Chagas disease: recombinant Trypanosoma cruzi antigens for serological diagnosis.
Diagnosis of individuals infected by Trypanosoma cruzi is performed mainly by serological tests using crude antigens, which might crossreact with other infections. In the past ten years, many recombinant T. cruzi proteins and synthetic peptides have been described, and some are already on the market. Managers of laboratories and blood banks need to make decisions on a cost-benefit basis whether to include these new-generation tests. Here, we indicate antigens that are likely to prove most useful.
da Silveira
J F
JF
Dept Micro, Imuno e Parasitologia da Escola Paulista de Medicina, UNIFESP, Rua Botucatu 862, CEP 04023-062, São Paulo, Brazil.
Umezawa
E S
ES
Luquetti
A O
AO
D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D001771:Blood Banks; D014355:Chagas Disease / Q000175:diagnosis*; D003362:Cost-Benefit Analysis; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D015337:Multicenter Studies as Topic; D011933:Reagent Kits, Diagnostic / Q000191:economics; D011994:Recombinant Proteins / Q000276:immunology; D012698:Serologic Tests / Q000379:methods; D014349:Trypanosoma cruzi / Q000276:immunology*; D014944:World Health Organization
D000953:Antigens, Protozoan; D011933:Reagent Kits, Diagnostic; D011994:Recombinant Proteins