Pemphigus foliaceus with prominent neutrophilic pustules.
We describe four patients with generalized scaly and pustular skin lesions showing extensive neutrophilic infiltration in the subcorneal region of the epidermis. Immunofluorescence, immunoblot and enzyme-linked immunosorbent assay analyses detected IgG antibodies reacting exclusively with desmoglein 1, the pemphigus foliaceus antigen. This study indicates that pemphigus foliaceus may show prominent neutrophilic pustular skin lesions.
Matsuo
K
K
Department of Dermatology, Kurume University School of Medicine, 67 Asahimachi, Kurume, Fukuoka 830-0011, Japan.
Komai
A
A
Ishii
K
K
Futei
Y
Y
Amagai
M
M
Deguchi
H
H
Danno
K
K
Hashimoto
T
T
D000328:Adult; D000368:Aged; D001324:Autoantigens / Q000276:immunology; D015820:Cadherins / Q000276:immunology; D051183:Desmoglein 1; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D020556:Neutrophil Infiltration; D010392:Pemphigus / Q000276:immunology / Q000473:pathology*; D012872:Skin Diseases, Vesiculobullous / Q000276:immunology / Q000473:pathology*
D001324:Autoantigens; D015820:Cadherins; D051183:Desmoglein 1; D007070:Immunoglobulin A; D007074:Immunoglobulin G