Antibodies against Chlamydia pneumoniae predict the need for elective surgical intervention on small abdominal aortic aneurysms.
OBJECTIVE
to compare the ability of two independent Chlamydia pneumoniae antibody tests to predict need for small abdominal aortic aneurysm (AAA) repair.


METHODS
annual scans were offered to 149 screening diagnosed small AAA (<5 cm). Serum samples were collected for measuring IgA and IgG-antibodies to C. pneumoniae by microimmunofluorescence (MIF) test and the new ELISA (Labsystems).


RESULTS
a significant concordance was found between MIF and ELISA titres with Kappa values of 0.29 for S-IgA and 0.42 for S-IgG. IgG antibodies measured by ELISA were most predictive for cases expanding operation recommendable sizes with a sensitivity and specificity of 80% and 66%, respectively.


CONCLUSIONS
the simpler EIA has a high correlation with the MIF test and both were predictive for the natural history of AAA. Chlamydia antibody test may be used to identify individuals who might benefit from follow-up and anti-chlamydia treatment.
Vammen
S
S
Department of Vascular Surgery, Viborg Hospital, Denmark.
Lindholt
J S
JS
Andersen
P L
PL
Henneberg
E W
EW
Østergaard
L
L
D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D017544:Aortic Aneurysm, Abdominal / Q000276:immunology / Q000601:surgery*; D001161:Arteriosclerosis / Q000276:immunology / Q000601:surgery*; D002690:Chlamydia Infections / Q000276:immunology / Q000601:surgery*; D016993:Chlamydophila pneumoniae / Q000276:immunology*; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests
D000907:Antibodies, Bacterial