Development and application of a carbonyl-(13)C-enriched backbone amide linker for solid-phase reaction monitoring.
The synthesis and application of a carbonyl-(13)C backbone amide linker are described. The labeled unit is conveniently mixed with commercial resins, providing a rapid means of monitoring chemistry performed with this linker on solid support using conventional (13)C NMR methods.
Jamieson
C
C
Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, CB2 1EW, UK.
Congreve
M S
MS
Hewitt
P R
PR
Scicinski
J J
JJ
Ley
S V
SV