title: Chemical constituents from Lippia sidoides and cytotoxic activity.
abstract: Eleven known compounds and a new prenylated naphthoquinone, lippsidoquinone (13), were isolated from ethanol extracts of Lippia sidoides. Their structures were established by a combination of 1D and 2D NMR, IR, and EIMS spectral data analysis. The cytotoxic properties of compounds 3--13 were evaluated against HL60, SW1573, and CEM cell lines. Only tectol (6) and lippsidoquinone (13) exhibited significant activity against human leukemia cell lines HL60 and CEM.
authors: Departamento de Química Orgânica e Inorgânica, Universidade Vale do Acaraú, CP 12200 60451-970 Fortaleza, Ceará, Brazil.
authors: S M
authors: SM
authors: Costa
authors: T L
authors: TL
authors: Lemos
authors: O D
authors: OD
authors: Pessoa
authors: C
authors: C
authors: Pessoa
authors: R C
authors: RC
authors: Montenegro
authors: R
authors: R
authors: Braz-Filho
mesh_terms: D000330:Aedes; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D001700:Biomphalaria; D001938:Brazil; D004354:Drug Screening Assays, Antitumor; D007306:Insecticides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008975:Molluscacides / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D009285:Naphthoquinones / Q000737:chemistry* / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007306:Insecticides; D008975:Molluscacides; D009285:Naphthoquinones; C433560:lippsidoquinone