title: Simultaneous determination of codeine and ethyl morphine HCL in tablet formulations using LC.
abstract: A reverse phase high performance liquid chromatography (HPLC) method was developed for the simultaneous determination of codeine (methyl morphine) and dionin (ethyl morphine hydrochloride) in antitussive analgesic tablet formulations. A C(18) column and methanol-water (1:2) mixture mobile phase (pH 3.0) were used. Spectrophotometric detection was carried out at 210 nm. The total elution time was shorter than 7 min. This method was found to be quite precise and reproducible. This proposed method was successfully applied to the determination of codeine and ethyl morphine hydrochloride in tablets produced by the Turkish Army Drug Factory.
authors.affiliation: Department of Quality Control, Army Drug Factory, Dişkapi, Ankara, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Değim
authors.forename: C
authors.initials: C
authors.lastname: Akay
authors.forename: K
authors.initials: K
authors.lastname: Büyükafşar
authors.forename: S
authors.initials: S
authors.lastname: Cevheroğlu
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D003061:Codeine / Q000032:analysis*; D004355:Drug Stability; D009022:Morphine Derivatives / Q000032:analysis*; D013607:Tablets; D013696:Temperature
chemical_list: D009022:Morphine Derivatives; D013607:Tablets; D003061:Codeine