Epstein-Barr Virus and HLA-DPB1-*0301 in young adult Hodgkin's disease: evidence for inherited susceptibility to Epstein-Barr Virus in cases that are EBV(+ve).
Cases of Hodgkin's disease (HD) may be distinguished by whether they do [EBV-positive ((+ve)) cases] or do not [EBV-negative ((-ve)) cases] have evidence of EBV DNA in the Reed-Sternberg cells. Only one study has attempted to distinguish epidemiological risk factors for EBV(+ve) and EBV(-ve) HD, and none have compared inherited susceptibility. The present study involves a population-based case series of HD, diagnosed in patients between 16-24 years of age in the United Kingdom (n = 118), of whom 87% were classified by EBV status (EBV(+ve), 19, EBV(-ve), 84). History of infectious illness, EBV antibody titers, and HLA-DPB1 type have been compared in EBV(+ve) and EBV(-ve) cases. Reported infectious mononucleosis was more frequent in EBV(+ve) cases (odds ratio (OR), 5.10; 95% confidence interval (CI), 1.12-24.4). EBV antibody titers to viral capsid antigen were significantly higher in EBV(+ve) cases (P for trend = 0.02). Higher proportions of EBV(+ve) (43%) than EBV(-ve) (31%) cases typed positive for HLA-DPB1*0301, but this was not statistically significant; the association of infectious mononucleosis with EBV(+ve) cases was stronger in this HLA subgroup (OR, 17.1; 95%CI, 1.06-1177) than in other cases (OR, 1.24; 95% CI, 0.02-15.4). Although these results are based on small numbers of HD cases, they provide suggestive evidence that the etiology of EBV(+ve) HD may involve inherited susceptibility to EBV.
Alexander
F E
FE
Department of Community Health Sciences, University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom.
Jarrett
R F
RF
Cartwright
R A
RA
Armstrong
A A
AA
Gokhale
D A
DA
Kane
E
E
Gray
D
D
Lawrence
D J
DJ
Taylor
G M
GM
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016021:Epidemiologic Studies; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D020022:Genetic Predisposition to Disease; D006682:HLA-DP Antigens / Q000032:analysis*; D059868:HLA-DP beta-Chains; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000472:pathogenicity*; D006689:Hodgkin Disease / Q000235:genetics / Q000276:immunology* / Q000821:virology*; D006801:Humans; D008297:Male; D012307:Risk Factors
D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen