title: [Selective cyclooxygenase 2 inhibitors (COX-2)].
abstract: Cyclooxygenase is key enzyme in the prostaglandin synthesis. It exists in two isoforms, which have distinct functions in the organism. Cyclooxygenase-2 (COX-2) participates in the pathophysiology of inflammation. Differences in the molecular structure of cyclooxygenases allowed to develop drug that selectively inhibit that isoform. Recently, selective inhibitors of COX-2 were introduced into therapy, providing new opportunities to the treatment of inflammation.
authors.affiliation: Klinika Pulmonologii, II Katedra Chorób Wewnetrznych Collegium Medicum UJ w Krakowie.
authors.forename: F
authors.initials: F
authors.lastname: Mejza
authors.forename: E
authors.initials: E
authors.lastname: Nizankowska
mesh_terms: D000068579:Celecoxib; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000627:therapeutic use*; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000235:genetics; D007783:Lactones / Q000494:pharmacology; D000077239:Meloxicam; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry / Q000235:genetics; D020033:Protein Isoforms; D011720:Pyrazoles; D013449:Sulfonamides / Q000494:pharmacology; D013450:Sulfones; D013843:Thiazines / Q000494:pharmacology; D013844:Thiazoles / Q000494:pharmacology
chemical_list: D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D007783:Lactones; D008565:Membrane Proteins; D020033:Protein Isoforms; D011720:Pyrazoles; D013449:Sulfonamides; D013450:Sulfones; D013843:Thiazines; D013844:Thiazoles; C116926:rofecoxib; D051545:Cyclooxygenase 1; D051546:Cyclooxygenase 2; C496511:PTGS1 protein, human; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases; D000068579:Celecoxib; C012655:nimesulide; D000077239:Meloxicam