[Expression of the proopiomelanocortin gene in the hypophysis of NICAG-line hypertensive rats].
Expression of the proopiomelanocortin (POMC) gene in NISAG rats with inherited stress-induced arterial hypertension has been investigated by the reverse transcription-competitive PCR method. Normotensive rats of the inbred Wistar albino Glaxo (WAG) strain have been used as control. The effect of 3 h immobilization stress has been examined. The content of POMC mRNA in pituitaries of stressed NISAG rats exceeds that in non-stressed rats of the same strain by a factor of 2.4. Rats of the WAG strain do not demonstrate a significant increase in the level of POMC mRNA. In addition, the basIC transcription level of the POMC gene in NISAG rats is higher than in WAG ones.
Khvorostova
Iu V
IuV
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090 Russia.
Filipenko
M L
ML
Dymshits
G M
GM
Markel'
A L
AL
D000818:Animals; D015870:Gene Expression; D006973:Hypertension / Q000235:genetics*; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D011333:Pro-Opiomelanocortin / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats
D012333:RNA, Messenger; D011333:Pro-Opiomelanocortin