Powerful ideas driven by simple tools: lessons from experimental embryology.
In developmental biology, as in all scientific fields, conceptual advances are tightly coupled to technological innovation. In this review, we trace the evolution of techniques in experimental embryology, from classical ablation to the latest methods utilizing in vivo electroporation, with lens induction as a linking theme.
Weaver
M
M
Department of Cell Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA.
Hogan
B
B
D000818:Animals; D001709:Biotechnology / Q000379:methods / Q000639:trends; D015509:Developmental Biology / Q000266:history*; D005123:Eye / Q000196:embryology*; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D007908:Lens, Crystalline / Q000196:embryology