The Cell Physiology of Biphasic Insulin Secretion.
Glucose-stimulated insulin secretion consists of a transient first phase followed by a sustained second phase. Diabetes (type II) is associated with abnormalities in this release pattern. Here we review the evidence that biphasic insulin secretion reflects exocytosis of two functional subsets of secretory granules and the implications for diabetes.
Rorsman
Patrik
P
Department of Physiological Sciences, Division of Molecular and Cellular Physiology, Lund University, Sölvegatan 19, S-223 62 Lund, Sweden.
Eliasson
Lena
L
Renström
Erik
E
Gromada
Jesper
J
Barg
Sebastian
S
Göpel
Sven
S