Altered values of heart rate variability in patients with relapse of atrial fibrillation during the first week after electrical cardioversion: preliminary data.
BACKGROUND
It has not so far been elucidated whether the autonomic nervous system plays a role in the pathogenesis of atrial fibrillation relapse after electrical cardioversion.


METHODS
In 40 consecutive patients with atrial fibrillation (22 males, 18 females, mean age 60 +/- 2 years) submitted to successful electrical cardioversion (external in 26 and low-energy internal in 14) we evaluated the heart rate variability (24-hour Holter recording) immediately after restoration of sinus rhythm in order to assess the cardiac sympatho-vagal drive.


RESULTS
Patients with atrial fibrillation relapse within the first week of electrical cardioversion were characterized by a significantly higher low/high frequency ratio.


CONCLUSIONS
Despite the heterogeneity of the studied population (concerning both the therapy and etiology of atrial fibrillation), our data strongly suggest that the evaluation of the low/high frequency ratio by means of power spectral analysis immediately after electrical cardioversion is a useful tool for the identification of those patients who are prone to atrial fibrillation recurrence. Our conclusions are supported by the finding of high positive and negative predictive values for the low/high frequency ratio both in the 24-hour period and during daytime.
Michelucci
A
A
Department of Internal Medicine, University of Florence, Italy. michelucci@unifi.it
Lazzeri
C
C
Padeletti
L
L
Bagliani
G
G
Colella
A
A
Sabini
A
A
Zipoli
R
R
Costoli
A
A
Pieragnoli
P
P
Gensini
G F
GF
Franchi
F
F
D000368:Aged; D000638:Amiodarone / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000628:therapy*; D002940:Circadian Rhythm / Q000502:physiology; D004554:Electric Countershock; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011237:Predictive Value of Tests; D011405:Propafenone / Q000627:therapeutic use; D012008:Recurrence; D012680:Sensitivity and Specificity; D013997:Time Factors; D014665:Vasodilator Agents / Q000627:therapeutic use; D014700:Verapamil / Q000627:therapeutic use
D014665:Vasodilator Agents; D011405:Propafenone; D014700:Verapamil; D000638:Amiodarone