Insulin-mediated blood flow and glucose uptake.
Normal aging is characterized by resistance to insulin-mediated vasodilation and glucose uptake. The mechanism or mechanisms responsible for resistance to the actions of insulin remain unclear. The majority of insulin-mediated glucose uptake occurs in skeletal muscle. It has recently been demonstrated that insulin increases skeletal muscle blood flow via an endothelium-derived, nitric oxide-dependent mechanism. The authors' investigations of the relation between skeletal muscle blood flow and insulin-mediated glucose uptake in healthy elderly and young subjects are reviewed.
Floras
J S
JS
University of Toronto and Mount Sinai Hospital, Toronto, Canada. john.floras@utoronto.ca
Meneilly
G
G
D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D004730:Endothelium, Vascular / Q000502:physiology; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000502:physiology*; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply* / Q000378:metabolism*; D009569:Nitric Oxide / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D014664:Vasodilation / Q000502:physiology
D007328:Insulin; D009569:Nitric Oxide; D005947:Glucose