Invertebrate myogenesis: looking back to the future of muscle development.
Recent studies in invertebrates have provided important mechanistic insights into several general aspects of muscle development. Two new genes have been identified that are involved in muscle fusion in Drosophila and a novel maternal component was shown to be responsible for myogenic determination in an ascidian. In addition, genetic analyses of nematode and Drosophila homologues of factors known to be myogenic regulators in other species yielded surprising findings about both the evolutionary conservation and divergence of these functions. Drosophila myogenesis has become a highly informative model for understanding the interplay between the signaling and transcriptional networks that underlie cell-fate specification during embryonic development.
Baylies
M K
MK
Molecular Biology Program, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, 10021, New York, NY, USA. m-baylies@ski.mskcc.org
Michelson
A M
AM
D000818:Animals; D017173:Caenorhabditis elegans / Q000196:embryology / Q000235:genetics; D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins / Q000235:genetics; D002459:Cell Fusion; D004268:DNA-Binding Proteins / Q000235:genetics; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics; D004527:Egg Proteins / Q000235:genetics; D015870:Gene Expression; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D007448:Invertebrates; D064326:MEF2 Transcription Factors; D018485:Muscle Fibers, Skeletal; D009132:Muscles / Q000196:embryology*; D017570:MyoD Protein / Q000235:genetics; D018006:Myogenic Regulatory Factors; D009687:Nuclear Proteins / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D051879:Twist-Related Protein 1; D014561:Urochordata / Q000235:genetics
D029742:Caenorhabditis elegans Proteins; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D004527:Egg Proteins; C497752:HLH-8 protein, C elegans; D047908:Intracellular Signaling Peptides and Proteins; D064326:MEF2 Transcription Factors; C499409:Mef2 protein, Drosophila; D017570:MyoD Protein; D018006:Myogenic Regulatory Factors; D009687:Nuclear Proteins; C103173:TWIST1 protein, human; D014157:Transcription Factors; D051879:Twist-Related Protein 1; C420970:macho-1 protein, Halocynthia roretzi