A rhodium carbene cyclization-cycloaddition cascade strategy toward the pseudolaric acids.
A rhodium carbene intramolecular cyclization-cycloaddition cascade was employed as the key reaction in the synthesis of the nucleus of the cytotoxic diterpenoids pseudolaric acids A and B.
Chiu
P
P
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, P. R. China. pchiu@hkucc.hku.hk
Chen
B
B
Cheng
K F
KF
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D003500:Cyclization; D004224:Diterpenes / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D013237:Stereoisomerism
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D007202:Indicators and Reagents; C058391:pseudolaric acid B; C058390:pseudolaric acid A