Renal Proximal Tubular Albumin Reabsorption: Daily Prevention of Albuminuria.
Although the glomerular filtration coefficient of albumin is small, the daily filtered load can be as much as 8 g. To prevent such massive losses of albumin, quantitative reabsorption along the proximal tubules is accomplished by "receptor"-mediated endocytosis. Albumin reaches the lysosomes where it is degraded to amino acids.
Gekle
Michael
M
Physiologisches Institut, Universität Würzburg, Röntgenring 9, 97070 Würzburg, Germany.