Lipase catalysed synthesis of optically enriched alpha-haloamides.
An efficient lipase catalysed synthesis of optically enriched alpha-halogenated amides with concomitant optical enrichment of the starting alpha-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.
Azim
A
A
Department of Chemistry, University of Delhi, Delhi-110 007, India.
Sharma
S K
SK
Olsen
C E
CE
Parmar
V S
VS
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D001596:Benzylamines / Q000737:chemistry / Q000378:metabolism; D002175:Candida / Q000201:enzymology*; D002384:Catalysis; D003514:Cyclohexylamines / Q000737:chemistry / Q000378:metabolism; D004987:Ethers / Q000494:pharmacology; D005656:Fungal Proteins / Q000187:drug effects / Q000378:metabolism; D008049:Lipase / Q000187:drug effects / Q000378:metabolism*; D020799:Pancrelipase / Q000378:metabolism; D012997:Solvents / Q000494:pharmacology; D013237:Stereoisomerism; D013552:Swine
D000588:Amines; D001596:Benzylamines; D003514:Cyclohexylamines; D004987:Ethers; D005656:Fungal Proteins; D012997:Solvents; D020799:Pancrelipase; C030796:benzylamine; C011779:diisopropyl ether; D008049:Lipase; C431349:lipase B, Candida antarctica