title: Plasmodium falciparum and hepatitis E virus co-infection in fulminant hepatic failure.
abstract: Acute hepatitis E and falciparum malaria can each present with fulminant hepatic failure and are common in tropical countries. However, co-existence of these two conditions has not been reported. We report a 20-year-old girl who presented with fever and altered sensorium. Peripheral smear was positive for Plasmodium falciparum, and IgM anti-HEV was positive. She died despite antimalarial drugs and supportive management. Postmortem liver tissue showed changes suggestive of acute viral hepatitis.
authors.affiliation: Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow. ghoshal@sgpgi.ac.in
authors.forename: U C
authors.initials: UC
authors.lastname: Ghoshal
authors.forename: S
authors.initials: S
authors.lastname: Somani
authors.forename: K
authors.initials: K
authors.lastname: Chetri
authors.forename: P
authors.initials: P
authors.lastname: Akhtar
authors.forename: R
authors.initials: R
authors.lastname: Aggarwal
authors.forename: S R
authors.initials: SR
authors.lastname: Naik
mesh_terms: D000208:Acute Disease; D000328:Adult; D000818:Animals; D017809:Fatal Outcome; D005260:Female; D016751:Hepatitis E / Q000150:complications*; D016752:Hepatitis E virus / Q000276:immunology; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood; D017093:Liver Failure / Q000469:parasitology* / Q000821:virology*; D016778:Malaria, Falciparum / Q000150:complications*; D010963:Plasmodium falciparum / Q000302:isolation & purification
chemical_list: D007075:Immunoglobulin M