title: Vascular dementia: a cognitive SPET-CBF activation study.
abstract: OBJECTIVE
  We investigated the pattern of regional cerebral blood flow (rCBF) responses to a cognitive task in vascular patients with and without dementia.
  
  
  METHODS
  We studied 8 controls and 18 vascular patients by quantitative rCBF assessed by (133)Xe inhalation method and SPET, both at rest and during a cognitive figure recognition task. Eight were mildly demented and 10 were nondemented vascular patients. According to their task performance, 12 patients were classified as 'good performers' (GPs) and 6 patients as 'poor performers' (PPs).
  
  
  RESULTS
  Vascular patients activated a larger number of brain areas than controls. No differences were observed between controls, nondemented and mildly demented patients in the pattern of rCBF activation. GPs presented a lower mean percentage of rCBF increase than either controls or PPs. GPs had lower values than PPs in the left temporal, parietal and occipital regions and in the right posterior cingulate and occipital regions.
  
  
  CONCLUSIONS
  These data suggest that vascular patients may functionally compensate for vascular damage by activating more brain areas than controls do and, consequently, by increasing the rate of regional activation.
authors: Department of Neurological Sciences, University of Rome 'La Sapienza', Rome, Italy.
authors: V
authors: V
authors: Di Piero
authors: M
authors: M
authors: Giannini
authors: M
authors: M
authors: Bragoni
authors: E
authors: E
authors: Vicenzini
authors: S
authors: S
authors: Di Legge
authors: M
authors: M
authors: Altieri
authors: P
authors: P
authors: Pantano
authors: G L
authors: GL
authors: Lenzi
mesh_terms: D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000502:physiology*; D003071:Cognition / Q000502:physiology*; D015140:Dementia, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010775:Photic Stimulation; D013647:Task Performance and Analysis; D015899:Tomography, Emission-Computed, Single-Photon