title: Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion.
abstract: The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion, neurons in the piriform cortex began to be positively stained at 1 h, while neurons in the cortex and caudate of the MCA territory became positive after 8 h. The stainings persisted for 1 and 3 days after reperfusion. The present results indicate that neurons in the cerebral cortex and caudate have the capability of plastic change in the adult brain, and that those in the piriform cortex rapidly undergo plastic change probably in response to transneuronal injury.
authors: Department of Neurology, Okayama University Medical School, 2-5-1 Shikata-machi, 700-8558, Okayama, Japan. htakeshi@stanford.edu
authors: T
authors: T
authors: Hayashi
authors: T
authors: T
authors: Seki
authors: K
authors: K
authors: Sato
authors: M
authors: M
authors: Iwai
authors: W R
authors: WR
authors: Zhang
authors: Y
authors: Y
authors: Manabe
authors: K
authors: K
authors: Abe
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002455:Cell Division; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D005786:Gene Expression Regulation; D007124:Immunoenzyme Techniques; D020244:Infarction, Middle Cerebral Artery / Q000235:genetics / Q000378:metabolism*; D002546:Ischemic Attack, Transient / Q000235:genetics / Q000378:metabolism*; D008297:Male; D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules / Q000096:biosynthesis* / Q000235:genetics; D009473:Neuronal Plasticity / Q000235:genetics; D009474:Neurons / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000235:genetics / Q000378:metabolism; D012794:Sialic Acids / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D039842:Neural Cell Adhesion Molecule L1; D019006:Neural Cell Adhesion Molecules; D012794:Sialic Acids; C103469:polysialyl neural cell adhesion molecule