title: Chamber properties from transmitral flow: prediction of average and passive left ventricular diastolic stiffness.
abstract: A chamber stiffness (K(LV))-transmitral flow (E-wave) deceleration time relation has been invasively validated in dogs with the use of average stiffness [(DeltaP/DeltaV)(avg)]. K(LV) is equivalent to k(E), the (E-wave) stiffness of the parameterized diastolic filling model. Prediction and validation of 1) (DeltaP/DeltaV)(avg) in terms of k(E), 2) early rapid-filling stiffness [(DeltaP/DeltaV)(E)] in terms of k(E), and 3) passive (postdiastasis) chamber stiffness [(DeltaP/DeltaV)(PD)] from A waves in terms of the stiffness parameter for the Doppler A wave (k(A)) have not been achieved. Simultaneous micromanometric left ventricular (LV) pressure (LVP) and transmitral flow from 131 subjects were analyzed. (DeltaP)(avg) and (DeltaV)(avg) utilized the minimum LVP-LV end-diastolic pressure interval. (DeltaP/DeltaV)(E) utilized DeltaP and DeltaV from minimum LVP to E-wave termination. (DeltaP/DeltaV)(PD) utilized atrial systolic DeltaP and DeltaV. E- and A-wave analysis generated k(E) and k(A). For all subjects, noninvasive-invasive relations yielded the following equations: k(E) = 1,401. (DeltaP/DeltaV)(avg) + 59.2 (r = 0.84) and k(E) = 229.0. (DeltaP/DeltaV)(E) + 112 (r = 0.80). For subjects with diastasis (n = 113), k(A) = 1,640. (DeltaP/DeltaV)(PD) - 8.40 (r = 0.89). As predicted, k(A) showed excellent correlation with (DeltaP/DeltaV)(PD); k(E) correlated highly with (DeltaP/DeltaV)(avg). In vivo validation of average, early, and passive chamber stiffness facilitates quantitative, noninvasive diastolic function assessment from transmitral flow.
authors.affiliation: Cardiovascular Biophysics Laboratory, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Lisauskas
authors.forename: J
authors.initials: J
authors.lastname: Singh
authors.forename: A W
authors.initials: AW
authors.lastname: Bowman
authors.forename: S J
authors.initials: SJ
authors.lastname: Kovács
mesh_terms: D000328:Adult; D003326:Coronary Circulation / Q000502:physiology*; D003971:Diastole; D004452:Echocardiography; D004548:Elasticity; D005260:Female; D005544:Forecasting; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000502:physiology*; D008955:Models, Cardiovascular; D011312:Pressure; D011859:Radiography; D013318:Stroke Volume; D016277:Ventricular Function, Left