title: Comparison of effects of ioxaglate versus iomeprol on histamine and tryptase release in patients with ischemic cardiomyopathy.
abstract: We observed a release of histamine, but not of tryptase, in arterial blood from 64 patients with ischemic heart disease and 24 patients without coronary disease, which was provoked by ioxaglate, a ionic compound, but was not provoked by iomeprol, a non-ionic radiocontrast compound. The release of histamine in arterial blood after ionic contrast medium injection was higher in patients with ischemic heart disease compared with patients without coronary disease, suggesting that an increased release from heart mast cells previously observed exists also for systemic blood basophils.
authors.affiliation: Service de Cardiologie, CHU de Nancy-Brabois, Vandoeuvre, France. rossyrod@club-internet.fr
authors.forename: R M
authors.initials: RM
authors.lastname: Rodriguez
authors.forename: J L
authors.initials: JL
authors.lastname: Guéant
authors.forename: I A
authors.initials: IA
authors.lastname: Gastin
authors.forename: M
authors.initials: M
authors.lastname: Angioi
authors.forename: I
authors.initials: I
authors.lastname: Abdelmoutaleb
authors.forename: J
authors.initials: J
authors.lastname: Saint-Laudy
authors.forename: P
authors.initials: P
authors.lastname: Gérard
authors.forename: F
authors.initials: F
authors.lastname: Namour
authors.forename: A
authors.initials: A
authors.lastname: Grentzinger
authors.forename: A
authors.initials: A
authors.lastname: Romano
authors.forename: Y
authors.initials: Y
authors.lastname: Juillière
authors.forename: N
authors.initials: N
authors.lastname: Danchin
mesh_terms: D001491:Basophils / Q000276:immunology; D016022:Case-Control Studies; D003287:Contrast Media / Q000494:pharmacology*; D017023:Coronary Angiography; D005260:Female; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D007479:Iopamidol / Q000031:analogs & derivatives* / Q000276:immunology; D007485:Ioxaglic Acid / Q000276:immunology; D008297:Male; D008407:Mast Cells / Q000276:immunology; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000276:immunology*; D011446:Prospective Studies; D012697:Serine Endopeptidases / Q000378:metabolism*; D053802:Tryptases
chemical_list: D003287:Contrast Media; D018836:Inflammation Mediators; C057937:iomeprol; D012697:Serine Endopeptidases; D053802:Tryptases; D007479:Iopamidol; D007485:Ioxaglic Acid