Urine antipyrine metabolites in rats with different resistance to hypoxia subjected to cold stress.
We studied antipyrine metabolism in rats with different resistance to hypoxia during adaptation to cold stress. Changes in the concentrations of some antipyrine metabolites at low temperature were associated with individual resistance to hypoxia. In low-resistant rats, antipyrine metabolism was suppressed from day 5 of cold exposure to day 3 of the recovery period. In highly resistant rats, antipyrine metabolism was inhibited on day 3 of cold exposure, but returned to normal on day 3 of the recovery period.
Grek
O R
OR
Department of Pharmacology, Novosibirsk Medical Academy. nikagrek@sibnet.ru
Guseva
E O
EO
Gichev
Y P
YP
Sharapov
V I
VI
D000222:Adaptation, Physiological; D000818:Animals; D000983:Antipyrine / Q000652:urine*; D003080:Cold Temperature; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013312:Stress, Physiological / Q000503:physiopathology / Q000652:urine*
D000983:Antipyrine