title: Intravenous leiomyomatosis of the uterus with multiple pulmonary metastases associated with large bullae-like cyst formation.
abstract: We present a case of uterine intravenous leiomyomatosis associated with multiple pulmonary metastases with bullae-like cystic change. A 53-year-old woman who had undergone hysterectomy 5 years previously underwent an operation for multiple pulmonary nodules with bullae formation. After resection of several large bullae, a subsequent extirpation of the pulmonary nodules was performed, and a pathological examination showed multiple leiomyomatous nodules with occasional cystic change. A review of the previous slides of the uterus and immunohistochemical analysis of the proliferating ability using anti-Ki-67 and anti-proliferating cell nuclear antigen (PCNA) antibodies were performed. Proliferating cells of the uterus had very few mitotic figures for their high cellularity, and the labeling indices of Ki-67 and PCNA indicated very low levels in both uterine neoplasm and pulmonary nodules. From these findings, an intravenous leiomyomatosis associated with multiple pulmonary metastases was diagnosed.
authors: Divisions of Pathology, Second Hospital of Nippon Medical School, Kanagawaken, Japan. koshi@nms.ac.jp
authors: K
authors: K
authors: Matsumoto
authors: T
authors: T
authors: Yamamoto
authors: T
authors: T
authors: Hisayoshi
authors: G
authors: G
authors: Asano
mesh_terms: D000199:Actins / Q000032:analysis; D001059:Apoproteins / Q000032:analysis; D003560:Cysts / Q000473:pathology; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000032:analysis; D018231:Leiomyomatosis / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D008175:Lung Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000556:secondary* / Q000601:surgery; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis; D009361:Neoplasm Invasiveness; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000032:analysis; D013902:Radiography, Thoracic; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone; D014057:Tomography, X-Ray Computed; D014594:Uterine Neoplasms / Q000737:chemistry / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014599:Uterus / Q000098:blood supply / Q000473:pathology
chemical_list: D000199:Actins; D001059:Apoproteins; D019394:Ki-67 Antigen; D018396:Mucin-1; D018809:Proliferating Cell Nuclear Antigen; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C046616:pulmonary surfactant apoprotein