Physiological levels and action of dehydroepiandrosterone in Yucatan miniature swine.
The biological role of dehydroepiandrosterone (DHEA) and its less active sulphated conjugate DHEAS was investigated in two experiments using Yucatan miniature swine. In experiment 1, plasma levels of both DHEA(S) among males were greater than female pigs that ranged in age from 0.3 to 84 mo old (P < 0.0001). In males, DHEA(S) were related inversely to serum triglycerides; DHEA was positively related to triglycerides in females (P < 0.01). In experiment 2, four 2-yr old male pigs, used as their own control, showed a 5% decrease in body weight, 11% increase in energy expenditure, 88% increase in lipid, and 100% decrease in glucose utilization (P < 0.0001) in response to DHEA vs. placebo treatments when adjusted for body weight. Plasma DHEA(S) were not different between treatment conditions. Glucose tolerance and plasma insulin levels were not different from controls. In vivo response to norepinephrine indicated beta-adrenergic sensitivity was altered by DHEA. Present findings suggest DHEA and/or its hormone products are important in modulating energy expenditure and lipid utilization for energy in male animals. The role of DHEA in energy metabolism and the difference between sexes warrant further investigation.
Tagliaferro
A R
AR
Department of Animal and Nutritional Sciences, Human Nutrition Laboratory, University of New Hampshire, Durham, New Hampshire 03824, USA. anthonyt@cisunix.unh.edu
Ronan
A M
AM
D000276:Adjuvants, Immunologic / Q000097:blood / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose; D003687:Dehydroepiandrosterone / Q000097:blood* / Q000494:pharmacology; D019314:Dehydroepiandrosterone Sulfate / Q000097:blood / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D009765:Obesity / Q000378:metabolism; D012737:Sex Factors; D013556:Swine, Miniature; D013566:Sympathomimetics / Q000494:pharmacology; D014280:Triglycerides / Q000378:metabolism*
D000276:Adjuvants, Immunologic; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D013566:Sympathomimetics; D014280:Triglycerides; D003687:Dehydroepiandrosterone; D019314:Dehydroepiandrosterone Sulfate; D005990:Glycerol; D009638:Norepinephrine