The ether-à-go-go-Related Gene K(+) Current: Functions of a Strange Inward Rectifier.
The erg channels mediate an inward-rectifying K(+) current because of their peculiar gating kinetics. They are involved in repolarization of the cardiac action potential, frequency adaptation, and maintenance of the resting potential. Reduction of erg currents via an intracellular signal cascade underlies the thyrotropin-releasing hormone-induced increase in prolactin secretion.
Schwarz
Jürgen R.
JR
Abteilung für angewandte Physiologie, Physiologisches Institut, Universitäts-Krankenhaus Eppendorf, Universität Hamburg, D-20246 Hamburg, Germany.
Bauer
Christiane K.
CK