Immunologically active polysaccharides from Centrosema pubescens.
Two polysaccharides with mean M(r)s of 2.0 x 10(6) and 3.75 x 10(5), were isolated from powdered seeds of Centrosema pubescens by fractionation on Sephacryl S-300 HR. Chemical and spectroscopic studies indicated that they have a backbone chain composed of beta-(1-->4)-linked D-galactopyranose residues having branches composed of alpha-(1-->5)-linked L-arabinofuranose residues at position 6 of D-galactose of the backbone chain. The polysaccharides showed reticuloendothelial system-potentiating activity in a carbon clearance test.
da Silva
B P
BP
Universidade Federal do Rio de Janerio, PO Box 68045, 21944-970 Rio de Janeiro, Brazil.
Tostes
J B
JB
Parente
J P
JP
D000818:Animals; D006801:Humans; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification; D010946:Plants, Medicinal; D011134:Polysaccharides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D019685:Rosales; D012639:Seeds
D010936:Plant Extracts; D011134:Polysaccharides