Tetrasomy 21 as the sole acquired karyotypic abnormality in acute myeloblastic leukemia.
Peripheral blood and bone marrow analysis of a 79-year-old female led to a diagnosis of acute myeloblastic leukemia with differentiation (AML-M2). Chromosome analysis of the unstimulated bone marrow cells revealed 48, XX,+21,+21, and tetrasomy 21 was the sole cytogenetic abnormality in this constitutionally normal female patient.
Odagaki
T
T
Section of Internal Medicine, Kobe Kyodo Hospital, 2-Kubo-cho, Nagata-ku, 653-0041, Kobe, Japan.
Sugimoto
T
T
Matsuo
M
M
Tatsumi
E
E
Saigo
K
K
D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000235:genetics*