[Correlation of somatotropic hormone with post-infarction myocardial remodelling and clinical prognosis in patients with myocardial infarction].
To evaluate pathogenetic link of ischemic heart dysfunction with the level of endogenic STH in myocardial infarction (MI) patients at different MI stages and to specify prognostic value of STH for MI outcomes, we examined 78 males on MI day 21-26, month 3-6 and a year later. 20 healthy males served control and 17 patients with ischemic heart diseases without MI according to coronaroventriculography (CVG) were a comparison group. STH was measured in all the patients with radioimmunoassay, CVG was made according to M. Judkins. We found that in patients with high level of endogenic STH (> 1 nm/l) within the first postmyocardial infarction month development of reparative and adaptive fibrosis continues 3 to 6 months and is more favorable. If STH physiological level maintains, myocardial contractility remains satisfactory for a long period. In high STH levels, patients with myocardial ischemia more frequently exhibit ventricular arrhythmia. Low STH blood levels lead to left ventricular dilatation, deterioration of cardiac contractility, stenotic coronary atherosclerosis, intracardiac hemodynamics and IHD clinical course. Lethal outcomes occur more frequently.
Tepliakov
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AT
Telkova
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IL
Karpov
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RS
D000328:Adult; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D002908:Chronic Disease; D013006:Growth Hormone / Q000097:blood*; D006333:Heart Failure / Q000097:blood / Q000209:etiology / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications / Q000473:pathology* / Q000503:physiopathology; D009206:Myocardium / Q000473:pathology*; D011237:Predictive Value of Tests; D011379:Prognosis; D017180:Tachycardia, Ventricular / Q000097:blood / Q000209:etiology / Q000473:pathology; D013997:Time Factors
D015415:Biomarkers; D013006:Growth Hormone