Olmsted syndrome.
Olmsted syndrome is an uncommon inherited disorder of keratinization that presents mutilating palmoplantar keratoderma, perioral hyperkeratosis, leukokeratosis and alopecia. We report a case of this rare syndrome diagnosed in a 48-year-old woman and confirms the existence of a generalized abnormality in keratin expression. Immunoreactivity in our case suggests an abnormal expression of keratins 5 and 14 similar to the observed in other hyperproliferative disorders.
Fonseca
E
E
Department of Dermatology, Hospital Juan Canalejo, La Coruña, Spain. fonseca@canalejo.org
Peña
C
C
Del Pozo
J
J
Almagro
M
M
Yebra
M T
MT
Cuevas
J
J
Contreras
F
F
D000015:Abnormalities, Multiple / Q000378:metabolism / Q000473:pathology*; D000505:Alopecia / Q000378:metabolism / Q000473:pathology*; D000911:Antibodies, Monoclonal; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism; D007645:Keratoderma, Palmoplantar / Q000378:metabolism / Q000473:pathology*; D007972:Leukoplakia, Oral / Q000378:metabolism / Q000473:pathology*; D008875:Middle Aged; D012867:Skin / Q000378:metabolism / Q000473:pathology; D013577:Syndrome
D000911:Antibodies, Monoclonal; D007633:Keratins