title: The influence of two different dental local anaesthetic solutions on the haemodynamic responses of children undergoing restorative dentistry: a randomised, single-blind, split-mouth study.
abstract: OBJECTIVE
  This investigation was designed to study the haemodynamic effects of two different local anaesthetic solutions during restorative dental treatment in children.
  
  
  METHODS
  A randomised, single-blind, split-mouth cross-over design was employed using children undergoing bilaterally similar restorative treatments over two visits.
  
  
  METHODS
  The study was performed in a dental hospital paediatric dentistry department.
  
  
  METHODS
  Ten children participated. At one visit the local anaesthetic was 2% lidocaine (lignocaine) with 1:80,000 epinephrine (adrenaline); at the other the anaesthetic was 3% prilocaine with 0.03IU/ml felypressin. Local anaesthetic was administered at a dose of 0.5 ml/10 kg body weight. Blood pressure and heart rate were measured before and during treatment with an automatic blood pressure recorder. Data were analysed by ANOVA and Student's paired t test.
  
  
  RESULTS
  Significant differences between treatments in diastolic blood pressure (F = 2.37; P = 0.05) and heart rate (F = 2.98; P< 0.02) were noted. The heart rate increased ten minutes following the injection of the epinephrine-containing solution. The diastolic blood pressure fell 20 minutes after injection of lidocaine with epinephrine.
  
  
  CONCLUSIONS
  The choice of local anaesthetic solution influences the haemodynamic response during restorative treatment in children.
authors.affiliation: Department of Oral and Maxillofacial Surgery, The Dental School, University of Newcastle Upon Tyne. J.G.Meechan@ncl.ac.uk
authors.forename: J G
authors.initials: JG
authors.lastname: Meechan
authors.forename: B
authors.initials: B
authors.lastname: Cole
authors.forename: R R
authors.initials: RR
authors.lastname: Welbury
mesh_terms: D000704:Analysis of Variance; D000766:Anesthesia, Dental; D000779:Anesthetics, Local / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002648:Child; D019140:Dental Care for Children; D003793:Dental Restoration, Permanent; D004837:Epinephrine / Q000494:pharmacology*; D005259:Felypressin / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D011318:Prilocaine / Q000494:pharmacology*; D016037:Single-Blind Method; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D014662:Vasoconstrictor Agents; D011318:Prilocaine; D005259:Felypressin; D008012:Lidocaine; D004837:Epinephrine