title: A new unusual iridoid with inhibition of activator protein-1 (AP-1) from the leaves of Morinda citrifolia L.
abstract: [structure in text] From the leaves of Morinda citrifolia, a new unusual iridoid, named citrifolinoside (1), showing significant inhibition of UVB-induced Activator Protein-1 (AP-1) activity in cell cultures, has been isolated. Its structure was elucidated on the basis of detailed high-field 1D and 2D spectral analysis.
authors.affiliation: Department of Food Science and Center for Advanced Food Technology, Rutgers University, 65 Dudley Road, New Brunswick, New Jersey 08901-8520, USA. smsang@hotmail.com
authors.forename: S
authors.initials: S
authors.lastname: Sang
authors.forename: K
authors.initials: K
authors.lastname: He
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: N
authors.initials: N
authors.lastname: Zhu
authors.forename: X
authors.initials: X
authors.lastname: Cheng
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Zheng
authors.forename: Z
authors.initials: Z
authors.lastname: Dong
authors.forename: G
authors.initials: G
authors.lastname: Ghai
authors.forename: R T
authors.initials: RT
authors.lastname: Rosen
authors.forename: C T
authors.initials: CT
authors.lastname: Ho
mesh_terms: D005960:Glucosides / Q000302:isolation & purification / Q000494:pharmacology / Q000627:therapeutic use*; D057888:Iridoid Glucosides; D039823:Iridoids; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008517:Phytotherapy; D010946:Plants, Medicinal / Q000737:chemistry / Q000627:therapeutic use*; D019666:Rubiaceae / Q000737:chemistry / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013329:Structure-Activity Relationship; D018808:Transcription Factor AP-1 / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D018808:Transcription Factor AP-1; C428483:citrifolinoside