Short-term effects of radiotherapy on attention and memory performances in patients with brain tumors.
BACKGROUND
The objective of the current study was to evaluate the short-term effects of radiotherapy on attention and memory performance in patients with brain tumors.


METHODS
Thirteen patients underwent a neuropsychologic examination on three occasions: at baseline before radiotherapy, which lasted for 6 weeks; within 2 weeks after the completion of radiotherapy; and 3 months after the completion of radiotherapy. Thirty healthy individuals were studied at baseline as a control group. Verbal, visuomotor, and memory tests were administered. Attentional performances were examined using CogniSpeed reaction time software.


RESULTS
At baseline, the patients scored significantly lower than the controls in tests of semantic memory (Similarities; P = 0.002), visuoconstructive skill (Block Design; P = 0.028), and visual and verbal memory (recall of 20 objects: immediate, P = 0.017; delayed, P = 0.002; recall of 30 paired word associates: immediate, P = 0.002; delayed, P = 0.005). The patients performed significantly more poorly than the control group on the Two-Choice Reaction Time test (P = 0.047), the Subtraction test (P = 0.042), and the Vigilance test (P = 0.023). After radiotherapy, the performance of the patients did not worsen on any measure, whereas their conscious cognitive processing was improved (P = 0.002).


CONCLUSIONS
Treatment with radiotherapy did not cause negative short-term effects on attentional and memory functions in patients with brain tumors who received a radiation dose of 54.5 grays. The cognitive deficits found in these patients were evident at baseline before radiotherapy. Thus, it seems likely that the deficits were associated with the tumor itself and/or the surgical procedures.
Lilja
A M
AM
Department of Psychology, University of Turku, Turku, Finland. arja.lilja@ms-liitto.it
Portin
R I
RI
Hämäläinen
P I
PI
Salminen
E K
EK
D000328:Adult; D001288:Attention / Q000528:radiation effects*; D001932:Brain Neoplasms / Q000523:psychology* / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008568:Memory / Q000528:radiation effects*; D011581:Psychological Tests; D011597:Psychomotor Performance; D011878:Radiotherapy / Q000009:adverse effects