Cholesterol efflux capacity in vitro predicts the severity and extent of coronary artery disease in patients with and without type 2 diabetes.
OBJECTIVE
To investigate the relation between severity and extent of coronary artery disease (CAD) and in vitro cholesterol efflux capacity.


METHODS
This study consisted of 46 type 2 diabetic, and 42 nondiabetic men undergoing coronary angiography. Quantitative coronary angiography was used to estimate the severity, extent, and overall "atheroma burden" of CAD. The capacity of patient plasma to induce cholesterol efflux from cultured Fu5AH rat hepatoma cells was measured in vitro.


RESULTS
In the combined study population (n = 88), there was a significant inverse correlation between efflux and global atheroma burden (r = -0.23, p < 0.05). In the diabetic group, the global atheroma burden index was independently associated both with cholesterol efflux and with LpA-I levels. However, in the nondiabetic CAD group this association was lost when efflux and LpA-I levels were included in the same model.


CONCLUSIONS
The present study demonstrated that efflux capacity was inversely associated with the severity and extent of CAD. In the diabetic group this association was independent of LpA-I levels, suggesting impaired antiatherogenic potential of these particles in type 2 diabetic patients.
Pajunen
P
P
Department of Medicine, Helsinki University Central Hospital, Finland.
Syvänne
M
M
Castro
G
G
Nieminen
M S
MS
Taskinen
M R
MR
D000368:Aged; D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis* / Q000209:etiology / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000150:complications* / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D066298:In Vitro Techniques; D008297:Male; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D051381:Rats; D012307:Risk Factors; D012720:Severity of Illness Index
D002784:Cholesterol