Reactivation of chronic Chagas' disease following allogeneic bone marrow transplantation and successful pre-emptive therapy with benznidazole.
This report shows the early detection of reactivation of chronic Chagas' disease (CCd) in a 27-year-old man with chronic myelogenous leukemia undergoing allogeneic bone marrow transplantation (ABMT). Pre-emptive therapy with benznidazole during a period of 7 weeks led to a rapid recovery of the patient, who remains free of parasitemia 2 years after the bone marrow transplantation.
Altclas
J
J
Instituto de Criopreservación y Trasplante de médula ósea, IMA, Buenos Aires, Argentina. jaltclas@intramed.net.ar
Sinagra
A
A
Jaimovich
G
G
Salgueira
C
C
Luna
C
C
Requejo
A
A
Milovic
V
V
De Rissio
A
A
Feldman
L
L
Riarte
A
A
D000328:Adult; D000818:Animals; D016026:Bone Marrow Transplantation; D014355:Chagas Disease / Q000175:diagnosis* / Q000188:drug therapy*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008297:Male; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011183:Postoperative Complications; D012008:Recurrence; D014184:Transplantation, Homologous; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000302:isolation & purification
D009593:Nitroimidazoles; D014344:Trypanocidal Agents; C009999:benzonidazole