Intraduodenal and intrajejunal administration of the herbal medicine, dai-kenchu-tou, stimulates small intestinal motility via cholinergic receptors in conscious dogs.
The aim of the present study was to study the effect and mechanism of action of intraduodenal and intrajejunal dai-kenchu-to, an herbal medicine clinically effective for uncomplicated postoperative adhesive intestinal obstruction, on upper gastrointestinal motility. Five mongrel dogs were equipped with four strain-gauge force transducers on the antrum, duodenum, and proximal and distal jejunum to measure contractile activity. Dai-kenchu-to (0.5, 1.5, and 3.0 g) was administered into the duodenal or proximal jejunal lumen. The effect of atropine, hexamethonium, phentolamine, propranolol, and ondansetron on intraduodenal and intrajejunal dai-kenchu-to-induced contractions was studied. Plasma motilin was measured by specific radioimmunoassay. Intraduodenal and intrajejunal dai-kenchu-to induced phasic contractions in the duodenum and proximal jejunum, respectively, and those contractions migrated distally. Phasic contractions induced by intraduodenal and intrajejunal dai-kenchu-to were inhibited by atropine and hexamethonium at all sites. Plasma motilin was not affected by dai-kenchu-to. Intraduodenal and intrajejunal dai-kenchu-to stimulates upper gastrointestinal motility at and distal to the administration sites through cholinergic receptors.
Jin
X L
XL
Department of Surgery, Tohoku University Graduate School of Medicine, Sendai, Japan.
Shibata
C
C
Naito
H
H
Ueno
T
T
Funayama
Y
Y
Fukushima
K
K
Matsuno
S
S
Sasaki
I
I
D000818:Animals; D003243:Consciousness; D004285:Dogs; D004386:Duodenum; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects* / Q000502:physiology*; D007583:Jejunum; D008297:Male; D009037:Motilin / Q000097:blood; D005894:Panax; D004364:Pharmaceutical Preparations; D010936:Plant Extracts / Q000008:administration & dosage*; D010946:Plants, Medicinal; D011950:Receptors, Cholinergic / Q000502:physiology*; D032106:Zanthoxylum; D030521:Zingiberaceae
D004364:Pharmaceutical Preparations; D010936:Plant Extracts; D011950:Receptors, Cholinergic; C121414:dai-kenchu-to; D009037:Motilin