Oligomeric antigen receptors: a new view on signaling for the selection of lymphocytes.
Antigen receptors on lymphocytes utilize different signaling modes to control the positive and negative selection of lymphocytes. In addition, these receptors have to detect the amount and affinity of the antigen and set delicate threshold values for the activation of lymphocytes. It is suggested that the antigen receptors on B and T-cells form oligomeric complexes, inside of which, signals can be processed and amplified in a manner that might explain the different signaling outputs of these receptors.
Reth
M
M
Dept of Molecular Immunology, Biology III, University of Freiburg and Max-Planck-Institute for Immunobiology, Stübeweg 51, 79108 Freiburg, Germany. reth@immunbio.mpg.de
D000818:Animals; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D018448:Models, Immunological; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell