A simple preparation of ketones. N-protected alpha-amino ketones from alpha-amino acids.
[reaction: see text] Carboxylic acids and amino acids are readily converted, under mild conditions, into the corresponding activated esters, which are reacted with Grignard/CuI reagent to give the corresponding ketones in nearly quantitative yields. The compounds were recovered substantially pure from the reaction mixtures.
De Luca
L
L
Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy.
Giacomelli
G
G
Porcheddu
A
A