Selective inhibition of CTL activation by a dipalmitoyl-phospholipid that prevents the recruitment of signaling molecules to lipid rafts.
Legler
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DF
Institute of Biochemistry and. Ludwig Institute for Cancer Research, Lausanne Branch, University of Lausanne, BIL Biomedical Research Center, CH-1066 Epalinges, Switzerland. daniel.legler@ib.unil.ch
Doucey
M A
MA
Cerottini
J C
JC
Bron
C
C
Luescher
I F
IF
D000818:Animals; D020404:Glycerophospholipids / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D021962:Membrane Microdomains / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D010714:Phosphatidylethanolamines / Q000494:pharmacology*; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000187:drug effects* / Q000502:physiology; D014407:Tumor Cells, Cultured
C410262:1,2-dioleoyl-glycero-3-phosphatidyl ethanolamine; D020404:Glycerophospholipids; D010714:Phosphatidylethanolamines; C007510:1,2-dipalmitoyl-3-phosphatidylethanolamine