title: Conformation of the glycosidic linkage in a disaccharide investigated by double-quantum solid-state NMR.
abstract: Double-quantum heteronuclear local field NMR is performed on a sample of a 13C2-labeled disaccharide, in which the two 13C spins are located on opposite sides of the glycosidic linkage. The evolution of the double-quantum coherences is found to be consistent with the solid-state conformation of the molecule, as previously determined by X-ray diffraction. The dependence of the double-quantum evolution on the glycosidic torsional angles is examined by using a graphical molecular manipulation program interfaced to a numerical spin simulation module.
authors.affiliation: Physical Chemistry Division, Stockholm University, Stockholm, S-10691, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Ravindranathan
authors.forename: T
authors.initials: T
authors.lastname: Karlsson
authors.forename: K
authors.initials: K
authors.lastname: Lycknert
authors.forename: G
authors.initials: G
authors.lastname: Widmalm
authors.forename: M H
authors.initials: MH
authors.lastname: Levitt
mesh_terms: D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D003198:Computer Simulation; D004187:Disaccharides / Q000737:chemistry*; D006027:Glycosides / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data
chemical_list: D004187:Disaccharides; D006027:Glycosides