Spatial performance correlates with long-term potentiation of the dentate gyrus but not of the CA1 region in rats with fimbria-fornix lesions.
Although hippocampal long-term potentiation (LTP) is generally assumed to be a cellular mechanism of learning and memory, there has not been definitive evidence for this hypothesis. In the present study, therefore, we addressed the possible relationship between spatial learning ability and LTP by using rats with bilateral fimbria-fornix lesions. The animals were tested for spatial performance in spontaneous alternation behaviors with further in vivo investigation of LTP. The behavioral parameters of spatial memory showed a significant correlation with LTP in the dentate gyrus, but we found no evidence for a linkage with LTP in the CA1 region. Thus, LTP in the dentate gyrus may be important for spatial cognitive ability.
Nakao
K
K
Laboratory of Chemical Pharmacology, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 113-0033, Tokyo, Japan.
Ikegaya
Y
Y
Yamada
M K
MK
Nishiyama
N
N
Matsuki
N
N
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D018891:Dentate Gyrus / Q000166:cytology / Q000502:physiology*; D004558:Electric Stimulation; D019706:Excitatory Postsynaptic Potentials / Q000502:physiology; D020712:Fornix, Brain / Q000166:cytology / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D009949:Orientation / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013028:Space Perception / Q000502:physiology*