Effects of vitamin B12 on bright light on cognitive and sleep-wake rhythm in Alzheimer-type dementia.
The present study investigated the effects of vitamin B12 (VB12) on circadian rhythm in Alzheimer-type dementia (ATD). Twenty-eight ATD patients were treated with bright light therapy (BLT) for 8 weeks. For the latter 4 weeks, half were treated with VB12 with BLT (BLT + VB12). We evaluated the cognitive state with Mini-Mental State Examination and the circadian rhythm with actigraphy after the fourth and eighth week. After the first 4 weeks BLT improved the circadian rhythm disturbances and cognitive state especially in the early stage of ATD. Although the latter 4 week-BLT caused no significant effects on the circadian rhythm; BLT + VB12 improved the vigilance level during the daytime. These results suggest that VB12 has some efficiency to enhance vigilance for ATD patients.
Ito
T
T
Department of Neuropsychiatry, Nippon Medical School, Tama Nagayama Hospital, Tokyo, Japan. itohtakao/psych@nms.ac.jp
Yamadera
H
H
Ito
R
R
Suzuki
H
H
Asayama
K
K
Endo
S
S
D000368:Aged; D000544:Alzheimer Disease / Q000150:complications*; D001143:Arousal / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects; D003072:Cognition Disorders / Q000175:diagnosis* / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D010789:Phototherapy; D012720:Severity of Illness Index; D020178:Sleep Disorders, Circadian Rhythm / Q000150:complications* / Q000628:therapy*; D014805:Vitamin B 12 / Q000494:pharmacology / Q000627:therapeutic use*
D014805:Vitamin B 12