title: Targeted topical steroid therapy in sudden sensorineural hearing loss.
abstract: OBJECTIVE
  To treat patients with sudden sensorineural hearing loss (SSNL) who failed oral prednisone therapy by using a round window membrane (RWM) microcatheter. This topical delivery strategy sought to improve effectiveness of steroid treatment to the inner ear by targeting drug delivery to the RWM.
  
  
  METHODS
  Nonrandomized prospective design.
  
  
  METHODS
  Tertiary care facility.
  
  
  METHODS
  Six patients with severe unilateral SSHL, five of whom were refractory to a course of oral steroid therapy treated within 6 weeks of SSHL and three additional patients treated more than 6 weeks after SSHL.
  
  
  METHODS
  Therapeutic use of RWM catheter.
  
  
  METHODS
  Pure-tone averages (PTAs) and word identification scores (WIS).
  
  
  RESULTS
  Five of the six patients treated within 6 weeks of SSHL improved their WIS. Of the six, four returned to baseline hearing, one recovered hearing that could benefit by hearing amplification, and one regained moderate improvement in PTA but not WIS.
  
  
  CONCLUSIONS
  Targeted topical steroid administration avoids the significant systemic side effects of oral steroids and may offer more effective dosing than simple transtympanic injection of medicine. Although these findings are preliminary, it is possible that after further study, targeted drug delivery may be a useful technique to consider in patients with severe to profound hearing loss that have failed all other management options.
authors.affiliation: The Department of Defense Spatial Orientation Center, Naval Medical Center, San Diego, California 92134-2200, USA.
authors.forename: R D
authors.initials: RD
authors.lastname: Kopke
authors.forename: M E
authors.initials: ME
authors.lastname: Hoffer
authors.forename: D
authors.initials: D
authors.lastname: Wester
authors.forename: M J
authors.initials: MJ
authors.lastname: O'Leary
authors.forename: R L
authors.initials: RL
authors.lastname: Jackson
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D001301:Audiometry, Pure-Tone; D006319:Hearing Loss, Sensorineural / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D012405:Round Window, Ear; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D000893:Anti-Inflammatory Agents; D008775:Methylprednisolone