title: Dr operon-associated invasiveness of Escherichia coli from pregnant patients with pyelonephritis.
abstract: We used a gentamicin protection assay to assess the ability of gestational pyelonephritis isolates of Escherichia coli to invade HeLa cells. The ability to enter HeLa cells was strongly associated with the presence of Dr operons coding for Dr adhesins. In contrast, the nonivasive isolates predominantly expressed papG, coding for P fimbriae.
authors.affiliation: Departments of Obstetrics and Gynecology, University of Texas Medical Branch, Galveston, Texas 77555, USA. pgoluszk@utmb.edu
authors.forename: P
authors.initials: P
authors.lastname: Goluszko
authors.forename: D
authors.initials: D
authors.lastname: Niesel
authors.forename: B
authors.initials: B
authors.lastname: Nowicki
authors.forename: R
authors.initials: R
authors.lastname: Selvarangan
authors.forename: S
authors.initials: S
authors.lastname: Nowicki
authors.forename: A
authors.initials: A
authors.lastname: Hart
authors.forename: E
authors.initials: E
authors.lastname: Pawelczyk
authors.forename: M
authors.initials: M
authors.lastname: Das
authors.forename: P
authors.initials: P
authors.lastname: Urvil
authors.forename: R
authors.initials: R
authors.lastname: Hasan
mesh_terms: D018829:Adhesins, Bacterial / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D018958:CD55 Antigens / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism / Q000472:pathogenicity*; D005260:Female; D010861:Fimbriae, Bacterial / Q000235:genetics / Q000378:metabolism; D006367:HeLa Cells; D006801:Humans; D009876:Operon; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000382:microbiology*; D011704:Pyelonephritis / Q000382:microbiology*
chemical_list: D018829:Adhesins, Bacterial; D018958:CD55 Antigens