Can [15O]water be used to evaluate drugs?
There is an extensive literature supporting the use of rCBF as a surrogate marker of local neuronal activity. This provides a strong physiologic rationale for using PET measurements of rCBF to study the effects of drugs acting on the brain. The ability to perform multiple brief measurements of rCBF with [15O]water in a single study session makes possible a wide variety of experimental designs. Numerous investigators have successfully applied the method to study a wide variety of centrally acting drugs. In summary, then, the answer to the question, "Can [15O]water be used to evaluate drugs?" is a definitive yes.
Herscovitch
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PET Department, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland, USA.
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D001923:Brain Chemistry; D004341:Drug Evaluation / Q000379:methods*; D006801:Humans; D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D014055:Tomography, Emission-Computed; D014867:Water / Q000378:metabolism
D010104:Oxygen Radioisotopes; D019275:Radiopharmaceuticals; D014867:Water