title: Modified Glenn connection for acutely ischemic right ventricular failure reverses secondary left ventricular dysfunction.
abstract: BACKGROUND
  Right heart failure after cardiopulmonary bypass can result in severe hemodynamic compromise with high mortality, but the underlying mechanisms remain poorly understood. After ischemia-induced right ventricular failure, alterations in the interventricular septal position decrease left ventricular compliance and limit filling but may also distort left ventricular geometry and compromise contractility and relaxation. This study investigated the effect of acute isolated right ventricular ischemia on biventricular performance and interaction and the response of subsequent right ventricular unloading by use of a modified Glenn shunt.
  
  
  METHODS
  In 8 pigs isolated right ventricular ischemic failure was induced by means of selective coronary ligation. A modified Glenn circuit was then established by a superior vena cava-pulmonary artery connection. Ventricular performance was determined by conductance catheter-derived right ventricular pressure-volume loops and left ventricular pressure-segment length loops. Hemodynamic data at baseline, after right ventricular ischemia, and after institution of the Glenn circuit were obtained during inflow occlusion, and the load-independent contractile indices were derived.
  
  
  RESULTS
  Right ventricular free-wall ischemia resulted in acute right ventricular dilation (118 +/- 81 mL vs 169 +/- 70 mL, P =.0008) and impairment of left ventricular contractility indicated by the reduced end-systolic pressure-volume relation slope (50.0 +/- 19 mm Hg/mm vs 18.9 +/- 8 mm Hg/mm, P =.002) and preload recruitable stroke work index slope (69.6 +/- 26 erg x cm(-3) x 10(3) vs 39.7 +/- 13 erg x cm(-3) x 10(3), P =.003). In addition, left ventricular relaxation (tau) was significantly prolonged (33.3 +/- 10 ms vs 53.0 +/- 16 ms, P =.012). Right ventricular unloading with the Glenn shunt reduced right ventricular dilation and significantly improved left ventricular contraction, end-systolic pressure-volume relation slope (18.9 +/- 8 mm Hg/mm vs 35.8 +/- 18 mm Hg/mm, P =.002), preload recruitable stroke work index slope (39.7 +/- 26 erg x cm(-3) x 10(3) vs 63.0 +/- 22 erg x cm(-3) x 10(3), P =.003), and diastolic performance (tau 53.0 +/- 16 ms vs 43.5 +/- 13 ms, P =.001).
  
  
  CONCLUSIONS
  Right ventricular ischemia-induced dilation resulted in acute impairment of left ventricular contractility and relaxation. A modified Glenn shunt attenuated the left ventricular dysfunction by limiting right ventricular dilation and restoring left ventricular cavity geometry.
authors: Department of Cardiac Surgery, Brigham and Women's Hospital/Harvard Medical School, Boston, MA, USA.
authors: M H
authors: MH
authors: Danton
authors: J G
authors: JG
authors: Byrne
authors: K Q
authors: KQ
authors: Flores
authors: M
authors: M
authors: Hsin
authors: J S
authors: JS
authors: Martin
authors: R G
authors: RG
authors: Laurence
authors: L H
authors: LH
authors: Cohn
authors: L
authors: L
authors: Aklog
mesh_terms: D000818:Animals; D003971:Diastole; D004108:Dilatation, Pathologic; D004195:Disease Models, Animal; D005260:Female; D018610:Heart Bypass, Right; D006352:Heart Ventricles / Q000473:pathology; D006439:Hemodynamics; D008297:Male; D017202:Myocardial Ischemia / Q000150:complications; D013552:Swine; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000601:surgery*; D018497:Ventricular Dysfunction, Right / Q000209:etiology / Q000601:surgery*