title: Sildenafil (Viagra) prolongs cardiac repolarization by blocking the rapid component of the delayed rectifier potassium current.
authors.forename: G
authors.initials: G
authors.lastname: Butrous
authors.forename: R L
authors.initials: RL
authors.lastname: Siegel
mesh_terms: D015106:3',5'-Cyclic-GMP Phosphodiesterases / Q000037:antagonists & inhibitors; D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D027682:Cation Transport Proteins; D002478:Cells, Cultured; D006224:Cricetinae; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004268:DNA-Binding Proteins; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D000072237:ERG1 Potassium Channel; D004562:Electrocardiography / Q000187:drug effects; D007172:Erectile Dysfunction / Q000188:drug therapy; D004917:Erythromycin / Q000494:pharmacology; D051638:Ether-A-Go-Go Potassium Channels; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006329:Heart Conduction System / Q000187:drug effects*; D006801:Humans; D008297:Male; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism / Q000493:pharmacokinetics; D026902:Potassium Channel Blockers; D015221:Potassium Channels / Q000378:metabolism; D024642:Potassium Channels, Voltage-Gated; D011687:Purines; D000068677:Sildenafil Citrate; D013450:Sulfones; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG
chemical_list: D027682:Cation Transport Proteins; D065607:Cytochrome P-450 Enzyme Inhibitors; D004268:DNA-Binding Proteins; C072312:ERG protein, human; D000072237:ERG1 Potassium Channel; D051638:Ether-A-Go-Go Potassium Channels; C092509:KCNH6 protein, human; D010879:Piperazines; D026902:Potassium Channel Blockers; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated; D011687:Purines; D013450:Sulfones; D015534:Trans-Activators; D000071230:Transcriptional Regulator ERG; D004917:Erythromycin; D003577:Cytochrome P-450 Enzyme System; D000068677:Sildenafil Citrate; D006899:Mixed Function Oxygenases; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; D015106:3',5'-Cyclic-GMP Phosphodiesterases; D054706:Cyclic Nucleotide Phosphodiesterases, Type 5; C517381:PDE5A protein, human