title: Does the estrogen receptor gene polymorphism relate to undefined menopausal symptoms?
abstract: The present study examines the relationship between estrogen receptor (ER) gene polymorphism and undefined complaints to clarify the aging process of the genitospinal center. Pvu II and Xba I restriction fragment length polymorphism (RFLP) of the estrogen receptor (ER) gene and its relationships to undefined symptoms was examined in 507 Japanese peri- and postmenopausal women who were classified in 3 groups by serum estradiol (E2) values; group A:E2>30 pg/ml; group B:E210-30 pg/ml; group C:E2<10 pg/ml. The percentage of women grouped A was significantly higher than that of group B in genotype Pp. Furthermore, the frequency of Ppxx in group A was significantly higher than that of group B or C. On the other hand, the frequency of ppxx in group A was significantly lower than that of group B (p=0.0042) or C (p=0.049). Neither FSH nor LH differed significantly between Ppxx and ppxx. On the other hand, the plasma estradiol level differed significantly between Ppxx and ppxx (p=0.0004). Moreover, a higher incidence of mental symptoms was observed in group A than in groups B or C (p<0.01). The present results suggest that ER gene polymorphism influences aging of the genitospinal center, and may explain in part the pathophysiology and cause of undefined perimenopausal complaints.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka Medical College, Takatsuki, Japan. gyn003@poh.osaka-med.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Ushiroyama
authors.forename: M
authors.initials: M
authors.lastname: Heishi
authors.forename: A
authors.initials: A
authors.lastname: Ikeda
authors.forename: M
authors.initials: M
authors.lastname: Ueki
mesh_terms: D000273:Adipose Tissue; D000375:Aging / Q000235:genetics; D015992:Body Mass Index; D004247:DNA / Q000235:genetics / Q000302:isolation & purification; D017931:DNA Primers; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008593:Menopause / Q000235:genetics* / Q000523:psychology; D008875:Middle Aged; D011110:Polymorphism, Genetic / Q000235:genetics* / Q000502:physiology*; D017698:Postmenopause / Q000235:genetics / Q000502:physiology / Q000523:psychology; D011960:Receptors, Estrogen / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D017931:DNA Primers; D006062:Gonadotropins; D011960:Receptors, Estrogen; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D004247:DNA