Effects of olopatadine hydrochloride on the increase of histamine and peptide-leukotrienes concentrations in nasal lavage fluid following the antigen-antibody reaction in actively sensitized guinea pigs.
To investigate the mechanism for the amelioration by olopatadine hydrochloride (olopatadine) of allergic rhinitis, we determined its effects on the increase of chemical mediator concentrations in nasal lavage fluid following the intranasal antigen challenge in guinea pigs actively sensitized with DNP-Ascaris. The concentrations of histamine and peptide-leukotrienes increased 10 min after the challenge. Olopatadine at 10 mg/kg (p.o.) significantly prevented the increase of histamine and tended to inhibit the increase of peptide-leukotrienes. The inhibition by olopatadine of the nasal symptoms seems to involve the inhibitory effect on the releases of histamine and, possibly, p-LTs into the nasal cavity.
Miyake
K
K
Drug Development Research Laboratories, Pharmaceutical Research Institute, Kyowa Hakko Kogyo Co., Ltd., Sizuoka, Japan.
Horikoshi
K
K
Ikeda
Y
Y
Ishii
A
A
Karasawa
A
A
D000818:Animals; D000909:Antibodies, Helminth / Q000378:metabolism*; D000937:Antigen-Antibody Reactions / Q000187:drug effects* / Q000276:immunology; D000947:Antigens, Helminth / Q000008:administration & dosage* / Q000276:immunology* / Q000378:metabolism; D003990:Dibenzoxepins / Q000494:pharmacology*; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007110:Immunity, Active; D007274:Injections, Intraperitoneal; D015289:Leukotrienes / Q000378:metabolism*; D008297:Male; D017817:Nasal Lavage Fluid / Q000276:immunology*; D009299:Nasal Provocation Tests / Q000379:methods; D000069605:Olopatadine Hydrochloride; D013929:Thromboxane B2 / Q000378:metabolism
D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D003990:Dibenzoxepins; D006634:Histamine H1 Antagonists; D015289:Leukotrienes; D000069605:Olopatadine Hydrochloride; D013929:Thromboxane B2