[Genetic consequences of irradiation of one or both parents (results of experiments on Wistar rats) Exitus lethalis in Wistar rat's progeny after irradiation of one or both parents].
Examination of 2563 offsprings of Wistar rats after irradiation of one or both parents with doses of 0.25, 0.5, 1, 2, 3 and 4 Gy was carried out; the manifestation of lethal effects in the progeny of the first generation in ontogenesis was studied. The level of embryonic death was the highest after irradiation of germ cells of parents at stages of spermatids, spermatozoids and matured oocytes. Following irradiation of both parents with doses of 0.25, 0.5 and 1 Gy at these stages of gametogenesis and 4 Gy at the stage of spermatids and matured oocytes there was a trend of increasing radiation effects caused by the participation of two irradiated germ cells. After irradiation of both parents with doses of 2, 3 and 4 Gy the embryonic death F1 was essentially the same as rates for irradiated females and non-irradiated males. The F1 death rate in early postnatal development exceeded the control only after irradiation with doses of 2, 3 and 4 Gy. The increase in radiation effects in the F1 due to the mating of two irradiated parents appears to be associated with a mechanism demonstrating additivity or synergism.
Nefedov
I Iu
IIu
Medical Radiological Research Centre, Russian Academy of Medical Science, Obninsk, 249020 Russia.
Nefedova
I Iu
IIu
Palyga
G F
GF
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D020964:Embryo Loss; D005314:Embryonic and Fetal Development / Q000528:radiation effects*; D005260:Female; D008297:Male; D018811:Maternal Exposure; D018812:Paternal Exposure; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar