title: Spinal-Cord plasticity: independent and interactive effects of neuromodulator and activity-dependent plasticity.
abstract: Plasticity is one of the most extensively studied aspects in neuroscience. Interest in it has primarily been related to its proposed role in learning and memory and its relevance to adaptive changes following injury. Plasticity can be evoked by changes in molecular, cellular, and synaptic properties, either as a result of activity-dependent effects, or by relatively slow-acting neuromodulatory transmitters. In addition, it is increasingly recognized that the plasticity evoked by these individual effects can be altered by previous inputs and is thus itself plastic. Here, I will review studies in the lamprey spinal cord that have examined individual and interactive activity-dependent and neuromodulator-mediated plasticity. The results show that activity-dependent and neuromodulator-mediated plasticity evoke neuron-and synapse-specific effects at different levels in the spinal cord, and that interactions within and between these effects can evoke dynamic changes in cellular, synaptic, and network plasticity.
authors: University of Cambridge, Department of Zoology.
authors: D
authors: D
authors: Parker
mesh_terms: D000200:Action Potentials; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001933:Brain Stem / Q000502:physiology; D020013:Calcium Signaling; D004525:Efferent Pathways / Q000502:physiology; D005071:Evoked Potentials; D019706:Excitatory Postsynaptic Potentials / Q000187:drug effects / Q000502:physiology; D007395:Interneurons / Q000502:physiology; D015640:Ion Channel Gating / Q000502:physiology; D007798:Lampreys / Q000033:anatomy & histology / Q000502:physiology*; D008124:Locomotion / Q000502:physiology; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology; D009473:Neuronal Plasticity; D009475:Neurons, Afferent / Q000502:physiology; D009479:Neuropeptides / Q000494:pharmacology / Q000502:physiology; D010507:Periodicity; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology; D013116:Spinal Cord / Q000502:physiology*; D013569:Synapses / Q000502:physiology; D009435:Synaptic Transmission
chemical_list: D009479:Neuropeptides; D016194:Receptors, N-Methyl-D-Aspartate; D012701:Serotonin