Progressive outer retinal necrosis syndrome: successful treatment with a new combination of antiviral drugs.
OBJECTIVE
To describe a case of progressive outer retinal necrosis syndrome, successfully treated with a new combination of antiviral drugs.


METHODS
The patient was treated with a combined therapy of antiviral drugs that includes: intravenous acyclovir 10 mg/kg, three intravitreal injections of foscarnet (1200 microg) and a ganciclovir implant in the right eye.


RESULTS
The progressive outer retinal necrosis appeared to response dramatically with the combination of antiviral agents used over a period of 2 weeks with a final visual acuity of 20/80 at 3 months of follow up.


CONCLUSIONS
Intravitreal foscarnet combined with i.v. acyclovir and ganciclovir implant may represent an effective alternative treatment for PORN.
Roig-Melo
E A
EA
Department of Ophthalmology, Hanna Retina Research Center, Storm Eye Institute, Medical University of South Carolina, Charleston 29425-2236, USA.
Macky
T A
TA
Heredia-Elizondo
M L
ML
Alfaro
D V
DV
D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D000212:Acyclovir / Q000008:administration & dosage; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use*; D018450:Disease Progression; D004343:Drug Implants; D004359:Drug Therapy, Combination; D015828:Eye Infections, Viral / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D017245:Foscarnet / Q000008:administration & dosage; D015774:Ganciclovir / Q000008:administration & dosage; D006561:Herpes Simplex / Q000188:drug therapy* / Q000473:pathology / Q000821:virology; D006801:Humans; D008297:Male; D015882:Retinal Necrosis Syndrome, Acute / Q000188:drug therapy* / Q000473:pathology / Q000821:virology
D000998:Antiviral Agents; D004343:Drug Implants; D017245:Foscarnet; D015774:Ganciclovir; D000212:Acyclovir