Synthesis and photodynamic action of diphenyl-2,3-dihydroxychlorin: a potential tumor photosensitizer.
The synthesis, photophysical properties of diphenyl-2,3-dihydroxychlorin (DPCOH) and its photocytotoxicity to tumor cells are described. DPCOH exhibits photodynamic activity in terms of type I and type II mechanisms under irradiation. The quantum yield of (1)O(2) in CHCl(3) is 0.7. For the photocytotoxicity to tumor cells, DPCOH proved to be 200 times more potent than HPD, and the dark toxicity is low (dark IC(90)>32 microg/mL).
Wang
T Y
TY
Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, 100080, Beijing, China.
Liu
H L
HL
Chen
J R
JR
Liu
F G
FG
Gu
Y
Y
Ma
J S
JS
D001713:Biphenyl Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*; D004578:Electron Spin Resonance Spectroscopy; D006801:Humans; D008029:Lighting; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D001713:Biphenyl Compounds; D017319:Photosensitizing Agents; D011166:Porphyrins; C435783:diphenyl-2,3-dihydroxychlorin; C006969:chlorin