title: Application of a gamma model of absorption to oral cyclosporin.
abstract: BACKGROUND
  Some drugs, such as cyclosporin, exhibit flat and delayed absorption profiles, with a correlation between the delay and the peak width. Such profiles can be described by an absorption model in which the absorption rate is derived from a gamma distribution (of which the classical first-order absorption model is a special case).
  
  
  OBJECTIVE
  To develop a model for the pharmacokinetics of extravascular administration of cyclosporin and apply it to a study of the pharmacokinetics of cyclosporin microemulsion in stable renal transplant recipients.
  
  
  METHODS
  21 renal transplant patients receiving oral cyclosporin microemulsion 75 to 175 mg twice daily.
  
  
  METHODS
  The equation of the plasma concentration-time curve after oral administration was expressed as a convolution product between the absorption rate and a multi-exponential impulse response. The convolution integral was computed analytically and expressed in terms of the incomplete gamma function. Cyclosporin was assayed by liquid chromatography/mass spectrophotometry. The model was fitted by nonlinear regression, using a specially developed program.
  
  
  RESULTS
  The gamma model yielded a good fit in all of the 21 patients studied. Attempts to fit the same data by a classical exponential with lag-time model failed in most patients.
  
  
  CONCLUSIONS
  This model could simplify the Bayesian monitoring of cyclosporin therapy.
authors: Service de Pharmacologie-Toxicologie, Hĵpital Dupuytren, Limoges, France. debord@unilim.fr
authors: J
authors: J
authors: Debord
authors: E
authors: E
authors: Risco
authors: M
authors: M
authors: Harel
authors: Y
authors: Y
authors: Le Meur
authors: M
authors: M
authors: Büchler
authors: G
authors: G
authors: Lachâtre
authors: C
authors: C
authors: Le Guellec
authors: P
authors: P
authors: Marquet
mesh_terms: D019540:Area Under Curve; D001499:Bayes Theorem; D001682:Biological Availability; D016572:Cyclosporine / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007408:Intestinal Absorption; D016030:Kidney Transplantation; D008954:Models, Biological
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine