title: Improvement of schizophrenic patients' subjective well-being under atypical antipsychotic drugs.
abstract: Recent research indicates that subjective well-being is a major determinant of medication compliance in schizophrenia. However, it is yet unresolved whether atypical neuroleptics differ regarding subjective side-effects. A self-report instrument has been constructed to evaluate 'subjective well-being under neuroleptics' (SWN). The primary aims of the present study were to develop a short form of the SWN and to investigate the extent to which the atypical antipsychotic improves the patient's subjective well-being. The short form of the SWN was constructed following an item analysis based on data from 212 schizophrenic patients medicated with either typical or atypical antipsychotics. The short form of the SWN showed sufficient internal consistency and good construct validity. The SWN was only moderately correlated with positive and negative syndrome scale (PANSS) scores or changes in psychopathology (r=-0.20 to -0.37). SWN-ratings in patients receiving olanzapine were superior compared to those of patients medicated with either clozapine or risperidone on three of five domains of well-being. Clozapine reduced global psychiatric symptoms significantly more than risperidone. It is concluded that the assessment of subjective well-being under antipsychotic treatment provides an independent outcome measure which is relevant to compliance.
authors.affiliation: Universitäts-Krankenhaus Hamburg--Eppendorf, Clinic for Psychiatry and Psychotherapy, Martinistrasse 52, 20246 Hamburg, Germany. naber@uke.uni-hamburg.de
authors.forename: D
authors.initials: D
authors.lastname: Naber
authors.forename: S
authors.initials: S
authors.lastname: Moritz
authors.forename: M
authors.initials: M
authors.lastname: Lambert
authors.forename: F G
authors.initials: FG
authors.lastname: Pajonk
authors.forename: R
authors.initials: R
authors.lastname: Holzbach
authors.forename: R
authors.initials: R
authors.lastname: Mass
authors.forename: B
authors.initials: B
authors.lastname: Andresen
authors.forename: F
authors.initials: F
authors.lastname: Rajonk
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001294:Attitude to Health; D005260:Female; D006801:Humans; D008297:Male; D010349:Patient Compliance; D011594:Psychometrics; D012075:Remission, Spontaneous; D015203:Reproducibility of Results; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D011795:Surveys and Questionnaires; D016896:Treatment Outcome
chemical_list: D014150:Antipsychotic Agents