title: [Thermodynamic model of the formation of bridges between nucleic acid molecules in a liquid crystal].
abstract: A thermodynamic model of the formation of bridges consisting of alternating daunomycin molecules and copper ions and connecting neighboring nucleic acid molecules in a particle of a liquid crystalline dispersion was constructed. The model is based on the conception that ligands are adsorbed on lattices of reaction centers which are formed in a liquid crystal at a particular spatial arrangement of adjacent nucleic acid molecules (phasing). Equations were derived that describe typical experimentally obtained S-shaped dependences of bridge concentration on the concentration of copper ions and daunomycin molecules in an initial solution. It was shown that dependences of this kind take place in two variants of the adsorption model: when the binding of daunomycin with adjacent nucleic acid molecules is considered to be independent on the formation of bridges and when bridges compete with single daunomycin molecules for the sites on adjacent nucleic acid molecules.
authors.affiliation: Engelgardt Institute of Molecular Biology, Russian Academy of Sciences, ul. Vavilova 32, Moscow, 117984 Russia.
authors.forename: Iu D
authors.initials: IuD
authors.lastname: Nechipurenko
authors.forename: S A
authors.initials: SA
authors.lastname: Strel'tsov
authors.forename: Iu M
authors.initials: IuM
authors.lastname: Evdokimov
mesh_terms: D000465:Algorithms; D003300:Copper / Q000737:chemistry*; D003460:Crystallization; D003630:Daunorubicin / Q000737:chemistry*; D007477:Ions; D008024:Ligands; D008956:Models, Chemical; D009696:Nucleic Acids / Q000737:chemistry*; D013816:Thermodynamics
chemical_list: D007477:Ions; D008024:Ligands; D009696:Nucleic Acids; D003300:Copper; D003630:Daunorubicin