Cytokines and anorexia nervosa.
OBJECTIVE
Recent studies have indicated that the inflammatory cytokines could be implicated in anorexia nervosa and in its complications. To determinate the potential role of interleukins (IL-1, IL-2, IL-4, IL-6, IL-10), interferon (IFN gamma), tumor necrosis factor (TNF-alpha), and transforming growth factor (TGF-beta2) in anorexia nervosa, serum concentrations of these cytokines were measured in patients suffering from anorexia nervosa in comparison to healthy subjects.


METHODS
Twenty-nine anorexic women according to DSM-IV criteria participated in the study. The control group consisted of 20 healthy women without eating disorders, mood disorders, and immunological disorders.


RESULTS
We find that serum IL-2 and TGF-beta2 concentrations were both significantly decreased in anorexic patients, although the other cytokines did not differ significantly between the two groups.


CONCLUSIONS
Our results show that in patients with anorexia nervosa, there are lower levels of specific cytokines (especially IL-2 and TGF-beta2). These levels may reflect the combination of impaired nutrition and weight loss, therefore, the dysregulation of these cytokines may contribute in anorexia's complications. Follow-up studies should examine the effects of parameters such as starvation, psychopathologic factors, and psychoneuroendocrinological perturbation which could affect interplay between cytokines, neuropeptides, and neurotransmitters.
Corcos
M
M
Department of Psychiatry Adolescent and Young Adult Psychiatry, Institut Mutualiste Montsouris, Paris, France. maurice.corcos@imm.fr
Guilbaud
O
O
Chaouat
G
G
Cayol
V
V
Speranza
M
M
Chambry
J
J
Paterniti
S
S
Moussa
M
M
Flament
M
M
Jeammet
P
P
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000378:metabolism*; D016207:Cytokines / Q000378:metabolism*; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000097:blood; D008233:Lymphotoxin-alpha / Q000097:blood
D016207:Cytokines; D007376:Interleukin-2; D008233:Lymphotoxin-alpha