Chromosomal aberrations in Bloom syndrome patients with myeloid malignancies.
Bloom syndrome (BS) predisposes affected individuals to a wide variety of neoplasms including hematological malignancies. Thus far, cytogenetic findings in hematological neoplasms have been reported in only a few BS patients. We present the karyotypic findings in a BS patient diagnosed with acute myeloid leukemia (AML), FAB subtype M1, and a review of the literature, showing the preferential occurrence of total or partial loss of chromosome 7 in BS patients with AML or myelodysplastic syndromes (MDS).
Poppe
B
B
Center for Medical Genetics, De Pintelaan 185, B-9000 Gent, Belgium.
Van Limbergen
H
H
Van Roy
N
N
Vandecruys
E
E
De Paepe
A
A
Benoit
Y
Y
Speleman
F
F
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001816:Bloom Syndrome / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*