title: Phylogenetic reconstruction of intrapatient evolution of human immunodeficiency virus type 1: predominance of drift and purifying selection.
abstract: The intra-host evolution of 73 human immunodeficiency virus type 1 quasispecies was analysed by split decomposition analysis. Non-synonymous and synonymous nucleotide substitutions were counted along the shortest path connecting all sequences and compared with the numbers expected under the assumption of a random model of mutation. For the majority of substitutions, drift and negative selection seemed to prevail.
authors: Abteilung Virologie, Universität des Saarlandes, Institut für Medizinische Mikrobiologie und Hygiene, Klinikum Homburg, Haus 47, D-66421 Homburg, Germany1.
authors: Laurens
authors: L
authors: Kils-Hütten
authors: Unité de Rétrovirologie Moléculaire, Institut Pasteur, F-75724 Paris cedex 15, France2.
authors: Rémi
authors: R
authors: Cheynier
authors: Unité de Rétrovirologie Moléculaire, Institut Pasteur, F-75724 Paris cedex 15, France2.
authors: Simon
authors: S
authors: Wain-Hobson
authors: Abteilung Virologie, Universität des Saarlandes, Institut für Medizinische Mikrobiologie und Hygiene, Klinikum Homburg, Haus 47, D-66421 Homburg, Germany1.
authors: Andreas
authors: A
authors: Meyerhans
mesh_terms: D005075:Biological Evolution; D005787:Gene Frequency; D015752:Genes, env; D015750:Genes, gag; D015754:Genes, nef; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D013997:Time Factors