title: The expression pattern of tomoregulin-1 in urodele limb regeneration and mouse limb development.
abstract: Tomoregulin-1 (TMEFF1) was first identified as a gene implicated in pituitary secretion in Xenopus laevis. The predicted structure of TMEFF1 is that of a transmembrane protein with a highly conserved cytoplasmic tail, two follistatin domains and one modified EGF domain in its extracellular region. We report the cloning of the newt orthologue, and show that the expression of TMEFF1 is upregulated in the blastema during limb regeneration, and is also expressed in mouse embryonic limb development.
authors.affiliation: Department of Biochemistry and Molecular Biology, University College London, Gower Street, London WC1E 6BT, UK.
authors.forename: S
authors.initials: S
authors.lastname: Morais da Silva
authors.forename: P B
authors.initials: PB
authors.lastname: Gates
authors.forename: D W
authors.initials: DW
authors.lastname: Eib
authors.forename: G J
authors.initials: GJ
authors.lastname: Martens
authors.forename: J P
authors.initials: JP
authors.lastname: Brockes
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D019556:COS Cells; D002462:Cell Membrane / Q000378:metabolism; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D005121:Extremities / Q000196:embryology / Q000502:physiology; D006801:Humans; D017403:In Situ Hybridization; D008565:Membrane Proteins / Q000096:biosynthesis*; D051379:Mice; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins; D021382:Protein Sorting Signals; D017434:Protein Structure, Tertiary; D012333:RNA, Messenger / Q000378:metabolism; D012038:Regeneration; D012260:Ribonucleases / Q000378:metabolism; D012455:Salamandridae; D017386:Sequence Homology, Amino Acid; D014162:Transfection; D015854:Up-Regulation; D014981:Xenopus; D029867:Xenopus Proteins
chemical_list: D018076:DNA, Complementary; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D021382:Protein Sorting Signals; D012333:RNA, Messenger; C101124:TMEFF1 protein, Xenopus; C423567:TMEFF2 protein, human; C486585:Tmeff1 protein, mouse; D029867:Xenopus Proteins; D012260:Ribonucleases