[Characteristics of expression of active oxygen forms by blood cells in patients with chronic bronchitis].
OBJECTIVE
To study generation of active oxygen forms in the whole blood of patients with chronic bronchitis and correction of the detected disorders.


METHODS
By means of registration of spontaneous and staphylococcus-induced luminol-dependent chemiluminescence (LDCL) of the whole blood, generation of active oxygen forms in 73 patients with chronic bronchitis (CB) has been studied.


RESULTS
By the intensity of luminescence, all the examinees were divided into two groups. In group 1 LDCL was high, in group 2 LDCL was under the control level. Combined treatment of group 1 patients included inhalations of ceruloplasmin antioxidant. Patients of group 2 were administered sodium hypochlorite that possesses prooxidation properties. Compared to conventional treatment, the above two treatments produced marked positive changes in the studied indices and clinical symptoms.


CONCLUSIONS
The method of chemiluminescence registration of the whole blood allows validation of pathogenetic therapy of patients with CB and improves outcomes of the treatment.
Abdrakhmanova
L M
LM
Farkhutdinov
U R
UR
Farkhutdinov
R R
RR
D000328:Adult; D000975:Antioxidants / Q000008:administration & dosage* / Q000494:pharmacology; D001773:Blood Cells / Q000187:drug effects; D001782:Blood Donors; D001991:Bronchitis / Q000097:blood* / Q000628:therapy*; D002570:Ceruloplasmin / Q000008:administration & dosage* / Q000494:pharmacology; D002908:Chronic Disease; D003627:Data Interpretation, Statistical; D004202:Disinfectants / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D008163:Luminescent Measurements; D008875:Middle Aged; D017382:Reactive Oxygen Species; D012138:Respiratory Therapy; D012973:Sodium Hypochlorite / Q000008:administration & dosage* / Q000494:pharmacology
D000975:Antioxidants; D004202:Disinfectants; D017382:Reactive Oxygen Species; D012973:Sodium Hypochlorite; D002570:Ceruloplasmin