Gastro-oesophageal reflux and duodenogastric reflux before and after eradication in Helicobacter pylori gastritis.
OBJECTIVE
Helicobacter pylori and duodenogastric reflux (DGR) are both associated with chronic gastritis, peptic ulcer and gastric cancer. The nature of their interrelationship remains unclear. H. pylori eradication has also been reported to result in new or worsening acid gastro-oesophageal reflux (GOR). The aim of this study was to investigate the relationship between GOR, DGR and H. pylori infection.


METHODS
25 patients with H. pylori gastritis underwent ambulatory 24-hour oesophageal and gastric pHmetry and gastric bilirubin monitoring before and 12 weeks after H. pylori eradication, confirmed by 14C urea breath testing (UBT). Ten healthy subjects served as a control group.


RESULTS
There were no differences between patient and control groups for gastric alkaline exposure or gastric bilirubin exposure (P> 0.25 in all categories). Oesophageal acid reflux was higher in the study group (P< 0.02). No differences were detected in oesophageal acid reflux, gastric alkaline exposure, or gastric bilirubin exposure (P = 0.35, 0.18 and 0.11, respectively) before and after eradication.


CONCLUSIONS
Acid GOR is not increased by H. pylori eradication. DGR in patients with H. pylori gastritis is similar to that in healthy, non-infected subjects. H. pylori eradication produces no change in GOR or DGR. In patients with chronic gastritis, H. pylori infection and DGR appear to be independent of each other.
Manifold
D K
DK
Department of Surgery, Guy's Hospital, London, UK. Dkmanifold@aol.com
Anggiansah
A
A
Rowe
I
I
Sanderson
J D
JD
Chinyama
C N
CN
Owen
W J
WJ
D000328:Adult; D000368:Aged; D001663:Bilirubin / Q000378:metabolism; D001944:Breath Tests / Q000379:methods; D004359:Drug Therapy, Combination; D004383:Duodenogastric Reflux / Q000150:complications / Q000175:diagnosis*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D005756:Gastritis / Q000188:drug therapy* / Q000382:microbiology; D005764:Gastroesophageal Reflux / Q000150:complications / Q000175:diagnosis*; D016481:Helicobacter Infections / Q000150:complications / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000302:isolation & purification; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D008875:Middle Aged; D016896:Treatment Outcome
D001663:Bilirubin