title: The efficacy of fluoxetine in improving physical symptoms associated with premenstrual dysphoric disorder.
abstract: OBJECTIVE
  To determine the effectiveness of fluoxetine in alleviating physical symptoms of premenstrual dysphoric disorder.
  
  
  METHODS
  Randomised, double-blind, placebo controlled, parallel study.
  
  
  METHODS
  Canadian University based outpatient clinics. Participants Four hundred and five subjects, of whom 320 with prospectively determined premenstrual dysphoric disorder were randomised.
  
  
  METHODS
  Randomised women were assigned to fluoxetine 20 or 60 mg/day or placebo. Common physical symptoms associated with premenstrual dysphoric disorder including breast tenderness, bloating, and headache were evaluated by visual analog scales and the self-rated and observer premenstrual tension syndrome scales.
  
  
  METHODS
  Luteal phase change from mean baseline scores to mean treatment scores for all scales.
  
  
  RESULTS
  Fluoxetine treatment was statistically superior to placebo, with no significant differences between the two fluoxetine dosages in their effects on physical symptoms.
  
  
  CONCLUSIONS
  Daily fluoxetine treatment is superior to placebo in improving the most common physical symptoms associated with premenstrual dysphoric disorder.
authors.affiliation: McMaster University, St. Joseph's Hospital, Hamilton, Ontario, Canada.
authors.forename: M
authors.initials: M
authors.lastname: Steiner
authors.forename: S J
authors.initials: SJ
authors.lastname: Romano
authors.forename: S
authors.initials: S
authors.lastname: Babcock
authors.forename: J
authors.initials: J
authors.lastname: Dillon
authors.forename: C
authors.initials: C
authors.lastname: Shuler
authors.forename: C
authors.initials: C
authors.lastname: Berger
authors.forename: D
authors.initials: D
authors.lastname: Carter
authors.forename: R
authors.initials: R
authors.lastname: Reid
authors.forename: D
authors.initials: D
authors.lastname: Stewart
authors.forename: S
authors.initials: S
authors.lastname: Steinberg
authors.forename: R
authors.initials: R
authors.lastname: Judge
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage*; D006801:Humans; D011293:Premenstrual Syndrome / Q000188:drug therapy*; D017367:Selective Serotonin Reuptake Inhibitors / Q000008:administration & dosage*; D016896:Treatment Outcome
chemical_list: D005473:Fluoxetine; D017367:Selective Serotonin Reuptake Inhibitors