title: Small-fiber dysfunction in trigeminal neuralgia: carbamazepine effect on laser-evoked potentials.
abstract: BACKGROUND
  In patients with trigeminal neuralgia, results of clinical examination of sensory function are normal. Reflex and evoked potential studies have already provided information on large-afferent (non-nociceptive) function. Using laser-evoked potentials (LEP), the authors sought information on small-afferent (nociceptive) function.
  
  
  METHODS
  The brain potentials evoked by CO(2)-laser pulses directed to the perioral and supraorbital regions were studied in 67 patients with idiopathic or symptomatic trigeminal neuralgia and 30 normal subjects. Of the 67 patients, 49 were receiving carbamazepine.
  
  
  RESULTS
  All patients with symptomatic and 51% of those with idiopathic trigeminal neuralgia had frankly abnormal LEP on the painful side. The mean latency was significantly higher and mean amplitude lower on the painful than the nonpainful side. However, even on the nonpainful side, the mean latency was significantly longer than that of the age-matched controls. The nonpainful-side latency correlated significantly with the carbamazepine dose.
  
  
  CONCLUSIONS
  LEP detect severe impairment of the nociceptive afferent system on the painful side of patients with idiopathic as well as symptomatic trigeminal neuralgia. A dysfunction of small-myelinated afferents may play an important role in the pathophysiology of neuralgic pain. Carbamazepine markedly dampens these brain potentials. The authors propose that this effect may result from inhibition of nociceptive transmission in the cingulate gyrus.
authors: Department of Neurological Sciences, University La Sapienza, Roma, Italy. cruccu@uniroma1.it
authors: G
authors: G
authors: Cruccu
authors: M
authors: M
authors: Leandri
authors: G D
authors: GD
authors: Iannetti
authors: A
authors: A
authors: Mascia
authors: A
authors: A
authors: Romaniello
authors: A
authors: A
authors: Truini
authors: F
authors: F
authors: Galeotti
authors: M
authors: M
authors: Manfredi
mesh_terms: D000344:Afferent Pathways / Q000187:drug effects / Q000503:physiopathology; D000368:Aged; D000369:Aged, 80 and over; D002220:Carbamazepine / Q000627:therapeutic use*; D005071:Evoked Potentials / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D007834:Lasers; D008875:Middle Aged; D009413:Nerve Fibers, Myelinated / Q000187:drug effects* / Q000502:physiology*; D014277:Trigeminal Neuralgia / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D002220:Carbamazepine