Meiotic recombination: breaking the genome to save it.
Recombination ensures the correct segregation of chromosomes to gametes during meiosis. Recent studies point to a universal mechanism for initiating meiotic recombination: the formation of double-strand DNA breaks by Spo11p.
Lichten
M
M
Laboratory of Biochemistry, National Cancer Institute, Building 37 Room 6124, Bethesda, Maryland 20892-4255, USA. lichten@helix.nih
D000818:Animals; D017360:Arabidopsis / Q000166:cytology / Q000235:genetics; D002843:Chromatin / Q000502:physiology; D020090:Chromosome Segregation / Q000235:genetics; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004706:Endodeoxyribonucleases; D004950:Esterases / Q000235:genetics / Q000378:metabolism; D008540:Meiosis / Q000235:genetics / Q000502:physiology; D051379:Mice; D008957:Models, Genetic; D009154:Mutation; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism; D000099257:Meiotic Recombination Protein SPO11
D002843:Chromatin; D004247:DNA; D004706:Endodeoxyribonucleases; D004950:Esterases; D000099257:Meiotic Recombination Protein SPO11