[Antihypertensive effect of Herniaria glabra saponins in the spontaneously hypertensive rat].
We studied the antihypertension action of Herniaria glabra saponins and compared the effect with that of furosemide. Spontaneously hypertensive rats were treated with H. glabra saponins at a dosage of 200mg/Kg of body weight. Treatment led to progressive decline in both systolic and diastolic blood pressures. After one month of therapy, pressures were: 141,60+/-7,51 / 90,40+/-5.46mmHg versus 187,60+/-5,94/119,10+/-7.79mmHg (p<0,001). We did not observe any change in heart rate. H. glabra saponins were able to lower blood pressure by a multifactorial mechanism.
Rhiouani
H
H
Laboratoire de Pharmacologie, Faculté de Médecine et de Pharmacie, Rabat, Maroc.
Lyoussi
B
B
Settaf
A
A
Cherrah
Y
Y
Hassar
M
M
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy* / Q000235:genetics; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR; D012503:Saponins / Q000494:pharmacology* / Q000633:toxicity
D000959:Antihypertensive Agents; D012503:Saponins; D009543:Nifedipine