title: Pemphigus foliaceus with prominent neutrophilic pustules.
abstract: We describe four patients with generalized scaly and pustular skin lesions showing extensive neutrophilic infiltration in the subcorneal region of the epidermis. Immunofluorescence, immunoblot and enzyme-linked immunosorbent assay analyses detected IgG antibodies reacting exclusively with desmoglein 1, the pemphigus foliaceus antigen. This study indicates that pemphigus foliaceus may show prominent neutrophilic pustular skin lesions.
authors.affiliation: Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
authors.forename: A
authors.initials: A
authors.lastname: Komai
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: Y
authors.initials: Y
authors.lastname: Futei
authors.forename: M
authors.initials: M
authors.lastname: Amagai
authors.forename: H
authors.initials: H
authors.lastname: Deguchi
authors.forename: K
authors.initials: K
authors.lastname: Danno
authors.forename: T
authors.initials: T
authors.lastname: Hashimoto
mesh_terms: D000328:Adult; D000368:Aged; D001324:Autoantigens / Q000276:immunology; D015820:Cadherins / Q000276:immunology; D051183:Desmoglein 1; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D020556:Neutrophil Infiltration; D010392:Pemphigus / Q000276:immunology / Q000473:pathology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology / Q000473:pathology*
chemical_list: D001324:Autoantigens; D015820:Cadherins; D051183:Desmoglein 1; D007070:Immunoglobulin A; D007074:Immunoglobulin G