Development of lung edema: interstitial fluid dynamics and molecular structure.
Pulmonary interstitium is maintained dehydrated at subatmospheric pressure (-10 cmH(2)O) through low capillary permeability, low tissue compliance, and an efficient lymphatic drainage. Enzymatic degradation of proteoglycans disrupts the endothelial basal membrane and the matrix structure, triggering the development of pulmonary edema.
Miserocchi
G
G
Department of Experimental and Environmental Medicine and Biotechnology, University of Milano-Bicocca, Milano, Italy.
Negrini
D
D
Passi
A
A
De Luca
G
G
D000818:Animals; D005109:Extracellular Matrix / Q000737:chemistry / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism*; D006801:Humans; D011654:Pulmonary Edema / Q000378:metabolism* / Q000503:physiopathology*; D020545:Respiratory Mucosa / Q000378:metabolism / Q000503:physiopathology