title: Efficient syntheses of novel C2'-alkylated (+/-)-K252a analogues.
abstract: Recent efforts in our laboratories have resulted in a synthetic approach toward C2'-alkylated K252a analogues via extension of a K252a cyclofuranosylation strategy. The bis-indole-N-glycosidic coupling of 6-N-(3,4-dimethoxybenzyl)-staurosporinone (21) with a number of highly functionalized carbohydrates has given access to previously unattainable, biologically relevant analogues.
authors.affiliation: Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
authors.forename: K
authors.initials: K
authors.lastname: Tamaki
authors.forename: J B
authors.initials: JB
authors.lastname: Shotwell
authors.forename: R D
authors.initials: RD
authors.lastname: White
authors.forename: I
authors.initials: I
authors.lastname: Drutu
authors.forename: D T
authors.initials: DT
authors.lastname: Petsch
authors.forename: T V
authors.initials: TV
authors.lastname: Nheu
authors.forename: H
authors.initials: H
authors.lastname: He
authors.forename: Y
authors.initials: Y
authors.lastname: Hirokawa
authors.forename: H
authors.initials: H
authors.lastname: Maruta
authors.forename: J L
authors.initials: JL
authors.lastname: Wood
mesh_terms: D000478:Alkylation; D002227:Carbazoles / Q000138:chemical synthesis*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D026121:Indole Alkaloids; D008968:Molecular Conformation; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013237:Stereoisomerism
chemical_list: D002227:Carbazoles; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D026121:Indole Alkaloids; C049985:staurosporine aglycone; D011493:Protein Kinase C