Biomarker studies on gold-lined sea bream (Rhabdosargus sarba) exposed to benzo[a]pyrene.
Gold-lined sea bream (Rhabdosargus sarba) were intraperitoneally injected with 35 mg/kg benzo[a]pyrene (in DMSO), with fish administered DMSO as the solvent control. Fish were sacrificed 3 days post injection and their livers dissected for the analysis of adenosine triphosphates (ATPase), glutathione-S-transferase (GST), DNA adducts and ethyoxyresorufin-O-deethylase (EROD). Exposure to B[a]P resulted in reduced ATPase activity, elevated GST activity and DNA adduct level, but no apparent change in EROD activity.
Xu
L
L
Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, China.
Chen
J
J
Zhang
Y
Y
Cheung
C C
CC
Lam
P K
PK
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001564:Benzo(a)pyrene / Q000009:adverse effects*; D015415:Biomarkers / Q000032:analysis; D002273:Carcinogens / Q000009:adverse effects*; D019363:Cytochrome P-450 CYP1A1 / Q000378:metabolism; D018736:DNA Adducts; D005399:Fishes / Q000502:physiology*; D005982:Glutathione Transferase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology
D015415:Biomarkers; D002273:Carcinogens; D018736:DNA Adducts; D001564:Benzo(a)pyrene; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase; D000251:Adenosine Triphosphatases