title: A comparison of brain, core and skin temperature in children with complicated and uncomplicated malaria.
abstract: A prospective study was carried out in which brain, core and skin temperatures were studied in children with cerebral malaria (n = 23), uncomplicated malaria (n = 12) and normal children (n = 9) using the zero heat flow method. Patients with cerebral or uncomplicated malaria were admitted to the paediatric wards (mean age, 6 years 8 months +/- 2 years 8 months). Normal children, children of the investigators, of the same age group, served as controls. Parasitaemia levels were similar in the cerebral and uncomplicated malaria cases. Higher brain than core temperatures would have been expected in cerebral malaria but not in uncomplicated malaria but this was not the case in this study. There was no statistical difference in brain, core and skin temperature between cerebral and uncomplicated malaria patients. However, there was a highly significant difference between normal children and cerebral and uncomplicated malaria patients. Brain temperature was 0.02-0.2 degrees C below core temperature in all the groups with larger differences during the febrile period. Mean differences of brain minus core, brain minus skin and core minus skin between the two groups of patients were not statistically significant. There was no correlation between temperature and the level of coma or parasitaemia for cerebral and uncomplicated malaria patients. There was a positive correlation between brain and core temperature in both groups of patients during the febrile phase. Brain temperature remained lower than core temperature in cerebral and uncomplicated malaria as in normal children. Normal thermoregulation appears to be maintained in cerebral malaria.
authors: Department of Child Health and Paediatrics, Faculty of Health Sciences, Moi University, Kenya.
authors: F
authors: F
authors: Esamai
authors: S
authors: S
authors: Mining
authors: P
authors: P
authors: Forsberg
authors: D H
authors: DH
authors: Lewis
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use; D001831:Body Temperature; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007630:Kenya; D016779:Malaria, Cerebral / Q000145:classification / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D011446:Prospective Studies; D011803:Quinine / Q000627:therapeutic use; D012881:Skin Temperature
chemical_list: D000962:Antimalarials; D011803:Quinine