Severe hypertension and massive osteoporosis as presenting symptoms of Cushing's syndrome.
Though Cushing's syndrome is a well-known clinical problem in terms of side effects of steroid therapy, endogenous Cushing's syndrome is a relatively rare diagnosis. We treated a 27-year-old patient who presented with severe hypertension and massive osteoporosis. We could diagnose a central Cushing syndrome by endocrinological function tests which, in retrospect, existed undiagnosed for more than 5 years. However, magnetic resonance imaging did not display an adenoma neither of the hypophysis nor of the adrenal glands. During explorative surgery, a cylindric microadenoma of the pituary gland was found and excised. After surgery, the blood pressure returned to normal, making further antihypertensive treatment unnecessary.
Endemann
D H
DH
Klinik und Poliklinik für Innere Medizin I und II, Klinikum der Universität Regensburg, Deutschland. Dierk.Endemann@klinik.uni-regenburg.de
Fischereder
M
M
Leingärtner
T
T
Stubanus
M
M
Zietz
B
B
Riegger
G A
GA
Krämer
B K
BK
D000236:Adenoma / Q000150:complications* / Q000601:surgery; D000328:Adult; D003480:Cushing Syndrome / Q000175:diagnosis* / Q000209:etiology*; D006801:Humans; D006973:Hypertension / Q000150:complications*; D008297:Male; D010024:Osteoporosis / Q000150:complications*; D010902:Pituitary Gland / Q000601:surgery; D010911:Pituitary Neoplasms / Q000150:complications* / Q000601:surgery