Gastroduodenal mucosal alkaline secretion and mucosal protection.
The gastroduodenal mucosa is a dynamic barrier restricting entry of gastric acid and other potentially hostile luminal contents. Mucosal HCO3(-) is a key element in preventing epithelial damage, and knowledge about HCO3(-) transport processes, including the role of the cystic fibrosis transmembrane conductance regulator channel, and their neurohumoral control are in rapid progress.
Flemström
G
G
Department of Physiology at Uppsala University, SE-751 23 Uppsala, Sweden.
Isenberg
J I
JI
D000468:Alkalies / Q000378:metabolism*; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism*; D004386:Duodenum / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*
D000468:Alkalies; D001639:Bicarbonates