Rate of cognitive decline in AD is accelerated by the interleukin-1 alpha -889 *1 allele.
The reason for differences in rate of cognitive decline in AD is unknown. The interleukin-1 alpha (IL-1 alpha) -889 *2 allele is associated with increased risk for AD. Surprisingly, in a sample of 114 patients followed for an average of 3.8 years, individuals homozygous for the IL-1 alpha -889 *1 allele declined significantly more rapidly on the Mini-Mental State Examination than did others. There was no difference in rate of decline between patients with and without the APOE epsilon 4 allele. These results support the hypothesis that inflammation is important in the clinical course of AD.
Murphy
G M
GM
Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, CA 94305, USA. gmurphy@leland.stanford.edu
Claassen
J D
JD
DeVoss
J J
JJ
Pascoe
N
N
Taylor
J
J
Tinklenberg
J R
JR
Yesavage
J A
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology; D003072:Cognition Disorders / Q000235:genetics* / Q000276:immunology; D018450:Disease Progression; D005260:Female; D005838:Genotype; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D008297:Male; D011110:Polymorphism, Genetic
D007375:Interleukin-1