[The effect of L-arginine on the development of experimental cardiac hyperfunction and hypertrophy].
It was shown, in the investigation on laboratory rats with experimental aortic coarctation, the development of myocardial hyperfunction and hypertrophy before and under the influence of the N kappa--predecessor--L-arginine. It was found that on the 14-20 day after coarctation weight of the heart, especially of the left ventricle, and contractive activity of the papillar muscle realistically increase. Under durable infusion of L-arginine to the rats (100 mg/kg) with aortic coarctation, weight of heart and myocardial contractive activity increase more significantly than without it. N kappa--predecessor secures intracellular structures of the myocardium.
Lahodych
T S
TS
A. A. Bogomoletz National Medical University, Kiev.
Karvats'kyĭ
I M
IM
Shevchuk
V H
VH
D000818:Animals; D001017:Aortic Coarctation / Q000188:drug therapy* / Q000503:physiopathology; D001120:Arginine / Q000008:administration & dosage*; D006332:Cardiomegaly / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology*; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000166:cytology / Q000648:ultrastructure; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar
D001120:Arginine