[The study of immune effect of nine kinds of recombinant hepatitis B vaccines made in China and foreign countries].
OBJECTIVE
To study the immune effect of nine kinds of recombinant hepatitis B (FIB) vaccines.


METHODS
Immunizing 715 primary school children with four genetically engineered FIB vaccines of 12 batches that were yeast HB vaccine (YDV), Chinese hamster ovary cell HB vaccine (CHO), vaccinia derived vaccine and Hansenula Polymorpha vaccine produced by USA MSD Co, USA Amgen Co, Japan, France, Argentina and Beijing, Changchun, Shenzhen of China. The anti-HBs was tested by RIA (Abbott reagent).


RESULTS
Four kinds of genetically engineered HB vaccines were safe and effective. The peak of the antibody after immunization with Chinese vaccines appeared at the 7th month of the first dose. The geometric mean titre (GMT) of the anti-HBs was higher (393.60 mIU/ml) after immunized by vaccinia derived vaccine, its stability was better than the batches of CHO. The antibody titer descended in a narrow range after immunization of YDV. The vaccine containing 10 microg/dose was superior to 5 microg/dose in antibody persistence. Hansenuly polymorpha vaccine was the first time to study in China, it showed a good immune effect.


CONCLUSIONS
The total immune effect of the recombinant FIB vaccines made no distinction among the products of China and USA, Japan, France and Argentina.
Jing
Q
Q
Kaifeng Liver Disease Research Institute, Henan, Kaifeng 475000, China.
Ren
L
L
Wang
J
J
D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000517:prevention & control*; D006510:Hepatitis B Antibodies / Q000097:blood; D017325:Hepatitis B Vaccines / Q000276:immunology*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology*
D006510:Hepatitis B Antibodies; D017325:Hepatitis B Vaccines; D014614:Vaccines, Synthetic