title: Efficacy of 7-day treatment with metronidazole+miconazole (Neo-Penotran) - a triple-active pessary for the treatment of single and mixed vaginal infections.
abstract: OBJECTIVE
  To evaluate the efficacy of Neo-Penotran pessaries (metronidazole 500 mg + miconazole nitrate 100 mg) in candidal, bacterial and trichomonal vaginitis and in mixed vaginal infections.
  
  
  METHODS
  Ninety-seven patients with clinical diagnosis of vaginitis entered this open, non-comparative study. Each patient inserted one pessary twice daily for 7 days. Gynecological and microbiological assessments were carried out before, and 8-10/21-23 days after the start of treatment.
  
  
  RESULTS
  Vaginitis symptoms were resolved in 91% of the 74 patients evaluated, and improved in a further 7%. Microbiological cure rates were 97.3% for trichomonal, 86.6% for bacterial and 81% for candidal vaginitis. Recurrence rates were 2.7, 3.8 and 16.1%, respectively. Overall microbiological cure rate for mixed infections was 86%, with 93% for trichomonal+bacterial, and 73% for bacterial+candidal vaginitis. In two out of three cases with trichomonal+bacterial+candidal infection, the microorganisms were eradicated completely.
  
  
  CONCLUSIONS
  Neo-Penotran provides immediate and effective treatment for vaginitis, irrespective of single or multiple infection, even when the diagnosis may be uncertain.
authors: Onur Medical Research Ltd., Istanbul, Turkey.
authors: E
authors: E
authors: Ozyurt
authors: M B
authors: MB
authors: Toykuliyeva
authors: I L
authors: IL
authors: Danilyans
authors: O
authors: O
authors: Morton
authors: G
authors: G
authors: Baktir
mesh_terms: D000282:Administration, Intravaginal; D000293:Adolescent; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage*; D000994:Antitrichomonal Agents / Q000008:administration & dosage*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000008:administration & dosage*; D008825:Miconazole / Q000008:administration & dosage*; D008875:Middle Aged; D016896:Treatment Outcome; D014247:Trichomonas Vaginitis / Q000188:drug therapy; D014627:Vaginitis / Q000188:drug therapy*; D016585:Vaginosis, Bacterial / Q000188:drug therapy
chemical_list: D000935:Antifungal Agents; D000994:Antitrichomonal Agents; D008795:Metronidazole; D008825:Miconazole