Molecular genetic analysis and biochemical characterization of mammalian P-glycoproteins involved in multidrug resistance.
A variety of human cancers become resistant or are intrinsically resistant to treatment with conventional drug therapies. This phenomenon is due in large part to the overexpression of a 170 kDa plasma membrane ATP-dependent pump known as the multidrug resistance transporter or P-glycoprotein. P-glycoprotein is a member of the large ATP binding cassette (ABC) superfamily of membrane transporters. This review focuses on the use of structure-function analyses to elucidate further the mechanism of action of mammalian P-glycoproteins. Ultimately, a complete understanding of the mechanism is important for the development of novel strategies for the treatment of many human cancers.
Hrycyna
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Department of Chemistry, Purdue University, 1393 Brown Building, West Lafayette, IN 47907-1393, USA. hrycyna@purdue.edu
D018435:ATP Binding Cassette Transporter, Subfamily B / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000818:Animals; D018432:Drug Resistance, Multiple; D006801:Humans; D008322:Mammals; D009154:Mutation
D018435:ATP Binding Cassette Transporter, Subfamily B