title: Long-term follow-up of cartilaginous tumors of the larynx.
abstract: BACKGROUND
  Cartilaginous tumors of the larynx are uncommon. A literature review disclosed approximately 250 cases since 1816; the cricoid cartilage is the most common site. The rarity of these tumors has made for limited experience and, as a consequence, our knowledge is incomplete.
  
  
  OBJECTIVE
  To report surgical results as well as long-term follow-up on 6 patients with cartilaginous tumors of the larynx.
  
  
  METHODS
  A 28-year retrospective study with the patients followed-up from 6 to 28 years (average, 17.8 years).
  
  
  METHODS
  Six adult white male patients with cartilaginous tumors of the larynx: 4 low-grade chondrosarcoma (1 of the thyroid and 3 of the cricoid) and 2 chondroma of the cricoid. Surgical treatment included total laryngectomy of the thyroid and 1 of the cricoid chondrosarcoma, and conservation surgery of the other 4 cricoid tumors: the 2 patients with chondrosarcoma had total resection of the cricoid cartilage with thyrotracheal anastomosis, and the 2 patients with chondroma had local tumor resection using a laryngofissure approach.
  
  
  RESULTS
  The margins of the specimen were negative for tumor in the 6 patients. On follow-up, none of the patients had regional or distant metastasis or tumor-related death. One of the patients with cricoid chondrosarcoma developed recurrence 8 years after conservation surgery, and required a total laryngectomy for salvage. Survival rate tumor-free at 5 years was 100% and at 10 years 67%, co-morbidity being responsible for the decrease in survival rate.
  
  
  CONCLUSIONS
  Based on this small series of patients, the long-term follow-up of benign and low-grade malignant tumors suggests that the surgical approach and prognosis does not depend on histologic distinction and, importantly, underdiagnosed malignancy on tumor sampling and recurrent chondrosarcoma, managed with salvage surgery, have no adverse impact on patient survival. Total resection of the cricoid cartilage with thyrotracheal anastomosis over a stent proved an alternative surgical technique in chondrosarcoma who otherwise would have been treated by total laryngectomy.
authors.affiliation: Private Clinic of Head and Neck Surgery, 483 Alameda Itú, São Paulo, SP-Brazil 01421-000.
authors.forename: R
authors.initials: R
authors.lastname: Thomé
authors.forename: D C
authors.initials: DC
authors.lastname: Thomé
authors.forename: R A
authors.initials: RA
authors.lastname: de la Cortina
mesh_terms: D000328:Adult; D002812:Chondroma / Q000601:surgery*; D002813:Chondrosarcoma / Q000601:surgery*; D003413:Cricoid Cartilage / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007822:Laryngeal Neoplasms / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D015607:Stents; D016896:Treatment Outcome