title: New paeonilactone-A adducts formed by anaerobic incubation of paeoniflorin with Lactobacillus brevis in the presence of arylthiols.
abstract: During the course of preparing anticonvulsant paeonimetabolin-I adducts, new paeonilactone-A adducts: 9-phenylthiopaeonilactone-A, 9-(o-tolylthio)paeonilactone-A, 9-(m-tolylthio)paeonilactone-A, 9-(p-tolylthio)-paeonilactone-A and 9-(2-naphthylthio)paeonilactone-A, were obtained along with expected paeonimetabolin-I adducts by anaerobic incubation of paeoniflorin from peony roots with Lactobacillus brevis in the presence of the aromatic thiols, phenylthiol, o-tolylthiol, m-tolylthiol, p-tolylthiol and 2-naphthylthiol. The structures of these compounds were determined by spectroscopic methods including two dimensional (2D) NMR.
authors.affiliation: Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, Sugitani, Japan.
authors.forename: A A
authors.initials: AA
authors.lastname: Abdel-Hafez
authors.forename: M R
authors.initials: MR
authors.lastname: Meselhy
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Hattori
authors.forename: M A
authors.initials: MA
authors.lastname: El-Gendy
authors.forename: N M
authors.initials: NM
authors.lastname: Mahfouz
authors.forename: T A
authors.initials: TA
authors.lastname: Mohamed
mesh_terms: D000693:Anaerobiosis; D001565:Benzoates; D001952:Bridged-Ring Compounds; D002240:Carbohydrate Sequence; D002855:Chromatography, Thin Layer; D005960:Glucosides / Q000378:metabolism*; D007202:Indicators and Reagents; D007778:Lactobacillus / Q000378:metabolism*; D007783:Lactones / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D039821:Monoterpenes; D029596:Paeonia / Q000737:chemistry; D013055:Spectrophotometry, Infrared; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D006027:Glycosides
chemical_list: D001565:Benzoates; D001952:Bridged-Ring Compounds; D005960:Glucosides; D007202:Indicators and Reagents; D007783:Lactones; D039821:Monoterpenes; D013438:Sulfhydryl Compounds; C408125:paeonilactone A; C015423:peoniflorin; D006027:Glycosides