title: Liver cell specific targeting of peptide nucleic acid oligomers.
abstract: Chimeric molecules consisting of peptide nucleic acid (PNA) and lactose have been synthesized to test the hypothesis that lactose moieties can promote cell-specific uptake of PNAs. We find that lactose modified PNAs rapidly enter liver-derived HepG2 cells while unmodified PNAs do not and that lactose modified PNAs can inhibit cellular telomerase.
authors.affiliation: Department of Pharmacology and Biochemistry, University of Texas Southwestern Medical Center at Dallas, 75390-9041, USA.
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: C G
authors.initials: CG
authors.lastname: Simmons
authors.forename: D R
authors.initials: DR
authors.lastname: Corey
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D007785:Lactose / Q000737:chemistry; D008099:Liver / Q000166:cytology* / Q000378:metabolism; D008856:Microscopy, Fluorescence; D009841:Oligonucleotides / Q000138:chemical synthesis / Q000494:pharmacology; D009928:Organ Specificity; D020135:Peptide Nucleic Acids / Q000138:chemical synthesis / Q000493:pharmacokinetics*; D012235:Rhodamines; D013329:Structure-Activity Relationship; D019098:Telomerase / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D009841:Oligonucleotides; D020135:Peptide Nucleic Acids; D012235:Rhodamines; D019098:Telomerase; D007785:Lactose