Concordance of deficit and non-deficit subtypes in siblings affected with schizophrenia.
Deficit and non-deficit subtypes were examined for their concordance in 83 sibling pairs of 109 schizophrenic patients belonging to 46 multiply affected families. Using a sib-pair method, we have found that the distribution of deficit and non-deficit syndromes in sibling pairs of schizophrenic patients differed significantly from chance expectation. This familial aggregation suggests that the syndrome may be used to define phenotypes for genetic studies.
Fouldrin
G
G
Unité INSERM EPI-9906, Université de Rouen, Service Hospitalo-Universitaire de Psychiatrie, CHRU C. Nicolle and CH du Rouvray, 1 Rue de Germont, F-76031, Rouen Cedex, France.
Jay
M
M
Bonnet-Brilhault
F
F
Ménard
J F
JF
Petit
M
M
Thibaut
F
F
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis*; D012565:Schizophrenic Psychology; D012801:Sibling Relations