[Current topics in vascular biology: an update for the 21st century].
Although taken for granted in the present day, the central role played by the blood vessels themselves in regulating the cardiovascular system under physiologic and pathologic conditions has only been understood in the last several decades. The field of vascular biology grew out of this appreciation of the primacy of the vasculature in cardiovascular pathologies. In this review, we come up to date on several topics of particular interest to the field of vascular biology as it enters the 21st century: namely, the role of oxidative stress in vascular function and dysfunction; angiogenesis and angiogenic gene therapies; and emerging biomarkers of atherosclerosis. Each of these areas is likely to experience significant advances in the coming years that will directly impact clinical decision-making and care of patients with cardiovascular diseases.
Patterson
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Department of Internal Medicine, and Lineberger Comprehensive Cancer Center. University of North Carolina at Chapel Hill. Chapel Hill. North Carolina. EE.UU. cpatters@med.unc.edu
D001808:Blood Vessels / Q000473:pathology / Q000502:physiology*; D002318:Cardiovascular Diseases / Q000473:pathology / Q000503:physiopathology; D002320:Cardiovascular Physiological Phenomena; D006801:Humans