title: [Single-strand DNA breaks in brain cells of different rat strains under normal condition and during exposure to stress].
abstract: This study was aimed to characterize pattern of occurrence of spontaneous single-strand breaks in situ in glial and neuronal nuclei of the cortex, middle brain and hyppocapmi (CA3 field) of rats selected for a threshold of nervous system excitability, and to study the influence of stress of various modality on such breaks. The results obtained evidence that: 1) intact animals possess a subpopulation of glial and neuronal cells revealed following gap filling in situ in opposite to other types of terminally differentiated non-proliferating cells; 2) the size of such a subpopulation differs depending on the lines of examined rats, parts of brain, and the type of stress.
authors.affiliation: Institute of Experimental Medicine RAMS, St. Petersburg, and Physiological Institute RAS, St. Petersburg.
authors.forename: E L
authors.initials: EL
authors.lastname: Patkin
authors.forename: A I
authors.initials: AI
authors.lastname: Vaĭdo
authors.forename: M E
authors.initials: ME
authors.lastname: Kustova
authors.forename: N V
authors.initials: NV
authors.lastname: Shiriaeva
authors.forename: N G
authors.initials: NG
authors.lastname: Lopatina
mesh_terms: D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000648:ultrastructure*; D008297:Male; D009474:Neurons / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013315:Stress, Psychological / Q000235:genetics*
chemical_list: D004277:DNA, Single-Stranded