VAPSE-based analysis: a two-phased candidate gene approach for elucidating genetic predisposition to complex disorders.
The extraordinary success of linkage analysis in diseases with Mendelian inheritance has not extended readily to the genetics of common complex diseases. VAPSE-based analysis is a type of candidate gene approach that represents an alternative strategy by which genetic mechanisms can be defined despite the presence of substantial genetic heterogeneity. Recent advances in mutation screening and statistical methodology have enhanced substantially the efficiency and power of this approach. The "bread and butter" of VAPSE-based analysis is genotype-to-phenotype searches in large populations with computerized medical records.
Weinshenker
B G
BG
Department of Neurology, Mayo Clinic/Mayo Foundation, Rochester, MN, USA.
Sommer
S
S
D000544:Alzheimer Disease / Q000235:genetics; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics; D004812:Epidemiologic Methods; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D018740:Genetic Heterogeneity; D005821:Genetic Techniques; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D016347:Medical Records Systems, Computerized; D010641:Phenotype; D017422:Sequence Analysis, DNA; D013223:Statistics as Topic; D019851:Thrombophilia / Q000235:genetics