title: Unraveling the Mystery of Goldblatt Hypertension.
abstract: In hypertension caused by unilateral renal artery stenosis, the nonstenotic kidney becomes renin depleted but fails to prevent hypertension. The nonstenotic kidney mysteriously develops elevated intrarenal angiotensin II (ANG II) content. Rats chronically infused with ANG II exhibit a similar hypertensive process. The augmentation of intrarenal ANG II is due to receptor-mediated internalization and continued ANG II formation, which provide a hypertensinogenic stimulus.
authors.affiliation: Dept. of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
authors.forename: L. Gabriel
authors.initials: LG
authors.lastname: Navar
authors.forename: Lixian
authors.initials: L
authors.lastname: Zou
authors.forename: Annette
authors.initials: A
authors.lastname: Von Thun
authors.forename: Chi
authors.initials: C
authors.lastname: Tarng Wang
authors.forename: John D.
authors.initials: JD
authors.lastname: Imig
authors.forename: Kenneth D.
authors.initials: KD
authors.lastname: Mitchell