title: Mannan-binding lectin enhances susceptibility to visceral leishmaniasis.
abstract: Levels of the serum opsonin mannan-binding lectin (MBL) were directly correlated with the probability of developing visceral leishmaniasis. Monocytes infected with MBL-opsonized Leishmania chagasi promastigotes secreted higher levels of tumor necrosis factor alpha and interleukin-6 than cells infected with nonopsonized parasites. Our findings indicate that MBL can modulate the clinical outcome of infection with L. chagasi and the function of infected macrophages.
authors.affiliation: Department of Immunology and Infectious Diseases, Harvard School of Public Health, Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: I K
authors.initials: IK
authors.lastname: Santos
authors.forename: C H
authors.initials: CH
authors.lastname: Costa
authors.forename: H
authors.initials: H
authors.lastname: Krieger
authors.forename: M F
authors.initials: MF
authors.lastname: Feitosa
authors.forename: D
authors.initials: D
authors.lastname: Zurakowski
authors.forename: B
authors.initials: B
authors.lastname: Fardin
authors.forename: R B
authors.initials: RB
authors.lastname: Gomes
authors.forename: D L
authors.initials: DL
authors.lastname: Weiner
authors.forename: D A
authors.initials: DA
authors.lastname: Harn
authors.forename: R A
authors.initials: RA
authors.lastname: Ezekowitz
authors.forename: J E
authors.initials: JE
authors.lastname: Epstein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002352:Carrier Proteins / Q000097:blood / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D037222:Collectins; D004198:Disease Susceptibility; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000378:metabolism; D037102:Lectins / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D018314:Leishmania infantum / Q000235:genetics / Q000276:immunology* / Q000302:isolation & purification; D007898:Leishmaniasis, Visceral / Q000097:blood / Q000276:immunology* / Q000469:parasitology; D008351:Mannans; D008875:Middle Aged; D009895:Opsonin Proteins / Q000235:genetics / Q000276:immunology* / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D037222:Collectins; D015850:Interleukin-6; D037102:Lectins; D008351:Mannans; D009895:Opsonin Proteins; D014409:Tumor Necrosis Factor-alpha