Are cannabinoid receptor knockout mice animal models for schizophrenia?
Schizophrenia is a devastating psychiatric disorder with a high prevalence worldwide. There is therefore a need for animal models allowing the development of new therapeutic interventions and reliable diagnostic tests. In the temporal domain, cannabinoid receptor gene (CB1) knockout mice exhibit behavioural alterations, which parallel symptoms in schizophrenia, cannabis intoxication and dopamine D2 activation. While a specific nucleotide homology between CB1 and D2 accounts for the pathophysiology, pre-inserted spirochaetal DNA on the polyadenylation signal of CB1 reveals the aetiology of schizophrenia. If, in analogy to thalassaemia, mutations occur within this 3' regulatory domain, the genetic expression of CB1 is disrupted and sequential information lost in time. CB1, previously unrecognized as a candidate gene, thus unifies the different aspects of schizophrenic psychosis: cannabis-induced model psychosis, disrupted information processing, spatio-temporal distortions and other psychotic symptoms, disturbed neuronal migration, schizophrenic brain disorder, familial transmission, and prenatal infection by Borrelia burgdorferi.
Fritzsche
M
M
Praxis für Innere Medizin, Adliswil, Switzerland. markus.fritzche@gmx.ch
D000818:Animals; D001483:Base Sequence; D004247:DNA; D004195:Disease Models, Animal; D051379:Mice; D018345:Mice, Knockout; D010641:Phenotype; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000235:genetics / Q000502:physiology*; D012559:Schizophrenia / Q000235:genetics / Q000503:physiopathology*
D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; D004247:DNA