[Effects of vitamin A supplementation on nutritional markers on the follow-up of malnutrition in children].
Prospectively assessment of vitamin A supplemented during a follow-up of a protein-energy malnutrition rehabilitation included serum retinol, Retinol Binding Protein (RBP) and prealbumin (PA) determination. This study was conducted during one month on a group of 36 vitamin A (200,000 IU) supplemented malnourished children and 32 age-and sex-matched malnourished children receiving only a nutritional regimen. Determinations were carried out at days 0, 15 and 30. Protein marker concentrations increased steadily in supplemented children as compared to those in the untreated group (p < 0.05, Student's t test). On the other hand, serum concentrations of the two proteins progressively regained normal values in the vitamin A supplemented group. Data also showed that retinol supplementation in conjunction with an appropriate nutritional diet is effective in raising serum concentrations of vitamin A and its binding proteins to normal levels. Therefore, we concluded that the results of this study demonstrates the importance of vitamin A supplementation in the management of these deficiency states.
Ake
M
M
Laboratoire de chimie analytique, Faculté de Pharmacie, BP V 34, Abidjan, Côte-d'Ivoire.
Poby
A G
AG
Malan
K A
KA
Tebi
A
A
Monnet
D
D
D015415:Biomarkers / Q000097:blood; D002675:Child, Preschool; D019587:Dietary Supplements; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007732:Kwashiorkor / Q000097:blood / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy; D008297:Male; D009748:Nutrition Disorders / Q000097:blood / Q000178:diet therapy* / Q000188:drug therapy*; D011228:Prealbumin / Q000032:analysis / Q000378:metabolism*; D011502:Protein-Energy Malnutrition / Q000097:blood / Q000150:complications / Q000178:diet therapy / Q000188:drug therapy; D012177:Retinol-Binding Proteins / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors; D014801:Vitamin A / Q000097:blood* / Q000627:therapeutic use*
D015415:Biomarkers; D011228:Prealbumin; D012177:Retinol-Binding Proteins; D014801:Vitamin A