Allogeneic haematopoietic stem cell transplantation with reduced intensity conditioning regimens ("minitransplants").
During the recent years it became evident that allogeneic haematopoietic stem cell transplantation with reduced intensity conditioning is feasible. Though less toxic than conventional stem cell grafting severe adverse effects have been reported and are not uncommon. Due to the still short observation periods realistic outcome estimations cannot be made yet. Nevertheless allografting with reduced intensity conditioning is a promising new therapeutic option and hopefully its true position in the treatment of haematologic and oncologic diseases will become more clear in the next future.
Schanz
U
U
Division of Haematology, Department of Internal Medicine, University Hospital Zurich, Switzerland. urs.schanz@dim.usz.ch
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D005240:Feasibility Studies; D006086:Graft vs Host Disease / Q000209:etiology / Q000517:prevention & control*; D006402:Hematologic Diseases / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D009369:Neoplasms / Q000628:therapy*; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents