title: Metabolic engineering as an integrating platform for strain development.
abstract: Integration of the analytical framework and experimental tools of metabolic engineering with emerging technologies such as DNA microarrays and directed evolution stands to dramatically improve the approaches by which strain improvement and biocatalyst design are pursued in the future. Progress in genomics and applied molecular biology, together with increasing emphasis on renewable resource utilization for chemical production, has advanced metabolic engineering to the forefront of biotechnological interest.
authors.affiliation: Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Stafford
authors.forename: G
authors.initials: G
authors.lastname: Stephanopoulos
mesh_terms: D007218:Industrial Microbiology; D008967:Molecular Biology