Fused heterocyclic antioxidants: antioxidative activities of hydrocoumarins in a homogeneous solution.
We compared the antioxidative activities of seven hydrocoumarins with those of alpha-tocopherol for the oxidation of tetralin and linoleic acid in a homogeneous solution. Hydrocoumarins exhibited a higher induction period than that of alpha-Toc in both systems. However, the rate of oxygen absorption during the induction period for alpha-Toc was slower than that of the hydrocoumarins in both systems. In addition, 6,7-dihydroxy-4,4-dimethylhydrocoumarin showed less cytotoxicity toward human fibroblasts than did 2,6-di-t-butyl-4-methylphenol.
Nishiyama
T
T
Department of Applied Chemistry, Faculty of Engineering and High Technology Research Center, Kansai University, Suita, Osaka, Japan. organic@ipcku.kansai-u.ac.jp
Ohnishi
J
J
Hashiguchi
Y
Y
D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002478:Cells, Cultured; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D016166:Free Radical Scavengers; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D010084:Oxidation-Reduction; D010545:Peroxides / Q000737:chemistry; D012996:Solutions; D024502:alpha-Tocopherol / Q000494:pharmacology
D000975:Antioxidants; D003374:Coumarins; D016166:Free Radical Scavengers; D010545:Peroxides; D012996:Solutions; D024502:alpha-Tocopherol