title: Human enteric viruses in Coquina clams associated with a large hepatitis A outbreak.
abstract: An outbreak of hepatitis A, affecting 183 people, occurred in Valencia (Spain). Epidemiological evidence pointed to an association of the outbreak with consumption of Coquina clams (Donax sp), imported frozen from Peru. Shellfish were analysed for the presence of hepatitis A virus (HAV), enteroviruses, rotaviruses, astroviruses, caliciviruses and hepatitis E virus. HAV was detected in 75% of assayed shellfish samples. Other enteric viruses were occasionally found in the same samples. Molecular epidemiological analysis of fragments of the VP1/2A and the 5' end of the genome from shellfish and sera isolates, revealed the presence of six variants belonging to a single genotype.
authors.affiliation: Department of Microbiology, University of Barcelona, 08028 Barcelona, Spain. albert@porthos.bio.ub.es
authors.forename: A
authors.initials: A
authors.lastname: Bosch
authors.forename: G
authors.initials: G
authors.lastname: Sánchez
authors.forename: F
authors.initials: F
authors.lastname: Le Guyader
authors.forename: H
authors.initials: H
authors.lastname: Vanaclocha
authors.forename: L
authors.initials: L
authors.lastname: Haugarreau
authors.forename: R M
authors.initials: RM
authors.lastname: Pintó
mesh_terms: D004279:DNA, Viral / Q000032:analysis*; D004196:Disease Outbreaks; D016021:Epidemiologic Studies; D005506:Food Contamination; D006506:Hepatitis A / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012758:Shellfish / Q000821:virology*; D013030:Spain / Q000453:epidemiology
chemical_list: D004279:DNA, Viral