title: Late onset of severe graft-versus-host disease in a pediatric liver transplant recipient.
abstract: We report the management of a patient with the late onset of chronic graft-versus-host disease (GVHD) after orthotopic liver transplantation. GVHD is a rare complication of solid organ transplants that usually presents early after transplantation and is fatal in the majority of cases. Our patient differs from the typical patient with GVHD in that the onset of her disease was very late. Although most treatment to date consisted of an increase in immunosuppressive therapy, our patient showed an excellent response to a reduction. This resulted in the abatement of the symptoms of GVHD and the preservation of her allograft function.
authors.affiliation: Division of Solid Organ Transplantation, Department of Surgery, 1600 Rockland Road, Wilmington, DE 19899, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Dunn
authors.forename: L J
authors.initials: LJ
authors.lastname: Krueger
authors.forename: L
authors.initials: L
authors.lastname: Butani
authors.forename: H
authors.initials: H
authors.lastname: Punnett
mesh_terms: D004305:Dose-Response Relationship, Drug; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects*; D012720:Severity of Illness Index
chemical_list: D007166:Immunosuppressive Agents