title: Endemic (African) Kaposi's sarcoma presenting as a plantar tumour.
abstract: We present a case of the aggressive variant of African endemic Kaposi's Sarcoma (AKS) which presented as a large fungating and ulcerated plantar mass. Our patient responded extremely well to chemotherapy with no recurrence for 9 months after treatment completion. AKS is one of the most common cutaneous neoplasms in black Africans and although rare in Europe, it may be seen more frequently in the future because of the ease of international travel. The existing classification of KS into five different types (classic, African-endemic, iatrogenically immunocompromised patients, epidemic HIV-related and Mediterranean-endemic) cannot address fully the many anomalies described in the disease. The detection of a new herpes simplex-like viral DNA sequence (HHV-8) in different types of KS helps to explain some of the enigma described in this disease.
authors: Unit of Dermatology, Imperial College of Science, Technology and Medicine, Hammersmith Hospital, London UK. epapad@otenet.gr
authors: E
authors: E
authors: Papadavid
authors: R C
authors: RC
authors: Yu
authors: A
authors: A
authors: Katsambas
authors: E
authors: E
authors: Koumantaki
authors: A C
authors: AC
authors: Chu
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005500:Follow-Up Studies; D005534:Foot Diseases / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008297:Male; D012514:Sarcoma, Kaposi / Q000188:drug therapy / Q000473:pathology*