title: Greater effect of dietary potassium tripolyphosphate than of potassium dihydrogenphosphate on the nephrocalcinosis and proximal tubular function in female rats from the intake of a high-phosphorus diet.
abstract: We examined whether a difference in potassium dihydrogenphosphate (KH2PO4) and potassium tripolyphosphate (K5P3O10) as dietary phosphorus sources could differentially effect the nephrocalcinosis and proximal tubular function in female rats. Rats were fed on a diet containing KH2PO4 or K5P3O10, at the normal phosphorus level (normal phosphorus diet) or at a high phosphorus level (high-phosphorus diet) for 21 d. Nephrocalcinosis, as confirmed by a histological examination, was apparent in all rats fed on the high-phosphorus diet, and this condition was more severe in those rats fed on K5P3O10 than in those fed on KH2PO4. As indicators of the proximal tubular function, the N-acetyl-beta-D-glucosaminidase activity in urine and the urinary beta2-microglobulin excretion were significantly increased in those rats fed on the high-phosphorus diet containing K5P3O10. These results indicate that the intake of a high-phosphorus diet, more strongly influenced the nephrocalcinosis and proximal tubular function when K5P3O10 rather than KH2PO4 was used as the dietary phosphorus source.
authors.affiliation: Department of Nutrition, Junior College of Tokyo University of Agriculture, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Matsuzaki
authors.forename: R
authors.initials: R
authors.lastname: Masuyama
authors.forename: M
authors.initials: M
authors.lastname: Uehara
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007687:Kidney Tubules, Proximal / Q000737:chemistry / Q000503:physiopathology*; D008903:Minerals / Q000494:pharmacology; D009397:Nephrocalcinosis / Q000378:metabolism / Q000503:physiopathology*; D010710:Phosphates / Q000494:pharmacology*; D016226:Phosphorus, Dietary / Q000494:pharmacology*; D011122:Polyphosphates / Q000494:pharmacology*; D017680:Potassium Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D008903:Minerals; D010710:Phosphates; D016226:Phosphorus, Dietary; D011122:Polyphosphates; D017680:Potassium Compounds; C013216:potassium phosphate; C005692:triphosphoric acid