title: Effect of disaggregation on calpain activity in explants from rat thyroid glands.
abstract: We studied the regulation of calpains in explants from rat thyroid glands. Collagenase disaggregation decreased proteinase activity in thyrocytes. It was hypothesized that this effect is mediated by heterotrimeric G proteins, protein kinase C, and tyrosine kinase, but not via Ca(2+) and cAMP-dependent signal pathway.
authors: Department of Biochemistry, I. P. Pavlov Ryazan State Medical University.
authors: E A
authors: EA
authors: Stroev
authors: V G
authors: VG
authors: Makarova
authors: E A
authors: EA
authors: Ryazanova
authors: I V
authors: IV
authors: Plyakhin
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D002154:Calpain / Q000378:metabolism*; D000242:Cyclic AMP / Q000378:metabolism; D020962:Heterotrimeric GTP-Binding Proteins / Q000502:physiology; D066298:In Vitro Techniques; D008297:Male; D011493:Protein Kinase C / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction; D013961:Thyroid Gland / Q000166:cytology / Q000201:enzymology*
chemical_list: D000242:Cyclic AMP; D011505:Protein-Tyrosine Kinases; D011493:Protein Kinase C; D002154:Calpain; D020962:Heterotrimeric GTP-Binding Proteins; D002118:Calcium