Fibrinogen: structure, function, and surface interactions.
Fibrinogen plays a central role in the mechanism of coagulation and thrombosis and is partially involved in the development of postintervention restenosis. Because of therapeutic implications, it is convenient for the vascular interventionalist to revisit its structure, function, and relationships within the vascular environment. This review focuses on the molecular structure, mechanisms of polymerization and lysis, and fibrinogen interaction with the platelet alpha(IIb)beta(3) [corrected] integrin. It also addresses the less understood interaction of fibrinogen with artificial surfaces. Glycoprotein IIb-IIIa blockers, targeted to interfere with fibrinogen-platelet interactions, widely used in clinical practice, are discussed, and trials of new drugs are also summarized.
Fuss
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Cardiovascular Research, Department of Radiology, The University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, Texas 78229-7800, USA. simonc@uthscsa.edu
Palmaz
J C
JC
Sprague
E A
EA
D005340:Fibrinogen / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D015394:Molecular Structure; D013501:Surface-Active Agents / Q000494:pharmacology*
D013501:Surface-Active Agents; D005340:Fibrinogen