Comparison of anorganic bovine mineral with and without synthetic peptide in a sinus elevation: a case study.
A new tissue-engineered bone substitute that reportedly has the capability to enhance bone regeneration over the more classical bone substitutes, such as decalcified freeze-dried bone allograft and xenograft, was evaluated in bilateral sinus procedures. Anorganic bone mineral with and without a synthetic peptide (P-15) were grafted separately in bilateral sinuses. At the time of implant placement and at four months, trephine cores were obtained and the quality of the grafts deciphered by histomorphometry. The P-15 grafted sinus yielded 45% vital bone compared with 13% for the anorganic bovine material alone. The P-15 dramatically increased the quality and quantity of grafted bone in the sinus.
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D000328:Adult; D000818:Animals; D001861:Bone Regeneration / Q000187:drug effects*; D018786:Bone Substitutes; D016025:Bone Transplantation / Q000379:methods*; D002417:Cattle; D002448:Cell Adhesion / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008437:Maxilla / Q000601:surgery; D008443:Maxillary Sinus / Q000601:surgery*; D013516:Oral Surgical Procedures, Preprosthetic / Q000379:methods*; D010446:Peptide Fragments / Q000494:pharmacology*
D018786:Bone Substitutes; D010446:Peptide Fragments; C407062:cell-binding peptide P-15; D003094:Collagen