S15176 and S16950 interaction with Cyclosporin A antiproliferative effect on cultured human lymphocytes.
S15176 and S16950 are trimetazidine derivatives that antagonize more strongly than the parent drug mitochondrial toxicity, which leads to cellular hypoxia and nephrotoxicity in kidneys experimentally exposed to cyclosporin A. We have investigated whether every derivative might interact or not with the inhibitory effect of Cyclosporin A on the proliferation of cultured human lymphocytes. S15176 significantly increased the antilymphoproliferative effect of Cyclosporin A, whereas S15176 by itself neither displayed any antilymphoproliferative effect, nor did it induce any apoptotic process in cultured human lymphocytes. The effect of S16950 was not significant.
Albengres
E
E
Service Hospitalo-Universitaire de Pharmacologie, Faculté de Médecine, 8 Rue du Général Sarrail, F-94010 Créteil, France. edith.albengres@wanadoo.fr
Le Louët
H
H
d'Athis
P
P
Tillement
J P
JP
D000328:Adult; D000911:Antibodies, Monoclonal; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D016572:Cyclosporine / Q000097:blood / Q000494:pharmacology*; D053938:DNA Fragmentation; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008928:Mitochondria / Q000187:drug effects; D010879:Piperazines / Q000737:chemistry / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D014292:Trimetazidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D000975:Antioxidants; D007166:Immunosuppressive Agents; D010879:Piperazines; C416838:S 15176; C441048:S 16950; D016572:Cyclosporine; D014292:Trimetazidine; D002118:Calcium; D013936:Thymidine