title: Dose response effect of cyclical medroxyprogesterone on blood pressure in postmenopausal women.
abstract: OBJECTIVE
  This study was designed to compare with placebo the dose-response effect of cyclical doses of the C21 progestogen, medroxyprogesterone acetate (MPA) on blood pressure (BP) when administered to normotensive postmenopausal women receiving a fixed mid-range daily dose of conjugated equine oestrogen (CEE).
  
  
  METHODS
  Twenty normotensive postmenopausal women (median age 53 years) participated in the study which used a double-blind crossover design. There were four randomised treatment phases, each of 4 weeks duration. The four blinded treatments were MPA 2.5 mg, MPA 5 mg, MPA 10 mg and matching placebo, taken for the last 14 days of each 28 day treatment cycle. CEE 0.625 mg was also administered once daily as open labelled tablets to all subjects throughout the study. Clinic BP was measured weekly with the mean values of weeks 3 and 4 of each phase used for analysis. Ambulatory BP was performed in the final week of each phase.
  
  
  RESULTS
  Compared with the placebo phase, end of phase clinic BP was unchanged by any of the progestogen treatments. There was a dose-dependent decrease in ambulatory daytime diastolic and mean arterial BP with the progestogen treatments compared with placebo (P < 0.05).
  
  
  CONCLUSIONS
  In a regimen of postmenopausal hormone replacement therapy with a fixed mid-range daily dose of CEE combined with a cyclical regimen of a C21 progestogen spanning the current clinical dose range, the progestogen has either no effect or a small dose-dependent reduction in clinic and ambulatory BPs over one treatment cycle.
authors.affiliation: Department of Clinical Pharmacology, Flinders University of South Australia, Bedford Park, Adelaide, South Australia, Australia 5042. paula.harvey@utoronto.ca
authors.forename: P J
authors.initials: PJ
authors.lastname: Harvey
authors.forename: D
authors.initials: D
authors.lastname: Molloy
authors.forename: J
authors.initials: J
authors.lastname: Upton
authors.forename: L M
authors.initials: LM
authors.lastname: Wing
mesh_terms: D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D018660:Blood Pressure Monitoring, Ambulatory; D016009:Chi-Square Distribution; D018592:Cross-Over Studies; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008525:Medroxyprogesterone / Q000008:administration & dosage*; D008875:Middle Aged; D017698:Postmenopause; D011336:Probability; D011372:Progestins / Q000008:administration & dosage*; D012016:Reference Values
chemical_list: D011372:Progestins; D008525:Medroxyprogesterone