title: Effects of bilateral subthalamic nucleus stimulation on parkinsonian gait.
abstract: Gait analysis was carried out to assess the effects of L-dopa and bilateral subthalamic nucleus stimulation on gait velocity, cadence, stride length, and gait kinematics in nine patients with PD. Substantial effects of bilateral subthalamic nucleus stimulation on gait, with an increase in gait velocity and stride length comparable to that of a suprathreshold L-dopa dose, were found. Interestingly, stride length was more improved by L-dopa and cadence more by subthalamic nucleus stimulation. In two patients with freezing during the "on" period, subthalamic nucleus stimulation failed to reduce this symptom effectively.
authors.affiliation: Department of Neurology, Christian-Albrechts-Universität Kiel, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Stolze
authors.forename: S
authors.initials: S
authors.lastname: Klebe
authors.forename: M
authors.initials: M
authors.lastname: Poepping
authors.forename: D
authors.initials: D
authors.lastname: Lorenz
authors.forename: J
authors.initials: J
authors.lastname: Herzog
authors.forename: W
authors.initials: W
authors.lastname: Hamel
authors.forename: B
authors.initials: B
authors.lastname: Schrader
authors.forename: J
authors.initials: J
authors.lastname: Raethjen
authors.forename: R
authors.initials: R
authors.lastname: Wenzelburger
authors.forename: H M
authors.initials: HM
authors.lastname: Mehdorn
authors.forename: G
authors.initials: G
authors.lastname: Deuschl
authors.forename: P
authors.initials: P
authors.lastname: Krack
mesh_terms: D000978:Antiparkinson Agents / Q000627:therapeutic use; D001696:Biomechanical Phenomena; D004599:Electric Stimulation Therapy; D005684:Gait; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology* / Q000628:therapy*; D020531:Subthalamic Nucleus / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa