title: Lack of positive interaction between CO2 and hypoxic stimulation for P(CO2)-VAS response slope in humans.
abstract: To compare the effect of hypoxia on ventilatory responses and respiratory sensation to carbon dioxide, 29 young adults were examined using a modified Read's rebreathing method with four experimental conditions. We used varying gas mixtures and kept PET(O2) constant at >300, 100, 80 and 60 mmHg for each four rebreathing tests. Respiratory sensation was measured by visual analog scale (VAS). The slope of the CO2-ventilation response curve increased significantly with hypoxia, confirming a positive ventilatory interaction between hypoxia and hypercapnia. However, the slope of the CO2-VAS response curve remained unchanged. The V(E)-VAS relation slope tended to become depressed with advancing hypoxia, i.e. the magnitude of VAS elicited by a given ventilation decreased with hypoxia, signifying that dyspneic sensation was effectively mitigated during hypoxic hyperventilation. We suggest that this relief of dyspneic sensation might be due to the inhibitory respiratory effect from augmented pulmonary stretch receptor (PSR) activity.
authors.affiliation: Department of Nursing Science, School of Allied Health Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, 113-8519, Tokyo, Japan. a.masuda.ns@tmd.ac.jp
authors.forename: A
authors.initials: A
authors.lastname: Masuda
authors.forename: Y
authors.initials: Y
authors.lastname: Ohyabu
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: C
authors.initials: C
authors.lastname: Yoshino
authors.forename: Y
authors.initials: Y
authors.lastname: Sakakibara
authors.forename: T
authors.initials: T
authors.lastname: Komatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Honda
mesh_terms: D000328:Adult; D002245:Carbon Dioxide; D004417:Dyspnea / Q000503:physiopathology; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D010147:Pain Measurement; D010313:Partial Pressure; D012119:Respiration; D012677:Sensation
chemical_list: D002245:Carbon Dioxide