title: Tetanus antibody levels of female volunteers after injection with solvent/detergent-treated human tetanus immunoglobulin (Tetabulin S/D).
abstract: OBJECTIVE
  The aim of this study was to analyse the increase of antitetanus titre in volunteers following injection with human tetanus immunoglobulin (HTI).
  
  
  METHODS
  Twelve females with tetanus antibody titres of < or = 0.05 international units (IU)/ml were injected with 500 IU of human tetanus immunoglobulin (Tetabulin S/D). The tetanus antibody titres were determined before injection, and after 30 h, 48 h and 4 days.
  
  
  RESULTS
  A fast and sustained increase of protective tetanus antibody levels was observed in 10 of 12 volunteers. No adverse events related to the study drug were reported.
  
  
  CONCLUSIONS
  HTI confers rapid and effective immunity to tetanus.
authors.affiliation: Bio-Link AB, Götgatan 61, S-116 21 Stockholm, Sweden. bio-link@mbox318.swipnet.se
authors.forename: T
authors.initials: T
authors.lastname: Wahlberg
authors.forename: H
authors.initials: H
authors.lastname: Leibl
authors.forename: A
authors.initials: A
authors.lastname: Brauner
authors.forename: M
authors.initials: M
authors.lastname: Kirgios
authors.forename: N
authors.initials: N
authors.lastname: Adner
mesh_terms: D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D003902:Detergents / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000009:adverse effects / Q000302:isolation & purification; D008875:Middle Aged; D012997:Solvents / Q000494:pharmacology*; D013745:Tetanus Toxoid / Q000276:immunology; D014611:Vaccination
chemical_list: D000907:Antibodies, Bacterial; D003902:Detergents; D007136:Immunoglobulins; D012997:Solvents; C440498:Tetabulin S; D013745:Tetanus Toxoid