title: Current indoor allergen levels of fungi and cats, but not house dust mites, influence allergy and asthma in adults with high dust mite exposure.
abstract: We assessed the influence of current indoor levels of fungi, house dust mite allergen (Der p 1), and cat allergen (Fel d 1) on sensitization and asthma in adults. A total of 485 adults answered a questionnaire and had skin prick tests and lung function tests. Dust and air samples were collected from their bedrooms. The dust was analyzed for Der p 1, Fel d 1, and fungal biomass (ergosterol). Fungal propagules were measured in air samples. Current asthma was defined as having wheezed during the past 12 mo plus bronchial hyperreactivity (BHR) to methacholine. High exposure to total airborne fungi was associated with increased BHR, but perhaps paradoxically with a lower risk of being sensitized to fungi. Ergosterol levels in floor dust were a risk factor both for being sensitized to fungi and having wheezed within the last year. High Fel d 1 levels in floor dust were found to increase the risk of being sensitized to cats and in beds to increase the risk of current asthma. Although Der p 1 levels in homes were high, people exposed to high Der p 1 levels in floor dust were less likely to be sensitized to house dust mites or to have wheezed within the past year. Current indoor levels of fungi and Fel d 1, but not Der p 1, influenced sensitization and asthma in adults with high dust mite exposure.
authors: Department of Epidemiology and Preventive Medicine, Monash Medical School and The Alfred Hospital, Prahran, Melbourne, Australia. s.dharmage@gpph.unimelb.edu.au
authors: S
authors: S
authors: Dharmage
authors: M
authors: M
authors: Bailey
authors: J
authors: J
authors: Raven
authors: T
authors: T
authors: Mitakakis
authors: A
authors: A
authors: Cheng
authors: D
authors: D
authors: Guest
authors: J
authors: J
authors: Rolland
authors: A
authors: A
authors: Forbes
authors: F
authors: F
authors: Thien
authors: M
authors: M
authors: Abramson
authors: E H
authors: EH
authors: Walters
mesh_terms: D000328:Adult; D016902:Air Pollution, Indoor / Q000009:adverse effects*; D000485:Allergens / Q000009:adverse effects* / Q000302:isolation & purification*; D000818:Animals; D001249:Asthma / Q000453:epidemiology / Q000209:etiology*; D002415:Cats; D004391:Dust; D004781:Environmental Exposure; D005260:Female; D005658:Fungi; D006801:Humans; D008297:Male; D008875:Middle Aged; D008925:Mites; D012307:Risk Factors; D011795:Surveys and Questionnaires; D014739:Victoria / Q000453:epidemiology
chemical_list: D000485:Allergens; D004391:Dust