title: A new multicomponent domino reaction of 1,3-dicarbonyl compounds: one-pot access to polycyclic N/O-, N/S-, and N/N-aminals.
abstract: [reaction: see text] The first multicomponent domino transformation between 1,3-dicarbonyls 1, alpha,beta-unsaturated compounds 2, and functionalized amines 3 is described, providing a one-pot access to fused polyheterocyclic or spiropolyheterocyclic compounds 5 or 6 bearing an aminal function by formation of up to three new cycles, five novel bonds, and up to six stereogenic centers.
authors: Laboratoire RéSo, Réactivité en Synthèse organique, UMR au CNRS 6516, Centre de St. Jérôme, boîte D12, 13397 Marseille Cedex 20, France.
authors: C
authors: C
authors: Simon
authors: J F
authors: JF
authors: Peyronel
authors: J
authors: J
authors: Rodriguez
mesh_terms: D000171:Acrolein / Q000737:chemistry; D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D002384:Catalysis; D003500:Cyclization; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry*; D007659:Ketones / Q000138:chemical synthesis* / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D010881:Piperidones / Q000138:chemical synthesis / Q000737:chemistry; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014867:Water / Q000737:chemistry
chemical_list: D000588:Amines; D006571:Heterocyclic Compounds; D007659:Ketones; D010881:Piperidones; D014867:Water; D000171:Acrolein