Subacute clinical forms of Plasmodium falciparum malaria in travelers receiving chloroquine-proguanil prophylaxis.
We have observed 4 French travelers, returning from African countries, who were not immune to malaria and were receiving chloroquine-proguanil prophylaxis, in whom the diagnosis of malaria could easily have been missed because the clinical signs were uncommon. These cases suggest that chloroquine-proguanil prophylaxis is not always effective and that travelers with unexplained symptoms should be monitored closely for malaria.
Klement
E
E
Service des Maladies Infectieuses, Hôpital Pitié-Salpêtrière, Paris, France.
Chauveheid
M P
MP
Thellier
M
M
Bricaire
F
F
Danis
M
M
Caumes
E
E
D000328:Adult; D000349:Africa; D000368:Aged; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use*; D018890:Chemoprevention; D002738:Chloroquine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D016778:Malaria, Falciparum / Q000175:diagnosis / Q000517:prevention & control; D008297:Male; D010963:Plasmodium falciparum / Q000187:drug effects; D002727:Proguanil / Q000627:therapeutic use*; D014195:Travel
D000962:Antimalarials; D002738:Chloroquine; D002727:Proguanil