Expression of IL-17 mRNA in ovarian cancer.
IL-17 is considered as a proinflammatory cytokine. We have demonstrated IL-17 is an angiogenic factor and promotes tumor growth in murine tumor models. In this report, we investigated the expression of IL-17 mRNA by RT-PCR and the relationship between IL-17 expression and microvascular density in ovarian cancer. IL-17 mRNA was expressed in 11 (64.7%) of 17 ovarian cancer. And the average number of blood vessels observed in IL-17 positive tumors (173.4 +/- 55.1/mm(2)) was significantly higher than that in negative tumors (107.7 +/- 57.8/mm(2)). These results indicated IL-17 is expressed in a considerable proportion of ovarian cancer and promotes tumor angiogenesis. There was no significant relationship between IL-17 expression and clinicopathologic parameters.
Kato
T
T
Department of Obstetrics and Gynecology, University of Tokushima, School of Medicine, 3-18-15 Kuramoto-cho, Tokushima, 770-8503, Japan.
Furumoto
H
H
Ogura
T
T
Onishi
Y
Y
Irahara
M
M
Yamano
S
S
Kamada
M
M
Aono
T
T
D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D020381:Interleukin-17 / Q000235:genetics*; D008833:Microcirculation / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000235:genetics; D010051:Ovarian Neoplasms / Q000098:blood supply / Q000235:genetics* / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics* / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000235:genetics* / Q000378:metabolism*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D017931:DNA Primers; D020381:Interleukin-17; D012333:RNA, Messenger; D012334:RNA, Neoplasm