A pendular mechanism for maintenance of the immune memory.
A possible mechanism for maintaining immune memory, based on idiotypic-anti-idiotypic interactions, is described. It is proposed that pendular dynamic swings in the levels of idiotypic antibodies (Ab1) and anti-idiotypic Ab2 may underlay immune memory. In the terms of the advanced concept, Ab dynamics in the maternal body might also play a significant role in education of the neonatal immune system.
Seledtsov
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VI
Immunohematologic Department, Institute of Clinical Immunology, Novosibirsk, Russia. vs@online.nsk.su
Seledtsova
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GV
D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001826:Body Fluids / Q000276:immunology; D006801:Humans; D007156:Immunologic Memory; D007231:Infant, Newborn
D000888:Antibodies, Anti-Idiotypic