[Chronic complication of diabetes and homocysteine].
Increased homocysteine levels are associated with increased risk of cardiovascular disease incidence and mortality in general population and with even greater risk in persons with diabetes mellitus. Among possible mechanisms of proatherogenic action of homocysteine increased procoagulant activity, increased oxidative stress and effect on proliferation of smooth muscle cells should be mentioned. However, the role of hyperhomocysteinemia in the development of microvascular complications is the subject of a few studies with controversial results. Some studies indicate the role of hyperhomocysteinemia in predicting micro- and macroalbuminuria and also retinopathy and neuropathy. Serum homocystine levels are dependent on age, renal function, and dietary intake of folic acid and B vitamins. The role of insulin in homocysteine metabolism is the subject of studies. Determination of the role of hyperhomocysteinemia in macrovascular and microvascular diabetes complications could be of importance in their prevention through dietary and pharmacological modifications of homocysteine levels.
Idzior-Waluś
B
B
Katedra Chorób Metabolicznych Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie.
Cieślik
G
G
D002318:Cardiovascular Diseases / Q000209:etiology*; D002908:Chronic Disease; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D006710:Homocysteine / Q000097:blood*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism; D012307:Risk Factors
D006710:Homocysteine