title: Digestive hemorrhage caused by a Meckel's diverticulum in a metformin-treated patient: is there any connection?
abstract: An obese patient, not diabetic, treated with metformin for some weeks, was referred to us with severe inferior digestive hemorrhage, diagnosed with Meckel's diverticulum. Metformin is described as a glucose-lowering agent for treatment of type 2 diabetes mellitus and as antiobesity drug, though results achieved with this last indication are not conclusive. But metformin has fibrinolytic features by means of diminished plasminogen activator inhibitor 1 activity. Although no coagulation study was done and the Meckel's diverticulum is normally associated with bleeding, the particular intensity of the following hemorrhage may have been favored by metformin.
authors.affiliation: Servicio de Farmacia, Hospital Universitario del Mar, Paseo Marítimo 25-29, 08003, Barcelona, Spain. 88544@imas.imim.es
authors.forename: M A
authors.initials: MA
authors.lastname: Burrull-Madero
authors.forename: A
authors.initials: A
authors.lastname: Del-Villar-Ruiz
authors.forename: S
authors.initials: S
authors.lastname: Grau-Cerrato
authors.forename: M
authors.initials: M
authors.lastname: Andreu-Garcia
authors.forename: A
authors.initials: A
authors.lastname: Goday-Arno
mesh_terms: D000328:Adult; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000150:complications*; D006801:Humans; D007004:Hypoglycemic Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008467:Meckel Diverticulum / Q000139:chemically induced / Q000150:complications*; D008687:Metformin / Q000009:adverse effects / Q000627:therapeutic use; D009765:Obesity / Q000188:drug therapy
chemical_list: D007004:Hypoglycemic Agents; D008687:Metformin