Use of ambulatory blood pressure monitoring data to predict left ventricular mass in hypertension.
BACKGROUND
Many studies have shown definite but weak correlations between 24h blood pressure and left ventricular mass in hypertension.


OBJECTIVE
The present study applied an original multivariate analysis of parameters from ambulatory blood pressure monitoring to predict left ventricular mass in hypertension.


METHODS
Two hundred untreated hypertensive subjects (age=51+/-13 years, clinic blood pressure=163/98mmHg) had echocardiography and 24h recording of blood pressure. Data from 102 subjects were used to construct a mathematical model for prediction of left ventricular mass. The remaining 98 subjects were used to validate the model.


RESULTS
The model included age, weight, height, 24h systolic blood pressure, heart rate over 24h, standard deviations of systolic blood pressure and of heart rate over 24h. Using this model, we explained 63% of the variance of left ventricular mass. Moreover, the model was validated for the correlation (r=0.70) between measured and the estimated left ventricular mass.


CONCLUSIONS
Systolic blood pressure, heart rate and their standard deviations over 24h contribute to left ventricular mass in hypertensive subjects. Thus, it is important to take into account not only blood pressure but also heart rate in clinical studies.
Baguet
J P
JP
Department of Internal Medicine and Cardiology, Grenoble University Hospital, Grenoble, France. JPBaguet@chu-grenoble.fr
De Gaudemaris
R
R
Antoniadis
A
A
Tremel
F
F
Siché
J P
JP
Mallion
J M
JM
D000328:Adult; D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory / Q000379:methods*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D006973:Hypertension / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology*; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests