An approach to the complexity of the brain.
The establishment of ordered neuronal connections is supposed to take place under the control of specific cell adhesion molecules (CAM) which guide neuroblasts and axons to their appropriate destination. The extreme complexity of the nervous system does not provide a favorable medium for the development of deterministic connections. Simon's [112] theorems offer a mean to approach the high level of complexity of the nervous system. The basic tenet is that complex systems are hierarchically organized and decomposable. Such systems can arise by selective trial and error mechanisms. Subsystems in complex systems only interact in an aggregate manner, and no significant information is lost if the detail of aggregate interactions is ignored. A number of nervous activities, which qualify for these requirements, are shown. The following sources of selection are considered: internal and external feedbacks, previous experience, plasticity in simple structures, and the characteristic geometry of dendrites. The role played by CAMs and other membrane-associated molecules is discussed in the sense that they are either inductor molecules that turn on different homeobox genes, or downstream products of genes, or both. These molecules control cellular and tissular differentiation in the developing brain creating sources of selection required for the trial and error process in the organization of the nervous tissue.
Székely
G
G
Department of Anatomy, Medical and Health Science Center, University of Debrecen, Debrecen, Hungary. szekely@chondron.anat.dote.hu
D000818:Animals; D019521:Body Patterning / Q000502:physiology*; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology*; D048429:Cell Size / Q000502:physiology; D002490:Central Nervous System / Q000166:cytology / Q000196:embryology* / Q000378:metabolism; D003712:Dendrites / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D019006:Neural Cell Adhesion Molecules / Q000378:metabolism*; D009434:Neural Pathways / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology
D019006:Neural Cell Adhesion Molecules