title: Spectroscopic imaging of bone marrow composition in vertebral bodies.
abstract: The proton spectroscopic imaging technique that uses read gradient during acquisition was used for the measurement of the proton spectra in the lumbar and thoracic part of the spine of a patient with breast cancer without known skeletal metastases. The bone marrow fat/water ratios were evaluated in the same location before and after chemotherapy treatment. The results were corrected for relaxation effects. The fat/water ratios showed a significant increase as a consequence of the bone marrow degradation process due to chemotherapy. The proposed spectroscopic imaging technique offers rapid acquisition of proton spectra from large volumes of the vertebral bodies.
authors: Department of Oncology, Radiology and Clinical Immunology, Uppsala University Hospital, Uppsala, Sweden. jan.weis@mta.uas.lul.se
authors: J
authors: J
authors: Weis
authors: I
authors: I
authors: Ciray
authors: A
authors: A
authors: Ericsson
authors: H
authors: H
authors: Lindman
authors: G
authors: G
authors: Aström
authors: H
authors: H
authors: Ahlström
authors: A
authors: A
authors: Hemmingsson
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011522:Protons; D013053:Spectrophotometry / Q000379:methods*; D013131:Spine / Q000473:pathology*; D014867:Water
chemical_list: D011522:Protons; D014867:Water