Wilson's disease in pregnancy: five successful consecutive pregnancies of the same woman.
Wilson's disease is an autosomal recessive disorder of copper metabolism characterized mainly by liver cirrhosis and neurological disorders. Appropriate treatment with chelating agents allows normal fertility function. We report five consecutive successful pregnancies of the same woman, treated in the high-risk unit at our medical center. The management dilemmas and treatment options are discussed.
Furman
B
B
Department of Obstetrics and Gynecology, Faculty of Health Sciences, Soroka Medical Center, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Bashiri
A
A
Wiznitzer
A
A
Erez
O
O
Holcberg
G
G
Mazor
M
M
D000410:Alanine Transaminase / Q000097:blood; D001034:Apgar Score; D001219:Aspartate Aminotransferases / Q000097:blood; D002614:Chelating Agents / Q000627:therapeutic use; D005260:Female; D005865:Gestational Age; D006527:Hepatolenticular Degeneration / Q000188:drug therapy*; D006801:Humans; D007231:Infant, Newborn; D010396:Penicillamine / Q000627:therapeutic use; D010976:Platelet Count; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome; D012307:Risk Factors
D002614:Chelating Agents; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D010396:Penicillamine