Salmonella pathogenicity islands encoding type III secretion systems.
Salmonella enterica harbours two Salmonella pathogenicity islands (SPIs) each encoding a type III secretion system for virulence proteins. SPI1 is required for invasion, while systemic infections and intracellular accumulation of Salmonella are dependent on SPI2 function. This review will describe and compare the genetic organisation, evolution, regulation and molecular functions of SPI1 and SPI2.
Hansen-Wester
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I
Lehrstuhl für Bakteriologie, Max von Pettenkofer-Institut, LMU München, Germany.
Hensel
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M
D000818:Animals; D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism*; D004847:Epithelial Cells / Q000382:microbiology; D019143:Evolution, Molecular; D015964:Gene Expression Regulation, Bacterial; D005798:Genes, Bacterial; D006801:Humans; D010586:Phagocytes / Q000382:microbiology; D010641:Phenotype; D012475:Salmonella / Q000235:genetics* / Q000472:pathogenicity*; D012480:Salmonella Infections / Q000382:microbiology; D014774:Virulence / Q000235:genetics
D001426:Bacterial Proteins