First direct deprotonation-electrophile trapping of simple epoxides: synthesis of alpha,beta-epoxysilanes from terminal epoxides.
[figure: see text] The presence of a suitable diamine ligand is the key to achieving ring lithlation-substitution of epoxides without the need for activating substituents on the epoxide and constitutes a new synthetic entry to trans-alpha,beta-epoxysilanes.
Hodgson
D M
DM
Dyson Perrins Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford OX1 3QY, U.K. david.hodgson@chem.ox.ac.uk
Norsikian
S L
SL