Comparative study of ceftriaxone versus cefazolin plus clindamycin as antibiotic prophylaxis in elective colorectal surgery.
A comparative study of 103 consecutive patients who required antibiotic prophylaxis for elective colorectal surgery was carried out. All eligible patients received either ceftriaxone (2 g) as a single intravenous dose at anesthetic induction or cefazolin (1 g) plus clindamycin (0.6g) administered intravenously at anesthetic induction and for two more doses at 8-hourly intervals for a total of 3 days. The incidence of postoperative wound infections was 6.9% in the ceftriaxone group and 11.1% in the cefazolin plus clindamycin group. Single-dose ceftriaxone proved to be a safe and cost-effective form of antibiotic prophylaxis for elective colorectal surgery.
Mecchia
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General Surgical Unit, S. Vito al Tagliamento Civic Hospital, Pordenone, Italy. a.infantino@si-it.com
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000714:Anastomosis, Surgical; D019072:Antibiotic Prophylaxis; D002437:Cefazolin / Q000008:administration & dosage / Q000627:therapeutic use*; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D003108:Colonic Diseases / Q000601:surgery*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome
D002981:Clindamycin; D002443:Ceftriaxone; D002437:Cefazolin