Increased oxidative stress in childhood atopic dermatitis.
Atopic dermatitis (AD) is a chronic inflammatory skin disease of unknown etiology. To examine the involvement of impaired homeostasis of oxygen/nitrogen radicals in childhood AD, we compared the levels of urinary 8-hydroxy-2'-deoxyguanosine (marker of oxidative stress), nitrite/nitrate (marker of nitric oxide synthesis) and selenium (marker of selenium store) in 27 children with AD to those of 25 healthy control children. Urinary 8-hydroxy-2'-deoxyguanosine was significantly higher and nitrite/nitrate levels were significantly lower in patients with AD than in the control. Urinary selenium levels were similar in both groups. Our findings suggest that impaired homeostasis of oxygen/nitrogen radicals and increased oxidative stress are involved in the pathophysiology of childhood AD, and indicate that suppression of oxidative stress might be a potentially useful strategy for the treatment of AD.
Omata
N
N
Department of Pediatrics, Fukui Medical University, Japan.
Tsukahara
H
H
Ito
S
S
Ohshima
Y
Y
Yasutomi
M
M
Yamada
A
A
Jiang
M
M
Hiraoka
M
M
Nambu
M
M
Deguchi
Y
Y
Mayumi
M
M
D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine*; D003876:Dermatitis, Atopic / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D009566:Nitrates / Q000652:urine; D009573:Nitrites / Q000652:urine; D018384:Oxidative Stress; D012643:Selenium / Q000652:urine
D009566:Nitrates; D009573:Nitrites; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D012643:Selenium