title: t(2;5) associated with a histiocytic-monocytic neoplasm.
abstract: We describe a patient with a neoplasm derived from the histiocytic-monocytic lineage associated with t(2;5) detected by FISH. The patient presented with bone marrow involvement, no organomegaly and subsequently developed a leukaemic picture. The clinical course was aggressive and the patient died four months from diagnosis. Cell morphology, immunophenotype (CD30-, EMA-, Lisozyme+, cy CD68+ and CD45+) and DNA analysis showing germ-line configuration of the Ig/TCR chain genes ruled out the diagnosis of anaplastic large cell lymphoma (ALCL). This unusual case ilustrates that t(2;5) is not exclusive for ALCL but may be found in a few cases of rare neoplasms derived from the histiocytic-monocytic cells.
authors.affiliation: Department of Haematology and Histopathology, Hospital Universitario de Gran Canaria 'Doctor Negrín'. Las Palmas de Gran Canaria. alemeas@correo.hpino.rcanaria.es
authors.forename: A
authors.initials: A
authors.lastname: Lemes
authors.forename: S
authors.initials: S
authors.lastname: De La Iglesia
authors.forename: C
authors.initials: C
authors.lastname: Santana
authors.forename: J C
authors.initials: JC
authors.lastname: Cigudosa
authors.forename: E
authors.initials: E
authors.lastname: Matutes
authors.forename: T
authors.initials: T
authors.lastname: Molero
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D002889:Chromosomes, Human, Pair 2; D002895:Chromosomes, Human, Pair 5; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D015620:Histiocytic Disorders, Malignant / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016130:Immunophenotyping; D017404:In Situ Hybridization, Fluorescence; D007948:Leukemia, Monocytic, Acute / Q000175:diagnosis* / Q000235:genetics* / Q000473:pathology; D008297:Male; D014178:Translocation, Genetic
chemical_list: D015703:Antigens, CD