title: A novel anti-HIV macrocyclic peptide from Palicourea condensata.
abstract: A 37 amino acid cyclic polypeptide has been isolated from the organic extract of the tropical tree Palicourea condensata. Palicourein (1) is the largest of a growing family of plant peptides that contain a cyclized amino acid backbone cross-linked via three internal disulfide bridges. Palicourein inhibits the in vitro cytopathic effects of HIV-1RF infection of CEM-SS cells with an EC50 value of 0.1 microM and an IC50 value of 1.5 microM.
authors: Laboratory of Drug Discovery Research and Development, Division of Basic Sciences, NCI-Frederick, Frederick, Maryland 21702-1201, USA.
authors: H R
authors: HR
authors: Bokesch
authors: L K
authors: LK
authors: Pannell
authors: P K
authors: PK
authors: Cochran
authors: R C
authors: RC
authors: Sowder
authors: T C
authors: TC
authors: McKee
authors: M R
authors: MR
authors: Boyd
mesh_terms: D000595:Amino Acid Sequence; D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured; D002851:Chromatography, High Pressure Liquid; D047169:Cyclotides; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D004220:Disulfides / Q000032:analysis; D006801:Humans; D008969:Molecular Sequence Data; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D011487:Protein Conformation; D019666:Rubiaceae / Q000737:chemistry*; D014197:Trees / Q000737:chemistry
chemical_list: D019380:Anti-HIV Agents; D047169:Cyclotides; D004220:Disulfides; D010456:Peptides, Cyclic; C433585:palicourein