Plasma ferritin and type 2 diabetes mellitus: a critical review.
Multiple factors appear to be involved in the pathogenesis of type 2 (non insulin dependent) diabetes mellitus (DM). One of these factors may be iron overload. This critical review summarizes the major studies on the link between type 2 DM, insulin resistance, glycemic control, diabetic complications and hyperferritinemia. Although some studies suggested that plasma ferritin concentration is positively correlated with insulin resistance and with the risk of acquiring type 2 DM, substantial iron overload is not a typical feature of DM. There is no correlation between plasma ferritin level and glycemic control or diabetic microangiopathic complications.
Eshed
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Department of Medicine, Meir Hospital, Kfar Saba and Sackler Faculty of Medicine, Tel-Aviv University, Israel.
Elis
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Lishner
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M
D001786:Blood Glucose / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005293:Ferritins / Q000097:blood*; D006801:Humans; D007333:Insulin Resistance; D019190:Iron Overload / Q000150:complications; D016239:MEDLINE
D001786:Blood Glucose; D005293:Ferritins