A rapid procedure for initial drug evaluation.
The overall aim of this work is to develop computer simulations to aid in the selection of proposed medicines and identify those most likely to succeed. One important feature is a systems approach to simulate both the target area with which the drug is designed to interact as well as the surrounding areas where feedback mechanisms may alter the expected effect. The simulation must be rapid if it is to be used to evaluate large numbers of potential drugs. Thus the procedure simplifies many of the known complex phenomena to provide a general framework and feedback mechanisms. An example of the use of the simulation to study a drug used to treat hypertension is given. A possible use of the technique is shown using the example of the effect of varying the drug dosage on the contraction of the arteriole muscle.
Macpherson
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AK
Institute for Biomedical Engineering and Mathematical Biology, Lehigh University, Bethlehem, PA 18015, USA. macpherson@lehigh.edu
Neti
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Macpherson
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D017311:Amlodipine / Q000494:pharmacology; D000959:Antihypertensive Agents / Q000494:pharmacology; D001160:Arterioles / Q000187:drug effects; D015220:Calcium Channels / Q000378:metabolism; D003198:Computer Simulation; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation / Q000379:methods*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007477:Ions; D008962:Models, Theoretical; D009119:Muscle Contraction / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D012984:Software
D000959:Antihypertensive Agents; D015220:Calcium Channels; D007477:Ions; D017311:Amlodipine; D012964:Sodium