title: Toward Understanding the Role of Methylation in Aldosterone-Sensitive Na(+) Transport.
abstract: Proper endocrine regulation of Na(+) reabsorption by renal principal cells is the primary means in mammals for maintaining blood pressure. Aldosterone increases Na(+) reabsorption by activating luminal Na(+) channels; however, the signal transduction pathway of aldosterone is not fully understood. Cellular methylation is necessary for aldosterone signaling to the luminal Na(+) channel. We describe the enzymes, regulators, and effectors of aldosterone-mediated methylation relevant to Na(+) reabsorption.
authors.affiliation: D. Stockand is in the Department of Physiology, University of Texas Health Science Center San Antonio, San Antonio, Texas 78284-7756.
authors.forename: James D.
authors.initials: JD
authors.lastname: Stockand
authors.forename: Robert S.
authors.initials: RS
authors.lastname: Edinger
authors.forename: Douglas C.
authors.initials: DC
authors.lastname: Eaton
authors.forename: John P.
authors.initials: JP
authors.lastname: Johnson