title: Water-accelerated tandem Claisen rearrangement-catalytic asymmetric carboalumination.
abstract: [reaction: see text] The addition of stoichiometric quantities of water accelerates both the trimethylaluminum-mediated aromatic Claisen reaction and the chiral zirconocene-catalyzed asymmetric carboalumination of terminal alkenes. The two reactions occur in a tandem sequence resulting in the selective formation of two new C-C and one C-O bond after oxidative quench of the intermediate trialkylalane.
authors.affiliation: Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
authors.forename: P
authors.initials: P
authors.lastname: Wipf
authors.forename: S
authors.initials: S
authors.lastname: Ribe