Diagnosis of oral premalignant and malignant lesions using cytomorphometry.
In this study cytomorphometry has been applied to smears collected from the buccal mucosa. Normal cells and the cells collected from lesions with no dysplasia, dysplasia and squamous. cell carcinoma were differentiated using discriminant analysis based on nuclear and cell diameter values. Cytomorphometrically the dysplastic and malignant cells were well discriminated from the normal cells. A sensitivity of 89%, specificity of 89.7%, positive predictive value of 80% and negative predictive value of 94.4% were obtained when comparing non-dysplastic lesions with dysplastic lesions.
Ramaesh
T
T
Dept of Basic Sciences, Faculty of Dental Sciences, University of Peradeniya, Peradeniya, Sri-Lanka.
Mendis
B R
BR
Ratnatunga
N
N
Thattil
R O
RO
D000328:Adult; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000473:pathology; D002467:Cell Nucleus / Q000648:ultrastructure; D048429:Cell Size; D003581:Cytodiagnosis / Q000379:methods*; D016002:Discriminant Analysis; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000175:diagnosis / Q000473:pathology; D008297:Male; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000473:pathology; D011230:Precancerous Conditions / Q000175:diagnosis* / Q000473:pathology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity; D013223:Statistics as Topic