title: Trisomy 8 as sole karyotypic aberration in an ovarian metastasizing Sertoli-Leydig cell tumor.
abstract: Sertoli-Leydig cell tumors (SLCTs) represent a rare group of sex-cord stromal tumors of the ovary of unknown pathogenesis. We report a SLCT of intermediate differentiation with peritoneal recurrence and lymph node metastasis 12 months after removal, including cytogenetic analysis by comparative genomic hybridization and fluorescence in situ hybridization, which showed trisomy 8 as sole unbalanced karyotypic aberration. Our results provide evidence that a simple numeric chromosomal abnormality in SLCT may be associated with a malignant phenotype and suggest that the molecular pathogenesis of SLCT may be different from ovarian granulosa-stromal cell tumors.
authors.affiliation: Institute of Pathology and Department of Gynecology and Obstetrics, Medical Faculty, Technical University of Aachen, Aachen, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Manegold
authors.forename: L
authors.initials: L
authors.lastname: Tietze
authors.forename: K
authors.initials: K
authors.lastname: Günther
authors.forename: A
authors.initials: A
authors.lastname: Fleischer
authors.forename: B K
authors.initials: BK
authors.lastname: Amo-Takyi
authors.forename: W
authors.initials: W
authors.lastname: Schröder
authors.forename: S
authors.initials: S
authors.lastname: Handt
mesh_terms: D000293:Adolescent; D002898:Chromosomes, Human, Pair 8; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis / Q000235:genetics*; D009364:Neoplasm Recurrence, Local; D009693:Nucleic Acid Hybridization; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D010537:Peritoneum / Q000473:pathology; D018310:Sertoli-Leydig Cell Tumor / Q000235:genetics* / Q000473:pathology / Q000601:surgery; D014314:Trisomy