title: Acute myeloid leukemia with t(5;18)(q35;q21).
abstract: A case of acute myelocytic leukemia with a translocation (5;18)(q35;q21) is reported. Cytogenetic abnormalities of the long arm of chromosome 5 have long been known to affect hematopoiesis. Although translocations between 5q and other chromosomes have been associated with malignancy, this is the first reported case of a t(5;18) resulting in acute myeloid leukemia. Possible molecular mechanisms underlying the pathogenesis of the disease are discussed.
authors.affiliation: Leukemia Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center and Weill Medical College of Cornell University, 1275 York Avenue, New York, NY 10021, USA. wange@mskcc.org
authors.forename: E S
authors.initials: ES
authors.lastname: Wang
authors.forename: P
authors.initials: P
authors.lastname: Maslak
authors.forename: K
authors.initials: K
authors.lastname: Cathcart
authors.forename: J G
authors.initials: JG
authors.lastname: Jurcic
mesh_terms: D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D002871:Chromosome Banding; D002887:Chromosomes, Human, Pair 18 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014178:Translocation, Genetic