Functional role of a glycolipid in directional movements of neurons.
Migration of neurons from their site of origin to their final destination is a critical and universal step in the formation of the complex structure of the nervous system. The migratory process is thought to be governed in part by genetically and epigenetically defined sequences of signals which are interpreted by migrating cells. The molecular mechanisms that underlie neuronal migration have been the subject of intense investigation. As in other developmental processes, many molecules must participate in neuronal migration. Some molecules, such as cell adhesion molecules and motor proteins, may contribute to discrete steps in the migration act; others, like extracellular signaling molecules, may regulate the activation and/or termination of the migration program. In this article we review findings from our group that demonstrate the functional role(s) of a specific glycolipid in neuronal migration and neurite outgrowth in the developing and adult nervous system.
Mendez-Otero
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Laboratório de Neurobiologia Celular e Molecular, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, 21944-970 Rio de Janeiro, Brazil. rmotero@biof.ufrj.br
Santiago
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D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D005732:Gangliosides / Q000502:physiology*; D009414:Nerve Growth Factors; D019006:Neural Cell Adhesion Molecules / Q000502:physiology; D016501:Neurites / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D051381:Rats; D013687:Telencephalon / Q000502:physiology
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D005732:Gangliosides; D009414:Nerve Growth Factors; D019006:Neural Cell Adhesion Molecules; C049132:9-O-acetyl-GD3 ganglioside