title: Hepatic hemangioendothelioma associated with production of humoral thyrotropin-like factor.
abstract: We report on 7 patients referred for treatment of hepatic hemangioendothelioma with increased thyrotropin levels. The serum thyroxine level was decreased in 4 and increased in 2. Immunohistochemistry showed positive staining of tumor, but not of normal liver tissue, for thyrotropin. We propose secretion by the tumor of a thyrotropin-like factor.
authors.affiliation: Department of Clinical Biochemistry, King's College Hospital, Denmark Hill, London SE5 9RS, United Kingdom.
authors.forename: R M
authors.initials: RM
authors.lastname: Ayling
authors.forename: M
authors.initials: M
authors.lastname: Davenport
authors.forename: N
authors.initials: N
authors.lastname: Hadzic
authors.forename: R
authors.initials: R
authors.lastname: Metcalfe
authors.forename: C R
authors.initials: CR
authors.lastname: Buchanan
authors.forename: E R
authors.initials: ER
authors.lastname: Howard
authors.forename: G
authors.initials: G
authors.lastname: Mieli-Vergani
mesh_terms: D005260:Female; D006390:Hemangioendothelioma / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D013972:Thyrotropin / Q000096:biosynthesis*; D013974:Thyroxine / Q000032:analysis
chemical_list: D013972:Thyrotropin; D013974:Thyroxine