title: Evidence for cure of 'young' men with prostate cancer.
abstract: A study was undertaken to evaluate the question of cure in "young" men with prostate cancer treated by external-beam radiation. Results in young men (< or = 65 years) were compared to older men. Biochemical freedom from failure was examined to 10 years' follow-up, and hazard functions for failure vs time were reported. Results show that prostate cancer patients are cured by external-beam radiation and that there is no difference in results for young or older men. Few failures occur after 5 years' follow-up and the percentage cured is similar to that with prostatectomy, with much less morbidity. Appropriate dose is necessary to optimize outcome.
authors.affiliation: Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. GE_Hanks@fccc.edu
authors.forename: G E
authors.initials: GE
authors.lastname: Hanks
authors.forename: A L
authors.initials: AL
authors.lastname: Hanlon
authors.forename: E M
authors.initials: EM
authors.lastname: Horwitz
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D003672:Defecation; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D007422:Intestines / Q000502:physiology; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods; D020018:Sexual Dysfunctions, Psychological / Q000523:psychology; D011795:Surveys and Questionnaires; D017211:Treatment Failure; D001743:Urinary Bladder / Q000502:physiology
chemical_list: D017430:Prostate-Specific Antigen