Different regulation of RGS2 mRNA by haloperidol and clozapine.
Expression of RGS2 mRNA was transiently up-regulated in rat striatum (25% in the medial part and 50% in the lateral part), in contrast to cingulate cortex and lateral septum, 30 min after acute treatment with haloperidol (2 mg/kg, i.p.). This effect disappeared 24 hours post-drug treatment, similar to the acute and strong up-regulation (700% at 30 min) of c-fos mRNA. RGS3, 5, 6, 8 or 9 mRNAs were not affected. Clozapine (20 mg/kg, i.p.) at an approximately equivalent dose of D2 receptor occupancy in the striatum did not significantly affect RGS and c-fos mRNAs levels. We suggest that RGS2 mRNA expression may be differently up-regulated in a region-specific manner by antipsychotics.
Robinet
E A
EA
Centre de Recherche Pierre Fabre, Department of Cellular and Molecular Biology, Castres, France.
Wurch
T
T
Pauwels
P J
PJ
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D003024:Clozapine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics; D020710:RGS Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
D014150:Antipsychotic Agents; D016760:Proto-Oncogene Proteins c-fos; D020710:RGS Proteins; D012333:RNA, Messenger; C105345:Rgs2 protein, mouse; D003024:Clozapine; D006220:Haloperidol