Effect of clindamycin therapy on phagocytic and oxidative activity profiles of spleen mononuclear cells in Babesia rodhaini-infected mice.
Spleen weight, the number of spleen mononuclear cells, and their phagocytic activity in groups of Babesia rodhaini-infected mice treated with diminazene diaceturate and clindamycin increased significantly in the early stage of treatment, and then decreased in the final stage of treatment to approximately the pre-infection level. The number of F4/80-positive macrophages and their oxidative activity per mean whole-spleen weight also increased significantly during the course of treatment in comparison with the untreated group. The increases in the clindamycin-treated group were more prominent than those in the group treated with diminazene diaceturate, suggesting the effectiveness of clindamycin therapy for murine babesiosis.
Wijaya
A
A
Department of Veterinary Science, Faculty of Agriculture, Miyazaki University, Japan.
Wulansari
R
R
Ano
H
H
Makimura
S
S
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D001403:Babesia; D001404:Babesiosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D002981:Clindamycin / Q000627:therapeutic use*; D004133:Diminazene / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D010100:Oxygen / Q000378:metabolism; D018512:Parasitemia / Q000188:drug therapy / Q000662:veterinary; D010587:Phagocytosis / Q000187:drug effects; D012376:Rodent Diseases / Q000188:drug therapy* / Q000469:parasitology; D013154:Spleen / Q000166:cytology / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000981:Antiprotozoal Agents; D002981:Clindamycin; C003915:diminazene aceturate; D010100:Oxygen; D004133:Diminazene