[Local anesthetics: part 153. Relation between the chemical structure, physico-chemical properties and biological activity in a series of piperidinopropylesters of alkoxy-substituted phenylcarbamic acids].
Physical-chemical parameters (surface tension, dissociation constant, RF and RM values determined by means of TLC, logarithm of the capacity factor by means of HPLC) of 30 compounds from the group of piperidinopropylesters of o-, m-, p-alkoxyphenylcarbamic acids with local-anaesthetic activity were determined. The correlation chemical structure--physical-chemical properties--local-anaesthetic activity was studied by means of QSAR. The results of the study have demonstrated a linear dependence between log k, RM, and the number of C in the alkoxysubstituent.
Sedlárová
E
E
Katedra farmaceutickej chémie Farmaceutickej fakulty Univerzity Komenského, Bratislava.
Cizmárik
J
J
D000779:Anesthetics, Local / Q000737:chemistry*; D002219:Carbamates / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D010880:Piperidines / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000779:Anesthetics, Local; D002219:Carbamates; D010880:Piperidines