Prospective study of antibody to human papilloma virus type 16 and risk of cervical, endometrial, and ovarian cancers (United States).
OBJECTIVE
Human papilloma virus (HPV) is frequently detectable in cancers of the cervix, vagina, and vulva, but its role in endometrial and ovarian cancers is less certain. This analysis aimed to examine the association of presence of HPV type 16 (HPV-16) antibodies with subsequent risk of cervical, endometrial, and ovarian cancers.


METHODS
In a prospective study enrolling over 15,000 pregnant women, pre-cancer sera from women who developed cervical (n = 83), endometrial (n = 34), and ovarian (n = 35) cancers were compared with sera from 172 control women frequency-matched by age group and race.


RESULTS
HPV-16 seropositivity (OR = 2.0, 95% CI 1.0-3.4) was associated with cervical cancer, with the association more prominent for cancers occurring within 10 years of serum sampling (OR = 2.3, 95% CI 1.0-5.3) than cancers occurring later (OR = 1.6, 95% CI 0.75-3.6). Overall, the associations between HPV-16 seropositivity and endometrial (OR = 1.6, 95% CI 0.64-3.8) and ovarian cancers (OR = 1.1, 95% CI 0.43-2.8) were not significant, although the odds ratios for those cancers occurring within 20 years after serum sampling were similar to that for cervical cancer (OR = 2.2 for both).


CONCLUSIONS
Our results confirm that HPV-16 infection precedes the development of cervical cancer. Predictability of HPV-16 seropositivity for risk of other female cancers warrants further investigation.
Hisada
M
M
Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, USA.
van den Berg
B J
BJ
Strickler
H D
HD
Christianson
R E
RE
Wright
W E
WE
Waters
D J
DJ
Rabkin
C S
CS
D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002140:California / Q000453:epidemiology; D016009:Chi-Square Distribution; D004279:DNA, Viral / Q000302:isolation & purification; D016889:Endometrial Neoplasms / Q000453:epidemiology / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D005833:Genital Neoplasms, Female / Q000175:diagnosis / Q000453:epidemiology* / Q000821:virology*; D006801:Humans; D008875:Middle Aged; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000453:epidemiology / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D011247:Pregnancy; D015995:Prevalence; D011446:Prospective Studies; D012306:Risk; D014412:Tumor Virus Infections / Q000150:complications / Q000453:epidemiology* / Q000276:immunology; D002583:Uterine Cervical Neoplasms / Q000453:epidemiology / Q000821:virology
D000914:Antibodies, Viral; D004279:DNA, Viral