Interaction of disintegrins with human neutrophils induces cytoskeleton reorganization, focal adhesion kinase activation, and extracellular-regulated kinase-2 nuclear translocation, interfering with the chemotactic function.
Coelho
A L
AL
Departamento de Farmacologia, Instituto de Biologia, Universidade do Estado do Rio de Janeiro, Brazil.
De Freitas
M S
MS
Mariano-Oliveira
A
A
Oliveira-Carvalho
A L
AL
Zingali
R B
RB
Barja-Fidalgo
C
C
D000199:Actins / Q000502:physiology; D021581:Active Transport, Cell Nucleus / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects* / Q000502:physiology; D003599:Cytoskeleton / Q000187:drug effects* / Q000502:physiology; D019483:Disintegrins / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; D006801:Humans; D066298:In Vitro Techniques; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D020928:Mitogen-Activated Protein Kinases / Q000378:metabolism*; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism / Q000502:physiology; D011505:Protein-Tyrosine Kinases / Q000378:metabolism* / Q000502:physiology; D015398:Signal Transduction
D000199:Actins; D019483:Disintegrins; D011505:Protein-Tyrosine Kinases; D051417:Focal Adhesion Kinase 1; D051416:Focal Adhesion Protein-Tyrosine Kinases; C496050:PTK2 protein, human; D019950:Mitogen-Activated Protein Kinase 1; D020928:Mitogen-Activated Protein Kinases