Effect of titanium exposure on embryonic development during pre-implantation period in rats.
Doses of titanium trichloride (1/10th and 1/5th of LD50) were administered once and daily to pregnant rats to assess their effect on embryonic development. 1/5th dose of TiCl3 administered once orally on 1st, 2nd and 3rd day post-coitum. Similarly 1/10th of LD50 was administered daily. Results revealed that 1/10th LD50 dose of TiCl3 was more effective during pre-implantation period as number of 4 and 8-celled embryos decreased as compared to 1/5th. Delayed hatching of the blastocysts on day 5 was registered in TiCl3 treated dam.
Malik
B
B
Laboratory of Contraceptive Research and Reproductive Health, School of Studies in Zoology, Jiwaji University, Gwalior 474 011, India.
Prakash
A O
AO
Rai
M
M
D000818:Animals; D001755:Blastocyst / Q000166:cytology / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D007928:Lethal Dose 50; D011247:Pregnancy; D051381:Rats; D014025:Titanium / Q000008:administration & dosage / Q000633:toxicity*
D014025:Titanium; C039460:titanium trichloride