title: Radiofrequency tissue ablation: physical principles and techniques for increasing coagulation necrosis.
abstract: Radiofrequency tumor ablation has been demonstrated as a reliable method for creating thermally-induced coagulation necrosis using either a percutaneous approach with image-guidance or direct surgical placement of thin electrodes into tissues to be treated. Early clinical trials with this technology have studied the treatment of hepatic, cerebral, and bony malignancies. The extent of coagulation necrosis induced with conventional monopolar radiofrequency electrodes is dependent on overall energy deposition, the duration of radiofrequency application, and radiofrequency electrode tip length and gauge. This article will discuss these technical considerations with the goal of defining optimal parameters for radiofrequency ablation. Strategies to further increase induced coagulation necrosis including: multiprobe and bipolar arrays, and internally-cooled radiofrequency electrodes, with or without pulsed-radiofrequency or cluster technique will be presented. The development and laboratory results for many of these radiofrequency techniques and potential biophysical limitations to radiofrequency induced coagulation, such as perfusion mediated tissue cooling (vascular flow) will likewise be discussed.
authors.affiliation: Minimally Invasive Therapies Laboratory, Department of Radiology, Beth Israel Deaconess Medical Center, 330 Brookline Avenue, Boston, MA 02215, USA. sgoldber@caregroup.harvard.edu
authors.forename: S N
authors.initials: SN
authors.lastname: Goldberg
authors.forename: G S
authors.initials: GS
authors.lastname: Gazelle
mesh_terms: D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D015179:Colorectal Neoplasms / Q000601:surgery*; D004564:Electrocoagulation / Q000379:methods*; D004566:Electrodes; D004867:Equipment Design; D006801:Humans; D009336:Necrosis; D009369:Neoplasms / Q000601:surgery*