title: Maximal respiratory pressures in myasthenia gravis. Relation to single fiber electromyography.
abstract: OBJECTIVE
  The respiratory muscle weakness was evaluated in mild forms of myasthenia gravis (MG) and was compared with single fiber electromyography results (SFEMG) in the extensor digitorum communis muscle.
  
  
  METHODS
  We assessed 61 treated MG patients without clinical respiratory involvement (13 ocular forms, 28 form IIa and 20 form IIb patients) by maximal respiratory pressure (MRP) to ascertain whether they were consistent with SFEMG results.
  
  
  RESULTS
  Maximal expiratory pressure (MEP) and maximal inspiratory pressure (MIP) were reduced below the lower limit for healthy subjects in 85% and 77% of ocular patients; in 93% and 89% of form IIa, respectively; and in 95% of form IIb. The highest percentage of MEP and MIP reduction showed a positive correlation with increased jitter (r=0.45, P<0.001; r=0.27; P<0.05 respectively) and impulse blocking (r=0.35, P<0.01; r=0.28, P<0.05 respectively).
  
  
  CONCLUSIONS
  We consider MRP measure useful for assessing respiratory muscle weakness in MG patients with subclinical respiratory involvement.
authors: Department of Neurology, Dr Negrin Hospital, Las Palmas, Grand Canary, Spain. mmunozf@meditex.es
authors: C M
authors: CM
authors: Fernández
authors: E D
authors: ED
authors: Tejedor
authors: A
authors: A
authors: Frank
authors: J M
authors: JM
authors: Pino
authors: C P
authors: CP
authors: Conde
authors: P
authors: P
authors: Barreiro
mesh_terms: D000328:Adult; D004576:Electromyography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D008451:Maximal Voluntary Ventilation / Q000502:physiology*; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000502:physiology; D009157:Myasthenia Gravis / Q000175:diagnosis* / Q000503:physiopathology*; D011312:Pressure; D012132:Respiratory Muscles / Q000294:innervation* / Q000503:physiopathology*; D012720:Severity of Illness Index; D009435:Synaptic Transmission / Q000502:physiology