title: In vitro studies of the efficacy of antimicrobials against fungi.
abstract: OBJECTIVE
  The purpose of this study was to compare the efficacy of Listerine Antiseptic, Tartar Control Listerine Antiseptic, and Peridex mouthrinses and a 0.2% chlorhexidine digluconate solution against known pathogenic fungi.
  
  
  METHODS
  Standardized methods were used to compare the antimicrobial efficacy of the above agents versus representative fungal species. Minimum inhibitory concentration-minimum fungicidal concentrations in macrobroth dilutions, suspension kill-time, and effectiveness against an artificial biofilm-attached population were studied.
  
  
  RESULTS
  All antimicrobials tested were effective against the fungal species under investigation at the concentration available commercially. Listerine Antiseptic showed a greater efficacy against attached artificial biofilm populations than the other antimicrobials tested.
  
  
  CONCLUSIONS
  Listerine Antiseptic, Tartar Control Listerine Antiseptic, and Peridex mouthrinses show promise as a means to control the pathogenic fungal species under investigation and may have applications to reduce oral colonization.
authors.affiliation: Department of Oral Medicine and Diagnostic Sciences, Unversity of Maryland Dental School, Balitmore, Md 21201, USA. TFM001@dental.umaryland.edu
authors.forename: T F
authors.initials: TF
authors.lastname: Meiller
authors.forename: J I
authors.initials: JI
authors.lastname: Kelley
authors.forename: M A
authors.initials: MA
authors.lastname: Jabra-Rizk
authors.forename: L G
authors.initials: LG
authors.lastname: Depaola
authors.forename: A A
authors.initials: AA
authors.lastname: Baqui
authors.forename: W A
authors.initials: WA
authors.lastname: Falkler
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D002175:Candida / Q000145:classification / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology; D009067:Mouthwashes / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012459:Salicylates / Q000494:pharmacology; D013170:Spores / Q000187:drug effects; D013223:Statistics as Topic; D013729:Terpenes / Q000494:pharmacology; D013997:Time Factors
chemical_list: D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009067:Mouthwashes; D012459:Salicylates; D013729:Terpenes; C057473:Listerine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine