Platelet apheresis for digital gangrene due to thrombocytosis in chronic myeloid leukaemia.
Thrombocytosis is a frequent presenting feature of myeloproliferate disorders and is associated with increased incidence of thrombotic and haemorrhage complications. However, these complications are rare in chronic myeloid leukaemia (CML). We describe a case of CML which presented with digital gangrene due to thrombocytosis. Reduction of the platelet count by plateletpheresis lead to rapid symptomatic relief and recovery from the gangrene.
Win
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National Blood Service - South London Centre, UK. Nay.Win@nbs.nhs.uk
Mitchell
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DC
D000328:Adult; D005734:Gangrene / Q000209:etiology / Q000628:therapy*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications* / Q000473:pathology; D008297:Male; D010976:Platelet Count; D010983:Plateletpheresis; D013922:Thrombocytosis / Q000150:complications* / Q000209:etiology; D014034:Toes / Q000473:pathology