title: Parkinson's disease is not associated with the combined alpha-synuclein/apolipoprotein E susceptibility genotype.
abstract: A recent study showed significant association of sporadic Parkinson's disease with a polymorphism within the alpha-synuclein gene and closely linked DNA markers on chromosome 4q and the APOE epsilon4 allele. A combined alpha-synuclein/APOE-epsilon4 genotype increased the relative risk of developing Parkinson's disease 12-fold. We failed to confirm this association in a much larger sample of histopathologically proven cases of Parkinson's disease and controls.
authors.affiliation: Neurogenetics Section, Institute of Neurology, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Khan
authors.forename: E
authors.initials: E
authors.lastname: Graham
authors.forename: P
authors.initials: P
authors.lastname: Dixon
authors.forename: C
authors.initials: C
authors.lastname: Morris
authors.forename: A
authors.initials: A
authors.lastname: Mander
authors.forename: D
authors.initials: D
authors.lastname: Clayton
authors.forename: J
authors.initials: J
authors.lastname: Vaughan
authors.forename: N
authors.initials: N
authors.lastname: Quinn
authors.forename: A
authors.initials: A
authors.lastname: Lees
authors.forename: S
authors.initials: S
authors.lastname: Daniel
authors.forename: N
authors.initials: N
authors.lastname: Wood
authors.forename: R
authors.initials: R
authors.lastname: de Silva
mesh_terms: D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics; D005260:Female; D005819:Genetic Markers / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000235:genetics*; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics; D051843:Synucleins; D051844:alpha-Synuclein
chemical_list: D001057:Apolipoproteins E; D005819:Genetic Markers; D009419:Nerve Tissue Proteins; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein