From Genetically Altered Mice to Integrative Physiology.
Transgenic and gene-targeted mice permit the study of the function(s) of the single gene(s) in a whole organism, thereby relating molecular biology and integrative physiology. To demonstrate the potential of transgenic models, we present in this review some physiologically relevant information obtained from genetically engineered mice.
Gassmann
Max
M
Institute of Physiology, University of Zürich-Irchel, CH-8057 Zürich, Switzerland.
Hennet
Thierry
T