[Effect of improved topical agents on healing time of deep second-degree burn wound].
OBJECTIVE
With the recognization of the mechanism of wound healing, some topical agents are created and applied in trauma to improve the healing rate of wounds. The main purpose of this study is to investigate the effect of some topical agents on the healing rate of deep second-degree burn wounds.


METHODS
One thousand five hundred and sixty-three patients with deep second-degree burn wounds(total burn surface area < or = 10%) were involved in this study from January 1982 to December 1999. According to the application time of different treating measures including supplement of Zn, application of growth factors and collagenase, the patients were divided into 3 groups, wound healing rates were compared.


RESULTS
Before 1991, none of special topical agents were used, and the healing time of deep second-degree burn wounds was(23.8 +/- 3.5) days. From 1991 to 1996, with the topical application of SD-Ag-Zn, which can provide Zn for cells taking part in wound healing, the healing time of deep second-degree burn wounds was (20.6 +/- 3.2) days, earlier than no special topical agents (P < 0.05). From 1997 to 1999, growth factors such as basic fibroblast growth factor(bFGF) and epithelial growth factor (EGF) and collagenases were applied in wound treatment combining with SD-Ag-Zn, wound healing time was (16.2 +/- 2.8) days, earlier than no special topical agents (P < 0.01) and simple SD-Ag-Zn application (P < 0.05).


CONCLUSIONS
It indicates that the improvement of topical agents can accelerate wound healing speed.
Yang
H M
HM
Burn Institute, 304th Hospital of PLA. Beijing, P. R. China 100037. hmyang@sohu.com
Chai
J K
JK
Guo
Z R
ZR
D000293:Adolescent; D000328:Adult; D002056:Burns / Q000188:drug therapy*; D002648:Child; D017364:Collagenases / Q000627:therapeutic use*; D005260:Female; D006133:Growth Substances / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014945:Wound Healing / Q000187:drug effects*; D015032:Zinc / Q000627:therapeutic use*
D006133:Growth Substances; D017364:Collagenases; D015032:Zinc