Synthesis of new cationic lipids from an unsaturated glycoside scaffold.
[see structure]. We report the synthesis of new cationic lipids. These amphiphiles present a hydrophobic domain connected to a guanidinium entity by an unsaturated glycoside scaffold. The synthetic strategy using amide or acetal linkage led to various mono- and bicatenar derivatives. Investigation of their physicochemical properties indicated that these new compounds compact DNA.
Herscovici
J
J
LCBBMC UMR 7001 CNRS-ENSCP-Aventis Gencell. ENSCP 11, rue Pierre et Marie Curie 75231 Paris Cedex France. herscovi@ext.jussieu.fr
Egron
M J
MJ
Quenot
A
A
Leclercq
F
F
Leforestier
N
N
Mignet
N
N
Wetzer
B
B
Scherman
D
D
D002412:Cations; D004247:DNA / Q000737:chemistry; D006027:Glycosides / Q000737:chemistry*; D008055:Lipids / Q000138:chemical synthesis*; D008968:Molecular Conformation
D002412:Cations; D006027:Glycosides; D008055:Lipids; D004247:DNA