Control of Na+ spike backpropagation by intracellular signaling in the pyramidal neuron dendrites.
The integrative function of neurons depends on the somato-dendritic distribution and properties of voltage-gated ion channels. Sodium, potassium, calcium, and hyperpolarization-activated cyclic nucleotide-gated K+ (HCN) channels expressed in the dendrites can be modulated by a number of neurotransmitters and second-messenger systems. For example, activation of protein kinases leads to an increase in dendritic excitability by removing a slow inactivation of Na+ channels and decreasing the activity of transient K+ channels in the apical dendrites of hippocampal pyramidal neurons. Consequently, action potentials propagating along the dendrites can be modified significantly by a variety of neuromodulatory synaptic inputs.
Tsubokawa
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Section of Brain Information, Center for Brain Experiment, National Institute for Physiological Sciences, Okazaki, Japan.
D000109:Acetylcholine / Q000494:pharmacology; D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001923:Brain Chemistry; D015220:Calcium Channels / Q000502:physiology; D054815:Cyclic Nucleotide-Gated Cation Channels; D003712:Dendrites / Q000187:drug effects / Q000502:physiology; D005544:Forecasting; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000145:classification / Q000502:physiology*; D017136:Ion Transport / Q000502:physiology; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000502:physiology*; D018377:Neurotransmitter Agents / Q000502:physiology*; D009638:Norepinephrine / Q000502:physiology; D015221:Potassium Channels / Q000145:classification / Q000502:physiology; D017966:Pyramidal Cells / Q000502:physiology*; D051381:Rats; D015290:Second Messenger Systems; D012701:Serotonin / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D012964:Sodium / Q000502:physiology*; D015222:Sodium Channels / Q000502:physiology
D015220:Calcium Channels; D054815:Cyclic Nucleotide-Gated Cation Channels; D064428:Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels; D007473:Ion Channels; D009419:Nerve Tissue Proteins; D018377:Neurotransmitter Agents; D015221:Potassium Channels; D015222:Sodium Channels; D012701:Serotonin; D012964:Sodium; D019204:GTP-Binding Proteins; D000109:Acetylcholine; D009638:Norepinephrine