title: Evolution of functionality in lattice proteins.
abstract: We study the evolution of protein functionality using a two-dimensional lattice model. The characteristics particular to evolution, such as population dynamics and early evolutionary trajectories, have a large effect on the distribution of observed structures. Only subtle differences are observed between the distribution of structures evolved for function and those evolved for their ability to form compact structures.
authors.affiliation: Department of Chemistry, University of Michigan, Ann Arbor, MI 48109-1055, USA.
authors.forename: P D
authors.initials: PD
authors.lastname: Williams
authors.forename: D D
authors.initials: DD
authors.lastname: Pollock
authors.forename: R A
authors.initials: RA
authors.lastname: Goldstein
mesh_terms: D019143:Evolution, Molecular; D008024:Ligands; D008433:Mathematics; D011485:Protein Binding; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D008024:Ligands; D011506:Proteins