title: Human papillomavirus infection and survival in oral squamous cell cancer: a population-based study.
abstract: OBJECTIVE
  To determine whether human papillomavirus (HPV) type 16 affects survival in oral squamous cell carcinoma.
  
  
  METHODS
  Two hundred fifty-four patients diagnosed with primary oral cancer were studied for survival in relation to tumor HPV type 16 status. Kaplan-Meier analysis and Cox proportional hazard models were used to assess survival and estimate hazard ratios adjusted for potential confounders.
  
  
  RESULTS
  HPV type 16 DNA was detected in 15.1% of tumors. HPV 16 positive patients had significantly reduced all-cause mortality (hazard ratio [HR] estimates = 0.34, 95% CI = 0.14, 0.83) and disease-specific mortality (HR = 0.17, 95% CI = 0.04, 0.76) compared with HPV 16 negative patients after adjustment for age, stage, treatment, smoking, alcohol, education, and comorbid disease.
  
  
  CONCLUSIONS
  The presence of HPV type 16 DNA is independently associated with a favorable prognosis in patients with oral squamous cell carcinoma.
  
  
  CONCLUSIONS
  Although HPV genotyping is currently not widely available, it may provide important prognostic information.
authors.affiliation: Department of Otolaryngology - Head and Neck Surgery, School of Medicine, University of Washington, Seattle, USA. schwarsr@u.washington.edu
authors.forename: S R
authors.initials: SR
authors.lastname: Schwartz
authors.forename: B
authors.initials: B
authors.lastname: Yueh
authors.forename: J K
authors.initials: JK
authors.lastname: McDougall
authors.forename: J R
authors.initials: JR
authors.lastname: Daling
authors.forename: S M
authors.initials: SM
authors.lastname: Schwartz
mesh_terms: D017677:Age Distribution; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000453:epidemiology*; D015897:Comorbidity; D004279:DNA, Viral / Q000032:analysis; D015994:Incidence; D009062:Mouth Neoplasms / Q000175:diagnosis / Q000453:epidemiology*; D027383:Papillomaviridae / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis / Q000453:epidemiology*; D011159:Population Surveillance; D011336:Probability; D016016:Proportional Hazards Models; D012307:Risk Factors; D017678:Sex Distribution; D016019:Survival Analysis; D014412:Tumor Virus Infections / Q000175:diagnosis / Q000453:epidemiology*
chemical_list: D004279:DNA, Viral