[Influence of glucocorticoid steroid therapy on gastric and duodenal mucosa and Helicobacter pylori infection in children with nephrotic syndrome].
The purpose of the study was to evaluate the influence of steroid therapy on endoscopic picture of gastric mucosa. The study comprised 22 children (17 boys and 5 girls) with the nephrotic syndrome aged 4-12 years (the mean 9 years) treated with prednisone. Children were divided into two groups taking into account duration of therapy. The group I (10 children) comprised patients with therapy duration not exceeding 3 months. The group II (12 children) comprised children treated 5 years in average. All patients underwent gastroscopic examination. Macro and microscopic lesions of gastric mucosa, their intensity and coexistence of Helicobacter pylori (HP) infection were estimated.


CONCLUSIONS
1. In nephrotic children during prednisone therapy different types of gastric and duodenal mucosal inflammatory changes occur. 2. Duration of prednisone therapy does not influence significantly on location, type and severity of mucosal inflammatory changes. 3. Frequency of coexistent HP infection increases with prednisone therapy duration. 4. Prednisone therapy of nephrotic children is indication for gastric and duodenal endoscopic examination.
Zajaczkowska
M
M
Klinika Pediatrii i Nefrologii DSK AM w Lublinie.
Papierkowski
A
A
Szczepanowska
A
A
Zinkiewicz
Z
Z
Borzecka
H
H
Zbarańska
S
S
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018450:Disease Progression; D004382:Duodenitis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000473:pathology; D005756:Gastritis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D005773:Gastroscopy; D005938:Glucocorticoids / Q000627:therapeutic use*; D016481:Helicobacter Infections / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008297:Male; D009404:Nephrotic Syndrome / Q000150:complications*; D011241:Prednisone / Q000627:therapeutic use*
D005938:Glucocorticoids; D011241:Prednisone