Cidofovir treatment of human polyomavirus-associated acute haemorrhagic cystitis.
We report the case of an 18-year-old patient who received an allogeneic bone marrow transplant from an HLA-identical unrelated donor for a Ph+ acute lymphoblastic leukemia, in his third complete remission. Cyclophosphamide and busulfan were used as conditioning treatment. Acute graft-versus-host disease developed on day +9, and the response to adequate treatment (steroids) was favourable. On day +45 the patient developed an acute severe haemorhragic cystitis, and BK polyomavirus was demonstrated in urine samples using electron microscopy and polymerase chain reaction. Urinary symptoms did not improve in spite of palliative treatment, but a response was evident after 2 weeks of cidofovir treatment.
González-Fraile
M I
MI
Servicio de Hematología, Hospital Clínico Universitario, Salamanca, Spain.
Cañizo
C
C
Caballero
D
D
Hernández
R
R
Vázquez
L
L
López
C
C
Izarra
A
A
Arroyo
J L
JL
de la Loma
A
A
Otero
M J
MJ
San Miguel
J F
JF
D000293:Adolescent; D000998:Antiviral Agents / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation / Q000009:adverse effects / Q000379:methods; D000077404:Cidofovir; D003556:Cystitis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D008297:Male; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D011120:Polyomavirus / Q000302:isolation & purification; D027601:Polyomavirus Infections / Q000175:diagnosis / Q000188:drug therapy*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy; D016896:Treatment Outcome; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000188:drug therapy*
D000998:Antiviral Agents; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir