The uniqueness of being a neurotrophin receptor.
Neurotrophins rely on Trk tyrosine kinase and p75 receptors for signal transduction. Recently, other roles for these receptors have been identified. Many questions have been raised about the mechanism by which these receptors mediate diverse cellular functions. Studies indicate a great deal of neurotrophin signaling specificity may stem from ligand-receptor selectivity and intracellular protein recruitment.
Lee
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Weill Medical College of Cornell University Medical College, New York, New York 10021, USA.
Kim
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Khursigara
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Chao
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D000818:Animals; D015703:Antigens, CD / Q000187:drug effects / Q000502:physiology*; D000951:Antigens, Neoplasm; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology; D002452:Cell Count; D004268:DNA-Binding Proteins / Q000502:physiology; D006801:Humans; D008024:Ligands; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000502:physiology; D009363:Neoplasm Proteins; D009414:Nerve Growth Factors / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D010750:Phosphoproteins; D017475:Receptors, Nerve Growth Factor / Q000145:classification / Q000187:drug effects / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor / Q000187:drug effects / Q000502:physiology*; D047889:Receptors, Tumor Necrosis Factor, Type II; D012583:Schwann Cells / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D004268:DNA-Binding Proteins; C418610:Kidins220 protein, rat; D008024:Ligands; C120897:MAGED1 protein, human; D046911:Macromolecular Substances; C486542:Maged1 protein, rat; D008565:Membrane Proteins; D009363:Neoplasm Proteins; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D017475:Receptors, Nerve Growth Factor; D018124:Receptors, Tumor Necrosis Factor; D047889:Receptors, Tumor Necrosis Factor, Type II; D014409:Tumor Necrosis Factor-alpha