title: Functional Modulation of Cardiac ATP-Sensitive K(+) Channels.
abstract: ATP-sensitive K(+) (K(ATP)) channels are inhibited by intracellular ATP, but MgATP is necessary to maintain the channel activity. Numerous cofactors modulate channel function. K(+) channel openers activate and sulfonylureas inhibit K(ATP) channels. The structure of cardiac K(ATP) channel is a complex of mainly K(IR)6.2 and SUR2a. Activation of cardiac K(ATP) channels contributes to action potential shortening during ischemia and plays a role in cardioprotection.
authors.affiliation: Dept. of Cardiovascular Diseases, Medical Research Institute, Tokyo Medical and Dental University, 1-5-45, Yushima, Bunkyo-ku, Tokyo 113 Japan.
authors.forename: Masayasu
authors.initials: M
authors.lastname: Hiraoka
authors.forename: Tetsushi
authors.initials: T
authors.lastname: Furukawa