A new method for chemoselective conjugation of unprotected peptides to dauno- and doxorubicin.
A new approach for chemoselective ligation of peptides to dauno- and doxorubicin through an oxime bond is presented. The method does not require protecting groups on the peptide moiety.
Ingallinella
P
P
Istituto di Ricerche di Biologia Molecolare P. Angeletti, Pomezia, Rome, Italy.
Marco
A D
AD
Taliani
M
M
Fattori
D
D
Pessi
A
A
D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003630:Daunorubicin / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D010455:Peptides; D004317:Doxorubicin; D003630:Daunorubicin