[Prognostication of obstructive syndrome in patients with chronic bronchitis considering hereditary factors].
OBJECTIVE
To propose method of accurate prediction of chronic obstructive pulmonary disease (COPD) at early stages of development.


METHODS
92 males with COPD and 55 males with chronic non-obstructive bronchitis aged 38 to 72 years were examined according to a technique which identifies hereditary predisposition to multifactor diseases and using an algorithm based on multivariate analysis.


RESULTS
An original mathematical model is proposed which can quantitatively examine and range by influence the role of environmental and hereditary factors in development of COPD.


CONCLUSIONS
Detection of hereditary predisposition to COPD may be one of the objective criteria to recommend giving up smoking and for occupational orientation.
Ivchik
T V
TV
Kokosov
A N
AN
Razorenov
G I
GI
Razorenova
T S
TS
Iakovleva
N G
NG
D000328:Adult; D000368:Aged; D000465:Algorithms; D001991:Bronchitis / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D002908:Chronic Disease; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D015999:Multivariate Analysis; D011379:Prognosis
D005819:Genetic Markers