title: Tetrasomy 21 as the sole acquired karyotypic abnormality in acute myeloblastic leukemia.
abstract: Peripheral blood and bone marrow analysis of a 79-year-old female led to a diagnosis of acute myeloblastic leukemia with differentiation (AML-M2). Chromosome analysis of the unstimulated bone marrow cells revealed 48, XX,+21,+21, and tetrasomy 21 was the sole cytogenetic abnormality in this constitutionally normal female patient.
authors.affiliation: Section of Internal Medicine, Kobe Kyodo Hospital, 2-Kubo-cho, Nagata-ku, 653-0041, Kobe, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Odagaki
authors.forename: T
authors.initials: T
authors.lastname: Sugimoto
authors.forename: M
authors.initials: M
authors.lastname: Matsuo
authors.forename: E
authors.initials: E
authors.lastname: Tatsumi
authors.forename: K
authors.initials: K
authors.lastname: Saigo
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics*