Understanding the Physiology of the Blood-Brain Barrier: In Vitro Models.
Endothelial cells exposed to inductive central nervous system factors differentiate into a blood-brain barrier phenotype. The blood-brain barrier frequently obstructs the passage of chemotherapeutics into the brain. Tissue culture systems have been developed to reproduce key properties of the intact blood-brain barrier and to allow for testing of mechanisms of transendothelial drug permeation.
Grant
Gerald A.
GA
Department of Neurological Surgery, University of Washington School of Medicine, 325 9th Ave., Seattle, WA 98104, USA.
Abbott
N. Joan
NJ
Janigro
Damir
D