The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is not associated with training-induced changes in body composition: The HERITAGE Family Study.
OBJECTIVE
To investigate the association between the Trp64Arg polymorphism of the beta3-adrenergic receptor gene and changes in body composition in response to endurance training.


METHODS
Adult sedentary white and black subjects participating in the HERITAGE Family Study were measured before and after 20 weeks on endurance training for the body mass index, fat mass, percentage of body fat, fat-free mass, sum of eight skinfolds, and subcutaneous, visceral, and total abdominal fat areas. The association between the Trp64Arg polymorphism and the response phenotypes, computed as the difference between pre- and post-training values, was tested by analysis of covariance separately in men and women. The gene by race interaction term was also tested.


RESULTS
No race differences were observed for allelic and genotype frequencies. Training resulted in significant reduction of body fat in both men and women. No association of the Trp64Arg polymorphism was observed with training-induced changes for any of the body composition phenotypes in both men and women.


CONCLUSIONS
These results suggest that the Trp64Arg polymorphism of the beta3-adrenergic receptor gene is not related to changes in body composition in response to exercise training.
Garenc
C
C
Department of Preventive Medicine, Division of Kinesiology, Laval University, Ste-Foy, Québe, Canada.
Pérusse
L
L
Rankinen
T
T
Gagnon
J
J
Leon
A S
AS
Skinner
J S
JS
Wilmore
J H
JH
Rao
D C
DC
Bouchard
C
C
D000273:Adipose Tissue / Q000033:anatomy & histology; D001120:Arginine / Q000235:genetics*; D044383:Black People; D001823:Body Composition / Q000235:genetics / Q000502:physiology*; D015992:Body Mass Index; D005260:Female; D005784:Gene Amplification; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D010641:Phenotype; D010807:Physical Endurance / Q000235:genetics / Q000502:physiology*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D022702:Receptors, Adrenergic, beta-3 / Q000235:genetics*; D014364:Tryptophan / Q000235:genetics*; D044465:White People
D022702:Receptors, Adrenergic, beta-3; D014364:Tryptophan; D001120:Arginine