title: Heart rate, neuroendocrine, and immunological reactivity in response to an acute laboratory stressor.
abstract: OBJECTIVE
  The primary objective of the present study was to identify neuroendocrine and immunological correlates of cardiovascular reactivity to an acute laboratory stressor.
  
  
  METHODS
  Subjects were 56 healthy volunteers. Heart rate and blood pressure were assessed at regular intervals during a 30-minute adaptation period and a 6-minute videotaped speech task. Blood was drawn before and after the task and was assayed for natural killer cell activity (NKCA), cortisol production, in vitro interferon gamma (IFN-gamma) and interleukin 10 production by peripheral blood mononuclear cells (PBMC), and antibody titers to the Epstein-Barr virus. Psychological measures were also administered.
  
  
  RESULTS
  NKCA increased significantly in response to the task, and this increase was significantly and positively correlated with heart rate reactivity. IFN-gamma production by PBMC also increased in response to the task, but these increases were unrelated to heart rate reactivity. In addition, baseline cortisol levels were found to be predictive of heart rate reactivity. Finally, questionnaire data were modestly related to various aspects of stress-induced reactivity.
  
  
  CONCLUSIONS
  Consistent with the task-related increases in NKCA and IFN-gamma, acute stress may signal an increase in at least some aspects of the cell-mediated, or TH1-driven, immune response. Furthermore, the finding that heart rate reactivity was related in part to baseline individual differences in cortisol production suggests that short-term cardiovascular responses to stress may be directly related to longer-term neuroendocrine modulation. Finally, the present results also help to highlight the influence of both sympathetic and nonsympathetic pathways in the response to acute stressors and suggest tentative links between certain psychological traits and various aspects of stress-induced reactivity.
authors.affiliation: Center for Psychoneuroimmunology Research, University of Rochester Medical Center, New York 14642, USA. Mark_Larson@urmc.rochester.edu
authors.forename: M R
authors.initials: MR
authors.lastname: Larson
authors.forename: R
authors.initials: R
authors.lastname: Ader
authors.forename: J A
authors.initials: JA
authors.lastname: Moynihan
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000786:Anger; D020031:Epstein-Barr Virus Infections / Q000276:immunology*; D005260:Female; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological / Q000276:immunology* / Q000503:physiopathology; D011795:Surveys and Questionnaires; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology*
chemical_list: D014409:Tumor Necrosis Factor-alpha