Genetic linkage analysis of the antibody responses to myelin basic protein and myelin oligodendrocyte glycoprotein in rats immunized with rat spinal cord homogenate.
The genetic control of the antibody response to myelin basic protein (MBP) and myelin oligodendrocyte glycoprotein (MOG) was analysed in F1 and F2 crosses of DA and E3 rats, immunized with rat spinal chord homogenate. The DA rats were highly susceptible to encephalomyelitis and made antibody responses to both MBP and MOG, whereas the E3 rats were disease-resistant and responded only to MOG. The anti-MBP response was mainly controlled by the disease-promoting MHC region of the DA strain together with several disease loci outside MHC. In contrast, the anti-MOG response was associated with loci not related to or actually conferring resistance to disease.
Yang
H T
HT
Department of Genetics and Pathology, Section of Medical Genetics, Rudbeck Laboratory, Uppsala University, S-751 85, Uppsala, Sweden.
Bergsteinsdottir
K
K
Wernhoff
P
P
Linington
C
C
Pettersson
U
U
Holmdahl
R
R
D000818:Animals; D000917:Antibody Formation; D005260:Female; D008040:Genetic Linkage; D007114:Immunization; D008285:Major Histocompatibility Complex / Q000502:physiology; D008297:Male; D004676:Myelin Basic Protein / Q000276:immunology*; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D063308:Myelin-Oligodendrocyte Glycoprotein; D051381:Rats; D013116:Spinal Cord / Q000276:immunology*
C571328:Mog protein, rat; D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein