title: Laminaria versus extra-amniotic saline solution infusion for cervical ripening in second-trimester labor inductions.
abstract: OBJECTIVE
  The aim of this study was to determine which cervical ripening method, laminaria placement or extra-amniotic saline solution infusion, was associated with the shorter interval from induction to delivery in the second trimester.
  
  
  METHODS
  Women admitted for indicated second-trimester labor induction with an unfavorable cervix were randomly assigned to receive either intracervical placement of laminaria (n = 25) or extra-amniotic saline solution infusion (n = 25) with concurrent concentrated oxytocin and vaginally administered prostaglandin E2 (10 mg every 6 hours). Treatment success was defined as an interval from induction to delivery of < or =24 hours.
  
  
  RESULTS
  Maternal age, race, parity, gestational age, and initial cervical dilatation were similar between the groups. Indications for uterine evacuation were also similar and included fetal death (n = 7), aneuploidy (n = 20), fetal structural anomaly (n = 18), and maternal indications (n = 4). There was no difference in the mean intervals from induction to delivery (laminaria, 16 +/- 8 hours, vs extra-amniotic saline solution infusion, 17 +/- 10 hours) or the number of treatment successes (laminaria, n = 23, vs extra-amniotic saline solution infusion, n = 21). Retained placenta, live birth, and hemorrhage occurred with similar frequencies in the two groups.
  
  
  CONCLUSIONS
  Relative to laminaria, extra-amniotic saline solution infusion did not shorten the induction-to-delivery interval in women undergoing indicated second-trimester labor induction with concentrated oxytocin and low-dose vaginally administered prostaglandin E2.
authors.affiliation: Department of Obstetrics and Gynecology, University of Alabama at Birmingham, 35249-7333, USA.
authors.forename: B B
authors.initials: BB
authors.lastname: Hogg
authors.forename: J
authors.initials: J
authors.lastname: Owen
mesh_terms: D000028:Abortion, Induced; D020070:Cervical Ripening; D002584:Cervix Uteri / Q000187:drug effects* / Q000502:physiology*; D036861:Delivery, Obstetric; D015232:Dinoprostone / Q000494:pharmacology; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D007795:Laminaria / Q000502:physiology*; D010121:Oxytocin / Q000494:pharmacology; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012965:Sodium Chloride / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D012965:Sodium Chloride; D010121:Oxytocin; D015232:Dinoprostone