title: Hyperkeratosis lenticularis perstans (Flegel's disease)--lack of response to treatment with tacalcitol and calcipotriol.
abstract: Hyperkeratosis lenticularis perstans (HLP) or Flegel's disease is a rare dermatosis characterized by asymptomatic hyperkeratotic papules predominantly located on the lower extremities. Lesional and non-lesional epidermis samples were studied by light- and electron-microscopic examination. The main ultrastructural finding was the presence of structurally altered Odland bodies/membrane-coating granules. Different therapeutic options for HLP have been reported, but none of the treatments was shown to be consistently effective. Here, we report on a patient with Flegel's disease who did respond to topical 5-fluorouracil, whereas topical vitamin D(3) synthetics were ineffective.
authors.affiliation: Department of Dermatology, Eberhard Karl University, Tübingen, Germany. hans-juergen.blaheta@med.uni-tuebingen.de
authors.forename: H J
authors.initials: HJ
authors.lastname: Blaheta
authors.forename: G
authors.initials: G
authors.lastname: Metzler
authors.forename: G
authors.initials: G
authors.lastname: Rassner
authors.forename: C
authors.initials: C
authors.lastname: Garbe
mesh_terms: D002117:Calcitriol / Q000031:analogs & derivatives / Q000627:therapeutic use; D003879:Dermatologic Agents / Q000627:therapeutic use; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007642:Keratosis / Q000188:drug therapy / Q000473:pathology*; D007868:Leg Dermatoses / Q000188:drug therapy / Q000473:pathology*; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure; D016896:Treatment Outcome
chemical_list: D003879:Dermatologic Agents; D004100:Dihydroxycholecalciferols; C055085:calcipotriene; C023850:1 alpha,24-dihydroxyvitamin D3; D002117:Calcitriol