[Role of oncogenic G-proteins in development of endocrine neoplasms].
New data available in the literature on the role of oncogenic heterotrimeric GTP-proteins (G-proteins) in endocrine tissue carcinogenesis have been analyzed. A conclusion is made that stimulatory G-proteins coded by the gsp-oncogene are a major factor of the development of some pituitary and thyroid tumors. However, the role of the other oncogenic G-proteins in tumorigenesis remains unclear.
Shpakov
A O
AO
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg.
D002471:Cell Transformation, Neoplastic; D020962:Heterotrimeric GTP-Binding Proteins / Q000235:genetics / Q000502:physiology*; D006801:Humans; D009154:Mutation; D015513:Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D013964:Thyroid Neoplasms / Q000503:physiopathology*
D015513:Oncogene Proteins; D020962:Heterotrimeric GTP-Binding Proteins