Effects of forebrain microinjection of cholecystokinin on dopamine cell firing rate.
In anesthetized rats, midbrain dopamine (DA) neuronal firing rate was differentially sensitive to focal brain microinjection of cholecystokinin peptides (CCK-4 and CCK-8) and N-methyl-D-aspartate (NMDA) into nucleus accumbens, amygdala and prefrontal cortex. Whereas changes in DA neuronal firing rate were frequently observed in response to intra-amygdalar microinjection of CCK peptides, NMDA was most effective in eliciting changes in DA neuronal activity following intra-accumbal microinjection. Thus, stimulation of amygdalar CCK receptors and accumbal excitatory amino acid receptors may participate in the afferent regulation of midbrain DA neuronal function.
Hamilton
M E
ME
Department of Pharmacology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.
Weddige
F K
FK
Freeman
A S
AS
D000596:Amino Acids / Q000737:chemistry; D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects; D002766:Cholecystokinin / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D004594:Electrophysiology; D020128:Inhibitory Concentration 50; D008297:Male; D008636:Mesencephalon / Q000187:drug effects; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018697:Nootropic Agents / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000187:drug effects; D010671:Phenylurea Compounds / Q000494:pharmacology; D016548:Prosencephalon / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012844:Sincalide / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
C090019:8-sulfocholecystokinin octapeptide; D000596:Amino Acids; D001570:Benzodiazepinones; D018697:Nootropic Agents; D010671:Phenylurea Compounds; C090649:L 740093; D016202:N-Methylaspartate; D002766:Cholecystokinin; D012844:Sincalide; D004298:Dopamine