title: Prostaglandin analog mechanisms are not effective in refractory chronic cluster headache.
abstract: Prostaglandin E analogs have been shown to be effective in the treatment of refractory trigeminal neuralgia in patients with multiple sclerosis. Prostaglandin E inhibits the functions of T lymphocytes which are involved in the pathophysiology of cluster headache. Therefore, a double-blind, placebo-controlled, crossover study on the efficacy of misoprostol in chronic refractory cluster headache was performed. Eight patients were treated with 600 micrograms misoprostol and with placebo for a 2-week period. No differences in attack frequency, intensity, global impression, and side effects could be detected, suggesting that prostaglandin E analogs are not effective in the treatment of chronic cluster headache.
authors.affiliation: Department of Neurology, University of Münster, Albert-Schweitzer-Str. 33, D-48129 Münster, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Evers
authors.forename: H
authors.initials: H
authors.lastname: Masur
authors.forename: P
authors.initials: P
authors.lastname: Sörös
authors.forename: R
authors.initials: R
authors.lastname: Brilla
authors.forename: I W
authors.initials: IW
authors.lastname: Husstedt
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003027:Cluster Headache / Q000188:drug therapy* / Q000517:prevention & control; D018592:Cross-Over Studies; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008875:Middle Aged; D016595:Misoprostol / Q000627:therapeutic use*; D010148:Intractable Pain / Q000188:drug therapy*
chemical_list: D016595:Misoprostol