Fatal late coronary thrombosis after implantation of a radioactive stent: postmortem angiographic and histologic findings--case report.
Postmortem angiography and histologic analysis of a fatal coronary thrombosis 4 months after implantation of a radioactive stent are described. Histologic findings suggested incomplete re-endothelialization in the segment with the stent. Ionizing radiation may delay re-endothelialization after revascularization, thus maintaining the thrombogenicity of the irradiated vessel segment. Thus, prolonged antiplatelet therapy should be considered after intravascular radiation therapy.
Wexberg
P
P
Department of Cardiology, Clinic for Internal Medicine II, University of Vienna, Währinger Gürtel 18-20, A-1090 Vienna, Austria. paul.wexberg@akh-wien.ac.at
Gottsauner-Wolf
M
M
Sulzbacher
I
I
Birner
P
P
Laggner
A
A
Glogar
D
D
D000368:Aged; D001344:Autopsy; D001707:Biopsy, Needle; D006328:Cardiac Catheterization / Q000295:instrumentation / Q000379:methods; D017023:Coronary Angiography / Q000379:methods*; D003331:Coronary Vessels / Q000473:pathology*; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000628:therapy*; D010761:Phosphorus Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D011868:Radioisotopes; D012008:Recurrence; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D015607:Stents / Q000009:adverse effects*
D010761:Phosphorus Radioisotopes; D011868:Radioisotopes