Tissue cadmium and locomotor behavior following acute inhalation exposure to cadmium aerosol in rats.
Rats were exposed for 1 h to increasing concentrations of cadmium (Cd) through inhalation of cadmium chloride aerosol using nose-only inhalation chambers and depositions of Cd in lungs, liver and kidneys were measured. Changes in spontaneous locomotor activities were recorded 2 and 7 d after cessation of exposure. A concentration dependent increase in Cd in lungs, liver and kidneys was accompanied by significant alterations in spontaneous locomotor response that was dependent on the air Cd concentrations and the postexposure duration. The study shows decreased spontaneous locomotor activity due to Cd accumulation in tissues.
Dogra
S
S
Industrial Toxicology Research Centre, Lucknow, India.
Khanna
A K
AK
Waseem
M
M
Kaw
J L
JL
D000280:Administration, Inhalation; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002104:Cadmium / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics / Q000633:toxicity*; D003128:Coma / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D004305:Dose-Response Relationship, Drug; D019570:Inhalation Exposure; D007668:Kidney / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D008124:Locomotion / Q000187:drug effects* / Q000502:physiology; D008168:Lung / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism; D011681:Pupil Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D051381:Rats; D012120:Respiration Disorders / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D014018:Tissue Distribution
D002104:Cadmium