The antiproliferative effect of coumarins on several cancer cell lines.
Twenty-one coumarins were examined for their antiproliferative activity towards several cancer cell lines, namely lung carcinoma (A549), melanin pigment producing mouse melanoma (B16 melanoma 4A5), human T-cell leukemia (CCRF-HSB-2), and human gastric cancer, lymph node metastasized (TGBC11TKB). The structure-activity relationship established from the results revealed that the 6,7-dihydroxy moiety had an important role for their antiproliferative activity. Analysis of cell cycle distribution indicated that esculetin-treated cells accumulated in the G1 (at 400 microM) or in S phase (at 100 microM).
Kawaii
S
S
Laboratory of Bio-organic Chemistry, Tokyo Denki University, Hatoyama, Saitama 350-0394, Japan.
Tomono
Y
Y
Ogawa
K
K
Sugiura
M
M
Yano
M
M
Yoshizawa
Y
Y
D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D017209:Apoptosis; D002455:Cell Division / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D053938:DNA Fragmentation; D004273:DNA, Neoplasm / Q000378:metabolism; D006131:Growth Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D003374:Coumarins; D004273:DNA, Neoplasm; D006131:Growth Inhibitors