title: AIDS-related body cavity-based lymphoma. A case report.
abstract: BACKGROUND
  Body cavity-based lymphomas are rare malignancies in human immunodeficiency virus (HIV)-infected patients, but because of their unusual clinical, morphologic and immunophenotypic features, they are recognized as a distinct subgroup of lymphomas connected to human herpesvirus 8 (HHV-8) infection.
  
  
  METHODS
  A 39-year-old, HIV-positive, homosexual man was admitted to the hospital because of a left-sided pleural effusion that contained malignant lymphoid cells. He responded partially to a low-dose cyclophosphamide/doxorubycin/vincristine/prednisone regimen and died five months after the diagnosis of lymphoma. On cytology, the sediments contained exclusively large, round, neoplastic, lymphoid cells with abundant basophilic cytoplasm and large, round nuclei with prominent nucleoli. Many cells had immunoblastic features, and some had plasmocytoid differentiation. Mitotic figures were numerous. On flow cytometry, the homogeneous population of large cells expressed CD45, CD38, HLA-DR and CD7 positivity. Other specific T-, B- and NK-cell markers tested negative. Polymerase chain reaction demonstrated Epstein-Barr virus (EBV) and HHV-8 in the malignant effusion.
  
  
  CONCLUSIONS
  Primary effusion from lymphoma with molecular evidence of HHV-8 and EBV coinfection represents a distinct clinical and morphologic entity in AIDS patients. However, immunophenotypic markers of malignant clones can be diverse in different cases.
authors.affiliation: Dr. Fran Mihaljević University Hospital for Infectious Diseases, Mirogojska 8, 10000 Zagreb, Croatia. avince@fran.bfm.hr
authors.forename: A
authors.initials: A
authors.lastname: Vince
authors.forename: J
authors.initials: J
authors.lastname: Begovac
authors.forename: H
authors.initials: H
authors.lastname: Kessler
authors.forename: H F
authors.initials: HF
authors.lastname: Rabenau
authors.forename: M
authors.initials: M
authors.lastname: Poljak
authors.forename: Z
authors.initials: Z
authors.lastname: Siftar
authors.forename: S
authors.initials: S
authors.lastname: Zidovec
authors.forename: T
authors.initials: T
authors.lastname: Jeren
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000821:virology; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D020031:Epstein-Barr Virus Infections / Q000150:complications / Q000821:virology; D006566:Herpesviridae Infections / Q000150:complications / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics / Q000302:isolation & purification; D019288:Herpesvirus 8, Human / Q000235:genetics / Q000302:isolation & purification; D006801:Humans; D016130:Immunophenotyping; D008223:Lymphoma / Q000150:complications / Q000473:pathology* / Q000821:virology*; D008297:Male; D016066:Pleural Effusion, Malignant / Q000150:complications / Q000473:pathology* / Q000821:virology*