title: Fatal gastrointestinal infection with 'Flexispira rappini'-like organisms in a cat.
abstract: A 4-month-old male British Blue cat with catarrhal to haemorrhagic enteritis showed massive colonization of the stomach, small intestine and caecum with spiral-shaped bacilli. In the stomach, organisms were located in foveolae and gland lumina and within unaltered and degenerate epithelial cells. Inflammatory infiltration was moderate and T cell dominated. In the intestine, bacilli were found in the gut lumen, berween villi, in crypt lumina and within epithelial cells. Degeneration of crypt epithelial cells as well as crypt dilation and moderate to massive macrophage-dominated infiltration of the mucosa and submucosa were observed. Immunohistochemically, bacilli were positive with an antibody against Helicobacter. Ultrastructurally, the organisms strongly resembled 'Flexispira rappini', a spiral-shaped Helicobacter species known as a normal intestinal colonizer in dogs and mice.
authors.affiliation: Institut für Veterinär-Pathologie, Justus-Liebig-Universität Giessen, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Kipar
authors.forename: M
authors.initials: M
authors.lastname: Weber
authors.forename: S
authors.initials: S
authors.lastname: Menger
authors.forename: D
authors.initials: D
authors.lastname: Harmsen
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D000942:Antigens, Bacterial / Q000032:analysis; D002371:Cat Diseases / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D002415:Cats; D017809:Fatal Outcome; D005767:Gastrointestinal Diseases / Q000276:immunology / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D016998:Helicobacter / Q000276:immunology* / Q000302:isolation & purification / Q000648:ultrastructure; D016481:Helicobacter Infections / Q000276:immunology / Q000382:microbiology / Q000662:veterinary*; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial