title: Quantitative assessment of cerebral ventricular volumes in chronic fatigue syndrome.
abstract: Previous qualitative volumetric assessment of lateral ventricular enlargement in chronic fatigue syndrome (CFS) has provided evidence for subtle structural changes in the brains of some individuals with CFS. The aim of this pilot study was to determine whether a more sensitive quantitative assessment of the lateral ventricular system would support the previous qualitative findings. In this study, we compared the total lateral ventricular volume, as well as the right and left hemisphere subcomponents in 28 participants with CFS and 15 controls. Ventricular volumes in the CFS group were larger than in control groups, a difference that approached statistical significance. Group differences in ventricular asymmetry were not observed. The results of this study provide further evidence of subtle pathophysiological changes in the brains of participants with CFS.
authors.affiliation: Departments of Psychiatry and Radiology, University of Medicine and Dentistry of New Jersey, New Jersey Medical School, 30 Bergen Street, Newark, NJ 07107, USA. langegu@umdnj.edu
authors.forename: G
authors.initials: G
authors.lastname: Lange
authors.forename: A I
authors.initials: AI
authors.lastname: Holodny
authors.forename: J
authors.initials: J
authors.lastname: DeLuca
authors.forename: H J
authors.initials: HJ
authors.lastname: Lee
authors.forename: X H
authors.initials: XH
authors.lastname: Yan
authors.forename: J
authors.initials: J
authors.lastname: Steffener
authors.forename: B H
authors.initials: BH
authors.lastname: Natelson
mesh_terms: D000328:Adult; D000886:Anthropometry; D002552:Cerebral Ventricles / Q000033:anatomy & histology / Q000473:pathology*; D015673:Fatigue Syndrome, Chronic / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged