Further characterization of apolipoprotein B genetic variations in Taiwanese.
Apolipoprotein B (apoB, protein; APOB, gene) is the main protein component of low-density lipoprotein (LDL) and plays an important role in blood lipid metabolism. Previously, we have reported four APOB coding regions, 5' signal peptide, and 3' repeat sequence polymorphisms in our population. In this report, we further characterize other APOB genetic variations. The results illustrate that the mutation frequencies for Arg3500Gln (1/846 alleles), Arg4019Trp (2/786 alleles), -265 C/T promoter region (0/264 alleles), and intron 2 A/G (0/450 alleles) are very low. Our population showed a frequency of 68.9% for the B4311 Ser allele. The B4311 Asn allele was associated with a higher apoB level than the Ser group (p < 0.05) in normal controls. In the normal controls, a higher B4311 Asn/Asn genotype frequency was found in the group with total cholesterol (TC) > 200 mg/dL and apoB concentration > 85 mg/dL than in the group with a TC < 200 mg/dL and apoB < 85 mg/dL (p = 0.03 for TC comparison).
Wu
J H
JH
Department of Microbiology and Immunology, College of Medicine, Chang Gung University, Taiwan.
Lee
Y T
YT
Hsu
H C
HC
Hsieh
L L
LL
Wen
M S
MS
Chern
M S
MS
Wu
D
D
D000704:Analysis of Variance; D001055:Apolipoproteins B / Q000235:genetics*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000235:genetics*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D013624:Taiwan
D001055:Apolipoproteins B; D008055:Lipids