title: [Impact of menopause hormone replacement therapy on screening mammography reading].
abstract: OBJECTIVE
  To assess difficulties in reading screening mammographies related to hormone replacement therapy (HRT) in the setting of a breast cancer screening program. Disagreement between two readers is used as the assessment criterion.
  
  
  METHODS
  The study population consisted of all women participating in the ADEMAS breast cancer screening program in Bas-Rhin (France). Agreement between the two radiologists was considered when the same global conclusion (call-back or not of the women for further examination) or the same conclusion for each of the nine possible lesions was observed.
  
  
  RESULTS
  HRT is associated with a higher risk of disagreement between the two radiologists on global conclusion and on opacities. Conversely, disagreement risk is lowered for microcalcifications (whether benign or malignant) for HRT users.
  
  
  CONCLUSIONS
  HRT is associated with a higher risk of disagreement on global conclusion. This has an impact on whether the women should be called-back or not according to reading of breast cancer screening program mammographies.
authors.affiliation: Laboratoire d'Epidémiologie et de Santé Publique, Faculté de Médecine, 4, rue Kirschleger, 67091 Strasbourg Cedex.
authors.forename: N E
authors.initials: NE
authors.lastname: Meye
authors.forename: P
authors.initials: P
authors.lastname: Schaffer
authors.forename: G
authors.initials: G
authors.lastname: Hédelin
authors.forename: C
authors.initials: C
authors.lastname: Guldenfels
authors.forename: B
authors.initials: B
authors.lastname: Gairard
mesh_terms: D000368:Aged; D001943:Breast Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging*; D015914:Estrogen Replacement Therapy; D005260:Female; D005602:France; D006801:Humans; D016015:Logistic Models; D008327:Mammography / Q000592:standards*; D008403:Mass Screening / Q000379:methods / Q000592:standards*; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D015588:Observer Variation; D012307:Risk Factors