The effect of coenzyme Q10 on blood ascorbic acid, vitamin E, an lipid peroxide in chronic cadmium intoxication.
The aim of our study was to investigate the possible protective role of coenzyme Q10 (CoQ10) administration on ascorbic acid (AsA), vitamin E (vit E), and lipid peroxide (LP) concentrations in the blood of rats chronically treated with cadmium. Results were compared to those obtained in control animals, as well as to those obtained in animals treated with olive oil. Compared to that of the control animals, the AsA concentration was significantly increased in rats treated with CoQ10 and olive oil, whereas vit E concentration was significantly increased in animals treated with cadmium, CoQ10, or cadmium + CoQ10. A significant decrease in LP concentration was noted in animals treated with cadmium or with cadmium + CoQ10o, whereas a significant increase was seen in animals treated with olive oil. Compared to that of the animals treated with olive oil, the ascorbic acid concentration was significantly decreased in rats treated with cadmium or with cadmium + CoQ10, whereas vit E concentration was significantly increased in animals treated with cadmium, CoQ10, or cadmium + CoQ10. LP concentration was significantly decreased in rats treated with cadmium, CoQ10, or cadmium + CoQ10. Our study showed that CoQ10 administration in rats chronically exposed to exogenous cadmium exerts beneficial effects on the nonenzymatic components of the antioxidant defense system, such as AsA and vit E, resulting in a decreased concentration of LP in the blood.
Pavlović
S Z
SZ
Department of Physiology , Institute for Biological Research Sinisa Stanković, Belgrade, Yugoslavia. sladjan@ibiss.bg.ac.yu
Ognjanović
B I
BI
Stajn
A S
AS
Zikić
R V
RV
Saicić
Z S
ZS
Petrović
V M
VM
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood*; D019256:Cadmium Chloride / Q000633:toxicity*; D003067:Coenzymes; D019610:Cytoprotection / Q000502:physiology*; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology*; D014810:Vitamin E / Q000097:blood*
D003067:Coenzymes; D017392:Thiobarbituric Acid Reactive Substances; D014451:Ubiquinone; D014810:Vitamin E; C024989:coenzyme Q10; D019256:Cadmium Chloride; D001205:Ascorbic Acid