The mitochondrion in apoptosis: how Pandora's box opens.
There is widespread agreement that mitochondria have a function in apoptosis, but the mechanisms behind their involvement remain controversial. Here we suggest that opening of a multiprotein complex called the mitochondrial permeability transition pore complex is sufficient (and, usually, necessary) for triggering apoptosis.
Zamzami
N
N
Centre National de la Recherche Scientifique, UMR1599, Institut Gustave Roussy, 39 rue Camille-Desmoulins, F-94805 Villejuif, France.
Kroemer
G
G
D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D007425:Intracellular Membranes / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D000226:Mitochondrial ADP, ATP Translocases / Q000494:pharmacology; D008954:Models, Biological; D010539:Permeability; D018272:Porins / Q000502:physiology; D011518:Proto-Oncogene Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D050994:Voltage-Dependent Anion Channels; D051028:bcl-2-Associated X Protein
D018272:Porins; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D050994:Voltage-Dependent Anion Channels; D051028:bcl-2-Associated X Protein; D000226:Mitochondrial ADP, ATP Translocases