title: Continuous monitoring of ICP and CPP following ICH and its relationship to clinical, radiological and surgical parameters.
abstract: Sixty-two patients with a spontaneous supratentorial haemorrhage had continuous Intracranial Pressure (ICP) and Cerebral Perfusion Pressure (CPP) monitoring. In addition to the recordings of physiological data their past medical history, presenting neurological state, Computed Tomograph (CT) findings, daily Glasgow Coma Score (GCS) and outcome were noted. The mean age was 57.6 years (sd 13.3). Onset of recording, after ictus was at a mean of 32.6 hours (sd 26.0). Average length of recording was 62.0 hours (sd 39.8). Thirty-one patients had evacuation of haematoma, 6 insertion of External Ventricular Drain (EVD). Preoperative measures of ICP were significantly related to delayed neurological deterioration, death within three days and Glasgow Outcome Scale (GOS) at neurosurgical discharge. No such relationships existed with preoperative measures of CPP and neither ICP nor CPP was related to outcome at 6 months. Post-operative measures of both ICP and CPP demonstrated a significant relationship with death within three days of ictus and GOS at neurosurgical discharge. Again no relationship existed with these parameters and outcome at six months. Surgical evacuation of haematoma acted to significantly reduce ICP and improve CPP. Given that these factors seem to be related to deterioration, death and early outcome, it would seem that surgery could play a role in reducing mortality and improving outcome following Intra cerebral Haemorrhage (ICH).
authors.affiliation: Department of Neurosurgery, University of Newcastle upon Tyne, UK.
authors.forename: H M
authors.initials: HM
authors.lastname: Fernandes
authors.forename: S
authors.initials: S
authors.lastname: Siddique
authors.forename: K
authors.initials: K
authors.lastname: Banister
authors.forename: I
authors.initials: I
authors.lastname: Chambers
authors.forename: T
authors.initials: T
authors.lastname: Wooldridge
authors.forename: B
authors.initials: B
authors.lastname: Gregson
authors.forename: A D
authors.initials: AD
authors.lastname: Mendelow
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D001921:Brain / Q000098:blood supply*; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D015600:Glasgow Coma Scale; D023261:Glasgow Outcome Scale; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology*; D008991:Monitoring, Physiologic; D011183:Postoperative Complications / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology; D011379:Prognosis; D012039:Regional Blood Flow / Q000502:physiology; D015996:Survival Rate; D014057:Tomography, X-Ray Computed