title: Morphological analysis of nevoid melanoma: a study of 20 cases with a review of the literature.
abstract: Nevoid melanoma is a rare variant of melanoma characterized by deceptive morphologic features reminiscent of a benign melanocytic nevus. Twenty (13 nodular, 7 verrucous) nevoid melanomas were reviewed with the goal of identifying the predominant architectural patterns, cytologic features, and prognostic indicators. Although at scanning magnification, many lesions showed a strong resemblance to banal compound or dermal nevi, careful inspection in all cases demonstrated subtle pleomorphism and impaired maturation with depth, invariably accompanied by multiple dermal mitoses. Four tumors recurred and three metastasized, with subsequent death of the patients. Follow-up information for a period of at least 3 years was available in eight cases. In this group, mortality was 37.5%, the metastasis rate was 37.5%, and the local recurrence rate was 75%, with an average tumor thickness of 2.5 mm. We conclude that nevoid melanoma may be distinguished from a benign melanocytic nevus by a high index of suspicion, a careful analysis of architecture, and attention to cytologic features. Our data and a review of the literature do not support the notion that nevoid melanoma has a better prognosis than ordinary melanoma.
authors.affiliation: Division of Dermatopathology, Department of Pathology, Brigham and Women's Hospital, 75 Francis Street, Boston, MA 02115, USA.
authors.forename: A
authors.initials: A
authors.lastname: Zembowicz
authors.forename: M
authors.initials: M
authors.lastname: McCusker
authors.forename: C
authors.initials: C
authors.lastname: Chiarelli
authors.forename: A P
authors.initials: AP
authors.lastname: Dei Tos
authors.forename: S R
authors.initials: SR
authors.lastname: Granter
authors.forename: E
authors.initials: E
authors.lastname: Calonje
authors.forename: P H
authors.initials: PH
authors.lastname: McKee
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology* / Q000556:secondary; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D009508:Nevus, Pigmented / Q000473:pathology; D011379:Prognosis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate