title: Autologous blood injection for marked overfiltration early after trabeculectomy with mitomycin C.
abstract: OBJECTIVE
  After trabeculectomy with mitomycin C, extremely low intraocular pressure (IOP) with excess filtration may cause hypotonous maculopathy in the early postoperative period. We evaluated the effect of injecting autologous blood on reversing early postoperative marked hypotony after trabeculectomy with mitomycin C.
  
  
  METHODS
  Trabeculectomy with mitomycin C was performed in 258 eyes between 1994 and 1998. Peribleb autologous blood injection was performed in five eyes in which pressure patches were ineffective in reversing excess filtration. Approximately 0.1 to 0.3 ml of whole unclotted blood was slowly injected at least 3 mm from the edge of the flap using a sterile 27-gauge needle.
  
  
  RESULTS
  None of these eyes developed hypotonous maculopathy after injection. After a mean 31-month follow-up, all eyes had well-controlled IOP and visual acuity in three eyes was much improved. Postoperative complications included mild IOP elevation in one eye treated with laser suturelysis, and fibrinous pupillary membrane in one eye.
  
  
  CONCLUSIONS
  In the early postoperative period, autologous blood injection is effective in reversing excess filtration.
authors.affiliation: Department of Ophthalmology, Hiroshima University School of Medicine, Hiroshima, Japan. kjokada@hiroshima-u.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Tsukamoto
authors.forename: M
authors.initials: M
authors.lastname: Masumoto
authors.forename: K
authors.initials: K
authors.lastname: Jian
authors.forename: M
authors.initials: M
authors.lastname: Okada
authors.forename: H
authors.initials: H
authors.lastname: Mochizuki
authors.forename: H K
authors.initials: HK
authors.lastname: Mishima
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001082:Aqueous Humor / Q000378:metabolism; D001769:Blood; D005260:Female; D005902:Glaucoma, Open-Angle / Q000601:surgery; D006801:Humans; D007267:Injections; D007429:Intraocular Pressure; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage*; D015814:Ocular Hypotension / Q000209:etiology / Q000378:metabolism / Q000628:therapy*; D012164:Retinal Diseases / Q000517:prevention & control; D014130:Trabeculectomy / Q000009:adverse effects*
chemical_list: D016685:Mitomycin