Error threshold for spatially resolved evolution in the quasispecies model.
The error threshold for quasispecies in 1, 2, 3, and infinity dimensions is investigated by stochastic simulation and analytically. The results show a monotonic decrease in the maximal sustainable error probability with decreasing diffusion coefficient, independently of the spatial dimension. It is thereby established that physical interactions between sequences are necessary in order for spatial effects to enhance the stabilization of biological information. The analytically tractable behavior in an infinity-dimensional (simplex) space provides a good guide to the spatial dependence of the error threshold in lower dimensional Euclidean space.
Altmeyer
S
S
Biomolecular Information Processing, BioMIP, GMD-German National Research Center for Information Technology, Schloss Birlinghoven, 53754 St. Augustin, Germany.
McCaskill
J S
JS
D019143:Evolution, Molecular; D008957:Models, Genetic; D013269:Stochastic Processes