title: High-dose loratadine exposure in a six-year-old child.
abstract: Loratadine is a long-acting antihistamine indicated for the treatment of seasonal allergic rhinitis and chronic idiopathic urticaria in patients 6 years of age and older. The literature contains little information on high-dose loratadine exposures; as a consequence, poison centers are unsure of the loratadine dose that can be managed with observation and the dose that requires treatment. We report an intentional ingestion of 300 mg loratadine by a 6-y-old child that resulted in minor elevation of blood pressure and heart rate when managed with supportive care only. Further studies and case series are needed before a minimum toxic dose can be established.
authors.affiliation: University of Texas Health Science Center San Antonio, South Texas Poison Center, 78229-3900, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Cobb
authors.forename: W A
authors.initials: WA
authors.lastname: Watson
authors.forename: M C
authors.initials: MC
authors.lastname: Fernández
mesh_terms: D018926:Anti-Allergic Agents / Q000506:poisoning*; D002648:Child; D062787:Drug Overdose / Q000628:therapy; D005260:Female; D006634:Histamine H1 Antagonists / Q000506:poisoning*; D006801:Humans; D017336:Loratadine / Q000506:poisoning*; D011039:Poison Control Centers; D016896:Treatment Outcome
chemical_list: D018926:Anti-Allergic Agents; D006634:Histamine H1 Antagonists; D017336:Loratadine