The effect of cyclosporin A on the activity of matrix metalloproteinases during the healing of rat molar extraction wounds.
Cyclosporin A (CyA) is a cyclic peptide used as an immunosuppressive agent because it can block the synthesis of interleukin-2 and other cytokines produced by CD4+ lymphocytes. It is widely used for the prevention of allograft rejection and treatment of autoimmune diseases. Several side-effects of CyA treatment have been reported, among which are chronic nephrotoxicity, hepatotoxicity and neurotoxicity, lymphoproliferative neoplasms, hypertension, thromboembolic complications and gingival overgrowth. Here, using a rat molar model, it is demonstrated that CyA immunosuppression inhibits the activity of matrix metalloproteinases 2 and 9 in the early phase of granulation tissue in the healing dental socket. These observations suggest that CyA may interfere with the wound healing following dental extractions.
Silva
H C
HC
Department of Oral Pathology and Genetics, School of Dentistry of Piracicaba, UNICAMP, Avenida Limeira 901, 13414-018, CP 52, SP, Piracicaba, Brazil.
Coletta
R D
RD
Jorge
J
J
Bolzani
G
G
de Almeida
O P
OP
Graner
E
E
D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D061965:Matrix Metalloproteinase Inhibitors; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D014081:Tooth Extraction; D020390:Tooth Socket / Q000201:enzymology*; D014945:Wound Healing / Q000187:drug effects*
D007166:Immunosuppressive Agents; D061965:Matrix Metalloproteinase Inhibitors; D016572:Cyclosporine