[Status of interferon in genital infections].
The interferon status test characterizes the interferon (IFN) system function and the functional activity of IFN-producing cytokine cells. In contrast to the routine method, we used fetal calf (FCS) and autologous sera for evaluating the patients' leukocyte capacity to produce IFN-alpha and IFN-gamma. Blood samples from 30 women with genital infections caused by herpes simplex virus, cytomegalovirus, Chlamydia, and Ureaplasma were tested. Autologous sera of 40% patients inhibited and of 6.6% patients stimulated the production of IFN-gamma in comparison with FCS. All the data are statistically reliable. 20.3% autologous sera contained acid-labile IFN-alpha. These results can be used for more effective immunocorrective therapy.
Shcheglovitova
O N
ON
Maksianina
E V
EV
Rastegaeva
I N
IN
Fluer
F S
FS
D000818:Animals; D002417:Cattle; D005260:Female; D005831:Genital Diseases, Female / Q000276:immunology* / Q000382:microbiology; D006801:Humans; D016898:Interferon-alpha / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology
D016898:Interferon-alpha; D007371:Interferon-gamma