title: Early ultrastructural injuries in the thyroid of the normal rat radioinduced by diagnostic and/or therapeutic amounts of iodine-131.
abstract: After irradiation, two principal mechanisms of cytolytic cell death can be involved: apoptosis and necrosis. By using morphological criteria, cells undergoing apoptosis can be distinguished from cells dying by necrosis. In nuclear medicine 131I is used to ablate thyroid remnants or to treat well differentiated thyroid carcinoma. The aim of study was to describe the progressive morphological thyroid changes induced by a diagnostic and/or therapeutic amounts of 131I in the rat using electron microscopy, in an attempt to determine which is the cell death pathway and to analyse "stunned" thyroid tissue to elucidate this effect. Tissular and ultrastructural examinations show that damages induced by 131I irradiation of the normal thyroid gland are heterogeneous. Thyroid cells die by necrosis after this metabolic irradiation, and no signs of apoptosis were observed by electron microscopy. In the other hand, stunning effect did not seem to impair the effectiveness of 131I treatment.
authors.affiliation: Laboratoire de Biophysique, Faculté de Médecine Xavier Bichat, Paris, France. fvitaux@ch-montfermeil.fr
authors.forename: F
authors.initials: F
authors.lastname: Guiraud-Vitaux
authors.forename: G
authors.initials: G
authors.lastname: Feldmann
authors.forename: N
authors.initials: N
authors.lastname: Vadrot
authors.forename: S
authors.initials: S
authors.lastname: Charles-Gupta
authors.forename: A M
authors.initials: AM
authors.lastname: Durand-Schneider
authors.forename: N
authors.initials: N
authors.lastname: Colas-Linhart
authors.forename: A
authors.initials: A
authors.lastname: Petiet
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects; D007457:Iodine Radioisotopes / Q000009:adverse effects; D008297:Male; D009336:Necrosis; D011832:Radiation Injuries / Q000473:pathology*; D011877:Radionuclide Imaging / Q000009:adverse effects*; D011878:Radiotherapy / Q000009:adverse effects*; D051381:Rats; D017208:Rats, Wistar; D013961:Thyroid Gland / Q000473:pathology* / Q000648:ultrastructure*; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes