Feedback control of a biodynamical model of HIV-1.
We describe a continuous differential equation model of the interaction dynamics of HIV-1 and CD4 and CD8 lymphocytes in the human body. We demonstrate several methods of stable control of the HIV-1 population using an external feedback control term that is analogous to the introduction of a therapeutic drug regimen. We also show how the immune system components can be bolstered against the virus through a feedback control approach.
Brandt
M E
ME
Neurosignal Analysis Laboratory, School of Health Information Sciences, University of Texas Health Science Center, Houston 77030, USA. Michael.E.Brandt@uth.tmc.edu
Chen
G
G
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000821:virology*; D019380:Anti-HIV Agents / Q000008:administration & dosage*; D016516:CD4-CD8 Ratio; D018450:Disease Progression; D005246:Feedback; D015497:HIV-1 / Q000472:pathogenicity*; D006207:Half-Life; D006801:Humans; D008954:Models, Biological; D017711:Nonlinear Dynamics; D019562:Viral Load
D019380:Anti-HIV Agents