title: [Otosclerosis and Van der Hoeven's syndrome: a contribution].
abstract: Morphological and microchemical changes that effect to the otosclerotic stape in the Van der Hoeve's syndrome were examined with a scanning electron microscope equipped with an energy dispersive X-ray fluorescence. Using the Ca/P ratio as criterion--measured by the characteristic x-ray fluorescence--it was shown that the Van der Hoeve stape had a higher Ca/P ratio (2.6:1) as compared to the normal stape (2:1). The Van der Hoeve's syndrome lesions as poorly mineralized, with low calcium salt and apparent increase of phosphates. This finding indicates a possible change from hydroxyapatite (or apatite) to brushite, which imply an acidification of bone.
authors: Servicio de ORL, Hospital Universitario Río Hortega, C/Cardenal Torquemada, s/n. 47010 Valladolid.
authors: L A
authors: LA
authors: Vallejo Valdezate
authors: J
authors: J
authors: Martín Gil
authors: M
authors: M
authors: José-Yacamán
authors: F J
authors: FJ
authors: Martín Gil
authors: L M
authors: LM
authors: Gil-Carcedo
authors: J L
authors: JL
authors: Herrero Laso
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010040:Otosclerosis / Q000235:genetics* / Q000473:pathology*; D010375:Pedigree; D013050:Spectrometry, Fluorescence; D017550:Spectroscopy, Fourier Transform Infrared; D013199:Stapes / Q000737:chemistry / Q000648:ultrastructure*; D013577:Syndrome