Diterpenes from the bark and seeds of Colophospermum mopane.
The CHCl3 extract of the bark and seeds of Colophospermum mopane gave three new diterpenes, dihydrogrindelic acid and dihydrogrindelaldehyde and methyl labd-13E-en-15-oate. The structures were assigned on the basis of detailed spectroscopic data analyses. The aldehyde showed significant cytotoxic activity against a human breast cancer cell line.
Mebe
P P
PP
epartment of Chemistry, University of Zimbabwe, Mount Pleasant, Harare. mebe@compcentre.uz.ac.zw
D000447:Aldehydes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D001943:Breast Neoplasms / Q000188:drug therapy; D002460:Cell Line / Q000187:drug effects; D004224:Diterpenes / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D019685:Rosales / Q000145:classification*; D012639:Seeds / Q000737:chemistry; D013019:South Africa; D014197:Trees
D000447:Aldehydes; D000970:Antineoplastic Agents; D004224:Diterpenes; C438047:dihydrogrindelaldehyde