title: Interaction of disintegrins with human neutrophils induces cytoskeleton reorganization, focal adhesion kinase activation, and extracellular-regulated kinase-2 nuclear translocation, interfering with the chemotactic function.
authors: Departamento de Farmacologia, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Brazil.
authors: A L
authors: AL
authors: Coelho
authors: M S
authors: MS
authors: De Freitas
authors: A
authors: A
authors: Mariano-Oliveira
authors: A L
authors: AL
authors: Oliveira-Carvalho
authors: R B
authors: RB
authors: Zingali
authors: C
authors: C
authors: Barja-Fidalgo
mesh_terms: D000199:Actins / Q000502:physiology; D021581:Active Transport, Cell Nucleus / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects* / Q000502:physiology; D003599:Cytoskeleton / Q000187:drug effects* / Q000502:physiology; D019483:Disintegrins / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D066298:In Vitro Techniques; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction
chemical_list: D000199:Actins; D019483:Disintegrins; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D020928:Mitogen-Activated Protein Kinases