title: Effect of administration route on FES uptake into MCF-7 tumors.
abstract: We have observed that intraperitoneal administration of [(18)F]fluoroestradiol (FES), a radiolabeled estrogen receptor ligand, results in higher abdominal organ uptake and slower blood clearance than intravenous administration in female mice. In SCID mice bearing MCF-7 human tumors SC, IP administration resulted in tumor uptake that was only about one third that obtained with IV administration. Thus, the route of administration of a radiopharmaceutical for imaging or radiotherapy of a tumor in the abdomen, an ovarian tumor, for example, could have a profound effect on the efficiency and selectivity of delivery of the agent to the tumor.
authors.affiliation: Department of Chemistry, Washington University, St. Louis, MO, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Downer
authors.forename: L A
authors.initials: LA
authors.lastname: Jones
authors.forename: J A
authors.initials: JA
authors.lastname: Katzenellenbogen
authors.forename: M J
authors.initials: MJ
authors.lastname: Welch
mesh_terms: D000818:Animals; D001943:Breast Neoplasms / Q000378:metabolism; D004958:Estradiol / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D051379:Mice; D014407:Tumor Cells, Cultured
chemical_list: C062756:1-fluoroestradiol; D004958:Estradiol