Coordinate regulation of metabotropic glutamate receptors.
Recent studies aimed at identifying the mechanisms that regulate the signaling of metabotropic glutamate receptors (mGluRs) have revealed that both protein kinase and protein phosphatase activity are important in directly modulating mGluR function. The inter-relationship between phosphorylation and dephosphorylation of mGluRs seems to be an important determinant in regulating mGluR function and the subsequent neuromodulatory events elicited by activation of mGluRs.
Alagarsamy
S
S
1510 Clifton Road, Rollins Research Center Room 5160, Department of Pharmacology, Emory University, Atlanta, GA 30322, USA. salagar@emory.edu
Sorensen
S D
SD
Conn
P J
PJ
D000818:Animals; D001921:Brain / Q000166:cytology / Q000502:physiology; D002478:Cells, Cultured; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D018698:Glutamic Acid / Q000502:physiology*; D006801:Humans; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000502:physiology*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D021122:Protein Subunits; D020239:Receptor Cross-Talk / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D017661:Receptors, Presynaptic / Q000502:physiology; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*
D009419:Nerve Tissue Proteins; D021122:Protein Subunits; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D017661:Receptors, Presynaptic; D018698:Glutamic Acid; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C