Large-scale production of mouse phenotypes: the search for animal models for inherited diseases in humans.
This paper is aimed principally at bioinformaticians and biologists as an introduction to recent advances in mouse mutagenesis, concentrating on genome-wide screens utilising the powerful mutagen N-ethyl-N-nitroso-urea (ENU). It contains a brief background to the underlying genetics as well as details of the practical aspects of organisation and data capture for such projects.
Hrabé de Angelis
M
M
Institute of Experimental Genetics at the GSF Research Centre for Environment and Health, Munich, Germany.
Strivens
M
M
D000818:Animals; D019295:Computational Biology; D003627:Data Interpretation, Statistical; D016208:Databases, Factual; D004195:Disease Models, Animal; D005038:Ethylnitrosourea / Q000633:toxicity; D005260:Female; D030342:Genetic Diseases, Inborn / Q000235:genetics; D006801:Humans; D008297:Male; D051379:Mice / Q000235:genetics*; D016296:Mutagenesis; D009153:Mutagens / Q000633:toxicity; D010641:Phenotype; D012662:Semen Preservation
D009153:Mutagens; D005038:Ethylnitrosourea