Alcohol preference: association with reduced striatal nicotinic receptors.
This study was designed to determine whether inherent alcohol preference is associated with differential expression of central nicotinic receptors. [(3)H]Cytisine and [(125)I]alpha-bungarotoxin binding-site, ligands selective for alpha4beta2 and alpha7 nicotinic receptor subtypes, respectively, were determined in various brain regions of alcohol-preferring (P) and non-preferring (NP) rats. Only the striatum of P rats had a reduction in the number of binding sites for both ligands, compared to NP rats. The data suggest a link between striatal nicotinic receptors and alcohol preference.
Tizabi
Y
Y
Department of Pharmacology, College of Medicine, Howard University, 520 W Street NW, Washington, DC 20059, USA.
Getachew
B
B
Davila-Garcia
M
M
Taylor
R E
RE
D000470:Alkaloids / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D001392:Azocines; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000378:metabolism; D002038:Bungarotoxins / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D007457:Iodine Radioisotopes / Q000378:metabolism; D008297:Male; D011807:Quinolizines; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011978:Receptors, Nicotinic / Q000378:metabolism*; D014316:Tritium / Q000378:metabolism; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D001392:Azocines; D002038:Bungarotoxins; D000431:Ethanol; D007457:Iodine Radioisotopes; D011807:Quinolizines; D011978:Receptors, Nicotinic; D014316:Tritium; C004712:cytisine; D000093843:Quinolizidine Alkaloids