A study on the prevention and treatment of myopia with nacre on chicks.
The contents of mineral elements and amino acids in the hydrolysate of the traditional Chinese mineral medicine nacre have been determined. It has long since been proved by the practice of doctors of traditional Chinese medicine that pearl can be used to treat eye diseases. Based on such an understanding, a study is made of the influence of the said medicine on the incidence of myopia. First a form-sense-deprived model (FDM) for chicks is developed and the effect of the said medicine on the elongation of axis oculi is determined with an Abbe's comparator and an A-mode ultrasound instrument. The activity of superoxide dismutase (SOD), nitric oxide synthetase (NOS), and the content of nitric oxide (NO) in the retino-pigmental epithelium choroid homogenate are also analysed. The role of the said traditional Chinese mineral medicine in preventing and treating myopia is explained with respect to the above findings. The results obtained will provide a basis for using nacre, a traditional Chinese mineral medicine, to prevent and treat myopia.
Xu
H
H
Department of Chemistry, Huazhong University of Science and Technology, Wuhan 430074, China. hbxu@mail.hust.edu.cn
Huang
K
K
Gao
Q
Q
Gao
Z
Z
Han
X
X
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002256:Carbonic Anhydrases / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D002645:Chickens; D002829:Choroid / Q000187:drug effects / Q000378:metabolism; D002857:Chromium / Q000378:metabolism; D004195:Disease Models, Animal; D029721:Drosophila Proteins; D019573:Epithelium, Corneal / Q000187:drug effects / Q000378:metabolism; D005123:Eye / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006868:Hydrolysis; D019476:Insect Proteins / Q000378:metabolism; D008516:Medicine, Chinese Traditional; D008670:Metals / Q000494:pharmacology / Q000627:therapeutic use; D009216:Myopia / Q000188:drug therapy / Q000517:prevention & control*; D009569:Nitric Oxide / Q000378:metabolism; D016601:RNA-Binding Proteins; D015032:Zinc / Q000378:metabolism
D000596:Amino Acids; D029721:Drosophila Proteins; D019476:Insect Proteins; D008670:Metals; D016601:RNA-Binding Proteins; D002857:Chromium; C070574:nos protein, Drosophila; D009569:Nitric Oxide; C101387:nacrein; D002256:Carbonic Anhydrases; D015032:Zinc; D002118:Calcium