[Antioxidative state and lipid peroxidation in erectile dysfunction: preliminary study].
OBJECTIVE
The aims of this study were to analyze the cavernosal tissue metabolic status of patients with vascular and psychogenic impotence and attempt to establish metabolic differences between these types of erectile dysfunction.


METHODS
103 patients were classified according to the type of erectile dysfunction into group A (vascular) and group B (psychogenic). Diagnosis was based on clinical history, physical examination, intracavernosal injection test, penile echo-doppler assessment, cavernosography-cavernosometry and nocturnal penile test. Cavernosal and peripheral venous blood samples were obtained from each patient and the lipoperoxide (LPO) levels and total antioxidant status (TAS) were determined. SPSS V9.0 was used for the statistical analysis.


RESULTS
The mean age was 62 years (range 32-73). Cavernosal blood lipoperoxide levels were statistically higher (p < 0.05) in patients with vascular impotence (2.45 mumol/L) than in those with psychogenic impotence (1.47 mumol/L). Cavernosal blood total antioxidant status was statistically higher (p < 0.05) in patients with psychogenic (1.40 mmol/L) than those with vascular impotence (1.10 mmol/L). The lipoperoxide levels and total antioxidant status for peripheral blood were 1.68 mumol/L vs 1.60 mumol/L and 1.29 mmol/L vs 1.35 mmol/L, respectively, with no statistically significant differences between both groups.


CONCLUSIONS
Cavernosal blood lipoperoxide levels and total antioxidant status can be an indicator of cavernosal tissue metabolic status and function.
Fernández-Arjona
M
M
Departamento de Urología, Hospital Santa Bárbara, Puertollano, Ciudad Real. mfvd@eresmas.com
Díaz
J
J
Carbonell
L
L
Oteros
R
R
Zarca
M A
MA
Cortés
I
I
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D007172:Erectile Dysfunction / Q000378:metabolism*; D006801:Humans; D015227:Lipid Peroxidation; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D008875:Middle Aged
D000975:Antioxidants; D008054:Lipid Peroxides