title: Naphthopyranone glycosides from Paepalanthus microphyllus.
abstract: Three new naphthopyranone glycosides, paepalantine-9-O-beta-D-glucopyranosyl-(1-->6)-beta-D-glucopyranoside (1), paepalantine-9-O-alpha-L-arabinopyranosyl-(1-->6)-beta-D-glucopyranoside (2), and paepalantine-9-O-alpha-L-rhamnopyranosyl-(1-->6)-beta-D-glucopyranoside (3), along with the known paepalantine-9-O-beta-D-glucopyranoside (4) were isolated from aerial parts of Paepalanthus microphyllus. These compounds were characterized by spectrometric methods, including electrospray mass spectrometry and 1D and 2D NMR experiments. As a part of our program for screening natural compounds for anti-HIV activity, compounds 1-4 were tested in C8166 cells infected with HIV-1MN.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università degli Studi di Salerno, Via Ponte Don Melillo 84084, Fisciano, SA, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Piacente
authors.forename: L
authors.initials: L
authors.lastname: Campaner Dos Santos
authors.forename: N
authors.initials: N
authors.lastname: Mahmood
authors.forename: A
authors.initials: A
authors.lastname: Zampelli
authors.forename: C
authors.initials: C
authors.lastname: Pizza
authors.forename: W
authors.initials: W
authors.lastname: Vilegas
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D001938:Brazil; D004353:Drug Evaluation, Preclinical; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D021241:Spectrometry, Mass, Electrospray Ionization; D013056:Spectrophotometry, Ultraviolet
chemical_list: D019380:Anti-HIV Agents; D006027:Glycosides