Hypoplastic left heart and postaxial polydactyly.
Two siblings are presented with hypoplastic left heart syndrome and symmetrical postaxial polydactyly affecting upper and lower limbs. This association has not been previously documented. This appears to represent a newly recognized syndrome. The inheritance is likely to be autosomal recessive, but other inheritance patterns cannot be excluded at present.
Brennan
P
P
Department of Clinical Genetics, City Hospital, Nottingham, UK.
D000015:Abnormalities, Multiple / Q000235:genetics / Q000473:pathology*; D005192:Family Health; D017809:Fatal Outcome; D005808:Genes, Recessive; D006801:Humans; D018636:Hypoplastic Left Heart Syndrome / Q000235:genetics / Q000473:pathology*; D007231:Infant, Newborn; D008297:Male; D017689:Polydactyly / Q000235:genetics / Q000473:pathology*