A polymer-supported proline-based diamine catalyst for the kinetic resolution of racemic secondary alcohols.
The preparation of polymer-supported proline-based diamine catalyst 12 for the kinetic resolution of racemic mixtures of secondary alcohols is described. Not only is the catalyst effective for the resolution of a host of different alcohols, it can also be recovered and reused several times without loss of either activity or selectivity. The catalyst has been used in conjunction with a polymer-supported sequestration strategy, giving rise to an essentially pure mixture of resolved products that can be separated using flash chromatography.
Clapham
B
B
Department of Chemistry, Scripps Research Institute and, Skaggs Institute for Chemical Biology, 10550 North Torrey Pines Road, La Jolla, California 92037, USA.
Cho
C W
CW
Janda
K D
KD
D000438:Alcohols / Q000737:chemistry*; D002384:Catalysis; D003959:Diamines / Q000737:chemistry*; D007700:Kinetics; D011392:Proline / Q000737:chemistry*; D013057:Spectrum Analysis
D000438:Alcohols; D003959:Diamines; D011392:Proline