title: Hepatic biotransformation profiles of sulphamonomethoxine in food-producing animals and rats in vitro.
abstract: Hydroxylation and acetylation of sulphamonomethoxine (SMM) and deacetylation of N4-acetyl SMM (N4-AcSMM) were estimated in liver post-mitochondrial supernatants (S-9) from laying hens, female cattle, swine and rats. The formation of hydroxylated SMM, 2,6-dihydroxy SMM (2,6-diOH-SMM), was found only with hen S-9s. N4-acetylation rate of SMM was the highest in pig S-9s, followed by rat, then hen or cow S-9s. All S-9s from the four species deacetylated N4-AcSMM. In hen S-9s, the rate of 2,6-dihydroxylation was higher during incubation at 41 degrees C than at 37 degrees C.
authors.affiliation: Faculty of Human Life Science, Osaka City University, Osaka 558-8585, Japan. furusawa@life.osaka-cu.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Furusawa
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism / Q000493:pharmacokinetics*; D001711:Biotransformation; D002645:Chickens; D004285:Dogs; D005260:Female; D006900:Hydroxylation; D008099:Liver / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013422:Sulfamonomethoxine / Q000378:metabolism / Q000493:pharmacokinetics*; D013552:Swine
chemical_list: D000890:Anti-Infective Agents; D013422:Sulfamonomethoxine