The genetics of signal transduction and the effect of smoking on intrauterine growth.
We have studied cytosolic low molecular weight phosphotyrosine phosphatase (cLMWPTP or ACP1) in 364 healthy puerperae from the population of Penne, in 155 diabetic puerperae from the population of Rome and in 349 consecutive normal newborn infants from the population of Rome. The data from these independent samples point to a protective role of maternal ACP1 genotypes with medium-high activity against intrauterine growth retardation caused by smoking.
Bottini
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E
Chair of Preventive and Social Pediatrics, University of Rome, Tor Vergata, School of Medicine, Rome, Italy. bottini@med.uniroma2.it
Gloria-Bottini
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F
La Torre
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M
Lucarini
N
N
D000704:Analysis of Variance; D001724:Birth Weight; D016022:Case-Control Studies; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced* / Q000453:epidemiology; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007527:Isoenzymes / Q000235:genetics*; D007558:Italy / Q000453:epidemiology; D011247:Pregnancy / Q000235:genetics*; D011254:Pregnancy in Diabetics / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D015398:Signal Transduction / Q000235:genetics*; D012907:Smoking / Q000009:adverse effects* / Q000235:genetics*
D007527:Isoenzymes; D011518:Proto-Oncogene Proteins; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases