The relationship between HA-1 compatibility and the activation of helper T lymphocyte precursors.
The relationship between the compatibility in minor histocompatibility HA-1 antigen and the activation of helper (IL-2 producing) T lymphocyte precursors in vitro was studied in the group of 17 HLA-A2 positive HLA identical siblings. Although the number of pairs studied is still small, no correlation has been found between HA-1 compatibility and helper T lymphocyte precursors activation. The results presented here could suggest the possibility that the HTLp assay does not have to be a relevant parameter for the detection of HA-1 mismatches in HLA identical siblings.
Cukrová
V
V
Institute of Hematology and Blood Transfusion, Prague, Czech Republic.
Dobrovolná
M
M
Vraná
M
M
Dolezalová
L
L
Vítek
A
A
Loudová
M
M
D000208:Acute Disease; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000276:immunology; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D015789:HLA-A2 Antigen / Q000235:genetics; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D015778:Minor Histocompatibility Antigens / Q000235:genetics / Q000276:immunology*; D009679:Nuclear Family; D009842:Oligopeptides / Q000235:genetics / Q000276:immunology*; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
C110615:HA-1 antigen; D015789:HLA-A2 Antigen; D015778:Minor Histocompatibility Antigens; D009842:Oligopeptides