Alpha 2-adrenoceptor activity induces the antidepressant-like glycolipid in mouse forced swimming.
Antidepressants show an antidepressive-like behavioral effect on mouse forced swimming via induction of GalNAc alpha 1-3GalNAc-lipid. In order to detect the mechanisms of the neuron receptor activities on the effect, the glycolipid reactivities in the serum induced by tandospirone, a specific 5-HT1A receptor agonist, and clonidine, a specific alpha 2-adrenoceptor agonist, were investigated. Both of these agonists showed dose-dependent behavioral effects which were decreased by pretreatment with yohimbine, a specific alpha 2-adrenoceptor antagonist. The glycolipid reactivities corresponded with the effects. These present findings strongly suggest that alpha 2-adrenoceptor activity in the brain mediates the induction of the antidepressant glycolipid in the forced swimming test.
Masuda
Y
Y
Psychosomatic Division, Akita University School of Medicine, Akita, Japan.
Ohnuma
S
S
Sugiyama
T
T
D000316:Adrenergic alpha-Agonists / Q000494:pharmacology*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology*; D004347:Drug Interactions; D005915:Globosides / Q000494:pharmacology; D054833:Isoindoles; D008297:Male; D051379:Mice; D010879:Piperazines / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects*; D013550:Swimming
D000316:Adrenergic alpha-Agonists; D014151:Anti-Anxiety Agents; D005915:Globosides; D054833:Isoindoles; D010879:Piperazines; D011743:Pyrimidines; D011942:Receptors, Adrenergic, alpha; C055267:tandospirone; C010163:Forssman glycolipid; D003000:Clonidine