Angiogenesis therapy: amidst the hype, the neglected potential for serious side effects.
Epstein
S E
SE
Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington DC , USA.
Kornowski
R
R
Fuchs
S
S
Dvorak
H F
HF
D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism / Q000473:pathology; D001808:Blood Vessels / Q000187:drug effects / Q000254:growth & development / Q000503:physiopathology; D002199:Capillary Permeability / Q000187:drug effects; D002318:Cardiovascular Diseases / Q000628:therapy*; D018932:Chemokine CCL2 / Q000494:pharmacology; D000075202:Contraindications; D003331:Coronary Vessels / Q000187:drug effects; D003930:Diabetic Retinopathy / Q000378:metabolism; D018450:Disease Progression; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D016228:Endothelial Growth Factors / Q000009:adverse effects / Q000494:pharmacology*; D005346:Fibroblast Growth Factors / Q000009:adverse effects / Q000494:pharmacology*; D005822:Genetic Vectors / Q000009:adverse effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D008222:Lymphokines / Q000009:adverse effects / Q000494:pharmacology*; D051379:Mice; D009369:Neoplasms / Q000378:metabolism; D018919:Neovascularization, Physiologic / Q000187:drug effects*; D009928:Organ Specificity / Q000187:drug effects; D011518:Proto-Oncogene Proteins / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D017978:Receptors, Growth Factor / Q000378:metabolism; D040262:Receptors, Vascular Endothelial Growth Factor; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D042442:Vascular Endothelial Growth Factors; D014666:Vasomotor System / Q000187:drug effects
D018932:Chemokine CCL2; D016228:Endothelial Growth Factors; D008222:Lymphokines; D011518:Proto-Oncogene Proteins; D017978:Receptors, Growth Factor; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D005346:Fibroblast Growth Factors; D020794:Receptor Protein-Tyrosine Kinases; D040262:Receptors, Vascular Endothelial Growth Factor; D040281:Vascular Endothelial Growth Factor Receptor-1