[Fawn-Hooded Rat; an animal model of development of pulmonary hypertension].
The Fawn-Hooded Rat (FHR) spontaneously develops pulmonary hypertension (PH) at sea level, and an increased severity of this disease is observed upon exposure to mild hypoxia. A recent report suggested that lung hypoplasia with decreased alveolarization and altered vascular growth led by the decreased activity of endothelial nitric oxide synthase may contribute to the development of PH in the FHR. Exposure to mild hypoxia (P1O2 = 120 mmHg) leads to severe PH in FHR but not in Tester Moriyama rat, a strain that has a serotonin platelet storage-pool deficiency (PSPD) similar to that of the FHR. A serotonin PSPD does not appear to predispose FHR to PH. Endothelin-1 (ET-1) mRNA and peptide levels are increased in the hypertensive lungs of mildly hypoxic FHR. ET-1 may at least partly contribute to the development of PH in this strain.
Muramatsu
M
M
Department of Respiratory Medicine, Juntendo University School of Medicine.
D000818:Animals; D004268:DNA-Binding Proteins / Q000502:physiology; D004195:Disease Models, Animal; D019332:Endothelin-1 / Q000096:biosynthesis / Q000235:genetics; D006976:Hypertension, Pulmonary / Q000209:etiology* / Q000378:metabolism; D000860:Hypoxia / Q000150:complications; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins / Q000502:physiology; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D012701:Serotonin / Q000502:physiology; D014157:Transcription Factors
D004268:DNA-Binding Proteins; D019332:Endothelin-1; C497444:Hif1a protein, rat; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D009687:Nuclear Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; D012701:Serotonin