Interleukin-12 (IL-12) and IL-18 are important in innate defense against genital herpes simplex virus type 2 infection in mice but are not required for the development of acquired gamma interferon-mediated protective immunity.
Using a combination of gene-targeted mice and neutralizing antibodies, we showed that interleukin-12 (IL-12) and IL-18 are important in the innate control of genital herpes simplex virus type 2 infection but were not found to be critical, either singly or in combination, for the development of a protective gamma interferon-mediated immune response.
Harandi
A M
AM
Department of Medical Microbiology and Immunology, Göteborg University, Guldhedsgatan 10A, 413 46 Göteborg, Sweden.
Svennerholm
B
B
Holmgren
J
J
Eriksson
K
K
D000818:Animals; D004195:Disease Models, Animal; D006558:Herpes Genitalis / Q000276:immunology* / Q000517:prevention & control / Q000821:virology; D018258:Herpesvirus 2, Human / Q000276:immunology*; D007113:Immunity, Innate; D007371:Interferon-gamma / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D018664:Interleukin-12 / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D020382:Interleukin-18 / Q000172:deficiency / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D014611:Vaccination
D020382:Interleukin-18; D018664:Interleukin-12; D007371:Interferon-gamma