title: Polyamines: new cues in cellular signal transduction.
abstract: The naturally occurring polyamines putrescine, spermidine, and spermine are involved in signal transduction. This has been demonstrated by using inhibitors for polyamine biosynthesis (such as alpha-difluoromethylornithine) or adding polyamines to cultured cells. Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclear protooncogenes (myc, jun, and fos).
authors.affiliation: Department of Molecular Biology, Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
authors.forename: U
authors.initials: U
authors.lastname: Bachrach
authors.forename: Y C
authors.initials: YC
authors.lastname: Wang
authors.forename: A
authors.initials: A
authors.lastname: Tabib
mesh_terms: D000818:Animals; D002455:Cell Division / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology; D002468:Cell Physiological Phenomena; D015870:Gene Expression / Q000502:physiology; D009857:Oncogenes / Q000235:genetics; D011073:Polyamines / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
chemical_list: D011073:Polyamines