Genetic association analysis of alpha-1-antichymotrypsin polymorphism in Parkinson's disease.
alpha(1)-Antichymotrypsin (ACT) gene has been suggested as a susceptibility factor for Parkinson's disease (PD) and might be related to the onset of PD. We replicated these findings in a Chinese population. The results demonstrated that the ACT genotypic and allelic distributions showed no significant differences between the PD patient and the control groups. The age at onset was younger in the heterozygotes than in the homozygotes (p = 0.042). We suggest that the ACT polymorphism might play some role in the pathogenesis of PD, especially in the onset.
Wang
Y C
YC
Section of Psychiatry, Yu-Li Veterans Hospital, Hualien, Taiwan, ROC.
Liu
H C
HC
Liu
T Y
TY
Hong
C J
CJ
Tsai
S J
SJ
D017668:Age of Onset; D000368:Aged; D044466:Asian People / Q000235:genetics*; D005260:Female; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000097:blood / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D000514:alpha 1-Antichymotrypsin / Q000097:blood / Q000235:genetics*
D000514:alpha 1-Antichymotrypsin