[Hypoxic encephalopathy and cortical laminar necrosis].
BACKGROUND
Cortical laminar necrosis is characterized by destruction of the cerebral cortex, mainly of the third layer, in situations of reduced energy supply to the brain. The cerebral lesions caused are known through studies made at autopsies, but there are few descriptions in the literature of the neuroimaging changes. We report the case of a patient who suffered hypoxic encephalopathy secondary to prolonged status epilepticus, and in whom cerebral MR showed changes compatible with cortical laminar necrosis.


METHODS
A 16 year old girl who had been epileptic since infancy presented with a state of generalized tonic-clonic convulsions followed by coma. Three weeks later she was mute, had a blink reflect to threats and followed visual stimuli with eye movements but no voluntary motor or verbal response. She also showed generalized hypertonia and fine tremor of her arms, which she moved spontaneously with no asymmetry. After two months her clinical condition became stable. Cerebral MR at this time showed diffuse hypersignal of the cortex and basal ganglia in T2 and FLAIR sequences and hyposignal of the subcortical white matter associated with a marked hypersignal delimiting the grooves of convexity in T1 sequences.


CONCLUSIONS
Situations of prolonged hypoxia, such as in status epilepticus, lead to necrosis of layers of the cerebral cortex. Clinically this is seen as the appearance of hypoxic encephalopathy and radiologically as characteristic alterations of neuroimaging known as cortical laminar necrosis.
Serrano
M
M
Servicio de Neurología; Hospital Miguel Servet, Zaragoza, 50009, España. germanger@teleline.es
Ara
J R
JR
Fayed
N
N
Alarcia
R
R
Latorre
A
A
D001479:Basal Ganglia / Q000473:pathology; D005260:Female; D006801:Humans; D007031:Hypothalamus / Q000473:pathology*; D002534:Hypoxia, Brain / Q000150:complications* / Q000209:etiology / Q000473:pathology*; D008279:Magnetic Resonance Imaging; D009336:Necrosis; D013226:Status Epilepticus / Q000150:complications