title: [Sarcoidosis and progressive multifocal leukoencephalopathy].
abstract: A 70-year-old woman treated for sarcoidosis complained of progressive cognitive impairment and gait disability. Magnetic resonance imaging of the brain revealed a nonenhancing lesion in T1-weighted imaging in the left parieto-occipital region and sarcoidosis of the central nervous system was evoked. However, she rapidly deteriorated with posterior and cerebellar extension of the lesions, suggesting of progressive multifocal leukoencephalopathy (PML). DNA of the JC virus (JCV) was detected in the cerebrospinal fluid (CSF) by a polymerase chain reaction. Despite antiviral therapy, she died nine months after the first neurological signs. This case illustrates the possible association between sarcoidosis and PML, and underlines the interest to detect the presence of JCV in the CSF when the diagnosis of neurosarcoidosis appeared uncertain.
authors: Clinique Neurologique, Hôpital Roger Salengro, CHRU Lille, 59037 Lille cedex.
authors: M A
authors: MA
authors: Mackowiak-Cordoliani
authors: J
authors: J
authors: De Seze
authors: T
authors: T
authors: Stojkovic
authors: D
authors: D
authors: Ferriby
authors: D
authors: D
authors: Ingrand
authors: P
authors: P
authors: Vermersch
mesh_terms: D000368:Aged; D000998:Antiviral Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000150:complications* / Q000175:diagnosis; D002531:Cerebellum / Q000473:pathology; D003072:Cognition Disorders / Q000175:diagnosis / Q000209:etiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007968:Leukoencephalopathy, Progressive Multifocal / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000627:therapeutic use; D009483:Neuropsychological Tests; D009778:Occipital Lobe / Q000473:pathology; D030361:Papillomavirus Infections / Q000134:cerebrospinal fluid / Q000150:complications / Q000188:drug therapy; D010296:Parietal Lobe / Q000473:pathology; D012507:Sarcoidosis / Q000150:complications* / Q000175:diagnosis; D012720:Severity of Illness Index
chemical_list: D000998:Antiviral Agents; D007166:Immunosuppressive Agents; D008727:Methotrexate