Gender differences in the attenuation of salt-induced hypertension by angiotensin (1-7).
Chronic infusion of angiotensin (1-7) [Ang-(1-7)] lowers blood pressure in spontaneously hypertensive rats (SHR). To assess the role of Ang-(1-7) in salt-induced hypertension, Ang-(1-7) (24 microg/kg/hr) or saline was administered chronically via osmotic minipump into the jugular vein of 5-6 wk-old male (M) and female (F) Dahl salt-sensitive rats placed on a high-salt (8% NaCl) diet for 2 weeks. Blood pressure (BP) and heart rate were measured prior to the start of the diet and weekly thereafter. Ang-(1-7) significantly attenuated the BP increase after 1 wk on the diet in both M and F rats, but after 2 weeks only in F rats. Enhanced release of prostacyclin, (6-keto PGF1 alpha), following Ang-(1-7) treatment was observed in both M and F rats. In addition, significant increases in aortic blood flow and plasma levels of nitric oxide were observed in the F rats following Ang-(1-7) treatment. These findings demonstrate that the reduction in BP is due to both prostacyclin and NO and that there is a gender difference in the attenuation of salt-induced hypertension by Ang-(1-7).
Eatman
D
D
Department of Pharmacology and Toxicology, Morehouse School of Medicine, 720 Westview Drive, S.W., Atlanta, GA 30310-1495, USA.
Wang
M
M
Socci
R R
RR
Thierry-Palmer
M
M
Emmett
N
N
Bayorh
M A
MA
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000809:Angiotensins / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D015232:Dinoprostone / Q000097:blood; D011464:Epoprostenol / Q000097:blood / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008297:Male; D009569:Nitric Oxide / Q000097:blood; D051381:Rats; D020303:Rats, Inbred Dahl; D012492:Salts / Q000378:metabolism; D012737:Sex Factors; D013997:Time Factors
D000809:Angiotensins; D012492:Salts; D009569:Nitric Oxide; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D015232:Dinoprostone