title: Gravity effects on regional lung ventilation determined by functional EIT during parabolic flights.
abstract: Gravity-dependent changes of regional lung function were studied during normogravity, hypergravity, and microgravity induced by parabolic flights. Seven healthy subjects were followed in the right lateral and supine postures during tidal breathing, forced vital capacity, and slow expiratory vital capacity maneuvers. Regional 1) lung ventilation, 2) lung volumes, and 3) lung emptying behavior were studied in a transverse thoracic plane by functional electrical impedance tomography (EIT). The results showed gravity-dependent changes of regional lung ventilation parameters. A significant effect of gravity on regional functional residual capacity with a rapid lung volume redistribution during the gravity transition phases was established. The most homogeneous functional residual capacity distribution was found at microgravity. During vital capacity and forced vital capacity in the right lateral posture, the decrease in lung volume on expiration was larger in the right lung region at all gravity phases. During tidal breathing, the differences in ventilation magnitudes between the right and left lung regions were not significant in either posture or gravity phase. A significant nonlinearity of lung emptying was determined at normogravity and hypergravity. The pattern of lung emptying was homogeneous during microgravity.
authors.affiliation: Department of Anesthesiological Research, Center of Anesthesiology, Emergency and Intensive Care Medicine, University of Göttingen, D-37075 Göttingen, Germany. isipink@gwdg.de
authors.forename: I
authors.initials: I
authors.lastname: Frerichs
authors.forename: T
authors.initials: T
authors.lastname: Dudykevych
authors.forename: J
authors.initials: J
authors.lastname: Hinz
authors.forename: M
authors.initials: M
authors.lastname: Bodenstein
authors.forename: G
authors.initials: G
authors.lastname: Hahn
authors.forename: G
authors.initials: G
authors.lastname: Hellige
mesh_terms: D000328:Adult; D017097:Electric Impedance; D005260:Female; D005652:Functional Residual Capacity; D006112:Gravitation; D006801:Humans; D008168:Lung / Q000502:physiology*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D017711:Nonlinear Dynamics; D011187:Posture; D012119:Respiration; D012143:Respiratory Physiological Phenomena; D013026:Space Flight; D013990:Tidal Volume; D014054:Tomography; D014797:Vital Capacity