title: Pacinian corpuscle in the human pancreas.
abstract: During our systematic examination of the distribution of cytochrome P450 enzymes in the normal and diseased human pancreas, we observed a Pacinian corpuscle in a serial section of a tissue from a pancreatic cancer patient. We report the histologic and immunohistochemical patterns in this corpuscle and review the literature. The Pacinian corpuscle was situated within the pancreas of a 76-year-old woman with cancer in the head of the pancreas. We could demonstrate immunoreactivity within the corpuscle for the neurofilament protein. neuron-specific enolase, S-100 Protein, and for four cytochrome P450-isozymes. The possible function of Pacinian corpuscles in the mammalian and human pancreas is discussed.
authors.affiliation: UNMC Eppley Cancer Center, University of Nebraska Medical Center, Omaha 68198-6805, USA.
authors.forename: J
authors.initials: J
authors.lastname: Standop
authors.forename: A
authors.initials: A
authors.lastname: Ulrich
authors.forename: M B
authors.initials: MB
authors.lastname: Schneider
authors.forename: A
authors.initials: A
authors.lastname: Andrén-Sandberg
authors.forename: P M
authors.initials: PM
authors.lastname: Pour
mesh_terms: D000368:Aged; D015415:Biomarkers; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007527:Isoenzymes / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D016900:Neurofilament Proteins / Q000032:analysis; D010141:Pacinian Corpuscles / Q000737:chemistry / Q000648:ultrastructure*; D010179:Pancreas / Q000294:innervation*; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D013045:Species Specificity
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D009419:Nerve Tissue Proteins; D016900:Neurofilament Proteins; D009418:S100 Proteins; D003577:Cytochrome P-450 Enzyme System; D010751:Phosphopyruvate Hydratase