title: Ibuprofen to rofecoxib: what does it all mean and what do I do now?
abstract: NSAIDs are used throughout the World Health Organization three-step analgesic ladder, and are indicated for pain in all stages of malignancy. Side-effects are common with NSAIDs. Much has been written about NSAIDs and COX, since the discovery of COX-1 and COX-2 isoforms. How do you choose the appropriate NSAID? The choice of NSAID continues to be dependent upon associated gastroduodenal toxicity and the related risk factors of individual patients. Choosing the appropriate NSAID should minimize the likelihood of needing additional medications to manage adverse effects and symptoms caused by the NSAID therapy itself.
authors.affiliation: Pain and Palliative Care Association, Orlando, Florida, USA.
authors.forename: J
authors.initials: J
authors.lastname: Varga
authors.forename: A
authors.initials: A
authors.lastname: Dickman
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D016527:Drug Costs; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007052:Ibuprofen / Q000009:adverse effects / Q000145:classification / Q000191:economics / Q000627:therapeutic use*; D007783:Lactones / Q000145:classification / Q000191:economics / Q000627:therapeutic use*; D009369:Neoplasms / Q000150:complications; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D018579:Patient Selection; D012307:Risk Factors; D013450:Sulfones; D013727:Terminal Care / Q000379:methods
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007783:Lactones; D013450:Sulfones; C116926:rofecoxib; D007052:Ibuprofen