Cell-matrix interactions, alteration with aging and age associated diseases. A review.
Cell-matrix interactions are mediated by matrix components and cell surface receptors, among them integrins. During aging there are qualitative and quantitative alterations of matrix components. Similar modifications were observed with integrins. During diseases, some integrins appear to be differentially or ectopically expressed. Two examples are given showing the appearance of key receptors and the role of antagonists in their expression opening the field of therapeutic possibilities.
Labat-Robert
J
J
Laboratoire de recherches ophtalmologiques, université Paris 6, Hôtel-Dieu, 1, place du Parvis Notre-Dame, 75181 Paris, France.
D000375:Aging; D000818:Animals; D001161:Arteriosclerosis; D004194:Disease; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D005353:Fibronectins / Q000032:analysis / Q000235:genetics / Q000502:physiology; D006801:Humans; D016023:Integrins / Q000235:genetics / Q000502:physiology; D009369:Neoplasms; D018919:Neovascularization, Physiologic; D011956:Receptors, Cell Surface / Q000502:physiology*
D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D016023:Integrins; D011956:Receptors, Cell Surface