[Homonymous lateral hemianopsia revealing cerebral thrombophlebitis. Role of a deficiency of protein S induced by l-asparaginase].
BACKGROUND
Cerebral thrombosis associated with protein S deficiency is very rare and is mainly related to hereditary form of protein S deficiency.


METHODS
A 19-year-old girl with acute lymphoblastic leukemia presented hemianopsy within a few days after the first administration of L-asparaginase. Magnetic resonance of the brain showed a cortical infarct. A marked decrease of the level of protein S was documented. Few days later, the patient was free of symptoms and protein S level was restored to the normal suggesting that the cerebral thrombosis was caused by transient protein S deficiency induced by L-asparaginase administration.


CONCLUSIONS
Patients with neurological complication caused by L-asparaginase should be tested for protein S and other anticoagulant deficiencies.
Millot
F
F
Service d'Oncologie hématologique et de Thérapie cellulaire, CHU de Poitiers, 350, avenue Jacques Coeur, BP 577, F 86021 Poitiers.
Traore
P
P
Boinot
C
C
Vandermarcq
P
P
Sadoun
A
A
Brizard
A
A
Guilhot
F
F
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D001780:Blood Coagulation Tests; D002540:Cerebral Cortex / Q000473:pathology; D002544:Cerebral Infarction / Q000139:chemically induced / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006423:Hemianopsia / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D020766:Intracranial Embolism / Q000139:chemically induced* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D018455:Protein S Deficiency / Q000139:chemically induced* / Q000175:diagnosis; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000175:diagnosis
D001215:Asparaginase