Strategies for mapping susceptibility genes in age-related maculopathy.
The prospects for mapping genes conferring susceptibility to common disorders such as age-related maculopathy have increased as a result of advances in high-throughput genotyping using single nucleotide polymorphisms. This should not obscure the magnitude of the task of identifying what are potentially a diverse group of genetic variants with small or intermediate effects on disease susceptibility. Strategies for increasing the odds of success in such an endeavour are discussed.
Wright
A F
AF
MRC Human Genetics Unit, Western General Hospital, Edinburgh, UK.
D016022:Case-Control Studies; D002874:Chromosome Mapping / Q000379:methods*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D008268:Macular Degeneration / Q000235:genetics*; D020641:Polymorphism, Single Nucleotide