title: Epstein-Barr Virus and HLA-DPB1-*0301 in young adult Hodgkin's disease: evidence for inherited susceptibility to Epstein-Barr Virus in cases that are EBV(+ve).
abstract: Cases of Hodgkin's disease (HD) may be distinguished by whether they do [EBV-positive ((+ve)) cases] or do not [EBV-negative ((-ve)) cases] have evidence of EBV DNA in the Reed-Sternberg cells. Only one study has attempted to distinguish epidemiological risk factors for EBV(+ve) and EBV(-ve) HD, and none have compared inherited susceptibility. The present study involves a population-based case series of HD, diagnosed in patients between 16-24 years of age in the United Kingdom (n = 118), of whom 87% were classified by EBV status (EBV(+ve), 19, EBV(-ve), 84). History of infectious illness, EBV antibody titers, and HLA-DPB1 type have been compared in EBV(+ve) and EBV(-ve) cases. Reported infectious mononucleosis was more frequent in EBV(+ve) cases (odds ratio (OR), 5.10; 95% confidence interval (CI), 1.12-24.4). EBV antibody titers to viral capsid antigen were significantly higher in EBV(+ve) cases (P for trend = 0.02). Higher proportions of EBV(+ve) (43%) than EBV(-ve) (31%) cases typed positive for HLA-DPB1*0301, but this was not statistically significant; the association of infectious mononucleosis with EBV(+ve) cases was stronger in this HLA subgroup (OR, 17.1; 95%CI, 1.06-1177) than in other cases (OR, 1.24; 95% CI, 0.02-15.4). Although these results are based on small numbers of HD cases, they provide suggestive evidence that the etiology of EBV(+ve) HD may involve inherited susceptibility to EBV.
authors.affiliation: Department of Community Health Sciences, University of Edinburgh Medical School, Edinburgh EH8 9AG, United Kingdom.
authors.forename: F E
authors.initials: FE
authors.lastname: Alexander
authors.forename: R F
authors.initials: RF
authors.lastname: Jarrett
authors.forename: R A
authors.initials: RA
authors.lastname: Cartwright
authors.forename: A A
authors.initials: AA
authors.lastname: Armstrong
authors.forename: D A
authors.initials: DA
authors.lastname: Gokhale
authors.forename: E
authors.initials: E
authors.lastname: Kane
authors.forename: D
authors.initials: D
authors.lastname: Gray
authors.forename: D J
authors.initials: DJ
authors.lastname: Lawrence
authors.forename: G M
authors.initials: GM
authors.lastname: Taylor
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D016021:Epidemiologic Studies; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005260:Female; D020022:Genetic Predisposition to Disease; D006682:HLA-DP Antigens / Q000032:analysis*; D059868:HLA-DP beta-Chains; D004854:Herpesvirus 4, Human / Q000276:immunology / Q000472:pathogenicity*; D006689:Hodgkin Disease / Q000235:genetics / Q000276:immunology* / Q000821:virology*; D006801:Humans; D008297:Male; D012307:Risk Factors
chemical_list: D006682:HLA-DP Antigens; D059868:HLA-DP beta-Chains; C071170:HLA-DPB1 antigen