Interaction between delta-9-tetrahydrocannabinol and indomethacin.
The effect of indomethacin on the Delta9-tetrahydrocannabinol (Delta9-THC)-induced fall in rabbit intraocular pressure (IOP) was determined. A 2% suspension of indomethacin was given topically 1 h before intravenous injection of Delta9-THC. IOP was measured hourly and was compared between groups receiving either Delta9-THC alone or Delta9-THC plus indomethacin. A substantial attenuation of the IOP response to Delta9-THC was caused by indomethacin. Delta9-THC may influence IOP at least in part by a prostaglandin-mediated process. Involvement of the cyclooxygenase pathway offers a common explanation for linking several ocular cannabinoid effects. The latter include a fall in IOP, conjunctival hyperemia and minor inflammation.
Green
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K
Department of Ophthalmology, Medical College of Georgia, Augusta, GA 30912-3400, USA. kgreen@mail.mcg.edu
Kearse
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McIntyre
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D000287:Administration, Topical; D000818:Animals; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D013759:Dronabinol / Q000494:pharmacology*; D004347:Drug Interactions; D007213:Indomethacin / Q000494:pharmacology*; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects*; D009883:Ophthalmic Solutions; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011817:Rabbits
D016861:Cyclooxygenase Inhibitors; D009883:Ophthalmic Solutions; D011619:Psychotropic Drugs; D013759:Dronabinol; D007213:Indomethacin