Treatment of migraine in Canada with naratriptan: a cost-effectiveness analysis.
OBJECTIVE
To evaluate the cost-effectiveness of naratriptan for the treatment of migraine in Canada.


BACKGROUND
The substantial disability brought on by migraine, coupled with the high prevalence of this disorder, leads to substantial costs. Naratriptan is a newly developed triptan shown to be effective in the treatment of migraine.


METHODS
Monte Carlo modeling techniques were used to simulate the experience of Canadian migraineurs over the course of 1 year. Data from a multinational study comparing oral naratriptan 2.5 mg to customary therapies were used in the cost-effectiveness analysis.


RESULTS
Naratriptan leads to an annual reduction in symptom duration of 225 hours compared to customary therapy not including other triptans. Reductions in lost productivity yield savings of Can $390 (1998 Canadian dollars) relative to customary therapy, which exceed the increase in drug costs resulting in overall savings of Can $109 per year.


CONCLUSIONS
The use of naratriptan in the treatment of migraine is an economically attractive option, leading to savings in overall costs. Increases in drug costs seem acceptable in light of reductions in symptom duration.
Caro
J J
JJ
Caro Research, Boston, Mass; Caro Research, Montreal, Quebec, Canada.
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Caro
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D002170:Canada; D003362:Cost-Benefit Analysis; D006801:Humans; D007211:Indoles / Q000191:economics* / Q000627:therapeutic use*; D008881:Migraine Disorders / Q000188:drug therapy*; D010880:Piperidines / Q000191:economics* / Q000627:therapeutic use*; D017366:Serotonin Receptor Agonists / Q000191:economics* / Q000627:therapeutic use*; D014363:Tryptamines; D014662:Vasoconstrictor Agents / Q000191:economics* / Q000627:therapeutic use*
D007211:Indoles; D010880:Piperidines; D017366:Serotonin Receptor Agonists; D014363:Tryptamines; D014662:Vasoconstrictor Agents; C106783:naratriptan