title: Intrathecal baclofen for generalized dystonia: a case report.
abstract: Dystonia is an abnormal movement characterized by sustained muscle contractions, frequently causing twisting and repetitive movements or abnormal postures. Primary generalized dystonia usually evolves to a debilitating condition, often unresponsive to oral pharmacologic regimens or physical rehabilitation. We present the case of a patient with idiopathic adult-onset generalized dystonia who was recalcitrant to oral therapies. This patient was treated with intrathecal baclofen therapy and responded dramatically with improved functional abilities, resolution of chronic pain, and an improved rating on the dystonia scale.
authors.affiliation: Department of Physical Medicine and Rehabilitation, Southern California Permanente Medical Group, San Diego, CA, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Jaffe
authors.forename: L J
authors.initials: LJ
authors.lastname: Nienstedt
mesh_terms: D000368:Aged; D001418:Baclofen / Q000627:therapeutic use*; D004421:Dystonia / Q000188:drug therapy* / Q000534:rehabilitation; D018755:GABA Agonists / Q000627:therapeutic use*; D006801:Humans; D015918:Infusion Pumps, Implantable; D007278:Injections, Spinal; D008297:Male; D009125:Muscle Relaxants, Central / Q000627:therapeutic use*
chemical_list: D018755:GABA Agonists; D009125:Muscle Relaxants, Central; D001418:Baclofen