Advanced glycation and lipoxidation end products: reactive carbonyl compounds-related uraemic toxicity.
Most studies on uraemic toxins have focused on disorders of enzymatic biochemistry. Recent studies to elucidate the pathogenesis of dialysis-related amyloidosis have provided new insights in progressive, irreversible protein modifications resulting from non-enzymatic biochemistry in uraemia. This paper focuses on two types of irreversible alterations of proteins: advanced glycation and lipoxidation. We investigate the causal role of various reactive carbonyl compounds (RCOs) accumulating in the serum, speculate on its clinical consequences, and discuss the therapeutic perspectives.
Miyata
T
T
Institute of Medical Sciences and Department of Medicine, Tokai University School of Medicine, Isehara, Kanagawa 259-11, Japan.
Saito
A
A
Kurokawa
K
K
van Ypersele de Strihou
C
C
D000818:Animals; D017127:Glycation End Products, Advanced / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D015227:Lipid Peroxidation; D006435:Renal Dialysis / Q000009:adverse effects; D014511:Uremia / Q000209:etiology / Q000378:metabolism* / Q000628:therapy
D017127:Glycation End Products, Advanced