title: [Significance of argyrophilic proteins of the nucleolar organizer region in differentiation of benign and malignant growth of thyroid epithelial tumors].
abstract: Argyrophilic proteins of nucleolar organizers (NO) were measured in 47 benign (24 follicular and 8 atypical adenomas) and malignant (8 papillary and 7 follicular carcinomas) tumors. The content of argyrophilic NO proteins was significantly higher in malignant cells. The proportion of cells with at least 5 silver grains per cell was 16.8 and 22.8% in follicular and papillary carcinoma, respectively, and 3.2 and 12% in follicular and atypical adenoma, respectively. These data can be used as accessory signs in differential diagnosis.
authors.affiliation: N. N. Blokhin Cancer Research Center, 115478, Moscow.
authors.forename: I A
authors.initials: IA
authors.lastname: Bukaeva
authors.forename: E A
authors.initials: EA
authors.lastname: Smirnova
authors.forename: A I
authors.initials: AI
authors.lastname: Pavlovskaia
authors.forename: M A
authors.initials: MA
authors.lastname: Makanin
authors.forename: I G
authors.initials: IG
authors.lastname: Ol'khovskaia
authors.forename: N T
authors.initials: NT
authors.lastname: Raĭkhlin
mesh_terms: D014408:Biomarkers, Tumor; D006801:Humans; D009375:Neoplasms, Glandular and Epithelial / Q000378:metabolism / Q000473:pathology*; D009687:Nuclear Proteins / Q000378:metabolism; D009697:Nucleolus Organizer Region / Q000378:metabolism / Q000473:pathology; D013194:Staining and Labeling; D013964:Thyroid Neoplasms / Q000378:metabolism / Q000473:pathology*
chemical_list: D014408:Biomarkers, Tumor; D009687:Nuclear Proteins