Neuroprotection and Angiogenesis: Dual Role of Erythropoietin in Brain Ischemia.
Erythropoietin, originally defined as an erythroid growth factor, is upregulated in the brain under conditions of hypoxia. So far, two functions have been identified for this locally produced cytokine: a direct protective effect on neuronal cells during cerebral ischemia and an indirect protection of brain tissue that could be provided by promoting brain vessel growth.
Marti
Hugo H.
HH
Max-Planck-Institut für Physiologische und Klinische Forschung, W. G. Kerckhoff-Institut, Abteilung Molekulare Zellbiologie, Parkstrasse 1, D-61231 Bad Nauheim, Germany.
Bernaudin
Myriam
M
Petit
Edwige
E
Bauer
Christian
C