title: Persistent tyrosinemia detected by thin-layer chromatography.
abstract: Screening for tyrosinemia is not routinely performed worldwide. Using a low expense thin-layer chromatography (TLC) for amino acids we detected a high frequency of transient tyrosinemia with secondary hyperphenylalaninemia in some newborns. Serum follow up showed the need to introduce adequate therapy in these babies.
authors.affiliation: Nobel RIE Laboratory, Neonatal Screening Center, Rurto Alegre, RS, Brazil.
authors.forename: E C
authors.initials: EC
authors.lastname: Neto
authors.forename: J
authors.initials: J
authors.lastname: Schulte
authors.forename: E
authors.initials: E
authors.lastname: Anele
authors.forename: D
authors.initials: D
authors.lastname: Becker
authors.forename: R
authors.initials: R
authors.lastname: Rubim
authors.forename: E
authors.initials: E
authors.lastname: Lewis
authors.forename: J
authors.initials: J
authors.lastname: De Mari
authors.forename: R
authors.initials: R
authors.lastname: Giugliani
mesh_terms: D002855:Chromatography, Thin Layer; D006801:Humans; D007231:Infant, Newborn; D015997:Neonatal Screening; D010649:Phenylalanine / Q000097:blood*; D014443:Tyrosine / Q000097:blood*; D020176:Tyrosinemias / Q000175:diagnosis* / Q000628:therapy
chemical_list: D014443:Tyrosine; D010649:Phenylalanine