[Prognostic value of DNA ploidy in prostatic cancer].
OBJECTIVE
To asses the prognostic value of deoxyribonucleic acid (DNA) ploidy in a group of patients with prostate cancer treated with adrogenic blockade.


METHODS
A retrospective study on 136 patients with prostatic cancer having undergone androgenic blockade was carried out. The prognostic influence of age, T and M categories, Gleason score and flow cytometry-determined DNA ploidy from survival analyses. Univariate survival analysis was carried out following Kaplan-Meier's method, while for multivariate survival analysis Cox's proportional hazard model was used.


RESULTS
The univariante analysis showed that T and M categories, Gleason score and DNA ploidy have prognostic value. The Cox's regression analysis identified DNA ploidy, metastasis and Gleason score as independent variables having prognostic potential.


CONCLUSIONS
DNA ploidy has independent prognostic value in prostate cancer treated with androgenic blockade and improves the predictive potential of classical prognostic factors.
Martínez Jabaloyas
J M
JM
Servicio de Urología, Hospital Universitario La Fe, Valencia.
Ruiz Cerdá
J L
JL
Sanz Chinesta
S
S
Jiménez
A
A
Hernández
M
M
Jiménez Cruz
J F
JF
D000230:Adenocarcinoma / Q000737:chemistry / Q000235:genetics*; D000368:Aged; D000369:Aged, 80 and over; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000235:genetics*; D012189:Retrospective Studies
D004273:DNA, Neoplasm