Length variation in HV2 of the human mitochondrial DNA control region.
Hair samples were typed from three individuals who exhibited length heteroplasmy in the homopolymeric cytosine stretches (C-stretch) in hypervariable region 2 (HV2). The study demonstrated that for different hairs within an individual, the HV2 C-stretch region can vary with respect to the number of cytosines and/or proportion of C-stretch length variants. Length heteroplasmy may occur regardless of the prominent length variant present in this region. Differences in the number of cytosines at the C-stretch region, or a variation in the relative amounts of heteroplasmic length variants, cannot be used to support an interpretation of exclusion.
Stewart
J E
JE
DNA Analysis Unit II, FBI Laboratory, Washington, DC 20535, USA.
Fisher
C L
CL
Aagaard
P J
PJ
Wilson
M R
MR
Isenberg
A R
AR
Polanskey
D
D
Pokorak
E
E
DiZinno
J A
JA
Budowle
B
B
D000595:Amino Acid Sequence; D003596:Cytosine; D004272:DNA, Mitochondrial / Q000235:genetics*; D005554:Forensic Medicine; D014644:Genetic Variation; D006197:Hair / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data
D004272:DNA, Mitochondrial; D003596:Cytosine