The effects of flumazenil on sleepiness, task performance and nocturnal sleep after anesthesia with midazolam.
The purpose of the present study was to clarify the changes in psychophysiological functions after anesthesia with midazolam (intravenous (i.v.) benzodiazepine anesthetic) and to examine the ability of flumazenil (benzodiazepine antagonist) to prevent the adverse effects of anesthesia with midazolam. Clinical dose of midazolam (0.1 mg/kg i.v.) was administered to seven healthy volunteers and either flumazenil (0.3 mg i.v.) or saline was injected at the end of the anesthesia. After anesthesia with midazolam, subjective sleepiness and euphoria increased significantly, but these changes were not observed when flumazenil was administered. In addition, sleep latency was prolonged and sleep efficiency decreased significantly after midazolam anesthesia with and without flumazenil. Slow wave sleep decreased significantly only by co-administration of flumazenil.
Ozone
M
M
Department of Psychiatry, The Jikei University School of Medicine, The Jikei Nursing School, Japan. ozone-m@246.ne.jp
Itoh
H
H
Ohbuchi
K
K
Ohyama
E
E
Hayashida
K
K
Sato
M
M
Sasaki
M
M
Ushijima
S
S
Tanifuji
Y
Y
D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D006970:Disorders of Excessive Somnolence / Q000139:chemically induced* / Q000517:prevention & control*; D005442:Flumazenil / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D018757:GABA Modulators / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008874:Midazolam / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D017286:Polysomnography / Q000379:methods; D012894:Sleep Stages / Q000187:drug effects*
D018686:Anesthetics, Intravenous; D018757:GABA Modulators; D005442:Flumazenil; D008874:Midazolam