[Clinical pharmacology of angiotensin II receptor antagonists].
Angiotensin II is not only generated by the circulating ACE (Angiotensin II converting enzyme) but also locally in several tissues. Therefore substances were developed, which act directly at its receptor. This receptor contains 2 subtypes, which are influenced by these antagonists in a different way. The marketed drugs of this group have different pharmacokinetic properties.
Hitzenberger
G
G
Gesellschaft für klinische Pharmakologie, Kinderspitalgasse 10/16, A-1090 Wien. bluthochdruck@eunet.at
D000804:Angiotensin II / Q000037:antagonists & inhibitors / Q000187:drug effects*; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects / Q000493:pharmacokinetics / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D011945:Receptors, Angiotensin / Q000378:metabolism
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D011945:Receptors, Angiotensin; D000804:Angiotensin II