Cell density-correlated induction of pyruvate decarboxylase under aerobic conditions in the yeast Pichia stipitis.
During the aerobic batch cultivation of P. stipitis CBS 5776 with glucose, pyruvate decarboxylase was activated in a cell number-correlated manner. Activation started when a cell number between 7 x 10(7) and x 10(8) cells ml(-1) was reached and the enzyme activity increased during further cultivation. This induction might have been triggered either by an unknown quorum sensing system or by a shortage of cytoplasmic acetyl-CoA.
Mergler
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M
RWTH, Institut für Biologie IV, Lehr- und Forschungsgebiet Angewandte Mikrobiologie, Aachen, Germany.
Klinner
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D000332:Aerobiosis; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D010100:Oxygen / Q000494:pharmacology*; D010843:Pichia / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D011767:Pyruvate Decarboxylase / Q000096:biosynthesis*
D011767:Pyruvate Decarboxylase; D010100:Oxygen