Epstein-Barr virus-associated peripheral T-cell lymphoma in adults with hydroa vacciniforme-like lesions.
We describe two Korean adult patients who had necrotizing papulovesicles mainly on their faces. Skin biopsy specimens showed perivascular and periadnexal infiltrate of atypical lymphoid cells with vasculitis in the dermis and subcutaneous tissue. In situ hybridization demonstrated a latent infection of Epstein-Barr virus in the majority of lymphoid cells in the dermis. These patients were diagnosed as having T-cell lymphoma. Interestingly, large granular lymphocytosis was found in the peripheral blood of Case 2.
Cho
K H
KH
Department of Dermatology, Seoul National University College of Medicine, Seoul, Korea. khcho@snu.ac.kr
Kim
C W
CW
Heo
D S
DS
Lee
D S
DS
Choi
W W
WW
Rim
J H
JH
Han
W S
WS
D000328:Adult; D020031:Epstein-Barr Virus Infections / Q000150:complications*; D005148:Facial Dermatoses / Q000821:virology*; D005260:Female; D015334:Gene Rearrangement, gamma-Chain T-Cell Antigen Receptor; D006801:Humans; D006837:Hydroa Vacciniforme / Q000821:virology*; D016411:Lymphoma, T-Cell, Peripheral / Q000821:virology*; D008297:Male; D017193:Skin Diseases, Viral / Q000821:virology*