Role played by the response regulator Ris in Bordetella bronchiseptica resistance to macrophage killing.
Previous studies suggested that the persistence in eukaryotic cells of a Bordetella bronchiseptica mutant carrying an insertion in the locus encoding the response regulator RisAS is impaired. This suggested that ris-dependent products are required for the intracellular survival of bacteria. In this study we demonstrate that ris-regulated products play a role in B. bronchiseptica resistance against both phagosomal acidification and reactive oxygen intermediates.
Zimna
K
K
Division of Microbiology, GBF-German Research Centre for Biotechnology, Braumschweig, Germany.
Medina
E
E
Jungnitz
H
H
Guzmán
C A
CA
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001426:Bacterial Proteins; D016950:Bordetella bronchiseptica / Q000187:drug effects / Q000235:genetics* / Q000502:physiology*; D015169:Colony Count, Microbial; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism; D005798:Genes, Bacterial / Q000502:physiology; D005809:Genes, Regulator / Q000502:physiology; D018942:Macrolides; D017737:Macrophages, Peritoneal / Q000201:enzymology / Q000378:metabolism / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011956:Receptors, Cell Surface / Q000235:genetics / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D016166:Free Radical Scavengers; D018942:Macrolides; D011956:Receptors, Cell Surface; C114918:RisA protein, Bordetella; D000251:Adenosine Triphosphatases