1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-beta-D-glucose, a new hepatoprotective constituent from Combretum quadrangulare.
A new gallic acid derivative, 1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoyl-beta-D-glucose (1) has been isolated from an H2O-fraction of MeOH extract of Combretum quadrangulare seeds. Compound 1 exhibited potent hepatoprotective activity against D-GalN/TNF-alpha-induced cell death in primary cultured mouse hepatocytes with an IC50 of 3.3 microM.
Adnyana
I K
IK
Tezuka
Y
Y
Awale
S
S
Banskota
A H
AH
Tran
K Q
KQ
Kadota
S
S
D000818:Animals; D017209:Apoptosis / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005688:Galactosamine / Q000378:metabolism; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D022781:Hepatocytes / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008107:Liver Diseases / Q000517:prevention & control*; D051379:Mice; D015394:Molecular Structure; D010936:Plant Extracts / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
C431484:1-O-galloyl-6-O-(4-hydroxy-3,5-dimethoxy)benzoylglucose; D006027:Glycosides; D010936:Plant Extracts; D014409:Tumor Necrosis Factor-alpha; D005688:Galactosamine