title: Strip test for bedside detection of interleukin-6 in cervical secretions is predictive for impending preterm delivery.
abstract: Inflammatory cytokines in amniotic fluid are markers of prematurity which could characterize preterm labour of infectious origin. To avoid amniocentesis, we analyzed IL-6, IL-8, IL-10, and IL-13 by RT-PCR in cervical secretions (CS) of 307 women with preterm labour. IL-6 was detected in 26.3% patients who delivered at less than 34 weeks (specificity: 95.8%). In addition, IL-6 was associated with delivery within 7 days (specificity: 91.6%). To render the detection more rapid and cheaper, a strip test was designed and evaluated comparatively with RT-PCR in 76 women. This bedside strip test was twice more sensitive than RT-PCR, with little decrease in specificity.
authors.affiliation: Laboratoire d'Immunologie, Faculté Cochin, Université Paris-V, AP-HP, France.
authors.forename: H
authors.initials: H
authors.lastname: Trébéden
authors.forename: F
authors.initials: F
authors.lastname: Goffinet
authors.forename: G
authors.initials: G
authors.lastname: Kayem
authors.forename: F
authors.initials: F
authors.lastname: Maillard
authors.forename: E
authors.initials: E
authors.lastname: Lemoine
authors.forename: D
authors.initials: D
authors.lastname: Cabrol
authors.forename: B
authors.initials: B
authors.lastname: Weill
authors.forename: F
authors.initials: F
authors.lastname: Batteux
mesh_terms: D002584:Cervix Uteri / Q000378:metabolism*; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000378:metabolism; D007752:Obstetric Labor, Premature / Q000175:diagnosis*; D019095:Point-of-Care Systems; D011247:Pregnancy; D012333:RNA, Messenger / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012680:Sensitivity and Specificity
chemical_list: D015850:Interleukin-6; D012333:RNA, Messenger