Vincristine-induced allodynia in the rat.
The aims of this study were two-fold: first, to simplify the method for creating a recently described neuropathic pain model in the rat, and second, to evaluate the effects of a number of drugs with analgesic or antihyperalgesic properties, in this model. Continuous intravenous vincristine infusion (1-100 microg kg(-1) day (-1)) for 14 days resulted in a dose dependent tactile allodynia (as measured by von Frey filaments) by 7 days at doses between 30 - 100 microg kg(-1) day (-1), with a hindlimb motor deficit observed at doses greater than 50 microg kg(-1) day (-1). No thermal hyperalgesia was observed. Systemic morphine, lidocaine, mexiletine and pregabalin (given intraperitoneally) produced significant reduction of the allodynia, while tetrodotoxin was without effect. Continuous intravenous infusion of vincristine in rats thus provides a reliable model of chemotherapy induced neuropathy which may be used in defining the mechanism and pharmacology of this clinically relevant condition.
Nozaki-Taguchi
Natsuko
N
Anesthesiology Research Laboratory, Department of Anesthesiology 0818, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0818, USA.
Chaplan
Sandra R
SR
Higuera
Emiliano S
ES
Ajakwe
Reginald C
RC
Yaksh
Tony L
TL
D000085:Acetates / Q000494:pharmacology; D000588:Amines; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D000077206:Gabapentin; D006358:Hot Temperature; D015640:Ion Channel Gating / Q000187:drug effects; D008297:Male; D010146:Pain / Q000139:chemically induced*; D010147:Pain Measurement / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013779:Tetrodotoxin / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000700:Analgesics; D000972:Antineoplastic Agents, Phytogenic; D003509:Cyclohexanecarboxylic Acids; D018691:Excitatory Amino Acid Antagonists; D013779:Tetrodotoxin; D005680:gamma-Aminobutyric Acid; D014750:Vincristine; D000077206:Gabapentin