Modulation of cell proliferation by heterotrimeric G protein in Arabidopsis.
The alpha subunit of a prototypical heterotrimeric GTP-binding protein (G protein), which is encoded by a single gene (GPA1) in Arabidopsis, is a modulator of plant cell proliferation. gpa1 null mutants have reduced cell division in aerial tissues throughout development. Inducible overexpression of GPA1 in Arabidopsis confers inducible ectopic cell division. GPA1 overexpression in synchronized BY-2 cells causes premature advance of the nuclear cycle and the premature appearance of a division wall. Results from loss of function and ectopic expression and activation of GPA1 indicate that this subunit is a positive modulator of cell division in plants.
Ullah
H
H
Department of Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Chen
J G
JG
Young
J C
JC
Im
K H
KH
Sussman
M R
MR
Jones
A M
AM
D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology; D000483:Alleles; D017360:Arabidopsis / Q000166:cytology* / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D029681:Arabidopsis Proteins; D048429:Cell Size; D044385:GTP-Binding Protein alpha Subunits; D017343:Genes, Plant; D017930:Genes, Reporter; D005966:Glucuronidase / Q000032:analysis / Q000235:genetics; D006160:Guanosine Triphosphate / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D007210:Indoleacetic Acids / Q000494:pharmacology; D036341:Intercellular Signaling Peptides and Proteins; D008027:Light; D020935:MAP Kinase Signaling System; D009024:Morphogenesis; D009154:Mutation; D010455:Peptides / Q000494:pharmacology; D010641:Phenotype; D018515:Plant Leaves / Q000166:cytology / Q000254:growth & development; D010947:Plants, Toxic; D021122:Protein Subunits; D011994:Recombinant Proteins / Q000378:metabolism; D015398:Signal Transduction; D014026:Nicotiana
D029681:Arabidopsis Proteins; C429765:GPA1 protein, Arabidopsis; D044385:GTP-Binding Protein alpha Subunits; D007210:Indoleacetic Acids; D036341:Intercellular Signaling Peptides and Proteins; C084070:Mas7 protein, synthetic; D010455:Peptides; D021122:Protein Subunits; D011994:Recombinant Proteins; D015084:2,4-Dichlorophenoxyacetic Acid; D006160:Guanosine Triphosphate; D005966:Glucuronidase; D020962:Heterotrimeric GTP-Binding Proteins