title: Effect of beta-cyclodextrin on the hydrolysis of trifluoroacetate esters.
abstract: The hydrolysis of p-F, p-Cl, and m-Cl phenyl trifluoracetates was studied in the presence of beta-cyclodextrin (beta-CD). The reactions are inhibited by beta-CD at pH 6 while they are catalyzed in alkaline solution. MM3 calculations reproduce some of the experimental results. The substrates form inclusion complexes with beta-CD which are of similar stability as those of the corresponding acetates; however, the association of the transition state is less favorable in these reactions than in those of the acetates, and consequently less stronger catalysis is observed.
authors.affiliation: Departament de Química, Facultat de Ciències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
authors.forename: M A
authors.initials: MA
authors.lastname: Fernández
authors.forename: R H
authors.initials: RH
authors.lastname: de Rossi
authors.forename: E
authors.initials: E
authors.lastname: Cervelló
authors.forename: C
authors.initials: C
authors.lastname: Jaime