Crosstalk and considerations in endocrine disruptor research.
The presence of endocrine disrupting chemicals in the environment has prompted action on several fronts to assess the potential health risks of these compounds. To fully understand the mechanisms behind the observed endocrine disruption, crosstalk and other factors should be considered. In this article we will discuss how crosstalk modulates estrogen action in several common assays and how this and other considerations appear to have been overlooked. In addition, a paradigm shift from theoretical linear response pathways to interaction maps should aid in the understanding and analysis of endocrine disruption.
Lackey
B R
BR
Department of Animal and Veterinary Science, Endocrine Physiology Laboratory, Clemson University, Clemson, South Carolina, USA. blackey@clemson.edu
Gray
S L
SL
Henricks
D M
DM
D000818:Animals; D001692:Biological Transport; D002455:Cell Division; D004702:Endocrine Glands / Q000187:drug effects* / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism / Q000502:physiology; D005260:Female; D017930:Genes, Reporter; D051379:Mice; D051381:Rats; D020239:Receptor Cross-Talk; D011960:Receptors, Estrogen / Q000502:physiology; D014599:Uterus / Q000187:drug effects / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen