Therapeutic implications of inflammation in atherosclerotic cardiovascular disease.
Atherosclerosis represents a spectrum of pathologic lesions with diverse clinical sequelae. In this review, we build upon the paradigm that arteriosclerosis represents an inflammatory disease. By examining mechanisms involved in the response to vascular injury, we can more effectively implement targeted therapy aimed at halting or regressing arteriosclerosis.
Selzman
C H
CH
Department of Surgery, University of Colorado Health Sciences Center, Denver 80262, USA. craig.selzman@uchsc.edu
Miller
S A
SA
Harken
A H
AH
D001161:Arteriosclerosis / Q000276:immunology* / Q000473:pathology; D016207:Cytokines / Q000378:metabolism; D004730:Endothelium, Vascular / Q000276:immunology / Q000473:pathology; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*
D016207:Cytokines; D006133:Growth Substances; D018836:Inflammation Mediators