Infections in multiple myeloma.
Multiple myeloma is a relatively rare but severe hematologic malignancy. Marked depression in production of normal immunoglobulins, mild neutropenia, and alkylant/steroid therapy or BMT/SCT all produce major suppression of the immune system in the totality of patients. Recurrent bacterial, fungal, and viral infections are an important cause of morbidity and the most common cause of death in these subjects. Prompt diagnosis and appropriate anti-infective chemotherapy are essential in order to reduce the risk of mortality.
Paradisi
F
F
Clinic of Infectious Diseases, University of Florence School of Medicine, Florence, Italy.
Corti
G
G
Cinelli
R
R
D001424:Bacterial Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D009101:Multiple Myeloma / Q000150:complications* / Q000473:pathology; D009181:Mycoses / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014777:Virus Diseases / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy