title: Unnatural natural products from the transannular cyclization of lathyrane diterpenes.
abstract: The potential of macrocyclic diterpenoids to afford natural product-like polycyclic compounds was demonstrated by the conversion of two lathyrane Euphorbia factors into a series of densely functionalized diterpenoids of unnatural skeletal type. Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity.
authors.affiliation: Università del Piemonte Orientale, DiSCAFF, Viale Ferrucci 33, 28100 Novara, Italy. appendin@pharm.unito.it
authors.forename: G
authors.initials: G
authors.lastname: Appendino
authors.forename: G C
authors.initials: GC
authors.lastname: Tron
authors.forename: T
authors.initials: T
authors.lastname: Jarevång
authors.forename: O
authors.initials: O
authors.lastname: Sterner
mesh_terms: D003500:Cyclization; D004224:Diterpenes / Q000737:chemistry*; D019665:Euphorbiaceae / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
chemical_list: D004224:Diterpenes; D011083:Polycyclic Compounds