Parallel-stranded hairpins containing 8-aminopurines. Novel efficient probes for triple-helix formation.
We describe novel oligomers with a greater propensity to form triplexes than oligomers containing only natural bases. They consist of a polypyrimidine sequence linked head-to-head with a polypurine sequence carrying one or several 8-aminoadenine or 8-aminoguanines. The presence of 8-aminopurines also stabilised the parallel-stranded duplex structure.
Aviñó
A
A
Cygene Spain S.L., Parc Científic de Barcelona, Baldiri i Reixac, 10-12, E-08028, Barcelona, Spain.
Morales
J C
JC
Frieden
M
M
de la Torre
B G
BG
García
R G
RG
Cubero
E
E
Luque
F J
FJ
Orozco
M
M
Azorín
F
F
Eritja
R
R
D001483:Base Sequence; D015342:DNA Probes; D011687:Purines / Q000737:chemistry*
D015342:DNA Probes; D011687:Purines