[In vitro study of the antimutagenic activity of alphahederin].
Authors have studied the antimutagenic power of alphahederin (a saponin extracted from Hedera helix) versus a clastogenic agent, doxorubicin and an aneugenic agent, carbendazim. We have applied a protocol of incorporation of alphahederin (pretreatment, simultaneous treatment and post treatment) to determine a mechanism of action. According to this protocol, alphahederin induces a significant diminution of the rate of micronuclei wathever the phases of the protocol. These results demonstrate the antimutagenic activity of alphahederin with a mechanism of action, both desmutagenic and bioantimutagenic.
Villani
P
P
Laboratoire de biogénotoxicologie (EA 1784), Faculté de médecine, 27, bd Jean-Moulin, 13385 Marseille cedex 5.
Orsière
T
T
Sari-Minodier
I
I
Bouvenot
G
G
Botta
A
A
D000395:Air Pollutants, Occupational / Q000633:toxicity; D000935:Antifungal Agents / Q000494:pharmacology*; D016587:Antimutagenic Agents; D001562:Benzimidazoles / Q000633:toxicity; D002219:Carbamates; D002478:Cells, Cultured; D003571:Cytochalasin B / Q000494:pharmacology; D004317:Doxorubicin / Q000633:toxicity; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D010936:Plant Extracts; D012503:Saponins / Q000494:pharmacology*
D000395:Air Pollutants, Occupational; D000935:Antifungal Agents; D016587:Antimutagenic Agents; D001562:Benzimidazoles; D002219:Carbamates; D009153:Mutagens; D010936:Plant Extracts; D012503:Saponins; C010177:beta-hederin; D003571:Cytochalasin B; D009828:Oleanolic Acid; D004317:Doxorubicin; C006698:carbendazim