Effects of new taurine derivatives on primary immune response in rats.
The effects of new taurine derivatives TAU-15 and TAU-60 with normal and branched alkyl chains, respectively, in a dose of 25 mg/kg on the primary immune response in rats were studied in rats. Intraperitoneal injections of test compounds for 24 days caused transient inhibition of immune reactions to thymus-dependent antigen, which was related to suppressed production of interleukin-1beta playing a key role in antigen presentation. This effect was probably associated with activation of cortisol secretion. TAU-15 inhibited production of tumor necrosis factor-alpha and, therefore, prevented tissue damages. The immune response was normalized after withdrawal of these preparations.
Sapronov
N S
NS
S. V. Anichkov Department of Neuropharmacology, Department of Immunology, Institute of Experimental Medicine, Russian Academy of Medical Sciences, St. Petersburg, Russia. sns@iem.spb.ru
Khnychenko
L K
LK
Polevshchikov
A V
AV
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000276:immunology*; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis*; D004912:Erythrocytes / Q000276:immunology; D006854:Hydrocortisone / Q000097:blood; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000097:blood; D007375:Interleukin-1 / Q000096:biosynthesis; D008297:Male; D051381:Rats; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013654:Taurine / Q000031:analogs & derivatives / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016207:Cytokines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D013654:Taurine; D006854:Hydrocortisone