Biomechanics of cardiovascular development.
It long has been known that mechanical forces play a role in the development of the cardiovascular system, but only recently have biomechanical engineers begun to explore this field. This paper reviews some of this work. First, an overview of the relevant biology is discussed. Next, a mechanical theory is presented that can be used to model developmental processes. The theory includes the effects of finite volumetric growth and active contractile forces. Finally, applications of this and other theories to problems of cardiovascular development are discussed, and some future directions are suggested. The intent is to stimulate further interest among engineers in this important area of research.
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Department of Biomedical Engineering, Campus Box 1097, Washington University, St. Louis, Missouri 63130, USA. lat@biomed.wustl.edu
D000818:Animals; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering / Q000379:methods; D002320:Cardiovascular Physiological Phenomena; D006321:Heart / Q000196:embryology / Q000254:growth & development; D006801:Humans; D008955:Models, Cardiovascular