In vitro antibiotic susceptibilities of Burkholderia mallei (causative agent of glanders) determined by broth microdilution and E-test.
In vitro susceptibilities to 28 antibiotics were determined for 11 strains of Burkholderia mallei by the broth microdilution method. The B. mallei strains demonstrated susceptibility to aminoglycosides, macrolides, quinolones, doxycycline, piperacillin, ceftazidime, and imipenem. For comparison and evaluation, 17 antibiotic susceptibilities were also determined by the E-test. E-test values were always lower than the broth dilution values. Establishing and comparing antibiotic susceptibilities of specific B. mallei strains will provide reference information for assessing new antibiotic agents.
Heine
H S
HS
Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases, Frederick, Maryland 21702-5011, USA. henry.heine@det.amedd.army.mil
England
M J
MJ
Waag
D M
DM
Byrne
W R
WR
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019117:Burkholderia / Q000187:drug effects* / Q000302:isolation & purification; D019121:Burkholderia Infections / Q000382:microbiology; D003470:Culture Media / Q000494:pharmacology; D005896:Glanders / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods
D000900:Anti-Bacterial Agents; D003470:Culture Media