title: Determinants of survival after aortic valve replacement as treatment for symptomatic aortic valve disease in the elderly.
abstract: OBJECTIVE
  The effect of concurrent disease and cardiac comorbidity on survival after bioprosthetic valve replacement in elderly patients was assessed retrospectively. Risk factors were categorized as general, non-cardiac (age, diabetes, previously treated carcinoma) and cardiac (LVEF, three-vessel disease, previous CABG or valve replacement, and endocarditis).
  
  
  METHODS
  A total of 400 elderly patients (median age 73 years; range: 71-76 years) was studied. Medical history included diabetes, previous CABG or aortic valve replacement (AVR), endocarditis and treatment of previous carcinoma. A left ventricular ejection fraction (LVEF) of <0.66 and presence of three-vessel disease were also investigated. Hospital deaths (and cause) were recorded; survival or date and cause of death after discharge were obtained by questionnaire. Kaplan-Meier univariate and Cox proportional hazards multivariate regression analyses were carried out.
  
  
  RESULTS
  Mortality during follow up was 28.3%; hospital mortality was 3.8%. Univariate analysis showed five factors significantly to affect survival: LVEF, history of endocarditis, carcinoma, age and three-vessel disease. Fifteen of 38 patients with history of carcinoma died, 10 due to a malignancy. Of 76 patients with three-vessel disease, 26 died. A history of diabetes and previous CABG did not influence survival significantly. Four of eight patients with preoperative endocarditis died, all in hospital. Six of 11 patients died after redo-AVR, none before 36 months follow up. By Cox regression analysis, LVEF and histories of carcinoma and endocarditis remained significant.
  
  
  CONCLUSIONS
  AVR should be performed before ventricular deterioration occurs. Previous CABG is not a contraindication for AVR. Endocarditis impaired survival. Long-term mortality after redo-AVR in this population was relatively high, but acceptable. AVR should also be performed in elderly patients with aortic valve disease. Since prognosis of symptomatic aortic valve disease is poor in the short term, AVR is indicated in patients treated for carcinoma.
authors.affiliation: Laboratory for Human Anatomy, University of Antwerp, Belgium.
authors.forename: W P
authors.initials: WP
authors.lastname: Mistiaen
authors.forename: P
authors.initials: P
authors.lastname: Van Cauwelaert
authors.forename: P
authors.initials: P
authors.lastname: Muylaert
authors.forename: M
authors.initials: M
authors.lastname: Van Hove
authors.forename: S U
authors.initials: SU
authors.lastname: Sys
authors.forename: F
authors.initials: F
authors.lastname: Harrisson
authors.forename: J
authors.initials: J
authors.lastname: Bunarto
authors.forename: J
authors.initials: J
authors.lastname: Delaruelle
authors.forename: H
authors.initials: H
authors.lastname: Bortier
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis; D005260:Female; D006349:Heart Valve Diseases / Q000209:etiology / Q000401:mortality* / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D012307:Risk Factors; D015996:Survival Rate