title: Analysis of virus-specific CD4(+) t cells during long-term gammaherpesvirus infection.
abstract: Major histocompatibility complex class II-mediated antigen presentation after intranasal infection with murine gammaherpesvirus 68 differs in mediastinal lymph nodes and spleen. Evidence that virus-specific CD4(+) T cells were being stimulated was found as late as 6 to 8 months after infection, and cells specific for the viral gp150(67-83) and ORF11(168-180) peptides were maintained as a fairly stable proportion of the total response.
authors.affiliation: Department of Immunology, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors.forename: E
authors.initials: E
authors.lastname: Flaño
authors.forename: D L
authors.initials: DL
authors.lastname: Woodland
authors.forename: M A
authors.initials: MA
authors.lastname: Blackman
authors.forename: P C
authors.initials: PC
authors.lastname: Doherty
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D018142:Gammaherpesvirinae; D006566:Herpesviridae Infections / Q000276:immunology*; D007111:Immunity, Cellular; D051379:Mice; D013997:Time Factors
chemical_list: D000956:Antigens, Viral