[Elevated cortisol level in blood of patients with unstable coronary disease and acute myocardial infarction--new approach].
The aim of this study was to assess changes in serum cortisol concentration, enzymatic markers of myocardial ischemia and necrosis, leucocytosis and glucose in patients with unstable coronary disease and acute myocardial infarction. The study was performed in 75 patients (20 females and 55 males aged 38-75 years; mean age 59.4 +/- 6.52), including 13 patients with unstable coronary disease (6 females and 7 males aged 40-66 years; mean age 59.4 +/- 6.52; group I), 40 patients with acute myocardial infarction (8 females and 32 males aged 38-72 years; mean age 57.3 +/- 9.57; group II) and 22 healthy volunteers (6 females and 16 males aged 39-75 years; mean age 53.1 +/- 9.62; control group). Acute ischemia as well as myocardial infarction are potent stress factors that destabilisate the functional equilibrium of the body. Considering the mechanism of action of cortisol and its physiological role, it seems that current views on elevated plasma cortisol levels as a response to stress and pain in infarction and acute ischemia should be supplemented. Anti-inflammatory properties of cortisol deserve more attention, while elevated levels might be of prognostic value in the above-mentioned diseases.
Domański
L
L
Klinika Chorób Wewnetrznych, PAM w Szczecinie.
Pietrzak-Nowacka
M
M
Szmatłoch
E
E
Wójcicki
J
J
D000328:Adult; D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000378:metabolism; D003327:Coronary Disease / Q000097:blood* / Q000150:complications; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications; D010146:Pain / Q000150:complications / Q000503:physiopathology; D010147:Pain Measurement; D011379:Prognosis; D013312:Stress, Physiological / Q000097:blood / Q000150:complications
D015415:Biomarkers; D001786:Blood Glucose; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D006854:Hydrocortisone