Cardioprotective effects of Picrorrhiza kurroa against isoproterenol-induced myocardial stress in rats.
The cardioprotective effect of the ethanol extract of Picrorrhiza kurroa rhizomes and roots (PK) on isoproterenol-induced myocardial infarction in rats with respect to lipid metabolism in serum and heart tissue has been investigated. Oral pre-treatment with PK (80 mg kg(-1) day(-1) for 15 days) significantly prevented the isoproterenol-induced myocardial infarction and maintained the rats at near normal status.
Senthil Kumar
S H
SH
Bharathidasan College of Arts and Science, Ellispettai, Pallapalayam (PO), 638-116, Erode, India.
Anandan
R
R
Devaki
T
T
Santhosh Kumar
M
M
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood / Q000187:drug effects; D008078:Cholesterol, LDL / Q000097:blood / Q000187:drug effects; D007545:Isoproterenol; D008054:Lipid Peroxides / Q000097:blood; D019684:Magnoliopsida; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism*; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018517:Plant Roots; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D014280:Triglycerides / Q000097:blood
D002316:Cardiotonic Agents; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008054:Lipid Peroxides; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol; D007545:Isoproterenol