Evaluation of mutagenic activity of several antimalarial extracts from Eupatorium inulaefolium.
Eupatorium inulaefolium is used as an antimalarial agent by traditional healers of the Tumaco region (Nariño-Colombia). Several extracts of this plant have been tested by our laboratory and in vitro antimalarial activity against the FCB-2 strain of Plasmodium falciparum has been confirmed. For this reason, the mutagenic effect of the methanol, dichloromethane, and hexane extracts of Eupatorium inulaefolium (number 83377 university of Antioquia herbarium) were evaluated using the Ames test. None of the extracts evaluated had mutagenic effects on TA-98 or TA-100 strains of Salmonella typhimurium.
Pabón
A
A
Malaria Group, University of Antioquia, Medellín, Colombia.
Lopera
T
T
Carmona
J
J
Blair
S
S
D000818:Animals; D000962:Antimalarials / Q000633:toxicity*; D020137:Base Pair Mismatch / Q000187:drug effects; D004269:DNA, Bacterial / Q000187:drug effects / Q000235:genetics; D016368:Frameshift Mutation / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D012997:Solvents; D013347:Subcellular Fractions / Q000187:drug effects / Q000201:enzymology
D000962:Antimalarials; D004269:DNA, Bacterial; D009153:Mutagens; D010936:Plant Extracts; D012997:Solvents