Voluntary physical activity prevents stress-induced behavioral depression and anti-KLH antibody suppression.
The current study addressed whether physical activity can buffer stress-induced "behavioral depression" and immunosuppression. Adult, male Sprague-Dawley rats were housed with either a mobile (physically active) or immobile (sedentary) running wheel and exposed to either stress (inescapable tail shock) or no stress (home cage control). Voluntary wheel running began 4 wk before stressor exposure. Immediately before stress, all rats were administered an intraperitoneal injection of keyhole limpet hemocyanin (KLH; 200 microg), and anti-KLH Ig was measured weekly for 4 wk using ELISA. Prior physical activity reduced the stress-induced behavioral depression and prevented the stress-induced suppression of anti-KLH IgM and IgG(2a) antibodies. Anti-KLH IgG(1) was stress insensitive. These data suggest that physical activity can buffer the negative impact of stress on behavior and acquired immune function.
Moraska
A
A
University of Colorado at Boulder, Department of Kinesiology and Applied Physiology, Boulder, CO 80309, USA.
Fleshner
M
M
D000276:Adjuvants, Immunologic; D000818:Animals; D001835:Body Weight; D003863:Depression / Q000517:prevention & control*; D004558:Electric Stimulation; D006433:Hemocyanins / Q000008:administration & dosage / Q000276:immunology; D007108:Immune Tolerance; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013315:Stress, Psychological
D000276:Adjuvants, Immunologic; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin