Adrenaline modulates multiple conductances in rat vagal motoneurones in vitro.
Whole cell recordings were undertaken from vagal motoneurones, including identified gastric vagal motoneurones, located within the medial regions of the dorsal vagal motonucleus of the rat medulla in vitro. The actions of adrenaline on individual channels expressed by these neurones were investigated. Adrenaline directly inhibits Ca2+ currents and delayed rectifier K+ currents and activates a sustained Na+ current. It also inhibits both Ca2+ activated non-selective cationic currents and Ca2+ activated K+ currents, the latter via inhibition of the underlying activating Ca2+ current. Since different sub-populations of vagal motoneurones express different complements of ion channels, this selective modulation of specific conductances by adrenaline may provide a mechanism by which adrenergic inputs, which project non-selectively throughout the DMV, could selectively control different aspects of vagal function.
Bouryi
V A
VA
School of Biomedical Sciences, University of Leeds, UK.
Lewis
D I
DI
D000818:Animals; D004594:Electrophysiology; D004837:Epinephrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000166:cytology / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009046:Motor Neurons / Q000502:physiology*; D009431:Neural Conduction / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D014630:Vagus Nerve / Q000502:physiology*
D007473:Ion Channels; D004837:Epinephrine