title: Abdominosacral resection for primary irresectable and locally recurrent rectal cancer.
abstract: OBJECTIVE
  The purpose of this study was to present a technique of abdominosacral resection and its results in patients with locally advanced primary or locally recurrent rectal cancer with dorsolateral fixation.
  
  
  METHODS
  Between 1994 and 1999, 13 patients with locally advanced primary rectal cancer and 37 patients with locally recurrent rectal cancer underwent abdominosacral resection as part of a multimodality treatment, i.e., preoperative irradiation, surgery, and intraoperative irradiation. After the abdominal phase, the patient was turned from supine to prone position to perform the transsacral phase of the resection.
  
  
  RESULTS
  Margins were microscopically negative in 26 patients (52 percent), microscopically positive in 18 (36 percent), and positive with gross residual disease in 6 patients. Operation time ranged from 210 to 590 (median, 390) minutes, and blood loss ranged from 400 to 10,000 (median, 3,500) ml. No operative or hospital deaths occurred. Postoperative complications occurred in 41 patients (82 percent); most notable were perineal wound infections or dehiscence (n = 24, 48 percent). Other complications were postoperative urinary retention or incontinence (n = 9, 18 percent), peritonitis (n = 4), grade II neuropathy (n = 1), and fistula formation (n = 3). Kaplan-Meier 3-year overall survival, disease-free survival, and local control rates were, respectively, 41 percent, 31 percent, and 61 percent. Completeness of the resection (negative vs. positive margins) was a significant factor influencing survival (P = 0.04), disease-free survival (P = 0.0006), and local control (P = 0.0002).
  
  
  CONCLUSIONS
  The abdominosacral resection provides wide access and may be the therapeutic solution for the accomplishment of a radical resection for distally situated, dorsally or dorsolaterally fixed primary or locally recurrent rectal cancers.
authors.affiliation: Catharina Hospital, the Department of Surgery, Eindhoven, the Netherlands.
authors.forename: G H
authors.initials: GH
authors.lastname: Mannaerts
authors.forename: H J
authors.initials: HJ
authors.lastname: Rutten
authors.forename: H
authors.initials: H
authors.lastname: Martijn
authors.forename: G J
authors.initials: GJ
authors.lastname: Groen
authors.forename: P E
authors.initials: PE
authors.lastname: Hanssens
authors.forename: T
authors.initials: T
authors.lastname: Wiggers
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012004:Rectal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012445:Sacrococcygeal Region / Q000601:surgery; D016019:Survival Analysis; D016896:Treatment Outcome; D014945:Wound Healing