Rifampicin-induced lupus erythematosus.
Rifampicin has been prescribed throughout the world for over 20 years, yet only four cases of rifampicin-induced lupus erythematosus (LE) have been reported. Rifampicin-induced LE is associated with combination therapy with clarithromycin or ciprofloxacin. These drugs are all metabolized through the cytochrome P450 liver enzyme system and combined usage may lead to higher rifampicin blood levels. Drug-induced LE differs from systemic LE; cutaneous manifestations, although uncommon, are an important clue to the diagnosis. We report a case of rifampicin-induced LE presenting with florid cutaneous features.
Patel
G K
GK
Department of Dermatology, University Hospital of Wales, Cardiff, Wales, UK. patelgk@cardiff.ac.uk
Anstey
A V
AV
D000368:Aged; D000904:Antibiotics, Antitubercular / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced*; D008297:Male; D012293:Rifampin / Q000009:adverse effects*
D000904:Antibiotics, Antitubercular; D012293:Rifampin