[Drugs affect and are affected by body temperature].
There are several connections between drugs and cold. Drugs can lower body temperature; ambient temperature together with the adaptive capacity of the organism can influence various physiological and also pharmacological processes; furthermore, hypothermia can have an effect on drug pharmacokinetics and pharmacodynamics which is of considerable clinical importance, since the application of hypothermia as a therapeutic adjuvant is on the rise. The present paper discusses different aspects of these problems, concluding with a proposal that it may now be time to ask for the results of a "cold effect test" before a new drug is accepted for common use, especially in hypothermic patients.
Johansson
B W
BW
Hjärt-lungkliniken, sektionen för kardiologi, Universitetssjukhuset MAS, Malmö.
D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D007035:Hypothermia / Q000139:chemically induced / Q000378:metabolism*; D007036:Hypothermia, Induced; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010599:Pharmacokinetics; D010601:Pharmacology, Clinical
D004364:Pharmaceutical Preparations