The role of ABC transporters in antibiotic-producing organisms: drug secretion and resistance mechanisms.
Knowledge about biosynthetic gene clusters from antibiotic-producing actinomycetes is continuously increasing and the presence of an ABC transporter system is a fairly general phenomenon in most of these clusters. These transporters are involved in the secretion of the antibiotic through the cell membrane and also contribute to self resistance to the produced antibiotic.
Méndez
C
C
Departamento de Biologiá Funcional e Instituto Universitario de Oncología del Principado de Asturias, Universidad de Oviedo, Spain.
Salas
J A
JA
D018528:ATP-Binding Cassette Transporters / Q000502:physiology*; D000191:Actinomycetaceae / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000378:metabolism; D004352:Drug Resistance, Microbial; D008969:Molecular Sequence Data; D010802:Phylogeny; D017386:Sequence Homology, Amino Acid
D018528:ATP-Binding Cassette Transporters; D000900:Anti-Bacterial Agents