Immunity to Bordetella pertussis.
Bordetella pertussis exploits extracellular and intracellular niches in the respiratory tract and a variety of immune evasion strategies to prolong its survival in the host. This article reviews evidence of complementary roles for cellular and humoral immunity in protection. It discusses the effector mechanisms of bacterial elimination, the strategies employed by the bacteria to subvert protective immune responses and the immunological basis for systemic and neurological responses to infection and vaccination.
Mills
K H
KH
Infection and Immunity Group, Institute of Immunology, Department of Biology, National University of Ireland, Maynooth, Co., Kildare, Ireland. kingston.mills@may.ie
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood*; D001886:Bordetella pertussis / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D051379:Mice; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D014917:Whooping Cough / Q000276:immunology* / Q000517:prevention & control
D000907:Antibodies, Bacterial; D010567:Pertussis Vaccine