title: Pathological documentation of complete elimination of Barrett's metaplasia following endoscopic multipolar electrocoagulation therapy.
abstract: The previous paradigm that Barrett's is an irreversible premalignant lesion has recently been challenged by a proliferation of reports documenting elimination of Barrett's by a variety of endoscopic techniques. Whether Barrett's is entirely eliminated is unknown as endoscopic biopsy samples the surface of the epithelium only. Numerous reports document underlying specialised columnar epithelium in many of these trials. Until now there have been no reports of pathological examination of the entire oesophagus as a specimen. This case documents complete elimination of intestinal metaplasia from the oesophagus and supports the biological plausibility of these research techniques.
authors: Department of Medicine, Oregon Health Sciences University, Portland, Oregon, USA. fennerty@ohsu.edu
authors: M B
authors: MB
authors: Fennerty
authors: C L
authors: CL
authors: Corless
authors: B
authors: B
authors: Sheppard
authors: D O
authors: DO
authors: Faigel
authors: D A
authors: DA
authors: Lieberman
authors: R E
authors: RE
authors: Sampliner
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001471:Barrett Esophagus / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D017024:Chemotherapy, Adjuvant; D004564:Electrocoagulation / Q000379:methods*; D016629:Esophagectomy / Q000379:methods; D005764:Gastroesophageal Reflux / Q000150:complications / Q000601:surgery; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D009853:Omeprazole