title: Adult perineal sarcomas.
abstract: OBJECTIVE
  Primary perineal sarcoma in adults is a rare disease that has only been documented to occur in isolated case reports.
  
  
  METHODS
  To better characterize and define the natural history of perineal sarcoma in adults (> or = 18 years), we reviewed our experience with treatment of perineal sarcoma between 1982 and 1999 (nine cases).
  
  
  RESULTS
  Epithelioid sarcoma (n = 4) was the most common histologic subtype. Seven cases (78%) were histologically high grade, and lesions were most commonly < 5 cm. All patients were treated with wide local excision. External beam radiation was the most commonly used form of adjuvant therapy (n = 6). Recurrences were noted in five patients, and the recurrences were most commonly local (60%). Median time to first recurrence was 21 months. Six of nine patients are alive with a median follow-up of 54 months. Three died of recurrent/metastatic disease at 16, 51, and 54 months after initial surgery.
  
  
  CONCLUSIONS
  Aggressive therapy and follow-up beginning with wide excision can be associated with long-term survival in adults with primary perineal sarcoma.
authors.affiliation: Department of Surgery, Memorial-Sloan Kettering Cancer Center, New York, New York, USA.
authors.forename: S R
authors.initials: SR
authors.lastname: Grobmyer
authors.forename: B
authors.initials: B
authors.lastname: Clary
authors.forename: J J
authors.initials: JJ
authors.lastname: Lewis
authors.forename: R
authors.initials: R
authors.lastname: Delgado
authors.forename: J M
authors.initials: JM
authors.lastname: Woodruff
authors.forename: M F
authors.initials: MF
authors.lastname: Brennan
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010502:Perineum / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D012509:Sarcoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*; D012983:Soft Tissue Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*