title: Induction of C-reactive protein, serum amyloid P component, and kininogens in the submandibular and lacrimal glands of rats with experimentally induced inflammation.
abstract: The mRNAs for acute-phase proteins and kininogens were found to be increased in the submandibular gland (SMG) and extraorbital and intraorbital lacrimal gland (ELG and ILG) in response to experimentally induced inflammation in rats; i.e., 24 hours after subcutaneous injection of turpentine oil, mRNAs for C-reactive protein (CRP), serum amyloid P component (SAP), and H- and T-kininogens were induced in the SMG, ELG, and ILG of rats, whereas these mRNAs were not detected in the same tissues of normal control rats. The induction of mRNAs for these inflammatory proteins by turpentine oil was preceded by a transient increase in the level of mRNA for tumor necrosis factor-alpha (TNF-alpha) at 6 hours after subcutaneous injection of the oil. This was confirmed by injection of another inflammation inducer, lipopolysaccharide (LPS), which induced the TNF-alpha mRNA in the same way at 6 hours as turpentine oil did. The up-regulation of acute-phase proteins including kininogens in the SMG, ELG, and ILG suggest the existence of a strict defense system in the exocrine glands.
authors.affiliation: Department of Physiology and Oral Physiology, Tokushima University, School of Dentistry, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Wei
authors.forename: N
authors.initials: N
authors.lastname: Parvin
authors.forename: K
authors.initials: K
authors.lastname: Tsumura
authors.forename: T
authors.initials: T
authors.lastname: Akamatsu
authors.forename: J
authors.initials: J
authors.lastname: Tada
authors.forename: N
authors.initials: N
authors.lastname: Kanamori
authors.forename: K
authors.initials: K
authors.lastname: Hosoi
mesh_terms: D000818:Animals; D002097:C-Reactive Protein / Q000096:biosynthesis* / Q000235:genetics; D003607:Dacryocystitis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D007279:Injections, Subcutaneous; D007509:Irritants / Q000008:administration & dosage / Q000633:toxicity; D007704:Kininogens / Q000096:biosynthesis* / Q000235:genetics; D007765:Lacrimal Apparatus / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012793:Sialadenitis / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D013364:Submandibular Gland Diseases / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000235:genetics; D014425:Turpentine / Q000008:administration & dosage / Q000633:toxicity
chemical_list: D007509:Irritants; D007704:Kininogens; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D014425:Turpentine