Relevance and reproducibility of patch-test reactions to corticosteroids.
We present our patch test findings with dermatocorticosteroids during the period 1995-1999. We retrospectively studied the % of doubtful and positive reactions to each allergen in our corticosteroid series and assessed the relevance of these reactions. To assess reproducibility, we retested 15 patients with doubtful or positive reactions in 1999. The % of + or ++ reactions on D2-D3 and D7 ranged from 0.0% to 0.9% for most of the compounds tested. Hydrocortisone acetate 1% alc.abs./DMSO 50/50 showed a much higher % of positive reactions. Most of these reactions were not relevant and therefore probably due to the irritant nature of the vehicle. An overall reproducibility of 47.2% was obtained. 100.0% of the non-reproducible patch test reactions were not relevant. Definite relevance was much higher in the reproducible + or ++ reactions than in the reproducible doubtful reactions: 100.0% and 18.2%, respectively. We conclude that the mean % of + and ++ reactions to the corticosteroid series on D2-D3 is 0.5%, with an overall reproducibility of 47.2%. Tixocortol pivalate and budesonide proved to be important markers for dermatocorticosteroid allergy.
Devos
S A
SA
Department of Dermatology, University Medical Center, Nijmegen, The Netherlands.
Van Der Valk
P G
PG
D000287:Administration, Topical; D000485:Allergens / Q000009:adverse effects*; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology; D005938:Glucocorticoids; D006801:Humans; D010328:Patch Tests / Q000592:standards*; D015203:Reproducibility of Results; D012867:Skin / Q000187:drug effects / Q000473:pathology
D000485:Allergens; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids