Protein export and drug efflux through bacterial channel-tunnels.
The bacterial protein TolC assembles into an alpha-helical trans-periplasmic tunnel, which is embedded in the outer membrane by a contiguous beta-barrel channel. TolC and its homologues thus provide large exit ducts for a wide range of substrates, including protein toxins and antibacterial drugs, that are engaged by specific recognition proteins in the cytosolic membrane.
Andersen
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Cambridge University Department of Pathology, Tennis Court Road, CB2 1QP, Cambridge, UK.
Hughes
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Koronakis
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D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D017124:Conserved Sequence; D004352:Drug Resistance, Microbial; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D008954:Models, Biological; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D021381:Protein Transport
D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; C073126:tolC protein, E coli