[Zona pellucida antigens in the human ovum: its importance in contraceptive strategies].
The zona pellucida (ZP) is the extracellular matrix surrounding the mammalian oocyte. This matrix consists of three families called ZP1, ZP2 and ZP3. These proteins suffer several posttraductional modifications to give them different immunological and functional properties. In mice has been demonstrated the important role of ZP3 as a receptor of sperm. In the past, research in this field was limited for the difficulty to get enough biological material from different mammalian species, especially from human sources. Recently, several laboratories have expressed ZP recombinant proteins, allowing the study of the proteins under physiologic and pathophysiological conditions, giving the possibility to utilize ZP as a contraceptive target.
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Departamento de Biología de la Reproducción, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán.
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Méndez
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D000818:Animals; D004527:Egg Proteins / Q000502:physiology*; D005260:Female; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology*; D051379:Mice; D011956:Receptors, Cell Surface; D013045:Species Specificity; D013084:Sperm-Ovum Interactions / Q000502:physiology; D022642:Vaccines, Contraceptive / Q000276:immunology; D015044:Zona Pellucida / Q000502:physiology*; D000072216:Zona Pellucida Glycoproteins
D004527:Egg Proteins; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D022642:Vaccines, Contraceptive; C000606514:ZP1 protein, human; C000606515:ZP2 protein, human; C000606517:ZP3 protein, human; D000072216:Zona Pellucida Glycoproteins; C000606519:Zp1 protein, mouse; C000606520:Zp2 protein, mouse; C000606521:Zp3 protein, mouse