Abnormalities of human genetic apparatus manifested in leukocyte proteins in psoriasis.
The content of 53K/H2A and 43K/H2A proteins in leukocytes of patients with psoriasis, newborns, and healthy donors was studied. In all patients one or both parameters differed from normal. Mean values and distribution of 53K/H2A in healthy siblings of psoriatic proband significantly differed from those in newborns and donors. It was concluded that 53K/H2A is a marker of pathological changes in the genome responsible for predisposition to psoriasis. This marker can be revealed in peripheral blood leukocytes before skin manifestations of the disease.
Paponov
V D
VD
Medical Genetic Center, Russian Academy of Medical Science, Moscow. v_paponov@mail.ru
Suntsova
I G
IG
Baidakova
G V
GV
Mordovtsev
V N
VN
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000235:genetics*; D016022:Case-Control Studies; D002648:Child; D020022:Genetic Predisposition to Disease; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000235:genetics*
D001798:Blood Proteins