title: Treatment outcomes in acute exacerbations of chronic bronchitis: comparison of macrolides and moxifloxacin from the patient perspective.
abstract: Moxifloxacin, a new respiratory quinolone, was compared with the macrolides azithromycin, clarithromycin and roxithromycin in a cohort study to assess clinical, safety and health-related outcomes of these antimicrobials in general practice settings. In total 332 patients with acute exacerbations of chronic bronchitis (AECB) each received one of the antimicrobial agents for a standard short course of therapy. Random allocation of therapeutic agents occurred by centre, not individuals, and the drugs were prescribed in an open manner. In addition to clinical evaluation by their physicians, all patients kept daily diaries to assess AECB symptoms over the study period, therapy received and quality of life. The overall clinical response rate was 96% and all four regimens were well tolerated. After 14 days there were no significant differences between the study groups, but analyses of patients' daily evaluations of certain AECB specific symptoms showed a faster response rate in the moxifloxacin group.
authors.affiliation: Department of Internal Medicine II, Lüdenscheid District Hospital, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Lorenz
authors.forename: I M
authors.initials: IM
authors.lastname: Thate-Waschke
authors.forename: O
authors.initials: O
authors.lastname: Mast
authors.forename: R
authors.initials: R
authors.lastname: Kubin
authors.forename: R
authors.initials: R
authors.lastname: Rychlik
authors.forename: T
authors.initials: T
authors.lastname: Pfeil
authors.forename: D
authors.initials: D
authors.lastname: Daniel
authors.forename: G S
authors.initials: GS
authors.lastname: Tillotson
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001372:Aza Compounds; D017963:Azithromycin / Q000627:therapeutic use; D001991:Bronchitis / Q000188:drug therapy*; D002908:Chronic Disease; D017291:Clarithromycin / Q000627:therapeutic use; D015331:Cohort Studies; D005260:Female; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D008875:Middle Aged; D000077266:Moxifloxacin; D011804:Quinolines; D015575:Roxithromycin / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D001372:Aza Compounds; D024841:Fluoroquinolones; D011804:Quinolines; D015575:Roxithromycin; D017963:Azithromycin; D017291:Clarithromycin; D000077266:Moxifloxacin