Synthesis and structure-activity relationships of benzophenone hydrazone derivatives with insecticidal activity.
A broad range of benzophenone hydrazone derivatives was prepared and tested against selected chewing insect pests, allowing the analysis of structure-activity relationships. Good activity was found only when the aromatic rings were substituted at the 4-positions with an halogen atom and a triflate or perhaloalkoxy group. In contrast, a number of substituents on the hydrazone part led to active compounds, the best results being achieved with acyl-type substituents. The excellent laboratory and greenhouse activity of the best representatives was confirmed in semi-field trials against Spodoptera littoralis.
Böger
M
M
Novartis Crop Protection AG, 4002 Basel, Switzerland.
Dürr
D
D
Gsell
L
L
Hall
R G
RG
Karrer
F
F
Kristiansen
O
O
Maienfisch
P
P
Pascual
A
A
Rindlisbacher
A
A
D000818:Animals; D001577:Benzophenones / Q000138:chemical synthesis* / Q000494:pharmacology; D001681:Biological Assay; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D007306:Insecticides / Q000138:chemical synthesis* / Q000494:pharmacology; D007915:Lepidoptera; D015394:Molecular Structure; D013329:Structure-Activity Relationship
D001577:Benzophenones; D006835:Hydrazones; D007306:Insecticides