title: Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.
abstract: t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.
authors: Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors: Z
authors: Z
authors: Ma
authors: S W
authors: SW
authors: Morris
authors: V
authors: V
authors: Valentine
authors: M
authors: M
authors: Li
authors: J A
authors: JA
authors: Herbrick
authors: X
authors: X
authors: Cui
authors: D
authors: D
authors: Bouman
authors: Y
authors: Y
authors: Li
authors: P K
authors: PK
authors: Mehta
authors: D
authors: D
authors: Nizetic
authors: Y
authors: Y
authors: Kaneko
authors: G C
authors: GC
authors: Chan
authors: L C
authors: LC
authors: Chan
authors: J
authors: J
authors: Squire
authors: S W
authors: SW
authors: Scherer
authors: J K
authors: JK
authors: Hitzler
mesh_terms: D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*; D008969:Molecular Sequence Data; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D015534:Trans-Activators; D014178:Translocation, Genetic
chemical_list: D004268:DNA-Binding Proteins; C431575:MRTFA protein, human; D015514:Oncogene Proteins, Fusion; C431574:RBM15 protein, human; D016601:RNA-Binding Proteins; D015534:Trans-Activators