title: [Prognostication of obstructive syndrome in patients with chronic bronchitis considering hereditary factors].
abstract: OBJECTIVE
  To propose method of accurate prediction of chronic obstructive pulmonary disease (COPD) at early stages of development.
  
  
  METHODS
  92 males with COPD and 55 males with chronic non-obstructive bronchitis aged 38 to 72 years were examined according to a technique which identifies hereditary predisposition to multifactor diseases and using an algorithm based on multivariate analysis.
  
  
  RESULTS
  An original mathematical model is proposed which can quantitatively examine and range by influence the role of environmental and hereditary factors in development of COPD.
  
  
  CONCLUSIONS
  Detection of hereditary predisposition to COPD may be one of the objective criteria to recommend giving up smoking and for occupational orientation.
authors: T V
authors: TV
authors: Ivchik
authors: A N
authors: AN
authors: Kokosov
authors: G I
authors: GI
authors: Razorenov
authors: T S
authors: TS
authors: Razorenova
authors: N G
authors: NG
authors: Iakovleva
mesh_terms: D000328:Adult; D000368:Aged; D000465:Algorithms; D001991:Bronchitis / Q000150:complications* / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control; D002908:Chronic Disease; D005819:Genetic Markers; D020022:Genetic Predisposition to Disease; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D008962:Models, Theoretical; D015999:Multivariate Analysis; D011379:Prognosis
chemical_list: D005819:Genetic Markers