Large cell neuroendocrine cervical carcinoma: a report of two cases and review of the literature.
BACKGROUND
Large cell neuroendocrine cervical carcinoma is a rare malignancy. These tumors appear to mimic the aggressive behavior of small cell neuroendocrine tumors. Metastasis and recurrent disease are common. Due to the low incidence of these tumors, optimal therapy has not been delineated.


METHODS
Two patients presented with large cell neuroendocrine cervical carcinoma, stage IB1 and IIA, at our institution from 1997 to 1999. We describe the clinical course for these two patients and review the relevant literature for the management of large cell cervical carcinoma.


CONCLUSIONS
Unlike squamous cell carcinoma, early-stage large cell neuroendocrine tumors of the cervix are aggressive. Disease recurrences are frequent and distant metastasis is common. Multimodal therapy should be considered at the time of initial diagnosis.
Krivak
T C
TC
Division of Gynecologic Oncology, Department of Pathology, Walter Reed Army Medical Center, 6900 Georgia Avenue, Washington, DC, 20307, USA. TomKrivak@aol.com
McBroom
J W
JW
Sundborg
M J
MJ
Crothers
B
B
Parker
M F
MF
D000328:Adult; D018287:Carcinoma, Large Cell / Q000473:pathology* / Q000601:surgery; D018278:Carcinoma, Neuroendocrine / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery