Lupus anticoagulant and protein S deficiency in a child who developed disseminated intravascular coagulation in association with varicella.
Varicella is not always a benign disease it may cause serious complications. We report a two-year-old boy with disseminated intravascular coagulation in association with varicella. The patient had the lupus anticoagulant, the antiphospholipid antibody, acquired free protein S deficiency, and increased concentrations of the prothrombin F 1+2 fragment. Intravenous immunoglobulin was administered due to its potential antibody-blocking activity, and the patient responded well. We recommend that children with varicella and disseminated intravascular coagulation should be examined for the lupus anticoagulant, the free protein S antigen, the prothrombin fragment F 1+2 and the other coagulation parameters. Intravenous immunoglobulin administration could be useful in such conditions because of its antibody-blocking activity.
Kurugöl
Z
Z
Department of Pediatrics, Ege University Faculty of Medicine, Izmir, Turkey.
Vardar
F
F
Ozkinay
F
F
Kavakli
K
K
Cetinkaya
B
B
Ozkinay
C
C
D002644:Chickenpox / Q000097:blood / Q000150:complications*; D002675:Child, Preschool; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology*; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000032:analysis*; D008297:Male; D018455:Protein S Deficiency / Q000097:blood / Q000150:complications*
D016682:Lupus Coagulation Inhibitor