title: Wilson's disease presenting with rapidly progressive visual loss: another neurologic manifestation of Wilson's disease?
abstract: Wilson's disease (WD) is a rare autosomal recessive disorder of copper metabolism resulting in copper-induced tissue damage that primarily involves the liver and central nervous system. The neurologic manifestations of WD almost universally involve a derangement of basal ganglia function or psychiatric disturbance. We report the case of a 46-year-old man presenting with end-stage liver disease caused by WD who had associated rapidly progressive optic neuropathy. We also discuss the possible association between the two conditions.
authors: Department of Gastroenterology, John Radcliffe Hospital, Headington, Oxford, United Kingdom.
authors: P J
authors: PJ
authors: Gow
authors: S E
authors: SE
authors: Peacock
authors: R W
authors: RW
authors: Chapman
mesh_terms: D006527:Hepatolenticular Degeneration / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D017093:Liver Failure / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009901:Optic Nerve Diseases / Q000209:etiology*; D014786:Vision Disorders / Q000209:etiology