title: (-)3-[4-[2-(Phenoxazin-10-yl)ethoxy]phenyl]-2-ethoxypropanoic acid [(-)DRF 2725]: a dual PPAR agonist with potent antihyperglycemic and lipid modulating activity.
abstract: (-)DRF 2725 (6) is a phenoxazine analogue of phenyl propanoic acid. Compound 6 showed interesting dual activation of PPAR alpha and PPAR gamma. In insulin resistant db/db mice, 6 showed better reduction of plasma glucose and triglyceride levels as compared to rosiglitazone. Compound 6 has also shown good oral bioavailability and impressive pharmacokinetic characteristics. Our study indicates that 6 has great potential as a drug for diabetes and dyslipidemia.
authors.affiliation: Discovery Synthesis and Discovery Biology, Dr. Reddy's Research Foundation, 7-1-27, Ameerpet, Hyderabad 500 016, India.
authors.forename: B B
authors.initials: BB
authors.lastname: Lohray
authors.forename: V B
authors.initials: VB
authors.lastname: Lohray
authors.forename: A C
authors.initials: AC
authors.lastname: Bajji
authors.forename: S
authors.initials: S
authors.lastname: Kalchar
authors.forename: R R
authors.initials: RR
authors.lastname: Poondra
authors.forename: S
authors.initials: S
authors.lastname: Padakanti
authors.forename: R
authors.initials: R
authors.lastname: Chakrabarti
authors.forename: R K
authors.initials: RK
authors.lastname: Vikramadithyan
authors.forename: P
authors.initials: P
authors.lastname: Misra
authors.forename: S
authors.initials: S
authors.lastname: Juluri
authors.forename: N V
authors.initials: NV
authors.lastname: Mamidi
authors.forename: R
authors.initials: R
authors.lastname: Rajagopalan
mesh_terms: D000818:Animals; D001682:Biological Availability; D001786:Blood Glucose / Q000032:analysis*; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy; D006949:Hyperlipidemias / Q000150:complications / Q000188:drug therapy; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D007333:Insulin Resistance; D051379:Mice; D010078:Oxazines / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D010666:Phenylpropionates / Q000138:chemical synthesis* / Q000493:pharmacokinetics / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018160:Receptors, Cytoplasmic and Nuclear / Q000819:agonists*; D013237:Stereoisomerism; D014157:Transcription Factors / Q000819:agonists*; D014280:Triglycerides / Q000097:blood*
chemical_list: D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010078:Oxazines; D010666:Phenylpropionates; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors; D014280:Triglycerides; C432703:ragaglitazar