Contrast agents in acute myocardial infarction.
The experimental design in examination of acute myocardial infarctions should be valid in terms of flow, perfusion and re-flow after intervention. The contrast agents concentration in experimental studies can be measured by microdialysis. We have assessed the usefulness of different extracellular and blood pool contrast agents for visualization of the area at risk in coronary artery occlusions. The double contrast technique, where Dy-DTPA-BMA was combined with Gd-DTPA-BMA yielded a superior infarct visualization. Blood pool agents for example NC100/150 injection is also promising in first path myocardial perfusion imaging.
Hemmingsson
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A
Department of Oncology, Radiology and Clinical Immunology, Section of Radiology, University Hospital, SE-751 85 Uppsala, Sweden. anders.hemmingsson@radiol.uu.se
Bjerner
T
T
Ericsson
A
A
Johansson
L
L
Ahlström
H
H
D003287:Contrast Media; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D019786:Gadolinium DTPA; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000503:physiopathology*; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives
D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004369:Pentetic Acid; C064925:gadodiamide; D019786:Gadolinium DTPA