Chest wall hamartoma with Wiedemann-Beckwith syndrome: clinical report and brief review of chromosome 11p15.5-related tumors.
A girl born with a left chest wall hamartoma, macroglossia, nevus flammeus of the middle forehead, and a small umbilical hernia developed left lower extremity hemihypertrophy by 1 year of age and is assumed to have Wiedemann-Beckwith syndrome. Hamartoma of the bladder and a cardiac fibrous hamartoma have been reported previously in association with Wiedemann-Beckwith syndrome. Infantile hamartomas are exceedingly rare and add to the spectrum of tumor formation in the syndrome.
Jonas
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RE
Department of Pediatrics, Southern Illinois University School of Medicine, Springfield, Illinois 62794-9230, USA.
Kimonis
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VE
D000293:Adolescent; D001506:Beckwith-Wiedemann Syndrome / Q000150:complications / Q000235:genetics / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics; D005260:Female; D006222:Hamartoma / Q000150:complications / Q000235:genetics / Q000473:pathology*; D006801:Humans; D007223:Infant; D008297:Male; D009369:Neoplasms / Q000235:genetics; D013896:Thoracic Diseases / Q000150:complications / Q000235:genetics / Q000473:pathology*