Recombinant human interleukin-6 induces hepatocyte growth factor production in cancer patients.
BACKGROUND
Experiments in animals demonstrate an important role for interleukin-6 (IL-6) in liver regeneration. It is suggested that IL-6 initiates hepatocyte growth factor (HGF) synthesis.


METHODS
The aim of the study was to examine the effect of exogenously administered recombinant human IL-6 (rhIL-6), in doses of 0.5, 1.0, 2.5, 5, 10 and 20 micrograms/kg/day, on HGF serum levels in humans. Serum HGF levels were measured on days 1, 2, 3, 8 and 15 and were correlated with serum amyloid A (SAA) and C-reactive protein (CRP).


RESULTS
Median HGF levels increased to 124% at day 3 (P < 0.05) and 157% (P < 0.05) at day 8 as compared to 100% levels at day 1. An IL-6 dose-dependent increase in HGF was found at day 8 (R = 0.53, P < 0.02). The percentual change in serum HGF level at day 8 correlated with IL-6 serum levels at day 1 R = 0.59, P < 0.01). HGF levels did not correlate with CRP and SAA.


CONCLUSIONS
In humans, rhIL-6 administration resulted in an increase in serum HGF levels.
de Jong
K P
KP
Division of HPB Surgery and Liver Transplantation, University Hospital, P.O. Box 30001, 9700 RB Groningen, The Netherlands. k.p.de.jong@chir.azg.nl
van Gameren
M M
MM
Bijzet
J
J
Limburg
P C
PC
Sluiter
W J
WJ
Slooff
M J
MJ
de Vries
E G
EG
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism; D002097:C-Reactive Protein / Q000378:metabolism; D002289:Carcinoma, Non-Small-Cell Lung / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D017228:Hepatocyte Growth Factor / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D015850:Interleukin-6 / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use*; D000685:Serum Amyloid A Protein / Q000378:metabolism
D015850:Interleukin-6; D011994:Recombinant Proteins; D000685:Serum Amyloid A Protein; D017228:Hepatocyte Growth Factor; D002097:C-Reactive Protein