title: Pharmacokinetics of alizapride in children receiving chemotherapy for solid tumour.
abstract: The purpose of the present study was to determine the pharmacokinetics of alizapride to optimize its use in children aged 1 month to 15 years old who were receiving chemotherapy. Seventeen children were given a single 4 mg/kg alizapride infusion prior to the administration of cytostatic drugs. Blood and urine samples were collected within 10 h after onset of the infusion. Kinetic parameters were calculated and showed a decrease in plasma clearance expressed per unit of body weight with age. The current data suggest that dosage expressed per unit of body weight should be higher in children than in adults and higher in infants than in children.
authors.affiliation: Pharmacologie Périnatale et Pédiatrique, Hôpital Saint-Vincent de Paul, Université René Descartes Paris V, France. elisabeth.rey@svp.ap-hop-paris.fr
authors.forename: E
authors.initials: E
authors.lastname: Rey
authors.forename: E
authors.initials: E
authors.lastname: Stettler
authors.forename: P
authors.initials: P
authors.lastname: D'athis
authors.forename: G
authors.initials: G
authors.lastname: Pons
mesh_terms: D000293:Adolescent; D000932:Antiemetics / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D019540:Area Under Curve; D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism; D011759:Pyrrolidines / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D011759:Pyrrolidines; C033968:alizapride