Mechanisms of alcoholic liver disease: cytokines.
This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chair was Manuela G. Neuman. The presentations were (1) New aspects of hepatic fibrosis, by D. A. Brenner; (2) Cellular immune response in hepatitis C models, by B. Rehermann; (3) The role of interleukin-10 in acute alcoholic hepatitis, by J. Taieb, S. Chollet-Martin, M. Cohard, J. J. Garaud, and T. Poynard; (4) Cytokine-mediated apoptosis in vitro, by M. G. Neuman; (5) Signaling for apoptosis and repair in vitro, by G. G. Katz, R. G. Cameron, N. H. Shear, and M. G. Neuman; (6) Interferons activate the P42/44 mitogen-activated protein kinase and Janus Kinase signal transducers and activation of transcription (JAK-STAT) signaling pathways in hepatocytes: Differential regulation by acute ethanol via a protein kinase C-dependent mechanism, by B. Gao; (7) Genetic polymorphisms of interleukin-1 in association with the development of Japanese alcoholic liver disease, by M. Takamatsu, M. Yamauchi, M. Ohata, S. Saito, S. Maeyama, T. Uchikoshi, and G. Toda; and (8) Increased levels of macrophage migration inhibitory factor in sera from patients with alcoholic liver diseases, by T. Kumagi, S. M. F. Akbar, M. Abe, K. Michitaka, N. Horiike, and M. Onji.
Neuman
M G
MG
Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario, Canada. manuela@sten.sunnybrook.utoronto.ca
Brenner
D A
DA
Rehermann
B
B
Taieb
J
J
Chollet-Martin
S
S
Cohard
M
M
Garaud
J J
JJ
Poynard
T
T
Katz
G G
GG
Cameron
R G
RG
Shear
N H
NH
Gao
B
B
Takamatsu
M
M
Yamauchi
M
M
Ohata
M
M
Saito
S
S
Maeyama
S
S
Uchikoshi
T
T
Toda
G
G
Kumagi
T
T
Akbar
S M
SM
Abe
M
M
Michitaka
K
K
Horiike
N
N
Onji
M
M
D000428:Alcohol Drinking / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D016174:Hepacivirus / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood / Q000276:immunology; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics; D011493:Protein Kinase C / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D016207:Cytokines; D007378:Interleukins; D008263:Macrophage Migration-Inhibitory Factors; D010713:Phosphatidylcholines; D014409:Tumor Necrosis Factor-alpha; C005152:lipostabil; D007371:Interferon-gamma; D011493:Protein Kinase C; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases