Antifungal activity of modified hederagenin glycosides from the leaves of Kalopanax pictum var. chinense.
Monodesmosides which were obtained from the partial degradation of hederagenin bisdesmosides exhibited significant antifungal effect against Microsporum canis, Coccidioides immitis, Trichophyton mentagrophytes, Cryptococcus neoformans, and Candida albicans at the minimal inhibitory concentrations of 6.25-25 microg/ml. The hederagenin glycosides were isolated from the leaves of Kalopanax pictum var. chinense.
Lee
M W
MW
College of Pharmacy, Chung Ang University, Seoul, Korea. mwlee@cau.ac.kr
Kim
S U
SU
Hahn
D R
DR
D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D005658:Fungi / Q000145:classification / Q000187:drug effects*; D006027:Glycosides / Q000737:chemistry / Q000494:pharmacology*; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D018515:Plant Leaves / Q000737:chemistry
D000935:Antifungal Agents; D006027:Glycosides; D009828:Oleanolic Acid; C025763:hederagenin