Blockade of hyperpolarizing currents produces a dose-dependent effect on heart rate.
Intravenous injection of ZD 7288, a new specific hyperpolarizing current blocker, dose-dependently reduces heart rate in adult rats. The autonomic nervous system modulates changes in heart rate caused by hyperpolarizing currents.
Ziyatdinova
N I
NI
Department of Human Anatomy, Physiology, and Health Care, Kazan State Pedagogical University.
Giniatullin
R A
RA
Svyatova
N V
NV
Zefirov
T L
TL
D000818:Animals; D002317:Cardiovascular Agents / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D007275:Injections, Intravenous; D008564:Membrane Potentials / Q000187:drug effects*; D011743:Pyrimidines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D002317:Cardiovascular Agents; D011743:Pyrimidines; C082246:ICI D2788