title: Hayflick, his limit, and cellular ageing.
abstract: Almost 40 years ago, Leonard Hayflick discovered that cultured normal human cells have limited capacity to divide, after which they become senescent -- a phenomenon now known as the 'Hayflick limit'. Hayflick's findings were strongly challenged at the time, and continue to be questioned in a few circles, but his achievements have enabled others to make considerable progress towards understanding and manipulating the molecular mechanisms of ageing.
authors: University of Texas Southwestern Medical Center at Dallas, Department of Cell Biology, 5323 Harry Hines Boulevard, Dallas, Texas 75390-9039, USA. shay@utsw.swmed.edu
authors: J W
authors: JW
authors: Shay
authors: W E
authors: WE
authors: Wright
mesh_terms: D000375:Aging; D002455:Cell Division; D002478:Cells, Cultured / Q000502:physiology*; D016922:Cellular Senescence; D049672:History, 19th Century; D049673:History, 20th Century; D049674:History, 21st Century; D006801:Humans; D019098:Telomerase / Q000378:metabolism; D016615:Telomere / Q000502:physiology; D013997:Time Factors; D014481:United States
chemical_list: D019098:Telomerase