title: Elastic bounded diffusion and electron propagation: dynamics of the wiring of a self-assembly of immunoglobulins bearing terminally attached ferrocene poly(ethylene glycol) chains according to a spatially controlled organization.
abstract: Molecular monolayers of immunoglobulins bearing terminally attached ferrocene poly(ethylene glycol) chains (IgG-PEG-Fc) were self-assembled at an electrode surface in a step-by-step manner involving antigen-antibody recognition reactions. The total number N of assembled IgG-PEG-Fc monolayers and the number of spacers n(i) separating two successive IgG-PEG-Fc monolayers were controlled and varied. Electron transport through the protein assembly involves the dynamics of the terminally attached PEG chains and isotopic electron exchange between ferrocene heads belonging to successive IgG-PEG-Fc monolayers. The model of elastic bounded diffusion enabled us to analyze quantitatively the dependence of the rate of electron transport on N, n(i), and the rate constant (k(e)) of isotopic electron exchange. Wiring of a molecular monolayer of redox enzyme is also quantitatively characterized.
authors.affiliation: Laboratoire d'Electrochimie Moléculaire, Unité Mixte de Recherche Université--CNRS No 7591, Université de Paris 7--Denis Diderot, 2 place Jussieu, 75251 Paris Cedex 05, France.
authors.forename: A
authors.initials: A
authors.lastname: Anne
authors.forename: C
authors.initials: C
authors.lastname: Demaille
authors.forename: J
authors.initials: J
authors.lastname: Moiroux
mesh_terms: D000465:Algorithms; D004058:Diffusion; D004566:Electrodes; D004579:Electron Transport; D004800:Enzymes, Immobilized; D005296:Ferrous Compounds / Q000737:chemistry*; D005949:Glucose Oxidase / Q000737:chemistry; D007074:Immunoglobulin G / Q000737:chemistry*; D000075163:Metallocenes; D011092:Polyethylene Glycols / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D004800:Enzymes, Immobilized; D005296:Ferrous Compounds; D007074:Immunoglobulin G; D000075163:Metallocenes; D011092:Polyethylene Glycols; D005949:Glucose Oxidase; C004998:ferrocene