Dealing the CARDs between life and death.
Exciting evidence presented at a recent meeting shows that proteins containing CARD, or related DD or DED, motifs are centrally involved in assembling protein complexes that drive activation of either IkappaB kinase or caspases by facilitating intermolecular juxtapositioning. Thus, CARD-family proteins occupy crucial positions in divergent stress-associated signalling pathways that culminate in inflammatory responses or apoptosis.
Martin
S J
SJ
Dept of Genetics, The Smurfit Institute, Trinity College, Dublin, Ireland. martinsj@tcd.ie
D048868:Adaptor Proteins, Signal Transducing; D020816:Amino Acid Motifs; D017209:Apoptosis / Q000235:genetics / Q000502:physiology*; D053477:Apoptotic Protease-Activating Factor 1; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D008954:Models, Biological; D016328:NF-kappa B / Q000378:metabolism; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism
C506592:APAF1 protein, human; D048868:Adaptor Proteins, Signal Transducing; D053477:Apoptotic Protease-Activating Factor 1; D002352:Carrier Proteins; D047908:Intracellular Signaling Peptides and Proteins; D016328:NF-kappa B; C119067:NOD1 protein, human; C429018:NOD2 protein, human; D053474:Nod1 Signaling Adaptor Protein; D053473:Nod2 Signaling Adaptor Protein; D011506:Proteins