Robustness as an evolutionary principle.
We suggest simulating evolution of complex organisms using a model constrained solely by the requirement of robustness in its expression patterns. This scenario is illustrated by evolving discrete logical networks with epigenetic properties. Evidence for dynamical features in the evolved networks is found that can be related to biological observables.
Bornholdt
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Institut für Theoretische Physik, Universität Kiel, Leibnizstrasse 15, D-24098 Kiel, Germany. bornhol@theo-physik.uni-kiel.de
Sneppen
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D000818:Animals; D005075:Biological Evolution; D004843:Epistasis, Genetic; D005786:Gene Expression Regulation; D008957:Models, Genetic; D008962:Models, Theoretical