title: A prenyloxycoumarin from Psiadia dentata.
abstract: A new coumarin identified as 5-hydroxy-6-methoxy-7-(3-methyl-but-2-enyloxy)-2H-1-benzopyran-2-one (isoobtusitin) was isolated from Psiadia dentata. This compound showed, in vitro, a moderate inhibitory activity against poliovirus and a very weak activity against (HIV), whereas it was inactive against (HSV1), (VSV), and murine tumoral cell lines (3LL, L1210).
authors.affiliation: UPRES Synthèse et Extraction de Molécules à Visée Thérapeutique Faculté de Pharmacie, Rennes, France.
authors.forename: H
authors.initials: H
authors.lastname: Fortin
authors.forename: S
authors.initials: S
authors.lastname: Tomasi
authors.forename: P
authors.initials: P
authors.lastname: Jaccard
authors.forename: V
authors.initials: V
authors.lastname: Robin
authors.forename: J
authors.initials: J
authors.lastname: Boustie
mesh_terms: D000818:Animals; D019380:Anti-HIV Agents / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D017955:Poliovirus / Q000187:drug effects; D017508:Reunion; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: C436726:5-hydroxy-6-methoxy-7-(3-methyl-but-2-enyloxy)-2H-1-benzopyran-2-one; D019380:Anti-HIV Agents; D000972:Antineoplastic Agents, Phytogenic; D000998:Antiviral Agents; D003374:Coumarins