Concentration of soluble adhesion molecules (sVCAM-1, sICAM-1 and sL-selectin) in the cerebrospinal fluid and serum of patients with multiple sclerosis and systemic lupus erythematosus with central nervous involvement.
OBJECTIVE
The aim of the present study was to investigate the role of soluble adhesion molecules in the pathogenesis of multiple sclerosis (MS) and systemic lupus erythematosus (SLE) with demyelinating syndrome.


METHODS
Paired cerebrospinal fluid (CSF) and serum samples were analysed by an ELISA method to determine the concentrations of sVCAM-1, sICAM-1 and sL-selectin. Intrathecal syntheses of the adhesion molecules were calculated.


RESULTS
Elevated serum and CSF concentrations of sVCAM-1 were present in all patient groups. Intrathecal synthesis of sVCAM-1 was present in the relapsing-remitting and secondary progressive forms of MS. Intrathecal synthesis of sICAM-1 was observed in all clinical forms of MS. MS patients with progressive forms of the disease and SLE patients were characterised by intrathecal synthesis of sL-selectin.


CONCLUSIONS
The data presented suggest that (1) blood-brain barrier damage can be assumed both in systemic disease and organ-specific disease (sVCAM-1), (2) clinical forms of MS differ from each other in respect to concentrations of adhesion molecules and (3) similar immunological events in the central nervous system of SLE patients with demyelinating syndrome and progressive forms of MS can be assumed (sL-selectin).
Baraczka
K
K
Department of Neuroimmunology, National Institute of Rheumatology and Physiotherapy, Semmelweis University Budapest, Budapest, Hungary. apintasci@mol.hu
Nékám
K
K
Pozsonyi
T
T
Jakab
L
L
Szongoth
M
M
Seszták
M
M
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology / Q000503:physiopathology*; D001799:Blood Sedimentation; D001812:Blood-Brain Barrier; D001921:Brain / Q000473:pathology; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D015331:Cohort Studies; D003711:Demyelinating Diseases; D018450:Disease Progression; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D019041:L-Selectin / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000134:cerebrospinal fluid / Q000145:classification / Q000276:immunology / Q000503:physiopathology*; D011446:Prospective Studies; D012995:Solubility; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid
D002556:Cerebrospinal Fluid Proteins; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D019041:L-Selectin