title: Nafuredin, a novel inhibitor of NADH-fumarate reductase, produced by Aspergillus niger FT-0554.
abstract: A novel compound, nafuredin, was isolated as an inhibitor of anaerobic electron transport (NADH-fumarate reductase). It was obtained from culture broth of Aspergillus niger FT-0554 isolated from a marine sponge. The structure was elucidated as an epoxy-delta-lactone with an attached methylated olefinic side chain on the basis of spectral analysis.
authors.affiliation: Research Center for Biological Function, The Kitasato Institute, Tokyo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ui
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
authors.forename: R
authors.initials: R
authors.lastname: Masuma
authors.forename: T
authors.initials: T
authors.lastname: Nagamitsu
authors.forename: D
authors.initials: D
authors.lastname: Takano
authors.forename: T
authors.initials: T
authors.lastname: Sunazuka
authors.forename: M
authors.initials: M
authors.lastname: Namikoshi
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D001234:Aspergillus niger / Q000145:classification / Q000378:metabolism* / Q000648:ultrastructure; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008855:Microscopy, Electron, Scanning; D015394:Molecular Structure; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D044925:Oxidoreductases Acting on CH-CH Group Donors; D011753:Pyrones / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology*
chemical_list: D004791:Enzyme Inhibitors; D011753:Pyrones; C423563:nafuredin; D010088:Oxidoreductases; D044925:Oxidoreductases Acting on CH-CH Group Donors; C020155:fumarate reductase (NADH)