Autoimmunity against the ryanodine receptor in myasthenia gravis.
Some myasthenia gravis (MG) patients have antibodies against skeletal muscle antigens in addition to the acetylcholine receptor (AChR). A major antigen for these antibodies is the Ca2+ release channel of the sarcoplasmic reticulum the ryanodine receptor (RyR). These antibodies are found mainly in MG patients with a thymoma MG and correlate with severe MG symptoms. The antibodies recognize a region near the N-terminus on the RyR, which seems to be of importance for RyR regulation. The antibodies cause allosteric inhibition of RyR function in vitro, inhibiting Ca2+ release from sarcoplasmic reticulum.
Skeie
G O
GO
Department of Neurology, University of Bergen, Bergen, Norway.
Lunde
P K
PK
Sejersted
O M
OM
Mygland
A
A
Aarli
J A
JA
Gilhus
N E
NE
D000818:Animals; D015551:Autoimmunity; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D066298:In Vitro Techniques; D009157:Myasthenia Gravis / Q000150:complications / Q000188:drug therapy / Q000276:immunology*; D019837:Ryanodine Receptor Calcium Release Channel / Q000276:immunology*; D013945:Thymoma / Q000150:complications / Q000276:immunology; D013953:Thymus Neoplasms / Q000150:complications / Q000276:immunology
D007166:Immunosuppressive Agents; D019837:Ryanodine Receptor Calcium Release Channel