title: High-resolution three-dimensional magnetic resonance imaging of the vestibular labyrinth in patients with atypical and intractable benign positional vertigo.
abstract: Benign paroxysmal positional vertigo (BPPV) is a most common cause of dizziness and usually a self-limited disease, although a small percentage of patients suffer from a permanent form and do not respond to any treatment. This persistent form of BPPV is thought to have a different underlying pathophysiology than the generally accepted canalolithiasis theory. We investigated 5 patients who did not respond to physical treatment, presented with an atypical concomitant nystagmus or both with high-resolution three-dimensional magnetic resonance imaging of the inner ear. This method provides an excellent imaging of the inner ear fluid spaces. In all 5 patients, we found structural changes such as fractures or filling defects in the semicircular canals which we did not find in control groups. One patient clinically presented with the symptoms of a 'heavy cupula'. Whereas crosssections through the ampullary region and the adjoining utricle showed no abnormalities, there were significant structural changes in the semicircular canals, which are able to provide an explanation for the symptoms of a heavy cupula.
authors.affiliation: Department of Otolaryngology, Klinikum rechts der Isar, Technical University of Munich, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Schratzenstaller
authors.forename: C
authors.initials: C
authors.lastname: Wagner-Manslau
authors.forename: C
authors.initials: C
authors.lastname: Alexiou
authors.forename: W
authors.initials: W
authors.lastname: Arnold
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001301:Audiometry, Pure-Tone; D007758:Ear, Inner / Q000033:anatomy & histology*; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000175:diagnosis; D006801:Humans; D021621:Imaging, Three-Dimensional; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D012665:Semicircular Canals / Q000033:anatomy & histology; D012720:Severity of Illness Index; D014717:Vertigo / Q000150:complications / Q000175:diagnosis*; D014722:Vestibule, Labyrinth / Q000033:anatomy & histology*