Mitochondrial DNA metabolism targeting drugs.
Numerous drugs are known to deplete mitochondrial DNA (mtDNA) from mammalian cells. These include DNA polymerase gamma and type II topoisomerase inhibitors, lipophilic cationic compounds, and DNA intercalating and non intercalating agents. The effects of these drugs on mtDNA metabolism will be discussed and potential mechanisms underlying their depletion of mtDNA presented.
Rowe
T C
TC
Department of Pharmacology and Therapeutics, University of Florida College of Medicine, Gainesville, FL 32610-0267, USA. tomrowe@ufl.edu
Weissig
V
V
Lawrence
J W
JW
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000737:chemistry; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000737:chemistry; D000074002:DNA Polymerase gamma; D004264:DNA Topoisomerases, Type I / Q000378:metabolism; D004272:DNA, Mitochondrial / Q000187:drug effects* / Q000378:metabolism; D004259:DNA-Directed DNA Polymerase; D003868:Dequalinium / Q000008:administration & dosage / Q000737:chemistry; D016503:Drug Delivery Systems / Q000379:methods*; D024841:Fluoroquinolones; D006801:Humans; D007364:Intercalating Agents / Q000008:administration & dosage / Q000737:chemistry; D019384:Nucleic Acid Synthesis Inhibitors; D010085:Oxidative Phosphorylation / Q000187:drug effects; D018894:Reverse Transcriptase Inhibitors / Q000008:administration & dosage / Q000737:chemistry; D059004:Topoisomerase I Inhibitors
D000890:Anti-Infective Agents; D000891:Anti-Infective Agents, Local; D004272:DNA, Mitochondrial; D024841:Fluoroquinolones; D007364:Intercalating Agents; D019384:Nucleic Acid Synthesis Inhibitors; D018894:Reverse Transcriptase Inhibitors; D059004:Topoisomerase I Inhibitors; D003868:Dequalinium; D000074002:DNA Polymerase gamma; D004259:DNA-Directed DNA Polymerase; D004264:DNA Topoisomerases, Type I