The Jezierski papers: live polio vaccine development in colobus monkey cells but not chimpanzee cells in the Belgian Congo, 1952-1958.
A reading of ten relevant papers by Alexandre Jezierski provides evidence for the only attempt in Central Africa to develop a live oral polio vaccine (OPV) from growing reference wild polio strains to 210 passages in colobus monkey tissue culture, and experimental administration to about 25 humans. Chimpanzees were used as a human model, but their tissues or kidneys were absent from the passage and production line of the proposed vaccine. Thus, the implication published by Hooper that Jezierski had produced a candidate OPV that might have contained chimpanzee viruses, possibly simian immunodeficiency virus cpz or the precursor of human immunodeficiency virus-1 group M, is incorrect.
Desmyter
J
J
Rega Instituut, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium. jan.desmyter@uz.kuleuven.ac.be
Teuwen
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D000818:Animals; D002478:Cells, Cultured; D002986:Clinical Trials as Topic / Q000266:history; D003104:Colobus / Q000821:virology; D015023:Democratic Republic of the Congo; D004340:Drug Contamination; D018397:Equidae; D049673:History, 20th Century; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000821:virology*; D002679:Pan troglodytes; D017955:Poliovirus / Q000502:physiology*; D011055:Poliovirus Vaccine, Oral / Q000266:history*
D011055:Poliovirus Vaccine, Oral