Epileptic manifestations induced by midazolam in the neonatal period.
Antiepileptic drugs may cause worsening of epilepsy by aggravating pre-existing seizures or by triggering new seizure types. There are several reports of adverse effects related to midazolam, but only a few authors reported epileptic manifestations. We report four newborns seen at the Neonatal Intensive Care Unit of our University Hospital, who developed seizures a few seconds after the administration of midazolam. It is difficult to identify the patients at risk, but it is important to be aware and recognize this situation.
Montenegro
M A
MA
Department of Neurology, Faculty of Medical Sciences, University of Campinas, Campinas, SP, Brazil.
Guerreiro
M M
MM
Caldas
J P
JP
Moura-Ribeiro
M V
MV
Guerreiro
C A
CA
D004827:Epilepsy / Q000139:chemically induced*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects*; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D008874:Midazolam / Q000009:adverse effects*
D006993:Hypnotics and Sedatives; D008874:Midazolam