[Acute isoniazid poisoning presenting convulsion and liver dysfunction].
A-19-year-old girl ingested 7.4 g of Isoniazid (INH) and 14.5 g of Ethambutol (EB) intentionally. She presented repetitive generalized convulsions with metabolic acidosis, treated with diazepam and 7.5 g of Pyridoxine (Vitamin B6). During day 4 and 5, liver dysfunction worsened and prothrombin time declined below 5%. She was treated with infusion of fresh frozen plasma and fully recovered on day 13. Serum concentration of INH and EB at 5 hours after ingestion was 7.6, 0.94 micrograms/ml respectively.
Kiyota
K
K
Tertiary Emergency Medical Center, Tokyo Metropolitan Bokutoh Hospital.
Hamabe
Y
Y
D000208:Acute Disease; D000328:Adult; D000995:Antitubercular Agents / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury; D004977:Ethambutol / Q000506:poisoning; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000506:poisoning*; D011041:Poisoning / Q000628:therapy; D012640:Seizures / Q000139:chemically induced*; D013406:Suicide, Attempted
D000995:Antitubercular Agents; D004977:Ethambutol; D007538:Isoniazid