title: Il-6 and its soluble receptor orchestrate a temporal switch in the pattern of leukocyte recruitment seen during acute inflammation.
abstract: During acute inflammation, leukocyte recruitment is characterized by an initial infiltration of neutrophils, which are later replaced by a more sustained population of mononuclear cells. Based on both clinical and experimental evidence, we present a role for IL-6 and its soluble receptor (sIL-6R) in controlling this pattern of leukocyte recruitment during peritoneal inflammation. Liberation of sIL-6R from the initial neutrophil infiltrate acts as a regulator of CXC and CC chemokine expression, which contributes to a suppression of neutrophil recruitment and the concurrent attraction of mononuclear leukocytes. Soluble IL-6R-mediated signaling is therefore an important intermediary in the resolution of inflammation and supports transition between the early predominantly neutrophilic stage of an infection and the more sustained mononuclear cell influx.
authors: Cardiff School of Biosciences, Cardiff University, Cardiff CF10 3US, Wales, United Kingdom.
authors: S M
authors: SM
authors: Hurst
authors: T S
authors: TS
authors: Wilkinson
authors: R M
authors: RM
authors: McLoughlin
authors: S
authors: S
authors: Jones
authors: S
authors: S
authors: Horiuchi
authors: N
authors: N
authors: Yamamoto
authors: S
authors: S
authors: Rose-John
authors: G M
authors: GM
authors: Fuller
authors: N
authors: N
authors: Topley
authors: S A
authors: SA
authors: Jones
mesh_terms: D000818:Animals; D001202:Ascitic Fluid; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D018932:Chemokine CCL2 / Q000096:biosynthesis; D004195:Disease Models, Animal; D004848:Epithelium; D006801:Humans; D015850:Interleukin-6 / Q000235:genetics / Q000276:immunology*; D007676:Kidney Failure, Chronic / Q000276:immunology*; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D010537:Peritoneum / Q000166:cytology; D010538:Peritonitis / Q000276:immunology*; D019947:Receptors, Interleukin-6 / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D012995:Solubility
chemical_list: D018932:Chemokine CCL2; D015850:Interleukin-6; D019947:Receptors, Interleukin-6