title: Molecular characterization of the klebicin B plasmid of Klebsiella pneumoniae.
abstract: The nucleotide sequence of a bacteriocin-encoding plasmid isolated from Klebsiella pneumoniae (pKlebB-K17/80) has been determined. The encoded klebicin B protein is similar in sequence to the DNase pyocins and colicins, suggesting that klebicin B functions as a nonspecific endonuclease. The klebicin gene cluster, as well as the plasmid backbone, is a chimera, with regions similar to those of pore-former colicins, nuclease pyocins and colicins as well as noncolicinogenic plasmids. Similarities between pKlebB plasmid maintenance functions and those of the colicin E1 plasmid suggest that pKlebB is a member of the ColE1 plasmid replication family.
authors.affiliation: Department of Ecology and Evolutionary Biology, Yale University, New Haven, Connecticut 06520, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Riley
authors.forename: T
authors.initials: T
authors.lastname: Pinou
authors.forename: J E
authors.initials: JE
authors.lastname: Wertz
authors.forename: Y
authors.initials: Y
authors.lastname: Tan
authors.forename: C M
authors.initials: CM
authors.lastname: Valletta
mesh_terms: D000595:Amino Acid Sequence; D001430:Bacteriocins / Q000235:genetics; D001483:Base Sequence; D003087:Colicins / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D007711:Klebsiella pneumoniae / Q000235:genetics*; D008969:Molecular Sequence Data; D005810:Multigene Family; D010957:Plasmids / Q000235:genetics*; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid
chemical_list: D001430:Bacteriocins; D003087:Colicins; C019447:klebocin