title: Distribution of amino acid residues and residue-residue contacts in molecular chaperones.
abstract: The amino acid distribution and residue-residue contacts in molecular chaperones are different when compared to normal globular proteins. The study of molecular chaperones reveals a different surrounding environment to exist for the residues Cys, Trp, and His which may play an important role in determining the chaperone structures. Unlike globular proteins, it has been observed that a one-to-one correspondence between the amino acid distribution in a sequence and the structures of molecular chaperones. The preference of amino acid residues surrounding all 20 types of residues in secondary structures and their accessible surface areas have been analysed.
authors: Department of Crystallography and Biophysics, University of Madras, Chennai, Tamil Nadu, India.
authors: T S
authors: TS
authors: Kumarevel
authors: M M
authors: MM
authors: Gromiha
authors: M N
authors: MN
authors: Ponnuswamy
mesh_terms: D000596:Amino Acids / Q000032:analysis* / Q000378:metabolism; D003545:Cysteine / Q000737:chemistry; D006639:Histidine / Q000737:chemistry; D018832:Molecular Chaperones / Q000737:chemistry* / Q000378:metabolism; D017510:Protein Folding; D017433:Protein Structure, Secondary; D014364:Tryptophan / Q000737:chemistry
chemical_list: D000596:Amino Acids; D018832:Molecular Chaperones; D006639:Histidine; D014364:Tryptophan; D003545:Cysteine