title: A series of enediynes as novel inhibitors of topoisomerase I.
abstract: A series of acyclic enediynes, 2-((6-substituted)-3-hexen-1,5-diynyl)benzonitriles (8--11), display potent inhibition against topoisomerase I without the formation of active biradical intermediates and show inhibitory activity against topoisomerase I at 10 microM, which is five times that of camptothecin from the results of agarose gel electrophoresis.
authors: School of Chemistry, Kaohsiung Medical University, Kaohsiung, Taiwan.
authors: C F
authors: CF
authors: Lin
authors: P C
authors: PC
authors: Hsieh
authors: W D
authors: WD
authors: Lu
authors: H F
authors: HF
authors: Chiu
authors: M J
authors: MJ
authors: Wu
mesh_terms: D002166:Camptothecin / Q000494:pharmacology; D004587:Electrophoresis, Agar Gel; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D009570:Nitriles / Q000494:pharmacology*; D059004:Topoisomerase I Inhibitors
chemical_list: D004791:Enzyme Inhibitors; D009570:Nitriles; D059004:Topoisomerase I Inhibitors; C014356:benzonitrile; D002166:Camptothecin