title: Automated responsiveness test (ART) predicts loss of consciousness and adverse physiologic responses during propofol conscious sedation.
abstract: BACKGROUND
  The authors evaluated a device designed to provide conscious sedation with propofol (propofol-air), or propofol combined with 50% nitrous oxide (N2O; propofol-N2O). An element of this device is the automated responsiveness test (ART), a method for confirming that patients remain conscious. The authors tested the hypotheses that the ART predicts loss of consciousness and that failure to respond to the ART precedes sedation-induced respiratory or hemodynamic toxicity.
  
  
  METHODS
  The protocol consisted of sequential 15-min cycles in 20 volunteers. After a 15-min control period, propofol was infused to an initial target effect-site concentration of 0.0 microg/ml with N2O or 1.5 microg/ml with air. Subsequently, the propofol target effect-site concentration was increased by a designated increment (0.25 and 0.5 microg/ml) and the process repeated. This sequence was continued until loss of consciousness, as defined by an Observer's Assessment of Alertness/Sedation (OAA/S) score of 10/20 or less, or until an adverse physiologic event was detected.
  
  
  RESULTS
  The OAA/S score at which only 50% of the volunteers were able to respond to the ART (P50) during propofol-N2O was 11.1 of 20 (95% confidence interval [CI]: 10.6-11.8); the analogous P50 was 11.8 of 20 (95% CI: 11.4-12.3) with propofol-air. Failure to respond to the ART occurred at a plasma propofol concentration of 0.7 +/- 0.6 microg/ml with propofol-N2O and 1.6 +/- 0.6 microg/ml with propofol-air, whereas loss of consciousness occurred at 1.2 +/- 0.8 microg/ml and 1.9 +/- 0.7 microg/ml, respectively. There were no false-normal ART responses.
  
  
  CONCLUSIONS
  The ART can guide individual titration of propofol because failure to respond to responsiveness testing precedes loss of consciousness and is not susceptible to false-normal responses. The use of N2O with propofol for conscious sedation decreases the predictive accuracy of the ART.
authors.affiliation: Department of Anesthesia and Perioperative Care, University of California-San Francisco, USA.
authors.forename: A G
authors.initials: AG
authors.lastname: Doufas
authors.forename: M
authors.initials: M
authors.lastname: Bakhshandeh
authors.forename: A R
authors.initials: AR
authors.lastname: Bjorksten
authors.forename: R
authors.initials: R
authors.lastname: Greif
authors.forename: D I
authors.initials: DI
authors.lastname: Sessler
mesh_terms: D000328:Adult; D016292:Procedural Sedation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D011336:Probability; D015742:Propofol / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D014474:Unconsciousness
chemical_list: D006993:Hypnotics and Sedatives; D015742:Propofol