Lack of p53 accelerates hepatocarcinogenesis in transgenic mice constitutively overexpressing c-myc in the liver.
Klocke
R
R
Fraunhofer Institute of Toxicology and Aerosol Research, Department of Cell Biology, D-30625 Hannover, Germany. rainer.klocke@ingenium-ag.com
Bartels
T
T
Jennings
G
G
Brand
K
K
Halter
R
R
Strauss
M
M
Paul
D
D
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000209:etiology* / Q000401:mortality; D002471:Cell Transformation, Neoplastic; D020022:Genetic Predisposition to Disease; D008099:Liver / Q000378:metabolism; D008113:Liver Neoplasms / Q000209:etiology* / Q000401:mortality; D051379:Mice; D008822:Mice, Transgenic; D008954:Models, Biological; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis* / Q000235:genetics; D016019:Survival Analysis; D016159:Tumor Suppressor Protein p53 / Q000172:deficiency* / Q000235:genetics
D016271:Proto-Oncogene Proteins c-myc; D016159:Tumor Suppressor Protein p53