title: A versatile palladium-mediated three-component reaction for the one-pot synthesis of stereodefined 3-arylidene-(or 3-alkenylidene-)tetrahydrofurans.
abstract: A one-pot reaction between equimolecular amounts of various propargyl alcohols, Michael acceptors, and unsaturated halides (or triflates) in the presence of a palladium(0) catalyst provides a simple and flexible entry into highly substituted 3-arylidene-(or 3-alkenylidene-)tetrahydrofurans. The efficiency of this palladium-mediated three-component reaction has been shown to be strongly influenced by the nature of the catalyst system, and in this regard, a palladium(0) catalyst generated in situ by reduction of PdCl2(PPh3)2 with n-butyllithium has been found particularly effective.
authors: Laboratoire de Chimie Organique 1, CNRS UMR 5622, Université Claude Bernard, Lyon I, CPE, 43 Bd du 11 Novembre 1918, 69622 Villeurbanne, France.
authors: M
authors: M
authors: Bottex
authors: M
authors: M
authors: Cavicchioli
authors: B
authors: B
authors: Hartmann
authors: N
authors: N
authors: Monteiro
authors: G
authors: G
authors: Balme