[Ovarian function in androgenized rats in puberty].
In experiment on rats injected with aromatase inhibitor or with dihydrotestosterone (DHT) it has been revealed that increase of androgens level in blood stimulates ovarial folliculogenesis on its early stages. DHT as compared with testosterone accelerates small follicles growth more effectively. Androgens, particularly DHT (7 mkg/100 g), suppress preovarial follicules maturing and turn them into atretic ones. Suppressing of ovarial functional activity delays or blockages the first ovulation during rats puberty.
Litvinova
L B
LB
Ukrainian Research Institute of Endocrine Diseases Pharmacotherapy.
D000728:Androgens / Q000494:pharmacology; D000818:Animals; D047072:Aromatase Inhibitors; D013196:Dihydrotestosterone / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology; D017588:Hyperandrogenism / Q000503:physiopathology*; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012741:Sexual Maturation; D013739:Testosterone / Q000494:pharmacology
D000728:Androgens; D047072:Aromatase Inhibitors; D012739:Gonadal Steroid Hormones; D013196:Dihydrotestosterone; D013739:Testosterone