title: [Cisplatin and vinorelbine therapy of previously treated advanced breast cancer (preliminary studies)].
abstract: In this work it was investigated the efficacy of second and third line chemotherapy (vinorelbine, cisplatin/carboplatin) in patients with metastases breast cancer. The twenty pre-treated women with metastases to the liver, lung, lymph nodules and subcutaneous tissue were treated the regiment including navelbine 30 mg day 1 and 5 and cisplatin 100 mg/m2 day 1 every 3 weeks. The patients had been early received CMF and/or FAC. The total response rate was 40%. The median time to progression was 8 months. The stabilisation disease was at 20% patients. The tolerance of treatment was good and the frequent complication was leucopenia (WHO 2 and 3) and thrombocytopenia (WHO 1). The women received from 6 to 10 courses.
authors.affiliation: Katedra i Zakład Onkologii AM w Lublinie.
authors.forename: L
authors.initials: L
authors.lastname: Szatkowska
authors.forename: M
authors.initials: M
authors.lastname: Mazurkiewicz
authors.forename: A
authors.initials: A
authors.lastname: Brzozowska
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D018450:Disease Progression; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006402:Hematologic Diseases / Q000139:chemically induced; D006801:Humans; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D012878:Skin Neoplasms / Q000556:secondary; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000077235:Vinorelbine
chemical_list: D014747:Vinblastine; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D000077235:Vinorelbine; D005472:Fluorouracil; D008727:Methotrexate