title: An autopsy case of pancreatic and ectopic nesidioblastosis.
abstract: We report an autopsy case of pancreatic and ectopic nesidioblastosis. A five-month-old Japanese girl was born at 35 weeks gestation, and showed clinical symptoms of hyper-insulinemic hypoglycemia before death. At autopsy a tumorous nodule was observed at the portion of the jejunum, 90 cm from Treitz's ligament. The nodule measured 30 x 20 x 20 mm. The ectopic pancreas, also revealed nesidioblastosis histologically. Immunohistologically, both nesidioblastoses were stained positive for chromogranin A, insulin, glucagon and somatostatin. The proliferating cell nuclear antigen (PCNA) and Ki-67 indices were less than 4% in the nesidioblastosis. To our knowledge, this is the first reported case of nesidioblastosis demonstrating proliferating activity with PCNA and Ki-67, and is the third reported case of nesidioblastosis arising in the pancreas and ectopic pancreas.
authors: Departments of Surgical Pathology and; Pediatrics, Hyogo College of Medicine, Nishinomiya, Japan. h-pathol@hyo-med.ac.jp
authors: H
authors: H
authors: Yasoshima
authors: Y
authors: Y
authors: Nakata
authors: E
authors: E
authors: Ohkubo
authors: Y
authors: Y
authors: Matsuno
authors: K
authors: K
authors: Sakurai
authors: A
authors: A
authors: Kubota
authors: K
authors: K
authors: Minagawa
mesh_terms: D002828:Choristoma / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D005865:Gestational Age; D006801:Humans; D006946:Hyperinsulinism / Q000209:etiology / Q000473:pathology; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D007580:Jejunal Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D019394:Ki-67 Antigen / Q000378:metabolism; D010179:Pancreas / Q000378:metabolism / Q000473:pathology*; D010182:Pancreatic Diseases / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism
chemical_list: D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen