title: Multiprotein complex signaling and the plasticity problem.
abstract: Synaptic transmission of distinct patterns of spikes, or 'neural code', leads to plastic changes in synapses and other parts of the neuron, as well as learning in animals. Recent findings indicate that specialized multiprotein structures associated with neurotransmitter receptors and cell-adhesion proteins function as molecular devices that both read the neural code and initiate long-term changes in synaptic structure and function.
authors.affiliation: Department of Neuroscience, University of Edinburgh, EH8 9JZ, Edinburgh, UK. seth.grant@ed.ac.uk
authors.forename: S G
authors.initials: SG
authors.lastname: Grant
authors.forename: T J
authors.initials: TJ
authors.lastname: O'Dell
mesh_terms: D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D003598:Cytoskeletal Proteins / Q000502:physiology; D054637:Dual-Specificity Phosphatases; D020690:GTPase-Activating Proteins / Q000502:physiology; D000072233:Homer Scaffolding Proteins; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007473:Ion Channels / Q000502:physiology; D017774:Long-Term Potentiation / Q000502:physiology; D020935:MAP Kinase Signaling System / Q000502:physiology; D046911:Macromolecular Substances; D008322:Mammals; D008959:Models, Neurological; D046912:Multiprotein Complexes; D009419:Nerve Tissue Proteins / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D009479:Neuropeptides / Q000502:physiology; D010749:Phosphoprotein Phosphatases / Q000502:physiology; D021381:Protein Transport; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D020798:Two-Hybrid System Techniques; D020703:ras GTPase-Activating Proteins
chemical_list: D048868:Adaptor Proteins, Signal Transducing; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D003598:Cytoskeletal Proteins; D020690:GTPase-Activating Proteins; D000072233:Homer Scaffolding Proteins; D007473:Ion Channels; D046911:Macromolecular Substances; D046912:Multiprotein Complexes; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D018094:Receptors, Metabotropic Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D017981:Receptors, Neurotransmitter; C484739:SYNGAP1 protein, human; C120531:Shank1 protein, rat; C033652:postsynaptic density proteins; D020703:ras GTPase-Activating Proteins; D011505:Protein-Tyrosine Kinases; D010749:Phosphoprotein Phosphatases; C489855:dual specificity phosphatase 12; D054637:Dual-Specificity Phosphatases