Tetanus antibody levels of female volunteers after injection with solvent/detergent-treated human tetanus immunoglobulin (Tetabulin S/D).
OBJECTIVE
The aim of this study was to analyse the increase of antitetanus titre in volunteers following injection with human tetanus immunoglobulin (HTI).


METHODS
Twelve females with tetanus antibody titres of < or = 0.05 international units (IU)/ml were injected with 500 IU of human tetanus immunoglobulin (Tetabulin S/D). The tetanus antibody titres were determined before injection, and after 30 h, 48 h and 4 days.


RESULTS
A fast and sustained increase of protective tetanus antibody levels was observed in 10 of 12 volunteers. No adverse events related to the study drug were reported.


CONCLUSIONS
HTI confers rapid and effective immunity to tetanus.
Wahlberg
T
T
Bio-Link AB, Götgatan 61, S-116 21 Stockholm, Sweden. bio-link@mbox318.swipnet.se
Leibl
H
H
Brauner
A
A
Kirgios
M
M
Adner
N
N
D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood*; D003902:Detergents / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage* / Q000009:adverse effects / Q000302:isolation & purification; D008875:Middle Aged; D012997:Solvents / Q000494:pharmacology*; D013745:Tetanus Toxoid / Q000276:immunology; D014611:Vaccination
D000907:Antibodies, Bacterial; D003902:Detergents; D007136:Immunoglobulins; D012997:Solvents; C440498:Tetabulin S; D013745:Tetanus Toxoid