title: Papillary thyroid carcinoma of the thyroglossal duct cyst: comparative cytohistologic and immunochemical study of 2 new cases and review of the literature.
abstract: We report a cytohistologic and immunohistochemical study of 2 cases of papillary thyroid carcinoma occurring in a thyroglossal duct cyst. The patients were a 21-year-old woman and a 48-year-old man. Needle aspiration cytology smears were consistent with papillary thyroid carcinoma. The Sistrunk procedure was done. Papillary carcinoma was found within a thyroglossal duct cyst. In 1 case, the tumor spread outside the cyst. Follow-up was uneventful in both patients (2 and 9 years, respectively). Our results would indicate that papillary carcinoma of thyroglossal duct cyst, though indistinguishable from its thyroid homologue, has a more indolent course and could therefore be singled out as a clinicopathologic entity. Needle aspiration cytology reliably assists in planning patient management.
authors.affiliation: Division of Anatomic Pathology, City Hospital, Conegliano TV, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Falconieri
authors.forename: D
authors.initials: D
authors.lastname: Della Libera
authors.forename: M
authors.initials: M
authors.lastname: Zanella
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness / Q000473:pathology; D013955:Thyroglossal Cyst / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D013964:Thyroid Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology* / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D014408:Biomarkers, Tumor