title: Hydrogen excretion upon ingestion of dairy products in lactose-intolerant male subjects: importance of the live flora.
abstract: OBJECTIVE
  To assess the effects of the ingestion of milk, yoghurt (10(8) bacteria/ml), heat-treated yoghurt (<15 bacteria/ml) and two products obtained by dilution of yoghurt with heat-treated product (10(6) and 10(5) bacteria/ml) on hydrogen production and symptoms of lactose intolerance in lactose malabsorbers.
  
  
  METHODS
  Double-blind, randomised cross-over design.
  
  
  METHODS
  The study was performed in the phase 1 clinical unit of OPTIMED, Nancy, France.
  
  
  METHODS
  Twenty-four male lactose malabsorbers were selected for the study.
  
  
  METHODS
  Hydrogen production and adverse events were followed during 8 h after ingestion of the products.
  
  
  RESULTS
  The results clearly demonstrate that ingestion of yoghurt with 10(8) bacteria/ml leads to lower H(2) excretion and complaints than the other products. Results observed with the products containing a reduced population of live flora remain better than those observed with milk.
  
  
  CONCLUSIONS
  The importance of a high population of the live flora is underlined.
authors: OPTIMED, Gières, France. OPTIMED54@aol.com
authors: X
authors: X
authors: Pelletier
authors: S
authors: S
authors: Laure-Boussuge
authors: Y
authors: Y
authors: Donazzolo
mesh_terms: D000328:Adult; D000818:Animals; D001944:Breath Tests; D015169:Colony Count, Microbial; D018592:Cross-Over Studies; D003611:Dairy Products / Q000382:microbiology*; D004311:Double-Blind Method; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D007785:Lactose / Q000378:metabolism*; D007787:Lactose Intolerance / Q000503:physiopathology*; D008297:Male; D008892:Milk / Q000382:microbiology; D013696:Temperature; D013997:Time Factors; D015014:Yogurt / Q000382:microbiology
chemical_list: D006859:Hydrogen; D007785:Lactose