Cholecystokinin/dopamine/GABA interactions in the nucleus accumbens: biochemical and functional correlates.
The present article reviews our recent biochemical and microdialysis studies showing the evidence for an antagonistic CCK(B)/D(2) receptor interaction in the regulation of dopaminergic transmission in the nucleus accumbens and GABAergic transmission in the ipsilateral ventral pallidum. Since the nucleus accumbens plays a crucial role in regulating the output from the limbic system and consequently motivation, it may be speculated that a dysregulation of this receptor interaction may have consequences in a wide range of central nervous system disorders.
Tanganelli
S
S
Department of Clinical and Experimental Medicine, Section of Pharmacology, University of Ferrara, 44100 Ferrara, Italy. frl@unife.it
Fuxe
K
K
Antonelli
T
T
O'Connor
W T
WT
Ferraro
L
L
D000818:Animals; D002493:Central Nervous System Diseases / Q000378:metabolism; D002766:Cholecystokinin / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D018697:Nootropic Agents / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000378:metabolism*; D010165:Palladium / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D012844:Sincalide / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
C090019:8-sulfocholecystokinin octapeptide; D018697:Nootropic Agents; D005680:gamma-Aminobutyric Acid; D010165:Palladium; D002766:Cholecystokinin; D012844:Sincalide; D004298:Dopamine