title: Value of 99mTc-MIBI scintimammography in women with impalpable breast lesions seen on mammography.
abstract: OBJECTIVE
  To find out if 99mTc-methoxyisobutylisonitrile scintimammography (MIBI) is useful in the evaluation of impalpable breast lesions in women referred for biopsy after mammography screening.
  
  
  METHODS
  Observational and prospective study.
  
  
  METHODS
  Radiological screening campaign in Spain.
  
  
  METHODS
  36 patients referred between September 1997 and June 1998 (37 biopsies) with impalpable breast lesions referred consecutively from a screening campaign. Ages ranged from 50 to 64 years.
  
  
  METHODS
  Mammography, ultrasound, MIBI, and wire-guided biopsy.
  
  
  RESULTS
  Mean values for sensitivity, specificity, positive predictive value, and negative predictive value for scintimammography were 78.9, 72.2, 75, and 76.5 respectively (p = 0.002). The logistic regression analysis showed that 99mTc-MIBI scintimammography result predicted (p = 0.003) the risk of breast cancer in this group of patients (odds ratio: 9.75), particularly infiltrating ductal carcinoma.
  
  
  CONCLUSIONS
  MIBI scintimammography in patients referred for biopsy after mammography screening does not so much rule out cancer as confirm the diagnosis. Its practical benefit would be not so much avoiding biopsy for these patients as aiding in planning the radicality of their excision.
authors: Department of General Surgery, University Hospital J Ma Morales Meseguer, Murcia, Spain. jaguilar@santandersupernet.com
authors: J
authors: J
authors: Aguilar
authors: B
authors: B
authors: Andrés
authors: F
authors: F
authors: Nicolás
authors: M
authors: M
authors: Muelas
authors: D
authors: D
authors: Pérez-Flores
authors: J L
authors: JL
authors: Aguayo
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
chemical_list: D019275:Radiopharmaceuticals; D017256:Technetium Tc 99m Sestamibi