title: Milk basic protein promotes bone formation and suppresses bone resorption in healthy adult men.
abstract: Milk contains several components effective for bone health. In the previous in vitro and in vivo studies, we have shown that milk whey protein, especially its basic protein fraction (milk basic protein [MBP]), promoted bone formation and suppressed bone resorption. This present study examines the effect of MBP on the biochemical markers of bone metabolism in healthy adult men. Experimental beverages containing MBP (300 mg of MBP a day) were given to 30 normal healthy adult men for 16 days. The serum osteocalcin concentration had increased significantly after 16 days of ingesting the experimental beverage containing MBP. Urinary cross-linked N-teleopeptides of type-I collagen (NTx) excretion had decreased significantly after 16 days of ingesting MBP. The urinary NTx excretion was related to the serum osteocalcin concentration after 16 days of ingestion. These results suggest that MBP promoted bone formation and suppressed bone resorption, while maintaining the balance of bone remodeling.
authors.affiliation: Technology and Research Institute, Snow Brand Milk Products Co. Ltd., Kawagoe, Saitama, Japan. yasutoba@aol.com
authors.forename: Y
authors.initials: Y
authors.lastname: Toba
authors.forename: Y
authors.initials: Y
authors.lastname: Takada
authors.forename: Y
authors.initials: Y
authors.lastname: Matsuoka
authors.forename: Y
authors.initials: Y
authors.lastname: Morita
authors.forename: M
authors.initials: M
authors.lastname: Motouri
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: T
authors.initials: T
authors.lastname: Suguri
authors.forename: S
authors.initials: S
authors.lastname: Aoe
authors.forename: H
authors.initials: H
authors.lastname: Kawakami
authors.forename: M
authors.initials: M
authors.lastname: Kumegawa
authors.forename: A
authors.initials: A
authors.lastname: Takeuchi
authors.forename: A
authors.initials: A
authors.lastname: Itabashi
mesh_terms: D000328:Adult; D015415:Biomarkers; D001846:Bone Development / Q000187:drug effects*; D001862:Bone Resorption / Q000517:prevention & control*; D002118:Calcium / Q000097:blood / Q000652:urine; D024042:Collagen Type I / Q000652:urine; D006801:Humans; D008297:Male; D008894:Milk Proteins / Q000494:pharmacology* / Q000627:therapeutic use*; D015675:Osteocalcin / Q000097:blood; D010446:Peptide Fragments / Q000097:blood; D011347:Procollagen / Q000097:blood
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D008894:Milk Proteins; D010446:Peptide Fragments; D011347:Procollagen; C042813:procollagen type I carboxy terminal peptide; D015675:Osteocalcin; D002118:Calcium