title: Scintigraphy and Doppler ultrasonography for the evaluation of obstructive urinary calculi.
abstract: Forty-seven patients with unilateral obstructive calculi (12 males and 35 females) were submitted to 99mTc-diethylene triamine pentaacetic acid (DTPA) or 99mTc-dimercaptosuccinic acid (DMSA) scans for assessment of renal function. The scans revealed unilateral functional deficit in 68 and 66% of the patients, respectively. A calculus size of 1.1 to 2.0 cm was significantly associated with deficit detected by DTPA, but duration of obstruction and calculus localization were not. After relief of the obstruction, the mean percent renal function of the affected kidney was found to be significantly increased from 25 +/- 12% to 29 +/- 12% in DTPA and from 21 +/- 15% to 24 +/- 12% in DMSA. Initial Doppler ultrasonography performed in 35 patients detected an increased resistive index in 10 (29%). In the remaining patients with a normal resistive index, ureteral urinary jet was observed, indicating partial obstruction. The high frequency of renal function impairment detected by DTPA and of tubulointerstitial damage detected by DMSA as well as the slight amelioration of unilateral renal function after relief of obstruction suggest that scintigraphy assessment may help evaluate the unilateral percentage of renal function and monitor renal function recovery when it occurs. The presence of a urinary jet detected by Doppler ultrasonography further indicates the severity of obstruction and the recovery prognosis.
authors.affiliation: Divisão de Nefrologia, Escola Paulista de Medicina, Universidade Federal de São Paulo, Rua Botucatu, 740, 04023-900 São Paulo, SP, Brazil.
authors.forename: L
authors.initials: L
authors.lastname: Gandolpho
authors.forename: M
authors.initials: M
authors.lastname: Sevillano
authors.forename: A
authors.initials: A
authors.lastname: Barbieri
authors.forename: S
authors.initials: S
authors.lastname: Ajzen
authors.forename: N
authors.initials: N
authors.lastname: Schor
authors.forename: V
authors.initials: V
authors.lastname: Ortiz
authors.forename: I P
authors.initials: IP
authors.lastname: Heilberg
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D016284:Technetium Tc 99m Pentetate; D018608:Ultrasonography, Doppler / Q000379:methods; D014517:Ureteral Obstruction / Q000000981:diagnostic imaging*; D014545:Urinary Calculi / Q000000981:diagnostic imaging*
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D016284:Technetium Tc 99m Pentetate