title: In patients with chronic atrial fibrillation and left ventricular systolic dysfunction, restoration of sinus rhythm confers substantial benefit.
abstract: OBJECTIVE
  To evaluate the benefit of sinus rhythm (SR) restoration in patients with chronic controlled atrial fibrillation (AF) and left ventricular systolic dysfunction (LVSD).
  
  
  METHODS
  Prospective case-control study on the short-term outcome (6 to 9 months) of clinical and echocardiographic variables following attempted cardioversion.
  
  
  METHODS
  Outpatient clinic of a university hospital.
  
  
  METHODS
  Fifteen men and 5 women, ranging in age from 40 to 76 years, who had chronic controlled (mean [+/- SD] ventricular rate, 82 +/- 10 beats/min) AF and left ventricular fractional shortening (LVFS) of < 28% at baseline. Control was provided by retrospective paired echocardiographic examinations of six AF patients, plus the study cases with potentially unsuccessful cardioversion or early recurrence of AF.
  
  
  METHODS
  Attempt to restore SR with amiodarone or electrical countershock.
  
  
  RESULTS
  Conversion was attained in 17 patients, but AF recurred early in 4 patients, 3 of whom had proven ischemic LVSD. In the 13 patients with sustained SR, LVFS increased from 20 +/- 4% to 31 +/- 6% (p < 0.0001). In contrast, no changes were detected in the control group (n = 13). This improvement was paralleled by decreases in left ventricular (LV) end-diastolic dimension (from 55 +/- 7 to 51 +/- 6 mm; p = 0.014), LV mass (from 181 +/- 28 to 159 +/- 37 g; p = 0.015), and left atrial diameter (from 45 +/- 9 mm to 42 +/- 7; p = 0.003). A marked decrease in heart rate (from 82 +/- 9 to 64 +/- 5 beats/min; p < 0.0001) and a reduction in New York Heart Association functional class (from 2.3 +/- 0.9 to 1.2 +/- 0.4; p = 0.0007) also were observed in patients with sustained SR but not among subjects in the control group.
  
  
  CONCLUSIONS
  Even when adequate control of the ventricular rate has been achieved, the LV function of patients with chronic AF greatly improves after restoration and maintenance of SR.
authors.affiliation: Division of Cardiology, Virgen de las Nieves University Hospital, Granada, Spain. jazpitarte@lettera.net
authors.forename: J
authors.initials: J
authors.lastname: Azpitarte
authors.forename: O
authors.initials: O
authors.lastname: Baún
authors.forename: E
authors.initials: E
authors.lastname: Moreno
authors.forename: R
authors.initials: R
authors.lastname: García-Orta
authors.forename: J
authors.initials: J
authors.lastname: Sánchez-Ramos
authors.forename: L
authors.initials: L
authors.lastname: Tercedor
mesh_terms: D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D016022:Case-Control Studies; D002908:Chronic Disease; D004452:Echocardiography; D004554:Electric Countershock; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D011446:Prospective Studies; D013599:Systole; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology
chemical_list: D000889:Anti-Arrhythmia Agents