title: A model of a segmental oscillator in the leech heartbeat neuronal network.
abstract: We modeled a segmental oscillator of the timing network that paces the heartbeat of the leech. This model represents a network of six heart interneurons that comprise the basic rhythm-generating network within a single ganglion. This model builds on a previous two cell model (Nadim et al., 1995) by incorporating modifications of intrinsic and synaptic currents based on the results of a realistic waveform voltage-clamp study (Olsen and Calabrese, 1996). Due to these modifications, the new model behaves more similarly to the biological system than the previous model. For example, the slow-wave oscillation of membrane potential that underlies bursting is similar in form and amplitude to that of the biological system. Furthermore, the new model with its expanded architecture demonstrates how coordinating interneurons contribute to the oscillations within a single ganglion, in addition to their role of intersegmental coordination.
authors.affiliation: Biology Department, Emory University, 1510 Clifton Road, Atlanta, GA 30322, USA. ahill@biology.emory.edu
authors.forename: A A
authors.initials: AA
authors.lastname: Hill
authors.forename: J
authors.initials: J
authors.lastname: Lu
authors.forename: M A
authors.initials: MA
authors.lastname: Masino
authors.forename: O H
authors.initials: OH
authors.lastname: Olsen
authors.forename: R L
authors.initials: RL
authors.lastname: Calabrese
mesh_terms: D000818:Animals; D004553:Electric Conductivity; D006329:Heart Conduction System / Q000502:physiology*; D006339:Heart Rate / Q000502:physiology*; D008955:Models, Cardiovascular; D008959:Models, Neurological; D009415:Nerve Net / Q000502:physiology*; D009991:Oscillometry; D011930:Reaction Time / Q000502:physiology; D013569:Synapses / Q000502:physiology