title: Preparation of 1,4-oxaselenin from agNO(3)/LDA-assisted reaction of 3-selena-4-pentyn-1-one as potential antitumor agents.
abstract: 1,4-Oxaselenins were synthesized from 3-selena-4-pentyn-1-ones by the use of AgNO(3) and LDA. One of the obtained oxaselenins, 2-(4-chlorophenyl)-6-phenyl-1,4-oxaselenin 5c, showed an inhibitory effect against the proliferation of human cancer cells and inducing effects on the early stage of apoptosis.
authors.affiliation: Department of Chemistry, Faculty of Engineering, Gifu University, Gifu, 501-1193 Japan. koketsu@cc.gifu-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Koketsu
authors.forename: H O
authors.initials: HO
authors.lastname: Yang
authors.forename: Y M
authors.initials: YM
authors.lastname: Kim
authors.forename: M
authors.initials: M
authors.lastname: Ichihashi
authors.forename: H
authors.initials: H
authors.lastname: Ishihara
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D018036:Selenium Compounds / Q000737:chemistry*; D012835:Silver Nitrate
chemical_list: C431045:1,4-oxaselenin; C431044:3-selena-4-pentyn-1-one; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D018036:Selenium Compounds; D012835:Silver Nitrate