title: Fat-specific satiety in humans for fat high in linoleic acid vs fat high in oleic acid.
abstract: OBJECTIVE
  To investigate the effect of 2 week use of oils high in linoleic (LA), gamma-linolenic (GLA) and oleic acid (OA) on energy intake (EI), macronutrient composition, parameters of appetite and taste perception.
  
  
  METHODS
  A randomized placebo-controlled 2-week treatment, followed by a test day.
  
  
  METHODS
  Two-week treatments, daily life; test day, laboratory restaurant.
  
  
  METHODS
  Eight overweight men and eight overweight women (body mass index 27.4+/-1.5 kg/m(2)).
  
  
  METHODS
  Three 2 week treatments, in which subjects replaced their habitual fat products by three different oils (relatively) high in LA (66.8%), GLA (20.2%) or OA (79.6%, placebo). The wash-out periods were 2 weeks. Before each intervention period, taste perception and sensory specific satiety was tested.
  
  
  RESULTS
  Even though energy intake was higher during dinner, subjects ate relatively less fat with LA (45.0+/-9.4 E%, P<0.05) than with OA (48.3+/-8.3 E%). Subjects did not distinguish the oils with the different fatty acids from each other. There was no relation between satiety or fat-specific satiety and taste characterization without as well as with sucrose. Although no differences were seen for the AUC of the appetite profile, aet 15:00 h subjects were less satiated with LA (46.1+/-6.2 mm, P<0.05) or GLA (45.1+/-5.8 mm, P<0.01) than after treatment OA (62.5+/-4.8 mm). 24 h EI on the test day was 7.6--8.0 MJ and did not differ between treatments.
  
  
  CONCLUSIONS
  Fat-specific satiety during dinner with LA vs OA was shown after a 2-week treatment of each oil, but no change in general satiety. Fat specific satiety was not related to taste perception or characterization of the oils.
authors: Department of Human Biology, Maastricht University, Maastricht, The Netherlands. M.Kamphuis@hb.unimaas.nl
authors: M M
authors: MM
authors: Kamphuis
authors: M S
authors: MS
authors: Westerterp-Plantenga
authors: W H
authors: WH
authors: Saris
mesh_terms: D000328:Adult; D001066:Appetite / Q000502:physiology*; D004435:Eating; D002149:Energy Intake; D005260:Female; D006801:Humans; D019787:Linoleic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D019301:Oleic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D012527:Satiation; D016037:Single-Blind Method; D013649:Taste; D017965:gamma-Linolenic Acid / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D019301:Oleic Acid; D017965:gamma-Linolenic Acid; D019787:Linoleic Acid