Therapeutic potential of the intestinotropic hormone, glucagon-like peptide-2.
Glucagon-like peptide-2 (GLP-2) is a newly discovered growth factor that has been demonstrated to enhance intestinal growth and function in normal rodents and to prevent damage and facilitate intestinal repair in various animal models of intestinal insufficiency. A recent study has demonstrated that GLP-2 also acts as an intestinotropin in humans with short-bowel syndrome. The high degree of specificity of GLP-2 for induction of intestinal growth, without affecting growth of other peripheral tissues, is determined by the highly localized expression of the GLP-2 receptor in the intestinal epithelium. In this article, we review the regulation of GLP-2 in physiology, from synthesis to metabolism, with a particular emphasis on potential targets in this pathway for therapeutic manipulation of GLP-2 actions. We also discuss the various animal models of intestinal insufficiency that have been used to demonstrate the therapeutic potential of this intestinotropic hormone, including short bowel, intestinal atrophy, enteritis and colitis. The results of these studies indicate that GLP-2 is a promising therapeutic agent for the treatment of various forms of intestinal insufficiency in humans.
L'Heureux
M C
MC
Department of Physiology, University of Toronto, Ontario, Canada.
Brubaker
P L
PL
D000818:Animals; D005768:Gastrointestinal Hormones / Q000502:physiology* / Q000627:therapeutic use*; D053767:Glucagon-Like Peptide 2; D004763:Glucagon-Like Peptides; D006133:Growth Substances / Q000502:physiology / Q000627:therapeutic use; D006801:Humans; D007410:Intestinal Diseases / Q000188:drug therapy* / Q000517:prevention & control; D023421:Models, Animal; D010455:Peptides / Q000502:physiology* / Q000627:therapeutic use*
D005768:Gastrointestinal Hormones; D053767:Glucagon-Like Peptide 2; D006133:Growth Substances; D010455:Peptides; D004763:Glucagon-Like Peptides