title: [Contrast enhanced MR-angiography (CE-MRA): do contrast media with higher T1 relaxation improve imaging of carotid stenoses?].
abstract: OBJECTIVE
  CE-MRA is a powerful tool for the non-invasive evaluation of carotid artery occlusive disease. However, due to certain drawbacks, it has not completely replaced DSA. The purpose of this study was to evaluate if Gd-BOPTA, a contrast agent with high T1 relaxivity, can increase the diagnostic accuracy of CE-MRA.
  
  
  METHODS
  The CE-MRA examinations of 54 consecutive patients were evaluated by two experienced radiologists, independently. The examinations of 27 patients were contrasted either with 20 ml Gd-BOPTA or with 20 ml Gd-DTPA. The reviewers were blinded to the contrast agent chosen and to the ultrasound results. They rated the overall image quality and the degree of the ICA stenoses.
  
  
  RESULTS
  For the estimation of the degree of the ICA stenoses there was a high interrater validity. In comparison to the ultrasound findings, 6 of 50 high-degree stenoses were underestimated as moderate stenoses. In one of seven sonographically occluded vessels, MRA revealed residual patency in the vessel lumen. It was not possible to identify the contrast agent that was taken for a study. Subjective estimation of the image quality (arterial contrast of the ICA, contrast of the other vessels, and general impression) did not significantly change with the contrast agent employed.
  
  
  CONCLUSIONS
  The diagnostic accuracy of CE-MRA for the evaluation of internal carotid artery stenoses is not improved by Gd-BOPTA if identical volumina of contrast media are applied. The potential of this contrast agent can be the reduction of the amount of contrast without loss of diagnostic information. Further studies are necessary.
authors.affiliation: Abteilung für Neuroradiologie, Radiologischen Klinik, Eberhard-Karls-Universität Tübingen. sdfriese@med.uni-tuebingen.de
authors.forename: S
authors.initials: S
authors.lastname: Friese
authors.forename: H
authors.initials: H
authors.lastname: Krapf
authors.forename: M
authors.initials: M
authors.lastname: Fetter
authors.forename: R
authors.initials: R
authors.lastname: Vonthein
authors.forename: M
authors.initials: M
authors.lastname: Skalej
authors.forename: W
authors.initials: W
authors.lastname: Küker
mesh_terms: D000368:Aged; D002343:Carotid Artery, Internal / Q000473:pathology; D016893:Carotid Stenosis / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008536:Meglumine / Q000031:analogs & derivatives; D008875:Middle Aged; D015588:Observer Variation; D009942:Organometallic Compounds; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C064572:gadobenic acid; D008536:Meglumine