The molecular puzzle of two-component signaling cascades.
Two-component systems constitute prevalent signaling pathways in bacteria and mediate a large variety of adaptative cellular responses. Signaling proceeds through His-Asp phosphorelay cascades that involve two central partners, the histidine protein kinase and the response regulator protein. Structural studies have provided insights into some design principles and activation mechanisms of these multi-domain proteins implicated in the control of virulence gene expression in several pathogens.
Foussard
M
M
Groupe de Cristallographie Biologique, IPBS-CNRS, 205, route de Narbonne, 31077, Toulouse, France.
Cabantous
S
S
Pédelacq
J
J
Guillet
V
V
Tranier
S
S
Mourey
L
L
Birck
C
C
Samama
J
J
D000595:Amino Acid Sequence; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000737:chemistry / Q000378:metabolism; D000071677:Histidine Kinase; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism; D016415:Sequence Alignment; D015398:Signal Transduction / Q000502:physiology*
D001426:Bacterial Proteins; D011494:Protein Kinases; D000071677:Histidine Kinase