title: Plasmacytoid dendritic cells are highly susceptible to human immunodeficiency virus type 1 infection and release infectious virus.
abstract: Plasmacytoid dendritic cells (pcDC) and myeloid dendritic cells (myDC) are shown to express CD4 and low levels of CCR5 and CXCR4, but only myDC express DC SIGN, a C-type lectin that binds human immunodeficiency virus but does not mediate virus entry. Both DC types were more susceptible to infection with a macrophage than a lymphotropic strain of human immunodeficiency virus type 1, but pcDC were more readily infected than myDC.
authors: Department of Immunology, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, United Kingdom. s.patterson@ic.ac.uk
authors: S
authors: S
authors: Patterson
authors: A
authors: A
authors: Rae
authors: N
authors: N
authors: Hockey
authors: J
authors: J
authors: Gilmour
authors: F
authors: F
authors: Gotch
mesh_terms: D015704:CD4 Antigens / Q000032:analysis / Q000235:genetics; D015815:Cell Adhesion Molecules; D002478:Cells, Cultured; D004279:DNA, Viral / Q000032:analysis; D003713:Dendritic Cells / Q000276:immunology / Q000821:virology*; D005434:Flow Cytometry; D015497:HIV-1 / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D037102:Lectins / Q000032:analysis / Q000235:genetics; D037181:Lectins, C-Type; D011533:Proviruses / Q000302:isolation & purification; D012333:RNA, Messenger / Q000032:analysis; D019713:Receptors, CCR5 / Q000032:analysis / Q000235:genetics; D019718:Receptors, CXCR4 / Q000032:analysis / Q000235:genetics; D011956:Receptors, Cell Surface / Q000032:analysis / Q000235:genetics; D020133:Reverse Transcriptase Polymerase Chain Reaction; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
chemical_list: D015704:CD4 Antigens; D015815:Cell Adhesion Molecules; D004279:DNA, Viral; D037102:Lectins; D037181:Lectins, C-Type; D012333:RNA, Messenger; D019713:Receptors, CCR5; D019718:Receptors, CXCR4; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin