Enantiopure 2,3-dihydro-4-pyridones as synthetic intermediates: a concise asymmetric synthesis of (+)-allopumiliotoxin 267A.
[figure: see text] A concise asymmetric synthesis of (+)-allopumillotoxin 267A has been accomplished using an enantiopure dihydropyridone building block. The synthesis is highly stereoselective and requires 10 steps from readily available material.
Comins
D L
DL
Department of Chemistry, North Carolina State University, Raleigh, North Carolina 27695-8204, USA. daniel_comins@ncsu.edu
Huang
S
S
McArdle
C L
CL
Ingalls
C L
CL
D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D001001:Anura; D007212:Indolizines; D010880:Piperidines; D011728:Pyridones / Q000737:chemistry*; D013237:Stereoisomerism
D000470:Alkaloids; D007212:Indolizines; D010880:Piperidines; D011728:Pyridones; C431592:allopumiliotoxin 267A; C035482:pumiliotoxin A