title: [Jet leg].
abstract: The aim of the paper is to give a review of jet-lag (Time Zone Change Syndrome) with regard to aetiology, symptomatology and pathophysiology. Furthermore we give recommendations on treatment of jet-lag. The literature has focused intensely on the potential benefit of phototherapy and/or use of melatonin as treatment modalities for jet-lag. Both phototherapy and melatonin have the capability to accelerate reentrainment of the circadian rhythm after flights across multiple time zones, thereby reducing jet-lag. We stress the importance of correct timing of phototherapy and use of melatonin and suggest that the traveller adapts to the "social" rhythm at the flight destination as well.
authors.affiliation: H:S Hvidovre Hospital, medicinsk endokrinologisk afdeling.
authors.forename: A L
authors.initials: AL
authors.lastname: Christiansen
authors.forename: S
authors.initials: S
authors.lastname: Madsbad
mesh_terms: D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects / Q000502:physiology; D006801:Humans; D020179:Jet Lag Syndrome / Q000209:etiology / Q000503:physiopathology / Q000517:prevention & control; D008550:Melatonin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D010789:Phototherapy; D017410:Practice Guidelines as Topic; D014195:Travel
chemical_list: D008550:Melatonin