IGF-I, IGFBP-2 and -3 but not GH concentrations are different in normal and poor growing piglets.
In this study we investigated the somatotropic axis in piglets with evident growth delay. Female Suffolk crossbred piglets (30 days old; N = 12) were divided into normal weight (10 +/- 0.9 kg) and poor growing subjects (7 +/- 0.5 kg) and bled for growth hormone (GH), Insulin-like growth factor-I (IGF-I), Insulin-like growth factor binding protein 2 and 3 (IGFBP-2 and -3) determination. Basal and induced-GH levels were not different in the groups. Plasma IGF-I concentrations were significantly different (p < 0.001): 101.8 +/- 9.8 ng x mL(-1) (normal weight group) and 39.5 +/- 4.0 ng x mL(-1) (poor growing group). IGFBP-2 and -3 concentrations were significantly (p < 0.001) lower in poor growing than in normal piglets. Piglet weight was positively correlated (r = 0.98, p < 0.001) with IGF-I and IGFBP-2 or -3 concentrations. Our data indicate that growth rate was not correlated to basal or secretagogue-induced GH secretion.
Saleri
R
R
Istituto di Fisiologia Veterinaria, Università di Parma, Italy.
Baratta
M
M
Mainardi
G L
GL
Renaville
R
R
Giustina
A
A
Quintavalla
F
F
Tamanini
C
C
D000818:Animals; D001835:Body Weight; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000503:physiopathology / Q000662:veterinary; D013006:Growth Hormone / Q000032:analysis / Q000097:blood*; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000032:analysis / Q000097:blood*; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000032:analysis / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D013552:Swine / Q000097:blood / Q000254:growth & development*; D013553:Swine Diseases / Q000097:blood / Q000503:physiopathology
D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone