Improved resolution in proton NMR spectroscopy of powdered solids.
We present a new solid-state nuclear magnetic resonance experiment that yields, under CRAMPS decoupling conditions, a significant reduction in proton line widths for powdered organic solids. This experiment which relies on a constant-time acquisition of the proton transverse magnetization, removes the contribution of nonrefocusable broadening from the proton line widths. Although this new technique suffers from relatively low sensitivity, we demonstrate in this paper its feasibility on two model samples, L-alanine and the dipeptide Ala-Asp. In both cases a factor of between 2 and 3 in line width reduction is obtained for most of the proton resonances.
Lesage
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Laboratoire de Stéréochimie et des Interactions Moléculaires, UMR-5532 CNRS/ENS, Ecole Normale Supérieure de Lyon, 69364 Lyon, France.
Duma
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Sakellariou
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Emsley
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D000409:Alanine / Q000737:chemistry; D004151:Dipeptides / Q000737:chemistry; D008280:Magnetics; D019906:Nuclear Magnetic Resonance, Biomolecular / Q000295:instrumentation / Q000379:methods*; D011208:Powders / Q000737:chemistry; D011522:Protons; D012680:Sensitivity and Specificity
D004151:Dipeptides; D011208:Powders; D011522:Protons; C038047:alanylaspartic acid; D000409:Alanine