Periarticular calcinosis associated with anti-Jo-1 antibodies sine myositis. Expanding the clinical spectrum of the antisynthetase syndrome.
We describe a 58-year-old woman who developed interstitial lung disease (ILD), polyarthritis, and anti-Jo-1 antibodies, with no clinical evidence of myositis. Despite successful treatment with corticosteroid and azathioprine for her arthritis and pulmonary condition, she developed deforming arthropathy of the hands, with periarticular calcinosis. The association of anti-Jo-1 antibodies, ILD, and periarticular calcinosis with subluxing arthropathy sine myositis is rare, with few cases reported. This report expands the clinical spectrum of the antisynthetase syndrome, which is broader than previously reported.
Queiro-Silva
R
R
Rheumatology Service, Complejo Hospitalario Donostia, and Rheumatology Unit, Hospital de Mendaro, San Sebastian-Guipúzcoa, Spain.
Bañegil
I
I
de Dios-Jiménez de Aberásturi
J R
JR
Belzunegui-Otano
J
J
González-Beneitez
C
C
Figueroa-Pedrosa
M
M
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D002114:Calcinosis / Q000276:immunology* / Q000473:pathology; D002574:Cervical Vertebrae / Q000473:pathology; D005260:Female; D006229:Hand Dermatoses / Q000276:immunology / Q000473:pathology; D006801:Humans; D008025:Ligases / Q000276:immunology*; D009220:Myositis; D011658:Pulmonary Fibrosis / Q000276:immunology* / Q000473:pathology; D014955:Wrist Joint / Q000473:pathology
D000974:Antibodies, Antinuclear; C046750:Jo-1 antibody; D008025:Ligases