Peritoneal implantation of macroencapsulated porcine pancreatic islets in diabetic rats ameliorates severe hyperglycemia and prevents retraction and simplification of hippocampal dendrites.
The hippocampus of rats with uncontrolled insulin-dependent diabetes undergoes retraction and simplification of apical dendrites of the CA3 pyramidal neurons and synaptic rearrangements within mossy fiber terminals that could alter hippocampal connectivity and function. The intraperitoneal implantation of hydrophilic agarose macrobeads containing porcine islets for 17 days in rats with streptozotocin-induced diabetes results in normalization of body weight gain, significant control of hyperglycemia and prevention of hippocampal dendritic remodeling, and therefore, provides an effective therapeutic option.
Magariños
A M
AM
Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, 10021, New York, NY, USA. magaria@rockvax.rockefeller.edu
Jain
K
K
Blount
E D
ED
Reagan
L
L
Smith
B H
BH
McEwen
B S
BS
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D002096:C-Peptide / Q000378:metabolism; D002214:Capsules / Q000494:pharmacology; D003712:Dendrites / Q000378:metabolism / Q000473:pathology*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D005934:Glucagon / Q000378:metabolism; D006085:Graft Survival / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology* / Q000503:physiopathology; D006943:Hyperglycemia / Q000150:complications / Q000503:physiopathology / Q000601:surgery*; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D016381:Islets of Langerhans Transplantation / Q000379:methods / Q000502:physiology*; D008297:Male; D009410:Nerve Degeneration / Q000209:etiology / Q000517:prevention & control / Q000601:surgery*; D010537:Peritoneum / Q000601:surgery; D017966:Pyramidal Cells / Q000378:metabolism / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013552:Swine; D016896:Treatment Outcome
D001786:Blood Glucose; D002096:C-Peptide; D002214:Capsules; D007328:Insulin; D005934:Glucagon