title: Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models.
abstract: Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.
authors.affiliation: Department of Neurological Surgery, University of Washington School of Medicine, 325 9th Ave., Seattle, WA 98104, USA.
authors.forename: Gerald A.
authors.initials: GA
authors.lastname: Grant
authors.forename: N. Joan
authors.initials: NJ
authors.lastname: Abbott
authors.forename: Damir
authors.initials: D
authors.lastname: Janigro