Fatal hemolysis after high-dose etoposide: is benzyl alcohol to blame?
A 53-year-old African-American man with relapsed non-Hodgkin's lymphoma developed seizures and respiratory arrest 2 hours after an infusion of high-dose etoposide in preparation for an autologous bone marrow transplant. Laboratory tests revealed both rapid hemolysis and severe metabolic acidosis. The patient died the following day. Based on toxicities observed, we suspect that our patient possessed an ethnic polymorphism of the enzyme alcohol dehydrogenase. Further research is required to determine the relationship between the benzyl alcohol metabolic rate and toxicity and genetic polymorphisms of alcohol dehydrogenase in African-Americans.
Smith
A L
AL
Department of Pharmacy, State University of New York, Syracuse, USA.
Haider
K
K
Schachtner
J M
JM
Mathur
S
S
Vanorden
R
R
Gentile
T C
TC
D000138:Acidosis / Q000139:chemically induced*; D000349:Africa / Q000208:ethnology; D000426:Alcohol Dehydrogenase / Q000235:genetics; D019905:Benzyl Alcohol / Q000008:administration & dosage / Q000009:adverse effects*; D004338:Drug Combinations; D005047:Etoposide / Q000009:adverse effects*; D017809:Fatal Outcome; D006461:Hemolysis; D006801:Humans; D007275:Injections, Intravenous; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics; D012131:Respiratory Insufficiency / Q000139:chemically induced*; D012640:Seizures / Q000139:chemically induced*
D004338:Drug Combinations; D005047:Etoposide; D000426:Alcohol Dehydrogenase; D019905:Benzyl Alcohol