Serum cystatin C in patients with myeloma.
BACKGROUND
Cystatin C is a low molecular weight protein thought to be synthesised by all nucleated cells and freely filtered by the kidney. It has been proposed as a marker for GFR; however, it has been suggested that there may be limitations to its use, because it may be over-expressed in some tumour cells and the abnormal tissue growth may also lead to an increased circulating level.


METHODS
We investigated the serum cystatin C levels in 60 patients with myeloma, comparing results with those for serum creatinine, beta(2)-microglobulin and the paraprotein concentration.


RESULTS
We found no correlation between cystatin C and the paraprotein concentration in these patients.


CONCLUSIONS
These results suggest that disease burden does not correlate to the circulating level of cystatin C in patients with myeloma.
Finney
H
H
Department of Clinical Biochemistry, The Royal London Hospital, Barts and The London NHS Trust, Whitechapel, E1 1BB, London, UK. Hazel.Finney@bartsandthelondon.nhs.uk
Williams
A H
AH
Price
C P
CP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers / Q000097:blood; D003404:Creatinine / Q000097:blood*; D055316:Cystatin C; D015891:Cystatins / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D016018:Least-Squares Analysis; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood* / Q000150:complications / Q000175:diagnosis*; D010265:Paraproteinemias / Q000209:etiology; D010266:Paraproteins / Q000032:analysis*; D001613:beta 2-Microglobulin / Q000097:blood
D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D010266:Paraproteins; D001613:beta 2-Microglobulin; D003404:Creatinine