title: Effect of pravastatin in mildly hypercholesterolemic young men on serum matrix metalloproteinases.
abstract: Pravastatin decreases serum MMP-9 concentration in clinically healthy men. This may reflect reduction of nonsymptomatic chronic arterial inflammation.
authors.affiliation: Department of Medical Biochemistry, University of Tampere Medical School, Tampere, Finland.
authors.forename: A
authors.initials: A
authors.lastname: Kalela
authors.forename: R
authors.initials: R
authors.lastname: Laaksonen
authors.forename: T
authors.initials: T
authors.lastname: Lehtimäki
authors.forename: T A
authors.initials: TA
authors.lastname: Koivu
authors.forename: M
authors.initials: M
authors.lastname: Höyhtyä
authors.forename: T
authors.initials: T
authors.lastname: Janatuinen
authors.forename: P
authors.initials: P
authors.lastname: Pöllänen
authors.forename: R
authors.initials: R
authors.lastname: Vesalainen
authors.forename: P
authors.initials: P
authors.lastname: Saikku
authors.forename: J
authors.initials: J
authors.lastname: Knuuti
authors.forename: S T
authors.initials: ST
authors.lastname: Nikkari
mesh_terms: D000328:Adult; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D005838:Genotype; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood* / Q000187:drug effects / Q000235:genetics; D011110:Polymorphism, Genetic; D017035:Pravastatin / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D020780:Matrix Metalloproteinase 9; D017035:Pravastatin