title: [Antihypertensive therapy in patients with stroke].
abstract: Most patients with acute ischemic stroke do not need antihypertensive therapy, because the rapid lowering of blood pressure (BP) may reduce cerebral blood flow due to impaired cerebral autoregulation. In patients with severe hypertension, or associated with other complications (hemorrhagic transformation, myocardial infarction, renal failure or dissection of the aorta), antihypertensive therapy should be done cautiously. In chronic phase, the optimal BP level for the prevention of stroke recurrence remains unclear. The presence of the J-curve phenomenon is still controversial. The several large scale trials are now in progress to determine the optimal BP level for the secondary prevention in stroke patients.
authors.affiliation: Department of Neurology, Tokyo Metropolitan Geriatric Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Kanemaru
authors.forename: A
authors.initials: A
authors.lastname: Kanemaru
authors.forename: I
authors.initials: I
authors.lastname: Kuwajima
mesh_terms: D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001794:Blood Pressure; D002560:Cerebrovascular Circulation; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy*; D055502:Secondary Prevention; D020521:Stroke / Q000150:complications* / Q000503:physiopathology
chemical_list: D000959:Antihypertensive Agents