title: Quality of life before and after laparoscopic Nissen fundoplication.
abstract: BACKGROUND
  Gastroesophageal reflux disease (GERD) is a common disorder in the Western world. The acute disease can usually be managed by medical therapy. To prevent relapse, many patients require lifelong medication. In these patients, laparoscopic antireflux surgery offers a good alternative. The aim of this study was to evaluate the postoperative results and compare pre- and postoperative quality of life after laparoscopic Nissen fundoplication.
  
  
  METHODS
  Clinical investigations, including esophageal manometry, pH monitoring, and endoscopy, and a previously validated Quality of Life Index, were performed before and a median of 41 month after antireflux surgery in 75 patients.
  
  
  RESULTS
  After laparoscopic Nissen fundoplication, the percentage of total time with pH <4 decreased from 10.4% to 3.2% on 24-h pH monitoring. The mean pressure of the lower esophageal sphincter improved from 8.1 to 12.3 mmHg. Esophagitis healed in 63 of 66 patients in whom it was present prior to surgery. The overall Quality of Life Index improved significantly from 86 +/- 16 to 116 +/- 16.
  
  
  CONCLUSIONS
  Laparoscopic fundoplication provides effective and durable relief of reflux in patients with GERD. The Quality of Life Index showed significant improvement after surgery.
authors.affiliation: Department of Surgery, Klinikum rechts der Isar der TU München, Ismaningerstrasse 22, 81675 München, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Möbius
authors.forename: H J
authors.initials: HJ
authors.lastname: Stein
authors.forename: M
authors.initials: M
authors.lastname: Feith
authors.forename: H
authors.initials: H
authors.lastname: Feussner
authors.forename: J R
authors.initials: JR
authors.lastname: Siewert
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D018662:Fundoplication / Q000379:methods*; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000523:psychology / Q000601:surgery*; D006304:Health Status; D006801:Humans; D010535:Laparoscopy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011788:Quality of Life; D016896:Treatment Outcome