PPAR gamma: an essential role in metabolic control.
The peroxisome proliferator-activated receptor gamma is a nuclear hormone receptor playing a crucial role in adipogenesis and insulin sensitization. Prostaglandin J2 derivatives and the antidiabetic thiazolidinediones are its respective natural and synthetic ligands. The RXR/PPAR gamma heterodimer has also been reported to have important immunomodulatory activities and its pleiotropic functions suggest wide-ranging medical implications.
Fajas
L
L
Institut de Génétique et de Biologie Moléculaire et Cellulaire, CNRS, INSERM, ULP, Illkirch, France.
Debril
M B
MB
Auwerx
J
J
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology; D015870:Gene Expression; D006801:Humans; D007249:Inflammation / Q000209:etiology; D007328:Insulin / Q000502:physiology*; D008024:Ligands; D015230:Prostaglandin D2 / Q000031:analogs & derivatives* / Q000032:analysis; D018160:Receptors, Cytoplasmic and Nuclear / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D013844:Thiazoles; D045162:Thiazolidinediones; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism / Q000502:physiology*
D007328:Insulin; D008024:Ligands; D018160:Receptors, Cytoplasmic and Nuclear; D013844:Thiazoles; D045162:Thiazolidinediones; D014157:Transcription Factors; C037112:9-deoxy-delta-9-prostaglandin D2; C089946:2,4-thiazolidinedione; D015230:Prostaglandin D2