title: Prognostic significance of carcinoembryonic antigen levels in peritoneal washes in patients with gastric cancer.
abstract: BACKGROUND
  Peritoneal metastasis is the most frequent cause of death in patients with gastric cancer. Detection of free cancer cells in the peritoneal cavity at the time of surgery, therefore, is considered to be of great value in predicting the peritoneal recurrence and accordingly in the prognosis in patients with gastric cancer. This study examined the clinical significance of intraoperative determination of carcinoembryonic antigen (CEA) levels in peritoneal washes (pCEA) in patients with gastric cancer.
  
  
  METHODS
  CEA levels in peritoneal washes were correlated retrospectively with several clinicopathologic factors including clinical outcome in 56 patients with resectable gastric cancer.
  
  
  RESULTS
  Among several clinicopathologic factors, the depth of tumor invasion significantly and independently correlated with pCEA levels as revealed by multivariate stepwise logistic regression analysis. A significant difference in overall survival rates was observed between pCEA-positive and pCEA-negative groups: 5-year survival rates were 95.7% in pCEA-negative and 20% in pCEA-positive patients (P <0.0001). Multivariate analysis indicated that pCEA level is a statistically significant independent prognostic factor for the survival of patients with gastric cancer, and is an important factor for predicting peritoneal recurrence.
  
  
  CONCLUSIONS
  pCEA could be a potential predictor of a poor prognosis as well as peritoneal recurrence in patients with gastric cancer. We believe that this information could contribute to determining the optimal intraoperative and postoperative therapeutic plan including adjuvant chemotherapy of gastric cancer.
authors: First Department of Surgery, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka City, 181-8611, Tokyo, Japan. abenbtg@kyorin-u.ac.jp
authors: N
authors: N
authors: Abe
authors: T
authors: T
authors: Watanabe
authors: H
authors: H
authors: Toda
authors: H
authors: H
authors: Machida
authors: K
authors: K
authors: Suzuki
authors: T
authors: T
authors: Masaki
authors: T
authors: T
authors: Mori
authors: M
authors: M
authors: Sugiyama
authors: Y
authors: Y
authors: Atomi
authors: Y
authors: Y
authors: Nakaya
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001202:Ascitic Fluid / Q000737:chemistry* / Q000166:cytology; D014408:Biomarkers, Tumor / Q000032:analysis; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D010533:Peritoneal Lavage; D010534:Peritoneal Neoplasms / Q000175:diagnosis / Q000556:secondary*; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors; D012680:Sensitivity and Specificity; D013274:Stomach Neoplasms / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D002272:Carcinoembryonic Antigen