title: Protective effect of L-arginine against lipid peroxidation in goat epididymal spermatozoa.
abstract: L-arginine plays an important role in physiology of spermatozoa and is shown to enhance the metabolism of these cells. We report here the effect of L-arginine on membrane lipid peroxidation of goat epididymal spermatozoa. Both natural peroxidation as well as that induced by UV radiation, freezing and oxidizing agents have been studied. Irrespective of the nature of induction of peroxidation, L-arginine reduces the extent of lipid peroxidation in a concentration dependent manner. Both L-arginine and alpha-tocopherol act synergistically in protecting against lipid peroxidation induced by the above methods. Thus, in order to provide protection against lipid peroxidation, L-arginine may be added in media used to preserve spermatozoa.
authors.affiliation: Tata Institute of Fundamental Research, Navy Nagar, Mumbai 400 005, India.
authors.forename: S
authors.initials: S
authors.lastname: Srivastava
authors.forename: P
authors.initials: P
authors.lastname: Desai
authors.forename: E
authors.initials: E
authors.lastname: Coutinho
authors.forename: G
authors.initials: G
authors.lastname: Govil
mesh_terms: D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D003080:Cold Temperature; D004822:Epididymis / Q000166:cytology / Q000378:metabolism; D006041:Goats; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism; D013094:Spermatozoa / Q000187:drug effects / Q000378:metabolism*; D014466:Ultraviolet Rays; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D008563:Membrane Lipids; D014810:Vitamin E; D001120:Arginine