title: Identification of post-translationally modified proteins in proteome studies.
abstract: Proteome studies are powerful tools to solve many different problems in metabolism, signal transduction, drug discovery, and other areas of interest in life sciences. Up to now, high-sensitive methods for protein identification after two-dimensional gel electrophoresis using mass spectrometry are available. However, the identification of post-translational modifications after two-dimensional gel electrophoresis is still an unsolved problem. In this paper, we want to give several examples for the successful identification of post-translational modifications and point mutations.
authors: Institut für Physiologische Chemie, Ruhr-Universität Bochum, Germany. Albert.Sickmann@ruhr-uni-bochum.de
authors: A
authors: A
authors: Sickmann
authors: K
authors: K
authors: Marcus
authors: H
authors: H
authors: Schäfer
authors: E
authors: E
authors: Butt-Dörje
authors: S
authors: S
authors: Lehr
authors: A
authors: A
authors: Herkner
authors: S
authors: S
authors: Suer
authors: I
authors: I
authors: Bahr
authors: H E
authors: HE
authors: Meyer
mesh_terms: D000818:Animals; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods; D006801:Humans; D011499:Protein Processing, Post-Translational; D020543:Proteome / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D020543:Proteome