Hypoglycemic effect of Suaeda fruticosa in streptozotocin-induced diabetic rats.
The purpose of this study was to examine the hypoglycemic activity of the aqueous extract of the aerial part of Suaeda fruticosa (SF) in normal and streptozotocin-induced diabetic rats. The aqueous extract was administered intravenously (i.v.) and the blood glucose changes were determined within 4 h after starting the treatment. Plasma insulin, cholesterol and triglycerides levels were also determined. The aqueous extract at a dose of 192 mg/kg produced a significant decrease in blood glucose levels in normal rats (P < 0.05), and even more in diabetic rats (P < 0.001). This hypoglycemic effect might be due to an extra-pancreatic action of the aqueous extract of SF, since that the levels of plasma insulin were unchanged between the values before and after treatment. In the other hand, the effect of the aqueous extract on the plasma cholesterol were also significant in both normal and diabetic rats (P < 0.05). But, there is no significant effect of SF on plasma triglycerides in both groups. In order to characterize the active principle(s), which could be responsible for the therapeutic effect, preliminary phytochemical analysis of the aqueous extract of the plant has been investigated.
Benwahhoud
M
M
UFR Physiology-Pharmacology. Laboratory of Animal Physiology. Faculty of Science Dhar-Mahraz. B.P. 1796 Atlas, Fez, Morocco.
Jouad
H
H
Eddouks
M
M
Lyoussi
B
B
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008297:Male; D009018:Morocco; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013311:Streptozocin
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D013311:Streptozocin; D002784:Cholesterol