Evaluation of methanolic extract of Ficus platyphylla on gastrointestinal activity.
Methanolic extract of Ficus platyphylla was tested on isolated rabbit jejunum, rat duodenum and gastrointestinal motility in mice. The extract showed a biphasic effect on isolated smooth muscle. Lower concentration of extract caused contraction, while higher concentrations produced relaxation. The contractile phase was attenuated by atropine, while relaxant phase attenuated histamine induced contraction of guinea pig ileum. The extract also exhibited a dose-dependent inhibition of gastrointestinal motility. Acute toxicity test in mice established LD50 value (i.p.) of the extract to be 2000 mg/kg. Preliminary phytochemical screening of the extract gave positive test for flavonoids, tannins and saponins.
Amos
S
S
Department of Pharmacology and Toxicology, National Institute for Pharmaceutical Research and Development, P. M. B. 21, Abuja, Nigeria. samsonamos@yahoo.co.uk
Binda
L
L
Chindo
B
B
Akah
P
P
Abdurahman
M
M
Danmallam
H U
HU
Wambebe
C
C
Gamaniel
K
K
D000818:Animals; D004064:Digestive System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales / Q000737:chemistry*
D010936:Plant Extracts