Synthesis and growth inhibitory properties of glucosamine-derived glycerolipids.
[figure: see text] 2-Amino C-glycerolipid 1b was synthesized by using the Ramberg-Bäcklund rearrangement as the key step. beta-C-Glycerolipid 1b exhibits in vitro antiproliferative effects strikingly similar to those of O-glycoside analogue 1a.
Yang
G
G
Department of Chemistry, Hunter College/CUNY, 695 Park Avenue, New York, New York 10021, USA.
Franck
R W
RW
Bittman
R
R
Samadder
P
P
Arthur
G
G
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects*; D005260:Female; D005944:Glucosamine; D006017:Glycolipids / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity*; D006801:Humans; D008297:Male; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006017:Glycolipids; D005944:Glucosamine