Malignancy: Tumor Suppressor Gene Aberrations in Acute Myelogenous Leukemia.
Acute myelogenous leukemia is a heterogeneous disease that appears to evade the normal regulatory controls of tumor suppressor genes. Studies in AML have documented mutations in both p53 and Retinoblastoma (Rb) genes, but these mutations are relatively uncommon, especially compared to their mutational frequency in solid tumors. In addition, expression abnormalities have now been documented in several tumor suppressor genes or related genes including MDM2, p73, Rb, p14(ARF), p15(INK4B), and p16(INK4A). We review the current literature regarding tumor suppressor genes in AML and suggest how these genes may be involved in the development of the disease.
Stirewalt
DEREK L.
DL
Clinical Research Division, Fred Hutchinson Cancer Research Center, and the Division of Oncology, University of Washington, Seattle, Washington.
Radich
JERALD P.
JP