Micronuclei in peripheral blood lymphocytes and buccal epithelial cells of Polish farmers exposed to pesticides.
In this biomonitoring study, we investigated whether an occupational exposure to a complex mixture of chemical pesticides produced a significant increase of micronuclei (MN) in both peripheral blood lymphocytes and buccal cells. Forty-nine male workers exposed to pesticides, from an agricultural area of Malopolska Region in Southern Poland, together with 50 men from the same area without indication of exposure to pesticides that served as controls, were used in this investigation. No statistically significant differences in the frequencies of cytogenetic damage were detected between exposed and control individuals, for either type of cells. The multiple linear regression analysis in the case of lymphocytes indicated that the studied cytogenetic endpoints were inversely influenced by alcohol; whilst a negative binomial regression, in the case of buccal cells, indicated that the MN values were directly influenced by the ingestion of red meat. An inverse negative relationship between the cytokinesis-block proliferation index and age, and a significant increase of miscarriages due to the exposure to pesticides were also observed.
Pastor
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S
Grup de Mutagènesi, Departament de Genètica i de Microbiologia, Facultat de Ciències, Edifici Cn, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain.
Gutiérrez
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S
Creus
A
A
Cebulska-Wasilewska
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A
Marcos
R
R
D000022:Abortion, Spontaneous / Q000139:chemically induced; D000328:Adult; D000383:Agriculture; D002478:Cells, Cultured; D015986:Confounding Factors, Epidemiologic; D004032:Diet; D004784:Environmental Monitoring; D004848:Epithelium / Q000187:drug effects*; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D008019:Life Style; D008297:Male; D015162:Micronucleus Tests; D009061:Mouth Mucosa / Q000166:cytology / Q000187:drug effects; D016273:Occupational Exposure / Q000009:adverse effects*; D010575:Pesticides / Q000009:adverse effects*; D011044:Poland; D012307:Risk Factors
D010575:Pesticides