title: Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials.
abstract: This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Jobst August-Ludwig Boening and Otto Michel Lesch. The presentations were (1) Pharmacological validation of a new animal model of alcoholism, by Rainer Spanagel; (2) Persisting loss of control as main criterion for alcohol addiction in rats and mice, by Jochen Wolffgramm; (3) Role of NMDA receptor subunits associated with protein kinase C in the prevention of alcohol dependence, by Minoru Narita; (4) Long-term follow up of continued naltrexone treatment, by David Sinclair; (5) Pharmacological treatment trials with dopaminergic and serotonergic substances: Myths or facts? by Gerhard A. Wiesbeck; and (6) Methodology and behavioral therapy of the U.S. acamprosate study, by Barbara J. Mason.
authors.affiliation: Department of Psychiatry, Addiction Medicine, University of Wuerzburg, Germany.
authors.forename: J A
authors.initials: JA
authors.lastname: Boening
authors.forename: O M
authors.initials: OM
authors.lastname: Lesch
authors.forename: R
authors.initials: R
authors.lastname: Spanagel
authors.forename: J
authors.initials: J
authors.lastname: Wolffgramm
authors.forename: M
authors.initials: M
authors.lastname: Narita
authors.forename: D
authors.initials: D
authors.lastname: Sinclair
authors.forename: B J
authors.initials: BJ
authors.lastname: Mason
authors.forename: G A
authors.initials: GA
authors.lastname: Wiesbeck
mesh_terms: D000077443:Acamprosate; D000427:Alcohol Deterrents / Q000627:therapeutic use*; D000437:Alcoholism / Q000188:drug therapy* / Q000517:prevention & control; D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods; D004195:Disease Models, Animal; D015259:Dopamine Agents / Q000627:therapeutic use; D006801:Humans; D009271:Naltrexone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D016548:Prosencephalon / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism; D055502:Secondary Prevention; D018490:Serotonin Agents / Q000627:therapeutic use; D013654:Taurine / Q000031:analogs & derivatives / Q000627:therapeutic use*
chemical_list: D000427:Alcohol Deterrents; D015259:Dopamine Agents; C121001:NR2B NMDA receptor; D009292:Narcotic Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D018490:Serotonin Agents; D013654:Taurine; D009271:Naltrexone; D000077443:Acamprosate