Cytotoxic constituents of Psoralea corylifolia.
A coumestan derivative, psoralidin (1) was found to be a cytotoxic principle of the seeds of Psoralea corylifolia L. (Leguminosae) with the IC50 values of 0.3 and 0.4 microg/ml against the HT-29 (colon) and MCF-7 (breast) human cancer cell lines, respectively. A coumarin, angelicin (2) was also isolated as a marginally cytotoxic agent along with an inactive compound, psoralen (3) from the plant. The isolates 1-3 were not active against the A541 (lung) and HepG2 (liver hepatoma) cancer cell lines.
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Natural Products Research Institute, Seoul National University, Korea.
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D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000302:isolation & purification; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D011564:Furocoumarins / Q000737:chemistry / Q000302:isolation & purification; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D029907:Psoralea / Q000737:chemistry*; D051381:Rats; D012639:Seeds / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D001572:Benzofurans; D003374:Coumarins; D011564:Furocoumarins; D007202:Indicators and Reagents; C011659:angelicin; C102768:psoralidin