title: (S)-(-)-Bromofosfamide (CBM-11): synthesis and antitumor activity and toxicity in mice.
abstract: (S)-(-)-Bromofosfamide (CBM-11), an enantiomerically pure bromo analog of ifosfamide, was found to be potent against several model tumors in mice. Therapeutic indices of CBM-11 were more favorable as compared to those received for ifosfamide.
authors.affiliation: Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Sienkiewicza 112, 90-363 Lódz, Poland. kmisiura@bio.cbmm.lodz.pl
authors.forename: K
authors.initials: K
authors.lastname: Misiura
authors.forename: R W
authors.initials: RW
authors.lastname: Kinas
authors.forename: H
authors.initials: H
authors.lastname: Kuśnierczyk
authors.forename: C
authors.initials: C
authors.lastname: Radzikowski
authors.forename: W J
authors.initials: WJ
authors.lastname: Stec
mesh_terms: D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000138:chemical synthesis* / Q000627:therapeutic use*; D001682:Biological Availability; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy*; D002851:Chromatography, High Pressure Liquid; D003433:Crosses, Genetic; D005260:Female; D007069:Ifosfamide / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D007939:Leukemia L1210 / Q000188:drug therapy*; D008546:Melanoma, Experimental / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D015394:Molecular Structure
chemical_list: D018906:Antineoplastic Agents, Alkylating; C073801:bromofosfamide; D007069:Ifosfamide