An emerging role for co-receptors in inhibin signal transduction.
While many transforming growth factor-beta (TGFbeta) superfamily ligands such as TGFbeta, activin, and the bone morphogenic proteins (BMPs) are critical to the control of growth, differentiation, and cell fate, inhibin has a more limited role and is primarily responsible for the regulation of one hormone from one cell-type in the anterior pituitary. Inhibin is an endocrine hormone, produced by the gonads, that inhibits follicle stimulating hormone (FSH) release from the pituitary gonadotrope. The other hormones in the superfamily do not appear to act in an endocrine fashion, but rather control cell function in a paracrine or autocrine manner. Many components of the TGFbeta/activin/BMP signal transduction pathway have been elegantly defined; however, the mechanism of inhibin action has not been completely dissected. Several cell surface proteins that associate with inhibin have been identified recently, and these molecules may provide the clues necessary to understand how inhibin regulates reproductive function.
Bernard
D J
DJ
Department of Neurobiology and Physiology, Northwestern University, O.T. Hogan 4-150, 2153 N. Campus Drive, 60208, Evanston, IL, USA.
Chapman
S C
SC
Woodruff
T K
TK
D029404:Activin Receptors / Q000502:physiology*; D028341:Activins / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D006801:Humans; D007265:Inhibins / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology*; D010902:Pituitary Gland / Q000187:drug effects; D011485:Protein Binding; D011509:Proteoglycans / Q000378:metabolism; D018000:Receptors, Peptide / Q000502:physiology*; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism; D015398:Signal Transduction / Q000187:drug effects
D011509:Proteoglycans; D018000:Receptors, Peptide; D018125:Receptors, Transforming Growth Factor beta; D028341:Activins; C071736:betaglycan; D007265:Inhibins; D029404:Activin Receptors