PROLACTIN-deficiency in adult offspring of diabetic mothers.
Maternal diabetes induces fetal alterations, resulting in lasting consequences for the glucose tolerance of the offspring over several generations. In our experimental rat model, circulating prolactin, oestradiol, progesterone and corticosterone levels, known to influence insulin secretion and action, are determined in plasma of female adult offspring of mildly and severely diabetic mothers. Prolactin and progesterone levels are equally low in both groups as compared to controls, stressing the involvement of the CNS in the transgeneration effect; oestradiol and corticosterone levels are normal. No correlation is found between these hormonal alterations and the known differences in glucose tolerance.
Aerts
L
L
Department of Obstetrics and Gynecology, U.Z. Gasthuisberg, K.U. Leuven, Belgium. Leonard.Aerts@uz.kuleuven.ac.be
Van Bree
R
R
Van Assche
F A
FA
D000818:Animals; D003345:Corticosterone / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood; D005260:Female; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D011297:Prenatal Exposure Delayed Effects; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood* / Q000172:deficiency*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values
D007328:Insulin; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin; D003345:Corticosterone