[Dynamic of DNAse activity induction in serum of normal animals after heterogeneous DNA injection and in hereditary pathology].
Studies of reactions in animals with hereditary diseases (Sapphire minks highly sensitive to Aleutian disease virus, ADV; CBA mice with 60-70% incidence of tumors; AKR mice with 90% incidence of leukemia) showed that serum DNAse activity in these animals dropped after injection of a foreign heterogeneous DNA and remained decreased during 72 h. By contrast, serum DNAse activity considerably and persistently increased after injection of DNA in Standard minks resistant to ADV, C57BI/6J mice with 1% tumor incidence, and random-bred albino mice. Presumably the capacity of standard minks to react to a foreign heterogeneous DNA by increase of DNAse activity ensures their resistance to DNA-containing ADV, while incapacity of Sapphire minks to respond to DNA by DNAse activity induction makes them sensitive to ADV. A similar relationship between the capacity to react to DNA by changes in serum DNAse activity and capacity to inherit a disease was detected in mouse strains.
Kovalenko
G A
GA
Gal'vita
A V
AV
D000453:Aleutian Mink Disease / Q000097:blood* / Q000276:immunology; D000818:Animals; D015415:Biomarkers; D004247:DNA / Q000008:administration & dosage / Q000276:immunology; D003851:Deoxyribonucleases / Q000097:blood* / Q000276:immunology; D007109:Immunity; D007942:Leukemia, Experimental / Q000097:blood* / Q000276:immunology; D051379:Mice; D008907:Mink
D015415:Biomarkers; D004247:DNA; D003851:Deoxyribonucleases