title: Randomization at the level of primary care practice: use of pre-intervention data and random effects models.
abstract: The Anglia menorrhagia education study tests the effectiveness of an education package for the treatment of menorrhagia given to doctors at a primary care level. General practices were randomized to receive or not receive the package. It is hoped that this intervention will reduce the proportion of women suffering from menorrhagia that are referred to hospital. Data are available on the treatment and referral of women in the practices in the education and control groups, both pre- and post-intervention. We define and demonstrate a random effects logistic regression model that includes pre-intervention data for calculating the effectiveness of the intervention.
authors.affiliation: MRC Biostatistics Unit, Institute of Public Health, University Forvie Site, Robinson Way, Cambridge, CB2 2SR, UK. richard.nixon@mrc-bsu.cam.ac.uk
authors.forename: R M
authors.initials: RM
authors.lastname: Nixon
authors.forename: S W
authors.initials: SW
authors.lastname: Duffy
authors.forename: G R
authors.initials: GR
authors.lastname: Fender
authors.forename: N E
authors.initials: NE
authors.lastname: Day
authors.forename: T C
authors.initials: TC
authors.lastname: Prevost
mesh_terms: D005260:Female; D006801:Humans; D016015:Logistic Models; D008595:Menorrhagia / Q000628:therapy*; D008954:Models, Biological; D010821:Physicians, Family / Q000193:education*; D012017:Referral and Consultation; D012044:Regression Analysis; D006113:United Kingdom