Effects of transforming growth factor-beta(1)on proliferation of smooth muscle cells in human aortic intima and human promonocytic leukemia THP-1 cells.
We studied the effects of transforming growth factor on proliferation of cultured smooth muscle cells from human aortic intima and proliferation and differentiation of human leukemia THP-1 promonocytes. Transforming growth factor inhibited proliferation of these cells, but stimulated differentiation of THP-1 cells. Therefore, transforming growth factor probably modulates proliferation and differentiation of smooth muscle cells and monocytes/macrophages involved in the pathogenesis of atherosclerotic damages.
Kalinina
N I
NI
Institute of Experimental Cardiology, Russian Research-and-Production Center for Cardiology, Russian Ministry of Health, Moscow, Russia. cardiocell@cardio.ru
Ilyinskaya
O P
OP
Bobik
A
A
Tararak
E M
EM
D001011:Aorta; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects* / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D007951:Leukemia, Myeloid; D009000:Monocytes / Q000166:cytology / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects*; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D053773:Transforming Growth Factor beta1; D014407:Tumor Cells, Cultured; D017539:Tunica Intima / Q000166:cytology / Q000187:drug effects
C508960:TGFB1 protein, human; D016212:Transforming Growth Factor beta; D053773:Transforming Growth Factor beta1