A novel application of NMR microscopy: measurement of water diffusion inside bioadhesive bonds.
The self-diffusion coefficient of water (D) inside bioadhesive bonds formed by dry and prehydrated hydrophilic matrices has been spatially resolved using nuclear magnetic resonance (NMR) microscopy. One-dimensional profiles showing the variation of D inside bioadhesive bonds were calculated from nine diffusion-weighted profiles obtained immediately after bond formation and every 5 min for 30 min. The resulting data indicated that the hydration state of a hydrophilic matrix can significantly and dramatically influence the dynamics of water movement inside a bioadhesive bond.
Marshall
P
P
Institute of Pharmaceutical Sciences, University of Nottingham, NG7 2RD, Nottingham, UK. paul.marshall@reckittbenckiser.com
Snaar
J E
JE
Ng
Y L
YL
Bowtell
R W
RW
Hampson
F C
FC
Dettmar
P W
PW
Melia
C D
CD
D003681:Dehydration; D004058:Diffusion; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009077:Mucins / Q000737:chemistry; D012212:Rheology; D014867:Water
D009077:Mucins; D014867:Water