Metachronous primary carcinomas of the lung in an HIV-infected patient.
Studies have suggested that human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) patients have an increased risk of developing primary lung cancer, with a poor prognosis. We report a 59-year-old HIV-seropositive man who developed two metachronous primary bronchogenic carcinomas with different histologic features. The initial tumor was cured after early diagnosis and resection, with subsequent development of a contralateral tumor 6 years later. The case emphasizes that early diagnosis and treatment of lung cancer in HIV/AIDS patients should be sought as they may improve their short-term prognosis. However, because of their immunocompromised state, extended survival is still limited by a higher likelihood of developing subsequent malignancies.
Aviram
G
G
Department of Radiology, Jackson Memorial Hospital, University of Miami School of Medicine, Miami, Florida 33136-1094, USA.
Fishman
J E
JE
Schwartz
D S
DS
D002283:Carcinoma, Bronchogenic / Q000000981:diagnostic imaging*; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging / Q000473:pathology*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging / Q000473:pathology*; D011379:Prognosis; D011859:Radiography