title: Molecular structure of tight junctions and their role in epithelial transport.
abstract: Tight junctions create a paracellular barrier with physiological properties that differ among epithelia. Among these differences are electrical resistance and discrimination for solute size and charge. Emerging evidence suggests that a large family of transmembrane proteins called the claudins create these variable properties.
authors.affiliation: Yale School of Medicine, New Haven, Connecticut 06520-8019, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Anderson
mesh_terms: D000818:Animals; D001692:Biological Transport / Q000502:physiology; D004847:Epithelial Cells / Q000378:metabolism*; D008565:Membrane Proteins / Q000502:physiology*; D062793:Occludin; D019108:Tight Junctions / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D062793:Occludin