The bronchial epithelium in asthma--much more than a passive barrier.
The bronchial epithelium has a multifunctional role in the airway. It is actively engaged in communicating with cells of the immune and inflammatory systems, as well as secreting cytoprotective molecules and acting as a physical barrier between the internal and external milieu of the lungs. In asthma, the bronchial epithelium is often damaged, with shedding of the columnar cells into the airway lumen. This damage and ensuing repair responses are proposed to orchestrate airway remodelling via activation of myofibroblasts in the underlying lamina reticularis. This allows the two cell types to work as a trophic unit, propagating and amplifying the response at the cell surface into the submucosa. In addition to structural damage, the epithelium displays an "activated" phenotype evident by activation of transcription factors such as nuclear factor kappa B (NF kappa B), and expression of mediators which directly or indirectly lead to a chronic cycle of inflammation and injury. A diverse number of innocuous stimuli trigger asthma. It is likely that interactions between genetic and environmental factors converge on common intracellular signalling pathways that regulate epithelial stress and repair. Of particular relevance is the NF kappa B signalling pathway and the mitogen activated protein kinase pathways (MAPKs), of which the mitogen activated extracellular regulated kinases (ERKs), and the stress activated P38 and c-Jun NH2 terminal kinase (JNKs) are best known. This review aims to highlight the importance of these signalling pathways in coordinating the response to diverse stimuli at the surface of the bronchial epithelium which leads to development and maintenance of the asthmatic state.
Hamilton
L M
LM
Respiratory, Cell and Molecular Biology Division, School of Medicine, University of Southampton, Southampton General Hospital, Tremona Road, Southampton, SO16 6YD.
Davies
D E
DE
Wilson
S J
SJ
Kimber
I
I
Dearman
R J
RJ
Holgate
S T
ST
D001249:Asthma / Q000473:pathology* / Q000503:physiopathology*; D001980:Bronchi / Q000473:pathology* / Q000503:physiopathology*; D006801:Humans; D020545:Respiratory Mucosa / Q000473:pathology* / Q000503:physiopathology*; D015398:Signal Transduction / Q000502:physiology