Oligodendroglial ganglioglioma with anaplastic features arising from the thalamus.
Anaplastic gangliogliomas with an oligodendroglial component are exceedingly rare tumors of uncertain growth potential. We report a 17-year-old female with a massive ganglioglioma containing anaplastic oligodendroglioma apparently arising from the thalamus. Two weeks after partial resection, she was started on a regimen including escalated doses of topotecan in combination with a fixed-dosage intensification regimen of cisplatin, cyclophosphamide and vincristine with subsequent hyperfractionated external beam radiotherapy. She currently has stable disease.
Johnson
M D
MD
Department of Pathology, Vanderbilt Medical School and Nashville Veteran's Administration Medical Center, Nashville, TN 37212, USA. Mahlon.Johnson@mcmail.vanderbilt.edu
Jennings
M T
MT
Toms
S T
ST
D000293:Adolescent; D001932:Brain Neoplasms / Q000473:pathology* / Q000601:surgery; D005260:Female; D018303:Ganglioglioma / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008279:Magnetic Resonance Imaging; D009837:Oligodendroglioma / Q000473:pathology* / Q000601:surgery; D013788:Thalamus / Q000473:pathology*