[Proteolytic system in lungs upon inhalation exposure to low doses of lead salts].
Changes in proteinase--antiproteinase activities in lungs as a result of short-term (for 1 week) inhalation of rats with 0.01% (CH3COO)2 Pb have wholly compensative patterns, but it have been found increased cathepsine B activity as a negative prognostic factor. Chronic (for 2 month) toxicant inhalation caused considerable activation of both trypsine and cathepsine B under decreasing alpha 1-antitrypsine and alpha 2-macroglobuline activities. Cathepsine L activity was not affected. Disorders in the proteolysis system were evaluated as desadaptation situation in lung tissue under chronic toxic influence.
Likholat
E A
EA
Ukrainian State Research Institute of Medical and Social Problems of Physical Disability, Dnipropetrovsk.
Anan'eva
T V
TV
Antoniuk
S V
SV
Lutova
N B
NB
D000818:Animals; D002401:Cathepsin B / Q000378:metabolism; D056668:Cathepsin L; D002403:Cathepsins / Q000378:metabolism; D003546:Cysteine Endopeptidases; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation; D006868:Hydrolysis; D019570:Inhalation Exposure; D007854:Lead / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051381:Rats; D012492:Salts; D014357:Trypsin / Q000378:metabolism; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D012492:Salts; D000515:alpha 1-Antitrypsin; D000511:alpha-Macroglobulins; D007854:Lead; D002403:Cathepsins; D014357:Trypsin; D003546:Cysteine Endopeptidases; D002401:Cathepsin B; D056668:Cathepsin L; C534280:Ctsl protein, rat