Toward the creation of NMR databases in chiral solvents for assignments of relative and absolute stereochemistry: scope and limitation.
[structure: see text] Three additional NMR databases, 1-3, in a chiral solvent are presented. The C.21-C.38 portion of oasomycin A is used to demonstrate the scope and limitation of the universal NMR database approach in a chiral solvent for assignment of relative and absolute stereochemistry without degradation and/or derivatization.
Hayashi
N
N
Department of Chemistry and Chemical Biology, Harvard University, 12 Oxford Street, Cambridge, Massachusetts 02138, USA.
Kobayashi
Y
Y
Kishi
Y
Y
D000438:Alcohols / Q000737:chemistry*; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D001596:Benzylamines / Q000737:chemistry*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D016208:Databases, Factual; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D012997:Solvents; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000438:Alcohols; D000900:Anti-Bacterial Agents; D001596:Benzylamines; D018942:Macrolides; D012997:Solvents; C410709:oasomycin; C045966:N-benzyl-N,N-dimethylamine