[Levels of selected soluble adhesion molecules in blood serum of children with chronic glomerulonephritis].
Increased concentrations of circulating soluble adhesion molecules have been reported in a variety of disorders. The aim of this study was to evaluate serum sICAM-1, sVCAM-1, sE-selectin, sP-selectin concentrations in 60 children with chronic glomerulonephritis GN (49 patients with GN and syndrome nephroticum, 11--with GN only), aged 3-17 years (mean 9 years) and in 15 healthy children (control group). The histopathological diagnoses of the 27 patients were: minimal change GN--10 cases, lupus nephritis--3, mesangiocapillary GN--4, mesangial GN--4, membranous GN--1, focal glomerulosclerosis--5. It was found a significant increase of tested soluble adhesion molecules in all children with GN compared to the control, independent on the histopathological type of GN. Serum sVCAM-1 and sP-selectin concentrations were higher in children with GN and syndrome nephroticum compared with patients with GN only. The results indicate activation of platelets, leucocytes, endothelium and its damage in GN. It seems, that more advanced vascular endothelium changes and platelets activation occur in children with GN and syndrome nephroticum.
Kiliś-Pstrusińska
K
K
Katedra i Klinika Nefrologii Pediatrycznej Akademii Medycznej we Wrocławiu.
Medyńska
A
A
Wikiera-Magott
I
I
Zwolińska
D
D
D000293:Adolescent; D015815:Cell Adhesion Molecules / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D019040:E-Selectin / Q000097:blood; D005260:Female; D005921:Glomerulonephritis / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood; D008297:Male; D009404:Nephrotic Syndrome / Q000378:metabolism; D019007:P-Selectin / Q000097:blood; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D019007:P-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1