An exploratory approach to the serotonergic hypothesis of depression: bridging the synaptic gap.
In this exploratory review, we attempt to integrate pre and post synaptic theories of the biochemical basis of depression--in particular with regard to 5-HT. We will be providing evidence that in major depressive disorder, there is a continuity of dysfunction of neural function, i.e. pre and post synaptic serotonergic symptoms are affected. Furthermore, we will also be providing the implications of this approach for normal treatments for depressive disorder.
Dursun
S M
SM
Psychopharmacology Unit, Department of Psychiatry, Dalhousie University, Queen Elizabeth II Health Sciences Centre, Abbie J. Lane Building, 4th Floor Suite 4083, Halifax, Nova Scotia B3H 2E2, Canada. sdursun@is.dal.ca
Blackburn
J R
JR
Kutcher
S P
SP
D000928:Antidepressive Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003863:Depression / Q000188:drug therapy / Q000503:physiopathology*; D006801:Humans; D007294:Inositol / Q000502:physiology / Q000627:therapeutic use; D015290:Second Messenger Systems; D012701:Serotonin / Q000502:physiology*; D013569:Synapses / Q000502:physiology*
D000928:Antidepressive Agents; D012701:Serotonin; D007294:Inositol