Histological diversity of vasculitic lesions in MPO-ANCA-positive autopsy cases.
To investigate the variety of histological features of vasculitic lesions in myeloperoxidase-specific antineutrophil cytoplasmic antibody (pANCA)-related vasculitis, retrospective pathological analysis was done on 13 autopsy cases, collected from 1990 to 1998 at five hospitals. These cases were classified into three groups: (i) pulmonary-renal syndrome characterized by capillaritis of lung and glomeruli with occasional small-vessel arteritis and/or phlebitis; (ii) glomerular capillaritis without pulmonary involvement associated with significant small-vessel arteritis; and (iii) extensive distribution of small-vessel arteritis with no capillary involvement. The results suggest that pANCA-related vasculitis encompasses a wide variety of vasculitic syndromes, including pulmonary-renal syndrome, microscopic polyarteritis nodosa, and classic polyarteritis nodosa. pANCA may contribute to pathogenesis in all of these cases.
Sano
K
K
Department of Laboratory Medicine, Shinsu University School of Medicine, Matsumoto, Japan. kenjisa@sch.md.shinshu-u.ac.jp
Sakaguchi
N
N
Ito
M
M
Koyama
M
M
Kobayashi
M
M
Hotchi
M
M
D000368:Aged; D000369:Aged, 80 and over; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000378:metabolism / Q000473:pathology; D006470:Hemorrhage / Q000150:complications / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008171:Lung Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009195:Peroxidase / Q000276:immunology; D010488:Polyarteritis Nodosa / Q000276:immunology / Q000473:pathology; D011650:Pulmonary Alveoli / Q000276:immunology / Q000473:pathology; D013577:Syndrome; D014657:Vasculitis / Q000097:blood / Q000276:immunology / Q000473:pathology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D009195:Peroxidase