title: IgE-mediated occupational asthma induced by herbal medicine, Banha (Pinellia ternata).
abstract: There have been few reported cases of occupational asthma induced by Pinellia ternata (Banha), and the mechanism responsible for this type of asthma is still undetermined. We report a case of Banha-induced occupational asthma with IgE-mediated mechanism. The patient had positive skin responses to Banha extract and Banha-specific bronchial challenge elicited an early asthmatic response. The serum-specific IgE binding to Banha extract was detectable and completely inhibited with the additions of 0.1 microg/mL of Banha extract on ELISA inhibition. Seven IgE binding components to Banha extract (6.5, 22, 24, 32, 34, and 48 kDa) were detected using SDS-PAGE and immunoblot analysis. In conclusion, the results of this study suggest that P. ternata (Banha)-derived allergens are able to cause IgE-mediated bronchoconstriction in exposed workers.
authors: Department of Internal Medicine, Seoul National University College of Medicine, 28 Yongon-dong, Chongno-gu, Seoul 110-744, Korea.
authors: S H
authors: SH
authors: Kim
authors: H
authors: H
authors: Jeong
authors: Y K
authors: YK
authors: Kim
authors: S H
authors: SH
authors: Cho
authors: K U
authors: KU
authors: Min
authors: Y Y
authors: YY
authors: Kim
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000209:etiology; D029001:Herbal Medicine; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*; D037102:Lectins / Q000009:adverse effects*; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D037121:Plant Lectins
chemical_list: D037102:Lectins; C047938:Pinellia ternata lectin; D037121:Plant Lectins