-2-naphthol (II), and (S) tert-butyl-phenylphosphinothioic acid (III).
Bednarek
E
E
Drug Institute, 30/34 Chełmska Str. 00-725 Warsaw, Poland.
Dobrowolski
J C
JC
Mazurek
A P
AP
D016861:Cyclooxygenase Inhibitors / Q000737:chemistry*; D005473:Fluoxetine / Q000737:chemistry*; D007052:Ibuprofen / Q000737:chemistry*; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D009904:Optical Rotation; D023303:Oxazolidinones / Q000737:chemistry*; D017366:Serotonin Receptor Agonists / Q000737:chemistry*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry*; D014363:Tryptamines
D016861:Cyclooxygenase Inhibitors; D005473:Fluoxetine; D007052:Ibuprofen; D023303:Oxazolidinones; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors; D014363:Tryptamines; C089750:zolmitriptan