title: A thioester ligation approach to amphipathic bicyclic peptide library.
abstract: An efficient approach to synthesize an amphipathic bicyclic peptide library from unprotected peptides is demonstrated through an on-resin intramolecular thioester ligation and an off-resin DMSO-mediated disulfide formation.
authors.affiliation: Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: G
authors.initials: G
authors.lastname: Lu
authors.forename: J P
authors.initials: JP
authors.lastname: Tam
mesh_terms: D000595:Amino Acid Sequence; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis*; D013438:Sulfhydryl Compounds / Q000737:chemistry
chemical_list: D001643:Bridged Bicyclo Compounds; D019151:Peptide Library; D010455:Peptides; D013438:Sulfhydryl Compounds