Consistent DNA losses on the short arm of chromosome 1 in a series of malignant gastrointestinal stromal tumors.
Fourteen malignant gastrointestinal stromal tumors (GISTs), characterized by immunohistochemistry, were analyzed by comparative genomic hybridization (CGH). The most striking feature was the detection of consistent DNA losses on the short arm of chromosome 1 in these 14 malignant tumors. Additional recurrent imbalances were also found: significant gains, which could be indicative of tumor progression, were frequent on the long arm of chromosome 1, as were losses of DNA copy number detected in chromosomes 13, 14, 15 and 22.
Derré
J
J
Laboratoire de Pathologie Moléculaire des Cancers, INSERM U509 Institut Curie, Section de Recherche, 26 rue d'Ulm, 75248 Paris cedex 05, France.
Lagacé
R
R
Terrier
P
P
Sastre
X
X
Aurias
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002877:Chromosomes, Human; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics*; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D005784:Gene Amplification; D006801:Humans; D007124:Immunoenzyme Techniques; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D017384:Sequence Deletion; D017154:Stromal Cells / Q000473:pathology*
D004273:DNA, Neoplasm