The use of functional genomics in C. elegans for studying human development and disease.
The 100 Mb Caenorhabditis elegans genome sequence is the first animal genome to be sequenced in its entirety. Many reverse-genetics tools have been developed to mine the genome sequence and to facilitate the jump between the identification of a gene sequence and the understanding of its function. Here we discuss how C. elegans can contribute to understanding of the function of genes involved in human development and disease.
Kuwabara
P E
PE
The Sanger Centre, Hinxton, UK. pek@sanger.ac.uk
O'Neil
N
N
D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D016678:Genome; D023281:Genomics; D006128:Growth / Q000502:physiology; D006801:Humans