Preliminary report: Amino acid profile in platelets of diabetic patients.
Platelet levels of 19 amino acids were measured in 20 outpatients with type 1 (age [mean +/- SE], 35.5 +/- 2.0 years) and 27 with type 2 (age, 58.4 +/- 1.4 years) diabetes, and 20 young (age 33.7 +/- 1.3 years) and 20 older (age 57.4 +/- 1.5 years) healthy volunteers. Platelet levels of most amino acids tended to be lower in patients with type 1 diabetes than in healthy controls. In particular, asparagine, glycine, taurine, alanine, valine, cysteine, leucine, phenylalanine, and lysine levels, expressed as nmol/10(8) platelets, were significantly lower. Only taurine significantly decreased in patients with type 2 diabetes, whereas threonine, alanine, and isoleucine increased.
De Luca
G
G
Institute of Biochemical Sciences and Clinical Biochemistry and the Department of Internal Medicine, School of Medicine, University of Messina, Messina, Italy.
Calpona
P R
PR
Caponetti
A
A
Macaione
V
V
Di Benedetto
A
A
Cucinotta
D
D
Di Giorgio
R M
RM
D000328:Adult; D000596:Amino Acids / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged
D000596:Amino Acids