title: Long-term outcome of angioplasty for multivessel coronary disease: importance and price of complete revascularization.
abstract: BACKGROUND
  Complete revascularization of multivessel coronary artery disease (MVD) by coronary artery bypass surgery has been shown to improve outcome, but there is a lack of similar data for patients treated by angioplasty.
  
  
  METHODS
  Therefore, a consecutive series of 250 patients with MVD was separated into two groups, those with complete revascularization (n=101) and those with incomplete revascularization (n=149). Six-month 'clinical restenosis' rate assessed by stress myocardial perfusion scintigraphy or symptom-driven angiography and long-term 32 months outcome were compared with an equally sized group of single vessel disease (SVD) patients.
  
  
  RESULTS
  MVD patients with complete revascularization had a higher 'clinical restenosis' rate than patients with SVD (35 vs. 22%, P<0.02), although restenosis rate per treated vessel was similar (23%, 18%, P NS). If this higher early restenosis rate were accepted as 'price' for complete MVD angioplasty, long-term event-free survival was no longer different from that of SVD patients (86 vs. 93%, P NS). In contrast, patients with incomplete multivessel angioplasty had a significantly worse long-term outcome (22% events), especially if initially untreated, non-occluded vessels remained untreated (25% events).
  
  
  CONCLUSIONS
  MVD angioplasty with complete revascularization has a long-term event-free survival similar to that of SVD angioplasty but at the price of a higher rate of 6-month restenosis and repeat interventions.
authors.affiliation: Division of Cardiology, Department of Internal Medicine, University Hospital, Basel, Switzerland.
authors.forename: U C
authors.initials: UC
authors.lastname: Kloeter
authors.forename: N G
authors.initials: NG
authors.lastname: Jander
authors.forename: P T
authors.initials: PT
authors.lastname: Buser
authors.forename: S
authors.initials: S
authors.lastname: Osswald
authors.forename: J
authors.initials: J
authors.lastname: Mueller-Brand
authors.forename: M E
authors.initials: ME
authors.lastname: Pfisterer
mesh_terms: D015906:Angioplasty, Balloon, Coronary / Q000379:methods* / Q000401:mortality; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000401:mortality / Q000628:therapy*; D018572:Disease-Free Survival; D005260:Female; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D015607:Stents; D013557:Switzerland / Q000453:epidemiology; D016896:Treatment Outcome