Triple-bonded unsaturated fatty acids are redox active compounds.
Unsaturated fatty acids with triple bonds are used as inhibitors of unsaturated fatty acid metabolism or cytochrome P450 reactions because they are believed to be chemically inert. In this paper we use in vitro cytochrome C reduction to show that two commonly used triple-bonded unsaturated fatty acids are in fact potent electron transfer agents and could affect the multiple cellular systems that are redox-modulated.
Peterson
D A
DA
Department of Medicine, VA Medical Center, Minneapolis, Minnesota 55417, USA. peter002@tc.umn.edu
Reeve
H L
HL
Nelson
D
D
Archer
S L
SL
Weir
E K
EK
D015117:5,8,11,14-Eicosatetraynoic Acid / Q000737:chemistry / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000494:pharmacology; D003574:Cytochrome c Group / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D004579:Electron Transport; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000737:chemistry; D007700:Kinetics; D019301:Oleic Acid / Q000494:pharmacology; D010084:Oxidation-Reduction
D003574:Cytochrome c Group; D005231:Fatty Acids, Unsaturated; D005296:Ferrous Compounds; D015117:5,8,11,14-Eicosatetraynoic Acid; D016718:Arachidonic Acid; D019301:Oleic Acid; C047008:17-octadecynoic acid