Absence of human herpesvirus-6 genome by polymerase chain reaction in children with Hodgkin disease: a Children's Cancer Group Lymphoma Biology Study.
BACKGROUND
Human herpesvirus-6 (HHV6) has been implicated in adult lymphomas but the role that HHV6 has in lymphomagenesis is unclear. Because primary infection occurs in children, a prospective study was undertaken to detect HHV6 in those with pediatric Hodgkin disease (HD).


METHODS
Tumor was obtained from children with HD entered on a Children's Cancer Group Biology Study. Polymerase chain reaction (PCR) was performed using HHV6 primers. All 47 specimens (40 nodular sclerosing; 3 lymphocyte predominant; 3 mixed cellularity; and 1 unclassified) were negative for HHV6.


CONCLUSIONS
The results demonstrate no HHV6 sequence in childhood HD.
Shiramizu
B
B
University of Hawaii, Honolulu, USA. bshirami@hawaii.edu
Chang
C W
CW
Cairo
M S
MS
D002648:Child; D004273:DNA, Neoplasm / Q000032:analysis; D004279:DNA, Viral / Q000302:isolation & purification*; D015654:Herpesvirus 6, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000473:pathology / Q000821:virology*; D006801:Humans; D016133:Polymerase Chain Reaction; D012680:Sensitivity and Specificity
D004273:DNA, Neoplasm; D004279:DNA, Viral