Photodynamic therapy of actinic keratoses with topical aminolevulinic acid hydrochloride and fluorescent blue light.
BACKGROUND
Aminolevulinic acid hydrochloride (ALA, Levulan) applied topically to actinic keratoses (AKs) leads to accumulation of the photosensitizer protoporphyrin IX, which, when activated by exposure to light, eradicates AKs.


OBJECTIVE
We examined the safety and efficacy of photodynamic therapy using topical 20% ALA in a solution formulation and varying blue light doses to treat multiple AKs on the face and scalp.


METHODS
This is a multicenter, investigator-blinded, randomized, vehicle-controlled study.


RESULTS
Thirty-six patients with clinically typical AKs were treated with 20% ALA; 14 to 18 hours later, they were irradiated with a nonlaser fluorescent blue light source. With the optimal light dose of 10 J/cm(2), 88% of the AKs completely cleared 8 weeks after a single photodynamic treatment, compared with 6% after treatment with vehicle and light.


CONCLUSIONS
Topical ALA PDT using a nonlaser, blue light source is an effective treatment for multiple AKs.
Jeffes
E W
EW
Department of Dermatology, University of California, Irvine 92697, USA.
McCullough
J L
JL
Weinstein
G D
GD
Kaplan
R
R
Glazer
S D
SD
Taylor
J R
JR
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000622:Aminolevulinic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007642:Keratosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D016037:Single-Blind Method; D016896:Treatment Outcome
D000622:Aminolevulinic Acid