Soybean resistant proteins interrupt an enterohepatic circulation of bile acids and suppress liver tumorigenesis induced by azoxymethane and dietary deoxycholate in rats.
We found that azoxymethane and dietary deoxycholate induced liver tumors in rats. The incidence and the development of the tumor were closely related to the enterohepatic circulation of bile acids. The feeding of a high-molecular-weight fraction of soy protein digest (HMF) suppressed the tumorigenesis, probably due to the inhibitory effect of soybean resistant protein on reabsorption of bile acids in the intestine.
Kanamoto
R
R
Department of Biological Resource Chemistry, Kyoto Prefectural University, Japan. kanamoto@kpu.ac.jp
Azuma
N
N
Miyamoto
T
T
Saeki
T
T
Tsuchihashi
Y
Y
Iwami
K
K
D000818:Animals; D001397:Azoxymethane / Q000037:antagonists & inhibitors* / Q000633:toxicity; D001647:Bile Acids and Salts / Q000378:metabolism*; D002273:Carcinogens / Q000037:antagonists & inhibitors* / Q000633:toxicity; D002364:Caseins / Q000378:metabolism; D003840:Deoxycholic Acid / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004032:Diet; D004764:Enterohepatic Circulation / Q000187:drug effects*; D007082:Ileum / Q000502:physiology; D007408:Intestinal Absorption / Q000187:drug effects; D007583:Jejunum / Q000502:physiology; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008970:Molecular Weight; D051381:Rats; D011916:Rats, Inbred F344; D030262:Soybean Proteins / Q000494:pharmacology*
D001647:Bile Acids and Salts; D002273:Carcinogens; D002364:Caseins; D030262:Soybean Proteins; D003840:Deoxycholic Acid; D001397:Azoxymethane