Treatment with atypical antipsychotics: new indications and new populations.
Atypical antipsychotics have revolutionized the treatment of schizophrenia, becoming the treatment of choice for patients not only during their first episode, but also throughout their life course. Of note, as of 1999 more than 70% of prescriptions for these drugs are being prescribed for conditions other than schizophrenia, such as bipolar disorder and geriatric agitation. While there have been very few controlled trials that have established the efficacy of the atypical antipsychotics for these "off-label" uses, there have been a large number of open trials and case reports. The few controlled trials suggest that the atypical antipsychotics may be useful for affective disorders (both mania and depression), geriatric conditions such as senile dementia and aggression, as well as a variety of other disorders. Atypical agents may be particularly helpful for elderly, child, or adolescent patients who are especially susceptible to the side effects of medications and whose risk of tardive dyskinesia is high but further controlled studies are necessary.
Glick
I D
ID
Professor of Psychiatry, Stanford University School of Medicine, 401 Quarry Road, Suite No. 2122, Stanford, CA 94305, USA. iraglick@stanford.edu
Murray
S R
SR
Vasudevan
P
P
Marder
S R
SR
Hu
R J
RJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D000374:Aggression; D014150:Antipsychotic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001569:Benzodiazepines; D002648:Child; D003987:Dibenzothiazepines / Q000494:pharmacology / Q000627:therapeutic use; D004409:Dyskinesia, Drug-Induced / Q000517:prevention & control; D005852:Geriatric Psychiatry; D006801:Humans; D008875:Middle Aged; D019964:Mood Disorders / Q000188:drug therapy*; D000077152:Olanzapine; D010890:Pirenzepine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D011356:Product Labeling; D011595:Psychomotor Agitation / Q000209:etiology*; D000069348:Quetiapine Fumarate; D012307:Risk Factors; D018967:Risperidone / Q000494:pharmacology / Q000627:therapeutic use; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents; D003987:Dibenzothiazepines; D001569:Benzodiazepines; D000069348:Quetiapine Fumarate; D010890:Pirenzepine; D018967:Risperidone; D000077152:Olanzapine