Hypercalcaemia associated with chronic lymphocytic leukaemia in a Giant Schnauzer.
A 7-year-old male Giant Schnauzer was referred with a history of severe vomiting, lethargy, weight loss, polydipsia and polyuria. Detailed investigations revealed leucocytosis with a marked lymphocytosis, mild non-regenerative anaemia, thrombocytopenia, hypercalcaemia and azotaemia. Circulating lymphocytes were small and well-differentiated, and the same lymphoid population was present in bone marrow. Chronic lymphocyctic leukaemia with associated paraneoplastic hypercalcaemia was diagnosed. Immunohistochemical staining of a bone marrow biopsy revealed a neoplastic B-cell line expressing CD79. The dog responded to therapy with prednisolone and chlorambucil for a period of 8 months.
Kleiter
M
M
I. Medical Clinic for Small Animals and Horses, University of Veterinary Medicine Vienna, Veterinaerplatz 1, 1210 Vienna, Austria.
Hirt
R
R
Kirtz
G
G
Day
M J
MJ
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D004283:Dog Diseases / Q000175:diagnosis* / Q000473:pathology; D004285:Dogs; D006934:Hypercalcemia / Q000473:pathology / Q000662:veterinary*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000662:veterinary*; D008297:Male; D011230:Precancerous Conditions / Q000473:pathology / Q000662:veterinary*