Encoding process in delayed recall impairment and rate of forgetting in Alzheimer's disease.
OBJECTIVE
To assess the role of impaired encoding in learning and in delayed recall disturbances, and to evaluate the rate of forgetting in AD.


METHODS
Fifteen AD patients with mild or moderate dementia and 15 normal matched controls were assessed with the Buschke Selective Reminding Test. Delayed recall was evaluated after 30 minutes and after 24 hours.


RESULTS
AD patients had a poorer performance across the six trials of the learning phase as well as in both delayed recall evaluations, with no difference between recall at 30 minutes and at 24 hours.


CONCLUSIONS
Performance in the learning phase was as specific and almost as sensitive as the performance in delayed recall for AD diagnosis. Encoding impairment was responsible for poorer learning and rapid displacement of previous learned material in the AD group. Finally, we did not find a higher rate of forgetting in AD patients.
Degenszajn
J
J
Behavioral and Cognitive Neurology Unit, Department of Neurology, School of Medicine, University of São Paulo, São Paulo, Brazil. jdegen@uol.com.br
Caramelli
P
P
Caixeta
L
L
Nitrini
R
R
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000523:psychology; D016022:Case-Control Studies; D003463:Cues; D005260:Female; D006801:Humans; D007858:Learning; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000209:etiology; D011939:Mental Recall; D009483:Neuropsychological Tests; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D018709:Statistics, Nonparametric