title: An autocrine/paracrine mechanism triggered by myocardial stretch induces changes in contractility.
abstract: An autocrine/paracrine mechanism is triggered by stretching the myocardium. This mechanism involves release of angiotensin II, release/increased formation of endothelin, activation of the Na(+)/H(+) exchanger, increase in intracellular Na(+), and the increase in the Ca(2+) transient that underlies the slow force response to stretch. The autocrine/paracrine mechanism could explain how changes in afterload alter cardiac contractility.
authors.affiliation: Centro de Investigaciones Cardiovasculares, Facultad de Ciencias Médicas, Universidad Nacional de La Plata, 1900 La Plata, Argentina.
authors.forename: H E
authors.initials: HE
authors.lastname: Cingolani
authors.forename: N G
authors.initials: NG
authors.lastname: Pérez
authors.forename: M C
authors.initials: MC
authors.lastname: Camilión de Hurtado
mesh_terms: D000818:Animals; D019898:Autocrine Communication / Q000502:physiology*; D009200:Myocardial Contraction / Q000502:physiology*; D009206:Myocardium / Q000378:metabolism*; D019899:Paracrine Communication / Q000502:physiology*