title: Short-term orlistat treatment does not affect mineral balance and bone turnover in obese men.
abstract: Orlistat is a gastrointestinal lipase inhibitor that is used to reduce dietary fat absorption and to enhance weight loss in subjects consuming a hypocaloric diet. To assess whether orlistat has an effect on the metabolism of six minerals, a 21-d, double-blind, randomized, parallel-group, placebo-controlled mineral balance study was conducted in obese (body mass index > 30 kg/m(2)) men. Subjects consumed a hypocaloric diet with a constant daily mineral content and received daily oral treatment with orlistat (120 mg three times daily) (n = 14) or placebo (three times daily) (n = 14) for 21 d. After a 14-d equilibration period, calcium, phosphorus, magnesium, iron, copper and zinc balances were assessed for d 15-21. In addition, the effect of diet and orlistat treatment on bone metabolism was estimated from measurement of biomarkers of bone formation and bone resorption. Serum and urine electrolytes were also measured at baseline and at the end of treatment. Orlistat inhibited fat absorption by approximately 33% (P < 0.05). There were no significant differences in mineral apparent absorption, urinary mineral loss or mineral balance between the orlistat and placebo groups. Markers of bone turnover and serum and urine electrolytes did not differ between the orlistat and placebo groups. Orlistat was well tolerated; adverse events were of mild or moderate intensity, and the majority of these events were unrelated or remotely related to study treatment. In obese men consuming a hypocaloric diet, the administration of orlistat had no significant effect on the balance of six selected minerals. In addition, biomarkers of bone turnover, as well as serum and urine electrolytes, were not affected by orlistat treatment.
authors.affiliation: Roche Laboratories Inc., Nutley, New Jersey, USA. Daniel.Pace@Roche.com
authors.forename: D G
authors.initials: DG
authors.lastname: Pace
authors.forename: S
authors.initials: S
authors.lastname: Blotner
authors.forename: R
authors.initials: R
authors.lastname: Guerciolini
mesh_terms: D000328:Adult; D019440:Anti-Obesity Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001842:Bone and Bones / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage / Q000032:analysis; D004311:Double-Blind Method; D004573:Electrolytes / Q000097:blood / Q000652:urine; D002149:Energy Intake; D004791:Enzyme Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D005243:Feces / Q000737:chemistry; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007783:Lactones / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008903:Minerals / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D009765:Obesity / Q000188:drug therapy / Q000378:metabolism* / Q000652:urine; D000077403:Orlistat
chemical_list: D019440:Anti-Obesity Agents; D004041:Dietary Fats; D004573:Electrolytes; D004791:Enzyme Inhibitors; D007783:Lactones; D008903:Minerals; D000077403:Orlistat