B cells with the guts to switch.
Expression of mIgM was thought to be esential for the differentiation of B cells expressing antibodies of other classes. New evidence suggests isotype class switching to IgA can occur in the absence of mIgM.
Clark
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EA
Departments of Immunology and Microbiology, University of Washington, Seattle, WA 98195, USA. eclark@bart.rprc.washington.edu
Otipoby
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KL
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D004268:DNA-Binding Proteins / Q000235:genetics / Q000276:immunology; D007070:Immunoglobulin A / Q000096:biosynthesis*; D017578:Immunoglobulin Class Switching / Q000276:immunology*; D007127:Immunoglobulin Constant Regions / Q000235:genetics / Q000276:immunology; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M / Q000235:genetics / Q000276:immunology*; D007138:Immunoglobulin delta-Chains / Q000235:genetics / Q000276:immunology; D007139:Immunoglobulin epsilon-Chains / Q000235:genetics / Q000276:immunology; D007148:Immunoglobulin mu-Chains / Q000235:genetics / Q000276:immunology; D007422:Intestines / Q000166:cytology*
D004268:DNA-Binding Proteins; D007070:Immunoglobulin A; D007127:Immunoglobulin Constant Regions; D007132:Immunoglobulin Isotypes; D007075:Immunoglobulin M; D007138:Immunoglobulin delta-Chains; D007139:Immunoglobulin epsilon-Chains; D007148:Immunoglobulin mu-Chains; C064655:V(D)J recombination activating protein 2