Hyphae and yeasts of Candida albicans differentially regulate interleukin-12 production by human blood monocytes: inhibitory role of C. albicans germination.
The role of Candida albicans yeast-to-hyphae transition in interleukin-12 (IL-12) production by monocytes was investigated. Germinating C. albicans not only failed to induce IL-12 p70 but also suppressed IL-12 production induced by heat-killed C. albicans. Comparison of the abilities of germinating C. albicans and agerminating mutants to inhibit IL-12 production showed that germination of C. albicans plays a critical role in the inhibition of IL-12 production.
Liu
L
L
The Center for Medical Mycology, Case Western Reserve University, Cleveland, Ohio.
Kang
K
K
Takahara
M
M
Cooper
K D
KD
Ghannoum
M A
MA
D002176:Candida albicans / Q000276:immunology* / Q000302:isolation & purification / Q000502:physiology; D002478:Cells, Cultured; D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis* / Q000235:genetics; D009000:Monocytes / Q000276:immunology* / Q000382:microbiology
D018664:Interleukin-12