title: Hemodynamics and gas exchange during carbon dioxide insufflation for totally endoscopic coronary artery bypass grafting.
abstract: BACKGROUND
  In addition to single-lung ventilation (SLV), positive-pressure CO2 insufflation is mandatory for totally endoscopic coronary artery bypass grafting. Studies on the effects of unilateral CO2 insufflation on hemodynamics produced controversial results, and bilateral insufflation has not been studied to our knowledge. The present study sought to investigate hemodynamics and gas exchange during unilateral and bilateral CO2 insufflation in patients who underwent totally endoscopic coronary artery bypass grafting.
  
  
  METHODS
  Eleven hemodynamic and gas exchange variables were monitored during 22 totally endoscopic coronary artery bypass grafting procedures with unilateral (n = 17) or bilateral (n = 5) CO2 insufflation at a pressure of 10 to 12 mm Hg. Data were obtained at baseline with double-lung ventilation, after institution of SLV, during insufflation, after cardiopulmonary bypass during SLV, and after return to double-lung ventilation.
  
  
  RESULTS
  Arterial oxygen tension decreased significantly during SLV, whereas the peak inspiratory pressure increased. In addition, central venous pressure and heart rate increased significantly during insufflation, but mean arterial pressure remained unchanged. Although the end-tidal CO2 pressure did not change, arterial carbon dioxide tension increased progressively to a maximum of 44.6 +/- 5.9 mm Hg during unilateral insufflation, and 55.7 +/- 14.6 mm Hg during bilateral insufflation (p < 0.05 versus baseline and between groups). Mixed venous oxygen saturation declined during SLV regardless of CO2 insufflation and recovered to baseline once double-lung ventilation was restarted. Left and right ventricular ejection fractions remained unaltered. No patient required inotropic or vasopressor support.
  
  
  CONCLUSIONS
  Carbon dioxide insufflation for totally endoscopic coronary artery bypass grafting with SLV had no adverse effects on hemodynamics. In contrast to a moderate increase of arterial carbon dioxide tension during unilateral insufflation, markedly elevated arterial carbon dioxide tension levels remain a cause of concern during bilateral insufflation.
authors.affiliation: Department of Anesthesiology, JW Goethe-University Hospital, Frankfurt, Germany. c.byhahn@em.uni-frankfurt.de
authors.forename: C
authors.initials: C
authors.lastname: Byhahn
authors.forename: S
authors.initials: S
authors.lastname: Mierdl
authors.forename: D
authors.initials: D
authors.lastname: Meininger
authors.forename: G
authors.initials: G
authors.lastname: Wimmer-Greinecker
authors.forename: G
authors.initials: G
authors.lastname: Matheis
authors.forename: K
authors.initials: K
authors.lastname: Westphal
mesh_terms: D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000008:administration & dosage* / Q000097:blood; D002496:Central Venous Pressure / Q000502:physiology; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007327:Insufflation; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011446:Prospective Studies; D011659:Pulmonary Gas Exchange / Q000502:physiology*; D013318:Stroke Volume / Q000502:physiology; D013906:Thoracoscopy; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen