Induction of cytochromes P450.
Humans and rodents are exposed to many foreign compounds in their diet (e.g., herbal supplements such as St. John's wart), in their environment (e.g., organochlorine pesticides and polychorinated biphenyls), and as clinically prescribed drugs (e.g., rifampin and phenobarbital). In response to these exposures mammals have evolved mechanisms to induce proteins involved in xenobiotic detoxification. Metabolism by Phase I enzymes, particularly the heme containing monooxygenases cytochromes P450 is frequently the first line of defense against such xenobiotics.
Schuetz
E G
EG
St. Jude Children's Research Hospital, Dept. Pharmaceutical Sciences, Memphis, TN 38105, USA. erin.schuetz@stjude.org
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction; D006801:Humans; D008658:Inactivation, Metabolic; D051379:Mice; D018345:Mice, Knockout; D008862:Microsomes, Liver / Q000201:enzymology; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism; D013256:Steroids / Q000378:metabolism; D013379:Substrate Specificity; D015262:Xenobiotics / Q000378:metabolism
D018528:ATP-Binding Cassette Transporters; D001647:Bile Acids and Salts; D018160:Receptors, Cytoplasmic and Nuclear; D013256:Steroids; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System