[Single-strand DNA breaks in brain cells of different rat strains under normal condition and during exposure to stress].
This study was aimed to characterize pattern of occurrence of spontaneous single-strand breaks in situ in glial and neuronal nuclei of the cortex, middle brain and hyppocapmi (CA3 field) of rats selected for a threshold of nervous system excitability, and to study the influence of stress of various modality on such breaks. The results obtained evidence that: 1) intact animals possess a subpopulation of glial and neuronal cells revealed following gap filling in situ in opposite to other types of terminally differentiated non-proliferating cells; 2) the size of such a subpopulation differs depending on the lines of examined rats, parts of brain, and the type of stress.
Patkin
E L
EL
Institute of Experimental Medicine RAMS, St. Petersburg, and Physiological Institute RAS, St. Petersburg.
Vaĭdo
A I
AI
Kustova
M E
ME
Shiriaeva
N V
NV
Lopatina
N G
NG
D000818:Animals; D001921:Brain / Q000648:ultrastructure*; D004249:DNA Damage; D004277:DNA, Single-Stranded / Q000648:ultrastructure*; D008297:Male; D009474:Neurons / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity; D013315:Stress, Psychological / Q000235:genetics*
D004277:DNA, Single-Stranded