Vascular tissue engineering.
The development of a tissue-engineered blood vessel substitute has motivated much of the research in the area of cardiovascular tissue engineering over the past 20 years. Several methodologies have emerged for constructing blood vessel replacements with biological functionality. These include cell-seeded collagen gels, cell-seeded biodegradable synthetic polymer scaffolds, cell self-assembly, and acellular techniques. This review details the most recent developments, with a focus on core technologies and construct development. Specific examples are discussed to illustrate both the benefits and shortcomings of each methodology, as well as to underline common themes. Finally, a brief perspective on challenges for the future is presented.
Nerem
R M
RM
Georgia Tech/Emory Center for the Engineering of Living Tissues, Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332-0363, USA. robert.nerem@ibb.gatech.edu
Seliktar
D
D
D000818:Animals; D001672:Biocompatible Materials; D001698:Biomedical Engineering / Q000379:methods* / Q000639:trends; D001808:Blood Vessels / Q000637:transplantation; D004730:Endothelium, Vascular; D006801:Humans; D009131:Muscle, Smooth, Vascular; D011474:Prosthesis Design
D001672:Biocompatible Materials