Uroguanylin level in umbilical cord blood.
BACKGROUND
Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine.


METHODS
To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality.


RESULTS
Mean (+/- SD) cord plasma uroguanylin concentrations (8.8 +/- 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality.


CONCLUSIONS
These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.
Tsukahara
H
H
Department of Pediatrics, Fukui Medical University, Fukui, Japan. htsuka@fmsrsa.fukui-u.ac.jp
Sekine
K
K
Uchiyama
M
M
Miura
M
M
Nakazato
M
M
Date
Y
Y
Tsunezawa
W
W
Kotsuji
F
F
Nishida
K
K
Hiraoka
M
M
Mayumi
M
M
D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D045265:Natriuretic Peptides; D009994:Osmolar Concentration; D010455:Peptides / Q000097:blood*
D045265:Natriuretic Peptides; D010455:Peptides; C084362:uroguanylin