title: Scratch cytologic findings on surgically resected solitary fibrous tumors of the pleura.
abstract: OBJECTIVE
  To ascertain the cytologic characteristics of solitary fibrous tumors of the pleura (SFTPs) on smear preparations.
  
  
  METHODS
  Fine needle aspiration cytology (FNAC) was initially attempted preoperatively in five cases, but the specimens were inappropriate for interpretation because only a few tumor cells were obtained. Therefore, scratch smears made at the time of operation were used. Papanicolaou and immunocytochemical staining was performed in all 10 cases, 2 of which were malignant.
  
  
  RESULTS
  As expected, cellular tumors yielded more cells. The cytologic appearance was variable, showing spindle/bipolar, dendritic/stellate and intermediate cells. Atypical cells reminiscent of sarcoma were also present in cellular, benign tumors. Highly atypical epithelioid cells were obtained in two malignant cases. Immunocytochemically, the tumor cells were positive for CD34 and vimentin and negative for cytokeratin, regardless of histologic differences and cell shape.
  
  
  CONCLUSIONS
  It seems difficult to diagnose SFTPs with certainty by FNAC, partly because the cell morphology of SFTPs resembles a wide variety of heterogeneous groups of spindle cell tumors and partly because only a few tumor cells were available in the FNAC specimens in the present study. However, a cytologic diagnosis of SFTP is possible if cytologic preparations yield CD34-positive cells with spindle/bipolar or dendritic/stellate morphology.
authors.affiliation: Departments of Pathology and Surgery, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo 160-0023, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: Y
authors.initials: Y
authors.lastname: Ebihara
authors.forename: M
authors.initials: M
authors.lastname: Kudo
authors.forename: H
authors.initials: H
authors.lastname: Serizawa
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Otani
authors.forename: K
authors.initials: K
authors.lastname: Tsuji
mesh_terms: D000328:Adult; D000368:Aged; D018952:Antigens, CD34 / Q000032:analysis / Q000276:immunology; D002467:Cell Nucleus / Q000648:ultrastructure; D048429:Cell Size; D003581:Cytodiagnosis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D010997:Pleural Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*
chemical_list: D018952:Antigens, CD34