title: Perfusion imaging using dynamic arterial spin labeling (DASL).
abstract: Recently, a technique based on arterial spin labeling, called dynamic arterial spin labeling (DASL (Magn Reson Med 1999;41:299-308)), has been introduced to measure simultaneously the transit time of the labeled blood from the labeling plane to the exchange site, the longitudinal relaxation time of the tissue, and the perfusion of the tissue. This technique relies on the measurement of the tissue magnetization response to a time varying labeling function. The analysis of the characteristics of the tissue magnetization response (transit time, filling time constant, and perfusion) allows for quantification of the tissue perfusion and for transit time map computations. In the present work, the DASL scheme is used in conjunction with echo planar imaging at 4.7 T to produce brain maps of perfusion and transit time in the anesthetized rat, under graded hypercapnia. The data obtained show the variation of perfusion and transit time as a function of arterial pCO2. Based on the data, CO2 reactivity maps are computed. Published 2001 Wiley-Liss, Inc.
authors.affiliation: Laboratory of Functional and Molecular Imaging and NIH MRI Research Facility, National Institute for Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-1065, USA.
authors.forename: E L
authors.initials: EL
authors.lastname: Barbier
authors.forename: A C
authors.initials: AC
authors.lastname: Silva
authors.forename: S G
authors.initials: SG
authors.lastname: Kim
authors.forename: A P
authors.initials: AP
authors.lastname: Koretsky
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D001810:Blood Volume / Q000502:physiology; D001921:Brain / Q000098:blood supply*; D002245:Carbon Dioxide / Q000097:blood; D017352:Echo-Planar Imaging; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008297:Male; D008432:Mathematical Computing; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D013113:Spin Labels
chemical_list: D013113:Spin Labels; D002245:Carbon Dioxide