Bid regulation of neuronal apoptosis.
Bid is a BH3 domain only pro-apoptotic member of the Bcl-2 family which interacts with Bax to regulate apoptosis. Bax-deficient embryos show decreased neuronal programmed cell death in vivo and resistance to cytosine arabinoside (AraC)-induced neuronal apoptosis in vitro. In this report, we demonstrate that Bid-deficient embryos show no neurodevelopmental abnormalities, and Bid-deficiency has no effect on the in vitro apoptotic response of either telencephalic neural precursor cells or neurons to AraC-induced death. We conclude that bid does not play an essential role in either naturally occurring or genotoxin-induced neuronal cell death.
Leonard
J R
JR
Department of Neurological Surgery, Washington University School of Medicine, 660 S. Euclid Avenue Box 8118, St. Louis, MO 63110, USA.
D'Sa
C
C
Cahn
B R
BR
Korsmeyer
S J
SJ
Roth
K A
KA
D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects / Q000502:physiology*; D051023:BH3 Interacting Domain Death Agonist Protein; D001921:Brain / Q000166:cytology / Q000196:embryology; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism*; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism; D003561:Cytarabine / Q000494:pharmacology; D005260:Female; D005727:Ganglia, Spinal / Q000166:cytology / Q000196:embryology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D020287:In Situ Nick-End Labeling; D051379:Mice; D018345:Mice, Knockout; D009153:Mutagens / Q000494:pharmacology; D009474:Neurons / Q000166:cytology*; D011247:Pregnancy; D013234:Stem Cells / Q000166:cytology
D000964:Antimetabolites, Antineoplastic; D051023:BH3 Interacting Domain Death Agonist Protein; C494815:Bid protein, mouse; D002352:Carrier Proteins; D009153:Mutagens; D003561:Cytarabine; C505409:Casp3 protein, mouse; D053148:Caspase 3; D020169:Caspases