Compartmentalization of regulatory proteins in the cell nucleus.
The cell nucleus is increasingly recognized as a spatially organized structure. In this review, the nature and controversies associated with nuclear compartmentalization are discussed. The relationship between nuclear structure and organization of proteins involved in the regulation of RNA polymerase II-transcribed genes is then discussed. Finally, very recent data on the mobility of these proteins within the cell nucleus is considered and their implications for regulation through compartmentalization of proteins and genomic DNA are discussed.
Hendzel
M J
MJ
Department of Oncology and Cross Cancer Institute, Faculty of Medicine and Dentistry, University of Alberta, 11560 University Ave., Alta, T6G 1Z2, Edmonton, Canada. michaelh@cancerboard.ab.ca
Kruhlak
M J
MJ
MacLean
N A
NA
Boisvert
F
F
Lever
M A
MA
Bazett-Jones
D P
DP
D000107:Acetylation; D002451:Cell Compartmentation; D002467:Cell Nucleus / Q000378:metabolism*; D002843:Chromatin / Q000737:chemistry / Q000378:metabolism; D006657:Histones / Q000378:metabolism; D006801:Humans; D007399:Interphase; D009687:Nuclear Proteins / Q000378:metabolism*; D011487:Protein Conformation; D011960:Receptors, Estrogen / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism
D002843:Chromatin; D006657:Histones; D009687:Nuclear Proteins; D011960:Receptors, Estrogen; D014157:Transcription Factors