[Invasion of microorganisms in bronchial mucosa of liquidators of the Chernobyl accident consequences].
Bronchial bioptates of 97 liquidators of the Chernobyl accident consequences with chronic bronchitis and 23 patients of control nosological group as well as sputum (174 persons) and BAL (22 persons) of liquidators with chronic obstructive lung disease (COLD) were studied to define pathogenic role of automicroflora in the development of lung diseases. Such methods as electron microscopy, immunohistochemistry and microbiology were used. The revealed invasion of microorganisms occurred against the background of pathology of superficial bronchial epithelium with a decrease of HLA-DR and CD23 lymphocytes and increase of CD1c lymphocytes in lamina propria of bronchial mucosa of the liquidators. Verification of microorganisms characteristic of the upper respiratory tracts and atypical presence of Escherichia coli were found in the contents of the lower parts of broncho-pulmonary system of the liquidators. The obtained results testify to the activation of automicroflora and appearance of pathogenic microorganisms were caused by deterioration of specific and non-specific immune protection in liquidators with COLD.
Poliakova
V A
VA
Institute of Human Ecological Pathology, Kyiv.
Suchko
V A
VA
Tereshchenko
V P
VP
Bazyka
D A
DA
Golovnia
O M
OM
Rudavskaia
G A
GA
D001980:Bronchi / Q000382:microbiology*; D006801:Humans; D007150:Immunohistochemistry; D008854:Microscopy, Electron; D009092:Mucous Membrane / Q000382:microbiology*; D011210:Power Plants; D029424:Pulmonary Disease, Chronic Obstructive / Q000382:microbiology; D018788:Radioactive Hazard Release; D014455:Ukraine