Dendritic structure of single hippocampal neurons according to sex and hemisphere of origin in middle-aged and elderly human subjects.
The organization of basilar dendritic patterns in the CA1 hippocampal region obtained from 13 middle-aged and elderly human subjects was assessed using the Golgi method. Neurons were classified according to hemisphere of origin and the sex of the respective subjects. Three parameters were measured: total dendritic length (TDL), number of dendritic segments (NDS) and average segment length (ASL, which is TDL divided by NDS). Dendritic segments were classified into proximal (first to third order) and distal (fourth order and above). Sex differences were found in distal TDL and in proximal and distal NDS, neurons belonging to males having larger values than those belonging to females. In addition, a hemispheric difference was detected in distal TDL, in which neurons of the left hemisphere had larger values than those of the right hemisphere.
Barrera A
Programa de Morfología, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 1027 Independencia Avenue, P.O. Box 70079, Santiago 7, Chile.
Jiménez
L
L
González
G M
GM
Montiel
J
J
Aboitiz
F
F
D000368:Aged; D000375:Aging / Q000473:pathology*; D048429:Cell Size / Q000502:physiology*; D003627:Data Interpretation, Statistical; D003712:Dendrites / Q000502:physiology / Q000648:ultrastructure*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000166:cytology* / Q000502:physiology; D006801:Humans; D008297:Male; D008568:Memory / Q000502:physiology; D008569:Memory Disorders / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D017966:Pyramidal Cells / Q000166:cytology* / Q000502:physiology; D015203:Reproducibility of Results; D012727:Sex Characteristics; D016622:Silver Staining; D018709:Statistics, Nonparametric