Response to HBV vaccine in relation to vaccine dose and anti-HCV positivity: a New South Wales correctional facilities' study.
Currently, about two-thirds of inmates in NSW correctional facilities have a history of injection drug use, and about half have serological evidence of exposure to hepatitis C virus. The introduction of an accelerated hepatitis B vaccination program (0-1-2 months) in 1998, using a 20 microg/dose vaccine was necessitated by the need to vaccinate eligible inmates in this high-risk environment characterised by rapid client mobility. Since 1999, both 10 and 20 microg doses of vaccine were introduced. We found that sero-response rates were not significantly influenced by HCV antibody status, but were significantly lower in cohorts of inmates vaccinated with the 10 microg dose of vaccine.
Awofeso
N
N
New South Wales Corrections Health Service, P.O. Box 150, NSW 2036, Matraville, Australia. niyiawofeso@hotmail.com
Levy
M
M
Harper
S
S
Jones
M
M
Hayes
M
M
Douglas
J
J
Fisher
M
M
Folpp
D
D
D004306:Dose-Response Relationship, Immunologic; D017325:Hepatitis B Vaccines / Q000276:immunology*; D018937:Hepatitis C Antibodies / Q000097:blood*; D006801:Humans; D014611:Vaccination
D017325:Hepatitis B Vaccines; D018937:Hepatitis C Antibodies