Vaccination against leprosy at Ben San Leprosy Centre, Ho Chi Minh City, Vietnam.
Three vaccines, BCG alone, BCG + 10(7) killed Mycobacterium vaccae and 10(8) killed M. vaccae alone, were studied in children living in close contact with leprosy. In the year before vaccination, 14/446 (3.1%) children had developed leprosy. Among those who were not vaccinated, 9/74 (12.2%) developed the disease in the first 4 years of the study and 5/65 (7.7%) developed the disease in the second 4 years. In comparison with this, among those vaccinated, 20/343 (5.8%) developed leprosy in the first 4 years and 5/323 (1.5%) developed leprosy in the second 4 years. This represents 52.5% protection in the first 4 years and 80.5% in the second 4 years. There were no significant differences in protection afforded by each of the three vaccines but the success of the killed preparation of M. vaccae is an important finding.
Truoc
L V
LV
Ben San Leprosy Centre, Ho Chi Minh City, Viet Nam.
Ly
H M
HM
Thuy
N K
NK
Trach
D D
DD
Stanford
C A
CA
Stanford
J L
JL
D000293:Adolescent; D000328:Adult; D001500:BCG Vaccine / Q000494:pharmacology*; D001428:Bacterial Vaccines / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007115:Immunization Schedule; D007918:Leprosy / Q000453:epidemiology / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission; D008297:Male; D009161:Mycobacterium / Q000276:immunology; D012882:Skin Tests; D013997:Time Factors; D015164:Vaccines, Inactivated / Q000494:pharmacology; D014744:Vietnam / Q000453:epidemiology
D001500:BCG Vaccine; D001428:Bacterial Vaccines; D015164:Vaccines, Inactivated