title: Angiotensin II alters blood flow distribution in amphibians.
abstract: In toads, angiotensin II (ANG II) induces the water absorption response (WR) during which the seat patch (pelvic+inner-thigh skin) is pressed to a wet substrate from which water flows osmotically into the animal. Since ANG II is a potent vasoconstrictor, it has the potential to redistribute blood flow. To determine the regional circulatory effects of ANG II, we used microsphere methods to measure relative changes in blood flow to several skin regions and other organs before and after ANG II administration in terrestrial toads and aquatic bullfrogs. In toads, after ANG II administration, seat patch and bladder blood flow increased by 264.2%+/-197.6% and 287.2%+/-86.7%, respectively (P<0.05), while dorsal and pectoral skin flow decreased by 48.0%+/-19.4% and 21.3%+/-25.4%, respectively (P<0.05). In bullfrogs, ANG II caused no significant changes in blood flow. Our results support our hypothesis that, in toads, ANG II increases and decreases blood flow to regions of the body associated with water gain and water loss, respectively.
authors: Department of Biology, New Mexico State University, Las Cruces, NM 88003, USA. slivkoff@u.arizona.edu
authors: M D
authors: MD
authors: Slivkoff
authors: S J
authors: SJ
authors: Warburton
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects / Q000502:physiology; D002025:Bufonidae / Q000502:physiology*; D003681:Dehydration; D010450:Endopeptidases / Q000008:administration & dosage / Q000494:pharmacology* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D008863:Microspheres; D011898:Ranidae / Q000502:physiology*; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D012867:Skin / Q000098:blood supply* / Q000187:drug effects; D018709:Statistics, Nonparametric; D001743:Urinary Bladder / Q000098:blood supply; D014870:Water Loss, Insensible / Q000187:drug effects
chemical_list: D010450:Endopeptidases; C047491:angiotensin-producing serum enzyme II