title: Synthesis, physicochemical characterization, and cytotoxic screening of new zirconium complexes with coumarin derivatives.
abstract: Zirconium complexes of mendiaxon, warfarin, coumachlor, and niffcoumar have been synthesized by reaction of the ligands with zirconium chloride in stoichiometric ratio 1:2. The formation of the complexes has been proved on the basis of elemental analysis, IR-spectroscopy, 1H-NMR spectroscopy, and thermal studies. Differential thermal analyses and thermogravimetric analyses have been applied to study the compositions of the new complexes. It is concluded that the lactone- and the keto-carbonyl groups of warfarin, coumachlor, and niffcoumar are bonded to the metal ion as bidentate ligands, but mendiaxon is bonded as monodentate ligand. Cytotoxic screening by MTT-assay was carried out. Among these compounds the zirconium complex of mendiaxon showed highest cytotoxic activity against human promyelocytic leukemic HL-60 cells. The inorganic salt was found to be active against this cell line.
authors: Department of Chemistry, Faculty of Pharmacy, Medical University, 2 Dunav St., Sofia 1000, Bulgaria.
authors: I
authors: I
authors: Kostova
authors: I
authors: I
authors: Manolov
authors: M
authors: M
authors: Karaivanova
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003374:Coumarins / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D018922:HL-60 Cells / Q000187:drug effects; D006801:Humans; D006923:Hymecromone / Q000031:analogs & derivatives* / Q000494:pharmacology; D008024:Ligands; D009682:Magnetic Resonance Spectroscopy; D009942:Organometallic Compounds / Q000138:chemical synthesis; D013055:Spectrophotometry, Infrared; D014859:Warfarin / Q000031:analogs & derivatives / Q000494:pharmacology; D015040:Zirconium / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; D008024:Ligands; D009942:Organometallic Compounds; C432961:niffcoumar; D006923:Hymecromone; D014859:Warfarin; C030123:coumarin; D015040:Zirconium; C412550:coumachlor