Effect of centrally administered nitric oxide modulators in Brewer's yeast-induced nociception in rats.
Possible modulation of Brewer's yeast-induced nociception by centrally (icv) administered nitric oxide (NO) modulators, viz., NO synthase (NOS) inhibitors, NO precursor, donors, scavengers and co-administration of NO donor (SIN-1) with NOS inhibitor (L-NAME) and NO scavenger (Hb) was investigated in rats. Administration of NOS inhibitors and NO scavenger Hb increased the pain threshold capacity significantly, whereas NO donors SIN-1, SNP and NO precursor L-arginine were found to be hyperalgesic. D-arginine, the inactive isomer of L-arginine and methylene blue, inhibitor of soluble guanylate cyclase failed to alter the nociceptive behaviour in rats. Co-administration of SIN-1 with L-NAME and Hb found to increase the nociceptive threshold. The results indicate, that centrally administered NO modulators alter the nociceptive transmission induced by Brewer's yeast in rats.
Sarma
J
J
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar 243 122, India.
Tandan
S K
SK
Hajare
S W
SW
Kumar
D
D
Raviprakash
V
V
D000818:Animals; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism*; D020030:Nitric Oxide Donors / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010146:Pain / Q000139:chemically induced* / Q000209:etiology; D017288:Pain Threshold; D051381:Rats; D017208:Rats, Wistar; D012441:Saccharomyces cerevisiae
D004791:Enzyme Inhibitors; D020030:Nitric Oxide Donors; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase