Liver-derived IGF-I is of importance for normal carbohydrate and lipid metabolism.
IGF-I is important for postnatal body growth and exhibits insulin-like effects on carbohydrate metabolism. The function of liver-derived IGF-I is still not established, although we previously demonstrated that liver-derived IGF-I is not required for postnatal body growth. Mice whose IGF-I gene in the liver was inactivated at 24 days of age were used to investigate the long-term role of liver-derived IGF-I for carbohydrate and lipid metabolism. Serum levels of leptin in these mice were increased by >100% at 3 months of age, whereas the fat mass of the mice was decreased by 25% at 13 months of age. The mice became markedly hyperinsulinemic and yet normoglycemic, indicating an adequately compensated insulin resistance. Furthermore, they had increased serum levels of cholesterol. We conclude that liver-derived IGF-I is of importance for carbohydrate and lipid metabolism.
Sjögren
K
K
Research Center for Endocrinology and Metabolism, Department of Internal Medicine, Sahlgrenska University Hospital, SE-413 45 Göteborg, Sweden.
Wallenius
K
K
Liu
J L
JL
Bohlooly-Y
M
M
Pacini
G
G
Svensson
L
L
Törnell
J
J
Isaksson
O G
OG
Ahrén
B
B
Jansson
J O
JO
Ohlsson
C
C
D015502:Absorptiometry, Photon; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001823:Body Composition / Q000235:genetics; D002678:Chimera; D002784:Cholesterol / Q000097:blood; D004040:Dietary Carbohydrates / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism*; D005260:Female; D020868:Gene Silencing; D007328:Insulin / Q000097:blood; D007333:Insulin Resistance / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000235:genetics / Q000502:physiology*; D050356:Lipid Metabolism; D008099:Liver / Q000737:chemistry*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D007328:Insulin; D007334:Insulin-Like Growth Factor I; D002784:Cholesterol