title: In vitro activities of ertapenem (MK-0826) against clinical bacterial isolates from 11 North American medical centers.
abstract: This study compared the in vitro activities of the new long-half-life carbapenem ertapenem (also known as MK-0826 and L-749,345) with those of imipenem, amoxicillin-clavulanate, and ciprofloxacin against 5,558 recent clinical isolates from 11 North American medical centers. We confirmed the greater activity of ertapenem than of imipenem against the Enterobacteriaceae and the greater activity of imipenem against pseudomonads and gram-positive bacteria.
authors.affiliation: The Clinical Microbiology Institute, Wilsonville, Oregon 97070, USA. cmi@hevanet.com
authors.forename: P C
authors.initials: PC
authors.lastname: Fuchs
authors.forename: A L
authors.initials: AL
authors.lastname: Barry
authors.forename: S D
authors.initials: SD
authors.lastname: Brown
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015780:Carbapenems / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009656:North America
chemical_list: D000900:Anti-Bacterial Agents; D015780:Carbapenems; C108047:L 749345