title: Knee joint arthroplasty in a patient with haemophilia A and high inhibitor titre using recombinant factor VIIa (NovoSeven): a new case report and review of the literature.
abstract: Elective orthopaedic surgery is regularly withheld from patients with haemophilia and high inhibitor titre despite the presence of severe arthropathy and urgent medical need. A knee joint arthroplasty was performed in a patient with severe haemophilia A and a high inhibitor titre using recombinant factor VIIa (rFVIIa) as the sole coagulation factor. There was no abnormal bleeding during surgery although an increased blood loss through surgical drains did occur during the first 6 h postoperatively. Rehabilitation was started on day 1 and continued for 3 months. Walking commenced on day 4. After 1 year of follow-up, the clinical outcome of surgery was considered excellent with no pain, knee mobility at 0-5-90 degrees, and an International Knee Society score of 95/100. No rFVIIa-associated side-effects or thrombotic complications were reported. In conclusion, knee joint arthroplasty is now an option for haemophilia patients with a high inhibitor titre. An international review of all available data on elective orthopaedic surgery in inhibitor patients is required so that the optimal treatment regime can be defined and the short- and long-term risk-benefit ratio of surgery compared to that of noninhibitor patients.
authors.affiliation: Haemophilia Regional Centre, University Hospital Hautepierre, Strasbourg, France. albert.faradji@chru-strasbourg.fr
authors.forename: A
authors.initials: A
authors.lastname: Faradji
authors.forename: F
authors.initials: F
authors.lastname: Bonnomet
authors.forename: J
authors.initials: J
authors.lastname: Lecocq
authors.forename: L
authors.initials: L
authors.lastname: Grunebaum
authors.forename: D
authors.initials: D
authors.lastname: Desprez
authors.forename: O
authors.initials: O
authors.lastname: Kern
authors.forename: L
authors.initials: L
authors.lastname: Barbier
authors.forename: J
authors.initials: J
authors.lastname: Sibilia
mesh_terms: D000328:Adult; D019645:Arthroplasty, Replacement, Knee / Q000534:rehabilitation*; D016063:Blood Loss, Surgical / Q000517:prevention & control; D015942:Factor VIIa / Q000008:administration & dosage*; D006467:Hemophilia A / Q000188:drug therapy / Q000276:immunology / Q000601:surgery*; D006801:Humans; D007518:Isoantibodies / Q000097:blood; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage
chemical_list: D007518:Isoantibodies; D011994:Recombinant Proteins; D015942:Factor VIIa