title: Pleuropulmonary blastoma: an aggressive intrathoracic neoplasm of childhood.
abstract: A case of a 4-year-old girl with pleuropulmonary blastoma is reported. Surgical resection of the tumor was performed and histologic examination revealed pleuropulmonary blastoma with rhabdomyosarcomatous differentiation. Postoperative chemotherapy was administered and 3 weeks after initiation of treatment protocol a second site of lesion in the retroperitoneum was revealed with extension to the mediastinum, which shared similar mesenchymal neoplastic characteristics to the previously diagnosed primary lesion. The girl died 4 1/2 months after initial evidence of disease because of brain metastasis, indicating a very aggressive neoplasm unresponsive to treatment.
authors.affiliation: Department of Pediatric Hematology/Oncology, University Hospital of Heraklion, 71500 Crete, Greece.
authors.forename: C
authors.initials: C
authors.lastname: Perdikogianni
authors.forename: E
authors.initials: E
authors.lastname: Stiakaki
authors.forename: V
authors.initials: V
authors.lastname: Danilatou
authors.forename: G
authors.initials: G
authors.lastname: Delides
authors.forename: M
authors.initials: M
authors.lastname: Kalmanti
mesh_terms: D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D016609:Neoplasms, Second Primary / Q000175:diagnosis / Q000473:pathology; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy; D018202:Pulmonary Blastoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000628:therapy; D012208:Rhabdomyosarcoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology; D014057:Tomography, X-Ray Computed