title: Synthesis of 5-fluorouracil-imprinted polymers with multiple hydrogen bonding interactions.
abstract: The antitumor active compound 5-fluorouracil (5-FU) was used as a target molecule and 5-FU-imprinted polymers were synthesized using 2,6-bis(acrylamido)pyridine and/or 2-(trifluoromethyl)acrylic acid as functional monomers. The 5-FU-imprinted polymers showed a higher affinity for 5-FU than that for 5-FU derivatives. By using both functional monomers simultaneously, the affinity and separation for 5-FU were improved.
authors.affiliation: Laboratory of Synthetic Biochemistry, Faculty of Information Sciences, Hiroshima City University, 3-4-1 Ozuka-higashi, Asaminami-ku, Hiroshima 731-3194, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kugimiya
authors.forename: T
authors.initials: T
authors.lastname: Mukawa
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
mesh_terms: D005472:Fluorouracil / Q000032:analysis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011108:Polymers
chemical_list: D011108:Polymers; D005472:Fluorouracil