Effect of cyclosporin on uropathogenic Escherichia coli adherence to human endothelial cells.
The effect of cyclosporin A on the adherence of Escherichia coli strains to human umbilical vein endothelial cells was studied. Compared with the controls, bacterial adherence significantly increased following preincubation of the cells with cyclosporin A at 50 mg/l and more significantly, to cells preincubated with cyclosporin A at 100-200 mg/l. The results showed that cyclosporin A use may be accompanied by an increased bacterial adherence to host cells in vivo. This effect was achieved using a wide range of therapeutic doses.
Szkaradkiewicz
A
A
Institute of Microbiology and Infectious Diseases, Karol Marcinkowski University of Medical Sciences in Poznan, Wieniawskiego 3, 61-712, Poznan, Poland.
Wal
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D000328:Adult; D001422:Bacterial Adhesion / Q000187:drug effects*; D016572:Cyclosporine / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000382:microbiology*; D004926:Escherichia coli / Q000187:drug effects / Q000472:pathogenicity / Q000502:physiology*; D004927:Escherichia coli Infections / Q000382:microbiology; D006801:Humans; D014552:Urinary Tract Infections / Q000382:microbiology
D016572:Cyclosporine