title: Ectopic ACTH syndrome caused by pulmonary carcinoid tumourlets.
abstract: The differential diagnosis of Cushing's syndrome is a major challenge to clinical endocrinologists, especially those infrequent cases referred to as occult ectopic ACTH syndromes. Although bronchial carcinoids are well known to be a cause of Cushing's syndrome due to ectopic ACTH secretion, very few cases of carcinoid tumourlets causing an ACTH ectopic syndrome have been reported, and their origin remains controversial. For some authors, tumourlets and typical carcinoids represent distinct pathological entities, whilst others hold that tumourlets are merely microscopic carcinoid tumours. We report a patient with an aggressive Cushing's syndrome that required bilateral adrenalectomy, diagnosed 22 years before a 3-cm lung nodule became apparent on routine chest X-ray. The biopsy after lung surgery revealed a typical peripheral bronchial carcinoid surrounded by tumourlets. Both tumourlets and carcinoid tumour showed strongly positive ACTH immunostaining. Recently, Arioglu et al. (1998) reported a case of Cushing's syndrome caused by pulmonary carcinoid tumourlets, concluding that this entity should be considered in the differential diagnosis of occult ectopic ACTH syndrome. Furthermore, we consider that the carcinoid tumourlets found in our patient, were the initial source of ACTH, leading to Cushing's syndrome with a rapid onset, and that a loss of cell proliferation control in one of such tumourlets many years later, could have resulted in the development of a typical carcinoid tumour, reinforcing the theory of a common origin of these lesions.
authors: Section of Endocrinology and Clinical Nutrition, Department of Internal Medicine, Hospital Universitario 'Reina Sofía', Córdoba, Spain.
authors: S T
authors: ST
authors: Povedano
authors: C V
authors: CV
authors: Pastor
authors: C P
authors: CP
authors: Seoane
authors: L J
authors: LJ
authors: Reina
authors: M A
authors: MA
authors: Moreno
authors: R P
authors: RP
authors: Ortega
authors: F
authors: F
authors: López-Rubio
authors: P B
authors: PB
authors: López
mesh_terms: D000182:ACTH Syndrome, Ectopic / Q000209:etiology* / Q000473:pathology / Q000601:surgery; D000315:Adrenalectomy; D000328:Adult; D001984:Bronchial Neoplasms / Q000150:complications* / Q000473:pathology / Q000601:surgery; D002276:Carcinoid Tumor / Q000150:complications* / Q000473:pathology / Q000601:surgery; D003480:Cushing Syndrome / Q000150:complications / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male