Hydroxyethylstarch versus human albumin for the treatment of severe ovarian hyperstimulation syndrome: a preliminary report.
OBJECTIVE
To compare the efficacy and safety of 6% hydroxyethylstarch and human albumin as colloid solutions for treatment of severe ovarian hyperstimulation syndrome (OHSS).


METHODS
Controlled cohort study.


METHODS
Tertiary medical center.


METHODS
Sixteen patients with severe OHSS.


METHODS
Six percent hydroxyethylstarch (6 patients) and human albumin (10 patients).


METHODS
Urine output, number of abdominal and pleural drainage procedures, complications, duration of hospitalization, and perinatal outcome.


RESULTS
Patients who received 6% hydroxyethylstarch had higher urine output, needed fewer abdominal and pleural paracenteses, and had a shorter hospital stay than those who received human albumin. In each group, no adverse effects or congenital malformations were observed and the rates of miscarriage were similar.


CONCLUSIONS
These results suggest that 6% hydroxyethylstarch may be superior to albumin as a colloid solution for the treatment of severe OHSS.
Abramov
Y
Y
Department of Obstetrics and Gynecology, Hebrew University Hadassah Medical Center, Jerusalem, Israel.abramo@md2.huji.ac.il
Fatum
M
M
Abrahamov
D
D
Schenker
J G
JG
D000328:Adult; D004231:Diuresis / Q000187:drug effects; D005260:Female; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use*; D007902:Length of Stay; D016471:Ovarian Hyperstimulation Syndrome / Q000188:drug therapy* / Q000503:physiopathology* / Q000628:therapy; D019152:Paracentesis; D012709:Serum Albumin / Q000627:therapeutic use*; D012720:Severity of Illness Index
D006895:Hydroxyethyl Starch Derivatives; D012709:Serum Albumin