DNA quadruplexes and dynamical genetics.
In a recent paper, we have put forward the hypothesis that there exist smart purposive mechanisms - tandem repeat length managers - which regulate the length of some tandem repeat, or cause rearrangements, and are almost always driven by some variable number tandem repeat. We have called the framework in which such mechanisms act 'dynamical genetics'. The purpose of this paper is to contribute to lay the foundations of a molecular study of the above mechanisms, by proposing a hypothesis, based on various kinds of supporting evidence and plausibility arguments, about the special importance of DNA quadruplexes for dynamical genetics, and by considering the involved enzymes. This hypothesis states that a tandem repeat length manager acts almost always by monitoring a DNA tract that has the characteristics of being a variable number tandem repeat and/or forming a DNA quadruplex, and that it is almost always driven by at least one of them.
Fonzo
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VD
EuroBioPark c/o Parco Scientifico, Università di Roma 'Tor Vergata', Rome, Italy.
Bersani
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E
Aluffi-Pentini
F
F
Parisi
V
V
D000375:Aging / Q000235:genetics; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics; D004247:DNA / Q000235:genetics*; D006801:Humans; D018598:Minisatellite Repeats; D010272:Parasitic Diseases / Q000235:genetics; D014777:Virus Diseases / Q000235:genetics
D004247:DNA