Case report on hereditary non-polyposis colon cancer (HNPCC) in Nigeria.
The role of genetic factors in the etiology of colorectal cancers (CRCs) has recently been elucidated with the discovery of the mismatch repair. These genes are responsible for less than 5% of all cases of CRCs in Caucasian series. In this pilot study, tumors from 5 randomly ascertained CRC patients were subjected to microsatellite analysis, and two were microsatellite unstable. Both of these two patients had germline mutations in MSH2. If this finding can be confirmed in a larger series of patients, it suggests that MMR genes play an important role in the etiology of CRCs in Africa.
Adebamowo
C A
CA
Department of Surgery and Pathology, University College Hospital, Ibadan, Nigeria. adebamowo@alpha.linkserve.com
Adeyi
O
O
Pyatt
R
R
Prior
T W
TW
Chadwick
R B
RB
de la Chapelle
A
A
D000368:Aged; D044383:Black People / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000175:diagnosis* / Q000453:epidemiology / Q000235:genetics*; D004268:DNA-Binding Proteins; D017809:Fatal Outcome; D018095:Germ-Line Mutation / Q000235:genetics; D006801:Humans; D015994:Incidence; D008297:Male; D018895:Microsatellite Repeats / Q000235:genetics; D008875:Middle Aged; D051718:MutS Homolog 2 Protein; D009549:Nigeria / Q000453:epidemiology; D010865:Pilot Projects; D016133:Polymerase Chain Reaction; D011518:Proto-Oncogene Proteins / Q000235:genetics; D044465:White People / Q000235:genetics
D004268:DNA-Binding Proteins; D011518:Proto-Oncogene Proteins; C497172:MSH2 protein, human; D051718:MutS Homolog 2 Protein