title: Cerebrospinal fluid concentrations of quinupristin-dalfopristin in a patient with vancomycin-resistant Enterococcus faecium [correction of faecalis] ventriculitis.
abstract: A 44-year-old man was treated successfully for vancomycin-resistant Enterococcus faecium (VREF) ventriculitis with intrathecal quinupristin-dalfopristin 1 mg, 2 mg, and 4 mg, and other intravenous antibiotics. Cerebrospinal fluid samples were collected before and after the 1-mg and 2-mg doses to determine the concentrations of quinupristin-dalfopristin and its active metabolites. Concentrations were above the minimum inhibitory concentration for VREF immediately after unclamping the extraventricular drain and were quantifiable for at least 7 hours.
authors.affiliation: University of Illinois at Chicago, 60612, USA.
authors.forename: K W
authors.initials: KW
authors.lastname: Garey
authors.forename: E
authors.initials: E
authors.lastname: Tesoro
authors.forename: V
authors.initials: V
authors.lastname: Muggia
authors.forename: O
authors.initials: O
authors.lastname: Pasquier
authors.forename: K A
authors.initials: KA
authors.lastname: Rodvold
mesh_terms: D000328:Adult; D002557:Cerebrospinal Fluid Shunts / Q000009:adverse effects; D004660:Encephalitis / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000209:etiology; D013293:Enterococcus faecalis / Q000187:drug effects; D016908:Gram-Positive Bacterial Infections / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000592:standards; D020713:Vancomycin Resistance; D014769:Virginiamycin / Q000008:administration & dosage / Q000134:cerebrospinal fluid*
chemical_list: D014769:Virginiamycin; C062940:quinupristin-dalfopristin