Transferrin C2 variant does not confer a risk for Alzheimer's disease in Koreans.
We analyzed the transferrin (TF) and apolipoprotein E (APOE) genotypes of 164 probable Alzheimer's disease (AD) patients and 239 cognitively normal elderly controls in Koreans. We failed to detect a significant difference in genotypic frequencies and allelic frequencies of the TF polymorphism between the AD group and control group (P>0.1 by Chi square test). The frequency of the TF C2 variant did not differ by the diagnosis when the APOE epsilon4-positive subjects and APOE epsilon4-negative subjects were analyzed separately (P>0.1 by Chi square test). The TF C2 variant did not influence the age-at-onset of AD independently or synergistically with the occurrence of the APOE epsilon4 allele (P>0.1 by ANOVA). The TF C2 variant did not confer a risk for AD in Koreans.
Kim
K W
KW
Department of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, 17 Sangha-ri, Koosung-myun, Yongin, Kyunggi-do, South Korea.
Jhoo
J H
JH
Lee
J H
JH
Lee
D Y
DY
Lee
K U
KU
Youn
J Y
JY
Woo
J I
JI
D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics* / Q000378:metabolism / Q000503:physiopathology; D001057:Apolipoproteins E / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D005260:Female; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007723:Korea; D015810:Linkage Disequilibrium / Q000235:genetics; D008297:Male; D011110:Polymorphism, Genetic / Q000235:genetics*; D012737:Sex Factors; D014168:Transferrin / Q000235:genetics* / Q000378:metabolism
D001057:Apolipoproteins E; D014168:Transferrin