The presence of v-abl-transformed V3 mast cells in the lungs augments pulmonary vascular permeability to acid aspiration.
Acid aspiration causes pulmonary vascular permeability and PMN sequestration. By increasing pulmonary mast cells through adoptive transfer of v-abl-transformed mast cells (V3MCs) into BALB/c mice, we now show that the greater mast cell number in the lung is associated with increased pulmonary injury.
Mukundan
C
C
Department of Surgery, Harvard Medical School, Boston, Massachusetts, USA.
Gurish
M F
MF
Austen
K F
KF
Hechtman
H B
HB
Friend
D S
DS
D019264:Adoptive Transfer; D000818:Animals; D015824:Blood-Air Barrier; D004195:Disease Models, Animal; D008297:Male; D008407:Mast Cells / Q000473:pathology*; D008415:Mastocytosis; D051379:Mice; D008807:Mice, Inbred BALB C; D016374:Oncogene Proteins v-abl / Q000235:genetics / Q000302:isolation & purification; D011015:Pneumonia, Aspiration / Q000209:etiology* / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000473:pathology*
D016374:Oncogene Proteins v-abl