Antituberculous activity of norfloxacin mannich bases with isatin derivatives.
Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The compounds were evaluated in vitro against Mycobacterium tuberculosis H37R(v) at 12.5 microg/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower than 6.25 microg/ml.
Pandeya
S N
SN
Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India. snpande@banaras.ernet.in
Sriram
D
D
Yogeeswari
P
P
Ananthan
S
S
D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007510:Isatin / Q000138:chemical synthesis / Q000494:pharmacology*; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009643:Norfloxacin / Q000138:chemical synthesis / Q000494:pharmacology*
D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D008352:Mannich Bases; D007510:Isatin; D009643:Norfloxacin