Effects of xerostomia on perception and performance of swallow function.
BACKGROUND
Head and neck cancer treatment with high-dose chemoradiation may cause xerostomia and affect the patient's perception of swallowing ability.


METHODS
Whole saliva production was measured in 36 patients with advanced-stage cancer of the oropharynx before treatment and 3 months after treatment by weighing a 4 x 4 inch gauze before and after a 2-minute chewing period. Presence of multiple eating difficulties was measured by patient interview. Swallowing was examined videofluorographically (VFG).


RESULTS
Saliva weight decreased from a mean (SEM) of 5.1 (0.5) g pretreatment to 1.4 (0.5) g after treatment (p<.0001). At 3 months, significantly more patients perceived difficulty swallowing, dry mouth, needing water while eating, food stuck in the mouth or throat, and change in taste. Saliva weight was not correlated with VFG measures of bolus transit or observations of residue.


CONCLUSIONS
Chemoradiation treatment results in xerostomia and a significant increase in patient perception of swallowing difficulties. Saliva weight in patients who perceive swallowing problems was lower. Xerostomia did not affect the physiologic aspects of bolus transport. Xerostomia affected the sensory process and comfort of eating more than bolus transport.
Logemann
J A
JA
Department of Communication Sciences and Disorders, Northwestern University, 2299 North Campus Drive, Evanston, Illinois 60208, USA.
Smith
C H
CH
Pauloski
B R
BR
Rademaker
A W
AW
Lazarus
C L
CL
Colangelo
L A
LA
Mittal
B
B
MacCracken
E
E
Gaziano
J
J
Stachowiak
L
L
Newman
L A
LA
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D003679:Deglutition / Q000502:physiology*; D003680:Deglutition Disorders / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009959:Oropharyngeal Neoplasms / Q000628:therapy*; D010465:Perception; D011878:Radiotherapy / Q000009:adverse effects; D014987:Xerostomia / Q000150:complications / Q000209:etiology* / Q000503:physiopathology*
D000970:Antineoplastic Agents