[Inadequate pharmacotherapy in patients with obsessive-compulsive disorder].
OBJECTIVE
To determine the adequacy of drug treatment for patients with obsessive compulsive disorder (OCD).


METHODS
Retrospective.


METHODS
One hundred and fifty outpatients with OCD, admitted at the University Medical Centre in Utrecht, the Netherlands, were evaluated for severity as measured with the 'Yale-Brown obsessive compulsive scale' (Y-BOCS).


RESULTS
At the intake, 35% of the patients used no medication, 58% used an antidepressant, less than 1% an antipsychotic and 6% a benzodiazepine. The average active dose was taken by 12% of the patients, 5% took the maximum dosage and 41% too low a dosage. Consequently, 6 out of the 10 patients used the correct medication (antidepressant) and less than 20% used a sufficiently high dosage. Of the patients, 38% had never previously taken antidepressants, 31% had previously used one antidepressant, 17% two different antidepressants and 12% at least three different antidepressants; 13% had taken the antidepressant at the highest dosage, 18% at the average active dosage and 31% at too low (thus ineffective) a dosage. This means that from a pharmacotherapeutic viewpoint not more than 1 in 8 patients had had an adequate treatment history.


CONCLUSIONS
The results of this study show that only 1 in 8 OCD patients were treated appropriately.
Denys
D
D
Universitair Medisch Centrum, afd. Psychiatrie, Heidelberglaan 100, 3584 CX, Utrecht. d.a.j.p.denys@azu.nl
van Megen
H J
HJ
Westenberg
H G
HG
D000328:Adult; D014151:Anti-Anxiety Agents / Q000008:administration & dosage*; D000928:Antidepressive Agents / Q000008:administration & dosage*; D001569:Benzodiazepines; D004305:Dose-Response Relationship, Drug; D011307:Drug Prescriptions / Q000706:statistics & numerical data; D004359:Drug Therapy, Combination; D004363:Drug Utilization / Q000592:standards / Q000706:statistics & numerical data*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008508:Medication Errors / Q000706:statistics & numerical data*; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy*; D010045:Outpatients / Q000706:statistics & numerical data; D012189:Retrospective Studies; D014600:Utilization Review
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D001569:Benzodiazepines