[Cardioprotective effects of a new fluorine-containing synthetic activator of ATP-dependent potassium channels].
Effects of PF-10 the new fluorine-containing activator of ATP-dependent K-channels were investigated on the guinea-pig isolated heart. PF-10 enhanced myocardial contractility and decreased coronary vessels resistance in a dose-dependent manner. Low doses (10 mM/L, 1 mM/L) of PF-10 attenuates of the spontaneous alterations of heart rate, while high doses (0.1 mM/L) leds to these alterations. Previous activation of ATP-dependent K-channels by PF-10 has a cardioprotective effect during ischemia-reperfusion which a similar to the well-known phenomenon of ischemic preconditioning.
Strutyns'kyĭ
R B
RB
A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Moĭbenko
O O
OO
Iahupol's'kyĭ
L M
LM
Iuz'kiv
M Ia
MIa
Kvochina
L I
LI
Shysh
A M
AM
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D015221:Potassium Channels / Q000819:agonists* / Q000378:metabolism; D015427:Reperfusion Injury / Q000517:prevention & control*; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D015221:Potassium Channels; D014665:Vasodilator Agents; D000255:Adenosine Triphosphate