title: Novel sulfonate derivatives: potent antimitotic agents.
abstract: The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
authors: Cancer Research, D47B, Building AP-10, Abbott Laboratories, 60064-6101, Abbott Park, IL, USA
authors: S L
authors: SL
authors: Gwaltney
authors: H M
authors: HM
authors: Imade
authors: Q
authors: Q
authors: Li
authors: L
authors: L
authors: Gehrke
authors: R B
authors: RB
authors: Credo
authors: R B
authors: RB
authors: Warner
authors: J Y
authors: JY
authors: Lee
authors: P
authors: P
authors: Kovar
authors: D
authors: D
authors: Frost
authors: S C
authors: SC
authors: Ng
authors: H L
authors: HL
authors: Sham
mesh_terms: D000627:Aminophenols / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008938:Mitosis / Q000187:drug effects*; D013449:Sulfonamides / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000096926:Benzenesulfonamides
chemical_list: D000627:Aminophenols; D000970:Antineoplastic Agents; D013449:Sulfonamides; D013451:Sulfonic Acids; C079199:E 7010; D000096926:Benzenesulfonamides