Incidence and associations of acute renal failure complicating high-dose intravenous immunoglobulin therapy.
In a formal study, we have identified increasing age, pretreatment renal impairment and diabetes mellitus as risk factors for the development of intravenous immunoglobulin-induced renal failure. Identification of these characteristics in potential recipients should alert clinicians to the associated increased risk of this serious complication.
Sati
H I
HI
Department of Haematology, Aberdeen Royal Infirmary, and Aberdeen Blood Transfusion Centre, Aberdeen, UK.
Ahya
R
R
Watson
H G
HG
D058186:Acute Kidney Injury / Q000453:epidemiology / Q000209:etiology*; D000367:Age Factors; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000628:therapy; D016001:Confidence Intervals; D048909:Diabetes Complications; D006402:Hematologic Diseases / Q000150:complications / Q000628:therapy*; D006467:Hemophilia A / Q000150:complications / Q000628:therapy; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000009:adverse effects*; D015994:Incidence; D007674:Kidney Diseases / Q000150:complications; D016017:Odds Ratio; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications / Q000628:therapy; D011697:Purpura, Thrombotic Thrombocytopenic / Q000150:complications / Q000628:therapy; D012307:Risk Factors
D016756:Immunoglobulins, Intravenous