Effect of fructose-1, 6-diphosphate versus diphenhydramine on mortality in compound 48/80-induced shock.
Fructose-1,6-diphosphate (FDP) has a salutary effect on hemorrhagic, traumatic and endotoxic shock. The role of FDP on compound 48/80-induced shock was therefore investigated. Sprague Dawley aged male rats (448+/-7.4 gm body weight) were randomly assigned into three groups and treated intraperitoneally with diphenhydramine (DPHM) 15 mg/kg (n=11), 12.5 ml of 10% FDP (n=10) and 12.5 ml saline (n=10). The rats were injected with compound 48/80 (5 mg/kg) 30 min later, and monitored every 10 min for 60 min. Arterial pressure was higher in FDP rats than in DPHM (P<0.01) or saline (P<0.005) groups. Plasma potassium (K(+)) was lower in the FDP group (P<0.01). Arterial pO2 and pCO2 were within physiological range in all groups. A profound decrease in arterial pH and bicarbonate (HCO3(-)) was also observed in all groups. Mortality at 48 h in the saline group was 100%, in the DPHM group 91%, and in the FDP group 20% (P<0.001 and P<0.005, respectively). FDP improved survival significantly in this study.
Figueroa
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Department of Medicine, Division of Cardiovascular Diseases, University of Mississippi Medical Center, 2500 North State Street, Jackson, MS 39216-4505, USA.
Stone
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Cohly
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Lehan
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Markov
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D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004155:Diphenhydramine / Q000627:therapeutic use*; D005635:Fructosediphosphates / Q000627:therapeutic use*; D008297:Male; D011188:Potassium / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012769:Shock / Q000188:drug therapy* / Q000401:mortality / Q000517:prevention & control; D003189:p-Methoxy-N-methylphenethylamine / Q000633:toxicity*
D005635:Fructosediphosphates; D003189:p-Methoxy-N-methylphenethylamine; D004155:Diphenhydramine; D000255:Adenosine Triphosphate; C029063:fructose-1,6-diphosphate; D011188:Potassium