title: Tandem conjugate reduction-aldol cyclization using Stryker's reagent.
abstract: [see reaction]. Conjugate reduction by Stryker's reagent to form copper enolates, followed by intramolecular aldol cyclization, successfully generated five- and six-membered carbocycles in one pot efficiently. This tandem reaction is generally diastereoselective and provides good yields of the beta-hydroxyketones without any dehydration at low temperatures.
authors.affiliation: Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. pchiu@hkucc.hku.hk
authors.forename: P
authors.initials: P
authors.lastname: Chiu
authors.forename: C P
authors.initials: CP
authors.lastname: Szeto
authors.forename: Z
authors.initials: Z
authors.lastname: Geng
authors.forename: K F
authors.initials: KF
authors.lastname: Cheng