title: Effects of inhalation of perfluorocarbon aerosol on oxygenation and pulmonary function compared to PGI2 inhalation in a sheep model of oleic acid-induced lung injury.
abstract: OBJECTIVE
  To evaluate the effects of PFC aerosol compared to PGI2 aerosol and NaCl aerosol on gas exchange and lung mechanics in oleic acid-induced acute lung injury.
  
  
  METHODS
  A prospective, controlled, randomised, in vivo animal laboratory study.
  
  
  METHODS
  Research laboratory at an university hospital.
  
  
  METHODS
  Twenty one (n = 21) adult sheep of either gender weighing 26.8+/-6.4 kg.
  
  
  METHODS
  The animals were randomised to three groups: PFC aerosol (perfluorooctane), PFC group; prostacyclin aerosol (Flolan), PGI2 group; and NaCl aerosol (0.9% sodium chloride solution), control group. After induction of anaesthesia and placement of vascular catheters, lung injury was induced with 0.12 ml x kg(-1) oleic acid. Aerosols were continuously administered for 2 h using a jet nebuliser. Gas exchange, pulmonary mechanic, and haemodynamic parameters were obtained at regular intervals.
  
  
  RESULTS
  PFC aerosol increased oxygenation (PaO2) 15 min after the initiation of treatment up to 120 min (P < 0.05). Transpulmonary shunt improved in the PFC group (P < 0.05) while it did not change in the two other groups. PFC aerosol reduced maximum airway pressure (Pmax) (median) significantly from (median) 38 mbar to 32 mbar (P < 0.05). Static compliance improved significantly in the PFC group (P < 0.05).
  
  
  CONCLUSIONS
  The inhalation of a PFC aerosol led to a significant improvement in pulmonary mechanics and gas exchange, which was not observed in the other two groups. These data suggest that a small dose of perfluorocarbon will have beneficial effects on gas exchange and respiratory mechanics. Therefore, the non-invasive aerosol application technique seems to be a reasonable alternative to administer perfluorocarbons in severe lung injury.
authors: Department of Anaesthesiology and Intensive Care Medicine, University Hospital Carl Gustav Carus, Medical Faculty, Technical University of Dresden, Germany. ragaller@rcs.urz.tu-dresden.de
authors: M
authors: M
authors: Ragaller
authors: J
authors: J
authors: Bleyl
authors: U
authors: U
authors: Tschö
authors: T
authors: T
authors: Winkler
authors: M
authors: M
authors: Regner
authors: S
authors: S
authors: Rasche
authors: T
authors: T
authors: Koch
authors: M
authors: M
authors: Albrecht
mesh_terms: D000336:Aerosols / Q000008:administration & dosage; D000818:Animals; D004195:Disease Models, Animal; D016503:Drug Delivery Systems; D011464:Epoprostenol / Q000008:administration & dosage*; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D019301:Oleic Acid; D011175:Positive-Pressure Respiration; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced / Q000503:physiopathology / Q000628:therapy*; D012756:Sheep
chemical_list: D000336:Aerosols; D005466:Fluorocarbons; D019301:Oleic Acid; C073608:perfluorooctane; D011464:Epoprostenol