NC-1500 prevents concanavalin A-induced mice hepatitis without affecting cytokine gene expression.
NC-1500 is a dihydropyridine type calcium channel blocker. The effect of NC-1500 on mice concanavalin A-induced hepatitis was examined. Treatment of mice with concanavalin A (Con A) caused elevation of plasma transaminase. Pretreatment of mice with NC-1500 (3, 10 and 30 mg/kg, p.o.) prevented this Con A-induced elevation of plasma transaminase. Treatment of mice with Con A induced tumor necrosis factor-alpha (TNF-alpha) mRNA expression in the liver. However, NC-1500 (30 mg/kg, p.o.) did not affect this Con A-induced TNF-alpha mRNA expression in the liver. The present results showed that NC-1500 inhibited Con A-induced hepatitis without affecting TNF-alpha mRNA expression in the liver.
Okamoto
T
T
Research Laboratories, Nippon Chemiphar Co., Ltd., Misato, Saitama 341-0005, Japan.
Kobayashi
T
T
Jeong
S Y
SY
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001219:Aspartate Aminotransferases / Q000097:blood; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000494:pharmacology*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000276:immunology* / Q000517:prevention & control; D003208:Concanavalin A / Q000009:adverse effects; D004095:Dihydropyridines / Q000008:administration & dosage / Q000494:pharmacology*; D004195:Disease Models, Animal; D005260:Female; D015870:Gene Expression / Q000187:drug effects*; D019695:Glycyrrhizic Acid / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009287:Naphthyridines / Q000008:administration & dosage / Q000494:pharmacology*; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D009287:Naphthyridines; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; C056825:Goe 5438; D003208:Concanavalin A; D019695:Glycyrrhizic Acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase