title: [Hypothyroidism and myocardial damage in cardiac donors].
abstract: OBJECTIVE
  Brain death may induce myocardial contractile dysfunction and hypothyroidism. This myocardial dysfunction is a limiting factor when considering donor heart for transplantation. Myocardial damage has shown to be the mechanism in which contractile dysfunction is established in donors. On the other hand, hypothyroidism has been evoked as a major cause of cardiovascular disorders in brain dead subjects. It is not known whether any relationship exists between hypothyroidism and myocardial damage that appear in brain death. In this study myocardial damage and thyroid status are quantified in a donor population, and whether a correlation between hypothyroidism and myocardial damage exists is analyzed.
  
  
  METHODS
  Serum samples from 45 cardiac donors were examined for cardiac troponins T and I as myocardial damage markers, as well as thyroid hormones. Correlations between cardiac troponins and thyroid hormones were assessed.
  
  
  RESULTS
  One or both cardiac troponins were elevated in 19 donors (42.2%). Hypothyroidism was a very frequent finding, since it was present in 39 donors (86.7%). No correlation was observed between any of the myocardial damage markers and thriiodothyronine levels.
  
  
  CONCLUSIONS
  Hypothyroidism and myocardial damage are common in brain dead donors. No association exists between both disorders.
authors: Servicios de Cardiología ospital San Sebastián, Ecija, Hospital Universitario Virgen del Rocío, Sevilla. lhaldon@interbook.net
authors: J
authors: J
authors: López Haldón
authors: Martínez Martínez A
authors: A
authors: A
authors: Ordóñez
authors: J
authors: J
authors: Marqués
authors: J
authors: J
authors: Miguel Borrego
authors: J
authors: J
authors: Luis Serrera
mesh_terms: D000293:Adolescent; D000328:Adult; D001926:Brain Death / Q000097:blood; D002648:Child; D005260:Female; D006331:Heart Diseases / Q000097:blood / Q000209:etiology*; D016027:Heart Transplantation; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D014019:Tissue Donors; D019210:Troponin I / Q000097:blood; D020107:Troponin T / Q000097:blood
chemical_list: D019210:Troponin I; D020107:Troponin T