Mechanisms of Ca(2+)-dependent transcription.
Ca(2+) has a central role in coupling synaptic activity and transcriptional responses. Recent studies have focused on Ca(2+)-dependent nuclear mechanisms that bring to the nucleosomal level cascades of events initiated in the submembranous space at the synapse. In addition, a new Ca(2+)-dependent interaction between a calcium sensor and DNA has been shown to regulate transcription directly.
Mellström
B
B
Departmento Biología Molecular y Celular, Centro Nacional de Biotecnología, CNB, CSIC Campus de Cantoblanco, 28049, Madrid, Spain.
Naranjo
J R
JR
D000818:Animals; D050882:CREB-Binding Protein; D019703:Calcineurin / Q000502:physiology; D002118:Calcium / Q000502:physiology; D020013:Calcium Signaling / Q000502:physiology*; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology; D006657:Histones / Q000378:metabolism; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D050778:NFATC Transcription Factors; D009419:Nerve Tissue Proteins / Q000502:physiology; D009687:Nuclear Proteins / Q000502:physiology; D009707:Nucleosomes / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D021381:Protein Transport; D019893:Ribosomal Protein S6 Kinases / Q000502:physiology; D013569:Synapses / Q000502:physiology*; D009435:Synaptic Transmission / Q000502:physiology; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic / Q000502:physiology*
D004268:DNA-Binding Proteins; D006657:Histones; D050778:NFATC Transcription Factors; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D009707:Nucleosomes; D010716:Phosphatidylinositols; D015534:Trans-Activators; D014157:Transcription Factors; D050882:CREB-Binding Protein; C494363:CREBBP protein, human; C494364:Crebbp protein, mouse; D019893:Ribosomal Protein S6 Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D019703:Calcineurin; D002118:Calcium