title: [Relative genetic effectiveness of fission neutrons in inducing various types of recessive mutation in Drosophila melanogaster].
abstract: The RCR-analysis of 53 gamma-Ray- and neutron-induced vg recessive mutations of Drosophila melanogaster combined with complementation assay with the vg[nw83b27] deletion mutation is used to detect precisely the RGE values of neutrons (0.85 MeV) under the chromosome and point (at the DNA level) mutation induction. Simultaneously, the induction-kinetics of gamma-ray- and neutron-induced macrodeletion as well as recessive lethal mutations in the X-chromosome were studied. The results obtained have shown that all genetic end-points increase linearly with gamma-ray or neutron dose. Thereby, the efficacy of neutrons is found to be twice (and more) as large as that of gamma-rays under the all macro- and micro-aberration mutation induction (macrodeletions and recessive lethals in the X-chromosome, multilocus deletions and intragenic deletions as well). Unlike that, the RGE of neutrons are more than twice as low as that of gamma-rays under the gene/point mutation induction. This feature of neutrons have been predicted as far back as in the early days of the radiation genetics (N.W. Timofeeff-Ressovsky, K.G. Zimmer, 1938), but experimentally supported at the DNA level just now.
authors.affiliation: Vavilov Institute of General Genetics, Russian Academy of Sciences, Moscow.
authors.forename: I D
authors.initials: ID
authors.lastname: Aleksandrov
authors.forename: M V
authors.initials: MV
authors.lastname: Aleksandrova
authors.forename: I L
authors.initials: IL
authors.lastname: Lapidus
authors.forename: S V
authors.initials: SV
authors.lastname: Korablinova
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004331:Drosophila melanogaster / Q000235:genetics / Q000528:radiation effects*; D005808:Genes, Recessive; D005816:Genetic Complementation Test; D009154:Mutation; D009502:Neutrons; D016133:Polymerase Chain Reaction; D014960:X Chromosome