title: Possible role of adjunctive thalidomide therapy in the resolution of a massive intracranial tuberculous abscess.
abstract: We present the case of a young child who developed a massive tuberculous abscess of the posterior fossa while being treated for pulmonary tuberculosis. Clinical improvement after surgical excision of the abscess was followed by recurrence of symptoms of acutely raised intracranial pressure on standard antituberculosis and corticosteroid therapy. Magnetic resonance (MR) imaging of the brain showed that a multiloculated abscess had developed anterior to the excision site of the original abscess. The recurring abscess was partly excised and drained but could not be removed completely because of its proximity to the brain stem. Thalidomide, a potent inhibitor of tumour necrosis factor alpha (TNF-alpha), was added to the treatment regimen and resulted in marked clinical improvement with resolution of the abscess within 4 months. The remaining CT lesion had the appearance of a small granuloma. Both the clinical and the radiological response was maintained after 1 year of antituberculosis treatment.
authors: Department of Paediatrics and Child Health, Tygerberg Hospital and University of Stellenbosch, Cape Town, South Africa. jfs@gerga.sun.ac.za
authors: J F
authors: JF
authors: Schoeman
authors: A
authors: A
authors: Ravenscroft
authors: H B
authors: HB
authors: Hartzenberg
mesh_terms: D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D012008:Recurrence; D012086:Reoperation; D013792:Thalidomide / Q000008:administration & dosage* / Q000009:adverse effects; D016862:Tuberculoma, Intracranial / Q000175:diagnosis / Q000188:drug therapy* / Q000601:surgery; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D000995:Antitubercular Agents; D014409:Tumor Necrosis Factor-alpha; D013792:Thalidomide