title: [Occurrence of congenital defects in the Czech Republic from 1996 to 1999 in the offspring of mothers taking medications during the 1st trimester of pregnancy].
abstract: OBJECTIVE
  Elaborate the results of recorded inborn defects in mothers taking drugs during the first trimester of pregnancy.
  
  
  METHODS
  Retrospective analysis of data from register of inborn defects in the Czech Republic.
  
  
  METHODS
  Elaboration of the incidence of selected types of inborn defects assessed in children born to mothers taking drugs during the first trimester of pregnancy. Data from the nationwide register of inborn defects kept in the Institute for Health Information and Statistics of the Czech Republic in 1996-1999 were used. From this total number 519 cases were recorded in born infants and 31 in foetuses. In born infants there were 215 affected girls and 304 affected boys. Some of the inborn defects were recorded more frequently in our material than in the remaining population.
  
  
  RESULTS
  In 1996-1999 in our retrospective analysis a total of 550 cases of inborn defects were recorded in women taking medication during the first trimester of pregnancy.
  
  
  CONCLUSIONS
  The paper presents recent results of the incidence of nationwide registration of inborn defects during a four-year period.
authors.affiliation: Ustav pro péci o matku a dítĕ, Praha-Podolí.
authors.forename: A
authors.initials: A
authors.lastname: Sípek
authors.forename: P
authors.initials: P
authors.lastname: Velebil
authors.forename: V
authors.initials: V
authors.lastname: Gregor
authors.forename: D
authors.initials: D
authors.lastname: Masátová
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000453:epidemiology*; D018153:Czech Republic / Q000453:epidemiology; D064420:Drug-Related Side Effects and Adverse Reactions; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011261:Pregnancy Trimester, First