[Analysis of hormone profile in women during the pre- and postmenopausal period using hormone replacement therapy, and analysis of the mammography image in these women].
The hormonal profile and mammography results were analysed in 120 women in premenopause (group A) and 130 in postmenopausal period (group B). The analysis developed biphasic menstrual cycle, with high progesterone levels in the second cycle's period in 57 subjects (group A--mean P concentration--53.7 nmol/ml), and elevated E2 levels in monophasic cycle in 63 subjects (group A2--man E2 205.4 pg/dl). In case of post-menopausal women mean E2 level during therapy was 104.6 pg/dl. In examined group 8 subject have been undergoing hormonal replacement therapy for 1-3 years, 30 of them for 5 years, 20 more than 5 years. In mammography in one case from group A1 with high progesterone concentration abnormally opaqueness has been observed. Histological examination confirmed incidence of cancer cells. No other changes have been observed. High serum progesterone concentration in pre-menopausal women increase risk of cancer.
Niesłuchowska-Frydrych
B
B
I Katedry i Kliniki Połoznictwa i Ginekologii AM w Warszawie.
Dworniak
T
T
Iwaszkiewicz
K
K
Marianowski
L
L
D000328:Adult; D001943:Breast Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging* / Q000473:pathology; D004967:Estrogens / Q000097:blood*; D005260:Female; D020249:Hormone Replacement Therapy / Q000009:adverse effects*; D006801:Humans; D008327:Mammography; D008875:Middle Aged; D017698:Postmenopause / Q000097:blood; D017697:Premenopause / Q000097:blood; D011374:Progesterone / Q000097:blood*; D018570:Risk Assessment
D004967:Estrogens; D011374:Progesterone