Does the natriuretic peptide system exist throughout the animal and plant kingdom?
Natriuretic peptides (NPs) and their receptors have been identified in vertebrate species ranging from elasmobranchs to mammals. Atrial, brain and ventricular NP (ANP, BNP and VNP) are endocrine hormones secreted from the heart, while C-type NP (CNP) is principally a paracrine factor in the brain and periphery. In elasmobranchs, only CNP is present in the heart and brain and it functions as a circulating hormone as well as a paracrine factor. Four types of NP receptors are cloned in vertebrates. NPR-A and NPR-B are guanylyl cyclase-coupled receptors, whereas NPR-C and NPR-D have only a short cytoplasmic domain. NPs are hormones important for volume regulation in mammals, while they act more specifically for Na(+) regulation in fishes. The presence of NP and its receptor has also been suggested in the most primitive vertebrate group, cyclostomes, and its molecular identification is in progress. The presence of ANP or its mRNA has been reported in the hearts and ganglia of various invertebrate species such as mollusks and arthropods using either antisera raised against mammalian ANP or rat ANP cDNA as probes. Immunoreactive ANP has also been detected in the unicellular Paramecium and in various species of plants including Metasequoia. Furthermore, the N-terminal prosegments of ANP, whose sequences are scarcely conserved even in vertebrates, have also been detected by the radioimmunoassay for human ANP prosegments in all invertebrate and plant species examined including Paramecium. Although these data are highly attractive, the current evidence is too circumstantial to be convincing that the immunoreactivity truly originates from ANP and its prosegments in such diverse organisms. The caution that has to be exercised in identification of vertebrate hormones from phylogenetically distant organisms is discussed.
Takei
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Division of Physiology, Department of Marine Bioscience, Ocean Research Institute, the University of Tokyo, 1-15-1 Minamidai, Nakano, 164-8639, Tokyo, Japan. takei@ori.u-tokyo.ac.jp
D000595:Amino Acid Sequence; D000818:Animals; D006162:Guanylate Cyclase / Q000737:chemistry / Q000378:metabolism; D007448:Invertebrates / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data; D045283:Natriuretic Agents / Q000737:chemistry / Q000378:metabolism*; D010944:Plants / Q000737:chemistry / Q000378:metabolism*; D017461:Receptors, Atrial Natriuretic Factor / Q000737:chemistry / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D014714:Vertebrates / Q000378:metabolism
D045283:Natriuretic Agents; D006162:Guanylate Cyclase; D017461:Receptors, Atrial Natriuretic Factor; C073616:atrial natriuretic factor receptor C