Transcriptional reprogramming during T helper cell differentiation.
Our laboratory employs reporter transgenic mice as model systems to study the transcriptional reprogramming that accompanies T helper cell differentiation. These studies demonstrate that changes in the activity of simple transcriptional elements associated with the IFN-gamma gene can recapitulate alterations in gene expression. In addition, our studies have revealed a key role for the transcription factor, CAMP response element binding protein (CREB), in the protection of differentiating T cells from apoptosis. Together, these findings further our understanding of the logic employed by T cells to alter gene expression profiles in response to differentiation signals.
Aune
T M
TM
Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. thomas.aune@mcmail.vanderbilt.edu
D000818:Animals; D017209:Apoptosis; D001921:Brain / Q000502:physiology; D018414:CD8-Positive T-Lymphocytes / Q000378:metabolism; D002454:Cell Differentiation; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000502:physiology; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics / Q000502:physiology; D016572:Cyclosporine / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000037:antagonists & inhibitors; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D017930:Genes, Reporter; D007156:Immunologic Memory; D007166:Immunosuppressive Agents / Q000494:pharmacology; D007371:Interferon-gamma / Q000096:biosynthesis / Q000235:genetics; D018664:Interleukin-12 / Q000494:pharmacology / Q000502:physiology; D015847:Interleukin-4 / Q000096:biosynthesis / Q000235:genetics; D008568:Memory / Q000502:physiology; D051379:Mice; D008822:Mice, Transgenic; D023421:Models, Animal; D008954:Models, Biological; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D011401:Promoter Regions, Genetic / Q000187:drug effects; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D014157:Transcription Factors / Q000037:antagonists & inhibitors; D014158:Transcription, Genetic / Q000502:physiology*
D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D007166:Immunosuppressive Agents; D050778:NFATC Transcription Factors; D009687:Nuclear Proteins; D011948:Receptors, Antigen, T-Cell; D014157:Transcription Factors; D018664:Interleukin-12; D005576:Colforsin; D015847:Interleukin-4; D007371:Interferon-gamma; D016572:Cyclosporine; D000242:Cyclic AMP