title: Patency following successful thrombolysis of occluded vascular grafts.
abstract: OBJECTIVE
  to determine patency after successful lysis of occluded bypass grafts.
  
  
  METHODS
  data were collected from four centres with a wide experience of thrombolysis. Outcome following successful lysis was determined from prospectively collected data or case notes. Data from 75 patients, 53 men, were analysed.
  
  
  RESULTS
  median age at time of lysis was 68 years (range 33-88). Median age of graft was 12 months (range 1-120). Patency at 12 months was 33% (95% conf. interval: 21-44%). There were no differences in patency depending on whether the graft was above or below the inguinal ligament or whether an additional procedure eg. percutaneous or vein patch angioplasty was carried out. However in those 48 cases when lysis was deemed complete, i.e. there was restoration of graft patency and at least one vessel run off patency at 12 months was 39% compared with 17% if lysis was incomplete (p=0.04).
  
  
  CONCLUSIONS
  at the present time it is difficult to justify routine thrombolysis of occluded grafts when patency, based on intention to treat, is approximately 20% at one year. Following successful graft lysis the role of anticoagulation and careful graft surveillance require further investigation.
authors.affiliation: Department of Surgery, Royal Berkshire Hospital, Reading.
authors.forename: R B
authors.initials: RB
authors.lastname: Galland
authors.forename: T R
authors.initials: TR
authors.lastname: Magee
authors.forename: B
authors.initials: B
authors.lastname: Whitman
authors.forename: J J
authors.initials: JJ
authors.lastname: Earnshaw
authors.forename: C
authors.initials: C
authors.lastname: Judge
authors.forename: G
authors.initials: G
authors.lastname: Hamilton
authors.forename: M
authors.initials: M
authors.lastname: Kerle
authors.forename: J H
authors.initials: JH
authors.lastname: Wolfe
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000188:drug therapy*; D006801:Humans; D007511:Ischemia / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015912:Thrombolytic Therapy