title: [Periurethral collagen injections: results after 2 years in 25 patients with severe urinary incontinence].
abstract: OBJECTIVE
  To study the efficacy and safety of periurethral collagen injection in the treatment of severe urinary incontinence.
  
  
  METHODS
  From 1994 to 1998, 25 periurethral collagen injections were performed in 25 women with a mean age of 65 years presenting with urinary incontinence classified as grade III in 17 cases and grade II in 9 cases, under local anaesthesia in 5 cases, spinal anaesthesia in 10 cases and general anaesthesia in 10 cases. Twenty patients were treated for recurrent incontinence. One injection was performed in 20 cases and two injections were performed in 5 cases. None of the patients presented disorders of pelvic muscles. The preoperative urodynamic assessment did not reveal any cases of detrusor instability, and showed a mean urethral closure pressure of 35 cm H2O. A skin test was performed in each case at least 30 days before the injection.
  
  
  RESULTS
  The mean hospital stay was 2.75 days. The mean quantity of collagen injected was 5.7 ml. With a mean follow-up of 24 months, 33% of patients were continent, 39% were improved and 28% were considered to be failures. No complications were observed.
  
  
  CONCLUSIONS
  Due to its safety, this method can be proposed in outpatients with good results, in patients of all ages, either as first-line treatment or for recurrent incontinence, as, in the case of failure, this technique does not comprise subsequent treatment by another operation.
authors.affiliation: Service de Chirurgie Urologique et de Transplantation Rénale, Centre Hospitalo-universitaire Rangueil, Toulouse, France.
authors.forename: X
authors.initials: X
authors.lastname: Game
authors.forename: B
authors.initials: B
authors.lastname: Malavaud
authors.forename: M
authors.initials: M
authors.lastname: Mouzin
authors.forename: P
authors.initials: P
authors.lastname: Rischmann
authors.forename: J P
authors.initials: JP
authors.lastname: Sarramon
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007267:Injections; D008875:Middle Aged; D012189:Retrospective Studies; D012720:Severity of Illness Index; D014521:Urethra; D014549:Urinary Incontinence / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; C048470:glutaraldehyde-cross-linked collagen; D003094:Collagen