Increase of isoprostane 8-epi-PGF(2alpha)after restarting smoking.
Isoprostanes are known as reliable markers of in vivo oxidation injury. Cigarette smoking has been shown to be associated with a significant increase in 8-epi-PGF(2alpha), a major member of this family of compounds. Quitting smoking reduces 8-epi-PGF(2alpha) values to normal within a couple of weeks only. In this follow-up we checked the 8-epi-PGF(2alpha), values in plasma, serum and urine in 28 people who restarted smoking after a quitting attempt of various duration. 8-epi-PGF(2alpha)shows a certain increase after restarting smoking reaching a maximum after already 1 week. Continuation of smoking does not significantly further increase 8-epi-PGF(2alpha). These data indicate a fast response of restarting as on quitting smoking on in vivo oxidation injury. The oxidation injury reflected by 8-epi-PGF(2alpha)may be a key pathogenetic mechanism in smoking-induced vascular injury.
Chehne
F
F
Department of Nuclear Medicine, University of Vienna, A-1090 Vienna, Austria.
Oguogho
A
A
Lupattelli
G
G
Budinsky
A C
AC
Palumbo
B
B
Sinzinger
H
H
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood / Q000652:urine; D015415:Biomarkers / Q000097:blood / Q000652:urine; D015237:Dinoprost / Q000031:analogs & derivatives*; D028441:F2-Isoprostanes / Q000097:blood* / Q000652:urine*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood / Q000652:urine; D006973:Hypertension / Q000097:blood / Q000652:urine; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D012907:Smoking / Q000009:adverse effects* / Q000097:blood / Q000652:urine; D016540:Smoking Cessation; D013997:Time Factors
D015415:Biomarkers; D028441:F2-Isoprostanes; C075750:8-epi-prostaglandin F2alpha; D015237:Dinoprost