Alkyne cross metathesis reactions of extended scope.
[figure: see text] A catalyst formed in situ from Mo[N(t-Bu)(Ar)]3 1 (Ar = 3,5-dimethylphenyl) and CH2Cl2 in toluene effects cross metathesis reactions of functionalized alkynes that are beyond reach of more traditional promotors. An application to the synthesis of prostaglandin E2 (PGE2) 19 and the acetylated PGE derivative 18b shows the compatibility of this method with sensitive substrates.
Fürstner
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Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim/Ruhr, Germany. fuerstner@mpi-muelheim.mpg.de
Mathes
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C