title: Effect of low-dose zearalenone exposure on luteal function, follicular activity and uterine oedema in cycling mares.
abstract: The effect of 10-day zearalenone administration starting 10 days after ovulation was studied in 6 cycling trotter mares in the summer period. After an entire oestrous cycle (Cycle 1), mares were given 7 mg purified zearalenone per os daily (1 mg/ml in ethyl alcohol) beginning on Day 10 of Cycle 2. Toxin exposure was continued until the subsequent ovulation. Luteal function and follicular activity were monitored daily by rectal palpation, ultrasonography and blood sampling for progesterone. During toxin exposure, all animals were in good physical condition. The toxin had no effect on the length of the interovulatory intervals, luteal and follicular phases. It did not influence significantly the plasma progesterone profiles (logistic curve parameters A1 to A6), the follicular activity (growth rate, maximum size of the ovulatory follicles, maximum number and the time of first increase in the number of large follicles) and the uterine oedema. It is concluded that in cyclic mares the methods used in this study could not detect any adverse effect of zearalenone (administered at a low dose similar to natural exposure) on reproduction.
authors.affiliation: Research Institute, Faculty of Veterinary Science, Szent István University, H-1400 Budapest, P.O. Box 2, Hungary. gyhuszen@univet.hu
authors.forename: J
authors.initials: J
authors.lastname: Juhász
authors.forename: P
authors.initials: P
authors.lastname: Nagy
authors.forename: M
authors.initials: M
authors.lastname: Kulcsár
authors.forename: G
authors.initials: G
authors.lastname: Szigeti
authors.forename: J
authors.initials: J
authors.lastname: Reiczigel
authors.forename: G
authors.initials: G
authors.lastname: Huszenicza
mesh_terms: D000818:Animals; D001831:Body Temperature; D003338:Corpus Luteum / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage / Q000633:toxicity*; D004971:Estrus / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006736:Horses / Q000502:physiology*; D006080:Ovarian Follicle / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D011374:Progesterone / Q000097:blood; D014463:Ultrasonography; D014591:Uterine Diseases / Q000139:chemically induced; D014599:Uterus / Q000187:drug effects*; D015025:Zearalenone / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D004968:Estrogens, Non-Steroidal; D011374:Progesterone; D015025:Zearalenone