title: Anticonvulsant effects of new morphinan derivatives.
abstract: We synthesized a series of compounds that are modified in positions 3 and 17 of the morphinan ring system, with the intention of developing ideal anticonvulsant agents. We examined the effects of these compounds on kainic acid (KA)-induced seizures, and on locomotor patterns in rats. We found that compounds 5, 6, and 8 exhibit novel anticonvulsant effects, with negligible psychotropic effects.
authors: Neurotoxicology Program, Department of Pharmacy, College of Pharmacy, Korea Institute of Drug Abuse, Kangwon National University, 200-701, Chunchon, South Korea. kimhc@cc.kangwon.ac.kr
authors: H C
authors: HC
authors: Kim
authors: T
authors: T
authors: Nabeshima
authors: W K
authors: WK
authors: Jhoo
authors: K H
authors: KH
authors: Ko
authors: W K
authors: WK
authors: Kim
authors: E J
authors: EJ
authors: Shin
authors: M
authors: M
authors: Cho
authors: P H
authors: PH
authors: Lee
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000737:chemistry / Q000494:pharmacology*; D009019:Morphinans / Q000737:chemistry / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
chemical_list: D000927:Anticonvulsants; D009019:Morphinans