title: Subanesthetic isoflurane affects task-induced brain activation in a highly specific manner: a functional magnetic resonance imaging study.
abstract: BACKGROUND
  Functional magnetic resonance imaging of blood oxygenation level-dependent signal changes offers a very promising approach to investigate activated neural networks during anesthesia.
  
  
  METHODS
  Sixteen healthy male volunteers, assigned into two groups of eight subjects (isoflurane group, control group), were investigated by functional magnetic resonance imaging during different experimental conditions. The isoflurane group successively breathed air (baseline condition), isoflurane in air (0.42 vol% inspiratory; isoflurane condition) and air again (recovery condition) while performing a visual search task, whereas the control group breathed air during all experimental conditions. Functional magnetic resonance images were acquired during the entire experimental session. In addition, reaction times and error rates were recorded.
  
  
  RESULTS
  A significant isoflurane-related decrease (z > 3.1 corresponding to P < 0.001) in task-induced brain activation was found in three distinct cortical regions: the right anterio-superior insula (Talairach coordinates: x = 32, y = 22, z = 8) and the banks of the left and right intraparietal sulcus (Talairach coordinates: x = -34, y = -36, z = 32; x = 22, y = -60, z = 41, respectively). Subcortical structures (lateral geniculate nucleus) and the primary cortices (motor cortex, visual cortex) were not affected. All measured parameters indicated a nearly complete recovery of the affected networks within 5 min.
  
  
  CONCLUSIONS
  Our findings indicate that subanesthetic isoflurane affected task-induced activation in specific neural networks rather than causing a global decrease in functional activation.
authors.affiliation: Department of Anesthesiology and Intensive Care Therapy, University of Leipzig, Germany. heiw@medizin.uni-leipzig.de
authors.forename: W
authors.initials: W
authors.lastname: Heinke
authors.forename: C
authors.initials: C
authors.lastname: Schwarzbauer
mesh_terms: D000328:Adult; D000465:Algorithms; D018685:Anesthetics, Inhalation / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D001931:Brain Mapping; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007530:Isoflurane / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D008297:Male; D010775:Photic Stimulation; D011597:Psychomotor Performance / Q000187:drug effects*; D011930:Reaction Time / Q000187:drug effects; D014796:Visual Perception / Q000187:drug effects
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane