[Color reactions for identification of sodium cromoglycate].
Chromone-2-carboxylic acid (3) reacts with aminopyrazolone (2) in methanolic hydrochloric acid to yield the orange-red polymethine dye 4. Treating dimethyl cromoglicate (6) with compound 2 and perchloric acid leads to the tetraperchlorate 7 of the red azamerocyanine 8. The phenol 9, obtained from alkaline hydrolysis of sodium cromoglicate (1a), couples with diazotized sulfanilic acid to form the red azo dye 10. The chromone 6 condenses with 1,3-dimethylbarbituric acid (DMBA) in acetic anhydride/acetic acid to the red oxonole 12. Cromoglicinic acid (1b) reacts under these conditions to yield the yellow polymethine dye 14, whose structure is elucidated by X-ray analysis.
Görlitzer
K
K
Institut für Pharmazeutische Chemie, Technischen Universität Braunschweig, Germany. k.goerlitzer@tu-bs.de
Badia
G
G
Jones
P G
PG
D018927:Anti-Asthmatic Agents / Q000032:analysis*; D003116:Color; D004396:Coloring Agents; D004205:Cromolyn Sodium / Q000032:analysis*; D018360:Crystallography, X-Ray; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation
D018927:Anti-Asthmatic Agents; D004396:Coloring Agents; D007202:Indicators and Reagents; D004205:Cromolyn Sodium