Determination of three nitroimidazole residues in poultry meat by gas chromatography with nitrogen-phosphorus detection.
A method was developed for the determination of the nitroimidazole compounds dimetridazole (DMZ), ronidazole (RNZ) and metronidazole (MNZ) by gas chromatography with nitrogen phosphorus detection. Nitroimidazole compounds were extracted with acetonitrile, followed by acidification using acetic acid and cleanup using strong cation-exchange (SCX) SPE column. Validation in chicken muscle fortified at a concentration of 5 microg/kg gave mean recoveries of 85% DMZ, 90% RNZ, 80% MNZ with RSDs of 13.0, 14.3, 11.2%, respectively (n=6). The method is suitable for statutory residue testing and is used as a quick screening method in the National Residue Surveillance Plan in China.
Wang
J H
JH
Laboratory of Food Inspection, Qingdao Exit-Entry Inspection and Quarantine Bureau, Shandong, China. wangjianhua9@yahoo.com
D000981:Antiprotozoal Agents / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods*; D004131:Dimetridazole / Q000032:analysis*; D004350:Drug Residues / Q000032:analysis*; D008795:Metronidazole / Q000032:analysis*; D009584:Nitrogen; D010758:Phosphorus; D011202:Poultry Products / Q000032:analysis*; D015203:Reproducibility of Results; D012385:Ronidazole / Q000032:analysis*
D000981:Antiprotozoal Agents; D008795:Metronidazole; D010758:Phosphorus; D012385:Ronidazole; D004131:Dimetridazole; D009584:Nitrogen