title: Comparison of the response to the prone position between pulmonary and extrapulmonary acute respiratory distress syndrome.
abstract: OBJECTIVE
  To determine whether the response to the prone position differs between acute respiratory distress syndrome (ARDS) resulting from a pulmonary cause (ARDSp) and that from an extrapulmonary cause (ARD-Sexp).
  
  
  METHODS
  Prospective observational study in a medical ICU of a university-affiliated hospital.
  
  
  METHODS
  A consecutive series of 31 patients with ARDSp and 16 with ARDSexp within 3 days of onset of ARDS.
  
  
  METHODS
  Prone position for at least 2 h.
  
  
  RESULTS
  In ARDSp, compared with the supine position (121 +/- 49 mmHg), PaO2/FIO2 was not increased after 0.5 h but was increased after 2 h in the prone position (158 +/- 60 mmHg). In ARDSexp, compared with the supine position (106 +/- 53 mmHg), PaO2/FIO2 was increased after 0.5 h (155 +/- 91 mmHg), but was not further changed after 2 h. Marked oxygenation response (increase in PaO2/FIO2 > 40% from baseline) after 0.5 h was 23% in ARDSp and 63% in ARDSexp, and that after 2 h was 29% and 63%, respectively. Static respiratory compliance decreased in the prone position in ARDSexp (30 +/- 11 ml/cmH2O at baseline, 27 +/- 11 after 0.5 h and 25 +/- 9 after 2 h) but not in ARDSp. Consolidation score as determined on the first chest radiography taken in the prone position decreased to a greater degree in ARDSexp (-2.4 +/- 4.1) than in ARDSp (0.3 +/- 4.1).
  
  
  CONCLUSIONS
  Pulmonary ARDS and extrapulmonary ARDS in their early stages respond differently to the prone position with regard to the time course of oxygenation, respiratory mechanical behaviour, and radiographic change. These findings suggest that the early pathophysiology of ARDS differs according to the type of primary insult to the lung.
authors.affiliation: Division of Pulmonary and Critical Care Medicine, Asan Medical Centre, College of Medicine, University of Ulsan, Seoul 138-600, Korea. cmlim@www.amc.seoul.kr
authors.forename: C M
authors.initials: CM
authors.lastname: Lim
authors.forename: E K
authors.initials: EK
authors.lastname: Kim
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: T S
authors.initials: TS
authors.lastname: Shim
authors.forename: S D
authors.initials: SD
authors.lastname: Lee
authors.forename: Y
authors.initials: Y
authors.lastname: Koh
authors.forename: W S
authors.initials: WS
authors.lastname: Kim
authors.forename: D S
authors.initials: DS
authors.lastname: Kim
authors.forename: W D
authors.initials: WD
authors.lastname: Kim
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001784:Blood Gas Analysis; D002423:Cause of Death; D003422:Critical Care / Q000379:methods*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008170:Lung Compliance; D008171:Lung Diseases / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration / Q000379:methods; D016684:Prone Position; D011446:Prospective Studies; D011859:Radiography; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000000981:diagnostic imaging / Q000209:etiology* / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D012720:Severity of Illness Index; D016683:Supine Position; D016896:Treatment Outcome
chemical_list: D010100:Oxygen