title: Platelets in suspension require preactivation to adhere to immobilized fibrinogen.
abstract: Previous studies using whole blood perfusion through flow chambers have suggested that unactivated platelets can adhere to surface immobilized fibrinogen (Fg). However, the red blood cells needed for surface delivery of the platelets may activate platelets by released adenosine diphosphate (ADP). Our studies of coaggregation of unactivated or ADP-activated platelets with Fg-coated latex beads in flowing suspensions show that only preactivated platelets can adhere to Fg-coated surfaces.
authors.affiliation: Unité 353 INSERM, Institut d'Hématologie, Hôpital St Louis, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Bonnefoy
authors.forename: Q
authors.initials: Q
authors.lastname: Liu
authors.forename: W G
authors.initials: WG
authors.lastname: Jerome
authors.forename: C
authors.initials: C
authors.lastname: Legrand
authors.forename: M M
authors.initials: MM
authors.lastname: Frojmovic
mesh_terms: D001792:Blood Platelets / Q000166:cytology* / Q000378:metabolism; D002448:Cell Adhesion; D005340:Fibrinogen / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D015539:Platelet Activation
chemical_list: D005340:Fibrinogen