title: Spatial and temporal control of RNA stability.
abstract: Maternally encoded RNAs and proteins program the early development of all animals. A subset of the maternal transcripts is eliminated from the embryo before the midblastula transition. In certain cases, transcripts are protected from degradation in a subregion of the embryonic cytoplasm, thus resulting in transcript localization. Maternal factors are sufficient for both the degradation and protection components of transcript localization. Cis-acting elements in the RNAs convert transcripts progressively (i) from inherently stable to unstable and (ii) from uniformly degraded to locally protected. Similar mechanisms are likely to act later in development to restrict certain classes of transcripts to particular cell types within somatic cell lineages. Functions of transcript degradation and protection are discussed.
authors: Program in Developmental Biology, Research Institute, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, ON M5G 1X8, Canada. lipshitz@sickkids.on.ca
authors: A
authors: A
authors: Bashirullah
authors: R L
authors: RL
authors: Cooperstock
authors: H D
authors: HD
authors: Lipshitz
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D001755:Blastocyst / Q000502:physiology; D017124:Conserved Sequence; D004330:Drosophila / Q000196:embryology / Q000235:genetics; D005260:Female; D018392:Genomic Imprinting; D008297:Male; D012313:RNA / Q000737:chemistry / Q000235:genetics*; D014158:Transcription, Genetic
chemical_list: D012313:RNA