title: An old epithelial cell never dies, it just agonesces away.
abstract: The behavior of mammary epithelial cells during aging is dynamic and is likely to have significant implications in the pathogenesis of human breast cancer. The growth of epithelial cells over time was thought to parallel that of their underlying stroma, sequentially undergoing a defined period of growth, followed by senescence and, ultimately, cell crisis or rarely immortalization. Recent findings, however, suggest that the evolution of mammary epithelium at the proliferative and chromosomal levels is distinct from that of stroma, contributing to the neoplastic susceptibilities of epithelial cells.
authors.forename: C V
authors.initials: CV
authors.lastname: Clevenger
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology; D016923:Cell Death; D016922:Cellular Senescence; D004847:Epithelial Cells / Q000166:cytology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008954:Models, Biological