title: Avascular necrosis of the femoral head in patients with prostate cancer treated with cyproterone acetate and radiotherapy.
abstract: We report the case histories of two patients with histologically confirmed adenocarcinoma of the prostate, both of whom had been treated with steroidal anti-androgen therapy in the form of cyproterone acetate prior to radical or palliative pelvic irradiation, and who subsequently developed femoral head avascular necrosis. This is a diagnosis that should be considered in patients with prostate cancer who present with hip pain in the absence of biochemical evidence of disease progression.
authors.affiliation: ANCHOR Unit, Aberdeen Royal Infirmary, Foresterhill, Aberdeen AB25 2ZN, UK. Graham.Macdonald@arh.grampian.scot.nhs.uk
authors.forename: A G
authors.initials: AG
authors.lastname: Macdonald
authors.forename: J D
authors.initials: JD
authors.lastname: Bissett
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000532:radiotherapy*; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects*; D017373:Cyproterone Acetate / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005271:Femur Head Necrosis / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects*
chemical_list: D000970:Antineoplastic Agents; D017373:Cyproterone Acetate