title: Protective and susceptible HLA polymorphisms in IgA nephropathy patients with end-stage renal failure.
abstract: Idiopathic immunoglobulin A (IgA) nephropathy is characterised by an extreme variability in clinical course, leading to end-stage renal failure in 15-20% of adults. This subgroup of patients with IgA nephropathy is usually included in the waiting lists of organ exchange organisations. The frequency of HLA-A,B,DR antigens of this subset of IgA nephropathy patients was calculated and compared to controls. The antigens HLA-B35 and DR5 were significantly increased in the patients with relative risk values of 1.385 and 1.487, respectively. The antigens HLA-B7, B8, DR2, and DR3 were found in a significantly lower frequency in the patients as compared to the controls. The relative risk (RR) values ranged between 0.695 and 0.727. Consequently, the haplotypes HLA-A1, B8, DR3, HLA-A3, B7, DR2, HLA-A2, B7, DR2 together with HLA-A1, B15, DR4, HLA-A9, B12, DR7, and HLA-A10, B18, DR2 were found to be protective with RR values ranging from 0.309 to 0.587. The only susceptible haplotype observed was HLA-A2-B5, DR5 (RR=2.990).
authors.affiliation: Department of Immunohaematology and Blood Transfusion, Leiden University Medical Center, Leiden, The Netherlands. doxiadis@lumc.nl
authors.forename: I I
authors.initials: II
authors.lastname: Doxiadis
authors.forename: P
authors.initials: P
authors.lastname: De Lange
authors.forename: E
authors.initials: E
authors.lastname: De Vries
authors.forename: G G
authors.initials: GG
authors.lastname: Persijn
authors.forename: F H
authors.initials: FH
authors.lastname: Claas
mesh_terms: D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D005922:Glomerulonephritis, IGA / Q000235:genetics* / Q000276:immunology*; D006680:HLA Antigens / Q000235:genetics*; D015797:HLA-B35 Antigen / Q000235:genetics; D015793:HLA-B7 Antigen / Q000235:genetics; D015795:HLA-B8 Antigen / Q000235:genetics; D015802:HLA-DR2 Antigen / Q000235:genetics; D015803:HLA-DR3 Antigen / Q000235:genetics; D015805:HLA-DR5 Antigen / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D007676:Kidney Failure, Chronic / Q000235:genetics* / Q000276:immunology*; D011110:Polymorphism, Genetic / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D015797:HLA-B35 Antigen; D015793:HLA-B7 Antigen; D015795:HLA-B8 Antigen; D015802:HLA-DR2 Antigen; D015803:HLA-DR3 Antigen; D015805:HLA-DR5 Antigen