Rational design of a new series of pronucleotide.
A new pronucleotide series is described involving a two-step degradation process mediated by, respectively, carboxylesterase and phosphoramidase. Taking AZT as nucleosidyl moiety, it is shown that most of the compounds inhibit HIV replication in TK(-) cell line, which proves 5'-AZTMP delivery.
Beltran
T
T
UMR 5625 CNRS-UM II, Université Montpellier II, cc 008, place E. Bataillon, 34095 Cedex 05, Montpellier, France.
Egron
D
D
Pompon
A
A
Lefebvre
I
I
Périgaud
C
C
Gosselin
G
G
Aubertin
A
A
Imbach
J
J
D019380:Anti-HIV Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D015195:Drug Design; D006678:HIV / Q000502:physiology; D009711:Nucleotides / Q000737:chemistry* / Q000494:pharmacology; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D019380:Anti-HIV Agents; D009711:Nucleotides; D011355:Prodrugs