title: Syndromes with salivary dysfunction predispose to tooth wear: Case reports of congenital dysfunction of major salivary glands, Prader-Willi, congenital rubella, and Sjögren's syndromes.
abstract: Four cases-of congenital dysfunction of the major salivary glands as well as of Prader-Willi, congenital rubella, and Sjögren's syndromes-were identified in a series of 500 patients referred for excessive tooth wear. Although there was evidence of consumption of highly acidic drinks, some occlusal parafunction, and unacceptable toothbrushing habits, salivary dysfunction was the salient factor predisposing a patient to tooth wear in these syndromal cases. The 500 subjects have been characterized either as having medical conditions and medications that predispose them to xerostomia or lifestyles in which workplace- and sports-related dehydration lead to reduced salivary flow. Normal salivation, by buffering capacity, clearance by swallowing, pellicle formation, and capacity for remineralization of demineralized enamel, protects the teeth from extrinsic and intrinsic acids that initiate dental erosion. Thus, the syndromes, unrelated in many respects, underline the importance of normal salivation in the protection of teeth against tooth wear by erosion, attrition, and abrasion.
authors.affiliation: Department of Dentistry, University of Queensland, Australia. j.jors@mailbox.uq.edu.au
authors.forename: W
authors.initials: W
authors.lastname: Young
authors.forename: F
authors.initials: F
authors.lastname: Khan
authors.forename: R
authors.initials: R
authors.lastname: Brandt
authors.forename: N
authors.initials: N
authors.lastname: Savage
authors.forename: A A
authors.initials: AA
authors.lastname: Razek
authors.forename: Q
authors.initials: Q
authors.lastname: Huang
mesh_terms: D000328:Adult; D001628:Beverages / Q000009:adverse effects; D002012:Bruxism / Q000150:complications; D002021:Buffers; D003679:Deglutition / Q000502:physiology; D003741:Dental Deposits / Q000503:physiopathology; D044622:Dental Pellicle; D005247:Feeding Behavior; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008019:Life Style; D008297:Male; D011218:Prader-Willi Syndrome / Q000150:complications* / Q000503:physiopathology; D012409:Rubella / Q000151:congenital* / Q000503:physiopathology; D012463:Saliva / Q000378:metabolism / Q000502:physiology; D012466:Salivary Gland Diseases / Q000150:complications* / Q000151:congenital / Q000503:physiopathology; D012469:Salivary Glands / Q000002:abnormalities; D012472:Salivation / Q000502:physiology; D012636:Secretory Rate / Q000502:physiology; D012859:Sjogren's Syndrome / Q000150:complications* / Q000503:physiopathology; D013577:Syndrome; D014072:Tooth Abrasion / Q000209:etiology*; D019217:Tooth Attrition / Q000209:etiology; D014077:Tooth Erosion / Q000209:etiology; D014099:Toothbrushing / Q000009:adverse effects; D014987:Xerostomia / Q000209:etiology
chemical_list: D002021:Buffers