Accelerated functional recovery after neuronal injury by P2 receptor blockade.
The effect of the P2 receptor antagonist pyridoxalphosphate-6-azophenyl-2',4'-disulphonic acid (PPADS) on changes of the quantitative electroencephalogram (EEG) after injury of rat brain tissue was investigated. PPADS accelerated the functional recovery from microdialysis probe-induced disturbances in the nucleus accumbens by a decrease of the ratio of absolute slow (0.6-4 Hz) to fast (8-30 Hz) power, mainly caused by a decrease in the delta frequency power. These data provide evidence for a possible neuroprotective effect of P2 receptor antagonists in vivo.
Krügel
U
U
Rudolf-Boehm-Institute of Pharmacology and Toxicology, University of Leipzig, Härtelstrasse 16-18, D-04107, Leipzig, Germany. krueu@medizin.uni-leipzig.de
Kittner
H
H
Franke
H
H
Illes
P
P
D000818:Animals; D001930:Brain Injuries / Q000503:physiopathology; D004569:Electroencephalography / Q000187:drug effects; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D058919:Purinergic P2 Receptor Antagonists; D011732:Pyridoxal Phosphate / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats
D058919:Purinergic P2 Receptor Antagonists; C077792:pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid; D011732:Pyridoxal Phosphate