Coronary artery disease risk in Chinese type 2 diabetics: is there a role for paraxonase 1 gene (Q192R) polymorphism?
OBJECTIVE
Heredity plays an important role in the predisposition to atherosclerotic coronary artery disease (CAD), and its thrombotic complications. Paraoxonase, a high-density lipoprotein-associated enzyme capable of hydrolyzing lipid peroxides, is presumed to contribute to atherosclerosis and CAD. This study investigates the role of human paraoxonase 1 (PON 1) gene (Q192R) polymorphism in CAD risk among Chinese type 2 diabetic cases.


METHODS
A population-based case-control study of paraoxonase 1 gene (Q192R) polymorphism and the risk of CAD in Chinese type 2 diabetics.


METHODS
Subjects included 201 angiographically documented CAD patients with type 2 diabetes and 231 control subjects with type 2 diabetes alone living in central China. Single strand conformational polymorphism (SSCP) analysis was used to screen for PON 1 gene (Q192R) polymorphism.


RESULTS
Frequency of the R allele was 21.5% in the CAD patients and 12.0% in the control subjects. The presence of the R allele was significantly associated with risk of CAD (odds ratio (OR)=1.97; 95% confidence interval (CI)=1.36--2.86).


CONCLUSIONS
Frequency of the 192R allele of the human paraoxonase 1 gene may be an independent risk factor for CAD in the Chinese type 2 diabetics studied.
Osei-Hyiaman
D
D
Graduate School of Medicine, University of Tsukuba, Tsukuba City, Ibaraki-ken, Japan. shaddai@medscape.com
Hou
L
L
Mengbai
F
F
Zhiyin
R
R
Zhiming
Z
Z
Kano
K
K
D000368:Aged; D043303:Aryldialkylphosphatase; D002681:China; D003327:Coronary Disease / Q000453:epidemiology* / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000235:genetics; D004950:Esterases / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics*; D018807:Polymorphism, Single-Stranded Conformational; D012044:Regression Analysis; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors
D004950:Esterases; D043303:Aryldialkylphosphatase; C468406:PON1 protein, human