title: Quantitative analysis of metronidazole in intravenous admixture with ciprofloxacin by first derivative spectrophotometry.
abstract: Metronidazole in parenteral admixture with ciprofloxacin was analysed by first-derivative spectrophotometry using the zero-crossing technique of measurement. The procedure did not require prior separation steps. The method was found to be linear (r(2)>0.999) in the range of 2.5-10 microg ml(-1) for metronidazole in absence or presence (at constant concentration) of ciprofloxacin. The first-derivative method was applied for the analysis of intravenous admixture of metronidazole and ciprofloxacin and proved to be rapid, accurate and reproducible.
authors.affiliation: Departamento de Farmacia, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Ciudad Universitaria-5000, Córdoba, Argentina.
authors.forename: E
authors.initials: E
authors.lastname: Vega
authors.forename: N
authors.initials: N
authors.lastname: Solá
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis*; D002939:Ciprofloxacin / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D008795:Metronidazole / Q000032:analysis*; D013053:Spectrophotometry
chemical_list: D000890:Anti-Infective Agents; D008795:Metronidazole; D002939:Ciprofloxacin