Distribution of various calcium channel alpha(1) subunits in murine DRG neurons and antinociceptive effect of omega-conotoxin SVIB in mice.
Immunohistological study revealed the differential localization of subtypes of voltage-dependent calcium channels in the dorsal root ganglion neurons. Intrathecal injection of omega-conotoxin SVIB, an analogue of omega-conotoxin GVIA, which acts on N-type voltage-dependent calcium channels, significantly shortened the licking time in the late phase of a formalin test.
Murakami
M
M
Department of Molecular Pharmacology, Tohoku University School of Medicine, Seiryoumachi, Aoba-ku, Sendai 980-8575, Japan. mmura@mail.cc.tohoku.ac.jp
Suzuki
T
T
Nakagawasai
O
O
Murakami
H
H
Murakami
S
S
Esashi
A
A
Taniguchi
R
R
Yanagisawa
T
T
Tan-No
K
K
Miyoshi
I
I
Sasano
H
H
Tadano
T
T
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020864:Calcium Channels, N-Type / Q000032:analysis* / Q000502:physiology; D005727:Ganglia, Spinal / Q000737:chemistry* / Q000166:cytology; D007278:Injections, Spinal; D051379:Mice; D009474:Neurons / Q000737:chemistry* / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D010147:Pain Measurement / Q000187:drug effects; D020960:omega-Conotoxins / Q000494:pharmacology*
D002121:Calcium Channel Blockers; D020864:Calcium Channels, N-Type; D020960:omega-Conotoxins; C077380:omega-conotoxin SVIB