title: In vitro steady-flow analysis of systemic-to-pulmonary shunt haemodynamics.
abstract: A modified Blalock-Taussig shunt is a connection created between the systemic and pulmonary arterial circulations to improve pulmonary perfusion in children with congenital heart diseases. Survival of these patients is critically dependent on blood flow distribution between the pulmonary and systemic circulations which in turn depends upon the flow resistance of the shunt. Previously, we investigated the pressure-flow relationship in rigid shunts with a computational approach. to estimate the pulmonary blood flow rate on the basis of the in vivo measured pressure drop. The present study aims at evaluating, in vitro how the anastomotic distensibility and restrictions due to suture presence affect the shunt pressure-flow relationship. Two actual Gore-Tex shunts (3 and 4 mm diameters) were sutured to compliant conduits by a surgeon and tested at different steady flow rates (0.25-11 min(-1)) and pulmonary pressures (3-34 mmHg). Corresponding computational models were also created to investigate the role of the anastomotic restrictions due to sutures. In vitro experiments showed that pulmonary artery pressure affects the pressure-flow relationship of the anastomoses. particularly at the distal site. However, this occurrence scarcely influences the total shunt pressure drop. Comparisons between in vitro and computational models without anastomotic restrictions show that the latter underestimates the in vitro pressure drops at any flow rate. The addition of the anastomotic restrictions (31 and 47% of the original area of 3 and 4 mm shunts, respectively) to the computational models reduces the gap, especially at high shunt flow rate and high pulmonary pressure.
authors: Department of Bioengineering, Politecnico di Milano, Italy.
authors: G
authors: G
authors: Pennati
authors: G B
authors: GB
authors: Fiore
authors: F
authors: F
authors: Migliavacca
authors: K
authors: K
authors: Laganà
authors: R
authors: R
authors: Fumero
authors: G
authors: G
authors: Dubini
mesh_terms: D000714:Anastomosis, Surgical; D001794:Blood Pressure; D006439:Hemodynamics; D006706:Homeostasis; D006801:Humans; D008955:Models, Cardiovascular; D011138:Polytetrafluoroethylene; D011652:Pulmonary Circulation / Q000502:physiology*; D013537:Sutures; D014656:Vascular Surgical Procedures; D014666:Vasomotor System / Q000502:physiology
chemical_list: D011138:Polytetrafluoroethylene