Antifungal activity of histatin-5 against non-albicans Candida species.
Fungicidal effects of histatin-5 against 26 oral isolates belonging to 5 non-albicans Candida species were examined. Fifty microM of histatin-5 killed more than 95% of Candida tropicalis and Candida guilliermondii isolates and more than 90% of Candida parapsilosis and Candida krusei. However, Candida glabrata was less sensitive to the peptide (mean 62.9%). Our results, taken together, demonstrated that histatin-5 possessed the fungicidal activity against Candida species other than C. glabrata.
Nikawa
H
H
Department of Prosthetic Dentistry, Hiroshima University Faculty of Dentistry, Japan.
Jin
C
C
Fukushima
H
H
Makihira
S
S
Hamada
T
T
D000704:Analysis of Variance; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000145:classification / Q000187:drug effects* / Q000254:growth & development; D015169:Colony Count, Microbial; D054808:Histatins; D006801:Humans; D009055:Mouth / Q000382:microbiology; D011480:Protease Inhibitors / Q000494:pharmacology*; D012471:Salivary Proteins and Peptides / Q000494:pharmacology*; D013223:Statistics as Topic
D000935:Antifungal Agents; C068075:HTN3 protein, human; D054808:Histatins; D011480:Protease Inhibitors; D012471:Salivary Proteins and Peptides