Enantio- and diastereoselective reductive aldol reactions with iridium-pybox catalysts.
[see reaction]. A catalytic amount of [(cod)IrCl]2 and indane-pybox converts diethylmethylsilane, methyl acrylate, and certain aldehydes to the derived reductive aldol adduct with good enantio- and diastereocontrol.
Zhao
C X
CX
Department of Chemistry, Venable and Kenan Laboratories, The University of North Carolina at Chapel Hill, Chapel Hill, North Carolina 27599-3290, USA.
Duffey
M O
MO
Taylor
S J
SJ
Morken
J P
JP