title: The absence of interictal spikes with documented seizures suggests extratemporal epilepsy.
abstract: OBJECTIVE
  To determine the demographic and clinical characteristics of patients who have documented epileptic seizures on long-term video-EEG monitoring who do not have interictal spikes.
  
  
  METHODS
  The records of 1,223 monitoring studies from 919 patients who underwent noninvasive long-term video-EEG monitoring were reviewed. In 28 patients (3.0% of monitored patients, 4.4% of patients with electrographic evidence of epilepsy), no interictal spikes were found despite the occurrence of at least one recorded electrographic seizure. The demographic, medical, neuropsychological, and EEG data of these patients were compared with those of 28 matched control patients with documented interictal spikes.
  
  
  RESULTS
  Extratemporal seizures were significantly more frequent in the patients with at least one recorded epileptic seizure but without interictal spikes compared with patients with epileptic seizures and interictal spikes (p = 0.031). The only other significant difference between the groups (p = 0.016) was a later age at seizure onset (18.3 vs. 10.7 years) for the patients without interictal spikes. Age at evaluation, gender, handedness, clinical seizure type, family history of epilepsy, history of febrile seizures, neuropsychological testing, and neurologic and psychiatric history did not differ between the two groups.
  
  
  CONCLUSIONS
  In patients with documented epilepsy without interictal spikes on EEG monitoring, the possibility of an extratemporal focus should be considered.
authors: Regional Epilepsy Center, University of Washington, Harborview Medical Center, 325 9th Ave., Seattle, WA 98104-2499, U.S.A.
authors: O
authors: O
authors: Stüve
authors: C B
authors: CB
authors: Dodrill
authors: M D
authors: MD
authors: Holmes
authors: J W
authors: JW
authors: Miller
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D002648:Child; D015897:Comorbidity; D004569:Electroencephalography / Q000706:statistics & numerical data*; D004827:Epilepsy / Q000175:diagnosis* / Q000453:epidemiology; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis; D005190:Family; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000706:statistics & numerical data; D009460:Neurologic Examination; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D012189:Retrospective Studies; D012640:Seizures / Q000175:diagnosis* / Q000453:epidemiology; D003294:Seizures, Febrile / Q000175:diagnosis / Q000453:epidemiology; D014743:Videotape Recording