Asymmetric synthesis of quaternary alpha-amino phosphonates using sulfinimines.
The addition of lithium diethylphosphonate to enantiopure ketosulfinimines is highly diastereoselective (>95%), affording the first examples of quaternary alpha-alkyl alpha-amino (arylmethyl)phosphonates.
Davis
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Department of Chemistry, Temple University, Philadelphia, Pennsylvania 19122, USA. fdavis@astro.ocis.temple.edu
Lee
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Yan
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Titus
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D018360:Crystallography, X-Ray; D007097:Imines / Q000737:chemistry*; D007202:Indicators and Reagents; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013441:Sulfinic Acids / Q000737:chemistry*
D007097:Imines; D007202:Indicators and Reagents; D009943:Organophosphorus Compounds; D013441:Sulfinic Acids