title: [Rational therapy of Alzheimer dementia based on current clinical studies].
abstract: Several preparations are currently available for the treatment of Alzheimer's dementia. To date only some of these drugs could show evidence of efficacy that would justify a recommendation for their therapeutic use. In the present survey, the results of five controlled clinical trials with acetylcholinesterase inhibitors versus Ginkgo-biloba extract have been analysed. The trials conducted with the acetylcholinesterase altogether have a larger patient population, an acceptable significance level of therapeutic effect as well as a lower rate of drop outs. Based on the documentation presented here, only the approved acetylcholinesterase inhibitors are currently to be recommended under strict scientific criteria for use in the treatment of Alzheimer's dementia.
authors.affiliation: Abteilung für psychiatrische Forschung, Psychiatrische Universitätsklinik, Zürich.
authors.forename: B
authors.initials: B
authors.lastname: Zöller
authors.forename: C
authors.initials: C
authors.lastname: Hock
authors.forename: H U
authors.initials: HU
authors.lastname: Kull
mesh_terms: D000203:Activities of Daily Living / Q000145:classification; D000368:Aged; D000544:Alzheimer Disease / Q000188:drug therapy*; D002800:Cholinesterase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005419:Flavonoids / Q000009:adverse effects / Q000627:therapeutic use*; D020441:Ginkgo biloba; D006801:Humans; D008297:Male; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D009483:Neuropsychological Tests; D010936:Plant Extracts; D016032:Randomized Controlled Trials as Topic; D016896:Treatment Outcome; D000096983:Ginkgo Extract
chemical_list: D002800:Cholinesterase Inhibitors; D005419:Flavonoids; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract