Eosinophilic pustular eruption associated with transdermal fentanyl.
A 70-year-old man developed a widespread eruption of sterile pustules on normal skin, mainly on the trunk, face and base of the limbs, 2 days after application of a fentanyl-transdermal therapeutic system (fentanyl-TTS) patch. The eruption was not accompanied by fever. The main histopathological finding was an intraepidermal pustule filled almost exclusively with eosinophils. Suspension of the fentanyl-TTS led to rapid and definitive spontaneous regression of the pustules in about 10 days. A similar pustular reaction related temporally to fentanyl-TTS administration had appeared several weeks before the current eruption.
Mancuso
G
G
Department of Dermatology of Municipal Hospital of Lugo, Ravenna, Italy.
Berdondini
R M
RM
Passarini
B
B
D000279:Administration, Cutaneous; D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000009:adverse effects*; D004802:Eosinophilia / Q000139:chemically induced* / Q000473:pathology; D005283:Fentanyl / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology
D000701:Analgesics, Opioid; D005283:Fentanyl