Non-transferrin-bound iron during allogeneic stem cell transplantation.
Hydroxyl radical formation catalysed by non-transferrin-bound iron (NTBI) might contribute to transplantation-related complications. The occurrence of NTBI in 10 adult allogeneic stem cell transplantation (SCT) patients was followed for 20 d. The transferrin saturation reached 99% on d -4 and remained > 80% thereafter. NTBI, measured as bleomycin-detectable iron, was detected for 6-18 d in all patients with a peak on d -4. High transferrin saturation levels were associated with the appearance of NTBI with a threshold at 80% saturation. Prevention of the potential deleterious effects of NTBI might reduce transplantation-related morbidity.
Sahlstedt
L
L
Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland. leila.sahlstedt@hus.fi
Ebeling
F
F
von Bonsdorff
L
L
Parkkinen
J
J
Ruutu
T
T
D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007501:Iron / Q000097:blood*; D013997:Time Factors; D014168:Transferrin / Q000032:analysis; D019172:Transplantation Conditioning / Q000009:adverse effects* / Q000379:methods; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation
D007166:Immunosuppressive Agents; D014168:Transferrin; D016572:Cyclosporine; D007501:Iron