Investigation of serum response to PMP22, connexin 32 and P(0) in inflammatory neuropathies.
We investigated serological immune responses against three major peripheral nerve myelin constituents in patients with immune-mediated neuropathies. Connexin 32 (Cx32), myelin protein zero (MPZ, P(0)) and peripheral myelin protein 22 (PMP22) were produced in Chinese hamster ovary (CHO)-K1 cells. From a panel of 25 Guillain-Barré syndrome (GBS) and 24 chronic inflammatory demyelinating polyneuropathy (CIDP) patients, only two patients showed reactivity towards Cx32 and P(0).
Kwa
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Department of Neurology, Academic Medical Center, University of Amsterdam, Lab Neurozintuigen, K2 room 219, PO Box 22660, 1100 DD, Amsterdam, Netherlands. m.s.kwa@AMC.UVA.NL
van Schaik
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D000818:Animals; D001323:Autoantibodies / Q000097:blood*; D016466:CHO Cells; D017630:Connexins / Q000235:genetics / Q000276:immunology*; D006224:Cricetinae; D015870:Gene Expression; D020275:Guillain-Barre Syndrome / Q000276:immunology*; D006801:Humans; D008856:Microscopy, Fluorescence; D018993:Myelin P0 Protein / Q000235:genetics / Q000276:immunology*; D009185:Myelin Proteins / Q000235:genetics / Q000276:immunology*; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000276:immunology; D011994:Recombinant Proteins / Q000276:immunology; D014162:Transfection; D000097002:Gap Junction beta-1 Protein
D001323:Autoantibodies; D017630:Connexins; D018993:Myelin P0 Protein; D009185:Myelin Proteins; D011994:Recombinant Proteins; D000097002:Gap Junction beta-1 Protein; C073687:PMP22 protein, human