title: Fluorescence decay time distribution analysis of cyclic enkephalin analogues; influence of solvent and Leu configuration in position 5 on conformation.
abstract: Lifetime distribution analysis were performed to study the influence of Leu configuration in position 5 on changes of the peptide chain of cyclic analogues of enkephalins containing a fluorescence donor and acceptor in different solvents. The configuration change of Leu5 in all the analogues of enkephalins studied which contain donor-acceptor pairs has no apparent influence on Trp lifetime distributions. In contrast, there is a significant solvent effect on the shape of lifetime distribution.
authors: Faculty of Chemistry, University of Gdańsk, Poland.
authors: J
authors: J
authors: Malicka
authors: R
authors: R
authors: Ganzynkowicz
authors: M
authors: M
authors: Groth
authors: C
authors: C
authors: Czaplewski
authors: J
authors: J
authors: Karolczak
authors: A
authors: A
authors: Liwo
authors: W
authors: W
authors: Wiczk
mesh_terms: D004745:Enkephalins / Q000737:chemistry*; D007930:Leucine / Q000737:chemistry*; D008956:Models, Chemical; D015233:Models, Statistical; D011487:Protein Conformation; D013050:Spectrometry, Fluorescence; D014364:Tryptophan / Q000737:chemistry
chemical_list: D004745:Enkephalins; D014364:Tryptophan; D007930:Leucine