title: Re-evaluation of ivermectin efficacy against equine gastrointestinal parasites.
abstract: Two trials were conducted to confirm the efficacy of ivermectin paste against endoparasites of horses. In these trials, 20 ponies were treated with ivermectin oral paste at 200 mcg x kg body weight once on Day 0, and 20 ponies served as unmedicated controls. The animals carried naturally acquired parasite infections as confirmed by pretrial fecal examination. The animals were necropsied for worm recovery on Days 14, 15 or 16. Parasites recovered were identified to species. Horses treated with ivermectin had significantly (P<0.05) fewer (>99.0% reduction) adult small strongyles (Coronocyclus spp including C. coronatus, C. labiatus, C. labratus; Cyathostomum spp including C. catinatum, C. pateratum; Cylicocyclus spp including C. ashworthi, C. elongatus, C. insigne, C. leptostomum, C. nassatus, C. radiatus; Cylicodontophorus bicoronatus; Cylicostephanus spp including C. asymetricus, C. bidentatus, C. calicatus, C. goldi, C. longibursatus, C. minutus; Gyalocephalus capitatus; Parapoteriostomum spp including P. euproctus, P. mettami; Petrovinema poculatum; Poteriostomum spp including P. imparidentatum, P. ratzii) and adult large strongyles (Strongylus edentatus, S. vulgaris; Triodontophorus spp including T. brevicauda, T. serratus; Craterostomum acuticaudatum) than the controls. Ivermectin was also highly effective (94% to >99%, P<0.05-0.01) against Gasterophilus intestinalis larvae, Habronema spp., Oxyuris equi, Parascaris equorum. The data from these two trials confirm that ivermectin paste administered to horses orally at 200mcg x kg(-1) continues to be highly effective for treatment and control of a broad range of small and large strongyle species as well as other species of gastrointestinal parasites.
authors: Department of Veterinary Science, Louisiana Agricultural Experiment Station, Louisiana State University-Agriculture Center, Baton Rouge, LA 70803, USA. klei@vetmed.lsu.edu
authors: T R
authors: TR
authors: Klei
authors: S
authors: S
authors: Rehbein
authors: M
authors: M
authors: Visser
authors: W K
authors: WK
authors: Langholff
authors: M R
authors: MR
authors: Chapman
authors: D D
authors: DD
authors: French
authors: P
authors: P
authors: Hanson
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004064:Digestive System / Q000469:parasitology*; D005243:Feces / Q000469:parasitology; D005260:Female; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000517:prevention & control / Q000662:veterinary*; D006734:Horse Diseases / Q000188:drug therapy / Q000517:prevention & control*; D006736:Horses; D007559:Ivermectin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D010273:Parasitic Diseases, Animal / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D000981:Antiprotozoal Agents; D007559:Ivermectin