title: Autoantibodies to beta-amyloid and neurotransmitters in patients with Alzheimer's disease and senile dementia of the Alzheimer type.
abstract: The content of autoantibodies to beta-amyloid protein Abeta(1-42), its neurotoxic fragment Abeta(25-35), and neurotransmitters were studied in the blood of patients with presenile Alzheimer's disease and senile dementia of the Alzheimer type. Significant differences in the relative content of autoantibodies to Abeta(1-42)and autoantibodies to biogenic amines were demonstrated. These results can be used for the development of a biochemical method for differential diagnosis of Alzheimer dementias.
authors.affiliation: Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
authors.forename: M A
authors.initials: MA
authors.lastname: Myagkova
authors.forename: S I
authors.initials: SI
authors.lastname: Gavrilova
authors.forename: N N
authors.initials: NN
authors.lastname: Lermontova
authors.forename: Y B
authors.initials: YB
authors.lastname: Kalyn
authors.forename: N D
authors.initials: ND
authors.lastname: Selezneva
authors.forename: G A
authors.initials: GA
authors.lastname: Zharikov
authors.forename: I V
authors.initials: IV
authors.lastname: Kolykhalov
authors.forename: T V
authors.initials: TV
authors.lastname: Abramenko
authors.forename: T P
authors.initials: TP
authors.lastname: Serkova
authors.forename: S O
authors.initials: SO
authors.lastname: Bachurin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D016229:Amyloid beta-Peptides / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D000704:Analysis of Variance; D001323:Autoantibodies / Q000097:blood*; D015306:Biogenic Monoamines / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood / Q000276:immunology* / Q000378:metabolism
chemical_list: D016229:Amyloid beta-Peptides; D001323:Autoantibodies; D015306:Biogenic Monoamines; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C074636:amyloid beta-protein (25-35)