XIAP, the guardian angel.
Controlling the activity of caspases is essential for the appropriate execution of cell death and the regulation of cell survival. One cellular inhibitor of apoptosis, XIAP, has emerged as a crucial regulator of caspases, and is itself subject to complex negative regulation.
Holcik
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Children's Hospital of Eastern Ontario Research Institute, and AEgera Oncology Inc., 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada. martin@mgcheo.med.uottawa.ca
Korneluk
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RG
D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000737:chemistry / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D051636:X-Linked Inhibitor of Apoptosis Protein
D004791:Enzyme Inhibitors; D011506:Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human; D020169:Caspases