Artificial ribozymes and deoxyribozymes.
RNA and DNA molecules with catalytic properties have been isolated by in vitro selection from combinatorial nucleic acid libraries. A broad range of chemical reactions is catalyzed and nucleic acids can accelerate bond formation between small organic substrates. The catalytic performance of nucleic acids can be enhanced by the incorporation of additional functional groups.
Jäschke
A
A
Freie Universität Berlin, Department of Biology, Chemistry and Pharmacy, Institute of Chemistry, Thielallee 63, D-14195, Berlin, Germany. jaschke@chemie.fu-berlin.de
D019143:Evolution, Molecular; D009696:Nucleic Acids / Q000737:chemistry / Q000378:metabolism; D016337:RNA, Catalytic / Q000737:chemistry* / Q000378:metabolism*
D009696:Nucleic Acids; D016337:RNA, Catalytic