title: The use of functional genomics in C. elegans for studying human development and disease.
abstract: The 100 Mb Caenorhabditis elegans genome sequence is the first animal genome to be sequenced in its entirety. Many reverse-genetics tools have been developed to mine the genome sequence and to facilitate the jump between the identification of a gene sequence and the understanding of its function. Here we discuss how C. elegans can contribute to understanding of the function of genes involved in human development and disease.
authors.affiliation: The Sanger Centre, Hinxton, UK. pek@sanger.ac.uk
authors.forename: P E
authors.initials: PE
authors.lastname: Kuwabara
authors.forename: N
authors.initials: N
authors.lastname: O'Neil
mesh_terms: D000818:Animals; D017173:Caenorhabditis elegans / Q000235:genetics*; D030342:Genetic Diseases, Inborn / Q000235:genetics*; D016678:Genome; D023281:Genomics; D006128:Growth / Q000502:physiology; D006801:Humans