Synthesis of novel sialylmimetics as biological probes.
Glycomimetics are increasingly being recognised as powerful tools in the search for novel compounds that possess useful biological properties. This paper describes our preliminary efforts towards the development of novel mimetics of sialic acid thioglycosides. These sialylmimetics are readily prepared and have been shown, in some instances, to have biological properties similar to sialic acid thioglycosides.
Bradley
S J
SJ
Department of Medicinal Chemistry, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria, 3052, Australia.
Fazli
A
A
Kiefel
M J
MJ
von Itzstein
M
M
D000818:Animals; D006801:Humans; D018716:Molecular Mimicry; D015335:Molecular Probes; D012795:Sialoglycoproteins / Q000138:chemical synthesis* / Q000737:chemistry; D013865:Thioglycosides / Q000138:chemical synthesis / Q000737:chemistry
D015335:Molecular Probes; D012795:Sialoglycoproteins; D013865:Thioglycosides