Patients with Multiple Sclerosis and concomitant uveitis/periphlebitis retinae are not distinct from those without intraocular inflammation.
Recent models of experimental autoimmune encephalomyelitis (EAE) have indicated that antigens co-expressed in the retina and uvea might be of pathogenetic relevance in Multiple Sclerosis (MS). We investigated the clinical spectrum and magnetic resonance imaging of 11 MS patients with concomitant uveitis, and determined the frequency of clinically silent intraocular inflammation in a prospective series of 50 patients. Two of the 11 patients had panuveitis, seven had anterior, and the remaining two had intermediate uveitis. The onset of uveitis preceded that of neurological symptoms by a mean of 8.5 years (range 1-20). None of the 50 MS patients studied prospectively by using slit lamp examinations and dilated funduscopy showed any evidence of uveitis but six patients had signs of retinal inflammation ("periphlebitis retinae"). Cranial MRI did not reveal "atypical" lesional distribution in MS patients with uveitis or periphlebitis retinae. No correlation between the type of MS and uveitis, or between the degree of neurological disability and the type of uveitis was found.
Schmidt
S
S
Department of Neurology, University of Bonn, Sigmund-Freud-Str. 25, D-53105 Bonn, Germany. stephschm@aol.com
Wessels
L
L
Augustin
A
A
Klockgether
T
T
D000328:Adult; D002490:Central Nervous System / Q000276:immunology / Q000473:pathology / Q000503:physiopathology; D003941:Diagnostic Techniques, Ophthalmological; D004185:Disability Evaluation; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D010689:Phlebitis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D011446:Prospective Studies; D012189:Retrospective Studies; D014605:Uveitis / Q000150:complications* / Q000276:immunology / Q000473:pathology; D014792:Visual Acuity / Q000276:immunology