IL-5 production by peripheral blood Th cells of adult asthma patients in response to Candida albicans allergen.
Cytokines produced by T cells are involved in chronic asthma. Relevant antigens for nonatopic asthma are still mostly unknown. Peripheral blood mononuclear cells (PBMCs) were obtained from adult asthmatic donors and incubated with Candida albicans extract. Proliferation response and cytokine production were analyzed. IL-2 and IL-5 were detectable in the cultures incubated with C. albicans extract, whereas IL-4 was undetectable. PBMCs obtained from some nonatopic asthma patients produced IL-5 upon stimulation of C. albicans extract. C. albicans allergen may be involved in the airway eosinophilic inflammation through the induction of IL-5 production by Th cells.
Mori
A
A
Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital, Sagamihara, Kanagawa, Japan. mori-kkr@umin.ac.jp
Ikeda
Y
Y
Taniguchi
M
M
Aoyama
C
C
Maeda
Y
Y
Hasegawa
M
M
Kobayashi
N
N
Akiyama
K
K
D000328:Adult; D000485:Allergens / Q000276:immunology; D001249:Asthma / Q000276:immunology*; D001769:Blood / Q000276:immunology; D002176:Candida albicans / Q000276:immunology*; D002457:Cell Extracts / Q000494:pharmacology; D002478:Cells, Cultured; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D015848:Interleukin-5 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D011657:Pulmonary Eosinophilia / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*
D000485:Allergens; D002457:Cell Extracts; D015848:Interleukin-5