Testing for Helicobacter pylori in dyspeptic patients suspected of peptic ulcer disease in primary care: cross sectional study.
OBJECTIVE
To develop an easily applicable diagnostic scoring method to determine the presence of peptic ulcers in dyspeptic patients in a primary care setting; to evaluate whether Helicobacter pylori testing adds value to history taking.


METHODS
Cross sectional study.


METHODS
General practitioners' offices in the Utrecht area of the Netherlands.


METHODS
565 patients consulting a general practitioner about dyspeptic symptoms of at least two weeks' duration.


METHODS
The presence or absence of peptic ulcer; independent predictors of the presence of peptic ulcer as obtained from history taking and the added value of H pylori testing were quantified by using multivariate logistic regression analyses.


RESULTS
A history of peptic ulcer, pain on an empty stomach, and smoking were strong and independent diagnostic determinants of peptic ulcer disease, with odds ratios of 5.5 (95% confidence interval 2.6 to 11.8), 2.8 (1.0 to 4.0), and 2.0 (1.4 to 6.0) respectively. The area under the receiver operating characteristic curve (ROC area) of these determinants together was 0.71. Adding the H pylori test increased the ROC area only to 0.75. However, in a group of patients at high risk, identified by means of a simple scoring rule based on history taking, the predictive value for the presence of peptic ulcer increased from 16% to 26% after a positive H pylori test.


CONCLUSIONS
In the total group of dyspeptic patients in primary care, H pylori testing has no value in addition to history taking for diagnosing peptic ulcer disease. In a subgroup of patients at high risk of having peptic ulcer disease, however, it might be useful to test for and treat H pylori infections.
Weijnen
C F
CF
Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, Location Stratenum, Universiteitsweg 100, 3584 CG Utrecht, Netherlands. c.f.weijnen@med.uu.nl
Numans
M E
ME
de Wit
N J
NJ
Smout
A J
AJ
Moons
K G
KG
Verheij
T J
TJ
Hoes
A W
AW
D000328:Adult; D003430:Cross-Sectional Studies; D004415:Dyspepsia / Q000209:etiology / Q000382:microbiology*; D005260:Female; D016481:Helicobacter Infections / Q000150:complications* / Q000175:diagnosis; D016480:Helicobacter pylori / Q000302:isolation & purification*; D006801:Humans; D016015:Logistic Models; D008297:Male; D008487:Medical History Taking; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications / Q000382:microbiology*; D011320:Primary Health Care; D012372:ROC Curve; D012307:Risk Factors