BBG2Na an RSV subunit vaccine candidate intramuscularly injected to human confers protection against viral challenge after nasal immunization in mice.
Respiratory syncytial virus (RSV) is a major respiratory pathogen responsible for severe pulmonary disease. We have developed a parenterally administered vaccine, BBG2Na, which is currently in a phase III clinical trial. BBG2Na comprises residues 130--230 of RSV-A G protein (G2Na) fused to the BB carrier protein. In this study, we show that BBG2Na can be delivered by the nasal route and generates both mucosal and systemic antibody responses when co-administered with cholera toxin B or a newly described delivery system, zwittergent 3--14. We found that nasal BBG2Na administration protects against RSV challenge and does not induce lung immunopathology upon subsequent RSV challenge.
Goetsch
L
L
Centre d'Immunologie Pierre Fabre, 5 avenue Napoléon III, B.P. 497, F-74164 St Julien en Genevois, France.
Plotnicky-Gilquin
H
H
Aubry
J P
JP
De-Lys
P
P
Haeuw
J F
JF
Bonnefoy
J Y
JY
Nguyen
N T
NT
Corvaïa
N
N
Velin
D
D
D000281:Administration, Intranasal; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D002772:Cholera Toxin / Q000008:administration & dosage; D005260:Female; D015707:HN Protein / Q000276:immunology; D006801:Humans; D018928:Immunity, Mucosal; D007273:Injections, Intramuscular; D051379:Mice; D008807:Mice, Inbred BALB C; D009297:Nasal Mucosa / Q000187:drug effects / Q000473:pathology; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000633:toxicity; D022261:Respiratory Syncytial Virus Vaccines / Q000008:administration & dosage*; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D022223:Vaccines, Subunit / Q000008:administration & dosage; D014759:Viral Envelope Proteins
D000914:Antibodies, Viral; D015707:HN Protein; D000644:Quaternary Ammonium Compounds; D022261:Respiratory Syncytial Virus Vaccines; D022223:Vaccines, Subunit; D014759:Viral Envelope Proteins; C116204:attachment protein G; C048256:zwittergent 3-14; D002772:Cholera Toxin