title: Prostatic adenocarcinoma with marked neuroendocrine differentiation.
abstract: A case is presented of prostatic cancer with marked neuroendocrine differentiation. Double-labeled immunohistochemical staining was performed with prostate-specific antigen and Chromogranin A. Both antibodies were localized to some of the cancer cells with Paneth cell-like features. Furthermore, most of the cancer cells were positively stained with luminal cell marker CAM 5.2, suggesting that neuroendocrine cells originated from the prostatic luminal cells.
authors.affiliation: Department of Urology, Shinshu University School of Medicine, Matsumoto, Japan. islam@hosp.md.shinshu-u.ac.jp
authors.forename: A M
authors.initials: AM
authors.lastname: Islam
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: M
authors.initials: M
authors.lastname: Hayama
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Ota
authors.forename: O
authors.initials: O
authors.lastname: Nishizawa
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology*; D002454:Cell Differentiation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009490:Neurosecretory Systems / Q000473:pathology*; D011471:Prostatic Neoplasms / Q000473:pathology*