title: Micronuclei and other nuclear lesions as genotoxicity indicators in rainbow trout Oncorhynchus mykiss.
abstract: The induction of micronuclei and other nuclear abnormalities in renal erythrocytes of rainbow trout Oncorhynchus mykiss by six genotoxic compounds is evaluated. Colchicine, mitomycin, cyclophosphamide, acrylamide, methyl-methanesulfonate, and N-ethyl-N-nitrosourea were intraperitoneally injected in trout. Our results show that cyclophosphamide induces the formation of micronuclei and also the other nuclear abnormalities; N-ethyl-N-nitrosourea, acrylamide, and colchicine induce only micronuclei; mitomycin-C induces only other nuclear abnormalities but not micronuclei. Methyl-methanesulfonate does not induce nuclear abnormalities in rainbow trout at the dose assayed in this work. The possible genotoxic origin for the different nuclear abnormalities is discussed.
authors: Departamento de Biologia Funcional, Area de Genetica, Facultad de Medicina, Universidad de Oviedo, c/Julian Claveria s/n, 33006 Oviedo, Spain. ayllon@sauron.quimica.uniovi.es
authors: F
authors: F
authors: Ayllón
authors: E
authors: E
authors: Garcia-Vazquez
mesh_terms: D020106:Acrylamide / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects*; D003078:Colchicine / Q000008:administration & dosage / Q000633:toxicity; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity; D004912:Erythrocytes / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008741:Methyl Methanesulfonate / Q000008:administration & dosage / Q000633:toxicity; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000633:toxicity; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects*; D015162:Micronucleus Tests; D016685:Mitomycin / Q000008:administration & dosage / Q000633:toxicity; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D017686:Oncorhynchus mykiss / Q000502:physiology
chemical_list: D009153:Mutagens; D020106:Acrylamide; D016685:Mitomycin; D008770:Methylnitrosourea; D003520:Cyclophosphamide; D008741:Methyl Methanesulfonate; D003078:Colchicine