title: In vitro and In vivo inhibition of LPS-stimulated tumor necrosis factor-alpha secretion by the gallotannin beta-D-pentagalloylglucose.
abstract: The naturally occurring gallotannin beta-D-pentagalloylglucose (beta-PGG) decreases tumor necrosis factor-alpha (TNF-alpha) output from human peripheral blood mononucleocytes exposed to lipopolysaccharide (LPS) by as much as 90% (vs control) at approximately 5 microM concentration. A qualitatively similar but less pronounced effect ( approximately 50% decrease) was observed in the serum of rats dosed with both LPS and beta-PGG. These results may have relevance to therapies that target disease states characterized by an overproduction of TNF-alpha.
authors.affiliation: Department of Chemistry, The Pennsylvania State University, University Park, 16802, PA, USA. ksf@chem.psu.edu
authors.forename: K S
authors.initials: KS
authors.lastname: Feldman
authors.forename: K
authors.initials: K
authors.lastname: Sahasrabudhe
authors.forename: M D
authors.initials: MD
authors.lastname: Lawlor
authors.forename: S L
authors.initials: SL
authors.lastname: Wilson
authors.forename: C H
authors.initials: CH
authors.lastname: Lang
authors.forename: W J
authors.initials: WJ
authors.lastname: Scheuchenzuber
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D047348:Hydrolyzable Tannins / Q000031:analogs & derivatives / Q000494:pharmacology*; D007375:Interleukin-1 / Q000819:agonists* / Q000097:blood; D007963:Leukocytes, Mononuclear / Q000378:metabolism; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051381:Rats; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D001685:Biological Factors; D047348:Hydrolyzable Tannins; D007375:Interleukin-1; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha; C435084:pentagalloylglucose