title: Cost analysis of two strategies for hepatitis A vaccination of hospital health-care personnel in an intermediate endemicity area.
abstract: The aim of the study was to carry out a cost analysis to allow the comparison of the cost of two vaccination strategies against Hepatitis A in health-care personnel. A total of 423 health-care workers were recruited at one General Hospital of Madrid, Spain. Blood specimens were obtained for anti-HAV antibody determination. The prevalence of anti-HAV antibody was 40% (95% CI: 35-45) and it was directly correlated with age. Cost analysis determined that the critical value of prevalence for vaccination with HAV vaccine was 23%. In hospital health-care workers < or =30 years in age, vaccination with HAV vaccine (without screening) would be the less costly strategy. In those >30 years in age, it would be less costly to screen for anti-HAV antibody first and vaccinate those who are antibody-negative.
authors.affiliation: Jefe de Servicio Medicina Preventiva, Hospital '12 de Octubre', Carretera de Andulucia Km 5, 28041, Madrid, Spain. jrj@medynet.com
authors.forename: J R
authors.initials: JR
authors.lastname: de Juanes
authors.forename: A
authors.initials: A
authors.lastname: González
authors.forename: M P
authors.initials: MP
authors.lastname: Arrazola
authors.forename: M
authors.initials: M
authors.lastname: San-Martín
mesh_terms: D000328:Adult; D003365:Costs and Cost Analysis; D005260:Female; D006282:Health Personnel; D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines / Q000191:economics*; D006508:Hepatitis Antibodies / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D014611:Vaccination
chemical_list: D035922:Hepatitis A Antibodies; D022362:Hepatitis A Vaccines; D006508:Hepatitis Antibodies