Immunohistochemical study of angiotensin receptors in normal human sweat glands and eccrine poroma.
BACKGROUND
Angiotensin II exerts its actions through its specific receptors. However, expression of these receptors has not been determined in sweat glands.


OBJECTIVE
To clarify the expression and localization of the angiotensin receptors in normal human sweat glands and eccrine poroma.


METHODS
Expression of angiotensin type 1 (AT1) and type 2 (AT2) receptors in normal human eccrine and apocrine sweat glands and 12 cases of eccrine poroma was studied using immunohistochemistry.


RESULTS
In eccrine sweat glands, the acrosyringium and the inner surfaces and luminal cells of the intradermal duct showed positive staining with AT1. In apocrine sweat glands, the intraepithelial duct and luminal cells of the intradermal duct showed positive staining with AT1. In 12 cases of eccrine poroma, some of the tumour cells in the tumour strands and cells surrounding the luminal structures stained positively. There were no positive findings with AT2.


CONCLUSIONS
Studying AT1 distribution may be useful in understanding the pathophysiology of sweat glands and sweat gland tumours.
Takeda
H
H
Department of Dermatology, Yamagata University School of Medicine, 2-2-2 Iida-Nishi, Yamagata 990-9585, Japan. hitakeda@med.id.yamagata-u.ac.jp
Kondo
S
S
D018250:Acrospiroma / Q000378:metabolism*; D000328:Adult; D000804:Angiotensin II / Q000378:metabolism*; D001050:Apocrine Glands / Q000378:metabolism; D004439:Eccrine Glands / Q000378:metabolism; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009363:Neoplasm Proteins / Q000378:metabolism; D011945:Receptors, Angiotensin / Q000378:metabolism*; D013544:Sweat Gland Neoplasms / Q000378:metabolism*; D013545:Sweat Glands / Q000378:metabolism*
D009363:Neoplasm Proteins; D011945:Receptors, Angiotensin; D000804:Angiotensin II