[Use of parameters of the lipid peroxidation-regulating system for assessing the biological consequences of the combined effect of Tween-80 and low-dose X-rays].
The effect of surfactant Tween 80 on the intensity of lipid peroxidation (LPO), the antioxidant status of liver and the DNA content in blood plasma of mice was studied. The surfactant was administered in a dose of 30 mg/kg before of after exposure of animals to X-rays (a dose of 16 cGy). It was found that the combined effect of Tween 80 and the low dose of X-rays caused disturbances in LPO regulatory system. Manifestation of the disturbances depended on the time interval after exposure, the fact whether Tween 80 was administered before or after irradiation, the examined tissue and the parameter studied. The administration of Tween 80 after irradiation intensified the effect of X-rays in more extent than its administration before irradiation.
Shishkina
L N
LN
Emanuel Institute of Biochemical Physics, Russian Academy of Science, Moscow, 117977 Russia.
Kushireva
E V
EV
Smotriaeva
M A
MA
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D004247:DNA / Q000097:blood; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects* / Q000528:radiation effects*; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D051379:Mice; D011136:Polysorbates / Q000494:pharmacology*; D014965:X-Rays
D000975:Antioxidants; D011136:Polysorbates; D004247:DNA