title: Increased uptake of 99Tcm-ethyl cysteinate dimer in patients with brain tumours.
abstract: We performed 229 99Tcm-ethyl cysteinate dimer (ECD) single photon emission tomography (SPET) studies in 185 patients with brain tumour. Increased uptake of the tracer was observed in 11 cases. In six of these 11 patients, focal intense activity was seen in the area surrounding the tumour. Five of these six patients had episodes of seizure, and ictal SPET showed further increased uptake in the area of hyperperfusion in one patient. Hyperperfusion surrounding the tumour might be related to seizure. In the remaining five patients, increased accumulation was seen in the tumour. Three of these five patients had a discrepancy between 99Tcm-ECD SPET and 201Tl SPET imaging. There could be some difference in the mechanism of accumulation in the tumour between 99Tcm-ECD and 201Tl.
authors.affiliation: Department of Radiology, Nagasaki University School of Medicine, Sakamoto, Japan. yoogawa@net.nagasaki-u.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Ogawa
authors.forename: R
authors.initials: R
authors.lastname: Hashmi
authors.forename: A
authors.initials: A
authors.lastname: Aziz
authors.forename: M
authors.initials: M
authors.lastname: Ochi
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001254:Astrocytoma / Q000000981:diagnostic imaging / Q000601:surgery; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000556:secondary / Q000601:surgery; D003545:Cysteine / Q000031:analogs & derivatives / Q000493:pharmacokinetics*; D005260:Female; D005909:Glioblastoma / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D008297:Male; D008579:Meningioma / Q000000981:diagnostic imaging / Q000601:surgery; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000000981:diagnostic imaging; D009837:Oligodendroglioma / Q000000981:diagnostic imaging / Q000601:surgery; D015609:Organotechnetium Compounds / Q000493:pharmacokinetics*; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C059659:technetium Tc 99m bicisate; D003545:Cysteine