title: Synthesis of a chiral aziridine derivative as a versatile intermediate for HIV protease inhibitors.
abstract: [reaction: see text] Chiral aziridine derivative 1 was prepared from D-tartaric acid. This compound could be utilized as a common intermediate for the synthesis of hydroxyethylamine class HIV protease inhibitors such as saquinavir, amprenavir, or nelfinavir.
authors.affiliation: Center for Molecular Catalysis, School of Chemistry & Molecular Engineering, Seoul National University, Seoul, 151-747, Korea. kimbm@snu.ac.kr
authors.forename: B M
authors.initials: BM
authors.lastname: Kim
authors.forename: S J
authors.initials: SJ
authors.lastname: Bae
authors.forename: S M
authors.initials: SM
authors.lastname: So
authors.forename: H T
authors.initials: HT
authors.lastname: Yoo
authors.forename: S K
authors.initials: SK
authors.lastname: Chang
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Kang
mesh_terms: D001388:Aziridines / Q000138:chemical synthesis*; D017320:HIV Protease Inhibitors / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013644:Tartrates / Q000737:chemistry
chemical_list: D001388:Aziridines; D017320:HIV Protease Inhibitors; D013644:Tartrates; C029768:tartaric acid