title: Neoadjuvant chemotherapy for unresectable ovarian carcinoma: a French multicenter study.
abstract: BACKGROUND
  Initial debulking surgery followed by chemotherapy is the current treatment for International Federation of Gynecology and Obstetrics Stage IIIC/IV ovarian carcinoma but has a limited efficacy when optimal cytoreduction is not achieved at the end of the surgical procedure. An alternative treatment for these patients could be neoadjuvant chemotherapy. The purpose of this retrospective study was to report the results of neoadjuvant chemotherapy in operable patients (no medical contraindication to surgery) presenting with primary unresectable tumors.
  
  
  METHODS
  Between January 1996 and March 1999, operable patients presenting with Stage IIIC or IV ovarian carcinoma underwent, in six French gynecologic oncology departments, surgical staging to evaluate tumor resectability. When the tumor was deemed unresectable by standard surgery, the patient received three to six cycles of platinum-based neoadjuvant chemotherapy according to the response and the center's usual protocol. Patients were surgically explored after completion of neoadjuvant chemotherapy when the tumor did not progress during treatment. Debulking was performed during this secondary surgery when a response to chemotherapy was observed.
  
  
  RESULTS
  Fifty-four patients were treated by neoadjuvant chemotherapy. The first surgical staging procedure was laparoscopy in 33 patients (61%) and laparotomy in 21 patients (39%). The median number of neoadjuvant chemotherapy cycles was 4 (range, 0-6). Forty-three patients (80%) responded to neoadjuvant chemotherapy and then tumors were debulked. Optimal cytoreduction was obtained in 39 patients (91% of the patients who underwent debulking) and with standard surgery in 32 patients (82%). For patients whose tumors were optimally debulked, blood transfusions were administered to 17 patients (43%), median intensive care unit stay was 0 days (range, 0-7 days), and median postoperative hospital stay was 10 days (range, 4-62 days). Median overall survival for the total series was 22 months. Survival was better for patients debulked after neoadjuvant chemotherapy compared with patients with nondebulked tumors (P < 0.001).
  
  
  CONCLUSIONS
  Neoadjuvant chemotherapy for primary unresectable ovarian carcinoma leads to the selection of a subset of patients sensitive to chemotherapy in whom optimal cytoreduction can be achieved after chemotherapy by standard surgery in a high proportion of cases. Conversely, aggressive surgery can be avoided in patients with initial chemoresistance, in whom the prognosis is known to be poor regardless of treatment.
authors: Edouard Herriot Hospital, Lyon Cedex, France. yan.ansquer@wanadoo.fr
authors: Y
authors: Y
authors: Ansquer
authors: E
authors: E
authors: Leblanc
authors: K
authors: K
authors: Clough
authors: P
authors: P
authors: Morice
authors: J
authors: J
authors: Dauplat
authors: P
authors: P
authors: Mathevet
authors: C
authors: C
authors: Lhommé
authors: C
authors: C
authors: Scherer
authors: J D
authors: JD
authors: Tigaud
authors: M
authors: M
authors: Benchaib
authors: E
authors: E
authors: Fourme
authors: D
authors: D
authors: Castaigne
authors: D
authors: D
authors: Querleu
authors: D
authors: D
authors: Dargent
mesh_terms: D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D010535:Laparoscopy; D007902:Length of Stay; D008875:Middle Aged; D015337:Multicenter Studies as Topic; D020360:Neoadjuvant Therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome