title: Functional recovery after brain lesion--contralateral neuromodulation: an fMRI study.
abstract: Behavioral recovery takes place even after permanent damage to the entire brain region normally controlling sensorimotor hind limb function in the rat. In our study, 2 weeks after full behavioral recovery from an experimental unilateral permanent brain damage, the topographic representation of the previous paretic hindlimb was investigated by fMRI. The analysis showed that during electrical stimulation of the previously paretic hindlimb, two normally inactive brain regions were now being activated. One region was the non-damaged contralateral sensori-motor cortex and the other region was located lateral to the lesion. These results suggest that behavioral recovery can be explained by functional reorganization and neuromodulation of the brain.
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Abo
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
authors.forename: L J
authors.initials: LJ
authors.lastname: Lai
authors.forename: T
authors.initials: T
authors.lastname: Reese
authors.forename: B
authors.initials: B
authors.lastname: Bjelke
mesh_terms: D000344:Afferent Pathways / Q000293:injuries / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001930:Brain Injuries / Q000473:pathology / Q000503:physiopathology* / Q000534:rehabilitation; D002560:Cerebrovascular Circulation / Q000502:physiology; D003714:Denervation; D007839:Functional Laterality / Q000502:physiology*; D006614:Hindlimb / Q000294:innervation / Q000502:physiology; D008279:Magnetic Resonance Imaging; D008297:Male; D009069:Movement Disorders / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation; D009416:Nerve Regeneration / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D010291:Paresis / Q000473:pathology / Q000503:physiopathology / Q000534:rehabilitation; D010775:Photic Stimulation / Q000009:adverse effects; D010777:Photochemistry / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology*; D012395:Rose Bengal; D013003:Somatosensory Cortex / Q000293:injuries / Q000473:pathology / Q000503:physiopathology*
chemical_list: D012395:Rose Bengal