Pseudo-C(3)-symmetric tertiary alcohol building block via group-selective hydroalumination: a synthesis of (-)-malyngolide.
The stereocontrolled preparation of tertiary alcohol 4 and its TMS surrogate 5, which share a pseudo-C(3)()-symmetry, is described. Compound 4 was used for the synthesis of (-)-malyngolide.
Suzuki
T
T
Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8551, Japan.
Ohmori
K
K
Suzuki
K
K
D000438:Alcohols / Q000737:chemistry; D000535:Aluminum / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D011753:Pyrones / Q000138:chemical synthesis*
D000438:Alcohols; D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D011753:Pyrones; C065487:malyngolide; D000535:Aluminum