Cerebellar atrophy in an epileptic child: is it due to phenytoin?
A four and half year old epileptic child on phenytoin therapy since one year presented with signs of cerebellar dysfunction. Serum phenytoin level was high (33 mcg/ml) and computerised tomographic scan of the brain showed severe generalised cerebellar atrophy. The cerebellar signs represented drug over dosage and toxicity and persisted long after omission of phenytoin.
Ahuja
S R
SR
Division of Paediatric Neurology, Department of Paediatrics, LTM Medical College and Hospital, Sion, Mumbai - 400 022, India.
Karande
S
S
Kulkarni
M V
MV
D000927:Anticonvulsants / Q000009:adverse effects* / Q000627:therapeutic use; D001284:Atrophy / Q000139:chemically induced; D002531:Cerebellum / Q000473:pathology*; D002675:Child, Preschool; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects* / Q000627:therapeutic use
D000927:Anticonvulsants; D010672:Phenytoin