title: A prospective case-control study of the role of astrovirus in acute diarrhea among hospitalized young children.
abstract: This study examines the importance of astroviruses as a cause of acute diarrhea in hospitalized children <10 years old during a 5-year period. Stools were screened by electron microscopy and were tested for astrovirus, rotavirus, and enteric adenovirus by EIA. During the study, 14.6% of hospitalized children had diarrhea. Astroviruses were second only to rotaviruses as etiologic agents of both community-acquired and nosocomial diarrhea. Community-acquired astrovirus infection occurred in 6.8% of patients, and nosocomial disease occurred in 16.2%. Most cases occurred from March through June, and astrovirus type 1 was the most common. The symptoms of astrovirus-infected children were similar to those of children with rotavirus infection. However, astrovirus-infected children had a lower median age, less dehydration, and lower symptom severity scores and were less likely to have been admitted for gastroenteritis than were children with rotavirus. Astrovirus, for which only rehydration therapy is required, should be considered as another common diarrheal pathogen in children <2 years old.
authors.affiliation: Department of Pediatrics, Rhode Island Hospital and Brown Medical School, Providence, Rhode Island 02903, USA. pdennehy@lifespan.org
authors.forename: P H
authors.initials: PH
authors.lastname: Dennehy
authors.forename: S M
authors.initials: SM
authors.lastname: Nelson
authors.forename: S
authors.initials: S
authors.lastname: Spangenberger
authors.forename: J S
authors.initials: JS
authors.lastname: Noel
authors.forename: S S
authors.initials: SS
authors.lastname: Monroe
authors.forename: R I
authors.initials: RI
authors.lastname: Glass
mesh_terms: D019350:Astroviridae Infections / Q000150:complications*; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D003967:Diarrhea / Q000209:etiology / Q000821:virology*; D005243:Feces / Q000821:virology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D001257:Mamastrovirus / Q000145:classification / Q000302:isolation & purification*; D011446:Prospective Studies; D012621:Seasons; D012703:Serotyping