Snake toxins that bind specifically to individual subtypes of muscarinic receptors.
This paper discusses the properties of the three most specific ligands found for the extracellular faces of M1, M2 and M4 muscarinic receptors (m1-toxin1, m2-toxin and m4-toxin, respectively). The primary goal of this paper is to show the known and potential usefulness of these toxins and their biotinylated, radioactive, fluorescent and mutated derivatives.
Potter
L T
LT
Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, FL 33101, USA. lpotter@miami.edu
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004546:Elapid Venoms / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D017815:Elapidae / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D018727:Muscarinic Antagonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D009498:Neurotoxins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D043588:Receptor, Muscarinic M4; D011976:Receptors, Muscarinic / Q000378:metabolism*; D016415:Sequence Alignment
D004546:Elapid Venoms; D018727:Muscarinic Antagonists; D009498:Neurotoxins; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D043588:Receptor, Muscarinic M4; D011976:Receptors, Muscarinic; C083667:m1-toxin; C400107:m2-toxin; C098184:muscarinic toxin MT4