The death factors: a combinatorial analysis.
This paper presents theoretical and computational tools to understand how a small group of proteins, the death factors, are involved in widely different behavior of the cell. Experiments were done using a virtual laboratory that can simulate cellular response to different external stimuli. WARNING: It is not certain which of the theoretical protein clusters described here really occur in nature. In addition, the rules of cluster assembly are combinatorial, and thus an oversimplification to describe the real situation.
Bergeron
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LACIM, Université du Québec à Montréal, C.P. 8888 Succ. Centre-Ville, Montréal, Québec, Canada, H3C 3P8. anne@lacim.uqam.ca
Geanta
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P
Bergeron
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D000818:Animals; D017209:Apoptosis / Q000502:physiology; D020650:Combinatorial Chemistry Techniques; D003198:Computer Simulation; D006801:Humans; D008954:Models, Biological; D017434:Protein Structure, Tertiary; D011506:Proteins / Q000737:chemistry* / Q000502:physiology*; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry / Q000502:physiology; D015398:Signal Transduction; D014584:User-Computer Interface
D011506:Proteins; D018124:Receptors, Tumor Necrosis Factor