[The effect of long-term administration of isosorbide 5-mononitrate (Mononit), nitric oxide donor, on gallbladder emptying in patients with chronic stable angina].
In 13 patients (7 females and 6 males) with newly found, previously not treated, chronic stable angina the interprandial volume of the gallbladder and its emptying after treatment with isosorbide-5-mononitrate (Mononit) were examined. The volume of gallbladder was estimated with ultrasonography first after administration of 10 or 20 mg of Mononit twice a day and then in 3rd and 6th week of treatment. It was found that the intake of the single dose as well as the long treatment with Mononit had no effect on interprandial volume of gallbladder. However the intake of drug led to the significant inhibition of postprandial gallbladder's contractility both after the single dose and long term treatment with Mononit.
Hamankiewicz
M
M
Oddziału Wewnetrznego B Zespołu Opieki Zdrowotnej w Bedzinie.
Kucio
C
C
Czapla
J
J
Wójcik
P
P
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D002908:Chronic Disease; D004334:Drug Administration Schedule; D005260:Female; D005704:Gallbladder / Q000000981:diagnostic imaging; D016473:Gallbladder Emptying / Q000187:drug effects*; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000009:adverse effects* / Q000031:analogs & derivatives; D008297:Male; D008875:Middle Aged; D020030:Nitric Oxide Donors / Q000008:administration & dosage*; D014463:Ultrasonography
D020030:Nitric Oxide Donors; D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate