title: A new method for chemoselective conjugation of unprotected peptides to dauno- and doxorubicin.
abstract: A new approach for chemoselective ligation of peptides to dauno- and doxorubicin through an oxime bond is presented. The method does not require protecting groups on the peptide moiety.
authors.affiliation: Istituto di Ricerche di Biologia Molecolare P. Angeletti, Pomezia, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Ingallinella
authors.forename: A D
authors.initials: AD
authors.lastname: Marco
authors.forename: M
authors.initials: M
authors.lastname: Taliani
authors.forename: D
authors.initials: D
authors.lastname: Fattori
authors.forename: A
authors.initials: A
authors.lastname: Pessi
mesh_terms: D000595:Amino Acid Sequence; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D003630:Daunorubicin / Q000737:chemistry*; D004317:Doxorubicin / Q000737:chemistry*; D016503:Drug Delivery Systems / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000970:Antineoplastic Agents; D010455:Peptides; D004317:Doxorubicin; D003630:Daunorubicin