Cytoplasmic dynein subunit heterogeneity: implications for axonal transport.
The formation and maintenance of neuronal synapses is dependent on the active transport of material between the cell body and the axon terminal. Cytoplasmic dynein is one motor for microtubule-based axonal transport. Two pools of cytoplasmic dynein have been identified in the axon. They are distinguished by their intermediate and light intermediate chain subunits. Each pool is transported at different rates down the axon in association with different proteins or organelles. This review presents several models to discuss the potential functional roles of these different pools of cytoplasmic dynein during axonal transport.
Susalka
S J
SJ
Department of Cell Biology, School of Medicine, PO Box 800732, University of Virginia, Charlottesville, VA 22908, USA.
Pfister
K K
KK
D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D004398:Dyneins / Q000737:chemistry / Q000378:metabolism*; D046911:Macromolecular Substances; D008870:Microtubules / Q000378:metabolism; D008959:Models, Neurological; D020409:Molecular Motor Proteins / Q000378:metabolism; D016900:Neurofilament Proteins / Q000378:metabolism; D021122:Protein Subunits
D046911:Macromolecular Substances; D020409:Molecular Motor Proteins; D016900:Neurofilament Proteins; D021122:Protein Subunits; D004398:Dyneins