title: Corneal topographical study of the effect of lacrimal punctum occlusion on corneal surface regularity in dry eye patients.
abstract: OBJECTIVE
  To compare topographic indices of surface regularity in dry eye patients and in normal subjects (controls) and to investigate the short-term effect of lacrimal punctal plugs on these indices in dry eye patients.
  
  
  METHODS
  The surface regularity index (SRI) and surface asymmetry index (SAI) of the TMS-2 corneal topographic modelling system were used to evaluate corneal surface regularity in 20 eyes of 10 dry eye patients before and after the insertion of Herrick silicon lacrimal plugs (Lacrimedics, Rialto, CA, USA) and in 24 eyes of 12 normal subjects as controls.
  
  
  RESULTS
  SRI and SAI were significantly lower in controls than dry eye patients (p=0.00). Median SRI was 1.72 in dry eye patients before punctal occlusion and 0.525 in the control group. Median SAI was 1.305 in dry eye patients and 0.240 in controls. After lacrimal punctal occlusion, Schirmer test results and fluorescein breakup time increased in nine patients and remained the same in one patient. After occlusion, the SRI decreased in 9 eyes, and increased in 11 (p=0.970); SAI decreased in 13 eyes and increased in 7 (p=0.135).
  
  
  CONCLUSIONS
  No significant change in topographic indices of corneal surface irregularity could be detected in severe dry eye patients with lacrimal punctal plugs in the short-term follow-up.
authors.affiliation: Department of Ophthalmology, Hacettepe University Hospital, Ankara, Turkey.
authors.forename: Y
authors.initials: Y
authors.lastname: Ozkan
authors.forename: B
authors.initials: B
authors.lastname: Bozkurt
authors.forename: S
authors.initials: S
authors.lastname: Gedik
authors.forename: M
authors.initials: M
authors.lastname: Irkeç
authors.forename: M
authors.initials: M
authors.lastname: Orhan
mesh_terms: D001672:Biocompatible Materials; D003315:Cornea / Q000033:anatomy & histology* / Q000378:metabolism; D019781:Corneal Topography; D015352:Dry Eye Syndromes / Q000378:metabolism / Q000601:surgery*; D005260:Female; D015590:Fluorophotometry; D006801:Humans; D007765:Lacrimal Apparatus / Q000601:surgery*; D008297:Male; D019736:Prostheses and Implants; D019919:Prosthesis Implantation; D012826:Silicone Elastomers; D013666:Tears / Q000378:metabolism
chemical_list: D001672:Biocompatible Materials; D012826:Silicone Elastomers