Mice lacking the Nkx6.2 (Gtx) homeodomain transcription factor develop and reproduce normally.
The Nkx homeobox genes are expressed in a variety of developing tissues and have been implicated in controlling tissue patterning and cell differentiation. Expression of Nkx6.2 (Gtx) was previously observed in the embryonic neural tube, testis, and differentiating oligodendrocytes. To investigate the role of Nkx6.2 in the control of cell specification and differentiation, we generated mice with null mutations in Nkx6.2 using the standard gene targeting approach. Null mutant mice were viable and fertile without apparent histological and immunohistochemical changes in the central nervous systems and testis. The absence of detectable phenotypes suggests a redundant function of Nkx6.2 in mouse development.
Cai
J
J
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, Kentucky 40292, USA.
Qi
Y
Y
Wu
R
R
Modderman
G
G
Fu
H
H
Liu
R
R
Qiu
M
M
D000818:Animals; D030161:Avian Proteins; D002454:Cell Differentiation; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology; D004298:Dopamine / Q000378:metabolism; D018390:Gene Targeting; D005801:Genes, Homeobox; D018398:Homeodomain Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D007150:Immunohistochemistry; D051379:Mice; D018345:Mice, Knockout; D009186:Myelin Sheath / Q000235:genetics / Q000378:metabolism; D009474:Neurons / Q000737:chemistry / Q000166:cytology*; D009836:Oligodendroglia / Q000737:chemistry / Q000166:cytology*; D010641:Phenotype; D012098:Reproduction; D012701:Serotonin / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000502:physiology*
D030161:Avian Proteins; D018398:Homeodomain Proteins; C404163:Nkx-6.2 protein, chicken; D014157:Transcription Factors; D012701:Serotonin; D004298:Dopamine