Model systems for flavoenzyme activity. Control of flavin recognition via specific electrostatic interactions.
[structure: see text] A model system has been used to study the interactions of dipole-containing aromatic systems with oxidized and reduced flavin. Ab initio computational and experimental studies show that dipole orientation within the host is a critical determinant for recognition and redox behavior of the flavin guest.
Goodman
A J
AJ
Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
Breinlinger
E C
EC
McIntosh
C M
CM
Grimaldi
L N
LN
Rotello
V M
VM
D019281:Dimerization; D005415:Flavins / Q000378:metabolism*; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D011485:Protein Binding; D055672:Static Electricity; D013816:Thermodynamics
D005415:Flavins; D010088:Oxidoreductases