How proteins move lipids and lipids move proteins.
Cells determine the bilayer characteristics of different membranes by tightly controlling their lipid composition. Local changes in the physical properties of bilayers, in turn, allow membrane deformation, and facilitate vesicle budding and fusion. Moreover, specific lipids at specific locations recruit cytosolic proteins involved in structural functions or signal transduction. We describe here how the distribution of lipids is directed by proteins, and, conversely, how lipids influence the distribution and function of proteins.
Sprong
H
H
Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam.
van der Sluijs
P
P
van Meer
G
G
D001692:Biological Transport; D002462:Cell Membrane / Q000502:physiology*; D008051:Lipid Bilayers; D008563:Membrane Lipids / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D015394:Molecular Structure; D021381:Protein Transport; D011506:Proteins / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology
D008051:Lipid Bilayers; D008563:Membrane Lipids; D011506:Proteins