title: [Incidence of high grade prostatic intraepithelial neoplasm in transrectal biopsy of the prostate].
abstract: OBJECTIVE
  To analyze the incidence of high grade prostatic intraepithelial neoplasia (PIN) in the transrectal prostate biopsies of patients from the Urology department.
  
  
  METHODS
  From 1995 to 1999, 2018 patients aged 46-92 years (mean 68 +/- 10) had a transrectal biopsy. Thirty-six percent had a suspicious DRE and the mean serum PSA was 31.7 +/- 152.9 ng/ml. The anatomopathological diagnoses were: a) cancer, b) benign pathology, c) high grade PIN and d) glandular atypia. Statistical analysis using the chi square and Mann-Whitney tests was performed to compare the following variables: age, DRE, PSA, PSAf/PSAt ratio and the finding of a suspicious node on ultrasound.
  
  
  RESULTS
  The incidence of high grade PIN in this series was 8% and the incidence of prostate cancer was 38.6%, PIN grade 3 was diagnosed in 94 patients and PIN grade 2 in 67, and was associated with glandular atypia in 13 patients. Patients with prostate cancer were older and showed statistically significant higher PSA, percentage of suspicious DRE, sonographically suspicious nodes, and a lower PSAf/PSAt ratio than the other diagnoses (p < 0.001). Comparison of patients with high grade PIN and those with benign pathology showed no differences for age, DRE, PSA levels and PSAf/PSAt ratio. However, a significantly lower incidence of sonographically suspicious nodes was found (p < 0.001).
  
  
  CONCLUSIONS
  The incidence of high grade PIN was 8%. High grade PIN does not cause sufficient changes in the clinical variables analyzed to suspect this lesion before it is confirmed by the pathological findings.
authors.affiliation: Servicios de Urología, Hospital General Universitario Gregorio Marañón, Madrid, España.
authors.forename: F
authors.initials: F
authors.lastname: Herranz Amo
authors.forename: E
authors.initials: E
authors.lastname: Alvarez Fernández
authors.forename: J M
authors.initials: JM
authors.lastname: Díez Cordero
authors.forename: F
authors.initials: F
authors.lastname: Verdú Tartajo
authors.forename: A
authors.initials: A
authors.lastname: Bielsa Carrillo
authors.forename: J
authors.initials: J
authors.lastname: García Burgos
authors.forename: D
authors.initials: D
authors.lastname: Subirá Ríos
authors.forename: I
authors.initials: I
authors.lastname: Castaño González
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D019048:Prostatic Intraepithelial Neoplasia / Q000453:epidemiology* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000453:epidemiology* / Q000473:pathology; D012189:Retrospective Studies