Efficacy of high dose steroid therapy in children with severe acute transverse myelitis.
No effective treatment has been demonstrated for patients with acute transverse myelopathy. In a multicentre controlled study, 12 children with severe acute transverse myelopathy were treated with intravenous methylprednisolone (IVMP) and compared with a historical group of 17 patients. The treatment had a significant effect on the proportion of patients walking independently at 1 month and on the proportion with full recovery at 1 year, with no differences in the frequency of complications between the two groups.
Defresne
P
P
Service de Neurologie, Département de Pédiatrie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Bruxelles, Belgium. pierre.defresne@freebel.net
Meyer
L
L
Tardieu
M
M
Scalais
E
E
Nuttin
C
C
De Bont
B
B
Loftus
G
G
Landrieu
P
P
Kadhim
H
H
Sébire
G
G
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000009:adverse effects; D009188:Myelitis, Transverse / Q000188:drug therapy*
D008775:Methylprednisolone