Dehydration of hydroxenin monoacetate in the presence of ultrasound.
Starting from hydroxenin monoacetate, vitamin A acetate is obtained in a E/Z mixture by dehydration. This result could be explained by the formation of a small amount of hydrochloric acid from trichloromethane under ultrasound irradiation and based on further experiments.
Aquino
F
F
F. Hoffmann-LaRoche Ltd., Vitamins and Fine Chemicals Division, Grenzacherstrasse 124, CH-4070 Basel, Switzerland.
Bonrath
W
W
D006851:Hydrochloric Acid / Q000737:chemistry; D007536:Isomerism; D010777:Photochemistry; D012176:Retinoids / Q000138:chemical synthesis*; D014465:Ultrasonics; D014801:Vitamin A / Q000737:chemistry
D012176:Retinoids; C431467:hydroxenin monoacetate; D014801:Vitamin A; D006851:Hydrochloric Acid