title: 5,5-Diaryl-2-amino-4-pentenoates as novel, potent, and selective glycine transporter type-2 reuptake inhibitors.
abstract: A novel series of 5,5-diaryl-2-amino-4-pentenoates was synthesized and found to be potent and selective glycine transporter type-2 reuptake inhibitors.
authors.affiliation: NPS Pharmaceuticals Inc., 6850 Goreway Drive, L4V 1V7, Mississauga, ON, Canada. misaac@npsallelix.com
authors.forename: M
authors.initials: M
authors.lastname: Isaac
authors.forename: A
authors.initials: A
authors.lastname: Slassi
authors.forename: K D
authors.initials: KD
authors.lastname: Silva
authors.forename: J
authors.initials: J
authors.lastname: Arora
authors.forename: N
authors.initials: N
authors.lastname: MacLean
authors.forename: B
authors.initials: B
authors.lastname: Hung
authors.forename: K
authors.initials: K
authors.lastname: McCallum
mesh_terms: D000475:Alkenes / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D026921:Amino Acid Transport Systems, Neutral; D000963:Antimetabolites / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002352:Carrier Proteins / Q000037:antagonists & inhibitors*; D050487:Glycine Plasma Membrane Transport Proteins; D013329:Structure-Activity Relationship
chemical_list: D000475:Alkenes; D026921:Amino Acid Transport Systems, Neutral; D000963:Antimetabolites; D002352:Carrier Proteins; D050487:Glycine Plasma Membrane Transport Proteins