title: Increased oxidative stress in childhood atopic dermatitis.
abstract: Atopic dermatitis (AD) is a chronic inflammatory skin disease of unknown etiology. To examine the involvement of impaired homeostasis of oxygen/nitrogen radicals in childhood AD, we compared the levels of urinary 8-hydroxy-2'-deoxyguanosine (marker of oxidative stress), nitrite/nitrate (marker of nitric oxide synthesis) and selenium (marker of selenium store) in 27 children with AD to those of 25 healthy control children. Urinary 8-hydroxy-2'-deoxyguanosine was significantly higher and nitrite/nitrate levels were significantly lower in patients with AD than in the control. Urinary selenium levels were similar in both groups. Our findings suggest that impaired homeostasis of oxygen/nitrogen radicals and increased oxidative stress are involved in the pathophysiology of childhood AD, and indicate that suppression of oxidative stress might be a potentially useful strategy for the treatment of AD.
authors.affiliation: Department of Pediatrics, Fukui Medical University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Omata
authors.forename: H
authors.initials: H
authors.lastname: Tsukahara
authors.forename: S
authors.initials: S
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Ohshima
authors.forename: M
authors.initials: M
authors.lastname: Yasutomi
authors.forename: A
authors.initials: A
authors.lastname: Yamada
authors.forename: M
authors.initials: M
authors.lastname: Jiang
authors.forename: M
authors.initials: M
authors.lastname: Hiraoka
authors.forename: M
authors.initials: M
authors.lastname: Nambu
authors.forename: Y
authors.initials: Y
authors.lastname: Deguchi
authors.forename: M
authors.initials: M
authors.lastname: Mayumi
mesh_terms: D000080242:8-Hydroxy-2'-Deoxyguanosine; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003849:Deoxyguanosine / Q000031:analogs & derivatives / Q000652:urine*; D003876:Dermatitis, Atopic / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006706:Homeostasis; D006801:Humans; D008297:Male; D009566:Nitrates / Q000652:urine; D009573:Nitrites / Q000652:urine; D018384:Oxidative Stress; D012643:Selenium / Q000652:urine
chemical_list: D009566:Nitrates; D009573:Nitrites; D000080242:8-Hydroxy-2'-Deoxyguanosine; D003849:Deoxyguanosine; D012643:Selenium