title: [Therapy of osteoporosis from the viewpoint of evidence-based medicine].
abstract: DEFINITION AND SOCIOECONOMIC ASPECTS: Osteoporosis is a disease characterized by low bone mass and an increased susceptibility to fractures. It represents an enormous burden for the social security systems in developed countries. In Germany, approximately two million women and 800,000 men suffer from vertebral fractures and estimates for hip fracture incidence are in the range of 70,000-130,000 per year. The resulting costs for hip fractures alone could be calculated to 3-5 billion German marks. THERAPY ACCORDING TO EVIDENCE-BASED MEDICINE (EBM): According to Sackett et al. 1996, evidence-based medicine is the conscientious, explicit, and judicious use of current best evidence in making decisions about the care of individual patients. The practice of evidence-based medicine means integrating individual clinical expertise with the best available external evidence from systematic research. OSTEOPOROSIS THERAPY: The goal of osteoporosis therapy is to prevent fractures and several therapeutic options are available for this disease. With respect to proven fracture benefit, however, the quality of evidence from randomized clinical trials varies substantially among therapies. From systematic research the best external evidence is available for a supplementation with calcium and vitamin D and a therapy with the bisphosphonates alendronate or risedronate, as well as the SERM raloxifene. For other therapeutic agents like fluorides, vitamin D metabolites, calcitonin, and etidronate the quality of evidence is much lower. So far, there is no evidence for other pharmaceutical therapies. Hip protectors are effective for the prevention of hip fractures.
authors.affiliation: Klinik Der Fürstenhof und Institut für Klinische Osteologie Gustav Pommer, Bad Pyrmont. iko_pyrmont@t-online.de
authors.forename: M
authors.initials: M
authors.lastname: Pfeifer
authors.forename: R
authors.initials: R
authors.lastname: Lehmann
authors.forename: H W
authors.initials: HW
authors.lastname: Minne
mesh_terms: D002986:Clinical Trials as Topic; D019317:Evidence-Based Medicine; D005260:Female; D005598:Fractures, Spontaneous / Q000517:prevention & control; D006620:Hip Fractures / Q000517:prevention & control; D006801:Humans; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy* / Q000209:etiology; D016103:Spinal Fractures / Q000517:prevention & control