title: Infusion of the metabotropic receptor agonist, DCG-IV, into the main olfactory bulb induces olfactory preference learning in rat pups.
abstract: DCG-IV, a type 2 metabotropic glutamate receptor (mGluR2) agonist, was infused into the main olfactory bulb of 1-week-old pups exposed to peppermint odor. A preference for peppermint was demonstrated 24 h later. The data support the proposal that disinhibition at dendrodendritic synapses between granule cells and mitral cells is a critical component of olfactory memory formation in the rat pup olfactory bulb as well as in the accessory olfactory bulb of adult rodents.
authors: Division of Basic Sciences, Faculty of Medicine, Memorial University of Newfoundland, Health Sciences Centre, St. John's, Newfoundland, Canada A1B 3V6.
authors: J D
authors: JD
authors: Rumsey
authors: A
authors: A
authors: Darby-King
authors: C W
authors: CW
authors: Harley
authors: J H
authors: JH
authors: McLean
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000927:Anticonvulsants / Q000494:pharmacology*; D003213:Conditioning, Psychological / Q000187:drug effects / Q000502:physiology; D003521:Cyclopropanes / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology*; D008568:Memory / Q000187:drug effects / Q000502:physiology; D036142:Mentha piperita; D008845:Microinjections; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009812:Odorants; D009830:Olfactory Bulb / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D018034:Olfactory Receptor Neurons / Q000187:drug effects / Q000502:physiology; D010936:Plant Extracts; D051381:Rats; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists* / Q000502:physiology; D012903:Smell / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
chemical_list: D000927:Anticonvulsants; D003521:Cyclopropanes; D010936:Plant Extracts; D018094:Receptors, Metabotropic Glutamate; C108822:metabotropic glutamate receptor 2; C082313:2-(2,3-dicarboxycyclopropyl)glycine; D005680:gamma-Aminobutyric Acid; D005998:Glycine