(S)-(-)-Bromofosfamide (CBM-11): synthesis and antitumor activity and toxicity in mice.
(S)-(-)-Bromofosfamide (CBM-11), an enantiomerically pure bromo analog of ifosfamide, was found to be potent against several model tumors in mice. Therapeutic indices of CBM-11 were more favorable as compared to those received for ifosfamide.
Misiura
K
K
Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lódz, Poland. kmisiura@bio.cbmm.lodz.pl
Kinas
R W
RW
Kuśnierczyk
H
H
Radzikowski
C
C
Stec
W J
WJ
D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000627:therapeutic use*; D001682:Biological Availability; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D002851:Chromatography, High Pressure Liquid; D003433:Crosses, Genetic; D005260:Female; D007069:Ifosfamide / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D007939:Leukemia L1210 / Q000188:drug therapy*; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D015394:Molecular Structure
D018906:Antineoplastic Agents, Alkylating; C073801:bromofosfamide; D007069:Ifosfamide