title: Normal plasma levels of orexin A (hypocretin-1) in narcoleptic patients.
abstract: Deficient orexin signaling has been shown to cause narcolepsy-like conditions in animals. In human narcolepsy, CSF levels of orexin A (hypocretin-1) were reported to be low in most cases. The authors measured CSF and plasma orexin A levels in patients with narcolepsy and in controls. Confirming earlier studies, they found CSF orexin A levels to be extremely low in patients with narcolepsy. However, plasma orexin A levels did not differ from those observed in controls. These results suggest that orexin deficiency in patients with narcolepsy is a phenomena restricted to the CNS.
authors: Max Planck Institute of Psychiatry, Munich, Germany.
authors: M A
authors: MA
authors: Dalal
authors: A
authors: A
authors: Schuld
authors: M
authors: M
authors: Haack
authors: M
authors: M
authors: Uhr
authors: P
authors: P
authors: Geisler
authors: I
authors: I
authors: Eisensehr
authors: S
authors: S
authors: Noachtar
authors: T
authors: T
authors: Pollmächer
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000097:blood* / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D008875:Middle Aged; D009290:Narcolepsy / Q000097:blood* / Q000134:cerebrospinal fluid*; D009479:Neuropeptides / Q000097:blood* / Q000134:cerebrospinal fluid*; D000068797:Orexins; D011863:Radioimmunoassay
chemical_list: D002352:Carrier Proteins; C000596229:HCRT protein, human; D047908:Intracellular Signaling Peptides and Proteins; D009479:Neuropeptides; D000068797:Orexins