title: [Analysis of psoriasis susceptibility regions in the Spanish population: evidence of a major gene involved in psoriasis in the 6p21 region].
abstract: BACKGROUND
  Identification of the susceptibility regions to psoriasis in Spanish population. Analysis of the chromosomal regions 6p, 17q, 4q and 1cen-q21.
  
  
  METHODS
  Analysis of 27 Spanish families with psoriasis. Parametric and non-parametric linkage analysis with 22 polymorphic microsatellite markers in the candidate regions.
  
  
  RESULTS
  Evidence of linkage (p < 0,05) using non-parametric methods in chromosome 6p. Absence of linkage in 17q, 4q and 1cen-q21 regions.
  
  
  CONCLUSIONS
  We present the evidence of a major gene in 6p21.3 involved in psoriasis in Spanish population.
authors.affiliation: Centre de Genètica Mèdica i Molecular, Institut de Recerca Oncològica, L'Hospitalet de Llobregat, Barcelona.
authors.forename: R
authors.initials: R
authors.lastname: de Cid
authors.forename: V
authors.initials: V
authors.lastname: Volpini
authors.forename: L
authors.initials: L
authors.lastname: Almasy
authors.forename: D
authors.initials: D
authors.lastname: Otero
authors.forename: X
authors.initials: X
authors.lastname: Estivil
authors.forename: C
authors.initials: C
authors.lastname: Lázaro
mesh_terms: D000328:Adult; D015984:Causality; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D010375:Pedigree; D011565:Psoriasis / Q000235:genetics*; D013030:Spain