Role of coenzyme Q10 in chronic heart failure, angina, and hypertension.
OBJECTIVE
Coenzyme Q10 (CoQ10) has a pathophysiologic role in many disease states. The purpose of this review is to provide recommendations regarding the safety, efficacy, and dosing of CoQ10 in the management of chronic heart failure (CHF), angina, and hypertension.


METHODS
Literature pertaining to the safety and efficacy of CoQ10 specifically in cardiovascular indications was reviewed. We used relevant clinical trials, articles, reviews, and letters that were selected from a literature search of the MEDLINE database (1974-2000), Micromedex Healthcare Series, and the Natural Medicines Comprehensive Database.


RESULTS
Coenzyme Q10 administered orally has favorable actions in the described cardiovascular conditions and appears to be safe and well tolerated in the adult population. Issues concerning optimum target dosages, potential interactions, monitoring parameters, and the role of CoQ10 as a monotherapeutic agent need to be investigated further. Favorable effects of CoQ10 on ejection fraction, exercise tolerance, cardiac output, and stroke volume are demonstrated in the literature; thus, the use of CoQ10 as adjuvant therapy in patients with CHF may be supported.


CONCLUSIONS
Coenzyme Q10 therapy in angina and hypertension cannot be substantiated until additional clinical trials demonstrate consistent beneficial effects. However, CoQ10 may be recommended as adjuvant therapy in selected patients with CHE At this time, CoQ10 should not be recommended as monotherapy or first-line therapy in any disease state.
Tran
M T
MT
School of Pharmacy, Medical College of Virginia, Virginia Commonwealth University, Richmond, USA.
Mitchell
T M
TM
Kennedy
D T
DT
Giles
J T
JT
D000789:Angina, Unstable / Q000188:drug therapy* / Q000201:enzymology; D000818:Animals; D000975:Antioxidants / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic / Q000706:statistics & numerical data; D003067:Coenzymes; D006333:Heart Failure / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000201:enzymology; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics / Q000502:physiology* / Q000627:therapeutic use*
D000975:Antioxidants; D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10