Childhood T-cell acute lymphoblastic leukemia with four distinct immunophenotypes representing different stages of T-cell development.
The authors report on a 14-year-old boy who developed T-cell acute lymphoblastic leukemia (FAB:L1) displaying 4 immunophenotypically distinct leukemic cell populations by 3-color immunofluorescence staining. Cytogenetic analysis at diagnosis showed 46,XY,add(4)(p16)[12]/46,XY[2]. A single rearrangement of the T-cell antigen receptor beta- and gamma-chain genes in these cells indicated monoclonality of the leukemic cells. These findings suggest that leukemic blast cells of monoclonal origin in this case were divided into 4 immunophenotypic populations, representing various stages of differentiation.
Miura
T
T
Department of Clinical Laboratory and Medicine, Tohoku University School of Medicine, 1-1 Seiryou-machi, Aoba-ku, Sendai, 980-8574, Japan. tm30130@mail.cc.tohoku.ac.jp
Ouhira
M
M
Koseki
N
N
Obara
Y
Y
Fujimaki
S
S
Imaizumi
M
M
Kameoka
J
J
Sasaki
T
T
Funato
T
T
Harigae
H
H
Kaku
M
M
D000293:Adolescent; D002454:Cell Differentiation; D020732:Cytogenetic Analysis; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000235:genetics / Q000276:immunology / Q000473:pathology*; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics / Q000276:immunology / Q000473:pathology*