Identification of sequence selective receptors for peptides with a carboxylic acid terminus.
Split-and-mix libraries of resin-bound "tweezer" receptors have been prepared and screened to identify receptors for dye-labelled tripeptides. The receptors incorporate a diamidopyridine unit to serve as a specific recognition site for the CO2H group, leading to strong and selective receptors for peptide guests with a CO2H terminus. The role of the dye-label, attached to the peptide guest to allow visualisation of selective recognition events in the screening experiments, has also been examined and was found to have a significant influence on the binding selectivities.
Braxmeier
T
T
Department of Chemistry, University of Southampton, Highfield, UK.
Demarcus
M
M
Fessmann
T
T
McAteer
S
S
Kilburn
J D
JD
D000595:Amino Acid Sequence; D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D018716:Molecular Mimicry; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis / Q000378:metabolism*; D011485:Protein Binding; D018000:Receptors, Peptide / Q000737:chemistry* / Q000378:metabolism; D013379:Substrate Specificity
D019151:Peptide Library; D010455:Peptides; D018000:Receptors, Peptide