title: Molecular cytogenetic characterization of an acquired minute supernumerary marker chromosome as the sole abnormality in a case clinically diagnosed as atypical Philadelphia-negative chronic myelogenous leukaemia.
abstract: A case of chronic myelogenous leukaemia (CML) in a 48-year-old man is reported. To the best of our knowledge, this is the first report of a Philadelphia-negative CML with an acquired small supernumerary marker chromosome (SMC) 11 as the sole abnormality. The derivative chromosome 11 was studied in detail using molecular cytogenetic methods; fluorescence in situ hybridization (FISH) using centromere- and region-specific probes for chromosome 11, microdissection, micro-comparative genomic hybridization (micro-CGH) and the recently developed multicolour banding (MCB) technique. The acquired SMC was determined to be a ring chromosome that can be described as r(11)(:p11.2-->q13.1:q14:).
authors.affiliation: Institute of Human Genetics and Anthropology, Friedrich Schiller University, Jena, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Starke
authors.forename: M
authors.initials: M
authors.lastname: Raida
authors.forename: V
authors.initials: V
authors.lastname: Trifonov
authors.forename: J H
authors.initials: JH
authors.lastname: Clement
authors.forename: I F
authors.initials: IF
authors.lastname: Loncarevic
authors.forename: A
authors.initials: A
authors.lastname: Heller
authors.forename: C
authors.initials: C
authors.lastname: Bleck
authors.forename: A
authors.initials: A
authors.lastname: Nietzel
authors.forename: N
authors.initials: N
authors.lastname: Rubtsov
authors.forename: U
authors.initials: U
authors.lastname: Claussen
authors.forename: T
authors.initials: T
authors.lastname: Liehr
mesh_terms: D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D005819:Genetic Markers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D054438:Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative / Q000235:genetics*; D008297:Male; D008875:Middle Aged
chemical_list: D005819:Genetic Markers