Therapeutic efficacy of oxime reactivators in fenitrothion toxicity in buffalo calves (Bubalus bubalis).
The therapeutic efficacy of 2-pyridine aldoxime methochloride and diacetylmonoxime (DAM) alone and in combination with atropine was determined in oral fenitrothion toxicity in buffalo calves. DAM alone and in combination with atropine constitute the most effective therapy of fenitrothion poisoning. As compared to 2-pyridine aldoxime methochloride, DAM was also more effective in reactivating the fenitrothion-inhibited erythrocyte and plasma acetylcholinesterase and serum carboxylesterase enzymes and reversing fenitrothion-induced hyperglycaemia, hyperproteinaemia and hypercreatinaemia in animals.
Srivastava
A K
AK
Department of Pharmacology and Toxicology, College of Veterinary Science, Punjab Agricultural University, Ludhiana-141 004, India.
Malik
J K
JK
D000110:Acetylcholinesterase / Q000097:blood; D000818:Animals; D000931:Antidotes / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D001798:Blood Proteins / Q000032:analysis; D002020:Buffaloes; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D003931:Diacetyl / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005278:Fenitrothion / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D010091:Oximes / Q000494:pharmacology*; D011041:Poisoning / Q000662:veterinary; D011897:Random Allocation
D000931:Antidotes; D001786:Blood Glucose; D001798:Blood Proteins; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D010091:Oximes; C004717:diacetylmonoxime; D001285:Atropine; C060977:pyridine-2-aldoxime; D003404:Creatinine; D000110:Acetylcholinesterase; D003931:Diacetyl; D005278:Fenitrothion