title: [Fibro-osseous lesion of the central nervous system].
abstract: The case of a 53-year-old woman with headache and progressive right sided decline of visual acuity is reported. Computed tomography scans of the brain revealed multiple circumscribed foci of mineralization located over the left frontal and parietal, as well as the right central brain parenchyma. Surgical sampling of the left frontal lesion yielded a conglomerate composed of mineralized vessels, myriad of psammoma bodies, and metaplastic lamellar bone entangled within poorly cellular collagen fibers. No evidence was found of an underlying vascular malformation or tumor, nor was there evidence of parenchymal necrosis of infectious origin. On account of the organoid association of the mesenchymal elements and the mineralized moiety, the lesion was consistent with fibro-osseous lesion of the central nervous system. Also known as "calcifying pseudotumor" of the brain, the origin of this exceedingly rare condition is, as yet, unknown. By analogy, its pathogenesis is likely to involve mechanisms underlying tumoral calcinosis of soft tissues.
authors: Szegedi Tudományegyetem, Szent-Györgyi Albert Orvos- és Gyógyszerésztudományi Centrum, Altalános Orvostudományi Kar, Pathologiai Intézet.
authors: G
authors: G
authors: Albu
authors: G
authors: G
authors: Deák
authors: Z
authors: Z
authors: Mencser
authors: I
authors: I
authors: Vajtai
mesh_terms: D001842:Bone and Bones; D001921:Brain / Q000473:pathology*; D001927:Brain Diseases / Q000150:complications / Q000175:diagnosis*; D002114:Calcinosis / Q000150:complications / Q000175:diagnosis*; D002828:Choristoma / Q000150:complications / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005355:Fibrosis / Q000150:complications / Q000175:diagnosis; D006261:Headache / Q000209:etiology; D006801:Humans; D008875:Middle Aged; D014786:Vision Disorders / Q000209:etiology