title: [Prognostic outcome of leaking filtering blebs reconstruction with rotational conjunctival flaps].
abstract: OBJECTIVE
  Late bleb leaks may follow months to years after filtering surgery especially with the use of antimetabolites. Complications related to beb leaks may lead to a decrease in visual acuity through complicated hypotony or ocular infection. Our retrospective study reports the anatomical and functional results of bleb reconstruction involving the resection of the bleb associated with the covering of the trabeculectomy site with a rotational conjunctival flap.
  
  
  METHODS
  and methods: Twelve eyes of eleven patients with filtering bleb leaks occurring 3 months to 5 years after successful trabeculectomy (58.3% with adjunct of antimetabolites) underwent bleb surgical reconstruction between november 1995 and June 1999 and were followed until March 2000. Surgical bleb reconstruction was indicated because of persistent or a recurring bleb leak despite conservative medical treatment and blood bleb injections in seven cases. Complications associated with bleb leaks were chronical hypotony (9 cases), athalamy (1 case), hypotony maculopathy (1 case), and endophtalmitis with athalamy (1 case). Three patients had normal IOP but a bleb leak responsible for epiphora. All eyes were treated surgically through bleb excision and conjunctival closure was performed by rotational conjunctival flap.
  
  
  RESULTS
  Mean (+/- SD) preoperative IOP was 5.1+/-3.5mmHg (range: 2 to 14mmHg). Mean (+/- SD) postoperative IOP evaluated before any other operation for uncontrolled IOP was 12.7+/-3.1mmHg (range: 6 to 15mmHg). Mean follow-up was 26.7+/-16.9 months (range: 9 to 64 months). All the complications related to the bleb leak resolved after bleb reconstruction. Surgery definively stopped the leak in 10 cases (83.3%) and allowed IOP control without treatment in 50.0% of the cases. Chronic recurring bleb leaks without hypotony occurred in two eyes and required surgery with conjunctival graft which led to a refractory increase in IOP responsible for loss of vision in one case.
  
  
  CONCLUSIONS
  Bleb resection associated with the covering of the trabeculectomy site with a rotational conjunctival flap is a safe and effective procedure for the treatment of a late bleb leak and its complications. In most of the cases (83.3%), long-term IOP control can be expected without, medical treatment in 50% of the cases. Patients must be aware of the possibility of a recurring Seidel; however, the incidence of this complication remains low.
authors.affiliation: Centre Hospitalier National d'Ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris.
authors.forename: P
authors.initials: P
authors.lastname: Hamard
authors.forename: M
authors.initials: M
authors.lastname: Tazartes
authors.forename: T
authors.initials: T
authors.lastname: Ayed
authors.forename: S
authors.initials: S
authors.lastname: Quesnot
authors.forename: H
authors.initials: H
authors.lastname: Hamard
mesh_terms: D000328:Adult; D000368:Aged; D000963:Antimetabolites / Q000627:therapeutic use; D001768:Blister / Q000209:etiology* / Q000601:surgery*; D003131:Combined Modality Therapy; D003229:Conjunctival Diseases / Q000209:etiology* / Q000601:surgery*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D015812:Glaucoma, Angle-Closure / Q000601:surgery; D005902:Glaucoma, Open-Angle / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use; D018579:Patient Selection; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D013524:Surgical Flaps; D016019:Survival Analysis; D013997:Time Factors; D014130:Trabeculectomy / Q000009:adverse effects*; D016896:Treatment Outcome
chemical_list: D000963:Antimetabolites; D019384:Nucleic Acid Synthesis Inhibitors; D016685:Mitomycin; D005472:Fluorouracil