Testosterone 5alpha-reductase inhibitory active constituents from Anemarrhenae Rhizoma.
The diethyl ether extract of Anemarrhenae Rhizoma (rhizomes of Anemarrhena asphodeloides Bunge) showed testosterone 5alpha-reductase inhibitory activity. Two major constituents, cis-hinokiresinol (1) and 2,6,4'-trihydroxy-4-methoxybenzophenone (2) were identified as the active principles. The inhibitory activity of 1 was superior to that of ethinylestradiol, but that of 2 was weak.
Matsuda
H
H
Faculty of Pharmaceutical Sciences, Kinki University, Higashiosaka, Osaka, Japan. matsuda@phar.kindai.ac.jp
Sato
N
N
Yamazaki
M
M
Naruto
S
S
Kubo
M
M
D058891:5-alpha Reductase Inhibitors; D000818:Animals; D004791:Enzyme Inhibitors / Q000032:analysis*; D008297:Male; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley
D058891:5-alpha Reductase Inhibitors; D004791:Enzyme Inhibitors