title: Fluid accumulation and the rapid spread of bacteria in the pathogenesis of external fixator pin track infection.
abstract: An animal model was used to study the pathogenesis of pin track infection. The roles of fluid accumulation around the pin/bone interface and mechanical loosening of the pin were specifically studied. In addition, the spread of bacteria in relation to the clinical appearance of the pin track was assessed. This study demonstrated that fluid accumulation around the interface is an important factor in the spread of infection from the superficial wound track to the medulla of the bone. Spread occurs despite the absence of mechanical pin loosening, and can occur before any clinical features of infection are apparent.
authors.affiliation: Department of Biomedical Sciences, DERA - CBD, Porton Down, Wiltshire SP4 0JQ, Salisbury, UK. medts@dera.gov.uk
authors.forename: J C
authors.initials: JC
authors.lastname: Clasper
authors.forename: L B
authors.initials: LB
authors.lastname: Cannon
authors.forename: S A
authors.initials: SA
authors.lastname: Stapley
authors.forename: V M
authors.initials: VM
authors.lastname: Taylor
authors.forename: P E
authors.initials: PE
authors.lastname: Watkins
mesh_terms: D000818:Animals; D001826:Body Fluids / Q000502:physiology; D001858:Bone Nails; D005260:Female; D005592:Fracture Fixation; D023421:Models, Animal; D016459:Prosthesis-Related Infections / Q000209:etiology*; D012756:Sheep; D013203:Staphylococcal Infections / Q000209:etiology* / Q000503:physiopathology; D019415:Torque