Peptides from pinto bean and red bean with sequence homology to cowpea 10-kDa protein precursor exhibit antifungal, mitogenic, and HIV-1 reverse transcriptase-inhibitory activities.
Peptides with a molecular weight of 5 kDa have been isolated from seeds of the pinto bean and red bean, respectively. The peptides manifest an N-terminal sequence with remarkable resemblance to those of cowpea 10-kDa protein precursor and garden pea disease resistance response protein. The bean peptides possess potent antifungal activity toward a variety of fungal species including Botrytis cinerea, Mycosphaerella arachidicola, and Fusarium oxysporum. The proteins also demonstrate mitogenic activity toward mouse splenocytes and an inhibitory action on HIV-1 reverse transcriptase.
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Department of Biochemistry, Chinese University of Hong Kong, Shatin, Hong Kong, China. biochemistry @cuhk.edu.hk
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D000595:Amino Acid Sequence; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D001203:Ascomycota / Q000187:drug effects; D020171:Botrytis / Q000187:drug effects; D002478:Cells, Cultured; D002681:China; D002852:Chromatography, Ion Exchange; D007887:Fabaceae / Q000737:chemistry*; D005670:Fusarium / Q000187:drug effects; D054303:HIV Reverse Transcriptase / Q000037:antagonists & inhibitors*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D008970:Molecular Weight; D018532:Pisum sativum; D010455:Peptides / Q000737:chemistry* / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D014176:Protein Biosynthesis / Q000187:drug effects; D011817:Rabbits; D012156:Reticulocytes / Q000187:drug effects; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology*; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D013154:Spleen / Q000166:cytology; D014481:United States
D000935:Antifungal Agents; D010455:Peptides; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase