title: Progressive outer retinal necrosis syndrome: successful treatment with a new combination of antiviral drugs.
abstract: OBJECTIVE
  To describe a case of progressive outer retinal necrosis syndrome, successfully treated with a new combination of antiviral drugs.
  
  
  METHODS
  The patient was treated with a combined therapy of antiviral drugs that includes: intravenous acyclovir 10 mg/kg, three intravitreal injections of foscarnet (1200 microg) and a ganciclovir implant in the right eye.
  
  
  RESULTS
  The progressive outer retinal necrosis appeared to response dramatically with the combination of antiviral agents used over a period of 2 weeks with a final visual acuity of 20/80 at 3 months of follow up.
  
  
  CONCLUSIONS
  Intravitreal foscarnet combined with i.v. acyclovir and ganciclovir implant may represent an effective alternative treatment for PORN.
authors.affiliation: Department of Ophthalmology, Hanna Retina Research Center, Storm Eye Institute, Medical University of South Carolina, Charleston 29425-2236, USA.
authors.forename: E A
authors.initials: EA
authors.lastname: Roig-Melo
authors.forename: T A
authors.initials: TA
authors.lastname: Macky
authors.forename: M L
authors.initials: ML
authors.lastname: Heredia-Elizondo
authors.forename: D V
authors.initials: DV
authors.lastname: Alfaro
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D000212:Acyclovir / Q000008:administration & dosage; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D018450:Disease Progression; D004343:Drug Implants; D004359:Drug Therapy, Combination; D015828:Eye Infections, Viral / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D017245:Foscarnet / Q000008:administration & dosage; D015774:Ganciclovir / Q000008:administration & dosage; D006561:Herpes Simplex / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D015882:Retinal Necrosis Syndrome, Acute / Q000188:drug therapy* / Q000473:pathology / Q000821:virology
chemical_list: D000998:Antiviral Agents; D004343:Drug Implants; D017245:Foscarnet; D015774:Ganciclovir; D000212:Acyclovir