The selectin superfamily: the role of selectin adhesion molecules in delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage.
Cerebral ischaemia and reperfusion injury may be exacerbated by leukocyte recruitment and activation. Adhesion molecules play a pivotal role in leukocyte recruitment. We report a prospective study of the potential role of the selectin family of adhesion molecules (E-, P- and L-selectin) in delayed cerebral ischaemia (DID) following aneurysmal subarachnoid haemorrhage. In patients with good grade SAH, we have compared serum concentrations of E-, P- and L-selectin, between patients who do, and do not develop delayed cerebral ischaemia. There was no difference in E-selectin concentration between the two groups (44.0 ng/ml vs. 37.4 ng/ml). Serum P-selectin concentration was significantly higher in patients with DID compared to those patients without DID (149.5 ng/ml vs. 112.9 ng/ml, p = 0.039). Serum L-selectin concentrations were significantly lower in patients with DID (633.8 ng/ml vs 897.9 ng/ml, p = 0.013). We conclude that P- and L-selectin are involved in the pathogenesis of DID following aneurysmal subarachnoid haemorrhage. The results of this study do not elucidate the exact role of each selectin in DID.
Nissen
J J
JJ
Department of Neurosurgery, Newcastle General Hospital, Newcastle upon Tyne, UK.
Mantle
D
D
Blackburn
A
A
Barnes
J
J
Wooldridge
T
T
Gregson
B
B
Mendelow
A D
AD
D001921:Brain / Q000098:blood supply; D001929:Brain Edema / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D002545:Brain Ischemia / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D002532:Intracranial Aneurysm / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D011379:Prognosis; D011446:Prospective Studies; D015427:Reperfusion Injury / Q000175:diagnosis / Q000503:physiopathology / Q000601:surgery; D019087:Selectins / Q000502:physiology*; D013345:Subarachnoid Hemorrhage / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery
D019087:Selectins