title: Repetitive mucosal trauma promotes colon cancer in experimental rat model.
abstract: OBJECTIVE
  To investigate the effect of repetitive mucosal trauma, anastomosis and intestinal content on experimental colonic carcinogenesis as there is the possibility than non-specific colon lesions can promote cancer.
  
  
  METHODS
  We performed to sixty female Sprague-Dawley rats a 4 cm colon loop defunctionalization with double colostomy (traumatic site). Intestinal continuity was restored with an end-to-end colo-colic silk anastomosis. The surviving 47 rats were divided in 3 groups: Group A: 27 rats treated with DMH. Group B: 10 rats treated with EDTA and Group C: Control of 10 rats. Animals were sacrificed 31-32 weeks after surgery for macro and micropathological studies.
  
  
  RESULTS
  In group A appeared 60 tumours: 44 in the functional colon, 20 of them in the anastomotic site; 8 in the non traumatised defunctionalized segment and 18 in the traumatised segment (p < 0.05).
  
  
  CONCLUSIONS
  a) Continuous microtraumas on colonic mucosa in rats are cancer promotional factors; b) silk suture in anastomosis promotes cancer.
authors.affiliation: Departments of Medicine and Surgery, Lleida University School of Medicine, Arnau de Vilanova University Hospital, Lleida, Spain. jvinyes@arnau.scs.es
authors.forename: J
authors.initials: J
authors.lastname: Viñas Salas
authors.forename: C
authors.initials: C
authors.lastname: Piñol Felis
authors.forename: A
authors.initials: A
authors.lastname: Fermiñan
authors.forename: R
authors.initials: R
authors.lastname: Egido
authors.forename: S
authors.initials: S
authors.lastname: Pérez-Holanda
authors.forename: P
authors.initials: P
authors.lastname: Biendicho
authors.forename: J
authors.initials: J
authors.lastname: Buenestado
authors.forename: J
authors.initials: J
authors.lastname: Reñé Espinet
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D007413:Intestinal Mucosa / Q000293:injuries* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley