title: Preoperative radiotherapy without femoral shielding for prevention of heterotopic ossification in hydroxyapatite-coated hip prostheses.
abstract: Twenty-seven consecutive patients at high risk of developing heterotopic ossifications (HO) after implantation of a hydroxyapatite (HA)-coated hip prosthesis were irradiated with a single dose of 7 Gy, at least 4 h before the operation. The femoral stem was not shielded during radiotherapy (RT). After a median follow-up of 14.8 months, no clinically significant HO could be found, while 12 (52%) patients in this high-risk population had only minor HO (grade I). No reoperation was needed, and no evidence of prosthesis migration was observed. We conclude that single-dose, preoperative RT for HA-coated hip prosthesis can effectively inhibit HO. Not blocking the femoral stem does not result in prosthesis migration.
authors.affiliation: Department of Radiotherapy, Triemli Hospital, Zürich, Switzerland. dantaussky@hotmail.com
authors.forename: D
authors.initials: D
authors.lastname: Taussky
authors.forename: M
authors.initials: M
authors.lastname: Cserhati
authors.forename: R
authors.initials: R
authors.lastname: Pescia
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019644:Arthroplasty, Replacement, Hip / Q000009:adverse effects*; D020099:Coated Materials, Biocompatible; D017886:Durapatite; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000517:prevention & control* / Q000532:radiotherapy*; D011300:Preoperative Care; D011474:Prosthesis Design; D011879:Radiotherapy Dosage
chemical_list: D020099:Coated Materials, Biocompatible; D017886:Durapatite