title: [Neurological manifestations in the intoxication of infants by dimethicone combined with homatropine: report of 6 cases].
abstract: OBJECTIVE
  to alert that use of dimethicone plus homatropine in infants up to two months, may cause episodes of transitory extrapyramidal disturbances.
  
  
  METHODS
  report 6 infants up to two months old, in daily use of dimethicone plus homatropine, that presented typical symptoms of the basal ganglia dysfunction, characterized by repeated crisis of short duration with tonic back shift of the head (opisthotonos), deviation of the eyes upward with looking fixed and terror expression, maintained in extending hypertonia posture of the 4 members and cry and/or guttural sounds emission.
  
  
  RESULTS
  the extrapyramidal symptoms disappeared (and did not return) after interruption of dimethicone plus homatropine. Abnormalities were not verified in neurological examination, EEG and blood tests.
  
  
  CONCLUSIONS
  the associated dimethicone/homatropine can produce in infants with less than 2 months, basal ganglia disturbances. The differentiation of these symptoms with the widespread epileptic crisis is essential, in order to avoid the erroneous use of antiepileptic drugs.
authors.affiliation: Faculdade de Medicina, Universidade de Taubaté.
authors.forename: V J
authors.initials: VJ
authors.lastname: Assencio-Ferreira
mesh_terms: D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D003085:Colic / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010276:Parasympatholytics / Q000009:adverse effects*; D012841:Simethicone / Q000009:adverse effects*; D014326:Tropanes / Q000009:adverse effects*
chemical_list: D010276:Parasympatholytics; D014326:Tropanes; D012841:Simethicone; C100236:homatropine