Expression of nm23-H1 in hydatidiform mole and its relationship with the development of postmolar disease.
The aim of the present study was to investigate the expression of nm23-H1 in human placenta, hydatidiform mole and choriocarcinoma cells. Nm23-H1 protein was localized in the cytotrophoblast, but not in the syncytiotrophoblast. In the hydatidiform mole cases with subsequent spontaneous remission, nm23-H1 mRNA levels were significantly lower than those in first-trimester placentas. However, its levels were elevated in the hydatidiform mole cases that progressed to persistent gestational trophoblastic disease and were comparable to those of first-trimester placentas, and they were further elevated in choriocarcinoma cells. The present data suggest an association of nm23-H1 for the proliferation activity of trophoblast, and its increased expression may influence the development of persistent trophoblastic disease.
Iwase
K
K
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Nagoya, Japan.
Okamoto
T
T
Nui
R
R
Mizutani
S
S
D015152:Blotting, Northern; D002822:Choriocarcinoma / Q000737:chemistry; D005260:Female; D005865:Gestational Age; D006801:Humans; D006828:Hydatidiform Mole / Q000737:chemistry* / Q000150:complications*; D007150:Immunohistochemistry; D020559:Monomeric GTP-Binding Proteins / Q000032:analysis* / Q000235:genetics; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D010920:Placenta / Q000737:chemistry; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis; D014157:Transcription Factors / Q000032:analysis* / Q000235:genetics; D014328:Trophoblastic Neoplasms / Q000737:chemistry / Q000209:etiology*; D014327:Trophoblasts / Q000737:chemistry; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms / Q000737:chemistry* / Q000150:complications*
D054778:NM23 Nucleoside Diphosphate Kinases; D012333:RNA, Messenger; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins