Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls.
A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.
Sklar
P
P
Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. sklar@genome.wi.mit.edu
Schwab
S G
SG
Williams
N M
NM
Daly
M
M
Schaffner
S
S
Maier
W
W
Albus
M
M
Trixler
M
M
Eichhammer
P
P
Lerer
B
B
Hallmayer
J
J
Norton
N
N
Williams
H
H
Zammit
S
S
Cardno
A G
AG
Jones
S
S
McCarthy
G
G
Milanova
V
V
Kirov
G
G
O'Donovan
M C
MC
Lander
E S
ES
Owen
M J
MJ
Wildenauer
D B
DB
D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D000074562:Receptor, Notch4; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D012559:Schizophrenia / Q000235:genetics*; D006113:United Kingdom
C106075:NOTCH4 protein, human; D011518:Proto-Oncogene Proteins; D000074562:Receptor, Notch4; D011956:Receptors, Cell Surface; D051880:Receptors, Notch