A new strategy for the stereoselective introduction of steroid side chain via alpha-alkoxy vinyl cuprates: total synthesis of a highly potent antitumor natural product OSW-1.
Yu
W
W
Division of Medicinal and Natural Products Chemistry College of Pharmacy, The University of Iowa Iowa City, Iowa 52242, USA.
Jin
Z
Z
D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D002783:Cholestenones; D003300:Copper / Q000737:chemistry*; D009942:Organometallic Compounds / Q000737:chemistry*; D012503:Saponins / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013256:Steroids / Q000737:chemistry*; D014753:Vinyl Compounds / Q000737:chemistry
D000972:Antineoplastic Agents, Phytogenic; D002783:Cholestenones; D009942:Organometallic Compounds; D012503:Saponins; D013256:Steroids; D014753:Vinyl Compounds; C106408:OSW 1; D003300:Copper