title: Methamphetamine increases expression of the apoptotic c-myc and L-myc genes in the mouse brain.
abstract: To clarify the possible mechanisms by which the recreational drug, methamphetamine (METH), induces apoptosis, we investigated its effects on the expression of Myc apoptotic genes. This paper presents the characterization of c-myc and L-myc gene transcription in the striatum and the cortex. In addition, the expression of the corresponding proteins was also evaluated. Our observations reveal that c-myc and L-myc were up-regulated by METH at both the mRNA and protein levels. Thus, myc transcription factors might be responsible for some aspects of METH-induced apoptotic processes.
authors.affiliation: Molecular Neuropsychiatry Section, National Institute on Drug Abuse-Intramural Research Program, Baltimore, MD 21224, USA.
authors.forename: N
authors.initials: N
authors.lastname: Thiriet
authors.forename: S
authors.initials: S
authors.lastname: Jayanthi
authors.forename: M
authors.initials: M
authors.lastname: McCoy
authors.forename: B
authors.initials: B
authors.lastname: Ladenheim
authors.forename: J L
authors.initials: JL
authors.lastname: Cadet
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects* / Q000235:genetics; D015153:Blotting, Western; D001923:Brain Chemistry / Q000187:drug effects* / Q000235:genetics; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D015870:Gene Expression / Q000187:drug effects; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D016271:Proto-Oncogene Proteins c-myc / Q000032:analysis / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D000697:Central Nervous System Stimulants; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; D008694:Methamphetamine