[Evaluation of the peripartum effects of 2 analgesics: meperidine and tramadol, used in labor].
The need for analgesia to overcome pain in labour is highly requested by women today. Various ways either non pharmachologic e.g. Emotional sustain, psycho-prophylactic preparation, yoga and hypnosis or pharmachologic such as epidural blockade or parenteral are used. Therefore in our study we evaluated the efficacy and tolerability of the two opioids usually used today in parenteral analgesia to reduce pain during labour: Tramadol and Meperidine. We studied two groups of patients each made up of 20 women in labour, all at term and with a physiologic course of pregnancy. 75 mg i.m. of Meperidine chloryhydrate were somministered in the first group while in the second group 100 mg i.m. of tramadol chloryhydrate were somministered. Various maternal, fetal and neonatal parameters were then monitored demonstrating--A moderate maternal analgesic effect in both drugs (evaluated through the analogic grading of pain). In the group to whom Meperidine was given, sedative effects on the mother were observed associated with respiratory depression in the newborn (the latter evaluated through the Apgar index at 1st and 5th minute of life and pH of the blood obtained at the umbilical cord. The data obtained permitted us to conclude that Tramadol in accordance to the obtained in literature gives an analogous analgesic effect, with better tolerability for the absence of collateral effects on the mother, fetus and newborn.
Fieni
S
S
Cattedra di Ginecologia e Ostetricia, Clinica Ostetrica e Ginecologica, Università degli Studi di Parma.
Angeri
F
F
Kaihura
C T
CT
Ricci
L
L
Bedocchi
L
L
Galanti
B
B
Rossi
T
T
Benassi
G
G
Benassi
L
L
D016362:Analgesia, Obstetrical; D000701:Analgesics, Opioid / Q000627:therapeutic use*; D015148:Cardiotocography / Q000187:drug effects*; D005260:Female; D006801:Humans; D008614:Meperidine / Q000627:therapeutic use*; D011247:Pregnancy; D014147:Tramadol / Q000627:therapeutic use*
D000701:Analgesics, Opioid; D014147:Tramadol; D008614:Meperidine