Comparison of effects of ioxaglate versus iomeprol on histamine and tryptase release in patients with ischemic cardiomyopathy.
We observed a release of histamine, but not of tryptase, in arterial blood from 64 patients with ischemic heart disease and 24 patients without coronary disease, which was provoked by ioxaglate, a ionic compound, but was not provoked by iomeprol, a non-ionic radiocontrast compound. The release of histamine in arterial blood after ionic contrast medium injection was higher in patients with ischemic heart disease compared with patients without coronary disease, suggesting that an increased release from heart mast cells previously observed exists also for systemic blood basophils.
Rodriguez
R M
RM
Service de Cardiologie, CHU de Nancy-Brabois, Vandoeuvre, France. rossyrod@club-internet.fr
Guéant
J L
JL
Gastin
I A
IA
Angioi
M
M
Abdelmoutaleb
I
I
Saint-Laudy
J
J
Gérard
P
P
Namour
F
F
Grentzinger
A
A
Romano
A
A
Juillière
Y
Y
Danchin
N
N
D001491:Basophils / Q000276:immunology; D016022:Case-Control Studies; D003287:Contrast Media / Q000494:pharmacology*; D017023:Coronary Angiography; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D007479:Iopamidol / Q000031:analogs & derivatives* / Q000276:immunology; D007485:Ioxaglic Acid / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000276:immunology*; D011446:Prospective Studies; D012697:Serine Endopeptidases / Q000378:metabolism*; D053802:Tryptases
D003287:Contrast Media; D018836:Inflammation Mediators; C057937:iomeprol; D012697:Serine Endopeptidases; D053802:Tryptases; D007479:Iopamidol; D007485:Ioxaglic Acid