[Association analysis of attempted suicide and 5-HT2A receptor gene].
OBJECTIVE
To examine the relationship of attempted suicide with A-1438G and T102C polymorphisms of 5-HT2A receptor gene.


METHODS
Genotypes and allele frequencies of A-1438G and T102C polymorphisms of 5-HT2A receptor gene in 149 attempted suicides and 190 normal controls were examined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP).


RESULTS
No differences in genotypes and allele frequencies of A-1438G and T102C polymorphisms of 5-HT2A receptor gene were observed between attempted suicides and the controls. However, an association between male attempted suicides and genotype(GG) of A-1438G polymorphism was found.


CONCLUSIONS
These results suggested that liability to suicide behavior might be associated with A-1438G polymorpyhism of 5-HT2A receptor gene in male subjects.
Cao
L
L
Department of Psychiatry, the First Affiliated Hospital, West China University of Medical Sciences, Chengdu, Sichuan 610041 P. R. China. caoliping@hotmail.com
Li
T
T
Xu
K
K
Liu
X
X
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D013406:Suicide, Attempted
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin