title: No association between serotonin 2A receptor gene variants and personality traits.
abstract: Among theories of biological underpinnings to personality traits, different mechanisms of the serotonergic system are perhaps the most common factors suggested to influence individual differences in personality traits. We have investigated two frequent variants in the serotonin 2A receptor gene (5-HT2A) and personality traits. Healthy Swedish subjects (n = 304) were assessed with the Karolinska Scales of Personality (KSP) inventory. After correction for multiple testing, no significant differences were found. We conclude that the investigated 5-HT2A gene variants do not significantly influence personality as assessed by the KSP in the present population.
authors.affiliation: Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden. erikj@ks.se
authors.forename: E G
authors.initials: EG
authors.lastname: Jönsson
authors.forename: M M
authors.initials: MM
authors.lastname: Nöthen
authors.forename: J P
authors.initials: JP
authors.lastname: Gustavsson
authors.forename: C
authors.initials: C
authors.lastname: Berggård
authors.forename: R
authors.initials: R
authors.lastname: Bunzel
authors.forename: K
authors.initials: K
authors.lastname: Forslund
authors.forename: G
authors.initials: G
authors.lastname: Rylander
authors.forename: M
authors.initials: M
authors.lastname: Mattila-Evenden
authors.forename: P
authors.initials: P
authors.lastname: Propping
authors.forename: M
authors.initials: M
authors.lastname: Asberg
authors.forename: G
authors.initials: G
authors.lastname: Sedvall
mesh_terms: D000328:Adult; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D010551:Personality / Q000235:genetics; D010564:Personnel, Hospital; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D013334:Students; D011795:Surveys and Questionnaires
chemical_list: D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin