[Effects of yinchenhao decoction on normal animals and animal models of diabetes mellitus].
OBJECTIVE
To study the effects of yinchenhao Decoction on the blood glucose level in a variety of animal models and its mechanism.


METHODS
Normal mice, rats model of ailoxan (ALX)-induced diabetes mellitus (DM), mice model of ALX-DM and rats model of dexamethasone (DX)-induced insulin resistance (IR) were used.


RESULTS
yinchenhao Decoction was able to inhibit the hyperglycemia by ALX-induced mice(P < 0.01), significantly reduce level of FBG in normal mice, ALX-DM mice and rats (P < 0.05-0.01), improve IGT and lower 2hBG (P < 0.01) after OGTT in DX-induced insulin-resistant rats.


CONCLUSIONS
The results suggest that yinchenhao Decoction possesses similar hypoglycemic action to meftormin and gliclazied.
Pan
J
J
Guangzhou Institute of Traditional Chinese Medicine & Materia Medica, Guangzhou 510130.
Han
C
C
Liu
H
H
Du
J
J
Li
A
A
D000818:Animals; D019306:Artemisia / Q000737:chemistry; D001786:Blood Glucose / Q000737:chemistry / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D004365:Drugs, Chinese Herbal; D007004:Hypoglycemic Agents