title: [Cell activation in the hypothalamus after exposure to an antigen (based on c-fos gene expression)].
abstract: Increase of the c-fos mRNA positive cells number was insignificant in 30 min. following activation of the rat hypothalamic structures with the tetanus toxoid (TT). Elevation of the c-fos mRNA positive cells number occurred in the hypothalamic' posterior (PHA), lateral (LHA), anterior (AHA), areas dorsomedial (DMH), and ventromedial (VMH) nuclei within 2 hours of the TT administration. In 6 hours the c-fos mRNA positive cells number decreased in PHA, LHA, DMH. The c-fos mRNA expression was stable in arquate and supraoptic hypothalamic nuclei following either the TT or saline administration.
authors.affiliation: Institute of Experimental Medicine, Russian Acad. Med. Sci, 197376, St. Petersburg, Acad. I. P. Pavlov St., 12.
authors.forename: M A
authors.initials: MA
authors.lastname: Nosov
authors.forename: S V
authors.initials: SV
authors.lastname: Barabanova
authors.forename: M S
authors.initials: MS
authors.lastname: Glushikhina
authors.forename: T B
authors.initials: TB
authors.lastname: Kazakova
authors.forename: E A
authors.initials: EA
authors.lastname: Korneva
mesh_terms: D000818:Animals; D007031:Hypothalamus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D017403:In Situ Hybridization; D008297:Male; D015213:Neuroimmunomodulation; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013745:Tetanus Toxoid / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D013745:Tetanus Toxoid