[Effect of endogenous nitric oxide on the nerve-muscle synapse function].
The nitric oxide (NO) precursor L-arginine was found to decrease the amplitude and the quantum content of the EPPs and to increase the amplitude of the AP third deflection in the frog neuromuscular junction of the m. cutaneous pectoris preparation. Inhibitor of the NO synthase NG-nitro-L-arginine methylester exerted opposite effects. The data obtained suggest that endogenous NO is produced in the neuromuscular synapse area and can modify the work of potassium ion channels.
Zefirov
A L
AL
Kazan State Medical University, Kazan, Butlerov St., 49, 420012.
Khaliullina
R R
RR
Anuchin
A A
AA
Iakovlev
A V
AV
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D004558:Electric Stimulation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D009569:Nitric Oxide / Q000096:biosynthesis*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D019335:Nitroarginine / Q000494:pharmacology; D011895:Rana ridibunda
D004791:Enzyme Inhibitors; D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase