Intraocular lens glucose sensor.
Ocular spectroscopy, which is the use of the eye to monitor optically the concentration of metabolites in the body, has been successfully applied to monitor aqueous humor glucose concentration. In the United States, 1.7 million intraocular lenses are currently implanted yearly. Because patients with diabetes are more likely to develop cataracts at an earlier age, a relatively high proportion of the patients receiving intraocular lenses have diabetes. Last year, 110,000 patients with diabetes received intraocular lens implants of various materials. We have successfully polymerized a fluorescent complex within a hydrogel intraocular lens that responds well to glucose concentration.
March
W F
WF
Department of Ophthalmology and Visual Sciences, University of Texas Medical Branch Galveston, 77550-1141, USA. wfmarch@yahoo.com
Ochsner
K
K
Horna
J
J
D000818:Animals; D001082:Aqueous Humor / Q000737:chemistry*; D002386:Cataract / Q000209:etiology; D002387:Cataract Extraction; D003208:Concanavalin A / Q000737:chemistry; D003911:Dextrans / Q000737:chemistry; D048909:Diabetes Complications; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000737:chemistry; D005453:Fluorescence; D005456:Fluorescent Dyes; D005947:Glucose / Q000032:analysis*; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000601:surgery; D011092:Polyethylene Glycols; D011108:Polymers; D011817:Rabbits; D012235:Rhodamines / Q000737:chemistry; D013050:Spectrometry, Fluorescence
D003911:Dextrans; D005456:Fluorescent Dyes; D011108:Polymers; D012235:Rhodamines; C015219:fluorescein isothiocyanate dextran; D003208:Concanavalin A; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; C009434:tetramethylrhodamine isothiocyanate; D016650:Fluorescein-5-isothiocyanate; D005947:Glucose