title: Clinical characteristics and catheter ablation of left ventricular outflow tract tachycardia.
abstract: Left ventricular outflow tract (LVOT) tachycardia is an uncommon form of idiopathic ventricular tachycardia (IVT). The underlying mechanism of this arrhythmia appears to be cyclic AMP-medicated triggered activity. The tachycardia occurs in the absence of structural heart disease and is generally benign, presenting commonly as palpitations and presyncope. It can manifest either a right or left bundle branch block morphology with an inferior axis. Subtle variations in the QRS morphology in leads I, V1, and V2 can help in localizing the anatomic site of origin (SOO). The arrhythmia is typically responsive to a variety of pharmacologic agents (beta-blockers, calcium channel blockers, Class I and II agents). Radiofrequency catheter ablation of LVOT tachycardia SOO as determined by pace mapping is quite efficacious (success rates of 90%). Magnetic electroanatomic mapping augments this by permitting three-dimensional catheter mapping and reproducible localization of the SOO. Catheter ablation should be considered relatively early in patients who experience severe symptoms with their arrhythmia and have failed, or are reluctant to take medications for the disorder.
authors.affiliation: Division of Cardiovascular Medicine, Hospital of the University of Pennsylvania, 9 Founders, 3400 Spruce Street, Philadelphia, PA 19104-4283, USA.
authors.forename: S
authors.initials: S
authors.lastname: Dixit
authors.forename: F E
authors.initials: FE
authors.lastname: Marchlinski
mesh_terms: D017115:Catheter Ablation; D006801:Humans; D013610:Tachycardia / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D014694:Ventricular Outflow Obstruction / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*