Arsenite-induced multiple antibiotic resistance phenotype in environmental isolates of Yersinia enterocolitica.
Minimal inhibitory concentrations (MICs) of five antibiotics namely amikacin, gentamicin, tetracycline, ciprofloxacin, and nitrofurantoin for pork isolates of Yersinia enterocolitica increased two- to eightfold after bacteria were grown in the presence of 5 mm arsenite. For Y. enterocolitica isolates obtained from wastewater (sewage effluents), an unequivocal increase in MICs was seen with amikacin and gentamicin. No change was discernible in the outer-membrane proteins after isolates were grown in the presence of arsenite.
Virdi
J S
JS
Microbial Pathogenicity Laboratory, Department of Microbiology, University of Delhi South Campus, Benito Juarez Road, New Delhi-110021, India. micro@dusc.ernet.in
Sinha
I
I
Rajendran
P
P
Singh
I
I
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D018053:Arsenites / Q000494:pharmacology*; D001425:Bacterial Outer Membrane Proteins / Q000032:analysis; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D008460:Meat / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D012722:Sewage / Q000382:microbiology; D013552:Swine; D015008:Yersinia enterocolitica / Q000737:chemistry / Q000187:drug effects* / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D018053:Arsenites; D001425:Bacterial Outer Membrane Proteins; D012722:Sewage; C015001:arsenite