Viral load increases in SJL/J mice persistently infected by Theiler's virus after inactivation of the beta(2)m gene.
We show that inactivating the beta(2)m gene increases the viral load of SJL/J mice persistently infected by Theiler's virus. Together with previous results, this shows that the characteristics of Tmevp1, a locus which controls the amount of viral RNA that persists in the central nervous system, are those of an H-2 class I gene.
Aubagnac
S
S
Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, 75724 Paris Cedex 15, France.
Brahic
M
M
Bureau
J F
JF
D000818:Animals; D018188:Cardiovirus Infections / Q000235:genetics* / Q000821:virology*; D015967:Gene Expression Regulation, Viral; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D017945:Theilovirus / Q000235:genetics*; D019562:Viral Load
D015395:Histocompatibility Antigens Class I