Simvastatin-associated memory loss.
The statins are widely used to treat dyslipidemias. They are generally associated with mild adverse effects, but rarely, more serious reactions may occur. A 51-year-old man experienced delayed-onset, progressive memory loss while receiving simvastatin for hypercholesterolemia. His therapy was switched to pravastatin, and memory loss resolved gradually over the next month, with no recurrence of the adverse effect.
Orsi
A
A
Pharmacy Program, Bronx VA Medical Center, New York 10468, USA.
Sherman
O
O
Woldeselassie
Z
Z
D000924:Anticholesteremic Agents / Q000009:adverse effects*; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D008875:Middle Aged; D017035:Pravastatin / Q000494:pharmacology / Q000627:therapeutic use; D020127:Recovery of Function / Q000187:drug effects; D019821:Simvastatin / Q000009:adverse effects* / Q000627:therapeutic use
D000924:Anticholesteremic Agents; D019821:Simvastatin; D017035:Pravastatin