HGV RNA sequences in liver and PBMC.
HGV has been identified in patients with chronic hepatitis of unknown aetiology and the possibility that HGV may be the cause has been raised. We have analysed liver biopsies and PBMC (peripheral blood mononuclear cells) from 80 patients with chronic hepatitis and HGV-RNA in serum by PCR. In ten patients HGV-RNA was detected in liver, in five patients it was detected in PBMC and seven were positive in both specimens by PCR. Whether this agent resides and replicates in hepatocytes remains controversial and needs more studies.
Quiros
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E
Department of Microbiology, Faculty of Medicine, University of Granada, Spain.
Piédrola
G
G
Maroto
M C
MC
D001483:Base Sequence; D002908:Chronic Disease; D017931:DNA Primers; D018067:Flaviviridae / Q000235:genetics*; D006525:Hepatitis, Viral, Human / Q000097:blood / Q000378:metabolism*; D006801:Humans; D009000:Monocytes / Q000821:virology*; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood / Q000378:metabolism*
D017931:DNA Primers; D012367:RNA, Viral