Intracellular Ca(2+) pools in neuronal signalling.
Different intracellular pools participate in generating Ca(2+) signals in neuronal cells and in shaping their spatio-temporal patterns. They include the endoplasmic reticulum (endowed with different classes of Ca(2+) channels, with distinct functional properties and highly defined expression patterns in the brain), the Golgi apparatus, and the mitochondria. The release of Ca(2+) from intracellular pools plays an important role in controlling processes such as neurite outgrowth, synaptic plasticity, secretion and neurodegeneration.
Rizzuto
R
R
Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari 46, 44100, Ferrara, Italy. r.rizzuto@unife.it
D000818:Animals; D002118:Calcium / Q000502:physiology; D015220:Calcium Channels / Q000502:physiology; D020013:Calcium Signaling; D002352:Carrier Proteins / Q000502:physiology; D002451:Cell Compartmentation / Q000502:physiology*; D003712:Dendrites / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000378:metabolism; D000072233:Homer Scaffolding Proteins; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007424:Intracellular Fluid / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D017136:Ion Transport; D008928:Mitochondria / Q000502:physiology; D008959:Models, Neurological; D009024:Morphogenesis; D009410:Nerve Degeneration; D009419:Nerve Tissue Proteins / Q000502:physiology; D016501:Neurites / Q000378:metabolism / Q000648:ultrastructure; D019636:Neurodegenerative Diseases / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D009479:Neuropeptides / Q000502:physiology; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
D015220:Calcium Channels; D002352:Carrier Proteins; D000072233:Homer Scaffolding Proteins; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D018160:Receptors, Cytoplasmic and Nuclear; D016194:Receptors, N-Methyl-D-Aspartate; D002118:Calcium