Association between polymorphisms in candidate genes and morbid obesity.
Polymorphisms in a number of candidate genes have been reported to be associated with obesity. We have determined the incidence of the following polymorphisms in the following candidate genes in a group of 388 morbid obese patients (mean body mass index (BMI) 52+/-8.01) who underwent gastric banding surgery: lipoprotein lipase (LpL) t-93 g and N291S; peroxisome proliferator receptor gamma (PPARgamma), P12A, P115Q and c1431t; peroxisome proliferator receptor alpha (PPARalpha) L162V; beta-adrenergic receptor 2 (beta-AR 2), Q27E; beta-adrenergic receptor 3 (beta-AR 3) W64R; uncoupling protein 1 (ucp-1), a-3826g, ucp-2, 45 bp insertion. Only for the ucp2 polymorphism did we find a statistically significant association with obesity. The beta-AR 3 W64R and ucp-1 a-3826g polymorphisms influenced the rate of the development of obesity and may act synergistically.
Evans
D
D
Medizinische Klinik, Universitätskrankenhaus Eppendorf, Martinistrasse 52, 20251 Hamburg, Germany. evans@uke.uni-hamburg.de
Wolf
A M
AM
Nellessen
U
U
Ahle
S
S
Kortner
B
B
Kuhlmann
H W
HW
Beisiegel
U
U
D000328:Adult; D015992:Body Mass Index; D001835:Body Weight / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D007473:Ion Channels; D008297:Male; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D009767:Obesity, Morbid / Q000235:genetics*; D011110:Polymorphism, Genetic; D011506:Proteins; D000071246:Uncoupling Protein 2
D002352:Carrier Proteins; D007473:Ion Channels; D026901:Membrane Transport Proteins; D024101:Mitochondrial Proteins; D011506:Proteins; C000604389:UCP2 protein, human; D000071246:Uncoupling Protein 2