In vitro evaluation of 2,4-dihydroxythiobenzanilides against various moulds.
The antimycotic potency of 2,4-dihydroxythiobenzanilide derivatives was tested. The MIC assessments by an agar dilution method were used for the estimation of potential activity in vitro against the four mould strains: Scopulariopsis brevicalis, Aspergillus niger, Aspergillus fumigatus and Penicillium sp. The strongest fungistatic activity was observed for 3'-fluoro-derivative (MIC 7.82 microg/ml). It was stated that the inhibition action of these compounds depends mainly on lipophilicity of molecules. Parabolic relationships between the antimycotic activity and lipophilicity were found.
Niewiadomy
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A
Department of Chemistry, University of Agriculture, Akademicka 15, 20-950 Lublin, Poland. jmaty@agros.ar.lublin.pl
Matysiak
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J
Macik-Niewiadomy
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G
D000813:Anilides / Q000138:chemical synthesis* / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D001232:Aspergillus fumigatus / Q000187:drug effects; D001234:Aspergillus niger / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005658:Fungi / Q000187:drug effects*; D008055:Lipids / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D008968:Molecular Conformation; D010407:Penicillium / Q000187:drug effects; D013329:Structure-Activity Relationship
D000813:Anilides; D000935:Antifungal Agents; D008055:Lipids