Stimulatory and Inhibitory Functions of the R Domain on CFTR Chloride Channel.
CFTR is a chloride channel whose gating process involves coordinated interactions among the regulatory (R) domain and the nucleotide-binding folds (NBFs). Protein kinase A phosphorylation of serine residues renders the R domain from inhibitory to stimulatory and enables ATP binding and hydrolysis at the NBFs, which in turn control opening and closing of the chloride channel.
Ma
Jianjie
J
Department of Physiology and Biophysics at Case Western Reserve University School of Medicine, 10900 Euclid Avenue, Cleveland, OH 44106.