Expression of intercellular adhesion molecule 1 (ICAM-1) in Plasmodium falciparum-infected placenta.
We investigated the expression of intercellular adhesion molecule 1 (ICAM-1) in malarial placenta and related histological changes. Thirty-two malarial and 40 control term placentae were collected at Tanga, Tanzania and examined histologically and immunohistochemically. Malaria infected placentae were further divided into acute (15) and chronic (17) cases according to the presence of malarial pigment. The expression of ICAM-1 on monocyte, syncytio- and cytotrophoblasts, endothelial and stromal cells was assessed. Birthweight was lower and leukocyte counts higher in placentae with chronic infection. Many monocytes were present within the intervillous spaces, especially in placentae with chronic infection, and aggregated with parasitized erythrocytes. Some monocytes were adhesive to the surface of fibrinoid deposits. ICAM-1 expression on monocytes of malarial placentae was significantly conspicuous and correlated to the degree of intervillous leukocyte infiltration. Syncytiotrophoblasts often did not show ICAM-1, even though ICAM-1 was expressed by endothelium and weakly by cytotrophoblasts and stromal cells in both infected and control placentae. These results suggest that the expression of ICAM-1 on monocytes contributes to sequestration of infected erythrocytes within the intervillous spaces and their adhesion to fibrin masses and that ICAM-1 is unlikely to be associated with the direct adhesion of infected erythrocytes to the syncytiotrophoblasts.
Sugiyama
T
T
Liverpool School of Tropical Medicine, Pembroke Place, Liverpool L3 5QA, UK. tatsuo@med.akita-u.ac.jp
Cuevas
L E
LE
Bailey
W
W
Makunde
R
R
Kawamura
K
K
Kobayashi
M
M
Masuda
H
H
Hommel
M
M
D001724:Birth Weight; D002448:Cell Adhesion; D004727:Endothelium / Q000737:chemistry; D004912:Erythrocytes / Q000469:parasitology / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis*; D007958:Leukocyte Count; D016778:Malaria, Falciparum / Q000378:metabolism*; D009000:Monocytes / Q000737:chemistry / Q000473:pathology; D010920:Placenta / Q000737:chemistry* / Q000469:parasitology* / Q000473:pathology; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000378:metabolism*; D017154:Stromal Cells / Q000737:chemistry; D014327:Trophoblasts / Q000737:chemistry / Q000473:pathology
D018799:Intercellular Adhesion Molecule-1