Differential development of Ca2+ dynamics in presynaptic terminal and postsynaptic neuron of the rat auditory synapse.
Postnatal development of Ca2+ influx and Ca2+ clearance capacity were investigated in the synapse of medial nucleus of the trapezoid body (MNTB) of rat with fura-2 fluorimetry. In contrast to the presynaptic terminal, Ca2+ dynamics does not basically change in the postsynaptic principal neuron developmentally. This differential development of Ca2+ dynamics between pre- and postsynaptic neurons might be crucial for the organized formation and functional maturation of this synapse.
Chuhma
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N
Department of Physiology, Faculty of Medicine, Kyoto University, 606-8501, Kyoto, Japan.
Ohmori
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H
D000818:Animals; D000831:Animals, Newborn; D001306:Auditory Pathways / Q000254:growth & development*; D001933:Brain Stem / Q000254:growth & development; D020013:Calcium Signaling / Q000502:physiology*; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D017729:Presynaptic Terminals / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000502:physiology*