Effectiveness of mitomycin C in reducing reformation of adhesions following surgery for restrictive strabismus.
OBJECTIVE
To evaluate the efficacy of mitomycin C in reducing reformation of adhesions following surgery for restrictive strabismus.


METHODS
Sixteen patients with restrictive strabismus resulting from trauma, retinal detachment surgery, and multiple squint surgeries were randomized to either a mitomycin group (8 patients) or a control group (8 patients). Mitomycin C (0.2 mg/mL) was applied intraoperatively for 5 minutes after release of adhesions. Range of passive ductions was scored for comparison. Postoperative follow-up ranged from 3-18 months.


RESULTS
Compared to controls, the mitomycin C group had better range of passive ductions. There were no complications related to the cornea, intraocular pressure, uveitis, or muscle disinsertion in the mitomycin C group.


CONCLUSIONS
Intraoperative application of mitomycin C (0.2 mg/mL for 5 minutes) is a safe and effective adjunct to surgery in the treatment of restrictive strabismus.
Mahindrakar
A
A
Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi.
Tandon
R
R
Menon
V
V
Sharma
P
P
Khokhar
S
S
D000293:Adolescent; D000328:Adult; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002648:Child; D004311:Double-Blind Method; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D016685:Mitomycin / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy*; D011446:Prospective Studies; D012008:Recurrence; D013285:Strabismus / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control; D016896:Treatment Outcome
D000903:Antibiotics, Antineoplastic; D016685:Mitomycin