Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease.
A significant increase of 267C allele of the 5-HT(6) receptor gene has been reported in patients with Alzheimer's disease (AD). Because a deficit in serotonergic neurotransmission is involved in major depression, we tried to find out whether 267C allele is associated with depressive disorders in AD. A psychiatrist interviewed all AD patients and their caregivers for evidence of depression using a Chinese version of the Standard Clinical Interview for DSM-III-R. The difference in the 5-HT(6) genotype or allele distributions between the AD patients with depressive disorders (n = 25) and those without (n = 120) was not significant.
Liu
H C
HC
Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. hcliu@vghtpe.gov.tw
Hong
C J
CJ
Liu
C Y
CY
Lin
K N
KN
Tsai
S J
SJ
Liu
T Y
TY
Chi
C W
CW
Wang
P N
PN
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000150:complications / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011985:Receptors, Serotonin / Q000235:genetics*; D012720:Severity of Illness Index; D013624:Taiwan
D011985:Receptors, Serotonin; C097216:serotonin 6 receptor