Topographic distribution and developmental timecourse of auditory event-related potentials in two subtypes of attention-deficit hyperactivity disorder.
The effect of age on the topographic distribution of auditory event-related potentials (ERPs) recorded during a two-tone discrimination, or oddball, task was examined in two subtypes of attention deficit/hyperactivity disorder (AD/HD) as defined by the most recent diagnostic manual, DSM-IV. EEG was recorded at 17 sites from AD/HD predominantly inattentive type (n=50) and AD/HD combined type (n=50) subjects aged from 8 to 17 years 11 months. ERP components were quantified at each site. Results revealed topographic differences from controls (n=50) that were common to both subtypes (e.g. target and standard P2 amplitude, and standard P2 latency) or unique to a particular subtype of AD/HD (Inattentive type: target N1, N2, P3b and standard N2 amplitude, target P2 latency; Combined type: target N1, P2, N2 and P3b amplitude, target N2 and standard N1 latency). These group differences showed different age effects. The across-region results revealed differing patterns of abnormal component development for each subtype, indicating a qualitative difference in information processing stage deficits in each of these AD/HD subtypes.
Johnstone
S J
SJ
Department of Psychology, University of Wollongong, Northfields Avenue, Wollongong NSW 2522, Australia. stuart_johnstone@uow.edu.au
Barry
R J
RJ
Anderson
J W
JW
D000161:Acoustic Stimulation; D000293:Adolescent; D000375:Aging / Q000502:physiology; D001289:Attention Deficit Disorder with Hyperactivity / Q000503:physiopathology*; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D002648:Child; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology