A safety-catch linker for amine release under biologically compatible conditions.
A 'biocompatible' safety-catch linker based on an internal diketopiperazine release has been developed to allow the release of amine based compounds. The synthesis of the linker and its pre-loading with a representative set of amines is described. After immobilization onto an amino Tentagel resin, the linker was activated and the amines were released under biological conditions at pH 8.
Orain
D
D
Department of Chemistry, University of Southampton, Southampton SO17 1BJ, U.K.
Bradley
M
M
D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry; D001672:Biocompatible Materials / Q000138:chemical synthesis / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D020650:Combinatorial Chemistry Techniques / Q000379:methods*; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy
D000588:Amines; D001672:Biocompatible Materials