title: Snake toxins that bind specifically to individual subtypes of muscarinic receptors.
abstract: This paper discusses the properties of the three most specific ligands found for the extracellular faces of M1, M2 and M4 muscarinic receptors (m1-toxin1, m2-toxin and m4-toxin, respectively). The primary goal of this paper is to show the known and potential usefulness of these toxins and their biotinylated, radioactive, fluorescent and mutated derivatives.
authors.affiliation: Department of Molecular and Cellular Pharmacology, University of Miami School of Medicine, FL 33101, USA. lpotter@miami.edu
authors.forename: L T
authors.initials: LT
authors.lastname: Potter
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004546:Elapid Venoms / Q000737:chemistry / Q000378:metabolism* / Q000494:pharmacology; D017815:Elapidae / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D018727:Muscarinic Antagonists / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D009498:Neurotoxins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D011485:Protein Binding; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D043588:Receptor, Muscarinic M4; D011976:Receptors, Muscarinic / Q000378:metabolism*; D016415:Sequence Alignment
chemical_list: D004546:Elapid Venoms; D018727:Muscarinic Antagonists; D009498:Neurotoxins; D043643:Receptor, Muscarinic M1; D043585:Receptor, Muscarinic M2; D043588:Receptor, Muscarinic M4; D011976:Receptors, Muscarinic; C083667:m1-toxin; C400107:m2-toxin; C098184:muscarinic toxin MT4