title: Oxygen Radicals as Messengers in Oxygen-Dependent Gene Expression.
abstract: Changes in ambient PO(2) need to be sensed to allow long-term adaptation of cellular functions via the regulation of gene activity. The generation of OH* from H(2)O(2) in an iron-dependent perinuclear Fenton reaction for triggering gene expression could be the key event in the O(2) signaling pathway.
authors.affiliation: Institut für Biochemie und Molekulare Zellbiologie, Humboldtallee 23, 37073 Göttingen, Germany.
authors.forename: Thomas
authors.initials: T
authors.lastname: Kietzmann
authors.forename: Joachim
authors.initials: J
authors.lastname: Fandrey
authors.forename: Helmut
authors.initials: H
authors.lastname: Acker