Molecular physiology of renal p-aminohippurate secretion.
Renal proximal tubules secrete various organic anions, including drugs and p-aminohippurate (PAH). Uptake of PAH from blood into tubule cells occurs by exchange with intracellular alpha-ketoglutarate and is mediated by the organic anion transporter 1. PAH exit into tubule lumen is species specific and may involve ATP-independent and -dependent transporters.
Burckhardt
G
G
Zentrum Physiologie und Pathophysiologie, Georg-August-Universität, 37073 Göttingen, Germany.
Bahn
A
A
Wolff
N A
NA
D000818:Animals; D027321:Anion Transport Proteins; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D007656:Ketoglutaric Acids / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000166:cytology / Q000378:metabolism; D010130:p-Aminohippuric Acid / Q000378:metabolism*
D027321:Anion Transport Proteins; D002352:Carrier Proteins; D007656:Ketoglutaric Acids; D010130:p-Aminohippuric Acid