[Autoimmune peripheral neuropathies with anti-MAG antibodies and hematological disorders. Five cases].
OBJECTIVE
The aim of this study was to report our experience with autoimmune neuropathies associated with hematological disorders and to describe their etiological and clinical polymorphism.


METHODS
A retrospective study was conducted in five patients with autoimmune peripheral neuropathies with anti-MAG (myelin-associated glycoprotein) antibodies.


RESULTS
Autoimmune neuropathies were associated with Waldenström's macroglobulinemia (n=2), Hodgkin disease (n=1), chronic lymphocytic leukemia (n=1) and idiopathic polyclonal B lymphoproliferation (n=1). Most of the patients had a sensorial polyneuropathy, predominant in the legs, exhibiting slow progress. Our patients showed a disappointing response to chemotherapy with stabilization or short response.
Andrès
E
E
Services de Médecine Interne et Nutrition, Clinique Médicale B, Hôpital, 67091 Strasbourg Cedex, France.
Vinzio
S
S
Maloisel
F
F
Carre
S
S
Perrin
A E
AE
Goichot
B
B
Schlienger
J L
JL
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000888:Antibodies, Anti-Idiotypic / Q000097:blood* / Q000276:immunology*; D001327:Autoimmune Diseases / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D006402:Hematologic Diseases / Q000150:complications*; D006689:Hodgkin Disease / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000150:complications* / Q000188:drug therapy; D008232:Lymphoproliferative Disorders / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D018992:Myelin-Associated Glycoprotein / Q000276:immunology*; D011115:Polyneuropathies / Q000097:blood / Q000209:etiology* / Q000276:immunology*; D012189:Retrospective Studies; D016896:Treatment Outcome; D008258:Waldenstrom Macroglobulinemia / Q000150:complications* / Q000188:drug therapy
D000888:Antibodies, Anti-Idiotypic; D018992:Myelin-Associated Glycoprotein