Erythrocyte membrane fluidity changes in psoriasis: an EPR study.
The aim of the study was to find the cause of membrane fluidity decrease in psoriasis, observed by other authors, in different types of cells and its clinical consequences. To this end, we have examined the influence of different clinical and biochemical factors on erythrocyte membrane fluidity changes in psoriatic patients. Membrane fluidity was studied by the electron paramagnetic resonance spin-labeling method. The data revealed that the decrease of membrane fluidity corresponded with exacerbation of skin lesions. The results clearly indicate that the increased lipid peroxidation may be the essential mechanism of membrane fluidity decrease in psoriasis.
Górnicki
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Department of Biophysics, The Ludwig Rydygier University of Medical Sciences in Bydgoszcz, Jagiellonska 13, 85-067, Bydgoszcz, Poland. agor@aci.amb.bydgoszcz.pl
Gutsze
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D002374:Catalase / Q000097:blood; D004578:Electron Spin Resonance Spectroscopy; D004910:Erythrocyte Membrane / Q000502:physiology*; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008315:Malondialdehyde / Q000097:blood; D008560:Membrane Fluidity; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000503:physiopathology; D012016:Reference Values; D012720:Severity of Illness Index; D013482:Superoxide Dismutase / Q000097:blood
D008054:Lipid Peroxides; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase