In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines.
The alkaloidic fraction of the methanol extract of Peganum harmala seeds was tested in vitro on three tumoral cell-lines: UCP-Med and Med-mek carcinoma, and UCP-Med sarcoma. Proliferation was significantly reduced at all tested concentrations (20-120 micrograms/ml) during the first 24 h of contact. A cell lysis effect occurred after 24 h and increased thereafter to complete cell death within 48-72 h, depending on tested concentration.
Lamchouri
F
F
Laboratoire de Pharmacologie et Toxicologie, Faculté de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco.
Settaf
A
A
Cherrah
Y
Y
Hassar
M
M
Zemzami
M
M
Atif
N
N
Nadori
E B
EB
Zaid
A
A
Lyoussi
B
B
D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales; D012639:Seeds; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts