title: Cytodiagnosis of a meningeal fibrosarcoma metastatic to the thyroid gland.
abstract: A case of primary leptomeningeal fibrosarcoma metastatic to the thyroid gland, diagnosed by fine needle aspiration biopsy is described. The patient, a 39-year-old women was initially diagnosed with a leptomeningeal fibrosarcoma. Sections of the primary tumor studied by electron microscopy showed that the tumor cells have the ultrastructure features of a fibroblast. She underwent tumor resection, followed by chemotherapy and local radiotherapy. Four months later, she presented with dysphagia. Ultrasonography confirmed the presence of a 2-cm mass in the right lobe of thyroid. A fine needle aspiration biopsy was performed. Light microscopy showed interwoven bundles of neoplastic spindle cells similar to the primary tumor, consistent with a metastatic fibrosarcoma. To our knowledge, this is the first report of a primary meningeal fibrosarcoma that metastasized to the thyroid gland, which was diagnosed by a fine needle aspiration biopsy.
authors.affiliation: Department of Pathology, William Beaumont Hospital, Royal Oak, MI, USA.
authors.forename: W A
authors.initials: WA
authors.lastname: Khan
authors.forename: H
authors.initials: H
authors.lastname: Attal
authors.forename: J
authors.initials: J
authors.lastname: Vernick
authors.forename: C W
authors.initials: CW
authors.lastname: Bedrossian
mesh_terms: D000328:Adult; D001707:Biopsy, Needle / Q000379:methods*; D003582:Cytogenetics; D003937:Diagnosis, Differential; D005260:Female; D005354:Fibrosarcoma / Q000175:diagnosis* / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007150:Immunohistochemistry; D007621:Karyotyping; D008577:Meningeal Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011003:Ploidies; D013964:Thyroid Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D014463:Ultrasonography