title: Antiplatelet activity of N-methoxycarbonyl aporphines from Rollinia mucosa.
abstract: Bioassay-directed fractionation of the stems of Rollinia mucosa led to the isolation of new N-methoxycarbonyl aporphine alkaloids, romucosine A (1), romucosine B (2), romucosine C (3), and romucosine D (4), along with the known alkaloid, N-methoxylcarbonyl-nornuciferine (5). Alkaloids 1 and 4 exhibited significant inhibition of collagen, arachidonic acid, and platelet activating factor-induced platelet aggregation, and alkaloid 3 also showed an inhibitory effect on arachidonic acid induced platelet aggregation.
authors.affiliation: Graduate Institut of Natural Products, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors.forename: R Y
authors.initials: RY
authors.lastname: Kuo
authors.forename: F R
authors.initials: FR
authors.lastname: Chang
authors.forename: C Y
authors.initials: CY
authors.lastname: Chen
authors.forename: C M
authors.initials: CM
authors.lastname: Teng
authors.forename: H F
authors.initials: HF
authors.lastname: Yen
authors.forename: Y C
authors.initials: YC
authors.lastname: Wu
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001060:Aporphines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D021241:Spectrometry, Mass, Electrospray Ionization
chemical_list: D000470:Alkaloids; D001060:Aporphines; D010975:Platelet Aggregation Inhibitors