Novel cytotoxic 4-phenylfuranocoumarins from Calophyllum dispar.
Eight new 4-phenylfuranocoumarins (1-8) have been isolated from the stem bark and the fruits of Calophyllum dispar, together with three known coumarins. The structures of 1-8 were established by means of spectroscopic analysis, including extensive 2D NMR studies. Some of these furanocoumarins exhibited significant cytotoxic activity against KB cells.
Guilet
D
D
SONAS, UFR des Sciences Pharmaceutiques et Ingénierie de la Santé, 16 Bd Daviers, F-49100 Angers, France.
Hélesbeux
J J
JJ
Séraphin
D
D
Sévenet
T
T
Richomme
P
P
Bruneton
J
J
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D006801:Humans; D007624:KB Cells; D013058:Mass Spectrometry; D019441:Plant Epidermis / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet
D000972:Antineoplastic Agents, Phytogenic; D003374:Coumarins