title: Synthesis of 3-indolyl-2,5-dihydroxybenzoquinones.
abstract: [figure: see text] 3-Indolylquinones can be efficiently prepared by the acid-catalyzed condensation of Indoles with 2,5-dichiorobenzoquinone, followed by DDQ oxidation. The resulting dichloroquinones are hydrolyzed to the 3-indolyidihydroxybenzoquinones. The 3-indolylquinone substructure is of interest because of its presence in natural products that modulate biological processes through protein-protein interactions, including the asterriquinones.
authors: Department of Chemistry, Levine Science Research Center, Duke University, Box 90317, Durham, North Carolina 27708, USA. pirrung@chem.duke.edu
authors: M C
authors: MC
authors: Pirrung
authors: K
authors: K
authors: Park
authors: Z
authors: Z
authors: Li
mesh_terms: D016227:Benzoquinones / Q000138:chemical synthesis*; D007211:Indoles / Q000138:chemical synthesis*
chemical_list: D016227:Benzoquinones; D007211:Indoles