title: Computational fluid dynamics as a development tool for rotary blood pumps.
abstract: Computational fluid dynamics (CFD) is beginning to significantly impact the development of biomedical devices, in particular rotary cardiac assist devices. The University of Pittsburgh's McGowan Center for Artificial Organ Development has extensively used CFD as the primary tool to analyze and design a novel axial flow blood pump having a magnetically suspended rotor. The blood-contacting surfaces of the pump were developed using a design strategy based on CFD that involved closely coupling a Navier-Stokes solver to a parameterized geometry modeler and advanced mesh movement techniques. CFD-based blood damage models for shear-induced hemolysis as well as surrogate functions describing thrombosis potential were employed to help guide design improvements. This CFD-based design approach resulted in the timely development of a pump subjected to multiple geometric refinements without building expensive physical prototypes for each design iteration. A physical prototype of the final improved pump was fabricated and experimentally analyzed using particle imaging flow visualization. The CFD predicted results correlated well with the experimental data including pressure-flow (H-Q) performance and specific flow field features. It is estimated that the present CFD-based design approach shortened the overall design time frame from an order of years to months.
authors.affiliation: McGowan Center for Artificial Organ Development, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. gwbl@pitt.edu
authors.forename: G W
authors.initials: GW
authors.lastname: Burgreen
authors.forename: J F
authors.initials: JF
authors.lastname: Antaki
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Wu
authors.forename: A J
authors.initials: AJ
authors.lastname: Holmes
mesh_terms: D019295:Computational Biology; D003198:Computer Simulation; D006353:Heart-Assist Devices / Q000009:adverse effects; D006801:Humans; D008955:Models, Cardiovascular; D011474:Prosthesis Design; D012212:Rheology