Effect of xymedon on cell survival in the system sensory neuron Schwann cell.
Pyrimidine derivative xymedon inhibits neuronal death in L4-L5 spinal ganglia 30 days after ligation of rat sciatic nerve. After treatment with xymedon the number of neurons on the operated side decreased by 22.1% compared to that on the contralateral side, while in the control group this parameter decreased by 28.7%. At the same terms, the number of Schwann cells on the operated side after xymedon injection increased by 27.7% in comparison with that on the contralateral side, while in the control group this parameter decreased by 57.3%.
Raginov
I S
IS
Chelyshev
Y A
YA
Shagidullin
T F
TF
D000818:Animals; D002470:Cell Survival / Q000187:drug effects*; D007150:Immunohistochemistry; D008297:Male; D009475:Neurons, Afferent / Q000166:cytology / Q000187:drug effects*; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D012583:Schwann Cells / Q000166:cytology / Q000187:drug effects*; D012584:Sciatic Nerve / Q000293:injuries
D011743:Pyrimidines; C069705:xymedon