New ligands bearing chiral bioactive fragments.
[see reaction]. Reliable and practical synthetic routes for the construction of hybrid molecules bearing both a chelating center and a useful biofunction are presented. They comprise the sequential cross-coupling reaction between ethynylated synthons with iodo-substituted L-tyrosine derivatives and provide access to various rationally designed chiral ligands.
Khatyr
A
A
Laboratoire de Chimie, d'Electronique et de Photonique Moléculaires, Associé au CNRS ESA-7008, Ecole de Chimie, Polymères, Matériaux de Strasbourg, 25 rue Becquerel, 67087 Strasbourg Cedex 02, France.
Ziessel
R
R
D008024:Ligands; D010165:Palladium / Q000737:chemistry; D045322:Photosynthetic Reaction Center Complex Proteins / Q000737:chemistry*; D013237:Stereoisomerism; D014443:Tyrosine / Q000737:chemistry*
D008024:Ligands; D045322:Photosynthetic Reaction Center Complex Proteins; D014443:Tyrosine; D010165:Palladium