CR1 and CR1-like: the primate immune adherence receptors.
Immune adherence describes the phenomenon in which complement-opsonized substrates, such as immune complexes (IC), viruses, or bacteria, are bound by primate erythrocytes via erythrocyte complement receptors. In vivo studies have shown that this binding allows the erythrocyte to act as an inert shuttle, targeting IC to the monocyte phagocytic system and away from vulnerable tissue. Thus, immune adherence appears to play an integral role in the primate in promoting the safe clearance of circulating IC and preventing IC-mediated pathologies. The complement receptors that mediate immune adherence comprise two unique but closely related gene products, either the type one complement receptor (CRI) in humans or CRI-like in non-human primates. This review focuses on the structure, function, and physiological role of the primate immune adherence receptors.
Birmingham
D J
DJ
The Department of Internal Medicine, The Heart and Lung Research Institute, The Ohio State University, Columbus 43210, USA. birmingham-1@medctr.osu.edu
Hebert
L A
LA
D000483:Alleles; D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood / Q000276:immunology; D001419:Bacteria / Q000276:immunology; D002448:Cell Adhesion; D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D003167:Complement Activation; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000276:immunology*; D005544:Forecasting; D006801:Humans; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D008252:Macaca fascicularis / Q000097:blood / Q000276:immunology; D009895:Opsonin Proteins / Q000276:immunology; D002679:Pan troglodytes / Q000097:blood / Q000276:immunology; D010215:Papio / Q000097:blood / Q000276:immunology; D011323:Primates / Q000097:blood / Q000276:immunology*; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics; D017463:Receptors, Complement 3b / Q000737:chemistry / Q000235:genetics / Q000276:immunology*; D020449:Repetitive Sequences, Amino Acid; D013154:Spleen / Q000378:metabolism; D013329:Structure-Activity Relationship; D014780:Viruses / Q000276:immunology
D000936:Antigen-Antibody Complex; D008024:Ligands; D009895:Opsonin Proteins; D020033:Protein Isoforms; D017463:Receptors, Complement 3b