[Hematopoietic allogeneic transplantation with attenuated conditioning regimen on an outpatient basis. First experience in Spain].
BACKGROUND
Allogeneic hematopoietic transplantation using attenuated conditioning regimens seems promising. This procedure associates to relatively low morbidity and mortality. In consequence, an outpatient management of this transplantation modality may be considered, even in elderly patients.
This approach was considered in a 62 years-old female suffering from chronic myeloid leukemia in chronic phase. The conditioning regimen included fludarabine and 200 cGy of total body irradiation. Cyclosporine A and mycophenolate mofetil were used as immunosuppression. Conditioning, peripheral-blood stem-cell infusion, and postransplant follow-up was managed in the outpatient setting. Two short admissions were required. Eight months after transplant, the patient remains in sustained haematological remission with complete donor chimerism,has a 100% Karnofsky score and continues being managed on an outpatient basis.


CONCLUSIONS
Allogeneic stem-cell transplantation can be performed safely on an outpatient basis,even in elderly patients.
Salar
A
A
Servicios de Hematología Clínica. Hospital de la Santa Creu i Sant Pau. Barcelona. asalar@hsp.santpau.es
Prats
M
M
Muñiz
E
E
Clopés
A
A
Martino
R
R
Brunet
S
S
Pero
A
A
Sierra
J
J
D000553:Ambulatory Care; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D015466:Leukemia, Myeloid, Chronic-Phase / Q000628:therapy; D008875:Middle Aged; D013030:Spain; D019172:Transplantation Conditioning; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation
D000970:Antineoplastic Agents; D007166:Immunosuppressive Agents