title: Redistribution in I-123 N-isopropyl-p iodoamphetamine single-photon emission computed tomography in cerebrovascular disease and the effects of rehabilitation.
abstract: We performed N-isopropyl-p (I-123) iodoamphetamine (IMP) single-photon emission computed tomography (SPECT) on 28 patients with severe cerebrovascular disease before rehabilitation, and compared the degree of redistribution and the assessment of activities of daily living (ADL). We calculated a redistribution (RD) ratio in the central and peripheral parts of the lesions: RD ratio (c) and RD ratio (p). We classified the patients into four groups based on the degree of redistribution: complete: both RD ratio (c) and (p) > or = 75; peripheral: RD ratio (c) < 75, RD ratio (p) > or = 75; incomplete: both RD ratio (c) and (p) < 75 and at least one of RD ratio (c) or (p) > or = 25; no redistribution: both RD ratio (c) and (p) < 25. We assessed the ADL using the modified Barthel index (BI). deltaBI was defined as BI after rehabilitation-BI before rehabilitation (BIpost-BIpre). The deltaBI of the four groups were as follows: complete-redistribution group (40.8 +/- 22.8), peripheral-redistribution group (40.0 +/- 15.8), incomplete-redistribution group (27.2 +/- 22.6), no-redistribution group (8.8 +/- 12.3). The deltaBI of the complete and peripheral redistribution groups were significantly higher than that of the no-redistribution group. However, deltaBI was almost the same in the complete- and peripheral-redistribution groups. This suggests that the effect of rehabilitation might be closely related to the viability of the peripheral part of the lesion.
authors.affiliation: Department of Radiology, Jikei University School of Medicine, Tokyo, Japan. GZL13162@niftyserve.ne.jp
authors.forename: N
authors.initials: N
authors.lastname: Fukumitsu
authors.forename: S
authors.initials: S
authors.lastname: Ogi
authors.forename: G
authors.initials: G
authors.lastname: Kawakami
authors.forename: M
authors.initials: M
authors.lastname: Uchiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Mori
authors.forename: I
authors.initials: I
authors.lastname: Takehara
authors.forename: N
authors.initials: N
authors.lastname: Katagiri
authors.forename: S
authors.initials: S
authors.lastname: Miyano
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging / Q000534:rehabilitation*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000534:rehabilitation*; D005260:Female; D006801:Humans; D020367:Iofetamine / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D019275:Radiopharmaceuticals / Q000493:pharmacokinetics*; D012044:Regression Analysis; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D019275:Radiopharmaceuticals; D020367:Iofetamine