Hypodynamia--hypokinesia induced variations in expression of fos protein in structures related to somatosensory system in the rat.
There have been many reports describing modifications of the sensory and motor cortex following various types of disuse. Hypodynamia--hypokinesia is characterized by the absence of weight-bearing and by a decrease in motor activity. We have shown a reorganization of the cortical cartography after hypodynamia--hypokinesia. In order to give an anatomical account for this cortical plasticity, we set out to determine whether cerebral and spinal structures exhibited variations of their neuronal activation. For this purpose, immunocytochemical detection of Fos protein was performed in the rat brain and spinal cord. Following stimulation of the sciatic nerve, Fos protein was detected in the primary and secondary somatosensory cortex in control rats and in rats submitted to an episode of 14 days of hypodynamia--hypokinesia. Results showed that the stimulation of the sciatic nerve induced an increase in the number of Fos-immunoreactive neurons in all these structures. Moreover, after hypodynamia--hypokinesia, the number of Fos-immunoreactive neurons was increased in the primary and secondary somatosensory cortex and in the spinal cord. These results provide evidence for a higher activation of cortical cells after hypodynamia--hypokinesia in comparison to controls. These data support the hypothesis that hypodynamia--hypokinesia contributes to the development of functional plasticity.
Langlet
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C
Laboratoire de Plasticité Neuromusculaire, Université des Sciences et Technologies de Lille, Bâtiment SN4, F-59655 Villeneuve d'Ascq Cedex, France.
Canu
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MH
Viltart
O
O
Sequeira
H
H
Falempin
M
M
D000818:Animals; D002452:Cell Count; D004558:Electric Stimulation; D018476:Hypokinesia / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D007103:Immobilization / Q000009:adverse effects / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D009473:Neuronal Plasticity / Q000502:physiology*; D020671:Posterior Horn Cells / Q000166:cytology / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000502:physiology; D012677:Sensation / Q000502:physiology; D012683:Sensory Deprivation / Q000502:physiology*; D013003:Somatosensory Cortex / Q000166:cytology / Q000378:metabolism*
D016760:Proto-Oncogene Proteins c-fos