Collagen membrane/fleece composite film reduces adhesions in the presence of bleeding in a rabbit uterine horn model.
OBJECTIVE
Determination of efficacy in presence of bleeding of CDS, a collagen/membrane fleece composite, in a rabbit uterine horn simple abrasion model.


METHODS
Randomized, controlled, and blinded study involving standard abrasion of the uterine horns with induction of moderate mesouterine bleeding.


METHODS
Research laboratory.


METHODS
New Zealand White rabbits.


METHODS
No treatment (surgical control), CDS film, or INTERCEED barrier (negative reference control). MAIN OUTCOME MEASURE(S) AND RESULT(S): The extent (percent length uterine horn) with adhesions was assessed after 29 or 30 days. Adhesions formed in surgical controls to an extent (85.6% +/- 4.6%) consistent with historic data for this model. INTERCEED failed to reduce adhesions (78.1% +/- 7.7%) indicating that the test conditions of inadequate hemostasis were validated. CDS film, despite this inadequate hemostasis, reduced the extent of adhesions (31% +/- 7.4%; P<.01). Both the tenacity (P=.0008) and degree of uterine convolution (P=.000003) was reduced by CDS film but not by INTERCEED.


CONCLUSIONS
Under conditions of inadequate hemostasis CDS effected a reduction in adhesion development. CDS may be useful adjuvant for procedures where hemostasis is difficult to achieve.
Wiseman
D M
DM
Synechion, Inc., Dallas, Texas, USA. david.wiseman@adhesions.org
Gravagna
P
P
Bayon
Y
Y
Tayot
J
J
D000818:Animals; D002483:Cellulose, Oxidized; D003094:Collagen; D005260:Female; D006487:Hemostasis; D008567:Membranes, Artificial; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control; D014591:Uterine Diseases / Q000517:prevention & control*; D014592:Uterine Hemorrhage / Q000503:physiopathology*
D002483:Cellulose, Oxidized; C060002:INTERCEED; D008567:Membranes, Artificial; D003094:Collagen