Coordination between transcription and pre-mRNA processing.
A large body of work has proved that transcription by RNA polymerase II and pre-mRNA processing are coordinated events within the cell nucleus. Capping, splicing and polyadenylation occur while transcription proceeds, suggesting that RNA polymerase II plays a role in the regulation of these events. The presence and degree of phosphorylation of the carboxy-terminal domain of RNA polymerase II large subunit is important for functioning of the capping enzymes, the assembly of spliceosomes and the binding of the cleavage/polyadenylation complex. Nuclear architecture and gene promoter structure have also been shown to play key roles in coupling between transcription and splicing.
Cramer
P
P
Laboratorio de Fisiología y Biología Molecular, Departamento de Ciencias Biológicas, Universidad de Buenos Aires, Ciudad Universitaria, Argentina.
Srebrow
A
A
Kadener
S
S
Werbajh
S
S
de la Mata
M
M
Melen
G
G
Nogués
G
G
Kornblihtt
A R
AR
D006801:Humans; D046911:Macromolecular Substances; D008954:Models, Biological; D012319:RNA Polymerase II / Q000235:genetics / Q000378:metabolism*; D012322:RNA Precursors / Q000378:metabolism*; D012323:RNA Processing, Post-Transcriptional / Q000235:genetics*; D012326:RNA Splicing; D014158:Transcription, Genetic / Q000235:genetics / Q000502:physiology*
D046911:Macromolecular Substances; D012322:RNA Precursors; D012319:RNA Polymerase II