title: Acute renal insufficiency and renal replacement therapy after pediatric cardiopulmonary bypass surgery.
abstract: The aim of the study was to investigate renal function and renal replacement therapy after cardiopulmonary bypass surgery in children. Patient characteristics (sex, age, diagnosis), operation type, and death were listed. The study was performed retrospectively using serum creatinine level before, and peak values after, cardiopulmonary bypass surgery for assessment of renal function. Of the children on renal replacement therapy, indication, efficacy, and complications were recorded. In a 5-year period, 1075 children had cardiopulmonary bypass surgery at the Department of Cardiothoracic Surgery at Leiden University Medical Center and Academic Medical Center of Amsterdam. One-hundred eighty (17%) patients developed acute renal insufficiency. Twenty-five (2.3%) patients required renal replacement therapy. Peritoneal dialysis is a safe and effective treatment for children after cardiopulmonary bypass surgery. However, 15 (60%) of 25 children on renal replacement therapy died of nonrenal causes. In 9 out of 10 surviving children, renal function was normal at time of discharge from hospital. Acute renal insufficiency is a frequent complication after open-heart surgery, although renal replacement therapy was infrequently necessary. Peritoneal dialysis is a safe and effective therapeutic measure for children after cardiac bypass surgery.
authors.affiliation: Department of Pediatrics, Leiden University Medical Center, Postbus 9600, 2300 RC Leiden, The Netherlands.
authors.forename: J E
authors.initials: JE
authors.lastname: Kist-van Holthe tot Echten
authors.forename: C A
authors.initials: CA
authors.lastname: Goedvolk
authors.forename: M B
authors.initials: MB
authors.lastname: Doornaar
authors.forename: M M
authors.initials: MM
authors.lastname: van der Vorst
authors.forename: J M
authors.initials: JM
authors.lastname: Bosman-Vermeeren
authors.forename: R
authors.initials: R
authors.lastname: Brand
authors.forename: A J
authors.initials: AJ
authors.lastname: van der Heijden
authors.forename: P H
authors.initials: PH
authors.lastname: Schoof
authors.forename: M G
authors.initials: MG
authors.lastname: Hazekamp
mesh_terms: D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D016015:Logistic Models; D008297:Male; D010530:Peritoneal Dialysis / Q000379:methods; D017582:Renal Replacement Therapy / Q000379:methods*; D012189:Retrospective Studies