Acute effect of hemodialysis with polyacrylonitrile membrane on nerve conduction velocities.
OBJECTIVE
Non cellulosic membranes, as polyacrylonitrile (AN69) improves middle-molecules purification through hemodialysis, and this increased clearance of middle-molecules may have benefical effects on uremic polyneuropathy. We have tried to evaluate this effect comparing nerve conduction velocities before and after hemodialysis with either AN69 or cellulose acetate (CA).


METHODS
Eight patients in hemodialysis with AN69 for more than three months (4 men and 4 women, mean age 58.4 +/- 12.9 years, mean time in hemodialysis 9.3 +/- 7.5 months). Motor conduction velocities (MCV) and sensory conduction velocities (SCV) were measured predialysis and postdialysis with AN69 and, one week later, predialysis and postdialysis with CA.


RESULTS
There were no differences neither in Kt/V values (AN69 1.27 +/- 0.36 vs CA 1.16 +/- 0.26) nor in TAC ones (AN69 40.8 +/- 17.4 vs CA 40.8 +/- 21.3 mg/dL). After hemodialysis with AN69 MCV significantly increased (42.0 +/- 3.0 vs 40.6 +/- 2.6 m/s baseline, p < 0.05). SCV was also enhanced (45.3 +/- 2.2 vs 41.1 +/- 3.4 m/s baseline, p < 0.05). After hemodialysis with CA neither MCV changed (42.7 +/- 1.6 vs 42.0 +/- 2.3 m/s baseline), nor did SCV (45.8 +/- 5.8 vs 44.8 +/- 3.0 m/s baseline).


CONCLUSIONS
Hemodialysis with AN69 acutely improved SCV and MCV. This effect was not seen with CA hemodialysis.
Robles
N R
NR
Sección de Nefrologia, Hospital Infanta Cristina, Badajoz, Spain. nroblesp@meditex.es
Cancho
B
B
Pizarro
J
J
Solis
M
M
Alvarez Mato
C
C
Sánchez-Casado
E
E
D000180:Acrylic Resins; D005260:Female; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D009431:Neural Conduction / Q000502:physiology*; D006435:Renal Dialysis
D000180:Acrylic Resins; D008567:Membranes, Artificial; C010504:polyacrylonitrile