Chronic urticaria associated with intra-articular methylprednisolone.
Reports of allergic reactions following treatment with systemic corticosteroids are rare, despite their widespread use. A 47-year-old man developed widespread urticaria, resistant to antihistamines, coinciding with injections of local anaesthetic and methylprednisolone for cervical spondylosis. He underwent immediate and delayed hypersensitivity tests. Intradermal tests showed immediate-type sensitivity to methylprednisolone and hydrocortisone. Patch tests were positive to 21 of 26 corticosteroids tested. A diagnosis of both an immediate and a delayed-type hypersensitivity to corticosteroids was made. With avoidance of all corticosteroids he has been free from urticarial rash for 9 months and has been able to stop all medication.
Pollock
B
B
Department of Dermatology, Leeds General Infirmary, Leeds LS1 3EX, UK.
Wilkinson
S M
SM
MacDonald Hull
S P
SP
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002908:Chronic Disease; D003875:Drug Eruptions / Q000209:etiology*; D005938:Glucocorticoids; D006801:Humans; D007270:Injections, Intra-Articular; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D014581:Urticaria / Q000139:chemically induced*
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D008775:Methylprednisolone