title: Evolving responsively: adaptive mutation.
abstract: A basic principle of genetics is that the likelihood that a particular mutation occurs is independent of its phenotypic consequences. The concept of adaptive mutation seemed to challenge this principle with the discoveries of mutations stimulated by stress, some of which allow adaptation to the stress. The emerging mechanisms of adaptive genetic change cast evolution, development and heredity into a new perspective, indicating new models for the genetic changes that fuel these processes.
authors: Departments of Molecular and Human Genetics, Biochemistry, and Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030-3411, USA. smr@bcm.tmc.edu
authors: S M
authors: SM
authors: Rosenberg
mesh_terms: D000222:Adaptation, Physiological / Q000235:genetics*; D000818:Animals; D004926:Escherichia coli / Q000235:genetics* / Q000502:physiology; D019143:Evolution, Molecular; D006801:Humans; D008957:Models, Genetic; D015233:Models, Statistical; D009154:Mutation / Q000502:physiology*; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000235:genetics* / Q000502:physiology; D012641:Selection, Genetic