Activities of apoptotic signal 1-regulating protein kinase and poly-(ADP-ribose) polymerase and internucleosomal DNA fragmentation in rat liver during oxidative stress induced by cobalt chloride.
We revealed activation of apoptotic signal 1-regulating protein kinase, inhibition of poly-(ADP-ribose) polymerase, and intensification of internucleosomal DNA fragmentation in rat liver during oxidative stress induced by cobalt chloride.
Sumbayev
V V
VV
Department of Biochemistry, I. M. Mechnikov Odessa National University, Odessa, Russia. inna@farlep.net
D000818:Animals; D003035:Cobalt / Q000494:pharmacology; D053938:DNA Fragmentation; D005260:Female; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D048848:MAP Kinase Kinase Kinase 5; D020930:MAP Kinase Kinase Kinases / Q000378:metabolism*; D018384:Oxidative Stress; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D003035:Cobalt; D011065:Poly(ADP-ribose) Polymerases; D048848:MAP Kinase Kinase Kinase 5; D020930:MAP Kinase Kinase Kinases; C018021:cobaltous chloride