[The drug hypersensitivity syndrome or DRESS syndrome to phenobarbital].
Drug Rash with Eosinophilia and Systemic Symptoms (DRESS syndrome) or the drug hypersensitivity syndrome is a delayed and serious skin disease. It is manifest by a severe skin reaction associated with a severe visceral attack (adenopathy, hepatitis, nephritis, interstitial pneumopathy...) and haematological anomalies (raised hypereosinophilia...). The severe visceral attack is the main cause of death, which is estimated at around 10%. The principal drugs responsible are the aromatic anti-convulsants, sulphamides and minocycline. A large number of cases have been described with phenytoin, more rarely with carbamazepine and phenobarbitone.
Lachgar
T
T
Touil
Y
Y
D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D004487:Edema / Q000139:chemically induced / Q000276:immunology; D004802:Eosinophilia / Q000139:chemically induced* / Q000276:immunology; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000139:chemically induced* / Q000276:immunology; D010634:Phenobarbital / Q000009:adverse effects*; D013577:Syndrome
D000927:Anticonvulsants; D010634:Phenobarbital