title: [Tyrosine kinase inhibitor--hematological malignancies].
abstract: STI571 selectively inhibits the ABL-tyrosine kinase, the activity of which is activated by the formation of chimeric BCR/ABL. A phase I study in the USA showed STI571 to be remarkably effective in cases of interferon-refractory chronic myeloid leukemia, with almost no adverse effects. STI571 may become the first choice drug prior to stem cell transplantation and interferon treatment.
authors.affiliation: Aichi Cancer Center.
authors.forename: R
authors.initials: R
authors.lastname: Ohno
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D017321:Clinical Trials, Phase I as Topic; D004791:Enzyme Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D019833:Genistein / Q000627:therapeutic use; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy*; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D013343:Styrenes / Q000494:pharmacology / Q000627:therapeutic use*; D014212:Tretinoin / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D013343:Styrenes; C086531:ST 271; D014212:Tretinoin; D019833:Genistein; D011505:Protein-Tyrosine Kinases; D016044:Fusion Proteins, bcr-abl