Elution characteristics of vancomycin, teicoplanin, gentamicin and clindamycin from calcium sulphate beads.
The in vitro release of vancomycin, teicoplanin, gentamicin and clindamycin from biodegradable calcium sulphate (CaSO(4)) carrier beads is described. All antibiotics showed prolonged release from the carrier beads, which was elevated during the first 24 h, with peak levels exceeding 2500 microg/bead. Doubling the antibiotic load of the beads revealed a more prolonged elution and a two-fold increase in antibiotic release. Local carrier-associated antibiotic treatment with CaSO(4) beads may prove to be effective in the management of chronic bone infections.
Wichelhaus
T A
TA
Institute of Medical Microbiology, University Hospital, Paul-Ehrlich-Strasse 40, 60596 Frankfurt am Main, Germany. Wichelhaus@em.uni-frankfurt.de
Dingeldein
E
E
Rauschmann
M
M
Kluge
S
S
Dieterich
R
R
Schäfer
V
V
Brade
V
V
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002133:Calcium Sulfate / Q000008:administration & dosage*; D002981:Clindamycin / Q000008:administration & dosage* / Q000737:chemistry; D005839:Gentamicins / Q000008:administration & dosage* / Q000737:chemistry; D014677:Pharmaceutical Vehicles; D012995:Solubility; D017334:Teicoplanin / Q000008:administration & dosage* / Q000737:chemistry; D014640:Vancomycin / Q000008:administration & dosage* / Q000737:chemistry
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014677:Pharmaceutical Vehicles; D002981:Clindamycin; D017334:Teicoplanin; D014640:Vancomycin; D002133:Calcium Sulfate