Synthesis of a non-natural T-antigen containing glycosphingolipid.
A non natural glycosphingolipid containing the mucin derived, cancer associated disaccharide moiety Galbeta1-->3GalNAc, the T-antigen, alpha linked to a ceramide, has been synthesised via the protected disaccharide glycosyl trichloroacetimidate. The product has potential as a cancer vaccine.
Cipolla
L
L
Department of Chemistry, Valby, Denmark. laura.cipolla@unimib.it
Meldal
M
M
D015295:Antigens, Tumor-Associated, Carbohydrate / Q000737:chemistry* / Q000276:immunology; D019496:Cancer Vaccines / Q000138:chemical synthesis / Q000737:chemistry; D006028:Glycosphingolipids / Q000138:chemical synthesis* / Q000737:chemistry* / Q000276:immunology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
D015295:Antigens, Tumor-Associated, Carbohydrate; D019496:Cancer Vaccines; D006028:Glycosphingolipids; C016467:Thomsen-Friedenreich antigen