Expression analysis of the histamine H(3) receptor in developing rat tissues.
Endogenous histamine is involved in tissue growth and cell proliferation. In accordance with a putative function of the H(3) receptor in this mitogenic effect, we show that H(3)-receptor mRNAs are expressed together with those of the histamine-synthesizing enzyme in the embryonic liver and adipose tissue, and in various epithelia. Finally, we show that activation of recombinant H(3) receptors enhances MAP kinase activity.
Héron
A
A
Laboratoire de Physiologie, Faculté des Sciences Pharmaceutiques et Biologiques, 4 avenue de l'Observatoire, 75006, Paris, France. anne.heron@pharmacie.univ-paris5.fr
Rouleau
A
A
Cochois
V
V
Pillot
C
C
Schwartz
J C
JC
Arrang
J M
JM
D000273:Adipose Tissue / Q000196:embryology; D000818:Animals; D000831:Animals, Newborn; D017403:In Situ Hybridization; D008024:Ligands; D008099:Liver / Q000196:embryology; D020935:MAP Kinase Signaling System; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011968:Receptors, Histamine / Q000378:metabolism; D018100:Receptors, Histamine H3 / Q000096:biosynthesis*; D011994:Recombinant Proteins / Q000378:metabolism
D008024:Ligands; D012333:RNA, Messenger; D011968:Receptors, Histamine; D018100:Receptors, Histamine H3; D011994:Recombinant Proteins