title: The role of tissue plasminogen activator in the successful treatment of infected cardiac thrombus in children.
abstract: Infected cardiac thrombus is rare in children, with antibiotic or antifungal agents used as the first line of treatment. Persistence is an indication for surgical intervention. We describe two children who were treated successfully with a combination of antibiotic and antithrombotic agents. Use of antithrombotic agents promotes degeneration of fibrin, thus reducing the mass and facilitating the diffusion of the antibiotic and/or antifungal agents.
authors.affiliation: Cardiology Department, Soroka University Medical Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel. eliz@bgumail.bgu.ac.il
authors.forename: E
authors.initials: E
authors.lastname: Zalzstein
authors.forename: N
authors.initials: N
authors.lastname: Zucker
authors.forename: A
authors.initials: A
authors.lastname: Levitas
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D002669:Child Welfare; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006331:Heart Diseases / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D007239:Infections / Q000188:drug therapy*; D013927:Thrombosis / Q000188:drug therapy* / Q000382:microbiology; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005343:Fibrinolytic Agents; D010959:Tissue Plasminogen Activator