[The role of angiotensin I converting enzyme (ACE) Pst 1 polymorphism in the development of chronic renal failure].
Chronic renal failure (CRF) is a complex phenotype, which results from the underlying kidney disease and superimposing environmental and genetic factors. The aim of the study was to evaluate the role of angiotensin converting enzyme gene Pst 1 polymorphism in the development and/or progression of CRF. 247 family trios (patients with CRF and both parents): 120 with primary chronic glomerulonephritis, 80 with interstitial nephritis and 47 with diabetic nephropathy were examined, and transmission/disequilibrium test (TDT) was used to evaluate allele transmission from heterozygous parents to affected off-spring. No significant deviation from random transmission of the examined ACE gene Pst 1 alleles was observed, as well as no impact of this marker on the rate of progression of chronic renal failure.
Gumprecht
J
J
Katedra i Klinika Chorób Wewnetrznych i Diabetologii Sl. AM w Katowicach.
Zychma
M J
MJ
Grzeszczak
W
W
Zukowska-Szczechowska
E
E
D000328:Adult; D002908:Chronic Disease; D003928:Diabetic Nephropathies / Q000201:enzymology / Q000235:genetics; D018450:Disease Progression; D005260:Female; D005819:Genetic Markers; D005921:Glomerulonephritis / Q000201:enzymology / Q000235:genetics; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology* / Q000235:genetics*; D008297:Male; D009395:Nephritis, Interstitial / Q000201:enzymology / Q000235:genetics; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D012799:Sialyltransferases / Q000235:genetics*
D005819:Genetic Markers; D012799:Sialyltransferases; D007703:Peptidyl-Dipeptidase A