HBV-related fulminant hepatic failure: successful intensive medical therapy in a candidate for liver transplantation.
Fulminant hepatic failure (FHF) usually has a fatal prognosis without liver transplantation. We describe the case of a woman who developed FHF, and was evaluated as a candidate for liver transplantation, but who was cured without transplantation through intensive medical care that included glucagon-insulin therapy, methylprednisolone pulse therapy, interferon beta and lamivudine administration, cyclosporine administration, and high-volume hemodiafiltration and plasma exchange. In a patient with FHF who is a candidate for liver transplantation but for whom the transplantation cannot be performed for some reason, intensive medical therapy, including regeneration-promoting therapy, immunosuppressive therapy, antiviral therapy, and vigorous hepatic support, should be carried out.
Masuhara
M
M
First Department of Internal Medicine, Yamaguchi University, School of Medicine, Ube, Japan.
Yagawa
T
T
Aoyagi
M
M
Suzuki
C
C
Sakaguchi
E
E
Segawa
M
M
Hironaka
K
K
Kayano
K
K
Tamura
F
F
Seguchi
M
M
Soejima
Y
Y
Murakami
F
F
Sakaida
I
I
Tateishi
A
A
Fukumoto
Y
Y
Okita
K
K
D000998:Antiviral Agents / Q000627:therapeutic use*; D016572:Cyclosporine / Q000627:therapeutic use; D005260:Female; D017583:Hemodiafiltration / Q000379:methods; D006509:Hepatitis B / Q000150:complications*; D006801:Humans; D016899:Interferon-beta / Q000627:therapeutic use; D017093:Liver Failure / Q000175:diagnosis / Q000628:therapy* / Q000821:virology; D016031:Liver Transplantation; D008775:Methylprednisolone / Q000627:therapeutic use; D008875:Middle Aged; D010951:Plasma Exchange / Q000379:methods
D000998:Antiviral Agents; D016899:Interferon-beta; D016572:Cyclosporine; D008775:Methylprednisolone