title: Prevention of postoperative complications in skull base surgery for nasal or paranasal sinus carcinoma invading the skull base.
abstract: With recent technical advances in skull base surgery, radical resection of a nasal or paranasal sinus carcinoma invading the skull base can now be achieved. To assure a satisfactory surgical result, it is essential to prevent postoperative infection. In our series of 14 cases, serious postoperative infections occurred in the earliest 10 cases, and only 2 of these patients are still alive. The vascularised abdominal muscle flap for skull base reconstruction was fixed with fibrin glue, but was not adequate to fill the dead space, resulting in cerebrospinal fluid leakage and subsequent meningitis. Once the infection occurred, a free bone flap became the focus of infection. Based on these earlier experiences, we used a ROC fastener system to completely fill the dead space with an abdominal muscle flap, and bone flap was primarily craniectomised in the four most recent cases. With this technique, there were no postoperative infections.
authors.affiliation: Department of Neurosurgery, Hamamatsu University School of Medicine, Shizuoka, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nishizawa
authors.forename: N
authors.initials: N
authors.lastname: Yokota
authors.forename: T
authors.initials: T
authors.lastname: Yokoyama
authors.forename: H
authors.initials: H
authors.lastname: Mukodaka
authors.forename: T
authors.initials: T
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Hoshino
authors.forename: Y
authors.initials: Y
authors.lastname: Ueda
mesh_terms: D000009:Abdominal Muscles / Q000637:transplantation; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000601:surgery*; D002426:Cavernous Sinus / Q000473:pathology / Q000601:surgery; D003399:Craniotomy / Q000295:instrumentation / Q000379:methods*; D005005:Ethmoid Sinus / Q000473:pathology / Q000601:surgery; D005260:Female; D005626:Frontal Sinus / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000473:pathology / Q000601:surgery*; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control*; D012189:Retrospective Studies; D019291:Skull Base / Q000473:pathology / Q000601:surgery*; D013524:Surgical Flaps / Q000009:adverse effects; D013530:Surgical Wound Infection / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D016896:Treatment Outcome