Up-regulation of E2F-1 in Down's syndrome brain exhibiting neuropathological features of Alzheimer-type dementia.
We studied the expression of the apoptosis-related protein, E2F-1, in Down's syndrome (DS) brains. The immunoreactivity for E2F-1 was detected in the pyramidal neurons of the cerebral cortex from DS brains exhibiting the neuropathological features of dementia of Alzheimer type (DAT), in accordance with the amyloid beta protein (A beta) deposition in the neuron. Therefore, the implication is that A beta deposition may trigger E2F-1-mediated neuronal apoptosis in DS brains with DAT.
Motonaga
K
K
Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, 4-1-1 Ogawahigashi, Kodaira, Tokyo 187-8502, Japan. motonaga@ncnp.go.jp
Itoh
M
M
Hirayama
A
A
Hirano
S
S
Becker
L E
LE
Goto
Y
Y
Takashima
S
S
D000293:Adolescent; D000328:Adult; D000544:Alzheimer Disease / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D016229:Amyloid beta-Peptides / Q000378:metabolism; D017209:Apoptosis / Q000235:genetics; D018797:Cell Cycle Proteins; D002540:Cerebral Cortex / Q000378:metabolism / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D004268:DNA-Binding Proteins; D004314:Down Syndrome / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; D005333:Fetus; D006801:Humans; D007150:Immunohistochemistry; D007223:Infant; D007231:Infant, Newborn; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D008875:Middle Aged; D058225:Plaque, Amyloid / Q000378:metabolism / Q000473:pathology; D017966:Pyramidal Cells / Q000378:metabolism / Q000473:pathology; D014157:Transcription Factors / Q000378:metabolism*; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D015854:Up-Regulation / Q000235:genetics*
D016229:Amyloid beta-Peptides; D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D050687:E2F1 Transcription Factor; C493753:E2F1 protein, human; D008869:Microtubule-Associated Proteins; D014157:Transcription Factors; D016159:Tumor Suppressor Protein p53