Depression: a major, unrecognized risk factor for osteoporosis?
Existing studies of the relationship between depression and osteoporosis have been heterogeneous in their design and use of diagnostic instruments for depression, which might have contributed to the different results on the comorbidity of these two conditions. Nevertheless, these studies reveal a strong association between depression and osteoporosis. Endocrine factors such as depression-induced hypersecretion of corticotropin-releasing hormone and hypercortisolism, hypogonadism, growth hormone deficiency and increased concentration of circulating interleukin 6, might play a crucial role in the bone loss observed in subjects suffering from major depression.
Cizza
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Clinical Neuroendocrinology Branch, NIMH, Bethesda, MD, USA. gcizza@codon.nih.gov
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Chrousos
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D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D015519:Bone Density; D015331:Cohort Studies; D003430:Cross-Sectional Studies; D003863:Depression / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D050723:Fractures, Bone / Q000209:etiology / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D010024:Osteoporosis / Q000209:etiology* / Q000378:metabolism / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000009:adverse effects / Q000627:therapeutic use; D012307:Risk Factors
D000928:Antidepressive Agents; D011619:Psychotropic Drugs