Pituitary adenylate cyclase activating polypeptide is highly abundant in the nervous system of anoxia-tolerant turtle, Pseudemys scripta elegans.
The levels of the pituitary adenylate cyclase activating polypeptide (PACAP) were measured in the central nervous system and in peripheral organs of the anoxia-tolerant freshwater turtle, Pseudemys scripta elegans by radioimmunoassay. The concentration of PACAP38 was strikingly high in the central nervous system and lower but considerable immunoreactivity was detected in the peripheral organs. Levels of PACAP38 in the turtle brain exceed those measured in rat and human brain areas by 10-100-fold. Based on these exceptionally high levels of PACAP and the known neuroprotective role of the peptide, it can be suggested that PACAP38 plays a role in the extraordinary resistance of the turtle brain from anoxia-induced neuronal damage.
Reglödi
D
D
Department of Anatomy, University of Pécs, Hungary.
Somogyvári-Vigh
A
A
Vígh
J
J
Li
M
M
Lengvári
I
I
Arimura
A
A
D000818:Animals; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000378:metabolism; D008297:Male; D009479:Neuropeptides / Q000096:biosynthesis* / Q000737:chemistry*; D018377:Neurotransmitter Agents / Q000096:biosynthesis / Q000737:chemistry; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011863:Radioimmunoassay; D051381:Rats; D014018:Tissue Distribution; D014426:Turtles
C495401:ADCYAP1 protein, human; C495403:Adcyap1 protein, rat; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide