Antimycobacterial activity of 9-sulfonylated/sulfenylated-6-mercaptopurine derivatives.
A series of 9-sulfonylated/sulfenylated-6-mercaptopurines has been prepared by reaction of 6-mercaptopurine with sulfonyl/sulfenyl halides. These compounds constitute a new class of potent antimycobacterial agents, possessing MIC values against Mycobacterium tuberculosis H37Rv in the range of 0.39-3.39 microg/mL, as well as appreciable activity against Mycobacterium avium. Furthermore, a compound of this small series exhibited good activity (MIC under 1 microg/mL) against several drug resistant strains of M. tuberculosis.
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Laboratorio di Chimica Inorganica e Bioinorganica, Università degli Studi, Via Gino Capponi 7, I-50121, Florence, Italy.
Mastrolorenzo
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Supuran
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D000818:Animals; D000995:Antitubercular Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D004352:Drug Resistance, Microbial; D015122:Mercaptopurine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009162:Mycobacterium avium / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D014709:Vero Cells
D000995:Antitubercular Agents; D015122:Mercaptopurine