Distinguishing malignant from normal oral tissues using FTIR fiber-optic techniques.
Oral tissue samples were studied using mid-IR fiber-optic attenuated total reflectance spectroscopy and other spectral techniques. The 1745 cm(-1) band, which is assigned to the ester group (C==O) vibration of triglycerides, is a reliable marker that is present in normal tissues but absent or a weak band in malignant oral tissues. Other bands such as C--H stretching bands and the amide bands are also helpful in distinguishing malignant tissues from normal tissues. Subtraction spectra confirmed the above conclusion. In addition, Raman spectroscopic measurements were in agreement with the results observed from FTIR spectra.
Wu
J G
JG
Department of Chemistry, Medical School of Stomatology, Peking University, Beijing 100871, China. wjg@chemms.pku.edu.cn
Xu
Y Z
YZ
Sun
C W
CW
Soloway
R D
RD
Xu
D F
DF
Wu
Q G
QG
Sun
K H
KH
Weng
S F
SF
Xu
G X
GX
D014408:Biomarkers, Tumor / Q000737:chemistry; D005227:Fatty Acids / Q000737:chemistry; D005336:Fiber Optic Technology; D006801:Humans; D009062:Mouth Neoplasms / Q000175:diagnosis* / Q000473:pathology; D055100:Optical Fibers; D017550:Spectroscopy, Fourier Transform Infrared / Q000295:instrumentation / Q000379:methods
D014408:Biomarkers, Tumor; D005227:Fatty Acids