Cloning and chromosome mapping of human and chicken Iroquois (IRX) genes.
Three highly homologous homeobox genes (caupolican, araucan and mirror) have been identified in Drosophila. These genes belong to the novel Iroquois complex, which acts as a pre-pattern molecule in Drosophila neurogenesis. Recently several vertebrate Iroquois homologues (Irx) were isolated and found to be involved in pattern formation of various tissues. Here we report cytogenetic mapping of four human and five chicken Iroquois genes by FISH. Our findings revealed that vertebrate Irx genes are clustered at two different loci.
Ogura
K
K
Graduate School of Biological Sciences, Nara Institute of Science and Technology, Nara, Japan. ogura@bs.aist-nara.ac.jp
Matsumoto
K
K
Kuroiwa
A
A
Isobe
T
T
Otoguro
T
T
Jurecic
V
V
Baldini
A
A
Matsuda
Y
Y
Ogura
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D019521:Body Patterning / Q000235:genetics; D002645:Chickens / Q000235:genetics*; D002885:Chromosomes, Human, Pair 16 / Q000235:genetics; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics; D003001:Cloning, Molecular; D018398:Homeodomain Proteins / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics*; D010802:Phylogeny; D020161:Physical Chromosome Mapping; D017385:Sequence Homology; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*
D018398:Homeodomain Proteins; D014157:Transcription Factors