March 2000: A 16 year old female with a cerebellar mass.
The March COM: A 16 year old female presented with headaches and cerebellar dysfunction. MR images showed a mass lesion of the right cerebellar hemisphere with mass effect on the medulla. The mass exhibited a striated pattern of alternating isointense and hypointense zones on T1-weighted images that did not contrast enhance. The lesion was hyperintense on T2-weighted images, and also showed a striated appearance. A suboccipital craniotomy and resection of the lesion was performed. Microscopically, the specimen consisted of widened folia and a disorganized cerebellar architectonic pattern in which the internal granular cell layer was occupied by a population of large dysmorphic nerve cell bodies. Patient's diagnosed with Lhermitte-Duclos disease must be adequately evaluated for Cowden's syndrome.
Cummings
T J
TJ
Department of Pathology, Duke University Medical Center, Durham, North Carolina, USA.
Ebert
R H
RH
Provenzale
J
J
McLendon
R E
RE
D000293:Adolescent; D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor / Q000032:analysis; D002528:Cerebellar Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003399:Craniotomy; D005260:Female; D005684:Gait; D005729:Ganglioneuroma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006261:Headache / Q000209:etiology; D006801:Humans; D016900:Neurofilament Proteins / Q000032:analysis; D009474:Neurons / Q000473:pathology; D009687:Nuclear Proteins / Q000032:analysis
D034961:Antigens, Nuclear; D014408:Biomarkers, Tumor; D016900:Neurofilament Proteins; D009687:Nuclear Proteins