title: Early left periventricular brain lesions induce right hemispheric organization of speech.
abstract: Right-hemispheric organization of speech has been observed following early left-sided brain lesions involving the language cortex. The authors studied speech organization in hemiparetic patients with pre- and perinatally acquired lesions in the left periventricular white matter using fMRI, and found that right-hemisphere activation correlated with left facial motor tract involvement. This suggests that the impairment of speech motor output from the left hemisphere plays an important role in this alteration of language representation.
authors.affiliation: Department of Neuroradiology, Radiological Clinic, Children's Hospital, University of Tübingen, Germany. martin.staudt@med.uni-tuebingen.de
authors.forename: M
authors.initials: M
authors.lastname: Staudt
authors.forename: W
authors.initials: W
authors.lastname: Grodd
authors.forename: G
authors.initials: G
authors.lastname: Niemann
authors.forename: D
authors.initials: D
authors.lastname: Wildgruber
authors.forename: M
authors.initials: M
authors.lastname: Erb
authors.forename: I
authors.initials: I
authors.lastname: Krägeloh-Mann
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000473:pathology*; D002552:Cerebral Ventricles; D004292:Dominance, Cerebral; D005260:Female; D006429:Hemiplegia / Q000151:congenital / Q000175:diagnosis* / Q000523:psychology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012016:Reference Values; D013060:Speech / Q000502:physiology*