Synthesis of a new bisphosphonic acid ligand (SEDP) and preparation of a (188)Re-(Sn)SEDP bone seeking radiotracer.
The new bisphosphonate ligand SEDP (2-sulfonato-1,1-ethylidene bisphosphonic acid) has been synthesized and characterized, including the determination of the protonation constants, and used to form (188)Re-(Sn)SEDP from Na(188)ReO4. The title compound (188)Re-(Sn)SEDP shows slightly greater bone uptake and less kidney uptake than (188)Re-(Sn)HEDP in rat biodistribution studies.
Lisic
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EC
Chemistry Department, Tennessee Technological University, Box 5055, Cookeville, TN 38501-5055, USA. edlisic@tntech.edu
Phillips
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M
Ensor
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D
Nash
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KL
Beets
A
A
Knapp
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FF
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004164:Diphosphonates; D005260:Female; D006863:Hydrogen-Ion Concentration; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D063065:Organophosphonates / Q000138:chemical synthesis*; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000493:pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
C434766:2-sulfonato-1,1-ethylidene bisphosphonic acid; D004164:Diphosphonates; D008024:Ligands; D063065:Organophosphonates; D019275:Radiopharmaceuticals