title: Development of potent and selective factor Xa inhibitors.
abstract: The development of potent and selective small molecule inhibitors of factor Xa is described.
authors.affiliation: Departments of Medicinal Chemistry, Structural Chemistry and Enzymology, Axys Pharmaceuticals, Inc., 385 Oyster Point Blvd., 94080, South San Francisco, CA, USA.
authors.forename: R
authors.initials: R
authors.lastname: Rai
authors.forename: A
authors.initials: A
authors.lastname: Kolesnikov
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: W B
authors.initials: WB
authors.lastname: Young
authors.forename: E
authors.initials: E
authors.lastname: Leahy
authors.forename: P A
authors.initials: PA
authors.lastname: Sprengeler
authors.forename: E
authors.initials: E
authors.lastname: Verner
authors.forename: W D
authors.initials: WD
authors.lastname: Shrader
authors.forename: J
authors.initials: J
authors.lastname: Burgess-Henry
authors.forename: J C
authors.initials: JC
authors.lastname: Sangalang
authors.forename: D
authors.initials: D
authors.lastname: Allen
authors.forename: X
authors.initials: X
authors.lastname: Chen
authors.forename: B A
authors.initials: BA
authors.lastname: Katz
authors.forename: C
authors.initials: C
authors.lastname: Luong
authors.forename: K
authors.initials: K
authors.lastname: Elrod
authors.forename: L
authors.initials: L
authors.lastname: Cregar
mesh_terms: D000578:Amidines / Q000737:chemistry / Q000494:pharmacology*; D000990:Antithrombin III / Q000138:chemical synthesis* / Q000494:pharmacology*; D003461:Crystallography; D015195:Drug Design; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000494:pharmacology; D005341:Fibrinolysin / Q000187:drug effects; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000187:drug effects*; D014357:Trypsin / Q000187:drug effects; D014568:Urokinase-Type Plasminogen Activator / Q000187:drug effects*
chemical_list: C433825:2-(3-bromo-2-hydroxy-5-methylphenyl)-1H-indole-5-carboxamidine; D000578:Amidines; D004791:Enzyme Inhibitors; D007211:Indoles; D000990:Antithrombin III; D014357:Trypsin; D013917:Thrombin; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator