Regression of lymph node metastases by immunotherapy using autologous breast tumor-lysate pulsed dendritic cells: report of a case.
A 50-year-old woman was diagnosed as having stage IV breast cancer with bilateral supraclavicular lymph node metastasis resistant to CAF therapy. She received immunotherapy using autologous tumor lysate-pulsed dendritic cells (DCs). Four cycles of DC injection into the right supraclavicular lymph nodes resulted in regression of bilateral supraclavicular lymphogenous metastasis. Histological studies revealed an accumulation of CD45+ T lymphcytes in the regressive lymph nodes. This case suggests that immunotherapy with DCs may be a safe and promising approach for the treatment of advanced breast cancer.
Kobayashi
T
T
Department of General and Gastroenterological Surgery, Osaka Medical College, Takatsuki, Japan.
Shinohara
H
H
Toyoda
M
M
Iwamoto
S
S
Tanigawa
N
N
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm / Q000008:administration & dosage / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000473:pathology / Q000628:therapy*; D003713:Dendritic Cells; D005260:Female; D006433:Hemocyanins; D006801:Humans; D008207:Lymphatic Metastasis; D008875:Middle Aged; D012074:Remission Induction
D000276:Adjuvants, Immunologic; D000951:Antigens, Neoplasm; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin