Dendritic cell development from common myeloid progenitors.
Dendritic cells (DCs) are professional antigen-presenting cells which both initiate adaptive immune responses and control tolerance to self-antigens. It has been suggested that these different effects on responder cells depend on subsets of DCs arising from either myeloid or lymphoid hematopoietic origins. In this model, CD8 alpha+ Mac-1- DCs are supposed to be of lymphoid while CD8 alpha- Mac-1+ DCs are supposed to be of myeloid origin. Here we summarize our findings that both CD8 alpha+ and CD8 alpha- DCs can arise from clonogenic common myeloid progenitors (CMPs) in both thymus and spleen. Therefore CD8 alpha expression DCs does not indicate a lymphoid origin and differences among CD8 alpha+ and CD8 alpha- DCs might rather reflect maturation status than ontogeny. On the basis of transplantation studies, it seems likely that most of the DCs in secondary lymphoid organs and a substantial fraction of thymic DCs are myeloid-derived.
Manz
M G
MG
Department of Pathology and Developmental Biology, B261 Beckman Center, Stanford University School of Medicine, 279 Campus Drive, Stanford, California 94305-5428, USA. manz@stanford.edu
Traver
D
D
Akashi
K
K
Merad
M
M
Miyamoto
T
T
Engleman
E G
EG
Weissman
I L
IL
D000818:Animals; D000943:Antigens, Differentiation / Q000032:analysis; D001854:Bone Marrow Cells / Q000166:cytology; D016827:CD8 Antigens / Q000032:analysis; D002454:Cell Differentiation; D019070:Cell Lineage; D002999:Clone Cells / Q000166:cytology; D003713:Dendritic Cells / Q000145:classification / Q000166:cytology*; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D016177:Macrophage-1 Antigen / Q000032:analysis; D051379:Mice; D022423:Myeloid Cells / Q000166:cytology*; D011828:Radiation Chimera; D013950:Thymus Gland / Q000166:cytology; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000502:physiology
D000943:Antigens, Differentiation; D016827:CD8 Antigens; D016177:Macrophage-1 Antigen; D014157:Transcription Factors