Mitochondrial polypeptides of the oxidative phosphorylation pathway as potential new targets for anti-cancer therapy.
We have analyzed our own results on upregulated gene expression in human and monkey lymphomas as well as the data published on expression levels of genes in various cancer cells. The analysis suggests an important role of particular subunits of oxidative phosphorylation (OXPHOS) proteins in malignant transformation of the cell. It opens a possibility of designing new anti-cancer drugs aimed at specific inhibition of the expression of definite mitochondrial OXPHOS proteins' subunits including those of NADH-dehydrogenase 4, cytochrome c oxidase 1, and cytochrome b.
Tarantul
V Z
VZ
Department of Viral and Cellular Molecular Genetics, Institute of Molecular Genetics, Moscow, Russia. tarantul@img.ras.ru
Hunsmann
G
G
D000818:Animals; D003573:Cytochrome b Group / Q000378:metabolism; D015195:Drug Design; D003576:Electron Transport Complex IV / Q000378:metabolism; D015972:Gene Expression Regulation, Neoplastic; D000882:Haplorhini; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy / Q000235:genetics; D008928:Mitochondria / Q000378:metabolism*; D025261:Mitochondrial Proton-Translocating ATPases; D008954:Models, Biological; D009245:NADH Dehydrogenase / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000235:genetics*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D021122:Protein Subunits; D006180:Proton-Translocating ATPases / Q000378:metabolism
D003573:Cytochrome b Group; D021122:Protein Subunits; D009245:NADH Dehydrogenase; D003576:Electron Transport Complex IV; C412204:ATP synthase subunit 6; D025261:Mitochondrial Proton-Translocating ATPases; D006180:Proton-Translocating ATPases