Anti-inflammatory and anti-ulcer activity of Calligonum comosum in rats.
The 10% ethanol extract of the aerial parts of Calligonum comosum (50--400 mg/kg, i.p.) significantly reduced the increase in hind paw oedema induced by carrageenan in rats. Following sub-acute oral administration of the extract (50 and 100 mg/kg, daily for 14 days), a significant anti-inflammatory activity in the cotton pellet model was observed. Pre-treatment with the extract (100, 200 and 400 mg/kg) produced a significant and dose-dependent inhibition to the acute gastric ulcers induced by phenylbutazone, indomethacin, 0.2 N NaOH and 80% ethanol.
Liu
X M
XM
Department of Pharmacology and Toxicology, Zayed Complex for Herbal Research &Traditional Medicine, Ministry of Health, 29300 Abu Dhabi, United Arab Emirates. liuxm@emirates.net.ae
Zakaria
M N
MN
Islam
M W
MW
Radhakrishnan
R
R
Ismail
A
A
Chen
H B
HB
Chan
K
K
Al-Attas
A
A
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology* / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D000431:Ethanol; D005260:Female; D003368:Gossypium; D015745:Granuloma, Foreign-Body / Q000517:prevention & control*; D007213:Indomethacin; D008297:Male; D010653:Phenylbutazone; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D019664:Polygonaceae; D051381:Rats; D017208:Rats, Wistar; D012972:Sodium Hydroxide; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D000431:Ethanol; D012972:Sodium Hydroxide; D002351:Carrageenan; D010653:Phenylbutazone; D007213:Indomethacin