Recurrent Epstein-Barr virus associated disease in a cardiac transplant patient: evolution from plasmacytic hyperplasia to diffuse large cell lymphoma.
An Epstein-Barr virus (EBV)-seronegative 31-year-old male underwent cardiac transplantation in 1991 for congenital cardiomyopathy. He presented with a protracted course of waxing and waning lymphadenopathy beginning four years after transplantation with eventual progression to a fulminant EBV-positive large cell lymphoma eight years after transplantation. Risk factors for the development of post-transplant lymphoproliferative disease in this patient, the importance of a standardized approach to pathology in assessing therapeutic options, and the management strategies used are discussed.
Larratt
L M
LM
Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. llarratt@cha.ab.ca
Hamilton
M
M
Coupland
R
R
Preiksaitis
J K
JK
D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D006965:Hyperplasia; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008297:Male; D010950:Plasma Cells / Q000473:pathology*; D012008:Recurrence