title: Churg-Strauss syndrome.
abstract: OBJECTIVE
  This article discusses the clinical manifestations and treatment protocols of Churg-Strauss syndrome (CSS). A review of the definition, pathophysiology, and prognosis of CSS is included, as well as more recent evidence of the presumed association between antileukotriene antagonists and CSS.
  
  
  METHODS
  Relevant articles in the medical literature derived from searching the MEDLINE database (1966 to present) with key terms Churg-Strauss syndrome, allergic granulomatosis, and allergic granulomatous angiitis. Sources included review articles, meta-analyses, randomized control trials, case reports, case series, and seminal articles, the majority of which had been published within the past decade.
  
  
  METHODS
  Studies that described the clinical manifestations, pathophysiology, etiology, treatment, or prognosis of CSS.
  
  
  RESULTS
  CSS is a systemic vasculitic disorder with multiorgan involvement and diverse presentations.
  
  
  CONCLUSIONS
  Recognition of the multiorgan manifestations of CSS is crucial to clinical management. Whether a causal relationship exists between antileukotriene antagonists and onset of CSS remains unclear.
authors: Division of Pulmonary and Critical Care Medicine and Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.
authors: G
authors: G
authors: Ramakrishna
authors: D E
authors: DE
authors: Midthun
mesh_terms: D015267:Churg-Strauss Syndrome / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D011379:Prognosis