Correlation between blood adenosine metabolism and sleep in humans.
Blood adenosine metabolism, including metabolites and metabolizing enzymes, was studied during the sleep period in human volunteers. Searching for significant correlations among biochemical parameters found: adenosine with state 1 of slow-wave sleep (SWS); activity of 5'-nucleotidase with state 2 of SWS; inosine and AMP with state 3-4 of SWS; and activity of 5'-nucleotidase and lactate with REM sleep. The correlations were detected in all of the subjects that presented normal hypnograms, but not in those who had fragmented sleep the night of the experiment. The data demonstrate that it is possible to obtain information of complex brain operations such as sleep by measuring biochemical parameters in blood. The results strengthen the notion of a role played by adenosine, its metabolites and metabolizing enzymes, during each of the stages that constitute the sleep process in humans.
Díaz-Muñoz
M
M
Departamentos de Biología Celular and Neurociencias, Instituto de Fisiología Celular and Departamento de Fisiología, Facultad de Medicina Universidad Nacional Autónoma de México, México.
Hernández-Muñoz
R
R
Suárez
J
J
Vidrio
S
S
Yááñez
L
L
Aguilar-Roblero
R
R
Rosenthal
L
L
Villalobos
L
L
Fernández-Cancino
F
F
Drucker-Colín
R
R
Chagoya De Sanchez
V
V
D000241:Adenosine / Q000097:blood* / Q000378:metabolism; D000328:Adult; D000704:Analysis of Variance; D002940:Circadian Rhythm / Q000502:physiology; D006801:Humans; D008297:Male; D017286:Polysomnography; D012894:Sleep Stages / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology
D000241:Adenosine