title: Pregnancy and perinatal complications associated with risks for common psychiatric disorders in a population-based sample of female twins.
abstract: The association between pregnancy and perinatal complications (PPCs) and risks for adult psychiatric disorders other than psychoses has received relatively limited attention. In this study, we aim to characterize the associations between PPCs and risks for anxiety, affective, substance use, and eating disorders in a population-based sample of twins. Personal interviews were conducted with 1,806 female twin subjects to assess their lifetime history of alcoholism, anorexia nervosa, bulimia nervosa, generalized anxiety disorder, major depression, panic disorder, simple phobias, and social phobias. PPCs were retrospectively assessed at personal interview with the subject's parents. The associations between PPCs and risks for psychiatric disorders are characterized using logistic regression. In this sample of twins, gestational age is associated with a significantly increased risk for anorexia nervosa and pregnancy complications are associated with a significantly increased risk for both anorexia nervosa and bulimia nervosa. Pregnancy and perinatal complications may be associated with an increased risk for eating disorders in women.
authors.affiliation: Department of Human Genetics, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, Virginia 23298-0003, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Foley
authors.forename: L R
authors.initials: LR
authors.lastname: Thacker
authors.forename: S H
authors.initials: SH
authors.lastname: Aggen
authors.forename: M C
authors.initials: MC
authors.lastname: Neale
authors.forename: K S
authors.initials: KS
authors.lastname: Kendler
mesh_terms: D000328:Adult; D000437:Alcoholism; D000855:Anorexia; D001007:Anxiety; D003627:Data Interpretation, Statistical; D003863:Depression; D005192:Family Health; D001068:Feeding and Eating Disorders; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D016584:Panic Disorder; D011247:Pregnancy; D011248:Pregnancy Complications; D015995:Prevalence; D012042:Registries / Q000706:statistics & numerical data; D012307:Risk Factors; D014768:Virginia / Q000453:epidemiology