title: Colonic pneumatosis intestinalis in preterm infants: different to necrotising enterocolitis with a more benign course?
abstract: Necrotising enterocolitis (NEC) is the predominant immaturity-associated disease of the bowel in the preterm neonate and leads to substantial mortality and long-term morbidity. Diagnostic features of NEC include, apart from the clinical presentation, laboratory and radiological parameters. Pneumatosis intestinalis (PI) on abdominal radiographs is regarded as a criterion of definitive proof for this disease entity. The objective of this presentation is to link the topographic pattern of PI to the clinical course in cases of suspected NEC. We report two cases of radiological appearance of colonic PI indicative of NEC without associated laboratory and/or macroscopic evidence of the disease, and with minor clinical symptoms only. Data from animal studies indicate that decreased blood supply to the small bowel is associated with more extensive bowel damage as compared to impaired colonic perfusion. Therefore the topographical distribution of PI might be a more specific sign as the general presence or absence of PI.
  
  
  CONCLUSIONS
  The topographical pattern of pneumatosis intestinalis may be predictive of the clinical course of inflammatory bowel disease in preterm infants.
authors: Department of Neonatology, Charité Virchow Hospital, Humboldt University, Berlin, Germany. thomas@hoehn@charite.de
authors: T
authors: T
authors: Hoehn
authors: B
authors: B
authors: Stöver
authors: C
authors: C
authors: Bührer
mesh_terms: D003937:Diagnosis, Differential; D004200:Diseases in Twins / Q000175:diagnosis; D020345:Enterocolitis, Necrotizing / Q000175:diagnosis* / Q000000981:diagnostic imaging; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000175:diagnosis*; D011006:Pneumatosis Cystoides Intestinalis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D011859:Radiography