title: Basal forebrain microinjections of L-3,3',5-triiodothyronine modify sleep in hypothyroid rats.
abstract: Male rats were injected bilaterally with various doses of L-3,3',5-triiodothyronine (T3) into basal forebrain areas. The electroencephalogram (EEG), electromyogram (EMG) and brain temperature (Tbr) were then measured in 8-h studies. In the medial preoptic area (MPA), a 4 microg dose of T3 caused significant elevations in REM sleep as compared to control injections. In the median preoptic nucleus (MnPO), both 2 and 4 microg doses of T3 significantly inhibited non-REM sleep. Injections to the diagonal band of Broca did not alter EEG-defined sleep. Influences on Tbr were not significant for any of the treatments. Since these effects of T3 were demonstrated after acute injections, the data are consistent with possible non-genomic actions of thyroid hormones in adult brain.
authors: Department of Biology, Rutgers the State University of New Jersey, Camden, New Jersey 08102-1411, USA.
authors: S Q
authors: SQ
authors: Zhang
authors: J V
authors: JV
authors: Martin
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000502:physiology; D004569:Electroencephalography; D004576:Electromyography; D007037:Hypothyroidism / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008845:Microinjections; D011301:Preoptic Area; D016548:Prosencephalon; D051381:Rats; D012893:Sleep Wake Disorders / Q000188:drug therapy* / Q000209:etiology; D012895:Sleep, REM / Q000187:drug effects*; D014284:Triiodothyronine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014284:Triiodothyronine