title: ICOS costimulation: It's not just for TH2 cells anymore.
abstract: A current paradigm has ICOS participating in TH2 costimulation. New data indicates ICOS regulates not only TH2 cells, but also TH1s.
authors: Section of Pulmonary and Critical Care Medicine, Department of Medicine, and the Committee on Immunology, University of Chicago, Chicago, IL 60637, USA. asperlin@medicine.bsd.uchicago.edu
authors: A I
authors: AI
authors: Sperling
authors: J A
authors: JA
authors: Bluestone
mesh_terms: D000069594:Abatacept; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000276:immunology; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D023201:CD40 Ligand / Q000276:immunology; D060908:CTLA-4 Antigen; D016207:Cytokines / Q000276:immunology; D004268:DNA-Binding Proteins / Q000276:immunology; D050990:GATA3 Transcription Factor; D016027:Heart Transplantation / Q000276:immunology; D018796:Immunoconjugates; D060889:Inducible T-Cell Co-Stimulator Protein; D008213:Lymphocyte Activation / Q000276:immunology; D011518:Proto-Oncogene Proteins / Q000276:immunology; D051257:Proto-Oncogene Proteins c-maf; D015398:Signal Transduction / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*; D015534:Trans-Activators / Q000276:immunology; D014184:Transplantation, Homologous / Q000276:immunology
chemical_list: D015703:Antigens, CD; D000943:Antigens, Differentiation; D000945:Antigens, Differentiation, T-Lymphocyte; D060908:CTLA-4 Antigen; D016207:Cytokines; D004268:DNA-Binding Proteins; D050990:GATA3 Transcription Factor; D018796:Immunoconjugates; D060889:Inducible T-Cell Co-Stimulator Protein; D011518:Proto-Oncogene Proteins; D051257:Proto-Oncogene Proteins c-maf; D015534:Trans-Activators; D023201:CD40 Ligand; D000069594:Abatacept