Chronic disseminated intravascular coagulation after surgery for abdominal aortic aneurysm: clinical and haemostatic response to dalteparin.
A 77-year-old man developed chronic disseminated intravascular coagulation (DIC) after surgical repair of a large infrarenal aortic aneurysm. Self-administered subcutaneous dalteparin therapy (5000 units o.d.) led to rapid relief of symptoms and sustained improvements in his platelet count and fibrinogen level; activation of coagulation and fibrinolysis appeared to be relatively unaffected. Long-term treatment with low-molecular-weight heparin can provide good symptomatic control of chronic DIC associated with abdominal aortic aneurysm.
Cummins
D
D
Royal Brompton & Harefield NHS Trust, Harefield, Middlesex, UK. david_cummins@talk21.com
Segal
H
H
Hunt
B J
BJ
Awad
R
R
Maddox
A
A
D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D000991:Antithrombins / Q000032:analysis; D017544:Aortic Aneurysm, Abdominal / Q000097:blood / Q000150:complications / Q000601:surgery*; D002908:Chronic Disease; D017985:Dalteparin / Q000627:therapeutic use*; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000188:drug therapy*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D015696:Gene Products, tat / Q000032:analysis; D006801:Humans; D008297:Male; D010958:Plasminogen / Q000032:analysis; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D010976:Platelet Count; D011183:Postoperative Complications / Q000097:blood / Q000188:drug therapy*; D011516:Prothrombin / Q000032:analysis; D010959:Tissue Plasminogen Activator / Q000032:analysis
D000925:Anticoagulants; D000991:Antithrombins; D005338:Fibrin Fibrinogen Degradation Products; D015696:Gene Products, tat; D017395:Plasminogen Activator Inhibitor 1; C036309:fibrin fragment D; D011516:Prothrombin; D010958:Plasminogen; D010959:Tissue Plasminogen Activator; D017985:Dalteparin