title: New methods of resolution and purification of racemic and diastereomeric amino alcohol derivatives using boric acid and chiral 1,1'-bi-2-naphthol.
abstract: Resolution of the racemic amino alcohol derivatives 1-6 is readily achieved to obtain enantiomerically enriched compounds using chiral 1,1'-bi-2-naphthol and boric acid in solvents such as CH(3)CN, THF, and MeOH. Purification of the diastereomeric mixture 7 has also been carried out following this method. The corresponding intermediate ammonium borate complexes were also characterized by X-ray diffraction methods.
authors.affiliation: School of Chemistry, University of Hyderabad, Central University P.O., Hyderabad 500 046, India. mpsc@uohyd.ernet.in
authors.forename: M
authors.initials: M
authors.lastname: Periasamy
authors.forename: N S
authors.initials: NS
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Sivakumar
authors.forename: V D
authors.initials: VD
authors.lastname: Rao
authors.forename: C R
authors.initials: CR
authors.lastname: Ramanathan
authors.forename: L
authors.initials: L
authors.lastname: Venkatraman