Induction of oxidative stress in antitubercular drug-induced hepatotoxicity.
OBJECTIVE
Oxidative stress could play a role in the pathogenesis of antitubercular drug (ATD)-induced hepatotoxicity. We therefore studied the plasma level of reduced glutathione (GSH) and malondialdehyde (MDA) in patients with ATD-induced hepatotoxicity (cases), ATD-treated controls (disease controls) and in healthy volunteers.


METHODS
This study was carried out in a case-control design. Twenty-one cases, 21 age- and sex-matched disease controls, and 10 healthy volunteers were enrolled. Plasma levels of GSH and MDA were measured.


RESULTS
Plasma levels of GSH (median [range] 11.5 [6.2-21.2] mmol/dL) and MDA (1390 [560-2310] nmol/dL) of cases were significantly different (p<0.01) from GSH (18.4 [10.5-24.4]) and MDA (290 [240-550]) of disease controls. Further, plasma GSH and MDA levels of both the ATD-treated groups were different from those in healthy controls.


CONCLUSIONS
Lower levels of plasma GSH and higher levels of MDA may be due to oxidative stress resulting from ATD therapy.
Chowdhury
A
A
Department of Gastroenterology, Institute of Post Graduate Medical Education and Research, Kolkata. achowdhury@apexmail.com
Santra
A
A
Kundu
S
S
Mukherjee
A
A
Pandit
A
A
Chaudhuri
S
S
Dhali
G K
GK
D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000009:adverse effects*; D016022:Case-Control Studies; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology*; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D016014:Linear Models; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000097:blood*; D008875:Middle Aged; D018384:Oxidative Stress; D011446:Prospective Studies; D018709:Statistics, Nonparametric; D014376:Tuberculosis / Q000188:drug therapy
D000995:Antitubercular Agents; D008315:Malondialdehyde; D005978:Glutathione