title: Intraocular lens designed for the newborn infant eye.
abstract: OBJECTIVE
  To evaluate the effects of an intraocular lens (IOL) designed for small eyes after clear lens extraction in an animal model.
  
  
  METHODS
  St. Erik's Eye Hospital, Karolinska Institute, Stockholm, Sweden.
  
  
  METHODS
  Clear lens extraction was performed in both eyes in 19 3-week-old rabbits. In 1 randomly selected eye of each rabbit, a small IOL with long haptics was implanted. Axial length, corneal thickness, corneal diameter, and intraocular pressure were measured preoperatively and every month for 6 months postoperatively. Six months after surgery, the wet mass of the after-cataract was determined.
  
  
  RESULTS
  The IOL remained well centered in all eyes. Four animals developed severe glaucoma in 5 eyes (3 aphakic and 2 pseudophakic) soon after surgery and were excluded. In the 15 animals completing the study, signs of glaucoma evolved in 7 animals (5 aphakic and 4 pseudophakic eyes). In aphakic eyes, significant amounts of after-cataract (median 250 mg) developed in all 15 surviving animals. In pseudophakic eyes, small amounts of after-cataract (median 30 mg) were present. During the first 2 months after surgery, ocular growth was less in pseudophakic eyes than in aphakic eyes.
  
  
  CONCLUSIONS
  Results indicate that implantation of a down-sized IOL with long haptics in small eyes is safe. Considerable less after-cataract was found in eyes with the IOL than in aphakic control eyes.
authors.affiliation: St Erik's Eye Hospital/Karolinska Institute, Stockholm, Sweden. anna.lundvall@sankterik.se
authors.forename: A
authors.initials: A
authors.lastname: Lundvall
authors.forename: U
authors.initials: U
authors.lastname: Kugelberg
authors.forename: B
authors.initials: B
authors.lastname: Lundgren
authors.forename: M
authors.initials: M
authors.lastname: vd Mooren
authors.forename: C
authors.initials: C
authors.lastname: Zetterström
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001036:Aphakia, Postcataract / Q000150:complications; D002386:Cataract / Q000209:etiology / Q000517:prevention & control; D005901:Glaucoma / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007231:Infant, Newborn; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000601:surgery; D007910:Lenses, Intraocular; D011183:Postoperative Complications; D011474:Prosthesis Design; D019591:Pseudophakia / Q000150:complications; D011817:Rabbits