Evaluation of [(99m)Tc] liposomes as lymphoscintigraphic agents: comparison with [(99m)Tc] sulfur colloid and [(99m)Tc] human serum albumin.
This study investigates the use of [(99m)Tc] liposomes for the detection of sentinel lymph nodes. A variety of [(99m)Tc] liposome formulations were compared with common lymphoscintigraphic agents including [(99m)Tc] regular-sulfur colloid (SC), [(99m)Tc] 0.22 microfiltered-SC, [(99m)Tc] reduced heating time 0.22 microfiltered-SC, and [(99m)Tc] human serum albumin (HSA) in rabbits. Images were acquired for the first 60 minutes and at 24 hours, followed by tissue biodistribution study. All agents except [(99m)Tc] regular SC demonstrated good migration from the injection site. Agents were retained in the popliteal node at 24 hours to varying degrees as follows: both [(99m)Tc] filtered SC preparations > [(99m)Tc] regular SC > [(99m)Tc] liposomes > [(99m)Tc] HSA. [(99m)Tc] liposome imaging can be used to develop novel liposome compositions with improved lymph node diagnostic and drug delivery characteristics.
Phillips
W T
WT
Radiology Department, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA. phillips@uthscsa.edu
Andrews
T
T
Liu
H
H
Klipper
R
R
Landry
A J
AJ
Blumhardt
R
R
Goins
B
B
D000818:Animals; D004337:Drug Carriers; D015902:Gamma Cameras; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008081:Liposomes; D008198:Lymph Nodes / Q000000981:diagnostic imaging; D061305:Lymphoscintigraphy; D008297:Male; D010316:Particle Size; D011817:Rabbits; D019275:Radiopharmaceuticals / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D013671:Technetium Tc 99m Sulfur Colloid / Q000008:administration & dosage* / Q000493:pharmacokinetics*
D004337:Drug Carriers; D008081:Liposomes; D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; D013671:Technetium Tc 99m Sulfur Colloid