Urinary excretion of diazepam metabolites in healthy volunteers and drug users.
Urinary excretion profiles of diazepam metabolites were investigated. The subjects were healthy volunteers receiving one single 10-mg dose of diazepam or drug abusers starting a prison sentence. Urinary excretion of metabolites was analysed by immunological screening, liquid chromatography and gas chromatography-mass spectrometry. Relating the metabolite concentration to creatinine concentration in the specimens decreased sample-to-sample variations. In some cases such correction could protect a subject from erroneous accusations of a new intake.
Smith-Kielland
A
A
National Institute of Forensic Toxicology, Oslo, Norway. Anne.Smith-Kielland@labmed.uio.no
Skuterud
B
B
Olsen
K M
KM
Mørland
J
J
D000328:Adult; D014151:Anti-Anxiety Agents / Q000493:pharmacokinetics*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D003404:Creatinine / Q000652:urine; D003975:Diazepam / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D003708:Nordazepam / Q000652:urine; D010076:Oxazepam / Q000652:urine; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000652:urine*; D013693:Temazepam / Q000652:urine
D014151:Anti-Anxiety Agents; D003708:Nordazepam; D010076:Oxazepam; D003404:Creatinine; D013693:Temazepam; D003975:Diazepam