title: Determination of Ki-67 labeling index in pituitary adenomas using MIB-1 monoclonal antibody.
abstract: Proliferative activity of 94 pituitary adenomas was assessed by the determination of the growth fraction, using MIB-1 monoclonal antibody in formalin fixed, paraffin embedded sections. This index was correlated with clinical and radiological evidence of invasiveness. The mean Ki-67 labeling index for all pituitary adenomas was 0.84% (range 0-17.45%). Hardy stage E tumours (1.44%) had a higher Ki-67 labeling index (LI) as compared with Hardy stage 0 tumours (0.36%). The difference in the Ki-67 labeling indices between invasive and non-invasive adenomas was not statistically significant. Hence, the Ki-67 labeling index is not a reliable indicator of invasiveness in pituitary adenomas.
authors.affiliation: Department of Neurological Sciences, Christian Medical College and Hospital, Vellore, 632 004, India.
authors.forename: R
authors.initials: R
authors.lastname: Lath
authors.forename: G
authors.initials: G
authors.lastname: Chacko
authors.forename: M J
authors.initials: MJ
authors.lastname: Chandy
mesh_terms: D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D002648:Child; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D019394:Ki-67 Antigen