title: Anti-CagA antibodies in Helicobacter pylori-positive patients and blood donors from Nigeria.
abstract: The prevalence of antibodies to CagA protein was evaluated in 174 Helicobacter pylori-positive. subjects: 110 patients submitted to upper gastrointestinal endoscopy and 64 male blood donors. The patients were from different regions of Nigeria: Jos, North, Benue,West and East and the blood donors were from Jos. Sera were assayed for anti-CagA antibodies using Helicobacter p120, CagA ELISA (Viva Diagnostika, Hürth, Germany). Anti-CagA antibodies were detected in 104 (94.5%) patients and in 61 (95.3%) blood donors (P=1.0). Patients from the Benue region presented a lower frequency of anti-CagA antibodies than patients from the other regions (P=0.0004). When the subjects were stratified by age, a significant increase in IgG concentration was observed among the men (P=0.03) but not among the women (P=0.57) or among the blood donors (P=0.83). In conclusion, similarly toAsian countries, CagA-positive H. pylori infection is highly frequent in Nigeria.
authors.affiliation: Laboratory of Research in Bacteriology, Faculdade de Medicina, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil.
authors.forename: A M
authors.initials: AM
authors.lastname: Rocha
authors.forename: G A
authors.initials: GA
authors.lastname: Rocha
authors.forename: D M
authors.initials: DM
authors.lastname: de Magalhães Queiroz
authors.forename: A E
authors.initials: AE
authors.lastname: Ani
authors.forename: E N
authors.initials: EN
authors.lastname: Okeke
authors.forename: C S
authors.initials: CS
authors.lastname: Bello
authors.forename: A O
authors.initials: AO
authors.lastname: Malu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000942:Antigens, Bacterial / Q000302:isolation & purification*; D001426:Bacterial Proteins / Q000302:isolation & purification*; D001782:Blood Donors / Q000706:statistics & numerical data; D016022:Case-Control Studies; D004381:Duodenal Ulcer / Q000382:microbiology; D016099:Endoscopy, Gastrointestinal / Q000706:statistics & numerical data; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016481:Helicobacter Infections / Q000453:epidemiology*; D016480:Helicobacter pylori / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D009549:Nigeria / Q000453:epidemiology; D015995:Prevalence
chemical_list: D000942:Antigens, Bacterial; D001426:Bacterial Proteins; C080866:cagA protein, Helicobacter pylori