Met-enkephalin levels during PTCA-induced myocardial ischemia.
Met-enkephalin (Met-enk) has been demonstrated to modulate myocardial-ischemia mechanisms via the opioid receptors, but no studies are now available on Met-enk levels in the coronary circulation. In this experience Met-enk levels were evaluated in aortic root and in coronary sinus at baseline (T0), during PTCA induced transient ischemia (T1) and during reperfusion (T2). No significant differences were found at any time. Thus, it appears that there is no Met-enk extraction from the coronary circulation during provoked myocardial ischemia and no Met-enk release from the ischemic heart.
Parlapiano
C
C
Dipartimento di Scienze Cliniche, Endocrinologia, Policlinico Umberto I Università degli Studi di Roma La Sapienza, Viale del Policlinico 155, 00161 Rome, Italy. Papitebe@hotmail.com
Borgia
M C
MC
Tonnarini
G
G
Giancaspro
G
G
Pizzuto
F
F
Campana
E
E
Giovanniello
T
T
Pantone
P
P
Vincentelli
G M
GM
Alegiani
F
F
Negri
M
M
D000368:Aged; D015906:Angioplasty, Balloon, Coronary / Q000009:adverse effects*; D001011:Aorta / Q000378:metabolism*; D004744:Enkephalin, Methionine / Q000096:biosynthesis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000139:chemically induced*; D009206:Myocardium / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism; D015427:Reperfusion Injury
D012333:RNA, Messenger; D004744:Enkephalin, Methionine