Recent progress in gene delivery using non-viral transfer complexes.
The delivery of genetic material into cells is a field that is expanding very rapidly. Non-viral delivery methods, especially ones that focus on the use of chemical agents complexed with genetic material, are the focus of this mini-review. More-recent uses of known transfection agents such as poly(ethylenimine), poly(L-lysine), and various liposomes are discussed, and some novel approaches (both chemical and methodical) are reviewed as well. A very brief look at how non-viral gene delivery research is being aimed at the clinic is also included.
Godbey
W T
WT
Department of Bioengineering, Rice University, P.O. Box 1892, MS 142, Houston, TX 77251-1892, USA.
Mikos
A G
AG
D000818:Animals; D015316:Genetic Therapy / Q000379:methods* / Q000639:trends*; D006801:Humans; D008081:Liposomes; D014162:Transfection / Q000379:methods*
D008081:Liposomes