Permanent cerebellar toxicity of cytosine arabinoside (Ara C) in a young woman.
This report provides the first videotape example of a patient with permanent cerebellar ataxia from high dose cytosine arabinoside. This case was unusual in that the patient was young, the effects are seemingly permanent and severe, and corticospinal tract damage also occurred. Early recognition to stop drug administration remains the only method to reduce risk.
Friedman
J H
JH
Department of Clinical Neurosciences, Division of Neurology, Brown University Medical School, Memorial Hospital of Rhode Island, 111 Brewster Street, Pawtucket, RI 02860, USA.
Shetty
N
N
D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects*; D001284:Atrophy; D002524:Cerebellar Ataxia / Q000139:chemically induced* / Q000473:pathology; D002531:Cerebellum / Q000473:pathology*; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D014743:Videotape Recording
D000964:Antimetabolites, Antineoplastic; D003561:Cytarabine