title: Artificial neural network-based method of screening heart murmurs in children.
abstract: BACKGROUND
  Early recognition of heart disease is an important goal in pediatrics. Efforts in developing an inexpensive screening device that can assist in the differentiation between innocent and pathological heart murmurs have met with limited success. Artificial neural networks (ANNs) are valuable tools used in complex pattern recognition and classification tasks. The aim of the present study was to train an ANN to distinguish between innocent and pathological murmurs effectively.
  
  
  RESULTS
  Using an electronic stethoscope, heart sounds were recorded from 69 patients (37 pathological and 32 innocent murmurs). Sound samples were processed using digital signal analysis and fed into a custom ANN. With optimal settings, sensitivities and specificities of 100% were obtained on the data collected with the ANN classification system developed. For future unknowns, our results suggest the generalization would improve with better representation of all classes in the training data.
  
  
  CONCLUSIONS
  We demonstrated that ANNs show significant potential in their use as an accurate diagnostic tool for the classification of heart sound data into innocent and pathological classes. This technology offers great promise for the development of a device for high-volume screening of children for heart disease.
authors.affiliation: University of Colorado Health Sciences Center, the Children's Hospital, Denver, CO 80218, USA. degroff.curt@tchden.org
authors.forename: C G
authors.initials: CG
authors.lastname: DeGroff
authors.forename: S
authors.initials: S
authors.lastname: Bhatikar
authors.forename: J
authors.initials: J
authors.lastname: Hertzberg
authors.forename: R
authors.initials: R
authors.lastname: Shandas
authors.forename: L
authors.initials: L
authors.lastname: Valdes-Cruz
authors.forename: R L
authors.initials: RL
authors.lastname: Mahajan
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006337:Heart Murmurs / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008403:Mass Screening / Q000379:methods*; D016571:Neural Networks, Computer; D012680:Sensitivity and Specificity