Autoantibodies to beta-amyloid and neurotransmitters in patients with Alzheimer's disease and senile dementia of the Alzheimer type.
The content of autoantibodies to beta-amyloid protein Abeta(1-42), its neurotoxic fragment Abeta(25-35), and neurotransmitters were studied in the blood of patients with presenile Alzheimer's disease and senile dementia of the Alzheimer type. Significant differences in the relative content of autoantibodies to Abeta(1-42)and autoantibodies to biogenic amines were demonstrated. These results can be used for the development of a biochemical method for differential diagnosis of Alzheimer dementias.
Myagkova
M A
MA
Laboratory of Neurochemistry, Institute of Physiologically Active Substances, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia.
Gavrilova
S I
SI
Lermontova
N N
NN
Kalyn
Y B
YB
Selezneva
N D
ND
Zharikov
G A
GA
Kolykhalov
I V
IV
Abramenko
T V
TV
Serkova
T P
TP
Bachurin
S O
SO
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000145:classification / Q000175:diagnosis / Q000276:immunology*; D016229:Amyloid beta-Peptides / Q000097:blood / Q000276:immunology* / Q000378:metabolism; D000704:Analysis of Variance; D001323:Autoantibodies / Q000097:blood*; D015306:Biogenic Monoamines / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008875:Middle Aged; D010446:Peptide Fragments / Q000097:blood / Q000276:immunology* / Q000378:metabolism
D016229:Amyloid beta-Peptides; D001323:Autoantibodies; D015306:Biogenic Monoamines; D010446:Peptide Fragments; C075222:amyloid beta-protein (1-42); C074636:amyloid beta-protein (25-35)