Natural and synthetic benzophenones: interaction with the cytosolic binding domain of P-glycoprotein.
A benzophenone glycoside has been isolated from Davallia solida. Its structure was elucidated by chemical and spectral means as 4-O-beta-D-glucopyranosyl-2,6,4'-trihydroxybenzophenone. It bound with moderate affinity to the purified C-terminal cytosolic domain of P-glycoprotein, but the binding affinity was 6- to 10-fold increased for its aglycone derivative and other related benzophenones.
Rancon
S
S
Laboratory of Pharmacognosy, Faculty of Pharmacy, Lyon, France.
Chaboud
A
A
Darbour
N
N
Comte
G
G
Bayet
C
C
Simon
P N
PN
Raynaud
J
J
Di Pietro
A
A
Cabalion
P
P
Barron
D
D
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D001577:Benzophenones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism*; D001665:Binding Sites / Q000502:physiology; D001685:Biological Factors / Q000302:isolation & purification / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D010936:Plant Extracts; D017434:Protein Structure, Tertiary / Q000502:physiology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001577:Benzophenones; D001685:Biological Factors; D010936:Plant Extracts