title: Linkage of otopalatodigital syndrome type 2 (OPD2) to distal Xq28: evidence for allelism with OPD1.
abstract: Otopalatodigital syndrome type 1 (OPD1) is an X-linked semidominant condition characterized by malformations of the skeleton, auditory apparatus, and palate. Previous studies have established linkage to a 16-cM region of Xq27-q28. A proposed allelic variant of OPD1, termed "OPD2," is associated with a more severe, frequently lethal phenotype with visceral and brain anomalies in addition to skeletal, auditory, and palatal defects. We report linkage of the OPD2 phenotype to a 2-cM region of distal Xq28 in a Maori kindred, with a maximum multipoint LOD score of 3.31 between the markers DXS1073 and DXS1108. This provides support for allelism between OPD1 and OPD2 and reduces the size of the disease interval to 1.8-2.1 Mb. We also demonstrate that female carriers of this disorder exhibit skewed inactivation that segregates with the high-risk haplotype and may be inversely related to the severity with which they manifest features of the disorder.
authors.affiliation: Weatherall Institute of Molecular Medicine, The John Radcliffe Hospital, Headington, Oxford OX3 9DS, United Kingdom.
authors.forename: S P
authors.initials: SP
authors.lastname: Robertson
authors.forename: S
authors.initials: S
authors.lastname: Walsh
authors.forename: M
authors.initials: M
authors.lastname: Oldridge
authors.forename: T
authors.initials: T
authors.lastname: Gunn
authors.forename: D
authors.initials: D
authors.lastname: Becroft
authors.forename: A O
authors.initials: AO
authors.lastname: Wilkie
mesh_terms: D000015:Abnormalities, Multiple / Q000235:genetics* / Q000401:mortality; D000483:Alleles; D001921:Brain / Q000002:abnormalities; D002874:Chromosome Mapping; D020090:Chromosome Segregation / Q000235:genetics; D019465:Craniofacial Abnormalities / Q000235:genetics* / Q000401:mortality; D004303:Dosage Compensation, Genetic; D005260:Female; D008040:Genetic Linkage / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics; D006239:Haplotypes / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008126:Lod Score; D008297:Male; D009154:Mutation / Q000235:genetics; D010159:Palate / Q000002:abnormalities*; D010375:Pedigree; D010641:Phenotype; D011995:Recombination, Genetic / Q000235:genetics; D013577:Syndrome; D014960:X Chromosome / Q000235:genetics*