The Molecular Physiology of Sodium- and Proton-Coupled Solute Transporters.
The expression of cloned Na(+)- and H(+)-coupled solute transporters in Xenopus laevis oocytes has permitted detailed molecular and biophysical analysis and illuminated unique mechanistic features. The identification of missense mutations in inherited diseases and site-directed mutagenesis studies have enhanced our understanding of their roles in physiological and pathological processes.
Steel
Angela
A
Harvard Institutes of Medicine, 77 Ave. Louis Pasteur, Rm. 570, Boston, MA 02115, USA (E-mail: mhediger@rics.bwh.harvard.edu).
Hediger
Matthias A.
MA