title: Combined topical flucytosine and amphotericin B for refractory vaginal Candida glabrata infections.
abstract: Patients with vaginitis due to highly azole resistant Candida glabrata can be particularly difficult to treat. We describe three cases of longstanding vaginal candidiasis due to C glabrata. These had failed to respond to local and systemic antifungals. Flucytosine (1 g) and amphotericin B (100 mg) formulated in lubricating jelly base in a total 8 g delivered dose, was used per vagina once daily for 14 days with significant improvement, both clinically and microbiologically.
authors.affiliation: Department of Sexual Medicine, Birmingham Heartlands Hospital, Birmingham B9 5SS, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: White
authors.forename: A R
authors.initials: AR
authors.lastname: Habib
authors.forename: A
authors.initials: A
authors.lastname: Vanthuyne
authors.forename: S
authors.initials: S
authors.lastname: Langford
authors.forename: M
authors.initials: M
authors.lastname: Symonds
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000382:microbiology; D004338:Drug Combinations; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage*; D006801:Humans; D008875:Middle Aged
chemical_list: D000935:Antifungal Agents; D004338:Drug Combinations; D000666:Amphotericin B; D005437:Flucytosine