title: Current status of injectable agents for female stress urinary incontinence.
abstract: The purpose of this review is to summarize the results of reports of injectable agents for the treatment of female urinary stress incontinence. Five agents were reviewed: collagen, Teflon, autologous fat, silicone microparticles, and silicone microballoons. Collagen was the most frequently reported agent and yielded short-term cure and improved rates of 74%-100%. This deteriorated to approximately 57% with longer term follow-up. Teflon has similarly lower longer term than short-term success rates, at 33%-76%. The reported local complications and the potential for particle migration have resulted in its lack of widespread acceptance. Autologous fat has yielded the lowest success rate. Longer term success in a small number of silicone microparticle articles was similar to the other injectables at approximately 60%. Early success with silicone microballoons was 70%. The technique is generally free of major morbidity. The indication for injectables is intrinsic sphincter deficiency but hypermobility is not a contraindication. Long-term durability, cost effectiveness, and some safety issues still have to be addressed by further clinical trials.
authors: Division of Urology, University of Toronto, Sunnybrook and Women's Health Sciences Centre, 2075 Bayview Avenue, Toronto, Ontario M4N 3M5, Canada.
authors: S
authors: S
authors: Herschorn
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation; D001672:Biocompatible Materials / Q000008:administration & dosage*; D003094:Collagen / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007267:Injections / Q000379:methods; D018579:Patient Selection; D011138:Polytetrafluoroethylene / Q000008:administration & dosage; D019736:Prostheses and Implants; D012826:Silicone Elastomers / Q000008:administration & dosage; D014550:Urinary Incontinence, Stress / Q000628:therapy*
chemical_list: D001672:Biocompatible Materials; C075314:GAX-collagen; D012826:Silicone Elastomers; D011138:Polytetrafluoroethylene; D003094:Collagen