title: The allogeneic response and tumor immunity.
abstract: The strong allogeneic response to donor MHC molecules in transplantation and the weak response to tumor antigens represent two important and divergent but potentially interactive immune responses. A patient's response to allogeneic MHC molecules might promote an effective T-cell response to self MHC-restricted tumor peptides and the possibilities for this are discussed here. These allogeneic responses might successfully be harnessed to promote the immune eradication of metastatic cancer.
authors.affiliation: Department of Clinical Sciences, Institute of Liver Studies Guy's, King's and St Thomas' School of Medicine, London, UK. john.fabre@kcl.ac.uk
authors.forename: J W
authors.initials: JW
authors.lastname: Fabre
mesh_terms: D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D007519:Isoantigens / Q000276:immunology*; D008285:Major Histocompatibility Complex / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000503:physiopathology; D010455:Peptides / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D014184:Transplantation, Homologous
chemical_list: D006680:HLA Antigens; D007519:Isoantigens; D010455:Peptides