title: Patient-prosthesis mismatch can be predicted at the time of operation.
abstract: BACKGROUND
  Patient-prosthesis mismatch is a frequent cause of high postoperative gradients in normally functioning prostheses. The objective of this study was to determine whether mismatch can be predicted at the time of operation.
  
  
  METHODS
  Indices used to predict mismatch were valve size, indexed internal geometric area, and projected indexed effective orifice area (EOA) calculated at the time of operation, and results were compared with indexed EOA and mean gradients measured by Doppler echocardiography after operation in 396 patients.
  
  
  RESULTS
  The sensitivity and specificity of these indices to detect mismatch, defined as a postoperative indexed EOA of 0.85 cm2/m2 or less, were respectively: 35% and 84% for valve size, 46% and 85% for indexed internal geometric area, and 73% and 80% for projected indexed EOA. Projected indexed EOA also correlated best with resting (r = 0.67) and exercise (r = 0.77) postoperative gradients.
  
  
  CONCLUSIONS
  The projected indexed EOA calculated at the time of operation accurately predicts mismatch as well as resting and exercise postoperative gradients, whereas valve size and indexed internal geometric area cannot be used for this purpose.
authors.affiliation: Quebec Heart Institute, Laval Hospital, Laval University, Sainte-Foy, Canada. philippe.pibarot@med.ulaval.ca
authors.forename: P
authors.initials: P
authors.lastname: Pibarot
authors.forename: J G
authors.initials: JG
authors.lastname: Dumesnil
authors.forename: P C
authors.initials: PC
authors.lastname: Cartier
authors.forename: J
authors.initials: J
authors.lastname: Métras
authors.forename: M D
authors.initials: MD
authors.lastname: Lemieux
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000601:surgery* / Q000637:transplantation; D001705:Bioprosthesis; D015150:Echocardiography, Doppler; D005260:Female; D006349:Heart Valve Diseases / Q000000981:diagnostic imaging / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D011183:Postoperative Complications / Q000000981:diagnostic imaging / Q000517:prevention & control; D011237:Predictive Value of Tests; D011474:Prosthesis Design; D017755:Prosthesis Fitting; D011664:Pulmonary Valve / Q000637:transplantation; D015607:Stents; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous