title: Synthesis of thalprzewalskiinone, a revision of structure.
abstract: A direct comparison of the spectral data for synthetic 2-methyl-6,7-dimethoxy-3'-methoxy-4'-hydroxyoxobenzylisoquinoline iodide (1) and its positional isomer 2-methyl-6,7-dimethoxy-3'-hydroxy-4'-methoxyoxobenzylisoquinoline iodide (2) with the data obtained for the oxobenzylisoquinoline alkaloid thalprzewalskiinone revealed that the original structural assignment of the alkaloid as 1 was in error. These results mandate the revision of structure of thalprzewalskiinone to 2-methyl-6,7-dimethoxy-3'-hydroxy-4'-methoxyoxobenzylisoquinoline iodide (2).
authors: Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
authors: T A
authors: TA
authors: Al-Howiriny
authors: M A
authors: MA
authors: Zemaitis
authors: C Y
authors: CY
authors: Gao
authors: C E
authors: CE
authors: Hadden
authors: G E
authors: GE
authors: Martin
authors: F T
authors: FT
authors: Lin
authors: P L
authors: PL
authors: Schiff
mesh_terms: D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D007202:Indicators and Reagents; D007546:Isoquinolines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004365:Drugs, Chinese Herbal; D007202:Indicators and Reagents; D007546:Isoquinolines; C433624:thalprzewalskiinone