Ethambutol analogues as potential antimycobacterial agents.
A range of new ethambutol analogues was synthesised and their inhibitory potencies were probed with Mycobacterium smegmatis. Interestingly, apparently even minor deviation from the structure of the parent compound resulted in reduced antimycobacterial activity.
Häusler
H
H
Glycogroup, Institut für Organische Chemie der Technischen Universität Graz, Stremayrgasse 16, A-8010, Graz, Austria.
Kawakami
R P
RP
Mlaker
E
E
Severn
W B
WB
Stütz
A E
AE
D000995:Antitubercular Agents / Q000737:chemistry / Q000494:pharmacology*; D004977:Ethambutol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D020102:Mycobacterium smegmatis / Q000187:drug effects*
D000995:Antitubercular Agents; D004977:Ethambutol