A configurationally stable alkoxy allenyl zinc reagent, en route to anti-anti vicinal amino diols.
[see reaction]. The reaction of an alkoxyallenyl zinc reagent with benzyl imines derived from lactic and mandelic acids proceeds highly diastereoselectively and leads to 2-amino-1,3-diol derivatives with an anti-anti pattern.
Poisson
J F
JF
Laboratoire de Chimie des Organoéléments, Université Pierre et Marie Curie, 4 place Jussieu 75252 Paris cédex 05, France.
Normant
J F
JF