A long-term lifetime amperometric glucose sensor with a perfluorocarbon polymer coating.
We have developed an amperometric glucose sensor whose electrodes are coated with a four-layered membrane: 3-aminopropyltriethoxysilane (gamma-APTES), Nafion, glucose oxidase (GOX), and perfluorocarbon polymer (PFCP). Tests demonstrate the sensor's ability to accurately and successively determine glucose concentrations ranging from 2.8 to 167 mM, over a 66 day period with no increase in response time, while remaining imperviousness to the effects of interference species (2.8 mM ascorbic acid, 0.3 mM uric acid, 0.3 mM p-acetaminophen). Furthermore, tests on diabetic urine samples showed an excellent correlation coefficient of 0.985 (y=1.04x+4.73, n=30) between sensor results and those of Glucose-Dehydrogenase clinical laboratory analyses.
Matsumoto
T
T
NEC Corporation, 4-1-1 Miyazaki Miyamae-ku, Kawasaki, Kanagawa 216-8555, Japan. matsu@rel.cl.nec.co.jp
Ohashi
A
A
Ito
N
N
Fujiwara
H
H
Matsumoto
T
T
D015374:Biosensing Techniques; D005466:Fluorocarbons; D005947:Glucose / Q000032:analysis*; D011108:Polymers; D013997:Time Factors
D005466:Fluorocarbons; D011108:Polymers; D005947:Glucose