title: The Dual Role of Nitric Oxide in Islet beta-Cells.
abstract: In pancreatic islets, nitric oxide (NO) produced on exposure to cytokines mediates beta-cell injury leading to diabetes mellitus. On the other hand, L-arginine-derived NO may participate in the signal transduction pathway of physiological insulin secretion. This review focuses on the dual role of NO as a mediator of physiological and pathophysiological processes in pancreatic islets.
authors.affiliation: Division of Endocrinology and Diabetes, Department of Internal Medicine, University Hospital, CH-8091 Zürich, Switzerland.
authors.forename: Giatgen A.
authors.initials: GA
authors.lastname: Spinas