title: Sodium fusidate (fusidin) ameliorates the course of monophasic experimental allergic encephalomyelitis in the Lewis rat.
abstract: We have evaluated the effect of the immunosuppressant sodium fusidate (fusidin) on the course of acute monophasic experimental encephalomyelitis (EAE) in male Lewis rats. Prophylactic treatment with fusidin, 80 or 120 mg/kg bd wt., markedly ameliorated the course of the disease in rats immunized with myelin basic proteins in complete Freund's adjuvant, entailing delayed onset of symptoms, lower clinical scores and more rapid recovery than PBS-treated control rats. The fusidin-treated, immunized rats exhibited milder mononuclear cell infiltration of brains and spinal cords than control animals. These data provide further evidence for the anti-inflammatory effect of fusidin and suggest that this drug may be valuable for the treatment of human multiple sclerosis.
authors: Department of Microbiological and Gynaecological Sciences, University of Catania, Catania, Italy.
authors: R
authors: R
authors: Di Marco
authors: G
authors: G
authors: Puglisi
authors: G
authors: G
authors: Papaccio
authors: A
authors: A
authors: Nicoletti
authors: F
authors: F
authors: Patti
authors: A
authors: A
authors: Reggio
authors: K
authors: K
authors: Bendtzen
authors: F
authors: F
authors: Nicoletti
mesh_terms: D000818:Animals; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000188:drug therapy* / Q000473:pathology; D005672:Fusidic Acid / Q000494:pharmacology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008297:Male; D051381:Rats
chemical_list: D007166:Immunosuppressive Agents; D005672:Fusidic Acid