title: Community-acquired pneumonia in Ugandan adults: short-term parenteral ampicillin therapy for bacterial pneumonia.
abstract: A hospital-based prospective study of 99 patients with community-acquired pneumonia (CAP) was carried out in Kampala, Uganda. We evaluated microbiological etiologies, clinical features and effectiveness of short-term parenteral ampicillin followed by oral amoxicillin for these patients in relation to HIV-status. We demonstrated a very high prevalence (75%) of HIV-1 infection. No significant difference was observed with respect to age, gender, prior antibiotic usage, symptoms, laboratory data or bacterial etiology between HIV-1-infected and HIV-uninfected CAP patients. Most strains of Streptococcus pneumoniae (n = 19) and Haemophilus influenzae (n = 8) isolated from HIV-1-infected patients were penicillin-resistant (95%) and beta-lactamase producing (75%) strains, respectively. A high percentage of good clinical response was found in both HIV-1-infected (81%) and HIV-uninfected (86%) among 39 patients with CAP due to a defined bacterial pathogen. These data support the use of short-term parenteral ampicillin for patients with bacterial CAP irrespective of HIV-status.
authors.affiliation: Department of Internal Medicine and Information and Reference Center, Institute of Tropical Medicine, Nagasaki University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yoshimine
authors.forename: K
authors.initials: K
authors.lastname: Oishi
authors.forename: F
authors.initials: F
authors.lastname: Mubiru
authors.forename: H
authors.initials: H
authors.lastname: Nalwoga
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Amano
authors.forename: P
authors.initials: P
authors.lastname: Ombasi
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: M
authors.initials: M
authors.lastname: Joloba
authors.forename: T
authors.initials: T
authors.lastname: Aisu
authors.forename: K
authors.initials: K
authors.lastname: Ahmed
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: R
authors.initials: R
authors.lastname: Mugerwa
authors.forename: T
authors.initials: T
authors.lastname: Nagatake
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage; D000667:Ampicillin / Q000008:administration & dosage*; D017714:Community-Acquired Infections / Q000150:complications / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004352:Drug Resistance, Microbial; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000453:epidemiology*; D015497:HIV-1 / Q000302:isolation & purification*; D006193:Haemophilus influenzae / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage*; D018410:Pneumonia, Bacterial / Q000150:complications / Q000188:drug therapy*; D015995:Prevalence; D011446:Prospective Studies; D013296:Streptococcus pneumoniae / Q000187:drug effects; D016896:Treatment Outcome; D014454:Uganda / Q000453:epidemiology
chemical_list: D010406:Penicillins; D000667:Ampicillin; D000658:Amoxicillin