Pharmacokinetics of topical antifungal formulations.
The triad of infection--the dynamic equilibrium between pathogen, host, and drug--offers both opportunities and challenges for effectively delivering the right amount of drug to the right place for the right amount of time. The delivery system and drug must cooperate to achieve delivery and substantivity at the target site. Given the amount of variability introduced by the dosage form, it takes plenty of trial and error to get the right drug in the right vehicle so it can reach the targeted tissue. The deeper the target tissue, the greater the complexity of drug delivery and effect.
Reitberg
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D000287:Administration, Topical; D000935:Antifungal Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003881:Dermatomycoses / Q000188:drug therapy*; D006801:Humans; D009281:Naphthalenes / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine