title: Selenium status in an iodine deficient population of the West Ivory Coast.
abstract: Selenium is an essential trace element which is part of the active site of seleno-dependent glutathione peroxidase and type 1 deiodinase. Therefore, it plays a key role in thyroid hormone metabolism. The present work was undertaken in order to evaluate selenium status in two Ivory Coast populations: the first with high (Glanlé) and the second with low (Abidjan) prevalence of iodine deficiency. Selenium, glutathione peroxidase, glutathione reductase, glutathione and diglutathione were determined in blood and/or urine. In plasma and erythrocytes, selenium and glutathione peroxidase were dramatically low in Glanlé. Compared to Abidjan, selenium, glutathione peroxidase, vitamin E and riboflavin status were decreased whereas diglutathione was increased in Glanlé. The results clearly demonstrate a selenium deficiency and suggest an oxidant stress in Glanlé. Causes and consequences of this selenium deficiency and oxidant stress remain to be determined.
authors.affiliation: Department of Integral Biology, CHUG, Grenoble, France. Josiane.Arnaud@ujf-grenoble.fr
authors.forename: J
authors.initials: J
authors.lastname: Arnaud
authors.forename: D
authors.initials: D
authors.lastname: Malvy
authors.forename: M J
authors.initials: MJ
authors.lastname: Richard
authors.forename: H
authors.initials: H
authors.lastname: Faure
authors.forename: A
authors.initials: A
authors.lastname: Chaventré
mesh_terms: D000884:Anthropology, Cultural; D007560:Cote d'Ivoire; D005978:Glutathione / Q000097:blood / Q000652:urine; D005979:Glutathione Peroxidase / Q000097:blood / Q000652:urine; D005980:Glutathione Reductase / Q000097:blood / Q000652:urine; D006801:Humans; D007455:Iodine / Q000172:deficiency*; D012643:Selenium / Q000097:blood / Q000172:deficiency* / Q000652:urine
chemical_list: D007455:Iodine; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione; D012643:Selenium