Mammalian histone acetyltransferases and their complexes.
One of the key questions in the current molecular genetics of eukaryotes is how genetic information is retrieved from tightly packed chromatin. Acetylation of core histone N-termini is implicated in the regulation of chromatin function, and I summarize what is known about the mammalian enzymes that promote this posttranslational histone modification. Chromatin is important in gene expression not only because of the accessibility problem that it poses for the transcriptional machinery but also with regard to the phenomenon of chromatin memory, i.e. the ability of alternative chromatin states to be maintained through many cell divisions. This phenomenon is believed to be central to epigenetic inheritance, an important concept in developmental biology, which is also emerging as a contributing factor in cancer and other health disorders. Analyses of the composition of large multiprotein acetyltransferase complexes suggest their role in the mechanisms of epigenetic inheritance. The review will discuss some models pertinent to this function of histone acetyltransferases.
Ogryzko
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VV
Laboratoire Oncogenese, Differenciation et Transduction du Signal, CNRS UPR 9079, Institut André Lwoff, Villejuif, France. v.ogryzko@vjf.cnrs.fr
D000123:Acetyltransferases / Q000737:chemistry / Q000378:metabolism*; D000818:Animals; D002843:Chromatin / Q000737:chemistry* / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation; D051548:Histone Acetyltransferases; D006657:Histones / Q000378:metabolism; D006801:Humans; D000074443:Lysine Acetyltransferase 5; D046911:Macromolecular Substances; D008957:Models, Genetic; D029701:Saccharomyces cerevisiae Proteins; D013379:Substrate Specificity; D019474:Transcription Factors, TFIII / Q000378:metabolism; D000098832:Transcription Factor TFIIIC
D002843:Chromatin; D006657:Histones; D046911:Macromolecular Substances; D029701:Saccharomyces cerevisiae Proteins; D019474:Transcription Factors, TFIII; D000098832:Transcription Factor TFIIIC; D000123:Acetyltransferases; D051548:Histone Acetyltransferases; C098489:KAT5 protein, human; D000074443:Lysine Acetyltransferase 5