Behavioral properties of the trigeminal somatosensory system in rats performing whisker-dependent tactile discriminations.
To address several fundamental questions regarding how multiwhisker tactile stimuli are integrated and processed by the trigeminal somatosensory system, a novel behavioral task was developed that required rats to discriminate the width of either a wide or narrow aperture using only their large mystacial vibrissae. Rats quickly acquired this task and could accurately discriminate between apertures of very similar width. Accurate discriminations required a large number of intact facial whiskers. Systematic removal of individual whiskers caused a decrease in performance that was directly proportional to the number of whiskers removed, indicating that tactile information from multiple whiskers is integrated as rats gauge aperture width. In different groups of rats, different sets of whiskers were removed in patterns that preferentially left whisker rows or whisker arcs intact. These different whisker removals caused similar decreases in performance, indicating that individual whiskers within the vibrissal array are functionally equivalent during performance of this task. Lesions of the barrel cortex abolished the ability of rats to discriminate, demonstrating that this region is critically involved in this tactile behavior. Interestingly, sectioning the facial nerve, which abolished whisker movements, did not affect the ability to perform accurate discriminations, indicating that active whisker movements are not necessary for accurate performance of the task. Collectively, these results indicate that the trigeminal somatosensory system forms internal representations of external stimuli (in this case, aperture width) by integrating tactile input from many functionally equivalent facial whiskers and that the vibrissal array can function as a fine-grained distance detector without active whisker movements.
Krupa
D J
DJ
Department of Neurobiology, Duke University Medical Center, Durham, North Carolina 27710, USA. krupa@neuro.duke.edu
Matell
M S
MS
Brisben
A J
AJ
Oliveira
L M
LM
Nicolelis
M A
MA
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology; D004567:Electrodes, Implanted; D005154:Facial Nerve / Q000502:physiology; D018755:GABA Agonists / Q000494:pharmacology; D058785:GABA-A Receptor Agonists; D008297:Male; D008465:Mechanoreceptors / Q000502:physiology; D009118:Muscimol / Q000008:administration & dosage; D010812:Physical Stimulation / Q000295:instrumentation; D051381:Rats; D020318:Rats, Long-Evans; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*; D014110:Touch / Q000502:physiology*; D014276:Trigeminal Nerve / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation / Q000502:physiology*
D018755:GABA Agonists; D058785:GABA-A Receptor Agonists; D009118:Muscimol