title: The perinatal thyroid in iodine deficient regions: risks of radioiodines--hazards of stable iodine overload. A study in the newborn rat.
abstract: Administration of large quantities of stable iodine is an effective means of reducing the radiation burden on the thyroid in the event of a nuclear power-plant accident. Such administration may involve countries with low baseline dietary iodine intake. It is questioned whether stable iodine overload is safe, and in particular, what are its effects in newborn infants? Iodine-deficient newborn rats were submitted to a single acute administration of stable iodine (100 microg) on the second day of life. The effects on thyroid structure were studied, after 24 hr and after 7 days, using light microscopy. Compared to controls, the thyroids of animals submitted to stable iodine overload showed, 7 days after treatment, signs of acute toxicity including marked desquamation of epithelial cells and rupture of a large number of thyroid follicles. Our findings in iodine deficient newborn rats suggest that stable iodine overload may have side effects during perinatal life. This prophylactic measure should, therefore, be accompanied by follow-up of thyroid function. Thyroid hormones are critical for brain development, during the first period of life.
authors.affiliation: Service de Médecine Nucléaire, Hĵpital Saint-Antoine, Assistance Publique des Hĵpitaux de Paris, France. elif.hindie@sat.ap-hop-paris.fr
authors.forename: E
authors.initials: E
authors.lastname: Hindié
authors.forename: F
authors.initials: F
authors.lastname: Walker
authors.forename: A
authors.initials: A
authors.lastname: Petiet
authors.forename: K
authors.initials: K
authors.lastname: Bourahla
authors.forename: P
authors.initials: P
authors.lastname: Galle
authors.forename: N
authors.initials: N
authors.lastname: Colas-Linhart
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004032:Diet; D007455:Iodine / Q000008:administration & dosage / Q000009:adverse effects* / Q000172:deficiency* / Q000627:therapeutic use; D008853:Microscopy; D011832:Radiation Injuries / Q000378:metabolism / Q000517:prevention & control; D018788:Radioactive Hazard Release; D051381:Rats; D017208:Rats, Wistar; D013959:Thyroid Diseases / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control; D013961:Thyroid Gland / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology*
chemical_list: D007455:Iodine