[Selected parameters of bone metabolism in hemodialyzed and peritoneally dialyzed patients].
Renal osteodystrophy is a metabolic bone disease occurring in patients with end-stage renal failure. The aim of the study was to compare serum concentrations of some bone markers in hemodialysed (HD) patients and in patients undergoing continuous ambulatory peritoneal dialysis (CADO). We studied two groups of patients with end-stage renal failure: 52 hemodialysed individuals aged 24-74 years and 19 peritoneally dialysed patients aged 20-70 years. Serum calcium and phosphate concentration, cholesterol, triglycerides, total protein, albumin, alkaline phosphatase, urea before and after HD, urea in CADO patients were determined by standard laboratory methods. Serum PTH, osteocalcin, 1,25(OH)2D3 and insulin-like growth factor (IGF-1) concentrations were measured by commercially available radioimmunoassay. Serum tumor necrosis factor (TNF-alpha) and interleukin-1 (IL-1) concentrations were measured by ELISA. There were no differences between serum concentrations of the studied bone markers in hemodialysed patients and CAPD patients. All dialysed patients presented high concentrations of serum PTH, osteocalcin, alkaline phosphatase activity, lower serum IGF-1 concentration and normal serum calcitriol concentration. High serum PTH and osteocalcin concentrations may indicate intensification of bone synthesis, what is typical for osteitis fibrosa.
Małyszko
J
J
Klinika Nefrologii i Chorób Wewnetrznych Akademii Medycznej w Białymstoku.
Zbroch
E
E
Wołczyński
S
S
Myśliwiec
M
M
D000328:Adult; D000368:Aged; D000418:Albumins / Q000032:analysis; D000469:Alkaline Phosphatase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002784:Cholesterol / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism* / Q000628:therapy*; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010531:Peritoneal Dialysis, Continuous Ambulatory; D010710:Phosphates / Q000097:blood; D006435:Renal Dialysis; D014280:Triglycerides / Q000097:blood
D000418:Albumins; D015415:Biomarkers; D001798:Blood Proteins; D010710:Phosphates; D014280:Triglycerides; D015675:Osteocalcin; D002784:Cholesterol; D000469:Alkaline Phosphatase; D002118:Calcium