[Fibronectin content in the urine of patients with chronic glomerulonephritis as a test for the efficiency of treatment].
Renal fibronectin synthesis is impaired in patients with chronic glomerulonephritis. We measured urinary fibronectin for evaluating the efficiency of various methods of treatment. Traditional therapy of patients with the nephrotic syndrome at the stage of renal failure leads to decrease of fibronectinuria, which can be indicative of the progress of nephrosclerotic process in the renal parenchyma; monotherapy with wobenzyme during the azothemic stage of disease in patients with the urinary and nephrotic syndrome does not cause statistically significant changes in the level of urinary fibronectin, which can be regarded as inhibition of nephrosclerosis process. Hence, wobenzyme is the drug of choice, decreasing the velocity of nephrosclerotic processes, when pathogenetic therapy is largely limited or precluded. Combination of wobenzyme with pathogenetic drugs in patients with the nephrotic syndrome and intact renal function suppresses fibronectinuria due to mutual potentiation of the antiinflammatory effect. Decrease of fibronectin concentration in the urine after wobenzyme monotherapy in patients with the urinary syndrome without signs of chronic renal insufficiency confirms the antiinflammatory effect of the drug.
Mukhin
I V
IV
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D015415:Biomarkers; D002908:Chronic Disease; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D005353:Fibronectins / Q000652:urine*; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000652:urine*; D006801:Humans; D006867:Hydrolases / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012431:Rutin / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D015415:Biomarkers; D004338:Drug Combinations; D005353:Fibronectins; D012431:Rutin; C023295:Wobenzym; D006867:Hydrolases