Intracellular distribution and regulation of calpains in the thyroid gland.
We studied the distribution of calpains in various subcellular thyrocyte fractions and evaluated the possibility for direct activation of calpain localized in the plasma membrane by thyrotropin. Direct activation of calpain bound to the plasma membrane did not underlie transduction of the thyrotropin signal to Ca(2+)-dependent proteinases.
Stroev
E A
EA
Department of Biochemistry, Ryazan' State Medical University.
Bulaeva
N N
NN
Kochukov
M Y
MY
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002154:Calpain / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002458:Cell Fractionation; D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D003374:Coumarins / Q000494:pharmacology; D007202:Indicators and Reagents / Q000494:pharmacology; D008297:Male; D051381:Rats; D013961:Thyroid Gland / Q000737:chemistry / Q000166:cytology / Q000378:metabolism*; D013972:Thyrotropin / Q000494:pharmacology
D003374:Coumarins; D007202:Indicators and Reagents; D013972:Thyrotropin; D002154:Calpain; C028743:7-amino-4-methylcoumarin; D002118:Calcium