title: Transgenic and gene "knockout" models in alcohol research.
abstract: This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Paula L. Hoffman and Takeshi Yagi. The presentations were (1) cAMP signaling in ethanol sensitivity and tolerance, by Boris Tabakoff; (2) Synaptic signaling pathways of Fyn-tyrosine kinase, by Takeshi Yagi; (3) Ethanol drinking and sensitization in dopaminergic and serotonergic receptor knockouts, by Tamara J. Phillips; (4) ICAM-1 is involved in early alcohol-induced liver injury in the mouse given enteral alcohol, by Hiroshi Kono; and (5) Strategies for targeted and regulated knockouts, by Robert O. Messing and Doo-Sup Choi.
authors.affiliation: University of Colorado Health Sciences Center, Denver, Colorado 80262-0001, USA. paula.hoffman@uchsc.edu
authors.forename: P L
authors.initials: PL
authors.lastname: Hoffman
authors.forename: T
authors.initials: T
authors.lastname: Yagi
authors.forename: B
authors.initials: B
authors.lastname: Tabakoff
authors.forename: T J
authors.initials: TJ
authors.lastname: Phillips
authors.forename: H
authors.initials: H
authors.lastname: Kono
authors.forename: R O
authors.initials: RO
authors.lastname: Messing
authors.forename: D S
authors.initials: DS
authors.lastname: Choi
mesh_terms: D000262:Adenylyl Cyclases / Q000235:genetics / Q000378:metabolism; D000428:Alcohol Drinking / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology; D000242:Cyclic AMP / Q000235:genetics* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout / Q000235:genetics* / Q000378:metabolism; D008822:Mice, Transgenic / Q000235:genetics* / Q000378:metabolism; D023421:Models, Animal; D011518:Proto-Oncogene Proteins / Q000172:deficiency / Q000235:genetics*; D051076:Proto-Oncogene Proteins c-fyn; D011954:Receptors, Dopamine / Q000172:deficiency / Q000235:genetics; D011985:Receptors, Serotonin / Q000172:deficiency / Q000235:genetics; D015398:Signal Transduction / Q000187:drug effects / Q000235:genetics
chemical_list: D002492:Central Nervous System Depressants; D011518:Proto-Oncogene Proteins; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D018799:Intercellular Adhesion Molecule-1; D000431:Ethanol; D000242:Cyclic AMP; C494960:Fyn protein, mouse; D051076:Proto-Oncogene Proteins c-fyn; D000262:Adenylyl Cyclases