Key Roles of Renal Aquaporins in Water Balance and Water-Balance Disorders.
The discovery of aquaporins by Agre and co-workers provided an answer to the long-standing biophysical question of how water can pass cell membranes. The identification and characterization of several aquaporins expressed in the kidney has allowed detailed insight, at the molecular level, into the fundamental physiology and pathophysiology of renal water metabolism.
Nielsen
Søren
S
Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus, Denmark.
Kwon
Tae-Hwan
TH
Frøkiaer
Jørgen
J
Knepper
Mark A.
MA