Idiopathic polymyositis and glomerulonephritis.
We report a 28-year-old male who presented with a clinical picture compatible with idiopathic polymyositis and nephrotic-range proteinuria. Muscle biopsy confirmed the diagnosis of polymyositis and a diagnostic renal biopsy demonstrated IgM mesangial glomerulonephritis. Following a short-course of prednisone, both the myositis and proteinuria resolved. Glomerulonephritis associated with idiopathic polymyositis is rare; however, since it appeared to respond to corticosteroid therapy concomitant with the improvement in the myositis, it was likely an associated immunological complication.
Valenzuela
O F
OF
Division of Nephrology and Hypertension, Brookdale University Hospital and Medical Center, Brooklyn, NY, USA.
Reiser
I W
IW
Porush
J G
JG
D000328:Adult; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D005921:Glomerulonephritis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007677:Kidney Function Tests; D008297:Male; D008853:Microscopy; D017285:Polymyositis / Q000150:complications* / Q000188:drug therapy / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D016896:Treatment Outcome
D011241:Prednisone