title: Inhibitors of the bacterial cell wall biosynthesis enzyme MurC.
abstract: A series of phosphinate transition-state analogues of the L-alanine adding enzyme (MurC) of bacterial peptidoglycan biosynthesis was prepared and tested as inhibitors of the Escherichia coli enzyme. Compound 4 was identified as a potent inhibitor of MurC from Escherichia coli with an IC(50) of 49nM.
authors.affiliation: Chemistry, Infection Discovery, AstraZeneca R&D Boston, 35 Gatehouse Drive, Waltham, MA 02451, USA.
authors.forename: F
authors.initials: F
authors.lastname: Reck
authors.forename: S
authors.initials: S
authors.lastname: Marmor
authors.forename: S
authors.initials: S
authors.lastname: Fisher
authors.forename: M A
authors.initials: MA
authors.lastname: Wuonola
mesh_terms: D002473:Cell Wall / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D010453:Peptide Synthases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D010457:Peptidoglycan / Q000378:metabolism
chemical_list: D004791:Enzyme Inhibitors; D010457:Peptidoglycan; D010453:Peptide Synthases; C023229:UDP-N-acetylmuramoyl-alanine synthetase