No leucine(7)-to-proline(7) polymorphism in the signal peptide of neuropeptide Y in Japanese population or Japanese with alcoholism.
We have screened 200 Japanese workers and 105 Japanese patients with alcoholism for the mutation in the signal peptide of pre-pro-neuropeptide Y resulting in a substitution of proline for leucine at position 7. This polymorphism was reported in the Finnish and Dutch populations recently. None of our subjects displayed the mutation at this site. Therefore, this allele does not play any role in the development of alcoholism in the Japanese population.
Drube
J
J
Division of Psychosomatic Research, National Institute of Mental Health, National Center of Neurology and Psychiatry, Chiba, Japan.
Kawamura
N
N
Nakamura
A
A
Ando
T
T
Komaki
G
G
Inada
T
T
D000437:Alcoholism / Q000235:genetics*; D019943:Amino Acid Substitution; D044466:Asian People; D004247:DNA / Q000097:blood; D004252:DNA Mutational Analysis; D017931:DNA Primers; D005784:Gene Amplification; D006778:Hospitals, Psychiatric; D006801:Humans; D007564:Japan; D007930:Leucine; D008969:Molecular Sequence Data; D009478:Neuropeptide Y / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011392:Proline; D021382:Protein Sorting Signals; D014041:Tokyo
D017931:DNA Primers; D009478:Neuropeptide Y; D021382:Protein Sorting Signals; D004247:DNA; D011392:Proline; D007930:Leucine