title: Gabapentin and gabapentin monohydrate.
abstract: Gabapentin [1-(aminomethyl)cyclohexaneacetic acid, C9H17NO2] is a zwitterion in the solid state. Its crystal structure involves extensive hydrogen bonding between the NH3(+) and COO(-) groups of neighboring molecules. The structure of gabapentin monohydrate [1-(aminomethyl)cyclohexaneacetic acid monohydrate, C9H17NO2-H2O] also involves such hydrogen bonding and, in addition, has a hydrogen-bonding network comprising the water molecules and both the NH3(+) and COO(-) groups.
authors.affiliation: Department of Chemistry, Northwestern University, Evanston, IL 60208-3113, USA. ibers@chem.northwestern.edu
authors.forename: J A
authors.initials: JA
authors.lastname: Ibers
mesh_terms: D000085:Acetates / Q000737:chemistry*; D000588:Amines; D000927:Anticonvulsants / Q000737:chemistry*; D018360:Crystallography, X-Ray; D003509:Cyclohexanecarboxylic Acids; D000077206:Gabapentin; D006860:Hydrogen Bonding; D015394:Molecular Structure; D014867:Water / Q000737:chemistry; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D014867:Water; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin