Pathogenicity and resistance islands of staphylococci.
Variable genetic elements including plasmids, transposons and prophages are involved in pathogenesis and antibiotic resistance, and are an important component of the staphylococcal genome. This review covers a set of newly described variable chromosomal elements, pathogenicity and resistance islands, carrying superantigen and resistance genes, especially toxic shock and methicillin resistance, respectively.
Novick
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Molecular Pathogenesis Program, Skirball Institute of Biomolecular Medicine, New York University Medical Center, New York, NY 10016, USA. novick@saturn.med.nyu.edu
Schlievert
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Ruzin
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D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001427:Bacterial Toxins; D001483:Base Sequence; D002876:Chromosomes, Bacterial / Q000235:genetics; D004269:DNA, Bacterial / Q000737:chemistry; D004352:Drug Resistance, Microbial / Q000235:genetics; D004768:Enterotoxins / Q000235:genetics / Q000502:physiology; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D006801:Humans; D016106:Methicillin Resistance / Q000235:genetics; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D012772:Shock, Septic / Q000382:microbiology; D013203:Staphylococcal Infections / Q000188:drug therapy / Q000382:microbiology; D013210:Staphylococcus / Q000187:drug effects / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D018089:Superantigens / Q000235:genetics / Q000502:physiology
D000900:Anti-Bacterial Agents; D001427:Bacterial Toxins; D004269:DNA, Bacterial; D004768:Enterotoxins; D018089:Superantigens; C030107:enterotoxin F, Staphylococcal