title: Extramedullary plasmacytoma of the parotid gland. Report of a case with extensive amyloid deposition masking the cytologic and histopathologic picture.
abstract: BACKGROUND
  Extramedullary plasmacytomas are uncommon. Although approximately 90% occur in the head and neck region, parotid gland localization is extremely rare.
  
  
  METHODS
  This report describes fine needle aspiration and histopathologic findings in an extramedullary plasmacytoma arising in the left parotid gland of a 62-year-old man. Aspiration smears showed multiple amorphous clumps of material admixed with ductal epithelial cells, multinucleated giant cells and inflammatory cells rich in plasma cells, suggestive of pleomorphic adenoma. In surgical material, excessive amyloid deposition was observed. Six months later the tumor recurred, and in the second surgical specimen clusters of atypical plasma cells among amyloid deposits was noted. Clinical and laboratory examination excluded multiple myeloma. After local recurrence, radiotherapy was applied. Ten months later the patient was well and without systemic involvement.
  
  
  CONCLUSIONS
  Two points are important. First, in the salivary gland region, because of the focal metachromasia of amyloid with Giemsa stain, amyloid can be confused with the chondromyxoid matrix of pleomorphic adenoma. Second, although localized forms of amyloid tumor exist, one should keep in mind that amyloid may be so abundant that it may mask an underlying plasma cell neoplasm, as in our case.
authors.affiliation: Department of Pathology, Medical Faculty, Kocaeli University, and the Departments of Pathology and Internal Medicine, Izmir Atatürk Training Hospital, Izmir, Turkey. hasanustun@netscape.net
authors.forename: M O
authors.initials: MO
authors.lastname: Ustün
authors.forename: N
authors.initials: N
authors.lastname: Ekinci
authors.forename: B
authors.initials: B
authors.lastname: Payzin
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology; D000686:Amyloidosis / Q000150:complications* / Q000473:pathology; D001707:Biopsy, Needle; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000473:pathology; D010307:Parotid Neoplasms / Q000150:complications / Q000473:pathology*; D010954:Plasmacytoma / Q000150:complications / Q000473:pathology*