title: Synthesis of imidazo[4,5-d]oxazolo[3,4-a]pyridines. New heterocyclic analogues of lignans.
abstract: The preparation of new analogues of lignans carrying an imidazole ring has been achieved. Starting from L-histidinol, cis and trans stereoisomers have been obtained. The synthesized products lack the cytotoxicity displayed by related podophyllotoxins and azatoxin.
authors: Lab. de Química Orgánica y Farmacéutica, Fac. Farmacia, Av. Campo Charro s/n, 37007 Salamanca, Spain.
authors: B
authors: B
authors: Madrigal
authors: P
authors: P
authors: Puebla
authors: E
authors: E
authors: Caballero
authors: R
authors: R
authors: Peláez
authors: D G
authors: DG
authors: Grávalos
authors: M
authors: M
authors: Medarde
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D017705:Lignans / Q000138:chemical synthesis / Q000494:pharmacology*; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D006571:Heterocyclic Compounds; D017705:Lignans; D011725:Pyridines