title: [Studies on the mechanism of alpha-MSH in reducing IL-1 beta-induced fever].
abstract: The effect of alpha-melanocyte-stimulating hormone (alpha-MSH) on IL-1 beta-induced fever and release of hypothalamic cAMP was observed in the present work. The results showed that alpha-MSH markedly suppressed febrile response (P < 0.05) and decreased the cAMP content in hypothalamus in response to icv injection of IL-1 beta (P < 0.01). The cAMP content of the medium in which the hypothalamic was incubated for 40 min in the presence of IL-1 beta was significantly increased (P < 0.01). However, this increase action could be prevented by a pretreatment with alpha-MSH. The results indicate that the inhibitory effect of alpha-MSH on the enhanced synthesis and release of cAMP in hypothalamus exposed to IL-1 beta might be one of the mechanisms of suppressing fever induced by IL-1 beta.
authors.affiliation: Department of Pathophysiology and Institute of Fever Research, Medical College, Jinan University, Guangzhou 510632.
authors.forename: C F
authors.initials: CF
authors.lastname: Hu
authors.forename: H D
authors.initials: HD
authors.lastname: Wang
authors.forename: D A
authors.initials: DA
authors.lastname: Wang
authors.forename: Y P
authors.initials: YP
authors.lastname: Wang
authors.forename: C J
authors.initials: CJ
authors.lastname: Li
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D005260:Female; D005334:Fever / Q000139:chemically induced; D007031:Hypothalamus / Q000166:cytology / Q000502:physiology*; D007267:Injections; D007276:Injections, Intraventricular; D007375:Interleukin-1; D008297:Male; D008845:Microinjections; D011817:Rabbits; D000521:alpha-MSH / Q000494:pharmacology*
chemical_list: D018712:Analgesics, Non-Narcotic; D007375:Interleukin-1; D000521:alpha-MSH; D000242:Cyclic AMP