Comparison of recombinant and urinary follicle-stimulating hormone preparations in short-term gonadotropin releasing hormone agonist protocol for in vitro fertilization-embryo transfer.
OBJECTIVE
To compare the efficiency and efficacy of two recombinant human FSH (r-FSH) and urinary (u-FSH) preparations in patients undergoing superovulation for IVF-ET using a short-term gonadotropin releasing hormone agonist (GnRH-a) (Triptorelin) protocol.


METHODS
A total of 88 women undergoing IVF-ET were included in this prospective study. They were randomized to receive u-FSH (150 IU/d), follitropin-alpha (100 IU/d), or follitropin-beta (100 IU/d) for 2 days, and dosages were subsequently adjusted according to the ovarian response.


RESULTS
The FSH dose required for the overall stimulation was significantly lower in patients treated with r-FSH than in those treated with u-FSH while serum FSH values were higher in the latter group. There were no statistically significant differences in ovarian response and IVF outcome between r-FSH preparations.


CONCLUSIONS
Recombinant FSH preparations have a higher efficiency than urinary ones in patients undergoing IVF-ET using a short-term GnRH-a protocol. In this situation, the two recombinant follitropins have comparable effectiveness.
Hugues
J N
JN
Reproductive Medecine Unit, Department of Gynaecology and Obstetrics, University Paris XIII, France. jean-noel.hugues@jvr.ap-hop-paris.fr
Bry-Gauillard
H
H
Bständig
B
B
Uzan
M
M
Cedrin-Durnerin
I
I
D000293:Adolescent; D000328:Adult; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000494:pharmacology* / Q000652:urine*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000187:drug effects; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D011897:Random Allocation; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013480:Superovulation / Q000187:drug effects; D013997:Time Factors
D011994:Recombinant Proteins; D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone