title: Lipase catalysed synthesis of optically enriched alpha-haloamides.
abstract: An efficient lipase catalysed synthesis of optically enriched alpha-halogenated amides with concomitant optical enrichment of the starting alpha-haloesters is described. Candida antarctica lipase (CAL) was found to be a better catalyst over porcine pancreatic lipase (PPL) and Candida cylindracea lipase (CCL). The effect of different organic solvents was also studied.
authors.affiliation: Department of Chemistry, University of Delhi, Delhi-110 007, India.
authors.forename: A
authors.initials: A
authors.lastname: Azim
authors.forename: S K
authors.initials: SK
authors.lastname: Sharma
authors.forename: C E
authors.initials: CE
authors.lastname: Olsen
authors.forename: V S
authors.initials: VS
authors.lastname: Parmar
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D001596:Benzylamines / Q000737:chemistry / Q000378:metabolism; D002175:Candida / Q000201:enzymology*; D002384:Catalysis; D003514:Cyclohexylamines / Q000737:chemistry / Q000378:metabolism; D004987:Ethers / Q000494:pharmacology; D005656:Fungal Proteins / Q000187:drug effects / Q000378:metabolism; D008049:Lipase / Q000187:drug effects / Q000378:metabolism*; D020799:Pancrelipase / Q000378:metabolism; D012997:Solvents / Q000494:pharmacology; D013237:Stereoisomerism; D013552:Swine
chemical_list: D000588:Amines; D001596:Benzylamines; D003514:Cyclohexylamines; D004987:Ethers; D005656:Fungal Proteins; D012997:Solvents; D020799:Pancrelipase; C030796:benzylamine; C011779:diisopropyl ether; D008049:Lipase; C431349:lipase B, Candida antarctica