title: Haemoglobin Q-Thailand and hereditary spherocytosis in a Chinese family.
abstract: A Chinese family with concurrent hereditary spherocytosis (HS) and haemoglobin (Hb) Q-Thailand is described. The Hb Q-Thailand mutation was found on the remaining alpha1 globin gene on a chromosome 16 containing the (-alpha 4.2) deletion. Active haemolysis in members of this family is segregated with the HS phenotype, and the Hb Q-Thailand in the heterozygous state does not seem to show any modulating effect on HS.
authors: Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong, People's Republic of China.
authors: K F
authors: KF
authors: Leung
authors: W Y
authors: WY
authors: Au
authors: A Y
authors: AY
authors: Chan
authors: L C
authors: LC
authors: Chan
authors: J S
authors: JS
authors: Waye
authors: D H
authors: DH
authors: Chui
authors: S K
authors: SK
authors: Ma
mesh_terms: D000328:Adult; D000745:Anemia, Hemolytic, Congenital / Q000209:etiology / Q000235:genetics; D002681:China; D005192:Family Health; D005260:Female; D005838:Genotype; D006455:Hemoglobins, Abnormal / Q000235:genetics*; D006579:Heterozygote; D006801:Humans; D009679:Nuclear Family; D009996:Osmotic Fragility / Q000235:genetics; D010375:Pedigree; D010641:Phenotype; D013103:Spherocytosis, Hereditary / Q000097:blood / Q000150:complications / Q000235:genetics*
chemical_list: D006455:Hemoglobins, Abnormal; C049214:hemoglobin Q Thailand