title: Induction of oxidative stress in antitubercular drug-induced hepatotoxicity.
abstract: OBJECTIVE
  Oxidative stress could play a role in the pathogenesis of antitubercular drug (ATD)-induced hepatotoxicity. We therefore studied the plasma level of reduced glutathione (GSH) and malondialdehyde (MDA) in patients with ATD-induced hepatotoxicity (cases), ATD-treated controls (disease controls) and in healthy volunteers.
  
  
  METHODS
  This study was carried out in a case-control design. Twenty-one cases, 21 age- and sex-matched disease controls, and 10 healthy volunteers were enrolled. Plasma levels of GSH and MDA were measured.
  
  
  RESULTS
  Plasma levels of GSH (median [range] 11.5 [6.2-21.2] mmol/dL) and MDA (1390 [560-2310] nmol/dL) of cases were significantly different (p<0.01) from GSH (18.4 [10.5-24.4]) and MDA (290 [240-550]) of disease controls. Further, plasma GSH and MDA levels of both the ATD-treated groups were different from those in healthy controls.
  
  
  CONCLUSIONS
  Lower levels of plasma GSH and higher levels of MDA may be due to oxidative stress resulting from ATD therapy.
authors.affiliation: Department of Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata. achowdhury@apexmail.com
authors.forename: A
authors.initials: A
authors.lastname: Chowdhury
authors.forename: A
authors.initials: A
authors.lastname: Santra
authors.forename: S
authors.initials: S
authors.lastname: Kundu
authors.forename: A
authors.initials: A
authors.lastname: Mukherjee
authors.forename: A
authors.initials: A
authors.lastname: Pandit
authors.forename: S
authors.initials: S
authors.lastname: Chaudhuri
authors.forename: G K
authors.initials: GK
authors.lastname: Dhali
mesh_terms: D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology*; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D016014:Linear Models; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D014376:Tuberculosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents; D008315:Malondialdehyde; D005978:Glutathione