[Autoimmune processes and biocompatibility in local damage of endothelium of the heart and its vessels].
At immunoproductive processes in endothelium of patients with coronary atherosclerosis and endocarditis a phase dynamics of innate immunity represented by polytypic Ca(2+)-dependent autoprecipitating proteins of nonclonal recognition of surface cell membrane components (CMC) have been revealed. In case of coronary atherosclerosis the organism reaction to expressed CMC is manifested basically by intensified synthesis of cathodic complement-C3-similar autoprecipitin, but in case of endocarditis--by consumption of one with formation of anodic autoprecipitin and by intensified synthesis of autoprecipitating immunoglobulin G. These membranotropic autoimmune reactions are identical with the organism reactions to alien (heterologous) agents and differentially participate in development both of basic disease and perioperational complications after cardiac operations using trans- and implants, hence, they should be taken into account during membrane-stabilising and immunocorrecting therapy of recipients.
Shevchenko
V S
VS
Institute of Cardiovascular Surgery of Academy of Medical Sciences of Ukraine.
D002462:Cell Membrane / Q000473:pathology; D003324:Coronary Artery Disease / Q000276:immunology* / Q000473:pathology*; D004566:Electrodes; D004730:Endothelium, Vascular / Q000276:immunology* / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D011234:Precipitins / Q000276:immunology*
D011234:Precipitins