Acute hepatitis induced by alpha-interferon in a patient with chronic hepatitis C.
Hepatic adverse effects occur very rarely with alpha-interferon therapy. A case of acute hepatitis induced by alpha-interferon in a 33-year-old man with chronic hepatitis C is described. The patient developed acute hepatitis with very high aminotransferase activity and jaundice. After discontinuing alpha-interferon therapy, hepatitis resolved rapidly. The immune-mediated mechanism is the most probable cause of this hepatitis.
Kraus
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University Hospital Centre Rijeka, Rijeka, Croatia.
Vitezic
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D000208:Acute Disease; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000998:Antiviral Agents / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D019698:Hepatitis C, Chronic / Q000628:therapy*; D006801:Humans; D007155:Immunologic Factors / Q000009:adverse effects*; D016898:Interferon-alpha / Q000009:adverse effects*; D007565:Jaundice / Q000139:chemically induced / Q000378:metabolism; D008297:Male
D000998:Antiviral Agents; D007155:Immunologic Factors; D016898:Interferon-alpha; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase