Exuberant Ca(2+) Signaling in Neutrophils: A Cause for Concern.
Under inflammatory conditions after burn/trauma injuries, circulating neutrophils are frequently hyperactive, contributing to excessive superoxide production and related tissue damage. Although normal neutrophil activation is cooperatively controlled by Ca(2+)-independent and Ca(2+)-linked signaling pathways, exuberant Ca(2+)-linked signaling appears to cause neutrophil hyperactivation in the injury conditions.
Sayeed
Mohammed M.
MM
Departments of Physiology and Surgery and the Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, IL 60153.