The implication of repeated versus continuous strain on nerve function in a rat forelimb model.
We studied the effect of repeated and continuous nerve strain using a rat forelimb model to investigate whether an innocuous level of strain applied continuously affects nerve function when applied repeatedly. We used the rat medial cord of the brachial plexus and assessed the effects of strain by studying nerve histology (blood-nerve barrier), function (grasping strength), and electrophysiology. Continuous stretching was applied to the rat forelimb for 1 hour at 2 N. After this strain neither histologic analysis, grasping strength, nor electrophysiologic analysis revealed any effect. We then applied repeated strain at both 60 and 120 times per hour; after the latter strain abnormalities in histology, grasping strength, and nerve conduction were identified. There results suggest that a small nerve strain applied repeatedly results in nerve dysfunction. Our data may help explain the cause of nonspecific neural symptoms in the upper extremities of patients with no objective findings.
Watanabe
M
M
Department of Orthopaedic Surgery, School of Medicine, Kumamoto University, Kumamoto, Japan.
Yamaga
M
M
Kato
T
T
Ide
J
J
Kitamura
T
T
Takagi
K
K
D000818:Animals; D001917:Brachial Plexus / Q000502:physiology*; D020516:Brachial Plexus Neuropathies / Q000503:physiopathology; D012090:Cumulative Trauma Disorders / Q000503:physiopathology*; D004594:Electrophysiology; D005552:Forelimb; D018737:Hand Strength; D023421:Models, Animal; D009431:Neural Conduction; D051381:Rats; D017208:Rats, Wistar; D013314:Stress, Mechanical