title: Antifeedant constituents from Fagara macrophylla.
abstract: Analysis of the polar fractions of an EtOH extract obtained from the bark of the African medicinal plant Fagara macrophylla led to the isolation and identification of the alkaloids oblongine (6), tembetarine (7) and magnoflorine (8) and the flavonoid hesperidin (9). These compounds, together with other metabolites (1--5) previously isolated from F. macrophylla, were tested for antifeedant activity in a binary-choice bioassay. The acridone alkaloid xanthoxoline (4) was found to have a potent antifeedant activity against larvae of both Spodoptera frugiperda and S. littoralis. 1-Hydroxy-3-methoxy-N-methyl-acridone (2), arborinine (3), tembetarine (7) and magnoflorine (8) were antifeedant against S. frugiperda.
authors: Dipartimento di Scienze Chimiche, Università di Catania, Viale A. Doria 6, Catania I-95125, Italy. ctringali@dipchi.unict.it
authors: C
authors: C
authors: Tringali
authors: C
authors: C
authors: Spatafora
authors: V
authors: V
authors: Calì
authors: M S
authors: MS
authors: Simmonds
mesh_terms: D000098:Acetophenones / Q000494:pharmacology; D000166:Acridines / Q000494:pharmacology; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001060:Aporphines / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects*; D007306:Insecticides / Q000494:pharmacology*; D007814:Larva / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D018547:Plant Stems; D010946:Plants, Medicinal; D019685:Rosales; D018411:Spodoptera / Q000187:drug effects*
chemical_list: C432975:1-hydroxy-3-methoxy-N-methylacridone; D000098:Acetophenones; D000166:Acridines; D000470:Alkaloids; D001060:Aporphines; D007306:Insecticides; D010936:Plant Extracts; C432976:xanthoxoline; C003383:tembetarine; C022784:arborinine; C001670:magnoflorine; C064382:xanthoxyline