Narcolepsy and other non-SAS hypersomnia in sleep breathing disorders clinic.
Four of the 708 snorers (0.56%), referred to our sleep breathing disorders clinic for the past 2 years were diagnosed as having narcolepsy-cataplexy. Detecting HLA DRB1*1501/DQB1*0602 positive was informative for differentiating genuine narcolepsy from non-sleep apnea syndrome (non-SAS) hypersomnia in our clinic. A non-SAS obese boy, diagnosed as having essential hypersomnia syndrome, was found to be HLA DRB1*1502/DQB1*0601 positive. His hypocretin concentration was 206 pg/mL in the cerebrospinal fluid.
Banno
K
K
The Third Department of Internal Medicine, Sleep Disorders Center, Aichi Medical University School of Medicine, Aichi, Japan. katsu@aichi-med-u.ac.jp
Shiomi
T
T
Sasanabe
R
R
Hasegawa
R
R
Otake
K
K
Yamakawa
H
H
Kobayashi
T
T
Horiba
K
K
Nishino
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000554:Ambulatory Care Facilities; D002352:Carrier Proteins / Q000134:cerebrospinal fluid; D006970:Disorders of Excessive Somnolence / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology; D005260:Female; D006683:HLA-DQ Antigens / Q000276:immunology; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000276:immunology; D059811:HLA-DRB1 Chains; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000150:complications* / Q000453:epidemiology* / Q000276:immunology; D009479:Neuropeptides / Q000134:cerebrospinal fluid; D000068797:Orexins; D012891:Sleep Apnea Syndromes / Q000150:complications*
D002352:Carrier Proteins; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins