title: Comparative anti-caries effects of tablet and liquid fluorides in cleft children.
abstract: Children with cleft lip and/or palate are at a higher risk for developing caries of the primary incisors compared with non-cleft children. To determine whether fluoride in tablet or liquid form would be more efficacious with children with cleft lip and/or palate, a two-year clinical investigation was conducted to test the anti-caries effects. One-hundred and fifteen cleft children (59 boys and 56 girls) between 22 and 26 months old were randomly selected into control, tablet and liquid fluoride groups. The amount of administered fluoride was 0.25 mg F daily in non-fluoridated Taiwan. Dental examinations were conducted using mirrors and #23 explorers. Caries were assessed using the DMF index in the baseline, first year and second year. The results showed that children in the tablet and liquid groups had a significantly lower DMFT increment than in the control group (p < 0.05). In the DMFS index, children in the liquid group showed a significantly lower caries increment than in the control group (p < 0.01), and children in the tablet group presented a borderline, but non-significant statistical difference when compared with the control group (p = 0.065). No significant statistical difference was found in either DMFT or DMFS between tablet and liquid fluoride administrations (p = 0.521 and p = 0.383, respectively). It is concluded that dietary fluoride supplements in liquid form show efficacy in reducing early childhood caries in the cleft children. Liquid fluoride showed slightly better numerical anti-caries effect than tablet fluoride, which is possibly due to its ease of administration with small children.
authors.affiliation: Department of Orthodontics and Pediatric Dentistry, Chang Gung Memorial Hospital, Kaohsiung Medical Center, Taiwan. Joe0430@ms13.hinet.net
authors.forename: Y T
authors.initials: YT
authors.lastname: Lin
authors.forename: C L
authors.initials: CL
authors.lastname: Tsai
mesh_terms: D000704:Analysis of Variance; D002327:Cariostatic Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D002971:Cleft Lip / Q000150:complications*; D002972:Cleft Palate / Q000150:complications*; D004245:DMF Index; D003731:Dental Caries / Q000150:complications / Q000517:prevention & control*; D019587:Dietary Supplements; D005260:Female; D005459:Fluorides / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008297:Male; D014677:Pharmaceutical Vehicles; D012996:Solutions; D018709:Statistics, Nonparametric; D013607:Tablets
chemical_list: D002327:Cariostatic Agents; D014677:Pharmaceutical Vehicles; D012996:Solutions; D013607:Tablets; D005459:Fluorides