title: [Cardioprotective effects of a new fluorine-containing synthetic activator of ATP-dependent potassium channels].
abstract: Effects of PF-10 the new fluorine-containing activator of ATP-dependent K-channels were investigated on the guinea-pig isolated heart. PF-10 enhanced myocardial contractility and decreased coronary vessels resistance in a dose-dependent manner. Low doses (10 mM/L, 1 mM/L) of PF-10 attenuates of the spontaneous alterations of heart rate, while high doses (0.1 mM/L) leds to these alterations. Previous activation of ATP-dependent K-channels by PF-10 has a cardioprotective effect during ischemia-reperfusion which a similar to the well-known phenomenon of ischemic preconditioning.
authors.affiliation: A.A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
authors.forename: R B
authors.initials: RB
authors.lastname: Strutyns'kyĭ
authors.forename: O O
authors.initials: OO
authors.lastname: Moĭbenko
authors.forename: L M
authors.initials: LM
authors.lastname: Iahupol's'kyĭ
authors.forename: M Ia
authors.initials: MIa
authors.lastname: Iuz'kiv
authors.forename: L I
authors.initials: LI
authors.lastname: Kvochina
authors.forename: A M
authors.initials: AM
authors.lastname: Shysh
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D019157:Ischemic Preconditioning, Myocardial; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D015221:Potassium Channels / Q000819:agonists* / Q000378:metabolism; D015427:Reperfusion Injury / Q000517:prevention & control*; D014655:Vascular Resistance / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D015221:Potassium Channels; D014665:Vasodilator Agents; D000255:Adenosine Triphosphate