title: Postoperative stroke in cardiac surgery is related to the location and extent of atherosclerotic disease in the ascending aorta.
abstract: OBJECTIVE
  The aim of the study was to evaluate the risk from calcified atheromas in the ascending aorta, and the extent and topography of the disease in the development of stroke after cardiac surgery.
  
  
  BACKGROUND
  Postoperative stroke constitutes a serious problem in cardiac surgery, and atherosclerosis of the ascending aorta is an important risk factor.
  
  
  METHODS
  Before surgical manipulation epiaortic echocardiographic ultrasound was performed to evaluate the ascending aorta in 921 consecutive patients undergoing cardiac surgery. The presence of calcification, location of atheroma, extent of the disease and clinical variables including postoperative stroke were recorded prospectively.
  
  
  RESULTS
  A total of 26.2% of the patients had atherosclerosis of the ascending aorta, and in 44.4% of them more than one of 12 possible segments was involved. Logistic regression showed that atherosclerotic disease in the ascending aorta was the most important predictive factor for postoperative stroke. The incidence of stroke was 1.8% in patients without atherosclerotic disease of the ascending aorta, and 8.7% in patients with the disease (p < 0.0001). Diabetes mellitus was also a predictive factor (p = 0.04). A new and unique finding of this study was that the middle-lateral segment is an independent predictive factor for postoperative stroke, with a relative risk of 26% (p = 0.04).
  
  
  CONCLUSIONS
  Patients with atheromatosis in the ascending aorta had an 8.7% incidence of postoperative stroke, in spite of minor surgical modifications. The risk depended on the presence, location and extent of the disease. Randomized trials evaluating alternative surgical strategies in coronary surgery are urgently needed in high risk patients.
authors.affiliation: Department of Cardiothoracic Surgery and Anesthesiology, Huddinge University Hospital, Stockholm, Sweden. jan.vanderlinden@thsurg.hs.sll.se
authors.forename: J
authors.initials: J
authors.lastname: van der Linden
authors.forename: L
authors.initials: L
authors.lastname: Hadjinikolaou
authors.forename: P
authors.initials: P
authors.lastname: Bergman
authors.forename: D
authors.initials: D
authors.lastname: Lindblom
mesh_terms: D001018:Aortic Diseases / Q000150:complications*; D001161:Arteriosclerosis / Q000150:complications*; D006348:Cardiac Surgical Procedures / Q000009:adverse effects*; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D020521:Stroke / Q000209:etiology*