title: A comparison of the Berlin and Ghent nosologies and the influence of dural ectasia in the diagnosis of Marfan syndrome.
abstract: OBJECTIVE
  To compare the Berlin and Ghent diagnostic criteria for Marfan syndrome and evaluate the utility of screening for dural ectasia in the diagnosis of Marfan syndrome.
  
  
  METHODS
  Review of clinical and radiographic data on 73 patients evaluated for Marfan syndrome at the National Institutes of Health.
  
  
  RESULTS
  Nineteen percent of patients diagnosed under the Berlin criteria failed to meet the Ghent standard. Dural ectasia was the second most common major diagnostic manifestation, and screening for dural ectasia established the diagnosis of Marfan syndrome in 23% of patients under the Ghent criteria.
  
  
  CONCLUSIONS
  Some patients are appropriately excluded from the diagnosis of Marfan syndrome by the Ghent criteria. Determination of dural ectasia is valuable in the diagnosis of Marfan syndrome.
authors.affiliation: National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892-1852, USA. peterose@mail.mh.gov
authors.forename: P S
authors.initials: PS
authors.lastname: Rose
authors.forename: H P
authors.initials: HP
authors.lastname: Levy
authors.forename: N U
authors.initials: NU
authors.lastname: Ahn
authors.forename: P D
authors.initials: PD
authors.lastname: Sponseller
authors.forename: T
authors.initials: T
authors.lastname: Magyari
authors.forename: J
authors.initials: J
authors.lastname: Davis
authors.forename: C A
authors.initials: CA
authors.lastname: Francomano
mesh_terms: D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008382:Marfan Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging; D009316:National Institutes of Health (U.S.); D011859:Radiography; D012189:Retrospective Studies; D014481:United States