MAP-kinase signaling pathways in T cells.
The family of MAP-kinases include ERKs, p38 MAP-kinases and JNKs. Recently, the role of MAP-kinases in T lymphocytes has attracted particular interest. Genetically modified mouse models have brought insight into the specific function of each MAP-kinase pathway in T lymphocyte biology. Studies clearly show that these pathways are not redundant and that the role of each pathway depends on the T cell type and differentiation stage.
Rincón
M
M
Department of Medicine/Immunobiology Program, Given Medical Building D305, University of Vermont, 05405, Burlington, VT, USA. mrincon@zoo.uvm.edu
D000818:Animals; D006801:Humans; D020935:MAP Kinase Signaling System / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D013601:T-Lymphocytes / Q000201:enzymology* / Q000378:metabolism