title: Features of distamycin preferential binding sites on natural DNA predicted using differential scanning calorimetry.
abstract: The interaction of distamycin with ColE1 DNA was examined by using differential scanning calorimetry (DSC) taking the helix-coil transition theory of DNA into consideration. Our results here strongly indicate that the affinity of distamycin to DNA, at a low distamycin concentration, depends highly on the DNA sequence, and preferential binding occurs to the sites of four to six successive A-T pairs having two or more successive G-C pairs on both their ends.
authors: College of Science and Engineering, Iwaki Meisei University, Fukushima, Japan.
authors: H
authors: H
authors: Ueta
authors: Y
authors: Y
authors: Maeda
authors: Y
authors: Y
authors: Kawai
mesh_terms: D003086:Bacteriocin Plasmids; D001665:Binding Sites; D002152:Calorimetry, Differential Scanning; D004247:DNA / Q000378:metabolism*; D004214:Distamycins / Q000378:metabolism*
chemical_list: D004214:Distamycins; C030000:stallimycin; D004247:DNA