Dendritic cell differentiation from hematopoietic CD34+ progenitor cells.
Dendritic cells (DC) are the most powerful antigen presenting cells (APC) and play a pivotal role in initiating the immune response. In light of their unique properties, DC have been proposed as a tool to enhance immunity against infectious agents and in anticancer vaccine strategies. In the last few years, the development of DC has been extensively investigated. The present paper summarizes the most recent findings on the differentiation of myeloid DC from hematopoietic CD34+ progenitors and methods for DC generation in vitro. A better understanding of DC function has important implications for their use in clinical settings.
Curti
A
A
L. and A. Seràgnoli, Institute of Hematology and Medical Oncology, University of Bologna, Italy.
Fogli
M
M
Ratta
M
M
Biasco
G
G
Tura
S
S
Lemoli
R M
RM
D018952:Antigens, CD34 / Q000032:analysis*; D002454:Cell Differentiation; D003713:Dendritic Cells / Q000502:physiology*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D018952:Antigens, CD34; D014409:Tumor Necrosis Factor-alpha; D016178:Granulocyte-Macrophage Colony-Stimulating Factor