title: Recombinant human erythropoietin in the treatment of head and neck tumour anaemia.
abstract: At the time of first diagnosis, patients with squamous cell carcinoma in the head and neck are often in the advanced stage of their disease, therefore surgery is not a viable option for treatment. These patients also present frequently a high grade of anaemia as a result of either the malignant process itself or of the following therapy. The incidence of anaemia and the need for transfusion depends on several factors, such as the type and intensity of radiotherapy and radiochemotherapy. Multimode therapeutic concepts such as radio-chemotherapy are being applied with increasing frequency, resulting in an ever increasing need for transfusion with great effects on the patient's quality of life. Even more important to tumour patients is the role of the haemaglobin (Hb) value as a prognostic factor for survival and/or local tumour control. A large number of studies show that recombinant human erythropoietin (r-HuEPO) is effective in the treatment of tumour-induced anaemia and prevention and correction of chemotherapy and radiotherapy-induced anaemia. The simultaneous application of r-HuEPO with chemotherapy can prevent patients with head and neck tumours from developing anaemia or can reduce the extent of the anaemia and the need for transfusion. Comparable effects were observed both in patients undergoing platinum-based and non-platinum-based chemotherapy. The direct correlation between anaemia, tumour hypoxia and poor response to radio and/or chemotherapy has been clinically proven. Recombinant human erythropoietin administration improves the therapeutic outcome and the patients' prognosis.
authors.affiliation: Charité Campus Virchow-Klinikum, Medical Faculty of the Humboldt University in Berlin/Germany. helmut.oettle@charite.de
authors.forename: H
authors.initials: H
authors.lastname: Oettle
authors.forename: H
authors.initials: H
authors.lastname: Riess
authors.forename: J D
authors.initials: JD
authors.lastname: Raguse
authors.forename: J
authors.initials: J
authors.lastname: Bier
authors.forename: H J
authors.initials: HJ
authors.lastname: Gath
mesh_terms: D000740:Anemia / Q000517:prevention & control*; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D006258:Head and Neck Neoplasms / Q000628:therapy*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D020360:Neoadjuvant Therapy; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009367:Neoplasm Staging; D011379:Prognosis; D011788:Quality of Life; D011994:Recombinant Proteins; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin