title: Linear IgA bullous dermatosis responsive to a gluten-free diet.
abstract: Dermatitis herpetiformis is associated with a gluten-sensitive enteropathy in >85% of cases. Both the skin lesions and the enteropathy respond to gluten restriction. Linear IgA bullous dermatosis has a much lower prevalence of histological small bowel abnormalities, and lesions are not known to respond to gluten restriction. We report a patient with linear IgA bullous dermatosis and gluten-sensitive enteropathy. This report addresses the issue of whether linear IgA bullous dermatosis can be associated with gluten-sensitive enteropathy. We evaluated the response to gluten restriction and normal diet by following the status of the patient's jejunal biopsies and skin lesions. The patient responded to gluten restriction, as shown by resolution of jejunal abnormalities and skin lesions and subsequently by recurrence of jejunal abnormalities and skin lesions with reinstitution of a gluten-containing diet. This report demonstrates that linear IgA bullous dermatosis can respond to gluten restriction if an underlying gluten-sensitive enteropathy is present.
authors: Geriatric Research, Education and Clinical Center, Veterans Affairs Medical Center, Salt Lake City, Utah, USA.
authors: C A
authors: CA
authors: Egan
authors: E P
authors: EP
authors: Smith
authors: T B
authors: TB
authors: Taylor
authors: L J
authors: LJ
authors: Meyer
authors: W S
authors: WS
authors: Samowitz
authors: J J
authors: JJ
authors: Zone
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000209:etiology* / Q000473:pathology; D005260:Female; D005512:Food Hypersensitivity / Q000150:complications*; D005983:Glutens / Q000009:adverse effects*; D006801:Humans; D007070:Immunoglobulin A; D007583:Jejunum / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000150:complications / Q000188:drug therapy* / Q000276:immunology
chemical_list: D007070:Immunoglobulin A; D005983:Glutens