[Follow-up of differentiated thyroid cancer patients using rhTSH--preliminary results].
OBJECTIVE
In the follow-up of patients with advanced stage thyroid cancer radioiodine scintigraphy, F-18-FDG PET and tumormarker hTg using stimulation with recombinant human TSH (rhTSH) were compared to the results of same diagnostic procedures during TSH-suppression or endogenous TSH-stimulation.


METHODS
30 patients were investigated in hypothyroidism and after application of rhTSH regarding the serum hormone concentrations, hTg, radioiodine scans and FGD-PET scans.


RESULTS
Radioiodine avidity and FDG uptake were significantly higher in 7/30 and 3/5 patients, respectively, compared to endogenous stimulation or TSH-suppression. In about one third of patients hTg increased more than 30%.


CONCLUSIONS
Our preliminary results indicate a sufficient feasibility and sensitivity of rhTSH not only in the follow-up by hTg and radioiodine scan but also in FDG-PET.
Petrich
T
T
Klinik für Nuklearmedizin, Medizinische Hochschule Hannover, Deutschland.
Börner
A R
AR
Weckesser
E
E
Soudah
B
B
Otto
D
D
Widjaja
A
A
Hofmann
M
M
Kreipe
H H
HH
Knapp
W H
WH
D000328:Adult; D000368:Aged; D005240:Feasibility Studies; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D007457:Iodine Radioisotopes; D008875:Middle Aged; D009367:Neoplasm Staging; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D011994:Recombinant Proteins; D012680:Sensitivity and Specificity; D013954:Thyroglobulin / Q000097:blood; D013964:Thyroid Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy; D013972:Thyrotropin; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D011994:Recombinant Proteins; D014284:Triiodothyronine; D019788:Fluorodeoxyglucose F18; D013972:Thyrotropin; D013954:Thyroglobulin; D013974:Thyroxine