title: Are proinflammatory cytokine concentrations reduced by plasma exchange in patients with severe acute hepatic failure?
abstract: We studied citric acid levels and proinflammatory cytokines (TNF-alpha, IL-6, and IL-8) before and after plasma exchange in 8 patients with acute liver failure. Plasma exchange was performed over a 6 to 7-hour period. At each session, 3.6 to 4.0 1 of plasma was exchanged for the same volume of fresh frozen plasma (FFP). The concentrations of citric acid were significantly increased after plasma exchange above concentrations before exchange (p<0.0001). There were no significant differences in TNF-alpha, IL-6, or IL-8 concentrations (p=0.7222, p=0.9357, p=0.6394, respectively). Thus, plasma exchange with FFP alone may not effectively remove cytokines.
authors.affiliation: Department of Emergency and Critical Care Medicine, Akita University School of Medicine, Hondo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakae
authors.forename: T
authors.initials: T
authors.lastname: Yonekawa
authors.forename: K
authors.initials: K
authors.lastname: Narita
authors.forename: S
authors.initials: S
authors.lastname: Endo
mesh_terms: D000328:Adult; D000368:Aged; D019343:Citric Acid / Q000097:blood; D016207:Cytokines / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D017114:Liver Failure, Acute / Q000378:metabolism* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010951:Plasma Exchange; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D019343:Citric Acid