Cyclosporine therapeutic and toxic effects may be related to different cyclosporine concentration zones in plasma.
Different cyclosporine concentration zones can exist in plasma due to the temperature dependency in distribution and association, therefore cyclosporine therapeutic and toxic effects may partially be related to these concentration zones.
Wu
G
G
Faculty of Pharmacy, University of Mediterranean, 27 Jean Moulin, Marseilles, Cedex 05, 13385, France.
Yan
S M
SM
D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood / Q000493:pharmacokinetics / Q000627:therapeutic use*; D006801:Humans
D016572:Cyclosporine