Genetic diversity at the FMR1 locus in the Indonesian population.
We report an analysis of allelic diversity at short tandem repeat polymorphisms within the fragile XA locus in 1069 male volunteers from twelve Indonesian sub-populations. An odd numbered allele of DXS548 was found at high frequency in all Indonesian populations. Greater allelic diversity was identified at the loci under study than has been previously reported for an Asian population. These differences distinguish the Indonesian population from all previously reported Asian, European and African populations. A high frequency of small premutation alleles, 4/120 (3.3%, 95% CI 0.9-8.3%), was identified in the Moluccan population of Hiri Island.
Faradz
S M
SM
Molecular and Cytogenetics Unit, South Eatern Area Laboratory Services, Sydney, Australia.
Pattiiha
M Z
MZ
Leigh
D A
DA
Jenkins
M
M
Leggo
J
J
Buckley
M F
MF
Holden
J J
JJ
D000483:Alleles; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D005006:Ethnicity / Q000235:genetics; D051860:Fragile X Messenger Ribonucleoprotein 1; D014644:Genetic Variation; D005828:Genetics, Population; D006239:Haplotypes; D006801:Humans; D007214:Indonesia; D015810:Linkage Disequilibrium; D008297:Male; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016601:RNA-Binding Proteins; D018911:Trinucleotide Repeats; D014960:X Chromosome / Q000235:genetics
D017931:DNA Primers; D051860:Fragile X Messenger Ribonucleoprotein 1; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; C497683:FMR1 protein, human