title: Roles of homocysteine in cell metabolism: old and new functions.
abstract: Mild hyperhomocysteinemia has been suggested as a new, independent risk factor for cardiovascular disease. This fact has produced a new, increased interest in the study of homocysteine metabolism and its relation to pathogenesis. This emergent area of biomedical research is reviewed here, stressing the biochemical and metabolic basis of the pathogenicity of increased levels of homocysteine.
authors.affiliation: Departamento de Biología Molecular y Bioquímica, Facultad de Ciencias, Universidad de Málaga, Spain. medina@uma.es
authors.forename: M
authors.initials: M
authors.lastname: Medina
authors.forename: J L
authors.initials: JL
authors.lastname: Urdiales
authors.forename: M I
authors.initials: MI
authors.lastname: Amores-Sánchez
mesh_terms: D002318:Cardiovascular Diseases / Q000209:etiology; D002468:Cell Physiological Phenomena; D005260:Female; D006710:Homocysteine / Q000378:metabolism*; D006801:Humans; D020138:Hyperhomocysteinemia / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D008715:Methionine / Q000378:metabolism; D008745:Methylation; D009421:Nervous System Malformations / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D012436:S-Adenosylmethionine / Q000378:metabolism
chemical_list: D012346:RNA, Transfer, Amino Acyl; D006710:Homocysteine; D012436:S-Adenosylmethionine; D008715:Methionine