Effects of the flavonoids extracted from Spergularia purpurea Pers. on arterial blood pressure and renal function in normal and hypertensive rats.
The antihypertensive and diuretic effects of the flavonoids extracted from Spergularia purpurea Pers. (SP) were studied both in normotensive (NTR) and spontaneously hypertensive conscious rats (SHR). Daily oral administration of the flavonoid mixture (5 mg/kg for 1 week) exhibited a significant decrease in blood pressure with variation coefficient (Delta) of 20 in SHR rats and 11 in NTR rats. The systolic and diastolic blood pressure decreased significantly and respectively with 17 and 24% in SHR, and with 11 and 16% in NTR. The flavonoid mixture enhanced significantly the water excretion in hypertensive (P<0.001) and normal rats (P<0.001). Furthermore, oral administration of flavonoids mixture at a dose of 5 mg/kg produced a significant increase of urinary excretion of sodium (P<0.01), potassium (P<0.05) and chlorides (P<0.05) in SHR. Similarly, the flavonoid administration induced a significant increase of urinary electrolytes elimination in NTR (P<0.01 versus controls). No significant changes were noted on heart rate after flavonoids treatment in SHR as well as in NTR. While, glomerular filtration rate showed a significant increase after administration of flavonoids in all groups (P<0.05). These results suggest that oral administration of flavonoids obtained from Spergularia purpurea exhibited antihypertensive and diuretic actions.
Jouad
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H
Laboratory of Endocrinian Physiology and Pharmacology. F.S.T.B. Boutalamine, B.P. 509, Errachidia, Morocco.
Lacaille-Dubois
M A
MA
Lyoussi
B
B
Eddouks
M
M
D000284:Administration, Oral; D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000302:isolation & purification / Q000494:pharmacology*; D005419:Flavonoids / Q000008:administration & dosage / Q000302:isolation & purification / Q000494:pharmacology*; D006973:Hypertension / Q000188:drug therapy*; D007668:Kidney / Q000187:drug effects*; D007677:Kidney Function Tests; D008297:Male; D010936:Plant Extracts / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar
D000959:Antihypertensive Agents; D004232:Diuretics; D005419:Flavonoids; D010936:Plant Extracts