New sources and antifungal activity of sesquiterpene lactones.
In the search for new sources of sesquiterpene lactones, six Centaurea species have been analyzed. The activity against the fungus Cunninghamella echinulata of (+)-cnicin (1) and (+)-salonitenolide (2), isolated from the Centaurea plants, as well as that of (+)-costunolide (3), (-)-dehydrocostuslactone (4), (-)-lychnopholide (5) and (-)-eremantholide C (6), has been evaluated. Compounds 3 and 4 showed noticeable EC50 values, whilst more polar lactones were inactive. These results suggest that a relatively low polarity is one of the molecular requirements for the antifungal activity of sesquiterpene lactones.
Barrero
A F
AF
Departamento de Qumica Orgnica, Instituto de Biotecnologa, Facultad de Ciencias, Campus Fuentenueva s/n, 18071 Granada, Spain. afbarre@goliat.ugr.es
Oltra
J E
JE
Alvarez
M
M
Raslan
D S
DS
Saúde
D A
DA
Akssira
M
M
D000935:Antifungal Agents / Q000494:pharmacology*; D019659:Asteraceae; D020093:Cunninghamella / Q000187:drug effects*; D006801:Humans; D007783:Lactones / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D012717:Sesquiterpenes / Q000494:pharmacology*
D000935:Antifungal Agents; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes