Mouse models for human familial adenomatous polyposis.
Colorectal cancer (CRC) is the second most frequent type of cancer in the Western hemisphere. In the United States alone, it is estimated that 150 000 new cases are detected every year and more than 65 000 patients die from complications associated with this cancer. Identification of genes implicated in the initiation and progression of colorectal cancer in humans has prompted the generation of mouse models for this cancer. We will provide a brief overview of these mouse models for CRC and what they have contributed to our understanding of the events involved in the initiation and progression of this cancer.
Kucherlapati
R
R
Department of Molecular Genetics, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA. kucherla@aecom.yu.edu
Lin
D P
DP
Edelmann
W
W
D011125:Adenomatous Polyposis Coli / Q000235:genetics* / Q000473:pathology; D000818:Animals; D015179:Colorectal Neoplasms / Q000235:genetics; D004195:Disease Models, Animal; D018450:Disease Progression; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains