Dietary exposure to 3,3',4,4',5-pentachlorobiphenyl (PCB 126) or 2,3,7,8-tetrachlorodibenzo-p-dixon (TCDD) does not induce proliferation of squamous epithelium or osteolysis in the jaws of weanling rats.
Previous studies demonstrated that dietary exposure to 24 ppb 3,3',4,4',5-pentachlorobiphenyl (PCB 126) or 2.4 ppb 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) induced maxillary and mandibular proliferation of periodontal squamous epithelium, osteolysis of alveolar bone, and loose and displaced teeth in juvenile mink (Mustela vison). This study determined if such effects could be induced in laboratory rats. Feeding weanling male Long Evans rats 20 or 100 ppb PCB 126 or 1 or 10 ppb TCDD for up to 101 days caused a dose-dependent decrease in body weight gains but did not produce the jaw lesion observed in PCB 126- or TCDD-treated mink.
Aulerich
R J
RJ
Department of Animal Science and Institute for Environmental Toxicology, Michigan State University, East Lansing, USA.
Yamini
B
B
Bursian
S J
SJ
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D007568:Jaw / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010014:Osteolysis / Q000139:chemically induced* / Q000473:pathology; D010513:Periodontal Ligament / Q000187:drug effects* / Q000473:pathology; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000633:toxicity*; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D020318:Rats, Long-Evans
D000072317:Polychlorinated Dibenzodioxins; D011078:Polychlorinated Biphenyls; C023035:3,4,5,3',4'-pentachlorobiphenyl