Strength over time of a resorbable bioscaffold for body wall repair in a dog model.
The change in strength over time of a biomaterial derived from the small intestinal submucosa (SIS) was determined in a dog model of body wall repair. Full-thickness body wall defects measuring 8 x 12 cm were surgically created and then repaired with a multilaminate eight-layer form of SIS in 40 dogs. Five dogs were sacrificed at each of the following time points: 1 day, 4 days, 7 days, 10 days, and 1, 3, 6, and 24 months. Ball burst tests that measured biaxial ultimate load-bearing capability were performed on the device prior to implantation and on the device/implant site at the time of sacrifice. The strength of the device at the time of implant was approximately 73 +/- 12 pounds. The strength of the implant site diminished to 40 +/- 18 pounds at 10 days, and then progressively increased to a value of 156 +/- 26 pounds at 24 months (P < 0.05). The clinical utility of a degradable biomaterial such as SIS depends on a balance between the rate of degradation and the rate of host remodeling. Naturally occurring extracellular matrix scaffolds such as SIS show rapid degradation with associated and subsequent remodeling to a tissue with strength that exceeds that of the native tissue when used as a body wall repair device.
Badylak
S
S
Department of Biomedical Engineering, Purdue University, West Lafayette, Indiana 47907, USA. badylak@ecn.purdue.edu
Kokini
K
K
Tullius
B
B
Whitson
B
B
D000818:Animals; D019245:Compressive Strength; D004285:Dogs; D005109:Extracellular Matrix / Q000502:physiology*; D005260:Female; D006547:Hernia / Q000503:physiopathology*; D059685:Herniorrhaphy; D007413:Intestinal Mucosa; D007421:Intestine, Small; D008422:Materials Testing; D013242:Sterilization; D013314:Stress, Mechanical