Enantiospecific pharmacokinetics of ketoprofen in plasma and synovial fluid of horses with acute synovitis.
Pharmacokinetic parameters were established for enantiomers of the nonsteroidal anti-inflammatory drug (NSAID) ketoprofen (KTP) administered as the racemic mixture at a dose of 2.2 mg/kg and as separate enantiomers, each at a dose of 1.1 mg/kg to a group of six horses (five mares and one gelding). A four-period cross-over study in a LPS-induced model of acute synovitis was used. After administration of the racemic mixture S(+)KTP was the predominant enantiomer in plasma as well as in synovial fluid. Unidirectional inversion of R(-) to S(+)KTP was demonstrated but the inversion was less marked than previously reported. It is suggested that this reduction could be because of the influence of the inflammatory reaction on hepatic metabolism. The disposition of KTP enantiomers after administration of the racemic mixture was similar to those observed after administration of S(+) and R(-)KTP. The S(+) and R(-)KTP concentrations in synovial fluid were low and short lasting. After administration of R(-)KTP significant concentrations of the optical antipode were detected in synovial fluid.
Verde
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CR
Cátedra de Farmacología, Facultad de Ciencias Veterinarias, Universidad Nacional de La Plata, Calle 60 y 118 cc 296 (1900) La Plata, Argentina.
Simpson
M I
MI
Frigoli
A
A
Landoni
M F
MF
D000208:Acute Disease; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D019540:Area Under Curve; D002350:Carpus, Animal; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D018592:Cross-Over Studies; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy / Q000378:metabolism*; D006736:Horses; D007660:Ketoprofen / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008070:Lipopolysaccharides; D008297:Male; D013237:Stereoisomerism; D013582:Synovial Fluid / Q000378:metabolism*; D013585:Synovitis / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D007660:Ketoprofen