title: Butyrylcholinesterase in lumbar and ventricular cerebrospinal fluid.
abstract: OBJECTIVE
  This study establishes reference data for human lumbar CSF butyrylcholinesterase (E.C.3.1.1.8.) activity and investigates the enzyme activity in ventricular CSF. We comment on the relationship between CSF butyrylcholinesterase activity and other laboratory parameters.
  
  
  METHODS
  We investigated 64 lumbar CSF samples obtained from a clinically healthy population and 169 ventricular CSF samples collected from 90 neurosurgical patients.
  
  
  RESULTS
  The reference range we recommend for lumbar CSF butyrylcholinesterase activity is 5.4 to 17.0 nmol/min x ml. The majority of ventricular butyrylcholinesterase activities in our patient subset ranged up to 5 nmol/min x ml.
  
  
  CONCLUSIONS
  We established the relative influence of serum and CNS components on total CSF butyrylcholinesterase activity. The CNS fraction predominates the total butyrylcholinesterase activity in normal lumbar CSF. In ventricular CSF enzyme influx from serum outweighs the CNS component.
authors.affiliation: Clinic of Orthopaedics, "Rudolf Elle" Hospital Eisenberg, Friedrich-Schiller University Jena, Germany. wolframkluge@compuserve.com
authors.forename: W H
authors.initials: WH
authors.lastname: Kluge
authors.forename: H H
authors.initials: HH
authors.lastname: Kluge
authors.forename: A
authors.initials: A
authors.lastname: Hochstetter
authors.forename: R
authors.initials: R
authors.lastname: Vollandt
authors.forename: H I
authors.initials: HI
authors.lastname: Bauer
authors.forename: R
authors.initials: R
authors.lastname: Venbrocks
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002091:Butyrylcholinesterase / Q000134:cerebrospinal fluid*; D002552:Cerebral Ventricles / Q000201:enzymology*; D005260:Female; D006801:Humans; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D012016:Reference Values
chemical_list: D002091:Butyrylcholinesterase