Thrombolysis of extracranial and intracranial arteries after IV abciximab.
Abciximab was administered intravenously to three patients to treat thrombus associated with atherosclerotic stenosis of a supra-aortic artery. In two cases, the thrombi had been identified on a previous angiography more than a week before treatment. Successful thrombolysis was achieved with abciximab in all three cases. In this small series, abciximab had a thrombolytic effect on established thrombi that were refractory to previous antithrombotic treatment attempts.
Houdart
E
E
Department of Neuroradiology and Therapeutic Angiography, Hôpital Lariboisière, Paris, France. ehoudart@compuserve.com
Woimant
F
F
Chapot
R
R
Mounayer
C
C
Soria
C
C
Merland
J J
JJ
D000077284:Abciximab; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D000925:Anticoagulants / Q000008:administration & dosage*; D002533:Cerebral Angiography; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage*; D007275:Injections, Intravenous; D002537:Intracranial Arteriosclerosis / Q000175:diagnosis / Q000628:therapy; D020767:Intracranial Thrombosis / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D015912:Thrombolytic Therapy
D000911:Antibodies, Monoclonal; D000925:Anticoagulants; D007140:Immunoglobulin Fab Fragments; D000077284:Abciximab