Fluoxetine increases the content of neurotrophic protein S100beta in the rat hippocampus.
Recent studies indicate that a protracted daily administration of the antidepressant fluoxetine to adult rats increases cell proliferation/neurogenesis in the hippocampus. It has been hypothesized that this action of fluoxetine might be mediated by neurotrophic factors. We hypothesized that glial S100beta could be such a factor, and using quantitative Western immunoblotting, we investigated the effect of a 21-day treatment of rats with fluoxetine (5 mg/kg), and found that fluoxetine increases the content of hippocampal S100beta.
Manev
R
R
Department of Psychiatry, The Psychiatric Institute, University of Illinois at Chicago, 1601 West Taylor Street, MC912, Chicago, IL60612, USA.
Uz
T
T
Manev
H
H
D000818:Animals; D018687:Antidepressive Agents, Second-Generation / Q000494:pharmacology*; D002135:Calcium-Binding Proteins / Q000187:drug effects* / Q000378:metabolism; D005473:Fluoxetine / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D007274:Injections, Intraperitoneal; D009414:Nerve Growth Factors / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D011914:Rats, Inbred BN; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D013997:Time Factors
D018687:Antidepressive Agents, Second-Generation; D002135:Calcium-Binding Proteins; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; D005473:Fluoxetine