title: Efficient asymmetric synthesis of alpha-trifluoromethyl-substituted primary amines via nucleophilic 1,2-addition to trifluoroacetaldehyde SAMP- or RAMP-hydrazone.
abstract: [reaction: see text] An efficient asymmetric synthesis of alpha-trifluoromethyl-substituted primary amines via nucleophilic 1,2-addition of alkyllithium reagents to trifluoroacetaldehyde SAMP- or RAMP-hydrazone followed by benzoylation and SmI(2)-promoted nitrogen-nitrogen single bond cleavage is described.
authors.affiliation: Institut für Organische Chemie, Rheinisch-Westfälische Technische Hochschule, Professor-Pirlet-Strasse 1, 52074 Aachen, Germany. enders@rwth-aachen.de
authors.forename: D
authors.initials: D
authors.lastname: Enders
authors.forename: K
authors.initials: K
authors.lastname: Funabiki