Polyamines: new cues in cellular signal transduction.
The naturally occurring polyamines putrescine, spermidine, and spermine are involved in signal transduction. This has been demonstrated by using inhibitors for polyamine biosynthesis (such as alpha-difluoromethylornithine) or adding polyamines to cultured cells. Different polyamines, preferentially activated protein kinases (tyrosine kinases and MAP kinases), stimulated the expression of nuclear protooncogenes (myc, jun, and fos).
Bachrach
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U
Department of Molecular Biology, Hebrew University-Hadassah Medical School, 91120 Jerusalem, Israel.
Wang
Y C
YC
Tabib
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A
D000818:Animals; D002455:Cell Division / Q000502:physiology; D002467:Cell Nucleus / Q000502:physiology; D002468:Cell Physiological Phenomena; D015870:Gene Expression / Q000502:physiology; D009857:Oncogenes / Q000235:genetics; D011073:Polyamines / Q000378:metabolism*; D015398:Signal Transduction / Q000502:physiology*
D011073:Polyamines