Clinical, histopathologic, and therapeutic aspects of subepidermal autoimmune bullous diseases with IgG on the floor of salt-split skin.
BACKGROUND
About 12% of patients with subepidermal autoimmune bullous disease and immunoglobulin G (IgG) at the dermal-epidermal junction present diseases other than bullous pemphigoid.


METHODS
We report the clinical, histopathologic, and therapeutic aspects of eight cases of subepidermal bullous disorder with IgG on the floor of salt-split skin.


RESULTS
A predominant neutrophilic infiltrate was detected in six of the eight patients. In one patient, the inflammatory infiltrate was neutrophilic and eosinophilic in the same proportion. A good response to dapsone alone or combined with prednisone was observed in six patients.


CONCLUSIONS
The salt-split skin direct immunofluorescence test is useful for its diagnostic and therapeutic implications.
Barnadas
M A
MA
Department of Dermatology and Pathology, Hospital de la Sta. Creu i St Pau, C/St Antoni M Claret, 167, 08025 Barcelona, Spain.
González
M J
MJ
Planagumà
M
M
Romaní
J
J
Curell
R
R
de Moragas
J M
JM
Alomar
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D005260:Female; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000276:immunology / Q000473:pathology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology / Q000473:pathology*
D007074:Immunoglobulin G