title: Pharmacological control of cough.
abstract: Cough constitutes an important medical problem in all ages. Although treatment of underlying pathologies, e.g., bronchial asthma, upper respiratory tract infection, etc. is well justified to cure cough, non-specific therapy in the form of a number of antitussive agents like, codeine, dextromethorphan, etc. is widely practiced to suppress it. Most of these agents are efficacious and well-tolerated. Nevertheless, CNS toxicities may occur in new-borns, especially those with immature metabolic profile. Some recent reports about interactions (involving hepatic cytochrome P450 enzymes) between dextromethorphan and other drugs are also noteworthy.
authors: Department of Pharmacology, All India Institute of Medical Sciences, New Delhi.
authors: S K
authors: SK
authors: Maulik
authors: M
authors: M
authors: Maulik
mesh_terms: D000996:Antitussive Agents / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D003371:Cough / Q000188:drug therapy*; D004347:Drug Interactions / Q000502:physiology; D006634:Histamine H1 Antagonists / Q000627:therapeutic use; D006801:Humans; D009294:Narcotics / Q000627:therapeutic use
chemical_list: D000996:Antitussive Agents; D001993:Bronchodilator Agents; D018680:Cholinergic Antagonists; D006634:Histamine H1 Antagonists; D009294:Narcotics