Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients.
Deficient orexin signaling has been shown to cause narcolepsy-like conditions in animals. In human narcolepsy, CSF levels of orexin A (hypocretin-1) were reported to be low in most cases. The authors measured CSF and plasma orexin A levels in patients with narcolepsy and in controls. Confirming earlier studies, they found CSF orexin A levels to be extremely low in patients with narcolepsy. However, plasma orexin A levels did not differ from those observed in controls. These results suggest that orexin deficiency in patients with narcolepsy is a phenomena restricted to the CNS.
Dalal
M A
MA
Max Planck Institute of Psychiatry, Munich, Germany.
Schuld
A
A
Haack
M
M
Uhr
M
M
Geisler
P
P
Eisensehr
I
I
Noachtar
S
S
Pollmächer
T
T
D000328:Adult; D002352:Carrier Proteins / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000097:blood* / Q000134:cerebrospinal fluid*; D009479:Neuropeptides / Q000097:blood* / Q000134:cerebrospinal fluid*; D000068797:Orexins; D011863:Radioimmunoassay
D002352:Carrier Proteins; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins