title: Progress toward the total synthesis of ingenol: construction of the complete carbocyclic skeleton.
abstract: [reaction: see text] The complete carbocyclic skeleton of ingenol is assembled via a route that employs ring-closing metathesis (RCM) to close the strained "inside-outside" BC ring system (i.e., 24 --> 25).
authors.affiliation: Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
authors.forename: H
authors.initials: H
authors.lastname: Tang
authors.forename: N
authors.initials: N
authors.lastname: Yusuff
authors.forename: J L
authors.initials: JL
authors.lastname: Wood
mesh_terms: D019380:Anti-HIV Agents / Q000138:chemical synthesis; D000970:Antineoplastic Agents / Q000138:chemical synthesis; D004224:Diterpenes / Q000138:chemical synthesis*; D007509:Irritants / Q000138:chemical synthesis*
chemical_list: D019380:Anti-HIV Agents; D000970:Antineoplastic Agents; D004224:Diterpenes; D007509:Irritants; C008125:ingenol