Chemotaxis of human CD4+ eosinophils.
We reviewed the biological functions of CD4+ eosinophils, which are observed in peripheral blood, sputum and bronchoalveolar lavage fluid of various diseases. We have shown that CD4 molecules on human eosinophils are induced by tumor necrosis factor-alpha (TNF-alpha) stimulation. Interleukin-16 (IL-16) has been reported to bind a natural soluble ligand for the CD4 molecule. We reported that TNF-alpha-stimulated eosinophils migrate in a time- and dose-dependent manner against IL-16. Theophylline and dexamethasone significantly inhibited CD4 expression. Theophylline inhibited CD4+ eosinophil chemotaxis, but dexamethasone did not. Theophylline may prevent airway inflammation by downregulating the expression of CD4 molecule and CD4+ eosinophil migration. However, dexamethasone may inhibit airway inflammation through the downregulation of CD4 expression.
Okubo
Y
Y
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan. okuboyo@hsp.md.shinshu-u.ac.jp
Tsukadaira
A
A
Takashi
S
S
Kubo
K
K
Koyama
S
S
D001249:Asthma / Q000276:immunology; D015704:CD4 Antigens / Q000032:analysis*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D004804:Eosinophils / Q000276:immunology*; D006801:Humans; D019410:Interleukin-16 / Q000502:physiology; D018448:Models, Immunological; D013806:Theophylline / Q000494:pharmacology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D015704:CD4 Antigens; D019410:Interleukin-16; D014409:Tumor Necrosis Factor-alpha; D003907:Dexamethasone; D013806:Theophylline