title: Longitudinal study of resting energy expenditure, body cell mass and the inflammatory response in male patients with non-small cell lung cancer.
abstract: The aim of this study was to examine the inter-relationship between the inflammatory response and resting energy expenditure in patients with non-small cell lung cancer (NSCLC) before and after the onset of weight loss. Healthy subjects (n=7) and patients with NSCLC without weight loss (n=12) were studied. Resting energy expenditure adjusted for metabolically active tissue, as measured by total body potassium, was approximately 15% higher in the NSCLC group (P<0.01). Moreover, the resting energy expenditure, correlated with the magnitude of the inflammatory response (r=0.753, P<0.01). Six cancer patients subsequently lost weight and the relationship between resting energy expenditure and the inflammatory response was maintained. These results highlight the impact of the inflammatory response on the increase in the resting energy expenditure which precedes the onset of weight loss in patients with NSCLC.
authors.affiliation: Department of Respiratory Medicine, Stobhill NHS Trust, G21 3UW, Glasgow, UK.
authors.forename: H R
authors.initials: HR
authors.lastname: Scott
authors.forename: D C
authors.initials: DC
authors.lastname: McMillan
authors.forename: W S
authors.initials: WS
authors.lastname: Watson
authors.forename: R
authors.initials: R
authors.lastname: Milroy
authors.forename: C S
authors.initials: CS
authors.lastname: McArdle
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D002097:C-Reactive Protein; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications / Q000473:pathology*; D016022:Case-Control Studies; D004734:Energy Metabolism; D006801:Humans; D007249:Inflammation; D008137:Longitudinal Studies; D008175:Lung Neoplasms / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D015431:Weight Loss
chemical_list: D002097:C-Reactive Protein