Maxi-K(Ca), a Unique Member of the Voltage-Gated K Channel Superfamily.
Large-conductance, voltage-, and Ca(2+)-sensitive K(+) (maxi-K(Ca)) channels regulate neuronal and smooth muscle excitability. Their pore-forming alpha-subunit shows similarities with voltage-gated channels and indeed can open in the practical absence of Ca(2+). The NH(2) terminus is unique, with a seventh transmembrane segment involved in beta-subunit modulation. The long COOH terminus is implied in Ca(2+) modulation.
Toro
L.
L
Dept. of Anesthesiology at the University of California at Los Angeles School of Medicine, Los Angeles, CA 90095-1778, USA.
Wallner
M.
M
Meera
P.
P
Tanaka
Y.
Y