[Prevention of thromboembolism in spinal fractures with spinal cord injuries. Standard heparin versus low-molecular-weight heparin in acute paraplegia].
In a prospective, randomized, open study, the therapeutic efficacy of a long-term prophylaxis with standard heparin (SH) was compared with that of low-molecular-weight heparin (LMWH) Dalteparin in 166 patients who had spinal fractures with spinal cord injury. 86 patients were treated with SH 2 x 7500 U s.c. and 80 patients were treated with LMWH 1 x 5000 anti-Xa U s.c. once daily. The screening was implemented by daily bedside-examination. In case of clinical thromboembolism-symptoms patients had confirmatory venography or lung scans. In the SH-group 12 (14.0%) patients had deep vein thrombosis and in the LMWH-group 6 (7.5%). Pulmonary embolism was detected two times in the SH-group (2.33%) and only one time in the LMWH-group (1.25%). A significant difference could not be shown, but is descriptive evident.
Lohmann
U
U
Abteilung für Neurotraumatologie und Rückenmarkverletzte, BG-Kliniken Bergmannsheil, Universitätsklinik Bochum.
Gläser
E
E
Braun
B E
BE
Bötel
U
U
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D006495:Heparin, Low-Molecular-Weight / Q000008:administration & dosage*; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000150:complications / Q000188:drug therapy*; D011446:Prospective Studies; D013119:Spinal Cord Injuries / Q000150:complications / Q000188:drug therapy*; D016103:Spinal Fractures / Q000150:complications / Q000188:drug therapy*; D013923:Thromboembolism / Q000209:etiology / Q000517:prevention & control*; D016896:Treatment Outcome
D006495:Heparin, Low-Molecular-Weight; D006493:Heparin