title: Ion homeostasis and apoptosis.
abstract: Alterations in the transmembrane gradients of several physiological ions may influence programmed cell death. In particular, recent data suggest that increases in intracellular calcium may either promote or inhibit apoptosis, depending on the level, timing and location, whereas loss of intracellular potassium promotes apoptosis.
authors.affiliation: Center for the Study of Nervous System Injury and Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Missouri 63110, St. Louis, USA. yus@neuro.wustl.edu
authors.forename: S P
authors.initials: SP
authors.lastname: Yu
authors.forename: L M
authors.initials: LM
authors.lastname: Canzoniero
authors.forename: D W
authors.initials: DW
authors.lastname: Choi
mesh_terms: D000818:Animals; D017209:Apoptosis; D020013:Calcium Signaling; D048429:Cell Size; D018118:Chloride Channels / Q000502:physiology; D006706:Homeostasis; D017136:Ion Transport; D008954:Models, Biological; D011188:Potassium / Q000378:metabolism
chemical_list: D018118:Chloride Channels; D011188:Potassium