Interstitial granulomatous dermatitis with cutaneous cords and arthritis: a disorder associated with autoantibodies.
Interstitial granulomatous dermatitis with arthritis is a new entity characterized by linear or arciform subcutaneous cords. We describe a patient presenting with typical cutaneous lesions extending from the anterior and posterior part of the axillae to the flank. The lesions had been present for 6 years with flares and remission. Histopathologic examination revealed a bandlike infiltrate of histiocytes in the reticular dermis with focal areas of palisading around necrotic collagen bundles. A few atypical histiocytes were also present. As previously described, it was associated with serologic findings of an autoimmune disease, especially high titers of anti-DNA antibodies. The possible inclusion of the interstitial granulomatous dermatitis in the continuous spectrum of the palisaded neutrophilic and granulomatous dermatitis of immune complex disease is also discussed.
Verneuil
L
L
Dermatology Service, Centre Hospitalier Universitaire, Caen, France.
Dompmartin
A
A
Comoz
F
F
Pasquier
C J
CJ
Leroy
D
D
D000368:Aged; D001168:Arthritis / Q000150:complications* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology / Q000473:pathology*; D001365:Axilla; D003094:Collagen / Q000648:ultrastructure; D003872:Dermatitis / Q000276:immunology / Q000473:pathology; D020405:Dermis / Q000473:pathology; D003937:Diagnosis, Differential; D006099:Granuloma / Q000150:complications / Q000276:immunology / Q000473:pathology*; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D008297:Male; D012871:Skin Diseases / Q000150:complications / Q000276:immunology / Q000473:pathology*; D013909:Thorax
D001323:Autoantibodies; D003094:Collagen