[Effects of betamethasone administration on maternal-fetal Doppler velocimetry].
BACKGROUND
The effect of antenatal betamethasone on fetal parameters includes a transient reduction of fetal heart rate variation and of fetal body movements. An effect on maternal-fetal blood flow has also been shown, with non-univocal results.


OBJECTIVE
To evaluate the effect of antenatal betamethasone in third trimester singleton high-risk pregnancies by Doppler technology.


METHODS
Thirty-six pregnant women who received a full course of betamethasone (12 mg i.m. two times, 24 hrs apart) were studied. The Doppler examination included the assessment of the pulsatility index (PI) of the umbilical artery (UA PI), the middle cerebral artery (MCA PI) and of resistance index of uterine arteries (Ut RI) before treatment, and 48 and 96 hrs after second dose of betamethasone.


RESULTS
No significant variation was noted in UA PI through betamethasone therapy. MCA PI decreased significantly 48 hours from the last injection of betamethasone (p = 0.004), and returned to basal values at 96 hours. No difference was found for the other Doppler parameters examined. When serial Doppler studies were analyzed according to the gestational age, in the group < 32 wks' gestation, MCA PI decreased significantly after 48 hours (p < 0.006) and returned to pre-treatment values after 96 hours from the last betamethasone dose. Conversely, no difference was found in Doppler serial measurements in any of the analyzed districts in the subgroup > or = 32 wks' gestation.


CONCLUSIONS
Betamethasone treatment is associated with an increase in end diastolic flow of the middle cerebral artery, as reflected by a significant, although transient, reduction of MCA PI, especially at gestational ages < 32 weeks.
Piazze
J
J
2nd Istituto di Obstetrics and Gynecology, University La Sapienza of Rome, Italy. jjpiazze2000@hotmail.com
Anceschi
M
M
Amici
F
F
Vitali
S
S
Cignini
P
P
Terracina
G M
GM
Cosmi
E V
EV
D001623:Betamethasone / Q000494:pharmacology*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D006801:Humans; D017078:Laser-Doppler Flowmetry; D021041:Placental Circulation / Q000187:drug effects*; D011247:Pregnancy
D005938:Glucocorticoids; D001623:Betamethasone