Polymorphism of human HLA-DRB1 antigens generated by genetic exchange between DR2 (DRB1*15011) and DR6 (DRB1*1405) alleles: a novel DRB1 allele (DRB1*1437) identified in a Paiwan tribe member of Taiwan.
We report herein the identification of a new DRB1 allele using sequence-based typing (SBT). This novel allele, HLA-DRB1*1437, was found in an aboriginal individual from the Paiwan tribe in the southern part of Taiwan. This individual was typed by SBT method as having an HLA genotype of HLA-A*02011/0203, HLA-B*15011/3901, HLA-DRB1*11011/1437, HLA-DRB3*0202/0202, and HLA-DPB1*0501/1301. This new allele differs from DRB1*1309 in the 5'-end nucleotide sequence of polymorphic exon 2 at codon 16 (CAT-->CAA; H16Q), codon 37 (AAC-->TTC; R37F), codon 47 (TTC-->TAC; F47Y), and codon 58 (GCC-->GCT; both specify alanine). By sequence comparison, it was found that this new allele has a 5'-end sequence (from amino acid residues 7 to 66) identical to that found in the DRB1*1405 allele and a 3'-end sequence (from amino acid residues 58 to 94) identical to that found in the DRB1*15011 allele. Both DRB1*1405 and DRB1*15011 alleles have been identified among the Paiwan members (Note).
Wu
S
S
Tzu Chi University, Hualien, Taiwan, Republic of China. shaokee@mail.tcu.edu.tw
Shiao
Y M
YM
Lai
C Y
CY
Lai
S M
SM
Chen
S P
SP
Sidebottom
D A
DA
Hildebrand
W H
WH
Tilanus
M G
MG
Chou
F C
FC
Tsai
M F
MF
D000483:Alleles; D001483:Base Sequence; D005091:Exons / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics*; D015802:HLA-DR2 Antigen / Q000235:genetics*; D015808:HLA-DR6 Antigen / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic / Q000276:immunology*; D044469:Racial Groups; D012689:Sequence Homology, Nucleic Acid; D013624:Taiwan
D006684:HLA-DR Antigens; D015802:HLA-DR2 Antigen; D015808:HLA-DR6 Antigen; D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen; C553516:HLA-DRB1*14:37 antigen