How to predict proliferative vitreoretinopathy: a prospective study.
OBJECTIVE
To determine prospectively the accuracy of a predictive risk formula for the development of postoperative proliferative vitreoretinopathy (PVR) when applied in a clinical setting.


METHODS
Prospective noncomparative interventional case series.


METHODS
Two hundred nineteen subjects undergoing primary vitrectomy for rhegmatogenous retinal detachment were studied.


METHODS
By use of a formula-based discriminant rule, subjects were classified as either high or low risk for the development of PVR. All subjects were followed prospectively.


METHODS
Development of postoperative PVR as defined by the updated the Retina Society Classification.


RESULTS
Complete data were available on 212 of 219 subjects. There were 130 subjects identified as low risk and 82 subjects as high risk; 9.2% of the low-risk (12 of 130) compared with 28% (23 of 82) of the high-risk subjects had postoperative PVR develop. This difference was statistically significant (P < 0.001).


CONCLUSIONS
Our study has shown that using a clinical model it is possible to identify subjects at greater risk of PVR developing after primary vitrectomy.
Asaria
R H
RH
Departments of Vitreoretinal Surgery and Glaucoma, Moorfields Eye Hospital, London, England, UK.
Kon
C H
CH
Bunce
C
C
Charteris
D G
DG
Wong
D
D
Luthert
P J
PJ
Khaw
P T
PT
Aylward
G W
GW
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003941:Diagnostic Techniques, Ophthalmological; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D015203:Reproducibility of Results; D012163:Retinal Detachment / Q000601:surgery; D012307:Risk Factors; D014821:Vitrectomy / Q000009:adverse effects; D018630:Vitreoretinopathy, Proliferative / Q000175:diagnosis* / Q000209:etiology