Role of Toll-like receptors in inflammatory response in macrophages.
The innate immune response is the first line of defense against infectious disease. It is vital that the host detect the pathogen and rapidly mount a defense. The Toll-like family of receptors have evolved to detect conserved patterns on pathogens. When stimulated, these receptors activate the inflammatory response.
Aderem
A
A
Department of Immunology, University of Washington, Seattle 98195, USA. aderem@sytemsbiology.org
D001424:Bacterial Infections / Q000276:immunology*; D029721:Drosophila Proteins; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology*; D007249:Inflammation / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D008262:Macrophage Activation / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology; D051193:Toll-Like Receptors
D029721:Drosophila Proteins; D008070:Lipopolysaccharides; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D051193:Toll-Like Receptors