Inhibition of the contraction of collagen gels by extracts from human dermis.
Extracts from the human dermis were prepared and evaluated with respect to their ability to influence fibroblasts to contract collagen gels in vitro. The extract which had the most inhibitory effect on fibroblasts to cause contraction of collagen gels was extract D. It also inhibited fibroblast growth. Inhibition of contraction was not simply related to fibroblast cell numbers and the data suggests a specific effect upon the ability of fibroblasts to cause contraction. Other extracts were without significant effect.
El-Sheemy
M A
MA
Department of Surgery, University of Aberdeen Medical School, Polwarth Building, Foresterhill, Aberdeen AB25 2ZD, UK. mohamed.el-sheemy@llh-tr.trent.nhs.uk
Muir
I F
IF
Wheatley
D N
DN
Eremin
O
O
D002455:Cell Division / Q000187:drug effects; D003094:Collagen / Q000502:physiology*; D003470:Culture Media; D020405:Dermis / Q000502:physiology*; D005260:Female; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D014020:Tissue Extracts / Q000494:pharmacology; D014945:Wound Healing
D003470:Culture Media; D014020:Tissue Extracts; D003094:Collagen