title: The Brix domain protein family -- a key to the ribosomal biogenesis pathway?
abstract: Six (one archaean and five eukaryotic) protein families have similar domain architecture that includes a central globular Brix domain, and optional N- and obligatory C-terminal segments, both with charged low-complexity regions. Biological data for some proteins in this superfamily suggest a role in ribosome biogenesis and rRNA binding.
authors.affiliation: Research Institute of Molecular Pathology, Dr.Bohr-Gasse 7, A-1030 Vienna, Rep. Austria. Frank.Eisenhaber@nt.imp.univie.ac.at
authors.forename: F
authors.initials: F
authors.lastname: Eisenhaber
authors.forename: C
authors.initials: C
authors.lastname: Wechselberger
authors.forename: G
authors.initials: G
authors.lastname: Kreil
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D008969:Molecular Sequence Data; D017434:Protein Structure, Tertiary; D012270:Ribosomes / Q000235:genetics / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid