Nerve growth factor and neurotrophin-3 promote chemotaxis of mouse macrophages in vitro.
Microchemotaxis chambers were used to explore macrophage chemotaxis in response to the neurotrophins, nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3). Both NGF and NT-3, but not BDNF, promoted macrophage chemotaxis that was receptor mediated and dependent on protein phosphorylation. These in vitro observations point to novel roles for neurotrophins that are present in nerve prior to and immediately after injury.
Kobayashi
H
H
Department of Pathology 0612, School of Medicine, University of California, San Diego, La Jolla, CA 92093-0612, USA.
Mizisin
A P
AP
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor / Q000494:pharmacology; D002478:Cells, Cultured; D002633:Chemotaxis / Q000187:drug effects*; D005260:Female; D008264:Macrophages / Q000187:drug effects* / Q000502:physiology*; D051379:Mice; D020932:Nerve Growth Factor / Q000494:pharmacology*; D020933:Neurotrophin 3 / Q000494:pharmacology*
D019208:Brain-Derived Neurotrophic Factor; D020933:Neurotrophin 3; D020932:Nerve Growth Factor