Effect of administration route on FES uptake into MCF-7 tumors.
We have observed that intraperitoneal administration of [(18)F]fluoroestradiol (FES), a radiolabeled estrogen receptor ligand, results in higher abdominal organ uptake and slower blood clearance than intravenous administration in female mice. In SCID mice bearing MCF-7 human tumors SC, IP administration resulted in tumor uptake that was only about one third that obtained with IV administration. Thus, the route of administration of a radiopharmaceutical for imaging or radiotherapy of a tumor in the abdomen, an ovarian tumor, for example, could have a profound effect on the efficiency and selectivity of delivery of the agent to the tumor.
Downer
J B
JB
Department of Chemistry, Washington University, St. Louis, MO, USA.
Jones
L A
LA
Katzenellenbogen
J A
JA
Welch
M J
MJ
D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D004958:Estradiol / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D051379:Mice; D014407:Tumor Cells, Cultured
C062756:1-fluoroestradiol; D004958:Estradiol