Cardiovascular and renal responses to a high-fat diet in Osborne-Mendel rats.
This study examined the cardiovascular, renal, and hormonal responses of dietary-induced obesity in Osborne-Mendel (OM) rats. Male OM rats were fed either a low (LF; n = 10)- or high-fat (HF; n = 11) diet for 17 wk. During week 15 of the study, arterial pressure was measured directly, 24 h/day, from chronically indwelling catheters. Body and kidney weights were 46 +/- 5 and 33 +/- 5% greater, respectively, in rats fed HF vs. LF diet. Left and right ventricular weights were also greater in rats fed HF diet (21 +/- 7 and 36 +/- 6%, respectively). Direct measurement of arterial pressure revealed only a slight increase in mean arterial pressure (88 +/- 1 in rats fed HF diet vs. 85 +/- 1 mmHg in rats fed LF diet), whereas there was no difference in resting heart rate between the two groups. Consumption of HF diet was also associated with a 3.5-fold increase in plasma insulin, a 16 +/- 4% higher blood glucose, and a 40 +/- 6% reduction in plasma renin activity compared with LF-fed rats. Thus feeding OM rats HF diet led to obesity, cardiac and renal hypertrophy, and hyperinsulinemia but only a slight increase in mean arterial pressure.
Fitzgerald
S M
SM
Department of Physiology and Biophysics, University of Mississippi Medical Center, 2500 North State St., Jackson, MS 39216-4505, USA.
Henegar
J R
JR
Brands
M W
MW
Henegar
L K
LK
Hall
J E
JE
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001835:Body Weight; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006439:Hemodynamics / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000097:blood; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009765:Obesity / Q000503:physiopathology*; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood; D014556:Urine / Q000737:chemistry
D001786:Blood Glucose; D004041:Dietary Fats; D007328:Insulin; D012083:Renin