title: The effects of oral melatonin on the autonomic function in healthy subjects.
abstract: We investigated the influence of melatonin on the human autonomic functions by measuring muscle sympathetic nerve activity (MSNA). Five healthy male volunteers took 3 mg of melatonin, and their plasma melatonin concentration, blood pressure, heart rate, and burst rate of MSNA were then recorded. The peak level of melatonin concentration showed a marked interindividual variation. Blood pressure was reduced significantly, while heart rate and burst rate of MSNA did not change significantly. These results indicate that melatonin has a hypotensive effect on blood pressure, and the central cardiovascular regulatory mechanism such as lowering of the baroreflex setpoint would be involved in the effect.
authors: Department of Neuropsychiatry, Akita University School of Medicine, Akita, Japan. t-kitajima@ya2.so.net.ne.jp
authors: T
authors: T
authors: Kitajima
authors: T
authors: T
authors: Kanbayashi
authors: Y
authors: Y
authors: Saitoh
authors: Y
authors: Y
authors: Ogawa
authors: T
authors: T
authors: Sugiyama
authors: Y
authors: Y
authors: Kaneko
authors: Y
authors: Y
authors: Sasaki
authors: R
authors: R
authors: Aizawa
authors: T
authors: T
authors: Shimisu
mesh_terms: D000284:Administration, Oral; D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D004569:Electroencephalography; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology*; D006801:Humans; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D010543:Peroneal Nerve / Q000187:drug effects
chemical_list: D008550:Melatonin