Rhodium complex-catalyzed reaction of isonitriles with carbonyl compounds: catalytic synthesis of pyrroles.
[figure: see text] Low-valent rhodium complexes are efficient catalysts for the activation of alpha-C-H bond of isonitriles. Addition of isonitriles to carbonyl compounds proceeds under mild and neutral conditions to give the corresponding alpha,beta-unsaturated formamides. Catalytic synthesis of pyrroles can be performed by cyclocondensation of isonitriles with 1,3-dicarbonyl compounds.
Takaya
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Department of Chemistry, Graduate School of Engineering Science, Osaka University, 1-3 Machikaneyama, Toyonaka, Osaka 560-8531, Japan.
Kojima
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Murahashi
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