title: [Lavage of the birth canal with chlorhexidine: a new valid method for the prevention of perinatal infections].
abstract: Perinatal morbidity and mortality are due to various infective agents, mainly represented by beta-hemolytic group B Streptococcus. The perinatal disease related to this infection is distinguished in Early-onset, characterised by pneumonia and sepsis, and Late-onset which leads to sepsis, meningitis and pneumonia. Various strategies were therefore proposed to prevent transmission including immunisation and chemoprophylaxis. All these methods however present adverse effects and are most of all expensive to carry out. Taha et al. reported an interesting experience regarding the reduction of perinatal infections following the cleansing of the birth canal with a solution of Chlorhexidine 0.25% during labour (1996-1997). It seemed interesting for us to assess the applicability and efficacy of a new strategy of prophylaxis of perinatal infections in a Developing Country based on the association of two of the simple strategies proposed i.e.: cleansing the birth canal with chlorhexidine and chemoprophylaxis in cases with risk factors without culture screening. We studied two groups of patients: one in which cleansing of the birth canal was used and the second (control group) in which the old method already applied in the hospital (i.e. cleansing of the external genitals with Cetrimide 1%+ Chlorhexidine 0.1%) was carried out associated with antibiotic therapy when risk factors arose. We observed a total absence of neonatal mortality due to sepsis resulting from the association of the methods suggested even though the presence of sepsis evaluated through signs and symptoms like fever, poor feeding, apnoea or dyspnoea in newborns was similar in both groups.
authors: Cattedra di Ginecologia e Ostetricia, Clinica Ostetrica e Ginecologica, Università degli Studi di Parma.
authors: C T
authors: CT
authors: Kaihura
authors: L
authors: L
authors: Ricci
authors: L
authors: L
authors: Bedocchi
authors: G
authors: G
authors: Barbara
authors: T
authors: T
authors: Rossi
authors: G
authors: G
authors: Benassi
authors: L
authors: L
authors: Benassi
mesh_terms: D002710:Chlorhexidine / Q000627:therapeutic use*; D004202:Disinfectants / Q000627:therapeutic use*; D004203:Disinfection; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011295:Prenatal Care; D013290:Streptococcal Infections / Q000517:prevention & control*; D013292:Streptococcus agalactiae
chemical_list: D004202:Disinfectants; D002710:Chlorhexidine