title: On T2-shortening by weakly magnetized particles: the chemical exchange model.
abstract: Chemical exchange (CE) theory is compared with two theories of T2-shortening caused by microscopic magnetic centers: inner- and outer-sphere relaxation theory (long-echo limit) and mean gradient diffusion theory (short-echo limit). The CE equation is shown to be identical to these theories in the respective limits and appropriate parameter relationships are derived for spherical particles. The theories are then compared with computer simulations of spherical particles and with a recent general theory, with good agreement in the asymptotic regions. The CE model also reproduces the essential relaxation characteristics in the intermediate range. Finally, good agreement of a CE model with simulations for magnetized cylinders is also demonstrated. The discussion is limited to weakly magnetized particles such that the maximum phase shift during an echo interval is less than one radian, permitting the use of the Luz-Meiboom CE equation. Published 2001 Wiley-Liss, Inc.
authors.affiliation: Neuroimaging Branch, NINDS, National Institutes of Health, Bethesda, Maryland, USA. RodneyABrooks@cs.com
authors.forename: R A
authors.initials: RA
authors.lastname: Brooks
authors.forename: F
authors.initials: F
authors.lastname: Moiny
authors.forename: P
authors.initials: P
authors.lastname: Gillis
mesh_terms: D003198:Computer Simulation; D003287:Contrast Media / Q000494:pharmacology; D004058:Diffusion; D017352:Echo-Planar Imaging; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008280:Magnetics
chemical_list: D003287:Contrast Media