In vitro hepatobiotransformation of sulphadimethoxine in laying hens.
The biotransformation of sulphadimethoxine (SDM) was estimated in liver post-mitochondrial supernatants (S-9) from laying hens. The pathway and activity for hen S-9 were compared with those for cow and pig S-9. The formation of the hydroxylation of SDM, 6-hydroxy SDM (6-OH-SDM), was found only with hen S-9. The N4-acetylating activity of SDM in hen S-9 was lower than in cow and pig S-9. All S-9 from the three species de-acetylated N4-acetyl SDM (N4-AcSDM). With respect to the hydroxylation and N4-acetylation rates in hen S-9, the values incubated at 41 degrees C were higher than those at 37 degrees C (P < 0.01).
Furusawa
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Faculty of Human Life Science, Osaka City University, Osaka, Japan.
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D001711:Biotransformation; D002645:Chickens / Q000378:metabolism*; D046508:Culture Techniques / Q000662:veterinary; D005260:Female; D008099:Liver / Q000378:metabolism*; D013412:Sulfadimethoxine / Q000378:metabolism*; D013696:Temperature
D000890:Anti-Infective Agents; D013412:Sulfadimethoxine