[Surface CD2, CD4, CD8 markers and IL-2 and TNF-alpha cytokines in amyotrophic lateral sclerosis].
The cause of amyotrophic lateral sclerosis is still unknown. In the paper CD2, CD4 and CD8 markers on mononuclear cells as well as levels of TNF-alpha and IL-2 in sera from 15 patients with ALS were evaluated. There was a significant increase of TNF-alpha in sera of ALS patients in comparison with control group. This is the first such observation. It supports the concept that immune mechanisms may play a role in the pathogenesis of ALS.
Losy
J
J
Zakładu Neuroimmunologii Klinicznej Katedry Neurologii AM w Poznaniu.
Michałowska-Wender
G
G
D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000097:blood* / Q000276:immunology*; D015415:Biomarkers / Q000097:blood; D018801:CD2 Antigens / Q000097:blood; D015704:CD4 Antigens / Q000097:blood; D016827:CD8 Antigens / Q000097:blood; D006801:Humans; D007376:Interleukin-2 / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000737:chemistry; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
D015415:Biomarkers; D018801:CD2 Antigens; D015704:CD4 Antigens; D016827:CD8 Antigens; D007376:Interleukin-2; D014409:Tumor Necrosis Factor-alpha