title: High risk human papillomavirus in oral squamous carcinoma: evidence of risk factors in a Venezuelan rural population. Preliminary report.
abstract: In a search for the presence of human papillomavirus (HPV) and some etiologic cofactors in oral squamous cell carcinoma (OSCC), 50 women diagnosed as OSCC were analyzed by a multiplex polymerase chain reaction (PCR) assay specific for HPV types 6, 11, 16, and 18. This study revealed that 60% (30/50) of the OSCC patients were positive for HPV-DNA sequences. This group was analyzed according to smoking, alcohol consumption, number of pregnancies, poor oral health and low social economic status. The current results indicate an increased incidence of HPV malignant types in the oral cavity in women with OSCC. Also, they support a multifactorial model of oral cancer causation.
authors.affiliation: Centro de Investigaciones Odontológicas, Facultad de Odontologia, Universidad de los Andes, Mérida, Venezuela. premoli@ing.ula.ve
authors.forename: G
authors.initials: G
authors.lastname: Premoli-De-Percoco
authors.forename: J L
authors.initials: JL
authors.lastname: Ramirez
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking / Q000009:adverse effects; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D016009:Chi-Square Distribution; D003043:Cocarcinogenesis; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000821:virology*; D009752:Nutritional Status; D009909:Oral Health; D027383:Papillomaviridae / Q000145:classification*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D010298:Parity; D016133:Polymerase Chain Reaction; D017584:Reproductive History; D012307:Risk Factors; D012423:Rural Health; D012907:Smoking / Q000009:adverse effects; D012923:Social Class; D013223:Statistics as Topic; D014412:Tumor Virus Infections / Q000175:diagnosis*; D014687:Venezuela
chemical_list: D004279:DNA, Viral