title: Steroidal alkaloids from the leaves of Sarcococca coriacea of Nepalese origin.
abstract: Two new steroidal alkaloids, (-)-vaganine D (1) [(20S)-20-(N,N-dimethylamino)-3 beta-(senecioylamino)-5 alpha-pregn-16-en-4 beta-yl acetate], and (+)-nepapakistamine A (2) [(20S)-20-(N-methylamino)-3 beta-(tigloylamino)-5 alpha-pregn-16-en-2 beta,4 beta-diacetate], were isolated from the leaves of Sarcococca coriacea. Their structures were elucidated on the basis of their spectral properties. Compounds 1 and 2 were found to be cholinesterase inhibitors.
authors: Central Department of Chemistry, Tribhuvan University, Kirtipur, Kathmandu, Nepal.
authors: S K
authors: SK
authors: Kalauni
authors: M I
authors: MI
authors: Choudhary
authors: F
authors: F
authors: Shaheen
authors: M D
authors: MD
authors: Manandhar
authors: Atta-ur-Rahman
authors: M B
authors: MB
authors: Gewali
authors: A
authors: A
authors: Khalid
mesh_terms: D000818:Animals; D002800:Cholinesterase Inhibitors / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D004593:Electrophorus; D006736:Horses; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009390:Nepal; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D011374:Progesterone / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D002800:Cholinesterase Inhibitors; C433668:nepapakistamine A; C433667:vaganine D; D011374:Progesterone