title: Model systems for flavoenzyme activity. Control of flavin recognition via specific electrostatic interactions.
abstract: [structure: see text] A model system has been used to study the interactions of dipole-containing aromatic systems with oxidized and reduced flavin. Ab initio computational and experimental studies show that dipole orientation within the host is a critical determinant for recognition and redox behavior of the flavin guest.
authors.affiliation: Department of Chemistry, University of Massachusetts, Amherst, Massachusetts 01003, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Goodman
authors.forename: E C
authors.initials: EC
authors.lastname: Breinlinger
authors.forename: C M
authors.initials: CM
authors.lastname: McIntosh
authors.forename: L N
authors.initials: LN
authors.lastname: Grimaldi
authors.forename: V M
authors.initials: VM
authors.lastname: Rotello
mesh_terms: D019281:Dimerization; D005415:Flavins / Q000378:metabolism*; D008958:Models, Molecular; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D011485:Protein Binding; D055672:Static Electricity; D013816:Thermodynamics
chemical_list: D005415:Flavins; D010088:Oxidoreductases