[Preliminary results of the treatment of high grade (T1G3) superficial tumors of the bladder with transurethral resection].
OBJECTIVE
To examine the results of monotherapy with TUR in the treatment of primary T1G3 transitional cell carcinoma (TCC).


METHODS
Thirty-two patients with primary TCC of the bladder were allocated into a surveillance program. Risk factors for progression to muscle-invasive disease were determined. Immediately, projections of disease-free and progression-free survival were calculated.


RESULTS
Five patients (15.6%) were lost in follow-up. Twenty-three (85%) had superficial recurrences. Four patients (14.8%) progressed to muscle-invasive or metastatic disease. No independent risk-factors for progression were disclosed. Median disease-free survival was 8 months. Projection of the risk of recurrence at 79 months was 84.9%. Median time to progression has not been reached yet. Projection of progression at 79 months was 46.3%.


CONCLUSIONS
The above mentioned treatment schedule is associated with very high recurrence rates. In addition, recurrences are very frequent. Nevertheless, in the medium run, projections of progression suggest that surveillance can be an alternative to other treatments in the management of T1G3 TCC of the bladder.
Páez Borda
A
A
Servicio de Urología, Hospital Universitario de Getafe, Madrid.
Luján Galán
M
M
Gómez de Vicente
J M
JM
Moreno Santurino
A
A
Abate
F
F
Berenguer Sánchez
A
A
D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014521:Urethra; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000601:surgery*; D013520:Urologic Surgical Procedures / Q000379:methods