title: Lack of association between apolipoprotein E genoype and ischaemic stroke in a Scottish population.
abstract: BACKGROUND
  Apolipoprotein E epsilon4 allele has been associated with increased risk of coronary heart disease, and is also a major genetic susceptibility locus for Alzheimer's disease. Some studies have shown an association between apoE genotype and ischaemic stroke or outcome following stroke, while other studies have failed to do so. Materials and methods Using PCR and the Taqman fluorescence system to detect polymorphisms we examined apoE genotype in 266 ischaemic stroke cases and in a control population.
  
  
  RESULTS
  We found no association between apoeE epsilon 4 allele distribution and ischaemic stroke, or with outcome following stroke as measured using the Rankin score. Conclusion This study disagrees with a recent meta-analysis, and suggests that further studies are required to clarify the exact relationship between apoE genotype and ischaemic stroke.
authors.affiliation: University of Aberdeen, Aberdeen, UK. mmd275@abdn.ac.uk
authors.forename: M J
authors.initials: MJ
authors.lastname: MacLeod
authors.forename: R P
authors.initials: RP
authors.lastname: De Lange
authors.forename: G
authors.initials: G
authors.lastname: Breen
authors.forename: D
authors.initials: D
authors.lastname: Meiklejohn
authors.forename: H
authors.initials: H
authors.lastname: Lemmon
authors.forename: D S
authors.initials: DS
authors.lastname: Clair
mesh_terms: D000368:Aged; D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D002545:Brain Ischemia / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic; D012606:Scotland / Q000453:epidemiology; D020521:Stroke / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics
chemical_list: D001057:Apolipoproteins E