title: Comparative in vitro activity of ABT-773, a novel antibacterial ketolide.
abstract: The in vitro activities of ABT-773, erythromycin, clarithromycin, and azithromycin were compared. ABT-773 was the most active compound against macrolide-susceptible Streptococcus pneumoniae, Streptococcus pyogenes, Staphylococcus aureus, Staphylococcus epidermidis, Listeria monocytogenes, and Enterococcus spp. and multidrug-resistant Streptococcus pneumoniae. It also had good activity against gram-negative and atypical respiratory tract pathogens and Helicobacter pylori.
authors.affiliation: Infectious Diseases Research, Abbott Laboratories, Abbott Park, Illinois 60064-3537, USA. angela.nilius@abbott.com
authors.forename: A M
authors.initials: AM
authors.lastname: Nilius
authors.forename: M H
authors.initials: MH
authors.lastname: Bui
authors.forename: L
authors.initials: L
authors.lastname: Almer
authors.forename: D
authors.initials: D
authors.lastname: Hensey-Rudloff
authors.forename: J
authors.initials: J
authors.lastname: Beyer
authors.forename: Z
authors.initials: Z
authors.lastname: Ma
authors.forename: Y S
authors.initials: YS
authors.lastname: Or
authors.forename: R K
authors.initials: RK
authors.lastname: Flamm
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D016983:Enterococcus / Q000187:drug effects; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D016480:Helicobacter pylori / Q000187:drug effects; D006801:Humans; D048628:Ketolides; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D013997:Time Factors
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D004917:Erythromycin; D017963:Azithromycin; D017291:Clarithromycin; C405499:cethromycin