title: Deep cerebral venous thrombosis: an illustrative case with reversible diencephalic dysfunction.
abstract: BACKGROUND
  Isolated thrombosis of the deep cerebral veins is rare and its diagnosis can be difficult. Mortality is often high and little is known about the long-term prognosis.
  
  
  METHODS
  We report a 24-year-old woman with akinetic mutism and extensive bilateral thalamic lesions. CT and MRI allowed early diagnosis by demonstrating thrombosis within the internal cerebral veins, without the need for angiography. Heparin treatment was used safely despite the presence of thalamic and intraventricular hemorrhage. After five weeks, the patient recovered rapidly and remains well at 18 months. Serial MRI showed dramatic resolution of the imaging abnormalities.
  
  
  CONCLUSIONS
  The clinical features and characteristic neuroimaging appearance of deep cerebral venous thrombosis should be recognized by physicians caring for stroke patients. Deep cerebral venous thrombosis can produce extensive venous congestion and vasogenic edema without early infarction. Excellent clinical recovery is possible even after severe and prolonged neurological deficits.
authors.affiliation: University of Toronto and the Royal College of Physicians and Surgeons of Canada Clinician-Investigator Program, Ontario.
authors.forename: D J
authors.initials: DJ
authors.lastname: Gladstone
authors.forename: F L
authors.initials: FL
authors.lastname: Silver
authors.forename: R A
authors.initials: RA
authors.lastname: Willinsky
authors.forename: F J
authors.initials: FJ
authors.lastname: Tyndel
authors.forename: R
authors.initials: R
authors.lastname: Wennberg
mesh_terms: D000328:Adult; D000405:Akinetic Mutism / Q000209:etiology / Q000473:pathology*; D004027:Diencephalon / Q000473:pathology*; D005260:Female; D006801:Humans; D020767:Intracranial Thrombosis / Q000150:complications / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D011379:Prognosis; D020127:Recovery of Function; D020246:Venous Thrombosis / Q000150:complications / Q000473:pathology*