Oxygen Radicals as Messengers in Oxygen-Dependent Gene Expression.
Changes in ambient PO(2) need to be sensed to allow long-term adaptation of cellular functions via the regulation of gene activity. The generation of OH* from H(2)O(2) in an iron-dependent perinuclear Fenton reaction for triggering gene expression could be the key event in the O(2) signaling pathway.
Kietzmann
Thomas
T
Institut für Biochemie und Molekulare Zellbiologie, Humboldtallee 23, 37073 Göttingen, Germany.
Fandrey
Joachim
J
Acker
Helmut
H