Steroid-induced hypertrophic cardiomyopathy following stem cell transplantation in a neonate: a case report.
We report a case of severe left ventricular outflow tract obstruction complicating steroid therapy in an infant undergoing allogeneic transplant in the first few weeks of life for treatment of Krabbe's disease. While this complication is well known to those treating premature infants, it has not been reported in the stem cell transplant setting. For young infants undergoing allogeneic transplant who require steroid therapy, cardiac monitoring after 2--3 weeks of therapy is recommended.
Lesnik
J J
JJ
Department of Pediatrics, Saint Louis University School of Medicine, Cardinal Glennon Children's Hospital, St Louis, MO, USA.
Singh
G K
GK
Balfour
I C
IC
Wall
D A
DA
D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D002312:Cardiomyopathy, Hypertrophic / Q000139:chemically induced* / Q000517:prevention & control; D004562:Electrocardiography; D005260:Female; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007231:Infant, Newborn; D007965:Leukodystrophy, Globoid Cell / Q000150:complications / Q000175:diagnosis / Q000628:therapy*; D008775:Methylprednisolone / Q000008:administration & dosage / Q000009:adverse effects; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014184:Transplantation, Homologous; D018487:Ventricular Dysfunction, Left / Q000209:etiology
D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone