[Ionic currents responsible for activation of isolated retinal ganglion cells].
Ionic currents responsible for excitability of retinal ganglion cells (RGC) freshly isolated from eyes of adult rats were studied. Kutward potassium currents in RGC represented by populations of slow inactivating and non-inactivating currents. Inward sodium currents were completely blocked by extracellular application of 0.25 mM TTX. Calcium conductance in freshly isolated RGC has two components: low- and high-threshold. Extracellular application of nifedipine (10 mM) or Cd2+ (10 mM) blocked high threshold calcium currents by 28% and 60%, correspondingly, without any significant effect on low threshold calcium currents.
Veselovs'ka
N M
NM
Kiev Center of Eye Pathology, Kiev.
Veselovs'kyĭ
M S
MS
D000818:Animals; D002118:Calcium / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000502:physiology; D004558:Electric Stimulation; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009543:Nifedipine / Q000494:pharmacology; D015221:Potassium Channels / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012165:Retinal Ganglion Cells / Q000187:drug effects* / Q000502:physiology* / Q000648:ultrastructure; D015222:Sodium Channels / Q000502:physiology
D002121:Calcium Channel Blockers; D015220:Calcium Channels; D015221:Potassium Channels; D015222:Sodium Channels; D009543:Nifedipine; D002118:Calcium