title: Cytotoxic polyacetylenes from the twigs of Ochanostachys amentacea.
abstract: Bioassay-guided investigation of the twigs of Ochanostachys amentacea using LNCaP (hormone-dependent human prostate cancer) cells as a monitor led to the isolation of three alkynes, the known (S)-17-hydroxy-9,11,13,15-octadecatetraynoic acid (minquartynoic acid, 1) and two novel analogues, (S)-17,18-dihydroxy-9,11,13,15-octadecatetraynoic acid (2) and (S)-17-hydroxy-15E-octadecen-9,11,13-triynoic acid (3). Compounds 1-3 were tested against a panel of human tumor cell lines and found to be significantly cytotoxic.
authors: Program for Collaborative Research in the Pharmaceutical Sciences and Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, USA.
authors: A
authors: A
authors: Ito
authors: B
authors: B
authors: Cui
authors: D
authors: D
authors: Chávez
authors: H B
authors: HB
authors: Chai
authors: Y G
authors: YG
authors: Shin
authors: K
authors: K
authors: Kawanishi
authors: L B
authors: LB
authors: Kardono
authors: S
authors: S
authors: Riswan
authors: N R
authors: NR
authors: Farnsworth
authors: G A
authors: GA
authors: Cordell
authors: J M
authors: JM
authors: Pezzuto
authors: A D
authors: AD
authors: Kinghorn
mesh_terms: D000480:Alkynes; D003603:Cytotoxins / Q000737:chemistry / Q000302:isolation & purification*; D004354:Drug Screening Assays, Antitumor; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification*; D006801:Humans; D019684:Magnoliopsida / Q000737:chemistry*; D053279:Polyynes; D014407:Tumor Cells, Cultured
chemical_list: D000480:Alkynes; D003603:Cytotoxins; D005231:Fatty Acids, Unsaturated; C417933:minquartynoic acid; D053279:Polyynes