Nicotine inhibits estrogen response element binding in the rat brain.
General injection of nicotine induced an immediate and marked inhibition of estrogen response element (ERE) binding in the rat brain. Either mecamylamine or nifedipine fully antagonized the ERE binding-inhibiting effect of nicotine.
Shingo
A S
AS
Research Institute, Hyogo University, Japan. sheala@mcn.ne.jp
Yonezawa
M
M
Sakurai
K
K
Kito
S
S
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D009838:Oligodeoxyribonucleotides / Q000737:chemistry / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012097:Repressor Proteins / Q000037:antagonists & inhibitors*
D009838:Oligodeoxyribonucleotides; D012097:Repressor Proteins; D009538:Nicotine