title: The role of n-6 polyunsaturated fat in stable asthmatics.
abstract: We investigated in a clinical setting whether increased intake of linoleic acid alters respiratory function in 26 mild asthmatics. Subjects completed a 16-week-dietary intervention comprising 8 weeks eating an enriched n-6 polyunsaturated fat diet (9.2% energy from linoleic acid) and consuming either a high monounsaturated or saturated fat diet in a random cross-over resign for 8 weeks. Neither FEV1 nor PC20 values changed significantly after increased linoleic acid consumption when compared with the other diets. Increased consumption of linoleic acid caused a 20% rise (p < or = 0.01) in plasma linoleic acid, a 38% decrease (p < or = 0.01) in plasma eicosapentaenoic acid, but no change in arachidonic acid. There were no changes in symptom scores or bronchodilator use.
authors.affiliation: Department of Physiology, University of Adelaide, SA, Australia.
authors.forename: A
authors.initials: A
authors.lastname: Morris
authors.forename: M
authors.initials: M
authors.lastname: Noakes
authors.forename: P M
authors.initials: PM
authors.lastname: Clifton
mesh_terms: D001249:Asthma / Q000097:blood / Q000178:diet therapy*; D018592:Cross-Over Studies; D005227:Fatty Acids / Q000097:blood; D005260:Female; D005541:Forced Expiratory Volume; D006632:Histamine; D006801:Humans; D019787:Linoleic Acid / Q000008:administration & dosage*; D008297:Male; D008383:Margarine; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate
chemical_list: D005227:Fatty Acids; D008383:Margarine; D006632:Histamine; D019787:Linoleic Acid