Ondansetron attenuates CCK induced satiety and c-fos labeling in the dorsal medulla.
Serotonin 5-HT(3) antagonists have been suggested for treatment of several disorders involving altered gastrointestinal (GI) function. CCK also has well documented GI actions on both food intake and vago-vagal reflexes. To evaluate potential interactions, the effect of a 5-HT(3) antagonist, ondansetron, on exogenous CCK induced satiety and c-fos activation was determined. Ondansetron reduced both actions of CCK by approximately 50%. The reduction in c-fos was localized to a specific subregion of the dorsal medulla, suggesting that a distinct subpopulation of CCK receptive fibers are modulated by 5-HT(3) ligands. Treatments using 5-HT(3) antagonists also may affect endogenous CCK functions.
Daughters
R S
RS
Division of Neuroscience Research, MMC 392, Department of Psychiatry, University of Minnesota Medical School, 420 Delaware Street, Minneapolis, MN 55455, USA.
Hofbauer
R D
RD
Grossman
A W
AW
Marshall
A M
AM
Brown
E M
EM
Hartman
B K
BK
Faris
P L
PL
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002766:Cholecystokinin / Q000096:biosynthesis* / Q000494:pharmacology*; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects*; D007150:Immunohistochemistry; D008024:Ligands; D008297:Male; D008954:Models, Biological; D017294:Ondansetron / Q000494:pharmacology*; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012702:Serotonin Antagonists / Q000494:pharmacology
D008024:Ligands; D016760:Proto-Oncogene Proteins c-fos; D012702:Serotonin Antagonists; D017294:Ondansetron; D002766:Cholecystokinin