[Biosynthes of polyketide antibiotics by various actinomycin producing Streptomyces species].
A collection of actinomycin-producing Streptomyces strains, their variants with different levels of antibiotic biosynthesis, and recombinant strains were screened in order to select new strains that produce polyketide antibiotics. Screening with the use of the cloned act gene encoding a component of actinorhodin polyketide synthase (PKS) multienzyme complex from Streptomyces coelicolor revealed that many strains tested can synthesize polyketide antibiotics along with actinomycins. A relationship between biosynthetic pathways of actinomycins and polyketides is discussed.
Alekhova
T A
TA
Moscow State University, Vorob'evy gory, Moscow, 119899 Russia.
Novozhilova
T Iu
TIu
D000217:Acyltransferases / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins; D015373:Bacterial Typing Techniques; D003609:Dactinomycin / Q000096:biosynthesis; D024881:Drug Resistance, Bacterial; D048630:Polyketide Synthases; D011995:Recombination, Genetic; D013302:Streptomyces / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D003609:Dactinomycin; D048630:Polyketide Synthases; D000217:Acyltransferases; C087193:polyketide beta-ketoacylsynthase