Cell migration in invertebrates: clues from border and distal tip cells.
Recent studies in two invertebrate systems, border cells in Drosophila melanogaster and distal tip cells in Caenorhabditis elegans, have provided important insight into the mechanisms of directed cell migration. These migrating cells are guided by extracellular signals, such as EGF, TGF-beta and netrin. In addition, metalloproteases alter the extracellular matrix of the tissue through which these cells migrate. Along the migratory path, migrating cells respond to changes in guidance signals by altering the expression of receptor signaling pathways. Finally, Dock180, CrkII and the GTPase Rac link the extracellular signals to the cellular machinery that controls cell motility.
Lehmann
R
R
Developmental Genetics Program, Skirball Institute and Howard Hughes Medical Institute, Department of Cell Biology, New York University Medical School, 540 First Avenue, New York 10016, New York, USA. lehmann@saturn.med.nyu.edu
D000818:Animals; D017173:Caenorhabditis elegans / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D002465:Cell Movement / Q000502:physiology*; D004331:Drosophila melanogaster / Q000166:cytology / Q000378:metabolism / Q000502:physiology; D007448:Invertebrates; D015398:Signal Transduction / Q000502:physiology*