title: In vitro cytotoxicity of flavonoids against MK2 and C6 tumour cells.
abstract: The cytotoxic effect of five flavonoids isolated from the aerial parts of the Asteraceae family of plants were studied in vitro using LLC-MK2 and C6 glial cells. Agehoustin A was shown to be cytotoxic for both cells (71% or 67% cell death). Agehoustin B and artemetin, which lack a methoxy group at C-8 (RI), were not cytotoxic for the cells (19% and 16% cell death). The three flavonoids showed considerable suppressive effects on LLC-MK2 and C6 cell growth. Lucidin-dimethylether and gnaphaliin were also not cytotoxic for cells but they had no suppressive effect on cell growth. The results show a structure-cytostatic activity relationship. We suggest that the methoxy group on C-8 and on the B ring are responsible for death cell.
authors.affiliation: Departamento Biología Molecular, Instituto de Investigaciones Biomédicas, UNAM, Circuito Interior, Ciudad Universitaria, Coyoacán 04510 México, D.F.
authors.forename: I
authors.initials: I
authors.lastname: Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Calderón
authors.forename: B
authors.initials: B
authors.lastname: Ruiz
authors.forename: J
authors.initials: J
authors.lastname: Tellez
authors.forename: L
authors.initials: L
authors.lastname: Calzada
authors.forename: J
authors.initials: J
authors.lastname: Taboada
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D019659:Asteraceae; D005419:Flavonoids / Q000633:toxicity*; D008251:Macaca; D010936:Plant Extracts / Q000633:toxicity; D018515:Plant Leaves; D010946:Plants, Medicinal; D051381:Rats; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D005419:Flavonoids; D010936:Plant Extracts