title: Efficacy of high dose steroid therapy in children with severe acute transverse myelitis.
abstract: No effective treatment has been demonstrated for patients with acute transverse myelopathy. In a multicentre controlled study, 12 children with severe acute transverse myelopathy were treated with intravenous methylprednisolone (IVMP) and compared with a historical group of 17 patients. The treatment had a significant effect on the proportion of patients walking independently at 1 month and on the proportion with full recovery at 1 year, with no differences in the frequency of complications between the two groups.
authors.affiliation: Service de Neurologie, Département de Pédiatrie, Cliniques Universitaires Saint-Luc, Université Catholique de Louvain, Avenue Hippocrate 10, 1200 Bruxelles, Belgium. pierre.defresne@freebel.net
authors.forename: P
authors.initials: P
authors.lastname: Defresne
authors.forename: L
authors.initials: L
authors.lastname: Meyer
authors.forename: M
authors.initials: M
authors.lastname: Tardieu
authors.forename: E
authors.initials: E
authors.lastname: Scalais
authors.forename: C
authors.initials: C
authors.lastname: Nuttin
authors.forename: B
authors.initials: B
authors.lastname: De Bont
authors.forename: G
authors.initials: G
authors.lastname: Loftus
authors.forename: P
authors.initials: P
authors.lastname: Landrieu
authors.forename: H
authors.initials: H
authors.lastname: Kadhim
authors.forename: G
authors.initials: G
authors.lastname: Sébire
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000009:adverse effects; D009188:Myelitis, Transverse / Q000188:drug therapy*
chemical_list: D008775:Methylprednisolone