Solid-supported benzotriazoles. 2. Synthetic auxiliaries and traceless linkers for the combinatorial synthesis of unsymmetrical ureas.
Resin-bound benzotriazole chemistry applied to the solid-phase synthesis of arrays of unsymmetrical aryl ureas is described here. The chemistry assessment process, the monomer rehearsal, the preparation of a discrete library by automated parallel synthesis, the parallel purification protocol employing solid-phase scavenging, and the complete analytical characterization of the library components are also presented.
Paio
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A
Glaxo Wellcome Medicines Research Centre, Via A. Fleming 4, 37135 Verona, Italy.
Crespo
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RF
Seneci
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P
Ciraco
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