Ca(2+)-Activated Cl(-) Channels: A Newly Emerging Anion Transport Family.
A new family of Cl(-) channels widely expressed in epithelia has been identified. These proteins are associated with Ca(2+)-sensitive conductive Cl(-) transport when heterologously expressed. This family may underlie the Ca(2+)-mediated Cl(-) conductance responsible for rescue of the cystic fibrosis knockout mouse from significant airway disease.
Fuller
Catherine M.
CM
Department of Physiology and Biophysics, University of Alabama at Birmingham, Birmingham, Alabama 35294.
Benos
Dale J.
DJ