title: Steroidal glycosides from the bulbs of Camassia leichtlinii and their cytotoxic activities.
abstract: Phytochemical analysis of the bulbs of Camassia leichtlinii (Liliaceae) resulted in the isolation of six new spirostanol saponins, a new furostanol saponin, a cholestane glucoside, and four known steroidal saponins. The structures of the new saponins were determined by detailed analysis of their spectral data, including two-dimensional NMR spectroscopy, and by the results of hydrolytic cleavage. Cytotoxic activities of the isolated compounds against human oral squamous cell carcinoma (HSC-2) cells and normal human gingival fibroblasts (HGF) are also reported.
authors: Laboratory of Medicinal Plant Science, School of Pharmacy, Tokyo University of Pharmacy and Life Science, Hachioji, Japan. mimakiy@ps.toyaku.ac.jp
authors: M
authors: M
authors: Kuroda
authors: Y
authors: Y
authors: Mimaki
authors: F
authors: F
authors: Hasegawa
authors: A
authors: A
authors: Yokosuka
authors: Y
authors: Y
authors: Sashida
authors: H
authors: H
authors: Sakagami
mesh_terms: D002240:Carbohydrate Sequence; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019668:Liliaceae / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D013256:Steroids / Q000737:chemistry*
chemical_list: D006027:Glycosides; D013256:Steroids