title: Proposal of standardization on screening tests for detection of distant metastases from head and neck cancer.
abstract: A standardized approach to screening for distant metastases must be flexible. This reflects the fact that the issues involved have not been adequately studied to allow evidence-based recommendations. Effective and responsible application of screening for distant metastasis would improve our ability to council patients regarding important therapeutic decisions. It would also have important consequences on healthcare economics. Screening recommendations should reflect the stage of the primary tumor and the histologic cell type because these two parameters most clearly correlate with the risk for distant metastases. The most commonly encountered distant metastases are pulmonary. The most sensitive validated screening technique is just computed tomography (CT). Advanced technologies such as simultaneous positron emission tomography/CT may replace these prior technologies in the near future. Recommendations for routine screening following curative treatment are subjective at this time. Careful history and physical examination remains the basis for the follow-up evaluation. The sensitivity and cost effectiveness of imaging studies in this setting remains unstudied and contentious.
authors.affiliation: Department of Otolaryngology, University of Pittsburgh, PA 15213, USA. jonasj@pitt.edu
authors.forename: J T
authors.initials: JT
authors.lastname: Johnson
mesh_terms: D006258:Head and Neck Neoplasms / Q000473:pathology / Q000517:prevention & control*; D006801:Humans; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D014055:Tomography, Emission-Computed; D014057:Tomography, X-Ray Computed