title: A comparative neuroethological study of limbic seizures induced by Parawixia bistriata venom and kainic acid injections in rats.
abstract: A number of neurotoxins derived from arthropod venoms are known to show highly selective effects on nervous tissue. These neurotoxins have been proved to be extremely useful tools to investigate either convulsive or anticonvulsive mechanisms in the nervous system. In the present work, intracerebroventricular injection of the crude venom from the spider Parawixia bistriata (Araneae, Araneidae) in rats induced convulsive limbic seizures (head and forelimb myoclonus, as well as rearing and falling). Neuroethological analysis showed that the limbic seizures induced by the venom were different from those induced by kainic acid. Intravenous injection of the same venom did not induce seizures, but the neuroethological analysis showed an intensification of grooming behavior similar to a displaced activity. In conclusion, our experiments point that crude venom of P. bistriata may contain convulsant neurotoxins probably acting in limbic system structures. The mechanism of action of these neurotoxins may be different from simple activation of glutamatergic kainate receptors, as evidenced by a comparative neuroethological analysis of seizures induced by either venom or kainic acid.
authors: Programa de Pós-graduação em Psicobiologia, Departamento de Psicologia e Educação, Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto, Universidade de São Paulo, São Paulo, Brazil.
authors: M C
authors: MC
authors: Rodrigues
authors: R
authors: R
authors: Guizzo
authors: W F
authors: WF
authors: dos Santos
authors: N G
authors: NG
authors: Cairasco
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects* / Q000502:physiology; D007608:Kainic Acid / Q000494:pharmacology*; D008032:Limbic System / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D018092:Kainic Acid Receptors / Q000187:drug effects / Q000378:metabolism; D012640:Seizures / Q000139:chemically induced* / Q000503:physiopathology; D012985:Software Design; D013111:Spider Venoms / Q000633:toxicity*
chemical_list: D007608:Kainic Acid; D018092:Kainic Acid Receptors; D013111:Spider Venoms