The cytoplasmic truncated receptor tyrosine kinase ALK homodimer immortalizes and cooperates with ras in cellular transformation.
Simonitsch
I
I
Institute of Clinical Pathology, Institute of Cancer Research, University of Vienna, A-1090 Vienna, Austria.
Polgar
D
D
Hajek
M
M
Duchek
P
P
Skrzypek
B
B
Fassl
S
S
Lamprecht
A
A
Schmidt
G
G
Krupitza
G
G
Cerni
C
C
D000077548:Anaplastic Lymphoma Kinase; D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000235:genetics*; D011905:Genes, ras; D017728:Lymphoma, Large-Cell, Anaplastic / Q000235:genetics; D009687:Nuclear Proteins / Q000235:genetics* / Q000378:metabolism; D000090243:Nucleophosmin; D010446:Peptide Fragments; D011505:Protein-Tyrosine Kinases / Q000235:genetics*; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics* / Q000378:metabolism; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012097:Repressor Proteins / Q000235:genetics / Q000378:metabolism
D009687:Nuclear Proteins; D010446:Peptide Fragments; D011993:Recombinant Fusion Proteins; D012097:Repressor Proteins; C034811:tetracycline resistance-encoding transposon repressor protein; D000090243:Nucleophosmin; C000626175:Alk protein, rat; D000077548:Anaplastic Lymphoma Kinase; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases