Markers of bone turnover in postmenopausal women receiving hormone replacement therapy.
We investigated the effects of hormone replacement therapy (n = 27) on biochemical markers of bone turnover in a cross-sectional study of 127 postmenopausal women (according to WHO guidelines 18 patients had normal bone mineral density and 109 suffered from bone loss). Urinary excretion of free deoxypyridinoline and C- or N-telopeptide fragments of type I collagen served as bone resorption markers, serum osteocalcin as a bone formation marker. In women with no hormone replacement therapy, only C- and N-telopeptides correlated significantly with the lumbal T-score as an index for bone mineral density. Patients with bone loss receiving hormone replacement therapy exhibited significantly lower C-telopeptide, N-telopeptide and osteocalcin levels than those with no therapy (mean -45%, -43% and -26%, respectively), while deoxypyridinoline showed no significant differences. Among the markers investigated, C- and N-telopeptides seemed to be more reliable to detect therapeutic effects on bone metabolism. We present a preliminary model to evaluate bone turnover and resorption/formation rate.
Hamwi
A
A
Department of Laboratory Medicine, University of Vienna, Austria.
Ganem
A H
AH
Grebe
C
C
Kerschan-Schindl
K
K
Preisinger
E
E
Boschitsch
E
E
Bieglmayer
C
C
D000368:Aged; D000596:Amino Acids / Q000652:urine; D015415:Biomarkers / Q000652:urine*; D015519:Bone Density; D001862:Bone Resorption / Q000517:prevention & control / Q000652:urine*; D001842:Bone and Bones / Q000378:metabolism*; D003094:Collagen / Q000652:urine; D024042:Collagen Type I; D003430:Cross-Sectional Studies; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D015675:Osteocalcin / Q000652:urine; D015663:Osteoporosis, Postmenopausal / Q000517:prevention & control / Q000652:urine*; D010455:Peptides / Q000652:urine; D017698:Postmenopause / Q000652:urine*
D000596:Amino Acids; D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; C036020:deoxypyridinoline; D003094:Collagen