title: Leptin and phospholipid-esterified docosahexaenoic acid concentrations in plasma of women: observations during pregnancy and lactation.
abstract: BACKGROUND
  The n-3 fatty acid status changes during pregnancy and lactation. Plasma leptin concentrations and gene expression have been related to n-3 fatty acids.
  
  
  OBJECTIVE
  To investigate the relation between plasma leptin concentration and the docosahexaenoic acid (22:6n-3) content of plasma phospholipids during early pregnancy and the postpartum period.
  
  
  METHODS
  Leptin (radioimmunoassay) and the phospholipid fatty acid profile (capillary gas-liquid chromatography) were measured in plasma of women during two independent longitudinal observational studies. Dietary intake of n-3 fatty acids was also determined.
  
  
  RESULTS
  Within the first 10 weeks after the last menstrual period, an almost parallel increase in leptin concentration and the 22:6n-3 content (mg/l and % wt/wt) of plasma phospholipids was seen (study 1, n = 21). During the postpartum period (study 2, n = 57), leptin levels decreased quickly, preceding the changes in 22:6n-3 concentrations. During both studies, leptin concentrations did not consistently relate to dietary intake of n-3 fatty acids or to 22:6n-3 concentrations in plasma phospholipids. Before and during early pregnancy (study 1), significant positive associations between leptin levels and the total amount of phospholipid-associated fatty acids were found. No such association was seen during late pregnancy or the postpartum period (study 2). The postpartum decrease in leptin levels did not differ between lactating and non-lactating women.
  
  
  CONCLUSIONS
  Not the 22:6n-3 content, but the total amount of phospholipid-associated fatty acids was related to plasma leptin concentration, before and during early pregnancy but not during late pregnancy and the postpartum period.
authors.affiliation: Nutrition and Toxicology Research Institute, Maastricht (NUTRIM), The Netherlands. p.rump@hb.unimaas.nl
authors.forename: P
authors.initials: P
authors.lastname: Rump
authors.forename: S J
authors.initials: SJ
authors.lastname: Otto
authors.forename: G
authors.initials: G
authors.lastname: Hornstra
mesh_terms: D015992:Body Mass Index; D001835:Body Weight; D004032:Diet; D004281:Docosahexaenoic Acids / Q000097:blood* / Q000737:chemistry; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage* / Q000097:blood; D005260:Female; D006801:Humans; D007774:Lactation / Q000097:blood*; D020738:Leptin / Q000097:blood*; D008137:Longitudinal Studies; D010743:Phospholipids / Q000097:blood / Q000737:chemistry; D049590:Postpartum Period / Q000097:blood; D011247:Pregnancy / Q000097:blood*; D011261:Pregnancy Trimester, First; D013997:Time Factors
chemical_list: D015525:Fatty Acids, Omega-3; D020738:Leptin; D010743:Phospholipids; D004281:Docosahexaenoic Acids