title: Trisomy 16 as the sole anomaly in hematological malignancies. Three new cases and a short review.
abstract: We report on three cases, two with myelodysplastic syndrome (MDS) and one with acute lymphoblastic leukemia (ALL), displaying trisomy 16 as the sole cytogenetic anomaly. In none of these cases was a concomitant inv(16)(p13q22) detected by fluorescence in situ hybridization (FISH) or reverse transcription polymerase chain reaction (RT-PCR). Summarizing the literature, only six other cases cytogenetically characterized by an isolated trisomy 16 have been reported in hematological malignancies. These patients had either MDS, acute myeloblastic leukemia (AML), myelofibrosis, or ALL. All but one of these cases were aged less than 50.
authors.affiliation: Department of Hematology, Cliniques Universitaires St Luc, Université Catholique de Louvain, Brussels, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Guillaume
authors.forename: G
authors.initials: G
authors.lastname: Ameye
authors.forename: J
authors.initials: J
authors.lastname: Dierlamm
authors.forename: G
authors.initials: G
authors.lastname: Verhoef
authors.forename: C
authors.initials: C
authors.lastname: Duhem
authors.forename: A
authors.initials: A
authors.lastname: Ferrant
authors.forename: A
authors.initials: A
authors.lastname: Hagemeijer
authors.forename: C
authors.initials: C
authors.lastname: Verellen-Dumoulin
authors.forename: L
authors.initials: L
authors.lastname: Michaux
mesh_terms: D000328:Adult; D002885:Chromosomes, Human, Pair 16; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014314:Trisomy