Anti-inflammatory activity of Syzygium cumini bark.
The ethanolic extract of the bark of Syzygium cumini was investigated for its anti-inflammatory activity in animal models. The extract did not show any sign of toxicity up to a dose of 10.125 g/kg, p.o. in mice. Significant anti-inflammatory activity was observed in carrageenin (acute), kaolin-carrageenin (subacute), formaldehyde (subacute)-induced paw oedema and cotton pellet granuloma (chronic) tests in rats. The extract did not induce any gastric lesion in both acute and chronic ulcerogenic tests in rats. Thus, the present study demonstrated that S. cumini bark extract has a potent anti-inflammatory action against different phases of inflammation without any side effect on gastric mucosa.
Muruganandan
S
S
Division of Pharmacology and Toxicology, Indian veterinary Research Institute, -243 122 (U.P.), Izatnagar, India.
Srinivasan
K
K
Chandra
S
S
Tandan
S K
SK
Lal
J
J
Raviprakash
V
V
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005557:Formaldehyde; D005753:Gastric Mucosa / Q000187:drug effects*; D015745:Granuloma, Foreign-Body / Q000517:prevention & control*; D007616:Kaolin; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales
D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D005557:Formaldehyde; D007616:Kaolin; D002351:Carrageenan