Progress toward the total synthesis of kalihinane diterpenoids.
[see structure]. Studies toward the total synthesis of marine diterpenoids isolated from Acanthella sp., e.g., kalihinol A, are described. Efficient construction of the functionalized trans-decalin core (11) is achieved through intramolecular Diels-Alder cyclization followed by diastereoselective epoxidation and aziridination.
White
R D
RD
Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
Wood
J L
JL
D000818:Animals; D004224:Diterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D011161:Porifera / Q000737:chemistry
D004224:Diterpenes; C431469:kalihinane