[Cyclin-dependent kinase 4 inhibitor a and tumor].
INK4a/ARF locus encodes at least two products, P16(INK4a) and P19(ARF), which are very important in controlling cell-cycle arrest and apoptosis. Many human cancers have been found to be highly related to the mutations at this locus. Here is a review of its structure, function and role in tumor suppression.
Gong
Z
Z
Medical Genetics Department, the Second Military Medical University, Shanghai 200433 P. R. China. jlfu@guomai.sh.cn
Fu
J
J
D000818:Animals; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000737:chemistry / Q000502:physiology*; D019942:Genes, p16; D016158:Genes, p53; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D025803:Tumor Suppressor Protein p14ARF
D019941:Cyclin-Dependent Kinase Inhibitor p16; D011506:Proteins; D025803:Tumor Suppressor Protein p14ARF