title: [Polymethylene derivatives of nucleic bases with omega-functional groups. II. Adenine and hypoxanthine derivatives].
abstract: N9-Polymethylene derivatives of adenine and hypoxanthine with various functional groups in the omega-position of the alkyl substituent were synthesized. Their physico-chemical properties and effect on the HIV reverse transcriptase and DNA topoisomerase I were studied.
authors.affiliation: Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, GSP-1 Moscow, 119991 Russia.
authors.forename: A A
authors.initials: AA
authors.lastname: Makinskiĭ
authors.forename: A M
authors.initials: AM
authors.lastname: Kritsyn
authors.forename: E A
authors.initials: EA
authors.lastname: Ul'ianova
authors.forename: O D
authors.initials: OD
authors.lastname: Zakharova
authors.forename: D V
authors.initials: DV
authors.lastname: Bugreev
authors.forename: G A
authors.initials: GA
authors.lastname: Nevinskiĭ
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000478:Alkylation; D004264:DNA Topoisomerases, Type I / Q000187:drug effects; D054303:HIV Reverse Transcriptase / Q000187:drug effects; D006838:Hydrocarbons; D019271:Hypoxanthine / Q000138:chemical synthesis / Q000494:pharmacology; D007042:Hypoxanthines; D008697:Methane / Q000031:analogs & derivatives*
chemical_list: D006838:Hydrocarbons; D007042:Hypoxanthines; C030011:carbene; D019271:Hypoxanthine; D054303:HIV Reverse Transcriptase; D004264:DNA Topoisomerases, Type I; D000225:Adenine; D008697:Methane