title: [Neonatal arteriovenous thrombosis: report of a case].
abstract: Limb vascular thrombosis is a severe, rare entity, often needing invasive surgery and sometimes leading to loss of function. An infant with in utero arteiro-venous thrombosis is reported.
  
  
  METHODS
  The baby, a female infant, was born at 34 weeks from a mother affected by gestational diabetes. She was referred to Neonatal Care Unit because of mild respiratory distress syndrome. She had no malformations. Spontaneous acute ischemia of right upper limb was noticed soon after admission: the limb appeared pale, cold, atonic and areflexic; no signs were noticed on it. Axillary artery and vein thromboses were soon confirmed by ultrasonography and arteriography. Intravenous administration of recombinant tissue plasminogen activator was carried on for 36 hours and followed by heparin and antithrombin III administration. Partial revascularization was obtained after a few hours: at the beginning of the treatment the limb became cyanotic, then edematous and finally the normal colour appeared everywhere but in the hand, was it became visible after a few days, when edema was reabsorbed. No recurrence of thrombosis occurred with heparin prophylaxis. Pain was treated with analgesic therapy, and motor impairment required physiotherapy. The doppler ultrasonographies which were performed subsequently confirmed a complete revascularization of axillary artery and vein. Coagulation and metabolic parameters (clotting tests, protein C, protein S, prothrombin, aminoacids) were studied but disorders predisposing to thrombosis were not found both in the patient and in her parents.
  
  
  CONCLUSIONS
  Early identification of limb vascular thrombosis through external symptoms is very important, as it can avoid invasive surgical procedures.
authors: Cattedra di Neonatologia, Università di Torino. bagna@pediatria.unito.it
authors: R
authors: R
authors: Bagna
authors: P
authors: P
authors: Tonetto
authors: S
authors: S
authors: Borgione
authors: S
authors: S
authors: Garbarini
authors: A
authors: A
authors: Mammano
authors: E
authors: E
authors: Bertino
authors: P
authors: P
authors: Murru
authors: L
authors: L
authors: Cavo
authors: C
authors: C
authors: Fabris
authors: G
authors: G
authors: Barattia
authors: P
authors: P
authors: Saracco
mesh_terms: D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D013927:Thrombosis / Q000175:diagnosis*