title: Changes in serum hypoxanthine levels by exercise in obese subjects.
abstract: To study on effect of obesity on changes in serum hypoxanthine with exercise, exercise stress testing with treadmill was performed on 7 obese subjects (body mass index [BMI], 30.6 +/- 3.2 kg/m(2)) and 16 healthy volunteers (BMI, 21.5 +/- 2.10 kg/m(2)). Expiratory gas analysis during exercise showed that peak Vo(2) was significantly lower in the obese group than in the control group (28.1 +/- 4.0 v 37.1 +/- 4.7 mL/kg/min; P <.001). Furthermore, the obese group had lower anaerobic threshold (AT) values (P <.005), respiratory quotient at AT (P =.003), and exercise capacity reserve (P =.002) than the control group. Baseline serum hypoxanthine levels were significantly higher in the obese group than in the control group (3.46 +/- 3.70 v 1.23 +/- 1.16 micromol/L; P <.05). Exercise induced a pronounced increase in serum hypoxanthine level in the obese group compared with the control group (10.65 +/- 6.81 v 43.86 +/- 4.56 micromol/L; P <.01). Serum levels of uric acid before and after load were also higher in the obese group than in the control group (404 +/- 43 v 302 +/- 77 micromol/L; P <.005). A pronounced increase in hypoxanthine with exercise may result in organ damage caused by free radicals, and intermittent training from mild intensity may be less hazardous for exercise treatment of obesity.
authors.affiliation: Section of Internal Medicine and Disability Prevention, Division of Medical Science, Tohoku University Graduate School, Sendai, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Saiki
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: M
authors.initials: M
authors.lastname: Kohzuki
authors.forename: M
authors.initials: M
authors.lastname: Kamimoto
authors.forename: T
authors.initials: T
authors.lastname: Yosida
mesh_terms: D000328:Adult; D015308:Anaerobic Threshold; D015992:Body Mass Index; D001835:Body Weight; D005080:Exercise Test; D006801:Humans; D019271:Hypoxanthine / Q000097:blood*; D009765:Obesity / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D014527:Uric Acid / Q000097:blood; D014938:Work Capacity Evaluation
chemical_list: D014527:Uric Acid; D019271:Hypoxanthine