title: Reproducibility of repeated human regional splenic blood flow measurements using [15O] water and positron emission tomography.
abstract: The reproducibility of measurement of regional splenic blood flow by dynamic positron emission tomography (PET) using [15O]water was evaluated. In 19 patients, the correlation between the first and second of two serial dynamic measurements was significant (P=1.78 x 10(-6); r=0.858). The regression equation was y = 1.06x, and the slope of the line described had a 95% confidence interval of 0.09. The error apparent between the two measurements was 0.129 (95% confidence interval 0.059). The results demonstrated sufficiently good reproducibility for measurements of regional splenic blood flow with PET and [15O]water to suggest use of this method for serial measurements intended to detect change, including drug effects.
authors.affiliation: Digestive Surgery, Kyoto Prefectural University of Medicine, Japan. taniguchi@1surg.kpu-m.ac.jp
authors.forename: H
authors.initials: H
authors.lastname: Taniguch
authors.forename: S
authors.initials: S
authors.lastname: Kunishima
authors.forename: T
authors.initials: T
authors.lastname: Koh
authors.forename: A
authors.initials: A
authors.lastname: Oguro
authors.forename: H
authors.initials: H
authors.lastname: Yamagishi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000465:Algorithms; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D012039:Regional Blood Flow / Q000502:physiology; D015203:Reproducibility of Results; D013154:Spleen / Q000098:blood supply* / Q000000981:diagnostic imaging*; D014055:Tomography, Emission-Computed; D014867:Water / Q000378:metabolism
chemical_list: D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D014867:Water