A case of autoimmune hepatitis with a high titer of antimitochondrial antibody and normal gamma-globulinemia.
We report here a patient with chronic active hepatitis who had no markers for hepatitis viruses and no hyper-gamma-globulinemia, but had high titers of antimitochondrial antibody. Serum levels of alkaline phosphatase were normal, and antinuclear antibody, antismooth muscle antibody, and antiliver kidney microsome antibody tested negative. The titers of antimitochondrial antibody exceeded 1:640, and the positivity for anti-M2 was ascertained by using both ELISA and immunoblot with beef-heart mitochondria and a recombinant pyruvate dehydrogenase E2 subunit as antigens. This patient responded to ursodeoxycholic acid (UDCA) therapy in the beginning, but her hepatitis flared up during UDCA therapy. In contrast, she responded completely to corticosteroid therapy. The clinical course and histological findings of this patient strongly suggest that this patient has autoimmune hepatitis.
Shibata
M
M
Second Department of Internal Medicine, Showa University School of Medicine, Tokyo, Japan. sibatami@ja2.so-net.ne.jp
Morizane
T
T
Tanaka
A
A
Onozuka
Y
Y
Uchida
T
T
Gershwin
M E
ME
Mitamura
K
K
D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D002756:Cholagogues and Choleretics / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D019693:Hepatitis, Autoimmune / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D006521:Hepatitis, Chronic / Q000276:immunology; D006801:Humans; D008928:Mitochondria / Q000276:immunology*; D011239:Prednisolone / Q000627:therapeutic use; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use; D005719:gamma-Globulins / Q000032:analysis*
D001323:Autoantibodies; D002756:Cholagogues and Choleretics; D005938:Glucocorticoids; D005719:gamma-Globulins; D014580:Ursodeoxycholic Acid; D011239:Prednisolone