title: Two procedures establishing preference for oral cocaine and lidocaine solutions which do not use an associative history with a reinforcer.
abstract: Groups of rats were exposed to daily, 3-h, fixed-time 1-min food-pellet delivery sessions, a procedure that produces overdrinking (schedule-induced polydipsia, SIP). Previous research demonstrated that rats drinking a drug or non-drug solution come to prefer that solution to water if the solution had (a) a past association with either a highly acceptable vehicle (e.g. glucose/saccharin), or (b) allowed rats to eschew drinking an unacceptable solution under SIP conditions. The present experiments show that under the solution-avoidance procedure, preference for a concurrent, alternative solution (0.19 mg/ml lidocaine or 0.24 mg/ml cocaine) occurred when a concentrated quinine solution alternative was either abruptly removed or faded. A concentrated cocaine solution, however, was minimally effective in producing a preference for 0.19 mg/ml lidocaine to water when cocaine concentration was faded. Flavor/nutrient-conditioning (conditioned reinforcement) and solution-eschewing (avoidance) procedures may throw light on the kinds of historical situations that determine the genesis of stable preferences for drugs and other substances.
authors.affiliation: Department of Psychology, Rutgers University, Piscataway, NJ 08854-8020, USA. JFALK@rci.rutgers.edu
authors.forename: J L
authors.initials: JL
authors.lastname: Falk
authors.forename: K
authors.initials: K
authors.lastname: D'Mello
authors.forename: C E
authors.initials: CE
authors.lastname: Lau
mesh_terms: D000818:Animals; D001245:Association Learning / Q000187:drug effects*; D002755:Choice Behavior / Q000187:drug effects; D003042:Cocaine / Q000494:pharmacology*; D003214:Conditioning, Classical / Q000187:drug effects*; D004326:Drinking / Q000187:drug effects*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D009042:Motivation; D011803:Quinine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D012646:Self Administration; D013649:Taste / Q000187:drug effects*
chemical_list: D008012:Lidocaine; D011803:Quinine; D003042:Cocaine