The cyclohexene ring as bioisostere of a furanose ring: synthesis and antiviral activity of cyclohexenyl nucleosides.
The application of the bioisosteric concept between a furanose ring and a cyclohexene ring in the nucleoside field has led to the discovery of new potent antiviral agents.
Herdewijn
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Laboratory of Medicinal Chemistry, K.U. Leuven, Rega Institute for Medical Research, Minderbroedersstraat 10, B-3000 Leuven, Belgium. piet.herdewijn@rega.kuleuven.ac.be
De Clercq
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E
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology; D003510:Cyclohexanes / Q000737:chemistry*; D053138:Cyclohexenes; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D006151:Guanosine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D006515:Hepatitis B virus / Q000187:drug effects / Q000201:enzymology; D006564:Herpesviridae / Q000187:drug effects / Q000201:enzymology; D020128:Inhibitory Concentration 50; D008958:Models, Molecular; D008968:Molecular Conformation; D018716:Molecular Mimicry; D009705:Nucleosides / Q000737:chemistry* / Q000494:pharmacology; D010429:Pentoses / Q000737:chemistry*; D013237:Stereoisomerism; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors
D000998:Antiviral Agents; D003510:Cyclohexanes; D053138:Cyclohexenes; D004791:Enzyme Inhibitors; D009705:Nucleosides; D010429:Pentoses; D006151:Guanosine; C052568:cyclohexene; D013937:Thymidine Kinase