Anti-Müllerian hormone and its receptors.
Anti-Müllerian hormone (AMH), a member of the transforming growth factor-beta family, is an important factor of male sex differentiation. It is produced by Sertoli cells from the time of fetal sex differentiation to puberty. AMH is also produced by granulosa cells from the time of birth to the end of ovarian activity. As other members of the transforming growth factor-beta family, AMH signals through two related but distinct receptors, both serine/threonine kinases with a single transmembrane domain, called type II and type I. The type II receptor has been cloned in 1994 and is expressed solely in AMH target organs. Engagement of the type I receptor BMPR-IB and downstream effector Smad1 by AMH has recently been demonstrated, however, its role in AMH biological actions remains to be proven.
Josso
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Unité de Recherches sur l'Endocrinologie du Développement (INSERM), Ecole Normale Supérieure, Département de Biologie, 1 rue Maurice-Arnoux, 92120 Montrouge, France. josso@wotan.ens.fr
di Clemente
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Gouédard
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D000818:Animals; D054304:Anti-Mullerian Hormone; D052005:Bone Morphogenetic Protein Receptors, Type I; D005260:Female; D005786:Gene Expression Regulation / Q000235:genetics / Q000502:physiology*; D006023:Glycoproteins; D006107:Granulosa Cells / Q000166:cytology / Q000378:metabolism; D006131:Growth Inhibitors / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D006801:Humans; D008297:Male; D009095:Mullerian Ducts / Q000002:abnormalities / Q000187:drug effects; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D018000:Receptors, Peptide / Q000378:metabolism*; D018125:Receptors, Transforming Growth Factor beta; D012708:Sertoli Cells / Q000166:cytology / Q000378:metabolism; D012733:Sex Differentiation / Q000187:drug effects / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013735:Testicular Hormones / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*; D016212:Transforming Growth Factor beta / Q000096:biosynthesis / Q000494:pharmacology / Q000502:physiology*
D006023:Glycoproteins; D006131:Growth Inhibitors; D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; D013735:Testicular Hormones; D016212:Transforming Growth Factor beta; C084621:anti-Mullerian hormone receptor; D054304:Anti-Mullerian Hormone; D017346:Protein Serine-Threonine Kinases; C498214:BMPR1B protein, human; D052005:Bone Morphogenetic Protein Receptors, Type I