K:Cl cotransport activity is inhibited by HCO3- in knockout mouse red cells expressing human HbC.
K:Cl cotransport (KCl) was examined in transgenic mice expressing exclusively human hemoglobin C. In contrast to previous studies in early transgenic mice expressing human alpha and beta(S) and residual mouse globins, we found significant volume and pH stimulation and sensitivity to. Exposure to physiological levels of also blocked a significant fraction of KCl cotransport.
Romero
J R
JR
Endocrine-Hypertension Division, Brigham & Women's Hospital, Boston, Massachusetts 02115, USA.
Suzuka
S M
SM
Romero-González
G V
GV
Nagel
R L
RL
Fabry
M E
ME
D000818:Animals; D001639:Bicarbonates / Q000494:pharmacology*; D002352:Carrier Proteins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism* / Q000473:pathology; D006444:Hemoglobin C / Q000096:biosynthesis*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D023421:Models, Animal; D027981:Symporters; D000096922:K Cl- Cotransporters
D001639:Bicarbonates; D002352:Carrier Proteins; D006444:Hemoglobin C; D027981:Symporters; D000096922:K Cl- Cotransporters