Extracellular matrix remodeling in the vascular wall.
The extracellular matrix provides a structural framework essential for the functional properties of vessel walls. The three dimensional organization of the extracellular matrix molecules--elastin, collagens, proteoglycans and structural glycoproteins--synthesized during fetal development--is optimal for these functions. Early in life, the vessel wall is subjected to injury: lipid deposition, hypoxia, enzyme secretion and reactive oxygen species production during inflammatory processes, and the extracellular matrix molecules are hydrolyzed by proteases--matrix metalloproteinases, leukocyte elastase, etc. In uninjured arteries and veins, some proteases are constitutively expressed, but through the control of their activation and/or their inhibition by inhibitors, these proteases have a very low activity. During the occurrence of vascular pathologies--atherosclerosis, hypertension, varicosis, restenosis, etc.--the balance between proteases and their inhibitors is temporally destroyed through the induction of matrix metalloproteinase gene expression or the secretion of enzymes by inflammatory cells. Smooth muscle cells, the most numerous cells in vascular walls, have a high ability to respond to injury through their ability to synthesize extracellular matrix molecules and protease inhibitors. However, the three dimensional organization of the newly synthesized extracellular matrix is never functionally optimal. In some other pathologies--aneurysm--the injury overcomes the responsive capacity of smooth muscle cells and the quantity of extracellular matrix decreases. In conclusion, care should be taken to maintain the vascular extracellular matrix reserve and any therapeutic manipulation of the protease/inhibitor balance must be perfectly controlled, because an accumulation of abnormal extracellular matrix may have unforeseen adverse effects.
Jacob
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MP
INSERM U 460, UFR de médecine Xavier Bichat, 16, rue Henri Huchard 75870 Paris, France. jacob@bichat.inserm.fr
Badier-Commander
C
C
Fontaine
V
V
Benazzoug
Y
Y
Feldman
L
L
Michel
J B
JB
D000783:Aneurysm / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001808:Blood Vessels / Q000737:chemistry / Q000648:ultrastructure*; D003094:Collagen / Q000737:chemistry / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism / Q000473:pathology; D004549:Elastin / Q000737:chemistry / Q000378:metabolism; D005109:Extracellular Matrix / Q000737:chemistry* / Q000502:physiology*; D016326:Extracellular Matrix Proteins / Q000737:chemistry / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000378:metabolism / Q000473:pathology; D014648:Varicose Veins / Q000378:metabolism / Q000473:pathology
D016326:Extracellular Matrix Proteins; D003094:Collagen; D004549:Elastin