title: Association analysis of NOTCH4 loci in schizophrenia using family and population-based controls.
abstract: A genetic association between NOTCH4 and schizophrenia has previously been proposed. Unsing all markers previously shown to be associated, we found no evidence for such in three independent family-based samples (n=519 parent-offspring trios), and a case-control sample derived from the same ethnic background as the original observation. These data strongly suggest that NOTCH4 is not a significant susceptibility allele for schizophrenia.
authors.affiliation: Department of Psychiatry, Massachusetts General Hospital, Boston, Massachusetts, USA. sklar@genome.wi.mit.edu
authors.forename: P
authors.initials: P
authors.lastname: Sklar
authors.forename: S G
authors.initials: SG
authors.lastname: Schwab
authors.forename: N M
authors.initials: NM
authors.lastname: Williams
authors.forename: M
authors.initials: M
authors.lastname: Daly
authors.forename: S
authors.initials: S
authors.lastname: Schaffner
authors.forename: W
authors.initials: W
authors.lastname: Maier
authors.forename: M
authors.initials: M
authors.lastname: Albus
authors.forename: M
authors.initials: M
authors.lastname: Trixler
authors.forename: P
authors.initials: P
authors.lastname: Eichhammer
authors.forename: B
authors.initials: B
authors.lastname: Lerer
authors.forename: J
authors.initials: J
authors.lastname: Hallmayer
authors.forename: N
authors.initials: N
authors.lastname: Norton
authors.forename: H
authors.initials: H
authors.lastname: Williams
authors.forename: S
authors.initials: S
authors.lastname: Zammit
authors.forename: A G
authors.initials: AG
authors.lastname: Cardno
authors.forename: S
authors.initials: S
authors.lastname: Jones
authors.forename: G
authors.initials: G
authors.lastname: McCarthy
authors.forename: V
authors.initials: V
authors.lastname: Milanova
authors.forename: G
authors.initials: G
authors.lastname: Kirov
authors.forename: M C
authors.initials: MC
authors.lastname: O'Donovan
authors.forename: E S
authors.initials: ES
authors.lastname: Lander
authors.forename: M J
authors.initials: MJ
authors.lastname: Owen
authors.forename: D B
authors.initials: DB
authors.lastname: Wildenauer
mesh_terms: D016022:Case-Control Studies; D002896:Chromosomes, Human, Pair 6; D005828:Genetics, Population; D006801:Humans; D015810:Linkage Disequilibrium; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D000074562:Receptor, Notch4; D011956:Receptors, Cell Surface; D051880:Receptors, Notch; D012559:Schizophrenia / Q000235:genetics*; D006113:United Kingdom
chemical_list: C106075:NOTCH4 protein, human; D011518:Proto-Oncogene Proteins; D000074562:Receptor, Notch4; D011956:Receptors, Cell Surface; D051880:Receptors, Notch