title: Comparison of Gleason scores from sextant prostate biopsies and radical prostatectomy specimens.
abstract: OBJECTIVE
  We compared the Gleason scores obtained from sextant prostate biopsy and radical prostatectomy (RP) specimens in patients with localized prostate cancer.
  
  
  METHODS
  Sixty-one patients having a clinical diagnosis of localized prostate cancer underwent needle biopsy under transrectal ultrasonography (TRUS) and RP. Grading and staging were assigned based on Gleason scores and the TNM system, respectively.
  
  
  RESULTS
  Mean patient age was 65.5 +/- 13.43 years and mean PSA level was 14.69 +/- 3.95. Mean Gleason score for prostate biopsy and RP specimen were 5.85 +/- 0.7 and 6.34 +/- 1.44, respectively. With respect to clinical stage, there were 20 patients in stage 1 and 41 patients in stage 2 prostate cancer. Comparing the Gleason scores, the biopsy score was lower in 26 (42.26%) and higher than RP specimens in 7 (11.84%) cases, and there was agreement between the biopsy and RP specimens in 28 (45.9%) patients. The difference between the two Gleason scores was +/- 1 for 18 patients (29.5%) and +/- 2 or more for 17 patients (27.86%).
  
  
  CONCLUSIONS
  In our study, high Gleason score biopsies with elevated PSA level (>10 ng/ml) were risk factors for extraprostatic extension, and we demonstrated that Gleason scores were significantly correlated with seminal vesicle and lymph node invasion (p < 0.05). The Gleason scores of biopsy and RP specimens agreed with 45.9% of TRUS-guided sextant prostate biopsies, and this ratio was 91.1% in moderately differentiated tumors
authors.affiliation: Department of Urology, University of Ege Medical School, Izmir, Turkey. baltay@mail.koc.net
authors.forename: B
authors.initials: B
authors.lastname: Altay
authors.forename: A
authors.initials: A
authors.lastname: Kefi
authors.forename: O
authors.initials: O
authors.lastname: Nazli
authors.forename: R
authors.initials: R
authors.lastname: Killi
authors.forename: B
authors.initials: B
authors.lastname: Semerci
authors.forename: I
authors.initials: I
authors.lastname: Akar
mesh_terms: D000368:Aged; D001707:Biopsy, Needle / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery*; D012007:Rectum; D014463:Ultrasonography