title: Mesityllithium as a reagent for chemoselective halogen-lithium exchange reaction.
abstract: [figure: see text] Mesityllithium was found to be an excellent selective lithiating agent to prepare aryllithium compounds having alkoxycarbonyl groups. To extend our studies on chemoselective lithiation, an important precursor for the synthesis of camptothecin was prepared using a halogen-lithium exchange reaction followed by an intramolecular 1,2-addition.
authors: Graduate School of Pharmaceutical Sciences, Tohoku University, Aobayama, Aoba-ku, Sendai 980-8578, Japan. ykondo@mail.pharm.tohoku.ac.jp
authors: Y
authors: Y
authors: Kondo
authors: M
authors: M
authors: Asai
authors: T
authors: T
authors: Miura
authors: M
authors: M
authors: Uchiyama
authors: T
authors: T
authors: Sakamoto
mesh_terms: D002166:Camptothecin / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D002384:Catalysis; D006846:Hydrocarbons, Halogenated / Q000737:chemistry*; D008094:Lithium / Q000737:chemistry*; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D006846:Hydrocarbons, Halogenated; D009942:Organometallic Compounds; C430850:mesityllithium; D008094:Lithium; D002166:Camptothecin