The chemistry and immunochemistry of blood group A, B, H, and Lewis antigens: past, present and future.
This article traces reseach on the chemistry and immunochemistry of blood group A, B, H, and Lewis antigens from early work on the identification of soluble sources of these antigens, through the elucidation of the structures of the carbohydrate epitopes responsible for these specificities, to recent work on exploring their possible use as cancer vaccines. The various approaches used in the isolation of oligosaccharides from mucins for use in structural studies are discussed, as are recent efforts in the chemical systhesis of blood group-active oligosaccharides.
Lloyd
K O
KO
Immunology Program, Sloan-Kettering Institute, New York, NY 10021, USA. k-lloyd@ski.mskcc.org
D000017:ABO Blood-Group System / Q000737:chemistry* / Q000266:history / Q000276:immunology; D000595:Amino Acid Sequence; D002240:Carbohydrate Sequence; D006017:Glycolipids / Q000737:chemistry / Q000276:immunology; D006023:Glycoproteins / Q000737:chemistry / Q000276:immunology; D049673:History, 20th Century; D006801:Humans; D007120:Immunochemistry; D007983:Lewis Blood Group Antigens / Q000737:chemistry* / Q000266:history / Q000276:immunology; D008969:Molecular Sequence Data; D009077:Mucins / Q000737:chemistry; D009369:Neoplasms / Q000097:blood / Q000737:chemistry / Q000276:immunology; D009844:Oligosaccharides / Q000138:chemical synthesis / Q000737:chemistry / Q000302:isolation & purification; D011134:Polysaccharides / Q000737:chemistry; D014481:United States
D000017:ABO Blood-Group System; D006017:Glycolipids; D006023:Glycoproteins; D007983:Lewis Blood Group Antigens; D009077:Mucins; D009844:Oligosaccharides; D011134:Polysaccharides