title: Localization of (99m)Tc HMDP in an extraskeletal myxoid chondrosarcoma: a case report.
abstract: Extraskeletal myxoid chondrosarcoma of the lower extremity is rare, and slowly progressive. The authors of this article present the case of a man with progressive enlargement of the right thigh that underwent bone scintigraphy. The bone images showed a diffuse, moderate increase in uptake in the swollen right thigh. Despite chemotherapy, the patient died 28 mo later. At autopsy, it was confirmed that he had extraskeletal myxoid chondrosarcoma of the right thigh, which had metastasized to the upper arms, left scapula, lungs, pleurae, and right lower quadrant of the abdomen. The myxoid chondroid matrix, a major feature of the extraskeletal myxoid chondrosarcoma, is thought to account for the localization of the bone-imaging agent.
authors.affiliation: Nuclear Medicine Service and Pathology Service, Lexington VA Medical Center, Lexington, KY 40511, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Shih
authors.forename: B
authors.initials: B
authors.lastname: Mitchell
authors.forename: S
authors.initials: S
authors.lastname: Magoun
authors.forename: B
authors.initials: B
authors.lastname: Wierzbinski
mesh_terms: D000368:Aged; D002813:Chondrosarcoma / Q000000981:diagnostic imaging* / Q000556:secondary; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives; D013848:Thigh
chemical_list: D019275:Radiopharmaceuticals; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013669:Technetium Tc 99m Medronate