title: Prevalence of factor V Leiden in Thai blood donors.
abstract: Factor V Leiden was recently found to be the most common cause of familial venous thrombosis in the European population. We have studied the prevalence of factor V Leiden by DNA analysis among 500 Thai blood donors (male 285, female 215). Their ages ranged from 18 to 60 years with a mean of 33 years and 2 months. All of them were healthy voluntary blood-donors who met the standard criteria of the American Association of Blood Banks. No history of thrombosis was found. The results revealed that factor V Leiden was not present among 1,000 chromosomes from Thai blood donors. This suggests that factor V Leiden is not the common genetic predisposing factor of venous thrombosis in the Thai population as compared to the European population.
authors.affiliation: Department of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: A
authors.initials: A
authors.lastname: Chuansumrit
authors.forename: W
authors.initials: W
authors.lastname: Jarutwachirakul
authors.forename: W
authors.initials: W
authors.lastname: Sasanakul
authors.forename: S
authors.initials: S
authors.lastname: Rurgkhum
authors.forename: P
authors.initials: P
authors.lastname: Tardtong
authors.forename: P
authors.initials: P
authors.lastname: Hathirat
mesh_terms: D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D002648:Child; D005165:Factor V / Q000235:genetics*; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D021141:Nucleic Acid Amplification Techniques; D015995:Prevalence; D012307:Risk Factors; D013785:Thailand / Q000453:epidemiology; D020246:Venous Thrombosis / Q000235:genetics*
chemical_list: D005165:Factor V