[Anticancer properties of flagellate protozoan Trypanosoma cruzi Chagas, 1909].
The anticancer activity of Trypanosoma cruzi has been confirmed by the example of seven strains. Five virulent strains induced the infection, which inhibited sarcoma-180 growth 1.5-22.0 times. The parasites featured tumortropism; i.e., the successfully developed in cancer cells and even preferred them to normal cells. This taxis-based phenomenon was particularly pronounced at cocultivation of the normal and cancer cells. Cultures of the seven (avirulent and virulent) strains can produce an anticancer agent that selectively damages human cancer cells in vitro. The long-term anticancer effect of T. cruzi or preparations from it, as well as possible its cancer preventing effect, has been demonstrated. Three problems are discussed on the basis of the obtained and recently published data: (1) the mechanism of T. cruzi anticancer effect; (2) the nature of the anticancer agent; and (3) the distribution of the considered phenomenon among trypanosomatides. The anticancer activity of T. cruzi may be due to a combination of surface cellular antigens and an inhibiting or lysing factor.
Kallinikova
V D
VD
Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.
Matekin
P V
PV
Ogloblina
T A
TA
Leĭkina
M I
MI
Kononenko
A F
AF
Sokolova
N M
NM
Pogodina
L S
LS
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000378:metabolism* / Q000494:pharmacology; D000953:Antigens, Protozoan / Q000378:metabolism; D000954:Antigens, Surface / Q000378:metabolism; D001685:Biological Factors / Q000378:metabolism* / Q000494:pharmacology; D014355:Chagas Disease / Q000276:immunology / Q000469:parasitology*; D006801:Humans; D009368:Neoplasm Transplantation; D009369:Neoplasms / Q000276:immunology / Q000469:parasitology / Q000473:pathology*; D009928:Organ Specificity; D009930:Organic Chemicals; D014349:Trypanosoma cruzi / Q000276:immunology / Q000378:metabolism* / Q000472:pathogenicity; D014774:Virulence
D000903:Antibiotics, Antineoplastic; D000953:Antigens, Protozoan; D000954:Antigens, Surface; D001685:Biological Factors; D009930:Organic Chemicals; C007155:cruzin