title: Correlation between clinical atypia and histologic dysplasia in acquired melanocytic nevi.
abstract: BACKGROUND
  The validity of clinical and histologic criteria in identifying dysplastic nevi is controversial. Recognition of the dysplastic nevus as a distinct clinicopathologic entity requires demonstration of significant agreement between clinical atypia and histologic dysplasia.
  
  
  OBJECTIVE
  We attempted to determine the correlation between clinical atypia and histologic dysplasia in acquired melanocytic nevi and to evaluate the sensitivity and specificity of clinical criteria for dysplastic nevi when compared with histopathologic features.
  
  
  METHODS
  A total of 940 acquired melanocytic nevi 3 mm in diameter or larger were selected by initially choosing clinically unequivocal dysplastic and nondysplastic nevi and then, from these, histologically unequivocal dysplastic and nondysplastic lesions. The level of concordance between clinical atypia and histologic dysplasia was estimated by kappa statistics.
  
  
  RESULTS
  Nevi were classified as clinically dysplastic (n = 499) or nondysplastic (n = 441). On the basis of histologic features, 739 were classified as dysplastic and 201 as nondysplastic. Agreement between clinical atypia and histologic dysplasia was found in 432 nevi, that is, a sensitivity of 58.4% (3-5 mm = 27.2%, >5 mm = 69.8%). Agreement between clinical and histologic criteria on the absence of dysplasia was found in 134 nevi, a specificity of 66.6% (3-5 mm = 92.4%, >5 mm = 47.9%). The kappa value was 0.17 (3-5 mm = 0.14, >5 mm = 0.10).
  
  
  CONCLUSIONS
  The limited sensitivity and specificity together with the negligible kappa value indicate a poor agreement between clinical and histologic diagnoses of dysplastic nevus. The dysplastic nevus cannot be considered a distinct clinicopathologic entity because histologic dysplasia is found in a range of nevi that may or may not show clinical atypia.
authors: Department of Dermatology, the Laboratory of Dermatopathology, Istituto Dermopatico dell'Immacolata IRCCS, Rome, Italy.
authors: G
authors: G
authors: Annessi
authors: M S
authors: MS
authors: Cattaruzza
authors: D
authors: D
authors: Abeni
authors: G
authors: G
authors: Baliva
authors: M
authors: M
authors: Laurenza
authors: V
authors: V
authors: Macchini
authors: F
authors: F
authors: Melchi
authors: P
authors: P
authors: Ruatti
authors: P
authors: P
authors: Puddu
authors: T
authors: T
authors: Faraggiana
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009508:Nevus, Pigmented / Q000145:classification / Q000175:diagnosis / Q000473:pathology*; D015588:Observer Variation; D010808:Physical Examination; D012680:Sensitivity and Specificity