The effect of zinc supply on cadmium-induced changes in the tibia of rats.
It has been determined that zinc supplementation (240 microg Zn/ml) during (for 12 weeks) or after (for 2 weeks) cadmium exposure (50 microg Cd/ml for 12 weeks) can prevent the accumulation and toxic action of Cd in the tibia of rats. The exposure to Cd led to disturbances in bone metabolism reflected by changes in the chemical composition of bone and decreased bone mineral density (osteomalacian changes). The Zn supply in conditions of Cd intoxication completely prevented the Cd-induced increase in percentage of water content and decrease in tibia ash weight, ash weight/dry weight, non-org. comp./org. comp., Zn content and concentration. Moreover, Zn partly protected from the decrease in Ca concentration and content, percentage of non-organic components content, Ca/wet weight, Ca/ash weight and Ca/dry weight. Zn administered after Cd exposure partly, but not completely, protected from Cd-induced decrease in percentage of non-organic components content, Ca/wet weight as well as Ca content and concentration. This protective effect on bone was most evident when Zn was administered during Cd exposure. But Zn, independently of the manner of its administration, did not prevent Cd accumulation in the tibia. Our results suggest that Zn supply in conditions of simultaneous exposure can prevent Cd-induced bone loss to some extent, and used after Cd treatment can give therapeutic benefits.
Brzóska
M M
MM
Department of Toxicology, Medical Academy, Mickiewicza 2c str., 15-222, Bialystok, Poland. mmbr@friko7.onet.pl
Moniuszko-Jakoniuk
J
J
Jurczuk
M
M
Galazyn-Sidorczuk
M
M
Rogalska
J
J
D000818:Animals; D015519:Bone Density; D002104:Cadmium / Q000008:administration & dosage / Q000032:analysis / Q000494:pharmacology*; D002118:Calcium / Q000032:analysis; D007501:Iron / Q000032:analysis; D008297:Male; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia / Q000737:chemistry / Q000187:drug effects* / Q000378:metabolism; D014867:Water / Q000032:analysis; D015032:Zinc / Q000008:administration & dosage* / Q000032:analysis
D002104:Cadmium; D014867:Water; D007501:Iron; D015032:Zinc; D002118:Calcium