Tritolylporphyrin dimer as a new potent hydrophobic sensitizer for photodynamic therapy of melanoma.
We report the synthesis, photochemical and photophysical properties and preliminary studies on biological effect of a new tritolylporphyrin dimer (T-D). Absorption and emission properties of T-D suggest its possible use in photodynamic therapy. T-D is capable of singlet oxygen production with 0.8 quantum yield. It also has a high photostability. The photodynamic properties of the dimer were examined following the growth of SKMEL 188 (human melanoma) cells irradiated with red light (cut off < 630 nm). The surviving fraction of the cells decreased about 3-fold (vs. non-irradiated cells) for an 81 J/cm dose. Our results suggest that tritolylporphyrine dimer T-D may be an interesting hydrophobic sensitizer for photodynamic therapy.
Drzewiecka
A
A
Faculty of Chemistry, Jagiellonian University, Kraków, Poland.
Urbańska
K
K
Matuszak
Z
Z
Pineiro
M
M
Arnaut
L G
LG
Habdas
J
J
Ratuszna
A
A
Stochel
G
G
D019281:Dimerization; D008545:Melanoma / Q000628:therapy*; D008956:Models, Chemical; D010100:Oxygen / Q000378:metabolism; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011166:Porphyrins / Q000138:chemical synthesis* / Q000737:chemistry* / Q000494:pharmacology*; D013053:Spectrophotometry; D013696:Temperature; D013997:Time Factors; D014466:Ultraviolet Rays
C439830:10,15,20-tritolylporphyrin-5-(4-amidophenyl)-(5-(4-phenyl)-10,15,20-tritolylporphyrin); D017319:Photosensitizing Agents; D011166:Porphyrins; D010100:Oxygen