The role of matrix metalloproteinases in tumor invasion, metastasis, and angiogenesis.
Tumor invasion and metastasis formation are the hallmarks of malignant cancer. Metastatic spread of cancer cells is a result of a complex cascade of cellular events. This article discusses the matrix metalloproteinase family, the regulation of matrix metalloproteinase activity, and the functions of matrix metalloproteinases in tumor progression.
Stetler-Stevenson
W G
WG
Extracellular Matrix Pathology Section, Laboratory of Pathology, Division of Clinical Sciences, National Cancer Institute, Bethesda, Maryland 20892-1500, USA. sstevenw@mail.nih.gov
D018450:Disease Progression; D006801:Humans; D020782:Matrix Metalloproteinases / Q000737:chemistry / Q000502:physiology*; D009361:Neoplasm Invasiveness / Q000235:genetics* / Q000503:physiopathology*; D009362:Neoplasm Metastasis / Q000235:genetics* / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000201:enzymology*
D020782:Matrix Metalloproteinases