Mucosal T cell response to reovirus.
During the last three decades, immunologists and gastroenterologists have witnessed the formation of mucosal immunology as a discipline in biomedical science, and studies of reovirus infection have substantially contributed to this evolution. We have focused on mucosal T cell responses induced by reovirus in conventional, germfree, nude, and NF-kappaB deficient mice. Several major facets of T cell function in the immune responses to this mucosal pathogen have been examined, including viral selection of oligoclonal-T cells, extrathymic T cell development, and distinct signaling pathways used by CD8 sublineages. In addition, our findings with virus-specific T cells selected in the mucosa have suggested novel mechanisms for the rearrangement, selection, and expansion of TCR genes. With the increasing application of molecular tools, reovirus will continue to be a useful model pathogen to study mucosal immunology and will further our understanding of mucosal immunity in health and disease.
Chen
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Department of Research Medicine, Vanderbilt University, Nashville, TN, USA.
Rubin
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D000328:Adult; D000818:Animals; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D019070:Cell Lineage; D017637:Clonal Deletion; D005753:Gastric Mucosa / Q000276:immunology; D015329:Gene Rearrangement, T-Lymphocyte; D005856:Germ-Free Life; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology; D008221:Lymphoid Tissue / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D018345:Mice, Knockout; D008819:Mice, Nude; D009092:Mucous Membrane / Q000276:immunology*; D016328:NF-kappa B / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D017393:RNA Editing; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics / Q000276:immunology; D012087:Reoviridae / Q000276:immunology*; D012088:Reoviridae Infections / Q000276:immunology; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D016328:NF-kappa B; D016692:Receptors, Antigen, T-Cell, gamma-delta