HLA-association in patients with intolerance to mercury and other metals in dental materials.
A group of selected 25 patients with serious intolerance to heavy metals used for dental restoration were examined for HLA antigens. A significant increase for HLA -- B37, B47 and DR4 was found. The value of the relative risk is not significant after correction for the number of antigens tested and therefore further studies of more patients are needed.
Procházková
J
J
Institute of Dental Research, Vinohradská 48, 120 60 Prague 2, Czech Republic. vuspraha@mbox.vol.cz
Bártová
J
J
Ivasková
E
E
Kupková
L
L
Sterzl
I
I
Stejskal
V D
VD
D000497:Alloys / Q000009:adverse effects; D003723:Dental Amalgam / Q000009:adverse effects; D003764:Dental Materials / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000453:epidemiology / Q000235:genetics*; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics*; D015235:HLA-B Antigens / Q000235:genetics; D059912:HLA-B37 Antigen; D015804:HLA-DR4 Antigen / Q000235:genetics; D006801:Humans; D008628:Mercury / Q000009:adverse effects*; D019216:Metals, Heavy / Q000009:adverse effects*; D012306:Risk
D000497:Alloys; D003764:Dental Materials; D006680:HLA Antigens; D015235:HLA-B Antigens; D059912:HLA-B37 Antigen; C106993:HLA-B47 antigen; D015804:HLA-DR4 Antigen; D019216:Metals, Heavy; D003723:Dental Amalgam; D008628:Mercury