Acute parvovirus B19 infection during anti-retroviral therapy.
Human parvovirus B19 (B19) has been described as a causative agent of chronic anemia in human immunodeficiency virus type-1 (HIV-1)-infected patients. We report an HIV-1 infected patient who had been receiving anti-retroviral therapy who showed sudden pancytopenia. Primary B19 infection was confirmed by the detection of plasma viremia and seroconversion. Although clearance required a prolonged period of time, the patient eventually cleared the B19 viral DNA from the plasma. More than likely, highly active anti-retroviral therapy (HAART), including a protease inhibitor, played a role in clearing the virus.
Taguchi
H
H
Division of Infectious Diseases, Advanced Clinical Research Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan.
Takahashi
T
T
Goto
M
M
Nakamura
T
T
Iwamoto
A
A
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000821:virology*; D000208:Acute Disease; D000328:Adult; D019380:Anti-HIV Agents / Q000627:therapeutic use*; D000914:Antibodies, Viral / Q000097:blood; D023241:Antiretroviral Therapy, Highly Active; D018791:CD4 Lymphocyte Count; D017931:DNA Primers / Q000737:chemistry; D004279:DNA, Viral / Q000032:analysis; D016731:Erythema Infectiosum / Q000175:diagnosis / Q000821:virology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D010198:Pancytopenia / Q000175:diagnosis / Q000821:virology*; D016732:Parvovirus B19, Human / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D014766:Viremia / Q000175:diagnosis / Q000821:virology
D019380:Anti-HIV Agents; D000914:Antibodies, Viral; D017931:DNA Primers; D004279:DNA, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M