Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors.
[reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.
Kim
B M
BM
Center for Molecular Catalysis, School of Chemistry & Molecular Engineering, Seoul National University, Seoul, 151-747, Korea. kimbm@snu.ac.kr
Bae
S J
SJ
So
S M
SM
Yoo
H T
HT
Chang
S K
SK
Lee
J H
JH
Kang
J
J
D001388:Aziridines / Q000138:chemical synthesis*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry
D001388:Aziridines; D017320:HIV Protease Inhibitors; D013644:Tartrates; C029768:tartaric acid