Burnet oration. T-cell survival and the role of cytokines.
Typical T cells are long-lived resting cells. Despite their quiescent appearance, there is increasing evidence that T cells are subjected to continuous stimulation through contact with various stimuli, notably by self peptide/MHC complexes and cytokines. These stimuli keep T cells alive and also cause intermittent entry into cell cycle.
Sprent
J
J
Department of Immunology, IMM4, The Scripps Research Institute, La Jolla, California 92037, USA. jsprent@scripps.edu
D000818:Animals; D002455:Cell Division / Q000276:immunology; D002470:Cell Survival; D016207:Cytokines / Q000378:metabolism*; D005434:Flow Cytometry; D006706:Homeostasis; D007156:Immunologic Memory / Q000502:physiology; D007378:Interleukins / Q000378:metabolism*; D008213:Lymphocyte Activation; D051379:Mice; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology*
D016207:Cytokines; D007378:Interleukins; D011948:Receptors, Antigen, T-Cell