The total synthesis of lipid I.
A total synthesis of lipid I (4), a membrane-associated intermediate in the bacterial cell wall (peptidoglycan) biosynthesis pathway, is reported. This highly convergent synthesis will enable further studies on bacterial resistance mechanisms and may provide insight toward the development of new chemotherapeutic agents with novel modes of action.
VanNieuwenhze
M S
MS
Discovery Chemistry Research and Chemical Process Research and Development, Lilly Research Laboratories, A Division of Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana 46285, USA.
Mauldin
S C
SC
Zia-Ebrahimi
M
M
Aikins
J A
JA
Blaszczak
L C
LC
D006094:Gram-Positive Bacteria / Q000737:chemistry; D009005:Monosaccharides / Q000138:chemical synthesis*; D009842:Oligopeptides / Q000138:chemical synthesis*; D010457:Peptidoglycan / Q000096:biosynthesis*; D014538:Uridine Diphosphate N-Acetylmuramic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis*
D009005:Monosaccharides; D009842:Oligopeptides; D010457:Peptidoglycan; D014538:Uridine Diphosphate N-Acetylmuramic Acid; C438940:lipid I; C002225:UDP-N-acetylmuramic acid pentapeptide