[Biological model of accelerated senescence. II. Age-related changes in the number of developing male germ cells and Sertoli cells in gonads of senescence-accelerated mice].
It was shown that in immature three- to four-week-old mice prone to accelerated senescence (SAMP1 strain), the number of spermatogonia, pachytene spermatocytes, and circular spermatids exceeded that in mice resistant to accelerated senescence (SAMR1 strain) by more than two times. Differences were found in the pattern of age-related changes in the number of meiotic and postmeiotic cells in the sexually mature SAMP1 and SAMR1 mice. In the gonads of SAMP1 and SAMR1 mice, the number of Sertoli cells was unstable.
Gordeeva
O F
OF
Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, ul. Vavilova 26, Moscow, 117808 Russia.
Zakhidov
S T
ST
Marshak
T L
TL
D000375:Aging; D000818:Animals; D001835:Body Weight; D002452:Cell Count; D005854:Germ Cells / Q000166:cytology* / Q000648:ultrastructure; D008297:Male; D008540:Meiosis; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size; D012708:Sertoli Cells / Q000166:cytology*; D013737:Testis / Q000166:cytology* / Q000648:ultrastructure