Parkinsonism after glycine-derivate exposure.
This 54-year-old man accidentally sprayed himself with the chemical agent glyphosate, a herbicide derived from the amino acid glycine. He developed disseminated skin lesions 6 hours after the accident. One month later, he developed a symmetrical parkinsonian syndrome. Two years after the initial exposure to glyphosate, magnetic resonance imaging revealed hyperintense signal in the globus pallidus and substantia nigra, bilaterally, on T2-weighted images. Levodopa/benserazide 500/125 mg daily provided satisfactory clinical outcome.
Barbosa
E R
ER
Divisão de Clínica Neurológica, Hospital das Clínicas da Faculdade, Medicina da Universidade, São Paulo, São Paulo, Brazil. egbertob@8415.com.br
Leiros da Costa
M D
MD
Bacheschi
L A
LA
Scaff
M
M
Leite
C C
CC
D000978:Antiparkinson Agents / Q000627:therapeutic use; D001545:Benserazide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005917:Globus Pallidus / Q000473:pathology; D005998:Glycine / Q000031:analogs & derivatives / Q000506:poisoning*; D006540:Herbicides / Q000506:poisoning*; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology*; D013378:Substantia Nigra / Q000473:pathology; D014743:Videotape Recording; D000097797:Glyphosate
D000978:Antiparkinson Agents; D001545:Benserazide; D005998:Glycine; D006540:Herbicides; D007980:Levodopa; D000097797:Glyphosate