title: The designability of protein structures.
abstract: It has been noted that natural proteins adapt only a limited number of folds. Several researchers have investigated why and how nature has selected this small number of folds. Using simple models of protein folding, we demonstrate systematically that there is a "designability principle" behind nature's selection of protein folds. The designability of a structure (fold) is measured by the number of sequences that can design the structure--that is, sequences that possess the structure as their unique ground state. Structures differ drastically in terms of their designability. A small number of highly designable structures emerge with a number of associated sequences much larger than the average. These highly designable structures possess proteinlike secondary structures, motifs, and even tertiary symmetries. In addition, they are thermodynamically more stable and fold faster than other structures. These results suggest that protein structures are selected in nature because they are readily designed and stable against mutations, and that such a selection simultaneously leads to thermodynamic stability.
authors.affiliation: NEC Research Institute, 4 Independence Way, Princeton, NJ 08540, USA.
authors.forename: R
authors.initials: R
authors.lastname: Helling
authors.forename: H
authors.initials: H
authors.lastname: Li
authors.forename: R
authors.initials: R
authors.lastname: Mélin
authors.forename: J
authors.initials: J
authors.lastname: Miller
authors.forename: N
authors.initials: N
authors.lastname: Wingreen
authors.forename: C
authors.initials: C
authors.lastname: Zeng
authors.forename: C
authors.initials: C
authors.lastname: Tang
mesh_terms: D020816:Amino Acid Motifs; D003198:Computer Simulation; D006801:Humans; D008433:Mathematics; D008958:Models, Molecular; D011487:Protein Conformation; D017510:Protein Folding; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D011506:Proteins