title: Decreased oxidative stress in patients with idiopathic dilated cardiomyopathy one year after immunoglobulin adsorption.
abstract: OBJECTIVE
  In a substudy to a recently reported investigation that demonstrated the benefit of immunoglobulin adsorption (immunoadsorption) for patients with idiopathic dilated cardiomyopathy (IDC), we tested whether this benefit is associated with a reduction of oxidative stress.
  
  
  BACKGROUND
  The progression of cardiomyopathy is believed to be related to the increase of oxidative stress. Therefore, reduction of oxidative stress could be one of the effects of immunoadsorption for improvement of cardiac performance and clinical status.
  
  
  METHODS
  Plasma markers for oxidative stress-thiobarbituric acid-reactive substances (TBARS), lipid peroxides (LPO), anti-oxidized low-density lipoprotein-autoantibodies (anti-oxLDL-AB), thiol groups and vitamin E-were compared in 31 patients, of whom 16 underwent immunoadsorption and 15 received conventional treatment (controls). All patients received a daily supplement of vitamins, minerals and trace elements.
  
  
  RESULTS
  After one year, TBARS (p = 0.026), LPO (p = 0.026) and anti-oxLD
authors.affiliation: Medizinische Klinik, Humboldt-Universität zu Berlin, Germany. schimke@charite.de
authors.forename: I
authors.initials: I
authors.lastname: Schimke
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: F
authors.initials: F
authors.lastname: Priem
authors.forename: I
authors.initials: I
authors.lastname: Kruse
authors.forename: B
authors.initials: B
authors.lastname: Schön
authors.forename: J
authors.initials: J
authors.lastname: Stein
authors.forename: R
authors.initials: R
authors.lastname: Kunze
authors.forename: G
authors.initials: G
authors.lastname: Wallukat
authors.forename: R
authors.initials: R
authors.lastname: Hetzer
mesh_terms: D000327:Adsorption; D000328:Adult; D001323:Autoantibodies / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D007163:Immunosorbent Techniques; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D018384:Oxidative Stress; D017392:Thiobarbituric Acid Reactive Substances
chemical_list: D001323:Autoantibodies; D007136:Immunoglobulins; D008054:Lipid Peroxides; D017392:Thiobarbituric Acid Reactive Substances