[Use of magnetosorbents in the immunodiagnosis and therapy of systemic lupus erythematosus and rheumatoid arthritis].
The authors present new technology of producing immobilized granulated antigenic magnetosorbents (MS) using collagen type II, IgG, denaturated DNA and cardiolipin which were employed in enzyme immunoassay for detection of specific antibodies in the blood of patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE). Due to high capacity, MS demonstrated effectiveness in early diagnosis, prognosis of RA and SLE as well as in control over the treatment effects. As shown in in vitro experiments, MS have high selective capacity and atraumaticity for blood corpuscles. MS can be sterilized, regenerated and reused which is a great advantage.
Zborovskiĭ
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Gontar'
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D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D002308:Cardiolipins; D003094:Collagen; D004247:DNA; D003937:Diagnosis, Differential; D006801:Humans; D007124:Immunoenzyme Techniques / Q000379:methods*; D007074:Immunoglobulin G; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D008280:Magnetics; D011237:Predictive Value of Tests; D011379:Prognosis
D002308:Cardiolipins; D007074:Immunoglobulin G; D003094:Collagen; D004247:DNA