Evidence for cure of 'young' men with prostate cancer.
A study was undertaken to evaluate the question of cure in "young" men with prostate cancer treated by external-beam radiation. Results in young men (< or = 65 years) were compared to older men. Biochemical freedom from failure was examined to 10 years' follow-up, and hazard functions for failure vs time were reported. Results show that prostate cancer patients are cured by external-beam radiation and that there is no difference in results for young or older men. Few failures occur after 5 years' follow-up and the percentage cured is similar to that with prostatectomy, with much less morbidity. Appropriate dose is necessary to optimize outcome.
Hanks
G E
GE
Department of Radiation Oncology, Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA. GE_Hanks@fccc.edu
Hanlon
A L
AL
Horwitz
E M
EM
D000328:Adult; D000367:Age Factors; D000368:Aged; D003672:Defecation; D004307:Dose-Response Relationship, Radiation; D005500:Follow-Up Studies; D006801:Humans; D007422:Intestines / Q000502:physiology; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000532:radiotherapy*; D020266:Radiotherapy, Conformal / Q000009:adverse effects / Q000379:methods; D020018:Sexual Dysfunctions, Psychological / Q000523:psychology; D011795:Surveys and Questionnaires; D017211:Treatment Failure; D001743:Urinary Bladder / Q000502:physiology
D017430:Prostate-Specific Antigen