Oxidative stress-induced activation of Lyn recruits sphingomyelinase and is requisite for its stimulation by Ara-C.
Bezombes
C
C
INSERM E9910, Institut Claudius Réaud, Toulouse 31052, France.
Plo
I
I
Mansat-De Mas
V
V
Quillet-Mary
A
A
Nègre-Salvayre
A
A
Laurent
G
G
Jaffrézou
J P
JP
D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology*; D017209:Apoptosis; D003561:Cytarabine / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D018922:HL-60 Cells; D006801:Humans; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism; D018384:Oxidative Stress / Q000502:physiology; D017382:Reactive Oxygen Species / Q000378:metabolism; D015398:Signal Transduction; D013108:Sphingomyelin Phosphodiesterase / Q000378:metabolism*; D020298:U937 Cells; D019061:src-Family Kinases / Q000378:metabolism*
D000964:Antimetabolites, Antineoplastic; D017382:Reactive Oxygen Species; D003561:Cytarabine; D004247:DNA; C060902:lyn protein-tyrosine kinase; D019061:src-Family Kinases; D048031:JNK Mitogen-Activated Protein Kinases; D020928:Mitogen-Activated Protein Kinases; D013108:Sphingomyelin Phosphodiesterase