Inhibition of fucosyltransferase V by a GDP-Azasugar.
A GDP-azasugar conjugate was synthesized starting from an enzymatically obtained phosphorylated azasugar. It inhibits human fucosyltransferase V at micromolar concentrations, which is discussed in terms of transition state analogy.
Schuster
M
M
Institut für Organische Chemie, Sekr. C3, Technische Universität Berlin, Strasse des 17. Juni 135, D-10623, Berlin, Germany. mschuster@chem.tu-berlin.de
Blechert
S
S
D001665:Binding Sites / Q000502:physiology; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000737:chemistry*; D005647:Fucosyltransferases / Q000037:antagonists & inhibitors*; D006153:Guanosine Diphosphate / Q000031:analogs & derivatives / Q000737:chemistry* / Q000494:pharmacology*; D020128:Inhibitory Concentration 50
D002241:Carbohydrates; D006153:Guanosine Diphosphate; D005647:Fucosyltransferases; C435083:fucosyltransferase V