title: Neural recognition molecule NB-2 of the contactin/F3 subgroup in rat: Specificity in neurite outgrowth-promoting activity and restricted expression in the brain regions.
abstract: NB-2, a neural cell recognition molecule of the contactin/F3 subgroup, promoted neurite outgrowth of the cerebral cortical neurons but not the hippocampal neurons. NB-2 in rat became apparent after birth at protein level, reaching a maximum at postnatal day 14 in the cerebrum and postnatal day 3 in the cerebellum. NB-2 in the cerebellum declined abruptly thereafter. In situ hybridization demonstrated that NB-2 mRNA was highly expressed in regions implicated in the central auditory pathway, including the cochlear nuclei, superior olive, inferior colliculi, medial geniculate nuclei, and auditory cortex. In addition, a high level of NB-2 expression was observed in the accessory olfactory bulb, thalamic nuclei, facial nucleus, and inferior olive. By immunohistochemistry, intense immunoreactivity against NB-2 was also detected in the auditory pathway. Thus, NB-2 is expressed in highly restricted brain regions, including the auditory system, suggesting that it plays specific roles in the development and/or maturation of the regions.
authors: Department of Cell Recognition, Tokyo Metropolitan Institute of Gerontology, Itabashi-ku, Tokyo, Japan.
authors: J
authors: J
authors: Ogawa
authors: S
authors: S
authors: Lee
authors: K
authors: K
authors: Itoh
authors: S
authors: S
authors: Nagata
authors: T
authors: T
authors: Machida
authors: Y
authors: Y
authors: Takeda
authors: K
authors: K
authors: Watanabe
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000166:cytology / Q000196:embryology* / Q000254:growth & development*; D015816:Cell Adhesion Molecules, Neuronal / Q000235:genetics / Q000378:metabolism* / Q000494:pharmacology; D002450:Cell Communication / Q000502:physiology; D002454:Cell Differentiation / Q000187:drug effects / Q000502:physiology*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D058966:Contactins; D000939:Epitopes / Q000378:metabolism; D005333:Fetus; D018507:Gene Expression Regulation, Developmental / Q000187:drug effects / Q000502:physiology*; D007150:Immunohistochemistry; D016501:Neurites / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D010738:Type C Phospholipases / Q000494:pharmacology
chemical_list: D015816:Cell Adhesion Molecules, Neuronal; C104187:Cntn5 protein, rat; D058966:Contactins; D000939:Epitopes; D012333:RNA, Messenger; D010738:Type C Phospholipases; D043265:Phosphatidylinositol Diacylglycerol-Lyase