title: [Analysis on genetic polymorphism of 13 STR loci on chromosomes 11 and 19 in Chinese Hans].
abstract: OBJECTIVE
  To analyze the genetic polymorphism of 8 STR loci on chromosome 11 and 5 STR loci on chromosome 19 in Chinese Hans.
  
  
  METHODS
  Polymerase chain reaction-single strand length polymorphism(PCR-SSLP) was used to genotype 100 randomly selected individuals of the Han nationality at 8 STR loci(D11S1984, D11S1999, D11S1392, D11S1985, D11S2002, D11S1986, D11S4464 and D11S2359) on chromosome 11 and 5 STR loci(D19S247, D19S714, D19S433, D19S246, D19S254) on chromosome 19.
  
  
  RESULTS
  Eight alleles and 26 genotypes, 9 alleles and 15 genotypes, 6 alleles and 16 genotypes, 12 alleles and 40 genotypes, 6 alleles and 19 genotypes, 12 alleles and 48 genotypes, 8 alleles and 20 genotypes, 7 alleles and 13 genotypes were observed at D11S1984, D11S1999, D11S1392, D11S1985, D11S2002, D11S1986, D11S4464 and D11S2359. The heterozygosities for the 8 STR loci were 87%, 68%, 73%, 92%, 71%, 86%, 75% and 71%, respectively. Ten alleles and 19 genotypes, 10 alleles and 26 genotypes, 10 alleles and 24 genotypes, 11 alleles and 29 genotypes, 8 alleles and 18 genotypes were observed at D19S247, D19S714, D19S433, D19S246, D19S254. The heterozygosities for the 5 STR loci were 63%, 82% 72%, 81% 74%, respectively.
  
  
  CONCLUSIONS
  The distribution of allele frequencies of 8 STR loci on chromosome 11 and 5 STR loci on chromosome 19 was consistent with the Hardy-Weinberg equilibrium and the highly genetic polymorphism was observed in Chinese Han population.
authors.affiliation: Department of Medical Genetics, Shandong Medical University, Jinan, Shandong 250012 P. R. China. gongyaoqin@yahoo.com
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Gong
authors.forename: C
authors.initials: C
authors.lastname: Guo
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Zou
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: Guo
mesh_terms: D002681:China / Q000208:ethnology; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002888:Chromosomes, Human, Pair 19; D006801:Humans; D011110:Polymorphism, Genetic; D020080:Tandem Repeat Sequences