Factor VIIIa-induced gene expression: potential implications in pathophysiology.
Binding of factor VIIa (VIIa) to tissue factor (TF) triggers the coagulation cascade. Several studies indicate a possible role for TF-VIIa in other cellular functions, in addition to coagulation, under pathophysiological conditions. Recent studies suggest that TF-VIIa mediates cell signaling by two distinct mechanisms, TF cytoplasmic domain-dependent and TF-VIIa protease activity-dependent. In this review, we focus upon TF-VIIa protease-induced gene expression and how the altered gene expression could potentially affect various cellular processes.
Rao
L V
LV
Biomedical Research Division, The University of Texas Health Center at Tyler, Tyler, TX 75708, USA. Vijay.Rao@uthct.edu
Pendurthi
U R
UR
D000818:Animals; D016228:Endothelial Growth Factors / Q000378:metabolism; D016326:Extracellular Matrix Proteins / Q000235:genetics; D015942:Factor VIIa / Q000235:genetics / Q000502:physiology*; D005347:Fibroblasts / Q000378:metabolism; D015870:Gene Expression / Q000502:physiology*; D006801:Humans; D008222:Lymphokines / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013925:Thromboplastin / Q000502:physiology*; D015854:Up-Regulation; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D016326:Extracellular Matrix Proteins; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D013925:Thromboplastin; D015942:Factor VIIa