title: Effects of short-term dietary administration of marginal levels of vitamin B(6)and fish oil on lipid composition and antioxidant defences in rat tissues.
abstract: Previous reports have shown that vitamin B(6)deficiency leads to peroxidative stress in rat organs. In this paper, we evaluated the effects on lipid peroxidation of short-term (six weeks) dietary administration of marginal contents of vitamin B(6). A further risk factor of susceptibility to peroxidation was the presence of fish oil with higher contents of n-3 polyunsaturated fatty acid (LCPUFA). The contemporaneous vitamin B(6)deficiency and presence of fish oil caused a C18:2 increase, a C20:4 decrease, and replacement of some n-6 LCPUFA with n-3 LCPUFA, without changes in the unsaturation index. In liver, TBARS production did not show any differences between dietary conditions, whereas the activities of glutathione-dependent enzymes were stimulated. In heart, fish oil increased lipid peroxidation, especially in the vitamin B(6)-deficient group.
authors: Dipartimento di Biochimica "G. Moruzzi", via Irnerio 48, Bologna, 40126, Italy.
authors: L
authors: L
authors: Cabrini
authors: R
authors: R
authors: Bergami
authors: M
authors: M
authors: Maranesi
authors: A
authors: A
authors: Carloni
authors: M
authors: M
authors: Marchetti
authors: B
authors: B
authors: Tolomelli
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D004032:Diet; D005227:Fatty Acids / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D005395:Fish Oils / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D050356:Lipid Metabolism; D015227:Lipid Peroxidation; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010938:Plant Oils / Q000494:pharmacology; D011736:Pyridoxine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E / Q000378:metabolism
chemical_list: D000975:Antioxidants; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D005395:Fish Oils; D010938:Plant Oils; D017392:Thiobarbituric Acid Reactive Substances; D014810:Vitamin E; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione; D011736:Pyridoxine