My life and times with enzymes and mediators.
The vascular endothelium plays a vital role in the control of the circulation. It metabolises various vasoactive substances, converts angiotensin I to angiotensin II and secretes the potent vasodilator prostacyclin, as well as nitric oxide and endothelin-1. The balance between these mediators determines the response of the cardiovascular system in diseases such as hypertension, atherosclerosis and myocardial infarction. In this article I describe some of my work over the past 50 years. In the process, I hope to show that it is not only Princes who travel the road to Serendip but also Scientists. The application of simple methods, luck, happy coincidences, serendipity and noticing the unusual have all played an important role in my scientific career. However, the choice of colleagues has also been vital.
Vane
J R
JR
The William Harvey Research Foundation, The William Harvey Research Institute, London, UK. c.l.measures@mds.qmw.ac.uk
D000739:Anecdotes as Topic; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D004798:Enzymes; D011464:Epoprostenol / Q000096:biosynthesis / Q000502:physiology / Q000627:therapeutic use; D006801:Humans
D000806:Angiotensin-Converting Enzyme Inhibitors; D016861:Cyclooxygenase Inhibitors; D004798:Enzymes; D011464:Epoprostenol