Mannan-binding lectin enhances susceptibility to visceral leishmaniasis.
Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.
Santos
I K
IK
Department of Immunology and Infectious Diseases, Harvard School of Public Health, Children's Hospital, Boston, Massachusetts 02115, USA.
Costa
C H
CH
Krieger
H
H
Feitosa
M F
MF
Zurakowski
D
D
Fardin
B
B
Gomes
R B
RB
Weiner
D L
DL
Harn
D A
DA
Ezekowitz
R A
RA
Epstein
J E
JE
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002352:Carrier Proteins / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D037222:Collectins; D004198:Disease Susceptibility; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000378:metabolism; D037102:Lectins / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D018314:Leishmania infantum / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000276:immunology* / Q000469:parasitology; D008351:Mannans; D008875:Middle Aged; D009895:Opsonin Proteins / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D002352:Carrier Proteins; D037222:Collectins; D015850:Interleukin-6; D037102:Lectins; D008351:Mannans; D009895:Opsonin Proteins; D014409:Tumor Necrosis Factor-alpha