title: Staged excision and split-thickness skin graft for circumferential perianal Paget's disease.
abstract: OBJECTIVE
  This study was designed to describe a surgical technique for the treatment of circumferential Paget's disease.
  
  
  METHODS
  A search of our computerized patient registry was undertaken, and case records for those patients with perianal Paget's disease were systematically reviewed.
  
  
  RESULTS
  Between July 1993 and October 1998, four patients with perianal Paget's disease were identified. Circumferential lesions were identified in three of the four patients. Wide local excision was considered the procedure of choice. All patients underwent a two-staged excision using split-thickness skin graft reconstruction. A similar second stage was performed six to eight weeks later; the other half of the circumference was excised and grafted. No patient had a protective stoma. Graft survival was 100 percent for two patients (four operations) and 80 percent and 70 percent for the other two patients (two operations). The remaining surface healed successfully by secondary intention. In one patient, residual disease was positive at one margin, and a third local excision and split-thickness skin graft was performed. Hospital stay ranged from five to nine days for each procedure. There were no major complications; one patient developed a mild anal stenosis three months after the second procedure and was successfully medically treated.
  
  
  CONCLUSIONS
  Staged excision and split-thickness skin graft is a viable option for the treatment of circumferential perianal lesions. It carries a minimal morbidity and no observed mortality, the functional result is good, and it is technically simple compared with myocutaneous grafts. Moreover, a stoma is not required.
authors.affiliation: Department of Colorectal Surgery, Cleveland Clinic Florida, Fort Lauderdale, Florida 33309, USA.
authors.forename: D T
authors.initials: DT
authors.lastname: Lam
authors.forename: O
authors.initials: O
authors.lastname: Batista
authors.forename: E G
authors.initials: EG
authors.lastname: Weiss
authors.forename: J J
authors.initials: JJ
authors.lastname: Nogueras
authors.forename: S D
authors.initials: SD
authors.lastname: Wexner
mesh_terms: D000368:Aged; D001005:Anus Neoplasms / Q000628:therapy*; D005260:Female; D006085:Graft Survival; D006801:Humans; D008297:Male; D010145:Paget Disease, Extramammary / Q000628:therapy*; D011183:Postoperative Complications; D016038:Skin Transplantation; D016896:Treatment Outcome