title: [Reference values of growth hormone binding protein (GHBP) for a normal pediatric population].
abstract: Circulating concentrations of the high affinity growth hormone binding protein (GHBP) may be a marker of GH receptor density as well as GH sensitivity.
  
  
  OBJECTIVE
  To determine values of GHBP for a normal Chilean pediatric population.
  
  
  METHODS
  We determined GHBP levels in 73 males and 73 females between 4 to 15.5 years and 4 to 16.8 years respectively, divided in 7 groups according to age and puberal status.
  
  
  RESULTS
  The population was normally distributed in weight, height and body mass index (BMI). GHBP activity increased up to Tanner IV in males and Tanner III in females, and decreased slightly thereafter in Tanner V and IV respectively. There was a significant difference between GHBP levels of preschool children and those found in Tanner II to V in both sexes (p < 0.05). In addition, we found a positive correlation between GHBP vs weight, height and BMI (p < 0.001) in males and females.
  
  
  CONCLUSIONS
  The availability of this methodology allows us to establish the normative value of GHBP in our population and provides useful information to interpret GH circulating levels in children with growth disorders.
authors: Instituto de Investigaciones Materno Infantil (IDIMI), Facultad de Medicina, Universidad de Chile. uniendo@canela.med.uchile.cl
authors: T E
authors: TE
authors: Salazar
authors: M V
authors: MV
authors: Méricq
authors: M
authors: M
authors: Espinoza
authors: G
authors: G
authors: Iñiguez
authors: P
authors: P
authors: de Carvallo
authors: F
authors: F
authors: Cassorla
mesh_terms: D000293:Adolescent; D015415:Biomarkers / Q000097:blood; D001827:Body Height; D015992:Body Mass Index; D001835:Body Weight; D002352:Carrier Proteins / Q000097:blood* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D012016:Reference Values
chemical_list: D015415:Biomarkers; D002352:Carrier Proteins; C051815:somatotropin-binding protein