title: The application of non-combinatorial chemistry to lead discovery.
abstract: Non-combinatorial chemistry is a powerful technology for the synthesis of large numbers of compounds, with complete control over the properties of those compounds. We have developed a Library Creation, Registration and Automation system (LiCRA), which harnesses an efficient non-combinatorial chemistry design and synthesis engine, together with high-throughput automated purification. This LiCRA system also operates in a closed loop mode for hit-to-lead optimization, and contains an integrated IT system that controls and facilitates all aspects of the operation from design to registration. Quality has been our watchword, from the quality of compound design through to the quality of the products.
authors.affiliation: Medicinal TechnologiesPfizer Global R&D, CT13 9NJ, SandwichKent, UK
authors.forename: J
authors.initials: J
authors.lastname: Everett
authors.forename: M
authors.initials: M
authors.lastname: Gardner
authors.forename: F
authors.initials: F
authors.lastname: Pullen
authors.forename: G F.
authors.initials: GF
authors.lastname: Smith
authors.forename: M
authors.initials: M
authors.lastname: Snarey
authors.forename: N
authors.initials: N
authors.lastname: Terrett