title: A novel application of NMR microscopy: measurement of water diffusion inside bioadhesive bonds.
abstract: The self-diffusion coefficient of water (D) inside bioadhesive bonds formed by dry and prehydrated hydrophilic matrices has been spatially resolved using nuclear magnetic resonance (NMR) microscopy. One-dimensional profiles showing the variation of D inside bioadhesive bonds were calculated from nine diffusion-weighted profiles obtained immediately after bond formation and every 5 min for 30 min. The resulting data indicated that the hydration state of a hydrophilic matrix can significantly and dramatically influence the dynamics of water movement inside a bioadhesive bond.
authors.affiliation: Institute of Pharmaceutical Sciences, University of Nottingham, NG7 2RD, Nottingham, UK. paul.marshall@reckittbenckiser.com
authors.forename: P
authors.initials: P
authors.lastname: Marshall
authors.forename: J E
authors.initials: JE
authors.lastname: Snaar
authors.forename: Y L
authors.initials: YL
authors.lastname: Ng
authors.forename: R W
authors.initials: RW
authors.lastname: Bowtell
authors.forename: F C
authors.initials: FC
authors.lastname: Hampson
authors.forename: P W
authors.initials: PW
authors.lastname: Dettmar
authors.forename: C D
authors.initials: CD
authors.lastname: Melia
mesh_terms: D003681:Dehydration; D004058:Diffusion; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009077:Mucins / Q000737:chemistry; D012212:Rheology; D014867:Water
chemical_list: D009077:Mucins; D014867:Water