title: Conformational restriction of flexible ligands guided by the transferred noe experiment: potent macrocyclic inhibitors of farnesyltransferase.
authors.forename: C J
authors.initials: CJ
authors.lastname: Dinsmore
authors.forename: M J
authors.initials: MJ
authors.lastname: Bogusky
authors.forename: J C
authors.initials: JC
authors.lastname: Culberson
authors.forename: J M
authors.initials: JM
authors.lastname: Bergman
authors.forename: C F
authors.initials: CF
authors.lastname: Homnick
authors.forename: C B
authors.initials: CB
authors.lastname: Zartman
authors.forename: S D
authors.initials: SD
authors.lastname: Mosser
authors.forename: M D
authors.initials: MD
authors.lastname: Schaber
authors.forename: R G
authors.initials: RG
authors.lastname: Robinson
authors.forename: K S
authors.initials: KS
authors.lastname: Koblan
authors.forename: H E
authors.initials: HE
authors.lastname: Huber
authors.forename: S L
authors.initials: SL
authors.lastname: Graham
authors.forename: G D
authors.initials: GD
authors.lastname: Hartman
authors.forename: J R
authors.initials: JR
authors.lastname: Huff
authors.forename: T M
authors.initials: TM
authors.lastname: Williams
mesh_terms: D019883:Alkyl and Aryl Transferases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D004791:Enzyme Inhibitors / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology*; D051231:Farnesyltranstransferase; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D004791:Enzyme Inhibitors; D019883:Alkyl and Aryl Transferases; C083291:geranylgeranyltransferase type-I; D051231:Farnesyltranstransferase