Mechanisms by which metals promote events connected to neurodegenerative diseases.
Although the exact causative phenomenon responsible for the onset and progression of neurodegenerative disorders is at present unresolved, there are some clues as to the mechanisms underlying these chronic diseases. This review addresses mechanisms by which endogenous or environmental factors, through interaction with redox active metals, may initiate a common cascade of events terminating in neurodegeneration.
Campbell
A
A
Department of Community and Environmental Medicine, University of California, Irvine, Irvine, CA 92697-1825, USA. aghadimi@uci.edu
Smith
M A
MA
Sayre
L M
LM
Bondy
S C
SC
Perry
G
G
D000375:Aging / Q000378:metabolism / Q000473:pathology; D000818:Animals; D004660:Encephalitis / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008670:Metals / Q000633:toxicity*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000378:metabolism; D019636:Neurodegenerative Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D017382:Reactive Oxygen Species / Q000378:metabolism*; D014131:Trace Elements / Q000633:toxicity*
D008670:Metals; D009419:Nerve Tissue Proteins; D017382:Reactive Oxygen Species; D014131:Trace Elements