Cycle-regulated genes and cell cycle regulation.
The transcriptional profile of the entire Caulobacter crescentus genome over a synchronous cell cycle was recently described. The analysis reveals a stunning 553 cell-cycle-regulated genes or orfs, nearly 19% of the genome, including putative functions in virtually all biological activities. Over a quarter of these genes/orfs respond to the Caulobacter master regulator, CtrA, most of them apparently indirectly. The analysis confirms and extends earlier observations showing that many proteins involved in cell cycle functions are expressed at the cell age when they are needed. Conversely, the data suggest that proteins specifically expressed at a particular age may be involved in a process taking place then.
D'Ari
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Institut Jacques Monod (C.N.R.S., Universités Paris 6, Paris 7), 2 place Jussieu, F-75251 Paris Cedex 05, France. dari@ijm.jussieu.fr
D001426:Bacterial Proteins / Q000235:genetics* / Q000378:metabolism; D016935:Caulobacter crescentus / Q000235:genetics* / Q000378:metabolism; D002453:Cell Cycle / Q000502:physiology; D004268:DNA-Binding Proteins; D015964:Gene Expression Regulation, Bacterial; D018816:Genes, cdc; D016680:Genome, Bacterial; D014157:Transcription Factors
D001426:Bacterial Proteins; C097706:CtrA protein, Caulobacter; D004268:DNA-Binding Proteins; D014157:Transcription Factors