Reconstructing smell.
Odorant signal transduction and neurogenesis are fundamental properties of the olfactory epithelium. Many preparations have been used to elucidate some of the mechanisms underlying these properties. In this article, we briefly review these research areas and describe some of the techniques used to obtain the data. We focus specifically on the cell-culture paradigm and the data obtained from various immortal cell lines in their attempts to reconstruct the olfactory epithelium in vitro.
Barber
R D
RD
Howard Hughes Medical Institute, and Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Ronnett
G V
GV
D000818:Animals; D018929:Cell Culture Techniques / Q000379:methods*; D002460:Cell Line; D006801:Humans; D009831:Olfactory Mucosa / Q000502:physiology*; D012903:Smell / Q000502:physiology*