title: Dopamine D5 receptor gene polymorphism and the risk of levodopa-induced motor fluctuations in patients with Parkinson's disease.
abstract: Motor fluctuations are the most common complication of levodopa therapy for Parkinson's disease (PD). Genetic factors could play a role in determining the occurrence of motor fluctuations. To investigate whether dopamine receptor D5 (DRD5) T978C polymorphism is associated with the risk of developing motor fluctuations in PD, we studied this polymorphism in a case-control study of 120 subjects with sporadic PD and 110 control subjects. We found that the overall allelic and genotypic frequencies did not differ significantly between patients with PD and control subjects (all P>0.7), and between motor fluctuators (n=50) and non-motor fluctuators (n=50) (all P>0.8). It suggests that DRD5 T978C polymorphism is not associated with the susceptibility to PD, nor with the risk of developing motor fluctuations in PD. Therefore, other polymorphisms that alter the expression of the dopamine receptors should be further studied.
authors.affiliation: Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University of Medical Sciences, 510080, Guangzhou, China. jianwang@fudan.edu
authors.forename: J
authors.initials: J
authors.lastname: Wang
authors.forename: Z L
authors.initials: ZL
authors.lastname: Liu
authors.forename: B
authors.initials: B
authors.lastname: Chen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000978:Antiparkinson Agents / Q000009:adverse effects*; D004252:DNA Mutational Analysis; D005260:Female; D005787:Gene Frequency; D005820:Genetic Testing; D005838:Genotype; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy* / Q000235:genetics* / Q000503:physiopathology; D011110:Polymorphism, Genetic / Q000187:drug effects / Q000235:genetics*; D017447:Receptors, Dopamine D1 / Q000187:drug effects* / Q000235:genetics* / Q000378:metabolism; D050641:Receptors, Dopamine D5; D012307:Risk Factors
chemical_list: D000978:Antiparkinson Agents; C493605:DRD5 protein, human; D017447:Receptors, Dopamine D1; D050641:Receptors, Dopamine D5; D007980:Levodopa