[The influence of cortisol on several links of metabolism in myeloid cells and leukocytes].
The influence of cortisol on the activity of enzymes that catalyze several stages of energy metabolism, proteolysis and antioxidant system in the bone marrow myeloid cells, neutrophils and lymphocytes of 7-10-day aged piglets was investigated. It was established that durable hormone administration (40 mg per kg body weight every 12 hours during 3 days) caused the decrease in the initial stages of glycolysis and pentose phosphate way intensities, as well as inhibition of cytochrome-c oxidase and antioxidant enzymes activities in the cells of mentioned populations. Such effects of cortisol on the intracellular metabolism may represent the important link in the mechanisms of glucocorticoid inhibition of myeloid cells and circulating leucocytes functional activities.
Antoniak
H L
HL
Institute of Agriculture and Animal Biology, Lviv.
Snityns'kyĭ
V V
VV
Iskra
R Ia
RIa
Babych
N O
NO
D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D001854:Bone Marrow Cells / Q000378:metabolism*; D002384:Catalysis; D004734:Energy Metabolism / Q000502:physiology*; D004789:Enzyme Activation; D004798:Enzymes / Q000378:metabolism; D006854:Hydrocortisone / Q000378:metabolism*; D007962:Leukocytes / Q000378:metabolism*; D010084:Oxidation-Reduction; D013552:Swine
D000975:Antioxidants; D004798:Enzymes; D006854:Hydrocortisone