The beneficial effect of OST-6 (OsteoCare), a herbomineral formulation, in experimental osteoporosis.
OST-6 (OsteoCare), a herbomineral formulation, was evaluated for its inhibitory effect on the progress of bone loss induced by ovariectomy in rats. Ovariectomized (Ovx) rats were administered with OST-6 at 250 and 500 mg/kg b.wt., orally daily for 90 days. On 91st day, ovariectomized rats showed reduced bone mineral content and increased serum alkaline phosphatase levels, excretion of urinary calcium and pyridinium cross-links levels. Histologically, bone sections revealed narrowed and disappearance of trabeculae and widened medullary spaces. The total numbers of Tartrate-resistant acid phosphatase (TRAP) positive cells were significantly increased both in-vivo and in-vitro methods. OST-6, at a dose of 500 mg/kg, significantly improved bone mineral contents, serum alkaline phosphatase levels, reduced the elevated urinary calcium and pyridinium cross-links excretion, number of TRAP positive cells and reversal of the above mentioned histological features. These results indicate the usefulness of OST-6 in the management of osteoporosis in a natural way through herbal resources.
Mitra
S K
SK
Department of Pharmacology, R&D Center, The Himalaya Drug Company, Makali, Bangalore, India. hdcrd@bgl.vsnl.net.in
Venkataranganna
M V
MV
Udupa
U V
UV
Gopumadhavan
S
S
Seshadri
S J
SJ
Rafiq
M
M
Anturlikar
S D
SD
Sundaram
R
R
Tripathi
M
M
D000596:Amino Acids / Q000652:urine; D000818:Animals; D001842:Bone and Bones / Q000737:chemistry / Q000166:cytology; D003404:Creatinine / Q000652:urine; D005260:Female; D007194:India; D008515:Medicine, Ayurvedic; D008903:Minerals / Q000627:therapeutic use; D010006:Osteoblasts / Q000166:cytology; D010010:Osteoclasts / Q000166:cytology; D010024:Osteoporosis / Q000188:drug therapy*; D010052:Ovariectomy; D010936:Plant Extracts / Q000097:blood / Q000627:therapeutic use* / Q000652:urine; D010946:Plants, Medicinal; D011726:Pyridinium Compounds; D051381:Rats; D017207:Rats, Sprague-Dawley
D000596:Amino Acids; D008903:Minerals; C421405:OST-6 preparation; D010936:Plant Extracts; D011726:Pyridinium Compounds; C015484:pyridinoline; C036020:deoxypyridinoline; D003404:Creatinine