Endogenous cannabinoid anandamide increases heart resistance to arrhythmogenic effects of epinephrine: role of CB(1) and CB(2) receptors.
Intravenous injection of 10 mg/kg anandamide reduces the incidence and duration of epinephrine-induced arrhythmias in rats. SR141716A and SR144528, antagonists of cannabinoid receptor I and II did not abolish the antiarrhythmic effect of anandamide. These data suggest that the antiarrhythmic effect of anandamide is nonspecific or mediated via unknown cannabinoid receptors, but not associated with activation of cannabinoid receptors I and II.
Ugdyzhekova
D S
DS
Tomsk State Pedagogical University.
Bernatskaya
N A
NA
Stefano
J B
JB
Graier
V F
VF
Tam
S W
SW
Mekhoulam
R
R
D000818:Animals; D001095:Arachidonic Acids / Q000502:physiology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced* / Q000503:physiopathology; D001892:Camphanes / Q000494:pharmacology; D004562:Electrocardiography; D063388:Endocannabinoids; D004837:Epinephrine / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D010880:Piperidines / Q000494:pharmacology; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D043885:Receptor, Cannabinoid, CB2; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug / Q000037:antagonists & inhibitors / Q000502:physiology*; D000077285:Rimonabant
D001095:Arachidonic Acids; D001892:Camphanes; C469526:Cnr2 protein, rat; D063388:Endocannabinoids; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D011720:Pyrazoles; D043885:Receptor, Cannabinoid, CB2; D043882:Receptors, Cannabinoid; D011955:Receptors, Drug; C110630:SR 144528; D000077285:Rimonabant; C078814:anandamide; D004837:Epinephrine