On-line monitoring of substrate delivery and brain metabolism in head injury.
Head injury is associated with complex pathophysiological changes in metabolism. The objective of the study was to investigate these changes by applying on-line bedside monitoring of cerebral metabolism using microdialysis. Following approval by the Local Ethics Committee and consent from the next of kin, a microdialysis catheter was inserted into the frontal cortex of patients with severe head injury. Twenty-one patients were studied for 102.3 +/- 26.9 hours (mean +/- 95% confidence interval; total 89.4 patient monitoring days). The overall cerebral glucose (mean of means) was 1.63 +/- 0.31 mM with periods of undetectable glucose recorded. The cerebral lactate and lactate/pyruvate ratio were 4.69 +/- 0.61 mM and 29.9 +/- 3.73 respectively. Patients who died (n = 4) or who were severely disabled (not proceeding to rehabilitation, n = 5) had a tendency towards lower glucose (1.39 +/- 0.35 mM), higher lactate (5.10 +/- 1.02 mM) and higher lactate/pyruvate ratios (35.5 +/- 7.67) compared to patients with good outcome (home or proceeding to rehabilitation, n = 12, glucose 1.80 +/- 0.49 mM, lactate 4.38 +/- 0.85 mM, lactate/pyruvate ratio 27.9 +/- 4.33). Trends in these metabolic parameters relating to outcome were identifiable. In the majority of patients, cerebral glutamate levels (overall mean of means 9.47 +/- 4.59 microM) were initially high and then declined to stable levels. Patients in whom the glutamate level remained elevated or in whom secondary rises in glutamate were seen had a poor outcome. The application of bedside analysis of microdialysis enables the progress of the patient to be monitored on-line. In addition to establishing trends of improving and deteriorating metabolism, the technique has the potential to monitor the effects of therapeutic manoeuvres on the biochemistry.
Hutchinson
P J
PJ
Academic Department of Neurosurgery, Department of Neuroanaesthesia and Medical Research Council, Centre for Brain Repair, University of Cambridge, UK.
al-Rawi
P G
PG
O'Connell
M T
MT
Gupta
A K
AK
Maskell
L B
LB
Hutchinson
D B
DB
Pickard
J D
JD
Kirkpatrick
P J
PJ
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D001930:Brain Injuries / Q000175:diagnosis* / Q000401:mortality / Q000503:physiopathology; D002408:Catheters, Indwelling; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000293:injuries / Q000503:physiopathology; D018698:Glutamic Acid / Q000378:metabolism; D006801:Humans; D019344:Lactic Acid / Q000378:metabolism; D008297:Male; D017551:Microdialysis / Q000295:instrumentation*; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D009862:Online Systems; D011379:Prognosis; D019289:Pyruvic Acid / Q000378:metabolism; D015996:Survival Rate
D001786:Blood Glucose; D019344:Lactic Acid; D018698:Glutamic Acid; D019289:Pyruvic Acid