title: Aortic valve replacement in a patient with factor XII deficiency: case report.
abstract: Congenital factor XII deficiency is a rare condition. We report a case of aortic valve replacement (AVR) in a 63-year-old man with factor XII deficiency. On admission, the patient's activated partial thromboplastin time (aPTT) was prolonged (271 s), and activated clotting time was 500 s. His factor XII level was <3%. The Sonoclot signature showed an abnormal pattern. AVR with a prosthetic valve (St. Jude Medical) was performed safely after the normalization of aPTT and the Sonoclot signature by frozen plasma transfusion. The perioperative management in patients with factor XII deficiency is discussed.
authors.affiliation: Division of Cardiovascular Surgery, Osaka City University Medical School, Abeno, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Shibata
authors.forename: Y
authors.initials: Y
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Hosono
authors.forename: S
authors.initials: S
authors.lastname: Suehiro
authors.forename: H
authors.initials: H
authors.lastname: Kinoshita
mesh_terms: D001021:Aortic Valve / Q000601:surgery*; D001022:Aortic Valve Insufficiency / Q000150:complications* / Q000601:surgery*; D005175:Factor XII Deficiency / Q000150:complications*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D019990:Perioperative Care