title: Neonates with congenital heart disease.
abstract: Early reparative surgery in neonates and infants with congenital heart disease, as opposed to initial palliation and later repair, is now commonplace. Changes to the conduct of cardiopulmonary bypass, timing of surgery and surgical techniques, and perioperative management substantially have reduced the postoperative mortality and morbidity for these patients. The success of this strategy of early reparative surgery now has been extended to the premature and low-birth-weight newborn, and, along with this, new challenges to postoperative care in the intensive care unit. However, the low mortality associated with two-ventricle repairs has not been the experience in newborns undergoing palliation for single-ventricle defects, in particular, hypoplastic left heart syndrome. A number of articles regarding management of newborns with single-ventricle defects have been published during the past 12 months, ranging from classification, prenatal diagnosis, treatment options, and predictors of both early and late outcome, which may provide a guide for patient management. As mortality has declined, there has been an increased emphasis on identifying indices that may predict outcome or morbidity both before and after surgery, along with possible strategies to attenuate adverse clinical responses. The inflammatory response to bypass is heightened in neonates and infants, and several reports have addressed possible techniques for attenuating the response. In addition, reports regarding the risk for necrotizing enterocolitis, the utility of lactate as an index of systemic perfusion, potential markers of myocardial and neurologic injury, and the use of mechanical support of the circulation in newborns with congenital heart disease are summarized.
authors.affiliation: Harvard Medical School and Cardiac Intensive Care Unit, Children's Hospital, Boston, Massachusetts 02115, USA. peter.laussen@tch.harvard.edu
authors.forename: P C
authors.initials: PC
authors.lastname: Laussen
mesh_terms: D002315:Cardiopulmonary Bypass / Q000009:adverse effects; D020345:Enterocolitis, Necrotizing / Q000150:complications / Q000628:therapy; D015199:Extracorporeal Membrane Oxygenation; D006330:Heart Defects, Congenital / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D007231:Infant, Newborn; D011182:Postoperative Care; D011183:Postoperative Complications; D011379:Prognosis