Helper T cell differentiation, inside and out.
The past year has seen remarkable progress in the field of helper T cell differentiation, including discovery of a novel transcription factor as well as a novel cytokine receptor of the Th1 lineage. The year has also brought new perspectives on the genetic and epigenetic control of gene expression. It is likely that mechanisms of immunity will continue to provide insight into the general problem of cellular decision-making.
Reiner
S L
SL
Abramson Family Cancer Research Institute and Department of Medicine, 421 Curie Boulevard, Room 414, University of Pennsylvania, 19104, Philadelphia, PA, USA. sreiner@mail.med.upenn.edu
D000818:Animals; D002453:Cell Cycle / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D018417:Th1 Cells / Q000166:cytology* / Q000276:immunology; D018418:Th2 Cells / Q000166:cytology* / Q000276:immunology