title: [Participation of various types of serotonin receptors in the regulation of drinking behavior and salt appetite in rats].
abstract: The 5-HT1A agonist 8-OH-DPAT was shown to diminish the water and 1.8% NaCl solution consumption, whereas its antagonist pMPPI--to enhance the water intake in rats. Another agonist: CGS-12066A enhanced water intake or exerted no effect on drinking behaviour and diminished salt intake. Other substances under study exerted various effects. The data obtained suggest that the 5-HT receptors are involved in regulation of water and salt intake, even though the mechanisms of the effects are different. Apparently 5-HT1B and 5-HT2A receptors play an activating role in regulation of water intake, whereas 5-HT1A, 5-HT2C and 5-HT3 receptors act as inhibitory ones. Only three of the receptors under study seem to regulate salt intake by inhibiting the salt appetite.
authors.affiliation: Institute of Cytology and Genetics, Russian Acad. Sci., Siberian Branch, Russia, 630090, Novocibirsk, Pr. Lavrentyeva, 10.
authors.forename: K S
authors.initials: KS
authors.lastname: Naumenko
authors.forename: N K
authors.initials: NK
authors.lastname: Popova
authors.forename: L N
authors.initials: LN
authors.lastname: Ivanova
mesh_terms: D000818:Animals; D001069:Appetite Regulation / Q000187:drug effects / Q000502:physiology*; D004326:Drinking; D004327:Drinking Behavior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D044302:Receptor, Serotonin, 5-HT1B; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D044263:Receptors, Serotonin, 5-HT1; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists / Q000494:pharmacology; D017366:Serotonin Receptor Agonists / Q000494:pharmacology; D017673:Sodium Chloride, Dietary
chemical_list: D044302:Receptor, Serotonin, 5-HT1B; D044402:Receptor, Serotonin, 5-HT2A; D044405:Receptor, Serotonin, 5-HT2C; D011985:Receptors, Serotonin; D044263:Receptors, Serotonin, 5-HT1; D044406:Receptors, Serotonin, 5-HT3; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D017673:Sodium Chloride, Dietary