title: Malignancy: Molecular Demonstration of BCR/ABL Fusion in a Patient with Chronic Myelogenous Leukemia with Basophilia Carrying a Variant t(16;22) (q24;q11) Philadelphia Chromosome.
abstract: We report a patient with chronic myelogenous leukemia in chronic phase and basophilia which was found to carry a simple variant t(16;22) (q24;q11) Philadelphia (Ph) chromosome in unstimulated bone marrow mononuclear cells. Molecular analysis of peripheral blood and bone marrow mononuclear cells demonstrated the presence of a bcr-abl chimeric mRNA transcript of the b(3) -a(2) type. These findings confirm that band 9q34 participates in the formation of all Ph chromosomes, either standard or variant, even when this is not detectable by conventional cytogenetics. The available literature concerning variant Philadelphia translocations is also reviewed.
authors.affiliation: First Department of Medicine, University of Athens, Laikon General Hospital, Athens, Greece; Diagnostic Genetic Center, Athens, Greece.
authors.forename: MARINA
authors.initials: M
authors.lastname: Mantzourani
authors.forename: NIKI
authors.initials: N
authors.lastname: Stavroyianni
authors.forename: DANAI
authors.initials: D
authors.lastname: Abazis
authors.forename: PANAYIOTIS
authors.initials: P
authors.lastname: Kyriazopoulos
authors.forename: CONSTANTINOS
authors.initials: C
authors.lastname: Pangalos
authors.forename: DIMITRIS
authors.initials: D
authors.lastname: Loukopoulos
authors.forename: XENOPHON
authors.initials: X
authors.lastname: Yataganas