Oxidative stress and neuroAIDS: triggers, modulators and novel antioxidants.
Neurological disorders represent one of the most common disturbances accompanying HIV infection. In the past few years, highly antiretroviral active therapy has significantly reduced the incidence of HIV-related diseases. However, neurological dysfunction in AIDS patients still remains an unresolved problem. Oxidative stress, which occurs in brain tissues of patients undergoing HIV infection and is implicated in cell death of both astroglia and neurones, has recently been suggested to play a role in the pathogenesis of neuroAIDS. Thus, a better understanding of the processes that trigger and modulate free radical formation in brain tissues of AIDS patients might help in a successful therapeutic approach to the neuropathogenesis of HIV infection.
Mollace
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V
Faculty of Pharmacy, University of Catanzaro 'Magna Graecia', Roccelletta di Borgia, Catanzaro, Italy. mollace@libero.it
Nottet
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HS
Clayette
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Turco
M C
MC
Muscoli
C
C
Salvemini
D
D
Perno
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CF
D015526:AIDS Dementia Complex / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000378:metabolism*; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D001812:Blood-Brain Barrier / Q000187:drug effects / Q000502:physiology*; D002374:Catalase / Q000378:metabolism; D016923:Cell Death / Q000187:drug effects / Q000502:physiology; D005609:Free Radicals / Q000378:metabolism*; D015696:Gene Products, tat / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D015658:HIV Infections / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D006801:Humans; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009942:Organometallic Compounds / Q000494:pharmacology / Q000627:therapeutic use; D018384:Oxidative Stress / Q000187:drug effects / Q000502:physiology*; D013482:Superoxide Dismutase / Q000378:metabolism; D054322:tat Gene Products, Human Immunodeficiency Virus
D000894:Anti-Inflammatory Agents, Non-Steroidal; D000975:Antioxidants; D005609:Free Radicals; D015696:Gene Products, tat; C426066:M40401; D009942:Organometallic Compounds; D054322:tat Gene Products, Human Immunodeficiency Virus; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione