Fusion of two novel genes, RBM15 and MKL1, in the t(1;22)(p13;q13) of acute megakaryoblastic leukemia.
t(1;22) is the principal translocation of acute megakaryoblastic leukemias. Here we show this chromosomal rearrangement to result in the fusion of two novel genes, RNA-binding motif protein-15 (RBM15), an RNA recognition motif-encoding gene with homology to Drosophila spen, and Megakaryoblastic Leukemia-1 (MKL1), a gene encoding an SAP (SAF-A/B, Acinus and PIAS) DNA-binding domain.
Ma
Z
Z
Department of Pathology, St Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Morris
S W
SW
Valentine
V
V
Li
M
M
Herbrick
J A
JA
Cui
X
X
Bouman
D
D
Li
Y
Y
Mehta
P K
PK
Nizetic
D
D
Kaneko
Y
Y
Chan
G C
GC
Chan
L C
LC
Squire
J
J
Scherer
S W
SW
Hitzler
J K
JK
D002878:Chromosomes, Human, Pair 1 / Q000235:genetics; D002892:Chromosomes, Human, Pair 22 / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D006801:Humans; D007947:Leukemia, Megakaryoblastic, Acute / Q000235:genetics*; D008969:Molecular Sequence Data; D015514:Oncogene Proteins, Fusion / Q000235:genetics*; D016601:RNA-Binding Proteins / Q000235:genetics*; D015534:Trans-Activators; D014178:Translocation, Genetic
D004268:DNA-Binding Proteins; C431575:MRTFA protein, human; D015514:Oncogene Proteins, Fusion; C431574:RBM15 protein, human; D016601:RNA-Binding Proteins; D015534:Trans-Activators