title: Effects of 22K or 20K human growth hormone on lipolysis, leptin production in adipocytes in the presence and absence of human growth hormone binding protein.
abstract: OBJECTIVE
  We studied the effects of human growth hormone (hGH) on leptin production and lipolysis stimulation in the presence or absence of human growth hormone binding protein (hGHBP) using 3T3- L1-hGHR adipocytes which efficiently express human growth hormone receptor.
  
  
  CONCLUSIONS
  It was clarified that (1) hGH decreases leptin secretion after hGH-induced lipolysis stimulation, and (2) the reduction of leptin production and lipolysis stimulation by 22K hGH was attenuated with hGHBP, whereas that by 20K hGH, which is a naturally occurring isoform of 22K hGH, was not affected with hGHBP.
authors: Pharmaceuticals Group, Life Science Laboratory, Mitsui Chemicals, Inc., Mobara-shi, Chiba, Japan. noriaki.asada@mitsui-chem.co.jp
authors: N
authors: N
authors: Asada
authors: Y
authors: Y
authors: Takahashi
authors: M
authors: M
authors: Honjo
mesh_terms: D016475:3T3 Cells; D017667:Adipocytes / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D002352:Carrier Proteins / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D015870:Gene Expression; D019382:Human Growth Hormone / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D020738:Leptin / Q000096:biosynthesis*; D008066:Lipolysis / Q000187:drug effects*; D051379:Mice; D008970:Molecular Weight; D054411:Receptors, Leptin; D011986:Receptors, Somatotropin / Q000235:genetics
chemical_list: D002352:Carrier Proteins; D005230:Fatty Acids, Nonesterified; C515448:LEPR protein, human; D020738:Leptin; D054411:Receptors, Leptin; D011986:Receptors, Somatotropin; C515447:leptin receptor, mouse; D019382:Human Growth Hormone; C051815:somatotropin-binding protein