Traceless solid-phase synthesis of substituted benzimidazoles via a base-cleavable linker.
[figure: see text] A solid-phase route to substituted benzimidazoles has been developed using a modified base-labile linker strategy to release the final products in a traceless manner. This approach permits the synthesis of diverse compounds in moderate yields and high purity.
Tumelty
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Affymax Research Institute, 4001 Miranda Avenue, Palo Alto, California 94304, USA. david_tumelty@affymax.com
Cao
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Holmes
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D000588:Amines / Q000737:chemistry; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000737:chemistry; D002384:Catalysis; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D000588:Amines; D001562:Benzimidazoles