title: Possibility of potential VWD misdiagnosis or misclassification using LIA technology and due to presence of rheumatoid factor.
abstract: von Willebrand's disease (VWD) is now recognised to be the most common inherited bleeding disorder and is due to defects and/or deficiencies in von Willebrand factor (VWF). The latex immuno-assay (LIA) procedure has become a popular VWF:Ag detection methodology because of the ability to automate testing. In this report, we present findings which urge caution when normal LIA results are obtained co-incident to striking clinical findings strongly suggestive of VWD, or previous laboratory findings consistent with VWD. As illustrated by a relevant case study, normal LIA results may lead to an "incorrect diagnosis" of "not VWD" or to a potential subtype misdiagnosis, should they be accepted without cross-confirmation using alternative VWF methodologies.
authors: Department of Haematology, ICPMR, Westmead Hospital, Australia. emmanuel@icpmr.wsahs.nsw.gov.au
authors: E J
authors: EJ
authors: Favaloro
authors: M
authors: M
authors: Aboud
authors: C
authors: C
authors: Arthur
mesh_terms: D000368:Aged; D001172:Arthritis, Rheumatoid / Q000150:complications*; D001327:Autoimmune Diseases / Q000150:complications*; D003951:Diagnostic Errors; D005188:False Negative Reactions; D006801:Humans; D007841:Latex Fixation Tests; D008297:Male; D012217:Rheumatoid Factor / Q000097:blood*; D014842:von Willebrand Diseases / Q000097:blood / Q000145:classification / Q000150:complications / Q000175:diagnosis*; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D014841:von Willebrand Factor; D012217:Rheumatoid Factor