Regulation of hypoxia-induced angiogenesis: a chaperone escorts VEGF to the dance.
Semenza
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Institute of Genetic Medicine, The Johns Hopkins University School of Medicine, CMSC-1004, 600 N. Wolfe Street, Baltimore, Maryland 21287-3914, USA. gsemenza@jhmi.edu
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D015687:Cell Hypoxia; D004268:DNA-Binding Proteins / Q000502:physiology; D003921:Diabetes Mellitus, Experimental / Q000150:complications; D016228:Endothelial Growth Factors / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D005786:Gene Expression Regulation / Q000187:drug effects; D015316:Genetic Therapy; D005822:Genetic Vectors / Q000008:administration & dosage / Q000235:genetics; D018840:HSP70 Heat-Shock Proteins; D006439:Hemodynamics; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008222:Lymphokines / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D018832:Molecular Chaperones / Q000502:physiology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D018919:Neovascularization, Physiologic / Q000502:physiology*; D009687:Nuclear Proteins / Q000502:physiology; D010100:Oxygen / Q000494:pharmacology; D021381:Protein Transport; D011506:Proteins / Q000502:physiology*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics; D016372:RNA, Antisense / Q000494:pharmacology; D012333:RNA, Messenger / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis / Q000235:genetics; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D040281:Vascular Endothelial Growth Factor Receptor-1; D042442:Vascular Endothelial Growth Factors; D014945:Wound Healing / Q000502:physiology
D004268:DNA-Binding Proteins; D016228:Endothelial Growth Factors; C497442:HIF1A protein, human; D018840:HSP70 Heat-Shock Proteins; C497443:Hif1a protein, mouse; D051793:Hypoxia-Inducible Factor 1; D051795:Hypoxia-Inducible Factor 1, alpha Subunit; D008222:Lymphokines; D018832:Molecular Chaperones; D009687:Nuclear Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D016372:RNA, Antisense; D012333:RNA, Messenger; D014157:Transcription Factors; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; C050087:oxygen-regulated proteins; D020794:Receptor Protein-Tyrosine Kinases; D040281:Vascular Endothelial Growth Factor Receptor-1; D010100:Oxygen