title: Functional magnetic resonance imaging of the primary motor cortex in humans: response to increased functional demands.
abstract: Functional magnetic resonance imaging (fMRI) studies have been performed on 20 right handed volunteers at 1.5 Tesla using echo planar imaging (EPI) protocol. Index finger tapping invoked localized activation in the primary motor area. Consistent and highly reproducible activation in the primary motor area was observed in six different sessions of a volunteer over a period of one month. Increased tapping rate resulted in increase in the blood oxygenation level dependent (BOLD) signal intensity as well as the volume/area of activation (pixels) in the contralateral primary motor area up to tapping rate of 120 taps/min (2 Hz), beyond which it saturates. Activation in supplementary motor area was also observed. The obtained results are correlated to increased functional demands.
authors: NMR Research Centre, Institute of Nuclear Medicine and Allied Sciences, Lucknow Road, Delhi 110 054, India. skhushu@drinma.ren.nic.in
authors: S
authors: S
authors: Khushu
authors: S S
authors: SS
authors: Kumaran
authors: R P
authors: RP
authors: Tripathi
authors: A
authors: A
authors: Gupta
authors: P C
authors: PC
authors: Jain
authors: V
authors: V
authors: Jain
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D005260:Female; D005385:Fingers; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009043:Motor Activity; D009044:Motor Cortex / Q000033:anatomy & histology / Q000502:physiology*