Ulcerative colitis in a renal transplant patient with previous Goodpasture disease.
A renal transplant was performed in a 6-year-old boy who developed end stage renal disease (ESRD) after presenting with antiglomerular basement membrane (anti-GBM) disease. At 10 years of age he developed ulcerative colitis while being immunosuppressed with cyclosporin, prednisone, and azothioprine. He had a pancolectomy, and at 14 years has no symptoms of ulcerative colitis or anti-GBM disease. HLA typing revealed that he was homozygous for HLA DR2. The co-occurrence of anti-GBM disease and ulcerative colitis has not previously been described. Although there is no known common etiology for these two autoimmune diseases, we propose that the patient's homozygosity at HLA DR2 may have predisposed him to both.
Hibbs
A M
AM
Division of Nephrology, The Children's Hospital of Philadelphia, PA 19104, USA.
Bznik-Cizman
B
B
Guttenberg
M
M
Goldberg
B
B
Meyers
K
K
D019867:Anti-Glomerular Basement Membrane Disease / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002648:Child; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000209:etiology* / Q000503:physiopathology; D003106:Colon / Q000473:pathology; D003586:Cytomegalovirus Infections / Q000473:pathology; D015802:HLA-DR2 Antigen / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000601:surgery; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male
D015802:HLA-DR2 Antigen; D007166:Immunosuppressive Agents