title: Treatment of cicatricial pemphigoid with mycophenolate mofetil as a steroid-sparing agent.
abstract: BACKGROUND
  Cicatricial pemphigoid (CP) is a rare autoimmune bullous disease that affects the skin and mucous membranes. It commonly ends by serious complications such as blindness, stenosis, and stricture formation and is difficult to treat. Mycophenolate mofetil has been reported to be effective in the treatment of pemphigus vulgaris, pemphigus foliaceus, and bullous pemphigoid either as monotherapy or as a steroid-sparing agent.
  
  
  OBJECTIVE
  Our purpose was to evaluate the effectiveness of mycophenolate mofetil as a steroid-sparing agent in treating patients with CP.
  
  
  METHODS
  Three patients with CP were treated with mycophenolate mofetil and prednisolone.
  
  
  RESULTS
  All 3 patients responded very well to the therapy. None of them showed relapse of the disease for a follow-up period of 6 to 14 months after complete cessation of mycophenolate mofetil and prednisolone. No side effects were seen.
  
  
  CONCLUSIONS
  Mycophenolate mofetil appears to be a safe and effective steroid-sparing agent in the treatment of CP.
authors.affiliation: Department of Dermatology, University of Heinrich Heine, Düsseldorf, Germany. megahed@uni-duesseldorf.de
authors.forename: M
authors.initials: M
authors.lastname: Megahed
authors.forename: S
authors.initials: S
authors.lastname: Schmiedeberg
authors.forename: J
authors.initials: J
authors.lastname: Becker
authors.forename: T
authors.initials: T
authors.lastname: Ruzicka
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009173:Mycophenolic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D010390:Pemphigoid, Benign Mucous Membrane / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007166:Immunosuppressive Agents; D009173:Mycophenolic Acid