title: Renal concentrating capacity test using desmopressin at bedtime.
abstract: A crossover trial was undertaken to evaluate the bedtime administration of desmopressin (Minirin) as a renal concentrating capacity test (RCCT). Medication was given intranasally as a single 20-microgram dose to 58 children ranging from 3 to 15 years of age with suspected or known renal impairment. The night-time test was shown to be a simple and effective means of assessing renal concentrating capacity. Comparison with the standard daytime test resulted in a 60 mosmol/kg higher mean osmolality in the night-time test. The results were reproducible, with a 95% confidence interval of -26 to 43 mosmol/kg. The procedure was easy to perform, with 51 of 52 patients (or their parents) preferring the night-time regimen compared with the daytime test. Night-time desmopressin therefore offers the potential of a user-friendly RCCT in patients with suspected impairment of renal tubular function.
authors.affiliation: Department of Pediatrics, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Mårild
authors.forename: A
authors.initials: A
authors.lastname: Rembratt
authors.forename: U
authors.initials: U
authors.lastname: Jodal
authors.forename: J P
authors.initials: JP
authors.lastname: Nørgaard
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018592:Cross-Over Studies; D003894:Deamino Arginine Vasopressin / Q000009:adverse effects; D005260:Female; D006801:Humans; D007671:Kidney Concentrating Ability / Q000187:drug effects*; D008297:Male; D012076:Renal Agents / Q000009:adverse effects; D015203:Reproducibility of Results; D013997:Time Factors
chemical_list: D012076:Renal Agents; D003894:Deamino Arginine Vasopressin