title: Management of primary cutaneous melanoma of the head and neck: The University of Colorado experience and a review of the literature.
abstract: BACKGROUND
  While elective lymph node dissection (ELND), adjuvant radiation therapy and sentinel lymph node biopsy have all been advocated in the routine management of primary cutaneous melanoma arising in the head and neck, the optimal management has not been defined.
  
  
  METHODS
  We have reviewed our experience of 273 patients with primary melanoma of the head and neck entered into a prospective database at the University of Colorado Health Sciences Center (UCHSC) from 1978 through 1998 and contrasted this with other reports in the literature.
  
  
  RESULTS
  A total of 168 patients were identified that received their initial management at UCHSC and had no clinical evidence of distant disease. Only nine patients (5%) underwent ELND, and no patients received adjuvant radiation therapy. The local recurrence rate and 5-year melanoma specific survival, according to Breslow thickness, were similar to centers where adjuvant radiation therapy or ELND are routinely performed. Our preliminary experience and a review of the literature suggests that the technique of sentinel lymph node biopsy is an accurate and low risk procedure that provides valuable prognostic information useful in the further management of these patients.
  
  
  CONCLUSIONS
  There is no clear indication that either ELND or adjuvant radiation therapy impacts on the outcome of patients with primary melanoma of the head and neck. Sentinel lymph node biopsy, in appropriate cases, is becoming the standard of care.
authors.affiliation: Department of Medicine, Division of Medical Oncology, University of Colorado Health Sciences Center, Colorado, USA.
authors.forename: P
authors.initials: P
authors.lastname: Gibbs
authors.forename: W A
authors.initials: WA
authors.lastname: Robinson
authors.forename: N
authors.initials: N
authors.lastname: Pearlman
authors.forename: D
authors.initials: D
authors.lastname: Raben
authors.forename: P
authors.initials: P
authors.lastname: Walsh
authors.forename: R
authors.initials: R
authors.lastname: Gonzalez
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006258:Head and Neck Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008545:Melanoma / Q000532:radiotherapy / Q000601:surgery*; D008875:Middle Aged; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000532:radiotherapy / Q000601:surgery*; D016896:Treatment Outcome