Changes in haemostasis after laparoscopic surgery in gynaecology: contribution of the thrombin generation test.
Surgery induces immediate hypercoagulability by direct alteration of the vascular bed, release of procoagulant substances from the extravascular spaces and blood flow decrease, and delayed hypercoagulation in response to tissue damage which triggers inflammatory responses. Thus, the postoperative period represents a high-risk time for thrombosis. Recognition of high-risk individuals would make it possible to improve thromboembolism prevention. We studied in women undergoing laparoscopic surgery a series of markers known to be related to the thrombotic risk and confronted their results with those of a global test, the thrombin generation test (TGT) described by Hemker's group. Our results show that two groups of patients can be distinguished according to usual risk markers (PAI-1, TAT, body mass index): the higher risk group demonstrates higher initial TGT values, but also a postoperative decrease of the TGT values whose mechanisms remain to be defined.
Freyburger
G
G
Laboratoire d'Hématologie, Hôpital Pellegrin, Bordeaux, France. freyburg@quaternet.fr
Dubreuil
M
M
Audebert
A
A
Labrouche
S
S
Pistre
J C
JC
Molinari
I
I
Dubecq
F
F
Laville
C
C
Villanove
X
X
D000328:Adult; D000368:Aged; D000990:Antithrombin III; D015415:Biomarkers / Q000097:blood; D001780:Blood Coagulation Tests / Q000379:methods / Q000592:standards; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D013509:Gynecologic Surgical Procedures / Q000009:adverse effects*; D006487:Hemostasis; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000097:blood; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood; D011237:Predictive Value of Tests; D012307:Risk Factors; D013918:Thrombin Time; D019851:Thrombophilia / Q000097:blood / Q000175:diagnosis / Q000209:etiology
D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; C046193:antithrombin III-protease complex; D000990:Antithrombin III; D010447:Peptide Hydrolases