[Urokinase stimulates whereas tissue plasminogen activator attenuates blood vessel stenosis].
Periadventitial application of the urokinase-plasminogen activator (uPA) in pluronic gel to an injured artery stimulated the neointima and neoadventitia formation as well as cell migration and proliferation in vivo. In contrast, the tissue-type plasminogen activator (tPA) reduced the number of neointimal smooth muscle cells and neointimal area and attenuated the lumen stenosis after a balloon catheter injury of the rat carotid artery. This ability to stimulate the neointima and neoadbentitia formation was found to be quite specific for the uPA. The findings suggest that this uPA property provides a specific functional target for attenuating growth of the damage.
Plekhanova
O S
OS
Cardiology Research Centre, 121552, 3rd Cherepkovskaya St., 15a, Moscow, Russia.
Solomatina
M A
MA
Domogatskiĭ
S P
SP
Naumov
V G
VG
Tkachuk
V A
VA
Parfenova
E V
EV
Chazov
E I
EI
D000800:Angioplasty, Balloon; D000818:Animals; D017536:Carotid Artery, Common / Q000378:metabolism / Q000473:pathology*; D016893:Carotid Stenosis / Q000378:metabolism / Q000473:pathology*; D002455:Cell Division; D002465:Cell Movement; D007150:Immunohistochemistry; D051381:Rats; D011921:Rats, Inbred WKY; D011994:Recombinant Proteins / Q000494:pharmacology; D010959:Tissue Plasminogen Activator / Q000378:metabolism* / Q000494:pharmacology; D017539:Tunica Intima / Q000473:pathology; D017540:Tunica Media / Q000473:pathology; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism* / Q000494:pharmacology
D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator