title: The effects of supplementation with 19-nor-4-androstene-3,17-dione and 19-nor-4-androstene-3,17-diol on body composition and athletic performance in previously weight-trained male athletes.
abstract: The purpose of this study was to determine the effects of 8 weeks of norsteroid supplementation on body composition and athletic performance in previously weight-trained males. Subjects were weight and percent body fat matched and randomly assigned to receive either 100 mg of 19-nor-4-androstene-3,17-dione (N-dione) and 56 mg of 19-nor-4-androstene-3,17-diol (N-diol; 156 mg total norsteroid per day), or a placebo (a multivitamin). Each subject participated in resistance training 4 days/week for the duration of the study. Body composition was assessed via dual-energy X-ray absorptiometry. Circumference measures were taken of a relaxed and flexed arm (maximum circumference of the arm), waist (level of umbilicus), and thigh (15 cm proximal to the patella). Strength was determined with a one-repetition maximum bench press, while force and power were determined with a dumbbell bench press (60% body weight) on a Stratec Galileo force platform. Profile of mood states scores were evaluated for vigor and fatigue. There were no significant changes in any of the parameters measured. In conclusion, low-dose supplementation with N-dione and N-diol does not appear to alter body composition, exercise performance, or mood states.
authors: University of Nebraska, Human Performance Laboratory, Kearney, NE 68849, USA.
authors: D
authors: D
authors: Van Gammeren
authors: D
authors: D
authors: Falk
authors: J
authors: J
authors: Antonio
mesh_terms: D000328:Adult; D000734:Androstenediols / Q000008:administration & dosage / Q000494:pharmacology*; D000735:Androstenedione / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D001823:Body Composition / Q000187:drug effects*; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D010806:Physical Education and Training; D014891:Weight Lifting
chemical_list: C438965:19-nor-4-androstene-3,17-diol; D000734:Androstenediols; D000735:Androstenedione; C002828:19-norandrostenedione