Effect of anionic polymers on the release of propranolol hydrochloride from matrix tablets.
Anionic polymers, namely Eudragit S, Eudragit L 100-55, and sodium carboxymethylcellulose, were incorporated into hydroxypropylmethylcellulose (HPMC K100M) to modify the drug release from HPMC matrices. The effects of changing the ratio of HPMC to anionic polymers were examined in water and in media with different pH. The dissolution profiles were compared according to release rates. The interaction between propranolol hydrochloride and anionic polymers was confirmed using the UV difference spectra method. The drug release was controlled with the type of anionic polymer and the interaction between propranolol hydrochloride and anionic polymers. The HPMC-anionic polymer ratio also influenced the drug release. The matrix containing HPMC-Eudragit L 100-55 (1:1 ratio) produced pH-independent extended-release tablets in water, 0.1 N HCl, and pH 6.8 phosphate buffer.
Takka
S
S
Industrial Pharmacy Program, College of Pharmacy, University of Cincinnati, Cincinnati, OH, USA. sevgitakka@turk.net
Rajbhandari
S
S
Sakr
A
A
D000180:Acrylic Resins / Q000008:administration & dosage*; D002266:Carboxymethylcellulose Sodium / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D007785:Lactose / Q000008:administration & dosage* / Q000031:analogs & derivatives; D008747:Methylcellulose / Q000008:administration & dosage* / Q000031:analogs & derivatives; D010078:Oxazines; D011109:Polymethacrylic Acids / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage* / Q000737:chemistry; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
D000180:Acrylic Resins; D010078:Oxazines; D011109:Polymethacrylic Acids; D013607:Tablets; C038300:methylmethacrylate-methacrylic acid copolymer; D008747:Methylcellulose; C071191:MK 458; D011433:Propranolol; D007785:Lactose; D002266:Carboxymethylcellulose Sodium