title: New technologies in spine: kyphoplasty and vertebroplasty for the treatment of painful osteoporotic compression fractures.
abstract: METHODS
  Literature review.
  
  
  OBJECTIVE
  To describe new treatments for painful osteoporotic compression fractures in light of available scientific literature and clinical experience.
  
  
  BACKGROUND
  Painful vertebral osteoporotic compression fractures lead to significant morbidity and mortality. This relates to pulmonary dysfunction, eating disorders (nutritional deficits), pain, loss of independence, and mental status change (related to pain and medications). Medications to treat osteoporosis (primarily antiresorptive) do not effectively treat the pain or the fracture, and require over 1 year to reduce the degree of osteoporosis. Kyphoplasty and vertebroplasty are new techniques that help decrease the pain and improve function in fractured vertebrae.
  
  
  METHODS
  This is a descriptive review of the background leading to vertebroplasty and kyphoplasty, a description of the techniques, a review of the literature, as well as current ongoing studies evaluating kyphoplasty.
  
  
  RESULTS
  Both techniques have had a very high acceptance and use rate. There is 95% improvement in pain and significant improvement in function following treatment by either of these percutaneous techniques. Kyphoplasty improves height of the fractured vertebra, and improves kyphosis by over 50%, if performed within 3 months from the onset of the fracture (onset of pain). There is some height improvement, though not as marked, along with 95% clinical improvement, if the procedure is performed after 3 months. Complications occur with both and relate to cement leakage in both, and cement emboli with vertebroplasty.
  
  
  CONCLUSIONS
  Kyphoplasty and vertebroplasty are safe and effective, and have a useful role in the treatment of painful osteoporotic vertebral compression fractures that do not respond to conventional treatments. Kyphoplasty offers the additional advantage of realigning the spinal column and regaining height of the fractured vertebra, which may help decrease the pulmonary, GI, and early morbidity consequences related to these fractures. Both procedures are technically demanding.
authors.affiliation: University of California, San Diego, California, USA. SGARFIN@UCSD.EDU
authors.forename: S R
authors.initials: SR
authors.lastname: Garfin
authors.forename: H A
authors.initials: HA
authors.lastname: Yuan
authors.forename: M A
authors.initials: MA
authors.lastname: Reiley
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001843:Bone Cements / Q000627:therapeutic use*; D005260:Female; D005593:Fracture Fixation, Internal / Q000379:methods*; D005598:Fractures, Spontaneous / Q000601:surgery; D006801:Humans; D007278:Injections, Spinal; D007738:Kyphosis / Q000150:complications / Q000601:surgery*; D010024:Osteoporosis / Q000150:complications / Q000601:surgery*; D010146:Pain / Q000601:surgery; D019904:Polymethyl Methacrylate / Q000008:administration & dosage; D016103:Spinal Fractures / Q000209:etiology / Q000601:surgery*; D013131:Spine / Q000601:surgery*; D016896:Treatment Outcome
chemical_list: D001843:Bone Cements; D019904:Polymethyl Methacrylate