[Role of the GABA-ergic and adrenergic system in transmission and modulation of pain and possibilities of pharmacologic control].
The dorsal horn of the spinal cord contains many transmitters and receptors involving in pain transmission and modulation. Monoamines and gamma-aminobutyric acid (GABA) play a key role in the modulation at level of dorsal horn (DH) of the spinal cord, the site of primary processing of afferent nociceptive information. Agents that enhance the action of GABA at the GABAA receptors can produce antinociception. For example intrathecal administration of benzodiazepines increases pain threshold in various models of pain. There is also substantial evidence for robust antinociceptive properties of spinal administration of clonidine and other alpha 2-agonists.
Dolezal
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Ustav farmakologie 3. LF UK, Praha. Tomas.Dolezal@lf3.cuni.cz
D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology*; D006801:Humans; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology*; D017288:Pain Threshold / Q000187:drug effects; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D058647:Adrenergic alpha-2 Receptor Agonists; D000316:Adrenergic alpha-Agonists; D018377:Neurotransmitter Agents; D018341:Receptors, Adrenergic, alpha-2; D001569:Benzodiazepines; D005680:gamma-Aminobutyric Acid