Influence of inositolhexaphosphori acid (phytic acid) on the copper distribution in tissues and the excretion of copper in rats.
The aim of the present study was to investigate the effect of the administration of phytic acid on copper (Cu) concentrations in several different rat tissues. The animals used were divided into three groups: Group A (received a diet supplemented with 2% phytic acid), group B (received a diet supplemented with 10% phytic acid) and group C (control). At the end of the experiment, the animals were sacrificed and the concentration of copper was determined in the different tissues. Phytic acid significantly increased Cu concentration in the duodenum of the animals of both groups as well as in the lungs and blood of the animals of group A. The copper concentration was also increased in the uterus and bone of the animals of group B. On the other hand, the stomach copper concentration of the animals of both groups, the heart and lung copper concentrations of the animals of group B as well as the jejunum, colon and hair copper concentrations of the animals of group A were significantly decreased. Copper excretion through feces was significantly decreased in the animals of both groups, while the excretion through urine was not significantly affected by the administration of phytic acid. In conclusion, the administration of phytic acid can produce translocation and/or elimination of copper in various tissues of rats.
Kotsaki-Kovatsi
V P
VP
Laboratoty of Biochemistry and Toxicology, Faculty of Veterinary Medicine, Aristotle University, Thessaloniki, Macedonia, Greece.
Kovatsi
L
L
Koehler-Samouilidou
G
G
Karavanis
M
M
Bacoyanni
E
E
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D003300:Copper / Q000378:metabolism* / Q000493:pharmacokinetics; D004386:Duodenum / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006197:Hair / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010833:Phytic Acid / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D014599:Uterus / Q000378:metabolism
D003300:Copper; D010833:Phytic Acid