title: Association analysis of the 5-HT6 receptor polymorphism C267T with depression in patients with Alzheimer's disease.
abstract: A significant increase of 267C allele of the 5-HT(6) receptor gene has been reported in patients with Alzheimer's disease (AD). Because a deficit in serotonergic neurotransmission is involved in major depression, we tried to find out whether 267C allele is associated with depressive disorders in AD. A psychiatrist interviewed all AD patients and their caregivers for evidence of depression using a Chinese version of the Standard Clinical Interview for DSM-III-R. The difference in the 5-HT(6) genotype or allele distributions between the AD patients with depressive disorders (n = 25) and those without (n = 120) was not significant.
authors.affiliation: Neurological Institute, Taipei Veterans General Hospital, Taipei, Taiwan. hcliu@vghtpe.gov.tw
authors.forename: H C
authors.initials: HC
authors.lastname: Liu
authors.forename: C J
authors.initials: CJ
authors.lastname: Hong
authors.forename: C Y
authors.initials: CY
authors.lastname: Liu
authors.forename: K N
authors.initials: KN
authors.lastname: Lin
authors.forename: S J
authors.initials: SJ
authors.lastname: Tsai
authors.forename: T Y
authors.initials: TY
authors.lastname: Liu
authors.forename: C W
authors.initials: CW
authors.lastname: Chi
authors.forename: P N
authors.initials: PN
authors.lastname: Wang
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000150:complications / Q000235:genetics*; D016022:Case-Control Studies; D003866:Depressive Disorder / Q000150:complications / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008297:Male; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011985:Receptors, Serotonin / Q000235:genetics*; D012720:Severity of Illness Index; D013624:Taiwan
chemical_list: D011985:Receptors, Serotonin; C097216:serotonin 6 receptor