title: Clinical options for imipramine in the management of urinary incontinence.
abstract: Urinary incontinence is a common disorder in both childhood and adulthood. Proper treatment depends on insight into the pathophysiology and pharmacology of the lower urinary tract. This article reviews the mechanism of action of an old but commonly used drug, the tricyclic antidepressant agent imipramine, in nocturnal enuresis and stress and urge incontinence with reference to neuropharmacology and the relevant pathophysiology.
authors.affiliation: International Enuresis Research Centre at the Institute of Experimental Clinical Research, University of Aarhus, Skejby University Hospital, Denmark. janjen@mail.tele.dk
authors.forename: J M
authors.initials: JM
authors.lastname: Hunsballe
authors.forename: J C
authors.initials: JC
authors.lastname: Djurhuus
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use*; D014549:Urinary Incontinence / Q000188:drug therapy* / Q000503:physiopathology; D014551:Urinary Tract / Q000294:innervation / Q000503:physiopathology
chemical_list: D000929:Antidepressive Agents, Tricyclic; D007099:Imipramine