Do Schwann cells stop, DR(o)P2, and roll?
Dystrophin-dystroglycan complexes in Schwann cells may play a role in both signaling and structural interactions between the extracellular matrix and the cytoskeleton. Sherman et al. (2001) show that a new complex containing dystrophin-related protein 2 (DRP2) and periaxin plays a role in Schwann cell-basal lamina interactions and PNS myelination.
Wrabetz
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San Raffaele Scientific Institute, DIBIT, Via Olgettina 58, 20132, Milan, Italy.
Feltri
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ML
D000818:Animals; D003598:Cytoskeletal Proteins / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism*; D009124:Muscle Proteins; D009186:Myelin Sheath / Q000502:physiology*; D012583:Schwann Cells / Q000378:metabolism*
D003598:Cytoskeletal Proteins; D008565:Membrane Proteins; D009124:Muscle Proteins; C099589:dystrophin-related protein 2; C086745:periaxin