Fluoxetine treatment of cocaine-dependent patients with major depressive disorder.
Sixty-eight male and female individuals with both DSM-IV diagnoses of cocaine dependence and major depressive disorder were randomly assigned to one of two medication conditions (placebo vs. 40 mg per day) as part of a double-blind, placebo-controlled clinical efficacy trial of fluoxetine for the treatment of this dual diagnosis. During the 12-week outpatient treatment phase all participants also received individual cognitive-behavioral psychotherapy targeting both cocaine use and depression. Depressive symptoms remitted as a function of time in treatment, with no significant medication effects found. Fewer cocaine positive urines were found during the first 6 weeks of treatment in the placebo group compared with the 40-mg group. Cocaine use and depressive symptoms during treatment were significantly correlated. The findings fail to support the role of fluoxetine for treatment of cocaine use and depression in dually-diagnosed patients.
Schmitz
J M
JM
Department of Psychiatry and Behavioral Sciences, Substance Abuse Research Center, University of Texas Medical School Houston, Houston, TX 77030, USA. joy.m.schmitz@uth.tmc.edu
Averill
P
P
Stotts
A L
AL
Moeller
F G
FG
Rhoades
H M
HM
Grabowski
J
J
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D019970:Cocaine-Related Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D003865:Major Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D005473:Fluoxetine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011379:Prognosis; D011613:Psychotherapy
D005473:Fluoxetine