Calcium Channels Formed by Mammalian Trp Homologues.
Homologues of Drosophila trp genes have been isolated from mammalian species in hope that they may constitute the molecular basis of capacitative Ca(2+) entry. Expression of Trps suggests that they form Ca(2+) influx channels regulated by either store depletion or a more upstream event. Store-operated Trp channels can be formed by heteromultimerization.
Zhu
Xi
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Dept. of Pharmacology and the Neurobiotechnology Center, Ohio State Univ., Columbus, OH 43210, USA.
Birnbaumer
Lutz
L