title: Effect of continuous infusion of prostaglandin E1 on hepatic blood flow.
abstract: OBJECTIVE
  To evaluate the effects of an intravenous infusion of prostaglandin E1 (PGE1) on hepatic blood flow.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  University-affiliated hospital.
  
  
  METHODS
  16 ASA physical status I and II surgical patients who were scheduled for abdominal surgery.
  
  
  METHODS
  Patients were anesthetized with 1% sevoflurane and 66% nitrous oxide. PGE1 0.05 mg/kg/min or PGE1 0.10 mg/kg/min was continuously infused, followed by an infusion of 1000 mL Ringer's acetate solution.
  
  
  METHODS
  The hemodynamic effect of PGE1 was examined using pulse dye densitometry (PDD). A nose probe for PDD was used, and 10 mg indocyanine green (ICG) in 2 mL distilled water was bolus-infused into a central venous catheter for each measurement. Cardiac output (CO), circulating blood volume (CBV), and plasma dye clearance rate (K) were monitored from the dye-densitogram. Hepatic blood flow was estimated using the K and CBV values.
  
  
  RESULTS
  PGE1 did not increase CBV or CO. Even adding a 1000 mL crystalloid infusion did not expand CBV, whereas mean arterial pressure (MAP) significantly decreased from 91.1 +/- 16.5 mmHg to 84.8 +/- 13.5 mmHg (PGE1 0.05 microg/kg/min) and 80.6 +/- 14.4 mmHg (PGE1 0.10 microg/kg/min ) (p < 0.01 compared with control value), then to 72.0 +/- 6.5 mmHg (PGE1 0.10 microg/kg/min + 1000 mL Ringer's acetate) (p < 0.01 compared with control value). Hepatic blood flow changes were 1.46 +/- 0.60 L/min (control), 1.48 +/- 0.45 L/min (PGE1 0.05 microg/kg/min), 1.14 +/- 0.35 L/min (PGE1 0.10 microg/kg/min), and 1.15 +/- 0.19 L/min (PGE1 0.10 microg/kg/min + 1000 mL Ringer's acetate) (no significant difference, p < 0.05). Hepatic blood flow and K values did not statistically significantly differ at each condition.
  
  
  CONCLUSIONS
  PGE1 does not affect blood volume shift, CO, or hepatic blood flow.
authors: Department of Anesthesiology, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka-City, Japan. iijmt@kyorin-u.ac.jp
authors: T
authors: T
authors: Iijima
authors: F
authors: F
authors: Ohishi
authors: T
authors: T
authors: Tatara
authors: Y
authors: Y
authors: Iwao
mesh_terms: D000527:Alprostadil / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004396:Coloring Agents; D003720:Densitometry; D005260:Female; D006801:Humans; D007208:Indocyanine Green; D008102:Liver Circulation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D004396:Coloring Agents; D014665:Vasodilator Agents; D000527:Alprostadil; D007208:Indocyanine Green