title: Mutualists and parasites: how to paint yourself into a (metabolic) corner.
abstract: Eukaryotes have developed an elaborate series of interactions with bacteria that enter their bodies and/or cells. Genome evolution of symbiotic and parasitic bacteria multiplying inside eukaryotic cells results in both convergent and divergent changes. The genome sequences of the symbiotic bacteria of aphids, Buchnera aphidicola, and the parasitic bacteria of body louse and humans, Rickettsia prowazekii, provide insights into these processes. Convergent genome characteristics include reduction in genome sizes and lowered G+C content values. Divergent evolution was recorded for amino acid and cell wall biosynthetic genes. The presence of pseudogenes in both genomes provides examples of recent gene inactivation events and offers clues to the process of genome deterioration and host-cell adaptation.
authors: Department of Molecular Evolution, University of Uppsala, Norbyvägen 18C, S-752 36, Uppsala, Sweden.
authors: I
authors: I
authors: Tamas
authors: L M
authors: LM
authors: Klasson
authors: J P
authors: JP
authors: Sandström
authors: S G
authors: SG
authors: Andersson
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001042:Aphids / Q000382:microbiology*; D020635:Buchnera / Q000235:genetics* / Q000502:physiology; D004734:Energy Metabolism; D019143:Evolution, Molecular; D016680:Genome, Bacterial; D006801:Humans; D010374:Pediculus / Q000382:microbiology*; D012283:Rickettsia prowazekii / Q000235:genetics* / Q000502:physiology; D013559:Symbiosis