Therapeutic antibody production technologies: molecules, applications, expression and purification.
Antibody-based therapeutics are currently being tested in an increasingly diverse range of therapeutic modalities. Many different engineered formats for the antibody molecule and multiple methods for raising and tailoring binding specificities are currently available. Comparison of the relative function and efficacy of these molecules and the many competing methods for their production is crucial for making an informed selection of a new therapeutic entity. In addition, these choices may be influenced by the attached intellectual property burden.
Humphreys
D P
DP
Celitech-Chiroscience Ltd, 216 Bath Road, Slough, Berkshire SL1 4EN, UK. dhumphre@celitech.co.uk
Glover
D J
DJ
D000818:Animals; D030801:Animals, Genetically Modified; D000906:Antibodies / Q000302:isolation & purification / Q000627:therapeutic use*; D001709:Biotechnology / Q000191:economics / Q000379:methods*; D018929:Cell Culture Techniques / Q000191:economics / Q000379:methods; D006801:Humans; D030821:Plants, Genetically Modified; D015202:Protein Engineering / Q000191:economics / Q000379:methods; D011994:Recombinant Proteins / Q000096:biosynthesis* / Q000627:therapeutic use*; D013678:Technology, Pharmaceutical / Q000191:economics / Q000379:methods*
D000906:Antibodies; D011994:Recombinant Proteins