The risk of pregnancy-related venous thromboembolism in women who are homozygous for factor V Leiden.
The risk of venous thromboembolism (VTE) is increased in pregnancy and during the post-partum period. The absolute risk for pregnancy-related VTE in heterozygous women with the factor V Leiden mutation is approximately 2%, but studies on this risk for homozygous women show conflicting results. In a retrospective family study, we found that the risk of pregnancy-related VTE in women with a symptomatic first-degree relative was 17% per pregnancy (95%CI 4.7-37.4). Anticoagulant prophylaxis during the post-partum period appears to be indicated in asymptomatic homozygous women from symptomatic kindred, whereas this could be decided on an individual basis during pregnancy.
Middeldorp
S
S
Department of Vascular Medicine, Academic Medical Centre, Amsterdam, The Netherlands. S.Middeldorp@amc.uva.nl
Libourel
E J
EJ
Hamulyák
K
K
Van der Meer
J
J
Büller
H R
HR
D005165:Factor V / Q000235:genetics*; D005260:Female; D006720:Homozygote; D006801:Humans; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D011644:Puerperal Disorders / Q000097:blood; D012189:Retrospective Studies; D012306:Risk; D020246:Venous Thrombosis / Q000097:blood*
C095381:factor V Leiden; D005165:Factor V