Monitoring response to convection-enhanced taxol delivery in brain tumor patients using diffusion-weighted magnetic resonance imaging.
Convection-enhanced drug delivery (CEDD) is a novel approach to enhance the delivery of drugs directly into brain tumors. We have used diffusion-weighted MRI (DWMRI) to monitor the effects of intratumoral CEDD in three brain tumor patients treated with Taxol. Clear changes in the images and the water diffusion parameters were observed shortly after the initiation of treatment. Initially, a bright area corresponding to decreased diffusion appeared, followed by the appearance of a dark area of increased diffusion within the bright area. The time to appearance of the dark area varied among the patients, suggesting different response rates. In this work, we have demonstrated the feasibility of using DWMRI as a noninvasive tool to achieve unique early tissue characterization not attainable by other conventional imaging methods.
Mardor
Y
Y
Advanced Technology Center, The Chaim Sheba Medical Center, Tel-Hashomer 52621, Israel.
Roth
Y
Y
Lidar
Z
Z
Jonas
T
T
Pfeffer
R
R
Maier
S E
SE
Faibel
M
M
Nass
D
D
Hadani
M
M
Orenstein
A
A
Cohen
J S
JS
Ram
Z
Z
D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D018481:Convection; D004058:Diffusion; D016503:Drug Delivery Systems; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods; D008991:Monitoring, Physiologic / Q000379:methods; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D017239:Paclitaxel / Q000008:administration & dosage*; D014867:Water / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D014867:Water; D017239:Paclitaxel