Clarithromycin resistance and eradication of Helicobacter pylori in children.
Outcome of Helicobacter pylori infection was analyzed in 61 children treated with a triple therapy including clarithromycin. Bacterial eradication was obtained in all children with clarithromycin-susceptible strains but not in children with clarithromycin-resistant ones (P = 0.0001). H. pylori antimicrobial susceptibility is mandatory before choosing a treatment, and clarithromycin should be avoided in case of resistance.
Kalach
N
N
Division of Gastroenterology, Department of Pediatrics, Hôpital Saint Vincent de Paul, 75674 Paris Cedex 14, France.
Benhamou
P H
PH
Campeotto
F
F
Bergeret
M
M
Dupont
C
C
Raymond
J
J
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D017291:Clarithromycin / Q000494:pharmacology* / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori / Q000187:drug effects*; D006801:Humans; D008297:Male
D017291:Clarithromycin