Estradiol is a neuroprotective factor in in vivo and in vitro models of brain injury.
Many clinical studies suggest that estrogen enhances memory and cognition and protects against neurodegenerative diseases and injury associated with stroke or stress. These results are strongly supported by experiments performed in animal models using both in vivo and in vitro methods. We present here data from our lab that establishes that physiological levels of estradiol exert profound protective actions against ischemic injury. Further we will present evidence that these effects may be mediated through estrogen receptors that may influence the bcl-2 family of genes.
Wise
P M
PM
Department of Physiology, College of Medicine, University of Kentucky, Lexington 40536, USA.
Dubal
D B
DB
Wilson
M E
ME
Rau
S W
SW
D000818:Animals; D001930:Brain Injuries / Q000378:metabolism*; D004195:Disease Models, Animal; D004958:Estradiol / Q000378:metabolism*; D066298:In Vitro Techniques; D018696:Neuroprotective Agents / Q000378:metabolism*
D018696:Neuroprotective Agents; D004958:Estradiol