title: Cerebral white matter lesions and subjective cognitive dysfunction: the Rotterdam Scan Study.
abstract: OBJECTIVE
  To determine the relationship between cerebral white matter lesions (WML) and subjective cognitive dysfunction.
  
  
  BACKGROUND
  Subjective cognitive dysfunction is present when a person perceives failures of cognitive function. When annoying enough, these failures will be expressed as complaints. Subjective cognitive dysfunction may be a prelude to or coincide with objective cognitive impairment. WML have been related to objective cognitive impairment and dementia, but their relationship with subjective cognitive dysfunction is not clear. Previous population-based studies on the latter relationship have been limited in sample size, recording of subjective cognitive function, and assessment of WML severity.
  
  
  METHODS
  We randomly sampled 1,049 elderly nondemented participants from the general population. Data on subjective cognitive dysfunction and its progression were derived from a 15-item questionnaire. Objective cognitive performance was assessed using a series of neuropsychological tests. WML were scored on MRI for periventricular and subcortical regions separately.
  
  
  RESULTS
  WML were associated with more subjective cognitive failures. WML were more severe for participants reporting progression of these failures compared with participants without these failures, especially within participants with better than average cognitive performance (p = 0.008, for periventricular WML). Participants with severe WML reported progression of cognitive failures more than twice as often than did those with little or no WML. The relationship between the severity of WML and subjective cognitive failures was present for periventricular and subcortical WML.
  
  
  CONCLUSIONS
  WML are associated with subjective cognitive failures and in particular with reporting progression of these failures, even in the absence of objective cognitive impairment.
authors.affiliation: Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, The Netherlands. j.c.de.groot@rad.azg.nl
authors.forename: J C
authors.initials: JC
authors.lastname: de Groot
authors.forename: F E
authors.initials: FE
authors.lastname: de Leeuw
authors.forename: M
authors.initials: M
authors.lastname: Oudkerk
authors.forename: A
authors.initials: A
authors.lastname: Hofman
authors.forename: J
authors.initials: J
authors.lastname: Jolles
authors.forename: M M
authors.initials: MM
authors.lastname: Breteler
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D003072:Cognition Disorders / Q000453:epidemiology* / Q000473:pathology*; D015331:Cohort Studies; D003863:Depression / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology*; D009483:Neuropsychological Tests; D011897:Random Allocation; D018401:Sample Size; D011795:Surveys and Questionnaires