title: [Insisting on intravenous polyvalent immunoglobulin therapy in polymyositis in spite of the occurrence of sever hemolytic anemia].
abstract: A 23-year-old female with polymyositis received high dose intravenous immunoglobulin (IVIg) therapy. The patient suffered severe hemolytic anemia after receiving first course of IVIg infusion. This adverse reaction was likely due to allohemaglutinin A and B and from or high molecular weight IgG complexes contained in the preparation. Though this effect was observed, the treatment was repeated six times. A mild hemolysis occurred following each IVIg, with no clinical consequence. Involvement of the saturation of macrophagic receptors might explain this partial destruction of erythrocytes.
authors.affiliation: Hôpital Beaujon, 100, bd du Général-Leclerc, 92110 Clichy, France.
authors.forename: C
authors.initials: C
authors.lastname: Ballot-Brossier
authors.forename: R
authors.initials: R
authors.lastname: Mortelecque
authors.forename: M
authors.initials: M
authors.lastname: Sinègre
authors.forename: A
authors.initials: A
authors.lastname: Marceau
authors.forename: G
authors.initials: G
authors.lastname: Dauriat
authors.forename: F
authors.initials: F
authors.lastname: Courtois
mesh_terms: D018829:Adhesins, Bacterial; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology*; D001426:Bacterial Proteins / Q000276:immunology; D000075202:Contraindications; D005260:Female; D006388:Hemagglutinins / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects / Q000627:therapeutic use*; D037102:Lectins; D017285:Polymyositis / Q000150:complications* / Q000628:therapy*; D012008:Recurrence
chemical_list: D018829:Adhesins, Bacterial; D001426:Bacterial Proteins; C098582:HagB protein, Porphyromonas gingivalis; D006388:Hemagglutinins; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D037102:Lectins; C114923:hemagglutinin A, Porphyromonas gingivalis