Novel polymorphisms in human macrophage inflammatory protein-1 alpha (MIP-1alpha) gene.
Human macrophage inflammatory protein-1 alpha (MIP-1alpha) is a chemotactic cytokine, which binds to macrophages, T cells, and B cells affecting their activation. We found novel polymorphisms at four sites within MIP-1alpha gene in Japanese population: C to T in exon 2; A to G in intron 2; C to G and A to G in exon 3. They occurred on the same allele. Although MIP-1alpha effectively suppresses the replication of HIV-1 in vitro, we observed no statistically significant difference in the allele frequency of this polymorphism between HIV-1-infected and uninfected individuals in Japanese population. Since an increased transcription level of MIP-1alpha has been reported to be associated with inflammatory diseases such as atopic dermatitis, we also investigated the frequency of these polymorphisms among patients with atopic dermatitis, HIV-1-infected individuals (with a normal IgE level), and healthy donors. A small increase in ratio of homozygotes to other genotypes was observed in patients with atopic dermatitis (P = 0.04).
Xin
X
X
Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Nakamura
K
K
Liu
H
H
Nakayama
E E
EE
Goto
M
M
Nagai
Y
Y
Kitamura
Y
Y
Shioda
T
T
Iwamoto
A
A
D000483:Alleles; D044466:Asian People / Q000235:genetics*; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D003876:Dermatitis, Atopic / Q000235:genetics*; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics; D015497:HIV-1; D006801:Humans; D007564:Japan; D019402:Macrophage Inflammatory Proteins / Q000235:genetics*
D054405:Chemokine CCL3; D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins