[First experience with clinical use of intravenous anesthetic recofol: effectiveness and safety].
Clinical trials of a new anesthetic Recofol were carried out. This analog of well-known drug diprivan is characterized by a predominantly hypnotic effect. The effect of recofol on hemodynamics, gas exchange, and EEG was studied in 30 clinical trials during anesthesia for bronchoscopic manipulations and operations on the abdominal and thoracic organs, microsurgery, and during peripheral vessel repair. The results indicate that recofol is virtually identical to diprivan (propofol). Clinical course of induction and anesthesia, hemodynamic reactions and effect on the respiratory system of patients were virtually the same. Recofol was well tolerated, its allergenic activity was relatively low, it was rapidly metabolized, there were virtually no side effects. Positive results of recofol trials carried out by Leiras Oy firm recommend the drug for wide use in anesthesiology.
Buniatian
A A
AA
Vabishevich
A V
AV
Flerov
E V
EV
Stamov
V I
VI
Iumatov
A E
AE
Kochneva
Z V
ZV
D000328:Adult; D000367:Age Factors; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D004341:Drug Evaluation; D004569:Electroencephalography; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007546:Isoquinolines / Q000008:administration & dosage / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D000077590:Mivacurium; D003473:Neuromuscular Nondepolarizing Agents / Q000008:administration & dosage / Q000494:pharmacology; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*
D018686:Anesthetics, Intravenous; D007546:Isoquinolines; D003473:Neuromuscular Nondepolarizing Agents; D000077590:Mivacurium; D005283:Fentanyl; D015742:Propofol