Effect of centrally administered prolactin on gastric and duodenal ulcers in rats.
The effect of centrally administered prolactin on gastric acid secretion and experimentally-induced gastric and duodenal ulcers was studied. The acute gastric ulcer models used were pylorus ligation, indomethacin-induced and ethanol-induced gastric ulcers. Chronic gastric ulcers were induced using acetic acid and duodenal ulcers by cysteamine hydrochloride. In pylorus ligated rats, prolactin (1 microg/kg icv) produced 45% increase in gastric content volume, significant increase in free acidity (P < 0.001), total acidity (P < 0.001) and ulcer index (P < 0.001). It did not show any significant effect on ethanol-induced and indomethacin-induced gastric ulcers. Prolactin increased the ulcer index (P < 0.001) and ulcer score (P < 0.05) in acetic acid-induced chronic gastric ulcers. It also increased ulcer area (P < 0.05) in cysteamine-induced duodenal ulcers. Therefore, the proulcerogenic activity of prolactin was due to its gastric hypersecretory effect.
Asad
M
M
Jawaharlal Institute of Post-graduate Medical Education & Research, Pondicherry-605 006, India.
Shewade
D G
DG
Koumaravelou
K
K
Abraham
B K
BK
Vasu
S
S
Ramaswamy
S
S
D019342:Acetic Acid; D000818:Animals; D002908:Chronic Disease; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000503:physiopathology; D000431:Ethanol; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D007213:Indomethacin; D007276:Injections, Intraventricular; D008026:Ligation; D011388:Prolactin / Q000097:blood / Q000494:pharmacology*; D011708:Pylorus / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000503:physiopathology
D000431:Ethanol; D003543:Cysteamine; D011388:Prolactin; D019342:Acetic Acid; D007213:Indomethacin