Cortical map asymmetries in the context of transcallosal excitatory influences.
There is long-standing disagreement among experimentalists about whether transcallosal interhemispheric influences are primarily excitatory or inhibitory. Past computational models exploring this issue have encountered a similar dilemma: inhibitory callosal influences best explain hemispheric functional asymmetries, but excitatory callosal influences best explain transcallosal diaschisis. We recently hypothesized that this dilemma might be resolved by assuming excitatory callosal influences and a subcortical mechanism for cross-midline inhibition. Here we explore the feasibility of this hypothesis by examining a model of map formation in corresponding left and right cortical regions. The results show for the first time that both map asymmetries and diaschisis-like changes can be produced in a single model, suggesting that subcortical inhibitory processes may contribute more to asymmetric cortical functionality than is generally recognized.
Reggia
J A
JA
Department of Neurology, Institute of Advanced Computer Studies, University of Maryland, College Park 20742, USA.
Goodall
S
S
Levitan
S
S
D001927:Brain Diseases / Q000503:physiopathology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology* / Q000503:physiopathology; D003337:Corpus Callosum / Q000502:physiology* / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology*; D005240:Feasibility Studies; D006801:Humans; D008959:Models, Neurological; D009433:Neural Inhibition / Q000502:physiology