Synthesis and antitumor activity of some new phthalimide analogues.
The reactive intermediate 1-(chloroalkyl)-1-aza-2-azoniaallene salts 3, which were prepared by treatment of the alpha,alpha'-dichloroazo derivatives 2 with SbCl5, underwent cycloaddition with the N-cyanoalkyl phthalimide compounds 4 and afforded the 1,2,4-triazolium salts 5. These salts rearranged spontaneously to the protonated 1,2,4-triazoles 6, followed by hydrolysis in situ to the 1,2,4-triazolo-alkyl-phthalimide compounds 7. The newly synthesized compounds were then evaluated for their antitumor activity in three cell lines.
al-Soud
Y A
YA
College of Science, Department of Chemistry, University of Al al-Bayt, Al-Mafraq, Jordan.
al-Masoudi
N A
NA
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D003500:Cyclization; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D010797:Phthalimides / Q000138:chemical synthesis* / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D010797:Phthalimides