title: Trichoblastoma of the skin occurring in the breast. A case report.
abstract: BACKGROUND
  Trichoblastoma is a rare benign skin appendage tumor constituted mostly of follicular germinative cells. It can arise on any part of the body except the palms, soles, nail units and mucosal membranes. No case of it in breast skin has been reported before. Furthermore, fine needle aspiration cytology findings on this lesion have not been described before.
  
  
  METHODS
  A 76-year-old female presented with a firm nodule in her left breast. The tumor was well demarcated, about 1.5 cm in diameter. Fine needle aspiration cytology revealed clusters composed of relatively uniform cells with a high nuclear/cytoplasmic ratio. In the midst of some clusters, the tumor cells had a more abundant cytoplasm. Fibrocellular interstitium or dense cyanophilic acellular material occasionally was attached to them. The tumor cells had oval or fusiform nuclei that had fine, evenly dispersed chromatin. To exclude a diagnosis of breast cancer, it is important to recognize that the clusters are composed of basaloid cells with focal squamous eddies and that there is at least focally peripheral palisading. The histopathologic diagnosis was trichoblastoma.
  
  
  CONCLUSIONS
  Fine needle aspiration cytology can distinguish trichoblastoma from malignant diseases of the breast and may be used to diagnose the lesion in conjunction with clinical findings.
authors.affiliation: Department of Laboratory Medicine and First Department of Surgery, National Defense Medical College Hospital, 3-2 Namiki, Tokorozawa, Saitama 359-8513, Japan. taka-emi@fj8.so-net.ne.jp
authors.forename: H
authors.initials: H
authors.lastname: Shimazaki
authors.forename: M
authors.initials: M
authors.lastname: Anzai
authors.forename: S
authors.initials: S
authors.lastname: Aida
authors.forename: H
authors.initials: H
authors.lastname: Endo
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: T
authors.initials: T
authors.lastname: Yamasaki
authors.forename: K
authors.initials: K
authors.lastname: Tamaki
authors.forename: S
authors.initials: S
authors.lastname: Tamai
mesh_terms: D000368:Aged; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology; D002280:Basal Cell Carcinoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis / Q000276:immunology; D018294:Neoplasms, Adnexal and Skin Appendage / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D012878:Skin Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*
chemical_list: D007633:Keratins