Cerebral perfusion during anesthesia with fentanyl, isoflurane, or pentobarbital in normal rats studied by arterial spin-labeled MRI.
The influence of anesthetic agents on cerebral blood flow (CBF) was tested in normal rats. CBF is quantified with arterial spin-labeled MRI in rats anesthetized with either an opiate (fentanyl), a potent inhalation anesthetic agent (isoflurane), or a barbiturate (pentobarbital) using doses commonly employed in experimental paradigms. CBF values were found to be about 2.5-3 times lower in most regions analyzed during anesthesia with either fentanyl (with N(2)O/O(2)) or pentobarbital vs. isoflurane (with N(2)O/O(2)), in agreement with findings utilizing invasive measurement techniques. CBF was heterogeneous in rats anesthetized with isoflurane (with N(2)O/O(2)), but relatively homogeneous in rats anesthetized with either fentanyl (with N(2)O/O(2)) or pentobarbital, also in agreement with studies using other techniques. Magn Reson Med 46:202-206, 2001.
Hendrich
K S
KS
Pittsburgh NMR Center for Biomedical Research, Carnegie Mellon University, Pittsburgh, PA 15260, USA.
Kochanek
P M
PM
Melick
J A
JA
Schiding
J K
JK
Statler
K D
KD
Williams
D S
DS
Marion
D W
DW
Ho
C
C
D000768:Anesthesia, General; D000777:Anesthetics; D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005283:Fentanyl; D007530:Isoflurane; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D010424:Pentobarbital; D051381:Rats; D017207:Rats, Sprague-Dawley
D000777:Anesthetics; D007530:Isoflurane; D010424:Pentobarbital; D005283:Fentanyl