[Kallikrein-kinin system: novel facts and concepts (literature review)].
The kallikrein-kinin system (KKS) is the key proteolytic system participating in control of a wide spectrum of physiological functions and the development of many pathological conditions. This explains great interest in structures, functions and molecular biology of separate components of the system, molecular mechanisms of their interaction and relationship with other regulatory systems. The information in this field for the last two decades clarifies the role of KKS in morphogenesis of cells, regulation of smooth muscular contractility of some organs, decrease of blood pressure, increase of vascular permeability, the development of inflammation, transformation of cells and the other functions of both physiological and pathological processes. Essential progress in understanding of functions KKS was made by the discovery and study of bradykinin receptors, cloning of kininogen and kallikrein encoding genes, revealing of domain structure of kininogen, prekallikrein and some kininase and decoding of mechanisms of contact phase of proteolytic system activation in blood plasma.
Iarovaia
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Russian Postgraduate Medical Academy, 2 Barrikadnaya str., Moscow, 123836 Russia. yarov@cardpl.msk.ru
D000595:Amino Acid Sequence; D006801:Humans; D016234:Kallikrein-Kinin System / Q000502:physiology*; D007704:Kininogens / Q000097:blood; D008969:Molecular Sequence Data; D011288:Prekallikrein / Q000737:chemistry; D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin / Q000502:physiology
D007704:Kininogens; D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin; D011288:Prekallikrein