Sphinganine in sphingomyelins of tumors and mouse regenerating liver.
Contents of sphingenine (sphingosine) and sphinganine were studied in sphingomyelins of transplantable mouse tumors (hepatoma-22, melanoma B16, Lewis lung carcinoma, intestine carcinoma) and rat nephroma RA. The content of sphinganine was increased in sphingomyelins of hepatoma-22 and nephroma RA compared to sphingomyelins of liver and kidneys. Significant contents of sphinganine were also found in sphingomyelins of other studied tumors. The content of sphinganine in regenerating mouse liver (30 h after hepatectomy) was normal. The data suggest that disorders should exist in biosynthesis of sphingoid bases in tumors but not in normal rapidly proliferating tissue.
Dyatlovitskaya
E V
EV
Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117871, Russia. dyatl@ibch.ru
Kandyba
A G
AG
Kozlov
A M
AM
Somova
O G
OG
D000818:Animals; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000737:chemistry* / Q000502:physiology; D008115:Liver Regeneration; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000737:chemistry*; D013109:Sphingomyelins / Q000737:chemistry*; D013110:Sphingosine / Q000031:analogs & derivatives* / Q000032:analysis*
D013109:Sphingomyelins; D013110:Sphingosine; C005682:safingol