The relationship of oxidative DNA damage marker 8-hydroxydeoxyguanosine and glycoxidative damage marker pentosidine.
OBJECTIVE
8-hydroxydeoxyguanosine (8-OHdG) is a biomarker of oxidative DNA damage. Pentosidine is a biomarker of glycoxidation reaction. In this study, we investigated relationships among 8-OHdG, pentosidine and age.


METHODS
We determined the urinary concentrations of 8-OHdG and pentosidine in adults with mild hypercholesterolemia or/and mild hypertension (hypercholesterolemia group, n = 31; hypertension group, n = 25; hypercholesterolemia and hypertension group, n = 7).


RESULTS
The strength of the relationship between 8-OHdG and age was the same as that between pentosidine and age (the correlation coefficient between 8-OHdG and age was 0.33, pentosidine and age was 0.37). In addition, there was a positive and significant correlation between 8-OHdG and pentosidine. On the other hand, mean values of 8-OHdG and pentosidine showed no significant difference among the three groups.


CONCLUSIONS
The results of the present study indicate that both 8-OHdG and pentosidine levels increase similarly in degenerative pathologic conditions.
Kouda
K
K
Department of Public Health, Hamamatsu University School of Medicine, Hamamatsu, Japan. kkouda@hama-med.ac.jp
Nakamura
H
H
Fan
W
W
Horiuchi
K
K
Takeuchi
H
H
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000328:Adult; D000368:Aged; D001120:Arginine / Q000031:analogs & derivatives* / Q000652:urine*; D004249:DNA Damage; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine*; D005260:Female; D017127:Glycation End Products, Advanced; D006801:Humans; D006937:Hypercholesterolemia / Q000652:urine; D006973:Hypertension / Q000652:urine; D008239:Lysine / Q000031:analogs & derivatives* / Q000652:urine*; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress
D017127:Glycation End Products, Advanced; D000080242:8-Hydroxy-2'-Deoxyguanosine; D001120:Arginine; C062187:pentosidine; D003849:Deoxyguanosine; D008239:Lysine