title: Regioselective palladium-catalyzed arylation of 2-furaldehyde.
abstract: An efficient regioselective method for the direct arylation of 2-furaldehyde to provide a range of pi-diverse 5-aryl-2-formylfuran derivatives is described. The method employs functionalized aryl halides and a catalytic amount of palladium(II) chloride under relatively mild conditions.
authors.affiliation: GlaxoSmithKline, Chemical Development, Five Moore Drive, P.O. Box 13398, Research Triangle Park, North Carolina 27709, USA. msm81971@gsk.com
authors.forename: M S
authors.initials: MS
authors.lastname: McClure
authors.forename: B
authors.initials: B
authors.lastname: Glover
authors.forename: E
authors.initials: E
authors.lastname: McSorley
authors.forename: A
authors.initials: A
authors.lastname: Millar
authors.forename: M H
authors.initials: MH
authors.lastname: Osterhout
authors.forename: F
authors.initials: F
authors.lastname: Roschangar
mesh_terms: D000478:Alkylation; D002384:Catalysis; D005662:Furaldehyde / Q000737:chemistry*; D007202:Indicators and Reagents; D010165:Palladium / Q000737:chemistry*; D010944:Plants / Q000737:chemistry
chemical_list: D007202:Indicators and Reagents; D010165:Palladium; D005662:Furaldehyde