The pathophysiology of photosensitivity in lupus erythematosus.
The strong association between photosensitivity and lupus erythematosus has led to the suggestion that abnormal photoreactivity participates in the pathogenesis of cutaneous lesions. In this review we discuss the evidence for abnormal cutaneous reactivity to sunlight in lupus and speculate on the cellular, molecular and genetic factors that may underlie this abnormality.
Orteu
C H
CH
Division of Dermatology, Faculty of Medicine, University of British Columbia, and Vancouver Hospital and Health Science Center, Canada.
Sontheimer
R D
RD
Dutz
J P
JP
D006801:Humans; D008178:Lupus Erythematosus, Cutaneous / Q000503:physiopathology*; D010787:Photosensitivity Disorders / Q000503:physiopathology*