Prediction of presence and absence of two- and three-amino-acid sequences of human monoamine oxidase from its amino acid composition according to the random mechanism.
Three probabilistic procedures are used to analyse the human monoamine oxidase B (MAO-B). (1) Each kind of two-, three- and multi-amino-acid sequences is counted along MAO-B from one terminal to the other and their frequencies and probabilities are calculated. (2) The amino-acid sequences in MAO-B are compared with the theoretical amino-acid sequences and the present or absent theoretical amino-acid sequences in MAO-B are determined. (3) The random principle is used to predict the frequencies of presence and absence of amino-acid sequences in MAO-B from its amino acid composition and the comparison is made between predicted and counted frequencies. The results show the random principle can predict the presence of 99 two-amino-acid sequences in MAO-B and the absence of 38 and 7506 kinds of theoretical two- and three-amino-acid sequences from MAO-B.
Wu
G
G
Laboratoire de Toxicocinétique et Pharmacocinétique, Faculté de Pharmacie, Université de la Méditerranée Aix-Marseille II, Marseille, France. guang.wu@pharma.novartis.com
Yan
S
S
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D020134:Catalytic Domain; D019143:Evolution, Molecular; D006801:Humans; D015233:Models, Statistical; D008969:Molecular Sequence Data; D008995:Monoamine Oxidase / Q000737:chemistry*; D020539:Sequence Analysis, Protein / Q000379:methods*
D000596:Amino Acids; D008995:Monoamine Oxidase