title: [The acute phase reaction in laparoscopic and open surgery of inguinal hernias].
abstract: The acute phase response to tissue injury is art of the wound healing process after surgery. The aim of study was to determine levels of acute phase proteins and levels of thrombocytes in patients with laparoscopic surgery (intraabdominal preperitoneal repair) and in patients with open surgery (tension free repair). Exclusion criteria in both groups of patients: malignity, diabetes mellitus, obesity (BMI > 30), infection, hypoproteinemia, hepatic or renal insufficiency and hypertension. Type of anaesthesia: general. Perioperative preventive antithrombotic medication: LMWH 5 days after surgery. The observed parameters were estimated before, one hour, 2nd and 7th days after surgery. Statistical test: ANOVA, statistical by significant difference p < 0.05. The results of the study demonstrate an increase of acute phase proteins CRP, OROSO and Fb in both groups of patients in comparison to their levels before surgery. In this respect we did not find a difference between the two types of operation. In patients with laparoscopic surgery the observed peak of FBG increase (+69%) was on the 2nd day after surgery followed by a slight drop of values in comparison to the results of open surgery patients with a FBG increase on the 2nd day (+42%) and with continuation on the 7th (%) postoperative day. The peak of CRP values was on the 2nd day in both groups. OROSO values increased even on the 7th day. The same situation occurred with Plt levels (p < 0.05). We suggested, that laparoscopic and open surgery of inguinal hernia repair are both followed by an acute phase response related to the tissue injury and this response perists even 1 week after surgery. But the recovery time of some parameters of the acute phase response (e.g. orosomucoid and fibrinogen levels) to the basical preoperative state is longer in patients with open type of surgery. We do not confirm differences in the degree of risk of postoperative thrombophilia in both types of surgery and suggest, that the prevention of thromboembolic complications is indicated in both types of surgery.
authors.affiliation: I. chirurgická klinika VFN a UK Praha.
authors.forename: Z
authors.initials: Z
authors.lastname: Krska
authors.forename: J
authors.initials: J
authors.lastname: Kvasnicka
authors.forename: M
authors.initials: M
authors.lastname: Pesková
authors.forename: D
authors.initials: D
authors.lastname: Melechovský
authors.forename: R
authors.initials: R
authors.lastname: Demes
authors.forename: J
authors.initials: J
authors.lastname: Polívková
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000210:Acute-Phase Reaction / Q000097:blood* / Q000209:etiology; D000328:Adult; D002097:C-Reactive Protein / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006552:Hernia, Inguinal / Q000601:surgery*; D006801:Humans; D010535:Laparoscopy; D008875:Middle Aged; D009961:Orosomucoid / Q000032:analysis; D011184:Postoperative Period
chemical_list: D000209:Acute-Phase Proteins; D009961:Orosomucoid; D005340:Fibrinogen; D002097:C-Reactive Protein