title: Optimization of residual water signal removal by HLSVD on simulated short echo time proton MR spectra of the human brain.
abstract: Suppression of the residual water signal from proton magnetic resonance (MR) spectra recorded in human brain is a prerequisite to an accurate quantification of cerebral metabolites. Several postacquisition methods of residual water signal suppression have been reported but none of them provide a complete elimination of the residual water signal, thereby preventing reliable quantification of brain metabolites. In the present study, the elimination of the residual water signal by the Hankel Lanczos singular value decomposition method has been evaluated and optimized to provide fast automated processing of spectra. Model free induction decays, reproducing the proton signal acquired in human brain localized MR spectroscopy at short echo times (e.g., 20 ms), have been generated. The optimal parameters in terms of number of components and dimension of the Hankel data matrix allowing complete elimination of the residual water signal are reported.
authors.affiliation: Centre de Résonance Magnétique Biologique et Médicale, UMR CNRS 6612, Faculté de Médecine de Marseille, 27 Boulevard Jean Moulin, 13005 Marseille, France.
authors.forename: E
authors.initials: E
authors.lastname: Cabanes
authors.forename: S
authors.initials: S
authors.lastname: Confort-Gouny
authors.forename: Y
authors.initials: Y
authors.lastname: Le Fur
authors.forename: G
authors.initials: G
authors.lastname: Simond
authors.forename: P J
authors.initials: PJ
authors.lastname: Cozzone
mesh_terms: D001834:Body Water; D001923:Brain Chemistry; D003198:Computer Simulation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D008954:Models, Biological