Beta-integrin of Anopheles gambiae: mRNA cloning and analysis of structure and expression.
We have isolated an mRNA encoding a beta integrin subunit of the malaria mosquito Anopheles gambiae. Our analysis predicts a protein that is very similar to betaPS, the fruitfly orthologue. The gene is expressed during all developmental stages and it is found in all body parts, including the midgut. Finally, the expression of the gene does not seem to be modulated during blood meals, except for a substantial increase 48 h posthaematophagy, when digestion is nearly complete.
Mahairaki
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V
Institute of Molecular Biology and Biotechnology, Foundation for Research and Technology-Hellas, 711 10 Heraklion, Crete, Greece.
Lycett
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G
Blass
C
C
Louis
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C
D000595:Amino Acid Sequence; D000818:Animals; D000852:Anopheles / Q000235:genetics*; D001483:Base Sequence; D018821:CD18 Antigens / Q000235:genetics; D003001:Cloning, Molecular; D018076:DNA, Complementary; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics; D015870:Gene Expression; D020869:Gene Expression Profiling; D019476:Insect Proteins / Q000235:genetics*; D039001:Integrin alpha Chains; D039641:Integrin beta Chains; D019012:Integrin beta1 / Q000235:genetics; D016023:Integrins / Q000235:genetics*; D008969:Molecular Sequence Data; D012333:RNA, Messenger; D017386:Sequence Homology, Amino Acid
D018821:CD18 Antigens; D018076:DNA, Complementary; D029721:Drosophila Proteins; D019476:Insect Proteins; D039001:Integrin alpha Chains; D039641:Integrin beta Chains; D019012:Integrin beta1; D016023:Integrins; D012333:RNA, Messenger; C435744:bint1 protein, Anopheles; C082188:if protein, Drosophila