Microtubule motors, phosphorylation and axonal transport of neurofilaments.
The recent demonstration that the axonal transport motors kinesin and dynein participate in axonal transport of neurofilaments (NFs), and that the association of NFs with these motors is regulated by phosphorylation provides new insight into several aspects of axonal transport and NF biology. This review juxtaposes older and more recent findings on NF dynamics, and speculates on the organization of axonal NFs as suggested by real-time analyses of NF transport.
Shea
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Center for Cellular Neurobiology and Neurodegeneration Research, Department of Biological Sciences, University of Massachusetts, Lowell, MA 01854, USA. thomas.shea@uml.edu
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D004398:Dyneins / Q000378:metabolism; D016547:Kinesins / Q000378:metabolism; D008856:Microscopy, Fluorescence; D008870:Microtubules / Q000378:metabolism*; D020409:Molecular Motor Proteins / Q000378:metabolism*; D019636:Neurodegenerative Diseases / Q000378:metabolism; D016900:Neurofilament Proteins / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000166:cytology / Q000378:metabolism*; D010766:Phosphorylation; D021122:Protein Subunits; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D012160:Retina / Q000378:metabolism
D020409:Molecular Motor Proteins; D016900:Neurofilament Proteins; D021122:Protein Subunits; D011993:Recombinant Fusion Proteins; D004398:Dyneins; D016547:Kinesins