title: Plasma Proteins Case Report: Massive Bone Marrow Necrosis with Polyclonal Hypergammaglobulinemia and Blue Toe Syndrome.
abstract: Massive bone marrow necrosis was rare, and most of these cases were accompanied with malignant disease. We report a case that was thought to be idiopathic massive bone marrow necrosis. It was a 58 y.o. male who was admitted because of blue toe syndrome and hypergammaglobulinemia. We tried to detect malignant diseases with computed tomography and gallium scintigraphy, and infectious diseases with bacterial culture and viral antibodies, but all of them were negative. Pancytopenia and bone marrow necrosis was not improved, and he had died after 5-month hospitalization. Autopsy revealed massive bone marrow necrosis and bone marrow fibrosis after necrosis, but malignant or infectious diseases were not detected. It may be diagnosed as idiopathic massive bone marrow necrosis.
authors.affiliation: Third Division, Department of Medicine, and.
authors.forename: TOHRU
authors.initials: T
authors.lastname: Murayama
authors.forename: YOSHITAKE
authors.initials: Y
authors.lastname: Hayashi
authors.forename: SHION
authors.initials: S
authors.lastname: Imoto
authors.forename: MANABU
authors.initials: M
authors.lastname: Shimoyama
authors.forename: HIROSHI
authors.initials: H
authors.lastname: Matsuoka
authors.forename: AKI
authors.initials: A
authors.lastname: Nagata
authors.forename: NOBUKO
authors.initials: N
authors.lastname: Iwata
authors.forename: TAIZO
authors.initials: T
authors.lastname: Taniguchi
authors.forename: MITSUHIRO
authors.initials: M
authors.lastname: Ito
authors.forename: HIROSHI
authors.initials: H
authors.lastname: Ito
authors.forename: KAZUO
authors.initials: K
authors.lastname: Chihara
authors.forename: TOSHIMITSU
authors.initials: T
authors.lastname: Matsui