Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.
Dinsmore
C J
CJ
Bogusky
M J
MJ
Culberson
J C
JC
Bergman
J M
JM
Homnick
C F
CF
Zartman
C B
CB
Mosser
S D
SD
Schaber
M D
MD
Robinson
R G
RG
Koblan
K S
KS
Huber
H E
HE
Graham
S L
SL
Hartman
G D
GD
Huff
J R
JR
Williams
T M
TM
D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D004791:Enzyme Inhibitors; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I; D051231:Farnesyltranstransferase