Inhibitory effect of sofalcone on tumor necrosis factor-alpha and interleukin-1 beta production in human monocytes stimulated by Helicobacter pylori water extract.
We investigated the effect of sofalcone, a synthetic flavonoid derivative of sophoradin, on tumor necrosis factor (TNF)-alpha and interleukin (IL)-1 beta production in human monocytes stimulated by Helicobacter pylori water extract. H. pylori water extract significantly stimulated TNF-alpha and IL-1 beta production by monocytes while incubation with sofalcone (10 micrograms/ml and 50 micrograms/ml) significantly inhibited this increase in TNF-alpha and IL-1 beta production. These results suggest that sofalcone could be used to improve H. pylori-associated gastric mucosal inflammation through inhibition of proinflammatory cytokine production.
Fujiwara
Y
Y
Department of Gastroenterology, Osaka City University Medical School, 1-4-3 Asahimachi, Abenoku Osaka 545-8585, Japan. yasu@med.osaka-cu.acjp
Higuchi
K
K
Fukuda
T
T
Watanabe
T
T
Tominaga
K
K
Arakawa
T
T
D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002599:Chalcone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D047188:Chalcones; D004305:Dose-Response Relationship, Drug; D016480:Helicobacter pylori / Q000276:immunology; D006801:Humans; D066298:In Vitro Techniques; D007375:Interleukin-1 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D009000:Monocytes / Q000187:drug effects* / Q000276:immunology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000096:biosynthesis
D000897:Anti-Ulcer Agents; D047188:Chalcones; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; C035032:sofalcone; D002599:Chalcone