Radioimmunotherapy with iodine-131 tositumomab in patients with low-grade non-Hodgkin's B-cell lymphoma does not induce loss of acquired humoral immunity against common antigens.
Thirty-one previously untreated patients with follicular low-grade B-cell non-Hodgkin's lymphoma expressing the CD20 antigen were treated with iodine-131 tositumomab therapy between 1996 and 1998. The therapy led to a temporary depletion of peripheral blood B-lymphocytes. Recovery of B-cells occurred in most cases by 3 to 6 months and in all patients by 12 months posttherapy. A temporary decline in T-cell subpopulations, but no reduction in serum immunoglobulin levels, could be observed. ELISA techniques were used to detect specific antibodies against rubella, mumps, varicella zoster, measles, and tetanus. Almost all patients remained seropositive against the different antigens during the 1- to 2-year follow-up. No significant reduction in antibody concentrations to tetanus or measles could be detected. The data show that acquired humoral immunity against common antigens appears to be preserved despite a temporary loss of B-lymphocytes.
Nordøy
T
T
Department of Oncology, University Hospital of Tromsø, Tromsø, N-9038, Norway.
Kolstad
A
A
Tuck
M K
MK
Aaberge
I S
IS
Husebekk
A
A
Kaminski
M S
MS
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000009:adverse effects / Q000627:therapeutic use*; D000917:Antibody Formation / Q000187:drug effects / Q000528:radiation effects*; D000942:Antigens, Bacterial / Q000276:immunology*; D018951:Antigens, CD20 / Q000276:immunology; D000951:Antigens, Neoplasm / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology*; D003017:Clostridium tetani / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005500:Follow-Up Studies; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007156:Immunologic Memory; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D016393:Lymphoma, B-Cell / Q000276:immunology / Q000628:therapy*; D008224:Lymphoma, Follicular / Q000276:immunology / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000628:therapy*; D008231:Lymphopenia / Q000209:etiology* / Q000276:immunology; D008297:Male; D008459:Measles virus / Q000276:immunology; D008875:Middle Aged; D009109:Mumps virus / Q000276:immunology; D016499:Radioimmunotherapy; D012412:Rubella virus / Q000276:immunology
D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D018951:Antigens, CD20; D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D007136:Immunoglobulins; D007457:Iodine Radioisotopes; C119496:tositumomab I-131