The effect of acidosis on the ECG of the rat heart.
We have investigated the effect of acidosis on the ECG in isolated rat heart to determine whether acidosis has marked effects on the ECG, and have used pharmacological agents to investigate possible mechanisms whereby acidosis alters the ECG. Acidosis produced a marked decrease in heart rate and an increase in P-R interval with little apparent effect on the duration of the QRS complex. The effects of acidosis did not appear to be due to acidosis-induced changes in transmitter release from severed autonomic nerve terminals within the heart. Experimental Physiology (2001) 86.1, 27-31.
Aberra
A
A
Faculty of Medicine, Addis Ababa University, PO Box 9886, Addis Ababa, Ethiopia.
Komukai
K
K
Howarth
F C
FC
Orchard
C H
CH
D015761:4-Aminopyridine / Q000494:pharmacology; D000138:Acidosis / Q000503:physiopathology*; D000318:Adrenergic beta-Agonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D018680:Cholinergic Antagonists / Q000494:pharmacology; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000318:Adrenergic beta-Agonists; D018680:Cholinergic Antagonists; D001285:Atropine; D011433:Propranolol; D015761:4-Aminopyridine