Bio-inspired synthetic receptor molecules towards mimicry of vancomycin.
A 512-member library of bio-inspired synthetic receptor molecules was prepared featuring a triazacyclophane scaffold. The purpose of this scaffold was to orient three (identical) peptide 'binding arms' in order to mimic an antibiotic binding cavity as is present in the vancomycin antibiotics. The library was screened with D-Ala-D-Ala and D-Ala-D-Lac containing ligands, which are present in the cell wall precursors of pathogenic bacteria. Screening and validation led to identification of a synthetic receptor capable of binding these ligands.
Monnee
M C
MC
Department of Medicinal Chemistry, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, PO Box 80082, 3508 TB Utrecht, The Netherlands.
Brouwer
A J
AJ
Verbeek
L M
LM
van Wageningen
A M
AM
Liskamp
R M
RM
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000378:metabolism; D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques; D008024:Ligands; D018716:Molecular Mimicry; D009842:Oligopeptides / Q000138:chemical synthesis / Q000378:metabolism; D014640:Vancomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D008024:Ligands; D009842:Oligopeptides; D014640:Vancomycin