Sequence-selective peptide detection by small synthetic chemosensors selected from an encoded combinatorial chemosensor library.
Synthetic chemosensors hold great potential in many diagnostic applications. In this study, we describe the design and preparation of the first encoded combinatorial library of chemosensors for tripeptides. Subsequent screening of the library resulted in the discovery of novel chemosensors able to distinguish between random tripeptides.
Iorio
E J
EJ
Department of Chemistry, Columbia University, 10027, New York, NY, USA. jedwardsinc@mindspring.com
Shao
Y
Y
Chen
C T
CT
Wagner
H
H
Still
W C
WC
D020650:Combinatorial Chemistry Techniques; D009842:Oligopeptides / Q000032:analysis* / Q000737:chemistry
D009842:Oligopeptides