title: Surgical treatment of recurrent pleomorphic adenoma of the parotid gland: a clinical analysis of 52 patients.
abstract: BACKGROUND
  Surgical management of recurrent pleomorphic adenoma of the parotid gland has a considerable risk of facial nerve injury and a high re-recurrence rate. To obtain more insight into this issue we evaluated our experiences.
  
  
  METHODS
  Medical records and histologic material of all these patients (31 women and 21 men), who had been treated from 1976-1995 were reviewed. Median interval between initial treatment and commencement of recurrences was 3 (0.8-18) years. Last surgery consisted of parotidectomy in 48 patients (92%), including 19 (40%) total procedures and wide local excision with involved skin in four patients.
  
  
  RESULTS
  At a median follow-up of 9 years, eight patients (8/52; 15%) had re-recurrences develop, including 4 of 21 patients (19%) after a previous parotidectomy (group I) and 4 of 31 patients (13%) without prior parotidectomy (group II). The chance of re-recurrence in a group of patients with a minimal follow-up of 10 years after salvage surgery was 17% (4 of 24). The risk of a new relapse was, respectively, 4% and 8% at 1 and 5 years after treatment of recurrent disease. Acceptable N.VII function was preserved in 45 of the 49 (92%) nerves at risk. The risk of N.VII injuy was higher and more serious in group I (29% vs 10% in group II). The function of four of the five (80%) reconstructed zygomaticotemporal branches of the N.VII was adequate.
  
  
  CONCLUSIONS
  Surgical treatment of recurrent pleomorphic adenoma of the parotid gland, usually consisting of a parotidectomy with wide extent and eventually facial nerve reconstruction, demonstrates favorable results with acceptable morbidity. The risk of new relapse and N.VII injury was higher after previous parotidectomy.
authors.affiliation: Department of Surgical Oncology/Head and Neck Surgery, University Hospital, Groningen, P.O. Box 30.001, 9700RB The Netherlands.
authors.forename: A S
authors.initials: AS
authors.lastname: Glas
authors.forename: A
authors.initials: A
authors.lastname: Vermey
authors.forename: H
authors.initials: H
authors.lastname: Hollema
authors.forename: P H
authors.initials: PH
authors.lastname: Robinson
authors.forename: J L
authors.initials: JL
authors.lastname: Roodenburg
authors.forename: R E
authors.initials: RE
authors.lastname: Nap
authors.forename: J T
authors.initials: JT
authors.lastname: Plukker
mesh_terms: D008949:Adenoma, Pleomorphic / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005154:Facial Nerve; D020220:Facial Nerve Injuries / Q000209:etiology; D005260:Female; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000601:surgery*; D010307:Parotid Neoplasms / Q000601:surgery*; D012189:Retrospective Studies; D016896:Treatment Outcome