title: Two cases of long lasting bacteremia due to Mycobacterium avium complex despite new macrolides-containing regimens in patients with acquired immunodeficiency syndrome.
abstract: The prognosis of Mycobacterium avium complex (MAC) infection has been improved by new macrolides-containing regimens and the use of highly active antiretroviral therapy (HAART) in the treatment of acquired immunodeficiency syndrome (AIDS). We report on two AIDS cases with long lasting bacteremia due to MAC under this regimen. Both patients experienced problems due to side effects from the anti-MAC regimen and from an immune-reconstitution syndrome related to HAART. MAC infection persisted despite treatment, however, no anti-MAC drug-resistant isolates emerged throughout the clinical course in either case. These cases demonstrate that therapy for disseminated MAC infection is sometimes difficult even with HAART and macrolides-containing regimens.
authors.affiliation: AIDS Clinical Center, International Medical Center of Japan, Tokyo.
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: A
authors.initials: A
authors.lastname: Yasuoka
authors.forename: N
authors.initials: N
authors.lastname: Tachikawa
authors.forename: K
authors.initials: K
authors.lastname: Teruya
authors.forename: I
authors.initials: I
authors.lastname: Genka
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: C
authors.initials: C
authors.lastname: Yasuoka
authors.forename: Y
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: A
authors.initials: A
authors.lastname: Yoneyama
authors.forename: S
authors.initials: S
authors.lastname: Oka
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000328:Adult; D000900:Anti-Bacterial Agents / Q000009:adverse effects* / Q000627:therapeutic use; D023241:Antiretroviral Therapy, Highly Active / Q000009:adverse effects; D016470:Bacteremia / Q000150:complications* / Q000382:microbiology*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007107:Immune System / Q000187:drug effects; D018942:Macrolides; D008297:Male; D009162:Mycobacterium avium / Q000502:physiology; D014376:Tuberculosis / Q000150:complications* / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides