title: A randomized controlled double-blind trial comparing piritramide and morphine for analgesia after hysterectomy.
abstract: OBJECTIVE
  Efficacy and side-effects of piritramide (pirinitramide) and morphine, given intravenously for postoperative analgesia after hysterectomy, were compared in a randomized controlled double-blind trial in 92 ASA class I-III patients.
  
  
  METHODS
  Administration was investigator-controlled during the first 90 min and subsequently via a patient-controlled device. Visual analogue scales for pain intensity and verbal rating scales for side-effects were taken repeatedly.
  
  
  RESULTS
  Median visual analogue scores for pain intensity on a 100-mm scale 4, 8 and 24 h after surgery were 10, 8.5 and 5 mm in the piritramide group and 18, 10 and 8.5 mm in the morphine group. These differences are neither statistically nor clinically significant. Median values for nausea on a verbal rating scale from 0 to 3 were zero for both groups at all times with similar ranges. There was no difference in number of episodes of vomiting and retching and usage of antiemetics. The mean amount of piritramide used for initial titration was 15.2 mg; the respective amount of morphine was 15.4 mg.
  
  
  CONCLUSIONS
  In this setting the two agents are equally effective and show a similar profile of side-effects.
authors: Department for Anaesthesiology and Intensive Care, Charité Hospital Campus Mitte, Schumannstrasse 20/21, 10117 Berlin, Germany.
authors: U R
authors: UR
authors: Döpfmer
authors: M R
authors: MR
authors: Schenk
authors: S
authors: S
authors: Kuscic
authors: D H
authors: DH
authors: Beck
authors: S
authors: S
authors: Döpfmer
authors: W J
authors: WJ
authors: Kox
mesh_terms: D016058:Analgesia, Patient-Controlled; D000701:Analgesics, Opioid / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009020:Morphine / Q000009:adverse effects / Q000627:therapeutic use*; D010147:Pain Measurement; D010149:Postoperative Pain / Q000188:drug therapy*; D010892:Pirinitramide / Q000009:adverse effects / Q000627:therapeutic use*; D020250:Postoperative Nausea and Vomiting / Q000453:epidemiology
chemical_list: D000701:Analgesics, Opioid; D010892:Pirinitramide; D009020:Morphine