Hydrogen excretion upon ingestion of dairy products in lactose-intolerant male subjects: importance of the live flora.
OBJECTIVE
To assess the effects of the ingestion of milk, yoghurt (10(8) bacteria/ml), heat-treated yoghurt (<15 bacteria/ml) and two products obtained by dilution of yoghurt with heat-treated product (10(6) and 10(5) bacteria/ml) on hydrogen production and symptoms of lactose intolerance in lactose malabsorbers.


METHODS
Double-blind, randomised cross-over design.


METHODS
The study was performed in the phase 1 clinical unit of OPTIMED, Nancy, France.


METHODS
Twenty-four male lactose malabsorbers were selected for the study.


METHODS
Hydrogen production and adverse events were followed during 8 h after ingestion of the products.


RESULTS
The results clearly demonstrate that ingestion of yoghurt with 10(8) bacteria/ml leads to lower H(2) excretion and complaints than the other products. Results observed with the products containing a reduced population of live flora remain better than those observed with milk.


CONCLUSIONS
The importance of a high population of the live flora is underlined.
Pelletier
X
X
OPTIMED, Gières, France. OPTIMED54@aol.com
Laure-Boussuge
S
S
Donazzolo
Y
Y
D000328:Adult; D000818:Animals; D001944:Breath Tests; D015169:Colony Count, Microbial; D018592:Cross-Over Studies; D003611:Dairy Products / Q000382:microbiology*; D004311:Double-Blind Method; D006801:Humans; D006859:Hydrogen / Q000378:metabolism*; D007785:Lactose / Q000378:metabolism*; D007787:Lactose Intolerance / Q000503:physiopathology*; D008297:Male; D008892:Milk / Q000382:microbiology; D013696:Temperature; D013997:Time Factors; D015014:Yogurt / Q000382:microbiology
D006859:Hydrogen; D007785:Lactose