The Role of the Sinusoidal Endothelium in Liver Function.
Microvascular exchange in the liver is governed by fenestrations in sinusoidal endothelial cells and can be manipulated pharmacologically. Microvascular exchange is affected in alcoholic liver disease and cirrhosis, the former leading to a loss of fenestrae, the latter to sinusoidal capillarization and thereby to loss of liver function in disease.
Reichen
Jürg
J
Department of Clinical Pharmacology of the University of Berne, Murtenstrasse 35, 3010 Berne, Switzerland.