Kainate receptors: knocking out plasticity.
There is increasing evidence that kainate receptors contribute to both postsynaptic and presynaptic signaling. Studies of knockout mice have played a pivotal role in defining the functions of kainate receptors, including a recent study that implicates kainate receptors in frequency-dependent facilitation and long-term potentiation of hippocampal mossy fiber synapses.
Huettner
J E
JE
Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA. huettner@cellbio.wustl.edu [corrected]
D000818:Animals; D007546:Isoquinolines / Q000494:pharmacology; D017774:Long-Term Potentiation / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D019599:Mossy Fibers, Hippocampal / Q000187:drug effects / Q000502:physiology*; D012333:RNA, Messenger / Q000187:drug effects / Q000378:metabolism; D018092:Kainic Acid Receptors / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000187:drug effects / Q000502:physiology*; D000097806:GluK2 Kainate Receptor
D007546:Isoquinolines; D012333:RNA, Messenger; D018092:Kainic Acid Receptors; D000097806:GluK2 Kainate Receptor; C400802:LY382884