Decreased hippocampal BDNF expression after acute systemic injection of quinpirole.
We report that acute quinpirole injection reduces BDNF mRNA levels in the rat hippocampus both at 2 and 6 h after the administration. These results suggest that the neurotrophin expression may be inhibited by situations involving dopaminergic overactivity.
Fumagalli
F
F
Center of Neuropharmacology, Institute of Pharmacological Sciences University of Milan, Via Balzaretti 9, 20133, Milan, Italy.
Santero
R
R
Gennarelli
M
M
Giorgio Racagni
Riva
M A
MA
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000187:drug effects* / Q000378:metabolism; D018491:Dopamine Agonists / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D019257:Quinpirole / Q000494:pharmacology*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000378:metabolism
D019208:Brain-Derived Neurotrophic Factor; D018491:Dopamine Agonists; D012333:RNA, Messenger; D017448:Receptors, Dopamine D2; D019257:Quinpirole