The Brix domain protein family -- a key to the ribosomal biogenesis pathway?
Six (one archaean and five eukaryotic) protein families have similar domain architecture that includes a central globular Brix domain, and optional N- and obligatory C-terminal segments, both with charged low-complexity regions. Biological data for some proteins in this superfamily suggest a role in ribosome biogenesis and rRNA binding.
Eisenhaber
F
F
Research Institute of Molecular Pathology, Dr.Bohr-Gasse 7, A-1030 Vienna, Rep. Austria. Frank.Eisenhaber@nt.imp.univie.ac.at
Wechselberger
C
C
Kreil
G
G
D000595:Amino Acid Sequence; D000818:Animals; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid