Chromatin remodelling and DNA replication: from nucleosomes to loop domains.
Organization of DNA into chromatin is likely to participate in the control of the timing and selection of DNA replication origins. Reorganization of the chromatin is carried out by chromatin remodelling machines, which may affect the choice of replication origins and efficiency of replication. Replication itself causes a profound rearrangement in the chromatin structure, from nucleosomes to DNA loop domains, allowing to retain or switch an epigenetic state. The present review considers the effects of chromatin remodelling on replication and vice versa.
Demeret
C
C
Institute of Human Genetics, CNRS, 141, rue de la Cardonille, 34396 Montpellier Cedex 5, France.
Vassetzky
Y
Y
Méchali
M
M
D000818:Animals; D002843:Chromatin / Q000235:genetics* / Q000378:metabolism; D004247:DNA / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D004250:DNA Topoisomerases, Type II / Q000378:metabolism; D006801:Humans; D009690:Nucleic Acid Conformation; D009707:Nucleosomes / Q000235:genetics / Q000378:metabolism
D002843:Chromatin; D009707:Nucleosomes; D004247:DNA; D004250:DNA Topoisomerases, Type II