title: Presence of fluticasone propionate on human nasal mucosal surface and in human nasal tissue over a period of 24 h after intranasal application.
abstract: BACKGROUND
  Once-daily use of nasally applied glucocorticoids was demonstrated to be effective in the treatment of allergic rhinitis. The aim of the study was to measure concentrations of fluticasone propionate (FP) in nasal secretion and nasal tissue over a period of 1 day after a single application of 100 microg FP.
  
  
  METHODS
  Twenty-six patients applied nasal FP spray at different time intervals before surgery. Cotton swabs, used to clean the mucosal surface, and resected nasal tissue were extracted. FP concentrations were determined by RIA.
  
  
  RESULTS
  FP was found in nasal secretions in concentrations from 15 to 1 microg/g over a period of 20 h, and in nasal tissue in concentrations from 200 to 13 ng/g up to 24 h after the single application.
  
  
  CONCLUSIONS
  The long-persisting high concentrations of FP provide the pharmacokinetic basis for once-daily treatment.
authors: Institut für Pharmazeutische Chemie der Westfälischen Wilhelms-Universität, Münster, Germany.
authors: U
authors: U
authors: Bonsmann
authors: C
authors: C
authors: Bachert
authors: K W
authors: KW
authors: Delank
authors: P
authors: P
authors: Rohdewald
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D000730:Androstadienes / Q000032:analysis / Q000493:pharmacokinetics / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000032:analysis* / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D000068298:Fluticasone; D006801:Humans; D008297:Male; D008875:Middle Aged; D009092:Mucous Membrane / Q000737:chemistry / Q000187:drug effects*; D009297:Nasal Mucosa / Q000737:chemistry / Q000187:drug effects*; D011863:Radioimmunoassay / Q000379:methods; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000730:Androstadienes; D000893:Anti-Inflammatory Agents; D000068298:Fluticasone