title: Necrotizing infundibular crystalline folliculitis.
abstract: We describe a 22-year-old woman with a background of acne who developed multiple folliculocentric facial papules associated with sharply demarcated waxy, keratotic plugs. Multiple skin biopsies showed umbilicated craters that were filled with dispersed bundles of eosinophilic filaments embedded in a pale amorphous matrix forming a plug. The plugs bulged into the upper dermis. Serial sections showed vacuolar and filamentous destruction of the infundibular and adjacent perifollicular epithelium and a close relationship of the crystalline necrosis to follicles. Electron microscopy revealed that the filamentous bundles were tonofilaments. No fresh material was available for polarization and the paraffin sections failed to polarize. The clinical and pathological findings of the lesions in our patient were identical to those reported as a new perforating disorder with urate-like crystals. Our case indicates that the process may represent crystalline folliculocentric necrosis rather than a primary perforating disorder. The nature and basis of the crystals that have a urate-like appearance remain to be determined.
authors.affiliation: Skin and Cancer Foundation Australia, 277 Bourke Street, Darlinghurst, NSW 2010, Australia. kossards@zip.com.au
authors.forename: S
authors.initials: S
authors.lastname: Kossard
authors.forename: J
authors.initials: J
authors.lastname: Scurry
authors.forename: M
authors.initials: M
authors.lastname: Killingsworth
mesh_terms: D000328:Adult; D003460:Crystallization; D005148:Facial Dermatoses / Q000378:metabolism / Q000473:pathology*; D005260:Female; D005499:Folliculitis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D009336:Necrosis; D014527:Uric Acid / Q000032:analysis
chemical_list: D014527:Uric Acid