Efficient scavenging of Ph3P and Ph3P=O with high-loading merrifield resin.
[see reaction]. A simple, highly effective method for removing triphenylphosphine and/or triphenylphosphine oxide from reaction mixtures is described. Commercially available high-loading chloromethylated polystyrene 1, modified in situ with NaI, acts as a scavenger resin. Several coupling reactions catalyzed by Pd(0) or Ni(0) which require the removal of triphenylphosphine are tested.
Lipshutz
B H
BH
Department of Chemistry and Biochemistry, University of California, Santa Barbara, California 93106, USA. lipshutz@chem.ucsb.edu
Blomgren
P A
PA
D002384:Catalysis; D009532:Nickel / Q000737:chemistry; D009943:Organophosphorus Compounds / Q000737:chemistry*; D010165:Palladium / Q000737:chemistry; D012116:Resins, Plant; D012974:Sodium Iodide / Q000737:chemistry
D009943:Organophosphorus Compounds; D012116:Resins, Plant; C061896:triphenylphosphine; D010165:Palladium; D009532:Nickel; D012974:Sodium Iodide; C063888:triphenylphosphine oxide