Combination treatment in autoimmune diseases. Methodology of combination trials.
Even with the limited number of antirheumatic agents available, theoretical considerations lead to an almost infinite number of combination strategies. This article outlines possible strategies based on the primary choice between maximization of efficacy or minimization of toxicity. Strategies are illustrated with examples from trial experience in the field of rheumatoid arthritis.
Boers
M
M
Department of Clinical Epidemiology & Biostatistics, University Hospital Vrije Universiteit, Amsterdam, The Netherlands.
D018501:Antirheumatic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic / Q000379:methods*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D016896:Treatment Outcome
D018501:Antirheumatic Agents