Skeletal and cardiac muscle contractile activation: tropomyosin "rocks and rolls".
Changes in thin filament structure induced by Ca(2+) binding to troponin and subsequent strong cross-bridge binding regulate additional strong cross-bridge attachment, force development, and dependence of force on sarcomere length in skeletal and cardiac muscle. Variations in activation properties account for functional differences between these muscle types.
Gordon
A M
AM
Department of Physiology and Biophysics, University of Washington, Seattle, WA, USA.
Regnier
M
M
Homsher
E
E
D008841:Actin Cytoskeleton / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D009119:Muscle Contraction / Q000502:physiology*; D018482:Muscle, Skeletal / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology*; D014335:Tropomyosin / Q000378:metabolism*
D014335:Tropomyosin; D002118:Calcium