Study of drug release from pellets coated with Surelease containing hydroxypropylmethylcellulose.
The release of metoclopramide hydrochloride (a very water soluble cationic drug) and diclofenac sodium (a sparingly soluble anionic drug) from pellets coated with Surelease containing hydroxypropylmethylcellulose (HPMC) at different coating loads was investigated. The release rates of either drug at each coating composition decreased as the coating load increased. Inclusion of HPMC E15 increased the release rates of both drugs compared to pellets coated only with Surelease. This was thought to be due to the leakage of the soluble part of the film (HPMC E15) during dissolution, which left pores for drug release. The Surelease:HPMC E15 ratio had a major role in the release rates of drugs. Addition of HPMC E15 into Surelease did not change the release mechanism for metoclopramide hydrochloride (the mean value of n approximately 0.57) from that of Surelease alone, and diffusion remained the main mechanism controlling the release. However, the release exponent (approximately 1.28) increased for diclofenac sodium on addition of HPMC E15, indicating a dissolution-controlled mechanism. Despite its lower water solubility, diclofenac sodium was released slightly faster than metoclopramide hydrochloride from pellets coated with Surelease containing HPMC E15 at equivalent coating loads.
Sadeghi
F
F
School of Pharmacy and Chemistry, Liverpool John Moores University, UK. asiahboomi@colorcon.co.uk
Ford
J L
JL
Rubinstein
M H
MH
Rajabi-Siahboomi
A R
AR
D000465:Algorithms; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry; D002482:Cellulose / Q000031:analogs & derivatives / Q000737:chemistry*; D003692:Delayed-Action Preparations / Q000737:chemistry; D004008:Diclofenac / Q000737:chemistry; D018492:Dopamine Antagonists / Q000737:chemistry*; D016503:Drug Delivery Systems; D015195:Drug Design; D007785:Lactose / Q000031:analogs & derivatives* / Q000737:chemistry*; D008747:Methylcellulose / Q000031:analogs & derivatives* / Q000737:chemistry*; D008787:Metoclopramide / Q000737:chemistry*; D010078:Oxazines; D010539:Permeability; D012597:Sclerosing Solutions / Q000737:chemistry*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003692:Delayed-Action Preparations; D018492:Dopamine Antagonists; D010078:Oxazines; D012597:Sclerosing Solutions; D004008:Diclofenac; C013517:ethyl cellulose; D002482:Cellulose; D008747:Methylcellulose; C071191:MK 458; D007785:Lactose; D008787:Metoclopramide