[Medicinal and chemical approaches to focused search of agents for treatment and therapy of Alzheimer disease].
The analysis and justification of medicinal chemistry approaches for focused search of novel agents for Alzheimer's disease (AD) and related disorders treatment and prevention have been reviewed. The systematization of modern biochemical and structural date related to the action of physiologically active compounds on the nervous system apparatus engaged in the AD-like disorders pathogenesis was performed. The major attention was paid to the cholinomimetic, anti-amyloid and antimetabolic approaches, basing on the results published in scientific literature in 3-4 last years and results of preclinical and clinical trials, presented in the internet database in the fall of 2000.
Bachurin
S O
SO
Institute of Physiologically Active Compounds, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russia. bachurin@ipac.ac.ru
D000109:Acetylcholine / Q000378:metabolism; D000544:Alzheimer Disease / Q000188:drug therapy* / Q000378:metabolism; D016229:Amyloid beta-Peptides / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000893:Anti-Inflammatory Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D000975:Antioxidants / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D017209:Apoptosis; D002118:Calcium / Q000037:antagonists & inhibitors; D018678:Cholinergic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology / Q000627:therapeutic use; D018846:Excitatory Amino Acids / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D008024:Ligands; D008928:Mitochondria / Q000187:drug effects; D018696:Neuroprotective Agents / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D016229:Amyloid beta-Peptides; D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D018678:Cholinergic Agents; D002800:Cholinesterase Inhibitors; D018846:Excitatory Amino Acids; D008024:Ligands; D018696:Neuroprotective Agents; D000109:Acetylcholine; D002118:Calcium