title: [Macroscopic and microscopic study of the right coronary artery after radiofrequency catheter ablation of cavotricuspid isthmus in an experimental model].
abstract: OBJECTIVE
  The right coronary artery (RCA) is found in the AV groove, just below the ablation target of atrial flutter, the cavotricuspid isthmus (ICT). After radiofrequency (RF) ablation with standard catheters, there have been no reports of complications, but it may not be successful in 10% of the cases. However, the use of irrigated tip catheters, which create deeper lesions, might potentially damage the coronary tree.
  
  
  METHODS
  We analyzed the effects of ICT RF ablation on the coronary tree, with macroscopic and microscopic anatomopathological study. Ablation on ICT was performed using an irrigated tip catheter in 16 pigs and was randomly compared with a standard ablation catheter. There were no clinical problems, modifications of ST or new arrhythmias during the ablation. The heart was extracted at 1 week.
  
  
  RESULTS
  The macroscopic study demonstrated that the right coronary artery was preserved, along the ICT, surrounded by the epicardial fat. The microscopic study showed an inflammatory reaction in the epicardial fat that reached the adventitia of the coronary artery, but never produced necrosis in 14 cases. The muscular wall of the artery had signs of focal inflammation without endothelium involvement in 2 cases. However, we found a subepicardial vein completely damaged by the radiofrequency.
  
  
  CONCLUSIONS
  Although the right coronary artery is located just below the isthmus, no necrosis was observed in any case. However, there was an inflammatory reaction that focally reached the muscular wall. The veins may be damaged in RF ablation, perhaps due to the different blood flow of each vessel.
authors: Servicio de Cardiología. Unidad de Arritmias Departamento de Medicina. Universidad de Alcalá. Madrid.
authors: A H
authors: AH
authors: Madrid
authors: J M
authors: JM
authors: González Rebollo
authors: J M
authors: JM
authors: Del Rey
authors: G
authors: G
authors: Peña
authors: A
authors: A
authors: Camino
authors: C
authors: C
authors: Vázquez
authors: F
authors: F
authors: Palacios
authors: M
authors: M
authors: García-Cosío
authors: A
authors: A
authors: Socas
authors: C
authors: C
authors: Correa
authors: A O
authors: AO
authors: Chércoles
authors: A
authors: A
authors: Palmeiro Uriach
authors: C
authors: C
authors: Moro
mesh_terms: D000818:Animals; D001283:Atrioventricular Node; D006328:Cardiac Catheterization; D017115:Catheter Ablation; D002404:Catheterization; D003331:Coronary Vessels / Q000473:pathology* / Q000601:surgery*; D006346:Heart Septum / Q000473:pathology / Q000601:surgery*; D013552:Swine