title: Cloning of a catalytic subunit of cAMP-dependent protein kinase from the honeybee (Apis mellifera) and its localization in the brain.
abstract: In the honeybee the cAMP-dependent signal transduction cascade has been implicated in processes underlying learning and memory. The cAMP-dependent protein kinase (PKA) is the major mediator of cAMP action. To characterize the PKA system in the honeybee brain we cloned a homologue of a PKA catalytic subunit from the honeybee. The deduced amino acid sequence shows 80-94% identity with catalytic subunits of PKA from Drosophila melanogaster, Aplysia californica and mammals. The corresponding gene is predominantly expressed in the mushroom bodies, a structure that is involved in learning and memory processes. However, expression can also be found in the antennal and optic lobes. The level of expression varies within all three neuropiles.
authors: Freie Universitaet Berlin, Institut für Biologie-Neurobiologie, Koenigin-Luise-Strasse 28/30, 14195 Berlin, Germany. theodora@zedat.fu-berlin.de
authors: D
authors: D
authors: Eisenhardt
authors: A
authors: A
authors: Fiala
authors: P
authors: P
authors: Braun
authors: H
authors: H
authors: Rosenboom
authors: H
authors: H
authors: Kress
authors: P R
authors: PR
authors: Ebert
authors: R
authors: R
authors: Menzel
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001516:Bees / Q000201:enzymology* / Q000235:genetics; D001921:Brain / Q000201:enzymology*; D020134:Catalytic Domain; D003001:Cloning, Molecular; D017868:Cyclic AMP-Dependent Protein Kinases / Q000235:genetics* / Q000378:metabolism; D018076:DNA, Complementary; D008969:Molecular Sequence Data; D020539:Sequence Analysis, Protein; D017386:Sequence Homology, Amino Acid
chemical_list: D018076:DNA, Complementary; D017868:Cyclic AMP-Dependent Protein Kinases