title: Serum soluble interleukin-2 receptor concentrations as an independent prognostic marker in head and neck cancer.
abstract: Currently head and neck squamous cell-carcinomas are staged clinically, though this is not ideal. We did a multivariate prospective study of 234 patients with head and neck squamous-cell carcinoma and showed that high serum concentrations of sIL-2Ralpha at diagnosis were highly correlated with a shorter survival (p<0.0001). In addition, patients who had low serum sIL-2Ralpha concentrations at diagnosis were less likely to develop distant metastasis during the 36 months follow up compared with the group with high serum sIL-2Ralpha concentrations (p<0.001). These findings suggest that serum sIL-2Ralpha could be considered as an independent serum biomarker in head and neck cancer patients.
authors: E
authors: E
authors: Tartour
authors: V
authors: V
authors: Mosseri
authors: T
authors: T
authors: Jouffroy
authors: L
authors: L
authors: Deneux
authors: C
authors: C
authors: Jaulerry
authors: F
authors: F
authors: Brunin
authors: W H
authors: WH
authors: Fridman
authors: J
authors: J
authors: Rodriguez
mesh_terms: D014408:Biomarkers, Tumor; D002294:Carcinoma, Squamous Cell / Q000097:blood* / Q000401:mortality; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000401:mortality; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D011379:Prognosis; D016016:Proportional Hazards Models; D011446:Prospective Studies; D015375:Receptors, Interleukin-2 / Q000097:blood*; D015996:Survival Rate
chemical_list: D014408:Biomarkers, Tumor; D015375:Receptors, Interleukin-2