[Study of susceptibility loci located within Xp11 in attention deficit hyperactivity disorder].
OBJECTIVE
To detect the genetic relationship between monoamine oxidase(MAO) A type gene and attention deficit hyperactivity disorder(ADHD) in Chinese.


METHODS
The haplotype-based haplotype relative risk(HHRR) and the transmission disequilibrium test(TDT) methods were used to analyze the genetic association and linkage in 60 ADHD children and their parents.


RESULTS
In this sample were found significant association (chi(2)=4.90, P<0.05) and linkage (chi(2)=4.84, P<0.05) between the MAOCA 114bp allele and DSM-III-R-diagnosed ADHD in trios composed of father, mother and affected offspring.


CONCLUSIONS
The above results suggested that ADHD was associated and in linkage with MAO A gene, and the susceptibility loci might reside in chromosome Xp11 for ADHD.
Jiang
S
S
Shanghai Mental Health Center, Shanghai 200030 P. R. China.
Xin
R
R
Qian
Y
Y
Lin
S
S
Li
F
F
Wu
X
X
Wang
D
D
Tang
G
G
Jiang
K
K
D001289:Attention Deficit Disorder with Hyperactivity / Q000235:genetics*; D002648:Child; D002874:Chromosome Mapping; D005260:Female; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008995:Monoamine Oxidase / Q000235:genetics
D008995:Monoamine Oxidase