Novel procaspase-3 activating cascade mediated by lysoapoptases and its biological significances in apoptosis.
Katunuma
N
N
Institute for Health Sciences, Tokushima Bunri University, Yamashiro-cho, 770-8514, Tokushima, Japan.
Matsui
A
A
Le
Q T
QT
Utsumi
K
K
Salvesen
G
G
Ohashi
A
A
D000818:Animals; D017209:Apoptosis; D002118:Calcium / Q000378:metabolism; D006528:Carcinoma, Hepatocellular; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism*; D020134:Catalytic Domain; D002403:Cathepsins / Q000037:antagonists & inhibitors; D002462:Cell Membrane / Q000378:metabolism; D002852:Chromatography, Ion Exchange; D003593:Cytoplasm / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004591:Electrophoresis, Polyacrylamide Gel; D010450:Endopeptidases / Q000737:chemistry* / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004792:Enzyme Precursors / Q000378:metabolism*; D004852:Epoxy Compounds / Q000494:pharmacology; D005688:Galactosamine / Q000378:metabolism / Q000494:pharmacology; D006801:Humans; D008113:Liver Neoplasms / Q000378:metabolism; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008954:Models, Biological; D011725:Pyridines / Q000494:pharmacology; D051381:Rats; D011994:Recombinant Proteins / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution; D014407:Tumor Cells, Cultured
C402823:CLIK 148; D004791:Enzyme Inhibitors; D004792:Enzyme Precursors; D004852:Epoxy Compounds; D011725:Pyridines; D011994:Recombinant Proteins; D005688:Galactosamine; D002403:Cathepsins; D010450:Endopeptidases; C505407:CASP3 protein, human; C505409:Casp3 protein, mouse; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases; C430853:lysoapoptase H-Lyso; C430854:lysoapoptase L-Lyso; D002118:Calcium