title: [Experimental results of the use of hyaluronic acid based materials (CV Seprafilm and CV Sepracoat) in postoperative pericardial adhesions].
abstract: Repeat cardiac surgical procedures are associated with increased technical difficulty and risk related to the presence of dense adhesions between the heart and the surrounding tissues. We examined the efficacy of a bioabsorbable membrane containing hyaluronic acid in the prevention of pericardial adhesions in 23 rabbits. After thoracotomy and pericardiotomy the animals were divided in three groups: Group 1 (9 animals) in which the epicardial surfaces were covered by Seprafilm membrane, Group 2 (9 animals) treated with both Seprafilm membrane and Sepracoat solution, and Group 3 (5 animals) as controls. The animals were reexplored at 10, 30 and 60 days: no intrapericardial adhesions were found in all the animals of Group 2. In 4 animals (44%) of Group 1 localized post-operative adhesions were detected, in absence of epicardial hyperplasia; in contrast, dense and diffuse adhesions were present in all the control animals. The use of the bioabsorbable membrane Seprafilm significantly reduces adhesion formation even if better results are possible with the previous intrapericardial administration of Sepracoat solution. Application of these biocompatible products could reduce the technical difficulty and risk of repeat surgical procedures.
authors.affiliation: Cattedra e Divisione di Cardiochirurgia, Università degli Studi, Parma.
authors.forename: L
authors.initials: L
authors.lastname: Ballore
authors.forename: F
authors.initials: F
authors.lastname: Orrù
authors.forename: F
authors.initials: F
authors.lastname: Nicolini
authors.forename: S A
authors.initials: SA
authors.lastname: Contini
authors.forename: G
authors.initials: G
authors.lastname: Galletti
authors.forename: T
authors.initials: T
authors.lastname: Gherli
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D009202:Cardiomyopathies / Q000517:prevention & control; D005260:Female; D006820:Hyaluronic Acid; D008297:Male; D008567:Membranes, Artificial; D010496:Pericardium; D011817:Rabbits; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D001672:Biocompatible Materials; D008567:Membranes, Artificial; C118198:Seprafilm; D006820:Hyaluronic Acid