title: Use of tissue plasminogen activator in a stroke after radiofrequency ablation of a left-sided accessory pathway.
abstract: We describe the case of a 12-year-old girl who had a thromboembolic stroke after radiofrequency ablation of a left posterior accessory pathway involving a transseptal procedure. Symptoms of a stroke occurred 7 hours 15 minutes after completion of the procedure. Tissue plasminogen activator (tPA) was given 2 hours 30 minutes after the onset of symptoms, with complete resolution of her neurologic symptoms. No adverse effects from the tPA were seen. Because of the late onset of symptoms in this case, overnight in-hospital observation is warranted for patients who undergo radiofrequency ablation of a left-sided accessory pathway or an accessory pathway in a patient with the ability to shunt right to left. In this case, tPA was an effective and safe drug to use following a cerebral thromboembolic event occurring after a cardiac catheterization procedure.
authors.affiliation: Texas Children's Hospital, Baylor College of Medicine, Houston, USA. bcannon@bcm.tmc.edu
authors.forename: B C
authors.initials: BC
authors.lastname: Cannon
authors.forename: N J
authors.initials: NJ
authors.lastname: Kertesz
authors.forename: R A
authors.initials: RA
authors.lastname: Friedman
authors.forename: A L
authors.initials: AL
authors.lastname: Fenrich
mesh_terms: D017115:Catheter Ablation / Q000009:adverse effects*; D002648:Child; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008943:Mitral Valve / Q000601:surgery; D010960:Plasminogen Activators / Q000627:therapeutic use*; D020521:Stroke / Q000188:drug therapy* / Q000209:etiology*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*; D014927:Wolff-Parkinson-White Syndrome / Q000628:therapy
chemical_list: D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator