Genomic imprinting: mother maintains methylation marks.
A DNA methyltransferase has been identified that plays a role in maintaining the methylation status of imprinted genes. Interestingly, although expressed in the unfertilised egg, this enzyme functions only during one round of replication in the eight-cell embryo.
Dean
W
W
Developmental Genetics Programme, The Babraham Institute, CB2 4AT, Cambridge, UK.
Ferguson-Smith
A
A
D000818:Animals; D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases / Q000235:genetics / Q000502:physiology*; D019175:DNA Methylation; D004622:Embryo, Mammalian / Q000201:enzymology; D005260:Female; D018392:Genomic Imprinting; D051379:Mice; D018345:Mice, Knockout; D008957:Models, Genetic
D000076123:DNA (Cytosine-5-)-Methyltransferase 1; D004248:DNA (Cytosine-5-)-Methyltransferases