title: Acid-suppressive therapy use associated with antihypertensive agents.
abstract: Nitrates and calcium channel blockers (CCBs) have been shown to decrease lower esophageal sphincter pressure and theoretically may precipitate or aggravate gastroesophageal reflux. Thus, the authors hypothesized that patients who receive these agents would have greater use of acid-suppressive drug use, defined as histamine2 antagonists or proton pump inhibitors. A retrospective cohort design was used to assess the use of acid-suppressive drug use in hypertensive patients with respect to both nitrates and antihypertensive therapy. Of 15,662 treated hypertensive patients, 20% received acid-suppressive therapy. An increased use of acid-suppressive therapy was associated with nitrate (odds ratio [OR] = 1.71), CCB (OR = 1.46), and alpha 1 antagonist (OR = 1.32) treatment, which appeared to be additive when patients received two or more of the agents. Within the class of CCBs, there was no significant difference among the individual agents. As the clinical and economic burden may be substantial, further study is warranted.
authors.affiliation: School of Pharmacy, University at Buffalo, State University of New York, Buffalo, New York, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Chow
authors.forename: A B
authors.initials: AB
authors.lastname: Luzier
authors.forename: L
authors.initials: L
authors.lastname: DiTusa
authors.forename: B D
authors.initials: BD
authors.lastname: Snyder
authors.forename: J L
authors.initials: JL
authors.lastname: Izzo
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015897:Comorbidity; D004359:Drug Therapy, Combination; D005260:Female; D006279:Health Maintenance Organizations; D006635:Histamine H2 Antagonists / Q000008:administration & dosage*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017891:Pharmacoepidemiology; D012044:Regression Analysis; D012189:Retrospective Studies
chemical_list: D000959:Antihypertensive Agents; D006635:Histamine H2 Antagonists