title: [Challenging perioperative anticoagulation in a patient with Budd-Chiari syndrome and heparin-induced thrombocytopenia].
abstract: We report on a patient suffering from Budd-Chiari disease who developed heparin-induced thrombocytopenia preoperatively. Dorsocranial liver resection and hepatoatrial anastomosis were performed with the extracorporeal circulation and perioperative anticoagulation was achieved with r-hirudin. Surprisingly, thrombus formation was observed in the venous reservoir although intraoperative anticoagulation values were within the targeted level. An additional bolus of hirudin and rinsing the reservoir allowed unproblematic discontinuation of the cardiopulmonary bypass.
authors.affiliation: Universitätsklinik für Herz- und Gefässchirurgie, Inselspital Bern.
authors.forename: E
authors.initials: E
authors.lastname: Gygax
authors.forename: P
authors.initials: P
authors.lastname: Berdat
authors.forename: T
authors.initials: T
authors.lastname: Carrel
mesh_terms: D000328:Adult; D006502:Budd-Chiari Syndrome / Q000097:blood / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D005112:Extracorporeal Circulation; D006325:Heart Atria / Q000601:surgery; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006503:Hepatic Veins / Q000601:surgery; D006629:Hirudins / Q000008:administration & dosage*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D010314:Partial Thromboplastin Time; D012008:Recurrence; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced*; D020246:Venous Thrombosis / Q000188:drug therapy
chemical_list: D006629:Hirudins; D006493:Heparin