title: Successful radiosurgical treatment of lesional epilepsy of mesial temporal origin.
abstract: We report a case of successful radiosurgical treatment of lesional epilepsy of mesial temporal origin. A patient presented with a 2-year history of medically intractable complex partial seizures associated with a mesial temporal angioma. Interictal scalp EEG and MEG showed focal epileptiform activity around the lesion. 99mTc-HMPAO-SPECT and 18F-FDG-PET demonstrated depressed blood flow and glucose metabolism in the corresponding temporal lobe. The patient underwent gamma knife radiosurgery for the causative lesion with a low marginal dose of 18 Gy. After treatment, the partial attack ceased without shrinkage of the lesion or peri-lesional parenchymal radiation injury.
authors.affiliation: Department of Neurosurgery, Graduate School of Medicine, University of Tokyo, Tokyo, Japan. hkurita-tky@umin.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Kurita
authors.forename: I
authors.initials: I
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Shin
authors.forename: K
authors.initials: K
authors.lastname: Kawai
authors.forename: M
authors.initials: M
authors.lastname: Tago
authors.forename: T
authors.initials: T
authors.lastname: Momose
authors.forename: T
authors.initials: T
authors.lastname: Kirino
mesh_terms: D000328:Adult; D001932:Brain Neoplasms / Q000150:complications / Q000601:surgery; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000209:etiology* / Q000601:surgery*; D005260:Female; D019788:Fluorodeoxyglucose F18; D006391:Hemangioma / Q000150:complications / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D015225:Magnetoencephalography; D019275:Radiopharmaceuticals; D016634:Radiosurgery / Q000379:methods*; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon; D016896:Treatment Outcome
chemical_list: D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D019690:Technetium Tc 99m Exametazime