title: Do oral flora colonize the nasal floor of patients with oronasal fistulae?
abstract: OBJECTIVE
  To determine if oral bacteria colonize the cleft nasal floor in patients with unilateral oronasal fistula when compared with the unaffected nasal floor and whether the results obtained would be of benefit in assessing oronasal fistulae in the clinic.
  
  
  METHODS
  Prospective study of 26 patients with cleft palate and unilateral oronasal fistula. Microbiological culture swabs were taken from the mouth and nasal floors of patients. The unaffected nasal floor was used as a control. Bacterial isolates were identified and compared in the laboratory by a senior microbiologist.
  
  
  METHODS
  A significant growth of oral bacteria from the cleft nasal floor when compared with the unaffected nasal floor.
  
  
  RESULTS
  Four patients were excluded because no growth was found on any culture plate. In the remaining 22 cases, a light growth of oral flora was found in the cleft nasal floor in only 3 patients. No statistical correlation between culture of oral bacteria and the cleft nasal floor could be found (p =.12).
  
  
  CONCLUSIONS
  The relative lack of colonization of the cleft nasal floor by oral bacteria may reflect poor transmission of bacteria through the fistula, competition with commensal nasal flora, or an inability of oral bacteria to survive in a saliva-depleted area. The investigation is not helpful in the assessment of oronasal fistulae in the clinic.
authors: Oral and Maxillofacial Surgery, Queen Alexandra Hospital, Portsmouth, England, UK. brennandocs@btinternet.com
authors: P A
authors: PA
authors: Brennan
authors: A F
authors: AF
authors: Markus
authors: T R
authors: TR
authors: Flood
authors: I P
authors: IP
authors: Downie
authors: R
authors: R
authors: Uppal
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005402:Fistula / Q000382:microbiology*; D006801:Humans; D007223:Infant; D009055:Mouth / Q000382:microbiology*; D009666:Nose / Q000382:microbiology*; D009668:Nose Diseases / Q000382:microbiology*; D016155:Oral Fistula / Q000382:microbiology*; D011446:Prospective Studies