title: Flexible two-stage designs: an overview.
abstract: In this overview we introduce the basic ideas behind a new flexible approach in sequential designs. The different concepts based on two-stage combination tests and conditional error functions are brought together. We sketch the construction of p-values, confidence intervals, and median unbiased estimates. Finally, recursive combination tests are introduced which extend the flexibility to the choice of the number of interim analyses.
authors: Department of Medical Statistics, University of Vienna. peter.bauer@univie.ac.at
authors: P
authors: P
authors: Bauer
authors: W
authors: W
authors: Brannath
authors: M
authors: M
authors: Posch
mesh_terms: D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D003661:Decision Support Techniques; D006801:Humans; D008432:Mathematical Computing; D008492:Medical Informatics Computing; D010865:Pilot Projects; D012107:Research Design / Q000706:statistics & numerical data*