One-pot, catalytic, asymmetric synthesis of polypropionates.
[reaction: see text] The opening of methylketene dimer, followed by aldol reactions of the resulting enolate, provides a convenient access to syn,syn-dipropionate aldol adducts of a variety of aldehydes. These aldol adducts are useful precursors in the synthesis of complex polypropionates.
Calter
M A
MA
Department of Chemistry, University of Rochester, Rochester, New York 14627-0216, USA. calter@chem.rochester.edu
Guo
X
X
Liao
W
W
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D011108:Polymers / Q000138:chemical synthesis; D011422:Propionates / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D011108:Polymers; D011422:Propionates; C029658:propionic acid