The effect of acenocoumarol on hemorheological parameters.
The effect of acenocoumarol on hemorheological variables was measured in 35 non-valvular chronic atrial fibrillation patients before starting oral anticoagulant therapy (basal) and one and two months after beginning treatment (INR-2,3). Fibrinogen increased significantly from the basal situation: 332+/-99 mg/dl to 386+/-96 mg/dl in the second month (p<0.05). However, this small increase in fibrinogen is not large enough to mediate other rheological changes, and whole blood filterability, blood viscosity, plasma viscosity and erythrocyte deformability and aggregability remained unchanged after treatment. These results suggest that acenocoumarol does not affect rheological parameters and can therefore be used as a "neutral drug" for rheological studies in cardiovascular patients under oral anticoagulant therapy.
Vayá
A
A
Hemorheology and Thrombosis Unit, Department of Clinical Pathology, La Fe University Hospital, Valencia, Spain. vaya_amp@gva.es
Martínez
M
M
Fernández
A
A
Ripoll
F
F
Moscardó
F
F
Mira
Y
Y
Aznar
J
J
D000074:Acenocoumarol / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000284:Administration, Oral; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000097:blood / Q000188:drug therapy*; D001809:Blood Viscosity / Q000187:drug effects; D004341:Drug Evaluation; D004909:Erythrocyte Indices / Q000187:drug effects; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D018056:Hemorheology / Q000187:drug effects*; D006801:Humans; D019934:International Normalized Ratio; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012449:Safety
D000925:Anticoagulants; D005340:Fibrinogen; D000074:Acenocoumarol