Chemoprotective effect of Ixora coccinea L. flowers on cisplatin induced toxicity in mice.
The active fraction from Ixora coccinea flowers prevented a decrease in body weight, haemoglobin levels and leucocyte counts of mice treated with cisplatin. It also significantly prolonged the life span of cisplatin treated mice and maintained their blood urea nitrogen levels in the near normal range, indicating its chemoprotective effects.
Latha
P G
PG
Ethnomedicine and Ethnopharmacology Division, Tropical Botanic Garden and Research Institute, Palode, Trivandrum-695 562, India.
Panikkar
K R
KR
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001806:Blood Urea Nitrogen; D002945:Cisplatin / Q000633:toxicity*; D006454:Hemoglobins / Q000187:drug effects*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D020011:Protective Agents / Q000494:pharmacology*; D019666:Rubiaceae
D000970:Antineoplastic Agents; D006454:Hemoglobins; D010936:Plant Extracts; D020011:Protective Agents; D002945:Cisplatin