Proteolysis-inducing factor is expressed in tumours of patients with gastrointestinal cancers and correlates with weight loss.
Proteolysis-inducing factor (PIF), a novel cachectic factor, is detectable in the urine of cancer patients experiencing weight loss. We report the expression of PIF in gastrointestinal cancers, and a correlation between PIF expression in tumours, its detection in urine and weight-loss. These data provide the first direct evidence that tumours are the source of PIF in humans.
Cabal-Manzano
R
R
Lombardi Cancer Center, Georgetown University Medical Center, 3800 Reservoir Road NW, Washington DC 20007, USA.
Bhargava
P
P
Torres-Duarte
A
A
Marshall
J
J
Bhargava
P
P
Wainer
I W
IW
D000818:Animals; D001066:Appetite; D001798:Blood Proteins / Q000096:biosynthesis* / Q000652:urine; D002100:Cachexia / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D005770:Gastrointestinal Neoplasms / Q000150:complications* / Q000503:physiopathology; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D011509:Proteoglycans; D015431:Weight Loss
D001798:Blood Proteins; D011509:Proteoglycans; C042057:proteolysis-inducing peptide