title: Abnormal uterus with polycysts, accumulation of uterine prostaglandins, and reduced fertility in mice heterozygous for acyl-CoA synthetase 4 deficiency.
abstract: Arachidonate released by various stimuli is rapidly reesterified into membrane phospholipids initiated by acyl-CoA synthetase (ACS) and subsequent acyl-transfer reactions. ACS4 is an arachidonate-preferring enzyme abundant in steroidogenic tissues and postulated to modulate eicosanoid production. Female mice heterozygous for ACS4 deficiency become pregnant less frequently and produce small litters with extremely low transmission of the disrupted alleles. Striking morphological changes, including extremely enlarged uteri and lumina filled with numerous proliferative cysts of various sizes, were detected in ACS4+/- females. Furthermore, marked accumulation of prostaglandins was seen in the uterus of the heterozygous females. These results indicate that ACS4 modulates female fertility and uterine prostaglandin production.
authors: Tohoku University Gene Research Center, Sendai, 981-8555, Japan.
authors: Y Y
authors: YY
authors: Cho
authors: M J
authors: MJ
authors: Kang
authors: H
authors: H
authors: Sone
authors: T
authors: T
authors: Suzuki
authors: M
authors: M
authors: Abe
authors: M
authors: M
authors: Igarashi
authors: T
authors: T
authors: Tokunaga
authors: S
authors: S
authors: Ogawa
authors: Y A
authors: YA
authors: Takei
authors: T
authors: T
authors: Miyazawa
authors: H
authors: H
authors: Sasano
authors: T
authors: T
authors: Fujino
authors: T T
authors: TT
authors: Yamamoto
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D002678:Chimera; D003066:Coenzyme A Ligases / Q000172:deficiency* / Q000235:genetics; D003433:Crosses, Genetic; D003560:Cysts / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology; D015237:Dinoprost / Q000378:metabolism; D015232:Dinoprostone / Q000378:metabolism; D005260:Female; D005838:Genotype; D006579:Heterozygote; D007247:Infertility, Female / Q000201:enzymology / Q000235:genetics*; D008098:Litter Size; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D011453:Prostaglandins / Q000378:metabolism*; D015183:Restriction Mapping; D012744:Sex Ratio; D014591:Uterine Diseases / Q000201:enzymology / Q000235:genetics* / Q000503:physiopathology; D014599:Uterus / Q000378:metabolism*
chemical_list: D011453:Prostaglandins; D015121:6-Ketoprostaglandin F1 alpha; D015237:Dinoprost; D003066:Coenzyme A Ligases; D015232:Dinoprostone