title: Clustering and analysis of protein families.
abstract: Various sequence-motif and sequence-cluster databases have been integrated into a new resource known as InterPro. Because the contributing databases have different clustering principles and scoring sensitivities, the combined assignments complement each other for grouping protein families and delineating domains. InterPro and new developments in the analysis of both the phylogenetic profiles of protein families and domain fusion events improve the prediction of specific functions for numerous proteins.
authors.affiliation: EMBL Outstation, The European Bioinformatics Institute, Wellcome Trust Genome Campus, Cambridgeshire CB10 1SD, Hinxton, UK.
authors.forename: E V
authors.initials: EV
authors.lastname: Kriventseva
authors.forename: M
authors.initials: M
authors.lastname: Biswas
authors.forename: R
authors.initials: R
authors.lastname: Apweiler
mesh_terms: D020816:Amino Acid Motifs; D016208:Databases, Factual; D010802:Phylogeny; D011506:Proteins; D016415:Sequence Alignment / Q000379:methods
chemical_list: D011506:Proteins