Domino hepatic transplantation using the liver from a patient with primary hyperoxaluria.
BACKGROUND
We report a case of domino liver transplantation using the liver harvested from a patient who underwent a combined liver and kidney transplantation for primary hyperoxaluria (PH).


METHODS
A cadaveric liver transplantation was performed in a 19-year-old man with PH. In a second step, the PH liver harvested from the first patient was transplanted in a 69-year-old man with hepatitis C-related cirrhosis, not a candidate for a classic liver graft owing to multifocal hepatocellular carcinoma.


RESULTS
At 8 months after transplantation, the domino recipient has normal hepatic function and no signs of tumoral recurrence, but he progressively developed hyperoxalemia, hyperoxaluria, and renal insufficiency.


CONCLUSIONS
Regarding the favorable postoperative clinical evolution, domino liver transplantations using livers from PH patients may represent a new opportunity for marginal candidates for liver transplantation. However, the progressive renal insufficiency expected in such domino recipients should limit this procedure to selected cases.
Donckier
V
V
Medicosurgical Department of Gastroenterology, Hĵpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. vdonckie@ulb.ac.be
El Nakadi
I
I
Closset
J
J
Ickx
B
B
Louis
H
H
Le Moine
O
O
Bourgeois
N
N
Adler
M
M
Gelin
M
M
D000328:Adult; D000368:Aged; D002102:Cadaver; D006801:Humans; D006959:Hyperoxaluria / Q000209:etiology / Q000601:surgery*; D008099:Liver; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D020858:Tissue and Organ Harvesting / Q000379:methods*; D009927:Tissue and Organ Procurement