title: Pathogenesis of influenza A (H5N1) virus infection in a primate model.
abstract: Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.
authors: Institute of Virology, National Influenza Center, Erasmus University Medical Center Rotterdam, 3000 DR Rotterdam, The Netherlands.
authors: G F
authors: GF
authors: Rimmelzwaan
authors: T
authors: T
authors: Kuiken
authors: G
authors: G
authors: van Amerongen
authors: T M
authors: TM
authors: Bestebroer
authors: R A
authors: RA
authors: Fouchier
authors: A D
authors: AD
authors: Osterhaus
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005334:Fever / Q000473:pathology; D007150:Immunohistochemistry; D053124:Influenza A Virus, H5N1 Subtype; D009980:Influenza A virus / Q000302:isolation & purification; D017563:Lung Diseases, Interstitial / Q000473:pathology / Q000821:virology; D008252:Macaca fascicularis; D009336:Necrosis; D009976:Orthomyxoviridae Infections / Q000821:virology*; D012128:Respiratory Distress Syndrome / Q000473:pathology; D014781:Viscera / Q000821:virology