title: Identification of sequence selective receptors for peptides with a carboxylic acid terminus.
abstract: Split-and-mix libraries of resin-bound "tweezer" receptors have been prepared and screened to identify receptors for dye-labelled tripeptides. The receptors incorporate a diamidopyridine unit to serve as a specific recognition site for the CO2H group, leading to strong and selective receptors for peptide guests with a CO2H terminus. The role of the dye-label, attached to the peptide guest to allow visualisation of selective recognition events in the screening experiments, has also been examined and was found to have a significant influence on the binding selectivities.
authors.affiliation: Department of Chemistry, University of Southampton, Highfield, UK.
authors.forename: T
authors.initials: T
authors.lastname: Braxmeier
authors.forename: M
authors.initials: M
authors.lastname: Demarcus
authors.forename: T
authors.initials: T
authors.lastname: Fessmann
authors.forename: S
authors.initials: S
authors.lastname: McAteer
authors.forename: J D
authors.initials: JD
authors.lastname: Kilburn
mesh_terms: D000595:Amino Acid Sequence; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D018716:Molecular Mimicry; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000378:metabolism*; D011485:Protein Binding; D018000:Receptors, Peptide / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity
chemical_list: D019151:Peptide Library; D010455:Peptides; D018000:Receptors, Peptide