title: [Expression of beta 2-adrenoceptor on peripheral lymphocyte and the level of plasma cAMP in patients with pregnancy induced hypertension].
abstract: OBJECTIVE
  To evaluate the alteration of beta 2-adrenoceptor-cAMP system in patients with pregnancy-induced hypertension (PIH).
  
  
  METHODS
  The Bmax of beta 2-adrenoceptor on the lymphocyte was examined by radioligand binding technique. The level of plasma cAMP was observed by radio competitive protein binding assay.
  
  
  RESULTS
  The Bmax of beta 2-adrenoceptor (259 fmol/10(6) cell +/- 22 fmol/10(6) cell) on the lymphocytes was significantly higher in PIH group than in control group (247 fmol/10(6) cell +/- 23 fmol/10(6) cell). There was no significant difference between the PIH group and the controls. The content of plasma cAMP (2.94 nmol/40 microliters +/- 0.91 nmol/40 microliters) was significantly higher in PIH group than in control group (0.19 nmol/40 microliters +/- 0.05 nmol/40 microliters).
  
  
  CONCLUSIONS
  The mechanism of PIH may be related with the activity of beta 2-adrenoceptor-cAMP system.
authors.affiliation: Department of Obstetrics and Gynecology, Second Teaching Hospital, Bethune University of Medical Sciences, Changchun 130041, China.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Chen
authors.forename: W
authors.initials: W
authors.lastname: Zhang
mesh_terms: D000328:Adult; D000242:Cyclic AMP / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D011869:Radioligand Assay; D011943:Receptors, Adrenergic, beta / Q000097:blood*
chemical_list: D011943:Receptors, Adrenergic, beta; D000242:Cyclic AMP