Increased proportion of HLA-class-I-specific natural killer cell receptors (CD94) on peripheral blood mononuclear cells after allogeneic bone marrow transplantation.
In the present study, we investigated the inhibitory natural killer cell receptor (NKR) expression of CD94/NKG2A on PBMC after allogeneic bone marrow transplantation (BMT). The proportion of CD94 expression on PBMC was higher in patients without chronic graft-versus-host disease (cGVHD) and also in cGVHD patients with good response to conventional immunosuppressive therapy than in cGVHD patients with poor response. Also, the proportions of CD94+/CD3+ cells and CD94+/CD8+ cells were higher in cGVHD patients showing good response. In addition, the proportion of NKG2A-expressing cells was higher in patients without cGVHD than in patients with cGVHD. Therefore, chronic allostimulation after allo-BMT may augment the proportion of CD94/NKG2A-positive cells, and these cells may play some role in the regulation of alloresponse in some patients.
Tanaka
J
J
Department of Hematology and Oncology, Hokkaido University Graduate School of Medicine, Sapporo, Japan.
Tutumi
Y
Y
Zhang
L
L
Mori
A
A
Kahata
K
K
Toyoshima
N
N
Ohta
S
S
Kobayashi
S
S
Hashino
S
S
Asaka
M
M
Imamura
M
M
D015703:Antigens, CD / Q000378:metabolism*; D016026:Bone Marrow Transplantation / Q000276:immunology; D017252:CD3 Complex; D018414:CD8-Positive T-Lymphocytes; D016022:Case-Control Studies; D006086:Graft vs Host Disease / Q000097:blood / Q000276:immunology; D019337:Hematologic Neoplasms / Q000097:blood / Q000150:complications / Q000628:therapy; D006801:Humans; D007694:Killer Cells, Natural / Q000166:cytology / Q000378:metabolism; D037181:Lectins, C-Type; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000378:metabolism*; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011971:Receptors, Immunologic / Q000378:metabolism; D055607:Receptors, Natural Killer Cell; D013601:T-Lymphocytes; D014184:Transplantation, Homologous / Q000276:immunology*; D016896:Treatment Outcome
D015703:Antigens, CD; D017252:CD3 Complex; C527054:KLRC1 protein, human; C497869:KLRD1 protein, human; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D055654:NK Cell Lectin-Like Receptor Subfamily C; D051920:NK Cell Lectin-Like Receptor Subfamily D; D011971:Receptors, Immunologic; D055607:Receptors, Natural Killer Cell