Human puromycin-sensitive aminopeptidase: cloning of 3' UTR, evidence for a polymorphism at a.a. 140 and refined chromosomal localization to 17q21.
Puromycin-sensitive aminopeptidase is a predominantly cytoplasmatic zinc-dependent exopeptidase. Its physiological function is not known to date. Here we report data on tissue distribution, a polymorphism within the coding region and the complete 3' UTR. The gene (NPEPPS alias PSA) was physically mapped to chromosome 17q21.2-->q21.32 using fluorescence in situ hybridization.
Bauer
W O
WO
Department of Metabolism, Endocrinology and Molecular Medicine, Medizinische Poliklinik, Würzburg, Germany.
Nanda
I
I
Beck
G
G
Schmid
M
M
Jakob
F
F
D020413:3' Untranslated Regions / Q000235:genetics*; D000595:Amino Acid Sequence; D000626:Aminopeptidases / Q000235:genetics*; D001483:Base Sequence; D002871:Chromosome Banding; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D005786:Gene Expression Regulation / Q000187:drug effects; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D020161:Physical Chromosome Mapping; D011110:Polymorphism, Genetic / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D016415:Sequence Alignment; D014807:Vitamin D / Q000494:pharmacology
D020413:3' Untranslated Regions; D018076:DNA, Complementary; D012333:RNA, Messenger; D014807:Vitamin D; D000626:Aminopeptidases; C025579:enkephalin degrading enzyme