Breaking the mitochondrial barrier.
Pro- and anti-apoptotic members of the Bcl-2 family control the permeability of the outer mitochondrial membrane. They could do this either by forming autonomous pores in the membrane or by collaborating with components of the permeability transition pore. Here we discuss why we favour the first of these possibilities.
Martinou
J C
JC
Departement de Biologie Cellulaire, Sciences III, 30 quai Ernest Ansermet, 1211 Genève 4, Switzerland. Jean-Claude.Martinou@cellbio.unige.ch.
Green
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DR
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D007425:Intracellular Membranes / Q000502:physiology; D008928:Mitochondria / Q000502:physiology*; D008954:Models, Biological; D011518:Proto-Oncogene Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000502:physiology; D051028:bcl-2-Associated X Protein
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D051028:bcl-2-Associated X Protein