title: Dry eye after laser in situ keratomileusis.
abstract: OBJECTIVE
  To determine whether patients undergoing laser in situ keratomileusis have postoperative dry eye.
  
  
  METHODS
  In this retrospective, interventional case series, 124 eyes of 64 consecutive patients who underwent laser in situ keratomileusis were examined for a dry eye symptom, Schirmer test with anesthesia, tear clearance rate, tear break-up time, vital staining for ocular surface, corneal sensitivity, and blink rate. All values were compared before and after surgery (1 month, 3 months, 6 months, and 1 year) and values of P <.05 were considered statistically significant.
  
  
  RESULTS
  Subjective score for dryness was increased after laser in situ keratomileusis. Tear function index (Schirmer value/tear clearance rate) and break-up time were decreased until 1 month (tear function index) and 3 months (break-up time) after laser in situ keratomileusis but recovered to preoperative levels thereafter. Fluorescein and rose bengal scores were unchanged at all follow-up points except for improvement of the rose bengal score at 6 months. Corneal sensitivity was decreased at 1 month and 3 months, and returned to the preoperative level at 6 months after laser in situ keratomileusis. Blink rate was decreased at 3 months, 6 months, and 1 year after laser in situ keratomileusis.
  
  
  CONCLUSIONS
  Patients undergoing laser in situ keratomileusis develop dry eye with compromised tear function for at least 1 month after surgery. Use of artificial tears in the early postoperative period may help to prevent unwanted symptoms and ocular surface damage.
authors: Minamiaoyama Eye Clinic, Tokyo, Japan. ikuko@tka.att.ne.jp
authors: I
authors: I
authors: Toda
authors: N
authors: N
authors: Asano-Kato
authors: Y
authors: Y
authors: Komai-Hori
authors: K
authors: K
authors: Tsubota
mesh_terms: D000328:Adult; D001767:Blinking; D003315:Cornea / Q000502:physiology; D015352:Dry Eye Syndromes / Q000209:etiology* / Q000378:metabolism; D005260:Female; D006801:Humans; D020731:Keratomileusis, Laser In Situ / Q000009:adverse effects*; D008297:Male; D012677:Sensation / Q000502:physiology; D013666:Tears / Q000378:metabolism