Cell transplantation as a treatment for retinal disease.
It has been shown that photoreceptor degeneration can be limited in experimental animals by transplantation of fresh RPE to the subretinal space. There is also evidence that retinal cell transplants can be used to reconstruct retinal circuitry in dystrophic animals. Here we describe and review recent developments that highlight the necessary steps that should be taken prior to embarking on clinical trials in humans.
Lund
R D
RD
Institute of Ophthalmology, Bath Street, EC1V 9EL, London, UK.
Kwan
A S
AS
Keegan
D J
DJ
Sauvé
Y
Y
Coffey
P J
PJ
Lawrence
J M
JM
D000818:Animals; D002470:Cell Survival; D017690:Cell Transplantation / Q000379:methods*; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000166:cytology*; D012160:Retina / Q000166:cytology*; D012162:Retinal Degeneration / Q000601:surgery*