[Drug and gene delivery using electrotransfer].
The use of a low intensity current (iontophoresis) and high voltage pulses (electroporation which permeabilizes lipid bilayers) has a potential for the administration of conventional and biotechnology-produced drugs. Iontophoresis and electroporation enhance transdermal delivery of drugs, including peptides and oligonucleotides. Electrochemotherapy, i.e., combination of a systemic or local delivery of a non-permeant cytostatic drug with electroporation, kills locally tumor cells. Recently, it has been shown that the local injection of a plasmid before electroporation increases significantly gene transfection. Hence, electrotransfer is a promising alternative for drug and gene delivery.
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Université catholique de Louvain, Unité de pharmacie galénique, Avenue Mounier, 73 UCL 7320, B 1200 Bruxelles.
D000818:Animals; D004247:DNA / Q000235:genetics; D016503:Drug Delivery Systems; D018274:Electroporation; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D007478:Iontophoresis
D004247:DNA