The human hedgehog-interacting protein gene: structure and chromosome mapping to 4q31.21-->q31.3.
Hedgehog-interacting protein (Hhip) is a novel regulatory component in the vertebrate hedgehog-signalling pathway. The murine Hhip encodes a type I TM protein that attenuates hedgehog signalling by binding all three mammalian hedgehog proteins. Here we describe the cloning and characterisation of the homologous human hedgehog-interacting protein gene (HHIP). HHIP comprises 13 exons and spans >91kb encoding a protein of 700 aa which shares 94% sequence iden- tity with mouse Hhip. HHIP maps to chromosome 4q31.21--> q31.3. Additionally, we have mapped murine Hhip to chromosome 8.
Bak
M
M
Department of Medical Genetics, Institute of Medical Biochemistry and Genetics, The Panum Institute, University of Copenhagen, Denmark.
Hansen
C
C
Friis Henriksen
K
K
Tommerup
N
N
D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002894:Chromosomes, Human, Pair 4 / Q000235:genetics*; D020451:Contig Mapping; D005091:Exons / Q000235:genetics*; D020224:Expressed Sequence Tags; D020869:Gene Expression Profiling; D006801:Humans; D020407:Internet; D007438:Introns / Q000235:genetics*; D008126:Lod Score; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D020161:Physical Chromosome Mapping; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D021101:Radiation Hybrid Mapping; D017385:Sequence Homology
D002352:Carrier Proteins; C117596:HHIP protein, human; C498447:Hhip protein, mouse; D008562:Membrane Glycoproteins; D012333:RNA, Messenger