title: Formation of benzo[b]fluorenes and the benzo[a]fluorene core of the fluostatins by cyclization of diaryldiynones.
abstract: [figure: see text] Thermal cyclization of 1-[2-(trimethylsilylethynyl)phenyl]-3-arylpropinones was expected to give benzo[b]fluorenones. However, benzo[a]-fluorenones were also formed as a result of a new rearrangement. These tetracycles possess the core structure of the fluostatins and isoprekinamycin.
authors: Departamento de Química Orgánica, Universidad Autónoma de Madrid, Cantoblanco, 28049 Madrid, Spain.
authors: C
authors: C
authors: Atienza
authors: C
authors: C
authors: Mateo
authors: O
authors: O
authors: de Frutos
authors: A M
authors: AM
authors: Echavarren
mesh_terms: D000480:Alkynes / Q000138:chemical synthesis*; D005449:Fluorenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D007202:Indicators and Reagents; D008968:Molecular Conformation; D015394:Molecular Structure; D011500:Protein Synthesis Inhibitors / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
chemical_list: D000480:Alkynes; D005449:Fluorenes; D007202:Indicators and Reagents; D011500:Protein Synthesis Inhibitors; C041511:benzo(a)fluorene; C006703:benzo(b)fluoranthene