title: Somatostatins and their receptors in fish.
abstract: Somatostatin (SRIF) is a multigene family of peptides. SRIF-14 is conserved with identical primary structure in species across the vertebrates. The presence of multiple SRIF genes has been demonstrated in a number of fish species. Notably, three distinct SRIF genes have been identified in goldfish. One of these genes, which encodes [Pro(2)]SRIF-14, has also been identified in sturgeon and African lungfish, and is closely associated with the amphibian [Pro(2),Met(13)]SRIF-14 gene and mammalian cortistatin gene. The main neuroendocrine role of SRIF-14 peptide that has been determined in fish is the inhibition of pituitary growth hormone secretion. The functions of SRIF-14 variant or larger forms of SRIF peptide and the regulation of SRIF gene expression remain to be explored. Type one and two SRIF receptors have been identified from goldfish and type three SRIF receptor from an electric fish. Fish SRIF receptors display considerable homology to mammalian counterparts in terms of primary structure and negative coupling to adenylate cyclase. The identification of the multiple gene family of SRIF peptides and multiple types of SRIF receptors in fish opens a new avenue for the study of physiological roles of SRIF, and the molecular and cellular mechanisms of SRIF actions in fish.
authors.affiliation: Department of Biological Sciences, University of Alberta, Alberta T6G 2E9, Edmonton, Canada.
authors.forename: X
authors.initials: X
authors.lastname: Lin
authors.forename: R E
authors.initials: RE
authors.lastname: Peter
mesh_terms: D000818:Animals; D005399:Fishes / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D005810:Multigene Family; D017481:Receptors, Somatostatin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D013004:Somatostatin / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
chemical_list: D017481:Receptors, Somatostatin; D013004:Somatostatin