Fluticasone propionate and budesonide do not influence bone metabolism in the long term treatment of asthma.
BACKGROUND
Inhaled corticosteroids (ICS) are recommended in the treatment of asthmatic patients. They have been said to be efficacious in the treatment of asthma in respect to cortisol and bone metabolism.


METHODS
The effects of the two inhaled corticosteroid, budesonide (BUD) and fluticasone propionate (FP) on bone metabolism, morning cortisol and their effects on the clinical parameters (FEV1, diurnal variation of peak expiratory flow rate = PEFR and log PC20) were examined in a group of 16 asthmatic patients. Eight patients used 800 micrograms/daily BUD and 8,400 micrograms/daily FP during 6 months period.


RESULTS
Both BUD and FP improved clinical parameters as determined by FEV1 (p < 0.05) and PEFR (p < 0.01). There was no difference in respect to log PC20 values in either group (p > 0.05). Both treatments didn't change morning cortisol (p < 0.05). Both FP and BUD didn't change any indices of bone formation as determined by serum alkaline phosphatase, bone alkaline phosphatase, osteocalcin and carboxyterminal propeptide of type 1 procollagen and bone resorption as determined by urinary calcium and deoxypyridinoline (p > 0.05). In addition there was no significant effect on calcium and phosphate metabolism (serum calcium, phosphate and parathyroid hormone).


CONCLUSIONS
As a result, having no adverse effect on bone metabolism and adrenal function, in the regard to clinical efficacy, FP is as effective as the double dose of BUD on PEFR and FEV1.
Harmanci
E
E
Department of Pulmonary Diseases, Osmangazi University, Medical Faculty, Eskisehir, Turkey.
Colak
O
O
Metintas
M
M
Alatas
O
O
Yurdasiper
A
A
D000280:Administration, Inhalation; D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood; D000596:Amino Acids / Q000652:urine; D000730:Androstadienes / Q000008:administration & dosage / Q000009:adverse effects*; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D015415:Biomarkers / Q000097:blood; D001862:Bone Resorption / Q000097:blood / Q000139:chemically induced* / Q000652:urine; D001842:Bone and Bones / Q000187:drug effects*; D001985:Bronchial Provocation Tests; D019819:Budesonide / Q000008:administration & dosage / Q000009:adverse effects*; D002118:Calcium / Q000652:urine; D005260:Female; D000068298:Fluticasone; D005541:Forced Expiratory Volume / Q000187:drug effects; D006632:Histamine; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood; D010024:Osteoporosis / Q000139:chemically induced; D010281:Parathyroid Hormone / Q000097:blood; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D010710:Phosphates / Q000097:blood
D000596:Amino Acids; D000730:Androstadienes; D018927:Anti-Asthmatic Agents; D015415:Biomarkers; D010281:Parathyroid Hormone; D010710:Phosphates; D015675:Osteocalcin; D019819:Budesonide; D006632:Histamine; C036020:deoxypyridinoline; D000068298:Fluticasone; D000469:Alkaline Phosphatase; D002118:Calcium; D006854:Hydrocortisone