title: Disease recurrence after living liver transplantation for primary biliary cirrhosis: a clinical and histological follow-up study.
abstract: We describe the recurrence of primary biliary cirrhosis (PBC) in recipients of living liver transplants. We are not aware of similar previous reports. Because most donors for living liver transplantation (LLT) are blood relatives with close HLA matches, the recurrence of PBC in transplant recipients might offer additional insights in the pathogenesis of the condition. We studied 6 women (age, 29 to 61 years) with PBC who survived LLT for at least 1 year. Tests for antimitochondrial autoantibody (AMA), antipyruvate dehydrogenase complex-E2, immunoglobulin G (IgG) anti-M2, and IgM anti-M2 had confirmed the diagnosis. Donors were blood relatives in 5 instances, and one donor who was not a blood relative still had multiple HLA matches with the recipient. After LLT, we observed a decrease in AMA titers, but within 1 year, these titers increased again in 5 of the 6 patients to pre-LLT levels or greater. Immunoblotting analysis of the anti-M2 protein profile failed to show loss of bands and showed new bands in 3 of 6 patients. Histologically, strong evidence of recurrent PBC was found in 2 patients, and findings compatible with PBC were present in 1 additional patient. All 6 patients are doing well, without symptoms of recurrent PBC (median time post-LLT, 35.5 months; range, 12 to 50 months).
authors.affiliation: Institute of Gastroenterology, Tokyo Women's Medical University, Tokyo, Japan. etsuko@ige.twmu.ac.jp
authors.forename: E
authors.initials: E
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: S
authors.initials: S
authors.lastname: Noguchi
authors.forename: M
authors.initials: M
authors.lastname: Taniai
authors.forename: K
authors.initials: K
authors.lastname: Tokushige
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Takasaki
authors.forename: S
authors.initials: S
authors.lastname: Fuchinoue
authors.forename: J
authors.initials: J
authors.lastname: Ludwig
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D002761:Cholangitis / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006099:Granuloma / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis / Q000473:pathology / Q000601:surgery*; D016031:Liver Transplantation; D019520:Living Donors; D008875:Middle Aged; D008930:Mitochondria, Liver / Q000276:immunology; D012008:Recurrence
chemical_list: D001323:Autoantibodies