title: Donovanosis: an update.
abstract: Donovanosis has been ignored for many years until recently. The condition still has a limited geographical distribution. A significant epidemic of donovanosis has been identified in KwaZulu/Natal, South Africa where it may be a risk factor for acquiring HIV in men. After a gap of more than 30 years, the organism was cultured by researchers in Durban, South Africa and Darwin, Australia. Polymerase chain reaction (PCR) techniques for donovanosis were developed soon after, most recently using a colorimetric detection system. Similarities between the causative organism, Calymmatobacterium granulomatis and Klebsiella spp. were confirmed. A proposal that the organism be reclassified under the genus Klebsiella has been put forward. Azithromycin has been confirmed as the drug of choice but is yet to be accepted universally because of cost issues. Treatment in patients with significant HIV induced immune deficiency may need to be prolonged. A donovanosis eradication programme is underway amongst the aboriginal community in Australia. Elsewhere, management through current syndromic guidelines for genital ulcers are yet to be validated in areas where donovanosis is endemic. PCR testing should enable further recognition of donovanosis and lead to more concerted efforts in disease control and possible eradication.
authors.affiliation: Pasteur Suite, Ealing Hospital, Uxbridge Road, London UB1 3HW, UK.
authors.forename: N
authors.initials: N
authors.lastname: O'Farrell
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001315:Australia / Q000453:epidemiology; D017963:Azithromycin / Q000627:therapeutic use; D002157:Calymmatobacterium / Q000145:classification; D003140:Communicable Disease Control; D005260:Female; D006100:Granuloma Inguinale / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D015658:HIV Infections / Q000517:prevention & control; D006801:Humans; D007709:Klebsiella / Q000145:classification; D008297:Male; D016133:Polymerase Chain Reaction; D012307:Risk Factors; D013019:South Africa / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D017963:Azithromycin