[Genetic analyses of essential hypertension].
Recent genetic studies using nonparametric linkage analyses have suggested that several chromosomal regions linked with hypertension. On the other hand, statistical estimation implied that linkage analyses did not have enough power to identify hypertension-susceptible genes that seemed to have weaker effects on blood pressure than expected previously. Although association analyses using single-nucleotide polymorphisms have been introduced with enthusiasm, it is necessary to solve several questions before we can apply this strategy to identify hypertension-susceptible genes. Not genotyping but phenotyping will become more and more important in the genetic studies of hypertension.
Nabika
T
T
Department of Laboratory Medicine, Shimane Medical University.
D000818:Animals; D002874:Chromosome Mapping; D004195:Disease Models, Animal; D008040:Genetic Linkage; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D015810:Linkage Disequilibrium; D010641:Phenotype; D020641:Polymorphism, Single Nucleotide; D051381:Rats; D011918:Rats, Inbred SHR