title: [Increased consumption of drugs among the elderly results in greater risk of problems].
abstract: With aging comes an increasing prevalence of diseases and symptoms that frequently require pharmaceutical treatment. However, aging also brings about bodily changes that result in increased effects and prolonged action of many drugs. Multiple drug use--often termed polypharmacy--seen in many elderly individuals, is the most important risk factor for adverse drug reactions (ADR) and increases the risk of drug interactions and poor compliance. ADR's are responsible for about 10% of all hospital admissions of elderly patients. The drugs most commonly involved are cardiovascular, psychotropics and anti-inflammatory agents. Many of these ADR's are dose-dependent and preventable. Drug use has increased over the last few years, largely thanks to the availability of new and effective agents. This calls for increased vigilance and prudence in prescribing for the elderly.
authors.affiliation: Neurotec, Karolinska institutet och Stockholms läns äldrecentrum. johan.fastbom@neurotec.ki.se
authors.forename: J
authors.initials: J
authors.lastname: Fastbom
mesh_terms: D000368:Aged; D000375:Aging / Q000378:metabolism / Q000502:physiology / Q000523:psychology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000009:adverse effects; D003072:Cognition Disorders / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D011307:Drug Prescriptions; D004363:Drug Utilization; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D019338:Polypharmacy; D011619:Psychotropic Drugs / Q000008:administration & dosage / Q000009:adverse effects; D012307:Risk Factors
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002317:Cardiovascular Agents; D011619:Psychotropic Drugs