The new genetic era in reproductive medicine: possibilities, probabilities and problems.
The "New Genetic Era" will be a period of enormous exponential growth in our knowledge of the structure and function of the basic information blocks of life. The Human Genome Project will soon provide a complete and accurate sequence of the human genome. This will give us an abundance of basic genetic knowledge and provide a molecular understanding of disease, allowing for improved diagnosis and more sensitive and specific screening for disease. This will, we hope, lead to better treatments, prevention and cures through gene therapy, patient-specific drug design, and earlier and more specific behavioral interventions to prevent disease. With this information comes a complexity of legal, ethical and social concerns about potential use and abuse. The public has expressed its concerns about the potential for genetic discrimination. However, genetic information is enhancing our knowledge as to the causes of infertility, allowing diagnosis of more diseases in the prenatal period, and may aid our identification of patients at increased risk for breast and ovarian cancer. Doctors involved in reproductive medicine must become knowledgeable about the new genetic era so as to offer our patients the most appropriate and informed care.
Greene
R A
RA
Department of Obstetrics and Gynecology, Thomas Jefferson University Hospital,Philadelphia, Pennsylvania 19107, USA.
Jenkins
T M
TM
Wapner
R J
RJ
D019976:Cloning, Organism; D004992:Ethics, Medical; D005260:Female; D005544:Forecasting; D005820:Genetic Testing; D015316:Genetic Therapy; D006801:Humans; D007247:Infertility, Female / Q000235:genetics* / Q000628:therapy*; D008297:Male; D011247:Pregnancy