title: The angiotensin I converting enzyme gene as a susceptibility factor for dementia.
abstract: The frequency of a genetic susceptibility vascular factor, the deletion (D) allele of the angiotensin I converting enzyme gene (ACE), coding for a key enzyme of the renin angiotensin system, was characterized in two independent case--control studies. The results of the current study suggest that bearing at least one ACE D allele is a risk factor to develop dementia for subjects older than 74 years. This observation reinforces the hypothesis of a major implication of vascular risk factors in the occurrence of all types of dementia.
authors.affiliation: INSERM Unité 508, Institut Pasteur de Lille, France.
authors.forename: F
authors.initials: F
authors.lastname: Richard
authors.forename: I
authors.initials: I
authors.lastname: Fromentin-David
authors.forename: F
authors.initials: F
authors.lastname: Ricolfi
authors.forename: P
authors.initials: P
authors.lastname: Ducimetière
authors.forename: C
authors.initials: C
authors.lastname: Di Menza
authors.forename: P
authors.initials: P
authors.lastname: Amouyel
authors.forename: N
authors.initials: N
authors.lastname: Helbecque
mesh_terms: D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003704:Dementia / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D012307:Risk Factors
chemical_list: D007703:Peptidyl-Dipeptidase A