Oxazole synthesis with minimal purification: synthesis and application of a ROMPgel Tosmic reagent.
[figure: see text] The synthesis of ring opening metathesis, polymer-supported Tosmic reagent 1 is described. This reagent was utilized in the conversion of aldehydes to oxazoles in good yields and purities.
Barrett
A G
AG
Department of Chemistry, Imperial College of Science, Technology and Medicine, London, SW7 2AY, United Kingdom. agmb@ic.ac.uk
Cramp
S M
SM
Hennessy
A J
AJ
Procopiou
P A
PA
Roberts
R S
RS
D007202:Indicators and Reagents; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010080:Oxazoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000302:isolation & purification; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D010080:Oxazoles