title: Otological manifestations of acute leukaemia: report of two cases and review of literature.
abstract: Otological manifestations exceptionally reveal acute leukaemia, whereas leukaemic infiltration of any tissue is frequent at postmortem examination. We present two cases of acute myeloblastic leukaemia revealed by a loss of hearing due to a middle-ear leukaemic infiltration. The characteristics of such a clinical and radiological finding are emphasized. It is suggested that middle and inner ear can be a 'sanctuary' localization, which might sometimes require radiation therapy to achieve durable and complete remission.
authors: Department of Internal Medicine, Hôpitaux Universitaires de Strasbourg, France. emmanuel.andres@chru-strasbourg.fr
authors: E
authors: E
authors: Andrès
authors: J E
authors: JE
authors: Kurtz
authors: F
authors: F
authors: Maloisel
authors: P
authors: P
authors: Dufour
mesh_terms: D000328:Adult; D003131:Combined Modality Therapy; D003638:Deafness / Q000209:etiology; D004432:Ear, Middle / Q000473:pathology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology*; D017254:Leukemic Infiltration / Q000150:complications / Q000175:diagnosis* / Q000628:therapy; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed