Neutrophil diapedesis: paracellular or transcellular?
To reach an inflammatory site in the interstitium, circulating neutrophils (PMN) must first traverse the endothelial barrier. Whether PMN emigrate between endothelial cells (paracellular pathway) or through the endothelial cells proper (transcellular pathway) is controversial. Herein, we present anatomic, functional, and teleological arguments that support both points of view. An attempt is also made to reconcile this apparent controversy.
Kvietys
P R
PR
Vascular Biology Program at the Lawson Health Research Institute, London, ON N6A 4G5, Canada.
Sandig
M
M
D000818:Animals; D002465:Cell Movement / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology*; D006801:Humans; D009504:Neutrophils / Q000166:cytology*