title: A novel method for the prediction of functional biological activity of polyethylene wear debris.
abstract: The comparative performance of artificial hip joints has been extensively investigated in vitro through measurements of wear volumes. In vivo a major cause of long-term failure is wear-debris-induced osteolysis. These adverse biological reactions are not simply dependent on wear volume, but are also controlled by the size and volumetric concentration of the debris. A novel model is presented which predicts functional biological activity; this is determined by integrating the product of the biological activity function and the volumetric concentration function with the wear volume over the whole particle size range. This model combines conventional wear volume measurements with particle analysis and the output from in vitro cell culture studies to provide a new indicator of osteolytic potential. The application of the model is demonstrated through comparison of the functional biological activity of wear debris from polyethylene acetabular cups articulating under three different conditions in a hip joint simulator.
authors.affiliation: School of Mechanical Engineering, University of Leeds, Leeds LS2 9JT, UK.
authors.forename: J
authors.initials: J
authors.lastname: Fisher
authors.forename: J
authors.initials: J
authors.lastname: Bell
authors.forename: P S
authors.initials: PS
authors.lastname: Barbour
authors.forename: J L
authors.initials: JL
authors.lastname: Tipper
authors.forename: J B
authors.initials: JB
authors.lastname: Matthews
authors.forename: A A
authors.initials: AA
authors.lastname: Besong
authors.forename: M H
authors.initials: MH
authors.lastname: Stone
authors.forename: E
authors.initials: E
authors.lastname: Ingham
mesh_terms: D001672:Biocompatible Materials; D001843:Bone Cements / Q000009:adverse effects; D005547:Foreign Bodies / Q000175:diagnosis / Q000209:etiology / Q000276:immunology; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008264:Macrophages / Q000276:immunology; D008422:Materials Testing; D010014:Osteolysis / Q000209:etiology* / Q000503:physiopathology; D010316:Particle Size; D020959:Polyethylene / Q000032:analysis*; D011474:Prosthesis Design; D011475:Prosthesis Failure; D006113:United Kingdom
chemical_list: D001672:Biocompatible Materials; D001843:Bone Cements; D020959:Polyethylene