title: A randomized controlled trial comparing amoxicillin and azithromycin for the treatment of Chlamydia trachomatis in pregnancy.
abstract: OBJECTIVE
  Our goal was to compare the efficacy of azithromycin with that of amoxicillin for the treatment of Chlamydia trachomatis infection during pregnancy.
  
  
  METHODS
  A randomized controlled trial of pregnant women with cervical C trachomatis infection receiving care at two inner-city, university-based prenatal clinics. Pregnant women were randomly assigned to receive either oral amoxicillin, 500 mg, three times daily for 7 days, or oral azithromycin, 1 g, in a single dose. Partners were referred for treatment. Tests of cure were scheduled 4 weeks after initiation of treatment. Statistical analysis was performed by using the Student t test and chi2 analysis.
  
  
  RESULTS
  One hundred twenty-nine pregnant women were enrolled, and 110 (85%) completed the protocol. There was similar treatment efficacy between amoxicillin and azithromycin (58% vs 64%, respectively,P =.56). In the amoxicillin group 3 women (5.5%) were intolerant, compared with 6 (10.9%) in the azithromycin group (P =.31).
  
  
  CONCLUSIONS
  Amoxicillin and azithromycin are equally efficacious in the treatment of cervical C trachomatis during pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology at University of Wisconsin Medical School-Milwaukee Clinical Campus, Wisconsin 53233, USA.
authors.forename: G F
authors.initials: GF
authors.lastname: Jacobson
authors.forename: A M
authors.initials: AM
authors.lastname: Autry
authors.forename: R S
authors.initials: RS
authors.lastname: Kirby
authors.forename: E M
authors.initials: EM
authors.lastname: Liverman
authors.forename: R U
authors.initials: RU
authors.lastname: Motley
mesh_terms: D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000627:therapeutic use*; D017963:Azithromycin / Q000009:adverse effects / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010406:Penicillins / Q000009:adverse effects / Q000627:therapeutic use*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D000658:Amoxicillin; D017963:Azithromycin