title: Selective estrogen receptor modulators: from bench to bedside and back.
abstract: OBJECTIVE
  To provide a brief review of the history of the development of selective estrogen receptor modulators (SERMs), the current data assessing the effect of SERMs at the organ level, and the mechanism of action of these agents.
  
  
  METHODS
  All the pertinent medical literature was reviewed, and the effects of SERMs on various end-organs were summarized.
  
  
  RESULTS
  SERMs have been available for clinical use since the late 1960s. By the late 1980s, several SERMs had become available that influenced clinical practice. Multiorgan effects of these compounds include variable clinical efficacy for treatment of menopausal symptoms involving the central nervous system, variable effects on the genitourinary tract, and, in general, positive effects on serum lipid levels. SERMs seem to affect bone density positively, albeit to variable degrees, depending on the agent being used. The greatest effect of SERMs has been on the breast, and current SERMs seem to have efficacy for prevention of breast cancer as opposed to the controversial effect of estrogen on the breast. Disadvantages of SERMs include exacerbation of menopausal symptoms and, as with estrogen, an increased incidence of venous thrombosis and pulmonary emboli. SERMs act by modifying the configuration of the estrogen receptor. Effects at the gene transcription level seem to be tissue specific, a factor that likely accounts for the variability of clinical action seen.
  
  
  CONCLUSIONS
  SERMs are a viable option for treatment of various problems associated with menopause.
authors: Division of Endocrinology, Mayo Clinic, Scottsdale, AZ 85259, USA
authors: M D
authors: MD
authors: Whitaker
mesh_terms: D015519:Bone Density / Q000187:drug effects; D001943:Breast Neoplasms / Q000517:prevention & control; D002318:Cardiovascular Diseases / Q000517:prevention & control; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D011960:Receptors, Estrogen / Q000187:drug effects / Q000235:genetics; D020845:Selective Estrogen Receptor Modulators / Q000494:pharmacology / Q000627:therapeutic use*; D014566:Urogenital System / Q000187:drug effects
chemical_list: D008055:Lipids; D011960:Receptors, Estrogen; D020845:Selective Estrogen Receptor Modulators