Modification of gold surface by grafting of poly(ethylene glycol) for reduction in protein adsorption and platelet adhesion.
Gold surfaces were first treated in an alkanethiol solution to form self-assembled monolayers (SAMs). The thiolated Au surface was then subjected to Ar plasma pretreatment, followed by air exposure and UV-induced graft polymerization of poly(ethylene glycol) methacrylate (PEGMA) macromonomer. In comparison with the 3-mercaptopropionic acid-2-ethylhexyl ester (MPAEE) SAM, the (3-mercaptoproply)trimethoxysilane (MPTMS) SAM on Au exhibited higher stability under the conditions of Ar plasma pretreatment. The graft concentration of the PEGMA polymer on SAM-modified Au surface increased with increasing PEGMA macromonomer concentration and UV-graft polymerization time. The modified-Au surfaces were characterized by X-ray spectroscopy (XPS), atomic force microscopy (AFM), and water contact angle measurement. The Au surface with a high concentration of grafted PEGMA polymer could completely repel protein adsorption and platelet adhesion.
Zhang
F
F
Department of Chemical Engineering, National University of Singapore, Kent Ridge Crescent.
Kang
E T
ET
Neoh
K G
KG
Huang
W
W
D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000528:radiation effects; D004285:Dogs; D004577:Electron Probe Microanalysis; D006046:Gold / Q000737:chemistry* / Q000528:radiation effects; D007834:Lasers; D008722:Methods; D008855:Microscopy, Electron, Scanning; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000737:chemistry* / Q000528:radiation effects; D011506:Proteins / Q000378:metabolism*; D013499:Surface Properties; D014466:Ultraviolet Rays
D001672:Biocompatible Materials; D011506:Proteins; D011092:Polyethylene Glycols; D006046:Gold