title: P-450 Eicosanoids: A Novel Signaling Pathway Regulating Renal Function.
abstract: Cytochrome P-450 enzymes primarily metabolize arachidonic acid to epoxyeicosatrienoic acids (EETs) and 20-hydroxyeicosatetraenoic acid (20-HETE) in the kidney. These compounds serve as second messengers that play a central role in the regulation of renal vascular tone and sodium reabsorption in the proximal tubule and thick ascending loop of Henle.
authors.affiliation: Department of Physiology, Medical College of Wisconsin, Milwaukee, WI 53226.
authors.forename: Richard J.
authors.initials: RJ
authors.lastname: Roman
authors.forename: Magdalena
authors.initials: M
authors.lastname: Alonso-Galicia