title: Cold feet and prolonged sleep-onset latency in vasospastic syndrome.
abstract: People with vasospastic syndrome have cold hands and feet and abnormal vasoconstriction after local cold exposure. Normally there is a circadian rhythm of distal vasodilation, with onset in the early evening, which directly influences ability to fall asleep. We gave a sleep questionnaire to 32 patients with primary vasospastic syndrome and 31 healthy controls. People with vasospasticity had significantly prolonged sleep-onset latency both at onset of night-time sleep and after nocturnal disturbance. This prolonged latency could be associated with impaired capacity for distal vasodilation.
authors.forename: M
authors.initials: M
authors.lastname: Pache
authors.forename: K
authors.initials: K
authors.lastname: Kräuchi
authors.forename: C
authors.initials: C
authors.lastname: Cajochen
authors.forename: A
authors.initials: A
authors.lastname: Wirz-Justice
authors.forename: B
authors.initials: B
authors.lastname: Dubler
authors.forename: J
authors.initials: J
authors.lastname: Flammer
authors.forename: H J
authors.initials: HJ
authors.lastname: Kaiser
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D003251:Constriction, Pathologic; D005260:Female; D005528:Foot / Q000098:blood supply*; D006801:Humans; D007035:Hypothermia / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D012307:Risk Factors; D020178:Sleep Disorders, Circadian Rhythm / Q000209:etiology*; D007319:Sleep Initiation and Maintenance Disorders / Q000209:etiology*; D011795:Surveys and Questionnaires; D013577:Syndrome; D014664:Vasodilation