New quinolones and the impact on resistance.
The changes in quinolone research have been fast and exciting over the past 5-7 years with the discovery and development of several new 8-methoxy quinolones. An additional factor is the design of the so-called 4th-generation quinolones that lack the C-6 fluorine, which might impact the development of quinolone resistance. The science behind the quinolone susceptibility and resistance patterns is fascinating, but has not yet been clearly delineated in discussions of the advantages of quinolone usage in the clinic.
Dougherty
T J.
TJ
Department of Microbiology, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, 06492, Wallingford, CT, USA
Beaulieu
D
D
Barrett
J F.
JF