Dithiane- and trithiane-based photolabile scaffolds for molecular recognition.
[see structure]. A modular synthetic approach to novel dithiane- and trithiane-based photolabile molecular hosts equipped with elements of molecular recognition is developed. The approach provides ready access to a family of amino-derivatized photocleavable molecular systems capable of hydrogen-bonding-based recognition of biologically relevant molecules, e.g., ureas, barbiturates etc. These systems undergo efficient photofragmentation in the presence of external (e.g., benzophenone) or internal (e.g., nitropyridine) electron-transfer sensitizers.
Mitkin
O D
OD
Department of Chemistry and Biochemistry, University of Denver, Denver, Colorado 80208-2436, USA.
Kurchan
A N
AN
Wan
Y
Y
Schiwal
B F
BF
Kutateladze
A G
AG
D006571:Heterocyclic Compounds / Q000737:chemistry*; D010777:Photochemistry
D006571:Heterocyclic Compounds