Chronic inflammatory demyelinating polyneuropathy caused by HIV infection in a patient with asymptomatic CMT 1A.
It is well known that patients with Charcot-Marie-Tooth (CMT) disease are liable to present with episodes of cortisone-responsive demyelination, and a superimposed inflammatory component has been suggested. We report a patient who presented with a chronic inflammatory demyelinating polyneuropathy due to a recent HIV infection, which revealed a previously asymptomatic CMT 1A disease documented by identification of the characteristic duplication on the p11.2 region of chromosome 17. The inflammatory process was characterized by pathologic findings on a superficial peroneal nerve biopsy, and the patient improved significantly after corticotherapy. This report gives support to the hypothesis of a genetic susceptibility to inflammatory demyelinating processes in certain CMT kindreds.
Rajabally
Y
Y
Département de Neurologie, Centre Hospitalier du Haut-Levêque, Pessac-Bordeaux, France.
Vital
A
A
Ferrer
X
X
Vital
C
C
Julien
J
J
Latour
P
P
Vandenberghe
A
A
Lagueny
A
A
D000328:Adult; D001706:Biopsy; D002607:Charcot-Marie-Tooth Disease / Q000473:pathology* / Q000821:virology*; D015658:HIV Infections / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010543:Peroneal Nerve / Q000473:pathology / Q000648:ultrastructure; D020277:Polyradiculoneuropathy, Chronic Inflammatory Demyelinating / Q000473:pathology* / Q000821:virology*