Metallothionein expression and tumor growth in the transplantable pregnancy-independent mouse mammary tumor.
In various human tumors, a metal binding protein, metallothionein (MT) is reported to play an important role in carcinogenesis. In the present preliminary study, MT expression and tumor growth were investigated in transplantable pregnancy-independent mammary tumors (TPIMT) derived from pregnancy-independent mammary tumors (PIMT) in GR/A mice, in order to study the possible role of MT in mammary carcinogenesis. TPIMT as well as PIMT showed MT expression in tumor cells in all of the successive transplantations. A negative correlation was observed between MT expression in transplanted tumor tissues and their growth in the hosts (r=-0.53, p<0.05). The present study indicates that MT is a useful marker of tumor progression in TPIMT.
Yamamura
Y
Y
The United Graduate School of Veterinary Science, Yamaguchi University, Japan.
Tamano
M
M
Iguchi
T
T
Ohta
Y
Y
D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis / Q000096:biosynthesis; D002455:Cell Division / Q000502:physiology; D005260:Female; D006651:Histocytochemistry / Q000662:veterinary; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism* / Q000473:pathology*; D008668:Metallothionein / Q000032:analysis / Q000096:biosynthesis*; D051379:Mice; D009368:Neoplasm Transplantation; D011247:Pregnancy
D014408:Biomarkers, Tumor; D008668:Metallothionein