Hydrophilic hybrid IPNs of segmented polyurethanes and copolymers of vinylpyrrolidone for applications in medicine.
The preparation and biocompatibility properties of thermoplastic apparent interpenetrating polymer networks (T-IPNs) of a segmented polyurethaneurea, Biospan (BS), and vinylpyrrolidone-dimethylacrylamide (VP-DMAm) copolymers, are described. The biological interaction between the obtained materials and blood was studied by in vitro methods. The addition of the VP-DMAm copolymers to form T-IPNs with BS substantially increased the equilibrium water uptake and water diffusion coefficients. Investigation of the proteins adsorption, platelet adhesion, thrombus formation and factor XII activation is presented. Investigations of the proteins adsorption of the BS/VP-DMAm T-IPNs surfaces show that the segmented polyurethane (BS) containing VP-DMAm copolymers with higher VP content adsorb more albumin than fibrinogen and gamma-globulin. The platelets adhesion, thrombus formation and factor XII activation are effectively suppressed with respect to the segmented polyurethane when VP-DMAm copolymers with high VP contents are incorporated into BS as T-IPNs.
Abraham
G A
GA
Instituto de Ciencia y Tecnologia de Polimeros, CSIC, Madrid, Spain
de Queiroz
A A
AA
Román
J S
JS
D000327:Adsorption; D000418:Albumins / Q000737:chemistry; D001672:Biocompatible Materials / Q000737:chemistry* / Q000494:pharmacology; D001704:Biopolymers / Q000737:chemistry* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D002152:Calorimetry, Differential Scanning; D004058:Diffusion; D004789:Enzyme Activation / Q000187:drug effects; D005174:Factor XII / Q000378:metabolism; D005340:Fibrinogen / Q000737:chemistry; D006801:Humans; D008422:Materials Testing; D010973:Platelet Adhesiveness / Q000187:drug effects; D011140:Polyurethanes / Q000737:chemistry* / Q000494:pharmacology; D011145:Polyvinyls / Q000737:chemistry* / Q000494:pharmacology; D011760:Pyrrolidinones / Q000737:chemistry* / Q000494:pharmacology; D017550:Spectroscopy, Fourier Transform Infrared; D013499:Surface Properties; D014867:Water; D005719:gamma-Globulins / Q000737:chemistry
D000418:Albumins; D001672:Biocompatible Materials; D001704:Biopolymers; D011140:Polyurethanes; D011145:Polyvinyls; D011760:Pyrrolidinones; D005719:gamma-Globulins; C439609:poly(vinylpyrrolidinone-co-dimethyacrylamide); D014867:Water; D005174:Factor XII; D005340:Fibrinogen; C044690:polyetherurethane urea