In vitro and In vivo inhibition of LPS-stimulated tumor necrosis factor-alpha secretion by the gallotannin beta-D-pentagalloylglucose.
The naturally occurring gallotannin beta-D-pentagalloylglucose (beta-PGG) decreases tumor necrosis factor-alpha (TNF-alpha) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at approximately 5 microM concentration. A qualitatively similar but less pronounced effect ( approximately 50% decrease) was observed in the serum of rats dosed with both LPS and beta-PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-alpha.
Feldman
K S
KS
Department of Chemistry, The Pennsylvania State University, University Park, 16802, PA, USA. ksf@chem.psu.edu
Sahasrabudhe
K
K
Lawlor
M D
MD
Wilson
S L
SL
Lang
C H
CH
Scheuchenzuber
W J
WJ
D000818:Animals; D001685:Biological Factors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D047348:Hydrolyzable Tannins / Q000031:analogs & derivatives / Q000494:pharmacology*; D007375:Interleukin-1 / Q000819:agonists* / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
D001685:Biological Factors; D047348:Hydrolyzable Tannins; D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C435084:pentagalloylglucose