The frissonnant mutant mouse, a model of dopamino-sensitive, inherited motor syndrome.
The frissonnant (fri) mutation is an autosomic recessive mutation which spontaneously appeared in the stock of C3H mice. fri mutant mice have locomotor instability and rapid tremor. Since tremor ceases when mutant mice have sleep or are anaesthetized, and because of their obvious stereotyped motor behavior, these mice could represent an inherited Parkinsonian syndrome. We show here that the fri/fri mouse fulfills two out of the three criteria required to validate an experimental model of human disease, that is isomorphism, homology and predictivity. Indeed, fri/fri mice present an important motor deficit accompanying visible tremor and stereotypies. They display some memory deficits as in human Parkinson's desease. l-Dopa and apomorphine (dopaminergic agonists), ropinirole (selective D2 agonist), and selegiline (an monoamino-oxidase B [MAO-B] inhibitor) improve their clinical status. However, neither anatomopathological evidence of nigrostriatal lesion, nor decrease in tyrosine hydroxylase production could be seen.
Callizot
N
N
Faculté de Pharmacie, Laboratoire de Pathologie des Communications entre Cellules Nerveuses et Musculaires, Université Louis Pasteur, UPRES 2308, BP 24, Illkirch Cedex, F-67401, France.
Guénet
J L
JL
Baillet
C
C
Warter
J M
JM
Poindron
P
P
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003342:Corpus Striatum / Q000166:cytology; D004195:Disease Models, Animal; D004576:Electromyography; D005260:Female; D005808:Genes, Recessive; D007150:Immunohistochemistry; D007211:Indoles / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008569:Memory Disorders / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology; D051379:Mice; D008809:Mice, Inbred C3H; D008818:Mice, Neurologic Mutants; D009043:Motor Activity / Q000187:drug effects; D009474:Neurons / Q000201:enzymology; D010302:Parkinson Disease, Secondary / Q000188:drug therapy / Q000235:genetics / Q000503:physiopathology*; D004856:Postural Balance / Q000187:drug effects; D012642:Selegiline / Q000494:pharmacology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis / Q000096:biosynthesis
D000978:Antiparkinson Agents; D007211:Indoles; C046649:ropinirole; D012642:Selegiline; D007980:Levodopa; D014446:Tyrosine 3-Monooxygenase; D001058:Apomorphine