Low platelet count in a 22q11 deletion syndrome subtype of schizophrenia.
BACKGROUND
22q11 Deletion Syndrome (22qDS) is a genetic syndrome associated with various physical features and schizophrenia. Some reports have identified thrombocytopenia (platelet count < 150 x 10(9)/l) in individuals with 22qDS, especially children. We investigated whether adults with 22qDS and schizophrenia (22qDS-SZ) have lower platelet counts than other patients with schizophrenia (SZ).


METHODS
Complete blood counts (CBC) were recorded from medical records for 18 22qDS-SZ and 60 SZ subjects. Five CBCs per subject were randomly selected and used to calculate a within-subject mean for analyses.


RESULTS
22qDS-SZ subjects had significantly lower mean platelet counts than comparison SZ subjects (142.2 x 10(9)/l versus 282.5 x 10(9)/l, t = -11.5, p < 0.0001). Ten 22qDS-SZ (55%) and no comparison subjects had thrombocytopenia.


CONCLUSIONS
These results suggest that thrombocytopenia may be a common feature of 22qDS and that low platelet counts may comprise a readily available screening criterion to help identify this genetic syndrome among adults with schizophrenia.
Lazier
K
K
Schizophrenia Research Program, Queen Street Division, Centre for Addiction and Mental Health, Ontario, M6J 1H4, Toronto, Canada.
Chow
E W
EW
AbdelMalik
P
P
Scutt
L E
LE
Weksberg
R
R
Bassett
A S
AS
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D006801:Humans; D008297:Male; D010976:Platelet Count; D012559:Schizophrenia / Q000097:blood* / Q000235:genetics*; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000453:epidemiology