Dramatic response of teratoma-associated non--germ-cell cancer with all-trans retinoic acid in a patient with nonseminomatous germ cell tumor.
A patient with nonseminomatous germ cell cancer, treated with standard chemotherapy, subsequently developed a pathologically confirmed metastatic undifferentiated adenocarcinoma (non-germ-cell elements) arising from residual teratoma. Disease was present in both lobes of the liver and was deemed unresectable at the time of presentation. The patient was treated on a National Cancer Institute-sponsored institutional protocol with all-trans retinoic acid. After 60 days of oral therapy at a dose of 150 mg/m2/d (50 mg/m2 three times daily), the patient was found to have complete radiologic resolution of his hepatic metastases. He subsequently underwent surgery and his complete response was pathologically confirmed.
Gordon
M S
MS
Department of Medicine, Indiana University School of Medicine, Indianapolis, USA.
Battiato
L A
LA
Finch
D
D
Goulet
R
R
Einhorn
L H
LH
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D018237:Germinoma / Q000188:drug therapy*; D006801:Humans; D008297:Male; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D013724:Teratoma / Q000188:drug therapy*; D013736:Testicular Neoplasms / Q000188:drug therapy*; D014212:Tretinoin / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D014212:Tretinoin