NMDA receptor subunits: diversity, development and disease.
N-methyl-D-aspartate receptors (NMDARs) are present at many excitatory glutamate synapses in the central nervous system and display unique properties that depend on their subunit composition. Biophysical, pharmacological and molecular methods have been used to determine the key features conferred by the various NMDAR subunits, and have helped to establish which NMDAR subtypes are present at particular synapses. Recent studies are beginning to address the functional significance of NMDAR diversity under normal and pathological conditions.
Cull-Candy
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S
Department of Pharmacology, University College London, Gower Street, WC1E 6BT, London, UK. s.cull-candy@ucl.ac.uk
Brickley
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S
Farrant
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M
D017398:Alternative Splicing; D000818:Animals; D020013:Calcium Signaling / Q000502:physiology; D004195:Disease Models, Animal; D015195:Drug Design; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D007700:Kinetics; D046911:Macromolecular Substances; D001523:Mental Disorders / Q000378:metabolism; D051379:Mice; D009419:Nerve Tissue Proteins / Q000737:chemistry* / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D009422:Nervous System Diseases / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology; D020033:Protein Isoforms / Q000502:physiology; D021122:Protein Subunits; D016194:Receptors, N-Methyl-D-Aspartate / Q000737:chemistry* / Q000145:classification / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D012559:Schizophrenia / Q000378:metabolism; D013347:Subcellular Fractions / Q000737:chemistry; D013569:Synapses / Q000378:metabolism; D009435:Synaptic Transmission / Q000187:drug effects
D018690:Excitatory Amino Acid Agonists; D018691:Excitatory Amino Acid Antagonists; D046911:Macromolecular Substances; C409466:NR1 NMDA receptor; C120997:NR2A NMDA receptor; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D021122:Protein Subunits; D016194:Receptors, N-Methyl-D-Aspartate