Echoviruses 1 and 8 are closely related genetically, and bind to similar determinants within the VLA-2 I domain.
Echoviruses (EV) 1 and 8 were originally considered to be distinct serotypes, but more recently have been considered strains of the same virus. In experiments with chimeric recombinant fusion proteins, both viruses bound to the I domain of the integrin VLA-2, and both required the same receptor residues for attachment. A full-length, infectious cDNA clone encoding EV1 was obtained; its nucleotide sequence was determined, as were the sequences encoding the EV8 capsid. EV1 and 8 show 94% amino acid identity within the capsid region and are more similar to each other than to any other human picornavirus.
Ohman
T
T
Division of Immunologic and Infectious Diseases, Children's Hospital of Philadelphia, 1202 Abramson, 3516 Civic Center Boulevard, 19104-4318, Philadelphia, PA, USA.
King
S L
SL
Krithivas
A
A
Cunningham
J
J
Dickeson
S K
SK
Santoro
S A
SA
Bergelson
J M
JM
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D002213:Capsid / Q000235:genetics; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D004274:DNA, Recombinant / Q000235:genetics; D029822:Enterovirus B, Human / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D006367:HeLa Cells; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010802:Phylogeny; D011485:Protein Binding; D017434:Protein Structure, Tertiary; D016029:Receptors, Very Late Antigen / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011991:Receptors, Virus / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D018076:DNA, Complementary; D004274:DNA, Recombinant; D016029:Receptors, Very Late Antigen; D011991:Receptors, Virus; D011993:Recombinant Fusion Proteins