title: Can [15O]water be used to evaluate drugs?
abstract: There is an extensive literature supporting the use of rCBF as a surrogate marker of local neuronal activity. This provides a strong physiologic rationale for using PET measurements of rCBF to study the effects of drugs acting on the brain. The ability to perform multiple brief measurements of rCBF with [15O]water in a single study session makes possible a wide variety of experimental designs. Numerous investigators have successfully applied the method to study a wide variety of centrally acting drugs. In summary, then, the answer to the question, "Can [15O]water be used to evaluate drugs?" is a definitive yes.
authors.affiliation: PET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
authors.forename: P
authors.initials: P
authors.lastname: Herscovitch
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D001923:Brain Chemistry; D004341:Drug Evaluation / Q000379:methods*; D006801:Humans; D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed; D014867:Water / Q000378:metabolism
chemical_list: D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D014867:Water