Migration and differentiation of Nkx-2.2+ oligodendrocyte progenitors in embryonic chicken retina.
During early neural development, the Nkx-2.2 homeobox gene is initially induced in the ventral ventricular zone of the central nervous system (CNS). At later stages, Nkx-2.2+ cells migrate away into the surrounding regions and co-express several oligodendrocyte marker genes. Here we report that Nkx-2.2+ cells also migrate into the avian retina from the optic nerve. These Nkx-2.2+ cells are specifically labeled by the early oligodendrocyte markers PDGFR alpha, O4 and GalC, but not the microglial marker QH1 or neuron-specific marker MAP-2. These observations provide further evidence that Nkx-2.2 is selectively expressed in migratory oligodendrocyte progenitor cells and that retina oligodendrocytes originate from the ventral diencephalon.
Fu
H
H
Department of Anatomical Sciences and Neurobiology, School of Medicine, University of Louisville, Louisville, KY 40292, USA.
Qiu
M
M
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D002642:Chick Embryo; D002645:Chickens; D018507:Gene Expression Regulation, Developmental; D000090322:Homeobox Protein Nkx-2.2; D018398:Homeodomain Proteins / Q000235:genetics*; D009836:Oligodendroglia / Q000166:cytology* / Q000502:physiology; D012333:RNA, Messenger / Q000032:analysis; D012160:Retina / Q000166:cytology* / Q000196:embryology*; D013234:Stem Cells / Q000166:cytology* / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics*; D029961:Zebrafish Proteins
D000090322:Homeobox Protein Nkx-2.2; D018398:Homeodomain Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; D029961:Zebrafish Proteins