Long-lasting myopathy as a major clinical feature of sarcoidosis in a child: case report with a 7-year follow-up.
Muscle involvement in sarcoidosis is rarely described as the predominant feature and muscular symptoms are seldom observed. In recent pediatric series, sarcoid myopathy was no longer considered a typical aspect of sarcoidosis. The authors report a case of sarcoidosis in a patient presenting predominant muscular symptoms since childhood, due to biopsy-proven muscle localization. A seven-year follow-up has demonstrated a slow improvement of symptoms with persistency of electromyography (EMG) and biochemical abnormalities. Mild and transient pulmonary involvement was demonstrated only after diagnosis. Clinical improvement associated with a decrease in serum muscular enzyme levels with no changes in EMG was observed after a six-month course of systemic corticosteroid therapy. In childhood, skeletal muscle symptoms may be the presenting feature of sarcoidosis.
Rossi
G A
GA
Unità Operativa di Pneumologia, Istituto G. Gaslini, L. go G. Gaslini 5, 16148 Genova, Italy. giovannirossi@ospedale-gaslini.ge.it
Battistini
E
E
Celle
M E
ME
Lamba
L D
LD
Pessagno
A
A
Gambini
C
C
Veneselli
E
E
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D002675:Child, Preschool; D004576:Electromyography; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology*; D009135:Muscular Diseases / Q000209:etiology* / Q000473:pathology; D011379:Prognosis; D012507:Sarcoidosis / Q000150:complications* / Q000473:pathology
D000305:Adrenal Cortex Hormones