A circadian system model with feedback of cross-correlation between sleep-wake rhythm and oscillator.
Recent findings suggest that social entrainment factors work on an oscillator other than the temperature and melatonin rhythms. This indicates that there is a feedback loop affected on oscillators. In the present study, a circadian system model, including mutually coupled two oscillators and sleep-wake rhythm, is constructed, where cross-correlation between a sleep-wake rhythm and an oscillator is set to modify the coupling from one oscillator to the other. Based on the model simulation, a mechanism underlying delayed sleep phase syndrome is elucidated by the reduction in the cross-correlation resulting from dissociation between the delayed sleep phase and the oscillator.
Nakao
M
M
Graduate School of Information Sciences, Tohoku University, Sendai, Japan. nakao@ecei.tohoku.ac.jp
Yamamoto
K
K
Nakamura
K
K
Katayama
N
N
Yamamoto
M
M
D001831:Body Temperature / Q000502:physiology; D002940:Circadian Rhythm / Q000502:physiology*; D005246:Feedback / Q000502:physiology*; D006801:Humans; D008027:Light; D008550:Melatonin / Q000502:physiology; D008954:Models, Biological; D014851:Wakefulness / Q000502:physiology*
D008550:Melatonin