Does moderate alcohol intake protect against coronary heart disease?
There is abundant epidemiological and clinical evidence to show that light-to-moderate drinking is associated with a reduced risk of coronary heart disease (CHD), total and ischemic stroke, and total mortality in middle-aged and elderly men and women. The evidence suggests a J- or U-shaped relationship between alcohol and CHD. Alcohol reduces the risk of coronary heart disease both by inhibiting the formation of atheroma and by decreasing the rate of blood coagulation. It appears that for most conditions, other than cardiovascular diseases and cholelithiasis, moderate alcohol consumption has either none or only an intermediate type of risk as compared with the risk of either abstinence or excessive drinking. It is now fully recognized and accepted that drinking alcohol regularly for years is toxic to almost every tissue of the body. However, most people who choose to drink alcohol have little or no problem limiting their consumption to amounts that do not generally cause serious health or social consequences. Moreover, a given dose of alcohol may affect different people differently. It is, therefore, imperative that a critical evaluation, based on the observations made hitherto, be done of both the harmful and the protective effects of alcohol consumption on various organs/systems of the body. This article reviews epidemiological evidence for the protective effects of alcohol on the cardiovascular system and discusses how alcohol might lower the risk of CHD.
Agarwal
D P
DP
Institute of Human Genetics, University of Hamburg, Germany. agarwal@uke.uni-hamburg.de
Srivastava
L M
LM
D000428:Alcohol Drinking; D003327:Coronary Disease / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D018570:Risk Assessment; D012680:Sensitivity and Specificity