Mutations of the 3' untranslated region of the SDF1 gene in apes and monkeys: potential impact on sensitivity to AIDS induced by lentiviruses.
The comparison of the stromal cell-derived factor-1 (SDF1) gene 3' untranslated region (3'UTR) of four great ape and four monkey species with their human counterparts shows that the human SDF1-3'A mutation is present in primate species that are the most susceptible to lentivirus-induced AIDS and is absent in species that are particularly resistant to lentivirus-induced AIDS. The results enlighten the possible relationship between SDF1-3'UTR polymorphism and sensitivity to AIDS.
Puissant
B
B
Laboratoire d'Immunogénétique Moléculaire, Toulouse, France.
Blancher
A
A
D020413:3' Untranslated Regions; D000163:Acquired Immunodeficiency Syndrome / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D054377:Chemokine CXCL12; D019743:Chemokines, CXC / Q000235:genetics*; D004247:DNA; D017931:DNA Primers; D006801:Humans; D008969:Molecular Sequence Data; D009154:Mutation; D011323:Primates; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
D020413:3' Untranslated Regions; C515255:CXCL12 protein, human; D054377:Chemokine CXCL12; D019743:Chemokines, CXC; D017931:DNA Primers; D004247:DNA