title: Reactive ketenes through a carbonate/amine shuttle deprotonation strategy: catalytic, enantioselective alpha-bromination of acid chlorides.
abstract: [reaction: see text] We have developed an efficient methodology for the generation of ketenes by employing a catalytic shuttle base and potassium carbonate as a stoichiometric base. We have applied this technology to the catalytic, asymmetric alpha-bromination of acid chlorides.
authors: Department of Chemistry, Johns Hopkins University, 3400 North Charles St., Baltimore, Maryland 21218, USA.
authors: A M
authors: AM
authors: Hafez
authors: A E
authors: AE
authors: Taggi
authors: H
authors: H
authors: Wack
authors: J
authors: J
authors: Esterbrook
authors: T
authors: T
authors: Lectka