Potential roles of antisense technology in cancer chemotherapy.
Antisense technology may play a major role in cancer chemotherapy. It is clearly a tool of exceptional value in the functionalization of genes and their validation as potential targets for cancer chemotherapy. Additionally, there is now substantial evidence that antisense drugs are safe, and a growing body of data showing activity in animal models of human disease including cancer, and suggesting efficacy in patients with cancer. In this article, I review the progress in the technology, the anticancer antisense drugs in development and potential roles that antisense technology might play.
Crooke
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Isis Pharmaceuticals, Inc, Carlsbad, California 92008, USA.
D000970:Antineoplastic Agents / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D015195:Drug Design; D006801:Humans; D008957:Models, Genetic; D009369:Neoplasms / Q000188:drug therapy*; D020319:Oligodeoxyribonucleotides, Antisense / Q000493:pharmacokinetics / Q000494:pharmacology / Q000627:therapeutic use*; D012334:RNA, Neoplasm / Q000187:drug effects*
D000970:Antineoplastic Agents; D020319:Oligodeoxyribonucleotides, Antisense; D012334:RNA, Neoplasm