title: Natural and synthetic benzophenones: interaction with the cytosolic binding domain of P-glycoprotein.
abstract: A benzophenone glycoside has been isolated from Davallia solida. Its structure was elucidated by chemical and spectral means as 4-O-beta-D-glucopyranosyl-2,6,4'-trihydroxybenzophenone. It bound with moderate affinity to the purified C-terminal cytosolic domain of P-glycoprotein, but the binding affinity was 6- to 10-fold increased for its aglycone derivative and other related benzophenones.
authors.affiliation: Laboratory of Pharmacognosy, Faculty of Pharmacy, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Rancon
authors.forename: A
authors.initials: A
authors.lastname: Chaboud
authors.forename: N
authors.initials: N
authors.lastname: Darbour
authors.forename: G
authors.initials: G
authors.lastname: Comte
authors.forename: C
authors.initials: C
authors.lastname: Bayet
authors.forename: P N
authors.initials: PN
authors.lastname: Simon
authors.forename: J
authors.initials: J
authors.lastname: Raynaud
authors.forename: A
authors.initials: A
authors.lastname: Di Pietro
authors.forename: P
authors.initials: P
authors.lastname: Cabalion
authors.forename: D
authors.initials: D
authors.lastname: Barron
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D001577:Benzophenones / Q000138:chemical synthesis / Q000302:isolation & purification / Q000378:metabolism*; D001665:Binding Sites / Q000502:physiology; D001685:Biological Factors / Q000302:isolation & purification / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism*; D019008:Drug Resistance, Neoplasm; D010936:Plant Extracts; D017434:Protein Structure, Tertiary / Q000502:physiology
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001577:Benzophenones; D001685:Biological Factors; D010936:Plant Extracts