title: Hippocampal sclerosis following brief generalized seizures in adulthood.
abstract: This report describes a patient who had a first generalized tonic clonic seizure (GTCS) at the age of 18 years. The initial MRI scan was normal on visual and quantitative examination. After a further six GTCS, a second MRI scan showed reduced hippocampal volume and increased hippocampal T2 signal, which was confirmed in a third scan. Therefore, hippocampal sclerosis may be acquired in adulthood after brief GTCS.
authors.affiliation: Brain Research Institute, Austin and Repatriation Medical Center, and University of Melbourne, Australia.
authors.forename: R S
authors.initials: RS
authors.lastname: Briellmann
authors.forename: M R
authors.initials: MR
authors.lastname: Newton
authors.forename: R M
authors.initials: RM
authors.lastname: Wellard
authors.forename: G D
authors.initials: GD
authors.lastname: Jackson
mesh_terms: D000293:Adolescent; D004830:Epilepsy, Tonic-Clonic / Q000473:pathology*; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D012598:Sclerosis