title: Quantitation of chondroitin-sulfates, disaccharides and hyaluronan in normal, early and advanced osteoarthritic sheep temporomandibular joints.
abstract: OBJECTIVE
  To determine the relationship between synovial fluid, chondroitin sulfate disaccharide and hyaluronic acid to differing degrees of experimental temporomandibular joint (TMJ) osteoarthritis (OA).
  
  
  METHODS
  Twenty-four merino sheep were divided into three groups and had different TMJ surgical procedures to produce OA. Group I; control (six sheep), Group II; disc perforation (nine sheep) and Group III; disc perforation and articular damage (nine sheep). Synovial fluid was collected initially and at sacrifice at 3 months. Chondroitin 4-sulfate, chondroitin 6-sulfate and hyaluronic acid were measured and correlated to the OA histologic score.
  
  
  RESULTS
  The chondroitin-sulfate levels were significantly increased (Group I to Group II P< 0.001; Group I to Group III P< 0.001), the hyaluronic acid levels decreased (Group I to Group II P< 0.01; Group I to Group III P< 0.01) with the increasing OA score.
  
  
  CONCLUSIONS
  Chondroitin-sulfate and hyaluronic acid show a correlation with surgically created TMJ osteoarthritis in sheep model.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Gifu Prefectural Gifu Hospital, Japan. ishimaru@ktroad.ne.jp
authors.forename: J I
authors.initials: JI
authors.lastname: Ishimaru
authors.forename: N
authors.initials: N
authors.lastname: Ogi
authors.forename: S
authors.initials: S
authors.lastname: Mizuno
authors.forename: A N
authors.initials: AN
authors.lastname: Goss
mesh_terms: D000818:Animals; D002809:Chondroitin Sulfates / Q000378:metabolism*; D004187:Disaccharides / Q000378:metabolism*; D006820:Hyaluronic Acid / Q000378:metabolism*; D010003:Osteoarthritis / Q000378:metabolism*; D012756:Sheep; D013582:Synovial Fluid / Q000737:chemistry*; D013704:Temporomandibular Joint
chemical_list: D004187:Disaccharides; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates