The impact of inflammation on bronchial neuronal networks.
It is well-recognized that the activities of airway neuronal systems can be modulated by various agonist molecules. This brief review examines some of the evidence that inflammation and some of the mediators relevant to the expression of inflammatory processes can also significantly alter the function and activities of airway nerves. The concept of neuronal plasticity and phenotype switching induced by inflammation is also examined, with particular emphasis on sensory airway nerves.
Goldie
R G
RG
Department of Pharmacology, The University of Western Australia, Western Australian Institute for Medical Research, Nedlands, Perth, WA, 6907, Australia. rgoldie@receptor.pharm.uwa.edu.au
Rigby
P J
PJ
Fernandes
L B
LB
Henry
P J
PJ
D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D007249:Inflammation; D009473:Neuronal Plasticity / Q000502:physiology; D018377:Neurotransmitter Agents / Q000494:pharmacology; D010275:Parasympathetic Nervous System / Q000502:physiology*; D010641:Phenotype; D012137:Respiratory System / Q000276:immunology / Q000294:innervation* / Q000473:pathology
D018377:Neurotransmitter Agents