Impact of Cu(II) and Ni(II) on a structure of chiral peptide nucleic acids having four, six and eight thymines in a peptide side chain.
The studies on binding ability of longer chiral peptide nucleic acids (having four, six and eight thymines in a peptide side chain) have shown that the interactions between the nucleic base rings within a ligand molecule have a critical impact on the complex stability. Thymines inserted in the peptide side chain interact with each other as well as with peptide back-bone increasing the structural organization of the cPNA molecule. The metal ion coordination to cPNA, on the other hand, induces a very specific ligand structure, which may have a basic impact on the cPNA self-recognition processes.
Brasun
J
J
Department of Basic Medical Sciences, Medical University, Kochanowskiego 14, 51-601, Wrocław, Poland.
Oldziej
S
S
Taddei
M
M
Kozłowski
H
H
D003300:Copper / Q000378:metabolism / Q000494:pharmacology*; D004355:Drug Stability; D008958:Models, Molecular; D015394:Molecular Structure; D009532:Nickel / Q000378:metabolism / Q000494:pharmacology*; D020135:Peptide Nucleic Acids / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary / Q000187:drug effects; D013237:Stereoisomerism; D013941:Thymine / Q000378:metabolism*
D020135:Peptide Nucleic Acids; D003300:Copper; D009532:Nickel; D013941:Thymine