Effects of opiate receptor ligands on DNA synthesis in tracheal epitheliocytes and smooth muscle cells of newborn albino rats.
The dermorphin analogue A10 injected to newborn rats from the 2nd to 6th day of life increased the index of labeled nuclei in epitheliocytes and smooth muscle cells and labeling intensity in smooth muscle cells. Dynorphin A(1-13)increased the index of labeled nuclei and labeling intensity in epitheliocytes and labeling intensity in smooth muscle cells. Dalargin increased the labeling intensity in epitheliocytes, but had effect on DNA synthesis in muscle cells.
Lebed'ko
O A
OA
Institute of Maternity and Child Welfare, Khabarovsk Branch, Far-Eastern State Medical University, Khabarovsk, Russia.
Timoshin
S S
SS
D000700:Analgesics / Q000494:pharmacology; D000701:Analgesics, Opioid / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D000975:Antioxidants / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004847:Epithelial Cells / Q000187:drug effects* / Q000378:metabolism; D008024:Ligands; D050356:Lipid Metabolism; D008168:Lung / Q000378:metabolism; D009130:Muscle, Smooth / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009842:Oligopeptides / Q000737:chemistry / Q000494:pharmacology*; D018847:Opioid Peptides; D051381:Rats; D011957:Receptors, Opioid / Q000819:agonists* / Q000378:metabolism; D014132:Trachea / Q000166:cytology* / Q000187:drug effects
D000700:Analgesics; D000701:Analgesics, Opioid; D000975:Antioxidants; D008024:Ligands; D009842:Oligopeptides; D018847:Opioid Peptides; D011957:Receptors, Opioid; C030058:dermorphin; D016308:Enkephalin, Leucine-2-Alanine; D004247:DNA; C040996:enkephalin-Leu, Ala(2)-Arg(6)-