CFTR Chloride Channels: Binding Partners and Regulatory Networks.
The cystic fibrosis gene encodes a chloride channel (CFTR) that regulates transepithelial salt and water transport. Two classes of CFTR-binding proteins appear to link the opposing cytoplasmic tails of this channel to distinct regulatory networks. Such interactions may constitute new paradigms for modulating CFTR activity in health and disease.
Naren
Anjaparavanda P.
AP
Gregory Fleming James Cystic Fibrosis Research Center and the Department of Physiology and Biophysics at the University of Alabama at Birmingham, Birmingham, Alabama 35294.
Kirk
Kevin L.
KL