title: Inhibitory effects of anti-inflammatory drugs on interleukin-6 bioactivity.
abstract: Interleukin-6 (IL-6) is known as a proinflammatory cytokine involved in immune response, inflammation, and hematopoiesis. Inhibitory effects of anti-inflammatory drugs on IL-6 bioactivity using IL-6-dependent hybridoma have been evaluated. Three out of 16 nonsteroidal anti-inflammatory drugs (NSAIDs) showed IC50 values of less than 100 microM, which were in the order of oxyphenylbutazone hydrate (IC50=7.5 microM)>meclofenamic acid sodium salt (31.9 microM)>sulindac (74.9 microM). Steroidal anti-inflammatory drugs (SAIDs) exhibited significant inhibitory effects at 100 microM on the IL-6 bioactivity, and their inhibitory potencies were in the order of budesonide (IC50=2.2 microM)>hydrocortisone 21-hemisuccinate (6.7 microM), prednisolone (7.5 microM), betamethasone (10.9 microM)>dexamethasone (18.9 microM) and triamcinolone acetonide (24.1 microM). The results would provide an additional mechanism by which anti-inflammatory drugs display their anti-inflammatory and immunosuppressive effects at higher concentrations.
authors: College of Pharmacy, Chungbuk National University, Cheongju, Korea.
authors: B S
authors: BS
authors: Kang
authors: E Y
authors: EY
authors: Chung
authors: Y P
authors: YP
authors: Yun
authors: M K
authors: MK
authors: Lee
authors: Y R
authors: YR
authors: Lee
authors: K S
authors: KS
authors: Lee
authors: K R
authors: KR
authors: Min
authors: Y
authors: Y
authors: Kim
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002460:Cell Line; D015850:Interleukin-6 / Q000502:physiology; D051379:Mice; D013256:Steroids; D000093242:Interleukin-6 Inhibitors
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D015850:Interleukin-6; D013256:Steroids; D000093242:Interleukin-6 Inhibitors