Clostridium perfringens beta toxin and Clostridium septicum alpha toxin: their mechanisms and possible role in pathogenesis.
The Clostridium septicum alpha toxin and the Clostridium perfringens beta toxin are examples of pore-forming toxins that exhibit several different features. The cell types that are targeted by these toxins reflect the effect these toxins have on the host during infection with either organism. Alpha toxin elicits a rapid shock-like syndrome, whereas beta toxin appears to induce a variety of neurological effects. The effects of the purified toxins appear to mimic some of the features of the animal and human diseases caused by C. septicum and C. perfringens. This review, examines the current state of knowledge for the cytolytic mechanism, role in pathogenesis and structure of these two toxins.
Tweten
R K
RK
Department of Microbiology and Immunology, University of Oklahoma Health Science Center, P.O. Box 26901, Oklahoma City 73190, OK, USA. rod-tweten@ouhsc.edu
D001427:Bacterial Toxins / Q000737:chemistry / Q000494:pharmacology*; D003013:Clostridium / Q000472:pathogenicity*; D003015:Clostridium Infections / Q000382:microbiology / Q000503:physiopathology; D003016:Clostridium perfringens / Q000472:pathogenicity
D001427:Bacterial Toxins; C031884:CPB protein, Clostridium perfringens; C064270:hemolytic toxin, Clostridium septicum