Modelling the dose-volume response of the spinal cord, based on the idea of damage to contiguous functional subunits.
OBJECTIVE
To investigate the response of the spinal cord of experimental animals to homogeneous irradiation, the main purpose being to propose a new version of the Critical Volume Normal Tissue Complication Probability (NTCP) model, incorporating spatial correlation between damaged functional subunits (FSU).


METHODS
The standard Critical Volume NTCP model and its modified version, the Contiguous Damage model promoted here, are described in mathematical terms. Also, a fiber-like structure of the spinal cord is considered, which is a more complex structure than the standard Critical Volume NTCP model assumes. It is demonstrated that the Contiguous Damage model predicts different responses to two-segment irradiation and to single-segment irradiation to the same combined length as observed in experiments on rats, a result that cannot be described by the standard Critical Volume NTCP model.


CONCLUSIONS
Both the Critical Volume model and the Contiguous Damage model, are fitted to two sets of canine spinal cord radiation data corresponding to two different fractionation regimes of irradiation. Whole-organ irradiation as well as partial irradiation to different lengths are considered, allowing the investigation of dose-volume effects. Formal goodness-of-fit investigation shows that both models fit the canine spinal cord data equally well.
Stavreva
N
N
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, 32 Fruit St, Boston, MA 02114, USA.
Niemierko
A
A
Stavrev
P
P
Goitein
M
M
D000818:Animals; D003627:Data Interpretation, Statistical; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D008954:Models, Biological; D011833:Radiation Injuries, Experimental / Q000209:etiology; D051381:Rats; D013116:Spinal Cord / Q000033:anatomy & histology / Q000528:radiation effects*; D013119:Spinal Cord Injuries / Q000209:etiology