title: Gallstones and laparoscopic cholecystectomy in hepatitis C patients.
abstract: Our aims were to determine the incidence of gallstones in a cohort of patients infected with hepatitis C for 20 years, and to analyse the outcome of all patients infected with hepatitis C undergoing laparoscopic cholecystectomy. A hepatitis C screening programme in place in Ireland since 1994 identified 965 patients with hepatitis C antibodies out of 62,667 patients screened. The hepatology unit of Cork University Hospital has 318 patients with hepatitis C. Of patients identified by screening, 201 were post partum women infected via contaminated Anti-D immunoglobulin administered in 1977. Thirty-five (17.4%) of two hundred and one patients with hepatitis C since 1977 had developed gallstones after twenty years. A total of 34 patients with hepatitis C underwent laparoscopic cholecystectomy. One patient required conversion to open cholecystectomy. There were no complications and no mortality. There was a low rate of cirrhosis (11%) on examining liver histology. The incidence of gallstones in a cohort of patients infected with hepatitis C for twenty years approximates to that of the general population. The low rate of cirrhosis in this group may be related to a low consumption of alcohol. Laparoscopic cholecystectomy is a safe procedure in patients with mild chronic liver disease caused by hepatitis C.
authors: Department of Academic Surgery, University College, Cork, Ireland.
authors: M J
authors: MJ
authors: O'Sullivan
authors: D
authors: D
authors: Evoy
authors: C
authors: C
authors: O'Donnell
authors: P K
authors: PK
authors: Rajpal
authors: B
authors: B
authors: Cannon
authors: L
authors: L
authors: Kenny-Walsh
authors: M J
authors: MJ
authors: Whelton
authors: H P
authors: HP
authors: Redmond
authors: W O
authors: WO
authors: Kirwan
mesh_terms: D017081:Cholecystectomy, Laparoscopic; D002769:Cholelithiasis / Q000453:epidemiology* / Q000601:surgery; D015331:Cohort Studies; D004340:Drug Contamination; D005260:Female; D019698:Hepatitis C, Chronic / Q000453:epidemiology* / Q000209:etiology; D006801:Humans; D015994:Incidence; D007518:Isoantibodies / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D018029:Rho(D) Immune Globulin; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D007518:Isoantibodies; C061961:RHO(D) antibody; D018029:Rho(D) Immune Globulin