Preventing gastrointestinal complications of NSAIDs. Risk factors, recent advances, and latest strategies.
In the United States, gastrointestinal complications induced by nonsteroidal anti-inflammatory drugs (NSAIDs) cause more than 100,000 hospitalizations and an estimated 16,500 deaths annually. Because serious gastrointestinal events can occur without warning, prevention measures must not rely on warning signs alone. This article discusses the epidemiology of NSAID-induced toxic episodes, reviews the risk factors for these occurrences, and offers strategies for minimizing the risk among long-term NSAID users.
Graumlich
J F
JF
Department of Biomedical and Therapeutic Sciences, University of Illinois College of Medicine, PO Box 1649, Peoria, IL 61656-1649, USA. jfg@uic.edu
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000191:economics; D000068579:Celecoxib; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use; D003657:Decision Making; D016527:Drug Costs; D005767:Gastrointestinal Diseases / Q000139:chemically induced* / Q000517:prevention & control*; D006801:Humans; D011720:Pyrazoles; D012307:Risk Factors; D013449:Sulfonamides / Q000627:therapeutic use
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D011720:Pyrazoles; D013449:Sulfonamides; D000068579:Celecoxib