title: Routine testing of liver function after biliary-enteric anastomosis has no clinical relevance.
abstract: OBJECTIVE
  Patients who had a biliary-enteric anastomosis often have elevated liver function tests. The aim of this study was to investigate whether elevated liver function tests are associated with recurrent episodes of cholangitis.
  
  
  METHODS
  Thirty-two patients, who received a biliary-enteric anatomosis for benign biliary disease were evaluated. Follow-up consisted of the patient's history, physical examination, determination of liver function tests, ultrasonography and hepatobiliary scintigraphy using 99mTc-HIDA.
  
  
  RESULTS
  Median duration of follow-up was 45 months (range: 1-192) and liver function tests were elevated in 22 patients (69%) at some time during follow-up. Dilated intrahepatic ducts were found in 3 of 30 patients (10%), all of whom had elevated liver function tests at follow-up. Delayed passage from the liver was observed using scintigraphy in 10 (31%) of the patients. Seven patients (22%) experienced one episode of cholangitis and none experienced more than one episode. Multivariate analysis showed that male sex was an independent risk factor for elevated liver function tests (odds ratio: 10.9; P < 0.05). For cholangitis, no risk factors could be identified.
  
  
  CONCLUSIONS
  It is concluded that elevated liver function tests are relatively common after a biliary-enteric anastomosis for benign biliary tract disease and are not predictive of the occurrence of cholangitis. We, therefore, recommend omitting routine laboratory screening for elevated liver function tests in the follow-up of a biliary-enteric anastomosis.
authors.affiliation: Department of General Surgery, University Hospital Rotterdam, Rotterdam, The Netherlands.
authors.forename: P W
authors.initials: PW
authors.lastname: Plaisier
authors.forename: R L
authors.initials: RL
authors.lastname: van der Hul
authors.forename: J S
authors.initials: JS
authors.lastname: Laméris
authors.forename: H Y
authors.initials: HY
authors.lastname: Oei
authors.forename: O T
authors.initials: OT
authors.lastname: Terpstra
mesh_terms: D000328:Adult; D000368:Aged; D001653:Bile Ducts, Intrahepatic; D002761:Cholangitis / Q000175:diagnosis*; D002768:Choledochostomy; D001651:Cholestasis, Extrahepatic / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D011237:Predictive Value of Tests; D012008:Recurrence