title: Cost of immunization with a locally produced, oral cholera vaccine in Viet Nam.
abstract: Policy decisions regarding whether to incorporate new vaccines into routine public health practice in developing countries will depend in part on the costs of vaccine purchase and of vaccine delivery. In March, 1997, a large-scale effectiveness trial of a locally produced, orally administered bivalent vaccine against Vibrio cholerae 01 and 0139 began in Viet Nam. Empirical data obtained from the trial was used to determine the costs of the immunization campaign from the government perspective. The study population, including the children less than one year of age and pregnant women who were ineligible for immunization, was 353926. A total of 289041 persons received two doses of vaccine, and 13340 persons received one dose of vaccine. Two-dose vaccine coverage was 83.4%. The total cost of vaccine delivery during the immunization campaign was $66527. The cost of each dose of vaccine was $0.31. Therefore, the total cost of the immunization campaign was $0.44 per dose administered, and $0.91 per fully immunized person. Attempts to reduce the cost per dose of vaccine (e.g. the use of a monovalent vaccine against serogroup 01) are likely to have a large impact on the cost of future similar immunization campaigns.
authors.affiliation: Epidemiology Branch, National Institute of Child Health and Human Development, 6100 Executive Blvd., Suite 7B03, Rockville, MD 20852, USA. an38i@nih.gov
authors.forename: A B
authors.initials: AB
authors.lastname: Naficy
authors.forename: D D
authors.initials: DD
authors.lastname: Trach
authors.forename: N T
authors.initials: NT
authors.lastname: Ke
authors.forename: N T
authors.initials: NT
authors.lastname: Chuc
authors.forename: A
authors.initials: A
authors.lastname: Sorkin
authors.forename: M R
authors.initials: MR
authors.lastname: Rao
authors.forename: T H
authors.initials: TH
authors.lastname: Sy
authors.forename: V D
authors.initials: VD
authors.lastname: Thiem
authors.forename: D G
authors.initials: DG
authors.lastname: Canh
authors.forename: R T
authors.initials: RT
authors.lastname: Mahoney
authors.forename: J
authors.initials: J
authors.lastname: Holmgren
authors.forename: B
authors.initials: B
authors.lastname: Ivanoff
authors.forename: J D
authors.initials: JD
authors.lastname: Clemens
mesh_terms: D000284:Administration, Oral; D022121:Cholera Vaccines / Q000008:administration & dosage / Q000096:biosynthesis / Q000191:economics*; D006801:Humans; D017589:Immunization Programs / Q000191:economics*; D014186:Transportation / Q000191:economics; D014744:Vietnam
chemical_list: D022121:Cholera Vaccines