title: Decreased susceptibility to ciprofloxacin in Salmonella enterica serotype typhi, United Kingdom.
abstract: In 1999, 23% of Salmonella enterica serotype Typhi isolates from patients in the United Kingdom exhibited decreased susceptibility to ciprofloxacin (MIC 0.25-1.0 mg/L); more than half were also resistant to chloramphenicol, ampicillin, and trimethoprim. Increasing numbers of treatment failures have been noted. Most infections have been in patients with a recent history of travel to India and Pakistan.
authors.affiliation: Central Public Health Laboratory, London, United Kingdom. jthrelfall@phls.nhs.uk
authors.forename: E J
authors.initials: EJ
authors.lastname: Threlfall
authors.forename: L R
authors.initials: LR
authors.lastname: Ward
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D006801:Humans; D008826:Microbial Sensitivity Tests; D012485:Salmonella typhi / Q000187:drug effects*
chemical_list: D000890:Anti-Infective Agents; D002939:Ciprofloxacin