Host-pathogen interactions promoting inflammatory Lyme arthritis: use of mouse models for dissection of disease processes.
Recent studies have confirmed the infectious and inflammatory nature of arthritis induced by Borrelia burgdorferi, or Lyme arthritis. This arthritis is directed by the presence of the bacteria in joint tissue, and is mediated through activation of the Toll-like receptor 2 (TLR2) signaling pathways by borrelial lipoproteins. Several host genes regulate the severity of arthritis, possibly by regulating the balance of pro- and anti-inflammatory responses.
Wooten
R M
RM
Division of Cell Biology and Immunology, Department of Pathology, 50 North Medical Drive, University of Utah School of Medicine, Salt Lake City, Utah 84132, USA. mark.wooten@path.utah.edu
Weis
J J
JJ
D000818:Animals; D001170:Arthritis, Infectious / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D015748:Borrelia burgdorferi Group / Q000276:immunology; D004195:Disease Models, Animal; D008074:Lipoproteins / Q000276:immunology; D008193:Lyme Disease / Q000276:immunology / Q000503:physiopathology*; D051379:Mice
D008074:Lipoproteins