Effect of ionic carbohydrate-containing biopolymers on complement activation.
We studied in vitro effects of charged polysaccharides on the classic and alternative pathways of complement activation. The complement system was affected by substances having different charges. Our findings suggest that the conformation of polysaccharide molecules, but not their charge, plays a primary role in the interaction with C1 and C3 complement components followed by initiation of cascade enzymatic reactions.
Nazarova
I V
IV
Institute of Sea Biology, Far-Eastern Division of the Russian Academy of Sciences, Vladivostok.
Khotimchenko
Y S
YS
Shevchenko
N M
NM
Gorbach
V I
VI
Luk'yanov
P A
PA
D001704:Biopolymers / Q000737:chemistry / Q000494:pharmacology*; D002241:Carbohydrates / Q000032:analysis*; D003167:Complement Activation; D003172:Complement C1 / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D066298:In Vitro Techniques; D007477:Ions
D001704:Biopolymers; D002241:Carbohydrates; D003172:Complement C1; D003176:Complement C3; D007477:Ions