Pathogenicity islands: the tip of the iceberg.
Pathogenicity islands represent distinct genetic elements encoding virulence factors of pathogenic bacteria. Pathogenicity islands belong to the class of genomic islands, which are common genetic elements sharing a set of unifying features. Genomic islands have been acquired by horizontal gene transfer. In recent years many different genomic islands have been discovered in a variety of pathogenic as well as non-pathogenic bacteria. Because they promote genetic variability, genomic islands play an important role in microbial evolution.
Hentschel
U
U
Institut für Molekulare Infektionsbiologie, Universität Würzburg, Röntgenring 11, 97070 Würzburg, Germany.
Hacker
J
J
D000818:Animals; D001419:Bacteria / Q000235:genetics* / Q000472:pathogenicity*; D001483:Base Sequence; D004463:Ecology; D019143:Evolution, Molecular; D022761:Gene Transfer, Horizontal; D014644:Genetic Variation / Q000235:genetics; D016680:Genome, Bacterial; D006801:Humans; D014774:Virulence / Q000235:genetics