The angiotensin I converting enzyme gene as a susceptibility factor for dementia.
The frequency of a genetic susceptibility vascular factor, the deletion (D) allele of the angiotensin I converting enzyme gene (ACE), coding for a key enzyme of the renin angiotensin system, was characterized in two independent case--control studies. The results of the current study suggest that bearing at least one ACE D allele is a risk factor to develop dementia for subjects older than 74 years. This observation reinforces the hypothesis of a major implication of vascular risk factors in the occurrence of all types of dementia.
Richard
F
F
INSERM Unité 508, Institut Pasteur de Lille, France.
Fromentin-David
I
I
Ricolfi
F
F
Ducimetière
P
P
Di Menza
C
C
Amouyel
P
P
Helbecque
N
N
D000368:Aged; D000483:Alleles; D016022:Case-Control Studies; D003704:Dementia / Q000453:epidemiology* / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D012307:Risk Factors
D007703:Peptidyl-Dipeptidase A