title: Crohn disease: susceptibility and disease heterogeneity revealed by HLA genotyping.
abstract: Predisposition to Crohn disease (CD) seems to be genetically determined but, though several reports on the matter, the association between HLA antigens and the disease is still controversial. PCR-SSP high resolution typing in 107 CD patients, and in subgroups selected according to clinical features, showed a positive association with the rare haplotype DRB1*07, DQB1*0303 both in the overall patients (p = 0.002; pc = ns) and in the subgroup of nonfistulized patients (p = 0.0008; pc = 0.032). Moreover, the protective role of the haplotype DRB1*03, DQB1*0201 (p = 0.029) was confirmed also in Italian patients, whereas no strong association with HLA class I alleles has been found. In addition, variability of the HLA alleles frequency in CD subgroups was observed, supporting the hypothesis of a genetic heterogeneity of the disease and suggesting that HLA alleles distribution in selected groups may allow to identify patients with probably different prognosis or associated complications.
authors: Centro Trasfusionale AORN A. Cardarelli, Napoli, Italy. mllombardi@yahoo.com
authors: M L
authors: ML
authors: Lombardi
authors: G
authors: G
authors: Pirozzi
authors: V
authors: V
authors: Luongo
authors: O
authors: O
authors: Mercuro
authors: E
authors: E
authors: Pace
authors: G
authors: G
authors: Blanco Del Vecchio
authors: A
authors: A
authors: Cozzolino
authors: S
authors: S
authors: Errico
authors: C
authors: C
authors: Fusco
authors: F
authors: F
authors: Castiglione
mesh_terms: D000483:Alleles; D003424:Crohn Disease / Q000235:genetics* / Q000276:immunology*; D017931:DNA Primers; D005787:Gene Frequency; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006650:Histocompatibility Testing; D006801:Humans; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000276:immunology
chemical_list: D017931:DNA Primers