title: Combined mitral valve and coronary artery surgery: ischemic versus non-ischemic mitral valve disease.
abstract: OBJECTIVE
  Mitral valve combined with coronary artery surgery is associated with a higher hospital mortality than each operation in particular. Controversy exists regarding the predictive value of ischemic mitral valve disease (MVD) on outcome.
  
  
  METHODS
  Between 1984 and 1997, 262 patients underwent mitral valve operations (replacement, n = 198; repair, n = 64) in combination with coronary revascularization. The etiology of MVD was secondary to ischemic heart disease (group I) in 82 (31%) patients, and non-ischemic (group II) in 180 (69%) patients (rheumatic, 139 patients (53%); degenerative, 41 patients (16%)). Both groups were similar in age, cardiac risk factors and pulmonary artery pressure. Patients of group I had significantly more severe coronary artery disease, more often an impaired left ventricle and myocardial infarction, and were in a worse functional condition. The mean number of bypass grafts was significantly higher in group I. The follow-up was 98% (230/234 patients).
  
  
  RESULTS
  With 19.5%, the hospital mortality was significantly increased in group I compared with 6.7% in group II (P = 0.002; overall, 10.7%). Mitral valve repair or replacement had no influence on early outcome, although mitral valve repair was performed more often in group I (37 versus 19%). The survival (valve-related event-free survival) after discharge from hospital in the 1st, 5th and 10th year was 94 (94%), 70 (66%) and 53% (35%) in group I and 96 (95%), 79 (76%) and 54% (41%) in group II, respectively. The long-term functional capacity was equally good in both groups (New York Heart Association mean, 1.86 versus 1.72).
  
  
  CONCLUSIONS
  Patients with ischemic MVD are in a worse cardiac condition with significantly higher hospital mortality than patients with non-ischemic MVD and coronary artery bypass grafting. Once discharged from hospital, both groups have comparable long-term outcomes, with the best results in patients with degenerative MVD.
authors.affiliation: Department of Thoracic and Cardiovascular Surgery, University Hospital RWTH Aachen, Pauwelsstrasse 30, G-52074 Aachen, Germany. rseipelt@post.klinikum.rwth-aachen.de
authors.forename: R G
authors.initials: RG
authors.lastname: Seipelt
authors.forename: F A
authors.initials: FA
authors.lastname: Schoendube
authors.forename: J F
authors.initials: JF
authors.lastname: Vazquez-Jimenez
authors.forename: H
authors.initials: H
authors.lastname: Doerge
authors.forename: M
authors.initials: M
authors.lastname: Voss
authors.forename: B J
authors.initials: BJ
authors.lastname: Messmer
mesh_terms: D000368:Aged; D006348:Cardiac Surgical Procedures / Q000401:mortality; D003327:Coronary Disease / Q000150:complications / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D017052:Hospital Mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D011379:Prognosis; D016896:Treatment Outcome