New hemisynthetic manoyl oxide derivatives with antimicrobial activity.
The synthesis and antimicrobial activity of ten labdane-type diterpenes derived from ent-3-beta-hydroxy-13-epi-manoyl oxide (ribenol) is reported. The chloroethyl carbamidic ester 9 showed the strongest antimicrobial activity against all the tested gram (+), gram (-) bacteria and pathogenic fungi. Moreover, the glycoside 11 exhibited an interesting activity against the three tested fungi.
Kalpoutzakis
E
E
Laboratory of Pharmacognosy, University of Athens, Panepistimiopolis, Zografou, Greece.
Aligiannis
N
N
Mitaku
S
S
Chinou
L
L
Charvala
C
C
Skaltsounis
A L
AL
D000812:Anhydrides; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D007711:Klebsiella pneumoniae / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects; D013729:Terpenes / Q000138:chemical synthesis* / Q000494:pharmacology*
D000812:Anhydrides; D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D013729:Terpenes