[Effect of Wulong Dan on treatment of acute cerebral infarction and change of hormones in hypothalamus-pituitary-thyroid axis].
OBJECTIVE
To explore the effect of Wulong Dan (WLD) on treatment of acute cerebral infarction and change of hormones in hypothalamus-pituitary-thyroid axis.


METHODS
Thirty five cases of the treated group treated with WLD by taken orally and 31 cases of the control group treated with nimoton taken orally. And dextran was given intravenously to both groups. Blood level of triiodothyronine (T3), free triiodothyronine (FT3), thyroxine (T4), free thyroxine (FT4) and thyroid stimulating hormone (TSH) of all patients were determined before and after treatment by radioimmunoassay.


RESULTS
After 4 weeks of treatment, there were significant difference between the treated group and the control group in cure rate, markedly effective rate, cure score and disappearance of clinical symptoms (P < 0.01). The levels of T3, FT3, TSH of all patients were lower than those of the normal control before treatment. After treatment with WLD and dextran, the above-mentioned indexes turned to normal.


CONCLUSIONS
WLD has a significant effect on patients with cerebral infarction on the basis of improved microcirculation induced by dextran. It also has regulatory effect on the hypothalamus-pituitary-thyroid axis disorder so as to be helpful in maintaining the homeostasis.
Peng
K
K
Department of TCM, First Military Medical University, Guangzhou(510515).
D000328:Adult; D000368:Aged; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000378:metabolism; D003911:Dextrans / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use; D008875:Middle Aged; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000378:metabolism; D013974:Thyroxine / Q000378:metabolism*; D014284:Triiodothyronine / Q000378:metabolism
D003911:Dextrans; D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine