title: Evidence for central organization of cardiovascular rhythms.
abstract: Spectral analysis of heart rate and arterial pressure variabilities is a powerful noninvasive tool that is increasingly used to infer alterations of cardiovascular autonomic regulation in a variety of physiological and pathophysiological conditions such as hypertension, myocardial infarction, and congestive heart failure. A most important methodological issue to properly interpret the results obtained by the spectral analysis of cardiovascular variability signals is represented by the attribution of neurophysiological correlates to these spectral components. In this regard, recent application of spectral techniques to the evaluation of the oscillatory properties of sympathetic efferent activity in animals as well as in humans offers a new approach to a better understanding of the relationship between cardiovascular oscillations and autonomic regulation. The data so far collected seem to suggest the presence of a centrally organized neural code, characterized by excitatory and inhibitory neural mechanisms subserving the genesis and the regulation of cardiovascular oscillations concerning the major variables of autonomic regulation.
authors.affiliation: Centro Ricerche Cardiovascolari, CNR, DiSP LITA di Vialba, Università degli Studi di Milano, Ospedale L. Sacco, Via G. B. Grassi 74, 20157 Milano, Italy. nicola.montano@unimi.it
authors.forename: N
authors.initials: N
authors.lastname: Montano
authors.forename: A
authors.initials: A
authors.lastname: Porta
authors.forename: A
authors.initials: A
authors.lastname: Malliani
mesh_terms: D000818:Animals; D017704:Baroreflex / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D002490:Central Nervous System / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D010507:Periodicity; D013564:Sympathetic Nervous System / Q000502:physiology