Interleukin levels in cerebrospinal fluid from children with neurocysticercosis.
No information about the levels of pro-inflammatory interleukins has been described in children with neurocysticercosis (NCC). The levels of tumor necrosis factor-alpha (TNF-alpha), interleukin (IL)-5, IL-6, and IL-12 in the cerebrospinal fluid from children with NCC were determined by enzyme-linked immunosorbent assay (ELISA). Twelve children with NCC, six with active and six with inactive disease, and six children without NCC were studied. TNF-alpha was undetectable in CSF from controls and five children with inactive NCC, whereas the levels were significantly higher (median 22.1 pg/ml; P = 0.008) in all children with active NCC. Levels of IL-6 were low in active and inactive NCC patients but two subjects with active subarachnoid disease had high levels. IL-5 and IL-12 were not detected. This study shows that high levels of TNF-alpha are present in CSF from children with active NCC. IL-6 levels are higher when infection occurs in the subarachnoid space.
Aguilar-Rebolledo
F
F
Departamento de Neurología, Hospital de Pediatría, CMN Siglo XXI, IMSS, Mexico DF, México.
Cedillo-Rivera
R
R
Llaguno-Violante
P
P
Torres-López
J
J
Muñoz-Hernandez
O
O
Enciso-Moreno
J A
JA
D000293:Adolescent; D015153:Blotting, Western; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007378:Interleukins / Q000134:cerebrospinal fluid*; D008279:Magnetic Resonance Imaging; D008297:Male; D008800:Mexico; D020019:Neurocysticercosis / Q000276:immunology* / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid*
D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha