Uptake of tritiated D-mannoheptulose by liver, pancreatic exocrine and endocrine cells.
Tritiated D-mannoheptulose, a ketoheptose known to inhibit D-glucose metabolism in hepatocytes and pancreatic islets, but not so in pancreatic acinar cells, was injected intravenously in streptozotocin-induced diabetic mice transplanted under the kidney capsule with islets from control mice of the same strain. One hour after the injection of the tritiated heptose, the radioactive content was 5-8 times higher in the liver and transplanted islets than in the pancreatic gland. It is proposed that suitably radiolabelled D-mannoheptulose could be used to label preferentially the endocrine moiety of the pancreatic gland, e.g., in the perspective of its non-invasive imaging.
Crenier
L
L
Laboratory of Experimental Medicine, Brussels Free University, Brussels, Belgium.
Courtois
P
P
Malaisse
W J
WJ
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D004702:Endocrine Glands / Q000378:metabolism; D005088:Exocrine Glands / Q000378:metabolism; D005260:Female; D007515:Islets of Langerhans / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008356:Mannoheptulose / Q000009:adverse effects / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010179:Pancreas / Q000378:metabolism*; D013311:Streptozocin; D017186:Titrimetry
D013311:Streptozocin; D008356:Mannoheptulose