The chemistry and biological effects of malondialdehyde-acetaldehyde adducts.
This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Geoffrey M. Thiele and Simon Worrall. The presentations were (1) The chemistry of malondialdehyde-acetaldehyde (MAA) adducts, by Dean J. Tuma; (2) The formation and clearance of MAA adducts in ethanol-fed rats, by Simon Worrall; (3) Immune responses to MAA adducts may play a role in the development of alcoholic liver disease, by Lynell W. Klassen; (4) Unique biological responses to MAA-modified proteins that may play a role in the development and/or progression of alcoholic liver disease, by Geoffrey M. Thiele; (5) MAA-adducted bovine serum albumin activates protein kinase C and stimulates interleukin-8 release in bovine bronchial epithelial cells, by Todd A. Wyatt; and (6) An enzyme immune assay for serum antiacetaldehyde adduct antibody using low-density lipoprotein-adduct and its significance in alcoholic liver injury and ALDH2 heterozygotes, by Naruhiko Nagata.
Thiele
G M
GM
Departments of Internal Medicine, Pathology/Microbiology, University of Nebraska Medical Center, and the Omaha VA Medical Center, Omaha, Nebraska 68105, USA. GTHIELE@unmc.edu
Worrall
S
S
Tuma
D J
DJ
Klassen
L W
LW
Wyatt
T A
TA
Nagata
N
N
D000079:Acetaldehyde / Q000378:metabolism*; D000444:Aldehyde Dehydrogenase / Q000187:drug effects / Q000378:metabolism; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000818:Animals; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D018736:DNA Adducts / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism*; D051379:Mice
D002492:Central Nervous System Depressants; D018736:DNA Adducts; D000431:Ethanol; D008315:Malondialdehyde; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000079:Acetaldehyde