title: Clinical and virological evaluation of the efficacy of an inactivated EHV1 and EHV4 whole virus vaccine (Duvaxyn EHV1,4). Vaccination/challenge experiments in foals and pregnant mares.
abstract: Pregnant mares and young foals were vaccinated with Duvaxyn EHV1,4, an inactivated and adjuvanted vaccine containing both the EHV-1 and 4 antigens. SN and CF antibody titres were induced two weeks after first vaccination. Antibody levels were boosted after second vaccination, however they never reached the levels induced after virus challenge. Young foals were challenged with virulent EHV-1 and EHV-4 field viruses. Pregnant mares were challenged with the highly abortigenic EHV-1 strain Ab4. Vaccinated animals showed a clear reduction in clinical signs and virus excretion compared to unvaccinated control animals. Log transformed antibody levels could be correlated to duration of virus excretion. The incidence of EHV-1 induced abortions was drastically reduced in vaccinated mares. Therefore, although vaccinated animals are not fully protected against disease, Duvaxyn EHV1,4 clearly reduces clinical symptoms, the duration of virus shedding and the quantity of virus shed. It can be concluded that vaccination of foals and pregnant mares with Duvaxyn EHV1,4 significantly reduces the risk of abortions and outbreaks of respiratory disease caused by circulating field viruses.
authors.affiliation: Fort Dodge Animal Health Holland, Department of Bio R&D, C.J. van Houtenlaan 36, 1381, CP Weesp, The Netherlands. jacco.heldens@intervet.com
authors.forename: J G
authors.initials: JG
authors.lastname: Heldens
authors.forename: D
authors.initials: D
authors.lastname: Hannant
authors.forename: A A
authors.initials: AA
authors.lastname: Cullinane
authors.forename: M J
authors.initials: MJ
authors.lastname: Prendergast
authors.forename: J A
authors.initials: JA
authors.lastname: Mumford
authors.forename: M
authors.initials: M
authors.lastname: Nelly
authors.forename: J H
authors.initials: JH
authors.lastname: Kydd
authors.forename: M W
authors.initials: MW
authors.lastname: Weststrate
authors.forename: R
authors.initials: R
authors.lastname: van den Hoven
mesh_terms: D000034:Abortion, Veterinary / Q000517:prevention & control; D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D005334:Fever / Q000209:etiology; D006566:Herpesviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D004861:Herpesvirus 1, Equid / Q000276:immunology* / Q000302:isolation & purification; D023141:Herpesvirus 4, Equid / Q000276:immunology* / Q000302:isolation & purification; D006734:Horse Diseases / Q000517:prevention & control*; D006736:Horses; D009305:Nasopharynx / Q000821:virology; D011247:Pregnancy; D014611:Vaccination / Q000662:veterinary*; D015164:Vaccines, Inactivated / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology*; D014766:Viremia / Q000821:virology
chemical_list: D000914:Antibodies, Viral; D015164:Vaccines, Inactivated; D014765:Viral Vaccines