title: Management of inoperable carcinoma of the breast by curative radiotherapy and chemo-hormonotherapy.
abstract: BACKGROUND
  The aim of this study was to evaluate local control and its relation to survival in patients with locally advanced breast cancer treated with curative irradiation and systemic therapy.
  
  
  METHODS
  240 patients with unresectable breast cancer were treated with curative radio- and chemo- or hormonotherapy from 1990-1995. The frequency of distant dissemination and the overall survival of patients with and without complete local control were compared.
  
  
  RESULTS
  Complete local control was achieved in 63% of patients. Complete local control correlated with decrease of distant metastases and increase of survival in comparison with patients without complete local control.
  
  
  CONCLUSIONS
  Radiotherapy without surgery provides insufficient local control in patients with locally advanced breast cancer. Complete local control is an important factor for prevention of distant dissemination and for survival.
authors.affiliation: Department of Oncology and Radiotherapy, Charles University Medical School Teaching Hospital, CR-50005 Hradec Králové, Czech Republic. petera@fnhk.cz
authors.forename: J
authors.initials: J
authors.lastname: Petera
authors.forename: S
authors.initials: S
authors.lastname: Filip
authors.forename: P
authors.initials: P
authors.lastname: Slampa
authors.forename: R
authors.initials: R
authors.lastname: Soumarová
authors.forename: P
authors.initials: P
authors.lastname: Coupek
authors.forename: P
authors.initials: P
authors.lastname: Zatloukal
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage* / Q000009:adverse effects; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000401:mortality / Q000473:pathology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005500:Follow-Up Studies; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D009367:Neoplasm Staging; D011859:Radiography; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate
chemical_list: D018931:Antineoplastic Agents, Hormonal; D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D005472:Fluorouracil; D008727:Methotrexate