Development of genetic hypotheses in essential hypertension.
Essential hypertension illustrates the formidable task presented by the identification of genetic determinants of common disease. Making an initial genetic inference may prove difficult enough; the subsequent demonstration of functional significance at various levels of biological integration may be even more challenging. We review three instances in which an initial genetic inference has led to the development of testable hypotheses pursued at increasingly higher levels of biological organization. These include the adducin, the G protein beta3 subunit, and the angiotensinogen hypotheses.
Lalouel
J M
JM
Department of Human Genetics, University of Utah, Salt Lake City 84112-5331, USA. jml@howard.genetics.utah.edu
Rohrwasser
A
A
D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D002148:Calmodulin-Binding Proteins / Q000235:genetics; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D008957:Models, Genetic; D021122:Protein Subunits; D000099291:Adducins
D000808:Angiotensinogen; D002148:Calmodulin-Binding Proteins; D020962:Heterotrimeric GTP-Binding Proteins; D021122:Protein Subunits; D000099291:Adducins