Effect of chromium supplementation on production and metabolic parameters in periparturient dairy cows.
The effect of supplemental chromium as chromium-methionine (Cr-Met) on production and metabolic parameters was investigated in 48 cows from 28 d before expected calving date through 28 d of lactation. Average body weight (BW) was 730 +/- 61 kg before treatment. Treatments were supplementation of 0, 0.03, 0.06, and 0.12 mg of Cr as Cr-Met/kg of BW(0.75). Dry matter intake increased linearly and quadratically during the prepartum and postpartum periods, respectively, and body condition score loss decreased linearly during the postpartum period with increasing Cr-Met. Increasing Cr-Met supplementation caused quadratic increases in milk, fat, and lactose yields. Treatments did not affect concentrations of blood metabolites and liver triglyceride. Serum insulin concentration and molar ratio of insulin to glucose for cows receiving Cr-Met were lower than for cows not receiving Cr-Met, but they increased quadratically with increasing Cr-Met. Glucose tolerance tests (GTT) were conducted on d 10 prepartum and d 28 postpartum. Chromium-methionine supplementation attenuated insulin sensitivity prepartum and enhanced glucose tolerance postpartum, but not prepartum. Basal insulin concentrations for cows receiving Cr-Met were higher than for cows not receiving Cr-Met during the prepartum GTT. During the postpartum GTT, peak glucose concentration and clearance rate decreased and half-life (t(1/2)) and time to reach basal concentration (T) were prolonged quadratically by increasing Cr-Met. Additionally, peak insulin concentration, area under the curve, and molar ratio of insulin to glucose were higher for cows not receiving Cr-Met than for cows receiving Cr-Met and t(1/2) and T were shortened quadratically by increasing Cr-Met.
Hayirli
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A
Department of Dairy Science, University of Wisconsin, Madison 53706-1284, USA.
Bremmer
D R
DR
Bertics
S J
SJ
Socha
M T
MT
Grummer
R R
RR
D000596:Amino Acids; D000818:Animals; D019540:Area Under Curve; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight; D002417:Cattle / Q000502:physiology*; D002857:Chromium / Q000008:administration & dosage* / Q000378:metabolism* / Q000494:pharmacology; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D005951:Glucose Tolerance Test / Q000662:veterinary; D007774:Lactation / Q000502:physiology*; D008892:Milk / Q000737:chemistry*; D009539:Nicotinic Acids; D049590:Postpartum Period / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy
D000596:Amino Acids; D009539:Nicotinic Acids; C015240:glucose tolerance factor; D002857:Chromium