[Cell activation in the hypothalamus after exposure to an antigen (based on c-fos gene expression)].
Increase of the c-fos mRNA positive cells number was insignificant in 30 min. following activation of the rat hypothalamic structures with the tetanus toxoid (TT). Elevation of the c-fos mRNA positive cells number occurred in the hypothalamic' posterior (PHA), lateral (LHA), anterior (AHA), areas dorsomedial (DMH), and ventromedial (VMH) nuclei within 2 hours of the TT administration. In 6 hours the c-fos mRNA positive cells number decreased in PHA, LHA, DMH. The c-fos mRNA expression was stable in arquate and supraoptic hypothalamic nuclei following either the TT or saline administration.
Nosov
M A
MA
Institute of Experimental Medicine, Russian Acad. Med. Sci, 197376, St. Petersburg, Acad. I. P. Pavlov St., 12.
Barabanova
S V
SV
Glushikhina
M S
MS
Kazakova
T B
TB
Korneva
E A
EA
D000818:Animals; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D015213:Neuroimmunomodulation; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013745:Tetanus Toxoid / Q000494:pharmacology*; D013997:Time Factors
D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D013745:Tetanus Toxoid