A preliminary study on the analgesic activity of Grangea maderaspatana.
The methanol extract of the whole plant of Grangea maderaspatana showed a dose-dependent analgesic activity. At doses of 1 and 3 g/kg, the extract significantly (P<0.001) inhibited acetic acid-induced writhing in mice by 50 and 80%, respectively.
Ahmed
M
M
Department of Pharmacy, University of Dhaka, Dhakka 1000, Bangladesh. mmn@bpl.net
Islam
M M
MM
Hossain
C F
CF
Khan
O F
OF
D019342:Acetic Acid / Q000009:adverse effects; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D019659:Asteraceae; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D010146:Pain / Q000139:chemically induced / Q000517:prevention & control*; D010147:Pain Measurement / Q000187:drug effects*; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal
D018712:Analgesics, Non-Narcotic; D010936:Plant Extracts; D019342:Acetic Acid