title: Myocardial revascularization as a therapeutic strategy in the patient with advanced ventricular dysfunction.
abstract: The number of patients with severe ventricular dysfunction from coronary artery disease is constantly increasing. Although the medical management of these patients with angiotensin-converting enzyme inhibitors and beta-blockers has favorable impact on the morbidity and mortality the overall prognosis is still poor. Historically many of these patients have been referred for transplantation. In the past few years there has been an increasing amount of information about the utility of surgical revascularization in patients with low ejection fraction. Careful patient selection and optimal perioperative management is of critical importance for good outcome. Coronary artery bypass grafting (CABG) can be performed relatively safely despite the advanced level of left ventricular dysfunction. Quality of life is improved by CABG with elimination of angina and enhanced functional capacity. Improvement in the ejection fraction and increased survival after the operation has been objectively demonstrated. However patients with advanced right ventricular dysfunction, pulmonary hypertension, redo bypass and ungraftable coronaries should be considered for heart transplantation. In this review we describe our experience and focus on pertinent issues in patient selection, perioperative management and long term outcome after coronary artery bypass grafting.
authors.affiliation: Section of Cardiothoracic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520-8039, USA.
authors.forename: F A
authors.initials: FA
authors.lastname: Mitropoulos
authors.forename: J A
authors.initials: JA
authors.lastname: Elefteriades
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications; D005260:Female; D006801:Humans; D008297:Male; D018579:Patient Selection; D019990:Perioperative Care; D013997:Time Factors; D016896:Treatment Outcome; D018754:Ventricular Dysfunction / Q000209:etiology / Q000601:surgery*