title: Dual and opposing modulatory effects of serotonin on crayfish lateral giant escape command neurons.
abstract: Serotonin modulates afferent synaptic transmission to the lateral giant neurons of crayfish, which are command neurons for escape behavior. Low concentrations, or high concentrations reached gradually, are facilitatory, whereas high concentrations reached rapidly are inhibitory. The modulatory effects rapidly reverse after brief periods of application, whereas longer periods of application are followed by facilitation that persists for hours. These effects of serotonin can be reproduced by models that involve multiple interacting intracellular signaling systems that are each stimulated by serotonin. The dependence of the neuromodulatory effect on dose, rate, and duration of modulator application may be relevant to understanding the effects of natural neuromodulation on behavior and cognition and to the design of drug therapies.
authors.affiliation: Department of Psychology, University of California, Los Angeles, Los Angeles, California 90095, USA.
authors.forename: T
authors.initials: T
authors.lastname: Teshiba
authors.forename: A
authors.initials: A
authors.lastname: Shamsian
authors.forename: B
authors.initials: B
authors.lastname: Yashar
authors.forename: S R
authors.initials: SR
authors.lastname: Yeh
authors.forename: D H
authors.initials: DH
authors.lastname: Edwards
authors.forename: F B
authors.initials: FB
authors.lastname: Krasne
mesh_terms: D000818:Animals; D003400:Astacoidea; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D004334:Drug Administration Schedule; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects* / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D017952:Ganglia, Invertebrate / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008959:Models, Neurological; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology*; D012684:Sensory Thresholds / Q000502:physiology; D012701:Serotonin / Q000008:administration & dosage* / Q000378:metabolism; D012815:Signal Processing, Computer-Assisted; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D012934:Social Isolation
chemical_list: D012701:Serotonin