Pathogenesis of influenza A (H5N1) virus infection in a primate model.
Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.
Rimmelzwaan
G F
GF
Institute of Virology, National Influenza Center, Erasmus University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands.
Kuiken
T
T
van Amerongen
G
G
Bestebroer
T M
TM
Fouchier
R A
RA
Osterhaus
A D
AD
D000818:Animals; D004195:Disease Models, Animal; D005334:Fever / Q000473:pathology; D007150:Immunohistochemistry; D053124:Influenza A Virus, H5N1 Subtype; D009980:Influenza A virus / Q000302:isolation & purification; D017563:Lung Diseases, Interstitial / Q000473:pathology / Q000821:virology; D008252:Macaca fascicularis; D009336:Necrosis; D009976:Orthomyxoviridae Infections / Q000821:virology*; D012128:Respiratory Distress Syndrome / Q000473:pathology; D014781:Viscera / Q000821:virology