Plasmodium falciparum homologue of the genes for Plasmodium vivax and Plasmodium yoelii adhesive proteins, which is transcribed but not translated.
The 235-kDa family of rhoptry proteins in Plasmodium yoelii and the two reticulocyte binding proteins of P. vivax comprise a family of proteins involved in host cell selection and erythrocyte invasion. Here we described a member of the gene family found in P. falciparum (PfRH3) that is transcribed in its entirety, under stage-specific control, with correct splicing of the intron, but appears not to be translated, probably due to two reading frameshifts at the 5' end of the gene.
Taylor
H M
HM
National Institute for Medical Research, Mill Hill, London NW7 1AA, United Kingdom. htaylor@nimr.mrc.ac.uk
Triglia
T
T
Thompson
J
J
Sajid
M
M
Fowler
R
R
Wickham
M E
ME
Cowman
A F
AF
Holder
A A
AA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002448:Cell Adhesion; D002875:Chromosomes; D016368:Frameshift Mutation; D017125:Genes, Protozoan / Q000235:genetics*; D008969:Molecular Sequence Data; D010963:Plasmodium falciparum / Q000235:genetics* / Q000254:growth & development; D010966:Plasmodium vivax / Q000235:genetics; D010967:Plasmodium yoelii / Q000235:genetics; D014176:Protein Biosynthesis; D015800:Protozoan Proteins / Q000235:genetics* / Q000378:metabolism*; D017422:Sequence Analysis, DNA; D017385:Sequence Homology; D014158:Transcription, Genetic
D015800:Protozoan Proteins