The gastrointestinal transit profile of 14C-labelled poly(acrylic acids): an in vivo study.
The gastrointestinal distribution profiles for three 14C-labelled poly(acrylic acid)s of different average molecular weights and degrees of cross-linking have been established using the rat model. Despite initial differences in transit times and retention characteristics, these structural features were found to be of little influence to the overall gastrointestinal transit of the materials under consideration. No evidence for the systemic absorption of any of the polymers could be identified.
Riley
R G
RG
School of Pharmacy and Biomedical Sciences, University of Portsmouth, UK.
Green
K L
KL
Smart
J D
JD
Tsibouklis
J
J
Davis
J A
JA
Hampson
F
F
Dettmar
P W
PW
Wilber
W R
WR
D000180:Acrylic Resins / Q000493:pharmacokinetics*; D000818:Animals; D002250:Carbon Radioisotopes / Q000493:pharmacokinetics*; D005772:Gastrointestinal Transit; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results
D000180:Acrylic Resins; D002250:Carbon Radioisotopes; C006903:carbopol 940