title: Functionalized bicyclo[3.3.0]octanes by enantioselective transannular desymmetrization.
abstract: [figure: see text] Enantioselective alpha-deprotonation-rearrangement of achiral substituted cyclooctene oxides 7, 17, and 18 using organolithiums in the presence of (-)-sparteine (3) or (-)-alpha-isosparteine (4) gives the functionalized bicyclo[3.3.0]octan-2-ols 8, 19, and 20 in 56-72% yields and 83-89% ee's.
authors: Dyson Perrins Laboratory, Department of Chemistry, University of Oxford, South Parks Road, Oxford, U.K. OX1 3QY. david.hodgson@chem.ox.ac.uk
authors: D M
authors: DM
authors: Hodgson
authors: I D
authors: ID
authors: Cameron