title: Syntheses of two deacetyl-thymosin beta4 analogs and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw.
abstract: Two [Met(0)6]deacetyl-thymosin beta4 analogs containing Phe(4F) or Tyr(Me) at position 12 were synthesized by the manual solid-phase method, and their anti-inflammatory effect on carrageenin-induced edema in the mouse paw was studied. Fluorination of the para-position of Phe12 resulted in a marked antiinflammatory effect on carrageenin-induced edema in the mouse paw compared with that of our synthetic [Met(0)6]deacetyl-thymosin beta4, but the other analog, [Met(0)6, Tyr(Me)12]deacetyl-thymosin beta4, showed a marked reduction of the anti-inflammatory effect.
authors.affiliation: Research Laboratory, Global Shinwa Pharmaceutical Co. Ltd., Iwate-ken, Japan. lab@mx2.alpha-web.ne.jp
authors.forename: T
authors.initials: T
authors.lastname: Abiko
authors.forename: R
authors.initials: R
authors.lastname: Ogawa
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy*; D006614:Hindlimb; D051379:Mice; D008807:Mice, Inbred BALB C; D013947:Thymosin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000627:therapeutic use*
chemical_list: C438224:(Met(0)6,Phe(4F)12)deacetyl-thymosin beta4; C438225:(Met(0)6,Tyr(Me)12)deacetyl-thymosin beta4; D000894:Anti-Inflammatory Agents, Non-Steroidal; D013947:Thymosin