Synaptic P2X receptors.
Over the past two years, ATP has clearly been shown to act as a co-transmitter with GABA, glycine and probably glutamate in the central nervous system. Our understanding of the ATP-gated P2X receptors is progressing rapidly, and the pharmacology, stoichiometry and subunit combinations of heteropolymeric P2X channels has been substantially elucidated.
Robertson
S J
SJ
Academic Department of Neurosurgery, King's College London, Denmark Hill Campus, Bessemer Road, SE5 9PJ, London, UK. sue.robertson@kcl.ac.uk
Ennion
S J
SJ
Evans
R J
RJ
Edwards
F A
FA
D000200:Action Potentials / Q000502:physiology; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D001921:Brain / Q000502:physiology; D005544:Forecasting; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology; D007473:Ion Channels / Q000502:physiology; D008322:Mammals / Q000502:physiology; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D009457:Neuroglia / Q000187:drug effects / Q000502:physiology; D011493:Protein Kinase C / Q000502:physiology; D021122:Protein Subunits; D058910:Purinergic P2 Receptor Agonists; D051381:Rats; D018079:Receptors, GABA / Q000502:physiology; D017661:Receptors, Presynaptic / Q000187:drug effects / Q000502:physiology; D018048:Receptors, Purinergic P2 / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000502:physiology; D013329:Structure-Activity Relationship; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
D007473:Ion Channels; D009419:Nerve Tissue Proteins; D021122:Protein Subunits; D058910:Purinergic P2 Receptor Agonists; D018079:Receptors, GABA; D017661:Receptors, Presynaptic; D018048:Receptors, Purinergic P2; D011993:Recombinant Fusion Proteins; D000255:Adenosine Triphosphate; D011493:Protein Kinase C