Effect of garlic (Allium sativum L.) extract on tissue lead level in rats.
The prophylactic efficacy of garlic (Allium sativum L.) extract to reduce tissue lead (Pb) concentration was evaluated experimentally in rats. Thirty female rats were divided into five groups, keeping group A as a healthy control. Rats of groups B, C, D and E received lead acetate orally at the rate of 5 mg per kg body weight daily for 6 weeks. The garlic extract was tried in three doses, viz. 100 (low), 200 (medium) and 400 mg (high) per kg body weight orally and given simultaneously with lead salt to the rats of group C, D and E, respectively. Mean blood lead concentrations in lead-exposed rats ranged between 0.13+/-0.02 and 0.96+/-0.06 microg/ml, whereas in garlic-treated rats, the range was between 0.16+/-0.01 and 0.80+/-0.05; 0.13+/-0.01 and 0.71+/-0.06 and 0.14+/-0.01 and 0.60+/-0.05 microg per ml in low, medium and high dose groups, respectively. The mean lead concentration in liver, kidneys, brain and bone of lead exposed rats was 2.943+/-0.206, 4.780+/-0.609, 1.019+/-0.100 and 44.075+/-2.60 microg per ml, respectively. Concomitant use of garlic extract at the three different doses was found to reduce lead concentration considerably indicating the potential therapeutic activity of garlic against lead.
Senapati
S K
SK
Laboratory of Comparative System of Medicine, Division of Medicine, Indian Veterinary Research Institute, Izatnagar, 243 122 U.P., India.
Dey
S
S
Dwivedi
S K
SK
Swarup
D
D
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005269:Femur / Q000187:drug effects / Q000378:metabolism; D005737:Garlic; D007194:India; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D007854:Lead / Q000097:blood*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009942:Organometallic Compounds / Q000008:administration & dosage; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D018514:Plant Structures; D010946:Plants, Medicinal; D051381:Rats; D014018:Tissue Distribution
D009942:Organometallic Compounds; D010936:Plant Extracts; D007854:Lead; C008261:lead acetate