title: Depressive state and regional cerebral activity in cancer patients - a preliminary study.
abstract: BACKGROUND
  The aim of this study was to investigate influences of depressive states, chemotherapy and existence of remaining tumors on the regional brain activity of cancer patients.
  
  
  METHODS
  Positron emission tomography with 18F-fluorodeoxyglucose was performed on 21 patients with various types of cancer. Their brain images were compared to 10 age- and gender-matched control data using statistical parametric mapping (SPM). The patients were subgrouped into the with and without depression based on the scores on Zung's self-rating depression scale (SDS), with and without previous chemotherapy, and with and without existence of remaining tumors.
  
  
  RESULTS
  Significant metabolic reduction was detected in the cingulate gyrus, prefrontal, dorsolateral prefrontal, temporoparietal cortices and basal ganglia in cancer patients. These findings were close to known lesions of major depression. Intra-group comparisons showed that these hypometabolic findings were associated with the depth of depressive state. Influences of chemotherapy and remaining tumors on the cerebral cortex seemed to be weaker than that of psychological factors.
  
  
  CONCLUSIONS
  The present pilot study suggests that frontal hypoactivity commonly seen in cancer patients is likely to be associated with depression rather than chemotherapy or remaining tumors. A brain mapping technique might be useful in evaluating neuropsychiatric problems in cancer patients.
authors: Department of Nuclear Medicine, University Hospital Freiburg, Germany. matashiro@hotmail.com
authors: M
authors: M
authors: Tashiro
authors: F D
authors: FD
authors: Juengling
authors: M J
authors: MJ
authors: Reinhardt
authors: M
authors: M
authors: Mix
authors: H
authors: H
authors: Kumano
authors: K
authors: K
authors: Kubota
authors: M
authors: M
authors: Itoh
authors: H
authors: H
authors: Sasaki
authors: E U
authors: EU
authors: Nitzsche
authors: E
authors: E
authors: Moser
mesh_terms: D000328:Adult; D000368:Aged; D003863:Depression / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D019788:Fluorodeoxyglucose F18 / Q000378:metabolism; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D014055:Tomography, Emission-Computed
chemical_list: D019788:Fluorodeoxyglucose F18