Isoform-Specific Regulation of the Na(+)-K(+) Pump in Heart.
Guinea pig ventricular myocytes coexpress two isoforms of the Na(+)-K(+) pump. These two isoforms respond differently to the physical environment and are coupled to autonomic input through different signal transduction cascades. The expression of different isoforms provides each cell type with a mechanism of programming specific responses to environmental changes.
Mathias
R. T.
RT
Department of Physiology and Biophysics and Institute of Molecular Cardiology, State University of New York at Stony Brook, Stony Brook, New York 11794-8661.
Cohen
I. S.
IS
Gao
J.
J
Wang
Y.
Y