title: Alcohol actions on GABA(A) receptors: from protein structure to mouse behavior.
abstract: This article represents the proceedings of a symposium at the 2000 ISBRA Meeting in Yokohama, Japan. The chairs were R. Adron Harris and Susumu Ueno. The presentations were (1) Protein kinase Cepsilon-regulated sensitivity of gamma-aminobutyric acid type A (GABAA) receptors to allosteric agonists, by Robert O. Messing, A. M. Sanchez-Perez, C. W. Hodge, T. McMahon, D. Wang, K. K. Mehmert, S. P. Kelley, A. Haywood, and M. F. Olive; (2) Genetic and functional analysis of a GABAA receptor gamma2 subunit variant: A candidate for quantitative trait loci involved in alcohol sensitivity and withdrawal, by Kari J. Buck and Heather M. Hood; (3) Tryptophan-scanning mutagenesis in GABAA receptor subunits: Channel gating and alcohol actions, by Susumu Ueno; and (4) Can a single binding site account for actions of alcohols on GABAA and glycine receptors? by R. Adron Harris, Yuri Blednov, Geoffrey Findlay, and Maria Paola Mascia.
authors.affiliation: Waggoner Center for Alcohol and Addiction Research, University of Texas at Austin, Austin, Texas 78712, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ueno
authors.forename: R A
authors.initials: RA
authors.lastname: Harris
authors.forename: R O
authors.initials: RO
authors.lastname: Messing
authors.forename: A M
authors.initials: AM
authors.lastname: Sanchez-Perez
authors.forename: C W
authors.initials: CW
authors.lastname: Hodge
authors.forename: T
authors.initials: T
authors.lastname: McMahon
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: K K
authors.initials: KK
authors.lastname: Mehmert
authors.forename: S P
authors.initials: SP
authors.lastname: Kelley
authors.forename: A
authors.initials: A
authors.lastname: Haywood
authors.forename: M F
authors.initials: MF
authors.lastname: Olive
authors.forename: K J
authors.initials: KJ
authors.lastname: Buck
authors.forename: H M
authors.initials: HM
authors.lastname: Hood
authors.forename: Y
authors.initials: Y
authors.lastname: Blednov
authors.forename: G
authors.initials: G
authors.lastname: Findlay
authors.forename: M P
authors.initials: MP
authors.lastname: Mascia
mesh_terms: D000595:Amino Acid Sequence / Q000187:drug effects / Q000235:genetics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D001665:Binding Sites / Q000187:drug effects / Q000235:genetics; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D000431:Ethanol / Q000494:pharmacology*; D018755:GABA Agonists / Q000494:pharmacology; D006801:Humans; D007527:Isoenzymes / Q000187:drug effects / Q000235:genetics; D051379:Mice; D009154:Mutation / Q000187:drug effects* / Q000235:genetics; D011493:Protein Kinase C / Q000187:drug effects / Q000235:genetics; D051744:Protein Kinase C-epsilon; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000235:genetics; D018009:Receptors, Glycine / Q000187:drug effects / Q000235:genetics
chemical_list: D002492:Central Nervous System Depressants; D018755:GABA Agonists; D007527:Isoenzymes; D011963:Receptors, GABA-A; D018009:Receptors, Glycine; D000431:Ethanol; C497256:Prkce protein, mouse; C497255:PRKCE protein, human; D011493:Protein Kinase C; D051744:Protein Kinase C-epsilon