title: Effect of intratumoral OK-432 administration of thymidine phosphorylase expression in human gastric carcinoma.
abstract: It is known that thymidine phosphorylase (dThdPase) is increased in various types of malignant tumors and is induced by cytokines. In this study, we have investigated the effects of OK-432, which induces multiple cytokines, on dTHdPase expression and angiogenesis in human gastric carcinomas. We examined 25 patients who underwent gastrectomy for gastric carcinoma. OK-432 was directly injected in tumors in 16 (OK group) of 25 patients via endoscopy before operation and the other 9 patients were not treated (control group). The dThdPase activity in carcinoma tissues of the OK group was significantly higher than that of the control group (P < 0.05). The amounts of IL-1 alpha, IFN-alpha, and IFN-gamma in carcinomas in the OK group were significantly higher than in the controls (P < 0.05), and these were significantly correlated with the dThdPase activity. Intratumoral OK-432 administration enhances the expression of dThdPase in gastric carcinoma cells by inducing various cytokines.
authors.affiliation: Department of Surgery, Tokyo Women's Medical University Daini Hospital, 2-1-10 Nishioku Arakawa-ku, Tokyo 116-8567, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: S
authors.initials: S
authors.lastname: Konno
authors.forename: Y
authors.initials: Y
authors.lastname: Takebayashi
authors.forename: M
authors.initials: M
authors.lastname: Murayama
authors.forename: T
authors.initials: T
authors.lastname: Shimakawa
authors.forename: T
authors.initials: T
authors.lastname: Katsube
authors.forename: Y
authors.initials: Y
authors.lastname: Naritaka
authors.forename: T
authors.initials: T
authors.lastname: Kajiwara
authors.forename: M
authors.initials: M
authors.lastname: Aiba
authors.forename: S
authors.initials: S
authors.lastname: Akiyama
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002196:Capillaries; D005260:Female; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis; D007371:Interferon-gamma / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D008297:Male; D008875:Middle Aged; D010844:Picibanil / Q000008:administration & dosage / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000473:pathology; D013939:Thymidine Phosphorylase / Q000096:biosynthesis*
chemical_list: D000970:Antineoplastic Agents; D016898:Interferon-alpha; D007375:Interleukin-1; D010844:Picibanil; D007371:Interferon-gamma; D013939:Thymidine Phosphorylase