Tec kinases: modulators of lymphocyte signaling and development.
The Tec kinases are implicated as important components of the antigen receptor signaling required for proper lymphocyte activation and development. Recent data suggest that these kinases contribute to multiprotein complexes containing LAT and SLP-76 in T cells, and BLNK/SLP-65 in B cells, which are required for activation of PLC-gamma and downstream pathways.
Lewis
C M
CM
National Human Genome Research Institute, National Institutes of Health, 20892, Bethesda, MD, USA.
Broussard
C
C
Czar
M J
MJ
Schwartzberg
P L
PL
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology; D008214:Lymphocytes / Q000166:cytology* / Q000201:enzymology* / Q000276:immunology; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology*
C089848:Tec protein-tyrosine kinase; D011505:Protein-Tyrosine Kinases