Delay of natural bone loss by higher intakes of specific minerals and vitamins.
For early prevention or inhibition of postmenopausal and age-related bone loss, nutritional interventions might be a first choice. For some vitamins and minerals an important role in bone metabolism is known or suggested. Calcium and vitamin D support bone mineral density and are basic components in most preventive strategies. Magnesium is involved in a number of activities supporting bone strength, preservation, and remodeling. Fluorine and strontium have bone-forming effects. However, high amounts of both elements may reduce bone strength. Boron is especially effective in case of vitamin D, magnesium, and potassium deficiency. Vitamin K is essential for the activation of osteocalcin. Vitamin C is an important stimulus for osteoblast-derived proteins. Increasing the recommended amounts (US RDA 1989), adequate intakes (US DRI 1997), or assumed normal intakes of mentioned food components may lead to a considerable reduction or even prevention of bone loss, especially in late postmenopausal women and the elderly.
Schaafsma
A
A
Friesland Coberco Dairy Foods, Dep. of Research & Development Leeuwarden, The Netherlands. a.schaafsma@fdf.nl
de Vries
P J
PJ
Saris
W H
WH
D001205:Ascorbic Acid / Q000627:therapeutic use; D015519:Bone Density / Q000187:drug effects*; D001895:Boron / Q000627:therapeutic use; D002118:Calcium / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008274:Magnesium / Q000627:therapeutic use; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D010024:Osteoporosis / Q000178:diet therapy* / Q000517:prevention & control*; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control; D013324:Strontium / Q000627:therapeutic use; D014807:Vitamin D / Q000627:therapeutic use; D014812:Vitamin K / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use*
D008903:Minerals; D014815:Vitamins; D014812:Vitamin K; D014807:Vitamin D; D008274:Magnesium; D001895:Boron; D001205:Ascorbic Acid; D002118:Calcium; D013324:Strontium