Propagation of Cell Death During Myocardial Reperfusion.
During myocardial reperfusion, increased cytosolic Ca(2+) concentration may cause hypercontracture and cell death. Hypercontracture can propagate to adjacent cells by a gap junction-dependent mechanism. This propagation explains infarct geometry and increases the final extent of necrosis. Its prevention may represent a new therapeutic strategy for treating patients with myocardial infarction.
Garcia-Dorado
David
D
Servicio de Cardiología, Hospital General Universitari Vall d'Hebron, Pg Vall d'Hebron 119-129, 08035 Barcelona, Spain.
Ruiz-Meana
Marisol
M