Spongiadioxins A and B, two new polybrominated dibenzo-p-dioxins from an Australian marine sponge Dysidea dendyi.
Two new cytotoxic tetrabromodibenzo-p-dioxins, spongiadioxins A (1) and B (2), were isolated from an Australian marine sponge Dysidea dendyi. The structures of these compounds were established by 1D and 2D NMR spectroscopy, X-ray analysis of the methyl ether of spongiadioxin A (3), and synthesis of the methyl ether of spongiadioxin B (4) from diphenyl ether (9) isolated from Dysidea herbacea.
Utkina
N K
NK
Pacific Institute of Bioorganic Chemistry, Russian Academy of Sciences, 690022 Vladivostok, Russia. utkinan@mail.ru
Denisenko
V A
VA
Scholokova
O V
OV
Virovaya
M V
MV
Gerasimenko
A V
AV
Popov
D Y
DY
Krasokhin
V B
VB
Popov
A M
AM
D000818:Animals; D001315:Australia; D004147:Dioxins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D008958:Models, Molecular; D011161:Porifera / Q000737:chemistry*
D004147:Dioxins; C433568:spongiadioxin A; C433569:spongiadioxin B