[Effects of a novel KATP channel opener JTV-506 on myocardial infarct size of isolated rat heart].
OBJECTIVE
To study the influence of a novel KATP channel opener JTV-506(JTV) on cardiac function and myocardial infarct size of isolated rat heart.


METHODS
The Langendorff apparatus was used to study the effect of JTV at different concentrations on the flow of coronary artery and the pressure of left ventricle. The effect of JTV on infarction size was observed on the isolated rat double coronary arteries perfusion model.


RESULTS
JTV 1 mumol.L-1 increased the flow of coronary artery obviously. When the concentration reached 10 mumol.L-1, JTV decreased the systolic pressure of the left ventricle. JTV 1 mumol.L-1 reduced the myocardial infarct size whether it was administrated during both preischemic and ischemic period or only during ischemic period. This effect was completely blocked by glibenclamide, but when glibenclamide was administrated alone, it showed no obvious effect on infarct size.


CONCLUSIONS
The KATP channel opener JTV can obviously dilate coronary artery and decrease cardiac systolic function when administrated at high doses. JTV was found to decrease the infarct size when administrated in doses that did not affect cardiac function. These effects were related to the opening of KATP channel.
Jia
D L
DL
Department of Cardiology, First Clinical College, China Medical University, Shenyang 110001, China.
Zheng
X W
XW
Qi
G X
GX
Hu
J
J
Zeng
D Y
DY
D000818:Animals; D002839:Chromans / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D005905:Glyburide / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology*; D015221:Potassium Channels / Q000819:agonists*; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology*
D002839:Chromans; C107494:JTV 506; D015221:Potassium Channels; D014665:Vasodilator Agents; D005905:Glyburide