MR proton spectroscopy in patients with CNS involvement in Bourneville's disease.
BACKGROUND
Despite much previous research, the origin of intracranial lesions in tuberous sclerosis is still unknown. We present MR and proton magnetic resonance (1H-MRS) studies of two patients with tuberous sclerosis.


METHODS
The study material consisted of MR and 1H-MRS examinations from 2 patients (4-5 years old) with tuberous sclerosis. MR images (FSE, FAST, FLAIR) were obtained with a 1.5 T unit. Localized 1H-MRS studies (PRESS 35, TE 35 ms, TR 1500 ms, NEX 192) on cortical (n=3) and subependymal (n=1) lesions were also performed.


RESULTS
Decreased N-acatyloaspartate/creatine (NAA/Cr) and increased myoinositol/creatine (mI/Cr) ratios were observed in the spectra obtained from the subcortical and subependymal tubers.


CONCLUSIONS
Our observations confirm the hypothesis that disturbances of migration, adhesion and differentiation of germ neuronal cells may underlay the pathogenesis of tuberous sclerosis.
Tarasów
E
E
Department of Radiology, Medical University Hospital, Bialystok, Poland.
Kubas
B
B
Walecki
J
J
D002493:Central Nervous System Diseases / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D014402:Tuberous Sclerosis / Q000473:pathology*