Cellular effects of 5-formyluracil in DNA.
5-Formyluracil is a major oxidation product of thymine, formed in DNA in yields comparable to that of 8-oxo-7,8-dihydroguanine by exposure to gamma-irradiation. Whereas the repair pathways for removal and the biological effects of persisting 8-oxo-7,8-dihydroguanine are much elucidated, much less attention has been paid to the cellular implications of 5-formyluracil in DNA. Here we review the present state of knowledge in this important area within research on oxidative DNA damage.
Bjelland
S
S
School of Science and Technology, Stavanger University College, Ullandhaug, P.O. Box 2557, N-4091 Stavanger, Oslo, Norway. svein.bjelland@tn.his.no
Anensen
H
H
Knaevelsrud
I
I
Seeberg
E
E
D020137:Base Pair Mismatch; D004249:DNA Damage; D004260:DNA Repair; D009153:Mutagens / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity; D010084:Oxidation-Reduction; D014498:Uracil / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism* / Q000633:toxicity
D009153:Mutagens; C007777:5-formyluracil; D014498:Uracil