title: Improved prediction of intraocular lens power using partial coherence interferometry.
abstract: OBJECTIVE
  To evaluate the feasibility of using a new optical biometry technique, dual-beam partial coherence interferometry (PCI), to improve intraocular lens (IOL) power prediction in cataract surgery.
  
  
  METHODS
  Department of Ophthalmology, Vienna General Hospital, and Institute of Medical Physics, University of Vienna, Vienna, Austria.
  
  
  METHODS
  Preoperative axial length (AL) data obtained with PCI biometry and applanation ultrasound (US) biometry in 77 eyes of 51 patients was applied to 4 commonly used IOL power formulas. The refractive outcome and the mean absolute error (MAE) were calculated for each formula using both biometry methods. A linear multiple-regression model based on preoperative PCI biometry data was derived to predict the postoperative anterior chamber depth (ACD). The predictive power of this regression model was assessed by adding the predicted ACD to the SRK/T formula. Predicted residuals were calculated to evaluate the feasibility and stability of this modified IOL power formula.
  
  
  RESULTS
  Using PCI instead of US biometry significantly improved the refractive outcome with all 4 IOL power formulas. The Holladay I and SRK/T formulas yielded an MAE of 0.44 diopter (D) using PCI AL data and 0.56 D and 0.57 D, respectively, using US biometry data. The SRK/T formula combined with the PCI regression model for postoperative ACD prediction performed slightly better (MAE 0.42 D) than the conventional SRK/T formula alone. Predicted residuals revealed an MAE of 0.46 D, proving the predictive performance of the new formula.
  
  
  CONCLUSIONS
  Partial coherence interferometry biometry applied to several widely used IOL power formulas yielded significantly better IOL power prediction and therefore refractive outcome in cataract surgery than US biometry. Further improvement can be achieved by applying PCI to a modified SRK/T formula that predicts the postoperative ACD using PCI biometry data.
authors.affiliation: Department of Ophthalmology, Vienna General Hospital, Vienna, Austria.
authors.forename: O
authors.initials: O
authors.lastname: Findl
authors.forename: W
authors.initials: W
authors.lastname: Drexler
authors.forename: R
authors.initials: R
authors.lastname: Menapace
authors.forename: H
authors.initials: H
authors.lastname: Heinzl
authors.forename: C K
authors.initials: CK
authors.lastname: Hitzenberger
authors.forename: A F
authors.initials: AF
authors.lastname: Fercher
mesh_terms: D001699:Biometry / Q000379:methods; D002387:Cataract Extraction; D003941:Diagnostic Techniques, Ophthalmological; D005240:Feasibility Studies; D006801:Humans; D007368:Interferometry; D019654:Lens Implantation, Intraocular; D007910:Lenses, Intraocular; D055095:Optics and Photonics; D013016:Sound