title: [Homonymous lateral hemianopsia revealing cerebral thrombophlebitis. Role of a deficiency of protein S induced by l-asparaginase].
abstract: BACKGROUND
  Cerebral thrombosis associated with protein S deficiency is very rare and is mainly related to hereditary form of protein S deficiency.
  
  
  METHODS
  A 19-year-old girl with acute lymphoblastic leukemia presented hemianopsy within a few days after the first administration of L-asparaginase. Magnetic resonance of the brain showed a cortical infarct. A marked decrease of the level of protein S was documented. Few days later, the patient was free of symptoms and protein S level was restored to the normal suggesting that the cerebral thrombosis was caused by transient protein S deficiency induced by L-asparaginase administration.
  
  
  CONCLUSIONS
  Patients with neurological complication caused by L-asparaginase should be tested for protein S and other anticoagulant deficiencies.
authors.affiliation: Service d'Oncologie hématologique et de Thérapie cellulaire, CHU de Poitiers, 350, avenue Jacques Coeur, BP 577, F 86021 Poitiers.
authors.forename: F
authors.initials: F
authors.lastname: Millot
authors.forename: P
authors.initials: P
authors.lastname: Traore
authors.forename: C
authors.initials: C
authors.lastname: Boinot
authors.forename: P
authors.initials: P
authors.lastname: Vandermarcq
authors.forename: A
authors.initials: A
authors.lastname: Sadoun
authors.forename: A
authors.initials: A
authors.lastname: Brizard
authors.forename: F
authors.initials: F
authors.lastname: Guilhot
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D001780:Blood Coagulation Tests; D002540:Cerebral Cortex / Q000473:pathology; D002544:Cerebral Infarction / Q000139:chemically induced / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006423:Hemianopsia / Q000139:chemically induced* / Q000175:diagnosis; D006801:Humans; D020766:Intracranial Embolism / Q000139:chemically induced* / Q000175:diagnosis; D008279:Magnetic Resonance Imaging; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy*; D018455:Protein S Deficiency / Q000139:chemically induced* / Q000175:diagnosis; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000175:diagnosis
chemical_list: D001215:Asparaginase