Ca(2+) signaling in dendritic spines.
Dendritic spines are cellular microcompartments that are isolated from their parent dendrites and neighboring spines. Recently, imaging studies of spine Ca(2+) dynamics have revealed that Ca(2+) can enter spines through voltage-sensitive and ligand-activated channels, as well as through Ca(2+) release from intracellular stores. Relationships between spine Ca(2+) signals and induction of various forms of synaptic plasticity are beginning to be elucidated. Measurements of spine Ca(2+) concentration are also being used to probe the properties of single synapses and even individual calcium channels in their native environment.
Sabatini
B L
BL
Howard Hughes Medical Institute, Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11743, USA.
Maravall
M
M
Svoboda
K
K
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D015220:Calcium Channels / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D002451:Cell Compartmentation; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D006801:Humans; D015640:Ion Channel Gating; D017136:Ion Transport; D051379:Mice; D018345:Mice, Knockout; D009419:Nerve Tissue Proteins / Q000502:physiology; D009473:Neuronal Plasticity / Q000502:physiology; D011689:Purkinje Cells / Q000166:cytology / Q000502:physiology; D017966:Pyramidal Cells / Q000166:cytology / Q000502:physiology; D051381:Rats; D011922:Rats, Mutant Strains; D016194:Receptors, N-Methyl-D-Aspartate / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology*
D015220:Calcium Channels; D009419:Nerve Tissue Proteins; D016194:Receptors, N-Methyl-D-Aspartate