Peptidergic correction of the effect of acute hypobaric hypoxia in pregnant rats on progeny.
Acute hypobaric hypoxia of pregnant rats led to a significant delay in body weight gain, growth and time of eye opening in newborn rat pups which was paralleled by behavioral changes. Preventive intranasal instillations of peptide mixture (semax and beta-casomorphine-7) to pregnant females prevented the effect of hypoxia on the progeny.
Maslova
M V
MV
Department of Human and Animal Morphology, Biological Faculty, M. V. Lomonosov Moscow State University, Moscow, Russia.
Zemlyanskii
K S
KS
Shkol'nikova
M V
MV
Maklakova
A S
AS
Krushinskaya
Y V
YV
Sokolova
N A
NA
Ashmarin
I P
IP
D000324:Adrenocorticotropic Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000502:physiology*; D001835:Body Weight; D004723:Endorphins / Q000494:pharmacology*; D005260:Female; D005311:Fetal Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology; D010446:Peptide Fragments / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D017450:Receptors, Opioid, mu / Q000819:agonists
D000701:Analgesics, Opioid; D004723:Endorphins; D018696:Neuroprotective Agents; D010446:Peptide Fragments; D017450:Receptors, Opioid, mu; C021968:beta-casomorphins; C048487:ACTH (4-7), Pro-Gly-Pro-; D000324:Adrenocorticotropic Hormone