Hepatic hemangioendothelioma associated with production of humoral thyrotropin-like factor.
We report on 7 patients referred for treatment of hepatic hemangioendothelioma with increased thyrotropin levels. The serum thyroxine level was decreased in 4 and increased in 2. Immunohistochemistry showed positive staining of tumor, but not of normal liver tissue, for thyrotropin. We propose secretion by the tumor of a thyrotropin-like factor.
Ayling
R M
RM
Department of Clinical Biochemistry, King's College Hospital, Denmark Hill, London SE5 9RS, United Kingdom.
Davenport
M
M
Hadzic
N
N
Metcalfe
R
R
Buchanan
C R
CR
Howard
E R
ER
Mieli-Vergani
G
G
D005260:Female; D006390:Hemangioendothelioma / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008113:Liver Neoplasms / Q000378:metabolism*; D008297:Male; D013972:Thyrotropin / Q000096:biosynthesis*; D013974:Thyroxine / Q000032:analysis
D013972:Thyrotropin; D013974:Thyroxine