Detection of prostate cancer with a microbubble ultrasound contrast agent.
The diagnosis of prostate cancer is currently limited by the low sensitivity and specificity of systematic conventional grey-scale ultrasonography. We assessed contrast-enhanced colour Doppler ultrasonography by means of a microbubble ultrasound contrast agent to detect tumour vascularity and improve the diagnosis of prostate cancer. The use of a microbubble ultrasound contrast agent for transrectal colour Doppler targeted biopsy significantly improved the detection of prostate cancer compared with systematic biopsy following conventional grey-scale ultrasonography (p<0.001). Contrast-agent enhanced colour Doppler imaging may allow for limited targeted biopsies (five or less), which reduces costs and morbidity.
Frauscher
F
F
Klauser
A
A
Halpern
E J
EJ
Horninger
W
W
Bartsch
G
G
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D003287:Contrast Media; D019160:Endosonography; D006801:Humans; D007089:Image Enhancement; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides; D011237:Predictive Value of Tests; D011467:Prostate / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D011471:Prostatic Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging* / Q000473:pathology; D018615:Ultrasonography, Doppler, Color
D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508