Treatment of ocular toxocariasis with albendazole.
The purpose of this study was to evaluate the efficacy of combined albendazole and steroid treatment for uveitis caused by Toxocara canis in immunocompetent patients. Five patients (7 eyes) with ocular larva migrans syndrome (OLM) were used in this study. Toxocariasis was suspected based on clinical manifestations and confirmed by anti-toxocara IgG and Western blot analysis. Systemic albendazole (adults: 800 mg b.i.d.; children: 400 mg b.i.d.) was given in conjunction with steroids. Visual acuity before and after therapy, inflammatory response, side effects and toxicity were evaluated. Treatment resulted in an improved visual acuity in all patients. Mean initial Snellen visual acuity was 20/40, and mean final acuity was 20/20. There were no recurrences of uveitis throughout the observation period (average: 13.8 months; range: 3 days to 24 months). These findings suggest that albendazole, in combination with systemic steroids, is a useful regimen to treat ocular larva migrans syndrome.
Barisani-Asenbauer
T
T
Department of Ophthalmology, University of Vienna Medical School, Austria. talin.barisani@akh-wien.ac.at
Maca
S M
SM
Hauff
W
W
Kaminski
S L
SL
Domanovits
H
H
Theyer
I
I
Auer
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D015766:Albendazole / Q000627:therapeutic use; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D015153:Blotting, Western; D002648:Child; D004359:Drug Therapy, Combination; D015822:Eye Infections, Parasitic / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use*; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D014119:Toxocara / Q000276:immunology; D014120:Toxocariasis / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D016896:Treatment Outcome; D015866:Uveitis, Posterior / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology; D014792:Visual Acuity
D000909:Antibodies, Helminth; D000981:Antiprotozoal Agents; D005938:Glucocorticoids; D007074:Immunoglobulin G; D011239:Prednisolone; D015766:Albendazole