Administration and clearance of amphotericin B during high-efficiency or high-efficiency/high-flux dialysis.
Administration and clearance of amphotericin B infused during high-efficiency or high-efficiency/high-flux dialysis were studied in two end-stage renal disease patients requiring systemic antimycotic treatment for fungal peritonitis. Amphotericin B concentrations were measured in the arterial and venous dialysis ports as well as in the ultrafiltrate. Amphotericin B is poorly dialyzable while administered during hemodialysis sessions with high-efficiency (CA 210) or high-efficiency/high-flux (CT 190 G) membranes. Amphotericin B infusion during hemodialysis was well tolerated and can be administered conveniently in an outpatient dialysis setting, avoiding prolonged hospitalization for parenteral antifungal therapy.
Gussak
H M
HM
Division of Nephrology, St. Louis University School of Medicine, St. Louis, MO 63110, USA.
Rahman
S
S
Bastani
B
B
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000666:Amphotericin B / Q000097:blood / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002175:Candida / Q000187:drug effects; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000628:therapy*; D008297:Male; D010538:Peritonitis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D006435:Renal Dialysis / Q000379:methods*
D000935:Antifungal Agents; D000666:Amphotericin B