Is there a place for different isoforms of FSH in clinical medicine? IV. The clinician's point of view.
Follicle stimulating hormone (FSH) plays an important role in gametogenesis in both men and women. In men it is required for the establishment and probably maintenance of spermatogenesis. In women it stimulates the growth of ovarian follicles and fluctuations in its secretion are involved in the selection of the ovulatory follicle. It is now possible by recombinant DNA technology to synthesize a range of isoforms of FSH with differing biological action and half-life which would provide a greater degree of flexibility in the treatment of women with anovulatory infertility. Longer acting isoforms of FSH would find clinical application in the treatment of hypogonadotrophic men.
Baird
D T
DT
Centre for Reproductive Biology, University of Edinburgh, 37 Chalmers Street, Edinburgh, EH3 9ET, UK. dtbaird@ed.ac.uk
D005260:Female; D005640:Follicle Stimulating Hormone / Q000737:chemistry* / Q000502:physiology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D010062:Ovulation Induction; D011994:Recombinant Proteins / Q000737:chemistry / Q000627:therapeutic use; D012099:Reproductive Techniques; D013091:Spermatogenesis
D011994:Recombinant Proteins; D005640:Follicle Stimulating Hormone