Spontaneous neoplastic lesions in aged Sprague-Dawley rats.
Neoplastic lesions were observed in untreated aged Sprague Dawley (SD) rats throughout their lifespan starting at 5 weeks. Their mean survival times were 89 to 105 weeks of age. The total tumor incidences were 70 to 76.7% and 87 to 95.8% in males and females, respectively. The common neoplasmas were pituitary adenoma and adrenal pheochromocytoma in both sexes, testicular Leydig cell tumor in males and mammary gland tumors, thyroidal C-cell adenoma and uterine stromal polyp in females.
Nakazawa
M
M
Research Laboratories, Nippon Shinyaku Co., Ltd., 14 Nishinosho-Monguchicho Kisshoin, Minami-ku, Kyoto 601-8550, Japan.
Tawaratani
T
T
Uchimoto
H
H
Kawaminami
A
A
Ueda
M
M
Ueda
A
A
Shinoda
Y
Y
Iwakura
K
K
Kura
K
K
Sumi
N
N
D000236:Adenoma / Q000453:epidemiology / Q000662:veterinary; D000310:Adrenal Gland Neoplasms / Q000453:epidemiology / Q000662:veterinary; D000375:Aging; D000818:Animals; D005260:Female; D007984:Leydig Cell Tumor / Q000453:epidemiology / Q000662:veterinary; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000453:epidemiology; D009369:Neoplasms / Q000453:epidemiology / Q000662:veterinary*; D010673:Pheochromocytoma / Q000453:epidemiology / Q000662:veterinary; D010911:Pituitary Neoplasms / Q000453:epidemiology / Q000662:veterinary; D011127:Polyps / Q000453:epidemiology / Q000662:veterinary; D051381:Rats; D017207:Rats, Sprague-Dawley; D012376:Rodent Diseases / Q000453:epidemiology*; D013736:Testicular Neoplasms / Q000453:epidemiology / Q000662:veterinary; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000662:veterinary; D014594:Uterine Neoplasms / Q000453:epidemiology / Q000662:veterinary