A model of combined gastroduodenitis and hyperlipidemia in rats.
We elaborated a model of gastroduodenitis combined with hyperlipidemia in rats. This model is based on alimentary lipid disturbances and morphological changes in the gastroduodenal mucosa caused by exogenous damaging factors. Morphological assay revealed gastroduodenitis; biochemical studies of the blood and liver demonstrated hyperlipidemia. This model holds much promise for evaluating pathogenetic mechanisms of combined gastroduodenal and heart diseases.
Knyshova
V V
VV
Institute of Medical Climatology and Rehabilitation Therapy, Vladivostok Branch, Far-Eastern Research Center of Physiology and Pathology of Respiration, Siberian Division of the Russian Academy of Medical Sciences, Vladivostok, Russia.
Ivanova
I L
IL
Kapitonova
V G
VG
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D005759:Gastroenteritis / Q000139:chemically induced / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D006949:Hyperlipidemias / Q000139:chemically induced / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D008055:Lipids / Q000097:blood; D008099:Liver / Q000737:chemistry; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D008055:Lipids