title: Interpretative criteria and quality control parameters for telithromycin disc diffusion susceptibility tests.
abstract: In vitro studies were carried out with 4175 Gram-positive clinical isolates, comparing telithromycin broth microdilution MICs with disc diffusion zone diameters. Provisional interpretive criteria for testing staphylococci were > or =23 mm for susceptible and < or =19 mm for resistant. Because pneumococci and other streptococci require increased CO(2), the corresponding zone sizes are 3 mm smaller (> or =20 mm and < or =16 mm). Two collaborative studies were performed in order to propose the following quality control limits: 24-30 mm for Staphylococcus aureus ATCC 25923 and 27-33 mm for Streptococcus pneumoniae ATCC 49619.
authors: The Clinical Microbiology Institute, 9725 SW Commerce Circle, Wilsonville, OR 97070, USA. cmi@hevanet.com
authors: A L
authors: AL
authors: Barry
authors: P C
authors: PC
authors: Fuchs
authors: S D
authors: SD
authors: Brown
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004058:Diffusion; D048628:Ketolides; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D011786:Quality Control; D013211:Staphylococcus aureus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects
chemical_list: D000900:Anti-Bacterial Agents; D048628:Ketolides; D018942:Macrolides; C106791:telithromycin