title: [Structure and function of high molecular weight proteinases in human and animal cells].
abstract: The new data that concern structure and functions of high-molecular-mass proteases in animal and human cells are presented in the review. The participation of ATP in mechanisms of proteolysis is considered. Considerable attention is paid to the role of high-molecular-mass multicatalytic proteinase in the regulation of intracellular metabolic processes, cell proliferation, transformation and apoptosis, its involvement in haemopoiesis and immune responses.
authors.affiliation: Department of Animal Physiology and Biochemistry, Institute of Agriculture and Animal Biology, Lviv, Ukraine.
authors.forename: H L
authors.initials: HL
authors.lastname: Antoniak
authors.forename: N O
authors.initials: NO
authors.lastname: Babych
authors.forename: L I
authors.initials: LI
authors.lastname: Solohub
authors.lastname: Snityns'kyĭ
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D002471:Cell Transformation, Neoplastic; D003546:Cysteine Endopeptidases / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D006410:Hematopoiesis / Q000502:physiology; D006801:Humans; D006868:Hydrolysis; D008970:Molecular Weight; D009097:Multienzyme Complexes / Q000737:chemistry* / Q000378:metabolism* / Q000502:physiology; D046988:Proteasome Endopeptidase Complex; D013329:Structure-Activity Relationship
chemical_list: D009097:Multienzyme Complexes; D000255:Adenosine Triphosphate; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex