title: Meiotic recombination and chromosome segregation in Schizosaccharomyces pombe.
abstract: In most organisms homologous recombination is vital for the proper segregation of chromosomes during meiosis, the formation of haploid sex cells from diploid precursors. This review compares meiotic recombination and chromosome segregation in the fission yeast Schizosaccharomyces pombe and the distantly related budding yeast Saccharomyces cerevisiae, two especially tractable microorganisms. Certain features, such as the occurrence of DNA breaks associated with recombination, appear similar, suggesting that these features may be common in eukaryotes. Other features, such as the role of these breaks and the ability of chromosomes to segregate faithfully in the absence of recombination, appear different, suggesting multiple solutions to the problems faced in meiosis.
authors.affiliation: Fred Hutchinson Cancer Research Center, 1100 Fairview Avenue North, A1-162, Seattle, WA 98109-1024, USA.
authors.forename: L
authors.initials: L
authors.lastname: Davis
authors.forename: G R
authors.initials: GR
authors.lastname: Smith
mesh_terms: D000818:Animals; D002842:Chromatids; D020090:Chromosome Segregation; D004249:DNA Damage; D004261:DNA Replication; D004271:DNA, Fungal; D005656:Fungal Proteins / Q000378:metabolism; D015966:Gene Expression Regulation, Fungal; D008540:Meiosis / Q000502:physiology*; D011995:Recombination, Genetic; D012568:Schizosaccharomyces / Q000235:genetics* / Q000502:physiology; D029702:Schizosaccharomyces pombe Proteins; D013573:Synaptonemal Complex; D015534:Trans-Activators
chemical_list: D004271:DNA, Fungal; D005656:Fungal Proteins; D029702:Schizosaccharomyces pombe Proteins; D015534:Trans-Activators; C087051:rep1 protein, S pombe