Gastric emptying and electrogastrography in patients on CAPD.
OBJECTIVE
To evaluate if impaired gastric emptying of digestible solids can explain the disturbed eating behavior in continuous ambulatory peritoneal dialysis (CAPD) patients, and if predialytic and dialytic (CAPD and hemodialysis) patients with impaired gastric emptying have a higher prevalence of electrogastrographic (EGG) abnormalities.


METHODS
Cross-sectional study. After ingestion of a 99mTc-labeled test meal, anterior and posterior 1-minute scintigraphic acquisitions were collected every 5 minutes during the first 50 minutes and thereafter every 10 minutes until 2 hours had elapsed. Simultaneously, cutaneous EGG recorded gastric myoelectric activity.


METHODS
The Division of Nephrology and the Department of Nuclear Medicine at the same academic teaching hospital.


METHODS
Thirty outpatients participated in both the gastric emptying and the EGG studies. Dialysis patients should have been on dialysis for more than 3 months. For comparison, 160 healthy control subjects participated in the gastric emptying study.


METHODS
The following parameters were used to describe gastric emptying: lag phase 90%, half-emptying time (T50), gastric retention at 90 and 120 minutes (Ret 90/120) and gastric emptying rate (GER, %/min). Electrogastrographic measurements were expressed as percentages of normal slow waves [2.4-3.6 cycles/min (cpm)], bradygastria (1.5-2.4 cpm), and tachygastria (3.6-10 cpm).


RESULTS
T50 was prolonged, Ret 90 and Ret 120 were higher, and GER was slower in male CAPD patients compared to male controls. No significant differences were found in postprandial EGG.


CONCLUSIONS
Gastric emptying is impaired in male non-diabetic CAPD patients. However, abnormalities in postprandial EGG cannot explain this finding.
Fernström
A
A
Department of Internal Medicine, Karolinska Hospital, Stockholm, Sweden.
Hylander
B
B
Grybäck
P
P
Jacobsson
H
H
Hellström
P M
PM
D000328:Adult; D000368:Aged; D003430:Cross-Sectional Studies; D005247:Feeding Behavior; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology* / Q000628:therapy; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D011877:Radionuclide Imaging; D006435:Renal Dialysis; D012737:Sex Factors; D013270:Stomach / Q000000981:diagnostic imaging