Pharmacokinetic interactions between cyclosporine and bupropion or methylphenidate.
A 10-year-old boy with a history of heart transplantation had a potentially life-threatening decrease in his cyclosporine (CSA) blood levels during administration of bupropion. Subsequently he had an increase in CSA levels while receiving methylphenidate. These occurrences represent potential drug-drug interactions in children not previously documented in the literature. The CSA-bupropion and CSA-methylphenidate interactions merit further investigation, particularly because psychotropic agents are often prescribed in combination with immunosuppressants in transplantation patients of all ages.
Lewis
B R
BR
Nystrom and Associates, New Brighton, Minnesota 55112, USA.
Aoun
S L
SL
Bernstein
G A
GA
Crow
S J
SJ
D018687:Antidepressive Agents, Second-Generation / Q000009:adverse effects* / Q000493:pharmacokinetics*; D001289:Attention Deficit Disorder with Hyperactivity / Q000150:complications / Q000188:drug therapy; D016642:Bupropion / Q000009:adverse effects* / Q000493:pharmacokinetics*; D000697:Central Nervous System Stimulants / Q000009:adverse effects* / Q000493:pharmacokinetics*; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects* / Q000493:pharmacokinetics*; D004347:Drug Interactions; D016027:Heart Transplantation / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects* / Q000493:pharmacokinetics*; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects* / Q000493:pharmacokinetics*
D018687:Antidepressive Agents, Second-Generation; D000697:Central Nervous System Stimulants; D007166:Immunosuppressive Agents; D016642:Bupropion; D008774:Methylphenidate; D016572:Cyclosporine