title: Relationship between circulating high density lipoprotein concentrations and interleukin-6 release during abdominal operations.
abstract: OBJECTIVE
  To investigate whether circulating high density lipoprotein (HDL) concentrations influence inflammatory cytokine release during abdominal operations.
  
  
  METHODS
  University Hospital, Japan.
  
  
  METHODS
  30 patients who underwent curative operations for gastric cancer.
  
  
  METHODS
  Serum HDL and cytokine concentrations were measured preoperatively, and portal and systemic blood samples were taken for the analysis of cytokine and endotoxin concentrations during operations.
  
  
  RESULTS
  Portal blood interleukin-6 (IL-6) values of patients with low serum HDL concentrations (n = 6) (< 0.9 mmol/L) were significantly (p < 0.01) higher than those in patients with normal or high HDL concentrations (n = 24) (> or = 0.9 mmol/L) (80.63 (74.62) pg/ml (mean (SD)) compared with 10.25 (9.61) pg/ml.). Moreover, an inverse correlation (r = -0.43, p < 0.05) was found between portal blood IL-6 concentrations and circulating HDL concentrations.
  
  
  CONCLUSIONS
  We suggest that serum HDL concentrations influence IL-6 release in response to abdominal operations. Circulating HDL particles may reduce endotoxin-induced IL-6 release in humans.
authors: Department of Surgery, The Jikei University School of Medicine, Tokyo, Japan.
authors: T
authors: T
authors: Fujita
authors: A
authors: A
authors: Hara
authors: Y
authors: Y
authors: Yamazaki
mesh_terms: D000368:Aged; D008076:Cholesterol, HDL / Q000097:blood*; D005260:Female; D005743:Gastrectomy; D006801:Humans; D015850:Interleukin-6 / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood / Q000601:surgery; D013312:Stress, Physiological / Q000097:blood*
chemical_list: D008076:Cholesterol, HDL; D015850:Interleukin-6