Antifungal polysulphides from Petiveria alliacea L.
Bioactivity-directed fractionation of the CH(2)Cl(2)/MeOH (2:1, v/v) extract of the roots of Petiveria alliacea, using mutant yeast strains of Saccharomyces cerevisiae and fungi Cladosporium cladosporioides and C. sphaerospermum led to the isolation of dipropyl disulphide (1), dibenzyl sulphide (2), dibenzyl disulphide (3), dibenzyl trisulphide (4), dibenzyl tetrasulphide (5), benzylhydroxymethyl sulphide (6) and di(benzyltrithio) methane (7). Of these, 5-7 are new compounds and this is the first report of the natural occurrence of 2 and 3.
Benevides
P J
PJ
Instituto de Química, Universidade de São Paulo, C.P. 26077, CEP 05599-970, SP, Brazil.
Young
M C
MC
Giesbrecht
A M
AM
Roque
N F
NF
Bolzani
V S
VS
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification*; D019684:Magnoliopsida / Q000737:chemistry*; D013057:Spectrum Analysis; D013440:Sulfides / Q000737:chemistry / Q000302:isolation & purification*
D000935:Antifungal Agents; D013440:Sulfides