title: New functions of stromal proteases and their inhibitors in tumor progression.
abstract: Acquisition of invasive metastatic potential through protease expression is a key event in tumor progression. In carcinomas, the production of metalloproteinases and serine proteinases is regulated by a cross talk between stromal cells and cancer cells. Paradoxically, high rather than low levels of their inhibitors predict poor survival of patients suffering from a variety of cancers. Recent observations suggest a much more complex role of these inhibitors in tumor progression than expected initially.
authors.affiliation: Laboratory of Tumor and Developmental Biology, University of Liege, Tour de Pathologie, Liege, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: Noel
authors.forename: V
authors.initials: V
authors.lastname: Albert
authors.forename: K
authors.initials: K
authors.lastname: Bajou
authors.forename: C
authors.initials: C
authors.lastname: Bisson
authors.forename: L
authors.initials: L
authors.lastname: Devy
authors.forename: F
authors.initials: F
authors.lastname: Frankenne
authors.forename: E
authors.initials: E
authors.lastname: Maquoi
authors.forename: V
authors.initials: V
authors.lastname: Masson
authors.forename: N E
authors.initials: NE
authors.lastname: Sounni
authors.forename: J M
authors.initials: JM
authors.lastname: Foidart
mesh_terms: D018450:Disease Progression; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D020782:Matrix Metalloproteinases / Q000502:physiology*; D009362:Neoplasm Metastasis / Q000188:drug therapy* / Q000235:genetics / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000235:genetics / Q000503:physiopathology; D010958:Plasminogen / Q000502:physiology; D011480:Protease Inhibitors / Q000627:therapeutic use*; D012697:Serine Endopeptidases / Q000502:physiology*; D017154:Stromal Cells / Q000201:enzymology*
chemical_list: D061965:Matrix Metalloproteinase Inhibitors; D011480:Protease Inhibitors; D010958:Plasminogen; D012697:Serine Endopeptidases; D020782:Matrix Metalloproteinases