Cytokine secreted by rat macrophages and inhibiting proliferation of mesothelial cells.
Rat peritoneal macrophages and human peripheral blood monocytes secrete a protein with a molecular weight of 450 kDa, which specifically inhibits proliferation of cultured rat pleural mesothelial cells, but not fibroblasts and epitheliocytes. Protein secretion does not depend on the activation of macrophages. This cytokine is not a cobalamin-binding protein and has no arginase activity.
Furalev
V A
VA
Laboratory of Natural Cancerogens, Institute of Carcinogenesis, N. N. Blokhin Oncology Research Center, Russian Academy of Medical Sciences, Moscow, Russia.
Kravchenko
I V
IV
Vasil'eva
L A
LA
Pylev
L N
LN
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D017077:Culture Media, Conditioned / Q000737:chemistry; D016207:Cytokines / Q000378:metabolism / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism; D004847:Epithelial Cells / Q000187:drug effects*; D005347:Fibroblasts / Q000378:metabolism; D006098:Granulocytes / Q000378:metabolism; D006801:Humans; D017737:Macrophages, Peritoneal / Q000378:metabolism*; D009000:Monocytes / Q000378:metabolism; D022423:Myeloid Cells / Q000378:metabolism; D010994:Pleura / Q000166:cytology* / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D014805:Vitamin B 12 / Q000494:pharmacology
D017077:Culture Media, Conditioned; D016207:Cytokines; D004247:DNA; D014805:Vitamin B 12