Flexible two-stage designs: an overview.
In this overview we introduce the basic ideas behind a new flexible approach in sequential designs. The different concepts based on two-stage combination tests and conditional error functions are brought together. We sketch the construction of p-values, confidence intervals, and median unbiased estimates. Finally, recursive combination tests are introduced which extend the flexibility to the choice of the number of interim analyses.
Bauer
P
P
Department of Medical Statistics, University of Vienna. peter.bauer@univie.ac.at
Brannath
W
W
Posch
M
M
D002986:Clinical Trials as Topic / Q000706:statistics & numerical data*; D003661:Decision Support Techniques; D006801:Humans; D008432:Mathematical Computing; D008492:Medical Informatics Computing; D010865:Pilot Projects; D012107:Research Design / Q000706:statistics & numerical data*