title: Severe hypertension and massive osteoporosis as presenting symptoms of Cushing's syndrome.
abstract: Though Cushing's syndrome is a well-known clinical problem in terms of side effects of steroid therapy, endogenous Cushing's syndrome is a relatively rare diagnosis. We treated a 27-year-old patient who presented with severe hypertension and massive osteoporosis. We could diagnose a central Cushing syndrome by endocrinological function tests which, in retrospect, existed undiagnosed for more than 5 years. However, magnetic resonance imaging did not display an adenoma neither of the hypophysis nor of the adrenal glands. During explorative surgery, a cylindric microadenoma of the pituary gland was found and excised. After surgery, the blood pressure returned to normal, making further antihypertensive treatment unnecessary.
authors: Klinik und Poliklinik für Innere Medizin I und II, Klinikum der Universität Regensburg, Deutschland. Dierk.Endemann@klinik.uni-regenburg.de
authors: D H
authors: DH
authors: Endemann
authors: M
authors: M
authors: Fischereder
authors: T
authors: T
authors: Leingärtner
authors: M
authors: M
authors: Stubanus
authors: B
authors: B
authors: Zietz
authors: G A
authors: GA
authors: Riegger
authors: B K
authors: BK
authors: Krämer
mesh_terms: D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000328:Adult; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D010024:Osteoporosis / Q000150:complications*; D010902:Pituitary Gland / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications* / Q000601:surgery