Concurrent upregulation of urokinase plasminogen activator receptor and CD11b during tuberculosis and experimental endotoxemia.
Patients with tuberculosis had higher expression of monocyte urokinase receptor (uPAR) and CD11b than controls. In vitro, lipoarabinomannan and lipopolysaccharide (LPS) from Escherichia coli shared the ability to enhance uPAR and CD11b expression on monocytes and granulocytes. In healthy volunteers, LPS induced increases in monocyte and granulocyte uPAR and CD11b.
Juffermans
N P
NP
Laboratory of Experimental Internal Medicine, Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Dekkers
P E
PE
Verbon
A
A
Speelman
P
P
van Deventer
S J
SJ
van der Poll
T
T
D000328:Adult; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D006098:Granulocytes / Q000187:drug effects / Q000276:immunology; D006801:Humans; D008070:Lipopolysaccharides / Q000008:administration & dosage / Q000276:immunology* / Q000494:pharmacology; D016177:Macrophage-1 Antigen / Q000096:biosynthesis*; D008297:Male; D009000:Monocytes / Q000187:drug effects / Q000276:immunology; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D055293:Receptors, Urokinase Plasminogen Activator; D014376:Tuberculosis / Q000276:immunology*; D015854:Up-Regulation / Q000276:immunology
D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D016177:Macrophage-1 Antigen; C524898:PLAUR protein, human; D011956:Receptors, Cell Surface; D055293:Receptors, Urokinase Plasminogen Activator; C050016:lipoarabinomannan