Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.
McCubrey
J A
JA
Department of Microbiology and Immunology, Brody School of Medicine at East Carolina University, Greenville, NC 27858, USA. mccubreyj@mail.ecu.edu
Steelman
L S
LS
Blalock
W L
WL
Lee
J T
JT
Moye
P W
PW
Chang
F
F
Pearce
M
M
Shelton
J G
JG
White
M K
MK
Franklin
R A
RA
Pohnert
S C
SC
D000818:Animals; D015153:Blotting, Western; D002460:Cell Line; D016207:Cytokines / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D049452:Green Fluorescent Proteins; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D007377:Interleukin-3 / Q000378:metabolism; D007938:Leukemia / Q000378:metabolism; D008164:Luminescent Proteins / Q000378:metabolism; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D008954:Models, Biological; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins / Q000378:metabolism*; D051057:Proto-Oncogene Proteins c-akt; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism; D019908:Proto-Oncogene Proteins c-raf / Q000378:metabolism*; D012313:RNA / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D012190:Retroviridae / Q000235:genetics; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
D016207:Cytokines; D049452:Green Fluorescent Proteins; D006133:Growth Substances; D007377:Interleukin-3; D008164:Luminescent Proteins; D020930:MAP Kinase Kinase Kinases; D019950:Mitogen-Activated Protein Kinase 1; D019869:Phosphatidylinositol 3-Kinases; D017346:Protein Serine-Threonine Kinases; D011518:Proto-Oncogene Proteins; D051057:Proto-Oncogene Proteins c-akt; D019253:Proto-Oncogene Proteins c-bcl-2; D019908:Proto-Oncogene Proteins c-raf; D012313:RNA; D011993:Recombinant Fusion Proteins; D013936:Thymidine; C494918:AKT1 protein, human