[Treatment of therapy refractory verrucae vulgares with a ciclopirox-containing lacquer].
OBJECTIVE
Anti-inflammatory actions of ciclopirox, an antifungal agent, have been described previously. We assessed the effectiveness of ciclopirox in the treatment of viral warts.


METHODS
Twenty-three immunocompetent patients (age 9-61 years) with common warts at the hands, feet and in the face resistant to conventional therapy were treated. Following keratolysis with a salicylic acid-containing patch, an 8% ciclopirox lacquer was applied 1-2 times daily. At the beginning and the end of the treatment lesions were photographed and the time span (minimum 4 weeks) until complete resolution was documented.


RESULTS
In 7 patients complete remission, and in 12 patients partial remission was achieved. Only 4 patients did not show any effect under topical ciclopirox treatment (mean duration of therapy 3.2 +/- 2.1 months). The overall response rate was 82.6%. Local side effects like erythema or pruritus were not reported.


CONCLUSIONS
Our data suggest that a ciclopirox lacquer may be helpful in the treatment of common warts. However, the data have to be confirmed in a randomized controlled trial in the future.
Szeimies
R M
RM
Klinik und Poliklinik für Dermatologie, Klinikum der Universität Regensburg, 93042 Regensburg. Rolf-Markus.Szeimies@klinik.uni-regensburg.de
Wimmershoff
M B
MB
Reisberger
E M
EM
Landthaler
M
M
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D002648:Child; D000077768:Ciclopirox; D004334:Drug Administration Schedule; D005148:Facial Dermatoses / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D005533:Foot Dermatoses / Q000188:drug therapy*; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011728:Pyridones / Q000008:administration & dosage*; D016896:Treatment Outcome; D014860:Warts / Q000188:drug therapy*
D000935:Antifungal Agents; D011728:Pyridones; D000077768:Ciclopirox