title: Exuberant Ca(2+) Signaling in Neutrophils: A Cause for Concern.
abstract: Under inflammatory conditions after burn/trauma injuries, circulating neutrophils are frequently hyperactive, contributing to excessive superoxide production and related tissue damage. Although normal neutrophil activation is cooperatively controlled by Ca(2+)-independent and Ca(2+)-linked signaling pathways, exuberant Ca(2+)-linked signaling appears to cause neutrophil hyperactivation in the injury conditions.
authors.affiliation: Departments of Physiology and Surgery and the Burn and Shock Trauma Institute, Loyola University Medical Center, Maywood, IL 60153.
authors.forename: Mohammed M.
authors.initials: MM
authors.lastname: Sayeed