title: [ECLAMC: 30-year study of epidemiological surveillance of neural tube defects in Chile and Latin America].
abstract: BACKGROUND
  There is an urgent need to assess the impact, on the incidence of neural tube defects, of the recently implanted flour fortification with folic acid in Chile. The Collaborative Study of Congenital Malformations in Latin America (ECLAMC) has carried out an uninterrupted register of congenital malformations in the last thirty years.
  
  
  OBJECTIVE
  To assess the epidemiology of neural tube defects in Chile and determine the most adequate base period to evaluate the effects of Folic acid fortification.
  
  
  METHODS
  Analysis of ECLAMC database that has registered all births over 500 g from 1967.
  
  
  RESULTS
  From 1967 to 1999, there were 434.624 births in 18 hospitals in Chile and 3.586.569 births in 155 hospitals in the rest of Latin America. The rate of neural tube defects in Chile was 17.03 per 10.000, significantly higher than the rest of ECLAMC (14.88 per 10.000). The prevalence of neural tube defects has a statistically significant secular tendency to increase in the study period and is higher among stillbirths, newborns with a birth weight of less than 1500 g, women and offspring of mothers aged less than 19 years old.
  
  
  CONCLUSIONS
  The period 1982-1999 is considered the best period for reference comparisons of the effects folic acid supplementation.
authors.affiliation: Unidad de neonatología hospital Clínico Universidad de Chile, Santos Dumont 999 Independencia, Santiago-Chile.
authors.forename: J
authors.initials: J
authors.lastname: Nazer
authors.forename: J
authors.initials: J
authors.lastname: López-Camelo
authors.forename: E E
authors.initials: EE
authors.lastname: Castilla
mesh_terms: D000328:Adult; D001724:Birth Weight; D002677:Chile / Q000453:epidemiology; D016001:Confidence Intervals; D003430:Cross-Sectional Studies; D016208:Databases, Factual; D005260:Female; D006801:Humans; D015994:Incidence; D007843:Latin America / Q000453:epidemiology; D008297:Male; D008423:Maternal Age; D009436:Neural Tube Defects / Q000453:epidemiology* / Q000235:genetics; D011159:Population Surveillance; D015995:Prevalence