title: [Blood plasma level of insulin and sensitivity to it in tissues of patients with newly detected diabetes mellitus type II].
abstract: Type II diabetes mellitus is the most common type of the condition. But little is yet known about mechanisms responsible for its development in persons with different body masses. We studied blood plasma levels of insulin and assessed sensitivity to it in 32 patients with freshly detected type II diabetes mellitus with normal and above normal body weight. Of these, 20 subjects were obese, the other 12 being not fat; the control group comprised 30 persons obese and non-obese, with n = 15 and 15 respectively. Recordable in patients was a marked elevation of blood plasma level of insulin accompanied by decrement of the peripheral tissue sensitivity to it in obese diabetic patients while in those persons with normal body mass there was a substantial reduction in the production of insulin, which differences may indicate different pathogenesis of development of type II diabetes mellitus in persons with different body masses.
authors.forename: V A
authors.initials: VA
authors.lastname: Lysenko
authors.forename: B N
authors.initials: BN
authors.lastname: Man'kovskiĭ
authors.forename: V V
authors.initials: VV
authors.lastname: Popova
mesh_terms: D015992:Body Mass Index; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005215:Fasting; D006801:Humans; D007328:Insulin / Q000097:blood*; D007333:Insulin Resistance; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000150:complications
chemical_list: D007328:Insulin