title: Prevalence and significance of unrecognized lower extremity peripheral arterial disease in general medicine practice*.
abstract: OBJECTIVE
  To determine the prevalence of unrecognized lower extremity peripheral arterial disease (PAD) among men and women aged 55 years and older in a general internal medicine (GIM) practice and to identify characteristics and functional performance associated with unrecognized PAD.
  
  
  METHODS
  Cross-sectional.
  
  
  METHODS
  Academic medical center.
  
  
  METHODS
  We identified 143 patients with known PAD from the noninvasive vascular laboratory, and 239 men and women aged 55 and older with no prior PAD history from a GIM practice. Group 1 consisted of patients with PAD consecutively identified from the noninvasive vascular laboratory (n = 143). Group 2 included GIM practice patients found to have an ankle brachial index less than 0.90, consistent with PAD (n = 34). Group 3 consisted of GIM practice patients without PAD (n = 205).
  
  
  RESULTS
  Leg functioning was assessed with the 6-minute walk, 4-meter walking velocity, and Walking Impairment Questionnaire (WIQ). Of GIM practice patients, 14% had unrecognized PAD. Only 44% of patients in Group 2 had exertional leg symptoms. Distances achieved in the 6-minute walk were 1,130, 1,362, and 1,539 feet for Groups 1, 2, and 3, respectively, adjusting for age, gender, and race (P <.001). The degree of difficulty walking due to leg symptoms as reported on the WIQ was comparable between Groups 2 and 3 and significantly greater in Group 1 than Group 2. In multiple logistic regression analysis including Groups 2 and 3, current cigarette smoking was associated independently with unrecognized PAD (odds ratio [OR], 6.82; 95% confidence interval [95% CI], 1.55 to 29.93). Aspirin therapy was nearly independently associated with absence of PAD (OR, 0.37; 95% CI, 0.12 to 1.12).
  
  
  CONCLUSIONS
  Unrecognized PAD is common among men and women aged 55 years and older in GIM practice and is associated with impaired lower extremity functioning. Ankle brachial index screening may be necessary to diagnose unrecognized PAD in a GIM practice.
authors: Department of Medicine, Northwestern University Medical School, Chicago, IL, USA. mdm608@nwu.edu
authors: M M
authors: MM
authors: McDermott
authors: D R
authors: DR
authors: Kerwin
authors: K
authors: K
authors: Liu
authors: G J
authors: GJ
authors: Martin
authors: E
authors: E
authors: O'Brien
authors: H
authors: H
authors: Kaplan
authors: P
authors: P
authors: Greenland
mesh_terms: D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply* / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016491:Peripheral Vascular Diseases / Q000503:physiopathology*; D015995:Prevalence; D012044:Regression Analysis