Analysis of alpha-2-macroglobulin-2 allele as a risk factor in Alzheimer's disease.
A correlation between a 5-nucleotide deletion polymorphism in the A2M gene and an enhanced risk of developing Alzheimer's disease (AD) was reported. We studied this polymorphism in sporadic AD patients and patients with frontotemporal dementia (FTD) by using an electrophoretical separation of PCR products on a Metaphor gel. Our results did not show any significant difference between A2M-2 allelic frequency (p = 0.89) or genotype frequency (p = 0.97) in the two different clinical series and in control subjects. The frequencies were not significantly different after stratification by APOE epsilon4 status.
Nicosia
F
F
Neurobiology Laboratory, Alzheimer's Unit, IRCCS Centro San Giovanni di Dio-Fatebenefratelli, Via Pilastroni 4, I-25123 Brescia, Italy.
Alberici
A
A
Benussi
L
L
Gasparini
L
L
Ghidoni
R
R
Mazzoli
F
F
Zanetti
O
O
Frisoni
G B
GB
Geroldi
C
C
Binetti
G
G
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000235:genetics*; D003704:Dementia / Q000235:genetics*; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency / Q000235:genetics; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D012307:Risk Factors; D000511:alpha-Macroglobulins / Q000235:genetics*
D000511:alpha-Macroglobulins