A study of prolidase in mothers, their newborn babies and in non-pregnant controls.
The prolidase activity in serum and in erythrocytes was measured in 28 healthy mothers and in the cord blood of their newborn babies in using a modified Chinard method. 45 healthy non-pregnant women aged between 15-36 years formed a control group. Biochemical parameters (CK, BUN, C-peptid, AFP, Uric acid) were also measured. The serum and erythrocyte prolidase activities in maternal blood were 45.8+/-13.4 U/L and 37.8+/-2.7 U/g Hb respectively. There was no significant difference in the enzyme activities between pregnant women and the control group (p>0.05). However serum and erythrocyte prolidase activity in cord blood (20.3+/-8.2 U/L and 31.6+/-7.3 U/g Hb) was significantly different when compared with control group (53.4+/-14.7 U/L in serum and 42.3+/-10.3 U/g Hb in erythrocyte, p<0.001). There was a significant correlation between maternal and cord blood serum enzyme activity (r: 0.76 p<0.01). This correlation was also shown in erythrocyte prolidase activities of both groups (r: 0.49, p<0.05). Cord blood prolidase activity was positively correlated with birth weight (r: 0.89, p<0.01). Prolidase activity in cord blood was low even though collagen turnover is increased in fetal growth.
Namiduru
E S
ES
Department of Biochemistry and Clinical Biochemistry, University of Gaziantep, Faculty of Medicine, Sehitkamil, Gaziantep, Turkey. enamiduru@hotmail.com
Ozdemir
Y
Y
Kutlar
I
I
Ersoy
U
U
D000293:Adolescent; D000328:Adult; D001806:Blood Urea Nitrogen; D002096:C-Peptide / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D004150:Dipeptidases / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D000509:alpha-Fetoproteins / Q000032:analysis
D002096:C-Peptide; D006454:Hemoglobins; D000509:alpha-Fetoproteins; D003402:Creatine Kinase; D004150:Dipeptidases; C022449:proline dipeptidase