title: Modified Donnan potentials for ion transport through biological ion channels.
abstract: In the classical study of ion transport through charged membranes, Donnan potentials are used to approximate the difference between the applied electrostatic potential and the potential at the liquid/membrane interface. For very thin membranes (e.g., biological lipid bilayers), this discontinuous approximation of the potential is not sufficient. Here we derive a modification to the classic Donnan potential for ion transport through a biological ion channel embedded in a lipid bilayer. We also show how to derive the classic Donnan potential without the usual assumptions and estimate the amount of space charge at the liquid/membrane interface.
authors: Department of Physiology and Biophysics, University of Miami School of Medicine, P.O. Box 016430, Miami, Florida 33101-6430, USA. dirkg@chroma.med.miami.edu
authors: D
authors: D
authors: Gillespie
authors: R S
authors: RS
authors: Eisenberg
mesh_terms: D001703:Biophysics / Q000379:methods*; D018118:Chloride Channels / Q000737:chemistry; D007473:Ion Channels / Q000502:physiology*; D017136:Ion Transport; D007477:Ions; D008051:Lipid Bilayers / Q000737:chemistry*; D015233:Models, Statistical; D008962:Models, Theoretical; D015221:Potassium Channels / Q000737:chemistry; D015222:Sodium Channels / Q000737:chemistry; D055672:Static Electricity
chemical_list: D018118:Chloride Channels; D007473:Ion Channels; D007477:Ions; D008051:Lipid Bilayers; D015221:Potassium Channels; D015222:Sodium Channels