Therapeutical effect of modified adamantane copolymer compounds: study of molecular mechanisms.
Copolymers of N-polyvinylpyrrolidone-acrylic acid (AB-1) and adamantane derivatives are known to possess marked antiviral activity in in vitro and in ovo models. Among the constructed preparations of AB-1 modified by adamantane derivatives some, especially AB-4 (modified by deitiforin), were found to show more extended antiviral activity and to inhibit markedly virus reproduction in susceptible permissive cell cultures and chicken embryos. In AB-4 treated cells and allantoic sacs, virus titers (influenza virus, herpes virus, and HIV) and virus antigen concentration were decreased. On the other hand, herpes virus-specific thymidine kinase and of DNA-polymerases isolated from Escherichia coli, Plectonema boryanum, and herpes virus type 1 infected murine brain tissue retained their activity after incubation with AB-4 or AB-2. The compounds investigated, in view of their effect on virus reproduction, are thought to be prospective as antiviral agents.
Rybalko
S
S
Lev Gromashevski Institute of Epidemiology and Infectious Diseases, Health Ministry of Ukraine, Kyiv.
Nesterova
N
N
Diadiun
S
S
Danylenko
G
G
Danylenko
V
V
Guzhova
S
S
Maksimov
Y
Y
Arkadiev
V
V
Ivans'ka
N
N
Maksymenok
O
O
Vrnycianu
N
N
Zhtrebtsova
E
E
Grygoreva
T
T
D000218:Adamantane / Q000737:chemistry*; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000821:virology; D002460:Cell Line; D002522:Chlorocebus aethiops; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D015195:Drug Design; D004926:Escherichia coli / Q000737:chemistry; D018259:Herpesvirus 1, Human / Q000378:metabolism; D006801:Humans; D007372:Interferons / Q000378:metabolism; D051379:Mice; D008956:Models, Chemical; D009975:Orthomyxoviridae / Q000378:metabolism; D011108:Polymers / Q000737:chemistry* / Q000633:toxicity; D013937:Thymidine Kinase / Q000378:metabolism; D014709:Vero Cells
D000998:Antiviral Agents; D011108:Polymers; D007372:Interferons; D013937:Thymidine Kinase; D004259:DNA-Directed DNA Polymerase; D000218:Adamantane