title: Arylsulphonyl hydroxamic acids: potent and selective matrix metalloproteinase inhibitors.
abstract: A series of novel matrix metalloproteinase inhibitors is described in which selectivity between MMP and 'sheddase' activity has been achieved and which demonstrate potent in vivo activity in models of arthritis and cancer.
authors.affiliation: Celltech Chiroscience Ltd, Granta Park, Cambridge CB1 6GS, Abington, UK.
authors.forename: A D
authors.initials: AD
authors.lastname: Baxter
authors.forename: R
authors.initials: R
authors.lastname: Bhogal
authors.forename: J
authors.initials: J
authors.lastname: Bird
authors.forename: J F
authors.initials: JF
authors.lastname: Keily
authors.forename: D T
authors.initials: DT
authors.lastname: Manallack
authors.forename: J G
authors.initials: JG
authors.lastname: Montana
authors.forename: D A
authors.initials: DA
authors.lastname: Owen
authors.forename: W R
authors.initials: WR
authors.lastname: Pitt
authors.forename: R J
authors.initials: RJ
authors.lastname: Watson
authors.forename: R E
authors.initials: RE
authors.lastname: Wills
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D004195:Disease Models, Animal; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006877:Hydroxamic Acids / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D061965:Matrix Metalloproteinase Inhibitors; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D006877:Hydroxamic Acids; D061965:Matrix Metalloproteinase Inhibitors; C100342:marimastat