Seizures in an interferon-treated child.
Interferon-treated patients can present seizures, which in most paediatric cases are related to fever. The case of chronic hepatitis C is described in which Interferon probably disclosed a latent epilepsy. The hypothesis is advanced that seizures can be provoked by Interferon therapy in subjects with a low convulsant threshold and, in those cases in which it cannot be substituted with another drug, antiepileptic therapy should be started after the first episode.
Valentini
P
P
Department of Paediatrics, Catholic University of the Sacred Heart, Rome, Italy. iclpe@rm.unicatt.it
Mariotti
P
P
Ngalikpima
C J
CJ
Angelone
D F
DF
Ranno
O
O
D000998:Antiviral Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced* / Q000175:diagnosis; D019698:Hepatitis C, Chronic / Q000188:drug therapy*; D006801:Humans; D016898:Interferon-alpha / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male
D000998:Antiviral Agents; D016898:Interferon-alpha