Catalytic asymmetric vinylation of ketone enolates.
[see reaction]. A protocol for the catalytic asymmetric vinylation of ketone enolates has been developed. Key to the success of this process was the development of new electron-rich chiral monodentate ligands.
Chieffi
A
A
Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA.
Kamikawa
K
K
Ahman
J
J
Fox
J M
JM
Buchwald
S L
SL
D002384:Catalysis; D007659:Ketones / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry*
D007659:Ketones; D014753:Vinyl Compounds