Atrial Natriuretic Peptide: Regulator of Chronic Arterial Blood Pressure.
Recent findings in atrial natriuretic peptide (ANP) transgenic and gene knockout mouse models uncovered a tonic vasodilatory effect of this hormone that contributes to chronic blood pressure homeostasis. With elevated salt intake, ANP-mediated antagonism of the renin-angiotensin system is essential for blood pressure constancy, suggesting that a deficiency in ANP activity may underlie the etiology of sodium-retaining disorders.
Melo
Luis Gabriel
LG
Department of Physiology of the University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
Pang
Stephen C.
SC
Ackermann
Uwe
U