Cytogenetic investigation of women exposed to different levels of dioxins in Chapaevsk town.
Three groups of women (aged 20-40 years) exposed to different levels of dioxins were studied in Chapaevsk town: 15 women working at the chemical fertilizer plant where occupational exposure to dioxins is possible; 16 women without dioxins occupational exposure, but living as far as 1-3 km from the plant; 14 women without dioxins occupational exposure and living as far as 5-8 km from the plant. No personal correlation related to dioxins exposure was found by chromosome aberrations (CA) in peripheral blood lymphocytes, micronuclei (MN) and nuclear anomalies in buccal mucosa cells. There were no significant differences between the groups in CA and MN. Karyopyknosis and karyorrhexis were significantly increased in the highest exposed group.
Revazova
J
J
A.N. Sysin Institute of Human Ecology and Environmental Hygiene, Russian Academy of Medical Sciences, Moscow, Russian Federation. revazova@cityline.ru
Yurchenko
V
V
Katosova
L
L
Platonova
V
V
Sycheva
L
L
Khripach
L
L
Ingel
F
F
Tsutsman
T
T
Zhurkov
V
V
D000328:Adult; D002869:Chromosome Aberrations; D004147:Dioxins / Q000009:adverse effects*; D004781:Environmental Exposure; D005260:Female; D005308:Fertilizers; D006801:Humans; D007221:Industry; D009061:Mouth Mucosa; D016273:Occupational Exposure
D004147:Dioxins; D005308:Fertilizers