In vitro comparison of the antimycotic activity of a miconazole-HP-beta-cyclodextrin solution with a miconazole surfactant solution.
The antimycotic activity of a new parenteral solution containing miconazole was compared with that of a marketed solution (Daktarin IV solution). This solution has been withdrawn from the Belgian market, probably because of toxic effects related to the presence of polyoxyl 35 castor oil. We propose a new formulation containing miconazole (10 mg/mL) (like the marketed solution), in combination with hydroxypropyl-beta-cyclodextrin and lactic acid. The MICs of these two solutions were determined by a broth microdilution method (based on NCCLS guidelines) for 67 yeasts and 50 filamentous fungi isolates. This study shows that the MICs obtained with these two solutions are not significantly different.
Piel
G
G
Laboratoires de Technologie Pharmaceutique and Laboratoire de Microbiologie Médicale, Institut de Pharmacie, Université de Liège, Belgium. Geraldine.Piel@ulg.ac.be
Hayette
M P
MP
Pavoni
E
E
Evrard
B
B
Van Hees
T
T
de Hassonville
S H
SH
De Mol
P
P
Delattre
L
L
D000073738:2-Hydroxypropyl-beta-cyclodextrin; D000935:Antifungal Agents / Q000494:pharmacology*; D003505:Cyclodextrins / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D008825:Miconazole / Q000008:administration & dosage / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013501:Surface-Active Agents / Q000494:pharmacology*; D047392:beta-Cyclodextrins
D000935:Antifungal Agents; D003505:Cyclodextrins; D013501:Surface-Active Agents; D047392:beta-Cyclodextrins; D000073738:2-Hydroxypropyl-beta-cyclodextrin; D008825:Miconazole; D004121:Dimethyl Sulfoxide