title: Predictable multiple site root coverage using an acellular dermal matrix allograft.
abstract: BACKGROUND
  The primary aim of this randomized, controlled, blinded clinical investigation was to determine if orientation of an acellular dermal matrix (ADM) allograft, basement membrane side against the tooth or connective tissue side against the tooth, affected the percent root coverage. Additional aims were to: 1) compare results of this study with results obtained from other root coverage studies; 2) determine if multiple additional sites could be successfully covered with the same surgery; 3) determine the effect of the procedure on keratinized tissue; and 4) evaluate the amount of creeping attachment obtained.
  
  
  METHODS
  Ten patients with 2 Miller Class I or II buccal recession defects > or =3 mm were treated with a coronally positioned flap plus ADM and followed for 12 months. Test sites received ADM with the basement membrane side against the root (AB), while the control sites received the connective tissue side against the root (AC). Multiple additional recession sites were treated with the same flap procedure.
  
  
  RESULTS
  Mean baseline recession for the AB sites was 4.2 mm and for the AC sites, 3.7 mm. Mean root coverage of 95% was obtained for both AB and AC sites. Sixty-eight additional Class I or II AB and AC sites obtained about 93% root coverage. The mean increase in keratinized tissue for both treatments was 0.80 mm. No additional root coverage was gained due to creeping attachment between 2 and 12 months.
  
  
  CONCLUSIONS
  Treatment with ADM was an effective and predictable procedure for root coverage. The orientation of the material did not affect the treatment outcome for any of the parameters tested.
authors.affiliation: School of Dentistry, University of Louisville, KY 40292, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Henderson
authors.forename: H
authors.initials: H
authors.lastname: Greenwell
authors.forename: C
authors.initials: C
authors.lastname: Drisko
authors.forename: F J
authors.initials: FJ
authors.lastname: Regennitter
authors.forename: J W
authors.initials: JW
authors.lastname: Lamb
authors.forename: M J
authors.initials: MJ
authors.lastname: Mehlbauer
authors.forename: L J
authors.initials: LJ
authors.lastname: Goldsmith
authors.forename: G
authors.initials: G
authors.lastname: Rebitski
mesh_terms: D000328:Adult; D000368:Aged; D001485:Basement Membrane / Q000473:pathology / Q000637:transplantation; D003238:Connective Tissue / Q000473:pathology / Q000637:transplantation; D003774:Dental Plaque Index; D005260:Female; D005500:Follow-Up Studies; D005881:Gingiva / Q000473:pathology / Q000503:physiopathology; D005884:Gingival Hemorrhage / Q000601:surgery; D005889:Gingival Recession / Q000145:classification / Q000473:pathology / Q000601:surgery*; D005893:Gingivoplasty / Q000379:methods; D006801:Humans; D007633:Keratins; D008297:Male; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000601:surgery; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000601:surgery; D016037:Single-Blind Method; D016038:Skin Transplantation / Q000379:methods* / Q000473:pathology; D013223:Statistics as Topic; D013524:Surgical Flaps; D014092:Tooth Root / Q000473:pathology*; D014184:Transplantation, Homologous; D014945:Wound Healing
chemical_list: D007633:Keratins