title: Mathematical analysis of a mechanism for autonomous metabolic oscillations in continuous culture of Saccharomyces cerevisiae.
abstract: Autonomous metabolic oscillations were observed in aerobic continuous culture of Saccharomyces cerevisiae. Experimental investigation of the underlying mechanism revealed that several pathways and regulatory couplings are involved. Here a hypothetical mechanism including the sulfate assimilation pathway, ethanol degradation and respiration is transformed into a mathematical model. Simulations confirm the ability of the model to produce limit cycle oscillations which reproduce most of the characteristic features of the system.
authors: Humboldt University, Institute of Biology, Theoretical Biophysics, Berlin, Germany. wolf@rz.hu-berlin.de
authors: J
authors: J
authors: Wolf
authors: H
authors: H
authors: Sohn
authors: R
authors: R
authors: Heinrich
authors: H
authors: H
authors: Kuriyama
mesh_terms: D019069:Cell Respiration / Q000502:physiology; D006862:Hydrogen Sulfide / Q000378:metabolism; D008660:Metabolism; D008962:Models, Theoretical; D010766:Phosphorylation; D012441:Saccharomyces cerevisiae / Q000378:metabolism* / Q000502:physiology; D013431:Sulfates / Q000378:metabolism
chemical_list: D013431:Sulfates; D006862:Hydrogen Sulfide