[GB virus-C infection in Chinese patients with hepatocellular carcinoma].
Hepatitis B and C viruses (HBV, HCV) are closely related with hepatocellular carcinoma(HCC). The association between the new discovered GB-virus C (GBV-C) and HCC has not yet been known. In this study, 124 HCC patients were detected for the prevalence of GBV-C RNA by the one-step nested reverse transcription polymerase chain reaction (RT-PCR) and followed by hybridization using GBV-C probes located at 3'-untranslated region (3'-UTR) from its reported genomes. The results showed that 33 of 124 (26.6%) HCC cases were GBV-C RNA positive, including 12 cases positive HBsAg and anti-HCV, and 3 for cases negative HBsAg and anti-HCV. The clinical background of the patients with HBsAg and/or anti-HCV who were also positive for GBV-C RNA did not differ from the background of those who were negative for GBV-C RNA except the ratio of blood transfusion history. In conclusion, GBV-C has a high prevalence in Chinese HCC patients. Even though no sufficient data supports the causality of GBV-C on hepatocarcinogenesis, further researches aimed at whether GBV-C infection aggravates the incidence of HCC are warranted.
Lei
X
X
Department of Infectious Diseases, First Affiliated Hospital, WCUMS, Chengdu 610041.
Yoshihiro
A
A
Liu
L
L
Zhao
L
L
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000821:virology*; D005260:Female; D018178:Flaviviridae Infections; D029407:GB virus C / Q000276:immunology / Q000302:isolation & purification; D006525:Hepatitis, Viral, Human / Q000150:complications; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood
D012367:RNA, Viral