Post-genomic nematode parasitology.
The future direction of post-genomic nematode parasitology should focus on the function of the genes that are defined by large-scale expressed sequence tag sequencing and on broader questions about the genetic basis of parasitism. Functional characterisation will require the application of high throughput technologies that have been developed in other fields, including genome mapping strategies and DNA microarray analysis. These will be greatly aided by the development and application of appropriate model organisms. It is crucial that the field make the transition from a narrow focus on one or a few genes at a time to a focus on whole genomes in order to fully realise the potential of the expressed sequence tag and other genomic projects currently under way.
Grant
W N
WN
School of Biological Sciences, Flinders University of South Australia, Adelaide, South Australia, Australia. warwick.grant@agresearch.co.nz
Viney
M E
ME
D000818:Animals; D002874:Chromosome Mapping; D019295:Computational Biology; D020224:Expressed Sequence Tags; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology; D018503:Genome, Protozoan; D009348:Nematoda / Q000235:genetics* / Q000502:physiology; D020411:Oligonucleotide Array Sequence Analysis