title: Fragrance contact dermatitis: a worldwide multicenter investigation (Part II).
abstract: The purpose of this study was to determine the frequency of responses to selected fragrance materials in patients who were fragrance sensitive. 178 patients were evaluated in 8 centers worldwide with a fragrance mix (FM) and 20 other fragrance materials. Reaction to the fragrance mixture (FM) occurred in 78.7% of the subjects. Substances reacting at a rate of 2% or higher included jasmine absolute, geranium oil bourbon, l-citronellol, spearmint oil, 1,3,4,6,7,8-hexahydro-4,6,6,7,8,8-hexamethylcyclopenta-gamma-2-benzopyran, omega-6-hexadecenlactone, dimethyltetrahydrobenzaldehyde (isomer mixture), and alpha-amylcinnamaldehyde. These chemicals should be furthur evaluated to corroborate their allergenicity. We are constantly looking for new fragrance allergens to extend the diagnostic capability of the fragrance mix (FM).
authors.affiliation: Portland, Oregon, USA.
authors.forename: W
authors.initials: W
authors.lastname: Larsen
authors.forename: H
authors.initials: H
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Fischer
authors.forename: P
authors.initials: P
authors.lastname: Elsner
authors.forename: P
authors.initials: P
authors.lastname: Frosch
authors.forename: D
authors.initials: D
authors.lastname: Burrows
authors.forename: W
authors.initials: W
authors.lastname: Jordan
authors.forename: S
authors.initials: S
authors.lastname: Shaw
authors.forename: J
authors.initials: J
authors.lastname: Wilkinson
authors.forename: J
authors.initials: J
authors.lastname: Marks
authors.forename: M
authors.initials: M
authors.lastname: Sugawara
authors.forename: M
authors.initials: M
authors.lastname: Nethercott
authors.forename: J
authors.initials: J
authors.lastname: Nethercott
mesh_terms: D000485:Allergens / Q000009:adverse effects / Q000737:chemistry; D017449:Dermatitis, Allergic Contact / Q000209:etiology*; D006801:Humans; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects* / Q000737:chemistry; D012680:Sensitivity and Specificity
chemical_list: D000485:Allergens; D010476:Perfume