title: [Meningeal carcinomatosis in gastric cancer].
abstract: Meningeal carcinomatosis is an uncommon complication in patients with advanced gastric cancer. We report four cases of meningeal carcinomatosis occurring 18 months (mean) after the diagnosis. The presenting manifestations were headache, visual troubles and seizure. Cytological cerebrospinal fluid (CSF) examination was the most useful diagnostic tool for leptomeningeal carcinomatosis, considering the normality of brain CT scan and MRI in our patients. Intrathecal methotrexate administration achieved a rapid improvement in neurological symptoms in all cases, but for a short 2-3 months duration. We conclude that survival improvement in advanced gastric cancer, due to chemotherapy, may allow emergence of unusual complications such as carcinomatous meningitis. This diagnosis should be evoked in the presence of unexplained neurologic symptoms and confirmed by CSF examination in order to propose a treatment and to delay serious neurologic disability and prolong survival.
authors.affiliation: Service de Médecine Interne - Oncologie, Hôpital Saint-Antoine, Paris, France.
authors.forename: L
authors.initials: L
authors.lastname: Vedrine
authors.forename: P
authors.initials: P
authors.lastname: Artru
authors.forename: C
authors.initials: C
authors.lastname: Tournigand
authors.forename: C
authors.initials: C
authors.lastname: Louvet
authors.forename: A
authors.initials: A
authors.lastname: De Gramont
authors.forename: M
authors.initials: M
authors.lastname: Krulik
mesh_terms: D000230:Adenocarcinoma / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000556:secondary*; D000328:Adult; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000175:diagnosis / Q000556:secondary*; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000473:pathology*; D014057:Tomography, X-Ray Computed