Gastric leptin.
The recent discovery of gastric leptin has initiated several investigations on the possible role of leptin in digestive physiology. The following clues are currently suggested: leptin might control meal size in cooperation with Cholecystokinin, help cytoprotection of the gastric mucosa, play a role in gut inflammatory processes, regulate secretion of gastric hormones such as gastrin and somatostatin, and modulate intestinal transport of small peptides. The present review is a brief survey of the most significant advances in these issues.
Lewin
M J
MJ
Institut National de la Santé et de la Recherche Médicale (INSERM) Unité 410, Paris, France. mjmlewin@bichat.inserm.fr
Bado
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D000818:Animals; D001069:Appetite Regulation / Q000502:physiology*; D001692:Biological Transport; D002766:Cholecystokinin / Q000378:metabolism / Q000502:physiology; D019610:Cytoprotection; D005753:Gastric Mucosa / Q000166:cytology / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism / Q000502:physiology; D005756:Gastritis / Q000276:immunology / Q000378:metabolism; D006801:Humans; D020738:Leptin / Q000378:metabolism / Q000502:physiology*; D010455:Peptides / Q000378:metabolism; D013004:Somatostatin / Q000378:metabolism / Q000502:physiology
D005755:Gastrins; D020738:Leptin; D010455:Peptides; D013004:Somatostatin; D002766:Cholecystokinin