title: Contribution of perfusion pressure to vascular resistance response during head-up tilt.
abstract: We measured brachial and femoral artery flow velocity in eight subjects and peroneal and median muscle sympathetic nerve activity (MSNA) in five subjects during tilt testing to 40 degrees. Tilt caused similar increases in MSNA in the peroneal and median nerves. Tilt caused a fall in femoral artery flow velocity, whereas no changes in flow velocity were seen in the brachial artery. Moreover, with tilt, the increase in the vascular resistance employed (blood pressure/flow velocity) was greater and more sustained in the leg than in the arm. The ratio of the percent increase in vascular resistance in leg to arm was 2.5:1. We suggest that the greater vascular resistance effects in the leg were due to an interaction between sympathetic nerve activity and the myogenic response.
authors.affiliation: Division of Pulmonary, Allergy, and Critical Care, The Milton S. Hershey Medical Center, The Pennsylvania State University College of Medicine, Hershey, 17033, USA. vimadoje@psu.edu
authors.forename: V A
authors.initials: VA
authors.lastname: Imadojemu
authors.forename: M E
authors.initials: ME
authors.lastname: Lott
authors.forename: K
authors.initials: K
authors.lastname: Gleeson
authors.forename: C S
authors.initials: CS
authors.lastname: Hogeman
authors.forename: C A
authors.initials: CA
authors.lastname: Ray
authors.forename: L I
authors.initials: LI
authors.lastname: Sinoway
mesh_terms: D000328:Adult; D001132:Arm / Q000098:blood supply / Q000294:innervation; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007866:Leg / Q000098:blood supply / Q000294:innervation; D008297:Male; D008475:Median Nerve / Q000502:physiology; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000294:innervation; D010543:Peroneal Nerve / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D018667:Tilt-Table Test; D014655:Vascular Resistance / Q000502:physiology*