A new strategy for cancer therapy based on a predictive indicator.
Tumor-associated genes have been analyzed at the molecular level in recent years, and using the analyses of these genes as a predictive indicator for cancer therapy has attracted attention. Among such genes, the actions of a tumor suppressor gene p53 are focused on the cancer therapy, and it is suggested that p53 genotypes can be used as a predictive indicator for radiotherapy, thermotherapy and chemotherapy. Transfection of wtp53 to p53-null cells increased radiation- or thermo-sensitivity and stimulated apoptosis induced by these therapies. Although therapy-induced apoptosis is suppressed in mp53 cells, apoptosis can be stimulated by glycerol treatment as a chemical chaperone. Therefore, a new strategy of combining p53-targeted gene therapy or chemical chaperone therapies is expected to improve the outcome and efficiency of cancer therapy in the future.
Kirita
T
T
Department of Oral and Maxillofacial Surgery, Nara Medical University.
Ohnishi
K
K
Ohnishi
T
T
D017209:Apoptosis / Q000187:drug effects; D005544:Forecasting; D016158:Genes, p53 / Q000235:genetics; D015316:Genetic Therapy; D005838:Genotype; D005990:Glycerol / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D018832:Molecular Chaperones / Q000627:therapeutic use; D009154:Mutation; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D014162:Transfection; D016896:Treatment Outcome
D018832:Molecular Chaperones; D005990:Glycerol