title: Bilateral fronto-occipital polymicrogyria and epilepsy.
abstract: We present a clinico-pathological case report in which both cortical dysplasia and epilepsy coexisted: a 30 year old male who was dead on arrival at hospital. One and a half hours earlier he had developed complex partial status with peri-oral cyanosis. At post mortem examination his brain showed bilateral occipital frontal polymicrogyria with unlayered neuronal migration disorder; in other parts there were fourth layer migration disorders. The white matter exhibited multicystic encephalopathy. In the heart there was chronic interstitial and perivascular fibrosis, although he died of a cardiac arrest. Bilateral frontal-occipital polymicrogyria is highly epileptogenic. This was a sporadic case and we cannot define a clear aetiology. There was a pathological cardiac condition without previous vascular risk factors which might be related to repetition of seizures and possibly to his sudden death during status epilepticus.
authors.affiliation: Unit of Neurology, H. Alvarez Buylla, Mieres, Asturias, Spain. rribacobam@meditex.es
authors.forename: R
authors.initials: R
authors.lastname: Ribacoba Montero
authors.forename: C
authors.initials: C
authors.lastname: Garcia Pravia
authors.forename: A
authors.initials: A
authors.lastname: Astudillo
authors.forename: J
authors.initials: J
authors.lastname: Salas Puig
mesh_terms: D000328:Adult; D002465:Cell Movement / Q000502:physiology; D004827:Epilepsy / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D017809:Fatal Outcome; D005625:Frontal Lobe / Q000002:abnormalities*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D008297:Male; D009474:Neurons / Q000473:pathology; D009778:Occipital Lobe / Q000002:abnormalities*