Enantioselective rhodium(I)-catalyzed hydrogenation of trifluoromethyl ketones.
[figure: see text] The asymmetric hydrogenation of trifluoromethyl ketones to yield chiral alpha-trifluoromethyl alcohols with enantiomeric excesses up to 98% was achieved in the presence of chiral rhodium-(amidephosphine-phosphinite) complexes.
Kuroki
Y
Y
Chemical Division, Daikin Industries, Ltd., Miyukigaoka, Tsukuba, Ibaraki 305-0841, Japan. yoshichika.kuroki@daikin.co.jp
Sakamaki
Y
Y
Iseki
K
K
D000438:Alcohols / Q000138:chemical synthesis*; D006845:Hydrocarbons, Fluorinated / Q000138:chemical synthesis* / Q000737:chemistry; D006859:Hydrogen / Q000737:chemistry; D007659:Ketones / Q000737:chemistry*; D012238:Rhodium / Q000737:chemistry*; D013237:Stereoisomerism
D000438:Alcohols; D006845:Hydrocarbons, Fluorinated; D007659:Ketones; D006859:Hydrogen; D012238:Rhodium