title: Effect of retinopathy of prematurity on resolution acuity development in 1- to 3-year-old children.
abstract: OBJECTIVE
  To assess the pattern of visual development in children aged 1-3 years with stage 1-3 retinopathy of prematurity (ROP).
  
  
  METHODS
  One hundred forty-four infants weighing <1500 g were divided into three groups according to ROP stage. Randomly chosen preterm infants were the controls. Ophthalmic examinations started 4-7 weeks after birth and were performed until the retina was fully vascularized or until any ROP that had developed resolved. Preferential looking acuity measurements were carried out at 12, 18, 24, and 36 months of age.
  
  
  RESULTS
  Infants with stage 1-2 or no ROP showed evidence of improving acuity development after 12 months. Infants with stage 3 ROP had significantly lower acuity scores compared to infants with stage 1-2 or no ROP at the 18- and 24-month follow-up examinations (P<.001). At 36 months, the visual acuity of infants with stage 3 ROP showed evidence of improving development but still lagged behind infants with stage 1-2 or no ROP.
  
  
  CONCLUSIONS
  Although mild ROP does not seem to have a considerable effect on the development of resolution acuity until age 3, severe forms of ROP may be associated with impaired visual development, which strongly suggests the necessity of periodic monitoring of early visual acuity in infants with ROP.
authors.affiliation: Department of Ophthalmology, Kobe University School of Medicine, and the Eye Clinic, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Dogru
authors.forename: H
authors.initials: H
authors.lastname: Shirabe
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Taoka
authors.forename: K
authors.initials: K
authors.lastname: Nomura
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D002675:Child, Preschool; D005260:Female; D005865:Gestational Age; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011446:Prospective Studies; D012178:Retinopathy of Prematurity / Q000145:classification / Q000503:physiopathology*; D015348:Vision, Binocular; D014792:Visual Acuity / Q000502:physiology*