[Persistence of bilateral pigmentary deposits in stromal cornea in a woman after a brief treatment with antidepressants].
BACKGROUND
Neuropsychiatric agents may affect the eye in various ways. Phenothiazine commonly used in the treatment of depressive psychosis and schizophrenia may induce pigmentary deposits in the eyelids, conjunctiva, cornea, lens and retina.


METHODS
We report on a case of a 60-year-old female patient who presented with pigmentary changes in the cornea of unknown origin. We found bilateral, axial brown dustlike deposits in the posterior stroma of the cornea. Further ophthalmic investigation revealed no other abnormalities. Seven years ago the patient underwent therapy with fluphenazine, a phenothiazine derivative. The corneal changes were similar to those described for chlorpromazine, which is also a phenothiazine derivative.


CONCLUSIONS
Phenothiazine may induce pigmentary changes of the eye. Ophthalmic followup in patients with phenothiazine therapy seems to be necessary.
Panzitt
M
M
Universitäts-Augenklinik Graz, Auenbruggerplatz 4, 8036 Graz, Osterreich. manuela.panzitt@kfunigraz.ac.at
Simon
M
M
Weger
M
M
D014150:Antipsychotic Agents / Q000009:adverse effects*; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology; D003319:Corneal Stroma / Q000473:pathology*; D005260:Female; D005476:Fluphenazine / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology
D014150:Antipsychotic Agents; D005476:Fluphenazine