Domestic cat model for predicting human nucleoside analogue pharmacokinetics in blood and seminal plasma.
To establish whether a feline model can predict nucleoside analogue behavior in human semen, zidovudine (ZDV) and lamivudine (3TC) pharmacokinetic parameters (PKs) were determined in the blood and seminal plasma of healthy cats. Our results show considerable similarity in ZDV and 3TC PKs between cats and humans. As in humans, ZDV and 3TC tend to accumulate in feline seminal plasma. Area under the blood plasma concentration-time curve was predictive of seminal plasma excretion. The felid model offers a unique in vivo experimental alternative for investigating the pharmacokinetics of nucleoside analogues in the male genital tract.
Jordan
H L
HL
Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599, USA. holly_jordan@med.unc.edu
Pereira
A S
AS
Cohen
M S
MS
Kashuba
A D
AD
D000818:Animals; D019380:Anti-HIV Agents / Q000097:blood / Q000493:pharmacokinetics*; D002415:Cats; D006801:Humans; D019259:Lamivudine / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D023421:Models, Animal; D012661:Semen / Q000378:metabolism*; D015215:Zidovudine / Q000097:blood / Q000493:pharmacokinetics*
D019380:Anti-HIV Agents; D019259:Lamivudine; D015215:Zidovudine