title: [Integra, a new surgical alternative for the treatment of massive burns. Clinical evaluation of acute and reconstructive surgery: 39 cases].
abstract: Early excision and prompt coverage in severely burned patients are the best way to lessen morbidity and improve survival. Repair of full-thickness burns requires replacement of both dermal and epidermal components of skin and treatment with split thickness autografts replaces both of them. But healthy skin is not sufficient in extensive burns. Alternative to split thickness skin grafts have been studied by several groups including epidermis, dermis or a complete replacement comprising epidermis and dermis. Because of the difficulties in homografts supplying, a new way was use to replace the dermis. In 1981, Yannas and Burke were the first to develop such a matrix. Intégra is available in France since 1997 and was used in our service for the treatment of both acute and reconstructive surgery for burned patients. Twenty patients were treated for acute surgery. Nineteen patients were treated for reconstructive surgery of burn scar contractures. Fifty-one grafts of Intégra were performed. Long-term final results seem to show that Intégra improve cosmetical and functional results and is a new surgical alternative for the treatment of burns in the acute phase as well as in late surgery of deformities.
authors.affiliation: Service des brûlés, hôpital Léon Bérard, 83400 Hyères, France.
authors.forename: E
authors.initials: E
authors.lastname: Dantzer
authors.forename: P
authors.initials: P
authors.lastname: Queruel
authors.forename: L
authors.initials: L
authors.lastname: Salinier
authors.forename: B
authors.initials: B
authors.lastname: Palmier
authors.forename: J F
authors.initials: JF
authors.lastname: Quinot
mesh_terms: D000203:Activities of Daily Living; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001672:Biocompatible Materials / Q000600:supply & distribution / Q000627:therapeutic use*; D001706:Biopsy; D002056:Burns / Q000145:classification / Q000150:complications* / Q000473:pathology; D002648:Child; D002809:Chondroitin Sulfates; D003094:Collagen; D003286:Contracture / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005602:France; D006801:Humans; D015601:Injury Severity Score; D008297:Male; D008875:Middle Aged; D016062:Porosity; D019651:Plastic Surgery Procedures; D016038:Skin Transplantation; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous; D016896:Treatment Outcome; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; C114835:integra artificial skin; D002809:Chondroitin Sulfates; D003094:Collagen