title: Thalibealine, a novel tetrahydroprotoberberine--aporphine dimeric alkaloid from Thalictrum wangii.
abstract: A novel tetrahydroprotoberberine-aporphine dimeric alkaloid, (-)-thalibealine (1), was isolated from the roots of Thalictrum wangiii, and its structure established via spectroscopic analysis. Three other alkaloids were isolated, including the benzyltetrahydroisoquinoline-aporphine dimer (+)-thalmelatidine, the aporphine (+)-magnoflorine, and the protoberberine berberine. This is the first reported isolation of a tetrahydroprotoberberine-aporphine dimer from nature, as well as the first reported isolation of constituents from Thalictrum wangii.
authors: Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania 15261, USA.
authors: T A
authors: TA
authors: Al-Howiriny
authors: M A
authors: MA
authors: Zemaitis
authors: C Y
authors: CY
authors: Gao
authors: C E
authors: CE
authors: Hadden
authors: G E
authors: GE
authors: Martin
authors: F T
authors: FT
authors: Lin
authors: P L
authors: PL
authors: Schiff
mesh_terms: D001600:Berberine Alkaloids / Q000737:chemistry*; D002681:China; D002855:Chromatography, Thin Layer; D009682:Magnetic Resonance Spectroscopy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D017550:Spectroscopy, Fourier Transform Infrared
chemical_list: D001600:Berberine Alkaloids; C433623:thalibealine