Islet transplantation: present clinical situation and future aspects.
Beta-cell replacement either by pancreatic organ or islet cell transplantation is the only treatment to achieve an insulin-independent, normoglycemic state and to avoid hypoglycemic episodes in patients with type 1 diabetes mellitus. This article will review the state-of-the-art in clinical islet cell transplantation at the dawn of the new millennium and will provide an outlook on the basis of extended personal experience.
Bretzel
R G
RG
Third Medical Department and Policlinic, Justus-Liebig-University, Giessen, Germany. reinhard.bretzel@innere.med.uni-giessen.de
Brendel
M
M
Eckhard
M
M
Brandhorst
D
D
Jaeger
C
C
Hatziagelaki
E
E
Federlin
K
K
D006084:Graft Rejection; D006801:Humans; D007391:International Cooperation; D016381:Islets of Langerhans Transplantation / Q000639:trends; D012042:Registries