title: Possible antineoplastic agents, part 15: synthesis, biological activity and quantitative structure activity relationship of substituted-2-(4'-methoxybenzenesulphonamido) glutaric acid analogs against Ehrlich ascites carcinoma.
abstract: Some substituted-2-(4'-methoxybenzenesulphonamido) glutaric acid analogs (5a-m, 7a-d) have been synthesized and tested for their possible antineoplastic activity against Ehrlich ascites carcinoma (EAC) in Swiss albino mice using tumour (ascitic fluid) weight as activity parameter. Some of these compounds possess encouraging antitumour activity. A QSAR study, performed by the classical Hansch method, explains the significance of hydrophobic binding and electronic influence in the mechanism of antineoplastic action in this group of compounds.
authors.affiliation: Division of Medicinal and Pharmaceutical Chemistry, Department of Pharmaceutical Technology, Jadavpur University, Calcutta, India.
authors.forename: D
authors.initials: D
authors.lastname: Goswami
authors.forename: S
authors.initials: S
authors.lastname: Sen
authors.forename: A U
authors.initials: AU
authors.lastname: De
mesh_terms: D000465:Algorithms; D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005260:Female; D005977:Glutarates / Q000138:chemical synthesis* / Q000737:chemistry; D051379:Mice; D021281:Quantitative Structure-Activity Relationship; D013449:Sulfonamides / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D000970:Antineoplastic Agents; D005977:Glutarates; D013449:Sulfonamides