title: Oxygen effects on glucose measurements with a reference analyzer and three handheld meters.
abstract: Oxygen may affect glucose meter and reference analyzer measurements. We evaluated the effects of changes in blood oxygen tension (Po2) on Accu-Chek Comfort Curve (Roche Diagnostics, Indianapolis, IN), Precision G, (Abbott Laboratories, Bedford, MA) and One Touch II (Lifescan, Milpitas, CA) glucose meter measurements, and on Yellow Springs Instruments (YSI) (Yellow Springs, OH) reference analyzer measurements. Venous blood drawn from healthy volunteers was adjusted to three glucose levels of 80, 200, and 400 mg/dL, each tonometered with six different Po2 levels (40, 80, 160, 240, 320, and 400 torr). To quantitate oxygen effects on reference analyzer measurements, glucose differences between test sample (Po2 changed) and control (Po2 80 torr) were calculated (YSItest-YSIcontrol). The threshold for determination of oxygen effects was +/-2 SD, where 2 SD was fro
authors.affiliation: Department of Medical Pathology, School of Medicine, University of California, Davis 95616, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Tang
authors.forename: R F
authors.initials: RF
authors.lastname: Louie
authors.forename: M
authors.initials: M
authors.lastname: Payes
authors.forename: K C
authors.initials: KC
authors.lastname: Chang
authors.forename: G J
authors.initials: GJ
authors.lastname: Kost
mesh_terms: D001774:Blood Chemical Analysis / Q000295:instrumentation* / Q000379:methods; D001786:Blood Glucose / Q000032:analysis*; D016638:Critical Illness; D006801:Humans; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D019095:Point-of-Care Systems / Q000592:standards*; D012016:Reference Values; D015203:Reproducibility of Results
chemical_list: D001786:Blood Glucose; D010100:Oxygen