title: Avoiding early postoperative complications in liver surgery. A multivariate analysis of 254 patients consecutively observed.
abstract: BACKGROUND
  The number of hepatic resections for benign and malignant lesions has constantly increased over the past 20 years, as a consequence, surgical experience acquired over the past few years has decreased post-operative morbidity and mortality rates.
  
  
  OBJECTIVE
  Analysing the relation between potential preoperative risk factors and the occurrence of severe post-operative complications, an attempt is made to identify the variables determining surgical risk in elective hepatic surgery both in normal and cirrhotic liver.
  
  
  METHODS
  The hospital records of 254 patients who underwent elective liver surgical procedures for hepatic lesions in our department, between 1984 and 1999, were reviewed. The following variables were entered into univariate and multivariate analysis: age, sex, nature of liver lesion (benign or malignant), presence of cirrhosis or cholestasis, synchronous resection of other organs, disorders of blood coagulation, intraoperative blood requirement, the extent of surgical procedures and Pringle's manoeuvre.
  
  
  CONCLUSIONS
  The multivariate analysis of the 254 surgical operations on the liver indicates that the most powerful independent predictors favouring a serious adverse effect includes intra-operative blood transfusions, advanced age and cirrhosis. Scrupulous preoperative clinical evaluation and expert surgical skills minimize intra-operative bleeding and proved to be the most significant factors influencing morbidity and mortality rates.
authors: Department of Digestive Surgery, Catholic University, Rome, Italy. sergioalfieri@yahoo.it
authors: S
authors: S
authors: Alfieri
authors: C
authors: C
authors: Carriero
authors: P
authors: P
authors: Caprino
authors: A
authors: A
authors: Di Giorgio
authors: A
authors: A
authors: Sgadari
authors: F
authors: F
authors: Crucitti
authors: G B
authors: GB
authors: Doglietto
mesh_terms: D000367:Age Factors; D001803:Blood Transfusion / Q000706:statistics & numerical data; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008103:Liver Cirrhosis / Q000453:epidemiology; D008107:Liver Diseases / Q000601:surgery; D008113:Liver Neoplasms / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D015999:Multivariate Analysis; D011183:Postoperative Complications / Q000453:epidemiology / Q000517:prevention & control*; D012307:Risk Factors