title: Highly regioselective Friedländer reaction.
abstract: [reaction: see text]. A highly regioselective Friedländer reaction is described. By introduction of a phosphonate group at one of the alpha-carbons of a ketone, regioselectivity can be perfectly controlled.
authors.affiliation: Department of Process Research, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, USA. yi_xiao@merck.com
authors.forename: Y
authors.initials: Y
authors.lastname: Hsiao
authors.forename: N R
authors.initials: NR
authors.lastname: Rivera
authors.forename: N
authors.initials: N
authors.lastname: Yasuda
authors.forename: D L
authors.initials: DL
authors.lastname: Hughes
authors.forename: P J
authors.initials: PJ
authors.lastname: Reider
mesh_terms: D002244:Carbon / Q000737:chemistry; D007659:Ketones / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D000432:Methanol / Q000737:chemistry; D008956:Models, Chemical; D009287:Naphthyridines / Q000138:chemical synthesis*; D010710:Phosphates / Q000737:chemistry
chemical_list: D007659:Ketones; D009287:Naphthyridines; D010710:Phosphates; D002244:Carbon; D000432:Methanol