title: Phenylcyanoguanidines as inhibitors of glucose-induced insulin secretion from beta cells.
abstract: 3,5-Disubstituted-phenylcyanoguanidines have been identified as activators of SUR1/Kir6.2 potassium channels and as potent inhibitors of insulin release from pancreatic beta cells in vitro.
authors: Discovery and Development, Novo Nordisk A/S, Novo Nordisk Park, DK-2760, Måløv, Denmark.
authors: T M
authors: TM
authors: Tagmose
authors: J P
authors: JP
authors: Mogensen
authors: P C
authors: PC
authors: Agerholm
authors: P O
authors: PO
authors: Arkhammar
authors: P
authors: P
authors: Wahl
authors: A
authors: A
authors: Worsaae
authors: J B
authors: JB
authors: Hansen
mesh_terms: D002460:Cell Line; D005947:Glucose / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D007329:Insulin Antagonists / Q000494:pharmacology*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism
chemical_list: D006146:Guanidines; D007328:Insulin; D007329:Insulin Antagonists; D005947:Glucose