Malignant lymphoma of the bone associated with systemic sarcoidosis.
A 57-year-old woman was hospitalized with malignant lymphoma of the right talus. After treatment, complete remission was obtained. Gallium-67 scintigraphy to confirm the remission demonstrated increased uptake in the whole body skeletal muscle, especially in her thighs. Biopsy of right gastrocnemius muscle showed epithelioid granuloma. Serum angiotensin-converting enzyme activity (ACE) and lysozyme had increased to several times the normal range. We diagnosed her disease as bone-associated sarcoidosis-lymphoma syndrome. Human herpes virus 8 (HHV-8) genome was examined in the bone marrow specimen, and the relationship between sarcoidosis-lymphoma syndrome and HHV-8 was discussed.
Kobayashi
H
H
Second Department of Internal Medicine, Aichi Medical University.
Kato
Y
Y
Hakamada
M
M
Hattori
Y
Y
Sato
A
A
Shimizu
N
N
Imamura
A
A
Mihara
H
H
Kato
H
H
Oki
Y
Y
Morishita
M
M
Miwa
H
H
Nitta
M
M
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000821:virology; D001859:Bone Neoplasms / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D005260:Female; D005710:Gallium Radioisotopes; D019288:Herpesvirus 8, Human / Q000302:isolation & purification; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography; D011877:Radionuclide Imaging; D012507:Sarcoidosis / Q000150:complications*; D013577:Syndrome; D013628:Talus / Q000000981:diagnostic imaging; D014750:Vincristine / Q000627:therapeutic use
D005710:Gallium Radioisotopes; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone