Distribution of methylmercury and inorganic mercury in neonate hamsters dosed with methylmercury during fetal life.
The study of the effects of methylmercury (MeHg) contamination has intensified since the MeHg outbreaks in Japan and Iraq. However, most of these studies used high doses of MeHg to obtain its most severe effects. This work identified the MeHg targets in neonate hamsters after administration of two different single oral doses of radiolabeled methylmercury chloride (Me203HgCl) to two groups of pregnant hamsters. The low-dose group received 0.05 microg of 203Hg as Me203HgCl per gram of body weight and the radioactivity was 6.6x10(3) Bq. The high-dose group received 0.55 microg of 203Hg as Me203HgCl per gram of body weight with 2x104 Bq. In the first day of life, the brain was the organ with the highest Me203Hg concentration, followed by the liver, kidneys, and intestines. However, these values of Me203Hg decreased at different rates in all organs until 12 days of life, whereas total 203Hg in the body did not change during the same period. This suggests an age-dependent Me203Hg body distribution instead of an elimination of Me203Hg from the body.
Oliveira
R B
RB
Laboratório de Neurobiologia, Universidade Federal do Pará, Santarem, 660-10, Brazil.
Malm
O
O
Guimarães
J R
JR
D000818:Animals; D000831:Animals, Newborn; D002855:Chromatography, Thin Layer; D006224:Cricetinae; D005260:Female; D018811:Maternal Exposure; D008431:Maternal-Fetal Exchange; D008628:Mercury / Q000493:pharmacokinetics*; D008631:Mercury Radioisotopes; D008647:Mesocricetus; D008767:Methylmercury Compounds / Q000493:pharmacokinetics*; D011247:Pregnancy; D014018:Tissue Distribution; D014873:Water Pollutants / Q000493:pharmacokinetics*
D008631:Mercury Radioisotopes; D008767:Methylmercury Compounds; D014873:Water Pollutants; D008628:Mercury; C004925:methylmercuric chloride