title: Improved in vitro quantification of the force exerted by the papillary muscle on the left ventricular wall: three-dimensional force vector measurement system.
abstract: Recent developments indicate that the forces acting on the papillary muscles can be a measure of the severity of mitral valve regurgitation. Pathological conditions, such as ischemic heart disease, cause changes in the geometry of the left ventricle and the mitral valve annulus, often resulting in displacement of the papillary muscles relative to the annulus. This can lead to increased tension in the chordae tendineae. This increased tension is transferred to the leaflets, and can disturb the coaptation pattern of the mitral valve. The force balance on the individual components governs the function of the mitral valve. The ability to measure changes in the force distribution from normal to pathological conditions may give insight into the mechanisms of mitral valve insufficiency. A unique in vitro model has been developed that allows quantification of the papillary muscle spatial position and quantification of the three-dimensional force vector applied to the left ventricular wall by the papillary muscles. This system allows for the quantification of the global force exerted on the posterior left ventricular wall from the papillary muscles during simulation of normal and diseased conditions.
authors.affiliation: Georgia Institute of Technology/Emory School of Biomedical Engineering, Atlanta 30332-0535, USA.
authors.forename: M O
authors.initials: MO
authors.lastname: Jensen
authors.forename: A A
authors.initials: AA
authors.lastname: Fontaine
authors.forename: A P
authors.initials: AP
authors.lastname: Yoganathan
mesh_terms: D000818:Animals; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering; D066298:In Vitro Techniques; D008943:Mitral Valve / Q000502:physiology; D008944:Mitral Valve Insufficiency / Q000503:physiopathology; D008955:Models, Cardiovascular; D010210:Papillary Muscles / Q000502:physiology*; D013552:Swine; D016276:Ventricular Function; D016277:Ventricular Function, Left / Q000502:physiology*