In vitro studies of the efficacy of antimicrobials against fungi.
OBJECTIVE
The purpose of this study was to compare the efficacy of Listerine Antiseptic, Tartar Control Listerine Antiseptic, and Peridex mouthrinses and a 0.2% chlorhexidine digluconate solution against known pathogenic fungi.


METHODS
Standardized methods were used to compare the antimicrobial efficacy of the above agents versus representative fungal species. Minimum inhibitory concentration-minimum fungicidal concentrations in macrobroth dilutions, suspension kill-time, and effectiveness against an artificial biofilm-attached population were studied.


RESULTS
All antimicrobials tested were effective against the fungal species under investigation at the concentration available commercially. Listerine Antiseptic showed a greater efficacy against attached artificial biofilm populations than the other antimicrobials tested.


CONCLUSIONS
Listerine Antiseptic, Tartar Control Listerine Antiseptic, and Peridex mouthrinses show promise as a means to control the pathogenic fungal species under investigation and may have applications to reduce oral colonization.
Meiller
T F
TF
Department of Oral Medicine and Diagnostic Sciences, Unversity of Maryland Dental School, Balitmore, Md 21201, USA. TFM001@dental.umaryland.edu
Kelley
J I
JI
Jabra-Rizk
M A
MA
Depaola
L G
LG
Baqui
A A
AA
Falkler
W A
WA
D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D018441:Biofilms / Q000187:drug effects; D002175:Candida / Q000145:classification / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004338:Drug Combinations; D004352:Drug Resistance, Microbial; D005658:Fungi / Q000187:drug effects* / Q000472:pathogenicity; D006801:Humans; D008826:Microbial Sensitivity Tests; D009055:Mouth / Q000382:microbiology; D009067:Mouthwashes / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012459:Salicylates / Q000494:pharmacology; D013170:Spores / Q000187:drug effects; D013223:Statistics as Topic; D013729:Terpenes / Q000494:pharmacology; D013997:Time Factors
D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D009067:Mouthwashes; D012459:Salicylates; D013729:Terpenes; C057473:Listerine; C010882:chlorhexidine gluconate; D002710:Chlorhexidine