title: Effect of nifedipine in metastatic colon cancer with DNA mismatch repair gene defect.
abstract: Cancer cells that have DNA mismatch repair deficiency are resistant to many cytotoxic drugs. Calcium channel blockers may inhibit the pathways that cause such resistance. We report a patient with hereditary non-polyposis coli and metastatic colon cancer who had a complete response after treatment with a high dose of nifedipine, a calcium channel blocker. Our findings suggest that drugs that interfere with signal transduction could have a clinical role and deserve further study in selected patients.
authors.forename: J L
authors.initials: JL
authors.lastname: Yang
authors.forename: M L
authors.initials: ML
authors.lastname: Friedlander
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D011125:Adenomatous Polyposis Coli / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary*; D004260:DNA Repair / Q000187:drug effects / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D013274:Stomach Neoplasms / Q000473:pathology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D009543:Nifedipine