Verbenachalcone, a novel dimeric dihydrochalcone with potentiating activity on nerve growth factor-action from Verbena littoralis.
A novel dimeric dihydrochalcone, verbenachalcone (1), was isolated from the aerial parts of Verbena littoralis. Its structure was elucidated, on the basis of spectral data interpretation, as 4,2',4',2' ",4' "-pentahydroxy-3' '-methoxy-3-O-4' '-tetrahydrobichalcone. This compound caused a significant enhancement of nerve growth factor-mediated neurite outgrowth from PC12D cells.
Li
Y S
YS
Department of Pharmaceutical Molecular Biology, Graduate School of Pharmaceutical Sciences, Tohoku University, Aoba, Aramaki, Aoba-ku, Sendai 980-8578, Japan.
Matsunaga
K
K
Kato
R
R
Ohizumi
Y
Y
D000818:Animals; D002478:Cells, Cultured; D002599:Chalcone / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology; D047188:Chalcones; D004357:Drug Synergism; D020932:Nerve Growth Factor / Q000494:pharmacology*; D016501:Neurites / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D010239:Paraguay; D010946:Plants, Medicinal / Q000737:chemistry*; D013055:Spectrophotometry, Infrared
D047188:Chalcones; C433608:verbenachalcone; D002599:Chalcone; D020932:Nerve Growth Factor