title: Parathyroidectomy in chronic renal failure: short- and long-term results on parathyroid function, blood pressure and anemia.
abstract: To evaluate the long-term results of parathyroidectomy (PTX) on parathyroid function, blood pressure and anemia, data of 45 patients with secondary Hyperparathyroidism in dialysis who had undergone PTX were collected retrospectively from 8 different dialysis units. The patients, 25 M and 20 F, mean age 56 +/- 11 years, who were followed up for an average period of 3.3 +/- 2.3 years, were divided into four groups according to the surgical procedure: 19 patients had had a subtotal PTX; 10 patients had undergone total PTX with autotransplantation (AT); 10 patients had had total PTX without AT, and 6 patients had undergone partial PTX. Taking a reduction in intact PTH > 50% as sign of successful PTX, only 5 patients did not attain this result. Considering values of PTH between 20 and 200 pg/ml at the mid-term observation (1-2 years) as the optimal result, values under 20 pg/ml as an expression of permanent hypoparathyroidism, and those above 200 pg/ml as indicating persistent/recurrent hyperparathyroidism, 65.5% of patients operated with subtotal PTX and total PTX + AT had a therapeutic success, versus 31.2% of patients in the other two groups, due to excess permanent hypoparathyroidism and persistent/recurrent hyperparathyroidism; 20 of 45 patients with preoperative hypertension experienced a statistically and clinically significant decrease in blood pressure levels. An increase in serum hemoglobin was also observed, despite a reduction of administered erythropoietin. In conclusion, the results of PTX obtained from this multicenter study are comparable to those reported by single leading centers. Recommended surgical procedures are subtotal PTX and total PTX with AT. The fall in blood pressure in hypertensive patients is clinically significant, and improvement in anemia is also observed with a reduction in erythropoietin dosage.
authors.affiliation: La Sapienza University, Rome, Italy. coen.gf@flashnet.it
authors.forename: G
authors.initials: G
authors.lastname: Coen
authors.forename: S
authors.initials: S
authors.lastname: Calabria
authors.forename: G
authors.initials: G
authors.lastname: Bellinghieri
authors.forename: F
authors.initials: F
authors.lastname: Pecchini
authors.forename: F
authors.initials: F
authors.lastname: Conte
authors.forename: M G
authors.initials: MG
authors.lastname: Chiappini
authors.forename: M
authors.initials: M
authors.lastname: Ferrannini
authors.forename: C
authors.initials: C
authors.lastname: Lagona
authors.forename: A
authors.initials: A
authors.lastname: Mallamace
authors.forename: M
authors.initials: M
authors.lastname: Manni
authors.forename: M
authors.initials: M
authors.lastname: DiLuca
authors.forename: D
authors.initials: D
authors.lastname: Sardella
authors.forename: F
authors.initials: F
authors.lastname: Taggi
mesh_terms: D000368:Aged; D000740:Anemia / Q000097:blood / Q000517:prevention & control*; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010280:Parathyroid Glands / Q000503:physiopathology*; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D006435:Renal Dialysis / Q000009:adverse effects*; D012189:Retrospective Studies
chemical_list: D006454:Hemoglobins; D010281:Parathyroid Hormone