title: Incomplete gastric metaplasia in children with insulin-dependent diabetes mellitus and celiac disease. An ultrastructural study.
abstract: BACKGROUND: The association of insulin-dependent diabetes mellitus (IDDM) and celiac disease (CD) has been widely reported in children but the relationship between the two conditions is incompletely understood. Moreover, specific studies on intestinal biopsies of patients with the association of the two diseases are still lacking. METHODS: We studied the ultrastructure of the duodenal mucosa in 12 patients with both IDDM and CD. RESULTS: All patients had either total or partial atrophy of duodenal mucosa. In seven subjects, an accumulation of electrondense granules in the apical cytoplasm of groups of enterocytes was found. In four of them, a double population of granules existed (mean diameter: 400-800 nm and 100-200 nm respectively) showing a biphasic pattern. In the other three patients, only smaller granules (100- 200 nm) were found in the enterocytes. CONCLUSIONS: The present work suggests that patients with IDDM/CD may represent a subgroup in the context of the CD population. Intestinal biopsies of such individuals often show accumulation of electrondense granules in the apical cytoplasm of enterocytes that can be interpreted as incomplete gastric metaplasia.
authors.affiliation: Institute of Anatomy and Histology University of Verona, Verona, Italy. sbarbati@borgoroma.univr.it
authors.forename: Marina
authors.initials: M
authors.lastname: Bertini
authors.forename: Andrea
authors.initials: A
authors.lastname: Sbarbati
authors.forename: Enrico
authors.initials: E
authors.lastname: Valletta
authors.forename: Leonardo
authors.initials: L
authors.lastname: Pinelli
authors.forename: Luciano
authors.initials: L
authors.lastname: Tatò