title: Detection of coronary artery stenoses by contrast-enhanced, retrospectively electrocardiographically-gated, multislice spiral computed tomography.
abstract: BACKGROUND
  Multislice spiral computed tomography (MSCT) with retrospectively ECG-gated image reconstruction permits coronary artery visualization. We investigated the method's ability to identify high-grade coronary artery stenoses and occlusions.
  
  
  RESULTS
  A total of 64 consecutive patients were studied by MSCT (4x1 mm cross-sections, 500-ms rotation, table feed 1.5 mm/rotation, intravenous contrast agent, retrospectively ECG-gated image reconstruction). All coronary arteries and side branches with a luminal diameter >/=2.0 mm were assessed concerning evaluability and the presence of high-grade stenoses (>70% diameter stenosis) or occlusions. Results were compared with quantitative coronary angiography. Of 256 coronary arteries (left main, left anterior descending, left circumflex and right coronary artery, including their respective side branches), 174 could be evaluated (68%). In 19 patients (30%), all arteries were evaluable. Artifacts caused by coronary motion were the most frequent reason for unevaluable arteries. Overall, 32 of 58 high-grade stenoses and occlusions were detected by MSCT (58%). In evaluable arteries, 32 of 35 lesions were detected, and the absence of stenosis was correctly identified in 117 of 139 arteries (sensitivity, 91%; specificity, 84%). If analysis was extended to all stenoses with >50% diameter reduction, sensitivity was 85% (40 of 47) and specificity was 76% (96 of 127).
  
  
  CONCLUSIONS
  MSCT with retrospective ECG gating permits the detection of coronary artery stenoses with high accuracy if image quality is sufficient, but its clinical use may presently be limited due to degraded image quality in a substantial number of cases, mainly due to rapid coronary motion.
authors.affiliation: Department of Internal Medicine II, Institute of Medical Physics, University of Erlangen-Nürnberg, Germany. stephan.achenbach@rzmail.uni-erlangen.de
authors.forename: S
authors.initials: S
authors.lastname: Achenbach
authors.forename: T
authors.initials: T
authors.lastname: Giesler
authors.forename: D
authors.initials: D
authors.lastname: Ropers
authors.forename: S
authors.initials: S
authors.lastname: Ulzheimer
authors.forename: H
authors.initials: H
authors.lastname: Derlien
authors.forename: C
authors.initials: C
authors.lastname: Schulte
authors.forename: E
authors.initials: E
authors.lastname: Wenkel
authors.forename: W
authors.initials: W
authors.lastname: Moshage
authors.forename: W
authors.initials: W
authors.lastname: Bautz
authors.forename: W G
authors.initials: WG
authors.lastname: Daniel
authors.forename: W A
authors.initials: WA
authors.lastname: Kalender
authors.forename: U
authors.initials: U
authors.lastname: Baum
mesh_terms: D000368:Aged; D003287:Contrast Media / Q000008:administration & dosage; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011856:Radiographic Image Enhancement; D014057:Tomography, X-Ray Computed / Q000379:methods*
chemical_list: D003287:Contrast Media