A thioesterase for chemoselective hydrolysis of S-acyl sulfanylalkanoates.
[figure: see text] A thioesterase, isolated from a strain of Alcaligenes sp. ISH108, chemoselectively hydrolyzes thiol esters. The application of the enzyme has been demonstrated in the preparation of the antihypertensive agent captopril.
Kumar
I
I
Department of Chemistry, Institute of Microbial Technology, Sector 39, Chandigarh 160 036, India.
Jolly
R S
RS
D000421:Alcaligenes / Q000201:enzymology*; D000473:Alkanes / Q000737:chemistry / Q000493:pharmacokinetics*; D000959:Antihypertensive Agents / Q000138:chemical synthesis; D002216:Captopril / Q000138:chemical synthesis; D002625:Chemistry, Organic / Q000379:methods; D006868:Hydrolysis; D007202:Indicators and Reagents; D013379:Substrate Specificity; D013457:Sulfur Compounds / Q000737:chemistry; D013869:Thiolester Hydrolases / Q000378:metabolism*
D000473:Alkanes; D000959:Antihypertensive Agents; D007202:Indicators and Reagents; D013457:Sulfur Compounds; D002216:Captopril; D013869:Thiolester Hydrolases