title: Epileptic manifestations induced by midazolam in the neonatal period.
abstract: Antiepileptic drugs may cause worsening of epilepsy by aggravating pre-existing seizures or by triggering new seizure types. There are several reports of adverse effects related to midazolam, but only a few authors reported epileptic manifestations. We report four newborns seen at the Neonatal Intensive Care Unit of our University Hospital, who developed seizures a few seconds after the administration of midazolam. It is difficult to identify the patients at risk, but it is important to be aware and recognize this situation.
authors.affiliation: Department of Neurology, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Montenegro
authors.forename: M M
authors.initials: MM
authors.lastname: Guerreiro
authors.forename: J P
authors.initials: JP
authors.lastname: Caldas
authors.forename: M V
authors.initials: MV
authors.lastname: Moura-Ribeiro
authors.forename: C A
authors.initials: CA
authors.lastname: Guerreiro
mesh_terms: D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008874:Midazolam / Q000009:adverse effects*
chemical_list: D006993:Hypnotics and Sedatives; D008874:Midazolam