Treatment of patients with refractory giardiasis.
Giardia lamblia is one of the most common parasitic infections. Although standard treatments are usually curative, some immunocompromised patients, including patients with acquired immunodeficiency syndrome as well as healthy patients, have giardiasis that is refractory to recommended regimens. We report our experience with 6 patients with giardiasis, for whom therapy with a combination of quinacrine and metronidazole resulted in cures for 5 of the 6 patients.
Nash
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Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.
Ohl
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Thomas
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Subramanian
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Keiser
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Moore
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D000328:Adult; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004351:Drug Resistance; D004359:Drug Therapy, Combination; D005260:Female; D016829:Giardia lamblia / Q000187:drug effects; D005873:Giardiasis / Q000188:drug therapy* / Q000469:parasitology; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D011796:Quinacrine / Q000627:therapeutic use*
D000981:Antiprotozoal Agents; D008795:Metronidazole; D011796:Quinacrine