Studies on the oestrogenic activity of soybean oil on albino rats.
The oestrogenic activity of soybean oil was studied biologically by vaginal epithelium cornification and the uterine weight method. A significant increase in vaginal cornification was found in ovariectomized adult rats given soybean oil orally for five days resulting an oestrogenic like activity for the soybean oil. Also, using the uterine weight method in immature and ovariectomized rats, the administration of either oestradiol or soybean oil induced a significant increase in the uterine weight. These results indicated that the effect of soybean oil has an oestrogenic like activity equal to 0.6 that activity of oestradiol. Furthermore, with respect to body weight the administration of either oestradiol or soybean oil showed insignificant change than the initial body weight. These findings suggest that soybean oil exerts an oestrogenic like effect.
elSattar ElBaltran
S A
SA
Department of Pharmacology, National Research Center, Dokki, Giza, Egypt.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology; D004968:Estrogens, Non-Steroidal / Q000494:pharmacology*; D005260:Female; D007529:Isoflavones; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D048789:Phytoestrogens; D028321:Plant Preparations; D051381:Rats; D013024:Soybean Oil / Q000494:pharmacology*
D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D004958:Estradiol; D013024:Soybean Oil