In vitro activities of DU-1102, a new trioxaquine derivative, against Plasmodium falciparum isolates.
The antimalarial trioxaquine derivative DU-1102, synthesized by covalent linkage between aminoquinoline and trioxane moieties, was highly active against Cameroonian isolates (mean 50% inhibitory concentration of 43 nmol/liter) of Plasmodium falciparum. There was no correlation between the responses to DU-1102 and chloroquine and only a low correlation between the responses to DU-1102 and pyrimethamine, suggesting an independent mode of action of the trioxaquine against the parasites.
Basco
L K
LK
Institut de Recherche pour le Développement-Laboratoire de Recherche sur le Paludisme, Organisation de Coordination pour la lutte contre les Endémies en Afrique Centrale (OCEAC), Yaoundé, Cameroon.
Dechy-Cabaret
O
O
Ndounga
M
M
Meche
F S
FS
Robert
A
A
Meunier
B
B
D000634:Aminoquinolines / Q000494:pharmacology*; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D019086:Bridged Bicyclo Compounds, Heterocyclic / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D011739:Pyrimethamine / Q000494:pharmacology; D012044:Regression Analysis
D000634:Aminoquinolines; D000962:Antimalarials; D019086:Bridged Bicyclo Compounds, Heterocyclic; C433786:DU 1102; D002738:Chloroquine; D011739:Pyrimethamine