title: Gas transfer performance of a hollow fiber silicone membrane oxygenator: ex vivo study.
abstract: Based on the results of in vitro studies of many experimental models, a silicone hollow fiber membrane oxygenator for pediatric cardiopulmonary bypass (CPB) and extracorporeal membrane oxygenation (ECMO) was developed using an ultrathin silicone hollow fiber with a 300 microm outer diameter and a wall thickness of 50 microm. In this study, we evaluated the gas transfer performance of this oxygenator simulating pediatric CPB and ECMO conditions. Two ex vivo studies in a pediatric CPB condition for 6 h and 5 ex vivo studies in an ECMO condition for 1 week were performed with venoarterial bypass using healthy calves. At a blood flow rate of 2 L/min and V/Q = 4 (V = gas flow rate, Q = blood flow rate) (pediatric CPB condition), the O2 and CO2 gas transfer rates were maintained at 97.44 +/- 8.88 (mean +/- SD) and 43.59 +/- 15.75 ml/min/m2, respectively. At a blood flow rate of 1 L/min and V/Q = 4 (ECMO condition), the O2 and CO2 gas transfer rates were maintained at 56.15 +/- 8.49 and 42.47 +/- 9.22 ml/min/m2, respectively. These data suggest that this preclinical silicone membrane hollow fiber oxygenator may be acceptable for both pediatric CPB and long-term ECMO use.
authors.affiliation: Baylor College of Medicine, Michael E. DeBakey Department of Surgery, Houston, Texas, U.S.A. kawahito@clin.med.tokushima-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Kawahito
authors.forename: T
authors.initials: T
authors.lastname: Maeda
authors.forename: T
authors.initials: T
authors.lastname: Takano
authors.forename: K
authors.initials: K
authors.lastname: Nonaka
authors.forename: J
authors.initials: J
authors.lastname: Linneweber
authors.forename: M
authors.initials: M
authors.lastname: Mikami
authors.forename: T
authors.initials: T
authors.lastname: Motomura
authors.forename: S
authors.initials: S
authors.lastname: Ichikawa
authors.forename: J
authors.initials: J
authors.lastname: Glueck
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: J
authors.initials: J
authors.lastname: Kuwana
authors.forename: Y
authors.initials: Y
authors.lastname: Nosé
mesh_terms: D000818:Animals; D001784:Blood Gas Analysis; D002417:Cattle; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation*; D008567:Membranes, Artificial; D010539:Permeability; D012828:Silicones
chemical_list: D008567:Membranes, Artificial; D012828:Silicones