Total synthesis of (+)-arteanniun M using the tandem oxy-Cope/ene reaction.
[see reaction]. The first total synthesis of (+)-arteannuin M was accomplished using the tandem oxy-Cope/transannular ene reaction as the key step to construct the bicyclic core of the natural product. The tandem reaction proceeded with high diastereo- and enantiomeric excess.
Barriault
L
L
Department of Chemistry, University of Ottawa, 10 Marie Curie, Ottawa, Ontario, Canada, K1N 6N5. lbarriau@science.uottawa.ca
Deon
D H
DH
D037621:Artemisinins; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry; D013237:Stereoisomerism
D037621:Artemisinins; D012717:Sesquiterpenes; C031327:artemisinin