Odorants elicit evoked potentials in the human amygdala.
Electroencephalographical (EEG) recording studies have shown that odorants produce olfactory evoked potentials (OEPs) on the scalp surface. However, EEGs can only provide limited information about the intracerebral sources from where the OEPs are generated. By contrast, intracerebral EEG recordings enable direct examination of the electrophysiological activity from a given cerebral area. In the present study, neural activity was recorded from the amygdala of seven epileptic patients undergoing intracerebral EEG recordings prior to surgical treatment for relief of intractable seizures. Two olfactory tests were used: a passive-stimulation test consisting of the successive presentation of 12 common odorants and a suprathreshold detection test including both odorant and non-odorant stimulations. Recordings from the amygdala revealed that all odorant stimulations induced large and reproducible OEPs, whereas the non-odorant stimulations did not. It was also found that repetition of the same odorant stimulation led to a decrease in the latency of the first OEP component. This modulation, which corresponds to a faster olfactory processing, strongly suggests that the amygdala is involved in early olfactory attentional processes. In conclusion, it appears that the human amygdala discriminates the incoming information from the nasal airflow as being odorant or not and, additionally, that its speed of processing is sensitive to recent experience with an odor.
Hudry
J
J
Laboratoire de Neurosciences et Systèmes Sensoriels, Université Claude-Bernard, F-69366 Lyon Unité de Neurologie Fonctionnelle et d'Epileptologie, Hôpital Neurologique Pierre Wertheimer, F-69003 Lyon, France.
Ryvlin
P
P
Royet
J P
JP
Mauguière
F
F
D000293:Adolescent; D000328:Adult; D000679:Amygdala / Q000502:physiology*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000601:surgery; D005071:Evoked Potentials / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009812:Odorants; D012684:Sensory Thresholds / Q000502:physiology; D013268:Stimulation, Chemical