title: [A disseminated form of Langerhans histiocytosis associated with diabetes insipidus and diabetes mellitus].
abstract: BACKGROUND
  Langerhans' cell histiocytosis is a rare disorder of unknown etiology characterized by a wide clinical spectrum and varied behavior. Diabetes insipidus is a relatively common feature in Langerhans' cell histiocytosis. The presence of both diabetes insipidus and mellitus associated with histiocytosis in an adult is rare. To our knowledge, only three previous cases have been reported.
  
  
  METHODS
  We report the clinical presentation, pathologic findings and clinical progress in an adult female who had disseminated Langerhans' cell histiocytosis (hypothalamic infiltration, multifocal bone involvement) associated with both diabetes insipidus and mellitus.
  
  
  CONCLUSIONS
  The pathogenesis of diabetes mellitus in such an association will be discussed.
authors.affiliation: Service de médecine interne, hôpital La Rabta, 1007 Tunis, Tunisie.
authors.forename: I
authors.initials: I
authors.lastname: Ben Ghorbel
authors.forename: M H
authors.initials: MH
authors.lastname: Houman
authors.forename: S
authors.initials: S
authors.lastname: B'chir
authors.forename: S
authors.initials: S
authors.lastname: Chamakhi
authors.forename: M
authors.initials: M
authors.lastname: Miled
mesh_terms: D000328:Adult; D001706:Biopsy; D001847:Bone Diseases / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D003919:Diabetes Insipidus / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D003920:Diabetes Mellitus / Q000097:blood / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007027:Hypothalamic Diseases / Q000097:blood / Q000150:complications* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D011141:Polyuria / Q000209:etiology; D013894:Thirst; D014057:Tomography, X-Ray Computed