title: Once-daily treatment of patients with hypertension: a placebo-controlled study of amlodipine and benazepril vs amlodipine or benazepril alone.
abstract: OBJECTIVE
  To compare the efficacy, tolerability, and safety of once-daily therapy with amlodipine 5 mg/benazepril 10 mg vs amlodipine 5 mg, benazepril 10 mg, and placebo.
  
  
  METHODS
  Randomised, double-blind, placebo-controlled, parallel-group, multicentre trial.
  
  
  METHODS
  Twenty-two clinical centres, including private practice groups and academic research clinics.
  
  
  METHODS
  A total of 530 patients between 21 and 80 years of age with essential hypertension were screened for the study, and 454 were randomised to treatment with amlodipine 5 mg/benazepril 10 mg, amlodipine 5 mg, benazepril 10 mg, or placebo for 8 weeks.
  
  
  RESULTS
  Amlodipine 5 mg/benazepril 10 mg produced greater reductions from baseline in sitting diastolic blood pressure than amlodipine 5 mg (P < 0.03), benazepril 10 mg (P < 0.001), and placebo (P < 0.001). The response rate in the amlodipine 5-mg/benazepril 10-mg treatment group (66.4%) was better than that observed in the amlodipine 5-mg (50.0% P < 0.02), benazepril 10-mg (38.3% P < 0.001), and placebo (24.4% P < 0.001) groups. There was no significant difference in heart rate among the four groups. The incidence of oedema in the amlodipine 5-mg/benazepril 10-mg (1.7%) group was somewhat less than that in the amlodipine 5-mg (4.5%) group.
  
  
  CONCLUSIONS
  Therapy with amlodipine 5 mg/benazepril 10 mg was well tolerated and was superior to amlodipine 5 mg, benazepril 10 mg, and placebo in reducing sitting diastolic blood pressure in patients with essential hypertension.
authors.affiliation: The Methodist Hospital, Houston, TX, USA.
authors.forename: J
authors.initials: J
authors.lastname: Pool
authors.forename: P
authors.initials: P
authors.lastname: Kaihlanen
authors.forename: G
authors.initials: G
authors.lastname: Lewis
authors.forename: D
authors.initials: D
authors.lastname: Ginsberg
authors.forename: S
authors.initials: S
authors.lastname: Oparil
authors.forename: R
authors.initials: R
authors.lastname: Glazer
authors.forename: F H
authors.initials: FH
authors.lastname: Messerli
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017311:Amlodipine / Q000008:administration & dosage*; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D001552:Benzazepines / Q000008:administration & dosage*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome
chemical_list: D000959:Antihypertensive Agents; D001552:Benzazepines; D017311:Amlodipine; C044946:benazepril