Acetaminophen poisoning and the use of intravenous N-acetylcysteine.
Acetaminophen (N-acetyl-p-aminophenol) is the most widely used antipyretic and analgesic in the United States. Acetaminophen, a combination agent in approximately 125 medications, has been deemed safe and effective when used within the recommended dosage. In 1998 and 1999, however, 203,930 cases of acetaminophen overingestion were reported to U.S. poison centers, making it the leading pharmacologic agent associated with toxicity.
Clark
J
J
Life Lion Air Medical Service, Penn State Milton S. Hershey Medical Center, Hershey, Pa., USA.
D000082:Acetaminophen / Q000008:administration & dosage / Q000506:poisoning*; D000111:Acetylcysteine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002648:Child; D062787:Drug Overdose; D004638:Emergency Treatment / Q000379:methods / Q000592:standards*; D006801:Humans; D007262:Infusions, Intravenous; D017114:Liver Failure, Acute / Q000139:chemically induced / Q000517:prevention & control
D000082:Acetaminophen; D000111:Acetylcysteine