title: The ubiquitin-proteasome 26s pathway in liver cell protein turnover: effect of ethanol and drugs.
abstract: This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Samuel W. French and R. J. Mayer. The presentations were (1) The ubiquitin-proteasome 26s pathway in liver cell protein turnover: Effect of alcohol and drugs, by Samuel W. French and F. Bardag-Gorce; (2) The role of CYP2E1 phosphorylation and degradation pathway in the induction of the enzyme, by Magnus Ingelman-Sundberg; (3) Role of proteasome in the proteolysis of oxidized proteins in experimental chronic alcoholism, by Helen Rouach; (4) Alcohol, proteolysis and liver cancer, by R. J. Mayer; (5) Effect of ethanol feeding on the ATP-ubiquitin-proteasome pathway in the liver cell, by F. Bardag-Gorce; (6) Novel mechanisms and targets for intracellular transport of CYP2E1, by E. Neve; and (7) Gankyrin, an oncoprotein commonly over expressed in hepatoma, by H. Higashitsuji.
authors.affiliation: Harbor-UCLA Medical Center, Torrance, California 90509, USA. French@HUMC.Edu
authors.forename: S W
authors.initials: SW
authors.lastname: French
authors.forename: R J
authors.initials: RJ
authors.lastname: Mayer
authors.forename: F
authors.initials: F
authors.lastname: Bardag-Gorce
authors.forename: M
authors.initials: M
authors.lastname: Ingelman-Sundberg
authors.forename: H
authors.initials: H
authors.lastname: Rouach
authors.forename: E
authors.initials: E
authors.lastname: Neve And
authors.forename: H
authors.initials: H
authors.lastname: Higashitsuji
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D002918:Chymotrypsin / Q000187:drug effects / Q000378:metabolism; D019392:Cytochrome P-450 CYP2E1 / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D022781:Hepatocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism; D051379:Mice; D010447:Peptide Hydrolases / Q000187:drug effects* / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D051381:Rats; D014452:Ubiquitins / Q000187:drug effects* / Q000378:metabolism
chemical_list: D002492:Central Nervous System Depressants; D014452:Ubiquitins; D000431:Ethanol; D019392:Cytochrome P-450 CYP2E1; D010447:Peptide Hydrolases; D002918:Chymotrypsin; D046988:Proteasome Endopeptidase Complex; C061553:ATP dependent 26S protease