title: Leiomyosarcoma of the female breast.
abstract: Leiomyosarcomas of the breast are rare tumors. Less than 15 such cases have been reported in the literature so far. In this paper authors describe a case of leiomyosarcoma of a female breast presenting as a firm lobulated mass, mimicking a phylloid tumor radiographically. By fine needle aspiration biopsy, on the smears discohesive malignant looking cells were conclusive to a poorly differentiated invasive ductal carcinoma of the breast. The mastectomy specimen contained a lobulated mass, microscopically showing a partly epithelioid spindle cell tumor, immunoreactive for vimentin, desmin, smooth muscle actin antibodies, and negative for epithelial markers, hormone and growth factor receptors. Axillary lymph nodes were free of tumor. A primary leiomyosarcoma of the breast was diagnosed.
authors.affiliation: Semmelweis University, 2nd Department of Pathology Ullôi út 93, Budapest, H-1091, Hungary. szesz@korb2.sote.hu
authors.forename: E
authors.initials: E
authors.lastname: Székely
authors.forename: L
authors.initials: L
authors.lastname: Madaras
authors.forename: J
authors.initials: J
authors.lastname: Kulka
authors.forename: B
authors.initials: B
authors.lastname: Járay
authors.forename: L
authors.initials: L
authors.lastname: Nagy
mesh_terms: D000199:Actins / Q000032:analysis; D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D001943:Breast Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis; D003893:Desmin / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007890:Leiomyosarcoma / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D009363:Neoplasm Proteins / Q000032:analysis; D003557:Phyllodes Tumor / Q000175:diagnosis; D014746:Vimentin / Q000032:analysis
chemical_list: D000199:Actins; D014408:Biomarkers, Tumor; D003893:Desmin; D009363:Neoplasm Proteins; D014746:Vimentin