[Analysis of psoriasis susceptibility regions in the Spanish population: evidence of a major gene involved in psoriasis in the 6p21 region].
BACKGROUND
Identification of the susceptibility regions to psoriasis in Spanish population. Analysis of the chromosomal regions 6p, 17q, 4q and 1cen-q21.


METHODS
Analysis of 27 Spanish families with psoriasis. Parametric and non-parametric linkage analysis with 22 polymorphic microsatellite markers in the candidate regions.


RESULTS
Evidence of linkage (p < 0,05) using non-parametric methods in chromosome 6p. Absence of linkage in 17q, 4q and 1cen-q21 regions.


CONCLUSIONS
We present the evidence of a major gene in 6p21.3 involved in psoriasis in Spanish population.
de Cid
R
R
Centre de Genètica Mèdica i Molecular, Institut de Recerca Oncològica, L'Hospitalet de Llobregat, Barcelona.
Volpini
V
V
Almasy
L
L
Otero
D
D
Estivil
X
X
Lázaro
C
C
D000328:Adult; D015984:Causality; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D011565:Psoriasis / Q000235:genetics*; D013030:Spain