Temporary reversal by topotecan of marked insulin resistance in a patient with myelodysplastic syndrome: case report and possible mechanism for tumor necrosis factor alpha (TNF-alpha)-induced insulin resistance.
Tumor necrosis factor-alpha (TNF-alpha) is an important mediator of insulin resistance in obesity and diabetes through its ability to decrease the tyrosine kinase activity of the insulin receptor. We report here a remarkable degree of insulin resistance in a patient with adult respiratory distress syndrome and myelodysplasia.
Huntington
M O
MO
Eastern Idaho Regional Medical Center, Idaho Falls, Idaho, USA.
Krell
K E
KE
Armour
W E
WE
Liljenquist
J E
JE
D000368:Aged; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D009190:Myelodysplastic Syndromes / Q000378:metabolism*; D013997:Time Factors; D019772:Topotecan / Q000494:pharmacology*; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000502:physiology*
D004791:Enzyme Inhibitors; D014409:Tumor Necrosis Factor-alpha; D019772:Topotecan