Metabolic effects of metaproterenol overdose: hypokalemia, hyperglycemia and hyperlactatemia.
This case report of metaproterenol toxicity was associated with hypokalemia, hyperglycemia and hyperlactatemia. A similar triad has been reported in acute theophylline poisoning. Hypokalemia and hyperglycemia have been reported with other beta-agonists, but not metaproterenol. Patients presenting with the metabolic triad of hypokalemia, hyperglycemia, and hyperlactatemia should have theophylline and beta-agonist toxicity included in their differential diagnosis because the prognosis and therapy of these 2 intoxications is markedly different.
Barnewolt
B A
BA
Department of Emergency Medicine, Tufts University School of Medicine, New England Medical Center, Boston, Massachusetts, USA.
Walter
F G
FG
Bey
T A
TA
D000293:Adolescent; D000318:Adrenergic beta-Agonists / Q000506:poisoning*; D001993:Bronchodilator Agents / Q000506:poisoning*; D062787:Drug Overdose / Q000097:blood; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D007008:Hypokalemia / Q000139:chemically induced*; D019344:Lactic Acid / Q000097:blood; D009921:Metaproterenol / Q000506:poisoning*
D000318:Adrenergic beta-Agonists; D001993:Bronchodilator Agents; D019344:Lactic Acid; D009921:Metaproterenol