Estrogen receptor- and aromatase-deficient mice provide insight into the roles of estrogen within the ovary and uterus.
Estrogen receptor (ER)- (alpha, beta, and both alpha and beta) and aromatase (Ar) knockout (KO) mice have been created to assess the biological effects of estrogens. This review article discusses the ovarian and uterine phenotypes of these mice. The data obtained have confirmed some older inferences about how the steroid acts, but have also revealed some unexpected aspects of estrogen action. Mol. Reprod. Dev. 59:336-346, 2001.
Rosenfeld
C S
CS
Department of Animal Sciences, University of Missouri, Columbia, Missouri 65211, USA.
Roberts
R M
RM
Lubahn
D B
DB
D000818:Animals; D001141:Aromatase / Q000235:genetics* / Q000378:metabolism; D004967:Estrogens / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D010641:Phenotype; D010802:Phylogeny; D011960:Receptors, Estrogen / Q000235:genetics* / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000502:physiology*
D004967:Estrogens; D011960:Receptors, Estrogen; D001141:Aromatase