Use of sirolimus in kidney transplantation.
Sirolimus, which has a distinctive mechanism of action that inhibits cytokine-driven cell proliferation and maturation, provides an exciting addition to the immunosuppressive regimen for organ transplantation. A significant decrease in the number and severity of rejection episodes has been noted when sirolimus is used; it also offers the potential for patients to be withdrawn from steroids, making kidney transplantation an option for many more potential recipients. Toxic conditions such as hyperlipidemia, thrombocytopenia, and leukopenia become transient and manageable with reduction of the sirolimus dose and/or countermeasure therapy.
Podbielski
J
J
University of Texas Medical School at Houston, Houston, Tex., USA.
Schoenberg
L
L
D004334:Drug Administration Schedule; D004347:Drug Interactions; D016903:Drug Monitoring; D006084:Graft Rejection / Q000517:prevention & control*; D006801:Humans; D007166:Immunosuppressive Agents / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000009:adverse effects / Q000276:immunology*; D020123:Sirolimus / Q000276:immunology* / Q000494:pharmacology / Q000627:therapeutic use*; D014181:Transplantation Immunology; D016896:Treatment Outcome
D007166:Immunosuppressive Agents; D020123:Sirolimus