Increased plasma neurotensin concentrations in patients with Parkinson's disease.
Plasma neurotensin (NT) was measured by radioimmunoassay in propanol extracted and unextracted plasma from 16 parkinsonian patients (four before treatment) and 16 age and sex matched controls. Mean plasma NT concentrations were consistently higher in parkinsonian patients than in controls and higher in the four untreated patients than in levodopa treated patients suggesting that plasma NT measurement may represent an easy detectable additional index in diagnosing parkinsonism and provides a novel approach to research in this field.
Schimpff
R M
RM
INSERM U 339, Hôpital Saint Antoine, 184 rue du Faubourg, St Antoine, 75012 Paris, France.
Avard
C
C
Fénelon
G
G
Lhiaubet
A M
AM
Tennezé
L
L
Vidailhet
M
M
Rostène
W
W
D000368:Aged; D002853:Chromatography, Liquid / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009496:Neurotensin / Q000097:blood*; D010300:Parkinson Disease / Q000097:blood*
D009496:Neurotensin