title: Noninvasive assessment of pulmonary arterial hypertension by MR phase-mapping method.
abstract: We describe a magnetic resonance (MR) imaging method that emphasizes pressure wave velocity to noninvasively assess pulmonary arterial hypertension. Both the blood flow and the corresponding vessel cross-sectional area (CSA) were measured by MR phase mapping in the main pulmonary artery (MPA) in 15 patients. MPA pressures were also measured, in the same patients, by right-side heart catheterization. Two significant relationships were established: 1) between the pressure wave velocity in the MPA and the mean pressure in the MPA (Ppa) writing pressure wave velocity = 9.25 Ppa - 202.51 (r = 0.82) and 2) between the ratio of pressure wave velocity to the systolic blood velocity peak in the MPA (R) and the mean pressure in the MPA writing R = 0.68 Ppa - 4.33 (r = 0.89). Using these relationships, we estimated two pressure values to frame the actual Ppa value in each patient from the present series with a reasonable reliability percentage (87%).
authors.affiliation: Service de Médecine Nucléaire, Hôpital du Haut-Lévêque, 33604 Pessac, France. elaffon@u-bordeaux2.fr
authors.forename: E
authors.initials: E
authors.lastname: Laffon
authors.forename: F
authors.initials: F
authors.lastname: Laurent
authors.forename: V
authors.initials: V
authors.lastname: Bernard
authors.forename: L
authors.initials: L
authors.lastname: De Boucaud
authors.forename: D
authors.initials: D
authors.lastname: Ducassou
authors.forename: R
authors.initials: R
authors.lastname: Marthan
mesh_terms: D000328:Adult; D000368:Aged; D000399:Air Pressure; D000465:Algorithms; D006328:Cardiac Catheterization; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000175:diagnosis* / Q000503:physiopathology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011652:Pulmonary Circulation / Q000502:physiology