title: CCK and development of mother preference in sheep: a neonatal time course study.
abstract: We investigated the effects of a CCK-A receptor antagonist on the development of mother preference. Lambs received 2-NAP either at birth or 6, or 12 h later. Controls were given saline. When tested at 24 h of age, lambs receiving 2-NAP at birth or 6 h later did not display mother preference unlike controls and lambs which were given 2-NAP at 12 h. The effect of the antagonist persisted at 48 h of age in lambs treated at birth. This suggests that endogenous CCK participates in the development of mother preference only in the first few hours following birth.
authors.affiliation: Equipe de Comportement Animal, UMR6073 CNRS/INRA/Université de Tours, Unité de Physiologie de la Reproduction et des Comportements, 37380 Nouzilly, France. Nowak@tours.inra.fr
authors.forename: R
authors.initials: R
authors.lastname: Nowak
authors.forename: G
authors.initials: G
authors.lastname: Breton
authors.forename: E
authors.initials: E
authors.lastname: Mellot
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002766:Cholecystokinin / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000494:pharmacology*; D005260:Female; D009035:Mothers; D009282:Naphthalenesulfonates / Q000378:metabolism / Q000494:pharmacology*; D012756:Sheep; D013997:Time Factors
chemical_list: D009282:Naphthalenesulfonates; C080661:N-(2-naphthalenesulfonyl)aspartyl-(2-phenethyl)amide; D001224:Aspartic Acid; D002766:Cholecystokinin