Bogorol A produced in culture by a marine Bacillus sp. reveals a novel template for cationic peptide antibiotics.
[figure: see text] Bogorol A (1), a novel peptide antibiotic active against MRSA and VRE, has been isolated from cultures of a marine Bacillus sp. collected in Papua New Guinea. The structure of bogorol A was elucidated by a combination of spectroscopic analyses and chemical degradation. Bogorol A illustrates a new structural template for "cationic peptide antibiotics".
Barsby
T
T
Departments of Chemistry and Earth and Ocean Sciences, University of British Columbia, Vancouver, British Columbia V6T 1Z1, Canada.
Kelly
M T
MT
Gagné
S M
SM
Andersen
R J
RJ
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D001407:Bacillus / Q000378:metabolism*; D002412:Cations; D016983:Enterococcus / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010455:Peptides; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013211:Staphylococcus aureus / Q000187:drug effects; D013698:Templates, Genetic; D020713:Vancomycin Resistance
D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D002412:Cations; D010455:Peptides; C431591:bogorol A