title: The clinicopathologic characteristics of colorectal cancer in patients under 50 years of age: experience of an oncology center.
abstract: OBJECTIVE
  Colorectal cancer is seen mostly among patients older than 50 years of age. An aggressive behavior is a frequently cited as characteristic of colorectal cancer in young patients. The purpose of the present study was to reveal the clinicopathologic characteristics of colorectal cancer among patients under 50 years of age.
  
  
  METHODS
  Two hundred and seventy-one patients with colorectal cancer admitted to our oncology center were evaluated, and clinicopathologic findings of the young and old patients were compared. Patient gender, site distribution, tumor stage classification, lymph node involvement, metastatic site, histologic classification, histologic differentiation, family history of malignant tumors, presenting symptoms and survival rates were compared.
  
  
  RESULTS
  One hundred patients were 50 years of age or under. Clinical, histopathologic characteristics and overall survival of the two groups did not differ. A higher rate of familial cancer syndromes was detected among young patients.
  
  
  CONCLUSIONS
  The presentation and outcome of the disease in young patients do not differ from those of older patients. A significant family history of colorectal cancer in the young patients showed the need for screening whereas the outcome of metastatic disease was poor. In order to anticipate long survival, early detection and aggressive treatment is necessary.
authors.affiliation: Department of Medical Oncology, Gazi University Medical School, Beşevler, Ankara, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Günel
authors.forename: D
authors.initials: D
authors.lastname: Yamac
authors.forename: Z
authors.initials: Z
authors.lastname: Akcali
authors.forename: F
authors.initials: F
authors.lastname: Taneri
authors.forename: M
authors.initials: M
authors.lastname: Oguz
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate