title: Obstetrician-gynecologists performing genetic amniocentesis may be misleading themselves and their patients.
abstract: OBJECTIVE
  Our purpose was to compare midtrimester amniocentesis-related fetal loss rates between obstetrician-gynecologists and perinatologists.
  
  
  METHODS
  This cohort study analyzes 1384 midtrimester amniocenteses from January 1, 1996, to December 31, 1999. Obstetrician-gynecologists who split their practices between two or more hospitals and explained fetal losses (eg, fetal anomalies, aneuploidy) were excluded from analysis. Eight obstetrician-gynecologists performed 138 procedures; 3 perinatologists performed 1246 procedures. Three experienced obstetrician-gynecologists accounted for 113 procedures. Analysis was by chi2.
  
  
  RESULTS
  Within 30 days of midtrimester amniocentesis, there were 3 fetal losses for obstetrician-gynecologists and 4 for perinatologists (P =.02, chi2 = 5.19, degrees of freedom = 1). Obstetrician-gynecologist loss rates were 1 in 46 procedures versus 1 in 312 procedures for perinatologists. Losses were clustered among the 3 experienced obstetrician-gynecologists (P <.01, chi2 = 6.93, degrees of freedom = 1). The experienced obstetrician-gynecologist fetal loss rate was 1 in 38 amniocenteses, and the perinatologist fetal loss rate was 1 in 312.
  
  
  CONCLUSIONS
  The risk of fetal loss from midtrimester amniocentesis appears to be higher when performed by an obstetrician-gynecologist compared with a perinatologist.
authors.affiliation: Department of Obstetrics and Gynecology, Providence Hospital, Southfield, Michigan 48075, USA.
authors.forename: W B
authors.initials: WB
authors.lastname: Blessed
authors.forename: H
authors.initials: H
authors.lastname: Lacoste
authors.forename: R A
authors.initials: RA
authors.lastname: Welch
mesh_terms: D000649:Amniocentesis / Q000009:adverse effects*; D005260:Female; D005313:Fetal Death / Q000209:etiology*; D005820:Genetic Testing / Q000379:methods*; D006176:Gynecology / Q000379:methods*; D006801:Humans; D009774:Obstetrics / Q000379:methods*; D010500:Perinatology / Q000379:methods; D011247:Pregnancy; D011262:Pregnancy Trimester, Second