title: Polyamine uptake systems in Escherichia coli.
abstract: The polyamine content of cells is regulated by biosynthesis, degradation, and transport. In Escherichia coli, the genes for three different polyamine transport systems have been cloned and characterized. Two uptake systems (putrescine-specific and spermidine-preferential) are ABC transporters, each consisting of a periplasmic substrate binding protein, two transmembrane proteins, and a membrane-associated ATPase. The third transport system, catalyzed by PotE, mediates both uptake and excretion of putrescine. In this article, the properties of the first two polyamine uptake systems are reviewed in detail.
authors: Graduate School of Pharmaceutical Sciences, Chiba University, Japan. iga16077@p.chiba-u.ac.jp
authors: K
authors: K
authors: Igarashi
authors: K
authors: K
authors: Ito
authors: K
authors: K
authors: Kashiwagi
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000595:Amino Acid Sequence; D017920:Antiporters / Q000378:metabolism; D001426:Bacterial Proteins / Q000378:metabolism; D001692:Biological Transport; D004926:Escherichia coli / Q000378:metabolism*; D029968:Escherichia coli Proteins / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D008969:Molecular Sequence Data; D033902:Periplasmic Binding Proteins; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D016415:Sequence Alignment; D013095:Spermidine / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D017920:Antiporters; D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D033902:Periplasmic Binding Proteins; D011073:Polyamines; C099274:PotD protein, E coli; C071519:PotE protein, E coli; D013095:Spermidine; D011700:Putrescine