title: On-line measurement of human CNS re-organization.
abstract: Based on measurements of relative phase and frequency coordination of time-space distributed firing of neurons in the human nervous system, methods have been developed with which it is possible to functionally re-organize the lesioned or not optimally functioning human central nervous system (CNS) and to measure on-line the organization (the coordination dynamics) of the CNS non-invasively. By measuring the present coordination dynamics at different times with ongoing coordination dynamic therapy when exercising on a special coordination dynamic therapy device, the progress in re-organization of the lesioned CNS can be quantified. The coordination dynamic recording method is derived from measurements of natural firing patterns of single neurons in the human CNS. The method is explained with load changes in the healthy CNS and with essential improvement in CNS organization following coordination dynamic therapy in traumatic brain lesion, spinal cord lesion, stroke, cerebral palsy, and myelomeningocele. Evaluations of CNS re-organization are discussed with respect to usefullness and ethics.
authors.affiliation: Department of Neurology and Rehabilitation, University Hospital Tampere, PB 2000, 33521 Tampere, Finland.
authors.forename: G
authors.initials: G
authors.lastname: Schalow
mesh_terms: D000328:Adult; D001676:Biofeedback, Psychology / Q000502:physiology; D002490:Central Nervous System / Q000502:physiology* / Q000503:physiopathology; D002493:Central Nervous System Diseases / Q000503:physiopathology / Q000534:rehabilitation*; D002675:Child, Preschool; D004576:Electromyography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D017774:Long-Term Potentiation / Q000502:physiology; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology; D009048:Motor Skills / Q000502:physiology; D009412:Nerve Fibers / Q000502:physiology; D009415:Nerve Net / Q000503:physiopathology; D009416:Nerve Regeneration / Q000502:physiology*; D009473:Neuronal Plasticity / Q000502:physiology*; D026741:Physical Therapy Modalities / Q000295:instrumentation*