The promise and reality of nitric oxide in the diagnosis and treatment of lung disease.
Endogenously produced nitric oxide plays a major role in lung physiology and pathology. Inhaled nitric oxide given exogenously has been studied extensively as a treatment for many lung diseases, and the results suggest that it may help improve oxygenation in some patients. Several issues need to be addressed, however, before it can be used in routine clinical practice.
Dweik
R A
RA
Department of Pulmonary and Critical Care Medicine, Cleveland Clinic Foundation, OH 44195, USA. dweikr@ccf.org
D000532:Altitude Sickness / Q000188:drug therapy; D001249:Asthma / Q000378:metabolism; D002648:Child; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy; D007231:Infant, Newborn; D008168:Lung / Q000502:physiology; D008171:Lung Diseases / Q000188:drug therapy* / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism* / Q000627:therapeutic use*; D011654:Pulmonary Edema / Q000188:drug therapy; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy / Q000378:metabolism
D009569:Nitric Oxide