Assessing myocardial viability using the coronary flow response to intravenous dobutamine infusion in recent myocardial infarction.
Coronary flow response to low-dose (5 and 10 micrograms/kg/min) dobutamine infusion was used to assess myocardial viability at the time of cardiac catheterization in 13 patients (age, 60 +/- 11 years) with recent myocardial infarction. Echocardiographic improvement in regional wall motion performed 4 to 6 weeks after discharge was used as the marker for viability. Viable patients demonstrated a 2-fold increase in flow from baseline (p < 0.001) during intravenous infusion. In contrast, patients without viability demonstrated no increase in flow. The coronary flow response to dobutamine measured at the time of catheterization shows promise in identifying viable myocardium in postinfarction patients.
Rollefson
W A
WA
Department of Medicine, Cardiology Service, Brooke Army Medical Center, San Antonio, TX, USA.
Rubal
B J
BJ
Ebersole
D G
DG
Mego
D M
DM
Boyd
S Y
SY
Zimring
H J
HJ
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001783:Blood Flow Velocity; D002316:Cardiotonic Agents; D003326:Coronary Circulation; D004280:Dobutamine; D015150:Echocardiography, Doppler; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009203:Myocardial Infarction / Q000503:physiopathology*; D011379:Prognosis; D011877:Radionuclide Imaging
D002316:Cardiotonic Agents; D004280:Dobutamine