[Age, environmental factors, and hormonal carcinogenesis].
In this paper modern concepts of hormonal carcinogenesis are discussed. Distinguishing of the latter into 2 principal types (promotional and genotoxic) is supported. The role of age, aging and effect of environmental factors in the choice of hormonal carcinogenesis type (as well as for the creation of "estrogenic effect switching/overtargeting phenomenon") is underlined. Mentioned phenomenon is manifested by the weakening of endocrine (hormonal) effects of estrogens together with intensification of genotoxic (DNA-damaging) effect of their metabolites. Conclusion is made that both the conditions favoring hormone-dependent tumors development and the direct mechanisms of hormonal carcinogenesis may be considerably modulated on different stages of ontogenesis and by the influence of environmental factors that is to be taken into considerations while choosing methods for oncological diseases prevention.
Bershteĭn
L M
LM
N.N. Petrov Research Institute of Oncology, St. Petersburg, Russia 197758.
D000375:Aging / Q000473:pathology*; D002273:Carcinogens / Q000633:toxicity*; D004249:DNA Damage; D004781:Environmental Exposure; D006801:Humans; D009153:Mutagens / Q000633:toxicity*; D009376:Neoplasms, Hormone-Dependent / Q000209:etiology*
D002273:Carcinogens; D009153:Mutagens