title: Intrinsic and environmental influences on immune senescence in the aged monkey.
abstract: Several factors associated with the age-related decline in immunity were examined in three studies on aged rhesus monkeys. Natural killer (NK) cell activity was found to be low in many monkeys after 20 years of age, but exceptionally long-lived animals, older than 25 years, often had vigorous cytolytic responses. When NK activity was decreased in an aged monkey, it was predictive of fewer years of survival and a younger age at death. This prediction of mortality was associated with one nonimmune biomarker of aging in the monkey: nail growth rate. Monkeys with very slow nail growth and low NK activity were likely to die sooner. Although these findings might suggest an immutable course for the aging process, the housing conditions of old monkeys also had a pronounced effect on their NK activity. The highest NK responses were found in old monkeys housed with just one other old animal when compared to living alone or with just a young, juvenile monkey. It remains to be determined whether this type of psychosocial influence could have a sustained effect on immunity and ultimately change the pace of aging and time to mortality.
authors: Department of Psychology, University of Wisconsin, 1202 West Johnson Street, Madison, WI 53706, USA. ccoe@facstaff.wisc.edu
authors: C L
authors: CL
authors: Coe
authors: W B
authors: WB
authors: Ershler
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology / Q000502:physiology; D018655:Lymphocyte Count; D008214:Lymphocytes / Q000276:immunology; D008253:Macaca mulatta; D008297:Male; D009262:Nails / Q000254:growth & development; D012931:Social Environment