Phylogenetic reconstruction of intrapatient evolution of human immunodeficiency virus type 1: predominance of drift and purifying selection.
The intra-host evolution of 73 human immunodeficiency virus type 1 quasispecies was analysed by split decomposition analysis. Non-synonymous and synonymous nucleotide substitutions were counted along the shortest path connecting all sequences and compared with the numbers expected under the assumption of a random model of mutation. For the majority of substitutions, drift and negative selection seemed to prevail.
Kils-Hütten
Laurens
L
Abteilung Virologie, Universität des Saarlandes, Institut für Medizinische Mikrobiologie und Hygiene, Klinikum Homburg, Haus 47, D-66421 Homburg, Germany1.
Cheynier
Rémi
R
Unité de Rétrovirologie Moléculaire, Institut Pasteur, F-75724 Paris cedex 15, France2.
Wain-Hobson
Simon
S
Unité de Rétrovirologie Moléculaire, Institut Pasteur, F-75724 Paris cedex 15, France2.
Meyerhans
Andreas
A
Abteilung Virologie, Universität des Saarlandes, Institut für Medizinische Mikrobiologie und Hygiene, Klinikum Homburg, Haus 47, D-66421 Homburg, Germany1.
D005075:Biological Evolution; D005787:Gene Frequency; D015752:Genes, env; D015750:Genes, gag; D015754:Genes, nef; D015658:HIV Infections / Q000821:virology*; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D013997:Time Factors