Preparation of 1,4-oxaselenin from agNO(3)/LDA-assisted reaction of 3-selena-4-pentyn-1-one as potential antitumor agents.
1,4-Oxaselenins were synthesized from 3-selena-4-pentyn-1-ones by the use of AgNO(3) and LDA. One of the obtained oxaselenins, 2-(4-chlorophenyl)-6-phenyl-1,4-oxaselenin 5c, showed an inhibitory effect against the proliferation of human cancer cells and inducing effects on the early stage of apoptosis.
Koketsu
M
M
Department of Chemistry, Faculty of Engineering, Gifu University, Gifu, 501-1193 Japan. koketsu@cc.gifu-u.ac.jp
Yang
H O
HO
Kim
Y M
YM
Ichihashi
M
M
Ishihara
H
H
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D018036:Selenium Compounds / Q000737:chemistry*; D012835:Silver Nitrate
C431045:1,4-oxaselenin; C431044:3-selena-4-pentyn-1-one; D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D018036:Selenium Compounds; D012835:Silver Nitrate