[Recent trends in studies of the etiology of hypertension: New endocrine regulators of blood pressure].
The literature review reflects new aspects of humoral regulation in hypertension and target-organ damages with special regard to natriuretic peptide system(NPS) and adrenomedullin(AM). NPS and AM are recently discovered regulators which serve as antihypertensive and target-organ protective factors. These peptides have both diuretic and natriuretic properties and a relaxing effect on the vasculature. Moreover, they antagonize the proliferative and hypertrophic stimuli in the vasculature and heart. Recently, progressive technics of molecular biology clearly revealed crucial roles of these peptides for cardiovascular regulation in both normal and pathological states including hypertension and related organ damages. Natriuretic peptides, potentially AM, are new therapeutic tools for heart failure and main targets for further development of new antihypertensive drugs such as vasopeptidase inhibitor.
Kita
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T
First Department of Internal Medicine, Miyazaki Medical College.
Eto
T
T
D053607:Adrenomedullin; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology / Q000627:therapeutic use; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000209:etiology*; D020097:Natriuretic Peptide, Brain / Q000502:physiology / Q000627:therapeutic use; D010455:Peptides / Q000502:physiology
D010455:Peptides; D020097:Natriuretic Peptide, Brain; D053607:Adrenomedullin; D009320:Atrial Natriuretic Factor