Oxidation of isoniazid by manganese and Mycobacterium tuberculosis catalase-peroxidase yields a new mechanism of activation.
Bodiguel
J
J
MAEM UMR mixte CNRS-UHP no 7567 Faculté des Sciences Université H. Poincaré Nancy I Bld. des Aiguillettes BP 239 F-54506 Vandoeuvre-lès-Nancy, France.
Nagy
J M
JM
Brown
K A
KA
Jamart-Grégoire
B
B
D000995:Antitubercular Agents / Q000737:chemistry*; D001426:Bacterial Proteins; D002413:Cations, Divalent; D004789:Enzyme Activation; D007538:Isoniazid / Q000737:chemistry*; D008345:Manganese / Q000737:chemistry; D009169:Mycobacterium tuberculosis / Q000201:enzymology*; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000737:chemistry / Q000378:metabolism*
D000995:Antitubercular Agents; D001426:Bacterial Proteins; D002413:Cations, Divalent; D008345:Manganese; D010544:Peroxidases; C081610:catalase-peroxidase, bacteria; D007538:Isoniazid