title: Novel HLA allele, HLA-B*4013, identified from a potential bone marrow recipient. Putative gene conversion events with donor sequence.
abstract: A new B40 allele was identified in a leukemic Caucasian patient. This allele, designated B*4013, differs in alpha 1 domain from B*4002 at six amino acidic positions: 67, 77, 80, 81, 82 and 83. Most of this substitutions could alter the antigen binding site of the HLA-B molecule. B*4013 may have originated by gene conversion or reciprocal recombination involving B*4002 as the recipient allele of sequence donated by B*4406. The new allele was serologically typed as a "blank" associated with the Bw4 epitope.
authors.affiliation: Laboratorio de Inmunogenética, Hospital de Clínicas, Universidad de Buenos Aires (UBA), Buenos Aires, Argentina.
authors.forename: P V
authors.initials: PV
authors.lastname: Blanco
authors.forename: G
authors.initials: G
authors.lastname: Theile
authors.forename: C
authors.initials: C
authors.lastname: Marcos
authors.forename: M
authors.initials: M
authors.lastname: Capucchio
authors.forename: N
authors.initials: N
authors.lastname: Lindel
authors.forename: L
authors.initials: L
authors.lastname: Sala
authors.forename: L
authors.initials: L
authors.lastname: Fainboim
authors.forename: M L
authors.initials: ML
authors.lastname: Satz
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D005260:Female; D005785:Gene Conversion / Q000276:immunology*; D015235:HLA-B Antigens / Q000235:genetics*; D059947:HLA-B40 Antigen; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics / Q000276:immunology / Q000628:therapy; D008297:Male; D008969:Molecular Sequence Data; D014019:Tissue Donors
chemical_list: D015235:HLA-B Antigens; C439540:HLA-B*40:13 antigen; D059947:HLA-B40 Antigen