title: The effect of cold air cooling on 585 nm pulsed dye laser treatment of port-wine stains.
abstract: BACKGROUND
  The use of cryogen spray cooling in the course of dye laser treatment of port-wine stains has established itself in recent years because of its good analgesic and epidermally protective effects. The disadvantages of this kind of evaporative cooling are the cost and, in the case of dichlorodifluoromethane, the effects on the ozone layer. Cold air is an innovative cooling method that costs nearly nothing to use, is environmentally friendly, and can be easily adapted to existing laser systems.
  
  
  OBJECTIVE
  To examine and evaluate cold air cooling as an alternative method of cooling in laser treatment.
  
  
  METHODS
  In a prospective study, 13 patients (9 female, 4 male) with port-wine stains were treated with a pulsed dye laser (lambda = 585 nm, tau(p) = 450 microsec). In every case, either the entire area or a sample area of the port-wine stain was treated with cold air cooling on 50% of the surface and without on the other 50%. Clearance, analgesia, and adverse and concomitant effects were assessed.
  
  
  RESULTS
  In nine patients (69%) there were similar results in terms of clearance. In four cases, better lightening results (in two patients) and worse lightening results (in two other patients) were achieved in the area treated with cold air. Nine of the patients (69%) felt that the laser impulses accompanied by cold air were significantly less painful. Adverse effects (purpura, erythema, edema) and concomitant effects (hypopigmentation, hyperpigmentation, scars) were much less marked in the cooled areas.
  
  
  CONCLUSIONS
  Cold air is a safe and effective alternative to cryogen spray cooling. It is easy to use, economical, and environmentally friendly. Continuing studies are necessary to determine if there are interactions which affect the tissue.
authors.affiliation: Laserklinik Karlsruhe, Karlsruhe, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Greve
authors.forename: S
authors.initials: S
authors.lastname: Hammes
authors.forename: C
authors.initials: C
authors.lastname: Raulin
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003080:Cold Temperature; D005260:Female; D006801:Humans; D007223:Infant; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D019339:Port-Wine Stain / Q000473:pathology / Q000532:radiotherapy*; D011446:Prospective Studies