Anti-beta 2 glycoprotein 1 and anti-annexin V antibodies in women with recurrent miscarriage.
While it has been established that anti-phospholipid antibodies (aPL) are associated with recurrent miscarriage (RM), the importance of anti-beta2 glycoprotein 1 (GP1) IgG and anti-annexin V IgG antibodies as risk factors for RM is undefined. We have investigated the prevalence of anti-beta2 GP1 IgG and anti-annexin V IgG antibodies in 54 aPL-positive and 48 aPL-negative women with RM. The prevalence of IgG anti-beta2 GP1 antibodies was not significantly different in persistently aPL-positive women with RM (7%), aPL-negative women with RM (6%) and the normal parous control group (3%). Anti-annexin V IgG antibody prevalence was significantly increased in aPL-positive women with RM compared with aPL-negative women with RM (P = 0.01). The elevations were found in 35%, 19% and 16% of aPL-positive women with RM, aPL-negative women with RM and the control group respectively. No women showed positivity for both anti-beta2 GP1 IgG and anti-annexin V antibodies. Anti-beta2 GP1 IgG antibodies do not appear to be contributory to the investigation of women with RM. Anti-annexin V antibody positivity, although associated with aPL positivity in women with RM, is not an independent risk marker.
Arnold
J
J
Department of Haematology, St Mary's Hospital, University College London Hospitals NHS Trust, London, UK.
Holmes
Z
Z
Pickering
W
W
Farmer
C
C
Regan
L
L
Cohen
H
H
D000026:Abortion, Habitual / Q000276:immunology*; D000328:Adult; D017304:Annexin A5 / Q000276:immunology*; D017152:Antibodies, Antiphospholipid / Q000097:blood; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D008875:Middle Aged; D011247:Pregnancy; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000276:immunology*
D017304:Annexin A5; D017152:Antibodies, Antiphospholipid; D001323:Autoantibodies; D007074:Immunoglobulin G; D016682:Lupus Coagulation Inhibitor; D011268:Pregnancy-Specific beta 1-Glycoproteins