title: Multivariate analysis of factors influencing quality of life and utility in patients with haemophilia.
abstract: OBJECTIVE
  Although several studies have determined quality of life (QOL) in patients with hemophilia, generic questionnaires have rarely been used. The objectives of our study were; 1) to measure QOL and utility in patients with hemophilia using the Short Form 36 (SF-36) and the EuroQOL questionnaires; 2) to evaluate the influence of some clinical variables on QOL and utility; 3) to assess the correlation between the two questionnaires.
  
  
  METHODS
  All consecutive patients with hemophilia were asked to complete the SF-36 and the EuroQOL questionnaires. The following information was recorded from each patient: age, type of hemophilia, severity of disease, HCV and HIV infection, number of bleeding episodes and cumulative dose of coagulation factors over the previous year. These items were entered into a multivariate analysis to assess their effect on QOL. Correlation analyses were conducted to evaluate the relationship between the EuroQOL and SF-36.
  
  
  RESULTS
  Fifty-six patients completed the SF-36 and the EuroQOL questionnaires. The mean scores of the SF-36 ranged from 55.2 (general health) to 74.7 (social functioning). The EuroQOLself-classifier and the EuroQOLvas showed a mean score of 0.67 (SD=0.26) and 0.66 (SD=0.17), respectively. Among the clinical variables, age significantly influenced both the EuroQOL and the SF-36 scores. The EuroQOL indices showed a statistically significant correlation with each dimension of the SF-36.
  
  
  CONCLUSIONS
  Our study quantified the degree to which QOL is impaired in patients with hemophilia by using both a generic questionnaire and a utility-based approach.
authors.affiliation: Drug Information Center, Azienda Ospedaliera Careggi, Florence, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Trippoli
authors.forename: M
authors.initials: M
authors.lastname: Vaiani
authors.forename: S
authors.initials: S
authors.lastname: Linari
authors.forename: G
authors.initials: G
authors.lastname: Longo
authors.forename: M
authors.initials: M
authors.lastname: Morfini
authors.forename: A
authors.initials: A
authors.lastname: Messori
mesh_terms: D000328:Adult; D017281:Cost of Illness; D006467:Hemophilia A / Q000150:complications / Q000473:pathology / Q000523:psychology; D006801:Humans; D008875:Middle Aged; D015999:Multivariate Analysis; D011788:Quality of Life; D011795:Surveys and Questionnaires