title: Evolving strategies for renoprotection: non-diabetic chronic renal disease.
abstract: Experimental and clinical studies over the past two decades have identified several interventions for slowing the progression of chronic renal disease towards end-stage renal failure. In this paper we review the experimental and clinical evidence in support of dietary protein restriction, angiotensin-converting enzyme inhibitor therapy, control of systemic hypertension, reduction of proteinuria, treatment of hyperlipidemia and smoking cessation. We also consider potential future renoprotective therapies. Finally we propose a comprehensive strategy for achieving maximal renoprotection with available interventions and monitoring.
authors.affiliation: Renal Unit, Nottingham City Hospital, Hucknall Road, Nottingham, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: Taal
authors.forename: B M
authors.initials: BM
authors.lastname: Brenner
mesh_terms: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018753:Diet, Protein-Restricted; D006801:Humans; D006949:Hyperlipidemias / Q000628:therapy; D006973:Hypertension / Q000188:drug therapy; D007676:Kidney Failure, Chronic / Q000209:etiology / Q000517:prevention & control / Q000628:therapy*; D015260:Neprilysin / Q000037:antagonists & inhibitors; D011507:Proteinuria / Q000628:therapy; D016540:Smoking Cessation
chemical_list: D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000893:Anti-Inflammatory Agents; D015260:Neprilysin