title: Optic disc changes following trabeculectomy: longitudinal and localisation of change.
abstract: OBJECTIVE
  To determine whether there were any changes in the optic disc at 2 years after trabeculectomy. To determine the factors that most influenced change and whether change was localised to any region of the optic disc.
  
  
  METHODS
  95 patients undergoing routine trabeculectomy as part of the ongoing Moorfields/MRC 5-fluorouracil trial were recruited into the study. Eyes were imaged preoperatively (4 (SD 3) weeks) with the Heidelberg retina tomograph (HRT, Heidelberg Engineering), and at 3 months (SD 2 weeks), 1 year (SD 1 month), and 2 years (SD 1 month) after surgery. Parameters investigated for change were rim area, rim volume, and maximum cup depth. The predefined segment analysis available on the HRT analysis software was used to determine segmental change.
  
  
  RESULTS
  The images of 70 patients were analysed. Intraocular pressure reduced from 22.25 (SD 3.76) mm Hg, at the time of preoperative imaging to 15.27 (SD 4.96) mm Hg at 3 months, 14.38 (SD 3.89) mm Hg at 1 year, and 13.80 (SD 3.54) mm Hg at 2 years after trabeculectomy. An increase in rim area and rim volume was present at all time points after surgery, but was only found to be statistically significant at 2 years after surgery. Maximum depth of cup reduced by month 3 and month 12, but showed a slight increase at 2 years after surgery, although this was still lower than the preoperative measure. Segmental analysis found a significant change in rim volume in the nasal, inferonasal, superonasal, and superotemporal regions at 2 years after surgery. No significant regional localisation for change was found at any other time point or in any other parameter investigated.
  
  
  CONCLUSIONS
  Reversal of disc cupping is present at 2 years after trabeculectomy. The factor most influencing change is reduction of intraocular pressure. Segmental analysis showed that change in rim volume was greatest in the nasal, inferonasal, superonasal and superotemporal regions at 2 years.
authors.affiliation: Wound Healing Research Unit, Department of Pathology, Institute of Ophthalmology, London, UK. a.kotecha@ucl.ac.uk
authors.forename: A
authors.initials: A
authors.lastname: Kotecha
authors.forename: D
authors.initials: D
authors.lastname: Siriwardena
authors.forename: F W
authors.initials: FW
authors.lastname: Fitzke
authors.forename: R A
authors.initials: RA
authors.lastname: Hitchings
authors.forename: P T
authors.initials: PT
authors.lastname: Khaw
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005901:Glaucoma / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure / Q000502:physiology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D009898:Optic Disk / Q000473:pathology*; D012984:Software; D018709:Statistics, Nonparametric; D014130:Trabeculectomy