title: Orbital solitary fibrous tumor: radiographic and histopathologic correlations.
abstract: OBJECTIVE
  To correlate the clinicopathologic and radiographic features characteristic of orbital solitary fibrous tumor (SFT).
  
  
  METHODS
  The diagnostic features and clinical outcome of seven adults with orbital SFT are retrospectively outlined. Orbital imaging was performed by ultrasonography, computed tomography, or magnetic resonance imaging. Some cases were imaged by multiple modalities. Histopathologic examination of each tumor specimen included standard light and immunohistochemical stains.
  
  
  RESULTS
  Heterogeneous internal composition was better appreciated on magnetic resonance imaging than on computed tomography. All cases undergoing magnetic resonance imaging showed T1 isointensity and T2 hypointensity relative to gray matter. Strong, generalized immunohistochemical reactivity to vimentin and CD34 validated the diagnosis of SFT and differentiated the specimens from other spindle cell neoplasms. After complete tumor resection, our patients remain tumor free with postoperative intervals of 15 to 45 months.
  
  
  CONCLUSIONS
  Solitary fibrous tumor has now been reported in 26 orbits. No physical finding is pathognomonic, but several imaging traits are highly characteristic. Intralesional image heterogeneity and a predominantly low T2 signal intensity are distinctive of SFT. Complete tumor resection and immunohistologic specimen evaluation are emphasized. Clinicians should consider the diagnosis of SFT when confronted with an adult patient having an orbital soft tissue mass demonstrating the distinctive magnetic resonance imaging findings.
authors.affiliation: Department of Ophthalmology, University of Missouri-Columbia, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Gigantelli
authors.forename: M C
authors.initials: MC
authors.lastname: Kincaid
authors.forename: C N
authors.initials: CN
authors.lastname: Soparkar
authors.forename: A G
authors.initials: AG
authors.lastname: Lee
authors.forename: S R
authors.initials: SR
authors.lastname: Carter
authors.forename: R P
authors.initials: RP
authors.lastname: Yeatts
authors.forename: D E
authors.initials: DE
authors.lastname: Holck
authors.forename: M E
authors.initials: ME
authors.lastname: Hartstein
authors.forename: J S
authors.initials: JS
authors.lastname: Kennerdell
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005350:Fibroma / Q000000981:diagnostic imaging* / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009918:Orbital Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed; D014463:Ultrasonography