Sex-dependent changes in blood-brain barrier permeability in epileptic rats following acute hyperosmotic exposure.
Osmotic and ionic balance in the central nervous system is especially regulated by solutes and water transport across the blood-brain barrier. The aim of this study was to investigate the effect of systemic hyperosmolarity on the blood-brain barrier permeability in both sexes after experimentally induced seizures. Eight groups of rats were studied: Group I: female control; Group II: male control; Group III: hyperosmotic female; Group IV: hyperosmotic male; Group V: non-hyperosmotic female + seizure; Group VI: non-hyperosmotic male + seizure; Group VII: hyperosmotic female + seizure; Group VIII: hyperosmotic male + seizure. In female rats with pentylenetetrazol-induced seizures, the extravasation of Evans-blue was greater in the brains of hyperosmotic animals than that in normal rats (P < 0.02). However, in male rats, the extravasation of Evans-blue was similar in the brains of hyperosmotic male rats and normal rats after seizure. Our results concluded that hyperosmotic female rats were shown to have a large increase in blood-brain barrier permeability in comparison to hyperosmotic male rats after pentylenetetrazol-induced seizures.
Oztaş
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Department of Physiology, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Capa-34390, Turkey. bariaoztas@hotmail.com
Küçük
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Kaya
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D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D003292:Convulsants; D004827:Epilepsy / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D008297:Male; D009994:Osmolar Concentration; D010433:Pentylenetetrazole; D051381:Rats; D017208:Rats, Wistar; D012462:Saline Solution, Hypertonic / Q000633:toxicity*; D012727:Sex Characteristics
D003292:Convulsants; D012462:Saline Solution, Hypertonic; D010433:Pentylenetetrazole