Chromosomal instability detected by fluorescence in situ hybridization in Japanese breast cancer patients.
The relationship between chromosomal instability (CIN) and prognostic factors was investigated in 31 breast cancers and 5 benign breast lesions (three fibroadenomas and two papillomas). Using fluorescence in situ hybridization (FISH) with chromosome-specific DNA probes of chromosomes 1, 2, 6, 7, 10, 11, 17 and 18, CIN for each case was determined. CIN varied from 8.1% to 59.3% among the breast cancer patients tested, and was significantly higher than that observed in the benign breast lesions (p<0.01). Moreover, CIN showed a significant correlation with lymph node metastases (p<0.05) and estrogen receptor negativity (p<0.01). These findings suggest that CIN might be useful in the prediction of the biological aggressiveness of breast cancers.
Takami
S
S
Gene-Diagnostic Center, Otsuka Assay Laboratories, Otsuka Pharmaceutical Co., Ltd., 224-18 Aza Ebisuno Hiraishi, Kawauchi-cho, Tokushima, Japan.
Kawasome
C
C
Kinoshita
M
M
Koyama
H
H
Noguchi
S
S
D044466:Asian People / Q000235:genetics; D001943:Breast Neoplasms / Q000235:genetics* / Q000473:pathology; D002277:Carcinoma / Q000235:genetics / Q000473:pathology / Q000556:secondary; D002869:Chromosome Aberrations / Q000235:genetics* / Q000473:pathology; D025063:Chromosome Disorders; D005260:Female; D018226:Fibroadenoma / Q000235:genetics / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007564:Japan; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D010212:Papilloma / Q000235:genetics / Q000473:pathology; D011960:Receptors, Estrogen / Q000378:metabolism
D011960:Receptors, Estrogen