Hypnotic and cardiovascular effects of proprietary and generic propofol formulations do not differ.
OBJECTIVE
The aim of the study was to compare the potency of two different propofol formulations: proprietary and generic propofol using the bispectral index (BIS) monitoring.


METHODS
Forty female patients undergoing breast surgery received propofol 3 mg x kg(-1) followed by propofol infusion adjusted to maintain a 40% BIS value, supplemented by 50% nitrous oxide. Proprietary or generic propofol was administered in a randomized double-blind manner.


RESULTS
The propofol mg/BIS% ratio obtained after the bolus dose, the cumulative infused propofol mg/BIS% ratio at the end of each five-minute interval and the total dose of propofol administered as bolus + infusion were similar between the two groups. The two groups did not differ with regard to systolic and diastolic blood pressure, heart rate, end-tidal carbon dioxide and arterial oxygen saturation.


CONCLUSIONS
The two propofol formulations are equipotent when hypnotic effect is assessed by BIS monitoring.
Fassoulaki
A
A
Department of Anesthesia, St Savas Hospital, Athens, Greece. afassoul@otenet.gr
Paraskeva
A
A
Papilas
K
K
Patris
K
K
D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000601:surgery; D004569:Electroencephalography / Q000187:drug effects; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage* / Q000494:pharmacology*; D015742:Propofol / Q000008:administration & dosage* / Q000494:pharmacology*; D013810:Therapeutic Equivalency
D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D015742:Propofol