Antibodies to factor XII and recurrent fetal loss in patients with the anti-phospholipid syndrome.
Forty female patients with either primary anti-phospholipid syndrome (n = 26) or systemic lupus erythematosus (anti-phospholipid syndrome positive) (n = 14) were investigated for levels of factor XII, the presence of lupus anticoagulant and antibodies to cardiolipin, beta 2-glycoprotein I and factor XII. Twenty-one patients had a history of recurrent fetal loss (> 2, mean = 2.6). Lupus anticoagulant positivity showed a weak association with recurrent fetal loss (odds ratio = 1.1). While there was no association between the presence of antibodies to cardiolipin or beta 2-glycoprotein I with recurrent fetal loss, antibodies to factor XII showed a strong and statistically significant association (odds ratio = 5.4, P = 0.025).
Jones
D W
DW
Kent Haemophilia Centre, Kent and Canterbury Hospital, Canterbury, Kent, UK. wynne.jones@kch-tr.sthames.nhs.uk
MacKie
I J
IJ
Gallimore
M J
MJ
Winter
M
M
D000026:Abortion, Habitual / Q000150:complications / Q000276:immunology*; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications / Q000276:immunology*; D001157:Arterial Occlusive Diseases / Q000276:immunology; D001323:Autoantibodies / Q000097:blood*; D016001:Confidence Intervals; D005174:Factor XII / Q000276:immunology*; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D016017:Odds Ratio; D011247:Pregnancy; D013927:Thrombosis / Q000276:immunology; D020246:Venous Thrombosis / Q000276:immunology; D053482:beta 2-Glycoprotein I
D017153:Antibodies, Anticardiolipin; D001323:Autoantibodies; D006023:Glycoproteins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D016682:Lupus Coagulation Inhibitor; D053482:beta 2-Glycoprotein I; D005174:Factor XII