Influence of ketone body and the inhibition of fatty acid oxidation on the food intake of the chick.
1. Fatty acid oxidation is known to be involved in the control of food intake in mammals. The effect of fatty acid oxidation on food intake in chickens was studied using a ketone body (beta-hydroxybutyrate (beta-HB)) and mercaptoacetate (MA) (an inhibitor of fatty acid oxidation). 2. Central and peripheral injection of beta-HB decreased food intake in a dose-dependent manner, while low doses of MA had no effect. Higher doses of MA inhibited feeding but also caused mortality. 3. These results indicate that ketone bodies act as an inhibitory signal for food intake in both the central and peripheral nervous systems but that inhibition of fatty acid oxidation may not be associated with feeding behaviour in chicks.
Sashihara
K
K
Kyushu University, Fukuoka, Japan
Miyamoto
M
M
Ohgushi
A
A
Denbow
D M
DM
Furuse
M
M
D020155:3-Hydroxybutyric Acid / Q000494:pharmacology*; D000818:Animals; D002645:Chickens / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005227:Fatty Acids / Q000378:metabolism*; D007657:Ketone Bodies / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010084:Oxidation-Reduction; D013864:Thioglycolates / Q000494:pharmacology*; D013997:Time Factors
D005227:Fatty Acids; D007657:Ketone Bodies; D013864:Thioglycolates; C017487:2-mercaptoacetate; D020155:3-Hydroxybutyric Acid