Design, synthesis, and preclinical characterization of novel, highly selective indole estrogens.
Miller
C P
CP
Wyeth-Ayerst Research, Chemical Sciences, 145 King of Prussia Road, Radnor, Pennsylvania 19087, USA. milerc1@war.wyeth.com
Collini
M D
MD
Tran
B D
BD
Harris
H A
HA
Kharode
Y P
YP
Marzolf
J T
JT
Moran
R A
RA
Henderson
R A
RA
Bender
R H
RH
Unwalla
R J
RJ
Greenberger
L M
LM
Yardley
J P
JP
Abou-Gharbia
M A
MA
Lyttle
C R
CR
Komm
B S
BS
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D002460:Cell Line; D045166:Estradiol Congeners / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D005260:Female; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D008958:Models, Molecular; D009929:Organ Size; D010052:Ovariectomy; D011869:Radioligand Assay; D051381:Rats; D013329:Structure-Activity Relationship; D014162:Transfection; D014599:Uterus / Q000187:drug effects
D045166:Estradiol Congeners; D007211:Indoles