[Eosinophils and related chemokines].
Chemokines such as RANTES, eotaxin, MIP-1 and MCP-4 are considered to be involved in the pathophysiology of allergic inflammation because of their ability to drive eosinophils through their binding sites, chemokine receptors, expressed on eosinophils. Among those chemokines, RANTES and eotaxin are considered to play important roles in the process of the maturation, migration and activation of eosinophils. An overview of the effect of chemokines on eosinophils throughout their migration from bone marrow to the inflammatory focus is described in this paper. Furthermore, our observations on the effects of chemokines on eosinophils such as adherence through beta-2 integrin, the production of reactive oxygen species, intracellular EG2 content and production of RANTES by eosinophils are reported.
Kayaba
H
H
Central Clinical Laboratory and Department of Clinical and Laboratory Medicine, Akita University School of Medicine, Akita, 010-8543.
Chihara
J
J
D001249:Asthma / Q000209:etiology; D002465:Cell Movement; D054413:Chemokine CCL11; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000502:physiology; D018925:Chemokines / Q000502:physiology*; D019742:Chemokines, CC; D016207:Cytokines / Q000502:physiology; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology* / Q000276:immunology; D019402:Macrophage Inflammatory Proteins / Q000502:physiology; D018945:Monocyte Chemoattractant Proteins / Q000502:physiology
C515456:CCL11 protein, human; C099677:CCL13 protein, human; D054413:Chemokine CCL11; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D018925:Chemokines; D019742:Chemokines, CC; D016207:Cytokines; D019402:Macrophage Inflammatory Proteins; D018945:Monocyte Chemoattractant Proteins