title: [Activity of cathepsin B and cystatins in the placenta during EPH-gestosis].
abstract: Activity of cathepsin B using Bz-DL-Arg-pNA contents of SH-group by means of Ellman method, activity of cystatins against papain using casein as a substrate and contents of deoxyribonuclein acids by Burton method were determined in 64 placentas of pregnancies with EPH-gestosis and in 36 placentas of physiological pregnancies. The placentas from pregnancies with EPH-gestosis showed markedly higher activity of cathepsin B, no difference in the contents of SH-group, slightly higher activity of cystatins and they contain less deoxyribonucleic acids than the placentas from physiological pregnancies. The obtained results show that proteolytic--anti-proteolytic balance in placentas from pregnacies with EPH-gestosis is changed to the advantage of cathepsin B. This protease may in formation of structural and functional changes observed in placentas during EPH-gestosis.
authors.affiliation: Zakładu Analizy Instrumentalnej, Akademii Medycznej w Białymstoku.
authors.forename: M
authors.initials: M
authors.lastname: al-Hameri
authors.forename: W
authors.initials: W
authors.lastname: Roszkowska-Jakimiec
authors.forename: M
authors.initials: M
authors.lastname: Gacko
authors.forename: M
authors.initials: M
authors.lastname: Chlabicz
mesh_terms: D002401:Cathepsin B / Q000378:metabolism*; D015891:Cystatins / Q000378:metabolism*; D005260:Female; D006801:Humans; D010920:Placenta / Q000378:metabolism*; D011225:Pre-Eclampsia / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D015891:Cystatins; D002401:Cathepsin B