Catechol derivatives of aminopyrazine and cell protection against UVB-induced mortality.
A series of 5-aryl- and 3,5-bis-aryl-2-amino-1,4-pyrazine derivatives 4 and 6, and related imidazolopyrazinones 7, has been synthesized, the aryl groups of which are catechol and/or phenol substituents. These compounds, tested against human keratinocyte cells stressed by UVB irradiation, showed high antioxidative properties. One compound (6f) was more active than EGCG/ECG (green tea extract) in reducing cell mortality.
Cavalier
J F
JF
Unité de Chimie Organique et Médicinale, Université catholique de Louvain, Bâtiment Lavoisier, Louvain-la-Neuve, Belgium.
Burton
M
M
Dussart
F
F
Marchand
C
C
Rees
J F
JF
Marchand-Brynaert
J
J
D000975:Antioxidants / Q000138:chemical synthesis / Q000494:pharmacology; D002396:Catechols / Q000138:chemical synthesis* / Q000494:pharmacology*; D002460:Cell Line; D003470:Culture Media; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D014466:Ultraviolet Rays
D000975:Antioxidants; D002396:Catechols; D003470:Culture Media; D011719:Pyrazines; D011837:Radiation-Protective Agents; D009243:NAD; C079424:2-aminopyrazine; D007770:L-Lactate Dehydrogenase