title: Channeling agent and drug release from a central core matrix tablet.
abstract: A new oral dosage form for controlled and complete release of drug after a predetermined lag time is described. The system, designed to exploit the relatively constant small intestine transit time, consists of a drug-containing core coated with a polymeric matrix formed by a channeling agent (NaCl, mannitol, and Emdex) and an inert polymer (Eudragit RS100). The lag time was found to be dependent on type and particle size of the channeling substances used. Also, rheological properties of the binary mixtures (channeling substance--polymer) can affect the lag time periods. On the other hand, the release kinetics were found to be influenced significantly by excipient type and particle size. Results obtained from in vitro dissolution testing demonstrated that this device potentially could be used to deliver drugs orally for up to once-a-day dosing at controllable rates.
authors.affiliation: Departamento de Farmacia y Tecnología Farmacéutica, Universidad de Sevilla, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: González-Rodríguez
authors.forename: J I
authors.initials: JI
authors.lastname: Pérez-Martínez
authors.forename: S
authors.initials: S
authors.lastname: Merino
authors.forename: A
authors.initials: A
authors.lastname: Fini
authors.forename: A M
authors.initials: AM
authors.lastname: Rabasco
mesh_terms: D000284:Administration, Oral; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems; D005079:Excipients / Q000737:chemistry*; D006801:Humans; D007473:Ion Channels; D008353:Mannitol / Q000008:administration & dosage; D008751:Methylene Blue / Q000737:chemistry*; D009930:Organic Chemicals; D010316:Particle Size; D011108:Polymers; D012212:Rheology; D012965:Sodium Chloride / Q000737:chemistry*; D012995:Solubility; D013607:Tablets; D013997:Time Factors
chemical_list: D003692:Delayed-Action Preparations; D005079:Excipients; D007473:Ion Channels; D009930:Organic Chemicals; D011108:Polymers; D013607:Tablets; D008353:Mannitol; D012965:Sodium Chloride; C038962:EMDEX; D008751:Methylene Blue