title: Survival and outcome after hepatic artery thrombosis complicating pediatric liver transplantation.
abstract: OBJECTIVE
  Hepatic artery thrombosis (HAT) represents a significant cause of graft loss and mortality after pediatric orthotopic liver transplantation (OLT). The incidence and etiology of this complication have been investigated in detail but relatively little is known about outcome.
  
  
  METHODS
  A review was conducted of all children with confirmed HAT complicating OLT during a 10-year period (1990 through 1999) in a single center. HAT was established by angiography or at operation in all cases.
  
  
  RESULTS
  From a consecutive series of 400 pediatric OLTs, there were 31 (7.8%) instances of HAT in 29 children of median age 3.8 years (range, 8 days to 16 years). Twenty-four (83%) are alive after a median follow-up of 3.6 years. Fourteen cases occurred after transplantation of whole grafts and 17 after reduced or split livers. Of the 18 episodes resulting in retransplantation, there were 5 deaths and 2 second episodes of HAT; surviving children are alive with good graft function. Of the 13 episodes managed without retransplantation, 4 patients underwent attempted early revascularisation of the graft, which was successful in 2, and the remainder initially were treated conservatively. All 13 children are alive after a median follow-up of 4.1 years (range, 0.6 to 5.8), but 5 required radiologic or surgical intervention for biliary or septic complications; biochemical liver function is normal in 8, mildly abnormal in 3, and poor in 2. Retransplantation was less likely in those who had received reduced or split grafts (7 of 17) compared with those who had received whole grafts (11 of 14), but this difference just failed to reach statistical significance (chi(2) = 3.01, 0.1 > P > .05).
  
  
  CONCLUSIONS
  Using a selective policy of retransplantation, revascularisation, and conservative treatment, 83% of children survived HAT complicating OLT. Approximately 40% of children with HAT survived without retransplantation. J Pediatr Surg 36:888-891.
authors.affiliation: Liver Transplantation Surgical Service, Paediatric Liver Service, and Department of Radiology, King's College Hospital, London, England.
authors.forename: M D
authors.initials: MD
authors.lastname: Stringer
authors.forename: M M
authors.initials: MM
authors.lastname: Marshall
authors.forename: P
authors.initials: P
authors.lastname: Muiesan
authors.forename: J B
authors.initials: JB
authors.lastname: Karani
authors.forename: P A
authors.initials: PA
authors.lastname: Kane
authors.forename: G
authors.initials: G
authors.lastname: Mieli-Vergani
authors.forename: M
authors.initials: M
authors.lastname: Rela
authors.forename: N D
authors.initials: ND
authors.lastname: Heaton
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016031:Liver Transplantation; D008131:London / Q000453:epidemiology; D008297:Male; D011183:Postoperative Complications / Q000401:mortality / Q000601:surgery*; D012086:Reoperation; D012189:Retrospective Studies; D015996:Survival Rate; D013927:Thrombosis / Q000401:mortality / Q000601:surgery*; D016896:Treatment Outcome