title: Radiofrequency ablation for eradication of pulmonary tumor in rabbits.
abstract: BACKGROUND
  Radiofrequency ablation (RFA) has emerged as an alternative for surgery in clinical oncology. This animal experiment was conducted to evaluate the feasibility of RFA in the treatment of pulmonary tumor.
  
  
  METHODS
  Eighteen rabbits with pulmonary implantation of VX2 tumors were divided into two groups. Group A (n = 12) was treated with RFA by using a cooled-tip electrode technique. Group B (n = 6) received sham operation. The therapeutic efficacy was evaluated by survival rate, magnetic resonance imaging (MRI), postmortem microangiography, and histology.
  
  
  RESULTS
  All animals in group B died within 3 months after tumor implantation. Tumor eradication was achieved in 9 of 12 rabbits (75.0%) in group A, of which 4 rabbits survived longer than 3 months free of disease and another 5 rabbits were found free of viable tumor when sacrificed. One rabbit was subjected to incomplete tumor ablation and two rabbits suffered from local tumor relapse and/or lung metastasis. The 3-month survival rate of RFA-treated rabbits was significantly higher (P < 0.01) than that of control rabbits. The typical MRI appearances of the acute RFA lesion consisted of five characteristic concentric zones, which corresponded to central needle track (zone A), tumor coagulation (zone B), pulmonary parenchyma coagulation (zone C), peripheral hemorrhage (zone D), and inflammatory layer (zone E) on histology.
  
  
  CONCLUSIONS
  Eradication of pulmonary tumor could be achieved with current RFA technique in rabbits. MRI is a useful modality for assessment of lung tumor ablation.
authors.affiliation: Department of Radiology, University Hospitals, Catholic University of Leuven, Herestraat 49, B-3000 Leuven, Belgium.
authors.forename: Y
authors.initials: Y
authors.lastname: Miao
authors.forename: Y
authors.initials: Y
authors.lastname: Ni
authors.forename: H
authors.initials: H
authors.lastname: Bosmans
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: J
authors.initials: J
authors.lastname: Vaninbroukx
authors.forename: S
authors.initials: S
authors.lastname: Dymarkowski
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Marchal
mesh_terms: D000792:Angiography; D000818:Animals; D017115:Catheter Ablation; D008168:Lung / Q000098:blood supply / Q000473:pathology / Q000601:surgery; D008175:Lung Neoplasms / Q000473:pathology / Q000601:surgery*; D008279:Magnetic Resonance Imaging; D008297:Male; D008833:Microcirculation; D019060:Minimally Invasive Surgical Procedures; D011817:Rabbits