title: Hypnotic action of melatonin during daytime administration and its comparison with triazolam.
abstract: The present study was conducted to assess hypnotic action, effects on rectal temperature and dose dependency by daytime administration of exogenous melatonin (MLT) at 1 mg, 3 mg or 6 mg to subjects consisting of seven healthy juvenile adults. As a result, exogenous MLT significantly increased total sleep time and sleep efficiency, and MLT 6 mg was observed to demonstrate hypnotic effects that were nearly equal to those of triazolam at 0.125 mg. Rectal temperature was significantly decreased at MLT 1mg and 3 mg, there were no significant differences observed in the hypothermic effects at MLT 6 mg. These results indicate that exogenous MLT had dose-dependent hypnotic action on daytime sleep, and it is possible to consider that this hypnotic action was based on a direct-acting mechanism.
authors: Department of Neuropsychiatry,Kurume University School of Medicine, Kurume, Japan. satomura@mx2.tiki.ne.jp
authors: T
authors: T
authors: Satomura
authors: T
authors: T
authors: Sakamoto
authors: S
authors: S
authors: Shirakawa
authors: Y
authors: Y
authors: Tsutsumi
authors: M
authors: M
authors: Mukai
authors: T
authors: T
authors: Ohyama
authors: N
authors: N
authors: Uchimura
authors: H
authors: H
authors: Maeda
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects*; D018757:GABA Modulators / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000008:administration & dosage / Q000494:pharmacology*; D012007:Rectum / Q000502:physiology; D012016:Reference Values; D014229:Triazolam / Q000494:pharmacology*
chemical_list: D018757:GABA Modulators; D006993:Hypnotics and Sedatives; D014229:Triazolam; D008550:Melatonin