Transient fetal hypothyroidism due to direct fetal administration of amiodarone for drug resistant fetal tachycardia.
Amiodarone, an anti-arrhythmic drug that contains 39% iodine, is rarely known to cause negative effects on fetal thyroid function after gestational exposure, when given orally to a pregnant woman. Two cases of fetal hypothyroidism after gestational exposure to amiodarone by direct fetal intravenous route are described here.
Vanbesien
J
J
Academisch Ziekenhuis Kinderen, Vrije Universiteit Brussel, Brussels-Jette, Belgium.
Casteels
A
A
Bougatef
A
A
De Catte
L
L
Foulon
W
W
De Bock
S
S
Smitz
J
J
De Schepper
J
J
D000328:Adult; D000638:Amiodarone / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced* / Q000188:drug therapy*; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced* / Q000188:drug therapy; D007231:Infant, Newborn; D007275:Injections, Intravenous; D008297:Male; D011247:Pregnancy; D013617:Tachycardia, Supraventricular / Q000188:drug therapy*; D013974:Thyroxine / Q000627:therapeutic use; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D000638:Amiodarone; D013974:Thyroxine