Alcohol biomarkers: clinical significance and biochemical basis.
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Raj Lakshman and Mikihiro Tsutsumi. The presentations were (1) Sialic acid index of apolipoprotein J: A new marker for chronic alcohol consumption, by P. Ghosh and M. R. Lakshman; (2) Microheterogeneity of serum glycoproteins in alcoholics, by M. Tsutsumi and S. Takase; (3) Probing protein-ethanol adducts with combinatorial peptide libraries displayed by filamentous phage, by H. Anni, O. Nikolaeva, and Y. Israel Y; (4) Carbohydrate-deficient transferrin as a marker for heavy alcohol use: What have we learned; Where do we go from here, by R. F. Anton; (5) Sensitivity and specificity of carbohydrate-deficient transferrin in drinking experiments and different patient groups, by O. M. Lesch; (6), Transferrin variants interfere with the measurement of carbohydrate-deficient transferrin, by A. Helender, G. Eriksson, and J-O. Jeppson; and (7) Chronic ethanol on protein trafficking in liver, by P. Marmillot, M. N. Rao, and M. R. Lakshman.
Lakshman
R
R
Lipid Research Laboratory, DVA Medical Center and Department of Medicine, The George Washington University, Washington, DC 20422, USA.
Tsutsumi
M
M
Ghosh
P
P
Takase
S
S
Anni
H
H
Nikolaeva
O
O
Israel
Y
Y
Anton
R F
RF
Lesch
O M
OM
Helender
A
A
Eriksson
G
G
Jeppson
J O
JO
Marmillot
P
P
Rao
M N
MN
D000437:Alcoholism / Q000097:blood* / Q000175:diagnosis; D000818:Animals; D015415:Biomarkers / Q000097:blood; D051152:Clusterin; D006023:Glycoproteins / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism*; D018832:Molecular Chaperones / Q000097:blood*; D019158:N-Acetylneuraminic Acid / Q000097:blood*; D021381:Protein Transport / Q000502:physiology; D014168:Transferrin / Q000031:analogs & derivatives / Q000378:metabolism*
D015415:Biomarkers; C495242:CLU protein, human; D051152:Clusterin; D006023:Glycoproteins; D018832:Molecular Chaperones; D014168:Transferrin; C056759:carbohydrate-deficient transferrin; D019158:N-Acetylneuraminic Acid