Partial irradiation of the liver.
The use of three-dimensional radiotherapy (RT) and the prospective follow-up of patients for radiation-induced liver disease (RILD) have led to a more quantitative understanding of the partial organ tolerance of the liver compared with previous estimates based on clinical judgment alone. Parameters of both the Lyman normal tissue complication probability (NTCP) model and a local damage-organ injury (D-I) NTCP model have been fit to clinical data from patients who have received hepatic radiation. Based on analyses of over 180 patients, the liver exhibits a large volume effect and a low threshold volume for RILD. Mean liver dose is associated with RILD, and no cases of RILD have been reported in patients with a mean liver dose of less than 31 Gy. Most recent estimates of the partial liver tolerance to RT suggest that if less than 25% of the normal liver is treated with RT, then there may be no upper limit on dose associated with RILD. Estimates of the liver doses associated with a 5% risk of RILD for uniform irradiation of one third, two thirds, and the whole liver are 90 Gy, 47 Gy, and 31 Gy, respectively.
Dawson
L A
LA
Department of Radiation Oncology, University of Michigan, 1500 E. Medical Center Dr., Ann Arbor, MI 48109-0010, USA. dawson@umich.edu
Ten Haken
R K
RK
Lawrence
T S
TS
D056486:Chemical and Drug Induced Liver Injury; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008099:Liver / Q000528:radiation effects*; D008107:Liver Diseases / Q000532:radiotherapy*; D008113:Liver Neoplasms / Q000532:radiotherapy*; D011836:Radiation Tolerance