Somamides A and B, two new depsipeptide analogues of dolastatin 13 from a Fijian cyanobacterial assemblage of Lyngbya majuscula and Schizothrix species.
Somamides A (1) and B (2) were isolated from assemblages of the marine cyanobacteria Lyngbya majusculaand Schizothrix sp. from the Fijian Islands. These new depsipeptides are analogous in structure to the cyanobacterial metabolite symplostatin 2 (4) as well as dolastatin 13 (3), originally isolated from Dolabella auricularia, further demonstrating the cyanobacterial origin of the dolastatins.
Nogle
L M
LM
College of Pharmacy, Oregon State University, Corvallis, Oregon 97331, USA.
Williamson
R T
RT
Gerwick
W H
WH
D000596:Amino Acids / Q000737:chemistry; D000458:Cyanobacteria / Q000737:chemistry*; D047630:Depsipeptides; D005367:Fiji; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009842:Oligopeptides / Q000737:chemistry / Q000302:isolation & purification*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification*; D016339:Spectrometry, Mass, Fast Atom Bombardment
D000596:Amino Acids; D047630:Depsipeptides; D009842:Oligopeptides; D010456:Peptides, Cyclic; C433549:dolastatin 13; C433548:somamide A; C433547:somamide B