Immediate post-transplant nephrosis in a patient with congenital nephrotic syndrome.
A 19-month-old girl with congenital nephrotic syndrome of the Finnish type underwent a living-related renal transplant; 24 h after transplantation she became massively nephrotic. She did not respond to steroids, plasmapheresis, and high-dose cyclosporine. A month later, a renal biopsy showed only glomerular foot process effacement. She was treated with high-dose methylprednisolone pulses and oral cyclophosphamide. She rapidly went into complete remission with no further relapses. Graft function has been stable 2 years after transplantation.
Barayan
S S
SS
Division of Pediatric Nephrology, UCLA Children's Hospital, Los Angeles, CA 90095-1752, USA.
Al-Akash
S I
SI
Malekzadeh
M
M
Marik
J L
JL
Cohen
A H
AH
Ettenger
R B
RB
Yadin
O
O
D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use; D009401:Nephrosis / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000151:congenital / Q000601:surgery*; D012709:Serum Albumin / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D012709:Serum Albumin; D003520:Cyclophosphamide; D008775:Methylprednisolone