title: Substituted amylose as a matrix for sustained-drug release: a biodegradation study.
abstract: Substituted amylose polymers are prepared by reacting amylose chains with a suitable substituent such as 1,2-epoxypropanol (glycidol). Substituted amylose polymers are introduced as novel excipients for controlled release of bioactive materials. Since substituted amylose polymers are amylose-based polymers, they are subject to biodegradation by alpha-amylase enzymes present in the gastro-intestinal tract; thus, gamma spectroscopy is used to follow the release of the natural abundant rhenium (VII) oxide used as a drug model, and to test their resistance to alpha-amylase enzymatic degradation. Two substituted amylose solid dosage forms were prepared: (i) matrix system and (ii) dry-coated tablets. Matrix systems and dry-coated tablets maintained their structure, and controlled the release of [186Re] showing no significant degradation of tablets by alpha-amylase.
authors: Faculty of Pharmacy, University of Montreal, P.C. 6128, Station Centre-Ville, Quebec, H3C 3J7, Montreal, Canada.
authors: C
authors: C
authors: Chebli
authors: L
authors: L
authors: Cartilier
authors: N G
authors: NG
authors: Hartman
mesh_terms: D000688:Amylose / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D011108:Polymers; D013051:Spectrometry, Gamma; D013607:Tablets
chemical_list: D003692:Delayed-Action Preparations; D011108:Polymers; D013607:Tablets; D000688:Amylose