title: Defibrillation energy requirements and electrical heterogeneity during total body hypothermia.
abstract: OBJECTIVE
  Determine the effects of hypothermia on defibrillation energy requirements and cardiac electrophysiology.
  
  
  METHODS
  Prospective randomized acute intervention trial.
  
  
  METHODS
  Medical center animal laboratory.
  
  
  METHODS
  Fifteen domestic farm swine.
  
  
  METHODS
  Swine were randomized to a hypothermia group (n = 8) or a control group (n = 7). All animals were instrumented with a transvenous defibrillation system connected to a defibrillator that delivers a biphasic-truncated waveform. Values for defibrillation energy requirements were measured at baseline (normothermia, 38-40 degrees C) and during treatment with total body hypothermia (30 degrees C) or no temperature change (sham). Hypothermia was induced by circulating ice-water through anterior and posterior surgical thermal blankets.
  
  
  RESULTS
  Defibrillation energy requirement values at 20%, 50%, and 80% were determined by using an up/down method. In the hypothermia group, defibrillation energy requirement values at baseline did not significantly change during hypothermia (defibrillation energy requirements 50% = 14 +/- 2 J vs. 15 +/- 2 J, respectively). Similarly, the defibrillation energy requirement values in the control group did not change from baseline to sham phase (defibrillation energy requirements 50% = 12 +/- 1 J vs. 13 +/- 1 J, respectively). Hypothermia profoundly affected cardiac electrophysiology, decreasing ventricular fibrillation threshold by 72%, conduction velocity by 25% (p < .01), and tissue excitability, while it prolonged ventricular repolarization and refractoriness by 7.5% to 15%, respectively (p < .05).
  
  
  CONCLUSIONS
  Total body cooling to 30 degrees C was highly arrhythmogenic, although this unstable electrophysiological state did not alter ventricular defibrillation energy requirements. These data suggest that hypothermia may be used to slow metabolic processes without concern over the ability to successfully defibrillate and treat hypothermia-induced arrhythmias.
authors.affiliation: University of Georgia College of Pharmacy, Augusta VA Medical Center, and Medical College of Georgia School of Medicine, Augusta, GA, USA.
authors.forename: M R
authors.initials: MR
authors.lastname: Ujhelyi
authors.forename: J J
authors.initials: JJ
authors.lastname: Sims
authors.forename: S A
authors.initials: SA
authors.lastname: Dubin
authors.forename: J
authors.initials: J
authors.lastname: Vender
authors.forename: A W
authors.initials: AW
authors.lastname: Miller
mesh_terms: D000818:Animals; D004554:Electric Countershock; D004594:Electrophysiology; D004734:Energy Metabolism; D007035:Hypothermia / Q000378:metabolism*; D013552:Swine; D014693:Ventricular Fibrillation / Q000628:therapy*