title: Cytokine kinetics in the plasma of monkeys infected with pathogenic and nonpathogenic simian and human immunodeficiency chimeric viruses at an early stage of infection.
abstract: To evaluate the pattern of cytokines as a result of pathogenic and nonpathogenic SHIV infections in monkeys, we analyzed the cytokines interleukin (IL)-2, IL-4, IL-10, IL-12, and interferon (IFN)-gamma in the plasma of 8 monkeys infected with either pathogenic 89.6P or nonpathogenic NM-3rN chimeric viruses. The cytokine kinetics in the 89.6P-infected monkeys was characterized by increases of IL-2, IL-10, and to some extent IFN-gamma and a decrease of IL-12. Although that of NM-3rN-infected monkeys was characterized by an increase of IFN-gamma, and a transient decrease of IL-12. IL-4 was not detected in any of the monkeys. The results, therefore, showed a mixture of Th-1 and Th-2 cytokine profiles implying these cytokines are not clear enough to use as an index of the pathogenicity of the viruses at an early stage of infection.
authors.affiliation: Research Center for AIDS, Institute for Virus Research, Kyoto University, Kyoto, Japan.
authors.forename: T B
authors.initials: TB
authors.lastname: Kwofie
authors.forename: T
authors.initials: T
authors.lastname: Haga
authors.forename: T
authors.initials: T
authors.lastname: Iida
authors.forename: M
authors.initials: M
authors.lastname: Hayami
authors.forename: T
authors.initials: T
authors.lastname: Miura
mesh_terms: D000818:Animals; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D016207:Cytokines / Q000097:blood*; D015658:HIV Infections / Q000276:immunology* / Q000821:virology; D008251:Macaca; D011995:Recombination, Genetic; D016097:Simian Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology* / Q000821:virology; D015302:Simian Immunodeficiency Virus / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity
chemical_list: D016207:Cytokines