[Expression of focal adhesion kinase in lymphatic endothelial cells of metastasis].
This study was directed at the expression of focal adhesion kinase (pp125FAK) which is located together with vinculin and talin in the spot of cellular adhesion. The authors' intention was to collect reliable data on this important kinase in the signal pathways so as to provide in-depth materials for exploring the mechanism of tumor metastasis to lymphatic vessels. The immunohistochemical method was used to study the expression of FAK in lymphatic endothelial cells of metastaltci adenocarcinoma of rectum and its adjacent lymph-nodes. The result demonstrated that lymphatic endothelial cells expressed pp125FAK when lymphatic vessels were invaded by cancer cells. Reaction production was located in the cytoplasm. This study provides that there was a strong correlation between the expression of FAK in lymphatic endothelial cells and the metastasis of cancer to lymphatic vessels.
Chen
Y
Y
Department of Anatomy, School of Basic Medical Sciences, WCUMS, Chengdu 610041.
Zhang
X
X
Li
R
R
Liu
Z
Z
Jin
S
S
D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D004729:Endothelium, Lymphatic / Q000201:enzymology*; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D008207:Lymphatic Metastasis; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis*; D012004:Rectal Neoplasms / Q000201:enzymology* / Q000473:pathology; D015398:Signal Transduction
D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human