New and efficient routes to biomolecules substituted with cyclopentadienyltricarbonylrhenium and -technetium derivatives.
The small, compact, robust, and nonpolar units of [CpM(CO)3] (M = Re, Tc) coupled with biomolecules may be considered as bioorganometallic entities of potential interest in the field of medicinal chemistry. However, the short half-life of useful radionuclides (186Re t1/2 = 3.7 d, 188Re t1/2 = 16.8 h, 99mTc t1/2 = 6 h), the risks inherent in their use, and their cost have led chemists to search for novel synthetic strategies that allow the rapid introduction of the [CpM(CO)3] moiety as a late step in the course of synthesizing the target molecule. The present paper describes different strategies recently reported in the literature to tackle this problem.
Le Bideau
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UMR 7576 CNRS, Ecole Nationale Supérieure de Chimie de Paris, France.
Salmain
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Top
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Jaouen
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D001943:Breast Neoplasms / Q000188:drug therapy; D002626:Chemistry, Pharmaceutical / Q000379:methods; D003517:Cyclopentanes / Q000737:chemistry*; D004967:Estrogens / Q000138:chemical synthesis* / Q000737:chemistry; D006207:Half-Life; D015394:Molecular Structure; D015282:Octreotide / Q000737:chemistry; D009942:Organometallic Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000737:chemistry; D011506:Proteins / Q000737:chemistry; D011868:Radioisotopes / Q000737:chemistry*; D019275:Radiopharmaceuticals / Q000138:chemical synthesis* / Q000737:chemistry; D012211:Rhenium / Q000737:chemistry*; D020845:Selective Estrogen Receptor Modulators / Q000737:chemistry; D013329:Structure-Activity Relationship; D013629:Tamoxifen / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry / Q000627:therapeutic use; D017256:Technetium Tc 99m Sestamibi / Q000737:chemistry
D003517:Cyclopentanes; D004967:Estrogens; D009942:Organometallic Compounds; D015609:Organotechnetium Compounds; D010455:Peptides; D011506:Proteins; D011868:Radioisotopes; D019275:Radiopharmaceuticals; D020845:Selective Estrogen Receptor Modulators; D013629:Tamoxifen; C017332:fulvene; D012211:Rhenium; D017256:Technetium Tc 99m Sestamibi; D015282:Octreotide