title: [Extraction of di-2-ethylhexyl phthalate from a cardiopulmonary bypass circuit].
abstract: We measured levels of di-2-ethylhexyl phthalate (DEHP) in a priming solution of a cardiopulmonary bypass circuit. The circuit consisted of a venous reservoir, an oxygenator, and polyvinyl chloride (PVC) tubes. Eight circuits were used in this study. In 4 circuits a heparin-coating PVC tube was used and, in the others, a non-coating PVC tube. After they were primed with 1,500 ml of saline, the saline was circulated for 30 minutes at a rate of 6 l/min at 42 degrees C. Another four samples were collected directly from the saline in a polyethylene container as a control. Then the concentrations of DEHP in them were determined by means of gas chromatography. No detectable DEHP was found in controls. But, a small amount was detected in the saline from the circuits (2.75 +/- 4.27 ppb, and 3.75 +/- 4.99 ppb, respectively). DEHP was considered to be leached from the circuit to the priming solution because the tubes were made of PVC containing DEHP as a plasticizer. We suppose the DEHP concentration is probably at a safe level. However, the data on the endocrinologically toxic level of blood DEHP are insufficient. Therefore, the use of plastic in a circuit may require closer scrutiny to determine whether DEHP leached from PVC contributes to exposure to xenoestrogens.
authors: Department of Cardiovascular Surgery, Shakaihoken Chukyo Hospital, Nagoya, Japan.
authors: H
authors: H
authors: Sakurai
authors: M
authors: M
authors: Maeda
authors: K
authors: K
authors: Miyahara
authors: M
authors: M
authors: Nakayama
authors: H
authors: H
authors: Murayama
authors: H
authors: H
authors: Hasegawa
authors: M
authors: M
authors: Hayakawa
authors: T
authors: T
authors: Sugiura
authors: K
authors: K
authors: Kamikura
mesh_terms: D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D004051:Diethylhexyl Phthalate / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans
chemical_list: D004051:Diethylhexyl Phthalate