title: Treatment of osteochondral injuries. Genetic engineering.
abstract: Articular cartilage injuries are commonly encountered problems in sports medicine and orthopaedics. The treatment of chondral and osteochondral lesions, which possess only a very limited potential for healing, still represents a great challenge to clinicians and to scientists. Experimental investigations reported over the last 20 years have shown that a variety of methods, including implantation of periosteum, perichondrium, artificial matrices, growth factors, and transplanted cells, can stimulate formation of new cartilage. Genetic engineering--a combination of gene transfer techniques and tissue engineering--will facilitate new approaches to the treatment of articular cartilage injuries.
authors.affiliation: Department of Orthopaedic Surgery, University of Pittsburgh, Pennsylvania, USA.
authors.forename: V
authors.initials: V
authors.lastname: Martinek
authors.forename: F H
authors.initials: FH
authors.lastname: Fu
authors.forename: C W
authors.initials: CW
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Huard
mesh_terms: D001672:Biocompatible Materials / Q000627:therapeutic use; D002358:Cartilage, Articular / Q000293:injuries* / Q000503:physiopathology / Q000637:transplantation; D019902:Chondrocytes / Q000502:physiology / Q000637:transplantation; D020219:Chondrogenesis / Q000502:physiology; D005109:Extracellular Matrix / Q000637:transplantation; D015316:Genetic Therapy / Q000295:instrumentation / Q000379:methods* / Q000639:trends; D006133:Growth Substances / Q000627:therapeutic use; D006801:Humans; D007718:Knee Injuries / Q000628:therapy*; D007719:Knee Joint / Q000503:physiopathology*; D033581:Stem Cell Transplantation; D014182:Transplantation, Autologous; D014945:Wound Healing / Q000502:physiology
chemical_list: D001672:Biocompatible Materials; D006133:Growth Substances