Unraveling the Mystery of Goldblatt Hypertension.
In hypertension caused by unilateral renal artery stenosis, the nonstenotic kidney becomes renin depleted but fails to prevent hypertension. The nonstenotic kidney mysteriously develops elevated intrarenal angiotensin II (ANG II) content. Rats chronically infused with ANG II exhibit a similar hypertensive process. The augmentation of intrarenal ANG II is due to receptor-mediated internalization and continued ANG II formation, which provide a hypertensinogenic stimulus.
Navar
L. Gabriel
LG
Dept. of Physiology, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Zou
Lixian
L
Von Thun
Annette
A
Tarng Wang
Chi
C
Imig
John D.
JD
Mitchell
Kenneth D.
KD