New bioactive sulfated metabolites from the Mediterranean tunicate Sidnyum turbinatum.
In addition to the known sodium 3,7,11,15-tetramethylhexadeca-1,19-diyl sulfate (4), the BuOH extract of the Mediterranean tunicate Sidnyum turbinatum was shown to contain four new metabolites: 1-heptadecanyl sulfate (1), 1-octadecanyl sulfate (2), sodium (2S)-2,6,10,14-tetramethylpentadeca-1,18-diyl sulfate (3), and 1-hexyl sulfate (5). Their structures were determined by spectroscopic and chemical methods. Compounds 1-5 exhibited in vitro antiproliferative activity estimated on the WEHI 164 cell line.
Aiello
A
A
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Federico II, Via D. Montesano 49, I-80131, Napoli, Italy.
Carbonelli
S
S
Fattorusso
E
E
Iuvone
T
T
Menna
M
M
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005354:Fibrosarcoma / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D015122:Mercaptopurine; D051379:Mice; D008956:Models, Chemical; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013431:Sulfates / Q000378:metabolism* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000737:chemistry / Q000378:metabolism*
D013431:Sulfates; D015122:Mercaptopurine