T cell death and memory.
In typical immune responses, contact with antigen causes naive T cells to proliferate and differentiate into effector cells. After the pathogen is destroyed, most effector T cells are eliminated-thereby preserving the primary T cell repertoire-but some cells survive and form long-lived memory cells. During each stage of this process, the life or death fate of T cells is strictly regulated.
Sprent
J
J
Department of Immunology, IMM4, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. jsprent@scripps.edu
Tough
D F
DF
D000818:Animals; D016923:Cell Death; D002470:Cell Survival; D016207:Cytokines / Q000502:physiology; D007156:Immunologic Memory; D007239:Infections / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines