title: The chemical and biological properties of methoxyfenozide, a new insecticidal ecdysteroid agonist.
abstract: Methoxyfenozide [N-tert-butyl-N'-(3-methoxy-o-toluoyl)-3,5-xylohydrazide; RH-2485] is the newest diacylhydrazine insecticide to reach the marketplace. It binds with very high affinity to the ecdysone receptor complex (EcR:USP) in lepidopteran insects [Kd = 0.5 nM (Plodia)], where it functions as a potent agonist, or mimic, of the insect molting hormone, 20-hydroxyecdysone (20E). Methoxyfenozide exhibits high insecticidal efficacy against a wide range of important caterpillar pests, including many members of the family Pyralidae, Pieridae, Tortricidae and Noctuidae. It is most effective when ingested by the target caterpillar, but it also has some topical and ovicidal properties. It is modestly root systemic, but not significantly leaf-systemic. Evidence collected to date indicates that methoxyfenozide has an excellent margin of safety to non-target organisms, including a wide range of non-target and beneficial insects.
authors.affiliation: Rohm and Haas Research Laboratories, 727 Norristown Road, Spring House, PA 19477, USA. rsagrc@rohmhaas.com
authors.forename: G R
authors.initials: GR
authors.lastname: Carlson
authors.forename: T S
authors.initials: TS
authors.lastname: Dhadialla
authors.forename: R
authors.initials: R
authors.lastname: Hunter
authors.forename: R K
authors.initials: RK
authors.lastname: Jansson
authors.forename: C S
authors.initials: CS
authors.lastname: Jany
authors.forename: Z
authors.initials: Z
authors.lastname: Lidert
authors.forename: R A
authors.initials: RA
authors.lastname: Slawecki
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D004441:Ecdysterone / Q000819:agonists / Q000378:metabolism; D006834:Hydrazines / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D007306:Insecticides / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D007605:Juvenile Hormones / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D007915:Lepidoptera; D007928:Lethal Dose 50; D018716:Molecular Mimicry; D015394:Molecular Structure; D011987:Receptors, Steroid / Q000378:metabolism
chemical_list: D006834:Hydrazines; D007306:Insecticides; D007605:Juvenile Hormones; D011987:Receptors, Steroid; C055469:ecdysone receptor; D004441:Ecdysterone; C406712:methoxyfenozide