[Cardiac sarcoidosis].
A cardiac localization is one of the most severe manifestations of sarcoidosis and may cause sudden death (ventricular tachycardia or atrial ventricular block III) or restrictive cardiomyopathy. Lesions are most frequently observed in the interventricular septum and the free left wall. Granulomatous infiltation can provoke nonspecific clinical, electric and echocardiographic signs, which, associated with regressive dipyridamol uptake on tomoscintigraphy, are suggestive of cardiac sarcoidosis. The diagnosis of cardiac sarcoidosis is based on the presence of systemic sarcoidosis, histological evidence of granuloma and the lack of another cause of cardiomyopathy. Corticosteroid therapy is indicated, associated with specific cardiologic treatments.
Chapelon-Abric
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Service de Médecine Interne, CHU Pitié-Salpêtrière, 47-83, boulevard de l'Hôpital, 75651 Paris Cedex 13.
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D001706:Biopsy; D009202:Cardiomyopathies / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000453:epidemiology; D002313:Cardiomyopathy, Restrictive / Q000209:etiology; D002317:Cardiovascular Agents / Q000627:therapeutic use; D016757:Death, Sudden, Cardiac / Q000209:etiology; D004176:Dipyridamole; D004452:Echocardiography; D004562:Electrocardiography; D006327:Heart Block / Q000209:etiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D012507:Sarcoidosis / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy* / Q000453:epidemiology; D013256:Steroids; D017180:Tachycardia, Ventricular / Q000209:etiology; D014665:Vasodilator Agents
D000893:Anti-Inflammatory Agents; D002317:Cardiovascular Agents; D007166:Immunosuppressive Agents; D013256:Steroids; D014665:Vasodilator Agents; D004176:Dipyridamole