Antiprotozoal activity of Neurolaena lobata.
Extracts, fractions and sesquiterpene lactones from Neurolaena lobata (L.) R. Br. (Asteraceae), a traditional medicinal plant from Guatemala, were tested in vitro against Leishmania spp. promastigotes, Trypanosoma cruzi trypomastigotes and epimastigotes and Trichomonas vaginalis trophozoites. The ethanol extract inhibited the parasite growth of L. mexicana, T. cruzi and T. vaginalis significantly. The pure germacranolides 1 and a mixture of 2 and 3, isolated from the ethonal extract, were highly active against L. mexicana and T. cruzi.
Berger
I
I
Institut für Pharmakognosie, Universität Wien, Pharmaziezentrum, Althanstrabetae 14, A-1090 Wien, Austria.
Passreiter
C M
CM
Cáceres
A
A
Kubelka
W
W
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D019659:Asteraceae; D056890:Eukaryota / Q000187:drug effects*; D006801:Humans; D007891:Leishmania / Q000187:drug effects; D021261:Parasitic Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology; D018515:Plant Leaves; D010946:Plants, Medicinal; D014246:Trichomonas vaginalis / Q000187:drug effects; D014349:Trypanosoma cruzi / Q000187:drug effects
D000981:Antiprotozoal Agents; D010936:Plant Extracts