Phosphatidylinositol 3' kinase signaling in mammary tumorigenesis.
Suppression of apoptosis is now recognized as a key contributory element to tumorigenesis in animal models and human cancer. The phosphatidylinositol 3' kinase pathway plays a seminal role in cell death suppression or "survival signaling." Over the past 5 years, the molecular mechanisms by which this pathway exerts its death suppressive effects have slowly been revealed. This review summarizes the players involved, their importance in human cancer and their specific involvement in breast cancer.
Scheid
M P
MP
Ontario Cancer Institute, Toronto, Canada.
Woodgett
J R
JR
D000818:Animals; D005260:Female; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000201:enzymology*; D019869:Phosphatidylinositol 3-Kinases / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D019869:Phosphatidylinositol 3-Kinases