Malignant fibrous histiocytoma of soft tissue producing granulocyte colony-stimulating factor.
We treated a rare case of malignant fibrous histiocytoma (MFH) of soft tissue that produced granulocyte colony-stimulating factor (G-CSF). The patient, an 80-year-old woman, was admitted because of a feeling of abdominal fullness and leg edema. An elastic, hard, tender tumor was palpated in the right thigh. Histopathological examinations of the tumor revealed atypical and prominent pleomorphic spindle-shaped cells with funicular arrangement, which were compatible with the diagnosis of MFH. Prominent leukocytosis (up to 84,300/microl), a high serum G-CSF concentration (82 pg/ml) and positive immunohistochemical staining of the tumor tissue for G-CSF indicated that G-CSF was produced by the MFH.
Mayumi
E
E
Department of Internal Medicine, Nipponkokan Fukuyama Hospital, Fukuyama, Hiroshima.
Okuno
T
T
Ogawa
T
T
Kurata
K
K
Ishioka
H
H
Hamamoto
H
H
Ishiki
K
K
Maga
T
T
Okamoto
T
T
Yoshida
T
T
Ogura
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism* / Q000556:secondary; D006801:Humans; D007866:Leg; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000378:metabolism* / Q000556:secondary
D016179:Granulocyte Colony-Stimulating Factor