title: Association between seropositivity of antibodies against hepatitis a virus and Helicobacter pylori.
abstract: Helicobacter pylori and hepatitis A virus (HAV) are documented to share common transmission routes including fecal-oral. This study examined the association between seropositivity of antibodies against H. pylori (anti-HP) and HAV (anti-HAV) via a community-based survey of 40 randomly selected kindergartens in 10 urban and 10 rural areas. Serum samples from 2,047 healthy preschool children and 104 teachers were screened for anti-HP by enzyme-linked immunosorbent assay, and for anti-HAV by microparticle enzyme immunoassay. In children, a low prevalence of anti-HAV (0.44%) was found, in contrast to a high prevalence in their teachers (78.8%); anti-HP seroprevalence was 6.4% for children and 30.8% for teachers. Anti-HAV and anti-HP seropositivities were significantly associated in teachers after adjustment for age, sex, and residential area through multiple logistic regression analysis (multivariate-adjusted odds ratio = 7.3; 95% confidence interval [CI] = 1.4-36.8, P < 0.001). Our findings suggest that HAV and H. pylori may have shared transmission routes in central Taiwan 15 years or more ago, but not any recently.
authors.affiliation: School of Medical Technology, and Graduate Institute of Medicine, Department of Anatomy, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China.
authors.forename: D B
authors.initials: DB
authors.lastname: Lin
authors.forename: T P
authors.initials: TP
authors.lastname: Tsai
authors.forename: C C
authors.initials: CC
authors.lastname: Yang
authors.forename: H M
authors.initials: HM
authors.lastname: Wang
authors.forename: W T
authors.initials: WT
authors.lastname: Nieh
authors.forename: U P
authors.initials: UP
authors.lastname: Ling
authors.forename: S P
authors.initials: SP
authors.lastname: Changlai
authors.forename: S L
authors.initials: SL
authors.lastname: You
authors.forename: M S
authors.initials: MS
authors.lastname: Ho
authors.forename: C J
authors.initials: CJ
authors.lastname: Chen
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006506:Hepatitis A / Q000097:blood / Q000453:epidemiology*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D015994:Incidence; D008297:Male; D012423:Rural Health; D016036:Seroepidemiologic Studies; D013624:Taiwan / Q000453:epidemiology; D014504:Urban Health
chemical_list: D000907:Antibodies, Bacterial; D000914:Antibodies, Viral