title: Activity against plant pathogenic fungi of phomalactone isolated from Nigrospora sphaerica.
abstract: Phomalactone, 5,6-dihydro-5-hydroxy-6-prop-2-enyl-2H-pyran-2-one, produced by the fungus Nigrospora sphaerica, was tested in vitro against nine plant pathogenic fungi, and specifically inhibited the mycelial growth of Phytophthora infestans, with an MIC value of 2.5 mg litre-1. Its inhibitory activities against sporangium and zoospore germination of P infestans were similar to those against Phytophthora capsici. In vivo, at 100 and 500 mg litre-1, it reduced the development of tomato late blight caused by P infestans.
authors.affiliation: Screening Division, Korea Research Institute of Chemical Technology, PO Box 107, Yusong-Gu, Taejon 305-600, Korea. kjinc@krict.re.kr
authors.forename: J C
authors.initials: JC
authors.lastname: Kim
authors.forename: G J
authors.initials: GJ
authors.lastname: Choi
authors.forename: J H
authors.initials: JH
authors.lastname: Park
authors.forename: H T
authors.initials: HT
authors.lastname: Kim
authors.forename: K Y
authors.initials: KY
authors.lastname: Cho
mesh_terms: D001203:Ascomycota / Q000737:chemistry* / Q000302:isolation & purification; D005659:Fungicides, Industrial / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000145:classification / Q000187:drug effects*; D009868:Oomycetes / Q000145:classification / Q000187:drug effects*; D010935:Plant Diseases / Q000382:microbiology*; D011753:Pyrones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet
chemical_list: C442280:5,6-dihydro-5-hydroxy-6-prop-2-enyl-2H-pyran-2-one; D005659:Fungicides, Industrial; D011753:Pyrones