Novel macrolactins as antibiotic lactones from a marine bacterium.
Seven new macrolactins (named G~M) and known macrolactins A and F were isolated from a culture broth of Bacillus sp. PP19-H3. The strain had been isolated from the macroalga, Schizymenia dubyi. Macrolactin A, which was 24-membered lactone, had previously been reported to show antibacterial, cytotoxic and antiviral activities. The new macrolactins include 22-membered ring or dicyclic lactone in addition to geometric isomers of known macrolactins A and F. The antibacterial activities of all the macrolactins examined in this study were relatively weak.
Nagao
T
T
Shimizu Laboratories, Marine Biotechnology Institute Co Ltd, Shizuoka, Japan.
Adachi
K
K
Sakai
M
M
Nishijima
M
M
Sano
H
H
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification*; D001407:Bacillus / Q000737:chemistry* / Q000145:classification; D005285:Fermentation; D007783:Lactones / Q000138:chemical synthesis / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D000461:Rhodophyta / Q000737:chemistry; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D007783:Lactones