title: A test of amino acid reversibility.
abstract: In studies of molecular evolution, the assumption that protein evolution is reversible has often been made, but rarely tested. Here we use a large set of orthologous murid protein coding sequences to perform a simple test of reversibility, and find no evidence to reject the assumption of reversibility in protein evolution.
authors.affiliation: Centre for the Study of Evolution and School of Biological Sciences, University of Sussex, Brighton, BN1 9QG, United Kingdom. n.g.c.smith@sussex.ac.uk
authors.forename: N G
authors.initials: NG
authors.lastname: Smith
authors.forename: A
authors.initials: A
authors.lastname: Eyre-Walker
mesh_terms: D019943:Amino Acid Substitution / Q000235:genetics; D000818:Animals; D016009:Chi-Square Distribution; D019295:Computational Biology; D006224:Cricetinae; D019143:Evolution, Molecular; D005849:Gerbillinae; D016013:Likelihood Functions; D051379:Mice; D008957:Models, Genetic; D016296:Mutagenesis / Q000235:genetics*; D011506:Proteins / Q000737:chemistry* / Q000235:genetics; D051381:Rats
chemical_list: D011506:Proteins