[Clinical effectiveness of superoxide inhalations and their effects on crystalline structure and antiradical defense of blood serum and expired air condensate in patients with bronchial asthma].
OBJECTIVE
To raise efficiency of combined treatment of bronchial asthma (BA) by application of intranasal inhalations of gaseous superoxide (GSO) basing on clinicolaboratory, functional and biochemical indices.


METHODS
The study entered 20 healthy subjects and 57 BA patients. All of the patients received conventional treatment, but 30 of them additionally inhaled GSO. The effect of inhalations was assessed by parameters of LPO products, enzymatic and nonenzymatic antiradical defense (ARD) in the blood and expired air condensate (EAC), morphometry of EAC crystalline structures.


RESULTS
GSO intranasal inhalations improve treatment of BA as it produces positive effect on endogenic oxidative stress, LPO, enzymatic and nonenzymatic ARD, blood and EAC tesigraphy.


CONCLUSIONS
Antiinflammatory effect of GSO in BA is suggested.
Nikitin
A V
AV
Zuĭkova
A A
AA
D000975:Antioxidants; D001249:Asthma / Q000188:drug therapy*; D001944:Breath Tests; D002570:Ceruloplasmin / Q000032:analysis*; D003460:Crystallization; D016166:Free Radical Scavengers / Q000097:blood*; D005980:Glutathione Reductase / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008315:Malondialdehyde / Q000097:blood; D018384:Oxidative Stress; D012138:Respiratory Therapy; D013482:Superoxide Dismutase / Q000097:blood*; D013481:Superoxides / Q000008:administration & dosage*; D013997:Time Factors
D000975:Antioxidants; D016166:Free Radical Scavengers; D013481:Superoxides; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D005980:Glutathione Reductase