title: Antituberculous activity of norfloxacin mannich bases with isatin derivatives.
abstract: Mannich bases of norfloxacin were synthesized by reacting them with formaldehyde and several isatin derivatives. The compounds were evaluated in vitro against Mycobacterium tuberculosis H37R(v) at 12.5 microg/ml in BACTEC 12B medium using the BACTEC radiometric system. Among the compounds tested, S-10 showed promising activity, with 100% inhibition at a concentration lower than 6.25 microg/ml.
authors.affiliation: Department of Pharmaceutics, Institute of Technology, Banaras Hindu University, Varanasi, India. snpande@banaras.ernet.in
authors.forename: S N
authors.initials: SN
authors.lastname: Pandeya
authors.forename: D
authors.initials: D
authors.lastname: Sriram
authors.forename: P
authors.initials: P
authors.lastname: Yogeeswari
authors.forename: S
authors.initials: S
authors.lastname: Ananthan
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D007510:Isatin / Q000138:chemical synthesis / Q000494:pharmacology*; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D009643:Norfloxacin / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D008352:Mannich Bases; D007510:Isatin; D009643:Norfloxacin