title: Ionotropic and metabotropic GABA and glutamate receptors in primate basal ganglia.
abstract: The functions of glutamate and GABA in the CNS are mediated by ionotropic and metabotropic, G protein-coupled, receptors. Both receptor families are widely expressed in basal ganglia structures in primates and nonprimates. The recent development of highly specific antibodies and/or cDNA probes allowed the better characterization of the cellular localization of various GABA and glutamate receptor subtypes in the primate basal ganglia. Furthermore, the use of high resolution immunogold techniques at the electron microscopic level led to major breakthroughs in our understanding of the subsynaptic and subcellular localization of these receptors in primates. In this review, we will provide a detailed account of the current knowledge of the localization of these receptors in the basal ganglia of humans and monkeys.
authors.affiliation: Division of Neuroscience, Yerkes Regional Primate Research Center, Emory University, 954, Gatewood Rd NE, Atlanta, GA 30322, USA. yolands@rmy.emory.edu
authors.forename: Y
authors.initials: Y
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Charara
authors.forename: M
authors.initials: M
authors.lastname: Paquet
authors.forename: J Z
authors.initials: JZ
authors.lastname: Kieval
authors.forename: J F
authors.initials: JF
authors.lastname: Paré
authors.forename: J E
authors.initials: JE
authors.lastname: Hanson
authors.forename: G W
authors.initials: GW
authors.lastname: Hubert
authors.forename: M
authors.initials: M
authors.lastname: Kuwajima
authors.forename: A I
authors.initials: AI
authors.lastname: Levey
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000378:metabolism* / Q000648:ultrastructure; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D009434:Neural Pathways / Q000378:metabolism / Q000648:ultrastructure; D011323:Primates / Q000033:anatomy & histology / Q000378:metabolism*; D018079:Receptors, GABA / Q000378:metabolism*; D018094:Receptors, Metabotropic Glutamate / Q000378:metabolism*; D013569:Synapses / Q000378:metabolism* / Q000648:ultrastructure; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D018079:Receptors, GABA; D018094:Receptors, Metabotropic Glutamate; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid