title: A putative GDP-GTP exchange factor is required for development of the excretory cell in Caenorhabditis elegans.
abstract: The Caenorhabditis elegans excretory cell extends tubular processes, called canals, along the basolateral surface of the epidermis. Mutations in the exc-5 gene cause tubulocystic defects in this canal. Ultrastructural analysis suggests that exc-5 is required for the proper placement of cytoskeletal elements at the apical epithelial surface. exc-5 encodes a protein homologous to guanine nucleotide exchange factors and contains motif architecture similar to that of FGD1, which is responsible for faciogenital dysplasia. exc-5 interacts genetically with mig-2, which encodes Rho GTPase. These results suggest that EXC-5 controls the structural organization of the excretory canal by regulating Rho family GTPase activities.
authors: Department of Molecular Biology, Graduate school of Science, Nagoya University and CREST, Japan.
authors: N
authors: N
authors: Suzuki
authors: M
authors: M
authors: Buechner
authors: K
authors: K
authors: Nishiwaki
authors: D H
authors: DH
authors: Hall
authors: H
authors: H
authors: Nakanishi
authors: Y
authors: Y
authors: Takai
authors: N
authors: N
authors: Hisamoto
authors: K
authors: K
authors: Matsumoto
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D030801:Animals, Genetically Modified; D017173:Caenorhabditis elegans / Q000737:chemistry / Q000196:embryology* / Q000648:ultrastructure; D029742:Caenorhabditis elegans Proteins; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000378:metabolism; D005091:Exons; D020662:Guanine Nucleotide Exchange Factors / Q000235:genetics* / Q000502:physiology*; D015801:Helminth Proteins / Q000235:genetics* / Q000502:physiology*; D007438:Introns; D008854:Microscopy, Electron; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009154:Mutation; D010957:Plasmids / Q000378:metabolism; D011485:Protein Binding
chemical_list: D029742:Caenorhabditis elegans Proteins; D018076:DNA, Complementary; D020662:Guanine Nucleotide Exchange Factors; D015801:Helminth Proteins; C434210:exc-5 protein, C elegans