title: [Vaccination and infection protection in patients with acquired or congenital immunodeficiency].
abstract: INDICATIONS FOR VACCINATIONS IN IMMUNODEPRESSED PATIENTS: The indication for vaccination depends on the demonstration of their efficacy and tolerance. Few studies have demonstrated a clinical benefit in this heterogeneous population and generally have enrolled splenectomized patients.
  Basically, the efficacy of vaccination is assessed from the post-vaccinal immune response which is generally altered in immunodepressed patients. This is specifically demonstrated for polysaccharide anti-pneumococcal vaccine. Thus, classical vaccinations with minimal immunogenic power that do not induce a memory response are not particularly effective for these patients. Indications are very controversial.
  
  
  CONCLUSIONS
  Recently developed conjugated vaccines (anti-haemophilus, anti-pneumococcal vaccines) are more immunogenic and offer interesting perspectives for new vaccination strategies in immunodepressed patients with a major risk of severe infection or infection caused by resistant strains.
authors.affiliation: Service d'Immunologie clinique, Hôpital Henri Mondor, 51, avenue du Maréchal de Lattre de Tassigny, F 94010 Créteil. clinic.immunol@hmn.ap.hp-hop.paris.fr
authors.forename: P
authors.initials: P
authors.lastname: Lesprit
mesh_terms: D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications* / Q000151:congenital; D011008:Pneumococcal Infections / Q000209:etiology / Q000517:prevention & control*; D022242:Pneumococcal Vaccines; D014765:Viral Vaccines; D014777:Virus Diseases / Q000209:etiology / Q000517:prevention & control*
chemical_list: D022242:Pneumococcal Vaccines; D014765:Viral Vaccines