title: Existence of a genetic risk factor on chromosome 5q in Italian coeliac disease families.
abstract: Coeliac disease (CD) is a malabsorptive disorder of the small intestine resulting from ingestion of gluten. The HLA risk factors involved in CD are well known but do not explain the whole genetic susceptibility. Several regions of potential linkage on chromosomes 3q, 5q, 10q, 11q, 15q and 19q have already been reported in the literature. These six regions were analyzed with the Maximum Lod Score method on a dense set of markers. A new sample of 89 Italian sibpairs was available for study. There was no evidence for linkage for any of the regions tested, except for chromosome 5q. For this region, our data, as well as a sample of 93 sibpairs from our first genome screen (Greco et al. 1998), are compatible with the presence of a risk factor for CD with a moderate effect.
authors: Dept. of Pediatrics, University of Naples Federico II, Italy. ydongre@unina.it
authors: L
authors: L
authors: Greco
authors: M C
authors: MC
authors: Babron
authors: G R
authors: GR
authors: Corazza
authors: S
authors: S
authors: Percopo
authors: R
authors: R
authors: Sica
authors: F
authors: F
authors: Clot
authors: M C
authors: MC
authors: Fulchignoni-Lataud
authors: P
authors: P
authors: Zavattari
authors: P
authors: P
authors: Momigliano-Richiardi
authors: G
authors: G
authors: Casari
authors: P
authors: P
authors: Gasparini
authors: R
authors: R
authors: Tosi
authors: V
authors: V
authors: Mantovani
authors: S
authors: S
authors: De Virgiliis
authors: G
authors: G
authors: Iacono
authors: A
authors: A
authors: D'Alfonso
authors: H
authors: H
authors: Selinger-Leneman
authors: A
authors: A
authors: Lemainque
authors: J L
authors: JL
authors: Serre
authors: F
authors: F
authors: Clerget-Darpoux
mesh_terms: D002446:Celiac Disease / Q000208:ethnology / Q000235:genetics*; D002875:Chromosomes; D002895:Chromosomes, Human, Pair 5; D005192:Family Health; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007558:Italy; D008126:Lod Score; D008297:Male; D012307:Risk Factors
chemical_list: D005819:Genetic Markers