title: Synthesis of new cationic lipids from an unsaturated glycoside scaffold.
abstract: [see structure]. We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicatenar derivatives. Investigation of their physicochemical properties indicated that these new compounds compact DNA.
authors.affiliation: LCBBMC UMR 7001 CNRS-ENSCP-Aventis Gencell. ENSCP 11, rue Pierre et Marie Curie 75231 Paris Cedex France. herscovi@ext.jussieu.fr
authors.forename: J
authors.initials: J
authors.lastname: Herscovici
authors.forename: M J
authors.initials: MJ
authors.lastname: Egron
authors.forename: A
authors.initials: A
authors.lastname: Quenot
authors.forename: F
authors.initials: F
authors.lastname: Leclercq
authors.forename: N
authors.initials: N
authors.lastname: Leforestier
authors.forename: N
authors.initials: N
authors.lastname: Mignet
authors.forename: B
authors.initials: B
authors.lastname: Wetzer
authors.forename: D
authors.initials: D
authors.lastname: Scherman
mesh_terms: D002412:Cations; D004247:DNA / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry*; D008055:Lipids / Q000138:chemical synthesis*; D008968:Molecular Conformation
chemical_list: D002412:Cations; D006027:Glycosides; D008055:Lipids; D004247:DNA