title: A novel and efficient methodology for the C-C bond forming radical cyclization of hydrophobic substrates in water.
abstract: [reaction: see text]. The combination of water-soluble radical initiator 2,2'-azobis[2-(2-imidazolin-2-yl)propane] (VA-061), water-soluble chain carrier 1-ethylpiperidine hypophosphite (EPHP), and surfactant cetyltrimethylammonium bromide (CTAB) was found to be the most suitable condition for effective radical cyclization in water for a variety of hydrophobic substrates.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, 1-6, Yamada-oka, Suita, Osaka 565-0871, Japan. kita@phs.osaka-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Kita
authors.forename: H
authors.initials: H
authors.lastname: Nambu
authors.forename: N G
authors.initials: NG
authors.lastname: Ramesh
authors.forename: G
authors.initials: G
authors.lastname: Anilkumar
authors.forename: M
authors.initials: M
authors.lastname: Matsugi
mesh_terms: D001391:Azo Compounds / Q000737:chemistry; D002244:Carbon / Q000737:chemistry*; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000737:chemistry; D005609:Free Radicals; D007093:Imidazoles / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010880:Piperidines / Q000737:chemistry; D013501:Surface-Active Agents / Q000494:pharmacology; D014867:Water / Q000737:chemistry*
chemical_list: D001391:Azo Compounds; D002593:Cetrimonium Compounds; D005609:Free Radicals; D007093:Imidazoles; D010880:Piperidines; D013501:Surface-Active Agents; C430118:VA 061; D014867:Water; D002244:Carbon; C430119:1-ethylpiperidine; D000077286:Cetrimonium