Does neuronal loss in Parkinson's disease involve programmed cell death?
Recently it has been hypothesized that apoptotic cell death is involved in several neuropathological conditions including Parkinson's disease (PD). Initial morphological studies assessing the presence of apoptosis in Parkinsonian brain tissues yielded mixed results. Based on more recent studies in human PD brains as well in animal and cell culture models of the disease, a picture is emerging, however, that strongly suggests that many of the molecular players thought to participate in this type of neuronal cell death are active in the disease. The task of researchers in the field is now to deduce how these players may be interacting with one another to bring about cell death in PD and to design effective therapies to interfere with these processes.
Andersen
J K
JK
Buck Institute for Age Research, 8001 Redwood Blvd. Novato, CA 94945, USA. jandersen@buckinstitute.org
D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000473:pathology; D018929:Cell Culture Techniques; D004195:Disease Models, Animal; D005978:Glutathione / Q000378:metabolism; D006801:Humans; D008928:Mitochondria; D009474:Neurons / Q000166:cytology*; D010300:Parkinson Disease / Q000473:pathology* / Q000628:therapy
D005978:Glutathione