title: Temporary reversal by topotecan of marked insulin resistance in a patient with myelodysplastic syndrome: case report and possible mechanism for tumor necrosis factor alpha (TNF-alpha)-induced insulin resistance.
abstract: Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor. We report here a remarkable degree of insulin resistance in a patient with adult respiratory distress syndrome and myelodysplasia.
authors.affiliation: Eastern Idaho Regional Medical Center, Idaho Falls, Idaho, USA.
authors.forename: M O
authors.initials: MO
authors.lastname: Huntington
authors.forename: K E
authors.initials: KE
authors.lastname: Krell
authors.forename: W E
authors.initials: WE
authors.lastname: Armour
authors.forename: J E
authors.initials: JE
authors.lastname: Liljenquist
mesh_terms: D000368:Aged; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009190:Myelodysplastic Syndromes / Q000378:metabolism*; D013997:Time Factors; D019772:Topotecan / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000502:physiology*
chemical_list: D004791:Enzyme Inhibitors; D014409:Tumor Necrosis Factor-alpha; D019772:Topotecan