GABA in the Mammalian Enteric Nervous System.
gamma-Aminobutyric acid (GABA) is a transmitter of enteric interneurons, targeting excitatory GABA(A) or inhibitory GABA(B) receptors that modulate motility and mucosal function. Enteric GABA may also subserve hormonal and paracrine signaling. Disruption in gastrointestinal function following perturbation of enteric GABA receptors presents potential new target sites for drug development.
Krantis
Anthony
A
Department of Cellular and Molecular Medicine, Digestive Diseases Research Group, University of Ottawa, Ottawa, ON, Canada K1H 8M5.