title: Markedly raised serum prostate specific antigen levels. Prostatic infarction rather than malignancy?
abstract: BACKGROUND
  Though prostate specific antigen (PSA) and prostate acid phosphatase (PAP) are of greater value in the postoperative monitoring of patients with cancer of the prostate, high preoperative levels suggest the probability of malignancy. Benign conditions of the prostate are known to raise the serum levels of these enzymes, however, the higher the level of these markers the stronger is the suspicion of malignancy.
  
  
  OBJECTIVE
  This report describes five patients who presented with acute urinary retention and had evidence of prostatic infarction and chronic prostatitis on histology.
  
  
  CONCLUSIONS
  The combination of these factors probably accounted for the extremely elevated levels of PSA and PAP as other possible causes were ruled out.
authors: Princess Margaret Hospital, Swindon, United Kingdom.
authors: P R
authors: PR
authors: Kiran
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D003937:Diagnosis, Differential; D006801:Humans; D007238:Infarction / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000098:blood supply* / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000032:analysis / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis*; D012680:Sensitivity and Specificity
chemical_list: D014408:Biomarkers, Tumor; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen