title: Coordination between transcription and pre-mRNA processing.
abstract: A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing.
authors: Laboratorio de Fisiología y Biología Molecular, Departamento de Ciencias Biológicas, Universidad de Buenos Aires, Ciudad Universitaria, Argentina.
authors: P
authors: P
authors: Cramer
authors: A
authors: A
authors: Srebrow
authors: S
authors: S
authors: Kadener
authors: S
authors: S
authors: Werbajh
authors: M
authors: M
authors: de la Mata
authors: G
authors: G
authors: Melen
authors: G
authors: G
authors: Nogués
authors: A R
authors: AR
authors: Kornblihtt
mesh_terms: D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D012322:RNA Precursors / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D012326:RNA Splicing; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*
chemical_list: D046911:Macromolecular Substances; D012322:RNA Precursors; D012319:RNA Polymerase II