title: Hepatopulmonary syndrome in candidates for liver transplantation.
abstract: BACKGROUND
  Hepatopulmonary syndrome (HPS) has been defined as a clinical triad, including chronic liver disease, gas exchange defects (increased alveolar-arterial PO2 difference irrespective of the presence of arterial hypoxemia), and widespread intrapulmonary vascular dilatations. We determined the incidence and the clinical and pulmonary functional characteristics of HPS in candidates for orthotopic liver transplantation (OLT) and tested their predicted accuracy.
  
  
  METHODS
  We studied 80 patients with cirrhosis prospectively, and carried out contrast-enhanced (CE) echocardiography and lung function tests, including ventilation-perfusion (V(A)/Q) distributions.
  
  
  RESULTS
  Fourteen patients had HPS (incidence, 17.5%). Patients with HPS (49 +/- 12 (+/-SD) years) had more cutaneous spiders, finger clubbing and dyspnea (P < 0.05 each) and a lower diffusing capacity (DLCO, 56 +/- 18% predicted; P < 0.001) than non-HPS patients (n = 66). Mild to moderate V(A)/Q inequalities and increased intrapulmonary shunt were predominant in HPS patients, but oxygen diffusion impairment was observed in those with hypoxemia (n = 8) only. The DLCO showed a considerable area under the receiver operating characteristic curve (0.89).
  
  
  CONCLUSIONS
  HPS in cirrhotic patient candidates for OLT shows a high incidence and these patients present with distinctive clinical and functional features compared with non-HPS individuals. The presence of a low DLCO may be of help for the diagnosis of HPS.
authors: Servei de Anestesiologia i Reanimació, Institut d'Investigacions Biomèdiques August Pi i Sunyer, Hospital Clinic, Universitat de Barcelona, Spain.
authors: G P
authors: GP
authors: Martínez
authors: J A
authors: JA
authors: Barberà
authors: J
authors: J
authors: Visa
authors: A
authors: A
authors: Rimola
authors: J C
authors: JC
authors: Paré
authors: J
authors: J
authors: Roca
authors: M
authors: M
authors: Navasa
authors: J
authors: J
authors: Rodés
authors: R
authors: R
authors: Rodriguez-Roisin
mesh_terms: D000328:Adult; D004417:Dyspnea / Q000150:complications; D005260:Female; D005385:Fingers / Q000002:abnormalities; D020065:Hepatopulmonary Syndrome / Q000150:complications / Q000453:epidemiology / Q000503:physiopathology* / Q000601:surgery*; D006801:Humans; D015994:Incidence; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011653:Pulmonary Diffusing Capacity; D014692:Ventilation-Perfusion Ratio