[A possibility to predict the severity of individual damage following the exposure to supralethal radiation dosage. Prediction of the clinical manifestation of radiation injury in laboratory animals by response to pre-exposure hypobaric hypoxia].
The experiments on rats, dogs and monkeys exposed to radiation doses which cause intestinal and cerebral forms of radiation sickness have shown that the severity of a clinical state can be predicted by cardiovascular and endocrine changes when a pre-exposure test with moderate hypobaric hypoxia is performed. The goodness of fit of experimental data to the exposed result is up to 60-80%, still rising if a set of indices of the neuroendocrine status is used.
Darenskaia
N G
NG
State Research Centre of Russia-Institute of Biophysics, Moscow, 123182 Russia.
Korotkevich
A O
AO
Nasonova
T A
TA
Maliutina
T S
TS
D000818:Animals; D004285:Dogs; D000860:Hypoxia / Q000503:physiopathology*; D008252:Macaca fascicularis; D008297:Male; D011237:Predictive Value of Tests; D011379:Prognosis; D011832:Radiation Injuries / Q000503:physiopathology*; D051381:Rats; D012720:Severity of Illness Index