Tcf-3 expression and beta-catenin mediated transcriptional activation in aggressive fibromatosis (desmoid tumour).
Aggressive fibromatosis harbours mutations resulting in beta-catenin protein stabilization. Primary cell cultures demonstrate constitutive tcf activation in aggressive fibromatosis. Expression and co-immunoprecipitation studies suggest that beta-catenin binds and activates tcf-3 in this tumour. This is the first demonstration of tcf-3 activation by beta-catenin stabilization in a human neoplastic process.
Tejpar
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S
The Program in Developmental Biology, The Hospital for Sick Children and the University of Toronto, 555 University Avenue, Toronto, Ontario, M5G1X8, Canada
Li
C
C
Yu
C
C
Poon
R
R
Denys
H
H
Sciot
R
R
Van Cutsem
E
E
Cassiman
J J
JJ
Alman
B A
BA
D003598:Cytoskeletal Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D018222:Desmoid Tumors / Q000235:genetics* / Q000378:metabolism*; D024002:HMGB Proteins; D006801:Humans; D011233:Precipitin Tests; D051820:TCF Transcription Factors; D015534:Trans-Activators; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors / Q000096:biosynthesis* / Q000378:metabolism; D015533:Transcriptional Activation / Q000502:physiology*; D014407:Tumor Cells, Cultured; D051176:beta Catenin
C495270:CTNNB1 protein, human; D003598:Cytoskeletal Proteins; D024002:HMGB Proteins; D051820:TCF Transcription Factors; C544912:TCF7L1 protein, human; D015534:Trans-Activators; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors; D051176:beta Catenin