title: Fatigue and health profile in sicca syndrome of Sjögren's and non-Sjögren's syndrome origin.
abstract: OBJECTIVE
  To assess the health status and fatigue in sicca patients with or without Sjögren's syndrome (SS) and to test whether the immune-inflammatory activity or the extent of the disease predict fatigue in SS.
  
  
  METHODS
  The Medical Outcomes Study Short-Form General Health Survey (MOS SF-36) was used in 1 degree SS (n = 90), 2 degrees SS (n = 24), non-SS patients with sicca symptoms (n = 15) and healthy population controls (n = 126). Laboratory values and clinical findings were used to predict fatigue in SS.
  
  
  RESULTS
  74% of the SS and 80% of the non-SS sicca patients felt themselves tired. Vitality score values were 40.2 +/- 20.3 in 1 degree SS, 42.1 +/- 20.6 in 2 degrees SS and 29.0 +/- 15.8 in non-SS. The health profiles were similar in 1 degree and 2 degrees SS, worse (p < 0.001) than in normal controls, but in most aspects better than in non-SS sicca patients. In SS neither hemoglobin, ESR nor CRP predicted fatigue. Surprisingly, high serum IgG (p < 0.05), antinuclear antibodies (ANA) (p < 0.01) and SS-A antibodies (p < 0.05) values correlated positively with vitality. The number of disease manifestations correlated negatively with vitality (p < 0.004). The total number of disease manifestations, and ANA and/or SS-A autoantibodies were the best predictors of fatigue, but explained it only to 17-57%.
  
  
  CONCLUSIONS
  Patients with fatigue and perceived ill health but without fibromyalgia had sicca symptoms and low basal tear and salivary secretion rates, indicating that cortical events can lead to a SS-like sicca syndrome. Even in SS fatigue is only in part explained by clinical disease manifestations and laboratory tests assessing inflammation and autoimmunity. Fatigue in both SS and non-SS sicca syndrome more likely correlates to other features, such as neuroendocrine aspects of the disease.
authors.affiliation: Biomedicum Helsinki, Institute of Biomedicine/Anatomy, University of Helsinki, Finland.
authors.forename: E K
authors.initials: EK
authors.lastname: Tensing
authors.forename: S A
authors.initials: SA
authors.lastname: Solovieva
authors.forename: T
authors.initials: T
authors.lastname: Tervahartiala
authors.forename: D C
authors.initials: DC
authors.lastname: Nordström
authors.forename: M
authors.initials: M
authors.lastname: Laine
authors.forename: S
authors.initials: S
authors.lastname: Niissalo
authors.forename: Y T
authors.initials: YT
authors.lastname: Konttinen
mesh_terms: D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000097:blood; D015352:Dry Eye Syndromes / Q000175:diagnosis / Q000276:immunology; D005221:Fatigue / Q000175:diagnosis* / Q000276:immunology*; D005260:Female; D006304:Health Status; D006306:Health Surveys; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012859:Sjogren's Syndrome / Q000175:diagnosis* / Q000276:immunology*
chemical_list: D000974:Antibodies, Antinuclear; D007074:Immunoglobulin G; C035356:SS-A antibodies