Planar polarity: getting ready to ROCK.
Cells in the Drosophila wing are polarised to produce a single distally pointing trichome. Recent studies show that this requires the recruitment of the Dishevelled protein to the distal cell edge, and the correct levels of Rho-associated kinase activity.
Strutt
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Centre for Developmental Genetics, Department of Biomedical Science, University of Sheffield, Western Bank, S10 2TN, Sheffield, UK.
D048868:Adaptor Proteins, Signal Transducing; D000818:Animals; D019521:Body Patterning; D000072261:Dishevelled Proteins; D004330:Drosophila / Q000196:embryology* / Q000378:metabolism; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D019476:Insect Proteins / Q000502:physiology; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000378:metabolism; D008954:Models, Biological; D010750:Phosphoproteins / Q000378:metabolism; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D043562:Receptors, G-Protein-Coupled; D054460:rho-Associated Kinases
D048868:Adaptor Proteins, Signal Transducing; D000072261:Dishevelled Proteins; D029721:Drosophila Proteins; D051157:Frizzled Receptors; D019476:Insect Proteins; D047908:Intracellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D010750:Phosphoproteins; D043562:Receptors, G-Protein-Coupled; C000606588:dsh protein, Drosophila; C058784:fz protein, Drosophila; D017346:Protein Serine-Threonine Kinases; D054460:rho-Associated Kinases