title: Risk of uterine rupture during labor among women with a prior cesarean delivery.
abstract: BACKGROUND
  Each year in the United States, approximately 60 percent of women with a prior cesarean delivery who become pregnant again attempt labor. Concern persists that a trial of labor may increase the risk of uterine rupture, an uncommon but serious obstetrical complication.
  
  
  METHODS
  We conducted a population-based, retrospective cohort analysis using data from all primiparous women who gave birth to live singleton infants by cesarean section in civilian hospitals in Washington State from 1987 through 1996 and who delivered a second singleton child during the same period (a total of 20,095 women). We assessed the risk of uterine rupture for deliveries with spontaneous onset of labor, those with labor induced by prostaglandins, and those in which labor was induced by other means; these three groups of deliveries were compared with repeated cesarean delivery without labor.
  
  
  RESULTS
  Uterine rupture occurred at a rate of 1.6 per 1000 among women with repeated cesarean delivery without labor (11 women), 5.2 per 1000 among women with spontaneous onset of labor (56 women), 7.7 per 1000 among women whose labor was induced without prostaglandins (15 women), and 24.5 per 1000 among women with prostaglandin-induced labor (9 women). As compared with the risk in women with repeated cesarean delivery without labor, uterine rupture was more likely among women with spontaneous onset of labor (relative risk, 3.3; 95 percent confidence interval, 1.8 to 6.0), induction of labor without prostaglandins (relative risk, 4.9; 95 percent confidence interval, 2.4 to 9.7), and induction with prostaglandins (relative risk, 15.6; 95 percent confidence interval, 8.1 to 30.0).
  
  
  CONCLUSIONS
  For women with one prior cesarean delivery, the risk of uterine rupture is higher among those whose labor is induced than among those with repeated cesarean delivery without labor. Labor induced with a prostaglandin confers the highest risk.
authors: Center for Women's Health Research, Department of Family and Child Nursing, School of Nursing, University of Washington, Seattle 98195-7262, USA. minot@u.washington.edu
authors: M
authors: M
authors: Lydon-Rochelle
authors: V L
authors: VL
authors: Holt
authors: T R
authors: TR
authors: Easterling
authors: D P
authors: DP
authors: Martin
mesh_terms: D000293:Adolescent; D000328:Adult; D015331:Cohort Studies; D005260:Female; D006801:Humans; D015994:Incidence; D007751:Labor, Induced / Q000009:adverse effects*; D007743:Labor, Obstetric; D011247:Pregnancy; D011248:Pregnancy Complications; D011453:Prostaglandins / Q000009:adverse effects; D012189:Retrospective Studies; D012306:Risk; D014597:Uterine Rupture / Q000453:epidemiology / Q000209:etiology*; D016064:Vaginal Birth after Cesarean / Q000009:adverse effects*; D014861:Washington
chemical_list: D011453:Prostaglandins