Ypt and Rab GTPases: insight into functions through novel interactions.
Ypt/Rab GTPases are key regulators of vesicular transport in eukaryotic cells. During the past two years, a number of new Ypt/Rab-interacting proteins have been identified and shown to serve as either upstream regulators or downstream effectors. Proteins that interact with these regulators and effectors of Ypt/Rabs have also been identified, and together they provide new insights into Ypt/Rab mechanisms of action. The picture that emerges from these studies suggests that Ypt/Rabs function in multiple and diverse aspects of vesicular transport. In addition, not only are Ypt/Rabs highly conserved, but their functions and interactions are as well. Interestingly, crosstalk among Ypt/Rabs and between Ypt/Rabs and other signaling factors, suggest the possibility of coordination of the individual vesicular transport steps and of the protein transport machinery with other cellular processes.
Segev
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Department of Biological Sciences, Laboratory for Molecular Biology, University of Illinois at Chicago, 60607, USA. nava@uic.edu
D000818:Animals; D005656:Fungal Proteins / Q000378:metabolism / Q000502:physiology; D020690:GTPase-Activating Proteins / Q000502:physiology; D020662:Guanine Nucleotide Exchange Factors / Q000502:physiology; D008954:Models, Biological; D021381:Protein Transport; D022161:Transport Vesicles / Q000378:metabolism; D020691:rab GTP-Binding Proteins / Q000378:metabolism* / Q000502:physiology*
D005656:Fungal Proteins; D020690:GTPase-Activating Proteins; D020662:Guanine Nucleotide Exchange Factors; D020691:rab GTP-Binding Proteins