title: Perforator-based flap in rats: a new experimental model.
abstract: A new type of flap, the perforator-based flap, has been described in the last decade. It has been used successfully as a pedicle or free flap by many plastic surgeons. There is no animal model for research, although these flaps have gained popularity in clinical use. We created a perforator-based flap model in the rat (a perforator-based flap group and two control groups; 10 rats in each group) and evaluated the survival characteristics of the new flap. The abdominal skin flap was elevated based on the second perforator of the right superior deep epigastric artery and then sutured to its original bed. In the first control group, the same flap was elevated with a subcutaneous pedicle without any perforator; in the second control group, a right-sided, random-pattern pedicle abdominal skin flap with the same dimensions and location was elevated and sutured to its original bed. Flap survival was studied, and microangiography and histologic studies were performed. The amount of viable skin in the three groups was compared 1 week later. The area of surviving skin paddles in the experimental group ranged from 74 to 83 percent; in the first control group, it was 0 percent; and in the second control group, it ranged from 29 to 44 percent (p < 0.001 and p < 0.001, respectively). There was a predictable and constant area of necrosis in the model. The results of this study demonstrate that most of the abdominal skin of the rat can survive on the basis of a single musculocutaneous perforator vessel. This flap can be easily elevated, and it can be used as a reliable model for flap research.
authors: Department of Plastic and Reconstructive Surgery, Akdeniz University School of Medicine, Antalya, Turkey. seckin_oksar@yahoo.com
authors: H S
authors: HS
authors: Okşar
authors: O K
authors: OK
authors: Coşkunfirat
authors: H E
authors: HE
authors: Ozgentaş
mesh_terms: D000005:Abdomen; D000792:Angiography; D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D005260:Female; D006085:Graft Survival; D008297:Male; D008852:Microradiography; D023421:Models, Animal; D051381:Rats; D017207:Rats, Sprague-Dawley; D019651:Plastic Surgery Procedures; D012867:Skin / Q000473:pathology; D013524:Surgical Flaps / Q000098:blood supply*