title: Radiotherapy for genital extramammary Paget's disease in situ.
abstract: BACKGROUND
  Radiotherapy as a first-choice treatment for extramammary Paget's (EMP) disease in situ has been seldom used.
  
  
  OBJECTIVE
  To review the most relevant aspects of radiotherapy as first-choice treatment in selected cases of anogenital EMP disease in situ.
  
  
  METHODS
  Two men with an age range of 71-79 years (mean age 75 +/- 5.6 years) with EMP disease in situ localized in the genital region were treated by means of X-rays of 100 kV, 440 cGy/day, 3 days a week over 3 weeks until a total dose of 3960 cGy was completed.
  
  
  RESULTS
  Complete regression of EMP disease in situ was observed in both patients after radical radiation therapy and neither local recurrences nor internal malignancies have been documented.
  
  
  CONCLUSIONS
  Radiotherapy is a curative treatment in selected cases of EMP disease in situ affecting large areas of the anogenital region.
authors.affiliation: Department of Dermatology, Hospital Clinic, University of Barcelona, Villaroel 170, 08036 Barcelona, Spain.
authors.forename: G A
authors.initials: GA
authors.lastname: Moreno-Arias
authors.forename: C
authors.initials: C
authors.lastname: Conill
authors.forename: A
authors.initials: A
authors.lastname: Castells-Mas
authors.forename: M
authors.initials: M
authors.lastname: Arenas
authors.forename: R
authors.initials: R
authors.lastname: Grimalt
mesh_terms: D000368:Aged; D005837:Genitalia, Male; D006801:Humans; D008297:Male; D010145:Paget Disease, Extramammary / Q000473:pathology / Q000532:radiotherapy*; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D016896:Treatment Outcome