HLA-B allele frequencies in Côte d'Ivoire defined by direct DNA sequencing: identification of HLA-B*1405, B*4410, and B*5302.
Direct automated DNA sequencing was used to analyze exons 2 and 3 of HLA-B alleles present in forty-four unrelated individuals residing in the village of Adiopodoume, Côte d'Ivoire (Ivory Coast). Of the 23 HLA-B alleles observed, the most frequently detected allele was HLA-B*5301 (22.7%), which is believed to confer resistance to severe Plasmodium falciparum malaria. B*4501 (9.1%), B*1503 (8.0%), B*0705 (5.7%), B*1510 (5.7%) and B*3501 (5.7%) occurred frequently in the population. A second allele of B53 was identified; B*5302 contains a single amino acid variation at residue 171 (Y-->H). Two additional novel alleles, B* 1405 (a single amino acid variant of B*1402) and B*4410 (a five amino acid variant of B*4403) were characterized.
Ellis
J M
JM
Department of Microbiology and Immunology, Georgetown University Medical Center, Washington, DC, USA.
Hoyer
R J
RJ
Costello
C N
CN
Mshana
R N
RN
Quakyi
I A
IA
Mshana
M N
MN
Diaby
B
B
Traore
M
M
Johnson
A H
AH
Hurley
C K
CK
D000483:Alleles; D001483:Base Sequence; D007560:Cote d'Ivoire; D005787:Gene Frequency / Q000276:immunology*; D006680:HLA Antigens; D015235:HLA-B Antigens / Q000235:genetics*; D059909:HLA-B14 Antigen; D059948:HLA-B44 Antigen; D006801:Humans; D008969:Molecular Sequence Data; D017422:Sequence Analysis, DNA / Q000379:methods
D006680:HLA Antigens; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D059948:HLA-B44 Antigen; C078438:HLA-B53 antigen