X-ray hypersensitivity in the LEA rat: genetic linkage analysis of responsible loci.
The LEA rat was established from a Long-Evans rat closed colony as the control strain of the LEC rat, which is reported to exhibit several mutant phenotypes such as hepatic disorder (hts), blockage of the T cell differentiation (thid) and X-ray hypersensitivity (xhs1 and xhs2). Here we report that the LEA rat is hypersensitive to X-rays to a similar degree as the LEC rat, although it is normal with respect to the hts and thid phenotypes. We further performed genetic linkage analysis of X-ray hypersensitivity in the LEA rat. The quantitative trait loci (QTL) linkage analysis revealed that xhs1 but not xhs2 is the locus responsible for X-ray hypersensitivity in the LEA rat.
Agui
T
T
Center for Experimental Animal Science, Nagoya City University Medical School, Nagoya, Aichi 467-8601, Japan.
Miyamoto
T
T
Tsumagari
T
T
D000818:Animals; D002874:Chromosome Mapping; D004249:DNA Damage / Q000528:radiation effects*; D008040:Genetic Linkage; D018895:Microsatellite Repeats; D010641:Phenotype; D016133:Polymerase Chain Reaction; D019655:Quantitative Trait, Heritable; D011836:Radiation Tolerance / Q000235:genetics*; D051381:Rats; D020318:Rats, Long-Evans; D011922:Rats, Mutant Strains; D014965:X-Rays