title: Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase.
abstract: The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 22 females) and 358 consecutive newborns (194 males and 164 females). cLMWPTP phenotypes showing a high concentration of F isoforms are associated with CD in females and with UC in males. Since PTPases counteract the effects of protein tyrosines kinases, a high concentration of F isoform of cLMWPTP may influence the mucosal response to pathogenic factors, increasing susceptibility to CD in females and to UC in males.
authors.affiliation: Division of Allergology and Clinical Immunology, University of Rome Tor Vergata School of Medicine, Rome, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Bottini
authors.forename: F
authors.initials: F
authors.lastname: Gloria-Bottini
authors.forename: N
authors.initials: N
authors.lastname: Lucarini
authors.forename: P G
authors.initials: PG
authors.lastname: Ronchetti
authors.forename: L
authors.initials: L
authors.lastname: Fontana
mesh_terms: D003093:Colitis, Ulcerative / Q000201:enzymology / Q000235:genetics; D003424:Crohn Disease / Q000201:enzymology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D018392:Genomic Imprinting; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D015212:Inflammatory Bowel Diseases / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D010641:Phenotype; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor / Q000502:physiology; D012384:Rome / Q000453:epidemiology; D012727:Sex Characteristics; D015398:Signal Transduction / Q000235:genetics*
chemical_list: D007527:Isoenzymes; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases