Protein modules that manipulate histone tails for chromatin regulation.
Histones are the predominant protein components of chromatin and are subject to specific post-translational modifications that are correlated with transcriptional competence. Among these histone modifications are acetylation, phosphorylation and methylation, and recent studies reveal that conserved protein modules mediate the attachment, removal or recognition of these modifications. It is becoming clear that appropriate coordination of histone modifications and their manipulations by conserved protein modules are integral to gene-specific transcriptional regulation within chromatin.
Marmorstein
R
R
The Wistar Institute and the Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA. marmor@wistar.upenn.edu
D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D006657:Histones / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D009687:Nuclear Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D014158:Transcription, Genetic; D015533:Transcriptional Activation
D002843:Chromatin; D006657:Histones; D009687:Nuclear Proteins