A novel and selective approach to enantiomerically pure bicyclic-trans-lactams via a titanium enolate of a thiopyridyl ester.
Cooke
J W
JW
Glaxo Wellcome Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire SG1 2NY, U.K. jwbc16317@glaxowellcome.co.uk
Berry
M B
MB
Caine
D M
DM
Cardwell
K S
KS
Cook
J S
JS
Hodgson
A
A
D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry; D006801:Humans; D019272:Leukocyte Elastase / Q000037:antagonists & inhibitors*; D009682:Magnetic Resonance Spectroscopy; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry*
D004791:Enzyme Inhibitors; C119405:GW 311616; D010880:Piperidines; D019272:Leukocyte Elastase