title: Increased extraction of endothelin-1 across the failing human heart.
abstract: In this study we compared the transcardiac gradient of plasma endothelin-1 in patients with normal ventricular function and in those with congestive heart failure. We documented a significant reduction in the plasma levels of endothelin-1 across the failing human heart, an effect not seen in patients with normal left ventricular function.
authors.affiliation: Mount Sinai Hospital, Division of Cardiology, Department of Medicine, University of Toronto, Toronto, Ontario, Canada.
authors.forename: E R
authors.initials: ER
authors.lastname: Azevedo
authors.forename: D J
authors.initials: DJ
authors.lastname: Stewart
authors.forename: J D
authors.initials: JD
authors.lastname: Parker
mesh_terms: D016022:Case-Control Studies; D019332:Endothelin-1 / Q000097:blood* / Q000378:metabolism; D005260:Female; D006333:Heart Failure / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D019332:Endothelin-1