Factors useful in predicting the success of oocyte donation: a 3-year retrospective analysis.
OBJECTIVE
To establish prognostic relevance of parameters assessed in oocyte donation cycles.


METHODS
Retrospective analysis.


METHODS
Large university-based donor oocyte program.


METHODS
All oocyte recipient cycles achieving embryo transfer from September 1995 to October 1998.


METHODS
None.


METHODS
Pregnancy.


RESULTS
Recipient age and reproductive status, day 9 and 12 serum estradiol (E(2)) levels and a progesterone (P) level obtained 2 days after initiation of hormonal therapy did not correlate with pregnancy. Endometrial thickness, but not endometrial pattern, was useful in predicting pregnancy outcome. The clinical pregnancy and live-birth rate in cycles where the endometrial thickness was less than 8 mm was significantly lower when compared to cycles with an endometrial thickness > or =9 mm. Cycles where optimal quality embryos were transferred had the highest implantation (36%), clinical pregnancy (63%) and live birth (54%) rates and these rates were significantly higher than those of cycles where only poor quality embryos were available for transfer (10% implantation, 17% clinical pregnancy, and 8% live birth rates, respectively; P<.05).


CONCLUSIONS
The most reliable predictive factors for pregnancy in oocyte donation cycles are the quality of the embryos transferred and the recipient's mid-cycle endometrial thickness. Recipient monitoring should minimally include ultrasound assessment of endometrial thickness.
Noyes
N
N
Program for IVF, Reproductive Surgery and Infertility, Department of Obstetrics and Gynecology, New York University Medical Center, New York, New York, USA. nnoyes01@aol.com
Hampton
B S
BS
Berkeley
A
A
Licciardi
F
F
Grifo
J
J
Krey
L
L
D000328:Adult; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000502:physiology; D004717:Endometrium / Q000000981:diagnostic imaging; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology; D008875:Middle Aged; D018587:Oocyte Donation; D011237:Predictive Value of Tests; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011379:Prognosis; D012189:Retrospective Studies; D013997:Time Factors; D014463:Ultrasonography
D011374:Progesterone; D004958:Estradiol