Immune responses in bovine tuberculosis.
Knowledge of the immune responses which develop in cattle following infection with Mycobacterium bovis is essential both to the understanding of disease pathogenesis and to the logical development of immune-dependent tools, such as diagnostic tests and vaccines, which can be used to combat the disease. Studies of field cases of bovine tuberculosis (TB) and of experimental bovine models of M. bovis infection have indicated that cell-mediated immune responses (CMI) predominate within a spectrum of immunity which exists. This paper reviews aspects of recent research and indicates how knowledge of T-cell antigenic targets in bovine TB along with increasing knowledge of T-cell subpopulations and their interactions with M. bovis -infected macrophages provides opportunities for the development of better methods for disease control.
Pollock
J M
JM
Veterinary Sciences Division, Department of Agriculture and Rural Development, Stoney Road, Stormont, Belfast, BT4 3SD, UK.
McNair
J
J
Welsh
M D
MD
Girvin
R M
RM
Kennedy
H E
HE
Mackie
D P
DP
Neill
S D
SD
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001500:BCG Vaccine; D016516:CD4-CD8 Ratio; D002417:Cattle; D007111:Immunity, Cellular / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D016176:T-Lymphocyte Subsets / Q000276:immunology; D014380:Tuberculosis, Bovine / Q000175:diagnosis / Q000276:immunology*
D000942:Antigens, Bacterial; D001500:BCG Vaccine; D007371:Interferon-gamma