[Oxidative stress and human disease. Current knowledge and perspectives for prevention].
DYNAMIC BALANCE: The antibiotic status of the human organism results from the dynamic balance between the antioxidant system and the production of reactive oxygen species. Oxidative stress occurs when this balance shifts in favor of pro-oxidants as can occur in several disease situations. ROS: Part of the oxygen used by cells is transformed into toxic metabolites, reactive oxygen species (ROS), which can be the cause or consequence of tissue and molecular disorders. Some of the most prominent diseases linked with oxidative stress include atherosclerosis, cancer, allergy, neurodegenerative diseases, Parkinson's disease. PERSPECTIVES FOR PREVENTION: Actions designed to prevent the environmental cause, such as eviction of a exposure to toxins or a change in eating habits, can be an effective means of reducing the lesions induced. Study of total antioxidant potential could be quite useful for detecting and monitoring environmental damage and for clinical follow-up. It could also help in determining, for each individual, the negative or positive development of a therapy on the anti-free radical action. Treatments must be personalized according to the tested response.
Lehucher-Michel
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Centre de Consultations de Pathologie professionnelle, Service de Médecine du Travail et des Risques professionnels, Hôpitaux de la Timone, 7, boulevard Jean Moulin, F 13385 Marseille.
Lesgards
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JF
Delubac
O
O
Stocker
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P
Durand
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Prost
M
M
D001161:Arteriosclerosis / Q000209:etiology* / Q000517:prevention & control; D002908:Chronic Disease; D004032:Diet; D004781:Environmental Exposure; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000517:prevention & control; D009422:Nervous System Diseases / Q000209:etiology* / Q000517:prevention & control; D018384:Oxidative Stress; D011634:Public Health; D017382:Reactive Oxygen Species; D015262:Xenobiotics / Q000009:adverse effects
D017382:Reactive Oxygen Species; D015262:Xenobiotics