Relaxin is essential for renal vasodilation during pregnancy in conscious rats.
Marked vasodilation in the kidney and other nonreproductive organs is one of the earliest maternal adaptations to occur during pregnancy. Despite the recognition of this extraordinary physiology for over four decades, the gestational hormone responsible has remained elusive. Here we demonstrate a key role for relaxin, a member of the IGF family that is secreted by the corpus luteum in humans and rodents. Using a gravid rodent model, we employ two approaches to eliminate relaxin or its biological activity from the circulation: ovariectomy and administration of neutralizing antibodies. Both abrogate the gestational elevation in renal perfusion and glomerular filtration, as well as preventing the reduction in myogenic reactivity of isolated, small renal arteries. Osmoregulatory changes, another pregnancy adaptation, are also abolished. Our results indicate that relaxin mediates the renal vasodilatory responses to pregnancy and thus may be important for maternal and fetal health. They also raise the likelihood of a role for relaxin in other cardiovascular changes of pregnancy, and they suggest that, like estrogen, relaxin should be considered a regulator of cardiovascular function.
Novak
J
J
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of Pittsburgh School of Medicine, and Magee-Women's Research Institute, Pittsburgh, Pennsylvania, USA.
Danielson
L A
LA
Kerchner
L J
LJ
Sherwood
O D
OD
Ramirez
R J
RJ
Moalli
P A
PA
Conrad
K P
KP
D000818:Animals; D000906:Antibodies / Q000276:immunology; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000502:physiology*; D008297:Male; D010052:Ovariectomy; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000502:physiology*; D051381:Rats; D020318:Rats, Long-Evans; D012065:Relaxin / Q000276:immunology / Q000502:physiology*; D012077:Renal Artery / Q000033:anatomy & histology / Q000502:physiology*; D012079:Renal Circulation / Q000502:physiology*; D014664:Vasodilation
D000906:Antibodies; D012065:Relaxin