Genetical genomics: the added value from segregation.
The recent successes of genome-wide expression profiling in biology tend to overlook the power of genetics. We here propose a merger of genomics and genetics into 'genetical genomics'. This involves expression profiling and marker-based fingerprinting of each individual of a segregating population, and exploits all the statistical tools used in the analysis of quantitative trait loci. Genetical genomics will combine the power of two different worlds in a way that is likely to become instrumental in the further unravelling of metabolic, regulatory and developmental pathways.
Jansen
R C
RC
Plant Research International BV, PO Box 16, NL-6700 AA, Wageningen, The Netherlands. r.c.jansen@plant.wag-ur.nl
Nap
J P
JP
D000818:Animals; D002874:Chromosome Mapping / Q000379:methods*; D020090:Chromosome Segregation / Q000235:genetics; D016172:DNA Fingerprinting / Q000379:methods; D018076:DNA, Complementary / Q000235:genetics; D020869:Gene Expression Profiling / Q000379:methods*; D014644:Genetic Variation / Q000235:genetics; D015894:Genome, Human; D023281:Genomics / Q000379:methods*; D006801:Humans; D020411:Oligonucleotide Array Sequence Analysis; D010944:Plants / Q000235:genetics; D019655:Quantitative Trait, Heritable
D018076:DNA, Complementary