title: Long-term effects of pergolide in the treatment of restless legs syndrome.
abstract: An open follow-up of a controlled study in patients with restless legs syndrome (RLS) shows that the beneficial effect of pergolide on RLS symptoms persists throughout at least 1 year. Twenty-two patients of 28 (78.6%) continued to take pergolide. Polysomnographic measurements showed a persistent improvement of PLM index, PLMS arousal index, total sleep time, and sleep efficiency (p = 0.0001). Side effects, in particular nausea, were common but were well controlled by domperidone in most patients.
authors.affiliation: Department of Neurology, Center of Nervous Diseases, Philipps University of Marburg, Germany. stiasny@mailer.uni-marburg.de
authors.forename: K
authors.initials: K
authors.lastname: Stiasny
authors.forename: T C
authors.initials: TC
authors.lastname: Wetter
authors.forename: J
authors.initials: J
authors.lastname: Winkelmann
authors.forename: U
authors.initials: U
authors.lastname: Brandenburg
authors.forename: T
authors.initials: T
authors.lastname: Penzel
authors.forename: M
authors.initials: M
authors.lastname: Rubin
authors.forename: H P
authors.initials: HP
authors.lastname: Hundemer
authors.forename: W H
authors.initials: WH
authors.lastname: Oertel
authors.forename: C
authors.initials: C
authors.lastname: Trenkwalder
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D018491:Dopamine Agonists / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017060:Patient Satisfaction; D010479:Pergolide / Q000008:administration & dosage* / Q000009:adverse effects; D017286:Polysomnography / Q000187:drug effects; D012148:Restless Legs Syndrome / Q000188:drug therapy* / Q000503:physiopathology; D012890:Sleep / Q000187:drug effects / Q000502:physiology; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D018491:Dopamine Agonists; D010479:Pergolide