The casein kinase I family: roles in morphogenesis.
Wnt signals play important roles in development and oncogenesis and are transduced through at least two pathways: a canonical beta-catenin-dependent and a beta-catenin-independent cascade. Casein kinase I (CKI) is required in both invertebrates and vertebrates to transduce canonical Wnt signals. However, its role in the beta-catenin-independent pathway was unknown. During vertebrate embryogenesis, the beta-catenin-independent cascade is thought to control cell movements and has been postulated to be analogous to the Drosophila planar cell polarity pathway, which signals through the JNK cascade. Here, we report that blocking CKI function inhibits embryonic morphogenesis and activates JNK in cell lines. These studies suggest that CKI might also act in the beta-catenin-independent pathway and indicate a role for CKI during convergence extension in early vertebrate development.
McKay
R M
RM
Center for Developmental Biology, University of Texas Southwestern Medical Center, Dallas, TX 75390-9133, USA.
Peters
J M
JM
Graff
J M
JM
D016475:3T3 Cells; D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D047388:Casein Kinases; D002454:Cell Differentiation; D003598:Cytoskeletal Proteins / Q000378:metabolism; D000072261:Dishevelled Proteins; D004330:Drosophila; D005799:Genes, Dominant; D051379:Mice; D005810:Multigene Family; D010750:Phosphoproteins / Q000378:metabolism; D020033:Protein Isoforms; D011494:Protein Kinases / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D017434:Protein Structure, Tertiary; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D020133:Reverse Transcriptase Polymerase Chain Reaction; D015398:Signal Transduction; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051176:beta Catenin
D048868:Adaptor Proteins, Signal Transducing; C495267:CTNNB1 protein, mouse; D003598:Cytoskeletal Proteins; D000072261:Dishevelled Proteins; D010750:Phosphoproteins; D020033:Protein Isoforms; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D051176:beta Catenin; D011494:Protein Kinases; D047388:Casein Kinases