title: [Stereotaxic neurosurgery for treatment of Parkinson disease].
abstract: Three target structures are available in stereotactic surgery for Parkinson's disease: the thalamus, the globus pallidus and the subthalamic nucleus. The subthalamic nucleus appears to be the most promising structure. However, the thalamus can be considered in the case of an incapacitating tremor presenting as a primary symptom. Surgery in the globus pallidus may be as effective as in the subthalamic nucleus, but in the latter it is often accompanied by a reduction in dopaminergic medication. The surgical technique of electrical stimulation causes fewer adverse effects than that of coagulation and can therefore be applied bilaterally, but does require more intense postoperative care. In the selection of patients for surgery, levodopa responsiveness plays an important role in predicting effectiveness, except in the case of tremor.
authors.affiliation: Academisch Medisch Centrum, afd. Neurologie, Meibergdreef 9, 1105 AZ Amsterdam. j.d.speelman@amc.uva.nl
authors.forename: J D
authors.initials: JD
authors.lastname: Speelman
authors.forename: R A
authors.initials: RA
authors.lastname: Esselink
authors.forename: P R
authors.initials: PR
authors.lastname: Schuurman
authors.forename: R M
authors.initials: RM
authors.lastname: de Bie
authors.forename: D A
authors.initials: DA
authors.lastname: Bosch
mesh_terms: D004599:Electric Stimulation Therapy / Q000379:methods; D004564:Electrocoagulation / Q000379:methods; D005917:Globus Pallidus / Q000601:surgery*; D006801:Humans; D010300:Parkinson Disease / Q000601:surgery* / Q000628:therapy; D016032:Randomized Controlled Trials as Topic; D013238:Stereotaxic Techniques; D020531:Subthalamic Nucleus / Q000601:surgery*; D013788:Thalamus / Q000601:surgery*; D016896:Treatment Outcome