Analgesic effect of olipiphate on mouse model of chemical stimulation of peritoneum.
We studied the analgesic effect of olipiphate, a product of lignin, against writhing provoked by intraperitoneal injection of acetic acid. Paracetamol was used as the reference drug. Both agents dose-dependently decreased the number of motor reactions caused by the irritant. Olipiphate possessed analgesic activity and efficiency comparable with those of paracetamol, but produced a more long-lasting effect.
Zvartau
E E
EE
I. P. Pavlov Medical University, St. Petersburg. zvartau@spmu.rssi.ru
Patkina
N A
NA
Kashkin
V A
VA
Reztsova
V V
VV
Filov
V A
VA
D019342:Acetic Acid / Q000008:administration & dosage; D000700:Analgesics / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D008031:Lignin / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D051379:Mice; D023421:Models, Animal; D010146:Pain / Q000139:chemically induced / Q000188:drug therapy*; D010537:Peritoneum / Q000187:drug effects*
D000700:Analgesics; C413426:olipifat; D008031:Lignin; D019342:Acetic Acid