Fruit and vegetable intake and population glycosylated haemoglobin levels: the EPIC-Norfolk Study.
OBJECTIVE
To investigate whether self-reported frequency of fruit and vegetable consumption was associated with HbA(1C) levels in individuals not known to have diabetes, and what dietary and lifestyle factors might explain this association.


METHODS
Cross-sectional study.


METHODS
The EPIC-Norfolk Study, a population-based cohort study of diet and chronic disease.


METHODS
A total of 2678 men and 3318 women (45-74 y) not known to have diabetes reported weekly consumption of fruit, green leafy vegetables and other vegetables.


RESULTS
Among men, 274 (10.2%) reported seldom or never eating fruit and 127 (4.7%) seldom or never eating green leafy vegetables. Corresponding numbers in women were 157 (4.7%) and 92 (2.8%), respectively. Participants who reported never or seldom having both fruit and green leafy vegetables had higher mean (s.d.) HbA(1C) measurements (5.43% (0.71)) than those who reported more frequent consumption (5.34% (0.67); P=0.046). Differences by category of fruit or green leafy vegetable consumption were not substantially changed after adjustment for saturated fat, dietary fibre and plasma vitamin C.


CONCLUSIONS
These findings support the hypothesis that high intake of fruit and green leafy vegetables may influence glucose metabolism independent of dietary fibre or vitamin C alone and that increased consumption may contribute to the prevention of diabetes.
Sargeant
L A
LA
Department of Public Health and Primary Care, University of Cambridge, Institute of Public Health, Cambridge, UK.
Khaw
K T
KT
Bingham
S
S
Day
N E
NE
Luben
R N
RN
Oakes
S
S
Welch
A
A
Wareham
N J
NJ
D000368:Aged; D001205:Ascorbic Acid / Q000097:blood; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000453:epidemiology / Q000517:prevention & control; D004043:Dietary Fiber / Q000378:metabolism; D005060:Europe; D005260:Female; D005638:Fruit; D005947:Glucose / Q000378:metabolism; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D014675:Vegetables
D001205:Ascorbic Acid; D004043:Dietary Fiber; D005947:Glucose; D006442:Glycated Hemoglobin