Hemopoietic cell kinetics after intraperitoneal single injection of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice.
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widely spread environmental pollutant. Homopoietic system is one of the targets of TCDD in laboratory animals including monkeys. The present study is the hemopoietic cell kinetics in mice, from the severe depression in cellularity of bone marrow and CFU-GM, to their recovery after the intraperitoneal injection of high dosage of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD). The bone-marrow cellularity and CFU-GM were severely decreased to 37.8% and 48% of the control, respectively until day 1 after exposure to TCDD. They were, however, soon recovered, even overshot the control value. Subsequently, they tended to show decrease and oscillation again to and under the control value. In conclusion, our cell kinetic study has proven the oscillation in bone-marrow cellularity and CFU-GM during the recovery period, of which the observation seems to be useful to extend our understanding in the hematotoxicity of TCDD.
Yoon
B I
BI
National Institute of Health Sciences, Biological Safety Research Center, Cellular and Molecular Toxicology Division, Tokyo, Japan.
Hirabayashi
Y
Y
Ogawa
Y
Y
Kanno
J
J
Inoue
T
T
Kaneko
T
T
D000818:Animals; D017209:Apoptosis; D001854:Bone Marrow Cells / Q000187:drug effects* / Q000473:pathology; D004785:Environmental Pollutants / Q000633:toxicity*; D006412:Hematopoietic Stem Cells; D007274:Injections, Intraperitoneal; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*
D004785:Environmental Pollutants; D000072317:Polychlorinated Dibenzodioxins