Severe atherosclerotic changes, including aortic occlusion, associated with hyperhomocysteinaemia and antiphospholipid antibodies.
Three patients are described with severe systemic atherosclerosis, including aortic occlusion, in the presence of a spectrum of risk factors, including hypercholesterolaemia, hypertension, a positive family history of cardiovascular problems, and hyperhomocysteinaemia. In all three patients high levels of anticardiolipin antibodies were found. The possible pathogenic role of antiphospholipid antibodies in atherosclerosis in the context of hyperhomocysteinaemia in these patients is discussed.
Spronk
P E
PE
Department of Internal Medicine, Kennemer Gasthuis (EG), Haarlem, The Netherlands. pspronk@wish.net
Overbosch
E H
EH
Schut
N H
NH
D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis*; D001027:Aortography; D001161:Arteriosclerosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology; D002445:Celiac Artery / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000000981:diagnostic imaging / Q000276:immunology; D006973:Hypertension / Q000150:complications / Q000000981:diagnostic imaging / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012077:Renal Artery / Q000000981:diagnostic imaging; D012907:Smoking
D017153:Antibodies, Anticardiolipin