title: Polychlorinated biphenyls (PCBs) and neurological development in children: a systematic review.
abstract: BACKGROUND
  Polychlorinated biphenyls (PCBs) are complex mixtures of persistent contaminants that are widespread in the environment. Newborns are exposed across the placenta and through breast feeding. Experimental animal studies have indicated that PCBs are neurotoxic. The neurological effects of these compounds on children are not clear.
  
  
  METHODS
  A systematic review of literature on the relation between neurological development in children and exposure to polychlorinated biphenyls.
  
  
  RESULTS
  Seven follow up studies evaluated the effect of prenatal exposure to PCBs. Two of these studies evaluated highly exposed children. In newborns, an increase of the abnormal reflexes was observed in all four studies evaluating it. During the first months of life, a decrease in motor skills was observed in four of the five studies that investigated psychomotor development; deficits in the acquisition of cognitive skills were observed only in one study assessing non-highly exposed populations. At 4 years of age, an effect on the cognitive areas was observed in four of the five studies that evaluated it. Postnatal exposure to PCBs through breast feeding was not clearly related to any effect on neurological development.
  
  
  CONCLUSIONS
  These studies suggest a subtle adverse effect of prenatal PCBs exposure on child neurodevelopment. Differences in study design, inconsistency in some of the results, and the lack of adequate quantitative exposure data, do not allow the derivation of the degree of risk associated with neurodevelopmental effects at current levels of exposure.
authors.affiliation: Respiratory and Environmental Health Research Unit, Institut Municipal d'Investigació Mèdica, Barcelona, Spain. nribas@imim.es
authors.forename: N
authors.initials: N
authors.lastname: Ribas-Fitó
authors.forename: M
authors.initials: M
authors.lastname: Sala
authors.forename: M
authors.initials: M
authors.lastname: Kogevinas
authors.forename: J
authors.initials: J
authors.lastname: Sunyer
mesh_terms: D001942:Breast Feeding / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003072:Cognition Disorders / Q000139:chemically induced; D002658:Developmental Disabilities / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018811:Maternal Exposure / Q000009:adverse effects; D008431:Maternal-Fetal Exchange; D019957:Motor Skills Disorders / Q000139:chemically induced; D011078:Polychlorinated Biphenyls / Q000009:adverse effects*; D011247:Pregnancy; D011596:Psychomotor Disorders / Q000139:chemically induced
chemical_list: D011078:Polychlorinated Biphenyls