B cells, BAFF/zTNF4, TACI, and systemic lupus erythematosus.
B cells and B-cell/T-cell collaborations are instrumental in the pathophysiology of systemic lupus erythematosus (SLE). This commentary highlights in particular the newly discovered role of B-cell-activating factor (BAFF; also known as TALL-1, THANK, BlyS, and zTNF4) as a positive regulator of B-cell functions, such as B-cell activation and differentiation. Two members of the tumor necrosis factor(TNF)-receptor superfamily were recently identified as receptors for BAFF on B cells. The interaction between BAFF and its receptors may be important in the pathogenesis of lupus. Advances in our understanding of abnormalities in immune regulation in lupus might provide the opportunity to improve our current therapeutic approaches to this disorder.
Dörner
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Department of Medicine, Charite Berlin, Germany. tdoerner@charite.de
Putterman
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D000818:Animals; D053264:B-Cell Activating Factor; D001402:B-Lymphocytes / Q000502:physiology*; D003511:Cyclohexanols / Q000378:metabolism*; D003514:Cyclohexylamines / Q000378:metabolism*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology*; D008565:Membrane Proteins / Q000502:physiology*; D051379:Mice; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology*
C421443:1,3,5-triamino-2,4,6-trihydroxycyclohexane; D053264:B-Cell Activating Factor; D003511:Cyclohexanols; D003514:Cyclohexylamines; D008565:Membrane Proteins; D018124:Receptors, Tumor Necrosis Factor; C505719:TNFSF13B protein, human; C505720:Tnfsf13b protein, mouse; D014409:Tumor Necrosis Factor-alpha