Pharmacokinetics, urinary excretion and dosage regimen of diminazene in crossbred calves.
The pharmacokinetics, urinary excretion and dosage regimen of diminazene were investigated in crossbred male calves following a single intramuscular dose (3.5 mg x kg-1). Following intramuscular administration, the pharmacokinetics of diminazene was described with a one-compartment open model. The absorption rate constant and absorption half-life were 9.86 +/- 3.06 h-1 and 0.121 +/- 0.40 h, respectively. The value of elimination half-life was 107.5 +/- 8.50 h. The apparent volume of distribution was 0.74 +/- 0.07 L x kg-1. Systemic availability following intramuscular administration was 91.7%. Approximately 65% of the administered dose of diminazene was eliminated in the urine within 24 h of its intramuscular administration. Diminazene was bound to plasma proteins to the extent of approximately 32%. The satisfactory intramuscular dosage regimen of diminazene for calves would be 2.24 mg x kg-1 followed by 1.5 mg x kg-1 at 7 days.
Kaur
G
G
Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana-141004, India.
Chaudhary
R K
RK
Srivastava
A K
AK
D000818:Animals; D001682:Biological Availability; D002417:Cattle / Q000502:physiology*; D004133:Diminazene / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology; D006207:Half-Life; D007273:Injections, Intramuscular; D008297:Male; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology
D014344:Trypanocidal Agents; D004133:Diminazene