title: Anisotropy in high angular resolution diffusion-weighted MRI.
abstract: The diffusion in voxels with multidirectional fibers can be quite complicated and not necessarily well characterized by the standard diffusion tensor model. High angular resolution diffusion-weighted acquisitions have recently been proposed as a method to investigate such voxels, but the reconstruction methods proposed require sophisticated estimation schemes. We present here a simple algorithm for the identification of diffusion anisotropy based upon the variance of the estimated apparent diffusion coefficient (ADC) as a function of measurement direction. The rationale for this method is discussed, and results in normal human subjects acquired with a novel diffusion-weighted stimulated-echo spiral acquisition are presented which distinguish areas of anisotropy that are not apparent in the relative anisotropy maps derived from the standard diffusion tensor model. Published 2001 Wiley-Liss, Inc.
authors.affiliation: Department of Radiology, San Diego VA Healthcare System and University of California-San Diego, San Diego, California 92161, USA.
authors.forename: L R
authors.initials: LR
authors.lastname: Frank
mesh_terms: D000465:Algorithms; D016880:Anisotropy; D001921:Brain / Q000033:anatomy & histology*; D004058:Diffusion; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D012016:Reference Values