title: Membrane traffic: how do GGAs fit in with the adaptors?
abstract: The AP-1 adaptor complex has been cast as the major player in clathrin coat formation for vesicular transport from the trans-Golgi to the endocytic pathway. But new results on 'GGA' proteins have raised doubts about this paradigm and suggest both a new sorting mechanism and an unexpected complexity in the roles of clathrin.
authors.affiliation: MRC-Laboratory of Molecular Biology, Hills Road, CB2 2QH, Cambridge, UK.
authors.forename: M W
authors.initials: MW
authors.lastname: Black
authors.forename: H R
authors.initials: HR
authors.lastname: Pelham
mesh_terms: D020823:ADP-Ribosylation Factor 1 / Q000378:metabolism; D020727:ADP-Ribosylation Factors / Q000378:metabolism*; D033942:Adaptor Proteins, Vesicular Transport; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002966:Clathrin / Q000378:metabolism*; D022163:Clathrin-Coated Vesicles / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D011487:Protein Conformation; D021381:Protein Transport / Q000502:physiology*; D018808:Transcription Factor AP-1 / Q000378:metabolism
chemical_list: D033942:Adaptor Proteins, Vesicular Transport; D002352:Carrier Proteins; D002966:Clathrin; C407306:GGA adaptor proteins; D018808:Transcription Factor AP-1; D020823:ADP-Ribosylation Factor 1; D020727:ADP-Ribosylation Factors