Genetic pathways and histogenetic models of AIDS-related lymphomas.
Acquired immunodeficiency syndrome (AIDS)-related lymphomas consistently display a B-cell phenotype and are histogenetically related to germinal centre or post-germinal centre B cells in the overwhelming majority of cases. The pathogenesis of AIDS-related lymphoma is a multistep process involving factors provided by the host as well as alterations intrinsic to the tumour clone. The molecular pathways of viral infection and lesions of cancer-related genes associated with AIDS-related lymphomas vary substantially in different clinicopathological categories of the disease and highlight the marked degree of biological heterogeneity of these lymphomas.
Carbone
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Division of Pathology, Centro di Riferimento Oncologico, IRCCS, Istituto Nazionale Tumori, Via Pedemontana Occidentale, I-33081, Aviano, Italy. acarbone@cro.it
Gloghini
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Capello
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D
Gaidano
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G
D002051:Burkitt Lymphoma / Q000235:genetics; D020031:Epstein-Barr Virus Infections / Q000235:genetics; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000235:genetics*; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics; D009423:Nervous System Neoplasms / Q000276:immunology