title: Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.
abstract: Based upon synthetic and biochemical results, a novel and potent tacrine analogue and heterobivalent analogues of tacrine, were designed. The role played by the amino groups of homo- and heterobivalent ligands in the interaction with the peripheral and catalytic sites of AChE and BuChE were investigated. The syntheses of these materials together with the results of AChE/BuChE inhibition assays are detailed.
authors: Dipartimento Farmaco Chimico Tecnologico, Università degli Studi di Siena, via Aldo Moro, 53100, Siena, Italy. svaini@unisi.it
authors: L
authors: L
authors: Savini
authors: G
authors: G
authors: Campiani
authors: A
authors: A
authors: Gaeta
authors: C
authors: C
authors: Pellerano
authors: C
authors: C
authors: Fattorusso
authors: L
authors: L
authors: Chiasserini
authors: J M
authors: JM
authors: Fedorko
authors: A
authors: A
authors: Saxena
mesh_terms: D000110:Acetylcholinesterase / Q000737:chemistry / Q000378:metabolism*; D002091:Butyrylcholinesterase / Q000737:chemistry / Q000378:metabolism*; D020134:Catalytic Domain; D008024:Ligands; D013619:Tacrine / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008024:Ligands; D013619:Tacrine; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase