[DNase I sensitivity of nucleus and chromatin in six different tissues of old rates].
In order to investigate the mechanism of aging, we studied the DNase I sensitivity of nucleus and chromatin in six different tissue (heart, liver, spleen, lung, kidney and brain of old and weanling wistar rats. The results showed that the DNase I digestive sensitivity levels of nucleus and chromatin in the tissue of the old rats were lower than those of the weanling rats respectively that in the old rats, the DNase I digestive sensitively in the tissue varied, the lowest sensitivity was in brain (P < 0.01); and that in the weanling rats, lowest DNase I digestive sensitivity of nucleus and chromatin was also in the brain, but the difference was not significant.
Hu
H
H
Department of Medical Biology and Cytobiology, School of Basic Medical Sciences, WCUMS, Chengdu 610041.
Xing
Y
Y
Li
X
X
Ying
Y
Y
Xiao
S
S
Zheng
X
X
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002467:Cell Nucleus / Q000201:enzymology; D002843:Chromatin / Q000201:enzymology*; D003850:Deoxyribonuclease I / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000201:enzymology; D009206:Myocardium / Q000166:cytology / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar
D002843:Chromatin; D003850:Deoxyribonuclease I