title: Thrombosis in Behcet's disease: report of a case followed by a systematic review using the methodology of evidence-based medicine.
abstract: BACKGROUND
  Behcet's disease (BD) is a rare systemic inflammatory disease of unknown aetiology with a variety of organ manifestations.
  
  
  METHODS
  A case of Behcet's disease complicated by deep vein thrombosis (DVT) and inferior vena cava thrombosis referred to our institution is reported. In addition, a structured literature search using the methodology of evidence-based medicine for the localization of venous lesions, treatment modalities, and outcome of patients with Behcet's disease and concurrent thrombosis was performed. A modified validity score was assigned by established methods.
  
  
  RESULTS
  In total, 214 citations were identified using our search strategy. Among these citations, 10 papers including a total of 32 patients (25 male, 7 female) met the inclusion criteria and were incorporated into this overview together with our patient. All studies consisted of serial case reports without control subjects. Neither localization of venous lesions, nor treatment modalities were homogeneous not allowing general recommendations.
  
  
  CONCLUSIONS
  No data are available from controlled studies regarding treatment modalities of patients presenting with Behcet's disease complicated by concurrent thrombosis. This lack of evidence implicates the need for large scale and co-ordinated registries including data on the acute treatment as well as the prevention of future thrombotic events in this clinical setting. The diagnostic criteria of the "International Study Group for Behcet's Disease" may well serve as a basis for this approach.
authors.affiliation: Medical Clinic 1, RWTH University Hospital, Aachen, Germany. p.radke@ic.ac.uk
authors.forename: P W
authors.initials: PW
authors.lastname: Radke
authors.forename: E R
authors.initials: ER
authors.lastname: Schwarz
authors.forename: H
authors.initials: H
authors.lastname: Groesdonk
authors.forename: J
authors.initials: J
authors.lastname: Graf
authors.forename: U
authors.initials: U
authors.lastname: Janssens
mesh_terms: D000328:Adult; D001528:Behcet Syndrome / Q000150:complications* / Q000175:diagnosis; D003131:Combined Modality Therapy; D019317:Evidence-Based Medicine; D005260:Female; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use; D012082:Renal Veins; D015912:Thrombolytic Therapy; D013924:Thrombophlebitis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use; D016896:Treatment Outcome; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use; D016306:Vena Cava Filters; D014682:Vena Cava, Inferior / Q000601:surgery; D020246:Venous Thrombosis / Q000188:drug therapy / Q000209:etiology* / Q000601:surgery
chemical_list: D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator