The relationship of fasting plasma glucose values and other variables to 2-h postload plasma glucose in Japanese subjects.
OBJECTIVE
To investigate the relationship between fasting plasma glucose (FPG) values and other variables (e.g., age, sex, and BMI) to 2-h post-75-g oral glucose load glycemia (PG) in Japanese subjects.


METHODS
Subjects included 13,694 Japanese subjects between 20 and 83 years of age (10,677 men and 3,017 women) who were undergoing a 75-g oral glucose tolerance test (OGTT) during a health screening performed at our hospital. The influences of age for 2-h PG at a fixed fasting plasma glucose (FPG) level of 126 mg/dl were analyzed. Multiple linear regression analysis was performed using a model in which the dependent variable was 2-h PG using the following explanatory variables: FPG, age, sex, BMI, blood pressure, plasma cholesterol, and triglyceride (TG) levels.


RESULTS
The 2-h PG at a fixed FPG of 126 mg/dl increased by 0.94 mg/dl per year in patients aged between 30 and 78 years (r = 0.68, P < 0.0001). In multiple regression, five explanatory variables (FPG, age, BMI, plasma TG levels, and systolic blood pressure levels) were all positively associated with 2-h PG. The percentages of patients with 2-h diabetes (isolated postchallenge hyperglycemia [IPH]) versus fasting plus 2-h diabetes by the World Health Organization criteria significantly (P = 0.005) increased as the patients' decades increased, whereas the impact of BMI on the percentages was significant only in young patients (P = 0.001).


CONCLUSIONS
Aging was found to be the second best predictor of 2-h PG on multiple regression. Therefore, OGTT should be performed especially in elderly patients because they show IPH more frequently.
Bando
Y
Y
Department of Internal Medicine, Fukui-ken Saiseikai Hospital, Fukui, Japan. bando@po.incl.ne.jp
Ushiogi
Y
Y
Okafuji
K
K
Toya
D
D
Tanaka
N
N
Fujisawa
M
M
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D044466:Asian People; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism*; D015992:Body Mass Index; D005215:Fasting; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007564:Japan; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D012044:Regression Analysis; D012737:Sex Factors; D013599:Systole; D014280:Triglycerides / Q000097:blood; D014944:World Health Organization
D001786:Blood Glucose; D014280:Triglycerides