Reductive cleavage of heteroaryl c-halogen bonds by iodotrimethylsilane. Facile and regioselective dechlorination of antibiotic pyrrolnitrin.
Sako
M
M
Laboratory of Medicinal Chemistry, Gifu Pharmaceutical University, 5-6-1, Mitahora-higashi, Gifu 502-8585, Japan. sako@gifu-pu.ac.jp
Kihara
T
T
Okada
K
K
Ohtani
Y
Y
Kawamoto
H
H
D000935:Antifungal Agents / Q000737:chemistry*; D002713:Chlorine / Q000737:chemistry; D006219:Halogens / Q000737:chemistry; D010084:Oxidation-Reduction; D011764:Pyrrolnitrin / Q000737:chemistry*; D014297:Trimethylsilyl Compounds / Q000737:chemistry
D000935:Antifungal Agents; D006219:Halogens; D014297:Trimethylsilyl Compounds; C027752:iodotrimethylsilane; D002713:Chlorine; D011764:Pyrrolnitrin