[Oxidative stress in pathogenesis of arterial hypertension in ISIAH rats].
The NO-synthase activity and the rate of NO production in the rat aortic wall and cerebellum were 2-1.5-fold higher in the ISIAH rats than in normotensive WAG rat strain. In contrast, the superoxide dismutase (SOD) activity was significantly reduced in the ISIAH rats. The blood level of reduced thiols was also much lower in the ISIAH rats. The findings suggest that oxidative stress may play a significant role in pathogenesis of stress-sensitive hypertension in the ISIAH rat strain.
Markel'
A L
AL
Institute of Cytology and Genetics, Russian Acad. Sci., Siberian Branch, Russia, 630090, Novosibirsk, Pr. Lavrentyeva, 10.
Elinova
V I
VI
Khramtsov
V V
VV
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001794:Blood Pressure; D004578:Electron Spin Resonance Spectroscopy; D006973:Hypertension / Q000209:etiology / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D019001:Nitric Oxide Synthase / Q000378:metabolism; D018384:Oxidative Stress; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000150:complications / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism
D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase