title: Juvenile xanthogranuloma: case report with immunohistochemical identification of early and late cytomegalovirus antigens.
abstract: Juvenile xanthogranuloma (JXG) is a dermatological condition of unknown etiology that rarely affects the oral mucosa. There are conflicting reports suggesting that it may represent a reactive virally-induced lesion associated with cytomegalovirus (CMV) infection. The present paper reports an additional case of oral JXG and discusses its possible association with CMV infection. The biotin-streptavidin system was used to detect early and late CMV antigens. Positive immunolabelling for both antigens was demonstrated in some histiocytes in the lesion. These findings suggest that JXG may be associated with CMV infection.
authors.affiliation: Department of Oral Surgery and Pathology, School of Dentistry, Universidade Federal de Minas Gerais, Brasil.
authors.forename: F O
authors.initials: FO
authors.lastname: Vasconcelos
authors.forename: L A
authors.initials: LA
authors.lastname: Oliveira
authors.forename: M D
authors.initials: MD
authors.lastname: Naves
authors.forename: W H
authors.initials: WH
authors.lastname: Castro
authors.forename: R S
authors.initials: RS
authors.lastname: Gomez
mesh_terms: D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis*; D002648:Child; D003587:Cytomegalovirus / Q000276:immunology*; D003586:Cytomegalovirus Infections / Q000175:diagnosis*; D005260:Female; D005500:Follow-Up Studies; D015726:Giant Cells / Q000821:virology; D006644:Histiocytes / Q000276:immunology / Q000821:virology; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008264:Macrophages / Q000821:virology; D009059:Mouth Diseases / Q000276:immunology / Q000821:virology*; D011956:Receptors, Cell Surface / Q000032:analysis; D014763:Viral Matrix Proteins / Q000032:analysis; D014972:Xanthogranuloma, Juvenile / Q000276:immunology / Q000821:virology*; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000956:Antigens, Viral; D011956:Receptors, Cell Surface; D014763:Viral Matrix Proteins; C067980:CD68 antigen, human; D000097382:CD68 Molecule; C037662:EBV-associated membrane antigen, Epstein-Barr virus