The effect of revascularisation of an ischaemic lower limb on leukotriene E4 production.
It has previously been shown that leukotriene E4 production is increased both in acute and chronic lower limb ischaemia. The aim of this study was to measure the effect of revascularisation on leuktriene E4 excretion in chronic lower limb ischaemia. Revascularisation did not affect significantly on leukotriene E4 excretion (preop. 34.9+/-7.1 pg/mg creatinine, postop. 24.5+/-4.7 pg/mg creatinine, n=10, P<0.238). We suggest that the enhanced leukotriene E4 production continues after revascularisation which may have a therapeutical implication.
Rossi
P
P
Department of Surgery, Central Hospital of Central Finland, FIN-40600 Jyväskylä, Finland. perttu.rossi@ksshp.fi
Kuukasjärvi
P
P
Salenius
J P
JP
Riutta
A
A
D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007511:Ischemia / Q000378:metabolism* / Q000601:surgery; D007866:Leg / Q000098:blood supply / Q000473:pathology; D017999:Leukotriene E4 / Q000096:biosynthesis* / Q000652:urine; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply; D014656:Vascular Surgical Procedures
D017999:Leukotriene E4