title: Prospective study on plasma clotting parameters in diabetic children--no evidence for specific changes in coagulation system.
abstract: In a prospective study, clotting parameters of 37 children and adolescents with insulin-dependent diabetes mellitus (type 1 diabetes) were compared with those of a healthy control group. In a longitudinal follow-up over two years we found no statistical difference for most of the coagulation parameters investigated, including single factor analysis and coagulation inhibitors. The duration of type 1 diabetes was of no influence on these parameters. The only difference we found between patients and healthy controls was an elevation of PAI-1 in diabetics: median for PAI-1: 2.12 IU/ml in diabetics (range 0.50-8.40 IU/ml) and 0.84 IU/ml in normal controls (range 0.50-1.78 IU/ml). This difference was of statistic significance (p < 0.002) and also found in newly diagnosed patients. During observation time, none of our patients developed thrombosis or signs of vascular disease. In conclusion, we could not confirm the development of a hyper-coagulable state in pediatric diabetics, as it is described for adults with type 1 diabetes mellitus.
authors.affiliation: Department of Pediatrics, University of Würzburg, Würzburg, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Zeitler
authors.forename: A
authors.initials: A
authors.lastname: Thiede
authors.forename: H L
authors.initials: HL
authors.lastname: Müller
mesh_terms: D000293:Adolescent; D000990:Antithrombin III / Q000032:analysis; D001777:Blood Coagulation; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007223:Infant; D010314:Partial Thromboplastin Time; D010446:Peptide Fragments / Q000032:analysis; D010447:Peptide Hydrolases / Q000032:analysis; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011446:Prospective Studies; D011486:Protein C / Q000032:analysis; D017293:Protein S / Q000032:analysis; D011516:Prothrombin / Q000032:analysis; D011517:Prothrombin Time
chemical_list: D010446:Peptide Fragments; D017395:Plasminogen Activator Inhibitor 1; D011486:Protein C; D017293:Protein S; C046193:antithrombin III-protease complex; C045879:prothrombin fragment 1.2; D000990:Antithrombin III; D011516:Prothrombin; D005340:Fibrinogen; D010447:Peptide Hydrolases