Exacerbation of Wegener's Granulomatosis following Single Administration of Monoclonal Antibody 17-1A (Panorex((R))) during Adjuvant Immunotherapy of Colon Cancer.
BACKGROUND: Immunotherapy with monoclonal antibody 17-1A (mAb 17-1A) has been shown effective as an adjuvant treatment in UICC stage III colon carcinoma. Usually, severe side effects are infrequent with mAb 17-1A treatment. CASE REPORT: A 64-year-old man had a 18-month history of recurring arthralgia, sinusitis, and conjunctivits. After curative resection of UICC stage II colon cancer adjuvant treatment with mAb 17-1A was initiated. After the first administration (500 mg) the patient experienced an aggravation of the above-mentioned symptoms which led to the diagnosis of Wegener's granulomatosis with multiorgan involvement. Under immunosuppressive therapy with cyclophosphamide and prednisone, clinical stabilization could be achieved. CONCLUSION: The exacerbation of Wegener's granulomatosis occurred immediately after the first administration of mAb 17-1A. This suggests that mAb 17-1A should be applied cautiously in autoimmune disease. Copyright 2000 S. Karger GmbH, Freiburg
Franz
A.
A
Onkologisches Zentrum, III. Medizinische Klinik, Universitätsklinikum Mannheim.
Bewersdorf
H.
H
Hartung
G.
G
Dencausse
Y.
Y
Queisser
W.
W