Three new peroxides from the sponge Plakinastrella species.
Two new five-membered-ring peroxide acids, plakinic acid F (3) and epiplakinic acid F (4), and a new peroxide-lactone, plakortolide F (5), were isolated from a sponge of the genus Plakinastrella collected from Felicite Island, Seychelles. The structures were elucidated through spectral analysis. The free acids 3 and 4 exhibit moderate antifungal activity against Candida albicans with minimum inhibitory concentrations of 25 micrograms/mL (SDB) and 3.1 micrograms/mL (RPMI) for 3, and 25 micrograms/mL (SDB) and 6.25 micrograms/mL (RPMI) for 4, respectively. Both also showed moderate in vitro inhibition of Aspergillus fumigatus with IC90's of 25 micrograms/mL.
Chen
Y
Y
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., 5600 US 1 North, Ft. Pierce, Florida 34946, USA.
Killday
K B
KB
McCarthy
P J
PJ
Schimoler
R
R
Chilson
K
K
Selitrennikoff
C
C
Pomponi
S A
SA
Wright
A E
AE
D000818:Animals; D007536:Isomerism; D009682:Magnetic Resonance Spectroscopy; D008956:Models, Chemical; D010545:Peroxides / Q000737:chemistry / Q000302:isolation & purification*; D011161:Porifera / Q000737:chemistry*
D010545:Peroxides; C433591:epiplakinic acid F; C433590:plakinic acid F; C433592:plakortolide F