title: Antioxidative glucosides from the fruits of Ligustrum lucidum.
abstract: The ethanol extract of the fruits of Ligustrum lucidum was shown to have inhibitory effects on the hemolysis of red blood cells induced by 2,2'-azo-bis-(2-amidinopropane) dihydrochloride. Bioassay-guided analysis led to the isolation of ten secoiridoid glucosides. Two of them were new, lucidumosides C and D. Their structures were elucidated by spectroscopic methods. The other eight compounds were identified as oleoside dimethyl ester, ligustroside, oleuropein, nuezhenide, isonuezhenide, neonuezhenide, lucidumoside A and lucidumoside B. Five compounds, oleoside dimethyl ester, oleuropein, neonuezhenide, lucidumoside B and lucidumoside C, exhibited strong antioxidant effect against hemolysis of red blood cells induced by free radicals.
authors: Department of Biology, Institute of Chinese Medicine, The Chinese University of Hong Kong.
authors: Z D
authors: ZD
authors: He
authors: But PPH
authors: T W
authors: TW
authors: Chan
authors: H
authors: H
authors: Dong
authors: H X
authors: HX
authors: Xu
authors: C P
authors: CP
authors: Lau
authors: H D
authors: HD
authors: Sun
mesh_terms: D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification*; D002236:Carbohydrate Conformation; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification*; D019684:Magnoliopsida / Q000737:chemistry*; D013057:Spectrum Analysis
chemical_list: D000975:Antioxidants; D005960:Glucosides