title: Successful outcome of pregnancy in a patient with generalized lipoatrophic diabetes mellitus.
abstract: OBJECTIVE
  To report the first known case of a successful outcome of pregnancy in a patient with generalized lipoatrophic diabetes.
  
  
  METHODS
  We present a detailed case report of a patient who achieved and successfully completed a pregnancy despite having lipoatrophic diabetes.
  
  
  RESULTS
  With careful attention to glycemic control with use of U-500 insulin and strict avoidance of dietary fat, a 23-year-old woman with lipoatrophic diabetes maintained a pregnancy to 28 weeks. The infant weighed 1,235 g and was devoid of serious metabolic complications. Three months after childbirth, the patient died of gastrointestinal bleeding.
  
  
  CONCLUSIONS
  We are not aware of any previously published report of a successful pregnancy in a patient with generalized, acquired lipoatrophic diabetes. Because of the involvement of multiple organ systems in generalized lipoatrophic diabetes, female patients should be thoroughly advised of the serious pregnancy-associated risks to both the mother and the fetus and the need for extremely close monitoring.
authors: Department of Medicine, Riddle Memorial Hospital, Media, Pennsylvania, USA.
authors: B K
authors: BK
authors: Dolberg
authors: M J
authors: MJ
authors: Lenhard
mesh_terms: D000328:Adult; D003923:Diabetes Mellitus, Lipoatrophic / Q000178:diet therapy* / Q000188:drug therapy*; D018752:Diet, Fat-Restricted; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000178:diet therapy* / Q000188:drug therapy*; D011256:Pregnancy Outcome
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin