Reprogramming T cells: the role of extracellular matrix in coordination of T cell activation and migration.
The stable immunological synapse between a T cell and antigen-presenting cell coordinates migration and activation. Three-dimensional collagen gels transform this interaction into a series of transient hit-and-run encounters. Here we integrate these alternative modes of interaction in a model for primary T cell activation and effector function in vivo.
Dustin
M L
ML
The Molecular Pathogenesis Program, Skirball Institute of Molecular Medicine and the Department of Pathology, New York University School of Medicine, 540 First Avenue, 10016, New York, NY, USA. dustin@saturn.med.nyu.edu
de Fougerolles
A R
AR
D000818:Animals; D002465:Cell Movement / Q000276:immunology*; D005109:Extracellular Matrix / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation / Q000276:immunology*; D009928:Organ Specificity / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*