An efficient synthesis of mimetics of neamine for RNA recognition.
As mimetics of neamine, several 4-heterocyclic 2-deoxystreptamine derivatives were chemically synthesized for RNA recognition. Conversion of 4-methylthiomethyl-5,6-di-O-acetyl-diazido-2-deoxystreptamine to the 4-chloromethyl derivative followed by reactions with different nuclophilic reagents gave the 4-heterocyclic 2-deoxystreptamine derivatives in satisfactory yields.
Ding
Y
Y
Ibis Therapeutics, a Division of Isis Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008, USA. yding@isisph.com
Hofstadler
S A
SA
Swayze
E E
EE
Griffey
R H
RH
D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D018716:Molecular Mimicry; D009355:Neomycin / Q000138:chemical synthesis*; D012313:RNA / Q000187:drug effects*; D012997:Solvents
D006571:Heterocyclic Compounds; D007202:Indicators and Reagents; D012997:Solvents; D012313:RNA; D009355:Neomycin