Role of alpha(2A)-adrenoceptors of locus coeruleus in regulation of plasma corticosterone content in male rats.
Administration of specific oligonucleotide selectively inhibiting alpha(2A)-adrenoceptor gene expression into the locus coeruleus of male rats for 3 days activated the hypothalamic-pituitary-adrenal system, which was manifested in a rise of blood plasma corticosterone content in rats with normal and hypertrophied (after castration) adrenal glands. These data indicate that alpha(2A)-adrenoceptors of the locus coeruleus are involved in the regulation of basal plasma corticosterone content.
Shishkina
T G
TG
Laboratory of Genetic Bases of Neuroendocrine Regulation, Institute of Cytology and Genetics, Siberian Division of the Russian Academy of Sciences, Novosibirsk. gtshi@bionet.nsc.ru
Sakharov
D G
DG
Dygalo
N N
NN
D000818:Animals; D003345:Corticosterone / Q000502:physiology*; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D018341:Receptors, Adrenergic, alpha-2 / Q000502:physiology*
D018341:Receptors, Adrenergic, alpha-2; D003345:Corticosterone