Neuropharmacological profile of ethnomedicinal plants of Guatemala.
We carried out the Irwin's test with some different extracts of the aerial parts of Thidax procumbens L., the leaves of Neurolaena lobata (L.) R. Br., bark and leaves of Byrsonima crassifolia (L.) Kunth. and Gliricidia sepium Jacq. Walp., and root and leaves of Petiveria alliacea L. At dosage of 1.25 g dried plant/kg weight aqueous extracts of bark and leaves of Byrsonima crassifolia (L.) Kunth. and Gliricidia sepium Jacq. Walp. demonstrated the most activity: decrease in motor activity, back tonus, reversible parpebral ptosis, catalepsy and strong hypothermia. These extracts of both plants were assayed for effects on CNS and they caused very significant reductions in spontaneous locomotor activity, exploratory behavior and rectal temperature and they increased the sodium pentobarbital-induced sleeping time.
Morales Cifuentes
C
C
Departamento de Farmacología, Facultad de Farmacia, Universidad Complutense de Madrid, 28040 Madrid, Spain.
Gómez-Serranillos
M P
MP
Iglesias
I
I
Villar del Fresno
A M
AM
Morales
C
C
Paredes
M E
ME
Cáceres
A
A
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D019448:Ethnobotany; D005260:Female; D006166:Guatemala; D006990:Hypnosis / Q000379:methods; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000008:administration & dosage; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves; D018547:Plant Stems; D010946:Plants, Medicinal
D010936:Plant Extracts; D010424:Pentobarbital