title: Prevention of meningococcal serogroup B infections in children: a protein-based vaccine induces immunologic memory.
abstract: Immunologic memory against meningococci was studied in 177 children (100 children were 10-11 years old and 77 were 5-6 years old) 2.5 years after vaccination with hexavalent meningococcal outer membrane vesicle (OMV) vaccine or hepatitis B (HepB) vaccine. Children were revaccinated with monovalent P1.7(h),4 meningococcal OMV vaccine. Serum bactericidal antibodies (SBAs) were measured before revaccination and after 4-6 weeks. A minimum 4-fold increase in SBAs against serosubtype P1.7(h),4 was detected in 48.5% of the children after hexavalent meningococcal vaccine and in 8.9% after HepB vaccine. Of the initial responders given hexavalent meningococcal vaccine, 78% had > or =4-fold increase in SBAs against strain P1.4. Thus, immunologic memory is present in toddlers and school-aged children previously given 3 hexavalent meningococcal vaccinations. Booster vaccination with monovalent P1.7(h),4 meningococcal OMV vaccine induces a significant increase in SBAs against serosubtype P1.7(h),4 and cross-reactivity against other serosubtypes in the hexavalent vaccine.
authors.affiliation: Department of Pediatrics, University Hospital Rotterdam and Sophia Children's Hospital, Rotterdam, The Netherlands.
authors.forename: E D
authors.initials: ED
authors.lastname: de Kleijn
authors.forename: R
authors.initials: R
authors.lastname: de Groot
authors.forename: A B
authors.initials: AB
authors.lastname: Lafeber
authors.forename: J
authors.initials: J
authors.lastname: Labadie
authors.forename: C J
authors.initials: CJ
authors.lastname: van Limpt
authors.forename: J
authors.initials: J
authors.lastname: Visser
authors.forename: G A
authors.initials: GA
authors.lastname: Berbers
authors.forename: L
authors.initials: L
authors.lastname: van Alphen
authors.forename: H C
authors.initials: HC
authors.lastname: Rümke
mesh_terms: D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D017325:Hepatitis B Vaccines / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary; D007156:Immunologic Memory / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008585:Meningitis, Meningococcal / Q000517:prevention & control*; D022401:Meningococcal Vaccines / Q000276:immunology*; D009345:Neisseria meningitidis
chemical_list: D000907:Antibodies, Bacterial; D017325:Hepatitis B Vaccines; D022401:Meningococcal Vaccines