Association between apolipoprotein B promotor haplotypes and cholesterol status.
Association between apolipoprotein B (apo B) promoter haplotypes and cholesterol concentration was studied in two groups of children with low and high concentrations of cholesterol. Strong linkage equilibrium was demonstrated between I/D in the signal peptide of apo B and (C-516T) polymorphism in the promotor of apo B gene, and the I/I+ allele T haplotype was associated with a low cholesterol concentration.
Hubacek
J A
JA
Laboratory of Atherosclerosis Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jaroslav.hubacek@medicon.cz
Pistulková
H
H
Skodová
Z
Z
Berg
K
K
Poledne
R
R
D001055:Apolipoproteins B / Q000235:genetics*; D002648:Child; D002784:Cholesterol / Q000097:blood*; D004247:DNA / Q000097:blood; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D021382:Protein Sorting Signals
D001055:Apolipoproteins B; D021382:Protein Sorting Signals; D004247:DNA; D002784:Cholesterol