Novel HLA allele, HLA-B*4013, identified from a potential bone marrow recipient. Putative gene conversion events with donor sequence.
A new B40 allele was identified in a leukemic Caucasian patient. This allele, designated B*4013, differs in alpha 1 domain from B*4002 at six amino acidic positions: 67, 77, 80, 81, 82 and 83. Most of this substitutions could alter the antigen binding site of the HLA-B molecule. B*4013 may have originated by gene conversion or reciprocal recombination involving B*4002 as the recipient allele of sequence donated by B*4406. The new allele was serologically typed as a "blank" associated with the Bw4 epitope.
Blanco
P V
PV
Laboratorio de Inmunogenética, Hospital de Clínicas, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
Theile
G
G
Marcos
C
C
Capucchio
M
M
Lindel
N
N
Sala
L
L
Fainboim
L
L
Satz
M L
ML
D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D005260:Female; D005785:Gene Conversion / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics*; D059947:HLA-B40 Antigen; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000276:immunology / Q000628:therapy; D008297:Male; D008969:Molecular Sequence Data; D014019:Tissue Donors
D015235:HLA-B Antigens; C439540:HLA-B*40:13 antigen; D059947:HLA-B40 Antigen