The chemokine network in eosinophil activation.
Eosinophils are predominant effector cells in allergic and autoimmune diseases attracted by several chemokines into the inflammatory tissue. In the past many new biologically active chemokines have been cloned exploring the gnomic DNA sequence data base in the vicinity of already-known chemokine sequences. This article will help to better understand the chemokine network in eosinophil activation according to the new nomenclature of chemokines. Moreover, possible new therapies, such as chemokine receptor antagonists, for the treatment of allergies are discussed.
Elsner
J
J
Department of Dermatology and Allergology, Hannover Medical University, Ricklinger Str. 5, D-30449, Hannover, Germany.
Kapp
A
A
D018925:Chemokines / Q000378:metabolism*; D002633:Chemotaxis / Q000187:drug effects / Q000502:physiology; D004804:Eosinophils / Q000502:physiology*; D006801:Humans; D019707:Receptors, Chemokine / Q000037:antagonists & inhibitors / Q000378:metabolism
D018925:Chemokines; D019707:Receptors, Chemokine