A histomorphometric and biomechanical study of the effect of delayed titanium implant placement in irradiated rabbit bone.
BACKGROUND
The time interval from irradiation to implant surgery has been considered an impact factor for implant integration in irradiated bone and the importance of a long interval between the radiation trauma and reconstructive bone surgery has been suggested.


OBJECTIVE
The present study was undertaken to histomorphometrically and biomechanically analyze the effect of delayed implant placement on bone healing around titanium implants in irradiated bone.


METHODS
Rabbits were given a single dose of 15 Gy Cobalt60 radiation to one hind leg, the other hind leg serving as a control. Titanium screws were inserted into the femur and tibia directly and at 12 weeks and 52 weeks after irradiation. The implants were evaluated after a healing time of 8 weeks. The torques necessary for removal of the implants were measured. Histomorphometry with respect to bone-metal contact and amount of bone surrounding the implants was performed.


RESULTS
The biomechanical force necessary to unscrew the titanium implants in the irradiated bone was significantly increased after a resting period of 1 year between irradiation and implant placement, compared to direct implant placement. The histomorphometric evaluation showed an improvement of bone healing around the implants in the irradiated bone, both after a resting period of 12 weeks and after 1 year compared to direct implant placement.


CONCLUSIONS
It is concluded that a relatively long interval between irradiation and reconstructive bone surgery will improve osseointegration of titanium implants in irradiated rabbit bone.
Johnsson
A A
AA
Department of Radiology, Sahlgrenska University Hospital, Göteborg University, Göteborg, Sweden.
Sawaii
T
T
Jacobsson
M
M
Granström
G
G
Turesson
I
I
D000818:Animals; D001696:Biomechanical Phenomena; D001842:Bone and Bones / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects* / Q000601:surgery; D003037:Cobalt Radioisotopes; D015921:Dental Implants; D005269:Femur / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects / Q000601:surgery; D005500:Follow-Up Studies; D016348:Osseointegration; D011817:Rabbits; D019275:Radiopharmaceuticals; D013223:Statistics as Topic; D018709:Statistics, Nonparametric; D013314:Stress, Mechanical; D013499:Surface Properties; D013977:Tibia / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects / Q000601:surgery; D013997:Time Factors; D014025:Titanium; D019415:Torque; D014945:Wound Healing
D003037:Cobalt Radioisotopes; D015921:Dental Implants; D019275:Radiopharmaceuticals; D014025:Titanium