title: Cardiorespiratory interactions in neural circulatory control in humans.
abstract: The reflex mechanisms and interactions described in this overview provide some explanation for the range of neural circulatory responses evident during changes in breathing. The effects described represent the integrated responses to activation of several reflex mechanisms, including peripheral and central chemoreflexes, arterial baroreflexes, pulmonary stretch receptors, and ventricular mechanoreceptors. These interactions occur on a dynamic basis and the transfer characteristics of any single interaction are, in all likelihood, also highly dynamic. Nevertheless, it is only by attempting to understand individual reflexes and their modulating influences that a more thorough understanding of the responses to complex phenomena such as hyperventilation, apnea, and obstructive sleep apnea can be better understood.
authors.affiliation: Divisions of Hypertension and Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic and Mayo Foundation, 200 First Street SW, Rochester, MN 55905, USA.
authors.forename: A S
authors.initials: AS
authors.lastname: Shamsuzzaman
authors.forename: V K
authors.initials: VK
authors.lastname: Somers
mesh_terms: D017704:Baroreflex / Q000502:physiology; D001775:Blood Circulation / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000502:physiology; D006321:Heart / Q000502:physiology*; D006801:Humans; D009424:Nervous System Physiological Phenomena; D012018:Reflex / Q000502:physiology; D012120:Respiration Disorders / Q000503:physiopathology; D012143:Respiratory Physiological Phenomena