title: Anticocaine catalytic antibodies have no affinity for RTI compounds: implications for treatment.
abstract: Potential medications for cocaine abusers include: anticocaine catalytic antibodies, which could serve as circulating peripheral blockers of cocaine that prevents its action in the brain; and 3-phenyltropane cocaine analogs, which could serve as potent, selective, and long-lasting substitutes that reduce drug-seeking. In order to evaluate the compatibility of these agents, we measured if a catalytic antibody would bind and interact with some cocaine analogs. Anticocaine catalytic antibody 15A10 had no significant affinity for RTI-51, RTI-112, or RTI-177 as examined by ELISA. They exhibited high affinity for the immunogen TSA1 in the same experiment, as expected. Because the antibody and the RTI compounds do not interact, they are candidates for simultaneous use.
authors.affiliation: Yerkes Regional Primate Center of Emory University, Atlanta, Georgia 30329, USA. mkuhar@rmy.emory.edu
authors.forename: M J
authors.initials: MJ
authors.lastname: Kuhar
authors.forename: F I
authors.initials: FI
authors.lastname: Carroll
authors.forename: N
authors.initials: N
authors.lastname: Bharat
authors.forename: D W
authors.initials: DW
authors.lastname: Landry
mesh_terms: D018759:Adrenergic Uptake Inhibitors / Q000494:pharmacology; D017151:Antibodies, Catalytic / Q000737:chemistry / Q000276:immunology* / Q000494:pharmacology; D000915:Antibody Affinity / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology; D002352:Carrier Proteins / Q000187:drug effects / Q000378:metabolism; D003042:Cocaine / Q000031:analogs & derivatives* / Q000276:immunology* / Q000494:pharmacology; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000276:immunology / Q000503:physiopathology; D004359:Drug Therapy, Combination; D004797:Enzyme-Linked Immunosorbent Assay; D008454:Mazindol / Q000494:pharmacology; D014326:Tropanes / Q000737:chemistry / Q000276:immunology* / Q000494:pharmacology
chemical_list: C095429:3-(4'-chlorophenyl)-2-(3'-phenylisoxazol-5'-yl)tropane; D018759:Adrenergic Uptake Inhibitors; D017151:Antibodies, Catalytic; D002352:Carrier Proteins; C432869:RTI 112; C432868:RTI 51; D014326:Tropanes; D008454:Mazindol; D003042:Cocaine