Acidic fibroblast growth factor is expressed sequentially in the progression from Barrett's esophagus to esophageal adenocarcinoma.
Acidic fibroblast growth factor 1 (FGF-1) is sequentially accumulated in Barrett's esophagus and its expression in glandular dysplasias is independent of esophageal adenocarcinoma. This suggests that FGF-1 immunohistochemistry could be used as an adjunct to the routine histopathologic diagnosis of dysplasia in Barrett's esophagus. The data also underscore the important role of fibroblast growth factors in tumorigenesis.
Soslow
R A
RA
Department of Pathology, New York Presbyterian Hospital-Weill Medical College of Cornell University (NYPH-WMC), New York, NY 10021, USA. nkaltork@mail.med.cornell.edu
Petersen
C G
CG
Remotti
H
H
Altorki
N
N
D000230:Adenocarcinoma / Q000378:metabolism* / Q000473:pathology*; D001471:Barrett Esophagus / Q000378:metabolism* / Q000473:pathology*; D001706:Biopsy; D018450:Disease Progression; D004938:Esophageal Neoplasms / Q000378:metabolism* / Q000473:pathology*; D004947:Esophagus / Q000378:metabolism* / Q000473:pathology*; D016220:Fibroblast Growth Factor 1 / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques
D016220:Fibroblast Growth Factor 1