title: Effect of the universal base 3-nitropyrrole on the selectivity of neighboring natural bases.
abstract: [structure: see text] The effect of the universal base 3-nitropyrrole on the pairing selectivity of neighboring nucleosides has been determined for every combination of complementary and neighboring nucleosides. In a subset of cases the discriminatory ability of the neighboring nucleoside for its Watson-Crick complement is compromised. The results have implications for the hybridization of oligonucleotides that contain 3-nitropyrrole and suggest caution in the use of oligonucleotides that contain other universal bases.
authors: Department of Chemistry, Brown University, Providence, Rhode Island 02912, USA. john_oliver@brown.edu
authors: J S
authors: JS
authors: Oliver
authors: K A
authors: KA
authors: Parker
authors: J W
authors: JW
authors: Suggs
mesh_terms: D020137:Base Pair Mismatch; D020029:Base Pairing; D009841:Oligonucleotides / Q000737:chemistry*; D011758:Pyrroles / Q000737:chemistry*
chemical_list: D009841:Oligonucleotides; D011758:Pyrroles; C094911:3-nitropyrrole