title: S100 beta is a more reliable tumor marker in peripheral blood for patients with newly occurred melanoma metastases compared with MIA, albumin and lactate-dehydrogenase.
abstract: Lactate-dehydroxynase (LDH) has been described as a leading blood parameter in patients with melanoma metastases. However, recent data indicates that levels of S100 as well as melanoma inhibiting activity (MIA) in peripheral blood, correlate with melanoma progression. The aim of this study was to evaluate tumor markers S100, MIA, LDH and albumin in peripheral blood of 373 melanoma patients. 284 patients presented with in-situ or UICC stage I/II, and 89 with stage III/IV (54 tumor-free, 29 with newly occurred metastases). For newly occurred metastases, sensitivity was highest for S100 in peripheral blood (0.86), followed by MIA (0.80), LDH (0.48), and albumin (0.15). Specificity for albumin (0.99) and LDH (0.98) was higher than for S100 (0.91) and MIA (0.62). This data indicate that S100 in peripheral blood as compared to MIA, LDH and albumin appears to be the most appropriate tumor marker for newly occurred melanoma metastases.
authors.affiliation: Department of Dermatology, University of Ulm, 89070 Ulm/Donau, Germany. gkraehn@aol.com
authors.forename: G
authors.initials: G
authors.lastname: Krähn
authors.forename: P
authors.initials: P
authors.lastname: Kaskel
authors.forename: S
authors.initials: S
authors.lastname: Sander
authors.forename: P J
authors.initials: PJ
authors.lastname: Waizenhöfer
authors.forename: S
authors.initials: S
authors.lastname: Wortmann
authors.forename: U
authors.initials: U
authors.lastname: Leiter
authors.forename: R U
authors.initials: RU
authors.lastname: Peter
mesh_terms: D000418:Albumins / Q000032:analysis*; D014408:Biomarkers, Tumor; D001932:Brain Neoplasms / Q000097:blood* / Q000556:secondary; D002135:Calcium-Binding Proteins / Q000097:blood*; D016326:Extracellular Matrix Proteins; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008175:Lung Neoplasms / Q000097:blood* / Q000556:secondary; D008207:Lymphatic Metastasis / Q000473:pathology; D008297:Male; D008545:Melanoma / Q000097:blood* / Q000473:pathology; D009363:Neoplasm Proteins / Q000097:blood*; D009367:Neoplasm Staging; D009414:Nerve Growth Factors / Q000097:blood*; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins
chemical_list: D000418:Albumins; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D016326:Extracellular Matrix Proteins; C090059:MIA protein, human; D009363:Neoplasm Proteins; D009414:Nerve Growth Factors; D064568:S100 Calcium Binding Protein beta Subunit; D009418:S100 Proteins; C579160:S100B protein, human; D007770:L-Lactate Dehydrogenase