Anti-inflammatory and spasmolytic activity of extracts from Droserae herba.
An ethanolic extract of Drosera madagascariensis inhibited human neutrophil elastase with an IC50 of 9.4 microg/ml. The naphthoquinones present in the extract were not responsible for this effect, but flavonoids like quercetin (IC50 0.8 microg/ml), hyperoside (IC50 0.15 microg/ml) and isoquercitrin (IC50 0.7 microg/ml) contributed to inhibition of the enzyme. In guinea-pig ileum the extract (0.5-1 mg/ml) induced a spasmolytic effect via affecting cholinergic M3 receptors and histamine H1 receptors, respectively. At contractile prostanoid receptors of guinea-pig trachea the Drosera extract was not effective.
Melzig
M F
MF
Institut für Pharmazie, Humboldt-Universität zu Berlin, Germany. matthias.f.melzig@rz.hu-berlin.de
Pertz
H H
HH
Krenn
L
L
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D029787:Drosera / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects / Q000378:metabolism; D019272:Leukocyte Elastase / Q000097:blood; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism; D010276:Parasympatholytics / Q000494:pharmacology*; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D011794:Quercetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism; D011969:Receptors, Histamine H1 / Q000187:drug effects / Q000378:metabolism; D011982:Receptors, Prostaglandin / Q000187:drug effects / Q000378:metabolism; D014132:Trachea / Q000187:drug effects / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D004791:Enzyme Inhibitors; D010276:Parasympatholytics; D010936:Plant Extracts; D011950:Receptors, Cholinergic; D011969:Receptors, Histamine H1; D011982:Receptors, Prostaglandin; C016527:isoquercitrin; C021304:hyperoside; D011794:Quercetin; D019272:Leukocyte Elastase