[Rugulosuvines A and B--diketopiperazine alkaloids from Penicillium rugulosum and Penicillium piscarium fungi].
Two diketopiperazine alkaloids, rugulosuvines A and B (tryptophan and phenylalanine are precursors), were isolated and purified from the culture liquid of Penicillium rugulosum VKM F-352 and Penicillium piscarium VKM F-325 fungi. Physical and physicochemical studies showed the absolute structure of rugulosuvine A. The absolute structure of rugulosuvine B was demonstrated to be similar to that of rugulosuvine A.
Kozlovskiĭ
A G
AG
G. K. Skryabin Institute of Biochemistry and Physiology of Microorganisms, Russian Academy of Sciences, prosp. Nauki 5, Pushchino, 142290 Russia.
Adanin
V M
VM
Dahse
H M
HM
Grafe
U
U
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D010407:Penicillium / Q000737:chemistry*; D010649:Phenylalanine; D010879:Piperazines / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014364:Tryptophan; D014407:Tumor Cells, Cultured
D000470:Alkaloids; D000970:Antineoplastic Agents; D010879:Piperazines; C446860:rugulosuvine A; C446861:rugulosuvine B; D010649:Phenylalanine; D014364:Tryptophan