title: Role of the M1 receptor in regulating circadian rhythms.
abstract: Cholinergic stimuli are potent regulators of the circadian clock in the hypothalamic suprachiasmatic nucleus (SCN). Using a brain slice model, we have found that the SCN clock is subject to muscarinic regulation, a sensitivity expressed only during the night of the clock's 24-h cycle. Pharmacological and signal transduction characteristics are compatible with a response mediated by an M1-like receptor. Molecular manipulation of muscarinic receptors will provide important insights as to the receptor subtype(s) regulating circadian rhythms.
authors.affiliation: Department of Cell & Structural Biology, University of Illinois at Urbana-Champaign, 61801, USA. mgillett@uiuc.edu
authors.forename: M U
authors.initials: MU
authors.lastname: Gillette
authors.forename: G F
authors.initials: GF
authors.lastname: Buchanan
authors.forename: L
authors.initials: L
authors.lastname: Artinian
authors.forename: S E
authors.initials: SE
authors.lastname: Hamilton
authors.forename: N M
authors.initials: NM
authors.lastname: Nathanson
authors.forename: C
authors.initials: C
authors.lastname: Liu
mesh_terms: D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D018679:Cholinergic Agonists / Q000494:pharmacology; D002940:Circadian Rhythm / Q000502:physiology*; D006152:Cyclic GMP / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008954:Models, Biological; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D043643:Receptor, Muscarinic M1; D011976:Receptors, Muscarinic / Q000378:metabolism*; D015398:Signal Transduction; D013493:Suprachiasmatic Nucleus / Q000187:drug effects / Q000502:physiology*
chemical_list: D018679:Cholinergic Agonists; D018727:Muscarinic Antagonists; D043643:Receptor, Muscarinic M1; D011976:Receptors, Muscarinic; C016276:8-bromocyclic GMP; D002217:Carbachol; D006152:Cyclic GMP