title: [Use of lyophilized cellulose in peripheral nerve lesions with loss of substance].
abstract: Lyophilized cellulose was analysed to verify the degree of inflammatory reaction and axon realignment in the sciatic nerve after loss of neural substance. Ten mongrel dogs were divided into: Group 1 - 1 cm section of sciatic nerve which was replaced at lesion site; Group 2 nerve section without fragment replacement. The section site was involved with lyophilized cellulose. Group 3 -1 cm fragment section sutured epineurally. Motor response started at eighth week. Moderate fibrotic reaction to cellulose was seen in Group 1 and 2 animals. Groups 1 and 3 showed coaptation between the nerve and nerve graft with ongoing axons. In Group 2, 1 dog showed regrowth of axons through the empty space. It was concluded that lyophilized cellulose caused moderate fibrous reaction when implanted in peripheral nerve lesions with loss of substance; it can act as envelop protection in those lesions mainly if a neural graft is inserted.
authors.affiliation: Disciplina de Neurocirurgia, Curso de Medicina, Universidade Regional de Blumenau, Blumenau, SC, Brasil.
authors.forename: L R
authors.initials: LR
authors.lastname: Mello
authors.forename: Y
authors.initials: Y
authors.lastname: Feltrin
authors.forename: R
authors.initials: R
authors.lastname: Selbach
authors.forename: G
authors.initials: G
authors.lastname: Macedo
authors.forename: C
authors.initials: C
authors.lastname: Spautz
authors.forename: L J
authors.initials: LJ
authors.lastname: Haas
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D002482:Cellulose / Q000627:therapeutic use*; D004285:Dogs; D005355:Fibrosis; D005612:Freeze Drying; D009416:Nerve Regeneration; D012584:Sciatic Nerve / Q000293:injuries* / Q000473:pathology / Q000502:physiology / Q000601:surgery
chemical_list: D002482:Cellulose