title: [Role of radiotherapy in the treatment of cerebral meningiomas].
abstract: Cerebral meningiomas account for 15-20% of all cerebral tumours. Although seldom malignant, they frequently recur in spite of complete surgery, which remains the cornerstone of the treatment. In order to decrease the probability of local recurrence, radiotherapy has often been recommended in atypical or malignant meningioma as well as in benign meningioma which was incompletely resected. However, this treatment never was the subject of prospective studies, randomized or not. The purpose of this review of the literature was to give a progress report on the results of different published series in the field of methodology as well as in the techniques of radiotherapy. Proposals for a therapeutic choice are made according to this analysis. For grade I or grade II-III meningiomas, limits of gross tumor volume (GTV) include the tumour in place or the residual tumour after surgery; clinical target volume (CTV) limits include gross tumour volume before surgery with a GTV-CTV distance of 1 and 2 cm respectively. Delivered doses are 55 Gy into CTV and 55-60 Gy and 70 Gy into GTV for grade I and grade II-III meningiomas respectively.
authors.affiliation: Centre de protonthérapie d'Orsay, BP 65, 91402 Orsay, France. noel@ipno.in2p3.fr
authors.forename: G
authors.initials: G
authors.lastname: Noël
authors.forename: A
authors.initials: A
authors.lastname: Renard
authors.forename: C
authors.initials: C
authors.lastname: Valéry
authors.forename: K
authors.initials: K
authors.lastname: Mokhtari
authors.forename: J J
authors.initials: JJ
authors.lastname: Mazeron
mesh_terms: D000465:Algorithms; D017024:Chemotherapy, Adjuvant; D003663:Decision Trees; D006801:Humans; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D008579:Meningioma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery; D011379:Prognosis; D011859:Radiography; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012307:Risk Factors; D016896:Treatment Outcome