title: Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: inhibitory role of C. albicans germination.
abstract: The role of Candida albicans yeast-to-hyphae transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production.
authors.affiliation: The Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio.
authors.forename: L
authors.initials: L
authors.lastname: Liu
authors.forename: K
authors.initials: K
authors.lastname: Kang
authors.forename: M
authors.initials: M
authors.lastname: Takahara
authors.forename: K D
authors.initials: KD
authors.lastname: Cooper
authors.forename: M A
authors.initials: MA
authors.lastname: Ghannoum
mesh_terms: D002176:Candida albicans / Q000276:immunology* / Q000302:isolation & purification / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis* / Q000235:genetics; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology
chemical_list: D018664:Interleukin-12