title: Nucleoside analogues as highly potent and selective inhibitors of herpes simplex virus thymidine kinase.
abstract: A series of carboxamide derivatives of 5'-amino-2',5'-dideoxy-5-ethyluridine has been prepared as inhibitors of HSV-TK (herpes simplex virus thymidine kinase). The most potent compounds were derived from xanthene, thioxanthene and dihydroanthracene carboxylic acids. The lead compounds show subnanomolar IC(50) values against HSV TKs.
authors: Department of Medicinal Chemistry, Roche Discovery Welwyn, Broadwater Road, Welwyn Garden City, AL7 3AY, Herts, UK. joseph.martin@roche.com
authors: J A
authors: JA
authors: Martin
authors: R W
authors: RW
authors: Lambert
authors: J H
authors: JH
authors: Merrett
authors: K E
authors: KE
authors: Parkes
authors: G J
authors: GJ
authors: Thomas
authors: S J
authors: SJ
authors: Baker
authors: D J
authors: DJ
authors: Bushnell
authors: J E
authors: JE
authors: Cansfield
authors: S J
authors: SJ
authors: Dunsdon
authors: A C
authors: AC
authors: Freeman
authors: R A
authors: RA
authors: Hopkins
authors: I R
authors: IR
authors: Johns
authors: E
authors: E
authors: Keech
authors: H
authors: H
authors: Simmonite
authors: A
authors: A
authors: Walmsley
authors: P
authors: P
authors: Wong Kai-In
authors: M
authors: M
authors: Holland
mesh_terms: D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology*; D018139:Simplexvirus / Q000201:enzymology*; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors*; D014529:Uridine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*
chemical_list: C434644:5'-amino-2',5'-dideoxy-5-ethyluridine; D004791:Enzyme Inhibitors; D013937:Thymidine Kinase; D014529:Uridine