title: Recent research on alcohol tolerance and dependence.
abstract: This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Hiroshi Suwaki and Harold Kalant. The presentations were (1) Influence of ADH genotypes on acute alcohol withdrawal syndrome in Japanese, by Susumu Higuchi; (2) Use of genetic analyses to refine phenotypes related to alcohol tolerance and dependence, by John C. Crabbe; (3) Neurochemical basis for alcohol dependence, by Seitaro Ohkuma and Masashi Katsura; (4) Adenylyl cyclase and development of tolerance to addictive drugs, by Masami Yoshimura; (5) Tolerance in rat lines selectively bred for alcohol preference, by Robert C. Stewart and Ting-Kai Li; and (6) Ethanol reinforcement, dependence, and vulnerability to relapse: Interactions between neuroadaptive and conditioning factors, by Friedbert Weiss.
authors.affiliation: Department of Neuropsychiatry (HS), Kagawa Medical University, Kagawa, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Suwaki
authors.forename: H
authors.initials: H
authors.lastname: Kalant
authors.forename: S
authors.initials: S
authors.lastname: Higuchi
authors.forename: J C
authors.initials: JC
authors.lastname: Crabbe
authors.forename: S
authors.initials: S
authors.lastname: Ohkuma
authors.forename: M
authors.initials: M
authors.lastname: Katsura
authors.forename: M
authors.initials: M
authors.lastname: Yoshimura
authors.forename: R C
authors.initials: RC
authors.lastname: Stewart
authors.forename: T K
authors.initials: TK
authors.lastname: Li
authors.forename: F
authors.initials: F
authors.lastname: Weiss
mesh_terms: D000426:Alcohol Dehydrogenase / Q000235:genetics; D000437:Alcoholism / Q000235:genetics*; D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D000071396:Aldehyde Dehydrogenase, Mitochondrial; D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology; D004361:Drug Tolerance / Q000235:genetics*; D005838:Genotype; D006801:Humans; D051379:Mice; D010641:Phenotype; D012054:Reinforcement, Psychology; D012106:Research; D012307:Risk Factors; D055502:Secondary Prevention; D013375:Substance Withdrawal Syndrome / Q000235:genetics*
chemical_list: D000426:Alcohol Dehydrogenase; C096127:ALDH2 protein, human; D000444:Aldehyde Dehydrogenase; D000071396:Aldehyde Dehydrogenase, Mitochondrial