Mechanisms of macrolide resistance in clinical group B streptococci isolated in France.
Macrolide susceptibility was investigated in clinical group B streptococci obtained from neonates or pregnant women in 2000 in France. Of 490 consecutive isolates, 18% were resistant to erythromycin. The erm(B), erm(A) subclass erm(TR), and mef(A) genes were harbored by 47, 45, and 6% of these strains, respectively. Two isolates did not harbor erm or mef genes.
Fitoussi
F
F
Service de Microbiologie, Hôpital Robert Debré, 75019 Paris, France.
Loukil
C
C
Gros
I
I
Clermont
O
O
Mariani
P
P
Bonacorsi
S
S
Le Thomas
I
I
Deforche
D
D
Bingen
E
E
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D018942:Macrolides; D008780:Methyltransferases / Q000235:genetics*; D008826:Microbial Sensitivity Tests; D011247:Pregnancy; D013292:Streptococcus agalactiae / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D018942:Macrolides; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase