Construction of azaspirocyclic ketones through alpha-hydroxyiminium ion or alpha-siloxy epoxide semipinacol rearrangements.
[reaction: see text] Semipinacol-type rearrangements to produce azaspirocyclic ketones are presented. The yields and stereoselectivities of these reactions range from 67-94% yield and 2.8:1 to 1:0 diastereoselectivity, respectively.
Fenster
M D
MD
Department of Chemistry, 2036 Main Mall, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z1.
Patrick
B O
BO
Dake
G R
GR