Childhood cancer incidence in a cohort of twin babies.
We studied childhood cancer incidence in a population-based twin cohort using record linkage to the National Registry of Childhood Tumours. After correcting for mortality, an incidence deficit was observed (Standardized Incidence Ratio (SIR) 79; 95% Confidence Interval (CI) 39-120). Pooled analysis with data from published cohort studies indicates a similar significant incidence reduction (SIR 81, 95% CI 67-96). Further studies are warranted.
Murphy
M F
MF
Imperial Cancer Research Fund, General Practice Research Group, Institute of Health Sciences, Old Road, Headington, Oxford, OX3 7LF, UK.
Whiteman
D
D
Hey
K
K
Griffith
M
M
Gill
L
L
Goldacre
M J
MJ
Vincent
T J
TJ
Bunch
K
K
D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D015331:Cohort Studies; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009369:Neoplasms / Q000453:epidemiology*; D012042:Registries