Future research needs for the health assessment of 1,3-butadiene.
In recent years, several organizations have evaluated the health effects of 1,3-butadiene. Dissimilar conclusions about the carcinogenicity of 1,3-butadiene have been reached, due to differences in interpretation of the same data. Although 1,3-butadiene has been extensively studied, various uncertainties and data gaps remain which will require further clarification to reduce the uncertainties in future health assessments. This paper discusses future research needs respective of cancer and non-cancer effects that would be useful for future assessments as to how 1,3-butadiene affects health.
Koppikar
A M
AM
National Center for Environmental Assessment, Washington Office (8623D), Office of Research and Development, U.S. Environmental Protection Agency, 1200 Pennsylvania Ave. N.W., Washington, DC 20460, USA. koppikar.aparna@epa.gov
D000393:Air Pollutants / Q000633:toxicity; D000395:Air Pollutants, Occupational / Q000633:toxicity; D002070:Butadienes / Q000633:toxicity*; D004782:Environmental Health; D005260:Female; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced; D016273:Occupational Exposure; D012107:Research Design; D018570:Risk Assessment; D014481:United States; D014484:United States Environmental Protection Agency
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D002070:Butadienes; C031763:1,3-butadiene