title: Length variation in HV2 of the human mitochondrial DNA control region.
abstract: Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.
authors.affiliation: DNA Analysis Unit II, FBI Laboratory, Washington, DC 20535, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Stewart
authors.forename: C L
authors.initials: CL
authors.lastname: Fisher
authors.forename: P J
authors.initials: PJ
authors.lastname: Aagaard
authors.forename: M R
authors.initials: MR
authors.lastname: Wilson
authors.forename: A R
authors.initials: AR
authors.lastname: Isenberg
authors.forename: D
authors.initials: D
authors.lastname: Polanskey
authors.forename: E
authors.initials: E
authors.lastname: Pokorak
authors.forename: J A
authors.initials: JA
authors.lastname: DiZinno
authors.forename: B
authors.initials: B
authors.lastname: Budowle
mesh_terms: D000595:Amino Acid Sequence; D003596:Cytosine; D004272:DNA, Mitochondrial / Q000235:genetics*; D005554:Forensic Medicine; D014644:Genetic Variation; D006197:Hair / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D004272:DNA, Mitochondrial; D003596:Cytosine