title: Relationship of gastric myoelectrical and cardiac parasympathetic activity to chemotherapy-induced nausea.
abstract: OBJECTIVE
  We evaluated (a) whether pretreatment levels of gastric tachyarrhythmia, a dysrhythmic pattern of gastric myoelectrical activity, or cardiac parasympathetic activity are associated with the development of chemotherapy-induced nausea and (b) whether chemotherapy-induced nausea is preceded by an increase in gastric tachyarrhythmia and a decrease in cardiac parasympathetic activity, as has been observed during motion sickness.
  
  
  METHODS
  Electrogastrograms and estimates of respiratory sinus arrhythmia (RSA) were obtained from cancer chemotherapy patients before treatment and for approximately 24 hours after treatment.
  
  
  RESULTS
  Higher levels of pretreatment gastric tachyarrhythmia were observed on chemotherapy sessions that were followed by posttreatment reports of nausea. Pretreatment levels of RSA, however, did not differ between chemotherapy treatments that were and were not followed by nausea. No statistically significant changes in gastric tachyarrhythmia or RSA were observed prior to first reports of nausea following chemotherapy.
  
  
  CONCLUSIONS
  In contrast to motion sickness, chemotherapy-induced nausea may not be related to an increase in dysrhythmic gastric myoelectrical activity; however, higher levels of pretreatment gastric tachyarrhythmia may be related to posttreatment reports of chemotherapy-induced nausea.
authors.affiliation: Cardiovascular Behavioral Medicine Research Program, University of Pittsburgh, Pittsburgh, PA, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Gianaros
authors.forename: R M
authors.initials: RM
authors.lastname: Stern
authors.forename: G R
authors.initials: GR
authors.lastname: Morrow
authors.forename: J T
authors.initials: JT
authors.lastname: Hickok
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000503:physiopathology; D004576:Electromyography; D004594:Electrophysiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced* / Q000503:physiopathology; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D013270:Stomach / Q000502:physiology*
chemical_list: D000970:Antineoplastic Agents