Functional evaluation of peripheral nerve regeneration in the rat: walking track analysis.
The experimental model of choice for many peripheral nerve investigators is the rat. Walking track analysis is a useful tool in the evaluation of functional peripheral nerve recovery in the rat. This quantitative method of analyzing hind limbs performance by examining footprints, known as the sciatic function index (SFI), has been widely used to quantify functional recovery from sciatic nerve injury in a number of different injury models, although some limitations of the SFI has been questioned by several authors. This article is designed to offer the peripheral nerve investigator a noninvasive method to evaluate quantitatively the integrated motor recovery in experimental studies.
Varejão
A S
AS
Department of Pathology and Veterinary Clinics, UTAD, Vila Real, Portugal. avarejao@utad.pt
Meek
M F
MF
Ferreira
A J
AJ
Patrício
J A
JA
Cabrita
A M
AM
D000818:Animals; D004185:Disability Evaluation; D005684:Gait / Q000502:physiology*; D009069:Movement Disorders / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology; D009416:Nerve Regeneration / Q000502:physiology*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000503:physiopathology / Q000601:surgery*; D051381:Rats / Q000293:injuries / Q000502:physiology / Q000601:surgery; D020127:Recovery of Function / Q000502:physiology*