title: [Relationship between expression of P16 protein and prognosis in carcinoma of nasopharynx].
abstract: We observed the relationship between p16 gene and the occurrence, development and prognosis of carcinoma of nasopharynx by means of LSAB immunohistochemistry method and investigated the expression of protein P16 in 73 cases of carcinoma of nasopharynx and 10 cases of epithelia of chronic inflammation of nasopharynx. The results showed that P16 positive rate was 100% for the epithelia of chronic inflammation of nasopharynx. It was significantly higher than the P16 positive rate for the carcinoma of nasopharynx (38.4%, P < 0.01). There was significant difference of P16 positive expression in differentiation of nasopharyngeal carcinoma (poor differentiation versus undifferentiation), clinical staging (I-II versus IV) and grading of tumor (T1-T2 versus T3, T4) (P < 0.01). There was no correlation between P16 expression and metastatic lymph node (P > 0.05). The 3-year survival rates were 88.9% and 72.9% in P16 expression (+) and (-) patients respectively (P < 0.05). These findings suggested that P16 might play an important role in the process of carcinogenesis and development of nasopharyngeal carcinoma, and P16 might be used as a valuable marker for assessment of the biological behavior and prognosis of nasopharyngeal carcinoma.
authors.affiliation: Department of Otolaryngology, First Affiliated Hospital, WCUMS, Chengdu 610041.
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Yao
authors.forename: S
authors.initials: S
authors.lastname: Zhang
authors.forename: C
authors.initials: C
authors.lastname: Liang
authors.forename: N
authors.initials: N
authors.lastname: Cheng
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism*; D019941:Cyclin-Dependent Kinase Inhibitor p16 / Q000096:biosynthesis*; D005260:Female; D019942:Genes, p16; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000235:genetics / Q000378:metabolism*; D011379:Prognosis
chemical_list: D019941:Cyclin-Dependent Kinase Inhibitor p16