Axis formation and patterning in zebrafish.
A large collection of mutations affecting zebrafish embryogenesis was described in 1996. The cloning of the affected genes has now provided novel insights into the role and regulation of signaling by BMP, Nodal, Wnt, FGF, Hedgehog, Delta, Slit, retinoic acid and lipids. Detailed analyses have revealed a complex genetic network that patterns the early embryo.
Schier
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Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, Department of Cell Biology, New York University School of Medicine, New York 10016, New York, USA. schier@saturn.med.nyu.edu
D000818:Animals; D001368:Axis, Cervical Vertebra / Q000196:embryology*; D019521:Body Patterning / Q000502:physiology*; D004707:Endoderm / Q000502:physiology; D008648:Mesoderm / Q000502:physiology; D015027:Zebrafish / Q000196:embryology*