title: Tamoxifen citrate induced sperm shape abnormalities in the in vivo mouse.
abstract: The genotoxic potential of an anticancer drug, tamoxifen citrate, was studied in the in vivo mouse system using the sperm abnormality assay. Sperms of Swiss albino mice were examined after 5 weeks of repeated administration of different doses of the drug for 10 days. The doses used were 0.1, 0.2, 0.4 and 0.8 mg/kg b.w. per day. Statistically significant sperm abnormalities revealed the genotoxic potency of this drug.
authors.affiliation: Department of Biotechnology, Kuvempu University, Jnana Sahyadri, 577451, Shimoga, India. root@shikuvem-kar.nic.in
authors.forename: S
authors.initials: S
authors.lastname: Padmalatha Rai
authors.forename: K K
authors.initials: KK
authors.lastname: Vijayalaxmi
mesh_terms: D000284:Administration, Oral; D000818:Animals; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D013076:Sperm Count; D013094:Spermatozoa / Q000187:drug effects* / Q000473:pathology; D013629:Tamoxifen / Q000008:administration & dosage / Q000633:toxicity*; D013737:Testis / Q000187:drug effects / Q000473:pathology
chemical_list: D018931:Antineoplastic Agents, Hormonal; D009153:Mutagens; D013629:Tamoxifen