Pentalenolactone I and hygromycin A, immunosuppressants produced by Streptomyces filipinensis and Streptomyces hygroscopicus.
Immunosuppressants isolated from Streptomyces filipinensis and S. hygroscopicus were identified with pentalenolactone I and hygromycin A, respectively. The compounds as well as cyclosporin A showed immunosuppressant activity in the mixed lymphocyte reaction, and pentalenolactone I and cyclosporin A suppressed IL-2 production, however, hygromycin A did not. Hygromycin A may have immunosuppressant activity by a different mechanism from pentalenolactone I, cyclosporin A and tacrolimus.
Uyeda
M
M
Faculty of Pharmaceutical Sciences, Kumamoto University, Japan. uyeda@gpo.kumamoto-u.ac.jp
Mizukami
M
M
Yokomizo
K
K
Suzuki
K
K
D002934:Cinnamates; D016572:Cyclosporine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006921:Hygromycin B / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D007166:Immunosuppressive Agents / Q000302:isolation & purification* / Q000494:pharmacology; D007376:Interleukin-2 / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D011753:Pyrones / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D013045:Species Specificity; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*; D016559:Tacrolimus / Q000494:pharmacology
D002934:Cinnamates; D007166:Immunosuppressive Agents; D007376:Interleukin-2; D011753:Pyrones; C438912:pentalenolactone I; D006921:Hygromycin B; C026273:hygromycin A; D016572:Cyclosporine; D016559:Tacrolimus