Pharmacological relapse prevention in alcohol dependence: from animal models to clinical trials.
This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were Jobst August-Ludwig Boening and Otto Michel Lesch. The presentations were (1) Pharmacological validation of a new animal model of alcoholism, by Rainer Spanagel; (2) Persisting loss of control as main criterion for alcohol addiction in rats and mice, by Jochen Wolffgramm; (3) Role of NMDA receptor subunits associated with protein kinase C in the prevention of alcohol dependence, by Minoru Narita; (4) Long-term follow up of continued naltrexone treatment, by David Sinclair; (5) Pharmacological treatment trials with dopaminergic and serotonergic substances: Myths or facts? by Gerhard A. Wiesbeck; and (6) Methodology and behavioral therapy of the U.S. acamprosate study, by Barbara J. Mason.
Boening
J A
JA
Department of Psychiatry, Addiction Medicine, University of Wuerzburg, Germany.
Lesch
O M
OM
Spanagel
R
R
Wolffgramm
J
J
Narita
M
M
Sinclair
D
D
Mason
B J
BJ
Wiesbeck
G A
GA
D000077443:Acamprosate; D000427:Alcohol Deterrents / Q000627:therapeutic use*; D000437:Alcoholism / Q000188:drug therapy* / Q000517:prevention & control; D000818:Animals; D002986:Clinical Trials as Topic / Q000379:methods; D004195:Disease Models, Animal; D015259:Dopamine Agents / Q000627:therapeutic use; D006801:Humans; D009271:Naltrexone / Q000627:therapeutic use*; D009292:Narcotic Antagonists / Q000627:therapeutic use*; D016548:Prosencephalon / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000378:metabolism; D055502:Secondary Prevention; D018490:Serotonin Agents / Q000627:therapeutic use; D013654:Taurine / Q000031:analogs & derivatives / Q000627:therapeutic use*
D000427:Alcohol Deterrents; D015259:Dopamine Agents; C121001:NR2B NMDA receptor; D009292:Narcotic Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; D018490:Serotonin Agents; D013654:Taurine; D009271:Naltrexone; D000077443:Acamprosate