title: Biphenyls as surrogates of the steroidal backbone. Part 1: synthesis and estrogen receptor affinity of an original series of polysubstituted biphenyls.
abstract: In the course of a programme aimed at discovering new ligands of the estrogen receptor, we explored a series of substituted biphenyls. Their synthesis and binding affinity are described.
authors: Medicinal Chemistry, Aventis, 102 route de Noisy, 93235 Cedex, Romainville, France. dominique.lesuisse@aventis.com
authors: D
authors: D
authors: Lesuisse
authors: E
authors: E
authors: Albert
authors: F
authors: F
authors: Bouchoux
authors: E
authors: E
authors: Cérède
authors: J M
authors: JM
authors: Lefrançois
authors: M O
authors: MO
authors: Levif
authors: S
authors: S
authors: Tessier
authors: B
authors: B
authors: Tric
authors: G
authors: G
authors: Teutsch
mesh_terms: D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D047628:Estrogen Receptor alpha; D006801:Humans; D011960:Receptors, Estrogen / Q000187:drug effects*; D011994:Recombinant Proteins / Q000187:drug effects; D013256:Steroids / Q000737:chemistry*
chemical_list: D001713:Biphenyl Compounds; D047628:Estrogen Receptor alpha; D011960:Receptors, Estrogen; D011994:Recombinant Proteins; D013256:Steroids