Immunohistochemical and morphometric analysis of effects of vilon and epithalon on functional morphology of radiosensitive organs.
Studies of the effects of vilon and epithalon on functional morphology of the thymus, spleen, and duodenum in intact rats and rats exposed to single whole-body gamma-irradiation in a dose of 6 Gy showed that vilon stimulated proliferative activity of thymocytes and enhanced proliferative potential of stem cells in the intestine, thus stimulating the postradiation recovery of critical organs. Epithalon decelerated metabolic processes in the duodenal mucosa and suppressed hemopoiesis and lymphopoiesis in the spleen.
Khavinson
V K
VK
St. Petersburg Institute of Bioregulation and Gerontology, North-Western Division of Russian Academy of Medical Sciences, Russian Academy of Medical Sciences, Obninsk.
Yuzhakov
V V
VV
Kvetnoi
I M
IM
Malinin
V V
VV
Popuchiev
V V
VV
Fomina
N K
NK
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology*; D002455:Cell Division; D004151:Dipeptides / Q000494:pharmacology*; D004386:Duodenum / Q000166:cytology / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects*; D005720:Gamma Rays; D007150:Immunohistochemistry; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D011836:Radiation Tolerance; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000166:cytology / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects*; D013234:Stem Cells / Q000166:cytology / Q000528:radiation effects; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism / Q000502:physiology / Q000528:radiation effects*
D001685:Biological Factors; D004151:Dipeptides; D009842:Oligopeptides; D018809:Proliferating Cell Nuclear Antigen; C415909:lysylglutamic acid; C421253:alanyl-glutamyl-aspartyl-glycine