title: Effect of chronic morphine administration on glucose tolerance and insulin binding to isolated rat adipocytes.
abstract: Morphine addiction was induced in six male Wistar rats. Improved glucose tolerance (peak value less by 28%, p<0.01) was observed in chronically morphinized rats as compared to the control rats, injected with saline. An increase in the maximal specific binding of 125I-labeled insulin to unit membrane area of adipocytes was observed in the experimental group (p < 0.01). The changes in insulin receptor number could be responsible for the improved glucose tolerance observed during morphine addiction.
authors: Department of Internal Medicine, Southern Illinois University School of Medicine, Springfield 62794-9636, USA.
authors: A
authors: A
authors: Sood
authors: V S
authors: VS
authors: Thakur
authors: M G
authors: MG
authors: Karmarkar
authors: M M
authors: MM
authors: Ahuja
mesh_terms: D017667:Adipocytes / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D005951:Glucose Tolerance Test; D007328:Insulin / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D009020:Morphine / Q000008:administration & dosage*; D009021:Morphine Dependence / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D001786:Blood Glucose; D007328:Insulin; D007457:Iodine Radioisotopes; D009020:Morphine