title: Effect of nitrogen source and pH on siderophore production by Rhodotorula strains and their application to biocontrol of phytopathogenic moulds.
abstract: The production of rhodotorulic acid, a siderophore synthesized by Rhodotorula strains, was improved with the objective of achieving the biocontrol of phytopathogenic moulds. Rhodotorulic acid increased up to 60% in the presence of urea as a nitrogen source, pH near to 8 and a C:N ratio of 8:1. The siderophore-containing spent medium showed in vitro antifungal activity against important plant pathogens including Botrytis cinerea, which causes grey mould on a wide variety of host plants including numerous commercial crops. The antifungal activity was related to siderophore concentration.
authors.affiliation: Area de Tecnología Química y Biotecnología, Departamento de Química, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, 5700 San Luis, Argentina.
authors.forename: V
authors.initials: V
authors.lastname: Calvente
authors.forename: M E
authors.initials: ME
authors.lastname: de Orellano
authors.forename: G
authors.initials: G
authors.lastname: Sansone
authors.forename: D
authors.initials: D
authors.lastname: Benuzzi
authors.forename: M I
authors.initials: MI
authors.lastname: Sanz de Tosetti
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000935:Antifungal Agents / Q000378:metabolism* / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D009584:Nitrogen / Q000378:metabolism / Q000494:pharmacology*; D010572:Pest Control, Biological; D010879:Piperazines / Q000378:metabolism / Q000494:pharmacology; D010935:Plant Diseases / Q000382:microbiology; D012248:Rhodotorula / Q000145:classification / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism*; D017262:Siderophores / Q000096:biosynthesis* / Q000494:pharmacology*; D014508:Urea / Q000378:metabolism / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D000935:Antifungal Agents; D010879:Piperazines; D017262:Siderophores; C003305:rhodotorulic acid; D014508:Urea; D009584:Nitrogen