Neural substrates for recognition of familiar voices: a PET study.
Identification of familiar people is essential in our social life. We can identify familiar people by hearing their voices as well as by viewing their faces. By measuring regional cerebral blood flow (rCBF) by positron emission tomography (PET), we identified neural substrates for the recognition of familiar voices. The brain activity during discrimination of voices of the subjects' associates and friends from those of unfamiliar people was compared with that during an analogous discrimination of their own voice from unfamiliar voices as well as during vowel discrimination. The left frontal pole, right temporal pole, right entorhinal cortex, and left precuneus were activated to a greater extent during discrimination of familiar voice than during control discriminations, suggesting that these brain regions are involved in the recognition of familiar voices. Furthermore, the adjusted values of rCBF in the left frontal pole and right temporal pole correlated with the number of subjects' correct identification of familiar voices. The present results suggest that these two regions are coactively associated with matching the currently heard voice to familiar voices in one's memory.
Nakamura
K
K
Department of Behavioral and Brain Sciences, Primate Research Institute, Kyoto University, Kanrin, Inuyama, Aichi 484-8506, Japan. knakamur@pri.kyoto-u.ac.jp
Kawashima
R
R
Sugiura
M
M
Kato
T
T
Nakamura
A
A
Hatano
K
K
Nagumo
S
S
Kubota
K
K
Fukuda
H
H
Ito
K
K
Kojima
S
S
D000328:Adult; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D018728:Entorhinal Cortex / Q000098:blood supply / Q000000981:diagnostic imaging; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D011939:Mental Recall / Q000502:physiology*; D012039:Regional Blood Flow / Q000502:physiology; D013061:Speech Acoustics; D013067:Speech Perception / Q000502:physiology*; D013702:Temporal Lobe / Q000098:blood supply / Q000000981:diagnostic imaging; D014055:Tomography, Emission-Computed