Correlation between cystatin C and serum creatinine as markers of renal function in patients with neoplasms of the locomotor system.
Creatinine levels and clearance are used to monitor renal function in clinical practice. Cystatin C is produced by most nucleated cells in a consistent manner, uninfluenced by inflammatory processes, sex, age, eating habits or nutritional status. Serum cystatin C concentrations are mainly dependent on glomerular activity and are an endogenous biochemical marker of glomerular filtration. The aim of this study was to test the efficiency of cystatin C assay as an alternative marker of renal function. Statistical analysis of our results showed that cystatin C levels were significantly correlated to creatinine and creatinine clearance levels. However, it is still premature to suppose that cystatin C can replace creatinine in routine tests. Establishing cystatin C levels can be useful in cases in which it is not possible to determine creatinine clearance.
Zolezzi
C
C
Laboratory of Medicine, Istituti Ortopedici Rizzoli, Bologna, Italy. carola.zolezzi@ior.it
Ferrari
S
S
Fasano
M C
MC
Telentinis
L
L
Bacci
G
G
Pizzoferrato
A
A
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood* / Q000652:urine; D001859:Bone Neoplasms / Q000097:blood* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood* / Q000652:urine; D055316:Cystatin C; D015891:Cystatins / Q000097:blood* / Q000652:urine; D005260:Female; D006801:Humans; D007668:Kidney / Q000502:physiology*; D007674:Kidney Diseases / Q000097:blood* / Q000652:urine; D007677:Kidney Function Tests; D008297:Male; D012680:Sensitivity and Specificity; D012983:Soft Tissue Neoplasms / Q000097:blood* / Q000652:urine; D016896:Treatment Outcome
D015415:Biomarkers; C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D003404:Creatinine