title: Influences of systemic diseases on periodontitis in children and adolescents.
abstract: Systemic diseases affecting the host response as primary immunodeficiencies or secondary defects caused by lack of nutrients or changes in the local tissues are very often accompanied by early-onset prepubertal periodontitis. Local treatment in combination with systemic antibiotics may in milder forms improve the situation, but in many cases the success is questionable and premature loss of teeth occurs. Since the genetic basis of many of the diseases has been identified, future developments permit the correction of at least some of these defects by gene therapy.
authors.affiliation: Department of Periodontology, Zentrum für Zahn-, Mund und Kieferheilkunde, Universität Giessen, Giessen, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Meyle
authors.forename: J R
authors.initials: JR
authors.lastname: Gonzáles
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000503:physiopathology; D000293:Adolescent; D010520:Aggressive Periodontitis / Q000209:etiology / Q000503:physiopathology; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002609:Chediak-Higashi Syndrome / Q000150:complications / Q000503:physiopathology; D002648:Child; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000503:physiopathology; D004194:Disease; D004198:Disease Susceptibility; D004314:Down Syndrome / Q000150:complications / Q000503:physiopathology; D004535:Ehlers-Danlos Syndrome / Q000150:complications / Q000503:physiopathology; D015316:Genetic Therapy; D015614:Histiocytosis / Q000150:complications / Q000503:physiopathology; D006801:Humans; D007014:Hypophosphatasia / Q000150:complications / Q000503:physiopathology; D018370:Leukocyte-Adhesion Deficiency Syndrome / Q000150:complications / Q000503:physiopathology; D009503:Neutropenia / Q000150:complications / Q000503:physiopathology; D009748:Nutrition Disorders / Q000150:complications / Q000503:physiopathology; D010214:Papillon-Lefevre Disease / Q000150:complications / Q000503:physiopathology; D010518:Periodontitis / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000900:Anti-Bacterial Agents