title: Pulmonary fungal infection: emphasis on microbiological spectra, patient outcome, and prognostic factors.
abstract: OBJECTIVE
  To investigate the microbiological spectra, patient outcome, and prognostic factors of pulmonary fungal infection.
  
  
  METHODS
  The medical and microbiological records of patients with pulmonary fungal infection were retrospectively analyzed.
  
  
  METHODS
  A university-affiliated tertiary medical center.
  
  
  METHODS
  From January 1988 to December 1997, all cases of pulmonary fungal infection were reviewed. The criteria for inclusion were obvious lung lesion shown on chest radiographs and one of the following: (1) the presence of fungi in or isolation of fungi from the biopsy specimen of open thoracotomy, thoracoscopy, transbronchial lung biopsy, or ultrasound-guided percutaneous needle aspiration/biopsy; or (2) isolation of fungi from pleural effusion or blood, with no evidence of extrapulmonary infection.
  
  
  RESULTS
  A total of 140 patients were included. Ninety-four cases of pulmonary fungal infection (67%) were community acquired. The most frequently encountered fungi were Aspergillus species (57%), followed by Cryptococcus species (21%) and Candida species (14%). There were 72 patients with acute invasive fungal infection, with a mortality rate of 67%. Multivariate logistic regression analysis showed that nosocomial infection (p = 0.014) and respiratory failure (p = 0.001) were significantly and independently associated with death of acute invasive fungal infection.
  
  
  CONCLUSIONS
  Pulmonary fungal infection of community-acquired origins is becoming a serious problem. It should be taken into consideration for differential diagnosis of community-acquired pneumonia. Furthermore, acute invasive fungal infection is associated with a much higher mortality rate for patients with nosocomial infection or complicating respiratory failure. Early diagnosis with prompt antifungal therapy, or even with surgical intervention, might be warranted to save patients' lives.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.
authors.forename: K Y
authors.initials: KY
authors.lastname: Chen
authors.forename: S C
authors.initials: SC
authors.lastname: Ko
authors.forename: P R
authors.initials: PR
authors.lastname: Hsueh
authors.forename: K T
authors.initials: KT
authors.lastname: Luh
authors.forename: P C
authors.initials: PC
authors.lastname: Yang
mesh_terms: D000328:Adult; D003428:Cross Infection / Q000382:microbiology; D005260:Female; D005658:Fungi / Q000302:isolation & purification; D006801:Humans; D016867:Immunocompromised Host; D008172:Lung Diseases, Fungal / Q000175:diagnosis / Q000382:microbiology / Q000401:mortality / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012307:Risk Factors; D015996:Survival Rate; D016896:Treatment Outcome