Inhibitory effect of oxcarbazepine on high-frequency firing in peripheral nerve fibers.
We assessed the effects of oxcarbazepine, an antiepileptic derivative of carbamazepine, on discharges in single cutaneous afferent fibers produced by repetitive high-frequency stimulation (mimicking the abnormal excitation of peripheral nerves in neuropathic pain and paresthesia). After intravenous administration of oxcarbazepine, the later responses in the train dropped out without the earlier ones being affected and, thus, the total number of spikes decreased. The latency of the responses to an individual pulse was unchanged. These results, which indicate that oxcarbazepine inhibits the generation of high-frequency firing without affecting impulse conduction, suggest that this drug may be useful against neuropathic pain and paresthesia.
Ichikawa
K
K
Pharmacology Research R&D, Kissei Pharmaceutical Co. Ltd., 4365-1 Kashiwabara, Hotaka, Minamiazumi, 399-8304, Nagano, Japan. kiyoshi_ichikawa@pharm.kissei.co.jp
Koyama
N
N
Kiguchi
S
S
Kojima
M
M
Yokota
T
T
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002220:Carbamazepine / Q000031:analogs & derivatives / Q000494:pharmacology*; D002415:Cats; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D009412:Nerve Fibers / Q000187:drug effects* / Q000502:physiology; D000078330:Oxcarbazepine; D010525:Peripheral Nerves / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D000927:Anticonvulsants; D002220:Carbamazepine; D000078330:Oxcarbazepine