title: NAC/MEA conjugate: a new potent antioxidant which increases the GSH level in various cell lines.
abstract: I-152 is a prodrug of NAC and MEA with potent pro-GSH effects in human macrophages, astrocytes and lymphocytes. This molecule could be of interest in HIV infection in respect to its antioxidant and anti-HIV activities, but also in other diseases to counteract oxidative stress, that is, inflammation, cardiovascular diseases, and neurodegenerative diseases.
authors.affiliation: Laboratoire de Chimie Organique Biomoléculaire de Synthèse, UMR 5625 CNRS-UM II, Université Montpellier II, Sciences et Techniques du Languedoc, France. oiryj@univ-montp2.fr
authors.forename: J
authors.initials: J
authors.lastname: Oiry
authors.forename: P
authors.initials: P
authors.lastname: Mialocq
authors.forename: J Y
authors.initials: JY
authors.lastname: Puy
authors.forename: P
authors.initials: P
authors.lastname: Fretier
authors.forename: P
authors.initials: P
authors.lastname: Clayette
authors.forename: D
authors.initials: D
authors.lastname: Dormont
authors.forename: J L
authors.initials: JL
authors.lastname: Imbach
mesh_terms: D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D000975:Antioxidants / Q000138:chemical synthesis* / Q000494:pharmacology*; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000378:metabolism; D002460:Cell Line; D003543:Cysteamine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism*; D015658:HIV Infections / Q000378:metabolism; D006801:Humans; D007202:Indicators and Reagents; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D011355:Prodrugs / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; C436346:I-152 compound; D007202:Indicators and Reagents; D011355:Prodrugs; D003543:Cysteamine; D005978:Glutathione; D000111:Acetylcysteine