title: Aurantiamide acetate, a selective cathepsin inhibitor, produced by Aspergillus penicilloides.
abstract: Aurantiamide acetate was isolated from the fermentation broth of Aspergillus penicilloides for the first time. Aurantiamide acetate inhibited cysteine proteinases, in particular, cathepsin L (3.4.22.15) and B (3.4.22.1) with IC50 of 12 microM and 49 microM, respectively. In the adjuvant-arthritic rat model, subcutaneously administered 10 mg/kg body weight of this compound suppressed hind paw swelling.
authors: Lead Generation Research Laboratory at Toda, Tanabe Seiyaku Co., Ltd., Saitama, Japan.
authors: K
authors: K
authors: Isshiki
authors: Y
authors: Y
authors: Asai
authors: S
authors: S
authors: Tanaka
authors: M
authors: M
authors: Nishio
authors: T
authors: T
authors: Uchida
authors: T
authors: T
authors: Okuda
authors: S
authors: S
authors: Komatsubara
authors: N
authors: N
authors: Sakurai
mesh_terms: D001230:Aspergillus / Q000378:metabolism*; D002403:Cathepsins / Q000037:antagonists & inhibitors*; D015853:Cysteine Proteinase Inhibitors / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D013057:Spectrum Analysis
chemical_list: D015853:Cysteine Proteinase Inhibitors; D004151:Dipeptides; C011670:N-benzoylphenylalanylphenylalinol acetate; D002403:Cathepsins