title: Carprofen inhibition of flare in the dog measured by laser flare photometry.
abstract: The purpose of this study was to determine whether oral carprofen (Rimadyl(R)) treatment in dogs could prevent or decrease the breakdown of the blood-aqueous barrier. The topical pilocarpine irritative model was used to induce breakdown and cause flare. Pilocarpine was instilled in both eyes of seven dogs at time zero and again 5 h later. At 7 h, laser flare photometry was used to measure the flare concentration in each eye using the Kowa FC-1000 laser flare cell meter. All treatments were then discontinued. Two days later, carprofen was administered to the same dogs for a total of three doses. After the last dose of carprofen, pilocarpine treatments and flare measurements were repeated. Carprofen pretreatment resulted in a 68% inhibition of flare, which was highly significant (P < 0.01). The pilocarpine group had a mean of 16.1 photon counts per millisecond (PC ms-1) +/- 2.2 SE, and the carprofen group had a mean of 7.0 PC/ms +/- 1.2 SE. These results compare favorably with previous studies measuring increased protein or fluorescein concentrations in the aqueous humor after blood-aqueous barrier breakdown in the dog. These results suggest that carprofen may be effectively used as a systemically administered ocular anti-inflammatory drug. Carprofen has the added benefit of fewer reported side effects.
authors.affiliation: Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA; Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA; Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA; Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907, USA.
authors.forename: S.G.
authors.initials: SG
authors.lastname: Krohne
authors.forename: M.J.
authors.initials: MJ
authors.lastname: Blair
authors.forename: D.
authors.initials: D
authors.lastname: Bingaman
authors.forename: J.R.
authors.initials: JR
authors.lastname: Gionfriddo