Inhibitory effects of echinoisoflavanone and sophoraisoflavanone D in Sophora chrysophylla SEEM on lipid peroxidation of mice brain homogenate by interaction of ferrous ion and hydrogen peroxide, in vitro.
We present the results of an in vitro investigation of the inhibitory effects of echinoisoflavanone and sophoraisoflavanone D isolated from Sophora chrysophylla SEEM on lipid peroxidation of mice brain homogenate by interaction of ferrous ion and hydrogen peroxide, in vitro. They inhibited lipid peroxidation. The order of inhibitory effects of these isoflavanones and mannitol as a hydroxy radical scavenger was echinoisoflavanone > mannitol > sophoraisoflavanone D. The results suggest that some isoflavanones may be of use in cases where oxidative stress is present.
Toda
S
S
Department of Pharmaceutical Science, Kansai College of Oriental Medicine, Sen-nan, Osaka, Japan.
Shirataki
Y
Y
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism; D007529:Isoflavones / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051379:Mice; D029909:Sophora / Q000737:chemistry
D000975:Antioxidants; D007529:Isoflavones; C441782:echinoisoflavanone; C441783:sophoraisoflavanone D; D006861:Hydrogen Peroxide; D007501:Iron