The in vivo activity of olamufloxacin (HSR-903) in systemic and urinary tract infections in mice.
The in vivo activity of olamufloxacin (HSR-903), a new fluoroquinolone, was evaluated and compared with ciprofloxacin, sparfloxacin and levofloxacin. Olamufloxacin was active against systemic infection in mice inoculated with both Gram-positive and -negative bacteria. Olamufloxacin had equal efficacy for experimental urinary tract infections in mice caused by Pseudomonas aeruginosa.
Yoshizumi
S
S
Department of Microbiology, Toho University School of Medicine, Tokyo. Research Department, Research & Development Division, Hokuriku Seiyaku Co., Ltd, Fukui, Japan. satoshi.yoshizumi@hokuriku-seiyaku.co.jp
Takahashi
Y
Y
Murata
M
M
Domon
H
H
Furuya
N
N
Ishii
Y
Y
Matsumoto
T
T
Ohno
A
A
Tateda
K
K
Miyazaki
S
S
Yamaguchi
K
K
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D024841:Fluoroquinolones; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015363:Quinolones / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C106426:olamufloxacin