Cardiac markers in the diagnosis of acute coronary syndromes.
Evolution of the role of cardiac markers has ranged from the diagnosis of acute myocardial infarction in patients with nondiagnostic electrocardiograms to prognostic risk stratification and to guide therapy. The technology to provide rapid, real time measurements by immunoassay has provided the laboratory and clinician with a range of test options. The principal changes have been the use of rapid serial marker measurements of well-recognized cardiac markers, and the development of immunoassays for the cardiac structural proteins. Measurement of cardiac troponins has generated a new diagnostic paradigm in patients with suspected acute coronary syndromes. There is now a new gold standard biochemical test for myocardial infarction. A range of interventions can be guided by troponin measurement. The use of troponin measurements is central to management of patients with suspected acute coronary syndromes. Future developments in this field will focus on the role of existing and novel markers of inflammation and ischemia.
Collinson
P O
PO
Department of Chemical Pathology, St. George's Hospital, Blackshaw Road, London SW17 0QT, England. collinsonpaul@hotmail.com
Chamberlain
L
L
D000208:Acute Disease; D015415:Biomarkers / Q000032:analysis*; D003327:Coronary Disease / Q000175:diagnosis*; D006801:Humans; D013577:Syndrome
D015415:Biomarkers