Cancer chemopreventive agents. New depsidones from Garcinia plants.
In a search for cancer chemopreventive agents from natural sources, chemical constituents of two kinds of Garcinia plants, Garcinia neglecta and Garcinia puat, collected in New Caledonia, were examined. Five new depsidones, garcinisidone-B (2), -C (3), -D (4), -E (5), and -F (6), were isolated, and their structures were determined by spectrometric analyses. Inhibitory effects of these depsidones on EBV-EA activation induced by TPA in Raji cells were also demonstrated.
Ito
C
C
Faculty of Pharmacy, Meijo University, Tempaku, Nagoya 468-8503, Japan.
Itoigawa
M
M
Mishina
Y
Y
Tomiyasu
H
H
Litaudon
M
M
Cosson
J P
JP
Mukainaka
T
T
Tokuda
H
H
Nishino
H
H
Furukawa
H
H
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral / Q000378:metabolism; D053630:Depsides; D020448:Ericales / Q000737:chemistry*; D004988:Ethers, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004854:Herpesvirus 4, Human / Q000187:drug effects; D006801:Humans; D007783:Lactones; D008956:Models, Chemical; D009510:New Caledonia; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D016588:Anticarcinogenic Agents; D000956:Antigens, Viral; D053630:Depsides; C033305:Epstein-Barr virus early antigen; D004988:Ethers, Cyclic; D007783:Lactones; D010936:Plant Extracts; C000875:depsidone; D013755:Tetradecanoylphorbol Acetate