[Changes of nitric oxide system during acute myocardial ischemic reperfusion].
The reciprocal changes of NOS and arginase activity during acute myocardial ischaemia (90 min) and reperfusion (180 min) was shown in experiments on chest-closed dogs with spontaneous breathing. NOS activity in the ischemia injured myocardial decreased on 60% while arginase activity increased on 487%. Levels of both alternative pathways of L-arginine metabolism altered reciprocally too. NO2(-)-level was reduced on 57%, and urea level increased on 665%. The same changes were in arterial blood, started from 10 min of ischemia. These changes can play an important role for development of acute ischaemia treatment.
Moĭbenko
O O
OO
A.A. Bogomoletz Institute of Physiology, National Academy of Science of Ukraine, Kiev.
Iuz'kiv
M Ia
MIa
Kotsiuruba
A V
AV
Bukhanevych
O M
OM
Tumanovs'ka
L V
LV
D000818:Animals; D001120:Arginine / Q000378:metabolism; D004195:Disease Models, Animal; D004285:Dogs; D017202:Myocardial Ischemia / Q000097:blood / Q000378:metabolism* / Q000652:urine; D015425:Myocardial Reperfusion; D009569:Nitric Oxide / Q000378:metabolism*
D009569:Nitric Oxide; D001120:Arginine