title: Antinociceptive activity of Zizyphus spina-christi root bark extract.
abstract: The antinociceptive effect of the aqueous extract of Zizyphus spina-christi root bark was investigated in mice and rats. Acetic acid-induced writhing, formalin and thermal (hot plate) tests were used. The extract (50 and 100 mg/kg, i.p.) showed a dose-dependent analgesic effect in all the tests used. Its i.p. LD50 in mice was 2236.07 mg/kg.
authors.affiliation: Department of Pharmacology & Toxicology, National Institute for Pharmaceutical Research and Development, Idu Industrial Area, P.M.B. 21, Garki, Abuja, Nigeria.
authors.forename: B
authors.initials: B
authors.lastname: Adzu
authors.forename: S
authors.initials: S
authors.lastname: Amos
authors.forename: C
authors.initials: C
authors.lastname: Wambebe
authors.forename: K
authors.initials: K
authors.lastname: Gamaniel
mesh_terms: D019342:Acetic Acid; D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005557:Formaldehyde; D006358:Hot Temperature; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales
chemical_list: D000700:Analgesics; D010936:Plant Extracts; D005557:Formaldehyde; D019342:Acetic Acid