[Synthesis and pharmacological study of 7-phenyl-1,4-diazepin-5-one and its derivatives].
We studied the synthesis and psychotropic activity of the 7-phenyl-1,4-diazepin-5-one and derivatives. It can be conclude that these products have sedative, myorelaxant and anxiolytic actions. The toxicity study demonstrated that two diazepines are non-toxic at therapeutic dosages but that a third compound is very toxic.
Chammache
M
M
Laboratoire de Chimie Organique Hétérocyclique, Faculté des Sciences, Avenue Ibn Battouta, BP 1014 Rabat (Maroc).
Zellou
A
A
Essassi
E M
EM
Cherrah
Y
Y
Hassar
M
M
D000818:Animals; D001522:Behavior, Animal; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
C432903:7-phenyl-1,4-diazepin-5-one; D001555:Benzene Derivatives; D006573:Heterocyclic Compounds, 1-Ring; D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs