Alternative binding assay of GP IIb/IIIa antagonists with a nonradioactive labeling method of platelets.
Alfón
J
J
Department of Pharmacology and Toxicology, Research Centre, J. Uriach & Cía. S.A., Degà Bahí 59, 08026, Barcelona, Spain. pharm-alfon@uriach.com
Fernández de Arriba
A
A
Gómez-Casajús
L A
LA
Merlos
M
M
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D005452:Fluoresceins; D005456:Fluorescent Dyes; D006801:Humans; D020128:Inhibitory Concentration 50; D008722:Methods; D015539:Platelet Activation / Q000187:drug effects; D010973:Platelet Adhesiveness / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000032:analysis* / Q000737:chemistry; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D011485:Protein Binding; D013050:Spectrometry, Fluorescence
D005452:Fluoresceins; D005456:Fluorescent Dyes; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; C085925:calcein AM; D000244:Adenosine Diphosphate; D005340:Fibrinogen