title: Effects of steroid hormones on age-related expression and modulation of the lysozyme gene of the oviduct of Japanese quail.
abstract: The expression of lysozyme gene in the oviduct of Japanese quail is age-dependent. Here we show that the expression of the gene is altered by three steroid hormones: 17beta-estradiol (E), progesterone (P) and glucocorticoid (dexamethasone, G), and their combinations E+P, E+G and P+G. We also show that the levels/affinities of transacting factors that bind to specific cis-acting elements in the promoter region of the gene change with age and after steroid administration. These factors are sequence-specific, age and steroid-dependent. It is proposed that administration of appropriate doses of steroid hormones after adulthood may extend the reproductive function and egg laying period in birds.
authors.affiliation: Department of Zoology, Banaras Hindu University, Varranasi, India.
authors.forename: A
authors.initials: A
authors.lastname: Hegde
authors.lastname: Kanungo
mesh_terms: D000367:Age Factors; D000818:Animals; D015152:Blotting, Northern; D002467:Cell Nucleus / Q000378:metabolism; D003370:Coturnix / Q000235:genetics*; D004247:DNA / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004587:Electrophoresis, Agar Gel; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation; D005938:Glucocorticoids / Q000494:pharmacology; D008957:Models, Genetic; D009113:Muramidase / Q000235:genetics*; D010057:Oviducts / Q000201:enzymology / Q000378:metabolism; D010957:Plasmids / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology; D011401:Promoter Regions, Genetic; D012313:RNA / Q000378:metabolism; D015183:Restriction Mapping; D013256:Steroids / Q000494:pharmacology*; D015533:Transcriptional Activation
chemical_list: D005938:Glucocorticoids; D013256:Steroids; D011374:Progesterone; D004958:Estradiol; D012313:RNA; D003907:Dexamethasone; D004247:DNA; D009113:Muramidase