title: Broadcast interference - functional genomics.
abstract: Four recent papers mark a major shift in functional genomic analysis for multicellular organisms. RNA-mediated interference was applied to inactivate individual genes systematically on a genomic scale. These studies subjected a third of the genes in the genome of Caenorhabditis elegans to reverse genetic analysis.
authors.affiliation: School of Biology, University of Leeds, Leeds, UK LS2 9JT. i.a.hope@leeds.ac.uk
authors.forename: I A
authors.initials: IA
authors.lastname: Hope
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D017238:Genes, Helminth; D016678:Genome; D023281:Genomics / Q000379:methods*; D010641:Phenotype; D012330:RNA, Double-Stranded / Q000235:genetics*; D018510:RNA, Helminth / Q000235:genetics
chemical_list: D012330:RNA, Double-Stranded; D018510:RNA, Helminth