title: Aldosteronoma in a dog with polyuria as the leading symptom.
abstract: In a 10-year-old castrated male shorthaired German pointer polyuria was associated with slight hypokalemia, hypophosphatemia and alkalosis, as well as elevated plasma concentrations of a glucocorticoid-inducible iso-enzyme of alkaline phosphatase. Repeated measurements of urinary corticoids and normal suppressibility of the hypothalamus-pituitary-adrenocorticial axis excluded glucocorticoid excess. Urine osmolality (Uosm) did not increase during administration of the vasopressin analogue desmopressin. At the time water deprivation had caused Uosm to rise from 300 to 788 mOsm/kg, there was also plasma hypertonicity. During hypertonic saline infusion the osmotic threshold for vasopressin release was increased. The combination of elevated plasma aldosterone concentrations and unmeasurably low plasma renin activity pointed to primary hyperaldosteronism. As initially computed tomography (CT) did not reveal an adrenocortical lesion, the dog was treated with the aldosterone antagonist spironolactone. This caused Uosm to rise in a dose-dependent manner. However, well-concentrated urine was only achieved with doses that gave rise to adverse effects. Once repeated CT, using 2-mm-thick slices, had revealed a small nodule in the cranial pole of the left adrenal, unilateral adrenalectomy was performed which resolved the polyuria completely. Also the plasma concentrations of kalium, aldosterone and renin activity returned to within their respective reference ranges. The adrenocortical nodule had the histological characteristics of an aldosteronoma, with the non-affected zona glomerulosa being atrophic.In this dog with primary hyperaldosteronism the polyuria was characterized by vasopressin resistance and increased osmotic threshold of vasopressin release, similar to the polyuria of glucocorticoid excess. The possibility is discussed that the polyuria of glucocorticoid excess is actually a mineralocorticoid effect.
authors: Department of Clinical Sciences of Companion Animals, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands. A.Rijnberk@vet.uu.nl
authors: A
authors: A
authors: Rijnberk
authors: H S
authors: HS
authors: Kooistra
authors: I K
authors: IK
authors: van Vonderen
authors: J A
authors: JA
authors: Mol
authors: G
authors: G
authors: Voorhout
authors: F J
authors: FJ
authors: van Sluijs
authors: J
authors: J
authors: IJzer
authors: T S
authors: TS
authors: van den Ingh
authors: P
authors: P
authors: Boer
authors: W H
authors: WH
authors: Boer
mesh_terms: D000315:Adrenalectomy; D000450:Aldosterone / Q000097:blood; D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000652:urine; D004285:Dogs; D006929:Hyperaldosteronism / Q000175:diagnosis / Q000601:surgery / Q000662:veterinary*; D008297:Male; D009994:Osmolar Concentration; D011141:Polyuria / Q000662:veterinary*; D012083:Renin / Q000097:blood; D012462:Saline Solution, Hypertonic; D014556:Urine; D014667:Vasopressins / Q000378:metabolism
chemical_list: D012462:Saline Solution, Hypertonic; D014667:Vasopressins; D000450:Aldosterone; D012083:Renin