title: A quantitative assessment of the effectiveness of PRRSV vaccination in pigs under experimental conditions.
abstract: This paper presents a quantitative approach to evaluate effectiveness of vaccination under experimental conditions. We used two consecutive experimental designs to investigate whether PRRSV transmission among vaccinated pigs was reduced compared to control pigs and to estimate the reproduction parameter R. Based upon data analysis and power calculations the series of small-scale vaccination-challenge experiments ended with multiple one-to-one experiments. This new experimental design has considerable power to detect the effect of vaccination on transmission if R is close to but still above one in vaccinated pigs. The last experiment showed that transmission was not significantly reduced and the R for vaccinated pigs was estimated to be larger than 4.9. This is remarkable because duration and level of viremia were significantly reduced by vaccination.
authors.affiliation: Department of Farm Animal Health, Faculty of Veterinary Medicine, University of Utrecht, Yalelaan 7, 3584 CL Utrecht, The Netherlands. g.nodelijk@id.wag-ur.nl
authors.forename: G
authors.initials: G
authors.lastname: Nodelijk
authors.forename: M C
authors.initials: MC
authors.lastname: de Jong
authors.forename: L A
authors.initials: LA
authors.lastname: van Leengoed
authors.forename: G
authors.initials: G
authors.lastname: Wensvoort
authors.forename: J M
authors.initials: JM
authors.lastname: Pol
authors.forename: P J
authors.initials: PJ
authors.lastname: Steverink
authors.forename: J H
authors.initials: JH
authors.lastname: Verheijden
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D008297:Male; D019318:Porcine Reproductive and Respiratory Syndrome / Q000517:prevention & control* / Q000635:transmission; D019316:Porcine respiratory and reproductive syndrome virus / Q000276:immunology* / Q000302:isolation & purification; D013552:Swine / Q000821:virology; D014613:Vaccines, Attenuated / Q000627:therapeutic use; D014765:Viral Vaccines / Q000627:therapeutic use*; D014766:Viremia / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines