title: Sensation-seeking, life events and depression. The Cardiff Depression Study.
abstract: BACKGROUND
  The relationship between adversity and genetic risk factors in depression could be mediated by familial 'hazard prone' traits, as reflected in high levels of sensation-seeking.
  
  
  OBJECTIVE
  To examine whether high sensation-seeking scores are associated with more adverse life events resulting in depression.
  
  
  METHODS
  In a sib-pair design, 108 probands with depression and their siblings and 105 healthy control subjects and their siblings were compared for psychopathology, life events and scores on the Sensation-Seeking Questionnaire (SSQ).
  
  
  RESULTS
  The SSQ scores were correlated negatively with depression, were familial and were correlated positively with less severe events, but not the severe events typically associated with depressive onsets.
  
  
  CONCLUSIONS
  The SSQ measures a familial personality trait and depression is associated with lower scores. Although high sensation-seeking is associated with a higher rate of life events, these carry little threat.
authors.affiliation: Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, Denmark Hill, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Farmer
authors.forename: K
authors.initials: K
authors.lastname: Redman
authors.forename: T
authors.initials: T
authors.lastname: Harris
authors.forename: A
authors.initials: A
authors.lastname: Mahmood
authors.forename: S
authors.initials: S
authors.lastname: Sadler
authors.forename: P
authors.initials: P
authors.lastname: McGuffin
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000235:genetics* / Q000523:psychology*; D005260:Female; D006801:Humans; D008016:Life Change Events; D008297:Male; D008875:Middle Aged; D011594:Psychometrics; D012307:Risk Factors; D012309:Risk-Taking; D012737:Sex Factors