Neuropathology of paediatric chronic intestinal pseudo-obstruction and related animal models.
Chronic intestinal pseudo-obstruction (CIP) in paediatric patients is due to heterogeneous aetiologies that include primary disorders of the enteric nervous system. These conditions are poorly delineated by contemporary diagnostic approaches, in part because the complex nature of the enteric nervous system may shelter significant physiological defects behind subtle or quantitative anatomical changes. Until recently, relatively few experimental animal models existed for paediatric CIP. However, the availability of rodent models, particularly novel mutants created in the last few years by genetic manipulations, has brought unprecedented opportunities to investigate molecular, cellular, physiological, and histological details of enteric neuropathology. Information gleaned from studies of these animals is likely to change diagnostic and therapeutic approaches to paediatric CIP and related conditions.
Kapur
R P
RP
Department of Pathology, University of Washington, Seattle, Washington 98195, USA. kapur@u.washington.edu
D000818:Animals; D000880:Anthraquinones / Q000009:adverse effects; D000962:Antimalarials; D001342:Autonomic Nervous System Diseases / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D002400:Cathartics / Q000009:adverse effects; D002908:Chronic Disease; D003092:Colitis / Q000473:pathology / Q000503:physiopathology; D017615:Enteric Nervous System / Q000473:pathology / Q000503:physiopathology*; D005725:Ganglia, Autonomic / Q000473:pathology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007418:Intestinal Pseudo-Obstruction / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D016464:Lysosomal Storage Diseases / Q000473:pathology / Q000503:physiopathology; D051379:Mice; D023421:Models, Animal; D011796:Quinacrine; D051381:Rats; D014748:Vinca Alkaloids / Q000009:adverse effects
D000880:Anthraquinones; D000962:Antimalarials; D002400:Cathartics; D014748:Vinca Alkaloids; D011796:Quinacrine