Novel sulfonate derivatives: potent antimitotic agents.
The synthesis and biological evaluation of novel sulfonate analogues of E-7010 are reported. Several of the compounds are potent inhibitors of cell proliferation and tubulin polymerization. Importantly, these compounds are also active against P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents.
Gwaltney
S L
SL
Cancer Research, D47B, Building AP-10, Abbott Laboratories, 60064-6101, Abbott Park, IL, USA
Imade
H M
HM
Li
Q
Q
Gehrke
L
L
Credo
R B
RB
Warner
R B
RB
Lee
J Y
JY
Kovar
P
P
Frost
D
D
Ng
S C
SC
Sham
H L
HL
D000627:Aminophenols / Q000737:chemistry*; D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008938:Mitosis / Q000187:drug effects*; D013449:Sulfonamides / Q000737:chemistry*; D013451:Sulfonic Acids / Q000737:chemistry / Q000494:pharmacology*; D014407:Tumor Cells, Cultured; D000096926:Benzenesulfonamides
D000627:Aminophenols; D000970:Antineoplastic Agents; D013449:Sulfonamides; D013451:Sulfonic Acids; C079199:E 7010; D000096926:Benzenesulfonamides