Fluid Shear Stress Modulation of Gene Expression in Endothelial Cells.
The vascular endothelium, lining the blood vessel wall, is constantly exposed to wall shear stresses generated by flowing blood. Gene regulation, critical for endothelial cell function, depends on complex interactions at the promoter level and utilizes overlapping signal transduction cascades to activate the expression of genes involved in many biological processes.
Braddock
Martin
M
Vascular Diseases Research Unit, Glaxo-Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts SG1 2NY, UK.
Schwachtgen
Jean-Luc
JL
Houston
Parul
P
Dickson
Marion C.
MC
Lee
Michael J.
MJ
Campbell
Callum J.
CJ