Basic science of articular cartilage repair.
As the ability to understand the peculiarities of successful healing of articular cartilage defects moves forward, it becomes clear that this complex orthopaedic problem soon will be successfully addressed. A multidisciplinary approach, combining clinical experience, cogent biomaterial designs, new cell biologic processes, biomechanical assessment, and modern molecular biology, clearly is leading toward clinically acceptable, viable, and consistent articular cartilage regeneration.
Athanasiou
K A
KA
Department of Bioengineering, Rice University, Houston, Texas, USA.
Shah
A R
AR
Hernandez
R J
RJ
LeBaron
R G
RG
D001696:Biomechanical Phenomena; D019485:Bone Morphogenetic Proteins / Q000627:therapeutic use; D002357:Cartilage Diseases / Q000503:physiopathology* / Q000628:therapy*; D002358:Cartilage, Articular / Q000293:injuries / Q000503:physiopathology* / Q000637:transplantation; D002686:Chitin / Q000031:analogs & derivatives / Q000627:therapeutic use; D048271:Chitosan; D020219:Chondrogenesis; D003094:Collagen / Q000627:therapeutic use; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use; D005346:Fibroblast Growth Factors / Q000627:therapeutic use; D006801:Humans; D006820:Hyaluronic Acid / Q000627:therapeutic use; D007719:Knee Joint / Q000503:physiopathology*; D012038:Regeneration; D012685:Sepharose / Q000627:therapeutic use; D033581:Stem Cell Transplantation; D014945:Wound Healing
D019485:Bone Morphogenetic Proteins; D015718:Fibrin Tissue Adhesive; D002686:Chitin; D005346:Fibroblast Growth Factors; D006820:Hyaluronic Acid; D003094:Collagen; D012685:Sepharose; D048271:Chitosan