title: Quantitative bacillary response to treatment in Mycobacterium tuberculosis infected and M. africanum infected adults with pulmonary tuberculosis.
abstract: Data regarding possible differences in microbiological response to therapy of disease caused by Mycobacterium tuberculosis and M. africanum are limited. Presenting clinical characteristics and sputum bacillary load during standard short-course chemotherapy in patients with newly-diagnosed pulmonary tuberculosis due to M. tuberculosis (n = 7) and M. africanum (n = 6) were compared. Changes in sputum bacillary load were measured using quantitative acid-fast bacilli smears, colony forming unit assay, and time until positive culture in the BACTEC radiometric system. Presentation and response to short course chemotherapy were comparable between patients infected with M. tuberculosis and those infected with M. africanum.
authors.affiliation: Department of Medical Microbiology, Makerere University, Joint Clinical Research Centre, Kampala, Uganda. mlj10@po.cwru.edu
authors.forename: M L
authors.initials: ML
authors.lastname: Joloba
authors.forename: J L
authors.initials: JL
authors.lastname: Johnson
authors.forename: A
authors.initials: A
authors.lastname: Namale
authors.forename: A
authors.initials: A
authors.lastname: Morrissey
authors.forename: A E
authors.initials: AE
authors.lastname: Assegghai
authors.forename: S
authors.initials: S
authors.lastname: Rüsch-Gerdes
authors.forename: R D
authors.initials: RD
authors.lastname: Mugerwa
authors.forename: J J
authors.initials: JJ
authors.lastname: Ellner
authors.forename: K D
authors.initials: KD
authors.lastname: Eisenach
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000494:pharmacology* / Q000652:urine; D001407:Bacillus / Q000187:drug effects* / Q000302:isolation & purification; D015169:Colony Count, Microbial; D005260:Female; D006801:Humans; D008297:Male; D009161:Mycobacterium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D010349:Patient Compliance; D011446:Prospective Studies; D013183:Sputum / Q000187:drug effects / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000382:microbiology*
chemical_list: D000995:Antitubercular Agents