title: Vertebrate limb development--the early stages in chick and mouse.
abstract: More news this year about FGFs and their roles in vertebrate limb initiation; Wnt signalling is shown for the first time to be another component of the signalling cascade involved in early limb formation. Ectodermal compartments that control apical ridge formation were previously described in chick embryos and are now shown to exist in mouse embryos; Engrailed1 is expressed in the ventral ectodermal compartment but experiments in both chick and mouse show that it is not responsible for compartment specification.
authors.affiliation: Division of Cell and Developmental Biology, School of Life Sciences, MSI/WTB complex, University of Dundee, Dow Street, DD1 5EH, Dundee, UK. c.a.tickle@dundee.ac.uk
authors.forename: C
authors.initials: C
authors.lastname: Tickle
authors.forename: A
authors.initials: A
authors.lastname: Münsterberg
mesh_terms: D000818:Animals; D002642:Chick Embryo; D005121:Extremities / Q000196:embryology*; D005346:Fibroblast Growth Factors / Q000378:metabolism* / Q000494:pharmacology; D018878:Limb Buds; D051379:Mice; D011518:Proto-Oncogene Proteins / Q000378:metabolism* / Q000494:pharmacology; D015398:Signal Transduction; D013997:Time Factors; D014714:Vertebrates; D051153:Wnt Proteins; D029961:Zebrafish Proteins
chemical_list: D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D029961:Zebrafish Proteins; D005346:Fibroblast Growth Factors