title: Nutritional regulation of lipid metabolism in human adipose tissue.
abstract: Pfeiffer and colleagues years ago pointed out that different distributions and amounts of adipose tissue are associated with abnormalities of lipolysis and lipoprotein metabolism. Adipose tissue has several crucial roles including (i) mobilization from stores of fatty acids as an energy source, (ii) catabolism of lipoproteins such as very-low-density lipoprotein and (iii) synthesis and release of hormonal signals such as leptin and interleukin-6. These adipose tissue actions are crucially regulated by nutrition. The review considers the existence of metabolic pathways and modes of regulation within adipose tissue, and how such metabolic activity can be quantitated in humans. Nutrition can influence adipose tissue at several 'levels'. Firstly the level of obesity or malnutrition has important effects on many aspects of adipose tissue metabolism. Secondly short-term overfeeding, underfeeding and exercise have major impacts on adipose tissue behaviour. Lastly, specific nutrients are capable of regulating adipose tissue metabolism. Recently there have been considerable advances in understanding adipose tissue metabolism and in particular its regulation. This review discusses the behaviour of adipose tissue under various nutritional conditions. There is then a review of recent work examining the ways in which nutritional influences act via intra-cellular mechanisms, insulin and the sympathetic innervation of adipose tissue.
authors.affiliation: St. Bartholomew's & The Royal London School of Medicine, Whitechapel, London, United Kingdom. s.w.coppack@mds.qmw.ac.vk
authors.forename: S W
authors.initials: SW
authors.lastname: Coppack
authors.forename: J N
authors.initials: JN
authors.lastname: Patel
authors.forename: V J
authors.initials: VJ
authors.lastname: Lawrence
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D015444:Exercise / Q000502:physiology; D005215:Fasting / Q000378:metabolism; D006801:Humans; D006946:Hyperinsulinism / Q000378:metabolism; D050356:Lipid Metabolism; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000378:metabolism; D019518:Postprandial Period