Screening of drug candidates for their drug--drug interaction potential.
Within the past year, additional papers have been published that focus on higher-throughput drug-interaction screening. Some papers have described enzyme assays that can be used to evaluate inhibition or induction of the human cytochrome P450s. At the same time, numerous investigators have developed computational (in silico) methods to predict interactions and have validated the approach using in vitro (assay-derived) data. These so called 'in silico--in vitro' correlations have great potential and may complement existing 'in vitro--in vivo' correlations.
Rodrigues
A D
AD
Drug Metabolism, Merck Research Laboratories, Sumneytown Pike, West Point, Pennsylvania 19486, USA. david_rodrigues@merck.com
Lin
J H
JH
D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004790:Enzyme Induction
D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System