The Dual Role of Nitric Oxide in Islet beta-Cells.
In pancreatic islets, nitric oxide (NO) produced on exposure to cytokines mediates beta-cell injury leading to diabetes mellitus. On the other hand, L-arginine-derived NO may participate in the signal transduction pathway of physiological insulin secretion. This review focuses on the dual role of NO as a mediator of physiological and pathophysiological processes in pancreatic islets.
Spinas
Giatgen A.
GA
Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, CH-8091 Zürich, Switzerland.