title: [Fetal drug addiction as a consequence of maternal cocaine free base abuse during pregnancy].
abstract: BACKGROUND
  Fetal drug addiction is a serious public health problem. In the United States 10 to 15% of children have been exposed "in utero" to cocaine. In a Chilean public health service, more than 200 offspring of cocaine free base abuser have been detected.
  
  
  OBJECTIVE
  To analyze the clinical and social features of 100 children exposed to cocaine free base during fetal development.
  
  
  METHODS
  Clinical features of children born from cocaine free base consume mothers were described at birth. During subsequent follow up, growth and development, disease episodes, developmental alterations and social situation were recorded. Data was compared with other newborns from the same health service.
  
  
  RESULTS
  Compared to their normal counterparts, exposed children has a lower birth weight, the frequency of premature babies was thrice higher, and small-for-gestational age children were four times more common. There was also a higher prevalence of cardiac malformations, seizures and apnea. Hospital admissions were more frequent, prolonged and required more complex facilities. During follow up, undernutrition and stunting were more prevalent. Psychomotor retardation was present in 67% of children and behavioral disturbances in 93%. Most of these children are governmental protection.
  
  
  CONCLUSIONS
  Strategies to prevent drug abuse during pregnancy and its devastating medical and social consequences should be urgently developed (Rev Méd Chile 2000; 128: 1093-1100).
authors.affiliation: Servicio de Pediatría, DPG y Unidad de Informática Maternidad, Hospital Dr. Sótero del Río.
authors.forename: M
authors.initials: M
authors.lastname: Mena
authors.forename: P
authors.initials: P
authors.lastname: Navarrete
authors.forename: S
authors.initials: S
authors.lastname: Corvalán
authors.forename: P
authors.initials: P
authors.lastname: Bedregal
mesh_terms: D016022:Case-Control Studies; D019970:Cocaine-Related Disorders; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005315:Fetal Diseases / Q000209:etiology*; D005500:Follow-Up Studies; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D007752:Obstetric Labor, Premature / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects