Combined treatment with calcipotriol ointment and low-dose ultraviolet A1 phototherapy in childhood morphea.
Various therapies for morphea have been used with limited success, including ones with potentially hazardous side effects. When morphea occurs in childhood it may lead to progressive and long-lasting induration of the skin and subcutaneous tissue, growth retardation, and muscle atrophy. We report an open prospective study in which the efficacy of a combined treatment with calcipotriol ointment and low-dose ultraviolet A1 (UVA1) phototherapy in childhood morphea was investigated. Nineteen children (mean age 8.5 years, range 3-13 years) with morphea were exposed to UVA1 (340-400 nm) phototherapy at a dose of 20 J/cm(2) four times a week for 10 weeks. Forty phototherapy sessions resulted in a cumulative dose of 800 J/cm(2) UVA1. In addition, calcipotriol ointment (0.005%) was applied twice a day. After 10 weeks, palpation and inspection showed a remarkable softening and repigmentation of formerly affected skin resulting in a highly significant (p < 0.001) decrease of the mean clinical score from 7.3 +/- 0.9 at the beginning to 2.4 +/- 0.9 (relative reduction 67.1%) at the end of combined therapy. Our results indicate that a combined therapy with calcipotriol ointment and low-dose UVA1 phototherapy is highly effective in childhood morphea. Further controlled studies are necessary to investigate whether this combined therapy is superior to UVA1 phototherapy alone.
Kreuter
A
A
Department of Dermatology, Ruhr-University Bochum, Bochum, Germany. a.kreuter@derma.de
Gambichler
T
T
Avermaete
A
A
Jansen
T
T
Hoffmann
M
M
Hoffmann
K
K
Altmeyer
P
P
von Kobyletzki
G
G
Bacharach-Buhles
M
M
D000293:Adolescent; D002117:Calcitriol / Q000008:administration & dosage* / Q000031:analogs & derivatives; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003879:Dermatologic Agents / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D009824:Ointments; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D012594:Scleroderma, Localized / Q000473:pathology / Q000628:therapy*; D012867:Skin / Q000473:pathology; D014467:Ultraviolet Therapy
D003879:Dermatologic Agents; D009824:Ointments; C055085:calcipotriene; D002117:Calcitriol