Catalytic Asymmetric Vinylogous Mukaiyama-aldol (CAVM) reactions: the enolate activation.
The Catalytic Asymmetric Vinylogous Mukaiyama (CAVM) reactions of various aldehydes with dienolate 1 using different enolate activations (CuF*(S)-TolBinap, t-BuOCu*(S)-Tol-Binap, and various chiral nonracemic ammonium fluorides derived from cinchona alkaloids) are described. These reactions proved to be highly regioselective leading exclusively to the alpha-aldol products in good yields and poor to good enantioselectivities.
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Institut de Chimie des Substances Naturelles, CNRS, F-91198 Gif-sur-Yvette, France.
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