Linking class-switch recombination with somatic hypermutation.
The recent discovery of a molecular link between two apparently different genetic alteration events--class-switch recombination and somatic hypermutation--has led to the idea that the recognition and cleavage of target DNA in these two events might be mediated by similar or identical molecules to those involved in RNA editing. This could mean that the complexity of mammalian genetic information may be enriched by an interplay between RNA editing and DNA modification.
Kinoshita
K
K
Department of Medical Chemistry and Molecular Biology, Graduate School of Medicine, Kyoto University, Yoshida Konoe-cho, Sakyo-Ku, Kyoto 606-8501, Japan.
Honjo
T
T
D000071479:APOBEC-1 Deaminase; D000818:Animals; D003564:Cytidine Deaminase / Q000235:genetics / Q000378:metabolism*; D004247:DNA / Q000378:metabolism; D017930:Genes, Reporter; D018858:Germinal Center / Q000276:immunology; D017578:Immunoglobulin Class Switching / Q000235:genetics*; D008957:Models, Genetic; D009154:Mutation; D009690:Nucleic Acid Conformation; D017393:RNA Editing; D011993:Recombinant Fusion Proteins / Q000378:metabolism; D011995:Recombination, Genetic; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
D011993:Recombinant Fusion Proteins; D004247:DNA; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D000071479:APOBEC-1 Deaminase; D003564:Cytidine Deaminase