title: Treatment of chronic anal fissure with topical glyceryl trinitrate: a double-blind, placebo-controlled trial.
abstract: BACKGROUND
  Topical glyceryl trinitrate (GTN) may produce healing of anal fissure by decreasing the high resting anal sphincter pressure in these patients. The present study assessed the efficacy of GTN in chronic anal fissure in a double-blind placebo-controlled trial.
  
  
  METHODS
  Patients with chronic anal fissure (for more than 8 weeks) underwent measurement of maximum anal resting pressure (MARP) before and 12 minutes after application of either 0.2% GTN or placebo ointment in a randomized manner. They then received twice-daily local application of their respective ointment for 6 weeks. Symptoms and healing of fissure were assessed; patients were evaluated at 3 months for evidence of relapse.
  
  
  RESULTS
  19 adult patients (12 men) were studied; 10 received GTN and 9 placebo. Mean (SD) MARP decreased from 131.0 (32.3) cm H2O to 93.5 (28.4) cm H2O (p<0.05) with GTN and from 150.5 (36.9) cm H2O to 142.8 (35.0) cm H2O (p=ns) with placebo. Fissure healed in 7 of 10 patients treated with GTN and 2 of 9 patients treated with placebo (p<0.05). There was no relapse of fissure in either group.
  
  
  CONCLUSIONS
  Local application of GTN was effective in healing chronic anal fissure.
authors.affiliation: Department of Gastroenterology, Institute of Post-Graduate Medical Education and Research, Kolkata. schaudhuri@apexmail.com
authors.forename: S
authors.initials: S
authors.lastname: Chaudhuri
authors.forename: A K
authors.initials: AK
authors.lastname: Pal
authors.forename: A
authors.initials: A
authors.lastname: Acharya
authors.forename: A
authors.initials: A
authors.lastname: Dey
authors.forename: A
authors.initials: A
authors.lastname: Chowdhury
authors.forename: A
authors.initials: A
authors.lastname: Santra
authors.forename: G K
authors.initials: GK
authors.lastname: Dhali
authors.forename: S G
authors.initials: SG
authors.lastname: Maity
authors.forename: P K
authors.initials: PK
authors.lastname: Banerjee
mesh_terms: D000287:Administration, Topical; D000328:Adult; D016009:Chi-Square Distribution; D002908:Chronic Disease; D004311:Double-Blind Method; D005260:Female; D005401:Fissure in Ano / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008365:Manometry; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use*; D016896:Treatment Outcome; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014665:Vasodilator Agents; D005996:Nitroglycerin