[Study of association between the ser-9-gly polymorphism of the D3 dopaminergic receptor and schizophrenia].
Two molecular genetic studies were undertaken to investigate the association between a ser-9-gly polymorphism in the dopamine D3 receptor gene and schizophrenia. The first study analysed 141 schizophrenic patients and 189 matched controls. In addition, an haplotype relative risk study was performed using 35 trios (mother, father, affected offspring). No allelic or genotype association was found in both studies. We conclude that this D3 polymorphism is not a risk factor for schizophrenia in our sample.
Cordeiro
Q
Q
Instituto de Psiquiatria, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo.
Junqueira
R
R
Vallada
H
H
D016022:Case-Control Studies; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D005998:Glycine / Q000235:genetics*; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050637:Receptors, Dopamine D3; D012559:Schizophrenia / Q000235:genetics*; D017422:Sequence Analysis, DNA; D012694:Serine / Q000235:genetics*
C493593:DRD3 protein, human; D017448:Receptors, Dopamine D2; D050637:Receptors, Dopamine D3; D012694:Serine; D005998:Glycine