title: Furomegistines I and II, two furanopyridine alkaloids from the bark of Sarcomelicope megistophylla.
abstract: Two alkaloids, furomegistine I (1) and furomegistine II (2), were isolated from the bark of Sarcomelicope megistophylla. Their structures have been elucidated on the basis of MS and NMR data. Both belong to the category of furanopyridine alkaloids and should be considered as oxidation products of a furo[2,3-b]quinoline precursor. The two alkaloids exhibited moderate cytotoxic activity.
authors.affiliation: Department of Pharmacy, University of Athens, Greece.
authors.forename: N
authors.initials: N
authors.lastname: Fokialakis
authors.forename: P
authors.initials: P
authors.lastname: Magiatis
authors.forename: N
authors.initials: N
authors.lastname: Aligiannis
authors.forename: S
authors.initials: S
authors.lastname: Mitaku
authors.forename: F
authors.initials: F
authors.lastname: Tillequin
authors.forename: T
authors.initials: T
authors.lastname: Sévenet
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D003110:Colonic Neoplasms / Q000188:drug therapy; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D020128:Inhibitory Concentration 50; D008175:Lung Neoplasms / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D018547:Plant Stems / Q000737:chemistry; D011725:Pyridines / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D015363:Quinolones / Q000737:chemistry*; D019685:Rosales / Q000737:chemistry*; D014197:Trees / Q000737:chemistry; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D001685:Biological Factors; D005663:Furans; D011725:Pyridines; D015363:Quinolones; C438048:furomegistine I; C438049:furomegistine II