Morphological and physiological characteristics of urethral circular and longitudinal smooth muscle.
The urethral wall contains circular and longitudinal smooth muscle. Both layers can develop spontaneous tone, and contract further or relax in response to excitatory or inhibitory stimuli. In the pig the cells do not generate action potentials, and the membranes possess L-type calcium channels and a variety of potassium channels which may modulate the membrane potential and tone. The importance of these layers in generating the urethral pressure is not well understood in the human, but it seems likely that the circular smooth muscle is involved in generating urethral pressure in the pig.
Brading
A F
AF
Oxford Continence Group, University Department of Pharmacology, UK.
Teramoto
N
N
Dass
N
N
McCoy
R
R
D000818:Animals; D004594:Electrophysiology; D006801:Humans; D008564:Membrane Potentials; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000033:anatomy & histology* / Q000502:physiology*; D014521:Urethra / Q000033:anatomy & histology* / Q000502:physiology*