title: Epstein-Barr virus involvement is mainly restricted to lymphoepithelial type of gastric carcinoma among various epithelial neoplasms.
abstract: To demonstrate the association of Epstein-Barr virus (EBV) with primary epithelial neoplasms in the south part of Kyushu, Japan, 761 carcinomas consisting of 75 lung, 61 breast, 107 esophagus, 102 colon, 58 pancreas, 45 thyroid, and 313 gastric cancers were examined by EBER-1 in situ hybridization. EBER-1 was detected in 23 cases (7.3%) out of 313 gastric carcinomas, while none of the other carcinomas was positive for EBER-1. Twenty-eight (9.4%) out of 313 gastric carcinomas were differentiated poorly to moderately carcinomas with prominent lymphoid cell infiltration, similar to so-called lymphoepithelioma-like carcinoma, and 19 cases (67.9%) were positive for EBER-1. Although two (2.6%) and 11(10.3%) out of 75 lung and 107 esophagus carcinomas were so-called lymphoepithelioma-like carcinomas, respectively, but EBER-1 was not detected in other epithelial neoplasms that originated from the lung, esophagus, breast, colon, pancreas, and thyroid in the south of Kyushu, Japan. As a result, EBV was associated with only some gastric carcinomas but not with other epithelial neoplasms originating from the lung, esophagus, breast, colon, pancreas, and thyroid in southern Japan.
authors.affiliation: The First Department of Surgery, Faculty of Medicine, Kagoshima University, Kagoshima, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kijima
authors.forename: S
authors.initials: S
authors.lastname: Hokita
authors.forename: S
authors.initials: S
authors.lastname: Takao
authors.forename: M
authors.initials: M
authors.lastname: Baba
authors.forename: S
authors.initials: S
authors.lastname: Natsugoe
authors.forename: H
authors.initials: H
authors.lastname: Yoshinaka
authors.forename: K
authors.initials: K
authors.lastname: Aridome
authors.forename: T
authors.initials: T
authors.lastname: Otsuji
authors.forename: T
authors.initials: T
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Tokunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Eizuru
authors.forename: T
authors.initials: T
authors.lastname: Aikou
mesh_terms: D000230:Adenocarcinoma / Q000821:virology*; D001943:Breast Neoplasms; D003110:Colonic Neoplasms; D020031:Epstein-Barr Virus Infections / Q000821:virology*; D004938:Esophageal Neoplasms; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D017403:In Situ Hybridization; D007564:Japan; D008175:Lung Neoplasms; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms; D012367:RNA, Viral / Q000032:analysis; D013274:Stomach Neoplasms / Q000821:virology*; D013964:Thyroid Neoplasms
chemical_list: C099537:Epstein-Barr virus encoded RNA 1; D012367:RNA, Viral