[nm23-H1 protein expression and its clinical significance in human laryngeal carcinoma].
The Objective of the study on the expression of nm23-H1 protein in human laryngeal carcinoma, was to explore the role of nm23 gene in lymph node metastasis and invasion. The expression of nm23-H1 protein was immunohistochemically examined in 86 resected human laryngeal carcinomas. Anti-nm23-H1 monoclonal antibody was used. The results showed that 66.3%(57/86) of the cases were positive for nm23-H1 protein expression in the primary lesions. The positive staining rate (90.5%, 38/42) of the patients without regional lymph node metastasis, was significantly higher than that of patients with nodal involvement (43.2%, 19/44). Inverse relationship were found between the nm23-H1 protein expression in the primary lesions and the depth of tumor invasion or the advance of clinical stage. Expression of nm23-H1 protein was positively associated with the ascending histological grade of the lesion, and the relationship was significant. The above data suggest that nm23 gene plays an important role in the control of lymph node metastasis and invasion in laryngeal carcinomas.
Liang
C
C
Department of Otorhinolaryngology, First Affiliated Hospital, WCUMS, Chengdu 610041.
Xu
G
G
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D006801:Humans; D007822:Laryngeal Neoplasms / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis / Q000235:genetics; D008297:Male; D008875:Middle Aged; D020559:Monomeric GTP-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D054778:NM23 Nucleoside Diphosphate Kinases; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009701:Nucleoside-Diphosphate Kinase; D011897:Random Allocation; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics
D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins