title: Symptomatic HIV seroconverting illness is associated with more rapid neurological impairment.
abstract: OBJECTIVE
  To establish whether symptomatic seroconverting illness in HIV infected people is associated with more rapid development of neurological impairment.
  
  
  METHODS
  166 HIV infected subjects with a known date of HIV infection enrolled in a longitudinal study of neurocognitive function were stratified by whether or not they had experienced a symptomatic serconverting illness.
  
  
  RESULTS
  29 of 166 (17.5%) dated HIV seroconverters had a history of symptomatic seroconverting illness. Though baseline neurocognitive function was similar, subjects with a symptomatic seroconverting illness developed clinical neurocognitive impairment significantly more rapidly than their asymptomatic counterparts in a survival analysis model (636 v 1075 days till impaired).
  
  
  CONCLUSIONS
  Symptomatic seroconverting illness predisposes to more rapid neurocognitive impairment.
authors.affiliation: Naval Medical Center San Diego, CA, USA University of California at San Diego, CA, USA. mrwallace@nmscd.med.navy.mil
authors.forename: M R
authors.initials: MR
authors.lastname: Wallace
authors.forename: J A
authors.initials: JA
authors.lastname: Nelson
authors.forename: J A
authors.initials: JA
authors.lastname: McCutchan
authors.forename: T
authors.initials: T
authors.lastname: Wolfson
authors.forename: I
authors.initials: I
authors.lastname: Grant
mesh_terms: D015526:AIDS Dementia Complex / Q000821:virology*; D000328:Adult; D005260:Female; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D012307:Risk Factors