Unnatural natural products from the transannular cyclization of lathyrane diterpenes.
The potential of macrocyclic diterpenoids to afford natural product-like polycyclic compounds was demonstrated by the conversion of two lathyrane Euphorbia factors into a series of densely functionalized diterpenoids of unnatural skeletal type. Apparently, Nature is far from having fully exploited the built-in reactivity of these compounds to generate chemical diversity.
Appendino
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Università del Piemonte Orientale, DiSCAFF, Viale Ferrucci 33, 28100 Novara, Italy. appendin@pharm.unito.it
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Jarevång
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D003500:Cyclization; D004224:Diterpenes / Q000737:chemistry*; D019665:Euphorbiaceae / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry
D004224:Diterpenes; D011083:Polycyclic Compounds