Autoantibodies to asialoglycoprotein receptor in chronic hepatitis C patients.
The aim of this study was to determine the incidence of autoantibodies to asialoglycoprotein receptor (ASGPR, anti-ASGPR) in chronic hepatitis C patients and to characterize the anti-ASGPR-positive and anti-ASGPR-negative patients in more detail. A total of 79 chronic hepatitis C patients were screened for the presence anti-ASGPR by ELISA. Anti-ASGPR were detected in 11 (13.9%) patients. No significant differences were found between the anti-ASGPR-positive and anti-ASGPR-negative patients in age, alanine transaminase (ALT) activity, histological findings and response and tolerance to alpha-interferon (alpha-IFN) therapy. The male predominance in the anti-ASGPR positive group was statistically significant. It was surprising that other tested autoantibodies (antinuclear autoantibodies [ANA], smooth muscle autoantibodies [SMA], type 1 liver-kidney microsome autoantibodies [LKM-1], anti-thyroglobulin and thyroid microsome autoantibodies) and increased levels of immunoglobulins A, G and/or M were observed significantly more frequently in the anti-ASGPR-negative group.
Husa
P
P
Department of Infectious Diseases, University Hospital, Brno, Czech Republic. phusa@med.muni.cz
Chalupa
P
P
Stroblová
H
H
Husová
L
L
Slesinger
P
P
Zajíc
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D037263:Asialoglycoprotein Receptor; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D019698:Hepatitis C, Chronic / Q000188:drug therapy / Q000201:enzymology / Q000276:immunology* / Q000473:pathology; D019693:Hepatitis, Autoimmune / Q000175:diagnosis / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011956:Receptors, Cell Surface / Q000276:immunology*; D011994:Recombinant Proteins; D012737:Sex Factors
D037263:Asialoglycoprotein Receptor; D001323:Autoantibodies; D015415:Biomarkers; D007370:Interferon Type I; D011956:Receptors, Cell Surface; D011994:Recombinant Proteins; D000410:Alanine Transaminase