Total synthesis of (-)-callystatin A.
An effective total synthesis of (-)-callystatin A (1), member of the leptomycin family of antibiotics, has been achieved. The synthesis features Evans extended aldol methodology to construct the northern polypropionate subunit and two separate Julia olefinations to assemble the conjugated dienes. The total synthesis proceeded in 2.3% overall yield with the longest linear sequence of 15 steps.
Smith
A B
AB
Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA. smithab@sas.upenn.edu
Brandt
B M
BM
D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D018360:Crystallography, X-Ray; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis*; D007202:Indicators and Reagents
D000970:Antineoplastic Agents; D005231:Fatty Acids, Unsaturated; D007202:Indicators and Reagents; C421091:callystatin A