[The effect of iron and zinc on lead absorption in the tunica mucosa of various parts of rat small intestine ].
Kuring experiments on turned out sacs models of duodenum, jejunum and ileum of rats the differences in levels of exogenous Pb2+ absorption were revealed. The most values were in tunica mucosa (TM) of duodenum and jejunum. Pb2+ absorption was influenced by previous exposure to trace elements (TE) of Fe2+ (0.79 mmole/100 g) and Zn2+ (0.36 mmole/100 g) having been inducted to stomach. TE due to their physical and chemical properties reduced Pb2+ absorption in different parts of intestine TM on the average by 14-49%. It was determined that TE prevented Pb2+ absorption in TM of intestine more effectively during combined introduction compared to isolated one (accordingly 42% in duodenum, 43% in ileum and 29% in jejunum). Reducing Pb+ absorption is explained by probable substrates competition for active centers of their binding and transfer to TM to intestine.
Luhovs'kyĭ
S P
SP
Ukrainian Scientific Research Institute of Industrial Medicine, Ministry of Public Health, Krivoy Pog.
D000818:Animals; D004386:Duodenum / Q000378:metabolism; D007082:Ileum / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism*; D007501:Iron / Q000378:metabolism / Q000494:pharmacology*; D007583:Jejunum / Q000378:metabolism; D007854:Lead / Q000378:metabolism*; D051381:Rats; D014131:Trace Elements / Q000378:metabolism / Q000494:pharmacology; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology*
D014131:Trace Elements; D007854:Lead; D007501:Iron; D015032:Zinc