The sesquiterpene lactone dehydroleucodine reversibly inhibits Allium cepa L. root growth.
Here, we prove that dehydroleucodine, a sesquiterpene lactone, at low concentrations (25-100 microM) slowed down the Allium cepa L root growth by 22-70% respectively neither affecting cell viability nor cell size. Removal of the drug after 24 h incubation restored the normal growth rate of the roots. Higher concentrations (200 microM) of dehydroleucodine were deleterious for the roots. As cell size did not change, it is most likely that dehydroleucodine affected some event of cell division cycle making it longer. Thus, dehydroleucodine could be a useful tool to slow down cell proliferation.
Sartor
T
T
Instituto de Histología y Embriología, Facultad de Ciencias Médicas U.N. Cuyo Mendoza Argentina.
Elis Lopez
M
M
Gutierrez
L
L
Guerreiro
E
E
Giordano
O S
OS
López
L A
LA
D048429:Cell Size; D002470:Cell Survival / Q000187:drug effects; D007783:Lactones / Q000494:pharmacology*; D019697:Onions / Q000187:drug effects* / Q000254:growth & development; D018517:Plant Roots / Q000166:cytology / Q000187:drug effects* / Q000254:growth & development; D012717:Sesquiterpenes / Q000494:pharmacology*
D007783:Lactones; D012717:Sesquiterpenes; C079949:dehydroleucodine