Molecular estimates of primate divergences and new hypotheses for primate dispersal and the origin of modern humans.
The concept of recent hominoid divergences has been a mainstay in molecular primatology since the 1970's. However, the ages allocated to the calibration points used to establish these divergence times and the estimates resulting from their application, notably the commonly accepted divergence between Pan (chimpanzees) and Homo 5 million years before present (MYBP), are now palaeontologically refutable. Here we estimate the ages of various primate divergences using three references with a more detailed fossil record than any of the traditional primate calibration points. Our findings suggest that the latter yield datings that are too recent by a factor of about two. For example, our estimates place the divergence between Pan and Homo 10.5-13 MYBP. The revised estimates of primate divergence times suggest a new hypothesis for primate evolution and dispersal: that the divergence between strepsirhines (lorises, lemurs) and anthropoids was contemporary with the break-up of Southern continents about 90 MYBP, with strepsirhines becoming isolated on Madagascar and later dispersing to Africa (and Asia) and anthropoids evolving in South America and subsequently colonizing Africa (and Asia), or possibly North America. In addition we present a new hypothesis, which accommodates the strikingly similar coalescence times for human mitochondrial DNA and the Y-chromosome. This hypothesis posits a common mitochondrial and Y-chromosome bottleneck about 400,000 years ago, associated with the origination of the human 2n = 46 karyotype, obstructing genetic exchange with the 2n = 48 Homo contemporaries.
Arnason
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Department of Genetics, Division of Evolutionary Molecular Systematics, University of Lund, Lund, Sweden. ulfur.arnason@gen.lu.se
Gullberg
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Burguete
A S
AS
Janke
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D000349:Africa; D000818:Animals; D005075:Biological Evolution; D004272:DNA, Mitochondrial / Q000378:metabolism; D005828:Genetics, Population; D006801:Humans; D016013:Likelihood Functions; D010802:Phylogeny; D011323:Primates / Q000235:genetics*; D013020:South America; D013997:Time Factors
D004272:DNA, Mitochondrial