Biodegradable implants in neurosurgery.
BACKGROUND
Biodegradable materials have been used for osteosynthesis by orthopedic surgeons and craniomaxillofacial surgeons for many years. However, such materials are not yet widely used by neurosurgeons despite potential applications. This prospective study was undertaken to evaluate potential applications of biodegradable materials in neurosurgical interventions.


METHODS
A total of 104 4-hole plates and 228 screws consisting of copolymer of poly-70 L/30 D,L-lactide were inserted for fixation of bone flaps in 8 patients and for reinsertion of laminoplasties at 28 levels in 16. The craniotomies were performed for removal of a brain tumour in 4 cases, for surgical management of an aneurysm or cerebral AVM in 2, and for treatment of craniocerebral trauma in another 2. Laminoplasties were performed at 25 levels for intraspinal hemangioblastomas in 15 patients. One patient with an ependymoma underwent 3-level laminoplasty.


RESULTS
One patient with severe head injury in whom the bone flap was re-implanted several months following the craniectomy, developed an aseptic necrosis of the bone flap, which had to be removed. Implant rejection was not observed. One patient suffered from mild local pain in the area of a biodegradeable screw in the frontal region following removal of a sphenoid wing meningeoma. None of the patients with laminoplasty showed signs of functional instability or spinal cord compression. Implant rejection was not observed. No delayed healing or infection occurred. Healing was not delayed and no infections occurred.


CONCLUSIONS
The results encourage further use of biodegradable materials for the described applications. Additional studies will be performed to investigate the usefulness of biodegradable devices in neurosurgery and to obtain long-term results.
Stendel
R
R
Department of Neurosurgery, Benjamin Franklin Medical Center, Free University of Berlin, Germany.
Krischek
B
B
Pietilä
T A
TA
D020341:Absorbable Implants; D001860:Bone Plates; D001863:Bone Screws; D003399:Craniotomy / Q000295:instrumentation*; D020878:Device Removal; D006801:Humans; D007796:Laminectomy / Q000295:instrumentation*; D008279:Magnetic Resonance Imaging; D011091:Polyesters; D011183:Postoperative Complications / Q000175:diagnosis / Q000601:surgery; D011446:Prospective Studies; D012086:Reoperation
D011091:Polyesters; C033616:poly(lactide)