title: Classification of in vivo 1H MR spectra from breast tissue using artificial neural networks.
abstract: BACKGROUND
  The study was designed in order to investigate whether artificial neural networks could be used for analysis of in vivo magnetic resonance (MR) spectra from breast cancer patients.
  
  
  METHODS
  In vivo 1H MR spectra with three different echo times (TE 135, 350 and 450 msec) were acquired from patients with benign and malignant breast lesions and from healthy volunteers, of whom some were breast-feeding. A spectral region (4.0-1.5 ppm) was used as input for artificial neural network analysis, for the attempted classification of the data into different groups.
  
  
  RESULTS
  Data recorded at all three echo times were necessary to obtain the best results. Furthermore, malignant tissue was differentiated from benign tumours using this approach, whereas benign tumours were poorly separated from healthy tissue.
  
  
  CONCLUSIONS
  The results presented here indicate that in vivo MR spectroscopy in conjunction with neural network analysis might be useful for the evaluation of breast lesions.
authors.affiliation: MR Center, SINTEF Unimed, N-7465 Trondheim, Norway.
authors.forename: I J
authors.initials: IJ
authors.lastname: Bakken
authors.forename: D
authors.initials: D
authors.lastname: Axelson
authors.forename: K A
authors.initials: KA
authors.lastname: Kvistad
authors.forename: I S
authors.initials: IS
authors.lastname: Gribbestad
mesh_terms: D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000473:pathology; D001330:Electronic Data Processing; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D016571:Neural Networks, Computer; D011237:Predictive Value of Tests