[Antifungal susceptibility of emerging yeast pathogens].
BACKGROUND
To study the antifungal susceptibility of emerging yeast pathogens to know their possible resistance under the need of applying a treatment.


METHODS
We investigated the in vitro susceptibility of 69 yeast strains isolates of clinical samples, belonging to 24 different species, to amphotericin B, fluconazole, itraconazole, ketoconazole and 5-fluorocytosine.


RESULTS
Only 9 species showed susceptibility to all antifungal agents: Candida famata, C. guillermondii, C. holmii, C. kefyr, C. pelliculosa, C. rugosa, C. utilis, C. zeylanoides y Trichosporon cutaneum; the rest of them presented resistance to some antifungal agent. C. haemulonii, Pichia farinosa and Trichosporon mucoides were resistant to amphotericin B; C. haemulonii, C. inconspicua, C. lusitaniae, C. norvegensis, C. pintolepesii, C. valida, P. ohmeri, Rhodotorula glutinis, R. minuta, R. mucilaginosa and Saccharomyces cerevisiae were resistant to azoles; Blastoschizomyces capitatus and C. lipolytica were resistant to 5-fluorocytosine.


CONCLUSIONS
The resistance of emerging yeast pathogens to amphotericin B and 5-fluorocytosine is low, while resistance to azoles is significative, especially to fluconazole (36%). Many of this yeasts present problems of intrinsic resistance. In yeast infections, the correct identification of species and the study of the in vitro susceptibility is important in order to choose the most adequate antifungal treatment.
García-Martos
P
P
Hospital Universitario Puerta del Mar. Cádiz.
Domínguez
I
I
Marín
P
P
García-Agudo
R
R
Aoufi
S
S
Mira
J
J
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D021821:Communicable Diseases, Emerging / Q000382:microbiology; D004352:Drug Resistance, Microbial; D015725:Fluconazole / Q000494:pharmacology; D005437:Flucytosine / Q000494:pharmacology; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000382:microbiology; D010843:Pichia / Q000187:drug effects; D012248:Rhodotorula / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013045:Species Specificity; D014250:Trichosporon / Q000187:drug effects; D015003:Yeasts / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification
D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B; D015725:Fluconazole; D005437:Flucytosine; D007654:Ketoconazole