title: TrkA and TrkB neurotrophin receptor immunoreactivity in the teleost (Scorpaena porcus) endocrine pancreas.
abstract: Mammalian-like and specific neurotrophins, as well as their cognate tyrosine kinase Trk-like receptors have been identified in teleosts. They are mainly distributed in neuronal tissues, but evidence suggests that some non-neuronal tissues also express Trks. In this study we used immunohistochemistry to investigate the occurrence and cell distribution of Trks in the pancreas of teleosts (Scorpaena porcus). Immunoreactivity for TrkA and TrkB, but not for TrkC receptors, was found in the scorpionfish pancreas. TrkA-like positive cells were exclusively observed within pancreatic islets, among insulin- and glucagon-containing cells, but apparently did not co-localize with these hormones. TrkB immunostaining was found in islet cells, presumably colocalized with glucagon, as well as in some cells of the exocrine portion. These data provide a morphological basis for a role of the TrkA and TrkB ligands in the endocrine pancreas of teleosts.
authors.affiliation: Dipartimento di Strutture, Funzioni e Tecnologie Biologiche, Università di Napoli Federico II, Naples, Italy. lucini@unina.it
authors.forename: C
authors.initials: C
authors.lastname: Lucini
authors.forename: L
authors.initials: L
authors.lastname: Maruccio
authors.forename: P
authors.initials: P
authors.lastname: De Girolamo
authors.forename: J A
authors.initials: JA
authors.lastname: Vega
authors.forename: L
authors.initials: L
authors.lastname: Castaldo
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D005399:Fishes; D007150:Immunohistochemistry; D007515:Islets of Langerhans / Q000737:chemistry*; D020917:Receptor, trkA / Q000032:analysis* / Q000276:immunology; D020813:Receptor, trkB / Q000032:analysis* / Q000276:immunology
chemical_list: D020917:Receptor, trkA; D020813:Receptor, trkB