title: Northwest African distribution of the CD4/Alu microsatellite haplotypes.
abstract: We have analysed a linked microsatellite/Alu polymorphism at the CD4 locus (CD4/Alu) in 666 chromosomes from samples of the Iberian Peninsula, Northwest Africa, and West sub-Saharan Africa. The Iberian Peninsula differs from other European populations by its higher levels of haplotype diversity (0.75), and weaker association between the microsatellite allele 90 and Alu(-) chromosomes. These results are explainable by a substantial gene flow from Northwest Africa. Significant geographic clines for the five major haplotypes suggest a south to north migration from sub-Saharan Africa into Northwest Africa. In spite of this, the consistent presence of haplotype 110(-) in this area is congruent with an ancient and autochthonous human presence in Northwest Africa.
authors: Departamento de Genética, Universidad de La Laguna, Spain.
authors: C
authors: C
authors: Flores
authors: N
authors: N
authors: Maca-Meyer
authors: A M
authors: AM
authors: González
authors: V M
authors: VM
authors: Cabrera
mesh_terms: D017954:Africa South of the Sahara; D000352:Africa, Northern; D000354:Africa, Western; D000483:Alleles; D020087:Alu Elements; D015704:CD4 Antigens / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D008297:Male; D018895:Microsatellite Repeats; D011110:Polymorphism, Genetic; D013030:Spain
chemical_list: D015704:CD4 Antigens