Polymorphic exocellular protease expression in clinical isolates of Trichophyton tonsurans.
Tinea capitis continues to be an overwhelmingly prevalent disease in children. Despite the fact that it was recognized over a century ago, the factors that dictate the divergent clinical presentations seen with tinea capitis (e.g., carrier state, chronic non-inflammatory infection, acute severely-inflammatory infection) remain unknown. Given the pathogenic role of exocellular proteases in dermatophyte infections and their potential immunogenic role, this investigation was designed to characterize strain-specific variability in fungal protease expression and activity in Trichophyton tonsurans isolates identified from children with tinea capitis.
Abdel-Rahman
S M
SM
University of Missouri-Kansas City School of Pharmacy, USA. srahman@cmh.edu
D002648:Child; D017364:Collagenases / Q000096:biosynthesis; D010450:Endopeptidases / Q000096:biosynthesis* / Q000145:classification; D006801:Humans; D010196:Pancreatic Elastase / Q000096:biosynthesis; D010447:Peptide Hydrolases / Q000096:biosynthesis; D014006:Tinea Capitis / Q000382:microbiology*; D014249:Trichophyton / Q000201:enzymology* / Q000302:isolation & purification
D010450:Endopeptidases; D010447:Peptide Hydrolases; C035855:keratinase; D010196:Pancreatic Elastase; D017364:Collagenases