title: [Proteolytic system in lungs upon inhalation exposure to low doses of lead salts].
abstract: Changes in proteinase--antiproteinase activities in lungs as a result of short-term (for 1 week) inhalation of rats with 0.01% (CH3COO)2 Pb have wholly compensative patterns, but it have been found increased cathepsine B activity as a negative prognostic factor. Chronic (for 2 month) toxicant inhalation caused considerable activation of both trypsine and cathepsine B under decreasing alpha 1-antitrypsine and alpha 2-macroglobuline activities. Cathepsine L activity was not affected. Disorders in the proteolysis system were evaluated as desadaptation situation in lung tissue under chronic toxic influence.
authors.affiliation: Ukrainian State Research Institute of Medical and Social Problems of Physical Disability, Dnipropetrovsk.
authors.forename: E A
authors.initials: EA
authors.lastname: Likholat
authors.forename: T V
authors.initials: TV
authors.lastname: Anan'eva
authors.forename: S V
authors.initials: SV
authors.lastname: Antoniuk
authors.forename: N B
authors.initials: NB
authors.lastname: Lutova
mesh_terms: D000818:Animals; D002401:Cathepsin B / Q000378:metabolism; D056668:Cathepsin L; D002403:Cathepsins / Q000378:metabolism; D003546:Cysteine Endopeptidases; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D006868:Hydrolysis; D019570:Inhalation Exposure; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051381:Rats; D012492:Salts; D014357:Trypsin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
chemical_list: D012492:Salts; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D007854:Lead; D002403:Cathepsins; D014357:Trypsin; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D056668:Cathepsin L; C534280:Ctsl protein, rat