title: Mechanisms of alcoholic liver disease: cytokines.
abstract: This article represents the proceedings of a workshop at the 2000 ISBRA Meeting in Yokohama, Japan. The chair was Manuela G. Neuman. The presentations were (1) New aspects of hepatic fibrosis, by D. A. Brenner; (2) Cellular immune response in hepatitis C models, by B. Rehermann; (3) The role of interleukin-10 in acute alcoholic hepatitis, by J. Taieb, S. Chollet-Martin, M. Cohard, J. J. Garaud, and T. Poynard; (4) Cytokine-mediated apoptosis in vitro, by M. G. Neuman; (5) Signaling for apoptosis and repair in vitro, by G. G. Katz, R. G. Cameron, N. H. Shear, and M. G. Neuman; (6) Interferons activate the P42/44 mitogen-activated protein kinase and Janus Kinase signal transducers and activation of transcription (JAK-STAT) signaling pathways in hepatocytes: Differential regulation by acute ethanol via a protein kinase C-dependent mechanism, by B. Gao; (7) Genetic polymorphisms of interleukin-1 in association with the development of Japanese alcoholic liver disease, by M. Takamatsu, M. Yamauchi, M. Ohata, S. Saito, S. Maeyama, T. Uchikoshi, and G. Toda; and (8) Increased levels of macrophage migration inhibitory factor in sera from patients with alcoholic liver diseases, by T. Kumagi, S. M. F. Akbar, M. Abe, K. Michitaka, N. Horiike, and M. Onji.
authors.affiliation: Sunnybrook and Women's College Health Sciences Centre, University of Toronto, Ontario, Canada. manuela@sten.sunnybrook.utoronto.ca
authors.forename: M G
authors.initials: MG
authors.lastname: Neuman
authors.forename: D A
authors.initials: DA
authors.lastname: Brenner
authors.forename: B
authors.initials: B
authors.lastname: Rehermann
authors.forename: J
authors.initials: J
authors.lastname: Taieb
authors.forename: S
authors.initials: S
authors.lastname: Chollet-Martin
authors.forename: M
authors.initials: M
authors.lastname: Cohard
authors.forename: J J
authors.initials: JJ
authors.lastname: Garaud
authors.forename: T
authors.initials: T
authors.lastname: Poynard
authors.forename: G G
authors.initials: GG
authors.lastname: Katz
authors.forename: R G
authors.initials: RG
authors.lastname: Cameron
authors.forename: N H
authors.initials: NH
authors.lastname: Shear
authors.forename: B
authors.initials: B
authors.lastname: Gao
authors.forename: M
authors.initials: M
authors.lastname: Takamatsu
authors.forename: M
authors.initials: M
authors.lastname: Yamauchi
authors.forename: M
authors.initials: M
authors.lastname: Ohata
authors.forename: S
authors.initials: S
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Maeyama
authors.forename: T
authors.initials: T
authors.lastname: Uchikoshi
authors.forename: G
authors.initials: G
authors.lastname: Toda
authors.forename: T
authors.initials: T
authors.lastname: Kumagi
authors.forename: S M
authors.initials: SM
authors.lastname: Akbar
authors.forename: M
authors.initials: M
authors.lastname: Abe
authors.forename: K
authors.initials: K
authors.lastname: Michitaka
authors.forename: N
authors.initials: N
authors.lastname: Horiike
authors.forename: M
authors.initials: M
authors.lastname: Onji
mesh_terms: D000428:Alcohol Drinking / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D000818:Animals; D016207:Cytokines / Q000378:metabolism*; D016174:Hepacivirus / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000378:metabolism; D007378:Interleukins / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism; D008108:Liver Diseases, Alcoholic / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D008263:Macrophage Migration-Inhibitory Factors / Q000097:blood / Q000276:immunology; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism; D011110:Polymorphism, Genetic / Q000235:genetics; D011493:Protein Kinase C / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D007378:Interleukins; D008263:Macrophage Migration-Inhibitory Factors; D010713:Phosphatidylcholines; D014409:Tumor Necrosis Factor-alpha; C005152:lipostabil; D007371:Interferon-gamma; D011493:Protein Kinase C; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases