title: Familial nasal NK/T-cell lymphoma and pesticide use.
abstract: Familial occurrence of nasal NK/T-cell lymphoma (NNKTCL) in pesticide users is presented. The proband (71 years old, male) and son (39 years old) were both diagnosed with NNKTCL within interval of 26 months. Laboratory data showed slight anemia, with no abnormal cells in peripheral blood. They and their wives were farmers and used large amounts of pesticides (fungicides and insecticides) in the hothouse. NNKTCL did not develop in the wives. Proband's father was diagnosed with malignant lymphoma of the neck and died of the disease. Genetic analyses of the peripheral blood leukocytes and tumor tissues did not show p53 and k-ras gene mutations and microsatellite instability. Metaphase cells from peripheral blood leukocytes bore specific marker chromosomes (father, 44XY,-14,-17,-18,-22,+2mar; son, 46XY,-17,+1mar). Environmental exposures to pesticides in conjunction with familial or genetic factors might increase the risk for NNKTCL.
authors: Department of Otorhinolaryngology, University of the Ryukyus Faculty of Medicine, Nishihara, Okinawa, Japan.
authors: S
authors: S
authors: Kojya
authors: J
authors: J
authors: Matsumura
authors: L
authors: L
authors: Ting
authors: T
authors: T
authors: Hongyo
authors: J
authors: J
authors: Inazawa
authors: M
authors: M
authors: Kirihata
authors: K
authors: K
authors: Aozasa
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D020732:Cytogenetic Analysis; D004781:Environmental Exposure / Q000009:adverse effects; D005192:Family Health; D020022:Genetic Predisposition to Disease; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D016399:Lymphoma, T-Cell / Q000139:chemically induced* / Q000209:etiology / Q000235:genetics; D008297:Male; D009669:Nose Neoplasms / Q000139:chemically induced* / Q000209:etiology / Q000235:genetics; D010375:Pedigree; D010575:Pesticides / Q000009:adverse effects*
chemical_list: D010575:Pesticides