title: Solid-supported benzotriazoles. 2. Synthetic auxiliaries and traceless linkers for the combinatorial synthesis of unsymmetrical ureas.
abstract: Resin-bound benzotriazole chemistry applied to the solid-phase synthesis of arrays of unsymmetrical aryl ureas is described here. The chemistry assessment process, the monomer rehearsal, the preparation of a discrete library by automated parallel synthesis, the parallel purification protocol employing solid-phase scavenging, and the complete analytical characterization of the library components are also presented.
authors.affiliation: Glaxo Wellcome Medicines Research Centre, Via A. Fleming 4, 37135 Verona, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Paio
authors.forename: R F
authors.initials: RF
authors.lastname: Crespo
authors.forename: P
authors.initials: P
authors.lastname: Seneci
authors.forename: M
authors.initials: M
authors.lastname: Ciraco