title: Physiopathological effects of the administration of chronic cyanide to growing goats--a model for ingestion of cyanogenic plants.
abstract: Ingestion of cyanogenic plants, such as cassava and sorghum, has been associated with goitre and tropical pancreatic diabetes in both humans and animals. Thus, the objective of the present study was to determine the toxic effects on the thyroid and pancreas in growing goats of prolonged exposure to potassium cyanide (KCN). Thirty-four male goats were divided into five groups dosed with KCN at 0 (control). 0.3, 0.6, 1.2 or 3.0 mg/kg daily for 5 months. Blood samples were obtained in order to determine the glucose, cholesterol, thyroxine (T4), triiodothyronine (T3) and thiocyanate concentrations and for haematological studies; pancreas and thyroid gland were collected for histopathological study. The group receiving the highest dose of cyanide showed lower body weight gains and carcase weights and a decrease in plasma T3 concentrations compared to the control group. Reabsorption vacuoles in follicular colloid and normocytic normochromic anaemia were observed in the experimental animals. Inhibition of peripheral conversion of T4 to T3 is suggested. However, no diabetogenic effects were observed.
authors.affiliation: Department of Pathology, School of Veterinary Medicine, University of São Paulo, SP, Brazil.
authors.forename: B
authors.initials: B
authors.lastname: Soto-Blanco
authors.forename: S L
authors.initials: SL
authors.lastname: Górniak
authors.forename: E T
authors.initials: ET
authors.lastname: Kimura
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004906:Erythrocyte Count / Q000662:veterinary; D006041:Goats / Q000378:metabolism*; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007958:Leukocyte Count / Q000662:veterinary; D008297:Male; D002365:Manihot / Q000633:toxicity; D010179:Pancreas / Q000187:drug effects* / Q000473:pathology; D011190:Potassium Cyanide / Q000008:administration & dosage / Q000633:toxicity*; D013861:Thiocyanates / Q000097:blood; D013961:Thyroid Gland / Q000187:drug effects* / Q000473:pathology; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine
chemical_list: D001786:Blood Glucose; D006454:Hemoglobins; D013861:Thiocyanates; D014284:Triiodothyronine; D002784:Cholesterol; D011190:Potassium Cyanide; C031760:thiocyanate; D013974:Thyroxine