Preliminary evaluation of endocrine cells in the rat respiratory tract after thyroid and parathyroid gland removal.
The complete thyroid and parathyroid gland removal leads to the abrupt reduction of calcitonin, which can be a factor stimulating growth and intensified activity of APUD system cells in the respiratory tract. Thus, neuroendocrine cells in the lungs and trachea in rats after thyroid and parathyroid removal were evaluated. Paraffin specimens of the examined organs were stained with H+E and impregnated with silver. Calcitonin, synaptophysin, somatostatin, and neuronal-specific enolase were detected immunohistochemically by the use of rabbit specific antibodies. Antibodies used in the study immunostained neuroendocrine cells of the examined organs. Rats with removed thyroid and parathyroid glands presented weakened reaction compared to the control group.
Sawicki
B
B
Department of Histology and Embryology, Medical Academy, Białystok, Poland.
Kasacka
I
I
Azzadin
A
A
Dadan
J
J
Malla
H
H
Nowosielski
C
C
Buczko
W
W
Niklińska
W
W
D001078:APUD Cells / Q000378:metabolism; D000818:Animals; D005260:Female; D007150:Immunohistochemistry; D008168:Lung / Q000166:cytology; D009490:Neurosecretory Systems / Q000166:cytology*; D016105:Parathyroidectomy; D051381:Rats; D017208:Rats, Wistar; D012137:Respiratory System / Q000166:cytology*; D013965:Thyroidectomy