Role of Zafirlukast on skin prick test.
BACKGROUND
Some anti-allergic and anti-asthmatic drugs should be discontinued before skin prick test. But there is no knowledge about zafirlukast effects on skin prick test. We investigate the effects of zafirlukast on cutaneous response to histamine and specific allergens.


METHODS
9 patients suffering from allergic mild asthma or allergic rhinitis and 8 healthy individuals were recruited to the study. All of them took 20 mg zafirlukast twice daily for at least 5 days. Skin prick test was performed before and after treatment by histamine and specific allergens. There was no significant difference between pre- and post-treatment skin prick tests in spite of zafirlukast treatment.


CONCLUSIONS
Zafirlukast does not affect skin reactions against histamine and specific allergens. Diagnostic skin prick test can be performed under zafirlukast treatment.
Cuhadaroglu
C
C
Department of Chest, Istanbul Faculty of Medicine, University of Istanbul, Istanbul, Turkey. cuhad@turk.net or cuhad@yahoo.com
Erelel
M
M
Kiyan
E
E
Ece
T
T
Erkan
F
F
D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000328:Adult; D000485:Allergens; D018927:Anti-Asthmatic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000276:immunology; D016022:Case-Control Studies; D005188:False Negative Reactions; D005260:Female; D006632:Histamine; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis*; D007211:Indoles; D020024:Leukotriene Antagonists / Q000494:pharmacology* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D048448:Phenylcarbamates; D018343:Receptors, Adrenergic, beta-2 / Q000187:drug effects; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy / Q000276:immunology; D012882:Skin Tests; D013449:Sulfonamides; D014105:Tosyl Compounds / Q000494:pharmacology* / Q000627:therapeutic use
D000318:Adrenergic beta-Agonists; D000485:Allergens; D018927:Anti-Asthmatic Agents; D007211:Indoles; D020024:Leukotriene Antagonists; D048448:Phenylcarbamates; D018343:Receptors, Adrenergic, beta-2; D013449:Sulfonamides; D014105:Tosyl Compounds; D006632:Histamine; C062735:zafirlukast