Lipid peroxidation and the use of emulsified propofol in laparoscopic surgery.
BACKGROUND
Free radical-induced lipid peroxidation associated with a decrease of antioxidant capacity in plasma is observed after the deflation of the pneumoperitoneum in laparoscopic surgery. In this study, we evaluated the effect of the continuous administration of lipid peroxidation derivatives on emulsified propofol.


METHODS
Two groups of 20 patients each who underwent laparoscopic surgery were studied prospectively. Maintenance of anesthesia was achieved with 66% nitrous oxide and either isoflurane or continuous propofol administration. The level of thiobarbituric acid-reactive substances (TBARS) in the plasma was determined as a measure of free radicals before and after surgery.


RESULTS
Ten patients in the propofol group had reduced TBARS, as compared to only one in the isoflurane group (p = 0.003). There was a statistically significant difference in age between the patients with reduced TBARS and those without reduced TBARS (p = 0.009) in the propofol group.


CONCLUSIONS
Anesthesia with continuous propofol infusion in laparoscopic surgery has a significant scavenging action on the formation of free radicals and exerts its greatest antioxidant effect in patients >/=48 years of age.
Manataki
A D
AD
Department of Anesthesiology, "G. Hatzikosta" General Hospital, Makriyianni Avenue, 45001 Ioannina, Greece.
Tselepis
A D
AD
Glantzounis
G K
GK
Arnaoutoglou
H M
HM
Tsimoyiannis
E C
EC
Stavropoulos
N E
NE
D000769:Anesthesia, Inhalation / Q000379:methods*; D017081:Cholecystectomy, Laparoscopic; D005260:Female; D016166:Free Radical Scavengers / Q000378:metabolism; D005609:Free Radicals / Q000097:blood; D006801:Humans; D007530:Isoflurane / Q000008:administration & dosage / Q000378:metabolism; D010535:Laparoscopy / Q000379:methods*; D015227:Lipid Peroxidation / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000008:administration & dosage / Q000378:metabolism; D011028:Pneumoperitoneum, Artificial; D015742:Propofol / Q000008:administration & dosage* / Q000378:metabolism; D011446:Prospective Studies; D017392:Thiobarbituric Acid Reactive Substances / Q000032:analysis / Q000378:metabolism*; D014646:Varicocele / Q000601:surgery
D016166:Free Radical Scavengers; D005609:Free Radicals; D017392:Thiobarbituric Acid Reactive Substances; D007530:Isoflurane; D009609:Nitrous Oxide; D015742:Propofol