title: Estimation of the VA/(Q+VTIS) distribution from single-breath alkane uptake.
abstract: In this paper, it was investigated if the ventilation-perfusion distribution can be estimated from the uptake (U) of inert gases with different solubilities during the single-breath maneuver. A model was implemented that describes U as a function of solubility for inhomogeneously distributed alveolar volume (VA) versus blood and tissue volume (Q + VTIS). The VA/(Q + VTIS) distribution describes the relative contribution of gas-exchange units with different VA/(Q + VTIS) ratios to the expiratory volume. U was derived as the sum of uptakes corresponding to different modes in the distribution, weighted with the relative contribution to the expiratory volume. This permits an estimation of the distribution parameters by fitting U as a function of solubility. The n alkanes were used because of their different solubilities. Analysis of the sensitivity of the estimated VA/(Q + VTIS) distribution parameters to measurement errors showed that mostly two modes can be discerned. The influence of fixed model parameters appeared relatively small. The model could well explain U in normal and emphysematous subjects, with a larger contribution of high VA/(Q + VTIS) ratios in the emphysematous subjects. It was concluded that the VA/(Q + VTIS) distribution can be estimated noninvasively from single-breath alkane uptake.
authors.affiliation: Department of Pulmonology, Leiden University Medical Center, University of Amsterdam, The Netherlands. jvdaardweg@lumc.nl
authors.forename: J G
authors.initials: JG
authors.lastname: van den Aardweg
authors.forename: S
authors.initials: S
authors.lastname: Kezic
authors.forename: J A
authors.initials: JA
authors.lastname: Bosch
authors.forename: A C
authors.initials: AC
authors.lastname: Monster
mesh_terms: D000042:Absorption; D000328:Adult; D000368:Aged; D000473:Alkanes / Q000493:pharmacokinetics*; D001944:Breath Tests; D001991:Bronchitis / Q000503:physiopathology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology; D008297:Male; D008954:Models, Biological; D008970:Molecular Weight; D011659:Pulmonary Gas Exchange; D012016:Reference Values; D014692:Ventilation-Perfusion Ratio
chemical_list: D000473:Alkanes