Ossifying fibromyxoid tumor of soft parts: report of a case with novel cytogenetic findings.
A slowly growing tumor of the left thenar region in a 40-year-old man had the classic features of an ossifying fibromyxoid tumor of soft parts, including an incomplete shell of lamellar bone; a center composed of nodular aggregates of small spindled, oval, and stellate cells in abundant myxoid stroma; and strong expression of vimentin, S-100, and neuron-specific enolase by the tumor cells. Clonal chromosomal abnormalities included loss of a chromosome 6, extra material of unknown origin attached to the long arm of chromosome 12, and an unbalanced translocation involving the short arm of a chromosome 6 and the long arm of a chromosome 14. The karyotype was interpreted as 45,XY, der(6;14)(p10;q10),add(12)(q24.3). The chromosomal abnormalities suggest osteochondroblastic rather than neuronal or schwannian lineage.
Sovani
V
V
Department of Pathology, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555-0359, USA.
Velagaleti
G V
GV
Filipowicz
E
E
Gatalica
Z
Z
Knisely
A S
AS
D000328:Adult; D002869:Chromosome Aberrations / Q000473:pathology; D025063:Chromosome Disorders; D002881:Chromosomes, Human, Pair 12 / Q000235:genetics; D002883:Chromosomes, Human, Pair 14 / Q000235:genetics; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D018214:Fibroma, Ossifying / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007621:Karyotyping; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D012983:Soft Tissue Neoplasms / Q000737:chemistry / Q000235:genetics / Q000473:pathology*; D014746:Vimentin / Q000032:analysis
D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase