title: Distribution of various calcium channel alpha(1) subunits in murine DRG neurons and antinociceptive effect of omega-conotoxin SVIB in mice.
abstract: Immunohistological study revealed the differential localization of subtypes of voltage-dependent calcium channels in the dorsal root ganglion neurons. Intrathecal injection of omega-conotoxin SVIB, an analogue of omega-conotoxin GVIA, which acts on N-type voltage-dependent calcium channels, significantly shortened the licking time in the late phase of a formalin test.
authors.affiliation: Department of Molecular Pharmacology, Tohoku University School of Medicine, Seiryoumachi, Aoba-ku, Sendai 980-8575, Japan. mmura@mail.cc.tohoku.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Murakami
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: O
authors.initials: O
authors.lastname: Nakagawasai
authors.forename: H
authors.initials: H
authors.lastname: Murakami
authors.forename: S
authors.initials: S
authors.lastname: Murakami
authors.forename: A
authors.initials: A
authors.lastname: Esashi
authors.forename: R
authors.initials: R
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Yanagisawa
authors.forename: K
authors.initials: K
authors.lastname: Tan-No
authors.forename: I
authors.initials: I
authors.lastname: Miyoshi
authors.forename: H
authors.initials: H
authors.lastname: Sasano
authors.forename: T
authors.initials: T
authors.lastname: Tadano
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D020864:Calcium Channels, N-Type / Q000032:analysis* / Q000502:physiology; D005727:Ganglia, Spinal / Q000737:chemistry* / Q000166:cytology; D007278:Injections, Spinal; D051379:Mice; D009474:Neurons / Q000737:chemistry* / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D010147:Pain Measurement / Q000187:drug effects; D020960:omega-Conotoxins / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D020864:Calcium Channels, N-Type; D020960:omega-Conotoxins; C077380:omega-conotoxin SVIB