[Modeling of K+ATP channel activity in normotensive and hypertensive animals].
It was shown that vasodilatory effects of ATP-sensitive potassium channels opener--flocalin--depend from character of increase of initial vessel tone. Norepinephrine and angiotensin II partially inhibit effects of flocalin, thus they depressed of KATP channel activity. The inhibitory effect of angiotensin II increases under arterial hypertension conditions. It was shown that vasodilatory effects of flocalin significantly do not distinguish in experiments on normotensive and hypertensive rats under K(+)-depolarization conditions. While the vasodilatory effects acetylcholine on hypertensive rats are significantly diminished. These data suggests that flocalin could be a perspective substance for treatment of hypertension.
Strutynsk'kyĭR
B
B
A.A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Moĭbenko
O O
OO
D000109:Acetylcholine / Q000378:metabolism; D000804:Angiotensin II / Q000378:metabolism*; D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D006168:Guinea Pigs; D006973:Hypertension / Q000378:metabolism* / Q000503:physiopathology*; D009130:Muscle, Smooth / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D015221:Potassium Channels / Q000502:physiology*
D015221:Potassium Channels; D000804:Angiotensin II; D000109:Acetylcholine; D009638:Norepinephrine