[Pancreatitis ascribed to the use of itraconazole].
A 50-year-old woman was treated intermittently with itraconazole (Trisporal) due to onychomycosis. After the initial period of 7 days and after the first 9 days of the second period she experienced abdominal complaints. In the second episode, pancreatitis was diagnosed. No known risk factors for acute pancreatitis were present. The pancreatitis may have arisen due to the use of itraconazole. As far as we know, this side effect of itraconazole or other triazole derivatives has not previously been reported in the literature. It seems to be a rare side effect, for which the pathogenesis has yet to be elucidated.
Langers
A M
AM
Rijnland Ziekenhuis, afd. Algemene Interne Geneeskunde, Postbus 4220, 2350 CC Leiderdorp.
Jonkers
G J
GJ
D000208:Acute Disease; D000935:Antifungal Agents / Q000009:adverse effects*; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000009:adverse effects*; D008875:Middle Aged; D014009:Onychomycosis / Q000188:drug therapy; D010195:Pancreatitis / Q000139:chemically induced*; D012008:Recurrence; D019233:Retreatment
D000935:Antifungal Agents; D017964:Itraconazole