Successful treatment of an acquired haemorrhagic diathesis due to factor X deficiency with chemotherapy.
A 70-yr-old woman presented with a severe haemorrhagic diathesis due to an acquired factor X deficiency. A plasma infusion study showed that exogenous factor X was eliminated very effectively from the patient's circulation. A bone marrow biopsy was consistent with plasma cell dyscrasia. Neither an abdominal fat biopsy nor the bone marrow biopsy confirmed an amyloidosis, although clinically no other diagnosis seemed possible. Treatment with intermittent chemotherapy, consisting of vincristine, cytoxan and prednisone, yielded definite clinical and laboratory improvement.
De Jager
E
E
Department of Internal Medicine, Bronovo Hospital, The Hague, the Netherlands.
Bieger
R
R
Castel
A
A
Kluin
P M
PM
D000368:Aged; D000686:Amyloidosis / Q000150:complications; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001536:Bence Jones Protein / Q000652:urine; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D005171:Factor X Deficiency / Q000150:complications*; D005260:Female; D006474:Hemorrhagic Disorders / Q000188:drug therapy* / Q000209:etiology*; D006801:Humans; D010265:Paraproteinemias / Q000473:pathology; D010314:Partial Thromboplastin Time; D011241:Prednisone / Q000627:therapeutic use; D011517:Prothrombin Time; D014750:Vincristine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D014750:Vincristine; D003520:Cyclophosphamide; D001536:Bence Jones Protein; D011241:Prednisone