[Equine estrogens vs. esterified estrogens in the climacteric and menopause. The controversy arrives in Mexico].
It exists controversies about if the effects and benefits of the esterified estrogens could be similar to those informed for equines, because its chemical composition and bioavailability are different. Esterified estrogens has not delta 8,9 dehydroestrone, and its absorption and level of maximum plasmatic concentrations are reached very fast. In United States of America and another countries, esterified estrogens has been marketed and using for treatment of climacteric syndrome and prevention of postmenopausal osteoporosis, based on the pharmacopoiea of that country, but the Food and Drug administration (FDA) has not yet authorized up today, a generic version of conjugated estrogens. In Instituto Mexicano del Seguro Social (IMSS) and another institutions of health sector in Mexico, starting in year 2000, it has been used esterified estrogens for medical treatment of climacteric and menopausal conditions. For this reason, in this paper we revised the most recent information about pharmacology, chemical composition, clinical use and costs of the conjugated estrogens with the purpose to guide the decisions to purchase this kind of drugs in Mexican heath institutions.
Velasco-Murillo
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División de Salud Materna, Coordinación de Salud Reproductiva y Materno Infantil, Mier y Pesado 120 Colonia del Valle, Delegación Benito Juarez, C.P. 03100, México, Distrito Federal. Viteliov@aol.com viteliov@yahoo.es
D000368:Aged; D000818:Animals; D002979:Climacteric; D003362:Cost-Benefit Analysis; D016527:Drug Costs; D004951:Esterification; D015914:Estrogen Replacement Therapy / Q000191:economics / Q000379:methods*; D004967:Estrogens / Q000737:chemistry / Q000191:economics / Q000302:isolation & purification / Q000627:therapeutic use*; D004966:Estrogens, Conjugated (USP) / Q000737:chemistry / Q000191:economics / Q000302:isolation & purification / Q000627:therapeutic use*; D005260:Female; D006736:Horses; D006801:Humans; D008593:Menopause; D008800:Mexico; D008875:Middle Aged; D009313:National Health Programs; D010944:Plants / Q000737:chemistry; D011247:Pregnancy; D014481:United States; D014486:United States Food and Drug Administration; D014556:Urine / Q000737:chemistry
D004967:Estrogens; D004966:Estrogens, Conjugated (USP)