Description of a new HLA-DRB1 allele, DRB1*1139.
We report the identification of a novel DRB1*11 using sequence-based typing. This new allele, officially named DRB1*1139, was detected while performing HLA-DRB1 high-resolution typing of a volunteer bone marrow donor. DRB1*1139 is identical to DRB1*11011 except at codon 51 (ACG-->AGG) changing the encoded Threonine to Arginine. The triplet AGG has never been found in any other DRB1 allele. In fact, with standard polymerase chain reaction (PCR) amplification with sequence specific primers, the presented allele would have been interpreted as DRB1*1101 (Note).
Longhi
E
E
Centro Trasfusionale e di Immunologia dei Trapianti, Milan, Italy.
Frison
S
S
Poli
F
F
Scalamogna
M
M
Sirchia
G
G
D000483:Alleles; D016026:Bone Marrow Transplantation / Q000276:immunology; D006684:HLA-DR Antigens / Q000235:genetics*; D059811:HLA-DRB1 Chains; D006801:Humans; D008969:Molecular Sequence Data
D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; C553518:HLA-DRB1*11:01:01 antigen; C553513:HLA-DRB1*11:39 antigen