title: Hope for clomiphene citrate resistant ovaries.
abstract: OBJECTIVE
  To assess the presentation, different surgical modalities and their outcome in the treatment of polycystic ovarian disease.
  
  
  METHODS
  A retrospective study was carried out on 66 patients with polycystic ovarian disease. The majority of the cases had a history of infertility for at least 2 years and were known to be clomiphene citrate resistant in the Saudi German Hospital, Jeddah between 1994 and 1998 undergoing laparoscopic ovarian drilling.
  
  
  RESULTS
  More than 80% of the patients were below 30 years of age. The majority of cases below 30 years had primary infertility. Irregular cycle was the main clinical presentation in 75% of cases; ovarian volume was more than 5.5cm3 in all of the cases. Diathermy drilling was carried out for 50 patients, laser for 12 patients and wedge resection for 4 patients. The follow-up treatment showed that pregnancy rate was 23%, 38% and 0% in the 3 groups. Cases that failed to conceive had significantly higher luteinizing hormone level.
  
  
  CONCLUSIONS
  Laparoscopic ovarian drilling using diathermy or laser is effective during the induction of ovulation and increases the pregnancy rate in cases of polycystic ovarian disease resistant to clomiphene citrate.
authors: Department of Obstetrics & Gynecology, Al-Galaa Teaching Maternity Hospital, Egypt.
authors: M N
authors: MN
authors: Abdul Salam
authors: F H
authors: FH
authors: Hasanain
authors: B K
authors: BK
authors: Greiew
mesh_terms: D000328:Adult; D002996:Clomiphene; D004564:Electrocoagulation; D005260:Female; D005300:Fertility Agents, Female; D006801:Humans; D010535:Laparoscopy; D053685:Laser Therapy; D011085:Polycystic Ovary Syndrome / Q000601:surgery*; D011247:Pregnancy; D018873:Pregnancy Rate; D012189:Retrospective Studies; D016896:Treatment Outcome
chemical_list: D005300:Fertility Agents, Female; D002996:Clomiphene