Absence of therapeutically relevant c-erbB-2 expression in human hepatocellular carcinomas.
c-erbB-2 (Her-2/neu) represents a well established prognostic marker and therapeutic target in several human tumor types, especially breast cancer. Its potential role in hepatocellular carcinoma (HCC) has not yet been characterized. Using standardized immunohistochemical procedures, we have analyzed the c-erbB-2 expression in a representative panel of human HCCs. Our data demonstrate the absence of significant membranous expression or cytoplasmic overexpression. Thus c-erbB-2 is neither a prognostic marker nor a relevant therapeutic target in human HCCs.
Prange
W
W
Institut fur Pathologie, Universitat zu Koln, Joseph-Stelzmann-Str. 9, D-50931 Koln, Germany.
Schirmacher
P
P
D014408:Biomarkers, Tumor / Q000378:metabolism*; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology; D006528:Carcinoma, Hepatocellular / Q000378:metabolism* / Q000473:pathology; D003593:Cytoplasm / Q000378:metabolism; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000378:metabolism*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases