Phospholipase C Isoforms, Cytoskeletal Organization, and Vascular Smooth Muscle Differentiation.
The function of differentiated vascular smooth muscle cells (VSMC) in vivo is the regulation of contractility. Following injury or disease, however, VSMC lose their contractile function and take on a synthetic, proliferative phenotype. This dedifferentiation is generally accompanied by a change in the expression profile of phospholipase C isoforms.
Lymn
Joanne S.
JS
Department of Clinical Pharmacology, National Heart and Lung Institute, Imperial College School of Medicine, QEQM Wing, St. Mary's Hospital, Paddington, London W2 1NY, England.
Hughes
Alun D.
AD