Highly enantioselective hydrogenation of (E)-beta-(acylamino)acrylates catalyzed by Rh(i)-complexes of electron-rich P-chirogenic diphosphines.
Excellent enantioselectivities up to 99.7% were achieved in the hydrogenation of (E)-beta-(acylamino)acrylates by the use of Rh(I)-complexes of electron-rich diphosphines, t-Bu-BisP and t-Bu-MiniPHOS. Low-temperature NMR experiments testify that monohydrides with beta-carbon atom of the substrate bound to rhodium are involved in the catalytic cycle.
Yasutake
M
M
Department of Chemistry, Faculty of Science, Chiba University, Chiba 263-8522, Japan.
Gridnev
I D
ID
Higashi
N
N
Imamoto
T
T
D000179:Acrylates / Q000737:chemistry*; D002384:Catalysis; D004583:Electrons; D006865:Hydrogenation; D009682:Magnetic Resonance Spectroscopy; D010720:Phosphines / Q000737:chemistry*; D013237:Stereoisomerism
D000179:Acrylates; D010720:Phosphines