Combined histologic and molecular features reveal previously unappreciated subsets of lymphoma in AKXD recombinant inbred mice.
Hematopoietic neoplasms developing in AKXD recombinant inbred, NFS.V(+) and ICSBP knockout mice were assessed using morphologic, cytologic and molecular criteria that relate these disorders to human lymphoma and leukemia. Lymphoma types included precursor T-cell and B-cell lymphoblastic, small lymphocytic, splenic marginal zone, follicular, and diffuse large cell (DLCL). In addition to previously defined subtypes of DLCL composed of centroblasts or immunoblasts, two additional subtypes are defined here: lymphoblastic lymphoma like (LL) and lymphoma characterized by a histiocytic reaction (HS). DLCL(HS) were distinguished from true histiocytic lymphomas by the presence of clonal Ig gene rearrangements.
Morse
H C
HC
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Room 7/304, 7 Center Drive, Bethesda, MD 20892-0760, USA.
Qi
C F
CF
Chattopadhyay
S K
SK
Hori
M
M
Taddesse-Heath
L
L
Ozato
K
K
Hartley
J W
JW
Taylor
B A
BA
Ward
J M
JM
Jenkins
N A
NA
Copeland
N G
NG
Fredrickson
T N
TN
D000818:Animals; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D005260:Female; D015321:Gene Rearrangement; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor / Q000235:genetics; D019674:Genes, T-Cell Receptor beta / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification / Q000235:genetics / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000145:classification / Q000235:genetics / Q000473:pathology*; D051379:Mice; D008806:Mice, Inbred AKR; D008811:Mice, Inbred DBA; D018345:Mice, Knockout; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000145:classification / Q000235:genetics / Q000473:pathology
D007143:Immunoglobulin Heavy Chains; D007145:Immunoglobulin kappa-Chains