title: [Arterial thrombolysis and angioplasty in atheromatous basilar artery occlusion].
abstract: Basilar occlusions treated with conventional therapy (anticoagulants or antiplatelets) have a poor outcome (80p. cent mortality). This unfavorable outcome may require a treatment within 6 hours by intra-arterial thrombolysis, sometimes followed by percutaneous transluminal angioplasty (PTA) in case of atherothrombotic occlusion due to a tight atherosclerotic stenosis. A 48 year-old patient, presented with left hemiparesis, left multimodal hypoesthesia, paralytic dysarthria. CT-scan showed a spontaneous hyperdensity of the basilar artery and arterial occclusion was confirmed by angiography, which showed an atherothrombotic occlusion involving the proximal part of the vessel. Intra-arterial thrombolysis began five hours after the onset with 0,25mg/kg of Rt-Pa (Actilyse((R))), given by bolus followed by 4 others bolus of 10mg. After a total dose of 60mg, arterial recanalization was obtained showing a tight atherosclerotic stenosis involving the proximal part of the basilar artery. PTA was performed 18 hours later with a ballon inflation at 6 atmospheres during 20 seconds. It allowed to decrease the stenosis from 80p. cent to 60p. cent. The patient recovered and MRI at D20 showed a small right lateral infarct involving the pons. Our study confirms the usefulness of intra-arterial thrombolysis in basilar artery occlusion. Consecutive PTA may be proposed in case of associated atherosclerotic stenosis, and the interest of PTA is further discussed.
authors.affiliation: Service de Neurologie A, CHU de Montpellier, Cedex 5, France.
authors.forename: D
authors.initials: D
authors.lastname: Milhaud
authors.forename: M
authors.initials: M
authors.lastname: Charif
authors.forename: C
authors.initials: C
authors.lastname: Héroum
authors.forename: P
authors.initials: P
authors.lastname: Smadja
authors.forename: A
authors.initials: A
authors.lastname: Bonafé
authors.forename: M
authors.initials: M
authors.lastname: Pagès
authors.forename: J M
authors.initials: JM
authors.lastname: Blard
mesh_terms: D000800:Angioplasty, Balloon; D001161:Arteriosclerosis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*; D004401:Dysarthria / Q000209:etiology; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D010291:Paresis / Q000209:etiology; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed; D014715:Vertebrobasilar Insufficiency / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000628:therapy*
chemical_list: D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator