[The role of calcium-dependent mechanism in the realization of immune effects of kidney peptide complex].
The role of intracellular and extracellular calcium in the realization of immune effects of the kidney peptide complex were studied. Expression of surface immunoglobulin receptors on lymphocytes depressed under the influence of calcium channels blockators (verapamil, phenigidin), binding of intracellular and extracellular calcium (EDTA, BAPTA). The kidney peptide complex restorted expression of surface immunoglobulins depressed by verapamil, phenigidin, EDTA, BAPTA. Also in this conditions the peptide complex increased the re-assembly of receptors, as caps, patches and clasters. Kidney peptide complex has a synergy with the calcium ionophor A 23187 to increase the expression of surface immunoglobulin receptor on lymphocytes. We could not exclude the direct influence of peptide complex on the conformation changes of the ion traffic systems for calcium. It was suggested that peptide complex promote the entrance of calcium ions into the cells. The influence of kidney peptide complex on expression of lymphocytes membrane receptors are independent from the calcium existence neither into cells nor outside the cells.
Vesnina
L E
LE
Ukrainian Medical Stomatological Academy, Ministry of Health Public Service of Ukraine, Poltava.
Kaĭdashev
I P
IP
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000001:Calcimycin / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000378:metabolism; D015220:Calcium Channels / Q000378:metabolism*; D004357:Drug Synergism; D006801:Humans; D007136:Immunoglobulins / Q000187:drug effects*; D017136:Ion Transport / Q000187:drug effects*; D007668:Kidney / Q000378:metabolism*; D014700:Verapamil / Q000378:metabolism
D000900:Anti-Bacterial Agents; D002121:Calcium Channel Blockers; D015220:Calcium Channels; D007136:Immunoglobulins; D000001:Calcimycin; D014700:Verapamil