Gene therapy: a novel method for the treatment of myocardial ischemia and reperfusion injury--mini-review.
Myocardial ischemia and reperfusion injury (MI/R) represents important sequelae of clinical events. Historically, a number of approaches including, surgical intervention, pharmacological therapy and physical exercise regimes have been prescribed for the treatment of patients with cardiovascular disease. Recently, however, attention has focused upon more novel approaches using gene-based therapies to treat cardiovascular and MI/R. This mini-review will examine the role that heat shock proteins (HSP), in particular the HSP70 family, and the antiapoptotic protein Bcl-2 play in myocardial protection. Also examined in this review are several techniques including adenovirus and Japan-Liposomal method for delivering genes into the myocardium.
Li
F
F
Department of Anesthesiology, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
Hayes
J K
JK
Wong
K C
KC
D019254:Genes, bcl-2; D015316:Genetic Therapy; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D006801:Humans; D008081:Liposomes; D017202:Myocardial Ischemia / Q000628:therapy*; D015428:Myocardial Reperfusion Injury / Q000628:therapy*; D011494:Protein Kinases / Q000378:metabolism; D019831:Sodium-Calcium Exchanger / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism
D006360:Heat-Shock Proteins; D008081:Liposomes; D019831:Sodium-Calcium Exchanger; D014157:Transcription Factors; D011494:Protein Kinases