Mitotic kinases as regulators of cell division and its checkpoints.
Mitosis and cytokinesis are undoubtedly the most spectacular parts of the cell cycle. Errors in the choreography of these processes can lead to aneuploidy or genetic instability, fostering cell death or disease. Here, I give an overview of the many mitotic kinases that regulate cell division and the fidelity of chromosome transmission.
Nigg
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Max-Planck-Institute for Biochemistry, Department of Cell Biology, Am Klopferspitz 18a, D-82152 Martinsried, Germany. nigg@biochem.mpg.de
D000705:Anaphase / Q000502:physiology; D000818:Animals; D016203:CDC2 Protein Kinase / Q000502:physiology; D002455:Cell Division / Q000502:physiology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000502:physiology; D016195:G2 Phase / Q000502:physiology; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D009369:Neoplasms / Q000201:enzymology / Q000235:genetics / Q000473:pathology; D011494:Protein Kinases / Q000502:physiology*; D016196:S Phase / Q000502:physiology; D015398:Signal Transduction; D008941:Spindle Apparatus / Q000502:physiology
D011494:Protein Kinases; D016203:CDC2 Protein Kinase