title: New hemisynthetic manoyl oxide derivatives with antimicrobial activity.
abstract: The synthesis and antimicrobial activity of ten labdane-type diterpenes derived from ent-3-beta-hydroxy-13-epi-manoyl oxide (ribenol) is reported. The chloroethyl carbamidic ester 9 showed the strongest antimicrobial activity against all the tested gram (+), gram (-) bacteria and pathogenic fungi. Moreover, the glycoside 11 exhibited an interesting activity against the three tested fungi.
authors.affiliation: Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, Greece.
authors.forename: E
authors.initials: E
authors.lastname: Kalpoutzakis
authors.forename: N
authors.initials: N
authors.lastname: Aligiannis
authors.forename: S
authors.initials: S
authors.lastname: Mitaku
authors.forename: L
authors.initials: L
authors.lastname: Chinou
authors.forename: C
authors.initials: C
authors.lastname: Charvala
authors.forename: A L
authors.initials: AL
authors.lastname: Skaltsounis
mesh_terms: D000812:Anhydrides; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013729:Terpenes / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000812:Anhydrides; D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D013729:Terpenes