title: Pathogenic aspects of pyogenic liver abscess associated with experimental schistosomiasis.
abstract: Schistosomiasis mansoni infection that occurs concurrently with Staphylococcus aureus bacteremia favors the formation of pyogenic liver abscess. The present experimental study in mice evaluated the following aspects of the relationship between infection with Schistosoma mansoni and liver abscess caused by S. aureus: a) the role of the eggs of S. mansoni in the genesis of the abscesses; b) the influence of different phases of schistosomiasis in the development of liver abscesses; and c) the effect of the treatment of schistosomiasis on the development of the abscesses. Macroscopic and histopathological study showed multiple liver abscesses around granulomas of S. mansoni in the acute and chronic phases of schistosomiasis. Treatment of acute schistosomiasis before experimentally-induced bacteremia did not prevent the formation of liver abscess. The study findings indicate that granulomas around S. mansoni eggs and worms lodged in the liver provide a focus and substrate for pyogenic abscesses caused by S. aureus.
authors.affiliation: Department of Internal Medicine and Pathology, School of Medicine, Federal University of Minas Gerais, Brazil.
authors.forename: R
authors.initials: R
authors.lastname: Teixeira
authors.forename: P M
authors.initials: PM
authors.lastname: Coelho
authors.forename: G
authors.initials: G
authors.lastname: Brasileiro Filho
authors.forename: G M
authors.initials: GM
authors.lastname: Azevedo Junior
authors.forename: J C
authors.initials: JC
authors.lastname: Serufo
authors.forename: F J
authors.initials: FJ
authors.lastname: Pfeilsticker
authors.forename: F P
authors.initials: FP
authors.lastname: Abreu
authors.forename: C P
authors.initials: CP
authors.lastname: Costa
authors.forename: F J
authors.initials: FJ
authors.lastname: Pfeilsticker
authors.forename: G D
authors.initials: GD
authors.lastname: Santa Cecilia
authors.forename: J R
authors.initials: JR
authors.lastname: Lambertucci
mesh_terms: D000208:Acute Disease; D000818:Animals; D002908:Chronic Disease; D008100:Liver Abscess / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D051379:Mice; D010073:Oxamniquine / Q000627:therapeutic use; D012552:Schistosomiasis / Q000150:complications / Q000188:drug therapy / Q000473:pathology*; D012556:Schistosomicides / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000150:complications
chemical_list: D012556:Schistosomicides; D010073:Oxamniquine