Human blood platelet gC1qR/p33.
Platelets are involved in the development of many types of vascular lesions. In addition to their role in primary hemostasis, they participate in inflammatory processes that may contribute to the development of thrombosis, atherosclerosis and vasculitis. In this regard, we have been interested in platelet interactions with the complement subcomponent C1q. C1q has been shown to modulate platelet interactions with collagen and immune complexes, and has been identified at sites of vascular injury and inflammation, as well as in atherosclerotic lesions. Platelets express a variety of C1q binding sites, including gC1qR/p33 (gC1qR), a multifunctional, multicompartment cellular protein. Here we focus on the structure and function of platelet gC1qR and its emerging role in modulating platelet function at sites of vascular injury and inflammation.
Peerschke
E I
EI
Department of Pathology, Weill Medical College of Cornell University, New York, USA. epeersch@med.cornell.edu
Ghebrehiwet
B
B
D001422:Bacterial Adhesion; D019921:Biotinylation; D001779:Blood Coagulation Factors / Q000378:metabolism; D001792:Blood Platelets / Q000276:immunology*; D002352:Carrier Proteins; D015922:Complement C1q / Q000378:metabolism; D006801:Humans; D018960:Hyaluronan Receptors; D007705:Kinins / Q000378:metabolism; D008024:Ligands; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D010974:Platelet Aggregation; D011485:Protein Binding; D011951:Receptors, Complement / Q000097:blood / Q000737:chemistry / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D013203:Staphylococcal Infections / Q000276:immunology; D013205:Staphylococcal Protein A / Q000378:metabolism; D013211:Staphylococcus aureus / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology; D014774:Virulence
D001779:Blood Coagulation Factors; C087299:C1QBP protein, human; D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D007705:Kinins; D008024:Ligands; D008562:Membrane Glycoproteins; D024101:Mitochondrial Proteins; D011951:Receptors, Complement; D011993:Recombinant Fusion Proteins; D013205:Staphylococcal Protein A; C032402:complement 1q receptor; D015922:Complement C1q