title: Anti-plaque efficacy of a chalk-based antimicrobial dentifrice.
abstract: A chalk-based antimicrobial dentifrice was developed and has undergone in vitro testing to determine antimicrobial efficacy by kill-time studies, and in vivo clinical studies to determine anti-plaque build-up properties. The antimicrobial efficacy of the formulation is attributable to the following components; sodium lauryl sulphate, sodium monofluorophosphate, flavouring oils, triclosan, and low water activity. In vitro kill-time testing showed the dentifrice to have good activity against organisms associated with plaque, showing at least 99% reductions in the numbers of each organism. In vivo clinical results showed the dentifrice to protect against the build-up of plaque when compared to water alone. These results demonstrate that this dentifrice is effective in controlling plaque, and can thus be expected to promote good oral hygiene.
authors: GlaxoSmithKline Consumer Healthcare, St. George's Avenue, Weybridge, Surrey, KT13 ODE, United Kingdom. robert.d.lewis@sb.com
authors: R D
authors: RD
authors: Lewis
authors: B F
authors: BF
authors: Marken
authors: S R
authors: SR
authors: Smith
mesh_terms: D000704:Analysis of Variance; D000891:Anti-Infective Agents, Local / Q000494:pharmacology / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects; D002119:Calcium Carbonate / Q000494:pharmacology / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D003802:Dentifrices / Q000737:chemistry* / Q000494:pharmacology / Q000627:therapeutic use*; D005459:Fluorides / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests; D010710:Phosphates / Q000494:pharmacology / Q000627:therapeutic use; D016037:Single-Blind Method; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology / Q000627:therapeutic use; D013501:Surface-Active Agents / Q000494:pharmacology / Q000627:therapeutic use; D014260:Triclosan / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000891:Anti-Infective Agents, Local; D003802:Dentifrices; D010710:Phosphates; D013501:Surface-Active Agents; C012980:fluorophosphate; D012967:Sodium Dodecyl Sulfate; D014260:Triclosan; D002119:Calcium Carbonate; D005459:Fluorides