Mode of perturbation of Asahi fibrin assembly by the extra oligosaccharides.
Steric hindrance by the backbone of extra oligosaccharides at gamma-Asn 308 may cause the repulsive force to widen the junction at the D:D interface, and thus, interfere with the longitudinal elongation and lateral association of protofibrils.
Sugo
T
T
Division of Cell and Molecular Medicine, Center for Molecular Medicine, Jichi Medical School, Yakushiji 3311-1, Tochigi, 329-0498, Japan. sugosan@jichi.ac.jp
Sekine
O
O
Nakamikawa
C
C
Endo
H
H
Arocha-Piñango
C L
CL
Matsuda
M
M
D005337:Fibrin / Q000737:chemistry* / Q000648:ultrastructure; D015241:Fibrinogens, Abnormal / Q000737:chemistry*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009844:Oligosaccharides / Q000737:chemistry*
D015241:Fibrinogens, Abnormal; D009844:Oligosaccharides; D005337:Fibrin