title: High-sensitivity single-shot perfusion-weighted fMRI.
abstract: A method is presented for measurement of perfusion changes during brain activation using a single-shot pulsed spin labeling technique. By employing a double-inversion labeling strategy, stationary tissue (background) signal was suppressed while minimally affecting perfusion sensitivity. This allowed omission of the otherwise required reference scan, resulting in twofold-improved temporal resolution. The method was applied to visual and motor cortex activation studies in humans, and compared to standard FAIR-type perfusion labeling techniques. Experiments performed at 1.5T and 3.0T indicate a close to 90% suppression of background signal, at a cost of an 11% and 9%, respectively, reduction in perfusion signal. Combined with the twofold increase in signal averaging, and a reduction in background signal fluctuations, this resulted in a 64% (1.5T, N = 3) and a 128% (3T, N = 4) overall improvement in sensitivity for the detection of activation-related perfusion changes. Magn Reson Med 46:88-94, 2001. Published 2001 Wiley-Liss, Inc.
authors.affiliation: Laboratory of Diagnostic Radiology Research (CC), National Institutes of Health, 9000 Rockville Pike, Bethesda, MD 20892, USA. jhd@helix.nih.gov
authors.forename: J H
authors.initials: JH
authors.lastname: Duyn
authors.forename: C X
authors.initials: CX
authors.lastname: Tan
authors.forename: P
authors.initials: P
authors.lastname: van Gelderen
authors.forename: M N
authors.initials: MN
authors.lastname: Yongbi
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010477:Perfusion