title: [Contrast-enhanced three-dimensional MR angiography of the carotid artery at 1.0 Tesla compared to i.a. DSA: is the method suitable for the diagnosis of carotid stenosis?].
abstract: OBJECTIVE
  To evaluate the efficacy of three-dimensional, contrast-enhanced magnetic resonance angiography (CE-MRA) of the carotid artery with a 1.0 T system in comparison to intra-arterial conventional angiography (i.a.CA) for the assessment of carotid artery disease.
  
  
  METHODS
  55 patients with suspected stenosis of the carotid artery were examined with a 3 D-CE gradient-echo sequence on a 1.0 T scanner (TR/TE = 6.2/2.2 ms) and a selective DSA i.a. angiography. Image quality was evaluated by estimating the arterial contrast and venous enhancement. Morphological pathologies were registered for all arteries, stenoses of the internal carotid artery were graded by applying the NASCET criteria.
  
  
  RESULTS
  Sensitivity and specificity of MRA in detecting high-grade stenosis (> or = 70%) and occlusion of the extracranial internal carotid artery were 97.7 and 94.0%. Therapeutic relevant misinterpretations were mostly based on overestimating the stenoses.
  
  
  CONCLUSIONS
  The applied CE-MRA technique with a 1.0 T system is suitable for the assessment of carotid artery stenoses. In case of a therapeutically relevant stenosis revealed by MRA, however, verification of the diagnosis by i.a. CA is recommended.
authors.affiliation: Klinik für Radiologie, Johannes Gutenberg Universität Mainz. oberholz@radiologie.klinik.uni-mainz.de
authors.forename: K
authors.initials: K
authors.lastname: Oberholzer
authors.forename: K F
authors.initials: KF
authors.lastname: Kreitner
authors.forename: P
authors.initials: P
authors.lastname: Kalden
authors.forename: M
authors.initials: M
authors.lastname: Pitton
authors.forename: M
authors.initials: M
authors.lastname: Requardt
authors.forename: M
authors.initials: M
authors.lastname: Thelen
mesh_terms: D000368:Aged; D015901:Angiography, Digital Subtraction; D017536:Carotid Artery, Common; D002343:Carotid Artery, Internal; D016893:Carotid Stenosis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003287:Contrast Media; D003937:Diagnosis, Differential; D005260:Female; D005682:Gadolinium; D006801:Humans; D007089:Image Enhancement; D018810:Magnetic Resonance Angiography / Q000379:methods; D008297:Male; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D005682:Gadolinium