title: Diagnostic value of pituitary MRI in differentiation of children with normal growth hormone secretion, isolated growth hormone deficiency and multiple pituitary hormone deficiency.
abstract: Pituitary height, volume and morphology were investigated by MRI in patients aged 3.5-24.9 years with growth hormone deficiency (GHD) in relation to birth history and hormonal findings. Three groups with comparable age, sex and pubertal stage were studied: group I (n=42)--patients with isolated growth hormone deficiency (IGHD); group II (n=22)-- patients with multiple pituitary hormone deficiency (MPHD); and group III (n=30)--healthy controls. Pituitary height and volume differed significantly between the three groups, with the smallest in group II and largest in group III (p <0.001 for both). Both variables correlated significantly with peak GH value in the patient groups (p <0.001). The specificity of pituitary dysmorphology in the determination of GHD was 100% and its sensitivity in differentiation of IGHD and MPHD was 95%. Ectopic neurohypophysis was present in 75% of breech births and 27% of head-presenting patients (p <0.01). This study emphasizes the differential diagnostic value of pituitary MRI and its contribution to the understanding of the pathogenesis and prognosis in GHD.
authors.affiliation: Division of Endocrinology, Göztepe Educational Hospital of SSK, Istanbul, Turkey. karslanoglu@yahoo.com
authors.forename: I
authors.initials: I
authors.lastname: Arslanoğlu
authors.forename: H
authors.initials: H
authors.lastname: Kutlu
authors.forename: P
authors.initials: P
authors.lastname: Işgüven
authors.forename: F
authors.initials: F
authors.lastname: Tokuş
authors.forename: K
authors.initials: K
authors.lastname: Işik
mesh_terms: D000293:Adolescent; D001946:Breech Presentation; D002648:Child; D002828:Choristoma / Q000150:complications / Q000453:epidemiology; D003937:Diagnosis, Differential; D005260:Female; D019382:Human Growth Hormone / Q000097:blood / Q000172:deficiency* / Q000378:metabolism*; D006801:Humans; D007746:Labor Presentation; D008279:Magnetic Resonance Imaging; D008297:Male; D009929:Organ Size; D010902:Pituitary Gland / Q000473:pathology*; D010904:Pituitary Gland, Posterior; D010907:Pituitary Hormones / Q000172:deficiency*; D011247:Pregnancy; D012016:Reference Values; D012680:Sensitivity and Specificity
chemical_list: D010907:Pituitary Hormones; D019382:Human Growth Hormone