Catalytic and highly efficient 1,4-addition of terminal alkynes to conjugated enones by [RuCl(2)(p-cymene)]2/pyrrolidine.
[reaction: see text] A wide range of terminal alkynes was added to conjugated enones in a 1,4-fashion by a ruthenium catalyst in the presence of catalytic amounts of an amine base, and the corresponding gamma,delta-alkynyl ketones were obtained in good to excellent yields.
Chang
S
S
Department of Chemistry, Ewha Womans University, Seoul 120-750, Korea. sbchang@mm.ewha.ac.kr
Na
Y
Y
Choi
E
E
Kim
S
S