title: NMR methodology for the study of nucleic acids.
abstract: During the past few years, NMR methodology for the study of nucleic acids has benefited from new developments that greatly improved state-of-the-art technology for the precise determination of three-dimensional structures. Substantial progress has been made in designing experimental protocols for the measurement of residual dipolar couplings, in sensitivity optimization of triple-resonance experiments and in detection of hydrogen bonds and in developing computational methods for structure refinement using NMR restraints.
authors.affiliation: National Centre for Biomolecular Research, Masaryk University, Kotlárská 2, 611 37, Brno, Czech Republic.
authors.forename: L
authors.initials: L
authors.lastname: Zídek
authors.forename: R
authors.initials: R
authors.lastname: Stefl
authors.forename: V
authors.initials: V
authors.lastname: Sklenár
mesh_terms: D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D009696:Nucleic Acids / Q000737:chemistry; D012313:RNA / Q000737:chemistry* / Q000378:metabolism; D012680:Sensitivity and Specificity; D012997:Solvents
chemical_list: D009696:Nucleic Acids; D012997:Solvents; D012313:RNA; D004247:DNA