title: Evidence-based medicine: botulinum toxin in focal hyperhidrosis.
abstract: All studies performed so far indicate that BTX-A is a safe and effective treatment for focal hyperhidrosis of the axillae and palms, for gustatory sweating, and for some other rare conditions associated with focal hyperhidrosis. Based on two large well-designed, double-blind, placebo-controlled study there is class 1 evidence for the efficacy of BTX-A in axillary hyperhidrosis, and class 2 evidence for BTX-A in gustatory and palmar sweating (classification according to the Quality Standards Subcommittee of the American Academy of Neurology, 1994). Other indications (forehead sweating, plantar hyperhidrosis, truncal sweating) are only anecdotally reported.
authors.affiliation: Department of Neurology, University of Würzburg, Josef-Schneider-Str. 11 97080 Würzburg, Germany. naumann@mail.uni-wuerzburg.de
authors.forename: M
authors.initials: M
authors.lastname: Naumann
mesh_terms: D000818:Animals; D019274:Botulinum Toxins, Type A / Q000627:therapeutic use*; D018849:Controlled Clinical Trials as Topic / Q000379:methods / Q000706:statistics & numerical data; D019317:Evidence-Based Medicine / Q000379:methods / Q000706:statistics & numerical data*; D006801:Humans; D006945:Hyperhidrosis / Q000188:drug therapy*; D009465:Neuromuscular Agents / Q000627:therapeutic use*; D013547:Sweating, Gustatory / Q000188:drug therapy*
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A