Physiological properties of blood substitutes.
Blood substitutes (modified hemoglobin solutions, perfluorocarbon emulsions) serve as artificial oxygen carriers and are alternatives to blood transfusions. Hemoglobin solutions mimic the sigmoidal oxygen dissociation curve of natural blood. Perfluorocarbon emulsions exhibit a linear relation between PO2 and dissolved oxygen. The most advanced substances may enter medicine in few years.
Spahn
D R
DR
Institut für Anästhesiologie, UniversitätsSpital, Rämistrasse 100, CH-8091 Zürich, Switzerland.
Pasch
T
T
D000818:Animals; D001802:Blood Substitutes / Q000378:metabolism*; D006801:Humans; D010100:Oxygen / Q000378:metabolism*
D001802:Blood Substitutes; D010100:Oxygen