[Evaluation of clinical effectiveness of intravenous laser irradiation of blood, plasmapheresis and their combination in patients with bronchial asthma].
OBJECTIVE
To compare clinical response to intravenous laser radiation of blood (ILRB), plasmapheresis (PA) and ILRB + PA in patients with bronchial asthma (BA).


METHODS
122 patients with endogenic BA of moderate severity were divided into four groups: group 1 was exposed to ILRB, group 2--to PA, group 3--to ILRB + PA, group 4 received only chemotherapy. The effect was assessed by body plethismography, peak flowmetry, NBT-test, LCP-test.


RESULTS
Patients of group 1-3 vs group 4 demonstrated earlier disappearance of cough and normalization of lung auscultative picture, lower demand of oral glucocorticosteroids, 2 times longer remission, better external respiration function, earlier normalization of peak expiration flow. ILRB, PA and ILRB + PA activate function of oxygen-dependent bactericidal system of blood neutrophils and inhibited activity of non-oxygen-dependent system.


CONCLUSIONS
Combined treatment of moderate severity BA with ILRB, PA alone and in combination is more effective than conventional drug therapy, the highest effect by remission terms being achieved in combination of ILRB with PA.
Ishina
T I
TI
Kakhnovskiĭ
I M
IM
Makarova
O V
OV
Solomatin
A S
AS
Alekseeva
M E
ME
D000328:Adult; D001249:Asthma / Q000628:therapy*; D001769:Blood / Q000528:radiation effects*; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007834:Lasers; D008297:Male; D010956:Plasmapheresis; D010991:Plethysmography; D013997:Time Factors