title: Solid-phase synthesis of beta-lactams via the Miller hydroxamate approach.
abstract: [figure: see text] beta-Lactams were prepared on solid phase starting from serine, threonine, or other beta-hydroxyacids derived from naturally occurring amino acids and a resin bound hydroxylamine. The ring closure was carried out under Mitsunobu conditions. The amino group present on the beta-lactam was used to assemble a short peptide. After a reductive cleavage with Sml2, beta-lactam-containing peptides were obtained.
authors: Dipartimento di Chimica, Università degli Studi di Sassari, Via Vienna 2, I-07100 Sassari, Italy.
authors: M M
authors: MM
authors: Meloni
authors: M
authors: M
authors: Taddei
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D006877:Hydroxamic Acids / Q000737:chemistry*; D006898:Hydroxylamines; D011137:Polystyrenes; D012694:Serine / Q000737:chemistry; D013912:Threonine / Q000737:chemistry; D047090:beta-Lactams / Q000138:chemical synthesis*
chemical_list: D000900:Anti-Bacterial Agents; D006877:Hydroxamic Acids; D006898:Hydroxylamines; D011137:Polystyrenes; D047090:beta-Lactams; D013912:Threonine; D012694:Serine