Biphenyls as surrogates of the steroidal backbone. Part 1: synthesis and estrogen receptor affinity of an original series of polysubstituted biphenyls.
In the course of a programme aimed at discovering new ligands of the estrogen receptor, we explored a series of substituted biphenyls. Their synthesis and binding affinity are described.
Lesuisse
D
D
Medicinal Chemistry, Aventis, 102 route de Noisy, 93235 Cedex, Romainville, France. dominique.lesuisse@aventis.com
Albert
E
E
Bouchoux
F
F
Cérède
E
E
Lefrançois
J M
JM
Levif
M O
MO
Tessier
S
S
Tric
B
B
Teutsch
G
G
D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D047628:Estrogen Receptor alpha; D006801:Humans; D011960:Receptors, Estrogen / Q000187:drug effects*; D011994:Recombinant Proteins / Q000187:drug effects; D013256:Steroids / Q000737:chemistry*
D001713:Biphenyl Compounds; D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen; D011994:Recombinant Proteins; D013256:Steroids