Measurement of allergenic potency using the local lymph node assay.
Chemicals that can act as contact allergens have been identified successfully using guinea-pig models. However, contact allergy is still common, probably because of, at least in part, failures of risk assessment. A new method, the local lymph node assay, replaces the guinea-pig as a tool for hazard identification and offers the real prospect of accurate prediction of allergen potency, the missing link in skin sensitization risk assessment.
Basketter
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DA
SEAC Toxicology Unit, Unilever Research, Colworth House, Sharnbrook, Bedford, UK MK441LQ. David.Basketter@unilever.com
Gerberick
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GF
Kimber
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I
D000485:Allergens / Q000276:immunology; D000818:Animals; D006168:Guinea Pigs; D023441:Local Lymph Node Assay; D051379:Mice; D008808:Mice, Inbred CBA
D000485:Allergens