Long-term behavior of secretory immunity in ileocecal and ileal orthotopic neobladders.
OBJECTIVE
To compare secretory immunity in cecal and ileal orthotopic neobladders, and to detect its permanence over time.


METHODS
IgA was studied in the urine of 33 patients with ileocecourethrostomy (ICUS) and 13 patients with ileal reservoir (IR). The mean follow-up was 55 months. Results were compared in terms of the type of operation, a healthy control group, and the time since surgery.


RESULTS
Urinary IgA levels were significantly higher in ICUS and IR patients than in normal controls. No significant differences in IgA concentrations were detected in patients with different reservoirs and with regard to time.


CONCLUSIONS
Both the reservoirs maintain the function of producing IgA. In particular no differences were detected over time and urine could be a permanent antigenic stimulus. IgA could be considered an adjunctive factor for upper urinary tract protection. For this reason we prefer to use a simple, indirect antireflux mechanism, thus avoiding direct manipulation of the uretero-intestinal anastomosis.
d'Addessi
A
A
Department of Urology, Università Cattolica del Sacro Cuore, Rome, Italy. catt.urologia@rm.unicatt.it
Racioppi
M
M
Fanasca
A
A
Menchinelli
P
P
Alcini
A
A
Delicato
G
G
Alcini
E
E
Scuderi
F
F
D000368:Aged; D002432:Cecum / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007082:Ileum / Q000601:surgery; D007071:Immunoglobulin A, Secretory / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D016476:Urinary Reservoirs, Continent
D007071:Immunoglobulin A, Secretory