title: The role of phosphoinositides in membrane transport.
abstract: Phosphoinositides serve as intrinsic membrane signals that regulate intracellular membrane trafficking. Recently, phosphoinositides have been found to direct the localization and activity of effector proteins containing consensus sequence motifs such as FYVE, PH and ENTH domains. In addition, recent results show that regulated synthesis and turnover of phosphoinositides by membrane-associated phosphoinoside kinases and phosphatases spatially restrict the location of effectors critical for cellular transport processes, such as clathrin-mediated endocytosis, autophagy, phagocytosis, macropinocytosis and biosynthetic trafficking.
authors.affiliation: Department of Biochemistry, Institute for Cancer Research, the Norwegian Radium Hospital, Montebello, N-0310, Oslo, Norway.
authors.forename: A
authors.initials: A
authors.lastname: Simonsen
authors.forename: A E
authors.initials: AE
authors.lastname: Wurmser
authors.forename: S D
authors.initials: SD
authors.lastname: Emr
authors.forename: H
authors.initials: H
authors.lastname: Stenmark
mesh_terms: D000818:Animals; D001343:Autophagy; D004705:Endocytosis; D011992:Endosomes / Q000378:metabolism; D008954:Models, Biological; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000502:physiology; D018129:Phosphatidylinositol Phosphates / Q000502:physiology; D010716:Phosphatidylinositols / Q000502:physiology*; D014176:Protein Biosynthesis; D021381:Protein Transport
chemical_list: D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; C055525:phosphatidylinositol 3-phosphate; C037178:phosphatidylinositol 4-phosphate