title: Combined treatment of HCV infection: is there a need for meta-analysis?
abstract: Background/Aims. The aim of this study was to estabilish the 'true' therapeutical gain of a combined therapy interferon - ribavirin versus interferon monotherapy in hepatitis C virus infection.Methods. A systematic review of published trials comparing combined treatment (interferon+ribavirin) vs interferon monotherapy, was performed on articles printed from 1991 to 1999.Results. The meta-analysis of retrieved trials showed that ribavirin significantly enhances the sustained response rate to interferon therapy in all types of patients. The results of almost all studies were homogeneous: combined therapy approximately doubles response rates compared to interferon monotherapy. At the end of the treatment, ribavirin increased the rate of viral clearance approximately 22% and the biochemical response of about 31%. The net gain was about 24% for both viral and biochemical response rate after 24 weeks of follow-up.Conclusion. Combined therapy showed a significantly higher efficacy in terms of sustained negativity of viral genome in all classes of patients (naives, relapsers, non-responders) becoming the therapy of choice. Nevertheless, more than about 50% of patients infected by hepatitis C virus show no sustained response to treatment. The whole weight of final data is beared by the major trials all with similar results.
authors.affiliation: Gastroenterology Unit, Department of Clinical Sciences, Policlinico 'La Sapienza' University, Rome, Italy
authors.forename: M
authors.initials: M
authors.lastname: Bacosi
authors.forename: M
authors.initials: M
authors.lastname: Patsouri
authors.forename: L
authors.initials: L
authors.lastname: Miglioresi
authors.forename: F
authors.initials: F
authors.lastname: Patrizi
authors.forename: F
authors.initials: F
authors.lastname: Russo
authors.forename: G L.
authors.initials: GL
authors.lastname: Ricci