A case of giant extramammary Paget's disease of the genital area with squamous-cell carcinoma.
Extramammary Paget's disease is a primary carcinoma with apocrine differentiation that begins within the epidermis. Extramammary Paget's disease and squamous-cell carcinoma (SCC) have different neoplastic origins and are different both clinically and histologically. Until now the concurrence of extramammary Paget's disease and SCC in the same area has not been reported to our knowledge. We report on a 76-year-old man with extramammary Paget's disease affecting a large region of the genital area with SCC within the same area. A skin biopsy specimen showed the coexistence of typical Paget's disease and highly differentiated SCC invading the dermis. Immunohistochemical staining of both cell types was completely different.
Tanabe
H
H
Department of Dermatology, Tenri Hospital, Tenri City, Japan. h-tanabe@kanazawa-med.ac.jp
Kishigawa
T
T
Sayama
S
S
Tanaka
T
T
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology*; D005834:Genital Neoplasms, Male / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D018396:Mucin-1 / Q000032:analysis; D010145:Paget Disease, Extramammary / Q000378:metabolism / Q000473:pathology*; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*
D018396:Mucin-1