title: Measurement of allergenic potency using the local lymph node assay.
abstract: Chemicals that can act as contact allergens have been identified successfully using guinea-pig models. However, contact allergy is still common, probably because of, at least in part, failures of risk assessment. A new method, the local lymph node assay, replaces the guinea-pig as a tool for hazard identification and offers the real prospect of accurate prediction of allergen potency, the missing link in skin sensitization risk assessment.
authors.affiliation: SEAC Toxicology Unit, Unilever Research, Colworth House, Sharnbrook, Bedford, UK MK441LQ. David.Basketter@unilever.com
authors.forename: D A
authors.initials: DA
authors.lastname: Basketter
authors.forename: G F
authors.initials: GF
authors.lastname: Gerberick
authors.forename: I
authors.initials: I
authors.lastname: Kimber
mesh_terms: D000485:Allergens / Q000276:immunology; D000818:Animals; D006168:Guinea Pigs; D023441:Local Lymph Node Assay; D051379:Mice; D008808:Mice, Inbred CBA
chemical_list: D000485:Allergens