Multiple genes for the last step of proline biosynthesis in Bacillus subtilis.
The complete Bacillus subtilis genome contains four genes (proG, proH, proI, and comER) with the potential to encode Delta(1)-pyrroline-5-carboxylate reductase, a proline biosynthetic enzyme. Simultaneous defects in three of these genes (proG, proH, and proI) were required to confer proline auxotrophy, indicating that the products of these genes are mostly interchangeable with respect to the last step in proline biosynthesis.
Belitsky
B R
BR
Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111, USA. bbelit02@tufts.edu
Brill
J
J
Bremer
E
E
Sonenshein
A L
AL
D001119:Arginase / Q000378:metabolism; D001412:Bacillus subtilis / Q000201:enzymology*; D005798:Genes, Bacterial; D016296:Mutagenesis; D011392:Proline / Q000096:biosynthesis*; D011762:Pyrroline Carboxylate Reductases / Q000235:genetics / Q000502:physiology*; D000097502:delta-1-Pyrroline-5-Carboxylate Reductase
D001119:Arginase; D011392:Proline; D011762:Pyrroline Carboxylate Reductases; D000097502:delta-1-Pyrroline-5-Carboxylate Reductase