Inflammatory response, growth, and thyroid hormone concentrations are affected by long-term boron supplementation in gilts.
An experiment was conducted to determine the long-term effects of dietary boron (B) on growth performance, immune function, and plasma and serum characteristics in gilts. Fifty weanling gilts were allotted to 10 pens based on weaning weight and litter origin. Pens were randomly assigned to receive one of two dietary treatments. Treatments consisted of a basal diet low in B (control) and the basal diet supplemented with 5 mg B/kg diet as sodium borate. Gilts remained on their respective experimental diets and with their penmates throughout the nursery, growing, and finishing phases. The B concentration of the basal diet was 0.98, 2.1, and 2.2 mg/kg diet during the nursery, growing, and finishing phases, respectively. At the end of each production phase, animals were weighed and feed consumption was determined to assess growth performance variables. In addition, blood samples were obtained from three randomly selected gilts per pen at the completion of each phase. Boron had no affect (P > 0.58) on growth performance during the nursery phase, but gilts receiving supplemental B had increased (P < 0.05) ADG at the end of the finishing phase and over the entire growing-finishing period. Serum concentrations of triiodothyronine (T3) tended (P < 0.07) to be reduced by dietary B at the end of the nursery phase, but serum thyroxine (T4) was not affected (P = 0.46) by B. At the completion of the growing phase, supplemental B decreased (P < 0.05) the concentrations of T3 and T4 in the serum. In addition, serum concentrations of total cholesterol and the activity of alkaline phosphatase were increased (P < 0.05) by dietary B at the end of the growing phase. Serum concentrations of urea N tended (P < 0.09) to be increased by B at the end of the growing phase. Beginning at d 95 of the experimental period, measures of immune function were assessed in randomly selected gilts. Boron decreased (P < 0.05) the inflammatory response to an intradermal injection of phytohemagglutinin. Boron did not affect (P > 0.30) the blastogenic response of isolated lymphocytes to mitogen stimulation or the humoral immune response against a sheep red blood cell suspension. Results indicate that B may affect serum thyroid hormone concentrations, the inflammatory response, and growth in pigs.
Armstrong
T A
TA
Department of Animal Science and Interdepartmental Nutrition Program, North Carolina State University, Raleigh 27695-7621, USA.
Spears
J W
JW
Lloyd
K E
KE
D000469:Alkaline Phosphatase / Q000097:blood; D000822:Animal Husbandry / Q000379:methods; D000818:Animals; D001881:Borates / Q000494:pharmacology; D001895:Boron / Q000008:administration & dosage / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D004032:Diet / Q000662:veterinary*; D019587:Dietary Supplements; D005260:Female; D007249:Inflammation / Q000662:veterinary*; D011897:Random Allocation; D013552:Swine / Q000254:growth & development*; D013553:Swine Diseases / Q000097:blood*; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014886:Weaning
D001881:Borates; D013963:Thyroid Hormones; D014284:Triiodothyronine; C010634:sodium borate; D002784:Cholesterol; D000469:Alkaline Phosphatase; D001895:Boron; D013974:Thyroxine