[Experimental study of preventive effect of xin-kang oral liquid on acute viral myocarditis in mice].
OBJECTIVE
To study the preventive effect of Xin-Kang oral liquid on acute Coxsackie B3 viral myocarditis in mice.


METHODS
The mice were infected Coxsackie virus B3 (CVB3m) through abdominal cavity after they were fed with the Xin-Kang oral liquid for 2d, and the uses of the drug continued to the 20th day. Histopathological changes of the myocardial cells were observed under microscope and measured by morphometric quantification.


RESULTS
The detection rate of pathological change of grade III of heart surface in Xin-Kang oral liquid groups were lower than in virus control group, the difference between Xin-Kang medium dose group and virus control group being specially significant (P < 0.01), and the detection rate of severe myocardial damage was much lower. The average area of myocardial damage and area of myocardial damage/area of the whole heart in Xin-Kang oral liquid groups were markedly lower than those in virus control at the 5th day and the 20th day.


CONCLUSIONS
These results demonstrate that the preventive effect of Xin-Kang oral liquid on acute Coxsackie B3 viral myocarditis is similar to that of interferon.
Zhao
H
H
Cardiovascular Institute and Fu Wai Hospital, CAMS and PUMC, Beijing 100037, China.
Wan
S
S
Xu
X
X
D000208:Acute Disease; D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D003384:Coxsackievirus Infections / Q000473:pathology / Q000517:prevention & control*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D051379:Mice; D009205:Myocarditis / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D009206:Myocardium / Q000473:pathology; D008517:Phytotherapy
D000998:Antiviral Agents; D004365:Drugs, Chinese Herbal