title: Nematode-antagonistic trichothecenes from Fusarium equiseti.
abstract: A strain of the fungus Fusarium equiseti isolated from soybean cyst nematode secretes nematode-antagonistic compounds. Bioassay-guided fractionation of an extract of the culture broth was undertaken to identify the compounds. Fractions were assayed for activity against a root-knot nematode (Meloidogyne incognita), a plant pathogen that attacks the roots of numerous plant species. Two trichothecene compounds were isolated that inhibited egg hatch and immobilized second-stage juveniles of this nematode: 4,15-diacetoxy-12,13-epoxy-3,7-dihydroxytrichothec-9-en-8-one (4,15-diacetylnivalenol) and 4,15-diacetoxy-12,13-epoxy-trichothec-9-en-3-ol (diacetoxyscirpenol). This is the first published report of these compounds affecting plant-parasitic nematodes.
authors.affiliation: Nematology Laboratory, USDA, ARS, Beltsville, Maryland 20705-2350, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Nitao
authors.forename: S L
authors.initials: SL
authors.lastname: Meyer
authors.forename: W F
authors.initials: WF
authors.lastname: Schmidt
authors.forename: J C
authors.initials: JC
authors.lastname: Fettinger
authors.forename: D J
authors.initials: DJ
authors.lastname: Chitwood
mesh_terms: D000818:Animals; D001681:Biological Assay; D004531:Eggs; D005670:Fusarium / Q000737:chemistry*; D006790:Host-Parasite Interactions; D007814:Larva; D010571:Pest Control; D010944:Plants; D014255:Trichothecenes / Q000009:adverse effects / Q000494:pharmacology*; D014431:Tylenchoidea / Q000187:drug effects*
chemical_list: D014255:Trichothecenes