title: Pulmonary hemorrhage in association with negative pressure edema in an intubated patient.
abstract: Negative pressure pulmonary edema due to upper airway obstruction following extubation is a well-recognized problem. However, frank pulmonary hemorrhage as a manifestation of upper airway obstruction is uncommon. We report a case of significant pulmonary hemorrhage and negative pressure pulmonary edema in an intubated patient. Bronchoscopy showed a collection of blood in the right lower lobe of the lungs, suggesting a localized source of bleeding. There have been two previously reported cases of pulmonary hemorrhage after upper airway obstruction. One suggested that the bleeding was due to damage to the pulmonary capillaries, the other that it was due to disruption of the bronchial vessels. We feel that in our case there was some indication that the pulmonary bleeding was a result of bronchial vessel damage. A number of factors might have been involved in its development, including negative pulmonary pressure, recent respiratory tract infection, and positive airways pressure (due to coughing).
authors.affiliation: Department of Anaesthesia and Intensive Care, Singapore General Hospital, Republic of Singapore.
authors.forename: Y
authors.initials: Y
authors.lastname: Sow Nam
authors.forename: D
authors.initials: D
authors.lastname: Garewal
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000209:etiology*; D000768:Anesthesia, General; D001784:Blood Gas Analysis; D004232:Diuretics / Q000627:therapeutic use; D005665:Furosemide / Q000627:therapeutic use; D006470:Hemorrhage / Q000503:physiopathology*; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008171:Lung Diseases / Q000150:complications / Q000503:physiopathology*; D008297:Male; D010100:Oxygen / Q000097:blood; D011654:Pulmonary Edema / Q000150:complications / Q000503:physiopathology*
chemical_list: D004232:Diuretics; D005665:Furosemide; D010100:Oxygen