title: In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines.
abstract: The alkaloidic fraction of the methanol extract of Peganum harmala seeds was tested in vitro on three tumoral cell-lines: UCP-Med and Med-mek carcinoma, and UCP-Med sarcoma. Proliferation was significantly reduced at all tested concentrations (20-120 micrograms/ml) during the first 24 h of contact. A cell lysis effect occurred after 24 h and increased thereafter to complete cell death within 48-72 h, depending on tested concentration.
authors.affiliation: Laboratoire de Pharmacologie et Toxicologie, Faculté de Medecine et de Pharmacie B.P. 6203 Rabat Instituts, Rabat, Morocco.
authors.forename: F
authors.initials: F
authors.lastname: Lamchouri
authors.forename: A
authors.initials: A
authors.lastname: Settaf
authors.forename: Y
authors.initials: Y
authors.lastname: Cherrah
authors.forename: M
authors.initials: M
authors.lastname: Hassar
authors.forename: M
authors.initials: M
authors.lastname: Zemzami
authors.forename: N
authors.initials: N
authors.lastname: Atif
authors.forename: E B
authors.initials: EB
authors.lastname: Nadori
authors.forename: A
authors.initials: A
authors.lastname: Zaid
authors.forename: B
authors.initials: B
authors.lastname: Lyoussi
mesh_terms: D000470:Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D019685:Rosales; D012639:Seeds; D014407:Tumor Cells, Cultured / Q000187:drug effects
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts