title: Repair of truncus arteriosus in early infancy with antibiotic sterilized aortic homografts.
abstract: BACKGROUND
  To evaluate the fate of the truncal valve, the antibiotic sterilized aortic homografts, and the survival after repair of truncus arteriosus in the first 6 months of life.
  
  
  METHODS
  Between 1974 and 1994, 23 infants (mean age 1.7 months, range 5 days to 6 months) underwent primary repair of truncus arteriosus by one surgeon (J.L.M). Sixteen were neonates (age range 5 to 30 days). Continuity between the right ventricle and the pulmonary artery was established with an aortic antibiotic sterilized homograft (mean diameter 14.9 mm, range 11 to 17 mm). Follow-up was 100% complete.
  
  
  RESULTS
  Four neonates with severe truncal regurgitation died early (17.4%). Fourteen patients underwent reoperations. Five had a truncal valve replacement (mean time 7 years, range 6 months to 17 years). Ten-year freedom from truncal valve replacement was 78.2%. Eleven patients had homograft replacement (mean time 12.7 years, range 2 to 26.2 years). Ten-year freedom from homograft replacement for any cause was 77.1% (for homograft-related problems it was 86.7%). Seven patients retained the original homografts (mean time 14.3 years, range 6 to 18.7 years). There was one late death. Overall 10-year survival was 79% and for the hospital survivors it was 95%. All survivors are in New York Heart Association functional class I.
  
  
  CONCLUSIONS
  Abnormal truncal valves pose serious early and late problems but the patients with normal truncal valves do well and seem unlikely to need replacement of these valves. The durability of the antibiotic sterilized aortic homograft even in sizes less than 14 mm is remarkably good. Late survival is excellent.
authors.affiliation: Department of Cardiac Surgery, The General Hospital, Southampton, United Kingdom.
authors.forename: C
authors.initials: C
authors.lastname: Alexiou
authors.forename: B R
authors.initials: BR
authors.lastname: Keeton
authors.forename: A P
authors.initials: AP
authors.lastname: Salmon
authors.forename: J L
authors.initials: JL
authors.lastname: Monro
mesh_terms: D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006351:Heart Valves / Q000637:transplantation*; D006352:Heart Ventricles / Q000601:surgery; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011651:Pulmonary Artery / Q000601:surgery; D012086:Reoperation; D013242:Sterilization; D013530:Surgical Wound Infection / Q000517:prevention & control*; D015996:Survival Rate; D014184:Transplantation, Homologous; D014339:Truncus Arteriosus, Persistent / Q000401:mortality / Q000601:surgery*
chemical_list: D000900:Anti-Bacterial Agents