Resveratrol, a tumor-suppressive compound from grapes, induces apoptosis via a novel mitochondrial pathway controlled by Bcl-2.
Tinhofer
I
I
Laboratory of Molecular Cytology, Department of Internal Medicine, University of Innsbruck, A-6020 Innsbruck, Austria.
Bernhard
D
D
Senfter
M
M
Anether
G
G
Loeffler
M
M
Kroemer
G
G
Kofler
R
R
Csordas
A
A
Greil
R
R
D016588:Anticarcinogenic Agents / Q000494:pharmacology; D017209:Apoptosis; D051033:Apoptosis Inducing Factor; D001692:Biological Transport / Q000187:drug effects; D053143:Caspase 2; D053148:Caspase 3; D053178:Caspase 6; D053453:Caspase 9; D020169:Caspases / Q000378:metabolism; D003574:Cytochrome c Group / Q000378:metabolism; D004247:DNA / Q000187:drug effects / Q000378:metabolism; D004789:Enzyme Activation; D005420:Flavoproteins / Q000378:metabolism; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism; D018124:Receptors, Tumor Necrosis Factor; D053219:Receptors, Tumor Necrosis Factor, Member 25; D000077185:Resveratrol; D019685:Rosales / Q000737:chemistry; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology; D013267:Stilbenes / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D016588:Anticarcinogenic Agents; D051033:Apoptosis Inducing Factor; D003574:Cytochrome c Group; D005420:Flavoproteins; D008565:Membrane Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D017382:Reactive Oxygen Species; D018124:Receptors, Tumor Necrosis Factor; D053219:Receptors, Tumor Necrosis Factor, Member 25; D013267:Stilbenes; C506033:TNFRSF25 protein, human; D004247:DNA; C505407:CASP3 protein, human; C505514:CASP6 protein, human; C506433:CASP9 protein, human; D053143:Caspase 2; D053148:Caspase 3; D053178:Caspase 6; D053453:Caspase 9; D020169:Caspases; D000077185:Resveratrol