The phylogeography of Y chromosome binary haplotypes and the origins of modern human populations.
Although molecular genetic evidence continues to accumulate that is consistent with a recent common African ancestry of modern humans, its ability to illuminate regional histories remains incomplete. A set of unique event polymorphisms associated with the non-recombining portion of the Y-chromosome (NRY) addresses this issue by providing evidence concerning successful migrations originating from Africa, which can be interpreted as subsequent colonizations, differentiations and migrations overlaid upon previous population ranges. A total of 205 markers identified by denaturing high performance liquid chromatography (DHPLC), together with 13 taken from the literature, were used to construct a parsimonious genealogy. Ancestral allelic states were deduced from orthologous great ape sequences. A total of 131 unique haplotypes were defined which trace the microevolutionary trajectory of global modern human genetic diversification. The genealogy provides a detailed phylogeographic portrait of contemporary global population structure that is emblematic of human origins, divergence and population history that is consistent with climatic, paleoanthropological and other genetic knowledge.
Underhill
P A
PA
Department of Genetics, Stanford University, CA 94305-5120, USA. under@stanford.edu
Passarino
G
G
Lin
A A
AA
Shen
P
P
Mirazón Lahr
M
M
Foley
R A
RA
Oefner
P J
PJ
Cavalli-Sforza
L L
LL
D000349:Africa; D000483:Alleles; D005075:Biological Evolution; D002851:Chromatography, High Pressure Liquid; D004272:DNA, Mitochondrial / Q000378:metabolism; D004641:Emigration and Immigration; D019143:Evolution, Molecular; D005843:Geography; D006239:Haplotypes; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017422:Sequence Analysis, DNA; D014998:Y Chromosome
D004272:DNA, Mitochondrial