Prostatic adenocarcinoma with marked neuroendocrine differentiation.
A case is presented of prostatic cancer with marked neuroendocrine differentiation. Double-labeled immunohistochemical staining was performed with prostate-specific antigen and Chromogranin A. Both antibodies were localized to some of the cancer cells with Paneth cell-like features. Furthermore, most of the cancer cells were positively stained with luminal cell marker CAM 5.2, suggesting that neuroendocrine cells originated from the prostatic luminal cells.
Islam
A M
AM
Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan. islam@hosp.md.shinshu-u.ac.jp
Kato
H
H
Hayama
M
M
Kobayashi
S
S
Ota
H
H
Nishizawa
O
O
D000230:Adenocarcinoma / Q000473:pathology*; D002454:Cell Differentiation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*