Smooth muscle excitation-contraction coupling: a role for caveolae and caveolins?
Agonist stimulation of smooth muscle contractility involves integration of many signal-transducing events from the plasma membrane to myofilaments in the cytoplasm. Recent evidence suggests an important role for membranous invaginations termed caveolae, and their integral protein components caveolins, in the coordination of extracellular contractile stimuli and intracellular effectors in smooth muscle.
Taggart
M J
MJ
Department of Medicine and Maternal and Fetal Health Research Centre, University of Manchester, Manchester Royal Infirmary, Manchester M13 9WL, England.
D000818:Animals; D022461:Caveolins / Q000502:physiology*; D002462:Cell Membrane / Q000737:chemistry / Q000502:physiology / Q000648:ultrastructure; D009119:Muscle Contraction / Q000502:physiology*; D009130:Muscle, Smooth / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
D022461:Caveolins