title: Statistical comparisons of the no-observed-effect concentration and the effective concentration at 10% inhibition (EC10) in algal toxicity tests.
abstract: Batch-type algal toxicity tests were conducted to evaluate the low toxic effects of metal toxicants. Both the no-observed-effect concentration (NOEC) and the effective concentration at 10% inhibition (EC10) were calculated and compared. The results of this study indicate that, for algal toxicity tests, NOEC offers better protection to the test organisms than EC10. In addition, the consistency of NOEC is found to depend on the response endpoints measured. A cut-off-value approach is proposed to determine whether NOEC or EC10 should be chosen for estimating low toxic effects. For a specific toxicity test, the average cut-off value directly indicates the magnitude of the square root of the within-group-variance. A precise test associated with small within-group-variances also produces relatively small average cut-off value (say, less than 10% of the growth reduction). This average value provides useful information on the minimum protection that can be offered by the NOEC.
authors.affiliation: Institute of Environmental Engineering, National Chiao Tung University 75, Po-Ai Street, Hisnchu, Taiwan 300.
authors.forename: J N
authors.initials: JN
authors.lastname: Shieh
authors.forename: M R
authors.initials: MR
authors.lastname: Chao
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
mesh_terms: D004305:Dose-Response Relationship, Drug; D004785:Environmental Pollutants / Q000633:toxicity*; D056890:Eukaryota / Q000187:drug effects* / Q000502:physiology; D019055:No-Observed-Adverse-Effect Level; D012016:Reference Values
chemical_list: D004785:Environmental Pollutants