Paesslerins A and B: novel tricyclic sesquiterpenoids from the soft coral Alcyonium paessleri.
[structure: see text] In the course of our search of new bioactive metabolites from marine invertebrates, paesslerins A and B, sesquiterpenoids with an unprecedented tricyclic skeleton, were isolated from the subAntarctic soft coral Alcyonium paessleri collected at a depth of 200 m near the South Georgia islands, and their structures were elucidated by spectroscopic techniques. These compounds show moderate cytotoxicity in preliminary assays.
Rodríguez Brasco
M F
MF
Departamento de Química Orgánica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria Pab. 2, (1428) Buenos Aires, Argentina.
Seldes
A M
AM
Palermo
J A
JA
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001685:Biological Factors / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D006801:Humans; D008386:Marine Biology; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D000078329:Workforce
D000970:Antineoplastic Agents; D001685:Biological Factors; D001952:Bridged-Ring Compounds; D012717:Sesquiterpenes; C438968:paesslerin A; C438969:paesslerin B