Comparative analysis of the promoter structure and genomic organization of the human and mouse ABCA7 gene encoding a novel ABCA transporter.
We report here the genomic and transcriptional characterization in mouse and man of a novel transporter of the ABCA subclass, named ABCA7. As it is the case for other ABCA genes, the predicted protein encoded by ABCA7 is a full symmetric transporter, highly conserved across species. The ABCA7 gene maps to human chromosome 19 and to the homologous region at band B4-C1 on mouse chromosome 10. The preferential expression of ABCA7 in the spleen, thymus, and fetal liver is consistent with the finding, in both human and mouse promoter, of sites targeted by lymphomyeloid-specific transcription factors. This suggests that ABCA7 may play a pivotal role in the developmental specification of hematopoietic cell lineages.
Broccardo
C
C
Centre d'Immunologie INSERM-CNRS de Marseille Luminy, Marseille, France.
Osorio
J
J
Luciani
M F
MF
Schriml
L M
LM
Prades
C
C
Shulenin
S
S
Arnould
I
I
Naudin
L
L
Lafargue
C
C
Rosier
M
M
Jordan
B
B
Mattei
M G
MG
Dean
M
M
Denèfle
P
P
Chimini
G
G
D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D002460:Cell Line; D002888:Chromosomes, Human, Pair 19 / Q000235:genetics; D017124:Conserved Sequence / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns / Q000235:genetics*; D008099:Liver / Q000196:embryology / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D009928:Organ Specificity; D011401:Promoter Regions, Genetic / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D021101:Radiation Hybrid Mapping; D016415:Sequence Alignment; D012689:Sequence Homology, Nucleic Acid; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism
C411895:ABCA7 protein, human; D018528:ATP-Binding Cassette Transporters; C485856:Abca7 protein, mouse; D018076:DNA, Complementary; D012333:RNA, Messenger