title: Amotivational syndrome associated with selective serotonin reuptake inhibitors in children and adolescents.
abstract: A frontal lobe syndrome has previously been reported in adults treated with selective serotonin reuptake inhibitors (SSRIs), but not in children. Five typical cases of apathy and lack of motivation, one accompanied by disinhibition, are described in a child and four adolescents. Symptoms were dose related and reversible. The subtlety of symptoms, lack of insight in patients, disabling effects, and delayed onset indicate a need for clinicians to inform families of these potential symptoms when SSRIs are prescribed.
authors: University of British Columbia, Mood and Anxiety Disorders Clinic, British Columbia's Children's Hospital, Vancouver Community Mental Health Service, Canada. jgarland@cw.bc.ca
authors: E J
authors: EJ
authors: Garland
authors: E A
authors: EA
authors: Baerg
mesh_terms: D000293:Adolescent; D001008:Anxiety Disorders / Q000188:drug therapy / Q000523:psychology; D002648:Child; D003866:Depressive Disorder / Q000188:drug therapy / Q000523:psychology; D005260:Female; D005473:Fluoxetine / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009042:Motivation; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy; D017374:Paroxetine / Q000009:adverse effects / Q000627:therapeutic use; D017367:Selective Serotonin Reuptake Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D005473:Fluoxetine; D017374:Paroxetine; D017367:Selective Serotonin Reuptake Inhibitors