Proton magnetic resonance spectroscopy of choroid plexus tumors in children.
A variety of lesions may present as intraventricular masses in children. We report quantitative proton magnetic resonance spectroscopy (MRS) of two intraventricular tumors of the choroid plexus: choroid plexus carcinoma (CPC) and choroid plexus papilloma (CPP). Both lesions were characterized by high levels of choline-containing compounds and a complete absence of creatine and the neuronal/axonal marker N-acetyl aspartate. The CPC showed higher levels of choline compared to the CPP, and it also had elevated lactate. These preliminary results, if confirmed in a larger cohort of patients, indicate that proton MRS may have a role in the presurgical diagnosis of choroid plexus tumors in children, which may also have important implications for therapy and prognosis.
Horská
A
A
Department of Radiology, Johns Hopkins University, Baltimore, Maryland 21205, USA. ahorska@mri.jhu.edu
Ulug
A M
AM
Melhem
E R
ER
Filippi
C G
CG
Burger
P C
PC
Edgar
M A
MA
Souweidane
M M
MM
Carson
B S
BS
Barker
P B
PB
D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001929:Brain Edema / Q000175:diagnosis; D002675:Child, Preschool; D002794:Choline / Q000032:analysis; D002831:Choroid Plexus / Q000473:pathology; D016545:Choroid Plexus Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004292:Dominance, Cerebral / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D020288:Papilloma, Choroid Plexus / Q000175:diagnosis*; D019047:Phantoms, Imaging; D011237:Predictive Value of Tests
D001224:Aspartic Acid; C000179:N-acetylaspartate; D002794:Choline