The effect of amiloride on amphotericin B-induced hypokalaemia.
Amiloride was administered to 19 oncology patients exhibiting marked amphotericin B-induced electrolyte wasting. Mean serum potassium concentrations increased in the 5 days preceding and following administration (3.4 +/- 0.5 versus 3.9 +/- 0.8 mmol/L, P = 0.002). A trend towards decreased potassium supplementation was also observed (48.0 +/- 66.5 versus 29.4 +/- 43.2 mmol/day, P = 0.12). Amiloride is a therapeutic option to decrease potassium wasting in patients being treated with amphotericin B.
Bearden
D T
DT
Department of Pharmacy Practice, Albany College of Pharmacy, 106 New Scotland Avenue, Albany, NY 12208, USA. beardend@acp.edu
Muncey
L A
LA
D000328:Adult; D000368:Aged; D000584:Amiloride / Q000627:therapeutic use*; D000666:Amphotericin B / Q000009:adverse effects*; D000935:Antifungal Agents / Q000009:adverse effects*; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced / Q000188:drug therapy*; D008274:Magnesium / Q000097:blood; D008875:Middle Aged; D011188:Potassium / Q000008:administration & dosage
D000935:Antifungal Agents; D000584:Amiloride; D000666:Amphotericin B; D008274:Magnesium; D011188:Potassium