PET with 11C-deuterium-deprenyl and 18F-FDG in focal epilepsy.
OBJECTIVE
This study compares positron emission tomography (PET) using 11C-deuterium-deprenyl (DED) with PET using 18F-fluorodeoxyglucose(18F-FDG) for examining epileptogenic regions in patients with focal epilepsy.


METHODS
Twenty-three patients undergoing evaluation for epilepsy surgery were subjected to PET with DED. Fourteen patients had mesial temporal lobe epilepsy (TLE) and 9 patients had seizures of neocortical origin. In addition, 6 healthy control subjects were examined. Pixel-by-pixel analysis was used to generate graphical images of tracer distribution volume (intercept) and the accumulation rate (slope). Asymmetries with respect to relative intercept and slope were compared in patients with temporal lobe epilepsy (TLE), in patients with extra-temporal lobe epilepsy (exTLE), and in the control subjects. The results were compared with 18F-FDG-PET.


RESULTS
Among the patients with TLE, significant differences between the epileptogenic and the contralateral lobe were found with DED intercept and FDG-uptake. No significant differences were found with DED slope. The exTLE and the control groups showed no significant differences between sides or lobes.


CONCLUSIONS
This study indicates that PET with 11C-deuterium-deprenyl is a useful method for identifying TLE and is equivalent to PET with 18F-FDG in this sense. The method has little localizing value in seizures originating from neocortical structures.
Kumlien
E
E
Department of Neuroscience, Neurology and Uppsala University PET Centre, University Hospital, S-751 85 Uppsala, Sweden. Eva.Kumlien@neurologi.uu.se
Nilsson
A
A
Hagberg
G
G
Långström
B
B
Bergström
M
M
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000378:metabolism; D003903:Deuterium / Q000378:metabolism; D004338:Drug Combinations; D004828:Epilepsies, Partial / Q000175:diagnosis*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis*; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism; D015999:Multivariate Analysis; D019275:Radiopharmaceuticals / Q000378:metabolism; D012642:Selegiline / Q000378:metabolism; D014055:Tomography, Emission-Computed
D004338:Drug Combinations; D008996:Monoamine Oxidase Inhibitors; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18; D012642:Selegiline; D003903:Deuterium; D005947:Glucose