[Relationship between lymphatic metastasis in breast and cervix cancers and the level of CD44-H expression evaluated by an immunohistochemical method].
Immunohistochemistry has been used to evaluate the relationship between the rate of CD44-H antigen expression in breast invasive intracanalicuar and cervical epidermoïd carcinomas and the presence of node metastasis. A total of 36 cases of breast carcinoma and 20 cases of cervical carcinoma was examined. For the two types of carcinoma, the CD44-H molecule was highly expressed in cases with node metastasis; with 50% and 75% median value of CD44-H positive tumor cells respectively for the breast (p < 0.02) and for the uterine cervix (p < 0.05) compared to respectively 10% and 37.5% in the cases without node metastasis. The expression of this molecule increases with invasive potential of tumor cells and the use of this antigen for prognostic ends may be possible.
Yahyaoui
O
O
Laboratoire d'histologie, faculté de médecine et de pharmacie, université Hassan II, 19, rue Tarik Ibn Ziad, Casablanca, Maroc.
Guerbaoui
M
M
Oudghiri
M
M
D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000276:immunology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology; D004396:Coloring Agents; D005260:Female; D006801:Humans; D018960:Hyaluronan Receptors / Q000032:analysis*; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D010503:Periodic Acid-Schiff Reaction; D002583:Uterine Cervical Neoplasms / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D004396:Coloring Agents; D018960:Hyaluronan Receptors