title: [Effectiveness of oral supplements of folates, vitamins B12 and B6 in hemodialysed patients. Preliminary results after 5 months of follow-up].
abstract: BACKGROUND
  Elevated serum levels of homocysteine have increasingly been associated as a risk factor of cardiovascular disease. Recent reports demonstrated that supplements of folates, vitamin B12 (B12) and vitamin B6 (B6) are effective in correcting serum Hcy levels in hemodialysed patients.
  
  
  OBJECTIVE
  to assess the effectiveness of oral supplements of folates, B12 and B6, in order to reduce serum Hcy levels in our cohort of hemodialysed patients.
  
  
  METHODS
  Sixty-one hemodialysed patients have been enrolled in the study (age 68+/-13 years; hemodialysis 62+/-42 months). Oral supplements of calcium folinate (30 mg 3 times a week), B12 (500 mg 3 times a week) and B6 (200 mg 3 times a week) were administered at the end of each hemodialysis session. Serum levels of Hcy, folic acid and B12 were tested at the beginning of the study and at 2 month intervals.
  
  
  RESULTS
  After 5 months of follow-up, serum levels of Hcy were normalised in 19% of our patients and in total 70% of them showed a reduction >8% when compared with the basal Hcy levels. No side effects related to folates, B12 or B6 supplementation were observed.
  
  
  CONCLUSIONS
  Oral supplements of folates, B12 and B6 are a safe and effective treatment of hyperhomocysteinemia in hemodialysed patients.
authors.affiliation: Servizio di Nefrologia e Dialisi, Ospedale S. Andrea, Vercelli, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Sepe
authors.forename: S
authors.initials: S
authors.lastname: Ottone
authors.forename: G
authors.initials: G
authors.lastname: Patrucco
authors.forename: P
authors.initials: P
authors.lastname: Cecere
authors.forename: P
authors.initials: P
authors.lastname: Colombo
authors.forename: G
authors.initials: G
authors.lastname: Cagna
authors.forename: L
authors.initials: L
authors.lastname: Costantini
authors.forename: G
authors.initials: G
authors.lastname: Piccini
authors.forename: O
authors.initials: O
authors.lastname: Filiberti
authors.forename: C
authors.initials: C
authors.lastname: Peona
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D019587:Dietary Supplements; D005260:Female; D005492:Folic Acid / Q000008:administration & dosage*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors; D014805:Vitamin B 12 / Q000008:administration & dosage*; D025101:Vitamin B 6 / Q000008:administration & dosage*
chemical_list: D025101:Vitamin B 6; D005492:Folic Acid; D014805:Vitamin B 12