title: IGF-I, IGFBP-2 and -3 but not GH concentrations are different in normal and poor growing piglets.
abstract: In this study we investigated the somatotropic axis in piglets with evident growth delay. Female Suffolk crossbred piglets (30 days old; N = 12) were divided into normal weight (10 +/- 0.9 kg) and poor growing subjects (7 +/- 0.5 kg) and bled for growth hormone (GH), Insulin-like growth factor-I (IGF-I), Insulin-like growth factor binding protein 2 and 3 (IGFBP-2 and -3) determination. Basal and induced-GH levels were not different in the groups. Plasma IGF-I concentrations were significantly different (p < 0.001): 101.8 +/- 9.8 ng x mL(-1) (normal weight group) and 39.5 +/- 4.0 ng x mL(-1) (poor growing group). IGFBP-2 and -3 concentrations were significantly (p < 0.001) lower in poor growing than in normal piglets. Piglet weight was positively correlated (r = 0.98, p < 0.001) with IGF-I and IGFBP-2 or -3 concentrations. Our data indicate that growth rate was not correlated to basal or secretagogue-induced GH secretion.
authors: Istituto di Fisiologia Veterinaria, Università di Parma, Italy.
authors: R
authors: R
authors: Saleri
authors: M
authors: M
authors: Baratta
authors: G L
authors: GL
authors: Mainardi
authors: R
authors: R
authors: Renaville
authors: A
authors: A
authors: Giustina
authors: F
authors: F
authors: Quintavalla
authors: C
authors: C
authors: Tamanini
mesh_terms: D000818:Animals; D001835:Body Weight; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000503:physiopathology / Q000662:veterinary; D013006:Growth Hormone / Q000032:analysis / Q000097:blood*; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000032:analysis / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000032:analysis / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D013552:Swine / Q000097:blood / Q000254:growth & development*; D013553:Swine Diseases / Q000097:blood / Q000503:physiopathology
chemical_list: D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone