Dynamic Nef and Nef dynamics: how structure could explain the complex activities of this small HIV protein.
The Nef protein of the human immunodeficiency virus is as important for disease progression as it is perplexing in its plethora of target molecules and functions. In this article, it is proposed that the complex biology of Nef is regulated through conformational changes of the protein that are triggered by cellular location and specific interactions as Nef traffics through the infected cell.
Arold
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Centre de Biochimie Structurale, UMR C5048 CNRS, U553 INSERM, Faculté de Pharmacie, Avenue C. Flahault, F-34060 Montpellier, France.
Baur
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D000595:Amino Acid Sequence; D015693:Gene Products, nef / Q000737:chemistry* / Q000378:metabolism*; D015497:HIV-1 / Q000378:metabolism*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D021381:Protein Transport; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship; D054311:nef Gene Products, Human Immunodeficiency Virus
D015693:Gene Products, nef; D054311:nef Gene Products, Human Immunodeficiency Virus