[Effect of four mutations (Cr,S,S(H),h) in genes for mink coat color on brain monoamine oxidase].
Activity of A and B types of monoamine oxidase (MAO) has been investigated in the brain stem and brain hemispheres of mink males of five genotypes for coat-color mutations: standard dark-brown (+/+); heterozygous for the semidominant mutation Black crystal (Cr/+); homozygous for the semidominant mutation Black cross, or "95% White" (S/S); heterozygous for the semidominant mutation Shadow (SH/+); and homozygous for the semirecessive mutation hedlum white (h/h). The main changes in the activity of the A and B MAO types occur in the brain hemispheres. A reduced activity of MAO A has been recorded in the hemispheres of Black crystal minks (Cr/+) and an elevated activity, in the hemispheres of Shadow (SH/+) and 95% White (S/S). The activity of MAO B is reduced in the hemispheres of Black crystal and elevated in the hemispheres of hedlum white (h/h). An increased MAO A activity has also been recorded in the brain stem of Shadow minks (SH/+). It is suggested that genes controlling coat color have a pleiotropic effect on sexual behavior in males and the endocrine function of testicles mediated by a putative change in the metabolism of brain neurotransmitters, substrates of MAOs A and B.
Voĭtenko
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NN
Institute of Cytology and Genetics, Siberian Division, Russian Academy of Sciences, Novosibirsk, 630090 Russia. npopova@bionet.nsc.ru
Trapezov
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OV
D000818:Animals; D001921:Brain / Q000201:enzymology*; D005838:Genotype; D006200:Hair Color / Q000235:genetics*; D008297:Male; D008907:Mink; D008995:Monoamine Oxidase / Q000378:metabolism*; D009154:Mutation; D012726:Sexual Behavior, Animal; D013737:Testis / Q000502:physiology
D008995:Monoamine Oxidase