Drosophila Pin1 prolyl isomerase Dodo is a MAP kinase signal responder during oogenesis.
The mammalian cis-trans prolyl isomerase Pin1 and its yeast orthologue Ess1/Ptf1 have been implicated in cell cycle control but a correlation between biochemical and physiological functions has not been established conclusively. Pin1 targets the proline residue carboxy-terminal to the phosphorylated threonine or serine residue, which constitutes part of the phosphorylated mitogen-activated protein kinase (MAPK) site PXpT/SP. Here we show that the Drosophila Pin1 homologue, the Dodo protein, is involved in dorsoventral patterning of the follicular epithelium in the egg chamber. Its function is to facilitate the degradation of transcription factor CF2, which requires, a priori, activated epidermal growth factor receptor-MAPK signalling.
Hsu
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Laboratory of Cancer Genomics, Hollings Cancer Center, Medical University of South Carolina, 86 Jonathan Lucas Street, Charleston, South Carolina 29425, USA. hsut@musc.edu
McRackan
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D
Vincent
T S
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Gert de Couet
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D000818:Animals; D004268:DNA-Binding Proteins / Q000378:metabolism; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000201:enzymology* / Q000378:metabolism; D019476:Insect Proteins / Q000378:metabolism*; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D009866:Oogenesis / Q000502:physiology*; D019696:Peptidylprolyl Isomerase / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D015398:Signal Transduction; D014157:Transcription Factors / Q000378:metabolism; D014452:Ubiquitins / Q000378:metabolism
D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D019476:Insect Proteins; D000072340:NIMA-Interacting Peptidylprolyl Isomerase; D014157:Transcription Factors; D014452:Ubiquitins; C076904:Cf2 protein, Drosophila; D020928:Mitogen-Activated Protein Kinases; D019696:Peptidylprolyl Isomerase; C000606849:dod protein, Drosophila