Blood:air partition coefficients of individual and mixtures of trihalomethanes.
The objective of the present study was to determine the rat blood:air partition coefficients (P(b:a)) of chloroform, bromodichloromethane, dibromochloromethane and bromoform present in vitro individually or as mixtures. The experimentally determined P(b:a) of chloroform, bromodichloromethane, dibromochloromethane and bromoform present individually corresponded to (mean +/- SD, n = 8) 21.3 +/- 1.8, 41.8 +/- 6.2, 97.5 +/- 4.1, and 187 +/- 7.4, respectively. The P(b:a) of these trihalomethanes (THMs) showed a decreasing trend during mixed in vitro exposures to 0.138 +/- 0.002 or 0.273 +/- 0.002 micromol of each of the four THMs. In general, the P(b:a) determined during mixed exposures differed by < or = 15% of the average P(b:a) determined for THMs present individually. The results of this study suggest that an alteration of P(b:a) of the individual THMs is unlikely to occur at the blood concentrations of THMs observed during mixed exposures in rats.
Béliveau
M
M
Département de santé environnementale et santé au travail, Faculté de médecine, Université de Montréal, PQ, Canada.
Charest-Tardif
G
G
Krishnan
K
K
D000818:Animals; D002273:Carcinogens / Q000493:pharmacokinetics*; D002725:Chloroform / Q000097:blood*; D004781:Environmental Exposure; D005740:Gases; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012997:Solvents / Q000493:pharmacokinetics*; D022882:Trihalomethanes / Q000097:blood*
D002273:Carcinogens; D005740:Gases; D012997:Solvents; D022882:Trihalomethanes; C032707:chlorodibromomethane; C025191:bromodichloromethane; D002725:Chloroform; C015044:bromoform