title: Activated protein C and inflammation in human myocardium after heart surgery.
abstract: To assess possible interactions between inflammation and activation of the anticoagulant protein C system during post-ischemic reperfusion protein C, APC, neutrophil L-selectin expression and myocardial myeloperoxidase activity (MPO) were measured in 19 patients undergoing cardiopulmonary bypass. After reperfusion for 10 min, APC to protein C ratio (APC/PC) increased from pre-reperfusion value 1.43 +/- 0.12 (mean +/- SEM) to 2.25 +/- 0.29, p = 0.015. Negative correlations were observed between APC/PC and MPO activity (Spearman r -0.64, p = 0.007) and APC/PC and neutrophil L-selectin expression (r = -0.7, p = 0.007, demonstrating that post-ishemic protein C activation was associated with decreased neutrophil tissue sequestration. Thus, physiological protein C activation may be involved in regulation of the inflammatory injury during reperfusion of human ischemic coronary circulation.
authors.affiliation: Hospital for Children and Adolescents, University of Helsinki, Helsinki, Finland. jari.petaja@dlc.fi
authors.forename: J
authors.initials: J
authors.lastname: Petäjä
authors.forename: E
authors.initials: E
authors.lastname: Pesonen
authors.forename: J A
authors.initials: JA
authors.lastname: Fernández
authors.forename: J H
authors.initials: JH
authors.lastname: Griffin
authors.forename: H
authors.initials: H
authors.lastname: Repo
authors.forename: S E
authors.initials: SE
authors.lastname: Jansson
authors.forename: A E
authors.initials: AE
authors.lastname: Vento
authors.forename: O J
authors.initials: OJ
authors.lastname: Rämö
mesh_terms: D000328:Adult; D000368:Aged; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D004789:Enzyme Activation; D006324:Heart Arrest, Induced / Q000009:adverse effects; D006801:Humans; D019041:L-Selectin / Q000032:analysis; D008297:Male; D008875:Middle Aged; D015428:Myocardial Reperfusion Injury / Q000097:blood* / Q000209:etiology; D009205:Myocarditis / Q000209:etiology*; D009504:Neutrophils / Q000201:enzymology; D009195:Peroxidase / Q000032:analysis; D011486:Protein C / Q000032:analysis*
chemical_list: D011486:Protein C; D019041:L-Selectin; D009195:Peroxidase