title: A new Antennapedia-derived vector for intracellular delivery of exogenous compounds.
abstract: We describe the design, synthesis and cell translocation capacity of a peptide derived from the third alpha-helix of the homeodomain of Antennapedia. The new sequence appears to be an efficient and nontoxic means to deliver a covalently linked peptide cargo into cells.
authors.affiliation: Oncology Research, Novartis Pharma Inc., CH-4002, Basel, Switzerland. carlos.garcia-echeverria@pharma.novartis.com
authors.forename: C
authors.initials: C
authors.lastname: García-Echeverría
authors.forename: L
authors.initials: L
authors.lastname: Jiang
authors.forename: T M
authors.initials: TM
authors.lastname: Ramsey
authors.forename: S K
authors.initials: SK
authors.lastname: Sharma
authors.forename: Y P
authors.initials: YP
authors.lastname: Chen
mesh_terms: D051943:Antennapedia Homeodomain Protein; D004337:Drug Carriers; D016503:Drug Delivery Systems; D015195:Drug Design; D018398:Homeodomain Proteins / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D014157:Transcription Factors; D014407:Tumor Cells, Cultured
chemical_list: D051943:Antennapedia Homeodomain Protein; D004337:Drug Carriers; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D010455:Peptides; D014157:Transcription Factors