Design of remarkably simple, yet potent urea-based inhibitors of glutamate carboxypeptidase II (NAALADase).
Kozikowski
A P
AP
Nan
F
F
Conti
P
P
Zhang
J
J
Ramadan
E
E
Bzdega
T
T
Wroblewska
B
B
Neale
J H
JH
Pshenichkin
S
S
Wroblewski
J T
JT
D000818:Animals; D001921:Brain / Q000201:enzymology; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D018690:Excitatory Amino Acid Agonists; D043425:Glutamate Carboxypeptidase II; D016202:N-Methylaspartate; D009457:Neuroglia / Q000166:cytology / Q000187:drug effects; D018696:Neuroprotective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship; D014508:Urea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
D004791:Enzyme Inhibitors; D018690:Excitatory Amino Acid Agonists; D018696:Neuroprotective Agents; D016202:N-Methylaspartate; D014508:Urea; D002268:Carboxypeptidases; D043425:Glutamate Carboxypeptidase II