title: Evaluating genome dynamics: the constraints on rearrangements within bacterial genomes.
abstract: Inversions and translocations distinguish the genomes of closely related bacterial species, but most of these rearrangements preserve the relationship between the rearranged fragments and the axis of chromosome replication. Within species, such rearrangements are found less frequently, except in the case of clinical isolates of human pathogens, where rearrangements are very frequent.
authors.affiliation: Department of Cell and Molecular Biology, Biomedical Center, Uppsala University, S-751 24 Uppsala, Sweden. Diarmaid.Hughes@icm.uu.se
authors.forename: D
authors.initials: D
authors.lastname: Hughes
mesh_terms: D001419:Bacteria / Q000235:genetics*; D015321:Gene Rearrangement / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D010802:Phylogeny; D012336:RNA, Ribosomal, 16S / Q000235:genetics
chemical_list: D012336:RNA, Ribosomal, 16S