The effect on the hemodynamic stability of varying calcium chloride administration during protamine infusion in pediatric open-heart patients.
We conducted a randomized study in 147 pediatric patients undergoing cardiopulmonary bypass to determine when there are any differences in hemodynamic effects if CaCl(2) 20 mg/kg and protamine 5mg/kg are mixed together and infused over 10 min versus administering half of the calcium dose (10 mg/kg) as a bolus followed by a 10-min infusion of protamine 5 mg/kg and CaCl(2) 10mg/kg.
Muangmingsuk
V
V
Department of Anesthesia, The Heart Institute for Children, Advocate Christ Hospital and Medical Center, Oak Lawn, IL 60453, USA.
Tremback
T F
TF
Muangmingsuk
S
S
Roberson
D A
DA
Cipparrone
N E
NE
D000293:Adolescent; D000768:Anesthesia, General; D001831:Body Temperature / Q000187:drug effects; D002122:Calcium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D006348:Cardiac Surgical Procedures; D002648:Child; D002675:Child, Preschool; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects*; D006494:Heparin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007262:Infusions, Intravenous; D008297:Male; D010100:Oxygen / Q000097:blood; D011479:Protamines / Q000008:administration & dosage / Q000494:pharmacology*; D016277:Ventricular Function, Left
D006494:Heparin Antagonists; D011479:Protamines; D002122:Calcium Chloride; D010100:Oxygen