title: Salivary scintigraphy for assessing the protective effect of pilocarpine in head and neck irradiated tumours.
abstract: Patients with head and neck cancers can develop salivary hypofunction after radiotherapy. The use of pilocarpine during radiotherapy treatment has been shown to be an effective treatment, although its usefulness is being discussed. The aim of this study was: (1) to determine the value of a semiquantitative scintigraphy method for measuring the uptake and excretory salivary function of patients with head and neck irradiated tumours; and (2) to study the usefulness of pilocarpine as a salivary gland protector during radiotherapy. We prospectively studied 49 patients (mean age 61 years, range 29-87 years) with head and neck cancer in need of radiotherapy. Patients were divided into two groups consecutively: group P (26 patients) received 5 mg of pilocarpine three times per day starting the day before radiation therapy, and group NP (23 patients) received radiotherapy without pilocarpine and were used as the control group. Salivary gland scintigraphy and a visual analogue scale (VAS) of mouth dryness were obtained from each patient before radiotherapy and during the first year after treatment. The most frequent finding after radiotherapy was a quick impairment in parotid and submaxillary excretion (P < 0.001). There were no statistical differences comparing the pilocarpine group against the non-pilocarpine group. Parotid and submaxillary uptake significantly decreased after radiotherapy in both groups (P < 0.001). However, a tendency to recover within the pilocarpine group was observed in both the parotids and the submaxillary glands at 12 months. No differences were found comparing the VAS results in both groups. Strikingly, VAS data did not correlate with salivary gland dysfunction observed by means of scintigraphy. In conclusion, salivary scintigraphy is a useful technique to evaluate objectively the salivary gland function of patients with head and neck irradiated tumours as well as to test the response to pilocarpine. However, despite better results on the salivary uptake at 12 months, pilocarpine did not significantly improve salivary gland function.
authors.affiliation: Department of Nuclear Medicine, Hospital Clinic, University of Barcelona, Spain. 32395jmf@comb.es
authors.forename: J J
authors.initials: JJ
authors.lastname: Mateos
authors.forename: X
authors.initials: X
authors.lastname: Setoain
authors.forename: J
authors.initials: J
authors.lastname: Ferre
authors.forename: A
authors.initials: A
authors.lastname: Rovirosa
authors.forename: B
authors.initials: B
authors.lastname: Navalpotro
authors.forename: F
authors.initials: F
authors.lastname: Martin
authors.forename: M
authors.initials: M
authors.lastname: Ortega
authors.forename: F
authors.initials: F
authors.lastname: Lomeña
authors.forename: D
authors.initials: D
authors.lastname: Fuster
authors.forename: J
authors.initials: J
authors.lastname: Pavia
authors.forename: F
authors.initials: F
authors.lastname: Pons
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000150:complications* / Q000532:radiotherapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D018721:Muscarinic Agonists / Q000627:therapeutic use*; D010862:Pilocarpine / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000000981:diagnostic imaging / Q000517:prevention & control*; D011877:Radionuclide Imaging; D012466:Salivary Gland Diseases / Q000000981:diagnostic imaging / Q000517:prevention & control*; D012469:Salivary Glands / Q000000981:diagnostic imaging; D014987:Xerostomia / Q000517:prevention & control
chemical_list: D018721:Muscarinic Agonists; D010862:Pilocarpine