Antiphospholipid syndrome: ultrastructure of microvascular endotheliocytes in musculocutaneous bioptates during systemic lupus erythematosus.
Degeneration and atrophy of the epidermis, disorganization of the connective tissue, focal atrophy of skeletal myocytes, and diffuse vasculopathy are the main pathomorphological signs found in musculocutaneous bioptates during the antiphospholipid syndrome associated with systemic lupus erythematosus. The major morphogenetic disorder is alteration of microvascular endotheliocytes accompanied by the formation of concentric perivascular mononuclear infiltrates.
Chapaeva
N N
NN
Laboratory of Ultrastructural Bases of Pathology, Institute of Regional Pathology and Pathomorphology, Siberian Division of the Russian Academy of Medical Sciences, Siberia, Russia. pathol@ cyber.ma.nsc.ru
Nepomnyashchikh
G I
GI
Aidagulova
S V
SV
Bakarev
M A
MA
D000273:Adipose Tissue / Q000098:blood supply / Q000473:pathology; D016736:Antiphospholipid Syndrome / Q000473:pathology*; D001706:Biopsy; D004730:Endothelium, Vascular / Q000473:pathology* / Q000648:ultrastructure; D004817:Epidermis / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000473:pathology*; D018482:Muscle, Skeletal / Q000098:blood supply / Q000473:pathology; D012867:Skin / Q000098:blood supply / Q000473:pathology