Evidence for a correlation between antibody-dependent cellular cytotoxicity-mediating anti-HIV-1 antibodies and prognostic predictors of HIV infection.
Using our gp120/41-expressing, NK cell activity-resistant CEM.NKR cell clones as targets in HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) assays, we demonstrate here that the serum titers of anti-HIV-1 ADCC antibodies bear a significant (P < 0.05) positive correlation with the peripheral blood CD4+ T cell counts and a negative one with the number of copies of HIV-1 RNA in the plasma of HIV-infected individuals. These findings underscore the importance of these antibodies as a protective immune parameter in these infections.
Ahmad
R
R
Pediatric Research Center, Ste-Justine Hospital, Montreal, QC, Canada. ahmada@justine.umontreal.ca
Sindhu
S T
ST
Toma
E
E
Morisset
R
R
Vincelette
J
J
Menezes
J
J
Ahmad
A
A
D000920:Antibody-Dependent Cell Cytotoxicity; D018791:CD4 Lymphocyte Count; D002999:Clone Cells; D015483:HIV Antibodies / Q000097:blood*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D015497:HIV-1 / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D011379:Prognosis; D012367:RNA, Viral / Q000097:blood; D014766:Viremia / Q000276:immunology / Q000821:virology
D015483:HIV Antibodies; D012367:RNA, Viral