Phenylnaphthalene compounds from the subterranean part of Vitex rotundifolia and their antibacterial activity against methicillin-resistant Staphylococcus aureus.
A careful investigation of the subterranean part of Vitex rotundifolia has shown that this plant contains five novel lignans having a 1-phenylnaphthalene-type skeleton together with four known lignans. These structures were elucidated on the basis of spectroscopic data. Furthermore, some of the isolated compounds showed antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA).
Kawazoe
K
K
Faculty of Pharmaceutical Sciences, The University of Tokushima, Tokushima, 770-8505, Japan. kawazoe@ph2.tohushima-u.ac.jp
Yutani
A
A
Tamemoto
K
K
Yuasa
S
S
Shibata
H
H
Higuti
T
T
Takaishi
Y
Y
D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001208:Asia; D013058:Mass Spectrometry; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D009281:Naphthalenes / Q000302:isolation & purification* / Q000494:pharmacology*; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013211:Staphylococcus aureus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D009281:Naphthalenes