Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate.
The efficacies of diloxanide furoate, beta-cyclodextrin and a cyclodextrin inclusion complex against Cryptosporidium parvum were evaluated in a suckling murine model. Efficacy was established by numbers of oocysts recovered from the intestinal tract of mice on day 7 postinfection. The level of infection in treated mice was significantly lower than in control mice and, surprisingly, the most efficacious treatment was beta-cyclodextrin, an excipient used in pharmaceutical technology.
Castro Hermida
J A
JA
Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Santiago de Compostela, La Coruña, Spain.
Ares-Mazás
M E
ME
Nieto Reyes
L
L
Otero Espinar
F
F
Blanco Méndez
J
J
D000563:Amebicides / Q000627:therapeutic use*; D000818:Animals; D002417:Cattle; D003457:Cryptosporidiosis / Q000188:drug therapy* / Q000469:parasitology; D016785:Cryptosporidium parvum / Q000302:isolation & purification* / Q000502:physiology; D003505:Cyclodextrins / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004337:Drug Carriers; D004359:Drug Therapy, Combination; D005079:Excipients; D005663:Furans / Q000627:therapeutic use*; D051379:Mice; D010270:Parasite Egg Count; D047392:beta-Cyclodextrins
D000563:Amebicides; D003505:Cyclodextrins; D004337:Drug Carriers; D005079:Excipients; D005663:Furans; D047392:beta-Cyclodextrins; C031215:betadex; C004932:diloxanide furoate