title: Functional genomics of the murine immune system.
abstract: The mouse and human genome sequences provide new opportunities to characterize mammalian gene functions on a genome-wide level. Toward this end, we have developed strategies for tagged-sequence mutagenesis in mice. Tagged-sequence mutagenesis has been used first, to analyze genes implicated in posttranscriptional gene regulation, and second, to identify genes important in immune cell development and function.
authors.affiliation: Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN 37232-2363, USA. ruleye@ctrvax.vanderbilt.edu
authors.forename: H E
authors.initials: HE
authors.lastname: Ruley
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D019175:DNA Methylation; D004260:DNA Repair; D004622:Embryo, Mammalian / Q000166:cytology; D020224:Expressed Sequence Tags; D005786:Gene Expression Regulation; D015723:Gene Library; D018390:Gene Targeting; D005796:Genes; D005804:Genes, Lethal; D005808:Genes, Recessive; D005813:Genes, Synthetic; D005822:Genetic Vectors / Q000235:genetics; D023281:Genomics; D034441:Heterogeneous-Nuclear Ribonucleoproteins; D006801:Humans; D007107:Immune System; D018836:Inflammation Mediators; D007970:Leukopenia / Q000235:genetics; D008213:Lymphocyte Activation / Q000235:genetics; D051379:Mice / Q000196:embryology / Q000235:genetics* / Q000276:immunology; D016297:Mutagenesis, Site-Directed; D010641:Phenotype; D011533:Proviruses / Q000235:genetics; D012326:RNA Splicing; D012190:Retroviridae / Q000235:genetics; D012261:Ribonucleoproteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D020718:Ribonucleoproteins, Small Nucleolar / Q000235:genetics; D013045:Species Specificity; D013234:Stem Cells
chemical_list: D034441:Heterogeneous-Nuclear Ribonucleoproteins; D018836:Inflammation Mediators; D012261:Ribonucleoproteins; D020718:Ribonucleoproteins, Small Nucleolar; C117377:ribonucleoprotein, U3 small nucleolar