Anticonvulsant effects of new morphinan derivatives.
We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.
Kim
H C
HC
Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, 200-701, Chunchon, South Korea. kimhc@cc.kangwon.ac.kr
Nabeshima
T
T
Jhoo
W K
WK
Ko
K H
KH
Kim
W K
WK
Shin
E J
EJ
Cho
M
M
Lee
P H
PH
D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology*; D009019:Morphinans / Q000737:chemistry / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
D000927:Anticonvulsants; D009019:Morphinans