title: [Gastroesophageal reflux disease and chest pain].
abstract: Gastroesophageal reflux disease (GERD) is highly prevalent in the general population. Heartburn and acid regurgitation are considered the  typical  presentation of GERD, that however might represent a major pathogenic mechanism in patients with chest pain without coronary artery disease. Chest pain in this instance is often successfully treated with high-dose antisecretory drugs, but the pathogenetic mechanism remains unclear. Further research is needed to clarify the role of GERD on the pathogenesis of chest pain and to ascertain whether a medical or surgical anti-secretory treatment could represent a possible approach. Patients with non-cardiac chest pain of unknown origin should be carefully screened for the occurrence of GERD.
authors.affiliation: Azienda Ospedaliera, S. Giovanni Battista, Molinette, Turin, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Pellicano
authors.forename: E
authors.initials: E
authors.lastname: Oliaro
authors.forename: M
authors.initials: M
authors.lastname: Berrutti
authors.forename: A
authors.initials: A
authors.lastname: Ponzetto
authors.forename: M
authors.initials: M
authors.lastname: Rizzetto
mesh_terms: D001471:Barrett Esophagus / Q000175:diagnosis; D002637:Chest Pain / Q000175:diagnosis / Q000209:etiology*; D003937:Diagnosis, Differential; D004941:Esophagitis / Q000175:diagnosis; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D006635:Histamine H2 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D054328:Proton Pump Inhibitors; D013997:Time Factors
chemical_list: D006635:Histamine H2 Antagonists; D054328:Proton Pump Inhibitors