title: HLA system. Phenotypic and gene frequencies in celiac and healthy subjects from the same geographical area.
abstract: OBJECTIVE
  To compare the phenotypic and gene frequencies of the HLA system in celiac and healthy subjects the same geographical area.
  
  
  METHODS
  HLA A, B, C, DR and DQ phenotypic and gene frequencies have been estimated in 38 celiac children and healthy subjects. The HLA typing has been done according to the microlymphocytotoxicity assay. The individual HLA antigen frequencies in each group have been compared by Chi-square test using Yates correction. For each specificity, the strength of association with celiac disease has been estimated by Odds Ratio and 95% confidence limit.
  
  
  RESULTS
  The comparative study of both population show increased phenotypic and gene frequencies among celiac patients and significant differences compared with healthy subjects for B8, Cw7, DR3, DR7 and DQ2. On the contrary, Cw4 and DQ1 phenotypic and gene frequencies are significantly increased in the control population.
  
  
  CONCLUSIONS
  Our findings support the role of HLA antigens as predisposing factors for celiac disease. The presence of Cw4 and DQ1 can be a protective factor against such disease.
authors.affiliation: Department of Pediatrics, University Hospital Lozano Blesa, University of Zaragoza Medical School, Zaragoza, Spain.
authors.forename: M Y
authors.initials: MY
authors.lastname: Ruiz del Prado
authors.forename: J L
authors.initials: JL
authors.lastname: Olivares López
authors.forename: A
authors.initials: A
authors.lastname: Lázaro Almarza
authors.forename: M P
authors.initials: MP
authors.lastname: Lasierra Díaz
mesh_terms: D000293:Adolescent; D002446:Celiac Disease / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D010641:Phenotype; D013030:Spain
chemical_list: D006680:HLA Antigens