title: Homologous recombination: from model organisms to human disease.
abstract: Recent experiments show that properly controlled recombination between homologous DNA molecules is essential for the maintenance of genome stability and for the prevention of tumorigenesis.
authors.affiliation: Department of Cell Biology and Genetics, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Modesti
authors.forename: R
authors.initials: R
authors.lastname: Kanaar
mesh_terms: D000818:Animals; D019313:BRCA1 Protein / Q000502:physiology; D024682:BRCA2 Protein; D004249:DNA Damage; D004265:DNA Helicases / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D008957:Models, Genetic; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000235:genetics; D051135:Rad51 Recombinase; D011995:Recombination, Genetic; D014157:Transcription Factors / Q000502:physiology
chemical_list: D019313:BRCA1 Protein; D024682:BRCA2 Protein; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D014157:Transcription Factors; C495153:RAD51 protein, human; D051135:Rad51 Recombinase; D004265:DNA Helicases