title: The ability of electrical measurements to predict skin moisturization. II. Correlation between one-hour measurements and long-term results.
abstract: We investigated the ability of short-term (one-hour) electrical measurements with three different commonly used instruments to predict the effects of long-term treatment with glycerin-containing formulations on moderately dry leg skin. We report the moisturizing effects of glycerin on healthy female adult skin in a two-week study as measured by electrical conductance and capacitance, transepidermal water loss (TEWL), and clinical grading of skin dryness. The test formulations contained 1.5% NaCl and levels of glycerin from 0% to 15%. Results obtained with a smaller cohort of ten subjects, one hour after treatment, were predictive of moisturizing efficacy in the two-week period among twenty subjects with dry leg skin. Our results show that single application tests can be predictive of longer-term results with humectant-based moisturizers and that electrical measurements of skin conditions correlate well with skin grades.
authors.affiliation: College of Pharmacy, University of Cincinnati, OH, USA.
authors.forename: F
authors.initials: F
authors.lastname: Li
authors.forename: E
authors.initials: E
authors.lastname: Conroy
authors.forename: M
authors.initials: M
authors.lastname: Visscher
authors.forename: R R
authors.initials: RR
authors.lastname: Wickett
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D004553:Electric Conductivity; D005260:Female; D005990:Glycerol / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology*; D013996:Time and Motion Studies; D014867:Water / Q000378:metabolism
chemical_list: D014867:Water; D012965:Sodium Chloride; D005990:Glycerol