title: Scavenging of fluorinated N,N'-dialkylureas by hydrogen binding: a novel separation method for fluorous synthesis.
abstract: [reaction: see text] A dramatic solubility increase in fluorous solvents is observed for N,N'-di(polyfluoroalkyl)ureas when hydrogen binding complexes are formed with commercially available perfluoroalkanoic acid scavengers. As a case example, analytically pure peptides and esters are obtained using this novel separation method.
authors.affiliation: Departamento de Química Orgánica-I, Universidad del País Vasco, Facultad de Química, Apdo 1072, 20080 San Sebastián, Spain. qppaiipj@sc.ehu.es
authors.forename: C
authors.initials: C
authors.lastname: Palomo
authors.forename: J M
authors.initials: JM
authors.lastname: Aizpurua
authors.forename: I
authors.initials: I
authors.lastname: Loinaz
authors.forename: M J
authors.initials: MJ
authors.lastname: Fernandez-Berridi
authors.forename: L
authors.initials: L
authors.lastname: Irusta
mesh_terms: D004952:Esters / Q000302:isolation & purification; D005466:Fluorocarbons / Q000737:chemistry*; D010455:Peptides / Q000302:isolation & purification*; D014508:Urea / Q000031:analogs & derivatives*
chemical_list: D004952:Esters; D005466:Fluorocarbons; D010455:Peptides; D014508:Urea