Motoric behavior in aged rats treated with GM1.
Aging is associated with impaired motor function. Nigrostriatal dopaminergic neurons, in part, regulate motoric behavior, and undergo degenerative changes during aging. GM1 ganglioside partially restores pre-synaptic dopaminergic markers and the number and morphology of dopaminergic neurons in the midbrain and striatum of Sprague--Dawley aged rats. These studies investigated whether GM1 treatment, 30 mg/kg, i.p. daily for 36 days, affects locomotor and stereotypic activity, as well as coordination, balance, and strength in aged rats. Under the treatment conditions used, GM1 did not improve the reduced locomotor and stereotypic behavior of the aged rats. While it partially improved performance on a square bridge test, GM1 had no effect on inclined screen and rod suspension tests. Although GM1 restored the decreased content of dopamine and homovanillic acid in the nigrostriatal neurons of the aged rats, it had no effect on the reduced D1 and D2 dopamine receptor binding and mRNA in the striatum. It appears, that despite the morphological and metabolic restoration of aged nigrostriatal neurons, GM1 has limited ability in improving age-associated motor deficits.
Goettl
V M
VM
Department of Pharmacology, The Ohio State University College of Medicine and Public Health, Columbus, OH 43210, USA.
Wemlinger
T A
TA
Colvin
A E
AE
Neff
N H
NH
Hadjiconstantinou
M
M
D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D005677:G(M1) Ganglioside / Q000378:metabolism / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009069:Movement Disorders / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D009434:Neural Pathways / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000187:drug effects / Q000378:metabolism; D013378:Substantia Nigra / Q000187:drug effects / Q000378:metabolism*
D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D005677:G(M1) Ganglioside; D004298:Dopamine; D006719:Homovanillic Acid