Lipid rafts and signal transduction.
Signal transduction is initiated by complex protein-protein interactions between ligands, receptors and kinases, to name only a few. It is now becoming clear that lipid micro-environments on the cell surface -- known as lipid rafts -- also take part in this process. Lipid rafts containing a given set of proteins can change their size and composition in response to intra- or extracellular stimuli. This favours specific protein-protein interactions, resulting in the activation of signalling cascades.
Simons
K
K
Max Planck Institute for Molecular Cell Biology and Genetics, Pfotenhauerstrasse 110, D-01307 Dresden, Germany. Simons@EMBL-Heidelberg.de
Toomre
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D
D000818:Animals; D021941:Caveolae / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D004705:Endocytosis / Q000502:physiology; D021962:Membrane Microdomains / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D015394:Molecular Structure; D010743:Phospholipids / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013107:Sphingolipids / Q000378:metabolism
D010743:Phospholipids; D011956:Receptors, Cell Surface; D013107:Sphingolipids; D002784:Cholesterol