title: Image-based biomimetic approach to reconstruction of the temporomandibular joint.
abstract: This article will present an image-based approach to the designing and manufacturing of biomimetic tissue engineered temporomandibular (TMJ) condylar prosthesis. Our vision of a tissue-engineered TMJ prosthesis utilizes a 3-D designed and manufactured biodegradable scaffold shaped similar to a condylar head and neck, i.e. a condylar-ramus unit (CRU). The fabricated CRU scaffold can be constructed with a specific intra-architectural design such that it will enhance the formation of tissue from implanted cells placed within its interstices. These biologic cues could influence scaffold-implanted mesenchymal stem cells (MSC) or bone marrow stromal cells (BMSC) to form a fibrocartilaginous joint surface, or cap, on top of a bony strut, similar to a costochondral rib graft (CCRG), which could be fixed to the mandibular ramus. This new approach to tissue engineering a TMJ would be advantageous because of its patient site-specific anatomical configuration as well as its potential ability to adapt to the loading forces placed on it during function.
authors.affiliation: Department of Oral and Maxillofacial Surgery, School of Dentistry, University of Michigan, Ann Arbor, Mich., USA. sefein@umich.edu
authors.forename: S E
authors.initials: SE
authors.lastname: Feinberg
authors.forename: S J
authors.initials: SJ
authors.lastname: Hollister
authors.forename: J W
authors.initials: JW
authors.lastname: Halloran
authors.forename: T M
authors.initials: TM
authors.lastname: Chu
authors.forename: P H
authors.initials: PH
authors.lastname: Krebsbach
mesh_terms: D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001698:Biomedical Engineering / Q000379:methods*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008422:Materials Testing; D008953:Models, Anatomic; D011474:Prosthesis Design; D013704:Temporomandibular Joint / Q000033:anatomy & histology / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials