Successful lung transplantation for bronchiolitis obliterans after allogeneic marrow transplantation.
BACKGROUND
Bone marrow transplantation (BMT) is an established therapy for a variety of hematological diseases with curative potential. However, despite improvements in supportive care, pulmonary complications remain a significant cause of morbidity and mortality.


METHODS
We report on a patient who received a double lung transplantation (LTX) for therapy-refractory bronchiolitis obliterans (BO) associated with extensive chronic graft-versus-host disease (GVHD) after allogeneic BMT.


RESULTS
At present, 38 months after BMT and 23 months after LTX, the patient is in complete hematological and cytogenetic remission and without signs of respiratory distress.


CONCLUSIONS
This case illustrates that lung transplantation could be a therapeutic option in selected patients with BO after allogeneic BMT that is associated with extensive chronic GVHD and who are refractory to conventional immunosuppressive therapy.
Rabitsch
W
W
Department of Radiology, University of Vienna, Austria.
Deviatko
E
E
Keil
F
F
Herold
C
C
Dekan
G
G
Greinix
H T
HT
Lechner
K
K
Klepetko
W
W
Kalhs
P
P
D000328:Adult; D016026:Bone Marrow Transplantation; D001989:Bronchiolitis Obliterans / Q000601:surgery*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D016040:Lung Transplantation; D008297:Male; D014184:Transplantation, Homologous; D016896:Treatment Outcome