Activation of caspase-3/caspase-3-like activity in rat cardiomyocytes by an RGD peptide, but not the GPIIb/IIIa antagonist lotrafiban.
Erhardt
J A
JA
Department of Cardiovascular Pharmacology, GlaxoSmithKline, King of Prussia, PA 19406, USA. joseph_a_erhardt@sbphrd.com
Ohlstein
E H
EH
Toomey
J R
JR
Gabriel
M A
MA
Willette
R N
RN
Yue
T L
TL
Barone
F C
FC
Parsons
A A
AA
D000818:Animals; D001569:Benzodiazepines; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism*; D002478:Cells, Cultured / Q000187:drug effects; D003374:Coumarins / Q000378:metabolism; D004789:Enzyme Activation; D005343:Fibrinolytic Agents / Q000494:pharmacology* / Q000633:toxicity; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000166:cytology / Q000201:enzymology*; D009842:Oligopeptides / Q000378:metabolism / Q000494:pharmacology*; D010880:Piperidines; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000633:toxicity; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000037:antagonists & inhibitors*; D051381:Rats; D017207:Rats, Sprague-Dawley
D003374:Coumarins; D005343:Fibrinolytic Agents; D009842:Oligopeptides; D010880:Piperidines; D010975:Platelet Aggregation Inhibitors; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; C102580:acetyl-aspartyl-glutamyl-valyl-aspartyl-amino-4-methylcoumarin; D001569:Benzodiazepines; C046617:arginyl-glycyl-aspartyl-serine; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases; C412702:lotrafiban