title: [Ropivacaine 0.2% versus bupivacaine 0.125% plus sufentanil for continuous peridural analgesia following extended abdominal operations].
abstract: OBJECTIVE
  An improved opioid-free analgesia concept using thoracic epidural anlgesia with a low concentrated local anaesthetic alone could be of practical interest for hospitals which are unable to guarantee continuous monitoring on the wards.
  
  
  METHODS
  We have compared in a prospective, randomized, double-blind study, the analgesic effects and side effects of ropivacaine 0.2% (Group 1) with bupivacaine 0.125% plus 0.5 microgram ml-1 sufentanil (Group 2) via a thoracic epidural catheter during the first 24 hours after major abdominal surgery in 28 gynaecological tumour patients. Assessments were performed 8, 12, 16, 20 and 24 hours after surgery.
  
  
  RESULTS
  No differences were seen in duration of surgery, intraoperative opioid and supplemental analgesic requirements. As a main result VAS values for pain during mobilisation were higher in Group 1 when compared with Group 2 (p < 0.01) after 20 and 24 hours of continuous epidural infusion (10 ml h-1) whereas VAS values at rest were comparable (p < 0.1) at all measurepoints. Intensity of motor block and side effects did not differ between groups.
  
  
  CONCLUSIONS
  The present study shows that continuous epidural infusion of 0.2% ropivacaine alone provides comparable analgesia at rest, but less profound pain relief during mobilisation within the first 24 hours after major abdominal surgery than bupivacaine 0.125% with sufentanil.
authors.affiliation: Klinik und Poliklinik für Anästhesiologie, Universitätsklinikum Hamburg-Eppendorf. burmeister@uke.uni-hamburg.de
authors.forename: M A
authors.initials: MA
authors.lastname: Burmeister
authors.forename: A
authors.initials: A
authors.lastname: Gottschalk
authors.forename: S
authors.initials: S
authors.lastname: Wilhelm
authors.forename: F
authors.initials: F
authors.lastname: Schroeder
authors.forename: C
authors.initials: C
authors.lastname: Becker
authors.forename: T
authors.initials: T
authors.lastname: Standl
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000368:Aged; D000577:Amides / Q000009:adverse effects; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D000767:Anesthesia, Epidural / Q000009:adverse effects; D000779:Anesthetics, Local / Q000009:adverse effects; D002045:Bupivacaine / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D011446:Prospective Studies; D000077212:Ropivacaine; D017409:Sufentanil / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D000577:Amides; D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D000077212:Ropivacaine; D017409:Sufentanil; D002045:Bupivacaine