title: Improvement of sleep apnea in a patient with cerebral palsy.
abstract: Intrathecal baclofen (ITB) can reduce spasticity in adults and children with cerebral palsy. Benefits of ITB therapy include improved Ashworth scores, activities of daily living, and mobility. The impact of ITB therapy on sleep apnea in patients with cerebral palsy has not been reported. This case report describes a 29-yr-old female with mixed spastic athetoid quadriparetic cerebral palsy with dystonia, gross motor function IV, who had sleep apnea, requiring nightly continuous positive airway pressure. She received ITB with the goal to improve her wheelchair positioning and decrease her excessive movements. After the initiation of the ITB, reduction of her spasticity and dystonia was noted, as well as improvement of her sleep apnea. This case suggests that ITB therapy may improve respiratory function through reduction of respiratory muscle spasticity.
authors: Rehabilitation Institute of Chicago, Northwestern University Medical School, Illinois, USA.
authors: S F
authors: SF
authors: McCarty
authors: D
authors: D
authors: Gaebler-Spira
authors: R L
authors: RL
authors: Harvey
mesh_terms: D000328:Adult; D001418:Baclofen / Q000627:therapeutic use*; D002547:Cerebral Palsy / Q000150:complications* / Q000188:drug therapy*; D004421:Dystonia / Q000209:etiology; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D009128:Muscle Spasticity / Q000209:etiology; D017286:Polysomnography; D011175:Positive-Pressure Respiration; D011782:Quadriplegia / Q000209:etiology; D020181:Sleep Apnea, Obstructive / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy
chemical_list: D001418:Baclofen