title: Assessment of hemolysis related quantities in a microaxial blood pump by computational fluid dynamics.
abstract: A computational assessment or even quantification of shear induced hemolysis in the predesign phase of artificial organs (e.g., cardiac assist devices) would largely decrease efforts and costs of design and development. In this article, a general approach of hemolysis analysis by means of computational fluid dynamics (CFD) is discussed. A validated computational model of a microaxial blood pump is used for detailed analysis of shear stress distribution. Several methods are presented that allow for a qualitative assessment of shear stress distribution and related exposure times using a Lagrangian approach and mass distribution in combination with shear stress analysis. The results show that CFD offers a convenient tool for the general assessment of shear-induced hemolysis. The determination of critical regions and an estimation of the amount of blood subject to potential damage in relation to the total mass flow are shown to be feasible. However, awareness of limitations and potential flaws in CFD based hemolysis assessments is crucial.
authors.affiliation: Helmholtz Institute for Biomedical Engineering; Impella Cardiotechnik AG, Aachen, Germany. apel@hia.rwth-aachen.de
authors.forename: J
authors.initials: J
authors.lastname: Apel
authors.forename: R
authors.initials: R
authors.lastname: Paul
authors.forename: S
authors.initials: S
authors.lastname: Klaus
authors.forename: T
authors.initials: T
authors.lastname: Siess
authors.forename: H
authors.initials: H
authors.lastname: Reul
mesh_terms: D019295:Computational Biology; D003198:Computer Simulation; D006353:Heart-Assist Devices / Q000009:adverse effects*; D006461:Hemolysis / Q000502:physiology; D018056:Hemorheology; D006801:Humans; D021621:Imaging, Three-Dimensional; D008954:Models, Biological; D014783:Viscosity