Convergent functional genomics: application to bipolar disorder.
The recent development of microarray technologies has made possible the simultaneous measurement of mRNA levels for thousands of genes and a new genomic method termed gene expression profiling. The application of this approach to animal models or post-mortem tissue provides a powerful tool for the discovery of novel genes involved in psychiatric disorders. This approach has strengths that are complementary to those of another genomic method for gene discovery, positional cloning. Microarray technologies and their application to post-mortem tissue and animal models of bipolar disorder are reviewed. A novel approach termed convergent functional genomics, which integrates gene profiling and positional cloning in order to rapidly identify candidate disease genes, is also described.
Niculescu
A B
AB
Department of Psychiatry, University of California, San Diego, USA. aniculescu@ucsd.edu
Kelsoe
J R
JR
D000661:Amphetamine; D000818:Animals; D001714:Bipolar Disorder / Q000139:chemically induced / Q000235:genetics*; D003001:Cloning, Molecular; D020869:Gene Expression Profiling; D008040:Genetic Linkage; D005824:Genetics, Behavioral; D006801:Humans; D051379:Mice; D023421:Models, Animal; D020411:Oligonucleotide Array Sequence Analysis / Q000379:methods; D016627:Oxidopamine; D051381:Rats; D012892:Sleep Deprivation / Q000503:physiopathology; D013566:Sympathomimetics
D013566:Sympathomimetics; D016627:Oxidopamine; D000661:Amphetamine