The effect of the gonadotropin-releasing hormone analog, buserelin, on pregnancy rates in horse and pony mares.
We conducted a series of trials over a four-year period on a total of 2,346 mares, to determine the effect of a single dose of the GnRH analog buserelin (20 to 40 microg i.m. or s.c.) on pregnancy rates when given between 8 and 12 days after service. Although there were some statistically significant improvements in pregnancy rates in individual trials, meta-analysis of the data overall showed significant improvements at all times examined, i.e. 13 to 16, 19 to 23, 28 to 31 and 38 to 42 days after service. These results indicate that treatment of mares with 20 to 40 microg buserelin between Days 8 and 12 significantly increases pregnancy rates by approximately 10 percentage points.
Newcombe
J R
JR
Department of Farm Animal and Equine Medicine and Surgery, Royal Veterinary College, Hatfield, Herts, UK.
Martinez
T A
TA
Peters
A R
AR
D000818:Animals; D001947:Breeding / Q000379:methods*; D002064:Buserelin / Q000008:administration & dosage / Q000494:pharmacology*; D004334:Drug Administration Schedule; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage / Q000494:pharmacology*; D006736:Horses / Q000502:physiology*; D011247:Pregnancy; D018873:Pregnancy Rate; D011270:Pregnancy, Animal / Q000187:drug effects*
D005300:Fertility Agents, Female; D002064:Buserelin