External standard method for the in vivo quantification of choline-containing compounds in breast tumors by proton MR spectroscopy at 1.5 Tesla.
Quantification of choline-containing compounds observed with (1)H MRS of breast tumors is of interest since such compounds have been linked to malignancy. Experiments were performed at 1.5 T with an external standard containing phosphocholine for calibration. In phantom studies, good precision was achieved after correction for T(1)/T(2) effects. T(2) values for choline were estimated for two breast cancer patients. A choline concentration of 2.0 mM was calculated for a third patient, a result comparable to in vitro findings. Magn Reson Med 46:189-192, 2001.
Bakken
I J
IJ
SINTEF Unimed, MR Center, N-7465 Trondheim, Norway. Inger.Bakken@unimed.sintef.no
Gribbestad
I S
IS
Singstad
T E
TE
Kvistad
K A
KA
D001943:Breast Neoplasms / Q000378:metabolism*; D002794:Choline / Q000032:analysis*; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D019047:Phantoms, Imaging
D002794:Choline