Effect of ACTH on pain sensitivity in rats.
Systemic administration of ACTH to rats with normal hormone production induced a rapid (started 3 min postinjection) and long-term (persisted 30 min) elevation of pain threshold. Complete inhibition of glucocorticoid production shortened the duration of ACTH-induced analgesia to 15 min. The biphasic effect of ACTH on pain sensitivity is probably mediated by short-term glucocorticoid-independent and long-term glucocorticoid-dependent mechanisms.
Bogdanov
A I
AI
Department of Physiology of Endocrine System, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Yarushkina
N I
NI
D000302:Adrenal Cortex / Q000502:physiology; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology*; D000818:Animals; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D008297:Male; D017288:Pain Threshold / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000324:Adrenocorticotropic Hormone