Treatment of rhinitis medicamentosa with fluticasone propionate--an experimental study.
The efficacy of fluticasone propionate aqueous nasal spray (0.05% w/w) in the treatment of rhinitis medicamentosa has been studied in an animal model (guinea pig). Rhinitis medicamentosa was induced through the instillation of 0.05% naphthazoline nitrate (Privine) for 8 weeks. Fluticasone propionate nasal spray was then administered to the animals for 2 weeks. The spray successfully cleared the interstitial edema which is the pathologic hallmark of rhinitis medicamentosa. The study suggests that fluticasone propionate nasal spray can be beneficial in the treatment of patients with rhinitis medicamentosa.
Elwany
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Department of Otolaryngology, Alexandria Medical School, Alexandria, Egypt. elwany@emirates.net.ae
Abdel-Salaam
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D000281:Administration, Intranasal; D000730:Androstadienes / Q000008:administration & dosage* / Q000009:adverse effects; D000818:Animals; D004195:Disease Models, Animal; D004342:Drug Hypersensitivity / Q000188:drug therapy* / Q000473:pathology; D000068298:Fluticasone; D006168:Guinea Pigs; D008854:Microscopy, Electron; D009278:Naphazoline / Q000633:toxicity*; D014663:Nasal Decongestants / Q000633:toxicity*; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D012220:Rhinitis / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D016896:Treatment Outcome
D000730:Androstadienes; D014663:Nasal Decongestants; D000068298:Fluticasone; D009278:Naphazoline