Treatment of acute myeloblastic leukaemia in a patient with Bombay blood type: a case report.
A 62-year-old female was admitted to our hospital with suspected acute leukaemia and after investigation we diagnosed acute myeloblastic leukaemia (AML-M1). The patient's blood type was found to be the very rare Bombay type and surveillance of her relatives showed the same blood type in her male cousin on her mother's side. Alongside chemotherapy the patient received 4000 ml of frozen Bombay-type red cells, 1400 ml of concentrated red cells in manitol adenine phosphate solutions and 360 units of type O concentrated platelets without marked effects. The anti-H antibody was initially at 128 dilution but for unknown reasons increased to 2048 dilution after remission of AML-M1. About 3 months after hospitalization the patient died of Cryptococcus neoformans pneumonia despite strict precautions against infection. Although AML-M1 is a common adult leukaemia and is chemosensitive to anti-leukaemic drugs, neither AML-M1 in a patient with Bombay-type red cells nor its treatment with chemotherapy and transfusion with type Oh frozen red cells have previously been reported.
Okamoto
Y
Y
Department of Blood Transfusion Medicine and Clinical Haematology, Wakayama Medical College, Wakayama City, Japan. yokamoto@wakayama-med.ac.jp
Tsuda
T
T
Matsunami
M
M
Hirose
T
T
Sakaguchi
R
R
Katayama
N
N
Ota
K
K
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001789:Blood Group Antigens; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype
D000970:Antineoplastic Agents; D001789:Blood Group Antigens