title: Correlation between cognitive deficits and Abeta deposits in transgenic APP+PS1 mice.
abstract: Doubly transgenic mAPP+mPS1 mice (15-16 months) had impaired cognitive function in a spatial learning and memory task that combined features of a water maze and a radial arm maze. Nontransgenic mice learned a new platform location each day during 4 consecutive acquisition trials, and exhibited memory for this location in a retention trial administered 30 min later. In contrast, transgenic mice were, on average, unable to improve their performance in finding the hidden platform over trials. The cognitive performance of individual mice within the transgenic group were inversely related to the amount of Abeta deposited in the frontal cortex and hippocampus. These findings imply that mAPP+mPS1 transgenic mice develop deficits in cognitive ability as Abeta deposits increase. These data argue that radial arm water maze testing of doubly transgenic mice may be a useful behavioral endpoint in evaluating the functional consequences of potential AD therapies, especially those designed to reduce Abeta load.
authors.affiliation: Alzheimer's Research Laboratory, Department of Pharmacology, University of South Florida, 33612, Tampa, FL, USA
authors.forename: M N
authors.initials: MN
authors.lastname: Gordon
authors.forename: D L
authors.initials: DL
authors.lastname: King
authors.forename: D M
authors.initials: DM
authors.lastname: Diamond
authors.forename: P T
authors.initials: PT
authors.lastname: Jantzen
authors.forename: K V
authors.initials: KV
authors.lastname: Boyett
authors.forename: C E
authors.initials: CE
authors.lastname: Hope
authors.forename: J M
authors.initials: JM
authors.lastname: Hatcher
authors.forename: G
authors.initials: G
authors.lastname: DiCarlo
authors.forename: W P
authors.initials: WP
authors.lastname: Gottschall
authors.forename: D
authors.initials: D
authors.lastname: Morgan
authors.forename: G W
authors.initials: GW
authors.lastname: Arendash
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D019943:Amino Acid Substitution / Q000235:genetics; D016229:Amyloid beta-Peptides / Q000235:genetics / Q000378:metabolism*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology; D007150:Immunohistochemistry; D008297:Male; D018782:Maze Learning / Q000502:physiology; D008565:Membrane Proteins / Q000235:genetics*; D008568:Memory / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D009154:Mutation / Q000235:genetics; D019636:Neurodegenerative Diseases / Q000235:genetics / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology*; D010446:Peptide Fragments / Q000378:metabolism; D058225:Plaque, Amyloid / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D053764:Presenilin-1; D013028:Space Perception / Q000502:physiology
chemical_list: D016229:Amyloid beta-Peptides; D016564:Amyloid beta-Protein Precursor; D008565:Membrane Proteins; D010446:Peptide Fragments; D053764:Presenilin-1; C078592:amyloid beta-protein (1-40)