Evaluation of T-cell receptor CD3+ gamma delta in gestational diabetes mellitus.
Few studies have shown a significant increase of CD3+ T-cell receptor (TCR) gamma delta in the early phases of type 1 diabetes. We wished to determine if CD3+ TCR gamma delta is involved in the pathogenesis of gestational diabetes mellitus (GDM). We studied 29 GDM patients and 21 normal pregnant women. Lymphocyte subpopulations (CD3+ TCR alpha beta, CD3+ TCR gamma delta), islet cell antibodies (ICA), glutamic acid decarboxylase antibodies (GAD) and protein tyrosine phosphatase antibodies (IA2-Ab) were evaluated in all patients. The percentage of CD3+ TCR gamma delta was significantly higher in GDM women than in the control group (5.1 +/- 2.9% vs 3.7 +/- 1.7%; p < 0.05). No abnormalities of the other lymphocyte subpopulations were found. All subjects were negative for ICA; 2 GDM patients were positive for GAD, but no relationship was found between GAD positivity and CD3+ gamma delta levels in these 2 patients. Further follow-up studies of these patients are required to verify if the CD3+ TCR gamma delta receptor is a useful marker for diabetes development.
Lapolla
A
A
Section of Metabolic Disorders, Department of Medical and Surgical Sciences, Geriatric Hospital, University of Padua, Via Vendramini 7, I-35137 Padua, Italy.
Sanzari
M
M
Betterle
C
C
Dalfrà
M G
MG
Masin
M
M
Zanchetta
R
R
Zancanaro
F
F
Capovilla
F
F
Toniato
R
R
Plebani
M
M
Fedele
D
D
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D016640:Diabetes, Gestational / Q000097:blood / Q000276:immunology*; D005260:Female; D019270:Fructosamine / Q000097:blood; D005968:Glutamate Decarboxylase / Q000276:immunology; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology; D011247:Pregnancy / Q000097:blood / Q000276:immunology*; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases / Q000276:immunology; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000097:blood*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000097:blood; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000097:blood*; D012016:Reference Values; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D001323:Autoantibodies; D015415:Biomarkers; D001786:Blood Glucose; D019270:Fructosamine; D005968:Glutamate Decarboxylase; D006442:Glycated Hemoglobin; D054562:Protein Tyrosine Phosphatase, Non-Receptor Type 1; D017027:Protein Tyrosine Phosphatases; D017260:Receptor-CD3 Complex, Antigen, T-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; C024211:islet cell antibody