Histone H1 diversity: bridging regulatory signals to linker histone function.
Genes encoding linker histone variants have evolved to link their expression to signals controlling the proliferative capacities of cells, i.e. cycling and growth-arrested cells express distinct and specific H1 subtypes. In metazoan, these variants show a tripartite structure, with considerably divergent sequences in their amino and carboxyl terminus domains. The aim of this review is to show how specific regulatory signals control the expression of an individual H1 and to discuss the functional significance of the two variables associated with a linker histone: its primary sequence and the timing of its expression.
Khochbin
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Laboratoire de Biologie Moléculaire et Cellulaire de la Différenciation - INSERM U309, Equipe chromatine et expression des gènes, Institut Albert Bonniot, Faculté de Médecine, Domaine de la Merci, 38706 La Tronche Cedex, France. khochbin@ujf-grenoble.fr
D000595:Amino Acid Sequence; D000818:Animals; D014644:Genetic Variation; D006657:Histones / Q000235:genetics* / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D006657:Histones