Studies on the total synthesis of RP 66453: synthesis of fully functionalized 15-membered biaryl-containing macrocycle.
[structure: see text] Palladium-catalyzed Suzuki cross-coupling, Corey's enantioselective alkylation of glycine template, and macrolactamization are key steps in an efficient synthesis of the 15-membered macrocycle 2.
Boisnard
S
S
Institut de Chimie des Substances Naturelles, CNRS, 91198 Gif-sur-Yvette Cedex, France.
Carbonnelle
A C
AC
Zhu
J
J
D000192:Actinomycetales / Q000737:chemistry*; D000478:Alkylation; D005998:Glycine / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry
D010455:Peptides; C113326:RP 66453, secondary peptide; D005998:Glycine