Insulin/IGF signalling and ageing: seeing the bigger picture.
Although the underlying mechanisms of ageing are not understood, it is known that the longevity of the nematode Caenorhabditis elegans is modulated by an insulin/IGF-signalling pathway. The focus now is on how this pathway is regulated, how it controls nematode ageing, and how this relates to the ageing process in higher animals.
Gems
D
D
Department of Biology, University College London, 4 Stephenson Way, NW1 2HE, London, UK. david.gems@ucl.ac.uk
Partridge
L
L
D000375:Aging / Q000378:metabolism* / Q000502:physiology; D000818:Animals; D017173:Caenorhabditis elegans / Q000502:physiology; D004331:Drosophila melanogaster / Q000502:physiology; D002149:Energy Intake; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D051379:Mice; D015398:Signal Transduction / Q000502:physiology*; D013002:Somatomedins / Q000378:metabolism*
D007328:Insulin; D013002:Somatomedins