Kissing cousins: immunological and neurological synapses.
Immunological synapse formation is essential for T cell activation. A recent paper in Science reports that immunological and neurological synapses utilize a common molecule, agrin.
Shaw
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Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, Saint Louis, MO 63110, USA. shaw@immunology.wustl.edu
Allen
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PM
D048868:Adaptor Proteins, Signal Transducing; D018171:Agrin / Q000235:genetics / Q000276:immunology* / Q000378:metabolism; D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D003598:Cytoskeletal Proteins; D009469:Neuromuscular Junction / Q000378:metabolism; D011506:Proteins / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D013569:Synapses; D013601:T-Lymphocytes / Q000276:immunology*
D048868:Adaptor Proteins, Signal Transducing; D018171:Agrin; C114545:CD2-associated protein; D003598:Cytoskeletal Proteins; D011506:Proteins; D011948:Receptors, Antigen, T-Cell