title: Effect of lung inflation on arterial spin labeling signal in MR perfusion imaging of human lung.
abstract: The effect of lung inflation on arterial spin-labeling signal in lung perfusion is investigated. Arterial spin-labeling schemes, called alternation of selective inversion pulse (ASI) and its hybrid (HASI), which uses blood water as an endogenous, freely diffusible tracer, were applied to magnetic resonance (MR) perfusion imaging of the lung. Perfusion-weighted images of the lung from nine healthy volunteers were obtained at different time delays. There was a significant signal difference in ASI images acquired at different respiratory phases. Greater signal enhancement has been observed when the volunteers performed breath holding on end expiration than on end inspiration. This is in agreement with the normal physiologic effect of lung inflation on the pressure-flow relationship of pulmonary vasculature. ASI and HASI perfusion-weighted images show similar lung features and image quality. Preliminary results from pulmonary embolism patients indicate that arterial spin labeling is sensitive for the detection of areas of perfusion deficit. J. Magn. Reson. Imaging 2001;13:954-959.
authors.affiliation: Department of Radiology, Beth Israel Deaconess Medical Center and Harvard School of Medicine, Boston, Massachusetts, USA. vmai@enh.org
authors.forename: V M
authors.initials: VM
authors.lastname: Mai
authors.forename: Q
authors.initials: Q
authors.lastname: Chen
authors.forename: A A
authors.initials: AA
authors.lastname: Bankier
authors.forename: M
authors.initials: M
authors.lastname: Blake
authors.forename: K D
authors.initials: KD
authors.lastname: Hagspiel
authors.forename: J
authors.initials: J
authors.lastname: Knight-Scott
authors.forename: S S
authors.initials: SS
authors.lastname: Berr
authors.forename: R R
authors.initials: RR
authors.lastname: Edelman
mesh_terms: D000328:Adult; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008168:Lung / Q000098:blood supply* / Q000473:pathology; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000473:pathology; D011655:Pulmonary Embolism / Q000175:diagnosis; D012123:Pulmonary Ventilation / Q000502:physiology*; D011669:Pulmonary Wedge Pressure / Q000502:physiology; D012016:Reference Values; D012039:Regional Blood Flow / Q000502:physiology