Test-retest reliability of DSC MRI CBV mapping in healthy volunteers.
Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) can be used to generate high resolution maps of cerebral blood volume (CBV). To determine the test-retest reliability, CBV was measured in eight volunteers on two occasions, separated by 4 weeks. The mean ratio (scan 2/scan 1) for 72 cortical regions of interest (ROIs) was 1.03, with a coefficient of variation of 14%. The correlation between the first and second scans was 0.73 (p < 0.0001; 95%). In five hand-drawn ROIs, the mean ratio was 1.08, with a coefficient of variation of 12%. The correlation between scans was 0.84 (p < 0.0001). The data presented here support the hypothesis that DSC MRI CBV mapping has acceptable test-retest reliability.
Henry
M E
ME
Brain Imaging Center, McLean Hospital and The Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA.
Kaufman
M J
MJ
Lange
N
N
Schmidt
M E
ME
Purcell
S
S
Cote
J
J
Perron-Henry
D M
DM
Stoddard
E
E
Cohen
B M
BM
Renshaw
P F
PF
D000328:Adult; D001810:Blood Volume; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results