Synthesis of 5-fluorouracil-imprinted polymers with multiple hydrogen bonding interactions.
The antitumor active compound 5-fluorouracil (5-FU) was used as a target molecule and 5-FU-imprinted polymers were synthesized using 2,6-bis(acrylamido)pyridine and/or 2-(trifluoromethyl)acrylic acid as functional monomers. The 5-FU-imprinted polymers showed a higher affinity for 5-FU than that for 5-FU derivatives. By using both functional monomers simultaneously, the affinity and separation for 5-FU were improved.
Kugimiya
A
A
Laboratory of Synthetic Biochemistry, Faculty of Information Sciences, Hiroshima City University, 3-4-1 Ozuka-higashi, Asaminami-ku, Hiroshima 731-3194, Japan.
Mukawa
T
T
Takeuchi
T
T
D005472:Fluorouracil / Q000032:analysis* / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D011108:Polymers
D011108:Polymers; D005472:Fluorouracil