Cardiovascular drug-drug interactions.
The drug-drug interactions discussed in this article have either documented or suspected clinical relevance for patients with cardiovascular disease and the clinician involved in the care of these patients. Oftentimes, drug-drug interactions are difficult, if not impossible, to predict because of the high degree of interpatient variability in drug disposition. Certain drug-drug interactions, however, may be avoided through knowledge and sound clinical judgment. Every clinician should maintain a working knowledge of reported drug-drug interactions and an understanding of basic pharmacokinetic and pharmacodynamic principles to help predict and minimize the incidence and severity of drug-drug interactions.
Anderson
J R
JR
University of New Mexico, College of Pharmacy, Albuquerque, New Mexico, USA.
Nawarskas
J J
JJ
D000042:Absorption / Q000187:drug effects; D000319:Adrenergic beta-Antagonists / Q000009:adverse effects / Q000493:pharmacokinetics; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects / Q000493:pharmacokinetics; D001682:Biological Availability; D002121:Calcium Channel Blockers / Q000009:adverse effects / Q000493:pharmacokinetics; D002317:Cardiovascular Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D003000:Clonidine / Q000009:adverse effects; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism; D004077:Digoxin / Q000009:adverse effects / Q000493:pharmacokinetics; D004232:Diuretics / Q000009:adverse effects; D004347:Drug Interactions; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects / Q000493:pharmacokinetics; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008657:Metabolic Clearance Rate / Q000187:drug effects; D008660:Metabolism / Q000187:drug effects; D009566:Nitrates / Q000009:adverse effects; D011485:Protein Binding / Q000187:drug effects; D013988:Ticlopidine / Q000009:adverse effects; D014018:Tissue Distribution / Q000187:drug effects
D000319:Adrenergic beta-Antagonists; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D002317:Cardiovascular Agents; D004232:Diuretics; D000960:Hypolipidemic Agents; D009566:Nitrates; D004077:Digoxin; D003577:Cytochrome P-450 Enzyme System; D003000:Clonidine; D013988:Ticlopidine