title: [Induction by ethanol of 'phenomenon of switching estrogen effect' and its correction].
abstract: Drinking of 5% ethanol in combination with estradiol induced genotoxic (G) changes in the rat uterine tissue. The changes could be prevented by N-acetylcysteine or melatonin. The data obtained suggest that ascorbic acid and alpha-tocopherol may be recommended in combination with N-acetylcysteine for repair of estrogen effect switching phenomenon.
authors.affiliation: Petrov Research Institute of Oncology, 189646, St. Petersburg, Pesochny-2, Russia.
authors.forename: L M
authors.initials: LM
authors.lastname: Bershteĭn
authors.forename: E V
authors.initials: EV
authors.lastname: Tsyrlina
authors.forename: T E
authors.initials: TE
authors.lastname: Poroshina
authors.forename: N V
authors.initials: NV
authors.lastname: Bychkova
authors.forename: N M
authors.initials: NM
authors.lastname: Kalinina
authors.forename: V B
authors.initials: VB
authors.lastname: Gamaiunova
authors.forename: O G
authors.initials: OG
authors.lastname: Kriuchkova
authors.forename: I G
authors.initials: IG
authors.lastname: Kovalenko
authors.forename: D A
authors.initials: DA
authors.lastname: Vasil'ev
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology; D000428:Alcohol Drinking / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D002336:Carnosine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D020552:Comet Assay; D004249:DNA Damage; D004958:Estradiol / Q000633:toxicity*; D005260:Female; D008550:Melatonin / Q000494:pharmacology; D010052:Ovariectomy; D051381:Rats; D013550:Swimming; D014599:Uterus / Q000473:pathology; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D004958:Estradiol; D002336:Carnosine; D008550:Melatonin; D001205:Ascorbic Acid; D000111:Acetylcysteine