Hypoxia-dependent protein expression: erythropoietin.
Normal cell homeostasis relies on the ordered flow of nutrients and substrates through metabolic pathways. Any perturbation of this flow eventually leads to dysfunction, impairment of defense mechanisms, loss of viability and death. High altitude and pathological hypoxia represent a serious and frequent cause for the loss of cell viability. Although organisms customarily respond by triggering adaptive or maladaptive mechanisms, all forms of life eventually succumb to hypoxia if it is severe enough, irrespectively of the primary cause. This paper reviews one of the mechanisms by which organisms respond to hypoxia: erythropoiesis. Although such response is not always beneficial, the discovery of the biochemical mechanisms underlying erythropoiesis has triggered an active field of research that is actually applying lessons learned in the mountains to a more clinical environment.
Samaja
M
M
Dipartimento di Medicina, Chirurgia e Odontoiatria, Università di Milano, Milan, Italy. Michele.Samaja@unimi.it
D000222:Adaptation, Physiological / Q000235:genetics*; D004921:Erythropoietin / Q000235:genetics*; D005786:Gene Expression Regulation; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*
D004921:Erythropoietin