title: Large-scale production of mouse phenotypes: the search for animal models for inherited diseases in humans.
abstract: This paper is aimed principally at bioinformaticians and biologists as an introduction to recent advances in mouse mutagenesis, concentrating on genome-wide screens utilising the powerful mutagen N-ethyl-N-nitroso-urea (ENU). It contains a brief background to the underlying genetics as well as details of the practical aspects of organisation and data capture for such projects.
authors.affiliation: Institute of Experimental Genetics at the GSF Research Centre for Environment and Health, Munich, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Hrabé de Angelis
authors.forename: M
authors.initials: M
authors.lastname: Strivens
mesh_terms: D000818:Animals; D019295:Computational Biology; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D004195:Disease Models, Animal; D005038:Ethylnitrosourea / Q000633:toxicity; D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006801:Humans; D008297:Male; D051379:Mice / Q000235:genetics*; D016296:Mutagenesis; D009153:Mutagens / Q000633:toxicity; D010641:Phenotype; D012662:Semen Preservation
chemical_list: D009153:Mutagens; D005038:Ethylnitrosourea