[Influential factors in the elevation of serum creatine phosphokinase for the patients with Kanemi Yusho--freeze fracture study of rat muscle plasma membrane].
We studied the factors of the elevation of serum creatine phosphokinase (CK) using the data from the routine medical checkup of Kanemi Yusho patients during 1995 and 1999. We also studied rat muscle plasma membrane by the freeze fracture method, which were given the polychlorinated biphenyls (PCB) and controls. The patients with elevation of serum CK showed significant elevation of PCB in their blood but not in polychlorinated quanterphenyls (PCQ). The rat muscle plasma membrane showed a slight increase of orthognal array density but it was not statistically significant. The densities of caveolae and particles were not changed. Accordingly, PCB were thought to be a factor in the elevation of CK in the serum.
Yoshimura
T
T
School of Allied Medical Sciences, Nagasaki University, Nagasaki 852-8520.
Okita
M
M
Nakao
Y
Y
Fukuda
T
T
Fujimoto
T
T
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002722:Chlorobenzenes / Q000097:blood; D003402:Creatine Kinase / Q000097:blood*; D005506:Food Contamination; D005614:Freeze Fracturing; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000166:cytology / Q000378:metabolism*; D012275:Oryza / Q000506:poisoning*; D010938:Plant Oils / Q000506:poisoning*; D011078:Polychlorinated Biphenyls / Q000506:poisoning*; D051381:Rats; D017207:Rats, Sprague-Dawley
D002722:Chlorobenzenes; D010938:Plant Oils; C022053:polychlorinated quaterphenyls; D011078:Polychlorinated Biphenyls; D003402:Creatine Kinase