Wegener's granulomatosis: description of a case where cutaneous involvement was correlated with elevation of the c-ANCA titer.
Wegener's granulomatosis is a systemic disease characterized by necrotizing granulomas and vasculitis involving the upper and lower respiratory tract as well as the kidneys. Cutaneous manifestations consist mainly of papules or papulonecrotic lesions. c-ANCA are known to be a valuable adjunct for the diagnosis and follow-up of Wegener's granulomatosis with systemic involvement. We report the case of a 49-year-old man with Wegener's granulomatosis who developed two relapses of the disease with cutaneous manifestation and who presented with concomitant elevation of the c-ANCA and more precisely the subset PR3-ANCA during the acute phase of the disease.
Mock
M
M
Department of Dermatology, DHURDV, CHUV, Lausanne, Switzerland.
Cerottini
J P
JP
Derighetti
M
M
Buxtorf
K
K
Livio
F
F
Panizzon
R G
RG
D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D002081:Buttocks; D004550:Elbow; D014890:Granulomatosis with Polyangiitis / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007167:Immunotherapy; D007866:Leg; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012871:Skin Diseases / Q000473:pathology* / Q000628:therapy
D019268:Antibodies, Antineutrophil Cytoplasmic