title: Three new peroxides from the sponge Plakinastrella species.
abstract: Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide-lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 micrograms/mL (SDB) and 3.1 micrograms/mL (RPMI) for 3, and 25 micrograms/mL (SDB) and 6.25 micrograms/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 micrograms/mL.
authors: Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, Florida 34946, USA.
authors: Y
authors: Y
authors: Chen
authors: K B
authors: KB
authors: Killday
authors: P J
authors: PJ
authors: McCarthy
authors: R
authors: R
authors: Schimoler
authors: K
authors: K
authors: Chilson
authors: C
authors: C
authors: Selitrennikoff
authors: S A
authors: SA
authors: Pomponi
authors: A E
authors: AE
authors: Wright
mesh_terms: D000818:Animals; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*
chemical_list: D010545:Peroxides; C433591:epiplakinic acid F; C433590:plakinic acid F; C433592:plakortolide F