[Use of the acoustic startle response in the mouse to evaluate the pharmacodynamic action of ethanol].
A method of the pharmacological screening of psychotropic drugs that is based on the estimation of the peak amplitude and latency of the acoustic startle response (ASR) is suggested. A linear relationship between the changes of the ASR parameters induced by acute i.p. 14C-ethanol administration and its contents in brain is demonstrated. It is proposed that changes of the ASR parameters are strictly dependent upon the concentration of a modulatory drug in the biophase of action (brain, serum) and therefore can be utilised for the effector analysis of pharmacokinetics and preliminary screening of psychotropic drugs.
Kopanytsia
M V
MV
A. A. Bogomoletz Institute of Physiology, National Academy of Sciences of Ukraine, Kiev.
Vasylinin
H B
HB
Fedorova
O A
OA
Chekhovs'kyĭ
V P
VP
Zhuk
O V
OV
Zin'kovs'kyĭ
V H
VH
D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000378:metabolism; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D000431:Ethanol / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology; D013216:Reflex, Startle / Q000187:drug effects*
D002250:Carbon Radioisotopes; D002492:Central Nervous System Depressants; D011619:Psychotropic Drugs; D000431:Ethanol