Enhanced intra-abdominal visceral fat accumulation in patients with Werner's syndrome.
OBJECTIVE
Studies were made on the abnormality of glucose and lipid metabolism and its cause in four patients with Werner's syndrome to infer the reason for accelerated atherogenesis in this syndrome.


RESULTS
Of these four patients, hypercholesterolemia was found in three, hypertriglyceridemia in four, hypoalphalipoproteinemia in two and hypertension in two. All the patients had insulin-resistant diabetes mellitus and three of them had apparent hyperinsulinemia. Abdominal computed tomography revealed that all of them had visceral fat obesity, namely augumented intra-abdominal adipose tissue.


CONCLUSIONS
The clinical features of these patients resemble those recently designated as insulin resistant syndrome (syndrome X) or visceral fat syndrome. The metabolic abnormality may be one of important factors in the accelerated atherogenesis in this syndrome.
Mori
S
S
Second Department of Internal Medicine, School of Medicine, Chiba University, Inohana, Chiba, Japan. seimori@intmed02.m.chiba-u.ac.jp
Murano
S
S
Yokote
K
K
Takemoto
M
M
Asaumi
S
S
Take
A
A
Saito
Y
Y
D000005:Abdomen; D000273:Adipose Tissue / Q000033:anatomy & histology*; D000328:Adult; D001161:Arteriosclerosis / Q000209:etiology*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D006949:Hyperlipidemias / Q000378:metabolism; D007333:Insulin Resistance; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed; D014898:Werner Syndrome / Q000378:metabolism* / Q000503:physiopathology
D005947:Glucose