[Toxicity study of cefmatilen hydrochloride hydrate (S-1090) (8)--Nephrotoxicity study in rabbits by single oral administration].
A nephrotoxicity study of Cefmatilen hydrochloride hydrate (S-1090) was conducted in rabbits at single oral doses of 250, 500 and 1000 mg potency/kg. All treated groups showed a decreased food consumption and a tendency for the body weight to decrease. Urinary protein and glucose were detected and slight increases of plasma creatinine and urea nitrogen were observed in the 500 mg potency/kg group. Urinary protein was also detected in the 1000 mg potency/kg group. In the histopathological examination of the kidney, tubular necrosis was observed in the 500 and 1000 mg potency/kg groups. No nephrotoxic signs were observed in the 250 mg potency/kg group. The NOAEL on the nephrotoxicity of S-1090 in rabbits was estimated to be 250 mg potency/kg.
Kato
I
I
Developmental Research Laboratories, Shionogi & Co., Ltd., 3-1-1 Futaba-cho, Toyonaka, Osaka 561-0825, Japan.
Ogawa
M
M
Ueno
M
M
Nishimura
K
K
Sato
K
K
Kii
Y
Y
Muraoka
Y
Y
Hirata
M
M
Nara
H
H
D000284:Administration, Oral; D000818:Animals; D001806:Blood Urea Nitrogen; D002511:Cephalosporins / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D006029:Glycosuria / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D009336:Necrosis; D011507:Proteinuria / Q000139:chemically induced; D011817:Rabbits
D002511:Cephalosporins; D003404:Creatinine; C419864:cefmatilen