[The cytotoxic effects of the adriamycin magnetic albumin microspheres combined with external magnetic fields on the malignant tumor cells].
This study sought to assess the inhibitory effects of the adriamycin magnetic albumin microspheres (ADM-MAMs) on Walker-256 malignant tumor cells in vitro induced by the permanent magnetic fields. The cultured Walker-256 cells were divided into three groups; the group of ADM-MAMs combined with magnetic fields, the group of AMD-MAMs without magnetic fields, and ADM group. The growth states of the cells were observed and photographed under the inverted microscope. The inhibitory rates(IR) were assayed by the modified MTT colorimetric method. The results showed that the IR of the ADM-MAMs group were similar to those of the ADM group (P > 0.05), but the group of ADM-MAMs combined with magnetic fields had obviously higher IR and significant changes of the cells' shapes. These findings indicate that the anticancer effect of ADM-MAMs on malignant tumor cells is similar to that of ADM, and such effect can be increased by the combined use of ADM-MAMs and external magnetic fields.
Tao
K
K
Department of General Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022.
Chen
D
D
Tian
Y
Y
Wu
Z
Z
D000418:Albumins; D000818:Animals; D002279:Carcinoma 256, Walker / Q000473:pathology*; D048429:Cell Size / Q000187:drug effects / Q000528:radiation effects; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000494:pharmacology*; D008280:Magnetics / Q000627:therapeutic use*; D008863:Microspheres; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects
D000418:Albumins; D004317:Doxorubicin