Cholecystokinin and thermoregulation--a minireview.
Thermoregulatory effects of cholecystokinin (CCK) peptides are reviewed with special emphasis on two types of responses, that is hypothermia or hyperthermia. In rodents exposed to cold a dose-dependent hypothermia has been observed on peripheral injection of CCK probably acting on CCKA receptors. Central microinjection of CCK in rats induced a thermogenic response that could be attenuated by CCKB receptor antagonists, but some authors observed a hypothermia. It is suggested that neuronal CCK may have a specific role in the development of hyperthermia, and endogenous CCK-ergic mechanisms could contribute to the mediation of fever. Possible connections between thermoregulatory and other autonomic functional changes induced by CCK are discussed.
Szelényi
Z
Z
Department of Pathophysiology, Faculty of Medicine, University of Pécs, 7624 Pécs, Hungary. szelenyi@apacs.pote.hu
D000818:Animals; D002766:Cholecystokinin / Q000737:chemistry* / Q000502:physiology*; D003080:Cold Temperature; D005334:Fever; D007035:Hypothermia; D010455:Peptides / Q000737:chemistry; D051381:Rats; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin / Q000378:metabolism; D013696:Temperature
D010455:Peptides; D043886:Receptor, Cholecystokinin A; D043887:Receptor, Cholecystokinin B; D011949:Receptors, Cholecystokinin; D002766:Cholecystokinin