Aromatic sialic acid analogues as potential inhibitors of influenza virus neuraminidase.
The influenza virus neuraminidase (NA) is an enzyme essential for viral infection and offers a potential target for antiviral drug development. We aimed our research at the synthesis of non-carbohydrate molecules able to inhibit NA as transition-state analogues. Aromatic sialic acid analogues (compound 5 and compound 10) were synthesised in good yields starting from commercially available benzoic acids using a suitable synthetic strategy.
Bianco
A
A
Dipartimento di Chimica, Università La Sapienza, Rome, Italy. armandodoriano.bianco@uniroma1.it
Brufani
M
M
Melchioni
C
C
D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology*; D006801:Humans; D007202:Indicators and Reagents; D009980:Influenza A virus / Q000201:enzymology; D009981:Influenza B virus / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D009439:Neuraminidase / Q000037:antagonists & inhibitors*; D009975:Orthomyxoviridae / Q000187:drug effects / Q000201:enzymology*; D012794:Sialic Acids / Q000138:chemical synthesis* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D012794:Sialic Acids; D009439:Neuraminidase