Liver cell specific targeting of peptide nucleic acid oligomers.
Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.
Zhang
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Department of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75390-9041, USA.
Simmons
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Corey
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D000970:Antineoplastic Agents / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007785:Lactose / Q000737:chemistry; D008099:Liver / Q000166:cytology* / Q000378:metabolism; D008856:Microscopy, Fluorescence; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000494:pharmacology; D009928:Organ Specificity; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D012235:Rhodamines; D013329:Structure-Activity Relationship; D019098:Telomerase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D012235:Rhodamines; D019098:Telomerase; D007785:Lactose