title: The association of fatty acids with prostate cancer risk.
abstract: BACKGROUND
  Animal studies indicate that omega-6 fatty acids promote and omega-3 fatty acids inhibit tumor development. This pilot study was designed to evaluate whether these fatty acids are associated with human prostate cancer.
  
  
  METHODS
  Levels of erythrocyte membrane omega-3 and omega-6 fatty acids were determined for 67 incident prostate cancer cases and 156 population-based controls.
  
  
  RESULTS
  Prostate cancer risk was increased in the highest compared to the lowest quartile of alpha-linolenic acid (OR = 2.6, 95% CI = 1.1-5.8, trend P = 0.01). Positive associations were also observed with higher levels of linoleic acid (OR = 2.1, 95% CI = 0.9-4.8) and total omega-6 fatty acids (OR = 2.3, 95% CI = 1.0-5.4).
  
  
  CONCLUSIONS
  Results are consistent with other studies showing that linoleic and total omega-6 fatty acids increase risk of prostate cancer. Contrary to animal studies, alpha-linolenic acid was also positively associated with risk. Further research will be required to clarify the role of these fatty acids in human prostate cancer.
authors.affiliation: Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington 98109-1024, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Newcomer
authors.forename: I B
authors.initials: IB
authors.lastname: King
authors.forename: K G
authors.initials: KG
authors.lastname: Wicklund
authors.forename: J L
authors.initials: JL
authors.lastname: Stanford
mesh_terms: D000230:Adenocarcinoma / Q000097:blood* / Q000453:epidemiology; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D016022:Case-Control Studies; D004041:Dietary Fats / Q000009:adverse effects; D004910:Erythrocyte Membrane / Q000378:metabolism; D015525:Fatty Acids, Omega-3 / Q000097:blood*; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011471:Prostatic Neoplasms / Q000097:blood* / Q000453:epidemiology; D012307:Risk Factors; D018709:Statistics, Nonparametric
chemical_list: D014408:Biomarkers, Tumor; D004041:Dietary Fats; D015525:Fatty Acids, Omega-3; D043371:Fatty Acids, Omega-6; D005231:Fatty Acids, Unsaturated