Protein structure prediction methods for drug design.
Along the long path from genomic data to a new drug, the knowledge of three-dimensional protein structure can be of significant help in several places. This paper points out such places, discusses the virtues of protein structure knowledge and reviews bioinformatics methods for gaining such knowledge on the protein structure.
Lengauer
T
T
Institute for Algorithms and Scientific Computing, GMD, National Research Center for Information Technology, Sankt Augustin, Germany. lengauer@gmd.de
Zimmer
R
R
D019295:Computational Biology; D003198:Computer Simulation; D017076:Computer-Aided Design; D015195:Drug Design; D015394:Molecular Structure; D011506:Proteins / Q000737:chemistry* / Q000502:physiology; D016415:Sequence Alignment; D012984:Software
D011506:Proteins