Uridine 5'-diphosphoglucuronic acid (UDPGLcUA) in the human fetal liver, kidney and placenta.
The endogenous concentration of uridine 5'-diphosphoglucoronic acid (UDPGLcUA), the endogenus substrate of UDP-glucuronosyltransferase, was measured in the human fetal and adult liver and kidney and in the placenta. The concentrations (mumol/Kg wet weight) of UDPGLcUA were 59.4 +/- 11.3 (fetal liver), 301 +/- 119 (adult liver), 11.9 +/- 3.2 (fetal kidney), 17.4 +/- 3.0 (adult kidney), 17.8 +/- 1.8 (mid-term placenta) and 17.0 +/- 1.7 (term placenta). UDPGLcUA is present in the human fetal liver at a concentration 5-fold lower than in the adult liver indicating a potential limiting factor for glucuronidation ind the human fetus.
Cappiello
M
M
Department of Biomedicine, Medical School, University of Pisa, Pisa, Italy.
Giuliani
L
L
Rane
A
A
Pacifici
G M
GM
D000328:Adult; D000368:Aged; D005260:Female; D005333:Fetus / Q000737:chemistry*; D014453:Glucuronosyltransferase / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000737:chemistry*; D008099:Liver / Q000737:chemistry*; D008297:Male; D008875:Middle Aged; D010920:Placenta / Q000737:chemistry*; D011247:Pregnancy; D014535:Uridine Diphosphate Glucuronic Acid / Q000032:analysis*
D014535:Uridine Diphosphate Glucuronic Acid; D014453:Glucuronosyltransferase