Association between seropositivity of antibodies against hepatitis a virus and Helicobacter pylori.
Helicobacter pylori and hepatitis A virus (HAV) are documented to share common transmission routes including fecal-oral. This study examined the association between seropositivity of antibodies against H. pylori (anti-HP) and HAV (anti-HAV) via a community-based survey of 40 randomly selected kindergartens in 10 urban and 10 rural areas. Serum samples from 2,047 healthy preschool children and 104 teachers were screened for anti-HP by enzyme-linked immunosorbent assay, and for anti-HAV by microparticle enzyme immunoassay. In children, a low prevalence of anti-HAV (0.44%) was found, in contrast to a high prevalence in their teachers (78.8%); anti-HP seroprevalence was 6.4% for children and 30.8% for teachers. Anti-HAV and anti-HP seropositivities were significantly associated in teachers after adjustment for age, sex, and residential area through multiple logistic regression analysis (multivariate-adjusted odds ratio = 7.3; 95% confidence interval [CI] = 1.4-36.8, P < 0.001). Our findings suggest that HAV and H. pylori may have shared transmission routes in central Taiwan 15 years or more ago, but not any recently.
Lin
D B
DB
School of Medical Technology, and Graduate Institute of Medicine, Department of Anatomy, Chung Shan Medical and Dental College, Taichung, Taiwan, Republic of China.
Tsai
T P
TP
Yang
C C
CC
Wang
H M
HM
Nieh
W T
WT
Ling
U P
UP
Changlai
S P
SP
You
S L
SL
Ho
M S
MS
Chen
C J
CJ
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000097:blood / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology*; D006506:Hepatitis A / Q000097:blood / Q000453:epidemiology*; D006507:Hepatovirus / Q000276:immunology*; D006801:Humans; D015994:Incidence; D008297:Male; D012423:Rural Health; D016036:Seroepidemiologic Studies; D013624:Taiwan / Q000453:epidemiology; D014504:Urban Health
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral