title: Specific kappa opioid receptor agonists.
abstract: The results of studies on the design of a heterocyclic scaffold for the dynorphin A pharmacophore and on structure-affinity relationships in the MPCB/CCB series are described. The representative ligands provide insights to binding modes of benzomorphan derivatives to the kappa opioid receptor.
authors.affiliation: Department of Pharmaceutical Sciences, University of Catania, Italy. ggrmedch@mbox.unict.it
authors.forename: G
authors.initials: G
authors.lastname: Ronsisvalle
authors.forename: A
authors.initials: A
authors.lastname: Marrazzo
authors.forename: L
authors.initials: L
authors.lastname: Pasquinucci
authors.forename: O
authors.initials: O
authors.lastname: Prezzavento
authors.forename: M
authors.initials: M
authors.lastname: Pappalardo
authors.forename: F
authors.initials: F
authors.lastname: Vittorio
mesh_terms: D000701:Analgesics, Opioid / Q000494:pharmacology*; D000818:Animals; D015195:Drug Design; D004399:Dynorphins / Q000494:pharmacology; D006801:Humans; D017473:Receptors, Opioid, kappa / Q000819:agonists*; D013329:Structure-Activity Relationship
chemical_list: D000701:Analgesics, Opioid; D017473:Receptors, Opioid, kappa; D004399:Dynorphins