Platelet 3H ketanserin binding in migraine.
Platelet 3H ketanserin binding was studied in 33 patients of migraine and 30 healthy controls. The binding characteristics: equilibrium dissociation constant (Kd) and maximal number of binding sites (Bmax) determined by Scatchard analysis revealed a significant decrease in Kd and no change in Bmax in migraine cases. No correlation was observed between the Kd and Bmax with the clinical features of migraine. The findings of the present study show that there is a decreased affinity of platelet 5-HT2 receptors in migraine.
Shukla
R
R
Department of Neurology, K.G.'s Medical College, Lucknow, India.
Khanna
V K
VK
Pradeep
S
S
Husain
M
M
Tandon
R
R
Nag
D
D
Dikshit
M
M
Srimal
R C
RC
Seth
P K
PK
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D007650:Ketanserin / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D011485:Protein Binding; D011985:Receptors, Serotonin / Q000097:blood* / Q000502:physiology; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000378:metabolism*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D012701:Serotonin; D007650:Ketanserin