title: MR proton spectroscopy in patients with CNS involvement in Bourneville's disease.
abstract: BACKGROUND
  Despite much previous research, the origin of intracranial lesions in tuberous sclerosis is still unknown. We present MR and proton magnetic resonance (1H-MRS) studies of two patients with tuberous sclerosis.
  
  
  METHODS
  The study material consisted of MR and 1H-MRS examinations from 2 patients (4-5 years old) with tuberous sclerosis. MR images (FSE, FAST, FLAIR) were obtained with a 1.5 T unit. Localized 1H-MRS studies (PRESS 35, TE 35 ms, TR 1500 ms, NEX 192) on cortical (n=3) and subependymal (n=1) lesions were also performed.
  
  
  RESULTS
  Decreased N-acatyloaspartate/creatine (NAA/Cr) and increased myoinositol/creatine (mI/Cr) ratios were observed in the spectra obtained from the subcortical and subependymal tubers.
  
  
  CONCLUSIONS
  Our observations confirm the hypothesis that disturbances of migration, adhesion and differentiation of germ neuronal cells may underlay the pathogenesis of tuberous sclerosis.
authors: Department of Radiology, Medical University Hospital, Bialystok, Poland.
authors: E
authors: E
authors: Tarasów
authors: B
authors: B
authors: Kubas
authors: J
authors: J
authors: Walecki
mesh_terms: D002493:Central Nervous System Diseases / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D014402:Tuberous Sclerosis / Q000473:pathology*