Biological applications of hammerhead ribozymes as anti-viral molecules.
Ribozymes are catalytic RNAs that can cleave substrate RNAs in a sequence specific manner. Here we survey, in brief, the structure of hammerhead and hairpin ribozymes and discuss their applications as molecular antiviral molecules for HIV-1.
Lustig
B
B
Department of Chemistry, San Jose State University, San Jose, CA 95192, USA.
Jeang
K T
KT
D000998:Antiviral Agents / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D012313:RNA / Q000378:metabolism; D016337:RNA, Catalytic / Q000378:metabolism / Q000494:pharmacology*
D000998:Antiviral Agents; D016337:RNA, Catalytic; C418481:hairpin ribozyme; C427204:hammerhead ribozyme; D012313:RNA