Functional study of antibodies against a fibrogenin-binding protein in Staphylococcus epidermidis adherence to polyethylene catheters.
Staphylococcus epidermidis is an important pathogen in foreign body-associated infections. In a previous study, we showed that a surface-located fibrinogen-binding protein, termed Fbe, from S. epidermidis mediated the bacterial adherence to fibrinogen-coated surfaces in vitro. In the present study, we demonstrate that antibodies against Fbe can block adherence of S. epidermidis to fibrinogen-coated catheters, subcutaneously implanted catheters from rats, and peripheral venous catheters from human patients.
Pei
L
L
Division of Clinical Bacteriology, Department of Immunology, Pathology, and Microbiology, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden. lei.pei@impi.ki.se
Flock
J I
JI
D000818:Animals; D000906:Antibodies / Q000502:physiology*; D001422:Bacterial Adhesion / Q000276:immunology*; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000276:immunology* / Q000378:metabolism; D002404:Catheterization; D005340:Fibrinogen / Q000378:metabolism; D005353:Fibronectins / Q000378:metabolism; D011095:Polyethylenes; D011487:Protein Conformation; D051381:Rats; D011993:Recombinant Fusion Proteins / Q000276:immunology; D013212:Staphylococcus epidermidis / Q000276:immunology*
D000906:Antibodies; D001426:Bacterial Proteins; D002352:Carrier Proteins; C112556:Fbe protein, bacteria; D005353:Fibronectins; D011095:Polyethylenes; D011993:Recombinant Fusion Proteins; D005340:Fibrinogen