New type II manumycins produced by Streptomyces nodosus ssp. asukaensis and their biosynthesis.
Five new type II manumycins, containing the hydroxyquinol mC7N unit, asukamycins A-II, B-II, C-II, D-II, E-II, were discovered in cultures of Streptomyces nodosus ssp. asukaensis. The biosynthetic origin of the type II manumycins from the type I compounds, containing an epoxyquinol mC7N unit, was deduced from the time course of production and proven by preparing [7'-13C]asukamycin A and demonstrating its incorporation into asukamycin A-II.
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Department of Chemistry, University of Washington, Seattle 98195-1700, USA.
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D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011090:Polyenes / Q000138:chemical synthesis / Q000737:chemistry; D053284:Polyunsaturated Alkamides; D013302:Streptomyces / Q000201:enzymology / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D011090:Polyenes; D053284:Polyunsaturated Alkamides; C013404:asukamycin; C054474:manumycin