Hypotensive reactions associated with transfusion of bedside leukocyte-reduction filtered blood products in heart transplanted patients.
Severe hypotensive reactions that occur during transfusions of blood products to non-transplanted patients were recently linked to the use of bedside leukocyte-reduction filters, sometimes in association with angiotensin-converting enzyme (ACE) inhibitor treatment. We present the first report of such reactions in patients who underwent orthotopic heart transplantation. Fourteen (47%) of the 30 transfused patients experienced severe hypotensive reaction during filtered transfusion of at least 1 unit of blood product, with a total of 24 episodes. Eleven (79%) of these patients were treated pre-operatively with ACE inhibitors.
Lavee
J
J
Heart Transplantation Unit, Department of Cardiac Surgery, Sheba Medical Center, Tel-Hashomer, Israel.
Paz
Y
Y
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D001803:Blood Transfusion / Q000379:methods* / Q000706:statistics & numerical data; D001920:Bradykinin / Q000097:blood / Q000187:drug effects; D017707:Erythrocyte Transfusion / Q000009:adverse effects; D005374:Filtration / Q000379:methods; D016027:Heart Transplantation / Q000706:statistics & numerical data; D006801:Humans; D007022:Hypotension / Q000453:epidemiology* / Q000209:etiology* / Q000628:therapy; D015994:Incidence; D017708:Leukocyte Transfusion / Q000009:adverse effects / Q000379:methods / Q000706:statistics & numerical data; D017713:Platelet Transfusion / Q000009:adverse effects; D011292:Premedication; D065227:Transfusion Reaction
D000806:Angiotensin-Converting Enzyme Inhibitors; D001920:Bradykinin