Synthesis, chemical and enzymatic reactivity, and toxicity of dithymidylyl-3',5'-phosphorofluoridate and -phosphorothiofluoridate.
Dithymidylyl-3',5'-phosphorofluoridate and phosphorothiofluoridate were obtained by fluorinolysis of the P--Se bond in appropriate bisdimethoxytrityl selenomethyl esters. These compounds, which are hydrolytically unstable, are not inhibitors of snake venom, spleen phosphodiesterases and alkaline phosphatase. Neither compound is highly toxic.
Misiura
K
K
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lódz, Poland. kmisiura@bio.cbmm.lodz.pl
Szymanowicz
D
D
Kuśnierczyk
H
H
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors*; D000818:Animals; D001671:Biochemistry / Q000379:methods; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010744:Phosphoric Monoester Hydrolases / Q000037:antagonists & inhibitors*; D017553:Phosphorus Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D012910:Snake Venoms / Q000201:enzymology; D013154:Spleen / Q000201:enzymology; D013329:Structure-Activity Relationship; D013936:Thymidine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D018675:Toxicity Tests
D004791:Enzyme Inhibitors; D017553:Phosphorus Compounds; D012910:Snake Venoms; C435810:dithymidylyl-3',5'-phosphorofluoridate; C435812:dithymidylyl-3',5'-phosphorothiofluoridate; D000469:Alkaline Phosphatase; D010744:Phosphoric Monoester Hydrolases; D013936:Thymidine