Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea.
Bioassay-guided investigation of the twigs of Ochanostachys amentacea using LNCaP (hormone-dependent human prostate cancer) cells as a monitor led to the isolation of three alkynes, the known (S)-17-hydroxy-9,11,13,15-octadecatetraynoic acid (minquartynoic acid, 1) and two novel analogues, (S)-17,18-dihydroxy-9,11,13,15-octadecatetraynoic acid (2) and (S)-17-hydroxy-15E-octadecen-9,11,13-triynoic acid (3). Compounds 1-3 were tested against a panel of human tumor cell lines and found to be significantly cytotoxic.
Ito
A
A
Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
Cui
B
B
Chávez
D
D
Chai
H B
HB
Shin
Y G
YG
Kawanishi
K
K
Kardono
L B
LB
Riswan
S
S
Farnsworth
N R
NR
Cordell
G A
GA
Pezzuto
J M
JM
Kinghorn
A D
AD
D000480:Alkynes; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D053279:Polyynes; D014407:Tumor Cells, Cultured
D000480:Alkynes; D003603:Cytotoxins; D005231:Fatty Acids, Unsaturated; C417933:minquartynoic acid; D053279:Polyynes