Mutagenicity of TCDD in Big Blue transgenic rats.
The compound 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a significant environmental contaminant resulting from such industrial processes as pulp and paper production. TCDD is a suspected human carcinogen and its ability to induce cancer in laboratory rodents is well documented. Its mechanism of tumor initiation, however, is not well understood and in vitro mutagenicity studies have yielded inconsistent results. In this study, Big Blue lacI transgenic rats were used to assess the mutagenicity of TCDD in both male and female animals. After 6 weeks of exposure to 2 microg/kg TCDD neither an increase in mutation frequency nor any change in mutation spectrum was observed in either male or female animals.
Thornton
A S
AS
Centre for Environmental Health, University of Victoria, P.O. Box 3020, Victoria, BC, Canada V8W 3N5.
Oda
Y
Y
Stuart
G R
GR
Glickman
B W
BW
de Boer
J G
JG
D000818:Animals; D030801:Animals, Genetically Modified; D001426:Bacterial Proteins / Q000235:genetics*; D004252:DNA Mutational Analysis; D004785:Environmental Pollutants / Q000633:toxicity*; D029968:Escherichia coli Proteins; D005260:Female; D005787:Gene Frequency; D056968:Lac Repressors; D008297:Male; D009152:Mutagenicity Tests; D009154:Mutation; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D051381:Rats; D012097:Repressor Proteins / Q000235:genetics*; D012737:Sex Factors
D001426:Bacterial Proteins; D004785:Environmental Pollutants; D029968:Escherichia coli Proteins; D056968:Lac Repressors; D000072317:Polychlorinated Dibenzodioxins; D012097:Repressor Proteins