Genetics of allergic disease.
Atopy can express itself as asthma, rhinitis and eczema. The presence of atopy can be assessed by increased levels of total serum IgE and specific IgE to common allergens, skin test positivity and increased numbers of peripheral blood eosinophils. Genetic studies indicate that multiple genes are involved in the pathogenesis of atopy and that different genes regulate the presence of increased levels of serum total IgE and specific IgE. Linkage of these traits to chromosomal regions likely to contain atopic susceptibility genes has been replicated in several studies. Genome-wide screens have identified several new chromosomal locations that are likely to contain atopic genes. These regions also contain candidate genes. Moreover, the available literature suggests that multiple, yet different genes may be involved in the translation of atopy to a distinct clinical phenotype. We anticipate that understanding of the genetic basis of atopy will lead to new therapeutic interventions and early diagnosis.
Feijen
M
M
Department of Pulmonary Rehabilitation, Beatrixoord Rehabilitation Centre, Haren, The Netherlands.
Gerritsen
J
J
Postma
D S
DS
D000485:Allergens / Q000276:immunology; D001094:Arachidonate 5-Lipoxygenase / Q000235:genetics; D001249:Asthma / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology; D002874:Chromosome Mapping; D016207:Cytokines / Q000235:genetics; D003876:Dermatitis, Atopic / Q000235:genetics; D005192:Family Health; D006801:Humans; D006967:Hypersensitivity / Q000235:genetics* / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology; D018950:Lipopolysaccharide Receptors / Q000235:genetics; D018343:Receptors, Adrenergic, beta-2 / Q000235:genetics; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology; D018433:Twin Studies as Topic
D000485:Allergens; D016207:Cytokines; D018950:Lipopolysaccharide Receptors; D018343:Receptors, Adrenergic, beta-2; D007073:Immunoglobulin E; D001094:Arachidonate 5-Lipoxygenase