title: Isoindolines: a new series of potent and selective endothelin-A receptor antagonists.
abstract: 1,3-Disubstituted isoindolines have been discovered as a new class of potent functional ET(A) selective receptor antagonists through pharmacophore analysis of existing nonpeptide endothelin antagonists. The structure-activity relationships for both the trans and the cis series of isoindolines are discussed.
authors: Metabolic and Cardiovascular Diseases, Novartis Institute for Biomedical Research, 07901, Summit NJ, USA. paivi.kukkola@pharma.novartis.com
authors: P J
authors: PJ
authors: Kukkola
authors: N A
authors: NA
authors: Bilci
authors: T
authors: T
authors: Ikler
authors: P
authors: P
authors: Savage
authors: S S
authors: SS
authors: Shetty
authors: D
authors: D
authors: DelGrande
authors: A Y
authors: AY
authors: Jeng
mesh_terms: D065128:Endothelin Receptor Antagonists; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin / Q000737:chemistry
chemical_list: D065128:Endothelin Receptor Antagonists; D007211:Indoles; D044022:Receptor, Endothelin A; D017466:Receptors, Endothelin