[Inferring genotype of DNA molecular marker by Bayesian theorem].
Bayesian theorem is applied to infer DNA molecular marker genotype (DNA chain type) from its phenotype (electrophoresis band type). The results indicate that large difference often presents in the genotype probability of a molecular marker with incomplete genetic information when it is obtained from the assumption of independence among markers as compared with that inferred from the genotypes of the flanking markers with the complete genetic information and the recombination fractions among them based on the Bayesian theorem. Therefore, before utilizing the marker information, such as in mapping quantitative trait loci (QTL), marker assisted selection (MAS) etc., Bayes' probability of the genotype for all markers with incomplete genetic information must be calculated over the whole genome for every individual. This study provided detailed procedure for the calculation of the Bayes' probability of the unknown DNA genotype. Several extensions were also discussed for the application of the Bayesian theorem in genetics.
Mo
H D
HD
Laboratory of Quantitative Genetics, Yangzhou University, Yangzhou 225009, China.
Jiang
C J
CJ
D001499:Bayes Theorem; D005819:Genetic Markers; D005838:Genotype
D005819:Genetic Markers