title: Mechanical prophylaxis against deep-vein thrombosis after pelvic and acetabular fractures.
abstract: BACKGROUND
  Deep-vein thrombosis is a common complication following pelvic and acetabular fractures. The hypothesis of this study was that pulsatile mechanical compression is superior to standard sequential mechanical compression for decreasing the prevalence of deep-vein thrombosis in patients with pelvic or acetabular fracture.
  
  
  METHODS
  A prospective, randomized, blinded study of two methods of mechanical prophylaxis against deep-vein thrombosis was conducted. One hundred and seven patients were randomized into either Group A (fifty-four patients), in which a thigh-calf low-pressure sequential-compression device was used, or Group B (fifty-three patients), in which a calf-foot high-pressure pulsatile-compression pump was used. All patients underwent duplex ultrasonography and magnetic resonance venography. The two groups were comparable with regard to demographics, fracture type, fracture treatment, time from the injury to the prophylaxis, and patient compliance.
  
  
  RESULTS
  Deep-vein thrombosis developed in ten patients (19%) in Group A, with seven (13%) having a large or occlusive clot and one (2%) having a documented pulmonary embolism. Deep-vein thrombosis developed in five patients (9%) in Group B, with two (4%) having a large or occlusive clot and none having a documented pulmonary embolism. Nine of the nineteen detected thromboses were in the deep pelvic veins. The difference in the prevalence of large or occlusive clots between the two groups demonstrated a trend but, with the numbers available, was not significant (p = 0.16). Increased patient age and the time elapsed from the injury to the surgery were found to be associated with higher rates of thrombosis.
  
  
  CONCLUSIONS
  Pulsatile compression was associated with fewer deep-vein thromboses than was standard compression, with the difference representing a trend but not reaching significance with the number of patients studied.
authors.affiliation: Department of Orthopaedics Surgery, University of Alabama Hospital, Birmingham 35294-3295, USA. james.stannard@ortho.uab.edu
authors.forename: J P
authors.initials: JP
authors.lastname: Stannard
authors.forename: R S
authors.initials: RS
authors.lastname: Riley
authors.forename: M D
authors.initials: MD
authors.lastname: McClenney
authors.forename: R R
authors.initials: RR
authors.lastname: Lopez-Ben
authors.forename: D A
authors.initials: DA
authors.lastname: Volgas
authors.forename: J E
authors.initials: JE
authors.lastname: Alonso
mesh_terms: D000077:Acetabulum / Q000293:injuries / Q000601:surgery; D000328:Adult; D017677:Age Distribution; D000368:Aged; D001458:Bandages; D004311:Double-Blind Method; D005260:Female; D005593:Fracture Fixation, Internal / Q000379:methods; D050723:Fractures, Bone / Q000150:complications* / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010384:Pelvic Bones / Q000293:injuries* / Q000601:surgery; D010690:Phlebography; D011300:Preoperative Care / Q000379:methods*; D011336:Probability; D011379:Prognosis; D011446:Prospective Studies; D018570:Risk Assessment; D012680:Sensitivity and Specificity; D020246:Venous Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology / Q000517:prevention & control*; D014949:Wounds, Nonpenetrating / Q000150:complications*