Interleukin-1 receptor antagonist gene polymorphism and circulating levels of human immunodeficiency virus type 1 RNA in Brazilian women.
Interleukin-1 receptor antagonist (IL-1ra) gene polymorphisms in 83 human immunodeficiency virus (HIV)-seropositive women were evaluated. Fourteen of the subjects (16.9%) were homozygous for IL-1ra allele 2 (IL-1RN*2). These women had a lower median level of HIV RNA than did women homozygous for allele 1 (IL-1RN*1) (P = 0.01) or heterozygous for both alleles (P = 0.04). Among 46 subjects not receiving antiretroviral treatment, HIV levels were also reduced in IL-1RN*2 homozygous individuals (P < 0.05). There was no relation between IL-1ra alleles and CD4 levels.
Witkin
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SS
Division of Immunology and Infectious Diseases, Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, NY 10021, USA. switkin@mail.med.cornell.edu
Linhares
I M
IM
Gerber
S
S
Caetano
M E
ME
Segurado
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AC
D005260:Female; D005838:Genotype; D006679:HIV Seropositivity / Q000235:genetics* / Q000821:virology; D015497:HIV-1 / Q000302:isolation & purification*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D011110:Polymorphism, Genetic; D012367:RNA, Viral / Q000097:blood*; D012795:Sialoglycoproteins / Q000235:genetics*
C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D012367:RNA, Viral; D012795:Sialoglycoproteins