Current efficacy of postexposure prophylaxis against measles with immunoglobulin.
We assessed results after postexposure prophylaxis against measles with immunoglobulin administered intramuscularly. Children were given 0.33 mL/kg of immunoglobulin from commercially available lots containing various titers of measles antibody within 5 days after exposure. In children receiving immunoglobulin with a titer of < or =16 IU/mL, 57% had clinically evident measles. Immunoglobulin preparations with higher measles antibody titers are required.
Endo
A
A
Division of Pediatrics, Itabashi Ward Medical Association Hospital, Takashimadaira 3-12-6, Itabashi-ku, Tokyo 175-0082, Japan.
Izumi
H
H
Miyashita
M
M
Taniguchi
K
K
Okubo
O
O
Harada
K
K
D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage*; D007223:Infant; D008297:Male; D008457:Measles / Q000276:immunology / Q000517:prevention & control*
D007136:Immunoglobulins