title: Tularemia epidemic in northwestern Spain: clinical description and therapeutic response.
abstract: This study describes the clinical characteristics of tularemia in Spain's first epidemic outbreak and the therapeutic response and compares the efficacy of 3 antibiotics (streptomycin, ciprofloxacin, and doxycycline). For 142 cases of tularemia, the therapeutic failure rate was 22.5%; ciprofloxacin was the antibiotic with the lowest percentage of therapeutic failures and with the fewest side effects.
authors.affiliation: Department of Internal Medicine, Rio Hortega Hospital, University of Valladolid, Cardenal Torquemada s/n, 47010 Valladolid, Spain. CASTRV@terra.es
authors.forename: J L
authors.initials: JL
authors.lastname: Pérez-Castrillón
authors.forename: P
authors.initials: P
authors.lastname: Bachiller-Luque
authors.forename: M
authors.initials: M
authors.lastname: Martín-Luquero
authors.forename: F J
authors.initials: FJ
authors.lastname: Mena-Martín
authors.forename: V
authors.initials: V
authors.lastname: Herreros
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000097:blood; D004196:Disease Outbreaks; D005260:Female; D005604:Francisella tularensis / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain / Q000453:epidemiology; D016896:Treatment Outcome; D014406:Tularemia / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial