Endocarditis caused by penicillin-resistant viridans streptococci: 2 cases and controversies in therapy.
Although penicillin-resistant viridans streptococci have been isolated from samples from the mouth, blood, and wounds in increasing numbers, viridans streptococci isolated from patients with endocarditis have remained sensitive to penicillin for the past 5 decades. We report the cases of 2 patients with penicillin-resistant viridans streptococcal endocarditis, review 6 other cases from the literature, and summarize 2 studies that used an animal model of penicillin-resistant viridans streptococcal endocarditis.
Levy
C S
CS
Infectious Disease and Microbiology Services, Washington Hospital Center, 110 Irving Street NW, Washington, DC 20010, USA. csl3@mhg.edu
Kogulan
P
P
Gill
V J
VJ
Croxton
M B
MB
Kane
J G
JG
Lucey
D R
DR
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D010403:Penicillin Resistance; D011817:Rabbits; D013290:Streptococcal Infections / Q000188:drug therapy / Q000382:microbiology*; D013291:Streptococcus / Q000145:classification / Q000187:drug effects* / Q000302:isolation & purification; D013298:Streptococcus sanguis / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification
D000900:Anti-Bacterial Agents