Biotin labelling of amines by polymer-assisted solution-phase synthesis.
An efficient and simple polymer-assisted approach has been developed to biotinylate multifunctional compounds bearing an amino functionality. Biotin was immobilized on aminomethylated polystyrene via the Kenner safety catch linker, activated and subsequently transferred to the amino function of the target compounds chemoselectively, thus avoiding protecting group operations. This approach holds potential for the introduction of spacer-modified biotin derivatives.
Golisade
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Universität Hamburg, Institut für Pharmazie, Bundesstrasse 45, D-20146, Hamburg, Germany.
Herforth
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Wieking
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Kunick
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C
Link
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D000588:Amines / Q000138:chemical synthesis* / Q000737:chemistry*; D001710:Biotin / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D011108:Polymers; D012996:Solutions
D000588:Amines; D011108:Polymers; D012996:Solutions; D001710:Biotin