title: Doxylamine overdose as a potential cause of rhabdomyolysis.
abstract: Doxylamine succinate, an over-the-counter antihistamine, is commonly used as a nighttime sleep aid in the short-term management of insomnia. It is also used in combination with antitussive and decongestant agents for the temporary relief of common cold symptoms. Doxylamine is frequently involved in accidental and intentional overdoses. Rhabdomyolysis and secondary acute renal failure are rare but potentially serious complications, making early recognition and treatment essential. With the large number of nonprescription antihistamines and sleep aids available to the general public, it is important to keep in mind that overdose is a potential problem. The complications associated with overdose of these medications are just as life threatening as those associated with prescription drugs. A high index of suspicion and evaluation of rhabdomyolysis is warranted in antihistamine toxicity. We report an observation of severe rhabdomyolysis associated with doxylamine overdose.
authors.affiliation: Department of Medicine, MCP Hahnemann University, Philadelphia, Pennsylvania 19102, USA. bl27@drexel.edu
authors.forename: B
authors.initials: B
authors.lastname: Leybishkis
authors.forename: P
authors.initials: P
authors.lastname: Fasseas
authors.forename: K F
authors.initials: KF
authors.lastname: Ryan
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy; D000328:Adult; D004319:Doxylamine / Q000008:administration & dosage* / Q000009:adverse effects* / Q000031:analogs & derivatives*; D062787:Drug Overdose / Q000150:complications; D006634:Histamine H1 Antagonists / Q000008:administration & dosage* / Q000009:adverse effects*; D006801:Humans; D008297:Male; D004366:Nonprescription Drugs / Q000008:administration & dosage / Q000009:adverse effects; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000150:complications / Q000628:therapy; D012651:Self Medication
chemical_list: D006634:Histamine H1 Antagonists; D004366:Nonprescription Drugs; D004319:Doxylamine; C035385:doxylamine succinate