Nitric oxide production during the early neonatal period in small-for-gestational-age infants.
In a study of endogenous nitric oxide production in growth-retarded, very preterm newborns (<32 wk GA), urinary NOx/creatinine ratio and plasma guanosine 3',5'-cyclic monophosphate levels were determined during the early neonatal period. Newborns were divided into three groups: appropriate-for-gestational-age (AGA, n = 19), moderately small-for-gestational-age (SGA, n = 13) and severely SGA (n = 6) infants. Severely SGA infants showed significant higher values of nitric oxide derivatives during the first 24 h of life compared with the other groups.


CONCLUSIONS
An increased NO production is found in SGA infants during the first 24 h after birth. This may reflect an increased intrauterine nitric oxide production in the feto-placental circulation found in cases with intrauterine growth retardation,
Wijnberger
L D
LD
Department of Obstetrics and Neonatology, Wilhelmina Children's Hospital Utrecht, University Medical Center Utrecht, The Netherlands.
Krediet
T G
TG
Egberts
J
J
van Bel
F
F
D000704:Analysis of Variance; D016009:Chi-Square Distribution; D003404:Creatinine / Q000652:urine; D006152:Cyclic GMP / Q000097:blood; D005317:Fetal Growth Retardation / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D009569:Nitric Oxide / Q000652:urine*; D018709:Statistics, Nonparametric
D009569:Nitric Oxide; D003404:Creatinine; D006152:Cyclic GMP