title: Management of heparin allergy in pregnancy.
abstract: Thromboembolic disease during pregnancy has traditionally been treated with heparin. If heparin cannot be used, then treatment options remain limited. Despite the recent availability of new anticoagulation agents, data relating to their use during pregnancy is lacking. Hirudin, a relatively new anti-thrombotic agent, through animal models has been shown to have a very low transplacental transfer, thus making it a candidate drug to be used during pregnancy in case of heparin allergy. This report describes a case of heparin allergy in a pregnant patient with recurrent DVT that was successfully managed with hirudin and coumadin.
authors.affiliation: Department of Hematology-Oncology, Westchester Medical Center, Department of Internal Medicine, Westchester Medical Center, Valhalla, New York 10595, USA. AAIJ@aol.com
authors.forename: A
authors.initials: A
authors.lastname: Aijaz
authors.forename: J
authors.initials: J
authors.lastname: Nelson
authors.forename: N
authors.initials: N
authors.lastname: Naseer
mesh_terms: D000328:Adult; D000075202:Contraindications; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006493:Heparin / Q000009:adverse effects* / Q000276:immunology; D006629:Hirudins / Q000008:administration & dosage; D006801:Humans; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D020246:Venous Thrombosis / Q000188:drug therapy / Q000517:prevention & control; D014859:Warfarin / Q000008:administration & dosage
chemical_list: D006629:Hirudins; D014859:Warfarin; D006493:Heparin