title: Reduced regional [14C]2-deoxyglucose uptake in response to long-term clozapine administration in rats.
abstract: Clozapine has superior effects in treating negative symptoms of schizophrenia and causes less extrapyramidal side effects than traditional antipsychotics. In this study, we investigated the effects of acute and long-term clozapine administration on [14C]2-deoxyglucose uptake (2-DG uptake) in rats, as measured using the [14C]2-deoxy-D-glucose method. The 2-DG uptake was reduced in fewer regions after chronic clozapine (46%) than after acute clozapine (97%). After chronic clozapine treatment, the 2-DG uptake was reduced in the shell, but not the core, of the nucleus accumbens. In addition, long-term clozapine treatment remained affecting 2-DG uptake in several regions of the extrapyramidal system and the thalamus. The pattern of 2-DG uptake changes after long-term clozapine administration may provide information for the regions related to the therapeutic effect of clozapine.
authors.affiliation: Department of Psychiatry, Veterans General Hospital-Taipei, Taiwan, ROC. sjtsai@vghtpe.gov.tw
authors.forename: S J
authors.initials: SJ
authors.lastname: Tsai
authors.forename: Y H
authors.initials: YH
authors.lastname: Huang
authors.forename: H J
authors.initials: HJ
authors.lastname: Huang
authors.forename: C B
authors.initials: CB
authors.lastname: Sim
mesh_terms: D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001931:Brain Mapping; D003024:Clozapine / Q000494:pharmacology*; D003847:Deoxyglucose / Q000378:metabolism*; D005116:Extrapyramidal Tracts / Q000187:drug effects / Q000378:metabolism; D008134:Long-Term Care; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013788:Thalamus / Q000187:drug effects / Q000378:metabolism
chemical_list: D003847:Deoxyglucose; D003024:Clozapine