Increased acute phase reactants are associated with levels of lipoproteins and increased carotid plaque volume.
OBJECTIVE
to test the hypotheses that increased acute phase reactants predict elevated levels of lipoproteins and increased plaque volume as well as echolucency of carotid plaques.


METHODS
the study included 258 patients with >or =50% carotid artery stenosis. Acute phase reactants (orosomucoid, C-reactive protein (CRP)) were measured in the fasting state, and ultracentrifugated lipoproteins before and after a standardised fat load test. Echogenicity of carotid plaques was detected using high-resolution B-mode ultrasound and computer-assisted image processing. A subgroup of 81 patients underwent carotid endarterectomy.


RESULTS
on linear regression analysis orosomucoid levels were positively associated with fasting and postprandial levels of all triglyceride-rich lipoproteins, and negatively associated with HDL cholesterol (p -values <0.0001); results for CRP were less pronounced. Orosomucoid and CRP both predicted the presence of an increased carotid plaque volume on univariate analysis (p =0.01 and p =0.02). Finally, orosomucoid was negatively associated with echolucency of carotid plaques ( p =0.05).


CONCLUSIONS
elevated levels of acute phase reactants are strongly associated with elevated levels of triglyceride-rich lipoproteins, increased plaque volume, and borderline significantly associated with echolucency of carotid plaques. Elevated acute phase reactants possibly predict severity of atherosclerosis, and presence of lipid-rich, rupture-prone plaques.
Grønholdt
M L
ML
Department of Vascular Surgery, RK 3112, Rigshospitalet, Blegdamsvej 9, DK-2100 Copenhagen Ø, Denmark.
Sillesen
H
H
Wiebe
B M
BM
Laursen
H
H
Nordestgaard
B G
BG
D000368:Aged; D000704:Analysis of Variance; D019540:Area Under Curve; D001161:Arteriosclerosis / Q000097:blood* / Q000000981:diagnostic imaging; D002097:C-Reactive Protein / Q000378:metabolism*; D016893:Carotid Stenosis / Q000097:blood* / Q000000981:diagnostic imaging / Q000601:surgery; D016009:Chi-Square Distribution; D016894:Endarterectomy, Carotid; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D016014:Linear Models; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism*; D011237:Predictive Value of Tests; D012307:Risk Factors; D018615:Ultrasonography, Doppler, Color
D008074:Lipoproteins; D009961:Orosomucoid; D002097:C-Reactive Protein