Potentiation of BCNU cytotoxicity by molecules targeting abasic lesions in DNA.
We describe the synthesis, DNA binding measurements and pharmacological properties of a series of new heterodimeric molecules, in which a 2,6-diaminopurine is linked to a 9-aminoacridine chromophore. The linking chain contains a central N,N'-disubstituted guanidine, connected to the two chromophores by polymethylenic units of variable length.
Alarcon
K
K
LEDSS, Chimie Bioorganique, UMR CNRS 5616, Université Joseph Fourier, BP53, 38041 Grenoble cedex 9, France.
Demeunynck
M
M
Lhomme
J
J
Carrez
D
D
Croisy
A
A
D000230:Adenocarcinoma / Q000473:pathology; D000818:Animals; D018906:Antineoplastic Agents, Alkylating / Q000494:pharmacology*; D002330:Carmustine / Q000494:pharmacology*; D002417:Cattle; D004247:DNA / Q000187:drug effects*; D006801:Humans; D007939:Leukemia L1210 / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D014407:Tumor Cells, Cultured
D018906:Antineoplastic Agents, Alkylating; D004247:DNA; D002330:Carmustine