title: SOCS1 deficiency results in accelerated mammary gland development and rescues lactation in prolactin receptor-deficient mice.
abstract: Prolactin is essential for proliferation and differentiation of the developing mammary gland. We have explored a role for Suppressor of Cytokine Signaling 1 (SOCS1) as a modulator of the prolactin response using mice deficient in SOCS1, which were rescued from neonatal death by deletion of the Interferon gamma (IFN gamma) gene. SOCS1(-/-)/IFN gamma(-/-) mice exhibited accelerated lobuloalveolar development in the mammary gland during late pregnancy and precocious lactation. Significantly, the lactogenic defect in prolactin receptor heterozygous females could be rescued by deletion of a single SOCS1 allele. These findings establish a role for SOCS1 as a negative regulator of prolactin signaling and suggest that SOCS1 is required for the prevention of lactation prior to parturition.
authors.affiliation: The Walter and Eliza Hall Institute of Medical Research, Bone Marrow Research Laboratories, PO Royal Melbourne Hospital, VIC 3050, Australia.
authors.forename: G J
authors.initials: GJ
authors.lastname: Lindeman
authors.forename: S
authors.initials: S
authors.lastname: Wittlin
authors.forename: H
authors.initials: H
authors.lastname: Lada
authors.forename: M J
authors.initials: MJ
authors.lastname: Naylor
authors.forename: M
authors.initials: M
authors.lastname: Santamaria
authors.forename: J G
authors.initials: JG
authors.lastname: Zhang
authors.forename: R
authors.initials: R
authors.lastname: Starr
authors.forename: D J
authors.initials: DJ
authors.lastname: Hilton
authors.forename: W S
authors.initials: WS
authors.lastname: Alexander
authors.forename: C J
authors.initials: CJ
authors.lastname: Ormandy
authors.forename: J
authors.initials: J
authors.lastname: Visvader
mesh_terms: D000483:Alleles; D000818:Animals; D001940:Breast / Q000254:growth & development*; D002352:Carrier Proteins / Q000235:genetics / Q000502:physiology*; D002364:Caseins / Q000096:biosynthesis; D002460:Cell Line; D005260:Female; D015870:Gene Expression; D007774:Lactation / Q000502:physiology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D008892:Milk / Q000378:metabolism; D011247:Pregnancy; D011981:Receptors, Prolactin / Q000235:genetics / Q000502:physiology*; D012097:Repressor Proteins; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins
chemical_list: D002352:Carrier Proteins; D002364:Caseins; D011981:Receptors, Prolactin; D012097:Repressor Proteins; C491590:Socs1 protein, mouse; D000071222:Suppressor of Cytokine Signaling 1 Protein; D050826:Suppressor of Cytokine Signaling Proteins