title: Variation in genetic and environmental influences in serum lipid and apolipoprotein levels across the lifespan in Swedish male and female twins.
abstract: The contribution of genetic and environmental factors to variation in lipids and apolipoproteins has been estimated in previous twin and family studies. However, it is unclear whether there are sex and/or age differences in parameter estimates. We investigated a sample selected from the population-based Swedish Twin Registry of 725 like- and unlike-sex twin pairs, ages 17-85. Quantitative genetic methods were used to evaluate sex and age differences in genetic and environmental variation in lipid and apolipoprotein levels in three age groups, 17-49, 50-69, and 70-85. Heritabilities for lipids and apolipoproteins ranged from 35%-74%. Consistent sex differences were found in triglycerides. Females had higher heritabilities (56%) than males (35%) across the age groups. Total phenotypic variation increased across the age groups for cholesterol and apolipoprotein B due to an increase in unique environmental variance components. In contrast, in apolipoprotein A1 variance was highest in the middle age group and no differences were found in the phenotypic variance between age groups for triglycerides. We concluded that differences in phenotypic variation for cholesterol and apolipoprotein B were almost entirely due to the accumulation of environmental experiences throughout life, whereas there were no consistent patterns of differences in phenotypic variance for apolipoprotein A1 and triglycerides.
authors.affiliation: Department of Medical Epidemiology, Karolinska Institute, Stockholm, Sweden. anastasia.iliadou@mep.ki.se
authors.forename: A
authors.initials: A
authors.lastname: Iliadou
authors.forename: P
authors.initials: P
authors.lastname: Lichtenstein
authors.forename: U
authors.initials: U
authors.lastname: de Faire
authors.forename: N L
authors.initials: NL
authors.lastname: Pedersen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016632:Apolipoprotein A-I / Q000097:blood; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004777:Environment; D005260:Female; D014644:Genetic Variation; D006801:Humans; D008055:Lipids / Q000097:blood*; D008136:Longevity / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D013223:Statistics as Topic; D013548:Sweden; D014280:Triglycerides / Q000097:blood; D014429:Twins, Dizygotic / Q000235:genetics; D014430:Twins, Monozygotic / Q000235:genetics
chemical_list: D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001055:Apolipoproteins B; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol