Dexamethasone increases inhibin and estradiol secretion mediated by endogenous FSH in equine chorionic gonadotropin (eCG)-primed immature female rats.
In the present study, we have examined whether the effects of dexamethasone on follicle stimulating hormone (FSH) secretion were mediated by hypophysiotropic factors, and whether the increased levels of FSH induced by dexamethasone can stimulate ovarian functions in equine chorionic gonadotropin (eCG)-primed immature female rats. Dexamethasone (500 microg) significantly increased serum concentrations of FSH in hypophysectomized rats implanted with pituitary under the kidney capsule, as well as in intact rats. Serum concentrations of inhibin and estradiol in eCG (2.5, 5 i.u.)-primed rats were significantly increased by simultaneous treatment with dexamethasone (500 microg) and eCG. These simultaneous effects were not confirmed in hypophysectomized rats. The results had shown that hypophysiotropic factors do not mediate the selective increase of FSH secretion caused by dexamethasone. Dexamethasone induces the excess amount of FSH secretion from anterior pituitary and this FSH can stimulate inhibin and estradiol secretion in eCG-primed immature female rat.
Tohei
A
A
Department of Pharmacology, Tokyo University of Pharmacy and Life Science, Hachioji, Japan.
Sakamoto
H
H
Kogo
H
H
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D005938:Glucocorticoids / Q000494:pharmacology*; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D007016:Hypophysectomy; D007265:Inhibins / Q000378:metabolism*; D007668:Kidney / Q000601:surgery; D006080:Ovarian Follicle / Q000187:drug effects* / Q000378:metabolism; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism* / Q000601:surgery; D051381:Rats; D017208:Rats, Wistar
D004338:Drug Combinations; D005938:Glucocorticoids; D006064:Gonadotropins, Equine; D004958:Estradiol; D007265:Inhibins; D003907:Dexamethasone; D005640:Follicle Stimulating Hormone