title: Evaluation of hepatoprotective activity of legumes.
abstract: Mung bean, adzuki bean, black bean and rice bean are foods and folk medicines of Taiwan. We evaluated the effects of various water extract concentrations (100, 500 and 1000 mg/kg body wt.) and silymarin (25 mg/kg body wt. on acetaminophen-induced liver injury by measuring serum glutamate-oxalate-transaminase (sGOT) and serum glutamate-pyruvate-transaminase (sGPT) activities in rats. The results showed that the sGOT and the sGPT activities, increased by APAP, were decreased significantly (P < 0.05) through treatment with inceasing amounts up to 1000 mg/kg body wt. of the exracts. In particular, the mung bean aqueous extract showed the best hepatoprotective effect on APAP-induced hepatotoxicity. The pathological changes of liver injury caused by APAP improved by the treatment with all of the legume extracts, which were compared to silymarin as a standardized drug. In addition to these results, the extract of mung bean acted as a potential hepatoprotective agent in dietary supply.
authors: Department of Health and Nutrition, Chia-Nan University of Pharmacy and Science, Tainan, Taiwan, ROC.
authors: S J
authors: SJ
authors: Wu
authors: J S
authors: JS
authors: Wang
authors: C C
authors: CC
authors: Lin
authors: C H
authors: CH
authors: Chang
mesh_terms: D000082:Acetaminophen; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D004195:Disease Models, Animal; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D007887:Fabaceae / Q000737:chemistry*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D008516:Medicine, Chinese Traditional; D010946:Plants, Medicinal; D020011:Protective Agents / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012838:Silymarin / Q000494:pharmacology / Q000592:standards; D013624:Taiwan
chemical_list: D004365:Drugs, Chinese Herbal; D020011:Protective Agents; D012838:Silymarin; D000082:Acetaminophen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase