Prevalence of macrolide resistance genes in clinical isolates of the Streptococcus anginosus ("S. milleri") group.
Twenty-two unrelated erythromycin-resistant anginosus group strains (3.2% resistance rate) were assessed for mechanisms of resistance. Streptococcus anginosus accounted for 16 of the 22 isolates. Fifteen isolates harbored the erm(B) gene. The erm(TR) and the mef(E) genes were carried by two isolates each. In three isolates, none of these resistance genes was detected by PCR.
Jacobs
J A
JA
Department of Medical Microbiology, University Hospital Maastricht, Maastricht, The Netherlands. JJA@LMIB.azm.nl
van Baar
G J
GJ
London
N H
NH
Tjhie
J H
JH
Schouls
L M
LM
Stobberingh
E E
EE
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D004269:DNA, Bacterial / Q000032:analysis; D004352:Drug Resistance, Microbial / Q000235:genetics; D004917:Erythromycin / Q000494:pharmacology; D005798:Genes, Bacterial / Q000235:genetics*; D006801:Humans; D008780:Methyltransferases / Q000235:genetics; D016133:Polymerase Chain Reaction; D015995:Prevalence; D013291:Streptococcus / Q000187:drug effects / Q000235:genetics*
D000900:Anti-Bacterial Agents; D004269:DNA, Bacterial; D002981:Clindamycin; D004917:Erythromycin; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase