title: A variant of the endotheliotropic herpesvirus in Asian elephants (Elephas maximus) in European zoos.
abstract: Newly discovered, lethal elephant endotheliotropic herpesviruses (EEHV) have been identified in both Asian (Elephas maximus) and African (Loxodonta africana) elephants. Carried by otherwise healthy African elephants they can be fatal mainly for young Asian elephants. Since zoos often harbour both elephant species, we conducted a survey on the presence of EEHV in Asian elephants from 12 European zoos, 3 circuses and 1 Israeli zoo. Here, we demonstrate that all EEHV that have affected Asian elephants so far belong to the EEHV1 group. We also describe the detection and the partial sequencing of an endotheliotropic herpesvirus variant (named EEHV1b) in Asian elephants, being either an EEHV endogenous to Asian elephants or indicating different sources (African elephants) of infection.
authors: Institute for Zoo Biology and Wildlife Research, Alfred-Kowalke-Strasse 17, D-10315, Berlin, Germany. fickel@izw-berlin.de
authors: J
authors: J
authors: Fickel
authors: L K
authors: LK
authors: Richman
authors: R
authors: R
authors: Montali
authors: W
authors: W
authors: Schaftenaar
authors: F
authors: F
authors: Göritz
authors: T B
authors: TB
authors: Hildebrandt
authors: C
authors: C
authors: Pitra
mesh_terms: D015075:2-Aminopurine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000595:Amino Acid Sequence; D000818:Animals; D000836:Animals, Zoo; D000998:Antiviral Agents / Q000627:therapeutic use; D001483:Base Sequence; D004279:DNA, Viral / Q000032:analysis*; D004606:Elephants; D005060:Europe / Q000453:epidemiology; D000077595:Famciclovir; D005814:Genes, Viral; D006564:Herpesviridae / Q000145:classification / Q000235:genetics*; D006566:Herpesviridae Infections / Q000188:drug therapy / Q000453:epidemiology / Q000662:veterinary*; D007181:Inclusion Bodies, Viral; D007557:Israel / Q000453:epidemiology; D010802:Phylogeny; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015995:Prevalence
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D015075:2-Aminopurine; D000077595:Famciclovir