Review of statistical methods for QTL mapping in experimental crosses.
Identification of quantitative trait loci (QTLs) in experimental animals is critical for understanding the biochemical bases of complex traits, and thus for the identification of drug targets. The author reviews the basic statistical methods for mapping QTLs in experimental crosses and comments on a number of the statistical issues to consider in the application of these methods.
Broman
K W
KW
Department of Biostatistics, Johns Hopkins University, 615 N. Wolfe St., Baltimore, MD 21205, USA. kbroman@jhsph.edu
D000818:Animals; D001947:Breeding / Q000706:statistics & numerical data*; D002874:Chromosome Mapping / Q000706:statistics & numerical data*; D003433:Crosses, Genetic; D005819:Genetic Markers; D005838:Genotype; D008432:Mathematical Computing; D051379:Mice; D008957:Models, Genetic; D010641:Phenotype
D005819:Genetic Markers