title: Anger inhibition potentiates the association of high end-tidal CO2 with blood pressure in women.
abstract: OBJECTIVE
  High resting end-tidal CO2 (PetCO2) has been shown to be an independent predictor of systolic blood pressure (SBP) in women, particularly older women. The study reported in this article investigated whether the tendency to experience, express, and/or suppress anger contributes to the association of PetCO2 and SBP in women and in men.
  
  
  METHODS
  The Spielberger Anger Expression Inventory was administered to 403 healthy male and female participants in the Baltimore Longitudinal Study on Aging. Resting PetCO2 was obtained by means of a respiratory gas monitor, and resting blood pressure was obtained with an oscillometric device. The associations of resting PetCO2 and the anger scales with SBP and diastolic blood pressure (DBP) were investigated using multivariate regression analyses.
  
  
  RESULTS
  PetCO2, as well as age and body mass index, was an independent predictor of SBP in women with low, but not high, trait anger and in women with low, but not high, anger-out. PetCO2 was not an independent predictor of SBP in men with either high or low anger. In addition, PetCO2 was not an independent predictor of DBP in either men or women.
  
  
  CONCLUSIONS
  The results of this study indicate that inhibition of anger potentiates the relationship of high PetCO2 with SBP in women but not men. Additional studies are needed to determine the origins of the observed gender differences and the psychophysiological pathways by which high resting PetCO2 contributes to elevated resting blood pressure in women.
authors.affiliation: Laboratory of Cardiovascular Sciences, National Institute on Aging, Baltimore, Maryland 21224, USA.
authors.forename: A
authors.initials: A
authors.lastname: Scuteri
authors.forename: D
authors.initials: D
authors.lastname: Parsons
authors.forename: M A
authors.initials: MA
authors.lastname: Chesney
authors.forename: D E
authors.initials: DE
authors.lastname: Anderson
mesh_terms: D000328:Adult; D000786:Anger; D015992:Body Mass Index; D002245:Carbon Dioxide / Q000097:blood*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007266:Inhibition, Psychological
chemical_list: D002245:Carbon Dioxide