Synthesis and biological activity of glycosyl conjugates of N-(4-hydroxyphenyl)retinamide.
Three glycosyl (glucosyl, galactosyl, mannosyl) conjugates of 4-hydroxyphenylretinamide have been synthesized and tested on a broad variety of tumor cells. All three compounds are active on promyelocytic leukemia cell lines HL60 but less than the parent compound 4-HPR. Among them, the mannosyl analog stands out by its very low toxicity.
Winum
J Y
JY
Laboratoire de Chimie Biomoléculaire, Synthèse et Développement de Composes d'Intérêt Biologique, UMR 5032, Université Montpellier II-CNRS-Mayoly Spindler, France.
Leydet
A
A
Seman
M
M
Montero
J L
JL
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005347:Fibroblasts / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009000:Monocytes / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D007202:Indicators and Reagents