[Effect of glutamate on spontaneous secretion of acetylcholine in the nerve-muscle synapse in rats].
In rats, glutamate was shown to exert no effect on the mean frequency, character of interstimuli distribution, amplitude and temporal parameters of the miniature EPPs. Glutamate suppressed nonquantal release. The glutamate effect depended on its concentration and was abolished by blockade of NMDA receptors, NO-synthase inhibitoin, and NO molecules binding by haemoglobin in extracellular medium. Glutamate seems to modulate the nonquantal acetylcholine secretion by initiation of the NO synthesis in muscle fibres via activation of the NMDA receptors.
Malomuzh
A I
AI
Kazan Institute of Biochemistry and Biophysics of the Russian Acad. Sci., Russia, 420503, Kazan, Box 30.
Mukhtarov
M R
MR
Urazaev
A Kh
AKh
Nikol'skiĭ
E E
EE
Vyskocil
F
F
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D003964:Diaphragm / Q000502:physiology / Q000648:ultrastructure; D004791:Enzyme Inhibitors / Q000494:pharmacology; D018698:Glutamic Acid / Q000494:pharmacology / Q000502:physiology*; D006418:Heme / Q000378:metabolism; D066298:In Vitro Techniques; D009045:Motor Endplate / Q000502:physiology; D009469:Neuromuscular Junction / Q000187:drug effects / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D051381:Rats
D004791:Enzyme Inhibitors; D009569:Nitric Oxide; D018698:Glutamic Acid; D006418:Heme; D019001:Nitric Oxide Synthase; D000109:Acetylcholine