[A preliminary study on the activation of superoxide dismutase by Tiopronin in patients with chronic hepatitis B].
OBJECTIVE
To observe the clearance effect of Tiopronin on oxygen free radicals in chronic hepatitis B patients.


METHODS
The ranthine oxidase assay was used to detect superoxide dismutase (SOD) in 80 chronic hepatitis B patients, the ALT, TBil, TP and AIG ratio of the patients were also tested. The 80 chronic hepatitis B patients were divided into two groups, the control group was treated with routine liver protective and jaundice regressing drugs while the treated group was additionally administered with Tiopromin besides the routine treatment.


RESULTS
In two groups of patients with similar ages and sexes, there showed no differences in levels of SOD, ALT, TBil, TP and ALB before treatment, as the SOD in treated group and control group were 106.57 (40.68 NU/ml and 105.18(44.59 NU/ml respectively, while the normal value for SOD in 16 normal persons was 165.9(23.36 NU/ml. After treatment, there were significant differences (P< 0.01) in SOD, ALT, TBil and ALB levels which showed SOD 187.93(35.24 NU/ml, ALT 38.41(22.22 U/L, TBil 23.15(12.46 micromol/L, ALB 43.28 (4.21 g/L in the treated group and SOD 157.96(47.29 NU/ml, ALT 68.52(34.19 U/L, TBil 30.38(21.80 micromol/L and ALB 40.36(5.19 g/L in the control group.


CONCLUSIONS
There showed a good therapeutic effect of Tiopronin on the clearance of oxygen free radicals in chronic hepatitis B patients and also it can improve the liver function.
Chen
C
C
The 3rd People's Hospital of Yichang City, Hubei, Yichang 443003, China.
Tan
Z
Z
Qiu
S
S
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D019694:Hepatitis B, Chronic / Q000188:drug therapy* / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013482:Superoxide Dismutase / Q000378:metabolism*; D008625:Tiopronin / Q000627:therapeutic use*; D016896:Treatment Outcome
D001798:Blood Proteins; D016166:Free Radical Scavengers; D008625:Tiopronin; D013482:Superoxide Dismutase; D000410:Alanine Transaminase; D001663:Bilirubin