title: [Critical analysis of animal models of acute pain. II].
abstract: OBJECTIVE
  To analyse models of acute pain in experimental animals.
  
  
  METHODS
  References were obtained from computerised bibliographic data banks (Medline and others) and the authors' personal documents.
  
  
  RESULTS
  The majority of tests permit only a measurement of threshold, whereas clinical pain is almost always prolonged. The relationships between tests of acute pain and motor activity are reviewed from a number of standpoints; in particular we consider the influence, which postural adjustments of the animal may exert on motor responses in the limbs and the significance of flexor and extensor reflexes. In analysing the problem of the sensitivity of tests, we raise the following questions: 1) what type(s) of fibres underlie the observed responses and might these be different depending on whether one is stimulating a healthy or an inflamed tissue; 2) what significance do measurements of "latency" have when a stimulus is increasing; 3) how valid are the methods of analysing the results? The influence of species and the genetic line used in tests and the specificity and predictivity of tests are considered. Finally, we review those factors, which may distort behavioural measurements in animals, notably--pharmacokinetics, interactions between heterotopic stimuli, environmental factors and related psychophysiological/psychological considerations (subjective "undesirable" phenomena, learning phenomena). We pay particular attention to related physiological functions (thermoregulation, vasomotricity, blood pressure). These considerations lead us to re-position nociception within a much larger homeostatic framework which in addition to pain, includes phenomena such as anxiety and vegetative functions. They also suggest that we should define an "effective stimulus" as one, which activates nociceptive nerve terminals after a physical stimulus, has passed through a "peripheral lens" which regulates its intensity for reasons, which are physical, albeit of biological origin. Finally they remind us that the "system of pain" forms part of a whole set of subsystems--sensory, motor, vegetative, emotional, motivational--which scientific method, being reductionist by nature, cannot study in its entirety. However one must consider results of nociceptive tests within this general context.
  
  
  CONCLUSIONS
  It is only by taking the approach described in this review, that fundamental and clinical research can interact usefully.
authors: Inserm U-161, 2, rue d'Alésia 75014 Paris, France. lebars@broca.inserm.fr
authors: D
authors: D
authors: Le Bars
authors: M
authors: M
authors: Gozariu
authors: S W
authors: SW
authors: Cadden
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D004195:Disease Models, Animal; D010146:Pain / Q000139:chemically induced / Q000523:psychology*; D010147:Pain Measurement / Q000379:methods*; D017288:Pain Threshold / Q000502:physiology