Sodium polyacrylate potentiates the anti-adhesion effect of a cellulose-derived polymer.
Available methods for postoperative adhesion prevention are insufficient. A previous study demonstrated that LM-200, a bioadhesive cellulose derivative was effective in reducing adhesions. Increasing the viscosity of a polymer solution enhances the tissue separating properties. Theoretically, a combination of sodium polyacrylate (PA) and LM-200 would give more viscous solutions than LM-200 alone, and thus be more efficacious. Therefore the efficacy of various combinations of LM-200 and PA was investigated. A lesion was created in the peritoneum of mice. The solutions to be tested, or saline, were given intraperitoneally. One week post-operatively, adhesion formation was quantified and expressed as a percentage of the original lesion covered with adhesions. PA (0.01 and 0.03 wt%) given separately did not differ in adhesion reducing effect from LM-200 (p = 0.3710 and 0.3481) but PA (0.1 wt%) resulted in significantly less adhesion formation (p = 0.0004). The effect of LM-200 increased significantly when adding PA (0.01 wt%) (p = 0.0007) or PA (0.03 wt%) (p < 0.0001). When adding PA (0.1 wt%) the effect was even more pronounced (p < 0.0001). The combination of a bioadhesive cellulose derivative and the polymer PA, was effective in reducing postoperative adhesion formation and a dose-dependent increase in efficacy was obtained compared to using the two components separately.
Falk
K
K
Department of Surgery, Sahlgrenska University Hospital/Ostra, University of Götehorg, Sweden.
Lindman
B
B
Bengmark
S
S
Larsson
K
K
Holmdahl
L
L
D000005:Abdomen; D000180:Acrylic Resins / Q000008:administration & dosage*; D000818:Animals; D001672:Biocompatible Materials; D002482:Cellulose / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D008422:Materials Testing; D051379:Mice; D011183:Postoperative Complications / Q000517:prevention & control; D012996:Solutions; D000267:Tissue Adhesions / Q000517:prevention & control*; D014014:Tissue Adhesives / Q000008:administration & dosage; D014783:Viscosity
D000180:Acrylic Resins; D001672:Biocompatible Materials; D012996:Solutions; D014014:Tissue Adhesives; C006903:carbopol 940; D002482:Cellulose