[Concentration of transferrin iron and transferrin saturation in blood].
Transferrin iron, transferrin protein concentrations, and transferrin saturation have been determined for the first time in the whole blood. Microsamples were taken from healthy adults and patients with occupational secondary haemochromatosis using quantitative electron spin resonance technique. At elevated transferrin saturation, transferrin saturation values determined in the plasma and serum samples were shown to be less than respective values determined in the whole blood of the same patients. At increased transferrin iron concentration the difference between experimental and reference data sets determined in the blood and plasma was statistically significant in contrast to data sets determined in serum. Therefore, the analysis of the blood microsamples ensured an adequate estimation of transferrin iron concentration, especially at high transferrin saturation. A new index--transferrin iron concentration in the formed blood elements--was introduced. The values of the index were determined in the groups of healthy adults, patients with secondary occupational hemochromatosis and healthy newborns.
Dudchenko
N O
NO
Institute of Applied Problems in Physics and Biophysics, National Academy of Sciences of Ukraine.
Mykhaĭlyk
O M
OM
D000328:Adult; D016022:Case-Control Studies; D004578:Electron Spin Resonance Spectroscopy; D006432:Hemochromatosis / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007501:Iron / Q000097:blood*; D008875:Middle Aged; D012015:Reference Standards; D014168:Transferrin / Q000378:metabolism*
D014168:Transferrin; D007501:Iron