title: Polychlorinated biphenyl congeners as markers of toxic equivalents of polychlorinated biphenyls, dibenzo-p-dioxins and dibenzofurans in breast milk.
abstract: In breast milk, concentrations of polychlorinated biphenyls (PCBs) are higher than those of polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs), making PCB analyses less time-consuming and expensive. We searched for PCB "markers" of PCDD/DF concentrations, by studying associations between concentrations of PCB and PCDD/DFs (expressed as toxic equivalents, TEQs) in breast milk from 27 women (primiparas, 22-35 years). These women donated breast milk in 1996-1999 together with 183 other primiparas from Uppsala County, Sweden. Regression analyses showed that both dioxin-like and non-dioxin-like penta- to hepta-chlorinated PCBs could be used as markers of TEQ concentrations in this group of women, in some cases after age adjustment of the regressions. The strong positive association between concentrations of dioxin-like PCB/DD/DFs and non-dioxin-like PCBs will in future epidemiological studies make it difficult to separate Ah receptor-dependent effects from non-Ah receptor-dependent effects. With the use of regression equations and concentrations in breast milk samples collected in 1994, TEQ concentrations were estimated in the 1994 samples. Comparisons between estimated and measured concentrations indicated that associations between concentrations of marker substances and TEQs should be determined separately within each study population, in order to obtain reliable TEQ exposure assessments from PCB markers.
authors.affiliation: Swedish National Food Administration, Uppsala, SE-751 26, Sweden. glwi@slv.se
authors.forename: A W
authors.initials: AW
authors.lastname: Glynn
authors.forename: S
authors.initials: S
authors.lastname: Atuma
authors.forename: M
authors.initials: M
authors.lastname: Aune
authors.forename: P O
authors.initials: PO
authors.lastname: Darnerud
authors.forename: S
authors.initials: S
authors.lastname: Cnattingius
mesh_terms: D000328:Adult; D000367:Age Factors; D001572:Benzofurans / Q000032:analysis*; D015415:Biomarkers / Q000032:analysis; D004147:Dioxins / Q000032:analysis*; D005260:Female; D006801:Humans; D008895:Milk, Human / Q000737:chemistry*; D015999:Multivariate Analysis; D011078:Polychlorinated Biphenyls / Q000032:analysis*; D012016:Reference Values; D012044:Regression Analysis; D015203:Reproducibility of Results; D013548:Sweden
chemical_list: D001572:Benzofurans; D015415:Biomarkers; D004147:Dioxins; C023614:dibenzofuran; D011078:Polychlorinated Biphenyls