title: Pharmacokinetic behaviour of phenylglyoxal bis(guanylhydrazone) (PGBG) after intravenous administration in rabbits.
abstract: Phenylglyoxal bis(guanylhydrazone) (PGBG) is a synthesized analogue of methylglyoxal bis(guanylhydrazone) (MGBG), which has demonstrated anti-parasitic activity in rabbits. The pharmacokinetic behaviour of PGBG after intravenous administration (10 mg/kg bodyweight) was studied in five rabbits. Plasma concentrations of PGBG were measured by high-performance liquid chromatography. Plasma PGBG concentrations decreased rapidly and were not detectable beyond 90 min after treatment. The mean [+/- standard deviation (SD)] volume of distribution at steady state (Vdss) was 2.19 +/- 0.47 l/kg and the mean plasma clearance value (Cl) was 29.99 +/- 3.98 ml/min kg. This drug is rapidly eliminated from the body in rabbits, having a short elimination half-life (0.93 h) and mean residence time (1.21 h).
authors.affiliation: Cátedra de Farmacología, Departamento de Toxicología y Farmacología, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda/Puerta de Hierro s/n, 28040 Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez
authors.forename: M I
authors.initials: MI
authors.lastname: San Andrés
authors.forename: M D
authors.initials: MD
authors.lastname: San Andrés
authors.forename: T
authors.initials: T
authors.lastname: Encinas
authors.forename: F
authors.initials: F
authors.lastname: González
authors.forename: E
authors.initials: E
authors.lastname: Ballesteros
mesh_terms: D000818:Animals; D000977:Antiparasitic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004791:Enzyme Inhibitors / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006207:Half-Life; D007275:Injections, Intravenous / Q000662:veterinary; D008657:Metabolic Clearance Rate; D008935:Mitoguazone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D011817:Rabbits / Q000378:metabolism*
chemical_list: D000977:Antiparasitic Agents; D004791:Enzyme Inhibitors; C048255:propylglyoxal bis(guanylhydrazone); D008935:Mitoguazone