title: Surgical treatment of prosthetic valve endocarditis with left ventricular-aortic discontinuity: reconstruction of the left ventricular outflow tract with a xenopericardial conduit.
abstract: OBJECTIVE
  Aortic prosthetic valve endocarditis (PVE) with annular destruction presents a challenge that requires techniques to eradicate the infection and correct the hemodynamic abnormality.
  
  
  METHODS
  Between July 1, 1996 and March 31, 2000, six patients with native or PVE of the aortic valve and aortic annular destruction underwent surgical treatment. Of these patients, three (two men, one woman; mean age 71.0 years) had circumferential annular destruction of the aortic annulus, and formed the basis of this study. The microorganisms responsible for the infection were Streptococcus spp. in two patients and Staphylococcus aureus in one patient. In addition to aggressive debridement of the infected tissue, repair was achieved by reconstruction of the left ventricular outflow tract with a xenopericardial conduit and fixation of the new prosthetic valve to the conduit.
  
  
  RESULTS
  One patient with ventricular septal perforation, multiple systemic embolism and sepsis died of low cardiac output syndrome soon after surgery. Two operative survivors were followed up for 9 and 51 months, with no late deaths. No patient has experienced recurrent infection, pericardial patch aneurysm, or prosthetic valve detachment.
  
  
  CONCLUSIONS
  These operative procedures provide easy and secure fixation of the pericardial patch to the healthy tissue under excellent operative view, as well as a sturdy structure for the fixation of the new prosthesis, and complete exclusion of the abscess cavity from the blood stream.
authors.affiliation: Department of Surgery, Kurume University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Aoyagi
authors.forename: S
authors.initials: S
authors.lastname: Fukunaga
authors.forename: E
authors.initials: E
authors.lastname: Tayama
authors.forename: N
authors.initials: N
authors.lastname: Hayashida
authors.forename: T
authors.initials: T
authors.lastname: Kawara
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical; D001018:Aortic Diseases / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D001021:Aortic Valve / Q000503:physiopathology / Q000601:surgery*; D004696:Endocarditis / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008297:Male; D010496:Pericardium / Q000637:transplantation*; D016459:Prosthesis-Related Infections / Q000503:physiopathology / Q000601:surgery*; D014183:Transplantation, Heterologous; D018487:Ventricular Dysfunction, Left / Q000209:etiology* / Q000503:physiopathology / Q000601:surgery*