T cell signaling mechanisms that regulate HIV-1 infection.
The ability of human immunodeficiency virus type-1 (HIV-1) to establish a persistent infection is critically dependent on the cellular signals that regulate HIV-1 replication within target cells. The balance between numerous host factors that either enhance or suppress viral infection determines the clinical outcome. Perturbation of the steady-state level of viral replication can significantly influence the course and the speed at which the infection develops into clinical disease. Activation signals delivered to T cells by cytokines and antigen-presenting cells (APC), are key modulators of viral replication. Our laboratory seeks to decipher how HIV-1 exploits T cell signaling mechanisms and host factors that regulate viral replication. Elucidation of the molecular mechanisms by which cellular signals regulate the HIV-1 life cycle within target cells will significantly advance our understanding of host-virus interactions.
Unutmaz
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Vanderbilt University Medical School, Department of Microbiology and Immunology, Nashville, TN 31232, USA. derya.unutmaz@mcmail.vanderbilt.edu
D000938:Antigen-Presenting Cells / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology / Q000821:virology; D015815:Cell Adhesion Molecules; D016207:Cytokines / Q000502:physiology; D003713:Dendritic Cells / Q000276:immunology; D015693:Gene Products, nef / Q000502:physiology; D015658:HIV Infections / Q000276:immunology / Q000821:virology; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D007156:Immunologic Memory; D037102:Lectins / Q000502:physiology; D037181:Lectins, C-Type; D008213:Lymphocyte Activation; D008221:Lymphoid Tissue / Q000276:immunology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*; D016176:T-Lymphocyte Subsets / Q000502:physiology* / Q000821:virology; D014779:Virus Replication / Q000502:physiology*; D054311:nef Gene Products, Human Immunodeficiency Virus; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D016207:Cytokines; D015693:Gene Products, nef; D037102:Lectins; D037181:Lectins, C-Type; D011956:Receptors, Cell Surface; D054311:nef Gene Products, Human Immunodeficiency Virus; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin