Stem cells: so what's in a niche?
Much effort is being invested in defining the intrinsic and extrinsic factors that control stem cell maintenance and proliferation. Recent studies have identified a signaling hierarchy involved in coordinating the proliferation of germ line and somatic stem cells in the Drosophila ovary.
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Department of Developmental Biology, Stanford University Medical School, Beckman Center B-373, 279 Campus Drive, Stanford, California 94305, USA. dljones@cmgm.stanford.edu
D000818:Animals; D060565:Argonaute Proteins; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000166:cytology / Q000196:embryology*; D005260:Female; D005854:Germ Cells / Q000166:cytology; D053823:Hedgehog Proteins; D006801:Humans; D019476:Insect Proteins / Q000235:genetics / Q000378:metabolism; D010053:Ovary / Q000166:cytology / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000378:metabolism; D034743:RNA-Induced Silencing Complex; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology*; D013234:Stem Cells / Q000502:physiology*
D060565:Argonaute Proteins; D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D019476:Insect Proteins; D011506:Proteins; D034743:RNA-Induced Silencing Complex; C116498:piwi protein, Drosophila; C077245:hh protein, Drosophila