Characterisation of portal hypertension models by microspheres in anaesthetised rats: a comparison of liver flow.
Several portal hypertensive animal models are available and frequently used for haemodynamic studies. The portal venous inflows, measured with microspheres in pentobarbital anaesthetised rats, are compared here. The partial portal vein ligation model is characterised by a high portal venous inflow, together with extensive portal systemic shunting, at the cost of portal sinusoidal flow. In carbon tetrachloride-induced micronodular cirrhosis, portal sinusoidal flow, which reaches liver parenchyma, is high, and this is more pronounced in the presence of ascites. In bile duct ligation and excision-induced cirrhosis, an increase in liver weight was not equally followed by an increase in portal sinusoidal flow, pointing to a relatively underperfused liver.
Van de Casteele
M
M
Institute of Clinical Pharmacology, University of Berne, Murtenstrasse 35, CH-3010 Berne, Switzerland. marc.vandecasteele@med.kuleuven.ac.be
Sägesser
H
H
Zimmermann
H
H
Reichen
J
J
D000818:Animals; D001201:Ascites; D001652:Bile Ducts / Q000601:surgery; D001783:Blood Flow Velocity; D002251:Carbon Tetrachloride; D004195:Disease Models, Animal; D006439:Hemodynamics; D006975:Hypertension, Portal / Q000150:complications / Q000503:physiopathology*; D008099:Liver / Q000098:blood supply* / Q000473:pathology; D008103:Liver Cirrhosis / Q000209:etiology / Q000503:physiopathology*; D008863:Microspheres; D010424:Pentobarbital; D011169:Portal Vein; D051381:Rats
D002251:Carbon Tetrachloride; D010424:Pentobarbital