title: Trends in human immunodeficiency virus type 1 (HIV-1) load among HIV-1-infected children with hemophilia.
abstract: In human immunodeficiency virus type 1 (HIV-1)-infected persons, virus load (serum/plasma level of HIV) predicts outcome. Virus load trends have been characterized in adults and infants but not in children. Virus load trends in 22 male children with hemophilia who acquired HIV-1 postnatally (age 0.7-5.2 years at seroconversion) were studied. The mean HIV-1 load 2 years after seroconversion was 4.40 log10 copies/mL, and the mean change over time (slope) was 0.03 log10 copies/(mL x year). Significant among-children variation was apparent: a random effects model predicted that 95% of children had early virus loads 3.75-5.04 log10 copies/mL and slopes -0.07 to 0.12 log10 copies/(mL x year). Higher early virus loads and higher slopes were each associated with increased mortality (P=.006 and P=.03, respectively). In conclusion, those subjects had virus load trends similar to those in adults. Early virus loads were lower than those in vertically infected infants, which suggests that factors changing soon after birth affect viral replication.
authors.affiliation: Viral Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland 20852, USA. engelse@exchange.nih.gov
authors.forename: E A
authors.initials: EA
authors.lastname: Engels
authors.forename: P S
authors.initials: PS
authors.lastname: Rosenberg
authors.forename: H
authors.initials: H
authors.lastname: Katki
authors.forename: J J
authors.initials: JJ
authors.lastname: Goedert
authors.forename: R J
authors.initials: RJ
authors.lastname: Biggar
mesh_terms: D000328:Adult; D002675:Child, Preschool; D018450:Disease Progression; D015658:HIV Infections / Q000097:blood / Q000503:physiopathology* / Q000821:virology; D006679:HIV Seropositivity / Q000503:physiopathology*; D015497:HIV-1 / Q000302:isolation & purification*; D006467:Hemophilia A / Q000097:blood / Q000821:virology*; D006801:Humans; D007223:Infant; D008297:Male; D008954:Models, Biological; D012044:Regression Analysis; D013997:Time Factors; D014481:United States; D019562:Viral Load / Q000639:trends*