Characterisation and disintegration properties of irradiated starch.
Irradiation treatment could provide a quick and simple way to modify the physical, chemical and pharmaceutical properties of biopolymers such as starch. Corn, potato and drum dried corn starch were exposed to X-ray and electron beam (e-beam) irradiation treatment at doses of 10, 50 and 100 kGy. The disintegration properties of these starches were compared using alpha-lactose monohydrate tablets containing 5% (w/w) starch as disintegrant. Starch solubility increased, while its swelling capacity decreased with increasing irradiation dose. The irradiation treatment caused fragmentation of the amylopectin fraction. Irradiation modified the different starches thoroughly, showing remarkable differences in disintegration properties after X-ray treatment and e-beam modification. The e-beam modification resulted in significantly higher disintegration times of the tablets.
De Kerf
M
M
Laboratory of Pharmaceutical Technology, Ghent University, Harelbekestraat 72, 9000 Gent, Belgium.
Mondelaers
W
W
Lahorte
P
P
Vervaet
C
C
Remon
J P
JP
D008970:Molecular Weight; D012995:Solubility; D013213:Starch / Q000528:radiation effects*; D013607:Tablets; D013678:Technology, Pharmaceutical
D013607:Tablets; D013213:Starch