New approach to multiply deuterated isoprenoids using triply engineered Escherichia coli and its potential as a tool for mechanistic enzymology.
Kakinuma
K
K
Department of Chemistry, Tokyo Institute of Technology, O-okayama, Meguro-ku, Tokyo 152-8551, Japan. kakinuma@chem.titech.ac.jp
Dekishima
Y
Y
Matsushima
Y
Y
Eguchi
T
T
Misawa
N
N
Takagi
M
M
Kuzuyama
T
T
Seto
H
H
D003903:Deuterium; D004798:Enzymes / Q000378:metabolism*; D004926:Escherichia coli / Q000737:chemistry* / Q000201:enzymology / Q000235:genetics; D045782:Hemiterpenes; D009943:Organophosphorus Compounds / Q000737:chemistry*
D004798:Enzymes; D045782:Hemiterpenes; D009943:Organophosphorus Compounds; C004809:isopentenyl pyrophosphate; D003903:Deuterium