Timing and magnitude of frontal activity differentiates refixation and anti-saccade performance.
EEG data were recorded while 10 subjects generated refixation saccades towards a visual target and antisaccades away from a visual cue. Theoretically, the same basic neural circuitry supports refixation and correct anti-saccade performances, with additional activity in primarily dorsolateral prefrontal cortex circuitry supporting antisaccade-associated inhibitory processes. Analyses demonstrated that sensory registration of visual stimuli is similar for refixation and anti-saccade conditions. Increased frontal brain activity at 5 and 15 Hz was observed preceding correct antisaccades when compared to refixation saccades. These analyses provide specific information suggesting that 160-60 ms before saccade generation is the critical period for response inhibition.
Clementz
B A
BA
Department of Psychology, University of California, 9500 Gilman Drive, La Jolla, CA 92093-0109, USA.
McDowell
J E
JE
Stewart
S E
SE
D000328:Adult; D001931:Brain Mapping; D004569:Electroencephalography; D005260:Female; D005583:Fourier Analysis; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008297:Male; D009415:Nerve Net / Q000033:anatomy & histology / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology*; D009483:Neuropsychological Tests; D009949:Orientation / Q000502:physiology; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D012438:Saccades / Q000502:physiology*; D013028:Space Perception / Q000502:physiology; D013997:Time Factors