Physiology of Receptor-Mediated Lymphocyte Apoptosis.
Apoptosis (programmed cell death), a physiological mechanism eliminating abundant and potentially harmful cells, is triggered by a variety of stimuli including activation of distinct receptors. The machinery mediating CD95 receptor-induced apoptosis includes caspases, ceramide, kinases, Ras and Rac, formation of O(2)(-), mitochondrial proteins, inhibition of K(+) channels, activation of Cl(-) channels, and osmolyte release.
Lang
F.
F
Department for Physiology of the University of Tübingen, Gmelinstrasse 5, D-72076 Tübingen, Germany.
Szabo
I.
I
Lepple-Wienhues
A.
A
Siemen
D.
D
Gulbins
E.
E