title: Carbohydrate metabolism in sickle cell patients using a subdermal implant containing nomegestrol acetate (Uniplant).
abstract: Uniplant, a second-generation contraceptive implant, has been demonstrated to promote a significant improvement in the overall well-being of women with sickle cell anemia. It has been suggested that the discrete increase in blood glucose levels observed in Uniplant users could be a contributory factor for clinical improvement. Ten healthy sickle cell patients were enrolled in the study. An oral glucose tolerance test was performed prior to implant insertion and at 1, 6, and 12 months of therapy. Blood glucose and insulin were measured before and at 30, 60, 120, and 180 min after a 75-g glucose load. The glucose and insulin areas under the curves were calculated. Fasting glycosylated hemoglobin was also measured. No significant changes were observed in glycosylated hemoglobin, glucose or insulin. We conclude that Uniplant is a safe contraceptive for sickle cell patients.
authors.affiliation: Maternidade Climério de Oliveira, Federal University of Bahia, Salvador, Bahia, Brazil. ionecb@terra.com.br
authors.forename: I C
authors.initials: IC
authors.lastname: Barbosa
authors.forename: O A
authors.initials: OA
authors.lastname: Ladipo
authors.forename: M L
authors.initials: ML
authors.lastname: Nascimento
authors.forename: C
authors.initials: C
authors.lastname: Athayde
authors.forename: C
authors.initials: C
authors.lastname: Hirsch
authors.forename: R
authors.initials: R
authors.lastname: Lopes
authors.forename: B
authors.initials: B
authors.lastname: Matias
authors.forename: E
authors.initials: E
authors.lastname: Coutinho
mesh_terms: D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood*; D019540:Area Under Curve; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D004343:Drug Implants; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D008535:Megestrol; D009649:Norpregnadienes / Q000008:administration & dosage*; D045167:Progesterone Congeners / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D004343:Drug Implants; D005947:Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D008535:Megestrol; D009649:Norpregnadienes; D045167:Progesterone Congeners; C038501:nomegestrol acetate