title: Palpable asymmetrical thickening of the breast: a clinical, radiological and pathological study.
abstract: While management protocols for a discrete palpable breast lump are standardized in most centres, the approach to an area of palpable asymmetrical thickening in the breast has seldom been addressed. A diagnostic algorithm for palpable asymmetrical thickening of the breast was prospectively evaluated in 116 Oriental women, followed by a retrospective review of their mammograms and histology specimens. Most women (86%) were pre-menopausal and 82% complained of a lump. The thickening eventually resolved spontaneously in 93 (80%) women. None of these 93 women developed cancer at a median follow-up of 41 months. A total of 9 (7.8%) cancers were found in the series of 116 women, including two with a lobular component. The occurrence of cancer was more likely when the woman was older than 43 years or when the thickening was marked (p<0.04). Mammographic review showed correlation of the palpable thickening with localized increase in breast tissue density and/or microcalcifications in 18% of cases. Histology review suggested fibrosis as an explanation for the clinical presentation. Although most cases of thickening tend to resolve with time, a significant number of cancers present in this way. A diagnostic approach with early and liberal imaging and biopsy for high risk women is required.
authors.affiliation: Department of Surgery, Queen Mary Hospital, Institute of Pathology, Sai Ying Pun, Department of Health, Hong Kong.
authors.forename: K L
authors.initials: KL
authors.lastname: Cheung
authors.forename: L W
authors.initials: LW
authors.lastname: Ho
authors.forename: E Y
authors.initials: EY
authors.lastname: Leung
authors.forename: U S
authors.initials: US
authors.lastname: Khoo
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000465:Algorithms; D001707:Biopsy, Needle; D001941:Breast Diseases / Q000175:diagnosis* / Q000209:etiology; D001943:Breast Neoplasms / Q000175:diagnosis / Q000209:etiology; D002114:Calcinosis / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005355:Fibrosis; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D017697:Premenopause; D011446:Prospective Studies; D012075:Remission, Spontaneous; D012189:Retrospective Studies; D012307:Risk Factors