title: Myocardial perfusion and angiographic correlations in patients with ST-segment elevation during dobutamine stress perfusion imaging.
abstract: BACKGROUND
  There is scanty information on the angiographic and myocardial perfusion correlates of dobutamine-induced ST-segment elevation.
  
  
  RESULTS
  We studied 39 patients who exhibited ST-segment elevation during dobutamine perfusion tomography and had recent coronary angiography performed (ie, within 3 months of the dobutamine study). Baseline characteristics, extent of coronary artery disease, relationship of Q waves to ST-segment elevation, ischemic burden, and angiographic findings were assessed. Twenty-nine patients (74%) had prior myocardial infarction, and 77% had abnormal Q waves at baseline. Ninety-three percent of patients had abnormal perfusion imaging. Eighty percent of patients had multivessel coronary artery disease. The left ventricular ejection fraction by contrast ventriculography was 35% +/- 7% (mean +/- SD), the perfusion defect size was 32% +/- 15%, and 73% of patients had some degree of myocardial ischemia. A predominance of ischemia (>50% reversibility) occurred in 38% of patients with Q waves and in 70% of those without Q waves. There was also good agreement between the site of ST-segment elevation and the site of ischemia by perfusion imaging (79%) and between the site of ST-segment elevation and the location of the vessel with significant coronary stenosis (95%).
  
  
  CONCLUSIONS
  Patients with dobutamine-induced ST-segment elevation have a depressed left ventricular ejection fraction, a high frequency of multivessel disease, and markedly abnormal myocardial perfusion tomography. In patients with ST-segment elevation and abnormal Q waves, substantial scarring and superimposed ischemia coexist, whereas in patients without Q waves, ST-segment elevation usually denotes severe ischemia.
authors.affiliation: Section of Cardiology, Baylor College of Medicine, and The Methodist Hospital, Houston, TX 77030, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Lee
authors.forename: Z X
authors.initials: ZX
authors.lastname: He
authors.forename: H
authors.initials: H
authors.lastname: Dakik
authors.forename: M S
authors.initials: MS
authors.lastname: Verani
mesh_terms: D000318:Adrenergic beta-Agonists; D000368:Aged; D000792:Angiography; D015331:Cohort Studies; D003327:Coronary Disease / Q000175:diagnosis; D004280:Dobutamine; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging; D010477:Perfusion; D012189:Retrospective Studies; D013318:Stroke Volume / Q000187:drug effects; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000318:Adrenergic beta-Agonists; D004280:Dobutamine