title: Uroguanylin level in umbilical cord blood.
abstract: BACKGROUND
  Uroguanylin is a novel natriuretic and diuretic peptide originally isolated from urine.
  
  
  METHODS
  To determine whether uroguanylin has a physiologic role during the perinatal period, uroguanylin levels in umbilical cord plasma obtained at the time of delivery were measured by radioimmunoassay and compared with cord serum osmolality.
  
  
  RESULTS
  Mean (+/- SD) cord plasma uroguanylin concentrations (8.8 +/- 2.1 fmol/mL) were higher compared with normal adult values. The extent of maturity, mode of delivery and gender did not appear to influence cord uroguanylin levels. The uroguanylin concentration had a significant positive correlation with cord serum osmolality.
  
  
  CONCLUSIONS
  These findings support some regulatory role of this peptide in perinatal renal and cardiovascular adaptation.
authors.affiliation: Department of Pediatrics, Fukui Medical University, Fukui, Japan. htsuka@fmsrsa.fukui-u.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Tsukahara
authors.forename: K
authors.initials: K
authors.lastname: Sekine
authors.forename: M
authors.initials: M
authors.lastname: Uchiyama
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: M
authors.initials: M
authors.lastname: Nakazato
authors.forename: Y
authors.initials: Y
authors.lastname: Date
authors.forename: W
authors.initials: W
authors.lastname: Tsunezawa
authors.forename: F
authors.initials: F
authors.lastname: Kotsuji
authors.forename: K
authors.initials: K
authors.lastname: Nishida
authors.forename: M
authors.initials: M
authors.lastname: Hiraoka
authors.forename: M
authors.initials: M
authors.lastname: Mayumi
mesh_terms: D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D007231:Infant, Newborn; D045265:Natriuretic Peptides; D009994:Osmolar Concentration; D010455:Peptides / Q000097:blood*
chemical_list: D045265:Natriuretic Peptides; D010455:Peptides; C084362:uroguanylin