[Visual impairment due to optic neuropathy in 2 patients on amiodarone therapy, i.e. ethambutol and isoniazide].
Two patients, a 69-year-old man and a 49-year-old woman, developed a bilateral decrease in visual acuity, the male patient within two months of starting to use amiodarone (Cordarone) and the female patient within ten months of starting to use ethambutol (Myambutol) and isoniazid. Optic neuropathy occurred in both patients and this was probably caused by the medications. After the medication had been withdrawn, the male patient's vision remained poor (1/300); 6 months later the female patient's vision had improved to 0.8 and 1.0. Before prescribing oculotoxic medications, physicians should know about the patient's visual acuity and any ocular diseases the patient may have. The patient must also be advised to contact their doctor immediately if visual complaints occur. Before and during treatment with ethambutol, ophthalmological examinations should be carried out regularly. In the event of complaints, iatrogenic optic neuropathy must be distinguished from an ischaemic optic neuropathy. The latter is usually associated with an acute unilateral decrease in visual acuity. Withdrawal of the medication is indicated for neuropathy. However, although the vision may improve it will not be completely restored.
Polak
B C
BC
Academisch Ziekenhuis Vrije Universiteit, afd. Oogheelkunde, Postbus 7057, 1007 MB Amsterdam.
Tutein Nolthenius
P A
PA
Rietveld
E
E
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000139:chemically induced* / Q000175:diagnosis; D018917:Optic Neuropathy, Ischemic / Q000175:diagnosis; D020127:Recovery of Function; D015354:Vision, Low / Q000139:chemically induced*
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone