title: Noise-induced hearing loss: the effect of melanin in the stria vascularis.
abstract: Conflicting investigations regarding the potential protective effect of melanin against noise-induced sensorineural hearing loss have suggested that eumelanin and pheomelanin may have differing effects within the stria vascularis. Three strains of C57BL/6J mice, (+/+, a/a) wild-types (dark coats/black eyes), (c2j/c2j, a/a), albinos (white coats/pink eyes), and (+/+, Ay/Ay) yellow mice (yellow coats/black eyes), were subjected to five consecutive days of broad band noise exposure at 112 dB(A) SPL for 3 h/day. Cochlear function was evaluated with auditory brainstem response audiometry to pure tones immediately pre-exposure, 5-6 h postexposure, and 14 days post-exposure. No significant difference in the degree of sensorineural hearing loss induced in the three strains of mice was identified. The eumelanin and pheomelanin content of each stria vascularis and amount of protein per stria for both mouse and guinea pig (2/NCR) were determined via high performance liquid chromatography. No pheomelanin was found in the stria of yellow mice, suggesting that coat color is not an accurate predictor of strial melanin content. The melanin content per mg of strial protein was higher in mice than in guinea pigs. A species-specific difference in melanin content does not explain the absence of a protective effect in mice.
authors: Department of Otolaryngology/Head and Neck Surgery, Oregon Hearing Research Center, Oregon Health Sciences University, Portland 97201-3098, USA.
authors: S
authors: S
authors: Bartels
authors: S
authors: S
authors: Ito
authors: D R
authors: DR
authors: Trune
authors: A L
authors: AL
authors: Nuttall
mesh_terms: D000818:Animals; D001309:Auditory Threshold; D005260:Female; D006317:Hearing Loss, Noise-Induced / Q000209:etiology* / Q000378:metabolism* / Q000503:physiopathology; D008543:Melanins / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D010858:Pigmentation; D013045:Species Specificity; D013316:Stria Vascularis / Q000378:metabolism* / Q000648:ultrastructure
chemical_list: D008543:Melanins