title: Traceless solid-phase synthesis of substituted benzimidazoles via a base-cleavable linker.
abstract: [figure: see text] A solid-phase route to substituted benzimidazoles has been developed using a modified base-labile linker strategy to release the final products in a traceless manner. This approach permits the synthesis of diverse compounds in moderate yields and high purity.
authors: Affymax Research Institute, 4001 Miranda Avenue, Palo Alto, California 94304, USA. david_tumelty@affymax.com
authors: D
authors: D
authors: Tumelty
authors: K
authors: K
authors: Cao
authors: C P
authors: CP
authors: Holmes
mesh_terms: D000588:Amines / Q000737:chemistry; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013329:Structure-Activity Relationship
chemical_list: D000588:Amines; D001562:Benzimidazoles