Pregnancy after cytoplasmic transfer in a couple suffering from idiopathic infertility: case report.
Couples suffering from idiopathic infertility are among the most difficult to treat in IVF cycles due to the unknown cause of failure to reproduce. This can lead to years of unsuccessful attempts to conceive and often the abandonment of treatment. In some couples, the only observable problem is the development of poor quality embryos. In this case report, we describe the successful use of cytoplasmic donation in a couple where the high level of embryo fragmentation and poor embryo development was thought to be the unique cause of failure to conceive after intracytoplasmic sperm injection (ICSI). We noted a strong reduction in embryo fragmentation and a consequent increase in embryo quality after the treatment. Transfer of four of the embryos receiving donor cytoplasm led to a pregnancy with two gestational sacs and the birth of healthy twins.
Dale
B
B
Centre for Reproductive Biology, Clinica Villa Del Sole, Via Manzoni 15, 80123 Naples, Italy. dale@interfree.it
Wilding
M
M
Botta
G
G
Rasile
M
M
Marino
M
M
Di Matteo
L
L
De Placido
G
G
Izzo
A
A
D000328:Adult; D046508:Culture Techniques; D003593:Cytoplasm / Q000637:transplantation*; D004624:Embryo Transfer; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage; D006801:Humans; D007246:Infertility / Q000628:therapy*; D008297:Male; D018587:Oocyte Donation; D009865:Oocytes / Q000648:ultrastructure*; D010062:Ovulation Induction; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic; D014427:Twins
D005640:Follicle Stimulating Hormone