title: The cornea in young myopic adults.
abstract: OBJECTIVE
  To further understand the effect of refractive error on the corneal dimensions and function.
  
  
  METHODS
  Corneal curvature, corneal thickness, and axial length measurements were performed, as well as specular microscopy and fluorophotometry, on patients with various refractive statuses. 216 subjects, mean age 22.2 (SD 4.2) years, were examined. Patients with previous contact lens wear history, external eye diseases, as well as previous ocular surgeries, were excluded.
  
  
  RESULTS
  The corneas were flatter in eyes with longer axial length (r = -0.22, p = 0.003). Eyes with more myopic spherical equivalent had longer axial length (r = -0.90, p <0.001) as well as less corneal endothelial density (r = 0.20, p = 0.037). Corneal endothelial density decreased in eyes with longer axial length (r = 0.24, p = 0.019); however, it correlated neither with corneal thickness (r = -0.06, p = 0.59) nor with corneal curvature (r = -0.07, p = 0.52). The corneas had a mean corneal thickness of 533 (SD 29) microm and were thinner in more myopic eyes (r = 0.16, p = 0.021). The corneas tended to be thinner in eyes with longer axial length. However, the correlation did not reach statistical significance (r = -0.11, p = 0.14). Besides, there was no significant correlation between the corneal thickness and the corneal curvature (r = -0.13, p = 0.093) and the endothelial permeability (r = 0.042, p = 0.69). The corneas with higher endothelial density had larger corneal transfer coefficient (r = 0.26, p = 0.024) and higher permeability to fluorescein molecules (r = 0.28, p = 0.014). Nevertheless, the corneal endothelial permeability did not correlate significantly with either the axial length (r = -0.18, p = 0.11) or the degree of myopia (r = 0.12, p = 0.26).
  
  
  CONCLUSIONS
  Changes in the anterior segments as the eyeball elongates in myopia progression included flatter corneal curvature, decreased corneal thickness, as well as decreased endothelial density. These factors should be considered in refractive surgery.
authors.affiliation: Department of Ophthalmology, Chang Gung Memorial Hospital, Chang Gung University, Taiwan. shuwenchang@cgmh.org.tw
authors.forename: S W
authors.initials: SW
authors.lastname: Chang
authors.forename: I L
authors.initials: IL
authors.lastname: Tsai
authors.forename: F R
authors.initials: FR
authors.lastname: Hu
authors.forename: L L
authors.initials: LL
authors.lastname: Lin
authors.forename: Y F
authors.initials: YF
authors.lastname: Shih
mesh_terms: D000328:Adult; D003319:Corneal Stroma / Q000473:pathology; D019781:Corneal Topography; D004728:Endothelium, Corneal / Q000378:metabolism / Q000473:pathology; D005260:Female; D019793:Fluorescein / Q000493:pharmacokinetics; D015590:Fluorophotometry; D006801:Humans; D008297:Male; D009216:Myopia / Q000378:metabolism / Q000473:pathology*; D010539:Permeability; D012029:Refraction, Ocular; D012737:Sex Factors; D018709:Statistics, Nonparametric
chemical_list: D019793:Fluorescein