Disseminated nocardiosis in a patient with X-linked chronic granulomatous disease and human immunodeficiency virus infection.
We report the first case of HIV infection in a patient with underlying X-linked chronic granulomatous disease (CGD) who presented with hepatopulmonary nocardiosis. Despite the coexistence of CGD and HIV, the response to therapy was normal, and no unusual sequelae were noted. The patient's high virus burden was successfully repressed with antiretroviral therapy, suggesting that the nicotinamide adenine dinucleotide phosphate oxidase system is not essential for active viral replication or response to antiretroviral agents.
Sereti
I
I
Laboratory of Immunoregulation, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-1886, USA.
Holland
S M
SM
D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D000328:Adult; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000000981:diagnostic imaging / Q000382:microbiology / Q000503:physiopathology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D008297:Male; D009615:Nocardia / Q000187:drug effects / Q000302:isolation & purification; D009617:Nocardia Infections / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000382:microbiology / Q000503:physiopathology; D013902:Radiography, Thoracic; D014057:Tomography, X-Ray Computed; D016896:Treatment Outcome; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*; D014960:X Chromosome
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D015662:Trimethoprim, Sulfamethoxazole Drug Combination