Lack of association between an interleukin 1 beta (IL-1beta) gene variation and refractory temporal lobe epilepsy.
OBJECTIVE
We attempted to confirm recent findings of Kanemoto et al. that demonstrated a positive association (p < 0.017) between a polymorphism in the promoter region of the interleukin 1-beta (IL-1beta) gene and the clinical phenotype of temporal lobe epilepsy with hippocampal sclerosis (TLE+HS).


METHODS
We determined the frequency of this polymorphism in a group of 61 TLE+HS patients of European ancestry and compared it with that found in 119 ethnically matched control subjects.


RESULTS
Analysis of genotype and allele frequencies showed no statistically significant difference in the distribution of the polymorphism between the two groups (p = 0.10).


CONCLUSIONS
These data suggest that this IL-1beta promoter polymorphism does not act as a strong susceptibility factor for TLE+HS in a population of individuals of European ancestry.
Buono
R J
RJ
Center for Neurobiology and Behavior, Department of Psychiatry, University of Pennsylvania School of Medicine, 415 Curie Blvd., Philadelphia, PA 19104-6140, U.S.A. rjbuono@mail.med.upenn.edu
Ferraro
T N
TN
O'Connor
M J
MJ
Sperling
M R
MR
Ryan
S G
SG
Scattergood
T
T
Mulholland
N
N
Gilmore
J
J
Lohoff
F W
FW
Berrettini
W H
WH
D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000453:epidemiology / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics; D005060:Europe / Q000208:ethnology; D005787:Gene Frequency / Q000235:genetics; D020022:Genetic Predisposition to Disease; D014644:Genetic Variation; D005838:Genotype; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000235:genetics*; D053583:Interleukin-1beta; D010446:Peptide Fragments / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D012598:Sclerosis; D014481:United States / Q000453:epidemiology; D044465:White People / Q000235:genetics
D007375:Interleukin-1; D053583:Interleukin-1beta; D010446:Peptide Fragments; C052994:interleukin-1beta (163-171)