ALT-711 decreases cardiovascular stiffness and has potential in diabetes, hypertension and heart failure.
Vascular and/or myocardial stiffness is a major problem in ageing, diabetes, hypertension and heart failure. The development of the stiffness is partly due to the formation of glucose-dependent cross-links in the collagen. ALT-711 cleaves these cross-links. In aged-rhesus monkeys, ALT-711 decreases vascular stiffness and this effect is reversible. ALT-711 also decreases myocardial stiffness in the monkeys but this effect is not reversible in 39 weeks. ALT-711 has potential in the treatment of the stiffness associated with diabetes, hypertension and heart failure.
Doggrell
S A
SA
Doggrell Biomedical Communications, Lynfield, Auckland, New Zealand. s_doggrell@yahoo.com
D000818:Animals; D003920:Diabetes Mellitus / Q000188:drug therapy*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D013844:Thiazoles / Q000627:therapeutic use*
D013844:Thiazoles; C406794:alagebrium