[Effects of endothelin-1 on choroidal vessels--2. Study using indocyanine green videoangiography].
OBJECTIVE
The effects of intravenous administration of endothelin-1(ET-1) on choroidal arteries were studied using indocyanine green videoangiography.


METHODS
The changes in caliber of the choroidal arteries in eight albino rabbits were examined using indocyanine green videoangiography with a scanning laser ophthalmoscope and an image analysis system.


RESULTS
Administration of 10(-9) mol/kg of ET-1 induced a significant reduction in diameter of 50.5-80.1%(median = 64.15%) 5 minutes after administration. The constriction continued for more than 60 minutes.


CONCLUSIONS
This study demonstrates that intravenous administration of ET-1 induces long-lasting constriction of choroidal arteries. This suggests that ET-1 may participate in the regulation of choroidal artery tone.
Nakagawa
H
H
Department of Ophthalmology, Okayama University Medical School, 2-5-1 Shikata-cho, Okayama 700-8558, Japan.
D000818:Animals; D001158:Arteries / Q000187:drug effects; D002829:Choroid / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000187:drug effects*; D019332:Endothelin-1 / Q000494:pharmacology*; D007208:Indocyanine Green; D007275:Injections, Intravenous; D008297:Male; D011817:Rabbits; D011859:Radiography; D014661:Vasoconstriction; D014742:Videodisc Recording
D019332:Endothelin-1; D007208:Indocyanine Green