Toward Understanding the Role of Methylation in Aldosterone-Sensitive Na(+) Transport.
Proper endocrine regulation of Na(+) reabsorption by renal principal cells is the primary means in mammals for maintaining blood pressure. Aldosterone increases Na(+) reabsorption by activating luminal Na(+) channels; however, the signal transduction pathway of aldosterone is not fully understood. Cellular methylation is necessary for aldosterone signaling to the luminal Na(+) channel. We describe the enzymes, regulators, and effectors of aldosterone-mediated methylation relevant to Na(+) reabsorption.
Stockand
James D.
JD
D. Stockand is in the Department of Physiology, University of Texas Health Science Center San Antonio, San Antonio, Texas 78284-7756.
Edinger
Robert S.
RS
Eaton
Douglas C.
DC
Johnson
John P.
JP