Neuregulin and ErbB receptor signaling pathways in the nervous system.
The neuregulins are a complex family of factors that perform many functions during neural development. Recent experiments have shown that neuregulins promote neuronal migration and differentiation, and regulate the selective expression of neurotransmitter receptors in neurons and at the neuromuscular junction. They also regulate glial commitment, proliferation, survival and differentiation. At interneuronal synapses, neuregulin ErbB receptors associate with PDZ-domain proteins at postsynaptic densities where they can modulate synaptic plasticity. How this combinatorial network - comprising many neuregulin ligands that signal through distinct combinations of dimeric ErbB receptors - elicits its multitude of biological effects is beginning to be resolved.
Buonanno
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Section on Molecular Neurobiology, Building 49, Room 5A-38, National Institutes of Health, Bethesda, Maryland 20892-4480, USA. buonanno@helix.nih.gov
Fischbach
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D000595:Amino Acid Sequence; D000818:Animals; D066246:ErbB Receptors / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000502:physiology*; D020880:Neuregulins / Q000737:chemistry / Q000502:physiology*; D009469:Neuromuscular Junction / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D020033:Protein Isoforms / Q000737:chemistry / Q000502:physiology; D017434:Protein Structure, Tertiary; D015398:Signal Transduction / Q000502:physiology
D009419:Nerve Tissue Proteins; D020880:Neuregulins; D020033:Protein Isoforms; D066246:ErbB Receptors