title: Impaired left ventricular filling due to right ventricular pressure overload in primary pulmonary hypertension: noninvasive monitoring using MRI.
abstract: OBJECTIVE
  To analyze the effect of primary pulmonary hypertension (PPH) on cardiac function using MRI.
  
  
  METHODS
  In 12 patients (9 women; age range, 30 to 56 years), the diagnosis of PPH had been established by catheterization (mean +/- SD pulmonary artery pressure [PAP] was 56 +/- 8 mm Hg). With breath-hold cine MRI, a series of short-axis images was acquired covering the whole left ventricle (LV) and right ventricle (RV). The curvature, defined as 1 divided by the radius of curvature in centimeters, was calculated for the septum and the LV free wall in early diastole. Leftward ventricular septal bowing (LVSB) is denoted by a negative curvature. For the LV and the RV, the end-diastolic volume (EDV), stroke volume (SV), and volumetric filling rate were calculated. The control subjects were all healthy (n = 14; 11 women; age range, 20 to 57 years).
  
  
  RESULTS
  In the patients, LVSB was quantified in early diastole by the septal curvature of - 0.14 +/- 0.07 cm(-1), and the septal to free-wall curvature ratio of - 0.42 +/- 0.21. LV EDV and LV SV correlated negatively with diastolic PAP (p = 0.004 and p = 0.04, respectively). In patients vs control subjects, RV SV was reduced (52 +/- 12 mL vs 82 +/- 11 mL, p < 0.0001); LV peak filling rate was smaller (2.2 +/- 0.7 EDV/s vs 3.3 +/- 0.5 EDV/s, p < 0.001); LV EDV was smaller (81 +/- 23 mL vs 117 +/- 19 mL, p = 0.001); and LV SV was smaller (49 +/- 18 mL vs 83 +/- 13 mL, p < 0.0001).
  
  
  CONCLUSIONS
  In PPH, RV pressure overload leads to LVSB and reduced RV output. By decreased blood delivery, LV filling is reduced, which results in decreased LV SV by the Frank-Starling mechanism.
authors.affiliation: Departments of Clinical Physics and Informatics, University Hospital Vrije Universiteit, Amsterdam, The Netherlands. jt.marcus@azvu.nl
authors.forename: J T
authors.initials: JT
authors.lastname: Marcus
authors.forename: A
authors.initials: A
authors.lastname: Vonk Noordegraaf
authors.forename: R J
authors.initials: RJ
authors.lastname: Roeleveld
authors.forename: P E
authors.initials: PE
authors.lastname: Postmus
authors.forename: R M
authors.initials: RM
authors.lastname: Heethaar
authors.forename: A C
authors.initials: AC
authors.lastname: Van Rossum
authors.forename: A
authors.initials: A
authors.lastname: Boonstra
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D013318:Stroke Volume; D018487:Ventricular Dysfunction, Left / Q000209:etiology*; D018497:Ventricular Dysfunction, Right / Q000503:physiopathology*