title: Increased serum levels of interleukin-18 in patients with multiple sclerosis.
abstract: Serum but not CSF concentrations of the interferon-gamma-inducing cytokine interleukin (IL)-18 were significantly augmented in patients with MS as compared to both healthy controls and patients with other neurologic diseases. Patients with MS with secondary chronic progressive disease had significantly higher serum levels than those with relapsing remitting MS. In the latter group, IL-18 levels were higher in patients with acute exacerbation as compared to those with stable disease.
authors.affiliation: Institute of Microbiology, University of Milan Bicocca, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Nicoletti
authors.forename: R
authors.initials: R
authors.lastname: Di Marco
authors.forename: K
authors.initials: K
authors.lastname: Mangano
authors.forename: F
authors.initials: F
authors.lastname: Patti
authors.forename: E
authors.initials: E
authors.lastname: Reggio
authors.forename: A
authors.initials: A
authors.lastname: Nicoletti
authors.forename: K
authors.initials: K
authors.lastname: Bendtzen
authors.forename: A
authors.initials: A
authors.lastname: Reggio
mesh_terms: D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D020382:Interleukin-18 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*
chemical_list: D020382:Interleukin-18