title: Management of vocal fold scar with autologous fat implantation: perceptual results.
abstract: Vocal fold scar disrupts the mucosal wave and interferes with glottic closure. Treatment involves a multidisciplinary approach that includes voice therapy, medical management, and sometimes surgery. We reviewed the records of the first eight patients who underwent autologous fat implantation for vocal fold scar. Information on the etiology of scar, physical findings, and prior interventions were collected. Videotapes of videostroboscopic findings and perceptual voice ratings [Grade, Roughness, Breathiness, Asthenia, Strain (GRBAS)] were randomized and analyzed independently by four blinded observers. Etiology of scar included mass excision (7), vocal fold stripping (3), congenital sulcus (2), and hemorrhage (1). Prior surgical procedures performed included thyroplasty (1), autologous fat injection (9), excision of scar (2), and lysis of adhesions (2). Strobovideolaryngoscopy: Statistically significant improvement was found in glottic closure, mucosal wave, and stiffness (P = 0.05). Perceptual ratings (GRBAS): Statistically significant improvement was found in all five parameters, including overall Grade, Roughness, Breathiness, Asthenia, and Strain (P = 0.05). Patients appear to have improved vocal fold function and quality of voice after autologous fat implantation in the vocal fold. Autologous fat implantation is an important adjunctive procedure in the management of vocal fold scar, and a useful addition to the armamentarium of the experienced phonomicrosurgeon.
authors: Department of Otolaryngology-Head and Neck Surgery, Thomas Jefferson University Hospital, Philadelphia, USA.
authors: M C
authors: MC
authors: Neuenschwander
authors: R T
authors: RT
authors: Sataloff
authors: M M
authors: MM
authors: Abaza
authors: M J
authors: MJ
authors: Hawkshaw
authors: D
authors: D
authors: Reiter
authors: J R
authors: JR
authors: Spiegel
mesh_terms: D000273:Adipose Tissue / Q000637:transplantation*; D000328:Adult; D002921:Cicatrix / Q000150:complications* / Q000503:physiopathology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D012189:Retrospective Studies; D014182:Transplantation, Autologous; D014827:Vocal Cords / Q000503:physiopathology*; D014832:Voice Disorders / Q000209:etiology / Q000503:physiopathology / Q000628:therapy