Monitoring solid-phase glycoside synthesis with (19)F NMR spectroscopy.
[structure: see text] A simple and efficient method for monitoring and optimizing carbohydrate synthesis on polymeric support by using (19)F NMR spectroscopy is described. The method relies on the use of fluorinated variants of protective groups that are in common use in oligosaccharide synthesis.
Mogemark
M
M
Organic Chemistry, Department of Chemistry, Umeå University, SE-901 87 Umeå, Sweden.
Elofsson
M
M
Kihlberg
J
J
D020650:Combinatorial Chemistry Techniques; D005461:Fluorine; D006027:Glycosides / Q000138:chemical synthesis / Q000737:chemistry*; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000379:methods*; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry
D006027:Glycosides; D009844:Oligosaccharides; D005461:Fluorine