[Agranulocytosis in a child with schizophrenia treated with clozapine--clinical findings and therapy, a case report].
OBJECTIVE
The indication of clozapine therapy is governed by special guidelines due to a 1%-3% risk of clozapine-induced agranulocytosis. Up to now there has never been a report of such a case in a child with schizophrenia. The case report presented here is concerned with the clinical features and the treatment of clozapine-induced agranulocytosis in childhood schizophrenia.


METHODS
It deals with the treatment of a 12-yearold boy with a schizophrenic psychosis. The psychotic symptoms before treatment and during inpatient treatment are described. The procedures for the diagnosis and treatment of the clozapine-induced agranulocytosis are presented.


RESULTS
Clozapine medication may induce agranulocytosis in the treatment of a child with a schizophrenic psychosis. The highly specific guidelines governing its use must be followed as well in the treatment of very early onset schizophrenia. An agranulocytosis may result following 15 weeks of clozapine medication. The treatment with granulocyte colony-stimulating factor seems to support normalization of the blood picture.
Reitzle
K
K
Klinik für Kinder- und Jugendpsychiatrie und Psychotherapie der Julius-Maximilians-Universität Würzburg.
Warnke
A
A
Wewetzer
C
C
Müller
H
H
D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy; D002648:Child; D003024:Clozapine / Q000009:adverse effects* / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012561:Schizophrenia, Childhood / Q000175:diagnosis / Q000188:drug therapy*
D016179:Granulocyte Colony-Stimulating Factor; D003024:Clozapine