Effectiveness of terbinafine in the eradication of Microsporum canis from laboratory cats.
In this study, the coats of 20 cats with no dermatophytosis lesions were sampled for colonization by Microsporum canis, which was isolated in 45% of cases. All cats were treated with oral terbinafine for 3 weeks. The drug was administered orally at a daily dosage 8.25 mg kg-1. Mycologic status was assessed at the end of the treatment; and after follow-up at 2 days, and 4 and 9 weeks. The final evaluation revealed a complete mycologic cure of all cats by obtaining negative cultures, thereby demonstrating that terbinafine is an effective method of eradication of dermatophyte colonization.
Castañón-Olivares
L R
LR
Departamento de Microbiología y Parasitología, Facultad de Medicina, Universidad Nacional Autónoma de México, México D. F.
Manzano-Gayosso
P
P
López-Martínez
R
R
De la Rosa-Velázquez
I A
IA
Soto-Reyes-Solís
E
E
D000284:Administration, Oral; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002415:Cats; D003881:Dermatomycoses / Q000188:drug therapy* / Q000382:microbiology / Q000635:transmission; D004195:Disease Models, Animal; D005260:Female; D005500:Follow-Up Studies; D008297:Male; D008864:Microsporum; D009281:Naphthalenes / Q000627:therapeutic use*; D000077291:Terbinafine
D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine