title: Children with organic growth hormone deficiency have elevated cortisol responses to stimuli.
abstract: The aim of this study was to investigate hypothalamic-pituitary-adrenal (HPA) function in children with GH deficiency. Ninety-four patients were evaluated for GH deficiency and cortisol (F) deficiency using clinical criteria and L-dopa and insulin-induced hypoglycemia stimulation tests. They were assigned to three diagnostic groups: organic GH deficient (OGHD), idiopathic GH deficient (IGHD), and not GH-deficient (NGHD). Time series, cross-sectional, regression analysis revealed statistically significantly elevated F [>828 nmol/L (30 microg/dL)] in the OGHD group vs. the NGHD group. The value for F in the IGHD group was not different from the NGHD group. This finding suggests that dysregulation of the HPA axis is present in most children with OGH deficiency and significantly less often in children with IGH deficiency or without GH deficiency. Anatomical disruption of the control pathways for the HPA axis or stress may cause the dysregulation.
authors.affiliation: Department of Biobehavioral Health, College of Health and Human Development, The Pennsylvania State University, University Park, Pennsylvania 16802, USA. jwf3@psu.edu
authors.forename: J W
authors.initials: JW
authors.lastname: Finkelstein
authors.forename: D E
authors.initials: DE
authors.lastname: Rusovici
authors.forename: E
authors.initials: E
authors.lastname: Green
authors.forename: S
authors.initials: S
authors.lastname: Foreman
authors.forename: H E
authors.initials: HE
authors.lastname: Kulin
authors.forename: M R
authors.initials: MR
authors.lastname: D'Arcangelo
authors.forename: R
authors.initials: R
authors.lastname: Kemezys
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D002648:Child; D003430:Cross-Sectional Studies; D005260:Female; D019382:Human Growth Hormone / Q000172:deficiency*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced; D007328:Insulin; D007980:Levodopa; D008297:Male; D012016:Reference Values
chemical_list: D001786:Blood Glucose; D007328:Insulin; D019382:Human Growth Hormone; D007980:Levodopa; D006854:Hydrocortisone