Face off--the interplay between activating and inhibitory immune receptors.
The function of leukocytes is regulated by the integration of positive and negative signals received through cell surface receptors. Related receptors with similar extracellular domains and often binding the same ligands can transmit either inhibitory or activating signals. Studies are beginning to reveal how these 'paired receptors' control immune functions.
Lanier
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LL
Department of Microbiology and Immunology and the Cancer Research Institute, University of California (San Francisco), 513 Parnassus Avenue, Box 0414, 94143-0414, San Francisco, CA, USA. lanier@itsa.ucsf.edu
D000818:Animals; D015536:Down-Regulation / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology; D015854:Up-Regulation / Q000276:immunology*
D011971:Receptors, Immunologic