[Germ cell apoptosis and regulation in testis].
Both spontaneous and induced germ cell apoptosis occur during the process of germ cell differentiation in testis, which is an important mechanism to remove surplus and abnormal germ cells. It has been known that germ cell apoptosis is under the control of endocrine, cell social association and gene. To elucidate the molecular mechanisms by which germ cell apoptosis is regulated and the elements of the death machinery will provide a basis for effective management of male infertility as well as more targeted approaches to male contraception.
Guo
C X
CX
State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080.
Tang
T S
TS
Liu
Y X
YX
D000818:Animals; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D051786:Cyclic AMP Response Element Modulator; D004268:DNA-Binding Proteins / Q000235:genetics; D005786:Gene Expression Regulation; D005854:Germ Cells / Q000502:physiology*; D006062:Gonadotropins / Q000494:pharmacology; D006358:Hot Temperature; D008297:Male; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics; D051381:Rats; D012097:Repressor Proteins; D013091:Spermatogenesis / Q000235:genetics / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology; D016159:Tumor Suppressor Protein p53 / Q000235:genetics; D019014:fas Receptor / Q000235:genetics
D004268:DNA-Binding Proteins; D006062:Gonadotropins; D011518:Proto-Oncogene Proteins; D012097:Repressor Proteins; D016159:Tumor Suppressor Protein p53; D019014:fas Receptor; D051786:Cyclic AMP Response Element Modulator; D013739:Testosterone; D019009:Proto-Oncogene Proteins c-kit