Inflammatory bowel disease: Are there gender differences in the genetics of signal transduction? A preliminary study of cytosolic low molecular weight protein tyrosine phosphatase.
The phenotype of cytosolic Low Molecular Weight Protein Tyrosine Phosphatase (cLMWPTP or ACP1), an enzyme involved in signal transduction of insulin, PDGF and T-cell receptors, has been determined in 71 patients with Crohn's Disease (CD: 37 males and 34 females), 49 patients with Ulcerative Colitis (UC: 27 males and 22 females) and 358 consecutive newborns (194 males and 164 females). cLMWPTP phenotypes showing a high concentration of F isoforms are associated with CD in females and with UC in males. Since PTPases counteract the effects of protein tyrosines kinases, a high concentration of F isoform of cLMWPTP may influence the mucosal response to pathogenic factors, increasing susceptibility to CD in females and to UC in males.
Bottini
N
N
Division of Allergology and Clinical Immunology, University of Rome Tor Vergata School of Medicine, Rome, Italy.
Gloria-Bottini
F
F
Lucarini
N
N
Ronchetti
P G
PG
Fontana
L
L
D003093:Colitis, Ulcerative / Q000201:enzymology / Q000235:genetics; D003424:Crohn Disease / Q000201:enzymology / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D018392:Genomic Imprinting; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D015212:Inflammatory Bowel Diseases / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D010641:Phenotype; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational / Q000235:genetics; D017027:Protein Tyrosine Phosphatases / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor / Q000502:physiology; D012384:Rome / Q000453:epidemiology; D012727:Sex Characteristics; D015398:Signal Transduction / Q000235:genetics*
D007527:Isoenzymes; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor; C490429:ACP1 protein, human; D017027:Protein Tyrosine Phosphatases