title: Fibrin sealant: a novel method of fixation for an implantable ultrasonic microDoppler probe.
abstract: While free tissue transfer affords the reconstructive microvascular surgeon the ability to provide coverage for complex wounds, the postoperative monitoring of these flaps continues to evolve. The most recent advance has been the development of an implantable microDoppler probe to provide an early warning signal for vascular obstruction. The current system relies on the use of a silicone cuff to secure a 1-mm probe to the outflow vein. The release force to remove the probe from the cuff is reported to be 1/10 of a pound (45 g). A disadvantage of this system is the need for a circumferential, relatively inelastic device around the vein. Should the cuff be too tightly secured to the vein, the potential for outflow obstruction exists. Moreover, if the probe is not well-approximated to the vein, no signal is produced. Finally, the fact that a foreign body remains in the wound after completion of the monitoring period remains a concern. The authors have investigated a new method to adhere the probe, using a commercially available fibrin sealant. The use of this biocompatible substance has the potential to obviate the need for the current method of fixation, and the associated concerns.
authors.affiliation: Department of Plastic Surgery, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Bill
authors.forename: P A
authors.initials: PA
authors.lastname: Foresman
authors.forename: G T
authors.initials: GT
authors.lastname: Rodeheaver
authors.forename: D B
authors.initials: DB
authors.lastname: Drake
mesh_terms: D000818:Animals; D004784:Environmental Monitoring / Q000295:instrumentation*; D015718:Fibrin Tissue Adhesive / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013524:Surgical Flaps; D014014:Tissue Adhesives / Q000494:pharmacology*; D018608:Ultrasonography, Doppler / Q000295:instrumentation*; D014680:Veins / Q000502:physiology
chemical_list: D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives