The bacterial toxin toolkit.
Pathogenic bacteria and higher eukaryotes have spent a long time together, leading to a precise understanding of one another's way of functioning. Through rapid evolution, bacteria have engineered increasingly sophisticated weapons to hit exactly where it hurts, interfering with fundamental host functions. However, toxins are not only useful to the bacteria - they have also become an essential asset for life scientists, who can now use them as toolkits to explore cellular processes.
Schiavo
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Imperial Cancer Research Fund, 44 Lincoln's Inn Fields, London WC2A 3PX, UK. g.schiavo@icrf.icnet.uk
van der Goot
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FG
D001427:Bacterial Toxins / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology*; D002448:Cell Adhesion; D002462:Cell Membrane / Q000502:physiology; D016764:Cell Polarity; D003599:Cytoskeleton / Q000187:drug effects / Q000378:metabolism; D004705:Endocytosis / Q000187:drug effects* / Q000502:physiology; D008561:Membrane Fusion; D021381:Protein Transport; D015398:Signal Transduction / Q000187:drug effects* / Q000502:physiology; D020798:Two-Hybrid System Techniques
D001427:Bacterial Toxins