[Observations on the increased serum levels of YKL-40 in patients with rheumatoid arthritis and osteoarthritis].
BACKGROUND
This study aimed to evaluate the function of glycoprotein YKL-40 in patients with rheumatoid arthritis, erosive osteoarthrosis or coxitis.


METHODS
Serum levels of glycoprotein YKL-40 were assayed using an ELISA method in 40 patients with active-phase rheumatoid arthritis and 20 patients suffering from erosive osteoarthrosis or coxitis.


RESULTS
The mean values of YKL-40 were enhanced in all patients with rheumatoid arthritis and arthrosis with higher mean values in erosive osteoarthritis and coxitis (440 ng/ml) compared to rheumatoid arthritis (190 ng/ml).


CONCLUSIONS
YKL 40 is a local prognostic marker of joint destruction.
Morgante
M
M
Istituto di Medicina Interna, Sezione Reumatologia, Università degli Studi, Pisa, Italy.
Metelli
M R
MR
Morgante
D
D
D054392:Adipokines; D001172:Arthritis, Rheumatoid / Q000097:blood*; D001324:Autoantigens / Q000097:blood*; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D037102:Lectins; D010003:Osteoarthritis / Q000097:blood*
D054392:Adipokines; D001324:Autoantigens; C084533:CHI3L1 protein, human; D000071451:Chitinase-3-Like Protein 1; D006023:Glycoproteins; D037102:Lectins