title: Transcription of essential cell division genes is linked to chromosome replication in Escherichia coli.
abstract: Cell division normally follows the completion of each round of chromosome replication in Escherichia coli. Transcription of the essential cell division genes clustered at the mra region is shown here to depend on continuing chromosomal DNA replication. After chromosome replication was blocked by either nalidixic acid treatment or thymine starvation, the transcription of these cell division genes was repressed significantly. This suggests a way in which cell division is controlled by chromosome replication.
authors.affiliation: Institute of Cell and Molecular Biology, University of Edinburgh, Darwin Building, King's Buildings, Edinburgh EH9 3JR, UK. Guowen.liu@yale.edu
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: K
authors.initials: K
authors.lastname: Begg
authors.forename: A
authors.initials: A
authors.lastname: Geddes
authors.forename: W D
authors.initials: WD
authors.lastname: Donachie
mesh_terms: D001426:Bacterial Proteins / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects / Q000235:genetics; D002876:Chromosomes, Bacterial; D003598:Cytoskeletal Proteins; D003599:Cytoskeleton / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D004926:Escherichia coli / Q000166:cytology* / Q000187:drug effects / Q000235:genetics*; D029968:Escherichia coli Proteins; D005810:Multigene Family; D009154:Mutation; D009268:Nalidixic Acid / Q000494:pharmacology; D011401:Promoter Regions, Genetic; D011938:Rec A Recombinases / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D012269:Ribosomal Proteins / Q000187:drug effects / Q000235:genetics; D013936:Thymidine / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D003598:Cytoskeletal Proteins; D029968:Escherichia coli Proteins; C071525:FtsZ protein, Bacteria; D012269:Ribosomal Proteins; C027624:ribosomal protein L11; C053139:sulA protein, E coli; D009268:Nalidixic Acid; D011938:Rec A Recombinases; D013936:Thymidine