The morphological effects of a radio frequency lesion adjacent to the dorsal root ganglion (RF-DRG)--an experimental study in the goat.
Radiofrequency (RF) lesions adjacent to the dorsal root ganglion (DRG) are increasingly used in the treatment of intractable chronic pain of spinal origin. Opinions differ on which nerve fibres are affected by these lesions. Morphological studies have been carried out to assess the effects of radiofrequency lesions on nervous tissue. Interpretation has been difficult, since most studies have been performed under circumstances which are not comparable to the clinical situation. This study was undertaken to investigate morphological effects of RF lesions as they develop in the normal clinical situation. In two goats 22 G 100 mm SMK electrodes with a 5 mm active tip (Radionics) were positioned posterior to the lumber dorsal root ganglia (DRG). Sixty-second 67;C lesions were made on one side. The contralateral side was used as sham operation. The goats were sacrificed 2 weeks after the procedure. The lesions were studied for size as well as for effects on proliferation and regeneration using Ki-67 (MIB-1). Lesions made inside the DRG (23) were 1.8-2.0 mm in size. In these lesions there was a total loss of myelinated fibres. In lesions made adjacent to the DRG there was a significantly higher MIB-1 labelling on the treated side as compared to the sham-treated side. An RF lesion inside the DRG destroys myelinated fibres. A lesion adjacent to the DRG increases MIB-1 activity, indicating proliferation and regeneration after 2 weeks, despite the fact that the lesion was made outside the ganglion.
de Louw
A J
AJ
Department of Neurology, University Hospital Maastricht, PO Box 5800, Maastricht, The Netherlands. adl@sneu.azm.nl
Vles
H S
HS
Freling
G
G
Herpers
M J
MJ
Arends
J W
JW
Kleef
M
M
D000273:Adipose Tissue / Q000473:pathology; D000818:Animals; D034961:Antigens, Nuclear; D017115:Catheter Ablation; D002455:Cell Division; D005727:Ganglia, Spinal / Q000737:chemistry / Q000473:pathology*; D006041:Goats; D006651:Histocytochemistry; D019394:Ki-67 Antigen; D009336:Necrosis; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009687:Nuclear Proteins / Q000032:analysis; D059408:Pain Management; D013116:Spinal Cord / Q000473:pathology
D034961:Antigens, Nuclear; D019394:Ki-67 Antigen; D009687:Nuclear Proteins