title: Diterpenes from the bark and seeds of Colophospermum mopane.
abstract: The CHCl3 extract of the bark and seeds of Colophospermum mopane gave three new diterpenes, dihydrogrindelic acid and dihydrogrindelaldehyde and methyl labd-13E-en-15-oate. The structures were assigned on the basis of detailed spectroscopic data analyses. The aldehyde showed significant cytotoxic activity against a human breast cancer cell line.
authors.affiliation: epartment of Chemistry, University of Zimbabwe, Mount Pleasant, Harare. mebe@compcentre.uz.ac.zw
authors.forename: P P
authors.initials: PP
authors.lastname: Mebe
mesh_terms: D000447:Aldehydes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D002460:Cell Line / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D019685:Rosales / Q000145:classification*; D012639:Seeds / Q000737:chemistry; D013019:South Africa; D014197:Trees
chemical_list: D000447:Aldehydes; D000970:Antineoplastic Agents; D004224:Diterpenes; C438047:dihydrogrindelaldehyde