Effect of omeprazole on the pharmacokinetics of sustained-release carbamazepine in healthy male volunteers.
The present study shows the effect of omeprazole administration on the pharmacokinetics of a sustained-release preparation of carbamazepine in healthy male volunteers. Multiple dose administration of omeprazole increased the Cmax, AUC0-infinity and elimination half life (t1/2e) of carbamazepine. The results suggest that drug monitoring should be carried out when carbamazepine is coadministered with omeprazole.
Dixit
R K
RK
Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Chawla
A B
AB
Kumar
N
N
Garg
S K
SK
D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D000927:Anticonvulsants / Q000097:blood / Q000493:pharmacokinetics*; D019540:Area Under Curve; D002220:Carbamazepine / Q000097:blood / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000494:pharmacology*
D000897:Anti-Ulcer Agents; D000927:Anticonvulsants; D003692:Delayed-Action Preparations; D002220:Carbamazepine; D009853:Omeprazole