title: [Use of the acoustic startle response in the mouse to evaluate the pharmacodynamic action of ethanol].
abstract: A method of the pharmacological screening of psychotropic drugs that is based on the estimation of the peak amplitude and latency of the acoustic startle response (ASR) is suggested. A linear relationship between the changes of the ASR parameters induced by acute i.p. 14C-ethanol administration and its contents in brain is demonstrated. It is proposed that changes of the ASR parameters are strictly dependent upon the concentration of a modulatory drug in the biophase of action (brain, serum) and therefore can be utilised for the effector analysis of pharmacokinetics and preliminary screening of psychotropic drugs.
authors.affiliation: A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
authors.forename: M V
authors.initials: MV
authors.lastname: Kopanytsia
authors.forename: H B
authors.initials: HB
authors.lastname: Vasylinin
authors.forename: O A
authors.initials: OA
authors.lastname: Fedorova
authors.forename: V P
authors.initials: VP
authors.lastname: Chekhovs'kyĭ
authors.forename: O V
authors.initials: OV
authors.lastname: Zhuk
authors.forename: V H
authors.initials: VH
authors.lastname: Zin'kovs'kyĭ
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D000431:Ethanol / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D013216:Reflex, Startle / Q000187:drug effects*
chemical_list: D002250:Carbon Radioisotopes; D002492:Central Nervous System Depressants; D011619:Psychotropic Drugs; D000431:Ethanol