Renal Transport of Urate in Humans.
The theory of the "four-component model" of urate excretion in humans is reevaluated, considering that a decrease in urate excretion induced by drugs like pyrazinamide or by endogenous compounds like lactate and ketone bodies might be a result of stimulation of urate reabsorption and not, as previously considered, of inhibition of urate secretion.
Roch-Ramel
Françoise
F
Institut de Pharmacologie et Toxicologie, Bugnon 27, CH1005 Lausanne, Switzerland.
Guisan
Barbara
B