Pleiotropic functions and tissue-specific expression of erythropoietin.
Erythropoietin (EPO) is produced in the brain, uterus, and oviduct. Brain EPO plays a neuroprotective role, and uterine EPO is likely involved in estrogen-dependent angiogenesis. Hypoxic induction of brain EPO markedly differs from that in the kidney. EPO in the uterus and oviduct is estrogen inducible.
Sasaki
R
R
Division of Integrated Life Science, Graduate School of Biostudies, Kyoto University, Kyoto 606-8502, Japan.
Masuda
S
S
Nagao
M
M
D000818:Animals; D001921:Brain / Q000378:metabolism; D004921:Erythropoietin / Q000502:physiology*; D006801:Humans; D018919:Neovascularization, Physiologic / Q000502:physiology; D018696:Neuroprotective Agents; D017467:Receptors, Erythropoietin / Q000378:metabolism
D018696:Neuroprotective Agents; D017467:Receptors, Erythropoietin; D004921:Erythropoietin