Causes of the clinical tissue response to polyglycolide and polylactide implants with an emphasis on the knee.
The causes of a clinical tissue response to self-reinforced polyglycolide (SR-PGA) and self-reinforced polylactide (SR-PLLA) implants were studied in the first 2500 polymeric fixations. The incidence was 8.0% in fixations with implants made of SR-PGA (n = 1879) and 0% in SR-PLLA fixations (n = 621). A small number of fixations per site seemed to increase the incidence of a tissue response. In diagnoses involving over 50 fixations, except for ankle fractures, the incidence was 4.2%. The site of fixation influenced the incidence; the lowest incidence was seen for radial head fracture fixation (1.1%). The aromatic dye which has not been used since 1988 in the SR-PGA implant increased the response. A large total implant volume and a large number of implants increased the incidence of a tissue response. In the knee (n = 131), the incidence of a clinical tissue response was 4.3%, with four fluid accumulations and one synovitis of the knee after fixation with SR-PGA implants.
Tuompo
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Helsinki University Central Hospital, Töölö Hospital, Department of Orthopaedics and Traumatology, Finland. pertti.tuompo@pp.inet.fi
Paritio
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Pätiälä
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Jukkala-Partio
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Hirvensalo
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Rokkanen
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D020341:Absorbable Implants; D000070598:Anterior Cruciate Ligament Injuries; D005264:Femoral Fractures / Q000601:surgery; D006801:Humans; D007718:Knee Injuries / Q000601:surgery*; D007719:Knee Joint; D019637:Orthopedic Procedures; D011091:Polyesters; D011100:Polyglycolic Acid; D012421:Rupture
D011091:Polyesters; D011100:Polyglycolic Acid; C033616:poly(lactide)