[Anterior uveitis and cidofovir].
OBJECTIVE
This retrospective study was designed to determine the different parameters involved in the occurrence of uveitis during treatment with codofovir.


METHODS
This study included 10 patients out of 13 treated with cidofovir for cytomegalovirus (CMV) disease. Ocular examination, CD4+ lymphocyte count, and creatinine clearance were performed for each case of uveitis.


RESULTS
During the 17-month study, 20 uveitis cases were analyzed. The first attack occurred after a median interval of 7.6 doses. At the time of ocular inflammation, 65% of the cases had a CD4+ lymphocyte count >=100x10(6)/L, the patients thus had an improved immune function. Half of the patients had a normal creatinine clearance. The patients with a CD4+ lymphocyte count<100x10(6)/L who presented one or more incidents of uveitis had an abnormal clearance, thus probably inducing intraocular storage of the drug.


CONCLUSIONS
The occurrence of anterior uveitis during treatment with cidofovir is induced by the association of several parameters: a previous history of CMV retinitis, improvement of the immune function state, and intraocular storage of the drug.
Rougier
M B
MB
Service d'Ophtalmologie, Centre Hospitalier Universitaire, Hôpital Pellegrin, Place Amélie Raba-Léon, 33076 Bordeaux Cedex.
Neau
D
D
Viallard
J F
JF
Ragnaud
J M
JM
Lacut
Y
Y
Korobelnik
J F
JF
Le Rebeller
M J
MJ
D017088:AIDS-Related Opportunistic Infections / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D000328:Adult; D018791:CD4 Lymphocyte Count; D000077404:Cidofovir; D003404:Creatinine / Q000378:metabolism; D017726:Cytomegalovirus Retinitis / Q000097:blood / Q000188:drug therapy* / Q000378:metabolism; D003596:Cytosine / Q000009:adverse effects* / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D009887:Ophthalmoscopy; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000009:adverse effects*; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors; D014018:Tissue Distribution; D014606:Uveitis, Anterior / Q000139:chemically induced* / Q000175:diagnosis
D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D003404:Creatinine; D000077404:Cidofovir