Ventroptin: a BMP-4 antagonist expressed in a double-gradient pattern in the retina.
In the visual system, the establishment of the anteroposterior and dorsoventral axes in the retina and tectum during development is important for topographic retinotectal projection. We identified chick Ventroptin, an antagonist of bone morphogenetic protein 4 (BMP-4), which is mainly expressed in the ventral retina, not only with a ventral high-dorsal low gradient but also with a nasal high-temporal low gradient at later stages. Misexpression of Ventroptin altered expression patterns of several topographic genes in the retina and projection of the retinal axons to the tectum along both axes. Thus, the topographic retinotectal projection appears to be specified by the double-gradient molecule Ventroptin along the two axes.
Sakuta
H
H
Division of Molecular Neurobiology, National Institute for Basic Biology, The Graduate University for Advanced Studies, 38 Nishigonaka, Myodaiji-cho, Okazaki 444-8585, Japan.
Suzuki
R
R
Takahashi
H
H
Kato
A
A
Shintani
T
T
Iemura Si
Yamamoto
T S
TS
Ueno
N
N
Noda
M
M
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D002642:Chick Embryo; D003001:Cloning, Molecular; D018274:Electroporation; D004625:Embryo, Nonmammalian / Q000166:cytology / Q000378:metabolism; D005136:Eye Proteins / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*; D018507:Gene Expression Regulation, Developmental; D015723:Gene Library; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008845:Microinjections; D008969:Molecular Sequence Data; D009024:Morphogenesis; D009419:Nerve Tissue Proteins; D011233:Precipitin Tests; D011485:Protein Binding; D020033:Protein Isoforms / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D012160:Retina / Q000196:embryology* / Q000378:metabolism*; D016415:Sequence Alignment; D020349:Surface Plasmon Resonance; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology / Q000378:metabolism
C525809:BMP4 protein, human; C525810:Bmp4 protein, mouse; D055415:Bone Morphogenetic Protein 4; D019485:Bone Morphogenetic Proteins; C486602:CHRDL1 protein, human; C430597:Chrdl1 protein, mouse; D005136:Eye Proteins; D009419:Nerve Tissue Proteins; D020033:Protein Isoforms; D012333:RNA, Messenger; D029867:Xenopus Proteins; C525812:bmp4 protein, Xenopus