Timing and localization of movement-related spectral changes in the human peri-Rolandic cortex: intracranial recordings.
Event-related spectral power (ERSP) was measured from intracranial EEG and used to characterize the time-course and localization of the Rolandic mu rhythms in 12 patients during the delayed recognition of words or faces (DR) and the discrimination of simple lateralized visual targets (LVD). On each trial, the subject decided whether to make manual response (Go) or not (NoGo). ERSP increased on both Go and NoGo trials in peri-Rolandic regions of all subjects with a peak latency of approximately 330-ms poststimulus and duration of 260 ms during the DR task. The peak of this ERSP increase preceded movement by approximately 300 ms. All subjects produced a subsequent movement specific ERSP decrease of peri-Rolandic mu rhythms (starting approximately 90 ms before the average reaction time) with an peak latency of approximately 800 ms and duration of approximately 520 ms. The LVD task produced bilateral movement-selective readiness potentials and reproduced the movement-specific late ERSP decreases seen in the DR task (strongest from 7-24 Hz). Furthermore, the LVD task demonstrated that the late movement-related ERSP decrease is larger for the contralateral hand. However, the LVD task did not consistently reproduce the early ERSP increase seen in the DR task. Movement-related ERSP decreases were widespread, occurring in pre- and post-Rolandic as well as primary-motor, supplemental motor, and cingulate cortical regions. Other cortical areas including frontal, temporal, and occipital regions did not show movement-related ERSP changes. Peri-Rolandic ERSP decreases in mu rhythms correlate with the generation of a motor command. The early increases in mu may reflect a transient state of motor inhibition just prior to motor execution.
Klopp
J
J
Brain Monitoring and Modeling Laboratory, Brain Research Institute, UCLA, Los Angeles, California, USA.
Marinkovic
K
K
Clarke
J
J
Chauvel
P
P
Nenov
V
V
Halgren
E
E
D001931:Brain Mapping; D002540:Cerebral Cortex / Q000503:physiopathology*; D004292:Dominance, Cerebral / Q000502:physiology; D004567:Electrodes, Implanted; D004569:Electroencephalography; D017029:Epilepsy, Complex Partial / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D005071:Evoked Potentials / Q000502:physiology; D005583:Fourier Analysis; D006801:Humans; D011939:Mental Recall / Q000502:physiology*; D009044:Motor Cortex / Q000503:physiopathology; D009433:Neural Inhibition / Q000502:physiology; D010364:Pattern Recognition, Visual / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology*; D012815:Signal Processing, Computer-Assisted