Urinary PGE(2) concentrations measured by a new EIA method in infants with urinary tract infections or renal malformations.
In this work PGE(2)concentrations were measured by a new EIA method in the urine of infants (mean age: 9.35+/-4.24 months) with recurrent urinary tract infections or renal malformations. Compared to healthy subjects, PGE(2)excretion rates resulted significantly higher in both pathological groups, in particular in subjects with obstructive uropathies (29.55+/-8.12 vs 18.37+/-4.64 pg/ml). We did not find any age- or pH-dependent difference in urinary excretion of PGE(2); none of the examined indices of renal function showed any significant relationship to PGE(2). These results suggest that this parameter, measured non-invasively in the urine, could help in the differential diagnosis between obstructive vs non-obstructive dilatation and in monitoring renal function in presence of recurrent UTI episodes.
Cuzzolin
L
L
Department of Medicine & Public Health--Section of Pharmacology, University of Verona, Policlinico Borgo Roma, 37134 Verona, Italy. lcuzzolin@univr.it
Mangiarotti
P
P
Fanos
V
V
D000367:Age Factors; D015415:Biomarkers / Q000652:urine; D016022:Case-Control Studies; D015232:Dinoprostone / Q000652:urine*; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007124:Immunoenzyme Techniques / Q000379:methods / Q000592:standards*; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities* / Q000378:metabolism; D016014:Linear Models; D008297:Male; D012008:Recurrence; D014552:Urinary Tract Infections / Q000652:urine*
D015415:Biomarkers; D015232:Dinoprostone