Cell proliferation and protein synthesis as initial factors in determination of axial polarity.
The rate of cell proliferation relative to that of protein synthesis appears to have an initial role in establishment of axial polarities in developing animal embryos. An increase in this ratio leads to anterior or dorsal differentiation, while reduction allows posterior or ventral differentiation in a number of organisms. The role that various growth factors play in the regulation of proliferation and protein synthesis is examined.
Flickinger
R A
RA
Department of Biological Sciences, State University of New York, Buffalo, New York 14260, USA. raf53@hotmail .com
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002455:Cell Division; D004622:Embryo, Mammalian / Q000502:physiology*; D004625:Embryo, Nonmammalian; D006133:Growth Substances / Q000494:pharmacology; D014176:Protein Biosynthesis
D006133:Growth Substances