title: Potential therapeutic effect of simvastatin on progressive renal failure and nephrotic-range proteinuria caused by renal cholesterol embolism.
abstract: We report our experience with a 62-year-old Japanese man with cholesterol crystal embolism after angiographic procedures performed because of intermittent claudication. In addition to progressive renal failure and nephrotic-range proteinuria, cutaneous ischemia, consisting of livedo reticularis in the lower limbs and digital necrosis at the tip of the right toe, and fundoscopic findings showing several white spots in the branches of retinal artery were also observed. Progressive renal failure and nephrotic-range proteinuria were halted just after treatment with simvastatin. Thus, simvastatin can exert a beneficial therapeutic effect on renal cholesterol embolism.
authors.affiliation: Hemodialysis Unit, Hamamatsu University School of Medicine, Japan. katsuh@hama-med.ac.jp
authors.forename: K
authors.initials: K
authors.lastname: Yonemura
authors.forename: N
authors.initials: N
authors.lastname: Ikegaya
authors.forename: Y
authors.initials: Y
authors.lastname: Fujigaki
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: A
authors.initials: A
authors.lastname: Togawa
authors.forename: A
authors.initials: A
authors.lastname: Hishida
mesh_terms: D000924:Anticholesteremic Agents / Q000097:blood / Q000627:therapeutic use*; D003404:Creatinine / Q000097:blood; D018450:Disease Progression; D017700:Embolism, Cholesterol / Q000097:blood / Q000150:complications*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009401:Nephrosis / Q000097:blood / Q000150:complications* / Q000209:etiology; D011507:Proteinuria / Q000097:blood / Q000150:complications* / Q000209:etiology; D019821:Simvastatin / Q000097:blood / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000924:Anticholesteremic Agents; D019821:Simvastatin; D003404:Creatinine