Methadone-induced myoclonus in advanced cancer.
Methadone is recommended as being free of some of the neuropsychological side effects noticed with morphine, which are attributed to active metabolites. A patient that received methadone for cancer-associated pain developed myoclonus as a side effect. This has rarely been reported before in the literature. The pathophysiology and management of myoclonus are discussed.
Sarhill
N
N
Harry R. Horvitz Center for Palliative Medicine, Cleveland Clinic Taussig Cancer Center, Cleveland, Ohio, USA.
Davis
M P
MP
Walsh
D
D
Nouneh
C
C
D000701:Analgesics, Opioid / Q000009:adverse effects*; D003110:Colonic Neoplasms / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008691:Methadone / Q000009:adverse effects*; D008875:Middle Aged; D009207:Myoclonus / Q000139:chemically induced* / Q000145:classification / Q000503:physiopathology / Q000628:therapy; D010146:Pain / Q000188:drug therapy* / Q000209:etiology*; D013727:Terminal Care / Q000379:methods*
D000701:Analgesics, Opioid; D008691:Methadone