A thioester ligation approach to amphipathic bicyclic peptide library.
An efficient approach to synthesize an amphipathic bicyclic peptide library from unprotected peptides is demonstrated through an on-resin intramolecular thioester ligation and an off-resin DMSO-mediated disulfide formation.
Sun
Y
Y
Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing 100050, China.
Lu
G
G
Tam
J P
JP
D000595:Amino Acid Sequence; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D003500:Cyclization; D008969:Molecular Sequence Data; D010084:Oxidation-Reduction; D019151:Peptide Library; D010455:Peptides / Q000138:chemical synthesis*; D013438:Sulfhydryl Compounds / Q000737:chemistry
D001643:Bridged Bicyclo Compounds; D019151:Peptide Library; D010455:Peptides; D013438:Sulfhydryl Compounds