Enhanced fungicidal activity of N-chlorotaurine in nasal secretion.
The antifungal activity of N-chlorotaurine (NCT), a long-lived oxidant produced by stimulated human leucocytes, was investigated. Incubation of Aspergillus spp., Candida spp., Fusarium spp., Penicillium spp. and Alternaria spp. in 1% NCT (55 mM) for 1-4 h produced a log10 reduction in cfu of between 1 and 4. In samples of nasal secretion, killing was significantly hastened (30 min), which may be explained by the formation of monochloramine by halogenation of ammonium, which was found at a concentration of 1 mM in these samples. For these reasons, NCT is of interest as a new agent for treatment of local inflammatory mycosis, e.g. eosinophilic fungal rhinosinusitis.
Nagl
M
M
Institute of Hygiene and Social Medicine, Leopold-Franzens-University of Innsbruck, Fritz-Pregl-Strasse 3, A-6010 Innsbruck, Austria. m.nagl@uibk.ac.at
Lass-Flörl
C
C
Neher
A
A
Gunkel
A
A
Gottardi
W
W
D000935:Antifungal Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000187:drug effects*; D002175:Candida / Q000187:drug effects*; D005670:Fusarium / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D009297:Nasal Mucosa / Q000737:chemistry* / Q000378:metabolism / Q000382:microbiology; D010407:Penicillium / Q000187:drug effects; D000644:Quaternary Ammonium Compounds / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000935:Antifungal Agents; D000644:Quaternary Ammonium Compounds; D013654:Taurine; C043410:N-chlorotaurine