Immunohistochemical evaluation of a malignant phecochromocytoma in a wolfdog.
A malignant pheochromocytoma with multiple metastases was diagnosed in a 7-year-old male wolfdog that resulted from a cross between an eastern timber wolf (Canis lupus lycaon) and an Alaskan malamute. A yellowish white neoplastic mass approximately 10 cm diameter was found in the right adrenal gland. The neoplasm penetrated through the wall of the caudal vena cava. A diagnosis of pheochromocytoma was established by histopathologic and immunohistochemical procedures. Immunohistochemically, the neoplastic cells expressed chromogranin A, substance P, synaptophysin, Leu-7, protein gene product 9.5, methionine-enkephalin, S100 protein, and galanin. Multiple metastatic tumors were found in the kidneys, spleen, lungs, heart, and liver.
Sako
T
T
Department of Veterinary Pathology, School of Veterinary Medicine, Rakuno Gakuen Univeristy, Ebetsu, Hokkaido, Japan.
Kitamura
N
N
Kagawa
Y
Y
Hirayama
K
K
Morita
M
M
Kurosawa
T
T
Yoshino
T
T
Taniyama
H
H
D000310:Adrenal Gland Neoplasms / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D003433:Crosses, Genetic; D004283:Dog Diseases / Q000378:metabolism / Q000473:pathology*; D004285:Dogs; D017809:Fatal Outcome; D007150:Immunohistochemistry / Q000662:veterinary; D007680:Kidney Neoplasms / Q000378:metabolism / Q000473:pathology / Q000556:secondary / Q000662:veterinary*; D008297:Male; D010673:Pheochromocytoma / Q000378:metabolism / Q000473:pathology / Q000556:secondary / Q000662:veterinary*