Long-term outcomes of immunosuppressed renal transplant recipients with malignancies.
This study analyzes ten cases of malignancy in a cohort of 183 renal transplant recipients, examining surgical management, postoperative immunosuppressive therapy, and long-term outcome. One of these ten patients, who had malignant lymphoma of the jejunum, died of the neoplasm, but the other nine patients did not show any signs of tumor recurrence after removal. All of these nine patients, except for one who had transplant renal cell carcinoma (RCC), received the same dose of immunosuppressive agents after surgery for the malignant disease. Seven patients were still alive at the time of this report, six of whom had good transplant renal function. The findings of this study indicate that even if immunosuppressive agents predispose to the development of cancer, it is not necessary to reduce their dose after removal of the tumor.
Gunji
Y
Y
Department of Surgery (II), Chiba University School of Medicine, Japan.
Sakamoto
K
K
Kamura
K
K
Yamada
K
K
Kashiwabara
H
H
Shimada
H
H
Hori
S
S
Suzuki
T
T
Ochiai
T
T
D000328:Adult; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology*; D011183:Postoperative Complications / Q000276:immunology*; D012189:Retrospective Studies; D016896:Treatment Outcome
D007166:Immunosuppressive Agents