Intestinal dysfunction in liver cirrhosis: Its role in spontaneous bacterial peritonitis.
Spontaneous bacterial peritonitis is a common illness in patients with cirrhosis and ascites that occurs without any apparent focus of infection. Bacterial translocation plays an important role in spontaneous bacterial peritonitis and it is evident from a variety of studies that the gut is a major source of this bacteria. Gut motility alterations, along with bacterial overgrowth and changes in intestinal permeability, probably play a role in this bacterial translocation. The present review looks at the role of the intestine in spontaneous bacterial peritonitis induced by liver cirrhosis and the factors influencing bacterial translocation in this disease.
Ramachandran
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The Wellcome Trust Research Laboratory, Department of Gastrointestinal Sciences, Christian Medical College and Hospital, Vellore, India.
Balasubramanian
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KA
D000818:Animals; D001424:Bacterial Infections / Q000209:etiology; D018988:Bacterial Translocation; D002463:Cell Membrane Permeability; D005609:Free Radicals; D005769:Gastrointestinal Motility; D006801:Humans; D007422:Intestines / Q000382:microbiology / Q000503:physiopathology*; D008103:Liver Cirrhosis / Q000150:complications* / Q000503:physiopathology; D018384:Oxidative Stress; D010538:Peritonitis / Q000209:etiology* / Q000382:microbiology; D013152:Splanchnic Circulation
D005609:Free Radicals