In vitro effects of photodynamic therapy on Aspergillus fumigatus.
Photodynamic therapy is a technique for killing cells with visible light after pretreatment with a photosensitizing agent. We demonstrated significant in vitro fungicidal activity against Aspergillus fumigatus of the photosensitizer Green 2W, activated with 630 nm light. This effect was both inoculum- and light dose-dependent. At a Green 2W concentration of 31.5 mg/L, there was complete killing of 2.7 x 10(1) cfu/mL with a light dose of 110 J/cm(2) and up to 2.7 x 10(6) cfu/mL with a light dose of 385 J/cm(2).
Friedberg
J S
JS
Department of Surgery, School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA. joseph.friedberg@mail.TJU.edu
Skema
C
C
Baum
E D
ED
Burdick
J
J
Vinogradov
S A
SA
Wilson
D F
DF
Horan
A D
AD
Nachamkin
I
I
D001232:Aspergillus fumigatus / Q000187:drug effects*; D010778:Photochemotherapy