title: Mollusk-derived growth factor: cloning and developmental expression in the central nervous system and reproductive tract of Aplysia.
abstract: We have isolated and characterized an atrial gland cDNA that corrects the previously reported sequence for Aplysia atrial gland granule-specific antigen (AGSA), a glycoprotein of unknown function. We designated the protein mollusk-derived growth factor (MDGF) to distinguish the revised sequence from AGSA and to emphasize its similarity to an insect-derived growth factor (IDGF). We describe MDGF mRNA expression that suggests a possible role during embryonic development and CNS injury repair.
authors.affiliation: Marine Biomedical Institute and Department of Anatomy and Neurosciences, University of Texas Medical Branch, Medical Research Building, Galveston, TX 77555-1043, USA. dakalal@utmb.edu
authors.forename: D B
authors.initials: DB
authors.lastname: Akalal
authors.forename: G T
authors.initials: GT
authors.lastname: Nagle
mesh_terms: D000243:Adenosine Deaminase / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D001048:Aplysia / Q000235:genetics*; D001483:Base Sequence; D002490:Central Nervous System / Q000502:physiology; D003001:Cloning, Molecular; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006066:Gonads / Q000502:physiology; D006133:Growth Substances / Q000235:genetics / Q000378:metabolism*; D007288:Inosine / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis
chemical_list: D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D012333:RNA, Messenger; D007288:Inosine; D000243:Adenosine Deaminase; C435026:mollusk-derived growth factor