[Changes in serum levels of C-reactive protein and the soluble adhesion molecules, sE-selectin and sICAM-1, after transdermal 17-beta estradiol replacement].
OBJECTIVE
Increases in serum concentrations of C-reactive protein (CRP) and soluble adhesion molecules sE-selectin and sICAM-1 are regarded as risk factors of atherosclerosis now. We aimed to analyse an effect of estrogen replacement therapy (ERT) by transdermal 17-beta estrogen on the variables.


METHODS
A clinical study.


METHODS
Division of Gynaecology and Obstetrics, Hospital, Jicín and Department of Gynaecology and Obstetrics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.


METHODS
Serum concentrations of CRP (by immunoturbidimetry) and sE-selectin and sICAM-1 (both by ELISA test) were examined in 19 women (median age 50.0 years) after hysterectomy with both side adnexectomy before and after 4 months of continuous transdermal substitution by 17-beta estradiol (ERT) in 1.5 mg dose daily. Data were compared by paired t-test or by Wilcoxon test. P = 0.05, or below was taken as significant.


RESULTS
Serum concentration of C-reactive protein was decreased in treated women after 4 months of ERT (before ERT 1.82 +/- 2.20 mg/l, after 4 months of ERT 0.28 +/- 0.55 mg/l; p = 0.006) as well as both soluble adhesion molecules: sE-selectin (before ERT 45.13 +/- 17.3 micrograms/l, after 4 months of ERT 31.39 +/- 9.03 micrograms/l; p = 0.027) and sICAM-1 (before ERT 271.84 +/- 62.30 micrograms/l, after 4 months of ERT 242.86 +/- 62.32 micrograms/l; p = 0.026).


CONCLUSIONS
Transdermal substitution with 17-beta estradiol may reduce one of risk factor of atherogenesis in treated women after hysterectomy with both side adnexectomy.
Kvasnicka
J
J
Gynekologicko-porodnická klinika LF UK a Fakultní nemocnice v Hradci Králové.
Zivný
J
J
D000279:Administration, Cutaneous; D000290:Adnexa Uteri / Q000601:surgery; D001161:Arteriosclerosis / Q000517:prevention & control; D002097:C-Reactive Protein / Q000032:analysis*; D019040:E-Selectin / Q000097:blood*; D004958:Estradiol / Q000008:administration & dosage*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D007044:Hysterectomy; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008875:Middle Aged; D012307:Risk Factors
D019040:E-Selectin; D018799:Intercellular Adhesion Molecule-1; D004958:Estradiol; D002097:C-Reactive Protein