Metabotropic glutamate receptors: structure and new subtype-selective ligands.
Metabotropic glutamate receptors (mGluRs) constitute an attractive target for the development of potential neuroprotective agents. Recent advances in the elucidation of the peculiar molecular architecture of mGluRs and in the design and synthesis of subtype selective ligands are discussed.
Pellicciari
R
R
Dipartimento di Chimica e Tecnologia del Farmaco, Perugia, Italy. rp@unipg.it
Costantino
G
G
Marinozzi
M
M
Macchiarulo
A
A
Camaioni
E
E
Natalini
B
B
D000818:Animals; D006801:Humans; D018696:Neuroprotective Agents / Q000494:pharmacology*; D018094:Receptors, Metabotropic Glutamate / Q000037:antagonists & inhibitors* / Q000737:chemistry
D018696:Neuroprotective Agents; D018094:Receptors, Metabotropic Glutamate