[Polymethylene derivatives of nucleic bases with omega-functional groups. II. Adenine and hypoxanthine derivatives].
N9-Polymethylene derivatives of adenine and hypoxanthine with various functional groups in the omega-position of the alkyl substituent were synthesized. Their physico-chemical properties and effect on the HIV reverse transcriptase and DNA topoisomerase I were studied.
Makinskiĭ
A A
AA
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, GSP-1 Moscow, 119991 Russia.
Kritsyn
A M
AM
Ul'ianova
E A
EA
Zakharova
O D
OD
Bugreev
D V
DV
Nevinskiĭ
G A
GA
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000478:Alkylation; D004264:DNA Topoisomerases, Type I / Q000187:drug effects; D054303:HIV Reverse Transcriptase / Q000187:drug effects; D006838:Hydrocarbons; D019271:Hypoxanthine / Q000138:chemical synthesis / Q000494:pharmacology; D007042:Hypoxanthines; D008697:Methane / Q000031:analogs & derivatives*
D006838:Hydrocarbons; D007042:Hypoxanthines; C030011:carbene; D019271:Hypoxanthine; D054303:HIV Reverse Transcriptase; D004264:DNA Topoisomerases, Type I; D000225:Adenine; D008697:Methane