Lack of association between apolipoprotein E genoype and ischaemic stroke in a Scottish population.
BACKGROUND
Apolipoprotein E epsilon4 allele has been associated with increased risk of coronary heart disease, and is also a major genetic susceptibility locus for Alzheimer's disease. Some studies have shown an association between apoE genotype and ischaemic stroke or outcome following stroke, while other studies have failed to do so. Materials and methods Using PCR and the Taqman fluorescence system to detect polymorphisms we examined apoE genotype in 266 ischaemic stroke cases and in a control population.


RESULTS
We found no association between apoeE epsilon 4 allele distribution and ischaemic stroke, or with outcome following stroke as measured using the Rankin score. Conclusion This study disagrees with a recent meta-analysis, and suggests that further studies are required to clarify the exact relationship between apoE genotype and ischaemic stroke.
MacLeod
M J
MJ
University of Aberdeen, Aberdeen, UK. mmd275@abdn.ac.uk
De Lange
R P
RP
Breen
G
G
Meiklejohn
D
D
Lemmon
H
H
Clair
D S
DS
D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D002545:Brain Ischemia / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012606:Scotland / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics
D001057:Apolipoproteins E