title: Test-retest reliability of DSC MRI CBV mapping in healthy volunteers.
abstract: Dynamic susceptibility contrast magnetic resonance imaging (DSC MRI) can be used to generate high resolution maps of cerebral blood volume (CBV). To determine the test-retest reliability, CBV was measured in eight volunteers on two occasions, separated by 4 weeks. The mean ratio (scan 2/scan 1) for 72 cortical regions of interest (ROIs) was 1.03, with a coefficient of variation of 14%. The correlation between the first and second scans was 0.73 (p < 0.0001; 95%). In five hand-drawn ROIs, the mean ratio was 1.08, with a coefficient of variation of 12%. The correlation between scans was 0.84 (p < 0.0001). The data presented here support the hypothesis that DSC MRI CBV mapping has acceptable test-retest reliability.
authors.affiliation: Brain Imaging Center, McLean Hospital and The Department of Psychiatry, Harvard Medical School, Belmont, MA 02478, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Henry
authors.forename: M J
authors.initials: MJ
authors.lastname: Kaufman
authors.forename: N
authors.initials: N
authors.lastname: Lange
authors.forename: M E
authors.initials: ME
authors.lastname: Schmidt
authors.forename: S
authors.initials: S
authors.lastname: Purcell
authors.forename: J
authors.initials: J
authors.lastname: Cote
authors.forename: D M
authors.initials: DM
authors.lastname: Perron-Henry
authors.forename: E
authors.initials: E
authors.lastname: Stoddard
authors.forename: B M
authors.initials: BM
authors.lastname: Cohen
authors.forename: P F
authors.initials: PF
authors.lastname: Renshaw
mesh_terms: D000328:Adult; D001810:Blood Volume; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods* / Q000592:standards*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results