title: Effect of auditory cortex lesions on NADPH-diaphorase staining in the inferior colliculus of rat.
abstract: Projections from the auditory cortex (AC) in the rat terminate in the dorsal cortex (DC) and in the external cortex (EC) of the inferior colliculus (IC), areas which exhibit a moderate number of nicotinamide-adenine dinucleotide phosphate-diaphorase (NADPH-d) positive neurons. NADPH-d co-localizes with nitric oxide synthase, which is responsible for the production of the transcellular messenger, nitric oxide. Changes in NADPH-d staining in the IC were found after unilateral lesions of the AC. Lesions resulted in a reduction in NADPH-d staining in neurons and neuropil within the ipsilateral DC and EC with the maximum reduction occurring 3-4 days after lesion. The reduction in NADPH-d staining in the contralateral IC was less pronounced. Lesions affecting auditory areas Te 1 and Te 3 produced the largest decrease in NADPH-d staining in neurons and neuropil. This finding may be related to the abolition of the influence of glutamatergic corticocollicular and commissural pathways.
authors.affiliation: Department of Functional Anatomy 2nd Medical Faculty, Charles University, Prague, Czech Republic.
authors.forename: R
authors.initials: R
authors.lastname: Druga
authors.forename: J
authors.initials: J
authors.lastname: Syka
mesh_terms: D000818:Animals; D001303:Auditory Cortex / Q000503:physiopathology*; D001927:Brain Diseases / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*; D006651:Histocytochemistry / Q000379:methods; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology; D019581:Neuropil / Q000201:enzymology; D051381:Rats; D020318:Rats, Long-Evans; D012016:Reference Values; D013194:Staining and Labeling
chemical_list: D009252:NADPH Dehydrogenase