CD20-positive adult T-cell leukemia.
A 67-year-old woman was admitted to our hospital because of lymphadenopathy and lymphocytosis. Monoclonal integration of HTLV-I provirus DNA was detected, and a diagnosis of adult T-cell leukemia (ATL) was made. Flow cytometry revealed that the ATL cells expressed CD20 as well as T-cell-associated antigens, and expression of CD20 mRNA was also demonstrated. A novel T-cell subpopulation expressing CD20 molecules has recently been identified. This is the first report of CD20-positive ATL, suggesting that HTLV-I can infect and transform CD20-positive T cells.
Yasukawa
M
M
First Department of Internal Medicine, Ehime University School of Medicine, Shigenobu, Japan. yasukawa@m.ehime-u.ac.jp
Arai
J
J
Kakimoto
M
M
Sakai
I
I
Kohno
H
H
Fujita
S
S
D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D015139:Blotting, Southern; D002472:Cell Transformation, Viral; D005260:Female; D005434:Flow Cytometry; D015322:Gene Rearrangement, B-Lymphocyte; D015368:Human T-lymphotropic virus 1 / Q000302:isolation & purification*; D006801:Humans; D016130:Immunophenotyping; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000378:metabolism / Q000821:virology*; D014411:Neoplastic Stem Cells / Q000737:chemistry* / Q000821:virology; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016176:T-Lymphocyte Subsets / Q000737:chemistry* / Q000821:virology
D018951:Antigens, CD20; D000951:Antigens, Neoplasm