Regiospecific synthesis of 2,3-disubstituted-L-histidines and histamines.
Regiospecific synthesis of 2,3-disubstituted-L-histidines and 2,3-disubstituted histamines starting from L-histidine methyl ester and histamine is reported. The key step involves homolytic free radical alkylation via silver catalyzed oxidative decarboxylation of alkylcarboxylic acids with ammonium persulfate.
Narayanan
S
S
Department of Medicinal Chemistry, National Institute of Pharmaceutical Education and Research, Punjab, India.
Vangapandu
S
S
Jain
R
R
D000478:Alkylation; D000645:Ammonium Sulfate / Q000737:chemistry; D002384:Catalysis; D003653:Decarboxylation; D005609:Free Radicals / Q000737:chemistry; D006632:Histamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D006639:Histidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D012834:Silver / Q000737:chemistry
D005609:Free Radicals; C031276:ammonium peroxydisulfate; D012834:Silver; D006639:Histidine; D006632:Histamine; D000645:Ammonium Sulfate