Determination of protein function, evolution and interactions by structural genomics.
The genome sequencing projects and knowledge of the entire protein repertoires of many organisms have prompted new procedures and techniques for the large-scale determination of protein structure, function and interactions. Recently, new work has been carried out on the determination of the function and evolutionary relationships of proteins by experimental structural genomics, and the discovery of protein-protein interactions by computational structural genomics.
Teichmann
S A
SA
Department of Biochemistry and Molecular Biology, University College London, Gower Street, WC1E 6BT, London, UK. sat@biochem.ucl.ac.uk
Murzin
A G
AG
Chothia
C
C
D019143:Evolution, Molecular; D023061:Gene Order; D023281:Genomics / Q000379:methods*; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry / Q000502:physiology*
D011506:Proteins