title: [Re-irradiation of cerebral arteriovenous malformations. Experience of the Sainte-Anne-Tenon Group].
abstract: OBJECTIVE
  Between 20 to 50% of cerebral arteriovenous malformations treated with radiosurgery (RS) fail to obliterate 2 to 5 years after irradiation. Patients are not protected against the risks leading to treatment. Two therapeutic options can be used to eradicate the persisting nidus: micro-surgery and a second irradiation. Our group has reirradiated 39 such patients.
  
  
  METHODS
  From 1989 to 2000, 39 patients have been reirradiated (14 females and 25 males; median age 31 years). There were more left lesions: 59% than right (35%) and 5% on midline. The most frequent locations were: temporal 12 cases; parietal 8 cases; frontal 7 cases; thalamus 7 cases. The predominant first symptoms were hemorrhage (68.5%) and seizure (15.8%). Prior RS, 21/39 patients had embolization (53.8%) and 3 surgery. Method. Treatment has been performed with the same system for the first and the second radiosurgery for 37 patients. Planification and dosimetry improved during that period. The level of dose was similar for the 2 RS. MRI has been used as a non invasive follow-up tool.
  
  
  RESULTS
  Only 28 patients were evaluable because 7/39 patients had the second radiosurgery in 1999 or in 2000 and data were lacking at the time of writing for 4 patients. Obliteration rate was 17/28 (60.7%). Nine patients bled between the two radiosurgery procedures.
  
  
  RESULTS
  4 new regressive deficits occurred after the second radiosurgery. The rate of parenchymal changes were higher, after the second radiosurgery. Except one patient who died of a non-related affection 2 years after obliteration of his cerebral arteriovenous malformation, thus 38/39 patients were alive.
  
  
  CONCLUSIONS
  This series was small compared to the potential number of candidates suffering from failure of the first radiosurgery, but the results are promising.
authors.affiliation: Service d'Oncologie-Radiothérapie, Hôpital Tenon, 4, rue de la Chine, 75020 Paris.
authors.forename: M
authors.initials: M
authors.lastname: Schlienger
authors.forename: L
authors.initials: L
authors.lastname: Mérienne
authors.forename: D
authors.initials: D
authors.lastname: Lefkopoulos
authors.forename: F
authors.initials: F
authors.lastname: Nataf
authors.forename: H
authors.initials: H
authors.lastname: Mammar
authors.forename: E
authors.initials: E
authors.lastname: Deniaud-Alexandre
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000453:epidemiology / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010297:Paris / Q000453:epidemiology; D010348:Patient Care Team; D016634:Radiosurgery; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D017211:Treatment Failure; D016896:Treatment Outcome