title: A case series: initial outcome of persons with multidrug-resistant tuberculosis after treatment with the WHO standard retreatment regimen in Ho Chi Minh City, Vietnam.
abstract: Few data address the outcomes of patients who have multidrug-resistant tuberculosis (MDR-TB), defined as resistance to at least isoniazid and rifampin, and who receive a standard World Health Organization (WHO) recommended retreatment regimen after relapse or failure with initial treatment. In this case series, we examined treatment outcomes of a convenience sample of 42 relapse or failure patients who had documented MDR-TB and who had received a standard WHO retreatment regimen (2SHRZE/1HRZE/5H3R3E3). One patient died of tuberculosis in the last month of treatment; the remaining 41 patients completed retreatment. Of the 42, 14 (33%) were sputum smear-negative on completion of therapy. The proportion of patients cured of MDR-TB with the WHO retreatment regimen was similar to historic outcomes when no chemotherapy for TB was given.
authors.affiliation: Pham Ngoc Thach Tuberculosis and Lung Diseases Center, Ho Chi Minh City, Vietnam.
authors.lastname: Lan NTN
authors.forename: M F
authors.initials: MF
authors.lastname: Lademarco
authors.forename: N J
authors.initials: NJ
authors.lastname: Binkin
authors.forename: L B
authors.initials: LB
authors.lastname: Tung
authors.forename: H T
authors.initials: HT
authors.lastname: Quy
authors.forename: N V
authors.initials: NV
authors.lastname: Cĵ
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000592:standards* / Q000627:therapeutic use*; D002985:Clinical Protocols / Q000592:standards*; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000592:standards* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D019233:Retreatment; D012293:Rifampin / Q000592:standards* / Q000627:therapeutic use*; D017211:Treatment Failure; D016896:Treatment Outcome; D018088:Tuberculosis, Multidrug-Resistant / Q000188:drug therapy* / Q000401:mortality*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000401:mortality*; D014744:Vietnam; D014944:World Health Organization
chemical_list: D000995:Antitubercular Agents; D007538:Isoniazid; D012293:Rifampin