title: Phenolic constituents of Ononis vaginalis roots.
abstract: The ether soluble fraction of the roots of Ononis vaginalis Vahl. Symb. afforded three new compounds: 3-hydroxy-4,9-dimethoxycoumestan, maginaldehyde [2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxy-3-benzofuran-carboxaldehyde] and 5,7,4'-trihydroxy-4-styrylcoumarin. In addition, four known pterocarpans; 3,4,9-trimethoxypterocarpan, maackiain, medicarpin and trifolirhizin were also isolated. The styrylcoumarin derivative showed significant antiviral activity against Herpes simplex type 1 and weak cytotoxicity.
authors.forename: M S
authors.initials: MS
authors.lastname: Abdel-Kader
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification; D003374:Coumarins / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008519:Medicine, Traditional; D015394:Molecular Structure; D010636:Phenols / Q000737:chemistry*; D010936:Plant Extracts / Q000737:chemistry*; D018517:Plant Roots / Q000737:chemistry*; D036343:Pterocarpans; D013055:Spectrophotometry, Infrared; D000094162:Phytoalexins
chemical_list: D000998:Antiviral Agents; D001572:Benzofurans; D001578:Benzopyrans; D003374:Coumarins; D010636:Phenols; D010936:Plant Extracts; D036343:Pterocarpans; C431504:3-hydroxy-4,9-dimethoxycoumestan; C431506:5,7,4'-trihydroxy-4-styrylcoumarin; C431505:maginaldehyde(2-(4-hydroxy-2-methoxyphenyl)-5,6-dimethoxy-3-benzofurancarboxaldehyde); C047353:medicarpin; D000094162:Phytoalexins; C001449:inermin