Levofloxacin induced polymorphic ventricular tachycardia with normal QT interval.
Polymorphic ventricular tachycardia (PVT) is a form of ventricular tachycardia characterized by QRS complexes that seem to change direction during the tachycardia. If associated with a prolonged QT interval, it is called torsades de pointes. In the absence of a congenital long QT syndrome, torsades is seen with certain drugs such as antiarrhythmic agents (Class IA, IC, III), psychotropic medications, antidepressants, antihistamines, and electrolyte disturbances. We report the first case of polymorphic ventricular tachycardia with normal QT interval associated with the oral use of levofloxacin in the absence of other etiologies known to cause these arrhythmias.
Paltoo
B
B
Section of Cardiology, Washington Hospital Center, 110 Irving St. NW, Washington, DC 20010, USA.
O'Donoghue
S
S
Mousavi
M S
MS
D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects* / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D006801:Humans; D064704:Levofloxacin; D008875:Middle Aged; D015242:Ofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D013575:Syncope / Q000139:chemically induced; D017180:Tachycardia, Ventricular / Q000139:chemically induced*; D014552:Urinary Tract Infections / Q000188:drug therapy
D000892:Anti-Infective Agents, Urinary; D064704:Levofloxacin; D015242:Ofloxacin