Signaling pathways activated by the growth hormone receptor.
In recent years, significant progress has been made in elucidating the signaling pathways activated by the growth hormone (GH) receptor. An initiating event is probably the activation of JAK2 (Janus kinase 2), a GH receptor-associated tyrosine kinase. Identification of the proteins recruited to the GH receptor-JAK2 complex and dissection of the signaling pathways that are subsequently activated will ultimately provide a basis for understanding GH action at the molecular level.
Herrington
J
J
Dept Physiology, University of Michigan Medical School, Ann Arbor, MI 48109, USA.
Carter-Su
C
C
D000818:Animals; D004789:Enzyme Activation; D019382:Human Growth Hormone / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D053614:Janus Kinase 2; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011518:Proto-Oncogene Proteins; D011986:Receptors, Somatotropin / Q000502:physiology*; D015398:Signal Transduction
D011518:Proto-Oncogene Proteins; D011986:Receptors, Somatotropin; D019382:Human Growth Hormone; D011505:Protein-Tyrosine Kinases; C507924:JAK2 protein, human; D053614:Janus Kinase 2