title: Effect of chronic ethanol ingestion and exercise training on skeletal muscle in rat.
abstract: The aim of this study was to investigate the interactive effects of exercise training and chronic ethanol consumption on metabolism, capillarity, and myofibrillar composition in rat limb muscles. Male Wistar rats were treated in separate groups as follows: non exercised-control; ethanol (15%) in animals' drinking water for 12 weeks; exercise training in treadmill and ethanol administration plus exercise for 12 weeks. Ethanol administration decreased capillarity and increased piruvate kinase and lactate dehydrogenase activities in white gastrocnemius; in plantaris muscle, ethanol increased citrate synthase activity and decreased cross-sectional area of type I, IIa, and IIb fibres. Exercise increased capillarity in all four limb muscles and decreased type I fibre area in plantaris. The decreased capillarity effect induced by ethanol in some muscles, was ameliorated when alcohol was combined with exercise. While alcoholic myopathy affects predominantly type IIb fibres, ethanol administration and aerobic exercise in some cases can affect type I and type IIa fibre areas. The exercise can decrease some harmful effects produced by ethanol in the muscle, including the decrease in the fibre area and capillary density.
authors.affiliation: Department of Physiology, The University of León, 24071 León, Spain
authors.forename: L
authors.initials: L
authors.lastname: Vila
authors.forename: A
authors.initials: A
authors.lastname: Ferrando
authors.forename: J
authors.initials: J
authors.lastname: Voces
authors.forename: C
authors.initials: C
authors.lastname: Cabral de Oliveira
authors.forename: J G
authors.initials: JG
authors.lastname: Prieto
authors.forename: A I
authors.initials: AI
authors.lastname: Alvarez
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002196:Capillaries / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D018656:Muscle Fibers, Fast-Twitch / Q000378:metabolism / Q000648:ultrastructure; D009132:Muscles / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology*; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D013053:Spectrophotometry; D013997:Time Factors
chemical_list: D000431:Ethanol