Birth weight and parental PGM1 alleles.
A deviation of the maternal-neonatal joint phosphoglucomutase locus 1 (PGM1) distribution from Hardy-Weinberg expectation has been reported. It was suggested that selection on PGM1 during intrauterine life might account for these deviations and that maternal and paternal PGM1 alleles might have different associations with intrauterine survival. This study considered possible associations between the joint mother-newborn PGM1 genotype and intrauterine growth. There was a significant association between birth weight percentile class and mother-newborn PGM1 genotype in infant females. Also, the paternal PGM1*2 allele was associated negatively with macrosomia, and this effect was significant only in female infants.
Gloria-Bottini
F
F
Department of Biopathology and Imaging Diagnostics, University of Rome Tor Vergata, Italy.
Lucarini
N
N
La Torre
M
M
Lucarelli
P
P
Bottini
E
E
D000483:Alleles; D001724:Birth Weight / Q000235:genetics*; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D005320:Fetal Macrosomia / Q000201:enzymology / Q000453:epidemiology / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics*; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D007558:Italy / Q000453:epidemiology; D016014:Linear Models; D008297:Male; D008957:Models, Genetic; D010290:Parents; D010733:Phosphoglucomutase / Q000235:genetics*; D010750:Phosphoproteins / Q000235:genetics*; D011110:Polymorphism, Genetic / Q000235:genetics*; D012641:Selection, Genetic; D012727:Sex Characteristics
D010750:Phosphoproteins; C488050:PGM1 protein, human; D010733:Phosphoglucomutase