Duffy antigen/receptor for chemokines (DARC): genotypes in Ashkenazi and non-Ashkenazi Jews in Israel.
Duffy genotypes were studied in Ashkenazi and non-Ashkenazi groups in Israel. The prevalence of the genotypes for the known polymorphic FY*A, FY*B, and FY*B(GATA-) alleles was similar in the two groups. The recently described FY*B(G298A) and FY*B(C265T) alleles were also found to be polymorphic. FY*B(G298A) was significantly more prevalent in the non-Ashkenazi group than in the Ashkenazi group (in 20% and 10% of FY*B, respectively). FY*B(C265T), which markedly diminishes the expression of Fy(b) antigen, was found in 3.5% of FY*B alleles, but only together with FY*B(G298A), consistent with previous suggestions that FY*B(C265T) occurred in the FY*B(G298A) allele. No difference in Duffy genotype distribution was found between schizophrenic and control groups. Duffy antigens are receptors for chemokines and bind Plasmodium vivax. Study of Duffy genotypes in additional populations might help in elucidating the possible functional significance of Duffy allele polymorphism.
Parasol
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N
Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Israel.
Cohen
N
N
Zemishlany
Z
Z
Lerer
B
B
Kosower
N S
NS
D000953:Antigens, Protozoan; D002352:Carrier Proteins / Q000235:genetics*; D016022:Case-Control Studies; D004375:Duffy Blood-Group System; D005838:Genotype; D006801:Humans; D007557:Israel; D007585:Jews / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
C473745:ACKR1 protein, human; D000953:Antigens, Protozoan; D002352:Carrier Proteins; D004375:Duffy Blood-Group System; C066001:Duffy antigen binding protein, Plasmodium; D015800:Protozoan Proteins; D011956:Receptors, Cell Surface