title: [Synthesis and pharmacological study of 7-phenyl-1,4-diazepin-5-one and its derivatives].
abstract: We studied the synthesis and psychotropic activity of the 7-phenyl-1,4-diazepin-5-one and derivatives. It can be conclude that these products have sedative, myorelaxant and anxiolytic actions. The toxicity study demonstrated that two diazepines are non-toxic at therapeutic dosages but that a third compound is very toxic.
authors: Laboratoire de Chimie Organique Hétérocyclique, Faculté des Sciences, Avenue Ibn Battouta, BP 1014 Rabat (Maroc).
authors: M
authors: M
authors: Chammache
authors: A
authors: A
authors: Zellou
authors: E M
authors: EM
authors: Essassi
authors: Y
authors: Y
authors: Cherrah
authors: M
authors: M
authors: Hassar
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006573:Heterocyclic Compounds, 1-Ring / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000494:pharmacology; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats
chemical_list: C432903:7-phenyl-1,4-diazepin-5-one; D001555:Benzene Derivatives; D006573:Heterocyclic Compounds, 1-Ring; D006993:Hypnotics and Sedatives; D011619:Psychotropic Drugs