title: The Th2 cytokines IL-4 and IL-10 are not crucial for the completion of allogeneic pregnancy in mice.
abstract: The physiological protection from fetal rejection is believed to be dependent on a Th2 type of inflammatory response at the maternal-fetal interface and the cytokines IL-4 and IL-10 have been suggested to play a critical role. We here present data from breeding experiments with IL-10 and IL-4 double-deficient mice indicating that neither maternal nor feto-placental deficiency of these cytokines are crucial for fetal or neonatal survival. The present study does not analyse possible developmental effects of maternal or fetal IL-10 and IL-4 double-deficiency in detail, but shows that an apparently normal breeding can be achieved in different crossings, providing that the mice are kept under very clean conditions.
authors: Section of Medical Inflammation Research, Department of Cell and Molecular Biology, Lund University, Lund, Sweden.
authors: L
authors: L
authors: Svensson
authors: M
authors: M
authors: Arvola
authors: M A
authors: MA
authors: Sällström
authors: R
authors: R
authors: Holmdahl
authors: R
authors: R
authors: Mattsson
mesh_terms: D000818:Animals; D003433:Crosses, Genetic; D004622:Embryo, Mammalian / Q000276:immunology; D005260:Female; D016753:Interleukin-10 / Q000172:deficiency* / Q000235:genetics; D015847:Interleukin-4 / Q000172:deficiency* / Q000235:genetics; D051379:Mice; D008817:Mice, Mutant Strains; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000276:immunology*; D018418:Th2 Cells; D014599:Uterus / Q000276:immunology
chemical_list: D016753:Interleukin-10; D015847:Interleukin-4