Abnormal brachial artery flow-mediated vasodilation in young adults with major depression.
Depressive illness in patients without traditional risk factors for coronary artery disease is associated with striking abnormalities of endothelial function and elevation of circulating markers of atherosclerosis propensity. Further studies are needed to define the mechanisms that underlie these observations.
Rajagopalan
S
S
Department of Medicine, University of Michigan School of Medicine, Ann Arbor, Michigan, USA. srajagop@umich.edu
Brook
R
R
Rubenfire
M
M
Pitt
E
E
Young
E
E
Pitt
B
B
D000328:Adult; D001916:Brachial Artery / Q000503:physiopathology*; D016022:Case-Control Studies; D018932:Chemokine CCL2 / Q000032:analysis; D003327:Coronary Disease / Q000453:epidemiology; D003866:Depressive Disorder / Q000503:physiopathology*; D019040:E-Selectin / Q000032:analysis; D004730:Endothelium, Vascular / Q000503:physiopathology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000503:physiopathology; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D008297:Male; D012307:Risk Factors; D019010:Vascular Cell Adhesion Molecule-1 / Q000032:analysis; D014664:Vasodilation / Q000502:physiology*
D018932:Chemokine CCL2; D019040:E-Selectin; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1