title: Serum melanotransferrin, p97 as a biochemical marker of Alzheimer's disease.
abstract: The protein melanotransferrin (p97) is associated with the brain lesions of Alzheimer's disease (AD) and is a potential marker of the disorder. We measured serum p97 concentrations in 211 subjects: 71 patients with AD, 56 patients with non-AD-type dementia, and 84 normal control subjects. Serum p97 concentrations were elevated 3- to 4-fold in AD (median 15.00 pg/microl, interquartile range 10.20-17.00 pg/microl) as compared to non AD dementia (2.85 pg/microl, 1.93-7.15 pg/microl) and normal controls (3.20 pg/microl, 2.55-3.95 pg/microl). The mean elevation was significant at 13.54 +/- 3.72 pg/microl, even in the 38 subjects with mild AD (CDR stage 0.5-1). Receiver operating characteristic analyses confirmed an optimal diagnostic threshold of 10.0 pg/microl, which yielded over-all accuracy of 0.882 to 0.915. Serum p97 is a candidate marker of AD, even in the early stage when clinical diagnosis is most uncertain.
authors.affiliation: Departments of Neuropsychiatry, Seoul, South Korea
authors.forename: D K
authors.initials: DK
authors.lastname: Kim
authors.forename: M Y
authors.initials: MY
authors.lastname: Seo
authors.forename: S W
authors.initials: SW
authors.lastname: Lim
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: J W
authors.initials: JW
authors.lastname: Kim
authors.forename: B J
authors.initials: BJ
authors.lastname: Carroll
authors.forename: D Y
authors.initials: DY
authors.lastname: Kwon
authors.forename: T
authors.initials: T
authors.lastname: Kwon
authors.forename: S S
authors.initials: SS
authors.lastname: Kang
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood* / Q000503:physiopathology; D000951:Antigens, Neoplasm; D001057:Apolipoproteins E / Q000235:genetics; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D018450:Disease Progression; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism; D008297:Male; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins / Q000097:blood*; D058225:Plaque, Amyloid / Q000378:metabolism; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D014407:Tumor Cells, Cultured
chemical_list: D000951:Antigens, Neoplasm; D001057:Apolipoproteins E; D015415:Biomarkers; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D007501:Iron