UTP as an extracellular signaling molecule.
In addition to their central role in many biochemical processes, uridine nucleotides are important extracellular signaling molecules that regulate a broad spectrum of cell functions via activation of P2Y2, P2Y4, and P2Y6 receptors. Cellular release of UTP provides a mechanism for autocrine control of calcium- or protein kinase C-dependent processes.
Lazarowski
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ER
School of Medicine, Department of Medicine, The Cystic Fibrosis Treatment and Research Center, University of North Carolina, Chapel Hill, NC 27599-7248, USA.
Boucher
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RC
D000818:Animals; D005110:Extracellular Space / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D014544:Uridine Triphosphate / Q000502:physiology*
D014544:Uridine Triphosphate