[I/D polymorphism in the angiotensin-converting enzyme gene in men with myocardial infarction at young age].
The rate of D allele did not differ between patients with ischemic heart disease (IHD) who had myocardial infarction before the age 45, and healthy males. The DD genotype of the ACE gene was much more frequently encountered in the patients than in healthy males. The findings suggest that the DD genotype is an independent risk factor of the IHD and myocardial infarction in young patients.
Berkovich
O A
OA
St. Petersburg I. P. Pavlov State Medical University, 197022, St. Petersburg, Leo Tolstoy St., 6/8, Russia.
Bazhenova
E A
EA
Volkova
E A
EA
Alugishvili
M Z
MZ
Kiselev
I O
IO
Smirnov
B I
BI
Shvarts
E I
EI
Shliakhto
E V
EV
D000328:Adult; D005838:Genotype; D006801:Humans; D008297:Male; D016254:Mutagenesis, Insertional; D009203:Myocardial Infarction / Q000201:enzymology* / Q000401:mortality; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D017384:Sequence Deletion
D007703:Peptidyl-Dipeptidase A