Effect of thyroid hormone on the alcohol dehydrogenase activities in rat tissues.
The effects of thyroid hormone on hepatic and gastric alcohol dehydrogenase (ADH) activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with thyroxine (1 mg/kg, po) for 14 days. Whereas hepatic ADH activity in thyroxine-treated rats decreased by 61.3% of control rats (26.4 vs 43.2, p<0.001), gastric ADH activity increased by 262.9% of control rats (4.9 vs 1.9, p<0.001). As for the activities of the lung and kidney, thyroxine treatment did not produce any statistically significant changes. These data suggest that thyrotoxicosis causes a decrease of hepatic alcohol metabolism, and that the increase of gastric ADH activity in thyrotoxic rats can partly restore the first-pass metabolism of ethanol.
Kim
D S
DS
Department of Internal Medicine, College of Medicine, Hanyang University, Seoul, Korea. dskim@hmc.hanyang.ac.kr
Lee
C B
CB
Park
Y S
YS
Ahn
Y H
YH
Kim
T W
TW
Kee
C S
CS
Kang
J S
JS
Om
A S
AS
D000426:Alcohol Dehydrogenase / Q000378:metabolism*; D000818:Animals; D005753:Gastric Mucosa / Q000201:enzymology; D007668:Kidney / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008168:Lung / Q000201:enzymology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013270:Stomach / Q000187:drug effects / Q000201:enzymology*; D013971:Thyrotoxicosis / Q000139:chemically induced / Q000378:metabolism; D013974:Thyroxine / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology
D000426:Alcohol Dehydrogenase; D013974:Thyroxine