title: Indole alkaloids from the seeds of Centaurea cyanus (Asteraceae).
abstract: Preparative RP-HPLC analysis of a methanol extract of the seeds of Centaurea cyanus afforded four indole alkaloids: moschamine, cis-moschamine, centcyamine and cis-centcyamine, the latter two being new natural products. Structures of these compounds were elucidated by comprehensive spectroscopic analyses. General toxicity of the isolates was determined by Brine Shrimp Lethality bioassay.
authors.affiliation: School of Pharmacy, The Robert Gordon University, Schoolhill, AB10 1FR, Scotland, Aberdeen, UK. s.sarker@rgu.ac.uk
authors.forename: S D
authors.initials: SD
authors.lastname: Sarker
authors.forename: A
authors.initials: A
authors.lastname: Laird
authors.forename: L
authors.initials: L
authors.lastname: Nahar
authors.forename: Y
authors.initials: Y
authors.lastname: Kumarasamy
authors.forename: M
authors.initials: M
authors.lastname: Jaspars
mesh_terms: D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D000818:Animals; D001156:Artemia / Q000187:drug effects; D019659:Asteraceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D000470:Alkaloids; D007211:Indoles