[Study of relativity between HBV M and HBV DNA in the cases with hepatitis B].
OBJECTIVE
Serum samples of 414 cases with hepatitis B were detected for hepatitis B markers (HBV M) and HBV DNA, in order to investigation the relationship between HBV M and HBV DNA, and its clinical significant.


METHODS
HBV M and HBV DNA were detected by ELISA and blot hybridization methods respectively.


RESULTS
HBV DNA positive rates in the groups of acute and chronic hepatitis B were higher than that in the group of liver cirrhosis (P <0.01); HBV DNA positive rates had no apparent difference between the HBsAg, HBeAg, anti-HBc positive group and the HBsAg, anti-HBs, anti-HBc positive group. Direct relativity was shown between the titer of HBsAg and/or HBeAg and the positive rate of HBV DNA.


CONCLUSIONS
HBV DNA can be treated as a sign of HBV activity; the appearance of anti-HBs can not be taken as indicator of ceasing of HBV replication; the changes in HBsAg and HBeAg titers may be used as clinical evaluation on HBV replication and index for anti-viral therapeutic effect.
Meng
Q
Q
Beijing Youan Hospital, Beijing 100054, China.
Liang
R
R
Liu
D
D
D000328:Adult; D004279:DNA, Viral / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006510:Hepatitis B Antibodies / Q000097:blood*; D006512:Hepatitis B Core Antigens / Q000097:blood; D006514:Hepatitis B Surface Antigens / Q000097:blood; D006513:Hepatitis B e Antigens / Q000097:blood; D006515:Hepatitis B virus / Q000235:genetics / Q000276:immunology*; D019694:Hepatitis B, Chronic / Q000276:immunology / Q000821:virology*; D006801:Humans; D017403:In Situ Hybridization; D008297:Male; D014779:Virus Replication
D004279:DNA, Viral; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens