Application of low copy number DNA profiling.
Low copy number (LCN) DNA profiling is a technique sensitive enough to analyze just a few cells. When this kind of analysis is carried out, special considerations are needed to interpret the results. In particular, it is important to consider the implications of allele dropout and the possibility of contamination from a laboratory source. A rationale for interpreting LCN DNA is described.
Gill
P
P
Forensic Science Service, Trident Court, 2960 Solihull Parkway, Birmingham B37 7YN, UK. 101642.3373@compuserve.com
D016172:DNA Fingerprinting / Q000379:methods*; D005554:Forensic Medicine / Q000379:methods*; D005784:Gene Amplification; D006801:Humans; D021141:Nucleic Acid Amplification Techniques; D016133:Polymerase Chain Reaction / Q000379:methods*; D012680:Sensitivity and Specificity; D020080:Tandem Repeat Sequences