Fibrinogen polymorphisms and atherothrombotic disease.
Common polymorphisms of the fibrinogen gene cluster are associated with circulating fibrinogen level and with susceptibility to and/or severity of atherothrombotic disease. The frequencies of the polymorphisms vary among different ethnic groups but there is strong linkage disequilibrium at the beta-fibrinogen gene locus so that, in caucasian populations, there are only four common beta-fibrinogen haplotypes. One of these haplotypes, defined by the beta-fibrinogen -455A allele, is associated with elevated fibrinogen level and increased risk of atherothrombotic disease. The molecular mechanism of these associations is currently under investigation.
Green
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Department of Cardiovascular Medicine, University of Oxford, Wellcome Trust Centre for Human Genetics, Roosevelt Drive, Headington, Oxford, United Kingdom. fionag@well.ox.ac.uk
D001161:Arteriosclerosis / Q000235:genetics*; D005340:Fibrinogen / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D011110:Polymorphism, Genetic; D013927:Thrombosis / Q000235:genetics*
D005340:Fibrinogen