The intracorporeal autoorganic biofilter of portal blood in portal hypertension surgery.
OBJECTIVE
The authors present the new surgical treatment method for portal hypertension by means of intracorporeal autoorganic biofilter of portal blood at the portosystemic shunt pathway. The hepatized spleen is used as the organic biofilter of portal blood.


METHODS
The experiments were carried out on 20 mongrel dogs, both sexes, 18-20 kg of body weight. The animals were divided into the four equal groups. The comparative evaluation of portal hypertension treatment efficiency by means of several vascular portosystemic shunts were performed after the portal hypertension modeling. On the animals of groups I and II, the mesenterico-caval and splenorenal shunts were performed, respectively. The hepatized autospleen was involved in the portosystemic shunt pathway in the animals of group III. The animals of group IV served as controls.


RESULTS
The reduction in perfusional pressure of the blood which flows to the liver led to damage of the organ's functional possibilities, significant disturbances to the hemodynamics and reduction of the liver detoxification possibilities, respectively, for several portocaval shunt creations during the portal hypertension model. On the other hand, the undetoxificated portal blood entrance into the system blood flow via the created shunt over the liver increased.


CONCLUSIONS
The hepatized autospleen insertion into the portosystemic bloodflow gave us the opportunity to perform the dosage passing of portal blood into the systemic bloodflow and to maintain the pressure of the portal blood, which flows to the liver. Moreover, the hepatized autospleen has shown such specific liver functions as glucogenesis, albumin synthesis and others.
Kakabadze
Z
Z
Organs and Tissues Preservation and Transplantation Laboratory, Tbilisi Medical Academy, 33 Chavchavadze Ave, 380079, Tbilisi, Georgia.
Benashvili
L
L
Berishvili
E
E
D000818:Animals; D019299:Decompression, Surgical; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D022781:Hepatocytes / Q000637:transplantation*; D006975:Hypertension, Portal / Q000601:surgery*; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000379:methods*; D008297:Male; D011170:Portasystemic Shunt, Surgical / Q000379:methods*; D013154:Spleen / Q000601:surgery*; D014182:Transplantation, Autologous; D016042:Transplantation, Heterotopic / Q000379:methods*