Human natriuretic peptides exhibit antimicrobial activity.
Here we describe a novel function for members of the well-characterized human natriuretic peptide family. Human "brain-type natriuretic peptide" (hBNP-32) as well as other members of this peptide class are antimicrobially active against Gram-positive and Gram-negative bacteria and yeast in a dose-dependent manner. This activity of natriuretic peptides is comparable to that of known antimicrobial peptides such as casocidins or magainins.
Krause
A
A
IPF PharmaCeuticals GmbH, Hannover, Germany.
Liepke
C
C
Meyer
M
M
Adermann
K
K
Forssmann
W G
WG
Maronde
E
E
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000494:pharmacology*; D009320:Atrial Natriuretic Factor / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects*; D006801:Humans; D008826:Microbial Sensitivity Tests; D020097:Natriuretic Peptide, Brain / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*; D013210:Staphylococcus / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D010446:Peptide Fragments; D020097:Natriuretic Peptide, Brain; C056452:Ularitide; D009320:Atrial Natriuretic Factor