title: Novel polymorphisms in human macrophage inflammatory protein-1 alpha (MIP-1alpha) gene.
abstract: Human macrophage inflammatory protein-1 alpha (MIP-1alpha) is a chemotactic cytokine, which binds to macrophages, T cells, and B cells affecting their activation. We found novel polymorphisms at four sites within MIP-1alpha gene in Japanese population: C to T in exon 2; A to G in intron 2; C to G and A to G in exon 3. They occurred on the same allele. Although MIP-1alpha effectively suppresses the replication of HIV-1 in vitro, we observed no statistically significant difference in the allele frequency of this polymorphism between HIV-1-infected and uninfected individuals in Japanese population. Since an increased transcription level of MIP-1alpha has been reported to be associated with inflammatory diseases such as atopic dermatitis, we also investigated the frequency of these polymorphisms among patients with atopic dermatitis, HIV-1-infected individuals (with a normal IgE level), and healthy donors. A small increase in ratio of homozygotes to other genotypes was observed in patients with atopic dermatitis (P = 0.04).
authors: Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
authors: X
authors: X
authors: Xin
authors: K
authors: K
authors: Nakamura
authors: H
authors: H
authors: Liu
authors: E E
authors: EE
authors: Nakayama
authors: M
authors: M
authors: Goto
authors: Y
authors: Y
authors: Nagai
authors: Y
authors: Y
authors: Kitamura
authors: T
authors: T
authors: Shioda
authors: A
authors: A
authors: Iwamoto
mesh_terms: D000483:Alleles; D044466:Asian People / Q000235:genetics*; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D003876:Dermatitis, Atopic / Q000235:genetics*; D005787:Gene Frequency; D015658:HIV Infections / Q000235:genetics; D015497:HIV-1; D006801:Humans; D007564:Japan; D019402:Macrophage Inflammatory Proteins / Q000235:genetics*
chemical_list: D054405:Chemokine CCL3; D054407:Chemokine CCL4; D019402:Macrophage Inflammatory Proteins