Relative reactivity of anti- and syn-oximino carbonates and carbamates of 2-pyridylacetic acid esters.
[reaction: see text]anti-Oximes of 2-pyridylacetic acid esters are rapidly transformed to pyridine-2-carbonitrile under a variety of conditions while syn-oximes bearing tert-butyl esters can be conveniently deprotected to the corresponding carboxylic acid with subsequent fragmentation to the nitrile.
Kim
H Y
HY
Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
Lantrip
D A
DA
Fuchs
P L
PL