title: Determination of the activity of pyrantel tartrate against Sarcocystis neurona in gamma-interferon gene knockout mice.
abstract: Equine protozoal myeloencephalitis (EPM) is the most important protozoal disease of horses in the United States. Some horse owners and equine clinicians believe that horses which are on daily pyrantel tartrate at 2.64mg/kg for helminth prophylaxis are less likely to develop EPM. The present study examined the efficacy of pyrantel tartrate in preventing clinical disease in gamma-interferon gene knockout (BALB/c-Ifng(tm1ts)) mice. No activity was seen against sporocyst-induced Sarcocystis neurona infections in mice treated prophylacticly with 4-5mg pyrantel tartrate per mouse per day in the drinking water.
authors.affiliation: Center for Molecular Medicine and Infectious Diseases, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland Regional College of Veterinary Medicine, Virginia Tech, 1410 Prices Fork Road, Blacksburg, VA 24061-0342, USA. lindsayd@vt.edu
authors.forename: D S
authors.initials: DS
authors.lastname: Lindsay
authors.forename: J P
authors.initials: JP
authors.lastname: Dubey
mesh_terms: D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D001921:Brain / Q000469:parasitology; D004195:Disease Models, Animal; D007371:Interferon-gamma / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D011717:Pyrantel Tartrate / Q000627:therapeutic use*; D012522:Sarcocystis / Q000187:drug effects*; D012523:Sarcocystosis / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000969:Antinematodal Agents; D007371:Interferon-gamma; D011717:Pyrantel Tartrate