Regioselective palladium-catalyzed arylation of 2-furaldehyde.
An efficient regioselective method for the direct arylation of 2-furaldehyde to provide a range of pi-diverse 5-aryl-2-formylfuran derivatives is described. The method employs functionalized aryl halides and a catalytic amount of palladium(II) chloride under relatively mild conditions.
McClure
M S
MS
GlaxoSmithKline, Chemical Development, Five Moore Drive, P.O. Box 13398, Research Triangle Park, North Carolina 27709, USA. msm81971@gsk.com
Glover
B
B
McSorley
E
E
Millar
A
A
Osterhout
M H
MH
Roschangar
F
F
D000478:Alkylation; D002384:Catalysis; D005662:Furaldehyde / Q000737:chemistry*; D007202:Indicators and Reagents; D010165:Palladium / Q000737:chemistry*; D010944:Plants / Q000737:chemistry
D007202:Indicators and Reagents; D010165:Palladium; D005662:Furaldehyde