P-450 Eicosanoids: A Novel Signaling Pathway Regulating Renal Function.
Cytochrome P-450 enzymes primarily metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney. These compounds serve as second messengers that play a central role in the regulation of renal vascular tone and sodium reabsorption in the proximal tubule and thick ascending loop of Henle.
Roman
Richard J.
RJ
Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.
Alonso-Galicia
Magdalena
M