title: Autoimmune neutropenia in pregnant women causing neonatal neutropenia.
abstract: Autoimmune neutropenia (AIN) can occur during pregnancy. However, neonatal neutropenia occurring in an infant born to a mother with AIN has only rarely been documented. Recently, we have experienced two cases of AIN during pregnancy, both of which caused severe yet transient neonatal neutropenia (< 0.3 x 10(9)/l), probably as a result of transplacental maternal anti-neutrophil autoantibodies. The anti-neutrophil antibodies seemed to be against antigens other than NA1/NA2 because the autoantibodies did not bind to neutrophils of specific NA types selectively in the granulocyte indirect immunofluorescence test. Although AIN is a relatively uncommon disease, neonatal neutropenia caused by maternal AIN may not be quite as rare.
authors.affiliation: Department of Rheumatology and Haematology, Tohoku University School of Medicine, Sendai, Japan. jkame@gonryo.med.tohuko.ac.jp
authors.forename: J
authors.initials: J
authors.lastname: Kameoka
authors.forename: T
authors.initials: T
authors.lastname: Funato
authors.forename: T
authors.initials: T
authors.lastname: Miura
authors.forename: H
authors.initials: H
authors.lastname: Harigae
authors.forename: J
authors.initials: J
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Yokoyama
authors.forename: S
authors.initials: S
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Yamada
authors.forename: O
authors.initials: O
authors.lastname: Sasaki
authors.forename: M
authors.initials: M
authors.lastname: Imaizumi
authors.forename: N
authors.initials: N
authors.lastname: Takata
authors.forename: K
authors.initials: K
authors.lastname: Meguro
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D009503:Neutropenia / Q000276:immunology*; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000276:immunology*; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic