title: High vitamin E plasma levels and low low-density lipoprotein oxidation are associated with the absence of atherosclerosis in octogenarians.
abstract: OBJECTIVE
  To identify the biological characteristics of older subjects with vascular successful aging (VASA), defined as the absence of instrumental signs and clinical symptoms of atherosclerosis in the extracoronary and coronary vessels.
  
  
  METHODS
  A cross-sectional study.
  
  
  METHODS
  A university-affiliated outpatient clinic.
  
  
  METHODS
  Sixty older subjects (30 with VASA and 30 controls with moderate carotid atherosclerosis (AG group)) from a sample of 705 subjects age 75 and older consecutively screened.
  
  
  METHODS
  Clinical examination; ultrasonographic examination of carotid, vertebral, abdominal aortic, iliac, and femoral arteries; electrocardiogram; and laboratory evaluation (lipid profile, lipophilic antioxidants, and markers of low-density lipoprotein (LDL) oxidation).
  
  
  RESULTS
  Compared with controls, there were more females in the VASA group (82% vs 50%, P <.01), and fewer previous smokers (20.5% vs 52.5%, P <.01). Vitamin E/total cholesterol levels both in plasma (4.81 vs 3.51 micromol/mmol, P <.001) and in isolated LDLs (2.71 vs 1.86 microg/mg LDL cholesterol (LDL-C), P <.01), were higher in the VASA group, as was the resistance of LDLs to in vitro oxidation (as indicated by a longer duration of the lag phase: 80.2 vs 65.6 minutes, P <.001). The level of fluorescent products of lipid peroxidation (FPLPs) in native LDLs was lower in the VASA group (13.5 vs 18.8 URF/mg LDL-C, P <.001). Multivariate logistic regression analysis showed that only plasma vitamin E level (odds ratio (OR) = 6.04, 95% confidence interval (CI) = 1.48-24.63) and FPLPs in LDLs (OR = 0.53, 95% CI = 0.31-0.91) were independently associated with VASA.
  
  
  CONCLUSIONS
  These results suggest that an appropriate level of vitamin E and a low level of LDL oxidation might be important for reaching advanced age without developing atherosclerosis.
authors.affiliation: Gerontology and Geriatrics, Department of Clinical and Experimental Medicine, University of Perugia, Perugia, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cherubini
authors.forename: G
authors.initials: G
authors.lastname: Zuliani
authors.forename: F
authors.initials: F
authors.lastname: Costantini
authors.forename: S D
authors.initials: SD
authors.lastname: Pierdomenico
authors.forename: S
authors.initials: S
authors.lastname: Volpato
authors.forename: A
authors.initials: A
authors.lastname: Mezzetti
authors.forename: P
authors.initials: P
authors.lastname: Mecocci
authors.forename: S
authors.initials: S
authors.lastname: Pezzuto
authors.forename: M
authors.initials: M
authors.lastname: Bregnocchi
authors.forename: R
authors.initials: R
authors.lastname: Fellin
authors.forename: U
authors.initials: U
authors.lastname: Senin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000097:blood*; D000975:Antioxidants / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism*; D016022:Case-Control Studies; D002784:Cholesterol / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008077:Lipoproteins, LDL / Q000378:metabolism*; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D010084:Oxidation-Reduction; D012307:Risk Factors; D017678:Sex Distribution; D012907:Smoking / Q000009:adverse effects; D014810:Vitamin E / Q000097:blood*
chemical_list: D000975:Antioxidants; D008077:Lipoproteins, LDL; D014810:Vitamin E; D002784:Cholesterol