title: Intra-amygdala spermidine administration improves inhibitory avoidance performance in rats.
abstract: In the present study, we investigated the effect of immediate post-training bilateral infusion of spermidine, a polyamine agonist, into the amygdala on inhibitory avoidance learning of rats. Bilateral microinjection of spermidine (0.02--20 nmol) caused an increase in test step-down latencies at high concentrations. Administration of arcaine (0.002--0.2 nmol), an antagonist of the NMDA receptor polyamine binding site, decreased test step-down latencies. On the other hand, co-administration of arcaine and spermidine completely reversed the spermidine-induced increase of test step-down latencies. These results provide evidence that polyamines may be involved in learning and memory modulation in the amygdala.
authors: Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, 97105-900 Santa Maria, RS, Brazil. marubin@quimica.ufsm.br
authors: M A
authors: MA
authors: Rubin
authors: J A
authors: JA
authors: Stiegemeier
authors: M A
authors: MA
authors: Volkweis
authors: D M
authors: DM
authors: Oliveira
authors: A C
authors: AC
authors: Fenili
authors: R L
authors: RL
authors: Boemo
authors: A
authors: A
authors: Jurach
authors: C F
authors: CF
authors: Mello
mesh_terms: D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D001645:Biguanides / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D013095:Spermidine / Q000494:pharmacology*
chemical_list: D001645:Biguanides; C006624:arcaine; D013095:Spermidine