Straight or split: signals to transcription.
Since the discovery of substance in serum media that are able to drive cells into proliferation and/or differentiation, investigators have tried to understand how such signalling molecules can influence cells to change their behaviour. The complex nature of the responses to signals, and the equally complex signalling pathway leading to those responses, have made life difficult for the researcher. However, recent evidence obtained in genetic developmental systems indicates that a multiplicity of downstream events can be accomplished by regulation of the activity of just one transcription factor.
van den Heuvel
M
M
MRC Functional Genetics Unit, Department of Human Anatomy and Genetics, University of Oxford, South Parks Road, Oxford OX1 3QX, UK. marcel.vandenheuvel@human-anatomy.oxford.ac.uk
D000818:Animals; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D006801:Humans; D019476:Insect Proteins / Q000502:physiology; D015398:Signal Transduction / Q000235:genetics*; D014157:Transcription Factors; D014158:Transcription, Genetic / Q000502:physiology*
D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins; D014157:Transcription Factors; C077245:hh protein, Drosophila