title: Components of astrocytic intercellular calcium signaling.
abstract: It has become evident that astrocytes play major roles in central nervous system (CNS) function. Because they are endowed with ion channels, transport pathways, and enzymatic intermediates optimized for ionic uptake, degradation of metabolic products, and inactivation of numerous substances, they are able to sense and correct for changes in neural microenvironment. Besides this housekeeping role, astrocytes modulate neuronal activity either by direct communication through gap junctions or through the release of neurotransmitters and/or nucleotides affecting nearby receptors. One prominent mode by which astrocytes regulate their own activity and influence neuronal behavior is via Ca2+ signals, which may be restricted within one cell or be transmitted throughout the interconnected syncytium through the propagation of intercellular calcium waves. This review aims to outline the most recent advances regarding the active communication of astrocytes that is encoded by intracellular calcium variation.
authors: Department of Neuroscience, Kennedy Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA.
authors: E
authors: E
authors: Scemes
mesh_terms: D000246:Adenosine Diphosphate Ribose / Q000031:analogs & derivatives* / Q000502:physiology; D000255:Adenosine Triphosphate / Q000502:physiology; D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D019703:Calcineurin / Q000502:physiology; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000502:physiology; D020013:Calcium Signaling / Q000187:drug effects / Q000502:physiology*; D002450:Cell Communication; D017630:Connexins / Q000502:physiology; D036563:Cyclic ADP-Ribose; D005110:Extracellular Space / Q000378:metabolism; D017629:Gap Junctions / Q000502:physiology; D015726:Giant Cells / Q000378:metabolism; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007375:Interleukin-1 / Q000494:pharmacology; D017136:Ion Transport; D009419:Nerve Tissue Proteins / Q000502:physiology; D009474:Neurons / Q000378:metabolism; D018377:Neurotransmitter Agents / Q000494:pharmacology / Q000502:physiology; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D018160:Receptors, Cytoplasmic and Nuclear / Q000502:physiology; D018048:Receptors, Purinergic P2 / Q000187:drug effects / Q000502:physiology; D058473:Receptors, Purinergic P2Y2; D010738:Type C Phospholipases / Q000502:physiology
chemical_list: D015220:Calcium Channels; D017630:Connexins; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D007375:Interleukin-1; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; C546385:P2RY2 protein, human; D018160:Receptors, Cytoplasmic and Nuclear; D018048:Receptors, Purinergic P2; D058473:Receptors, Purinergic P2Y2; D036563:Cyclic ADP-Ribose; D000246:Adenosine Diphosphate Ribose; D018698:Glutamic Acid; D000255:Adenosine Triphosphate; D019703:Calcineurin; D010738:Type C Phospholipases; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D002118:Calcium