TmDOTA-: a sensitive probe for MR thermometry in vivo.
The lanthanide complex, thulium 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (TmDOTA-), has been investigated as an agent for MR thermometry in vivo. The chemical shifts of the TmDOTA- protons were highly sensitive to temperature at a clinically relevant field strength, yet insensitive to pH and the presence of Ca2+. Given the excellent stability of lanthanide-DOTA complexes and high thermal sensitivity, TmDOTA- is expected to be a good candidate for MR thermometry in vivo.
Zuo
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CS
Department of Radiology, Beth Israel Deaconess Medical Center, One Deaconess Road, Boston, Massachusetts 02215, USA. czuo@caregroup.harvard.edu
Mahmood
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A
Sherry
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D000818:Animals; D002118:Calcium / Q000737:chemistry; D002614:Chelating Agents / Q000737:chemistry; D006573:Heterocyclic Compounds, 1-Ring / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D008953:Models, Anatomic; D011522:Protons; D051381:Rats; D013696:Temperature
D002614:Chelating Agents; D006573:Heterocyclic Compounds, 1-Ring; D011522:Protons; C071349:1,4,7,10-tetraazacyclododecane- 1,4,7,10-tetraacetic acid; D002118:Calcium