Gynaecomastia in a male patient during stavudine and didanosine treatment for HIV infection.
We report a case of gynaecomastia developed in a HIV-seropositive man, associated with a severe lipodystrophy. We hypothesize the responsibility of stavudine and didanosine in the development of these 2 complications. If many reports suggest that the protease inhibitors may promote gynaecomastia, long-term nucleoside analogue therapy may also cause this side effect.
Aquilina
C
C
Service de Dermato-vénéréologie, Hôpital La Grave, Place Lange, 31052 Toulouse Cédex, France.
Viraben
R
R
D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D016049:Didanosine / Q000009:adverse effects*; D006177:Gynecomastia / Q000139:chemically induced*; D015658:HIV Infections / Q000150:complications* / Q000188:drug therapy; D006679:HIV Seropositivity / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008060:Lipodystrophy / Q000139:chemically induced; D008297:Male; D018119:Stavudine / Q000009:adverse effects*
D019380:Anti-HIV Agents; D018119:Stavudine; D016049:Didanosine