title: Follicular variant of papillary thyroid carcinoma: a comparative study of histopathologic features and cytology results in 141 patients.
abstract: OBJECTIVE
  To characterize the histopathologic features of follicular variant of papillary thyroid carcinoma (FVPC) and its cytology results on fine-needle aspiration (FNA) biopsy and compare them with those of papillary thyroid carcinoma (PC).
  
  
  METHODS
  We searched the University of Massachusetts Medical Center pathology database for all surgical specimens associated with a diagnosis of FVPC or PC between January 1992 and February 1998 and reviewed the related pathology reports. In addition, the associated preoperative FNA results were analyzed.
  
  
  RESULTS
  On initial assessment, FVPC was associated with a significantly lower incidence of cervical lymph node metastatic involvement in comparison with PC (5.6% versus 35.7%; P<0.001). Even though the mean size of FVPC was larger than that of PC (2.57 cm versus 1.75 cm; P<0.05), FVPC showed a lower incidence of thyroid capsule invasion (5.6% versus 11.4%), infiltrative resection margins (2.8% versus 20.0%; P = 0.01), local soft tissue invasion (7.0% versus 25.7%; P<0.005), and multicentricity (25.4% versus 47.1%; P<0.01). Lymphocytic thyroiditis was a common feature of both FVPC (36.6%) and PC (35.7%). FNA biopsy revealed the presence of malignant cells in 9.8% of patients with FVPC in comparison with 67.5% of patients with PC. Most cytology specimens of FVPC (58.8%) were interpreted as suspicious for a malignant lesion or as a follicular neoplasm.
  
  
  CONCLUSIONS
  FVPC is associated with a significantly lower incidence of cervical lymph node metastatic lesions and invasive histologic features than is PC. Long-term prospective clinical studies are needed to determine whether these findings translate into a more benign natural history for this variant of PC. Results of FNA biopsy in FVPC are more commonly interpreted as suspicious rather than malignant; this factor has major implications for preoperative planning.
authors: Division of Endocrinology, Department of Pathology, and Department of Surgery, University of Massachusetts School of Medicine, Worcester, Massachusetts, USA.
authors: M
authors: M
authors: Jain
authors: A
authors: A
authors: Khan
authors: N
authors: N
authors: Patwardhan
authors: F
authors: F
authors: Reale
authors: M
authors: M
authors: Safran
mesh_terms: D001707:Biopsy, Needle; D002291:Carcinoma, Papillary / Q000473:pathology; D018265:Carcinoma, Papillary, Follicular / Q000473:pathology*; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000473:pathology*; D013967:Thyroiditis, Autoimmune / Q000473:pathology