[Morphofunctional analysis of right ventricle cardiomyocytes in patients with Fallot's tetrad during first year of life].
Material of intrasurgical biopsies of the right ventricular (RV) myocardium of 28 patients with Fallot's tetrad was studied with light and electron microscopy. RV cardiomyocytes were hypertrophic and showed signs of growth and differentiation. Myofibrillogenesis intensity directly correlated with the pressure gradient between RV and pulmonary artery. At the same time there was a structural alteration of mitochondria and formation of a specialized population of intermyofibrillar mitochondria. Continuing myofibrillogenesis in cardiomyocytes may be one of the causes of decreased myocardial contractility.
Egorova
I F
IF
A. N. Bakulev Research Center of Cardiovascular Surgery, 121522, Moscow.
Serov
R A
RA
Il'in
V N
VN
Sharykin
A S
AS
D006352:Heart Ventricles / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008854:Microscopy, Electron; D013771:Tetralogy of Fallot / Q000473:pathology* / Q000601:surgery