[Peroxidation of lipids and activity of antioxidant enzymes in children with nephritic syndrome].
The aim of the study was to estimate antioxidant status and reliable factors involved in antioxidant protection in children with nephrotic syndrome (NS). 37 children (20 boys, 17 girls) with nephrotic syndrome (NS), aged 2.5-17 (mean 9.5), were included into the study. Erythrocyte Superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), reduced glutathione (GSH) and malonylodialdehide (MDA) was estimated using commercial kits produced by Calbiochem and Bioxytech.


RESULTS
1) Decreased mean values of following parameters in children with NS--acute phase comparing to remission phase and the control group: GSH-Px (123.88 +/- 25.02; 187.69 +/- 24.57; 266.49 +/- 21.84 mU/ml; p < 0.001), GSH: (16.6 +/- 5.99; 27.81 +/- 7.68; 43.79 +/- 7.21 mumol/L; p < 0.001). 2) Increased mean values of following parameters in adequate groups: MDA: (18.70 +/- 2.01; 14.63 +/- 1.51; 9.53 +/- 1.48 mumol, p < 0.001), SOD: 536.27 +/- 450.49; 387.16 +/- 219.49; 236.96 +/- 85.71 U/mg).


CONCLUSIONS
there is increased lipid peroxidation and insufficient antioxidant defence in children with nephrotic syndrome.
Mader-Wołyńska
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I
Katedra i Klinika Nefrologii Pediatrycznej Akademii Medycznej we Wrocławiu.
Zwolińska
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D
D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009404:Nephrotic Syndrome / Q000378:metabolism*; D013482:Superoxide Dismutase / Q000378:metabolism
D000975:Antioxidants; D015415:Biomarkers; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005978:Glutathione