title: The nigrostriatal dopaminergic system in familial early onset parkinsonism with parkin mutations.
abstract: Nigrostriatal dopaminergic function and cerebral energy metabolism were measured with PET in two brothers with early-onset parkinsonism caused by mutation of the parkin gene. Energy metabolism did not differ, but the nigrostriatal dopaminergic pattern was clearly different than that of sporadic PD. Thus parkinsonism in these two patients was shown to be pathophysiologically different than PD.
authors: Movement Disorder Unit, Department of Neurology, University Hospital, Groningen, the Netherlands.
authors: A T
authors: AT
authors: Portman
authors: N
authors: N
authors: Giladi
authors: K L
authors: KL
authors: Leenders
authors: P
authors: P
authors: Maguire
authors: L
authors: L
authors: Veenma-van der Duin
authors: J
authors: J
authors: Swart
authors: J
authors: J
authors: Pruim
authors: E S
authors: ES
authors: Simon
authors: S
authors: S
authors: Hassin-Baer
authors: A D
authors: AD
authors: Korczyn
mesh_terms: D017668:Age of Onset; D001921:Brain / Q000000981:diagnostic imaging; D003342:Corpus Striatum / Q000000981:diagnostic imaging*; D006801:Humans; D008025:Ligases / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009154:Mutation / Q000235:genetics*; D020734:Parkinsonian Disorders / Q000000981:diagnostic imaging / Q000235:genetics*; D013378:Substantia Nigra / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed; D044767:Ubiquitin-Protein Ligases
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases