title: Early breaking strength of repaired flexor tendon treated with 5-fluorouracil.
abstract: This study investigated the effect of a single intraoperative application of 5-fluorouracil, which may diminish peritendinous adhesion formation, on the tensile strength of repaired digital flexor tendons after 7, 14 and 21 days of healing. Twenty-seven deep flexor tendons from 14 rabbits were exposed to 5-fluorouracil (50 mg/ml) for 5 minutes immediately after repair whereas matched control tendons were exposed to normal saline. Tensile testing at 7, 14 and 21 days revealed no significant differences in the gap or ultimate strengths of the 5-fluorouracil treated and control tendons.
authors.affiliation: Department of Plastic and Reconstructive Surgery, University College London, London, UK. scerovac@aol.com
authors.forename: S
authors.initials: S
authors.lastname: Cerovac
authors.forename: A
authors.initials: A
authors.lastname: Afoke
authors.forename: A
authors.initials: A
authors.lastname: Akali
authors.forename: D A
authors.initials: DA
authors.lastname: McGROUTHER
mesh_terms: D000818:Animals; D005472:Fluorouracil / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D013537:Sutures; D013708:Tendon Injuries / Q000503:physiopathology / Q000601:surgery*; D013718:Tensile Strength; D000267:Tissue Adhesions / Q000503:physiopathology; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D005472:Fluorouracil