[QTc interval in newborns with gastroesophageal reflux treated with cisapride and ranitidine].
Gastroesophageal reflux (GER) is very common in infants, especially in prematures and may be cause of gastrointestinal and cardiorespiratory symptoms. Cisapride, a prokinetic agent, is used in order to avoid the transient esophageal sphincter relaxation, but it is sometimes associated to transient prolongation of QT interval on EKG, especially with high dosage. The authors report the effects of cisapride therapy (0.8 mg/Kg/day) on QTc interval (QTc = QT interval corrected on heart frequency) in a pediatric population (50 infants) with GER. Results demonstrate the relatively safety of cisapride therapy at low dose also in the pediatric period.
Lista
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U.O di Terapia Intensiva Neonatale, Ospedale Buzzi, ICP Milano, Italia.
Maestri
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L
Meroni
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M
Massari
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D
Colli
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A
Porcelli
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F
Menchini
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M
Introvini
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P
Compagnoni
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G
D020117:Cisapride / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects*; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology*; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D011899:Ranitidine / Q000627:therapeutic use*
D005765:Gastrointestinal Agents; D011899:Ranitidine; D020117:Cisapride