Assessment of radical prostatectomy specimens and diagnostic reporting of pathological findings.
Proper examination of radical prostatectomy (RP) specimens from patients with prostate cancer (PCa) is critical for determining the need for adjuvant treatment and for predicting the outcome. The first step in the examination is represented by the assessment of the specimens. This includes proper fixation in formalin and whole-mount sectioning. The second step is related to the diagnostic reporting of pathological findings. This includes the evaluation of tissue features such as Gleason grade, stage and margin status. These three parameters, together with serum prostate-specific antigen (PSA) determination, are predictive factors whose prognostic role has been demonstrated in several studies.
Montironi
R
R
Institute of Pathological Anatomy, University of Ancona, Umberto I Hospital, I-60020 Torrette, Ancona, Italy. r.montironi@popcsi.unian.it
Lopez-Beltran
A
A
Mazzucchelli
R
R
Scarpelli
M
M
Bollito
E
E
D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008499:Medical Records; D008867:Microtomy / Q000379:methods; D009361:Neoplasm Invasiveness / Q000473:pathology; D009363:Neoplasm Proteins / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy / Q000379:methods; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology* / Q000601:surgery; D012669:Seminal Vesicles / Q000473:pathology; D012720:Severity of Illness Index; D013048:Specimen Handling / Q000379:methods*; D013194:Staining and Labeling; D016707:Tissue Fixation / Q000379:methods
D009363:Neoplasm Proteins; D017430:Prostate-Specific Antigen