title: Detection of elevated serum beta-chemokine levels in seronegative Chinese individuals exposed to human immunodeficiency virus type 1.
abstract: The mutations in the CCR5 coding region, such as CCR5Delta32 and CCR5m303, that suppress the transmission of human immunodeficiency virus (HIV) type 1 do not exist in Chinese people. However, 9 Chinese subjects in Taiwan with histories of multiple sexual exposures to HIV remained uninfected, suggesting that certain anti-HIV factors do indeed exist. Experiments were therefore designed to investigate the immune mechanism that protects this cohort against HIV infection. Peripheral blood samples from these 9 subjects and 7 healthy people who had not been exposed to HIV were obtained for the quantitation of the levels for beta-chemokines and interleukin 16 (IL-16) in serum samples or secreted by peripheral blood lymphocytes. Significantly higher serum levels for nearly all 3 beta-chemokines, regulation on activation, normal T cell-expressed and secreted, macrophage inflammatory protein (MIP)-1alpha, and MIP-1beta (P<.05, P<.05, and P=.05, respectively), but not IL-16, were detected in the 9 HIV-uninfected subjects as compared with control subjects. The result suggests that among the host genes and cellular factors thus far identified, beta-chemokines are the major HIV-suppressive factors that protect Chinese people from infection with HIV.
authors: Department of Biochemistry, Chung Shan Medical and Dental College, No. 110, Chien-Kuo N. Road, Taichung 402, Taiwan, ROC.
authors: B
authors: B
authors: Shieh
authors: Y P
authors: YP
authors: Yan
authors: N Y
authors: NY
authors: Ko
authors: Y E
authors: YE
authors: Liau
authors: Y C
authors: YC
authors: Liu
authors: H H
authors: HH
authors: Lin
authors: P P
authors: PP
authors: Chen
authors: C
authors: C
authors: Li
mesh_terms: D000328:Adult; D044466:Asian People; D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5 / Q000097:blood; D019742:Chemokines, CC / Q000097:blood*; D005260:Female; D015658:HIV Infections / Q000208:ethnology* / Q000276:immunology; D018023:HIV Seronegativity / Q000276:immunology*; D015497:HIV-1; D006801:Humans; D019410:Interleukin-16 / Q000097:blood; D019402:Macrophage Inflammatory Proteins / Q000097:blood; D008297:Male; D013624:Taiwan
chemical_list: D054405:Chemokine CCL3; D054407:Chemokine CCL4; D018946:Chemokine CCL5; D019742:Chemokines, CC; D019410:Interleukin-16; D019402:Macrophage Inflammatory Proteins