Scavenging of fluorinated N,N'-dialkylureas by hydrogen binding: a novel separation method for fluorous synthesis.
[reaction: see text] A dramatic solubility increase in fluorous solvents is observed for N,N'-di(polyfluoroalkyl)ureas when hydrogen binding complexes are formed with commercially available perfluoroalkanoic acid scavengers. As a case example, analytically pure peptides and esters are obtained using this novel separation method.
Palomo
C
C
Departamento de Química Orgánica-I, Universidad del País Vasco, Facultad de Química, Apdo 1072, 20080 San Sebastián, Spain. qppaiipj@sc.ehu.es
Aizpurua
J M
JM
Loinaz
I
I
Fernandez-Berridi
M J
MJ
Irusta
L
L
D004952:Esters / Q000302:isolation & purification; D005466:Fluorocarbons / Q000737:chemistry*; D010455:Peptides / Q000302:isolation & purification*; D014508:Urea / Q000031:analogs & derivatives*
D004952:Esters; D005466:Fluorocarbons; D010455:Peptides; D014508:Urea