Mollusk-derived growth factor: cloning and developmental expression in the central nervous system and reproductive tract of Aplysia.
We have isolated and characterized an atrial gland cDNA that corrects the previously reported sequence for Aplysia atrial gland granule-specific antigen (AGSA), a glycoprotein of unknown function. We designated the protein mollusk-derived growth factor (MDGF) to distinguish the revised sequence from AGSA and to emphasize its similarity to an insect-derived growth factor (IDGF). We describe MDGF mRNA expression that suggests a possible role during embryonic development and CNS injury repair.
Akalal
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DB
Marine Biomedical Institute and Department of Anatomy and Neurosciences, University of Texas Medical Branch, Medical Research Building, Galveston, TX 77555-1043, USA. dakalal@utmb.edu
Nagle
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D000243:Adenosine Deaminase / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001048:Aplysia / Q000235:genetics*; D001483:Base Sequence; D002490:Central Nervous System / Q000502:physiology; D003001:Cloning, Molecular; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006066:Gonads / Q000502:physiology; D006133:Growth Substances / Q000235:genetics / Q000378:metabolism*; D007288:Inosine / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis
D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger; D007288:Inosine; D000243:Adenosine Deaminase; C435026:mollusk-derived growth factor