Homologous recombination: from model organisms to human disease.
Recent experiments show that properly controlled recombination between homologous DNA molecules is essential for the maintenance of genome stability and for the prevention of tumorigenesis.
Modesti
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M
Department of Cell Biology and Genetics, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands.
Kanaar
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D000818:Animals; D019313:BRCA1 Protein / Q000502:physiology; D024682:BRCA2 Protein; D004249:DNA Damage; D004265:DNA Helicases / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D008957:Models, Genetic; D009363:Neoplasm Proteins / Q000502:physiology; D009369:Neoplasms / Q000235:genetics; D051135:Rad51 Recombinase; D011995:Recombination, Genetic; D014157:Transcription Factors / Q000502:physiology
D019313:BRCA1 Protein; D024682:BRCA2 Protein; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D014157:Transcription Factors; C495153:RAD51 protein, human; D051135:Rad51 Recombinase; D004265:DNA Helicases