title: [Autoimmune hepatitis associated with mixed connective tissue disease: report of a case and a review of the literature].
abstract: A case is reported of a 29 year old female who had autoimmune hepatitis associated with mixed connective tissue disease (MCTD). The patient developed MCTD at the age of 19, and was treated with prednisolone. Liver dysfunction developed 7 years later, which exacerbated shortly after the patient suffered intrauterine fetal death during the second trimester of pregnancy. Laboratory data showed negative anti-hepatitis C antibody and hepatitis B antigen, but positive anti-smooth muscle antibody. A liver biopsy showed chronic active hepatitis. Referring to the criteria we diagnosed her as having autoimmune hepatitis. Although hepatomegaly is sometimes observed in MCTD patients, only 5 cases of autoimmune hepatitis associated with MCTD have been reported in the past. In our case, it is of note that autoimmune hepatitis developed while symptoms of MCTD were in remission, and that autoimmune hepatitis exacerbated with the emergence of anti-smooth muscle antibody following the termination of pregnancy.
authors: Department of Internal Medicine, Saga Medical School.
authors: S
authors: S
authors: Aoki
authors: Y
authors: Y
authors: Tada
authors: A
authors: A
authors: Ohta
authors: S
authors: S
authors: Koarada
authors: O
authors: O
authors: Ushiyama
authors: N
authors: N
authors: Suzuki
authors: K
authors: K
authors: Nagasawa
mesh_terms: D000328:Adult; D005260:Female; D005313:Fetal Death / Q000276:immunology; D019693:Hepatitis, Autoimmune / Q000209:etiology*; D006801:Humans; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000276:immunology; D011247:Pregnancy