title: Synthesis of new salicylamide derivatives with evaluation of their antiinflammatory, analgesic and antipyretic activities.
abstract: A new series of pyridazine, pyrazoles, pyrazolidine-3,5-dione, Semicarbazide, thiosemicarbazides, hydantoin, thiohydantoins, 1,2,4-triazoles, S-triazolo[3,4-b]-1,3,4-thiadiazoles incorporated indirectly into salicylamide moiety at position 2 were synthesized. Also the synthesis of novel series of 3-salicylamido-2-hydroxypropyl-amine derivatives were prepared. Several of these compounds were screened for antiinflammatory, analgesic, antipyretic and ulcerogenic activities.
authors: Therapeutical Chemistry Department, National Research Centre, Dokki, Cairo, Egypt. hh_fahmy@usa.net
authors: H H
authors: HH
authors: Fahmy
authors: G A
authors: GA
authors: Soliman
mesh_terms: D018712:Analgesics, Non-Narcotic / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000517:prevention & control; D007202:Indicators and Reagents; D008297:Male; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D051381:Rats; D012457:Salicylamides / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D013276:Stomach Ulcer / Q000139:chemically induced
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D007202:Indicators and Reagents; D012457:Salicylamides