title: HBV-related fulminant hepatic failure: successful intensive medical therapy in a candidate for liver transplantation.
abstract: Fulminant hepatic failure (FHF) usually has a fatal prognosis without liver transplantation. We describe the case of a woman who developed FHF, and was evaluated as a candidate for liver transplantation, but who was cured without transplantation through intensive medical care that included glucagon-insulin therapy, methylprednisolone pulse therapy, interferon beta and lamivudine administration, cyclosporine administration, and high-volume hemodiafiltration and plasma exchange. In a patient with FHF who is a candidate for liver transplantation but for whom the transplantation cannot be performed for some reason, intensive medical therapy, including regeneration-promoting therapy, immunosuppressive therapy, antiviral therapy, and vigorous hepatic support, should be carried out.
authors.affiliation: First Department of Internal Medicine, Yamaguchi University, School of Medicine, Ube, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Masuhara
authors.forename: T
authors.initials: T
authors.lastname: Yagawa
authors.forename: M
authors.initials: M
authors.lastname: Aoyagi
authors.forename: C
authors.initials: C
authors.lastname: Suzuki
authors.forename: E
authors.initials: E
authors.lastname: Sakaguchi
authors.forename: M
authors.initials: M
authors.lastname: Segawa
authors.forename: K
authors.initials: K
authors.lastname: Hironaka
authors.forename: K
authors.initials: K
authors.lastname: Kayano
authors.forename: F
authors.initials: F
authors.lastname: Tamura
authors.forename: M
authors.initials: M
authors.lastname: Seguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Soejima
authors.forename: F
authors.initials: F
authors.lastname: Murakami
authors.forename: I
authors.initials: I
authors.lastname: Sakaida
authors.forename: A
authors.initials: A
authors.lastname: Tateishi
authors.forename: Y
authors.initials: Y
authors.lastname: Fukumoto
authors.forename: K
authors.initials: K
authors.lastname: Okita
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D017583:Hemodiafiltration / Q000379:methods; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D017093:Liver Failure / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D016031:Liver Transplantation; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010951:Plasma Exchange / Q000379:methods
chemical_list: D000998:Antiviral Agents; D016899:Interferon-beta; D016572:Cyclosporine; D008775:Methylprednisolone