title: Pharmacokinetics of metformin gastric-retentive tablets in healthy volunteers.
abstract: The single-dose pharmacokinetics of two gastric-retentive, extended-release tablet formulations of metformin hydrochloride in fed, healthy volunteers were compared with those of the currently marketed immediate-release metformin hydrochloride product. The plasma concentration-time profiles demonstrated extended-release characteristics from the gastric-retentive tablets. The mean bioavailability from each gastric-retentive tablet was approximately 115%, relative to the immediate-release (IR) product. Cmax values were lower and tmax values were greater for the gastric-retentive tablets compared with the IR product. In contrast to conventional extended-release metformin tablets reported in the literature, these gastric-retentive tablets showed extended-release plasma concentration profiles of metformin hydrochloride and increased bioavailability compared with the immediate-release tablet.
authors.affiliation: DepoMed, Inc., 1360 O'Brien Drive, Menlo Park, CA 94025-1436, USA.
authors.forename: G
authors.initials: G
authors.lastname: Gusler
authors.forename: J
authors.initials: J
authors.lastname: Gorsline
authors.forename: G
authors.initials: G
authors.lastname: Levy
authors.forename: S Z
authors.initials: SZ
authors.lastname: Zhang
authors.forename: I E
authors.initials: IE
authors.lastname: Weston
authors.forename: D
authors.initials: D
authors.lastname: Naret
authors.forename: B
authors.initials: B
authors.lastname: Berner
mesh_terms: D000328:Adult; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D018592:Cross-Over Studies; D004304:Dosage Forms; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics; D008687:Metformin / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*
chemical_list: D004304:Dosage Forms; D007004:Hypoglycemic Agents; D008687:Metformin