Ran GTPase cycle: oOne mechanism -- two functions.
The Ras-related GTPase Ran functions in nucleocytoplasmic transport by regulating interactions of transport receptors with transport cargo. Three recent studies suggest that Ran uses exactly the same mechanism to regulate spindle assembly during mitosis.
Melchior
F
F
Max-Planck Institute for Biochemistry, Am Klopferspitz 18a, 82152, Martinsried, Germany. melchoir@biochem.mpg.de
D000818:Animals; D001693:Biological Transport, Active; D018797:Cell Cycle Proteins; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004261:DNA Replication; D020662:Guanine Nucleotide Exchange Factors / Q000378:metabolism; D007399:Interphase; D028884:Karyopherins; D008938:Mitosis / Q000502:physiology; D008954:Models, Biological; D009687:Nuclear Proteins / Q000378:metabolism; D009865:Oocytes / Q000166:cytology; D021381:Protein Transport; D008941:Spindle Apparatus / Q000378:metabolism*; D029867:Xenopus Proteins; D014982:Xenopus laevis; D020931:ran GTP-Binding Protein / Q000378:metabolism*; D020703:ras GTPase-Activating Proteins / Q000378:metabolism
D018797:Cell Cycle Proteins; D020662:Guanine Nucleotide Exchange Factors; D028884:Karyopherins; D009687:Nuclear Proteins; C499304:RCC1 protein, Xenopus; D029867:Xenopus Proteins; D020703:ras GTPase-Activating Proteins; D020931:ran GTP-Binding Protein