Severe toxic hepatitis associated with amoxycillin and clavulanic acid.
Toxic hepatitis secondary to amoxycillin-clavulanic acid is an infrequent clinical picture. Most of the cases are reported to have a benign course. We report two cases of severe hepatic failure following amoxycillin-clavulanic acid use. One of the cases had cholestatic features primarily, and the other had hepatocellular injury prominently. The first case had also findings of trombotic trombositic purpura and had a fatal course.
Ersoz
G
G
Department of Gastroenterology, Ege University Medical School, Bornova, 35100 Izmir, Turkey.
Karasu
Z
Z
Yildiz
C
C
Akarca
U S
US
Yuce
G
G
Batur
Y
Y
D000328:Adult; D000368:Aged; D019980:Amoxicillin-Potassium Clavulanate Combination / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D002779:Cholestasis / Q000139:chemically induced; D004359:Drug Therapy, Combination / Q000009:adverse effects*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007565:Jaundice / Q000139:chemically induced; D008297:Male
D019980:Amoxicillin-Potassium Clavulanate Combination