title: XIAP, the guardian angel.
abstract: Controlling the activity of caspases is essential for the appropriate execution of cell death and the regulation of cell survival. One cellular inhibitor of apoptosis, XIAP, has emerged as a crucial regulator of caspases, and is itself subject to complex negative regulation.
authors: Children's Hospital of Eastern Ontario Research Institute, and AEgera Oncology Inc., 401 Smyth Road, Ottawa, Ontario K1H 8L1, Canada. martin@mgcheo.med.uottawa.ca
authors: M
authors: M
authors: Holcik
authors: R G
authors: RG
authors: Korneluk
mesh_terms: D000818:Animals; D017209:Apoptosis; D020169:Caspases / Q000737:chemistry / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000378:metabolism; D006801:Humans; D008954:Models, Biological; D008958:Models, Molecular; D011506:Proteins / Q000235:genetics / Q000378:metabolism*; D015398:Signal Transduction; D051636:X-Linked Inhibitor of Apoptosis Protein
chemical_list: D004791:Enzyme Inhibitors; D011506:Proteins; D051636:X-Linked Inhibitor of Apoptosis Protein; C496866:XIAP protein, human; D020169:Caspases