Palladium-catalyzed addition of alcohol pronucleophiles to alkylidenecyclopropanes.
Palladium-catalyzed addition of alcohol pronucleophiles 1 to alkylidenecyclopropane derivatives 2 afforded the corresponding allylic ethers 3 in excellent to moderate yields. Catalyst optimization indicated the Pd(PPh3)4-P(o-tolyl)3 combination as the best system among all catalysts tested. Intramolecular reaction also proceeded smoothly. A plausible mechanism for this catalytic reaction was proposed.
Camacho
D H
DH
Department of Chemistry, Graduate School of Science and Institute for Chemical Reaction Science, Tohoku University, Sendai 980-8578, Japan.
Nakamura
I
I
Saito
S
S
Yamamoto
Y
Y