title: Five-year clinical course associated with DSM-IV alcohol abuse or dependence in a large group of men and women.
abstract: OBJECTIVE
  The prognostic validity of the DSM-IV diagnoses of alcohol abuse and alcohol dependence was evaluated by examining the 5-year clinical course associated with those diagnoses in a large group of predominantly blue-collar men and women.
  
  
  METHODS
  Personal semistructured interviews were carried out 5 years after an initial evaluation with 1,346 (75%) of the approximately 1,800 men and women participating in the Collaborative Study on the Genetics of Alcoholism who were eligible for follow-up.
  
  
  RESULTS
  About two-thirds of the 298 subjects with DSM-IV alcohol dependence at baseline maintained that diagnosis during the 5-year study period. Fifty-five percent of the 288 subjects with DSM-IV alcohol abuse at baseline continued to meet one or more of the 11 DSM-IV abuse/dependence criteria, and 3.5% went on to meet the criteria for dependence at follow-up. Among the 760 subjects with no alcohol diagnosis at baseline, 2.5% met the criteria for alcohol dependence and 12.8% for alcohol abuse at follow-up. Baseline characteristics that predicted the occurrence of any of the 11 DSM-IV abuse/dependence criteria during the 5-year interval included male gender, lack of marital stability, presence of several of the criteria for dependence, and history of illicit drug use.
  
  
  CONCLUSIONS
  The data suggest that over 5 years the DSM-IV diagnosis of alcohol dependence predicts a chronic disorder with a relatively severe course, while DSM-IV alcohol abuse predicts a less persistent, milder disorder that does not usually progress to dependence.
authors: Department of Psychiatry, University of California, San Diego 92161-2002, USA. mschuckit@ucsd.edu
authors: M A
authors: MA
authors: Schuckit
authors: T L
authors: TL
authors: Smith
authors: G P
authors: GP
authors: Danko
authors: K K
authors: KK
authors: Bucholz
authors: T
authors: T
authors: Reich
authors: L
authors: L
authors: Bierut
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000175:diagnosis* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011379:Prognosis; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D015203:Reproducibility of Results; D012737:Sex Factors; D012923:Social Class; D009626:Terminology as Topic; D014481:United States