Formal synthesis of uvaricin via palladium-mediated double cyclization.
[see reaction]. A novel palladium-mediated, ligand-controlled double cyclization is reported. The C2-symmetric diene produced was desymmetrized via Sharpless asymmetric dihydroxylation and was further transformed into a known intermediate in the synthesis of uvaricin.
Burke
S D
SD
Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706-1396, USA. burke@chem.wisc.edu
Jiang
L
L
D005663:Furans / Q000138:chemical synthesis* / Q000737:chemistry; D010165:Palladium / Q000737:chemistry*
D005663:Furans; D010165:Palladium; C046852:uvaricin