[Rice and bean diets increase hepatic and plasmatic activity of gammaglutamyltranspeptidase in young rats].
The effect of feeding rice and bean diets in both hepatic and plasmatic activity of gamma-glutamyltranspeptidase-(GGT-EC 2.3.2.2) activity was evaluated in growing-rats (Experiment A) and mature rats (Experiment B). During 28 days, the animals were fed with isocaloric-diets composed by tree levels of rice, bean or rice-and-bean protein. Similarly with the aproteic group, a significant increase on both the hepatic and plasmatic GGT activity were showed with the lowest levels of protein, when compared with 25% casein control group. This rise was more effective in growing-rats fed on legume-based diets (as bean or rice-and-bean diets), making evident a differential effect of age and an exacerbated effect of the protein restriction with the lowest sulfur amino acids disposal. These alterations suggest a metabolic adaptation of GGT to both the inadequate protein and sulfur-amino acid levels, thus supporting the hypothesis that the Glutathione levels may be reduced by these legume-based diets.
de Oliveira
I M
IM
Departamento de Enfermagem em Saúde Coletiva, Laboratório de Nutrição, Escola de Enfermagem, Universidade de São Paulo, Brasil.
Fujimori
E
E
da Silva
L
L
D000704:Analysis of Variance; D000818:Animals; D007887:Fabaceae; D005721:Glutamate-Cysteine Ligase / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D009929:Organ Size; D012275:Oryza; D010946:Plants, Medicinal; D011506:Proteins / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000032:analysis; D015430:Weight Gain
D011506:Proteins; D012709:Serum Albumin; D005721:Glutamate-Cysteine Ligase