NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity.
Regulation of postsynaptic glutamate receptors is one of the main mechanisms for altering synaptic efficacy in the central nervous system. Recent studies have given insight into the upregulation of the NMDA receptor by Src family tyrosine kinases, which bind to scaffolding proteins in the NMDA receptor complex. Src acts as a common step in signalling cascades that link G-protein-coupled receptors with protein kinase C via the intermediary cell-adhesion kinase beta. This signalling to NMDA receptors is required for long-term potentiation in the CA1 region of the hippocampus.
Ali
D W
DW
Department of Biological Sciences, University of Alberta, Alberta, T6G 2E9, Edmonton, Canada.
Salter
M W
MW
D000818:Animals; D051418:Focal Adhesion Kinase 2; D019204:GTP-Binding Proteins / Q000502:physiology; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology; D046911:Macromolecular Substances; D018782:Maze Learning; D051379:Mice; D018345:Mice, Knockout; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000502:physiology*; D009473:Neuronal Plasticity / Q000187:drug effects / Q000502:physiology*; D010766:Phosphorylation; D011493:Protein Kinase C / Q000502:physiology; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D021122:Protein Subunits; D011505:Protein-Tyrosine Kinases / Q000502:physiology; D016194:Receptors, N-Methyl-D-Aspartate / Q000145:classification / Q000187:drug effects / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology*; D015854:Up-Regulation; D019061:src-Family Kinases / Q000502:physiology*
D046911:Macromolecular Substances; D009419:Nerve Tissue Proteins; D021122:Protein Subunits; D016194:Receptors, N-Methyl-D-Aspartate; D011505:Protein-Tyrosine Kinases; D051418:Focal Adhesion Kinase 2; D019061:src-Family Kinases; D011493:Protein Kinase C; D019204:GTP-Binding Proteins