Potentiation of antitumor effects of cisplatin by tumor necrosis factor-beta.
Recombinant tumor necrosis factor-beta potentiated the inhibitory effect of cisplatin on intramuscularly transplanted GA-1 tumor and liver metastasis in mice. The antitumor effect was related to cytotoxic and cytostatic activities of the test preparations rather than to initiation of apoptosis.
Sysoeva
G M
GM
Research Construction-and-Technology Institute of Biologically Active Substances, Vektor State Research Center, Novosibirsk, Siberia, Russia. nb@online.sinor.ru
Fadina
V A
VA
Popova
N A
NA
Nikitenko
E V
EV
Nikolin
V P
VP
Il'nitskaya
S I
SI
Kaledin
V I
VI
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017209:Apoptosis; D002945:Cisplatin / Q000627:therapeutic use*; D004357:Drug Synergism; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008233:Lymphotoxin-alpha / Q000627:therapeutic use*; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008938:Mitosis; D019042:Muscle Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D009368:Neoplasm Transplantation; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010545:Peroxides / Q000378:metabolism; D010587:Phagocytosis / Q000187:drug effects; D017382:Reactive Oxygen Species / Q000378:metabolism
D000970:Antineoplastic Agents; D008233:Lymphotoxin-alpha; D010545:Peroxides; D017382:Reactive Oxygen Species; D002945:Cisplatin