[Physical exercise and insulin sensitivity].
Physical exercise is known to be essential in the treatment of type 2 diabetes. An increased glucose uptake is evidenced during acute muscular exercise, over the post-exercise period, and following physical training. In this paper, we review metabolic and molecular aspects of physical exercise. We emphasize on the non-insulin dependent glucose transport induced by muscular contraction, which involves AMP-activated protein kinase. The discovery of this pathway is likely to open new therapeutic targets for type 2 diabetes.
Gautier
J F
JF
Service de Diabétologie, Hôpital Saint-Louis, Paris, France. j-fgautier@wanadoo.fr
Mauvais-Jarvis
F
F
D001692:Biological Transport; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000628:therapy*; D015444:Exercise / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D051272:Glucose Transporter Type 1; D051275:Glucose Transporter Type 4; D006801:Humans; D007333:Insulin Resistance; D009004:Monosaccharide Transport Proteins / Q000235:genetics / Q000378:metabolism; D009119:Muscle Contraction; D009124:Muscle Proteins; D018482:Muscle, Skeletal / Q000378:metabolism
D051272:Glucose Transporter Type 1; D051275:Glucose Transporter Type 4; D009004:Monosaccharide Transport Proteins; D009124:Muscle Proteins; C495677:SLC2A1 protein, human; C495692:SLC2A4 protein, human; D017868:Cyclic AMP-Dependent Protein Kinases; D005947:Glucose