Triple ring closing metathesis reaction: synthesis of adjacent cyclic ethers.
[reaction: see text] Adjacent tris(cyclic ethers) and enol ethers have been synthesized in good yields for the first time via a triple olefin metathesis reaction using Grubbs' catalyst RuCl(2)(=C(H)Ph)(PCy(3))(2) (Cy = cyclohexyl), and the 1,3-dimesitylimidazol-2-ylidene ruthenium benzylidene catalyst RuCl(2)(=C(H)Ph)(PCy(3))(IMes) ((IMes) = 1,3-bis(2,4,6-trimethylphenyl)imidazol-2-ylidene). The latter proved to be the most efficient catalyst in these transformations.
Heck
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MP
CEA-CE Saclay, Service des Molécules Marquées, Bât 547, Département de Biologie Cellulaire et Moléculaire, F-91191 Gif sur Yvette cedex, France. heck@dsvidf.cea.fr
Baylon
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C
Nolan
S P
SP
Mioskowski
C
C