title: Abnormal signals on proton density-weighted MRI of the superior cerebellar peduncle in progressive supranuclear palsy.
abstract: OBJECTIVE
  To assess MRI signal abnormalities of the superior cerebellar peduncle (SCP) in progressive supranuclear palsy (PSP) patients.
  
  
  METHODS
  Signal changes were examined on proton density-weighted images (PDWI) and on T2-weighted images (T2WI) of SCP in 9 PSP patients, and findings were compared to those in 20 Parkinson's disease patients and 20 age-matched control subjects.
  
  
  RESULTS
  We observed effacement or lack of clarity of the low signal on PDWI in SCP in 4 of 9 PSP patients, but not in any of the Parkinson's disease patients or control subjects. These signal changes were not observed on T2WI.
  
  
  CONCLUSIONS
  The signal changes on PDWI may be a specific finding reflecting demyelination and gliosis of SCP in PSP. Our findings suggest that evaluation of SCP on PDWI may be helpful in the diagnosis of PSP patients.
authors.affiliation: Third Department of Internal Medicine, Hiroshima University School of Medicine 1-2-3 Kasumi, Minami-ku, Hiroshima 734-8551, Japan. okamasak@radi.med.hokudai.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: S
authors.initials: S
authors.lastname: Katayama
authors.forename: Y
authors.initials: Y
authors.lastname: Imon
authors.forename: T
authors.initials: T
authors.lastname: Ohshita
authors.forename: Y
authors.initials: Y
authors.lastname: Mimori
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D002531:Cerebellum / Q000473:pathology*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011522:Protons; D012189:Retrospective Studies; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000473:pathology*
chemical_list: D011522:Protons