The bradykinin/B1 receptor promotes angiogenesis by up-regulation of endogenous FGF-2 in endothelium via the nitric oxide synthase pathway.
Parenti
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A
Department of Pharmacology, University of Florence, 50139, Florence, Italy.
Morbidelli
L
L
Ledda
F
F
Granger
H J
HJ
Ziche
M
M
D000818:Animals; D019898:Autocrine Communication; D001920:Bradykinin / Q000494:pharmacology; D002455:Cell Division; D003315:Cornea / Q000098:blood supply; D004730:Endothelium, Vascular / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D008833:Microcirculation; D008954:Models, Biological; D018919:Neovascularization, Physiologic / Q000502:physiology*; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D011817:Rabbits; D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin / Q000378:metabolism*; D010738:Type C Phospholipases / Q000378:metabolism
D043783:Receptor, Bradykinin B1; D018002:Receptors, Bradykinin; D016222:Fibroblast Growth Factor 2; D019001:Nitric Oxide Synthase; D010738:Type C Phospholipases; D001920:Bradykinin