title: Beyond kinetic traps in RNA folding.
abstract: Large RNAs often have rugged folding energy landscapes that result in severe misfolding and slow folding kinetics. Several interdependent parameters that contribute to misfolding are now well understood and examples of large RNAs and ribonucleoproteins that avoid kinetic traps have been reported. These advances have facilitated the exploration of fundamental RNA folding processes that were previously inaccessible.
authors.affiliation: Department of Molecular Biology and the Skaggs Institute for Chemical Biology, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. dtreiber@aventabio.com
authors.forename: D K
authors.initials: DK
authors.lastname: Treiber
authors.forename: J R
authors.initials: JR
authors.lastname: Williamson
mesh_terms: D005091:Exons; D007700:Kinetics; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D012261:Ribonucleoproteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D012261:Ribonucleoproteins; D012313:RNA