title: The in vivo activity of olamufloxacin (HSR-903) in systemic and urinary tract infections in mice.
abstract: The in vivo activity of olamufloxacin (HSR-903), a new fluoroquinolone, was evaluated and compared with ciprofloxacin, sparfloxacin and levofloxacin. Olamufloxacin was active against systemic infection in mice inoculated with both Gram-positive and -negative bacteria. Olamufloxacin had equal efficacy for experimental urinary tract infections in mice caused by Pseudomonas aeruginosa.
authors: Department of Microbiology, Toho University School of Medicine, Tokyo. Research Department, Research & Development Division, Hokuriku Seiyaku Co., Ltd, Fukui, Japan. satoshi.yoshizumi@hokuriku-seiyaku.co.jp
authors: S
authors: S
authors: Yoshizumi
authors: Y
authors: Y
authors: Takahashi
authors: M
authors: M
authors: Murata
authors: H
authors: H
authors: Domon
authors: N
authors: N
authors: Furuya
authors: Y
authors: Y
authors: Ishii
authors: T
authors: T
authors: Matsumoto
authors: A
authors: A
authors: Ohno
authors: K
authors: K
authors: Tateda
authors: S
authors: S
authors: Miyazaki
authors: K
authors: K
authors: Yamaguchi
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy*; D024841:Fluoroquinolones; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015363:Quinolones / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C106426:olamufloxacin