Regulation of mast cell survival by IgE.
Mast cells play critical roles in hypersensitivity and in defense against certain parasites. We provide evidence that mouse mast cell survival and growth are promoted by monomeric IgE binding to its high-affinity receptor, Fc epsilon RI. Monomeric IgE does not promote DNA synthesis but suppresses the apoptosis induced by growth factor deprivation. This antiapoptotic effect occurs in parallel with IgE-induced increases in Fc epsilon RI surface expression but requires the continuous presence of IgE. This process does not involve the FasL/Fas death pathway or several Bcl-2 family proteins and induces a distinctly different signal than Fc epsilon RI cross-linking. The ability of IgE to enhance mast cell survival and Fc epsilon RI expression may contribute to amplified allergic reactions.
Asai
K
K
Division of Allergy, La Jolla Institute for Allergy and Immunology, 10355 Science Center Drive, San Diego, CA 92121, USA.
Kitaura
J
J
Kawakami
Y
Y
Yamagata
N
N
Tsai
M
M
Carbone
D P
DP
Liu
F T
FT
Galli
S J
SJ
Kawakami
T
T
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D002455:Cell Division; D002470:Cell Survival; D003432:Cross-Linking Reagents; D053222:Fas Ligand Protein; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology; D007073:Immunoglobulin E / Q000276:immunology* / Q000494:pharmacology; D007377:Interleukin-3 / Q000276:immunology / Q000494:pharmacology; D007424:Intracellular Fluid / Q000276:immunology; D008407:Mast Cells / Q000166:cytology / Q000187:drug effects / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000276:immunology; D017455:Receptors, IgE / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*; D019014:fas Receptor / Q000276:immunology
D003432:Cross-Linking Reagents; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D006133:Growth Substances; D007377:Interleukin-3; D008562:Membrane Glycoproteins; D019253:Proto-Oncogene Proteins c-bcl-2; D017455:Receptors, IgE; D019014:fas Receptor; D007073:Immunoglobulin E