title: Induction of alpha1-acid glycoprotein mRNA by cytokines and differentiation in human colon carcinoma cell.
abstract: The mRNA for the alpha1-acid glycoprotein (AAG) was expressed not only in hepatoma cells, but also in non-hepatic cancer cells. The expression of the AAG mRNA in HT-29 human colon carcinoma cells is induced by cytokines, IL-6, IL-1, and TNF-alpha, in a manner characteristic of the acute phase response, and the expression of AAG mRNA was up-regulated in differentiated HT-29 cells.
authors.affiliation: Department of Natural Sciences, College of Medicine, The Catholic University of Korea, Seoul. lsyng@cmc.cuk.ac.kr
authors.forename: Y
authors.initials: Y
authors.lastname: Lee
authors.forename: J W
authors.initials: JW
authors.lastname: Lim
authors.forename: Y M
authors.initials: YM
authors.lastname: Kim
authors.forename: I H
authors.initials: IH
authors.lastname: Lee
authors.forename: Y C
authors.initials: YC
authors.lastname: Choi
authors.forename: K C
authors.initials: KC
authors.lastname: Park
mesh_terms: D002454:Cell Differentiation; D003110:Colonic Neoplasms / Q000235:genetics* / Q000473:pathology; D016895:Culture Media, Serum-Free; D015972:Gene Expression Regulation, Neoplastic; D019073:HT29 Cells; D006367:HeLa Cells; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D015850:Interleukin-6 / Q000494:pharmacology; D009961:Orosomucoid / Q000096:biosynthesis / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D016895:Culture Media, Serum-Free; D007375:Interleukin-1; D015850:Interleukin-6; D009961:Orosomucoid; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha