Effects of carp and tuna oils on 5-fluorouracil-induced antitumor activity and side effects in sarcoma 180-bearing mice.
In this study, we examined the effects of fish oils on 5-fluorouracil (5-FU)-induced antitumor activity in mice. First, we examined the antitumor activity of the oral administration of two fish oils (carp oil and tuna oil) in sarcoma 180-bearing mice. Carp oil (0.2 and 0.4 mL/mouse) and tuna oil (0.2 and 0.4 mL/mouse) had no effects on tumor growth. Next, we examined the combined effects of 5-FU plus two fish oils (carp oil and tuna oil) on the antitumor activity and side effects compared to the effects of 5-FU alone (12.5 mg/kg/d). We found that carp oil (0.4 mL/mouse) or tuna oil (0.2 or 0.4 mL/mouse) enhanced the ability of 5-FU (12.5 mg/kg/d) to prevent tumor growth, without increasing side effects such as myelotoxicity and immunocompetent organ toxicity. Tuna oil (0.2 mL/mouse) slightly reduced body weight as compared to the effects of 5-FU alone and water alone (control). The area under the curve (AUC) (0-120 min) of blood 5-FU levels was reduced by the oral co-administration of 5-FU with carp oil or tuna oil. Apparent Tmax was shortened by the oral co-administration of 5-FU with carp oil or tuna oil. On the other hand, AUC (0-4 h) of 5-FU incorporation into tumor RNA fraction was not affected by the oral co-administration of 5-FU with carp oil or tuna oil.
Kimura
Y
Y
Second Department of Medical Biochemistry, School of Medicine, Ehime University, Japan. yokim@m.ehime-u.ac.jp
Takaku
T
T
Nakajima
S
S
Okuda
H
H
D000818:Animals; D002347:Carps; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004347:Drug Interactions; D005395:Fish Oils / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005472:Fluorouracil / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012334:RNA, Neoplasm / Q000378:metabolism; D012510:Sarcoma 180 / Q000188:drug therapy* / Q000473:pathology; D014413:Tuna
D004042:Dietary Fats, Unsaturated; D005395:Fish Oils; D012334:RNA, Neoplasm; D005472:Fluorouracil