Analysis of virus-specific CD4(+) t cells during long-term gammaherpesvirus infection.
Major histocompatibility complex class II-mediated antigen presentation after intranasal infection with murine gammaherpesvirus 68 differs in mediastinal lymph nodes and spleen. Evidence that virus-specific CD4(+) T cells were being stimulated was found as late as 6 to 8 months after infection, and cells specific for the viral gp150(67-83) and ORF11(168-180) peptides were maintained as a fairly stable proportion of the total response.
Flaño
E
E
Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
Woodland
D L
DL
Blackman
M A
MA
Doherty
P C
PC
D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018142:Gammaherpesvirinae; D006566:Herpesviridae Infections / Q000276:immunology*; D007111:Immunity, Cellular; D051379:Mice; D013997:Time Factors
D000956:Antigens, Viral