[Results and limitations of arterial infusion therapy for liver metastases from colorectal cancer].
In our institution, patients with multiple unresectable liver metastases from colorectal cancer have received 24-h continuous arterial infusion therapy of 5-fluorouracil (5-FU) 250 mg/body/day every 2 weeks for the past 11 years. Although the 5-year survival rate of those who underwent surgical resection was 35%, that of unresectable patients who received 5-FU arterial infusion was 24% at 2 years, 9% at 3 years, and 50% survived a median of 391 days. Furthermore, we were able to perform surgical resection of metastatic residual lesions in patients who responded to 5-FU arterial infusion. This therapy has proven so effective that the 3-year survival rate of these patients is now 38%, and complete cures are being achieved.
Mori
T
T
Department of Surgery, Tokyo Metropolitan Komagome Hospital, Tokyo, Japan.
Takahashi
K
K
Ohue
M
M
Yamaguchi
T
T
D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000556:secondary*; D008297:Male; D011379:Prognosis; D015996:Survival Rate
D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil