Microwave-assisted [6+4]-cycloaddition of fulvenes and alpha-pyrones to azulene-indoles: facile syntheses of novel antineoplastic agents.
A microwave-enhanced [6+4]-cycloaddition reaction between 6-aminofulvene and pyrones followed by CO(2) extrusion provides azulene-indoles which display interesting antineoplastic activity.
Hong
B C
BC
Department of Chemistry, National Chung Cheng University, 621, Chia-Yi, Taiwan, ROC. chebch@ccunix.ccu.edu.tw
Jiang
Y F
YF
Kumar
E S
ES
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D052176:Azulenes; D003508:Cycloheptanes / Q000737:chemistry / Q000494:pharmacology*; D003517:Cyclopentanes / Q000138:chemical synthesis; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis / Q000494:pharmacology*; D020128:Inhibitory Concentration 50; D008872:Microwaves; D011753:Pyrones / Q000138:chemical synthesis; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured / Q000187:drug effects*
D000970:Antineoplastic Agents; D052176:Azulenes; D003508:Cycloheptanes; D003517:Cyclopentanes; D007211:Indoles; D011753:Pyrones; C017332:fulvene; C005525:azulene