title: Unusual liver carcinomas with sarcomatous features: analysis of four cases.
abstract: We recently examined the clinicopathological and immunohistochemical features of four cases of primary hepatic carcinoma with sarcomatoid elements. Three of the four patients had associated ordinary hepatocellular carcinoma (HCC) and one had a sarcomatoid carcinoma with no apparent elements of HCC. The presenting symptoms were high fever and hypochondralgia in three patients, and right hypochondralgia without a high fever in one. The preoperative diagnoses were liver abscess in two patients, HCC in one, and cholangioma in one. Preoperative imaging showed necrotic change or abscess formation in the tumors. The sarcomatous elements showed a positive reaction to vimentin in three patients, but the ordinary HCC cells did not. Macroscopically, the tumors appeared as a single nodule with pericapsular growth. The prognoses of these patients were poor due to the early development of intrahepatic or distal metastases. We conclude that symptoms such as a high fever or hypochondralgia are characteristics of these tumors and that they may be histogenetically derived from a dedifferentiation of HCC, although no elements of HCC were found in one of our cases.
authors: Department of Surgery, Kurume University School of Medicine, Japan.
authors: N
authors: N
authors: Eriguchi
authors: S
authors: S
authors: Aoyagi
authors: K
authors: K
authors: Okuda
authors: M
authors: M
authors: Hara
authors: S
authors: S
authors: Fukuda
authors: T
authors: T
authors: Tamae
authors: M
authors: M
authors: Ohdo
authors: N
authors: N
authors: Kanazawa
authors: M
authors: M
authors: Kawabata
authors: T
authors: T
authors: Kodama
authors: K
authors: K
authors: Nishimura
authors: S
authors: S
authors: Hamada
mesh_terms: D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology* / Q000556:secondary; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008113:Liver Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged