OMP gene deletion results in an alteration in odorant quality perception.
To test the hypothesis that odorant quality perception is altered in olfactory marker protein (OMP)-null mice, we trained and tested adult OMP-null and control mice, using a 5-odorant identification confusion matrix task (animal odorant confusion matrix [AOCM]). On average, control and null mice performed the task at equivalent levels. The composite 5 x 5 response matrix from 40 testing sessions for each subject (both OMP-null and control) was compared with that of every other subject, yielding a dissimilarity matrix of AOCM responses. A multidimensional scaling (MDS) analysis of the dissimilarity data yielded a 4-dimensional solution, with each mouse occupying a point in MDS animal space. Statistical analysis demonstrated significant effects of genotype in determining the location of a mouse in the MDS space. These data suggest, therefore, that compared with that of controls, odorant quality perception is altered in the OMP-null mouse.
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Department of Neuroscience and Physiology, State University of New York (SUNY) Upstate Medical University, 750 East Adams Street, Syracuse, New York 13210, USA. youngens@mail.upstate.edu
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D000818:Animals; D002872:Chromosome Deletion; D005819:Genetic Markers / Q000235:genetics; D008297:Male; D051379:Mice; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009812:Odorants; D051842:Olfactory Marker Protein; D012903:Smell / Q000235:genetics* / Q000502:physiology
D005819:Genetic Markers; D009419:Nerve Tissue Proteins; D051842:Olfactory Marker Protein; C497598:Omp protein, mouse