title: Gas transfer and blood compatibility of asymmetric polyimide hollow fiber.
abstract: We have fabricated an asymmetric polyimide hollow fiber for use as a membrane oxygenator. A dry/wet phase inversion process has been applied to a spinning process to prepare the hollow fiber. The fiber structure consisted of a complete defect-free skin layer and a porous substructure characterized by the presence of an open-cell structure and macrovoids. The outer diameter was 480 microm with a wall thickness of 50 microm. Transfer rates of O2 and CO2 in the asymmetric polyimide fiber were 2.3 x 10(-5) and 1.1 x 10(-4) (cm3 (STP)/(cm2 s cmHg)), respectively, which were four times higher than those measured in the polydimethylsiloxane (PDMS) fiber of the presently-available membrane oxygenator. The (QO2/QN2) selectivity of the polyimide fiber was 4.9, indicating that the surface skin layer is essentially defect-free. The blood compatibility of the polyimide hollow fiber has been evaluated in vitro and in vivo. The polyimide had an excellent blood compatibility when compared with PDMS.
authors.affiliation: Department of Applied Chemistry, Tokyo Metropolitan University, Hachioji, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Niwa
authors.forename: H
authors.initials: H
authors.lastname: Kawakami
authors.forename: M
authors.initials: M
authors.lastname: Kanno
authors.forename: S
authors.initials: S
authors.lastname: Nagaoka
authors.forename: T
authors.initials: T
authors.lastname: Kanamori
authors.forename: T
authors.initials: T
authors.lastname: Shinbo
authors.forename: S
authors.initials: S
authors.lastname: Kubota
mesh_terms: D000327:Adsorption; D000818:Animals; D001672:Biocompatible Materials / Q000737:chemistry* / Q000592:standards; D001798:Blood Proteins / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D004867:Equipment Design; D006801:Humans; D007094:Imides / Q000737:chemistry*; D008855:Microscopy, Electron, Scanning; D010100:Oxygen / Q000378:metabolism; D010107:Oxygenators, Membrane / Q000592:standards*; D010539:Permeability; D010973:Platelet Adhesiveness; D011108:Polymers / Q000737:chemistry*; D011817:Rabbits; D014684:Venae Cavae
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D007094:Imides; D011108:Polymers; D002245:Carbon Dioxide; D010100:Oxygen