Ras and Rho protein induction of motility and invasion in T47D breast adenocarcinoma cells.
There has been much interest in how Ras and Rho proteins affect cell migration and invasion. Studies of the molecular mechanisms and signaling pathways that are involved will be aided by the development and use of relevant model systems and simple in vitro assays. While a complete understanding of metastasis will ultimately need to employ in vivo studies, the migration and invasion assays presented here are good initial assessments of events that are relevant to the metastatic cascade.
Keely
P J
PJ
Department of Pharmacology, University of Wisconsin, Madison, Wisconsin 53706, USA.
D000230:Adenocarcinoma; D001943:Breast Neoplasms; D002465:Cell Movement / Q000235:genetics*; D002471:Cell Transformation, Neoplastic; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009362:Neoplasm Metastasis / Q000235:genetics; D014162:Transfection; D014407:Tumor Cells, Cultured; D018631:ras Proteins / Q000235:genetics* / Q000378:metabolism; D020741:rho GTP-Binding Proteins / Q000235:genetics* / Q000378:metabolism
D018631:ras Proteins; D020741:rho GTP-Binding Proteins