Successful treatment of Acanthamoeba meningitis with combination oral antimicrobials.
Acanthamoeba was implicated as the causative agent of chronic meningitis in three apparently immunocompetent children. Diagnosis was established by cerebrospinal fluid wet mount examination and culture. Two children improved rapidly with combination oral therapy composed of trimethoprim-sulfamethoxazole, rifampin and ketoconazole.
Singhal
T
T
Department of Pediatrics, All India Institute of Medical Sciences, New Delhi.
Bajpai
A
A
Kalra
V
V
Kabra
S K
SK
Samantaray
J C
JC
Satpathy
G
G
Gupta
A K
AK
D000048:Acanthamoeba; D000284:Administration, Oral; D000562:Amebiasis / Q000175:diagnosis / Q000188:drug therapy*; D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis / Q000175:diagnosis / Q000188:drug therapy* / Q000469:parasitology*; D012293:Rifampin / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D000935:Antifungal Agents; D004791:Enzyme Inhibitors; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D007654:Ketoconazole; D012293:Rifampin