Glycoprotein Ia C807T polymorphism and risk of restenosis following coronary stenting.
Platelets are thought to contribute to development of restenosis following percutaneous coronary interventions. The glycoprotein Ia/IIa complex is a major platelet collagen receptor, its surface expression being influenced by two, linked single nucleotide polymorphisms (C807T and G873A) in the glycoprotein Ia gene. T807 is associated with increased expression of this integrin receptor. We assessed whether T807 is associated with an increased risk of restenosis in 1769 consecutive patients treated with coronary stenting. 6-month follow-up angiograms were available in 82.4% of the patients. C807T genotype distribution was CC in 35.8%, CT in 47.6% and TT in 16.6% of the patients. Restenosis (diameter stenosis > or =50% at follow-up angiography) occurred in 32.9% of CC, 31.5% of CT and 32.1% of TT patients (P=0.87). The rate of major adverse cardiac events (death, myocardial infarction or need of reintervention) within 1 yr was 21.6% for CC, 21.7% for CT and 21.2% for TT patients (P=0.98). Thus, carriage of the GP Ia T807 allele is not associated with an increased risk of restenosis or unfavorable late outcome following coronary artery stenting.
von Beckerath
N
N
Deutsches Herzzentrum München and 1. Medizinische Klinik rechts der Isar, Technische Universität München, Lazarettstr. 36, 80636, Munich, Germany. beckerath@dhm.mhn.de
Koch
W
W
Mehilli
J
J
Böttiger
C
C
Braun
S
S
Schömig
A
A
Kastrati
A
A
D000368:Aged; D001483:Base Sequence; D016001:Confidence Intervals; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy*; D005260:Female; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D016023:Integrins / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016017:Odds Ratio; D010973:Platelet Adhesiveness / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D038981:Receptors, Collagen; D012008:Recurrence; D018570:Risk Assessment; D012307:Risk Factors; D012680:Sensitivity and Specificity; D012720:Severity of Illness Index; D015607:Stents / Q000009:adverse effects*
D005819:Genetic Markers; D016023:Integrins; D038981:Receptors, Collagen