title: Investigations into the production and interconversion of phomoidrides A-D.
abstract: [structure: see text] Fermentation of ATCC 74256 led to the isolation and identification of C7 epimers of phomoidride A (CP-225,917) and phomoidride B (CP-263,114). We suggest the names phomoidrides C and D for these new fermentation products. Studies on the effect of pH on the distribution of phomoidrides A-D suggest phomoidride B (CP-263,114) is the first-formed secondary metabolite and the source of the remaining three phomoidrides.
authors.affiliation: Department of Chemistry, Texas A&M University, College Station, Texas 77842, USA.
authors.forename: P
authors.initials: P
authors.lastname: Spencer
authors.forename: F
authors.initials: F
authors.lastname: Agnelli
authors.forename: G A
authors.initials: GA
authors.lastname: Sulikowski
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D013186:Farnesyl-Diphosphate Farnesyltransferase / Q000037:antagonists & inhibitors; D051231:Farnesyltranstransferase; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D008299:Maleic Anhydrides / Q000737:chemistry* / Q000302:isolation & purification / Q000378:metabolism*; D015394:Molecular Structure; D013237:Stereoisomerism
chemical_list: C104959:CP 225917; C104957:CP 263114; D004791:Enzyme Inhibitors; D008299:Maleic Anhydrides; C438972:phomoidride C; C438971:phomoidride D; D019883:Alkyl and Aryl Transferases; D013186:Farnesyl-Diphosphate Farnesyltransferase; D051231:Farnesyltranstransferase