title: Influence of hepatitis C virus on the profiles of patients with chronic hepatitis B virus infection.
abstract: BACKGROUND
  Hepatitis B virus (HBV) and hepatitis C virus (HCV) are the most common causes of chronic liver disease, cirrhosis and hepatocellular carcinoma. The influence of HCV infection on the clinicopathological and virological profiles of chronic HBV infection was investigated.
  
  
  METHODS
  A total of 100 chronic HBV carriers with histopathological diagnoses by liver biopsy were studied. Hepatitis B e antigen (HBeAg) and anti-HCV antibody were tested. Serum HCV-RNA was detected by using a nested reverse transcription-PCR assay. A branched DNA (bDNA) assay was used to detect HBV-DNA and quantitate the serum levels.
  
  
  RESULTS
  Eighteen (18%) of 100 patients were positive for anti-HCV and HCV-RNA. Patients with concurrent HCV and HBV infection were significantly older than those without HCV infection (P < 0.05). The positive rates of HBeAg and HBV-DNA as well as the serum levels of HBV-DNA in patients with concurrent HCV and HBV infection were significantly lower than those without concurrent HCV and HBV infection (P < 0.01, P < 0.05, and P < 0.001, respectively). By using multivariate analysis, the factors of seroconversion of HBeAg and decreasing level of HBV-DNA were significantly correlated to concurrent HCV and HBV infection in chronic HBV carriers. The factors of increasing age and concurrent HCV and HBV infection were significantly correlated to seroconversion of HBeAg.
  
  
  CONCLUSIONS
  The concurrent HCV and HBV infection in chronic HBV carriers might result in a suppression of HBV replication that presented with a lower level of serum HBV-DNA and HBeAg seroconversion. Nevertheless, neither more obvious increase in biochemical parameters nor histopathological progression to more advanced liver diseases was observed.
authors: Hepatobiliary Division, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan, Republic of China.
authors: C Y
authors: CY
authors: Dai
authors: M L
authors: ML
authors: Yu
authors: W L
authors: WL
authors: Chuang
authors: Z Y
authors: ZY
authors: Lin
authors: S C
authors: SC
authors: Chen
authors: M Y
authors: MY
authors: Hsieh
authors: L Y
authors: LY
authors: Wang
authors: J F
authors: JF
authors: Tsai
authors: W Y
authors: WY
authors: Chang
mesh_terms: D000328:Adult; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D016174:Hepacivirus / Q000235:genetics* / Q000276:immunology; D006510:Hepatitis B Antibodies; D006515:Hepatitis B virus / Q000235:genetics* / Q000276:immunology; D019694:Hepatitis B, Chronic / Q000150:complications* / Q000821:virology; D006526:Hepatitis C / Q000150:complications*; D018937:Hepatitis C Antibodies; D006801:Humans; D016015:Logistic Models; D008297:Male; D015999:Multivariate Analysis; D012367:RNA, Viral / Q000032:analysis; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D018937:Hepatitis C Antibodies; D012367:RNA, Viral