title: The indication of local excision for T2 rectal carcinomas.
abstract: BACKGROUND
  Several researchers reported that local excision with or without postoperative chemo-radiation therapy is an alternative approach for sphincter preservation in patients with locally invasive rectal carcinoma. However, indications and long-term results have not yet been determined.
  
  
  METHODS
  Seventy-two patients with T2 colorectal carcinomas underwent bowel resection with regional lymph node dissection. The associations between lymph node metastasis (LNM) and clinicopathologic factors were examined with special reference to the presence or absence of moderate to severe degree of focal dedifferentiation or mucinous component at the invasive margin (unfavorable histology).
  
  
  RESULTS
  Multivariate logistic regression analysis revealed that both sex and unfavorable histology were significantly associated with LNM (P = 0.0102, 0.0226, respectively). However, the associations between LNM and lymphatic invasion or tumor location were not statistically significant (P = 0.0947, 0.1738).
  
  
  CONCLUSIONS
  When locally resected T2 rectal carcinoma specimens have unfavorable histology at the invasive margin, additional bowel resection with lymph node dissection should be recommended.
authors: First Department of Surgery, Kyorin University, Mitaka City, Tokyo, Japan. masaki@kyorin-u.ac.jp
authors: T
authors: T
authors: Masaki
authors: M
authors: M
authors: Sugiyama
authors: Y
authors: Y
authors: Atomi
authors: H
authors: H
authors: Matsuoka
authors: N
authors: N
authors: Abe
authors: T
authors: T
authors: Watanabe
authors: H
authors: H
authors: Nagawa
authors: T
authors: T
authors: Muto
mesh_terms: D015179:Colorectal Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D012004:Rectal Neoplasms / Q000401:mortality / Q000601:surgery*; D012007:Rectum / Q000473:pathology / Q000601:surgery; D015996:Survival Rate