Role for p53 in gene induction by double-stranded RNA.
Cross talk between p53 and interferon-regulated pathways is implicated in the induction of gene expression by biologic and genotoxic stresses. We demonstrate that the interferon-stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction by double-stranded RNA (dsRNA), but not interferon. Interestingly, virus induces ISG15 in the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.
Hummer
B T
BT
Greenebaum Cancer Center, The University of Maryland, Baltimore, Maryland 21201, USA.
Li
X L
XL
Hassel
B A
BA
D000818:Animals; D002460:Cell Line; D015967:Gene Expression Regulation, Viral; D016158:Genes, p53; D007372:Interferons / Q000235:genetics*; D051379:Mice; D012313:RNA / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D015533:Transcriptional Activation
D012367:RNA, Viral; D012313:RNA; D007372:Interferons