Anti-inflammatory activity of Pothomorphe peltata leaf methanol extract.
The methanol extract of Pothomorphe peltata leaves, orally administered at the dose of 20 mg/kg (equivalent to 2.50 g dry plant/kg) body weight, exhibited a significant anti-inflammatory activity, comparable with phenylbutazone (80 mg/kg, p.o.), against adjuvant-carrageenan-induced edema in rats.
Desmarchelier
C
C
I QUIMEFA-CONICET, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113), Buenos Aires, Argentina. cdesmar@ffyb.uba.ar
Slowing
K
K
Ciccia
G
G
D000284:Administration, Oral; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D006801:Humans; D019684:Magnoliopsida; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan; D010653:Phenylbutazone