title: Progress toward a rationally designed molecular motor.
abstract: A retrospective overview of the work in the author's laboratory leading to a prototype (43a) of a chemically powered molecular motor is provided. Beginning with a molecular brake (23) and then proceeding through a molecular "ratchet" (31), the development of a rationally designed molecular motor is described. The thermodynamic underpinnings of the concept are outlined, the synthetic routes to 23, 31, and 43a, are summarized, and the data documenting the function of 23, 31, and 43a are presented.
authors: Eugene F. Merkert Chemistry Center, Department of Chemistry, Boston College, Chestnut Hill, Massachusetts 02467, USA.
authors: T R
authors: TR
authors: Kelly
mesh_terms: D015195:Drug Design; D008958:Models, Molecular; D020409:Molecular Motor Proteins / Q000737:chemistry*; D011083:Polycyclic Compounds / Q000138:chemical synthesis / Q000737:chemistry; D013816:Thermodynamics
chemical_list: D020409:Molecular Motor Proteins; D011083:Polycyclic Compounds