title: Predictors of positive margins after local excision of ductal carcinoma in situ.
abstract: BACKGROUND
  This study aimed to examine the association between clinicopathologic parameters and positive margins in women with ductal carcinoma in situ (DCIS) treated by breast-conserving surgery (BCS).
  
  
  METHODS
  We retrospectively reviewed the clinical, radiologic, and pathologic data of 100 women who had undergone BCS for DCIS in our center.
  
  
  RESULTS
  Sixty-seven percent of patients presented via breast screening and 55% of all cases were diagnosed preoperatively on fine needle aspiration cytology ([FNAC] ie, C5). Overall, 45% of patients had clear margins after initial local excision. Positive margins showed a nonsignificant trend of association with distribution of microcalcifications (MCC), nonconsultant operating surgeon, inconclusive preoperative FNAC, presence of necrosis, and low specimen weight. There was a highly significant association between low grade DCIS (P = 0.003) and incomplete excision. There was no significant association with age, associated invasive focus, morphology of MCC, or with mode of presentation.
  
  
  CONCLUSIONS
  Positive margins after local excision of DCIS are significantly associated with low nuclear grade, and preoperative determination of nuclear grade by core biopsy may have surgical implications.
authors: Breast Cancer Centre, St. George's Hospital, London, United Kingdom. kefahmokbel@hotmail.com
authors: K
authors: K
authors: Mokbel
authors: C
authors: C
authors: Choy
authors: C
authors: C
authors: Leris
authors: M
authors: M
authors: Akbar
authors: S
authors: S
authors: Vinnicombe
authors: P
authors: P
authors: Kessar
authors: N
authors: N
authors: Perry
authors: C
authors: C
authors: Wells
authors: R
authors: R
authors: Carpenter
mesh_terms: D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery*; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D018270:Carcinoma, Ductal, Breast / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D015412:Mastectomy, Segmental; D008875:Middle Aged; D012189:Retrospective Studies