[Hormone dysregulators. Pseudo-estrogens in dental composite resins and sealanta?].
A number of polluting chemicals in the ecosystems must be characterized as hormone disruptors. Among others, male animals appear to become feminized by the action of the so-called pseudo-estrogens and under their influence mens' fertility is said to decrease. Composites and sealants based on Bis-GMA resin may contain bisphenol-A as an impurity and Bis-DMA, from which in saliva bisphenol-A will be formed by hydrolytic degradation. Therefore, in extreme circumstances a weak estrogenic effect is not impossible on the short-term. However, the amounts of these probably not very potent estrogenic compounds are small, thereby resulting in a tolerable risk on the short term. Long-term-effects and synergism with pseudo-estrogens from other sources prompt further studies in order to verify the safety of the Bis-GMA containing products.
Schuurs
A H
AH
Afdeling Cariologie Endodontologie Pedodontologie, Academisch Centrum Tandheelkunde Amsterdam (ACTA).
Moorer
W R
WR
D017438:Bisphenol A-Glycidyl Methacrylate / Q000009:adverse effects / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D003188:Composite Resins / Q000009:adverse effects* / Q000737:chemistry; D004968:Estrogens, Non-Steroidal / Q000009:adverse effects / Q000138:chemical synthesis*; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D010895:Pit and Fissure Sealants / Q000009:adverse effects* / Q000737:chemistry; D012306:Risk
D003188:Composite Resins; D004968:Estrogens, Non-Steroidal; D010895:Pit and Fissure Sealants; D017438:Bisphenol A-Glycidyl Methacrylate