title: [Myasthenia gravis and sleep].
abstract: In myasthenia gravis respiratory function is often disturbed in the night, especially during REM sleep, despite of normal daytime respiratory function. Nevertheless, nocturnal respiratory problems are rarely diagnosed. Sleepiness, concentration and memory problems can be symptoms of a sleep related breathing disorder. Reports of reduction of REM sleep, memory dysfunction, and detection of acetylcholine receptor (AchR)-antibodies in the cerebrospinal fluid have lead to the hypothesis of a central nervous system involvement in myasthenia gravis. Possible mechanisms are centrally acting AchR-antibodies, unspecifically acting cytokines and hypoxia, possibly the most important influence upon REM sleep reduction and impaired cognitive function. In a patient presenting possible CNS-involvement (cephalea, fatigue, concentration and memory problems), a polysomnographic investigation should therefore be performed to detect a sleep related breathing disorder.
authors.affiliation: Universitätsklinik für Neurologie, Wien, Osterreich.
authors.forename: R
authors.initials: R
authors.lastname: Stepansky
authors.forename: J
authors.initials: J
authors.lastname: Zeitlhofer
mesh_terms: D001323:Autoantibodies / Q000134:cerebrospinal fluid; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D006801:Humans; D008569:Memory Disorders / Q000209:etiology*; D009157:Myasthenia Gravis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000276:immunology; D012891:Sleep Apnea Syndromes / Q000134:cerebrospinal fluid / Q000209:etiology*; D012895:Sleep, REM
chemical_list: D001323:Autoantibodies; D002800:Cholinesterase Inhibitors; D011950:Receptors, Cholinergic