title: Fatal rebleeding following coil embolization of cerebral aneurysms: the role of long-term systemic anticoagulation.
abstract: Embolization of cerebral aneurysms has become a common technique. Its impact on subsequent medical management of the patient is not well known. We report two patients who presented in a poor neurological grade after subarachnoid hemorrhage from posterior communicating artery aneurysms. Both were treated by coil embolization and both developed subclavian vein thrombosis, requiring systemic anticoagulation, initiated 11 and 21 days after embolization, respectively. Both developed a large, fatal intracranial hemorrhage adjacent to the embolized aneurysm in the fourth week of anticoagulation. Systemic anticoagulation of patients who have had a ruptured aneurysm treated by coil embolization may carry a significant risk of rebleeding. Alternate management strategies should be considered in these patients.
authors.affiliation: Department of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia 19104-4283, USA. sinsong@mail.med.upenn.edu
authors.forename: G
authors.initials: G
authors.lastname: Sinson
authors.forename: L J
authors.initials: LJ
authors.lastname: Bagley
authors.forename: E S
authors.initials: ES
authors.lastname: Flamm
authors.forename: R W
authors.initials: RW
authors.lastname: Hurst
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D002543:Cerebral Hemorrhage / Q000209:etiology*; D004621:Embolization, Therapeutic; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D002532:Intracranial Aneurysm / Q000628:therapy*; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors
chemical_list: D000925:Anticoagulants