Hydroxyurea for sickle cell disease.
BACKGROUND
Sickle cell disease is one of the most common inherited diseases world wide. It is associated with life long morbidity and a reduced life expectancy. Hydroxyurea, a chemotherapeutic drug taken by mouth, raises fetal haemoglobin and, as such, is expected to ameliorate some of the clinical problems of sickle cell disease.


OBJECTIVE
To assess the effects of hydroxyurea therapy in sickle cell disease patients of all types, of any age, regardless of setting.


METHODS
We searched the Cochrane Cystic Fibrosis and Genetic Disorders Group specialised register of controlled trials for haemoglobinopathies, which comprises references identified from comprehensive electronic database searches, hand-searching relevant journals, and hand-searching abstract books of conference proceedings. Date of the most recent search(es): November 2000.


METHODS
All randomised or quasi-randomised controlled trials comparing the use of oral hydroxyurea for one month or longer with placebo, standard therapy or other interventions for the treatment of patients with sickle cell disease.


METHODS
Both reviewers independently assessed trial quality and extracted data from the two studies included.


RESULTS
Twenty trials were found of which two trials, which reported results from a total of 324 adults and children were suitable for inclusion in the review. From the data provided in the published reports only one study (the MSH study to the United States of America) could be analysed. This study showed marked differences in favour of hydroxyurea treatment as compared with placebo in terms of annual crisis rate, use of transfusions, and life-threatening complications (in particular, the acute sickle chest syndrome). No serious adverse effects were reported from either study.


CONCLUSIONS
While hydroxyurea appears both effective and safe in the severely affected SS adults over a two year period; further studies are required to elucidate its role in other patient groups and for other conditions.
Davies
S
S
NHS Executive, Department of Health, 40 Eastbourne Terrace, London, UK, W2 3QR. sdaviet@doh.gov.uk
Olujohungbe
A
A
D000986:Antisickling Agents / Q000627:therapeutic use*; D006450:Hemoglobin SC Disease / Q000188:drug therapy*; D006801:Humans; D006918:Hydroxyurea / Q000627:therapeutic use*; D016032:Randomized Controlled Trials as Topic
D000986:Antisickling Agents; D006918:Hydroxyurea