The envelope of Mason-Pfizer monkey virus has immunosuppressive properties.
We have demonstrated previously that the envelope protein of a murine retrovirus, Moloney murine leukaemia virus, has immunosuppressive properties in vivo. This property was manifested by the ability of the protein, when expressed by tumour cells normally rejected by engrafted mice, to allow the env-expressing cells to escape immune rejection and to proliferate. Here, it is shown that this property is not restricted to the envelope of a murine retrovirus, but is also shared by the envelope encoded by a primate retrovirus, Mason-Pfizer monkey virus.
Blaise
Sandra
S
Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eukaryotes Supérieurs, UMR 1573 CNRS, Institut Gustave Roussy, 94805 Villejuif, France1.
Mangeney
Marianne
M
Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eukaryotes Supérieurs, UMR 1573 CNRS, Institut Gustave Roussy, 94805 Villejuif, France1.
Heidmann
Thierry
T
Unité des Rétrovirus Endogènes et Eléments Rétroïdes des Eukaryotes Supérieurs, UMR 1573 CNRS, Institut Gustave Roussy, 94805 Villejuif, France1.
D000595:Amino Acid Sequence; D000818:Animals; D007121:Immunocompetence; D007165:Immunosuppression Therapy; D016093:Mason-Pfizer monkey virus / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009154:Mutation; D012192:Retroviridae Infections / Q000276:immunology; D014162:Transfection; D014407:Tumor Cells, Cultured; D014412:Tumor Virus Infections / Q000276:immunology; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology*
D014759:Viral Envelope Proteins