The sibling species Drosophila melanogaster and Drosophila simulans differ in the expression profile of glutathione S-transferases.
Two major forms of glutathione S-transferase are known in Drosophila melanogaster: GST D and GST 2. In the present paper we report the existence of a third major form of glutathione S-transferase in Drosophila simulans. Induction with phenobarbital revealed a different regulation of GST between these species. Despite the fact that these two species are closely related, there was a difference in the expression profile of the enzyme implicated in the detoxification system, suggesting variations in capacity to suit their environment.
Le Goff
G
G
INRA, UMR 1112 ROSE, Equipe Resistance aux Xenobiotiques et Ecotoxicologie, BP 2078-123 Boulevard Francis Meilland, 06606 Cedex, Antibes, France. legoff@antibes.inra.fr
Bride
J
J
Cuany
A
A
Bergé
J
J
Amichot
M
M
D000818:Animals; D015153:Blotting, Western; D004330:Drosophila / Q000145:classification* / Q000201:enzymology*; D004331:Drosophila melanogaster / Q000145:classification* / Q000201:enzymology*; D005982:Glutathione Transferase / Q000096:biosynthesis* / Q000302:isolation & purification; D010634:Phenobarbital / Q000494:pharmacology; D020033:Protein Isoforms; D013045:Species Specificity
D020033:Protein Isoforms; D005982:Glutathione Transferase; D010634:Phenobarbital