[Correlation between liver fibrosis stage and serum liver fibrosis markers in patients with chronic hepatitis B].
OBJECTIVE
To evaluate the diagnostic value of serum liver fibrosis markers by analyzing the correlation between liver fibrosis stage in patients with chronic hepatitis B and serum liver fibrosis markers, such as hyaluronate, type III procollagen, laminin, and type IV collagen.


METHODS
There were 278 patients with chronic hepatitis B in this series. Before liver biopsy, the serum was collected to test hyaluronate, type III procollagen, laminin, and type IV collagen. Data were analyzed statistically.


RESULTS
Liver fibrosis stage was correlated to inflammation degree. In patients with moderate or serious liver inflammation and fibrosis, serum hyaluronate was above normal level, and correlated to liver inflammation and fibrosis. For patients with chronic hepatitis B, serum type III procollagen, laminin, and type IV collagen increased apparently. While laminin was correlated to liver fibrosis, type III procollagen and type IV collagen correlated to liver inflammation.


CONCLUSIONS
Serum hyaluronate, type III procollagen, laminin, and type IV collagen could reflect the state of liver fibrosis. Hyaluronate may be a useful marker for liver cirrhosis.
Ding
H
H
Department of Infectious Diseases, Nanfang Hospital of First Military Medical University, Guangzhou 510515, China.
Chen
Y
Y
Feng
X
X
Liu
D
D
Wu
A
A
Zhang
L
L
D000293:Adolescent; D000328:Adult; D002648:Child; D003094:Collagen / Q000097:blood; D005260:Female; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000473:pathology; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D007797:Laminin / Q000097:blood; D008099:Liver / Q000473:pathology; D008103:Liver Cirrhosis / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011347:Procollagen / Q000097:blood
D007797:Laminin; D011347:Procollagen; D006820:Hyaluronic Acid; D003094:Collagen