Bilateral abducens nerve paresis associated with anti-GQ1b IgG antibody.
OBJECTIVE
To describe two cases with bilateral abducens nerve paresis associated with serum anti-GQ1b IgG antibody.


METHODS
Case reports.


RESULTS
Two boys, aged 12 and 10 years, experienced acute onset of diplopia after preceding symptoms and signs of infection. In both boys, examination showed only bilateral abducens nerve paresis. Although routine laboratory data and magnetic resonance imaging demonstrated no pathologic findings, titer of anti-GQ1b IgG antibody in the sera of both patients was increased. Diplopia and signs of bilateral abducens nerve paresis disappeared in 6 weeks without any specific treatment.


CONCLUSIONS
The anti-GQ1b IgG antibody in the sera of both patients probably contributed to the bilateral abducens nerve paresis.
Sato
K
K
Department of Neurology, Kanazawa University School of Medicine, Kanazawa, Ishikawa, Japan. sato-k@pop.m.kanazawa-u.ac.jp
Yoshikawa
H
H
D020434:Abducens Nerve Diseases / Q000276:immunology* / Q000382:microbiology / Q000503:physiopathology; D000906:Antibodies / Q000032:analysis*; D002648:Child; D004172:Diplopia / Q000382:microbiology / Q000503:physiopathology; D005133:Eye Movements; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D007239:Infections / Q000150:complications / Q000503:physiopathology; D008297:Male; D012075:Remission, Spontaneous
D000906:Antibodies; D005732:Gangliosides; D007074:Immunoglobulin G; C039129:GQ1b ganglioside