title: Total synthesis of agosterol A: an MDR-modulator from a marine sponge.
abstract: The first total synthesis of agosterol A, a modulator of multidrug resistance (MDR) mediated by P-gp and MRP1, and isolated from a marine sponge, was achieved from ergosterol by utilizing a regioselective epoxy-cleavage reaction and regioselective dehydroxylation as the key reactions.
authors.affiliation: Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Murakami
authors.forename: M
authors.initials: M
authors.lastname: Sugimoto
authors.forename: M
authors.initials: M
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D018432:Drug Resistance, Multiple; D004875:Ergosterol / Q000737:chemistry; D007202:Indicators and Reagents; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000138:chemical synthesis*
chemical_list: D007202:Indicators and Reagents; D013261:Sterols; C429345:agosterol A; D004875:Ergosterol