Diagnosis and management of posttransplant lymphoproliferative disorder in solid-organ transplant recipients.
The Epstein-Barr virus (EBV) has a pivotal pathophysiologic role in the development of most lymphoproliferative disorders that occur after solid-organ transplantation. The term "EBV-associated posttransplant lymphoproliferative disorder" (PTLD) includes all clinical syndromes of EBV-associated lymphoproliferation, ranging from uncomplicated posttransplant infectious mononucleosis to true malignancies that contain clonal chromosomal abnormalities. PTLDs are historically associated with a high mortality rate in patients who have a monoclonal form of the disorder. Recently described approaches to pathology, diagnosis, treatment, and preventive strategies of PTLD, however, have the potential to improve outcome.
Preiksaitis
J K
JK
Division of Infectious Diseases, Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. jkp@bugs.uah.ualberta.ca
Keay
S
S
D000998:Antiviral Agents / Q000627:therapeutic use; D004854:Herpesvirus 4, Human / Q000302:isolation & purification* / Q000472:pathogenicity; D006801:Humans; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000517:prevention & control / Q000628:therapy / Q000821:virology; D016377:Organ Transplantation; D011183:Postoperative Complications
D000998:Antiviral Agents