Synthesis of lipid A type pyran carboxylic acids with ether chains and their biological activities.
Synthesis of lipid A type pyran carboxylic acids having ether chains at both the C-3' and C-4 positions and their bioactivities toward human U937 cells are described.
Watanabe
Y
Y
Exploratory Chemistry Research Laboratories, Sankyo Co. Ltd., Hiromachi 1-2-58, Shinagawa-ku, Tokyo 140-8710, Japan.
Mochizuki
T
T
Shiozaki
M
M
Kanai
S
S
Kurakata
S
S
Nishijima
M
M
D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004987:Ethers / Q000138:chemical synthesis / Q000494:pharmacology; D006801:Humans; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D020128:Inhibitory Concentration 50; D008050:Lipid A / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D011714:Pyrans / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000187:drug effects; D020298:U937 Cells / Q000187:drug effects
D002264:Carboxylic Acids; D004987:Ethers; D007166:Immunosuppressive Agents; D008050:Lipid A; D008070:Lipopolysaccharides; D011714:Pyrans; D014409:Tumor Necrosis Factor-alpha