Effects of the aqueous and methylene chloride extracts of Bidens pilosa leaf on fructose-hypertensive rats.
We investigated the effects of the aqueous (150-350 mg/kg) and methylene chloride (150-300 mg/kg) extracts of Bidens pilosa on fructose-induced hypertension in rats. Food and liquid intake were measured as well as systolic blood pressure and plasma levels of glucose, insulin, cholesterol, triglycerides and creatinine. Fructose feeding for 6 weeks induced hypertension, hyperinsulinemia and increased plasma triglyceride levels in male Wistar rats. The aqueous and methylene chloride extracts of B. pilosa reversed the high blood pressure and hypertriglyceridemia developed due to fructose feeding but did not have any effects on plasma levels of insulin and glucose. High doses of the extracts reduced plasma creatinine levels and tended to increase plasma cholesterol. These results suggest that the extracts of B. pilosa possess hypotensive effects whose mechanism of action is not related to insulin sensitivity.
Dimo
T
T
Department of Animal Biology and Physiology, Faculty of Sciences, University of Yaounde I, PO Box 812, Yaounde, Cameroon.
Azay
J
J
Tan
P V
PV
Pellecuer
J
J
Cros
G
G
Bopelet
M
M
Serrano
J J
JJ
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D019659:Asteraceae / Q000737:chemistry*; D001794:Blood Pressure / Q000187:drug effects*; D019422:Dietary Sucrose / Q000009:adverse effects*; D005632:Fructose / Q000009:adverse effects*; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D016488:Medicine, African Traditional; D008752:Methylene Chloride / Q000494:pharmacology; D008517:Phytotherapy; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D014867:Water
D000959:Antihypertensive Agents; D019422:Dietary Sucrose; D010936:Plant Extracts; D014867:Water; D005632:Fructose; D008752:Methylene Chloride