Lectin-like proteins in model organisms: implications for evolution of carbohydrate-binding activity.
Classes of intracellular lectins that recognize core-type structures and mediate intracellular glycoprotein trafficking are present in vertebrates, model invertebrates such as Caenorhabditis elegans and Drosophila melanogaster, plants, and yeasts. Lectins that recognize more complex structures at the cell surface, such as C-type lectins and galectins, are also found in invertebrate organisms as well as vertebrates, but the functions of these proteins have evolved differently in different animal lineages.
Dodd
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RB
Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK.
Drickamer
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K
D000818:Animals; D001665:Binding Sites; D005075:Biological Evolution; D002135:Calcium-Binding Proteins / Q000378:metabolism; D037281:Calnexin; D037282:Calreticulin; D050260:Carbohydrate Metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism; D037161:Galectins; D006388:Hemagglutinins / Q000378:metabolism; D007448:Invertebrates; D037102:Lectins / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D008954:Models, Biological; D037121:Plant Lectins; D010944:Plants; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*; D017527:Receptor, IGF Type 2 / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism; D014714:Vertebrates
D002135:Calcium-Binding Proteins; D037282:Calreticulin; D037161:Galectins; D006388:Hemagglutinins; D037102:Lectins; D037121:Plant Lectins; D011506:Proteins; D017527:Receptor, IGF Type 2; D012261:Ribonucleoproteins; D037281:Calnexin