Polymorphisms in inflammatory cytokines and Fcgamma receptors in childhood chronic immune thrombocytopenic purpura: a pilot study.
Inflammatory cytokines and low-affinity Fcgamma receptor (FcgammaR) polymorphisms were investigated in 37 children with chronic immune thrombocytopenic purpura (cITP) and 218 controls. Genotype analysis included common variants in the regulatory regions of cytokines, TNF, LTA, IL1RN, IL1A, IL1B, IL4, IL6 and IL10, and structural variants of the low affinity FcgammaRs, FCGR2A, FCGR3A and FCGR3B. Associations were observed for TNF (P = 0.0032), LTA (P = 0.019), FCGR3A (P = 0.038) and FCGR3B (P = 0.0034). Two combinations of genotypes (TNF and FCGR3A; P = 0.0003, and LTA and FCGR3B; P = 0.011) were significantly associated with cITP. These results provide preliminary evidence that variant genotypes of FcgammaRs and cytokines contribute to cITP pathogenesis.
Foster
C B
CB
Immunocompromised Host Section, Pediatric Oncology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Bethesda, MD, USA.
Zhu
S
S
Erichsen
H C
HC
Lehrnbecher
T
T
Hart
E S
ES
Choi
E
E
Stein
S
S
Smith
M W
MW
Steinberg
S M
SM
Imbach
P
P
Kühne
T
T
Chanock
S J
SJ
D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002908:Chronic Disease; D016001:Confidence Intervals; D016207:Cytokines / Q000235:genetics*; D005838:Genotype; D006801:Humans; D017572:Leukotriene A4 / Q000235:genetics; D016017:Odds Ratio; D010865:Pilot Projects; D011110:Polymorphism, Genetic; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000235:genetics* / Q000276:immunology; D017452:Receptors, IgG / Q000235:genetics*; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D016207:Cytokines; D017572:Leukotriene A4; D017452:Receptors, IgG; D014409:Tumor Necrosis Factor-alpha