Small is mighty: EmrE, a multidrug transporter as an experimental paradigm.
EmrE is a multidrug transporter from Escherichia coli that functions as a homooligomer and is unique in its small size. In each monomer there are four tightly packed transmembrane segments and one membrane-embedded charged residue. This residue provides the basis for the coupling mechanism as part of a binding site "time shared" by substrates and protons.
Schuldiner
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Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904 Jerusalem, Israel. shimon.schuldiner@huji.ac.il
Granot
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Mordoch
S S
SS
Ninio
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Rotem
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D
Soskin
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M
Tate
C G
CG
Yerushalmi
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H
D000595:Amino Acid Sequence / Q000235:genetics; D017920:Antiporters / Q000235:genetics / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology*; D029968:Escherichia coli Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D017920:Antiporters; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D004364:Pharmaceutical Preparations; C075436:EmrE protein, E coli