Jesterone and hydroxy-jesterone antioomycete cyclohexenone epoxides from the endophytic fungus Pestalotiopsis jesteri.
Jesterone and hydroxy-jesterone are novel highly functionalized cyclohexenone epoxides isolated from a newly described endophytic fungal species--Pestalotiopsis jesteri. They were purified from cultures of the fungus by bioassay guided fractionation using Pythium ultimum as the indicator organism. Jesterone, in particular, displays selective antimycotic activity against the oomycetous fungi which are some of the most plant pathogenic of all disease causing fungi. The possible importance of these cyclohexenones to the biology of the endophytic fungus-host plant relationship is also discussed.
Li
J Y
JY
Department of Plant Sciences, Montana State University, Bozeman 59717, USA.
Strobel
G A
GA
D000475:Alkenes / Q000302:isolation & purification*; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003510:Cyclohexanes / Q000737:chemistry*; D004852:Epoxy Compounds / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009868:Oomycetes / Q000187:drug effects*; D020037:Sordariales / Q000737:chemistry*
D000475:Alkenes; D000935:Antifungal Agents; D003510:Cyclohexanes; D004852:Epoxy Compounds; C431025:jesterone