title: HLA alleles and haplotypes in the Turkish population: relatedness to Kurds, Armenians and other Mediterraneans.
abstract: Turkish and Kurdish HLA profiles are studied for the first time. The comparative study of their allele frequencies, characteristic haplotypes, genetic distances with other Mediterraneans is complemented by neighbor-joining dendrograms and correspondence analyses. Turks, Kurds, Armenians, Iranians, Jews, Lebanese and other (Eastern and Western) Mediterranean groups seem to share a common ancestry: the older "Mediterranean" substratum. No sign of the postulated Indo-European (Aryan) invasion (1200 B.C.) is detected by our genetic analysis. It is concluded that this invasion, if occurred, had a relatively few invaders in comparison to the already settled populations, i.e. Anatolian Hittite and Hurrian groups (older than 2000 B.C.). These may have given rise to present-day Kurdish, Armenian and Turkish populations.
authors.affiliation: Department of Immunology and Molecular Biology, H. 12 de Octubre, Universidad Complutense, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
authors.forename: M
authors.initials: M
authors.lastname: Karin
authors.forename: N
authors.initials: N
authors.lastname: Bendikuze
authors.forename: E
authors.initials: E
authors.lastname: Gomez-Casado
authors.forename: J
authors.initials: J
authors.lastname: Moscoso
authors.forename: C
authors.initials: C
authors.lastname: Silvera
authors.forename: F S
authors.initials: FS
authors.lastname: Oguz
authors.forename: A
authors.initials: A
authors.lastname: Sarper Diler
authors.forename: A
authors.initials: A
authors.lastname: De Pacho
authors.forename: L
authors.initials: L
authors.lastname: Allende
authors.forename: J
authors.initials: J
authors.lastname: Guillen
authors.forename: J
authors.initials: J
authors.lastname: Martinez Laso
mesh_terms: D000483:Alleles; D001136:Armenia; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D006684:HLA-DR Antigens / Q000235:genetics; D006239:Haplotypes / Q000276:immunology*; D006801:Humans; D019083:Mediterranean Region; D014421:Turkey
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens