title: Correlation between lead exposure indicators and sister chromatid exchange (SCE) frequencies in lymphocytes from inorganic lead exposed workers.
abstract: Inorganic lead exposure was studied in 31 volunteers employed in storage battery plant. The genotoxicity of lead was measured in terms of sister chromatid exchange (SCE). Erythrocyte delta-aminolevulinic acid dehydrogenase (ALAD) activity, urinary delta-aminolevulinic acid (U-ALA), and blood lead levels (PbBs) were also determined to evaluate some possible relations between these lead exposure indicators and the observed SCE frequencies. Blood lead concentration of 36.31 microg/dl was determined as an average level in the workers. Consequently decreased ALAD activity in erythrocytes and increased U-ALA excretion was observed in statistically higher PbBs when compared with the control group. A statistically significant correlation was observed between the PbBs and SCE frequencies (p < 0.05). Moreover, the correlation between U-ALA excretion and SCE frequencies (p < 0.01) was relatively higher than the correlation between PbBs and SCE frequencies. These results might indicate a possible mechanism of ALA mediation in the genotoxic effects of lead.
authors.affiliation: University of Ankara, Faculty of Pharmacy, Department of Toxicology, 06100, Tandogan, Ankara, Turkey. duydu@pharmacy.ankara.edu.tr
authors.forename: Y
authors.initials: Y
authors.lastname: Duydu
authors.forename: H S
authors.initials: HS
authors.lastname: Süzen
authors.forename: A
authors.initials: A
authors.lastname: Aydin
authors.forename: O
authors.initials: O
authors.lastname: Cander
authors.forename: H
authors.initials: H
authors.lastname: Uysal
authors.forename: A
authors.initials: A
authors.lastname: Işimer
authors.forename: N
authors.initials: N
authors.lastname: Vural
mesh_terms: D000328:Adult; D000622:Aminolevulinic Acid / Q000378:metabolism; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000097:blood; D006801:Humans; D007854:Lead / Q000009:adverse effects* / Q000097:blood; D008214:Lymphocytes; D008297:Male; D016273:Occupational Exposure; D000623:Porphobilinogen Synthase / Q000187:drug effects / Q000378:metabolism; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D004785:Environmental Pollutants; D007854:Lead; D000622:Aminolevulinic Acid; D000623:Porphobilinogen Synthase