title: Short-Term prophylaxis with ceftriaxone plus metronidazole in esophageal cancer surgery.
abstract: An open prospective study was carried out in 82 consecutive patients undergoing resective surgery for esophageal cancer from January 1995 to July 1996. Antimicrobial prophylaxis was done using a single dose of ceftriaxone (2 g i.v.) given at the induction of anesthesia in combination with metronidazole (0.5 g i.v.). Two further doses of metronidazole were administered 8 and 16 hours postoperatively. Fourteen patients (17%) experienced postoperative infections. This study, even though open and non-comparative, confirms that ceftriaxone given as a single-dose plus metronidazole provides adequate prophylaxis and significant cost-savings in comparison with multiple-dose prophylactic regimens in patients undergoing major surgery for esophageal cancer. Furthermore, the single-dose regimen reduces the workload for the nursing staff, the risk of side effects, and the possibility of selecting resistant strains.
authors: Clinica Chirurgica IV, The University of Padova School of Medicine, Italy. aruol@ux1.unipd.it
authors: A
authors: A
authors: Ruol
authors: G
authors: G
authors: Bertiato
authors: S
authors: S
authors: Boscarin
authors: R
authors: R
authors: Cusinato
authors: M
authors: M
authors: Pascarella
authors: E A
authors: EA
authors: Tonin
authors: S
authors: S
authors: Santi
authors: E
authors: E
authors: Ancona
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019072:Antibiotic Prophylaxis / Q000191:economics; D001437:Bacteriuria / Q000517:prevention & control; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004938:Esophageal Neoplasms / Q000601:surgery*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007558:Italy; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D012141:Respiratory Tract Infections / Q000517:prevention & control; D013530:Surgical Wound Infection / Q000517:prevention & control*; D016896:Treatment Outcome
chemical_list: D008795:Metronidazole; D002443:Ceftriaxone