Molecular Mechanisms in Bile Formation.
Active canalicular secretion of bile salts and non-bile salt organic anions represents the major driving force of hepatic bile formation. The most important carriers involved have now been cloned on both the basolateral and canalicular sides of hepatocytes. Elucidation of their structure, transport properties, and regulation is an important step forward in the ultimate understanding of the molecular physiology of bile formation.
Meier
Peter J.
PJ
Division of Clinical Pharmacology and Toxicology, 1 Department of Medicine, University Hospital Zurich, CH-8091 Zurich, Switzerland.
Stieger
Bruno
B