Discovery of potent and selective phenylalanine derived CCR3 antagonists. Part 1.
The discovery of a series of phenylalanine derived CCR3 antagonists is reported. Parallel, solution-phase library synthesis has been utilized to delineate the structure-activity relationship leading to the synthesis of highly potent, CCR3-selective antagonists.
Dhanak
D
D
SmithKline Beecham Pharmaceuticals, 1250 South Collegeville Road, PO Box 5089, Collegeville, PA 19426-0989, USA. dash_dhanak-1@sbphrd.com
Christmann
L T
LT
Darcy
M G
MG
Jurewicz
A J
AJ
Keenan
R M
RM
Lee
J
J
Sarau
H M
HM
Widdowson
K L
KL
White
J R
JR
D006801:Humans; D010649:Phenylalanine / Q000737:chemistry* / Q000494:pharmacology*; D054397:Receptors, CCR3; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors* / Q000378:metabolism; D013329:Structure-Activity Relationship
C515350:CCR3 protein, human; D054397:Receptors, CCR3; D019707:Receptors, Chemokine; D010649:Phenylalanine