Molecular scaffold protein and cellular responses.
Mitogen-activated kinases (MAPK) regulate many diverse cellular processes, including growth, differentiation and responses to stress. The organization of MAPKs through the use of scaffolding proteins is crucial for the selective activation of these kinases by different stimuli. Recent studies identify beta-arrestins as members of the family of MAPK scaffold proteins. beta-Arrestins not only shut off signaling by uncoupling G-protein-coupled receptors (GPCRs) from their heterotrimeric G proteins, but also contribute to the specificity of GPCRs signaling by recruiting and activating selective MAPKs.
Keenan
S M
SM
Baldassare
J J
JJ
D000818:Animals; D019390:Arrestins / Q000378:metabolism*; D004789:Enzyme Activation; D020962:Heterotrimeric GTP-Binding Proteins / Q000378:metabolism; D020935:MAP Kinase Signaling System; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000378:metabolism; D000071557:beta-Arrestins
D019390:Arrestins; D011956:Receptors, Cell Surface; D000071557:beta-Arrestins; D020928:Mitogen-Activated Protein Kinases; D020962:Heterotrimeric GTP-Binding Proteins