title: Regio-reactive resin: a platform for orthogonal loading using the polymer backbone and cross-linker.
abstract: A new support for solid-phase combinatorial organic synthesis has been developed, which we term a regio-reactive resin (R(3)-resin). The resin is based on a unique hydroxyl-functionalized cross-linker readily synthesized in two steps starting from 4-hydroxybenzaldehyde. The cross-linker's ease of synthesis and high purity enables the preparation of gel-type resins with regio-reactive orthogonal loading sites. The resin's swelling properties were investigated, and its potential utility was demonstrated via orthogonal reactivity of the pendant and cross-linker sites.
authors: Department of Chemistry and The Skaggs Institute for Chemical Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA.
authors: T J
authors: TJ
authors: Dickerson
authors: N N
authors: NN
authors: Reed
authors: K D
authors: KD
authors: Janda
mesh_terms: D000042:Absorption; D000438:Alcohols / Q000737:chemistry; D003432:Cross-Linking Reagents / Q000737:chemistry; D011137:Polystyrenes / Q000737:chemistry; D012116:Resins, Plant / Q000138:chemical synthesis* / Q000737:chemistry; D014867:Water
chemical_list: D000438:Alcohols; D003432:Cross-Linking Reagents; D011137:Polystyrenes; D012116:Resins, Plant; D014867:Water