Effect of Laticauda semifasciata (sea snake) venom on chloride transport across the frog skin.
Addition of Laticauda semifasciata venom to the outside bathing solution of isolated frog skin elicited sustained increases in transepithelial potential difference, short-circuit current and transepithelial electrical resistance. The Laticauda semifasciata venom-induced short-circuit is carried by a net active Na+ transfer from the outside to the inside bathing solution while the increase in transepithelial resistance is accounted for by a decrease in the outside to inside Cl- flux.
Gerencser
G A
GA
Department of Physiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA. gag@phys.med.ufl.edu
Cornette
K M
KM
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism*; D004546:Elapid Venoms / Q000494:pharmacology*; D066298:In Vitro Techniques; D011868:Radioisotopes; D011892:Rana catesbeiana; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D002712:Chlorides; D004546:Elapid Venoms; D011868:Radioisotopes; D012964:Sodium