title: Statistical issues relating to international differences in clinical trials.
authors: Duke Clinical Research Institute, Durham, NC, USA. oshea002@mc.duke.edu
authors: J C
authors: JC
authors: O'Shea
authors: D L
authors: DL
authors: DeMets
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D008790:Metoprolol / Q000627:therapeutic use*; D015337:Multicenter Studies as Topic; D017410:Practice Guidelines as Topic; D010818:Practice Patterns, Physicians' / Q000706:statistics & numerical data; D013223:Statistics as Topic
chemical_list: D000319:Adrenergic beta-Antagonists; D008790:Metoprolol