Acquired immunodeficiency syndrome-related cancer. A study model for the mechanisms contributing to the genesis of cancer.
The study of AIDS and cancer has resulted in an important convergence of clinical-epidemiological investigations, molecular research and virological studies. This shared effort has led to significant discoveries in the field of human carcinogenesis. In a relatively short time, several topics have been clarified, namely: (1) the spectrum of AIDS-related tumours has been identified; (2) the role of HIV in lymphomagenesis and in the development of Kaposi's sarcoma (KS) has been defined; (3) AIDS-related cancers have allowed the discovery and extensive biological characterisation of the novel virus human herpes virus 8 (HHV8), also called KS-associated herpesvirus; and (4) genetic, molecular, and phenotypic studies of AIDS-related lymphomas have contributed to the formulation of a pathogenetic and histogenetic model of B-cell non-Hodgkin's lymphomas (NHL).
Carbone
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Division of Pathology and Scientific Direction, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Via Pedemontana Occidentale, I-33081, Aviano, Italy. acarbone@cro.it
Gaidano
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G
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D019288:Herpesvirus 8, Human; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000821:virology*; D016393:Lymphoma, B-Cell / Q000821:virology; D012514:Sarcoma, Kaposi / Q000821:virology*