Cardiac and intestinal amyloidosis in a renal transplant recipient with familial Mediterranean fever.
In Turkey, familial Mediterranean fever (FMF) is an important cause of nephrotic syndrome and endstage renal disease due to renal deposition of AA type amyloid. We report a case of living-related donor renal transplant recipient with FMF and renal AA type amyloidosis, who died of progressive heart failure due to cardiac involvement. The patient also had intractable diarrhea caused by biopsy-proven intestinal amyloidosis. The patient was on 1 mg/day colchicine. Although he was attack-free throughout the post-transplant period, intestinal and clinically significant cardiac amyloidosis, which implied the presence of sustained inflammation and continuing amyloid deposition, appeared three years after renal transplantation. Cardiac deposition of AA amyloid may cause clinically significant heart disease, leading to cardiovascular mortality after renal transplantation for end-stage renal disease in FMF patients.
Yildiz
A
A
Department of Internal Medicine and Division of Nephrology, University of Istanbul, Istanbul Faculty of Medicine, Istanbul, Turkey. alaattiny@hotmail.com
Akkaya
V
V
Kiliçaslan
I
I
Türkmen
A
A
Görçin
B
B
Atilgan
D
D
Sever
M S
MS
D000328:Adult; D000686:Amyloidosis / Q000175:diagnosis / Q000473:pathology*; D001707:Biopsy, Needle; D010505:Familial Mediterranean Fever / Q000150:complications* / Q000175:diagnosis; D017809:Fatal Outcome; D006333:Heart Failure / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007410:Intestinal Diseases / Q000175:diagnosis / Q000473:pathology*; D016030:Kidney Transplantation; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D012720:Severity of Illness Index; D014421:Turkey