title: A cross-sectional study of SEN virus in liver transplant recipients.
abstract: A new DNA virus, referred to as SEN virus (SEN V), has been isolated and is associated with blood-product transfusion and possibly Non A to Non E hepatitis. We performed a cross-sectional analysis of SEN V in liver transplant recipients at our center. Polymerase chain reaction was used to test for 2 genotypes of SEN V (SEN V:C/H and SEN V:D) in 58 unselected patients. Comparisons were made between SEN V--positive and SEN V--negative groups in terms of age, time posttransplantation, indications for transplantation, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels, and cytomegalovirus and Epstein-Barr virus status. Thirty of 58 transplant recipients (51.7%) were SEN V positive; 15.5% were positive for SEN V:C/H, 24.1% for SEN:D, and 12.1% for both strains. No significant differences were found based on primary indication for transplantation, including hepatitis C virus (HCV). Of the 14 of 21 patients with HCV seropositivity and HCV reinfection, 79% were positive for SEN V (P =.02). There was no difference in the proportion of patients with abnormal serum ALT and/or AST levels. A trend for the SEN V--positive group to have a greater mean ALT level (82 v 41 U/L; P =.067) was attributable to the subgroup with HCV recurrence because there was no difference in mean ALT levels (34.9 v 34.5 U/L; P =.968) in non--HCV-infected transplant recipients. Even in the subgroup (n = 14) with recurrent HCV, there was no statistically significant difference in mean ALT levels (140 v 105 U/L; P =.665). Age and cytomegalovirus or Epstein-Barr virus status were not significantly different between the 2 groups, but a significant difference in posttransplantation time was noted (16.8 v 32 months; P =.021). We conclude that SEN V is common among liver transplant recipients but does not appear to cause graft dysfunction as an isolated agent. There is a suggestion that SEN V may be associated with HCV recurrence, but we did not detect biochemical differences attributable to SEN V.
authors.affiliation: Department of Medicine, University of British Columbia, British Columbia Transplant Society, Vancouver, BC.
authors.forename: E M
authors.initials: EM
authors.lastname: Yoshida
authors.forename: A K
authors.initials: AK
authors.lastname: Buczkowski
authors.forename: A
authors.initials: A
authors.lastname: Giulivi
authors.forename: S
authors.initials: S
authors.lastname: Zou
authors.forename: L A
authors.initials: LA
authors.lastname: Forrester
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D003430:Cross-Sectional Studies; D004267:DNA Viruses / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D006518:Hepatitis Viruses / Q000235:genetics / Q000302:isolation & purification* / Q000472:pathogenicity; D006525:Hepatitis, Viral, Human / Q000209:etiology / Q000635:transmission; D006801:Humans; D016031:Liver Transplantation / Q000009:adverse effects*; D065227:Transfusion Reaction; D014774:Virulence
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase