title: Subcutaneous extramedullary hematopoiesis in a patient with secondary myelofibrosis following polycythemia vera.
abstract: We describe the case of a 73-year-old woman with secondary myelofibrosis who developed subcutaneous extramedullary hematopoiesis. Although extramedullary hematopoiesis has been generally observed in primary myelofibrosis, in this case it was seen in myelofibrosis secondary to polycythemia vera. Histological examination of the subcutaneous nodule revealed that the lesion included cells from the myeloid and megakaryocytic series. The skin lesion almost disappeared after treatment with hydroxyurea. We report here this rare manifestation in secondary myelofibrosis including a review of literature.
authors: First Department of Internal Medicine, Yokohama City University School of Medicine, Yokohama, Japan.
authors: M
authors: M
authors: Tanaka
authors: H
authors: H
authors: Kanamori
authors: S
authors: S
authors: Yamaji
authors: A
authors: A
authors: Mishima
authors: E
authors: E
authors: Yamazaki
authors: J
authors: J
authors: Taguchi
authors: M
authors: M
authors: Aoba
authors: S
authors: S
authors: Fujisawa
authors: H
authors: H
authors: Mohri
authors: Y
authors: Y
authors: Ishigatsubo
mesh_terms: D000368:Aged; D005260:Female; D006411:Hematopoiesis, Extramedullary; D006801:Humans; D006918:Hydroxyurea / Q000008:administration & dosage; D008533:Megakaryocytes / Q000473:pathology; D022423:Myeloid Cells / Q000473:pathology; D011087:Polycythemia Vera / Q000150:complications*; D055728:Primary Myelofibrosis / Q000150:complications* / Q000209:etiology; D012871:Skin Diseases / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology
chemical_list: D006918:Hydroxyurea