[Selective distribution of IL-1 beta and IL-6 contents in the right and left cortices of Balb/c mice].
The purpose of the present work was to study the different distribution of interleukin-1 beta (IL-1 beta) and interleukin-6 (IL-6) contents in the right and left cortices, which may be related to the differences in immunomodulatory functions between the two cerebral cortices. Samples of tissue homogenate were prepared from the left and right cerebral cortices of the Balb/c mice and IL-1 beta, and IL-6 contents were measured using ELISA kits. Both IL-1 beta (P < 0.01) and IL-6 (P < 0.001) contents of the right cortex were higher than those of the left. After injection of LPS, the IL-6 content of the left cortex increased. No statistically significant difference of IL-1 beta contents was found between the two cerebral cortices, while the IL-6 content of the right cortex was higher than that of the left (P < 0.01), suggesting that some cytokines are probably involved in the differences between the right and left cerebral immunomodulatory functions in mice.
Fu
Q L
QL
Department of Microbiology and Immunology, Medical College, Shantou University, Shantou 515031.
Li
K S
KS
D000818:Animals; D002540:Cerebral Cortex / Q000737:chemistry* / Q000276:immunology* / Q000378:metabolism; D005260:Female; D007375:Interleukin-1 / Q000032:analysis / Q000378:metabolism*; D015850:Interleukin-6 / Q000032:analysis / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D015213:Neuroimmunomodulation
D007375:Interleukin-1; D015850:Interleukin-6