title: A case of meningeal myeloma presenting as obstructive hydrocephalus--a therapeutic challenge.
abstract: Meningeal involvement in myeloma is a rare though recognised complication, and previous treatment strategies have included radiotherapy, intra-thecal and systemic chemotherapy to which there is almost universally a poor response. We report a case of a 60-year-old lady in serological remission with IgG lambda myeloma, presenting with obstructive hydrocephalus due to meningeal infiltration treated with neurosurgical decompression. Such presentation and the treatment strategies are previously unreported, though in view of the ultimate resistance to treatment the prognosis remains poor.
authors: Department of Haematology, Royal Liverpool University Hospital, UK.
authors: M
authors: M
authors: Dennis
authors: P
authors: P
authors: Chu
mesh_terms: D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D006849:Hydrocephalus / Q000175:diagnosis* / Q000601:surgery; D008577:Meningeal Neoplasms / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D009101:Multiple Myeloma / Q000175:diagnosis*