Anodic oxidation of ifosfamide and cyclophosphamide: a biomimetic metabolism model of the oxazaphosphorinane anticancer drugs.
The electrochemical oxidation of anticancer drugs ifosfamide and cyclophosphamide produced in high yield methoxylated analogues of the key hydroxy-metabolites of these oxazaphosphorine prodrugs. The cytotoxicity of these compounds was evaluated, and found to be as high as the hydroxy-metabolite.
Paci
A
A
Laboratoire de Chimie Thérapeutique, associé au CNRS et à l'Université René Descartes UMR 8638, Faculté de Pharmacie, Paris, France.
Martens
T
T
Royer
J
J
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D003520:Cyclophosphamide / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D004563:Electrochemistry / Q000379:methods; D004566:Electrodes; D006801:Humans; D007069:Ifosfamide / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D010084:Oxidation-Reduction; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D007069:Ifosfamide