A new diterpene from Hypoestes serpens.
From a defatted chloroform extract of the aerial parts of Hypoestes serpens a new diterpene exhibiting relaxant activity on isolated rat aorta was obtained. The structure of this compound, named serpendione (1), was fully established by the interpretation of its spectral data.
Andriamihaja
B
B
Faculté des Sciences, Université d'Antananarivo, B.P. 906, 101-Antananarivo, Madagascar, Institut de Chimie des Substances Naturelles (ICSN-CNRS), Avenue de la Terrasse, 91198-Gif-sur-Yvette, France.
Martin
M T
MT
Rasoanaivo
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P
Frappier
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F
D000818:Animals; D001011:Aorta / Q000187:drug effects; D002725:Chloroform; D034242:Cyclooctanes; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D008956:Models, Chemical; D009126:Muscle Relaxation / Q000187:drug effects*; D051381:Rats; D013055:Spectrophotometry, Infrared; D014664:Vasodilation / Q000187:drug effects*; D014665:Vasodilator Agents / Q000302:isolation & purification* / Q000494:pharmacology
D034242:Cyclooctanes; D004224:Diterpenes; D014665:Vasodilator Agents; C433581:serpendione; D002725:Chloroform