title: First synthesis of totally orthogonal protected alpha-(trifluoromethyl)- and alpha-(difluoromethyl)arginines.
abstract: The first synthesis of a series of totally orthogonal protected racemic alpha-(trifluoromethyl)- and alpha-(difluoromethyl)arginines is described. The key steps of the synthesis are the mild guanidinylation procedure and the selective hydrogenation of a CC triple bond in the presence of a Cbz-group.
authors: Institute of Organic Chemistry, University of Leipzig, Johannisallee 29, D-04103 Leipzig, Germany. moroni@organik.chemie.uni-leipzig.de
authors: M
authors: M
authors: Moroni
authors: B
authors: B
authors: Koksch
authors: S N
authors: SN
authors: Osipov
authors: M
authors: M
authors: Crucianelli
authors: M
authors: M
authors: Frigerio
authors: P
authors: P
authors: Bravo
authors: K
authors: K
authors: Burger
mesh_terms: D001120:Arginine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry; D002855:Chromatography, Thin Layer; D006146:Guanidines / Q000737:chemistry; D006865:Hydrogenation; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy
chemical_list: C431668:(trifluoromethyl)arginine; D006146:Guanidines; D007202:Indicators and Reagents; C030965:alpha-(difluoromethyl)arginine; D001120:Arginine