title: Statistical inference for the area under the receiver operating characteristic curve in the presence of random measurement error.
abstract: The area under the receiver operating characteristic curve is the most commonly used measure of the ability of a biomarker to distinguish between two populations. Some markers are subject to substantial measurement error. Under normality assumptions, the authors develop a confidence interval procedure for the area under the receiver operating characteristic curve that adjusts for measurement error. This procedure assumes the availability of data from a reliability study of the biomarker. A simulation study was used to check the validity of the proposed confidence interval. Furthermore, it was shown that not adjusting for measurement error could result in a serious understatement of the effectiveness of the biomarker.
authors.affiliation: Department of Social and Preventive Medicine, University at Buffalo, Buffalo, NY, USA. schistermane@cshs.org
authors.forename: E F
authors.initials: EF
authors.lastname: Schisterman
authors.forename: D
authors.initials: D
authors.lastname: Faraggi
authors.forename: B
authors.initials: B
authors.lastname: Reiser
authors.forename: M
authors.initials: M
authors.lastname: Trevisan
mesh_terms: D000704:Analysis of Variance; D015982:Bias; D015415:Biomarkers / Q000097:blood; D016001:Confidence Intervals; D003627:Data Interpretation, Statistical; D005260:Female; D005609:Free Radicals / Q000097:blood; D006801:Humans; D008297:Male; D012372:ROC Curve; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism
chemical_list: D015415:Biomarkers; D005609:Free Radicals; D017392:Thiobarbituric Acid Reactive Substances