title: Lung function 5 yr after lung volume reduction surgery for emphysema.
abstract: Current datum more than 2 yr after lung volume reduction surgery (LVRS) for emphysema is limited. This prospective study evaluates pre-LVRS baseline and 5-yr results in 26 symptomatic patients (mean age 67 +/- 6 yr) (mean +/- SD) who underwent bilateral, targeted upper lobe stapled LVRS using video-assisted thoracoscopy. Baseline forced expiratory volume in 1 s (FEV(1)) was 0.7 +/- 0.2 L (mean +/- SD), 29 +/- 10% predicted. Following LVRS, with none lost to follow-up, mortality due to respiratory failure at 0.5, 1, 2, 3, 4, and 5 yr was 4%, 4%, 19%, 31%, 46%, and 58%, respectively. Increase above baseline for FEV(1) > 200 ml and/or FVC > 400 ml at 1, 2, 3, 4, and 5 yr post-LVRS was noted in 73%, 46%, 35%, 27%, and 8% of all patients; decrease in dyspnea grade >/= 1 in 88%, 69%, 46%, 27%, and 15%; and elimination of initial oxygen dependence in 18 patients in 78%, 50%, 33%, 22%, and 0%, respectively. Expiratory airflow improved due to the increase in both lung elastic recoil and small airway intraluminal caliber. Five patients decreased FEV(1) 141 +/- 60 ml/yr and FVC 102 +/- 189 ml/yr over 3.8 +/- 1.2 yr post-LVRS, similar to their pre-LVRS rate of decline. In the 11 patients who survived 5 yr, at 0.5-1.0 yr post-LVRS peak increase in FEV(1) was 438 +/- 366 ml, with a decline of 149 +/- 157 ml the following year and 78 +/- 59 ml/yr over 4.0-4.5 yr. Bilateral LVRS provided palliative clinical and physiological improvement in 9 of 26 patients at 3 yr, 7 at 4 yr, and 2 at 5 yr.
authors.affiliation: Pulmonary Division, Department of Medicine, Lakewood Regional Medical Center, University of California, Los Angeles, California, USA. afgelb@msn.com
authors.forename: A F
authors.initials: AF
authors.lastname: Gelb
authors.forename: R J
authors.initials: RJ
authors.lastname: McKenna
authors.forename: M
authors.initials: M
authors.lastname: Brenner
authors.forename: J D
authors.initials: JD
authors.lastname: Epstein
authors.forename: N
authors.initials: N
authors.lastname: Zamel
mesh_terms: D000368:Aged; D005080:Exercise Test; D005500:Follow-Up Studies; D005541:Forced Expiratory Volume; D006801:Humans; D008170:Lung Compliance; D011013:Pneumonectomy; D011446:Prospective Studies; D011656:Pulmonary Emphysema / Q000503:physiopathology / Q000601:surgery*; D012123:Pulmonary Ventilation; D015656:Respiratory Mechanics; D020775:Thoracic Surgery, Video-Assisted; D014797:Vital Capacity