Antiretroviral-induced hepatic steatosis and lactic acidosis: case report and review of the literature.
As the prevalence of human immunodeficiency virus (HIV) infection continues to rise the clinician is encountered with a diagnostic challenge. Nonsurgical diseases such as acute colitis or enteritis can appear similar to such true surgical emergencies as abscess, perforation, or mesenteric ischemia. We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously. This entity should be kept in mind when evaluating the acute abdomen in the HIV-positive patient.
Ellozy
S
S
Department of Surgery, The Mount Sinai Medical Center, New York, New York 10029, USA.
Massen
R
R
Chao
L
L
Divino
C M
CM
D000006:Abdomen, Acute / Q000175:diagnosis; D000140:Acidosis, Lactic / Q000175:diagnosis*; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D016049:Didanosine / Q000009:adverse effects*; D005234:Fatty Liver / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000473:pathology; D017093:Liver Failure / Q000139:chemically induced* / Q000601:surgery
D019380:Anti-HIV Agents; D016049:Didanosine