Behavior of phalangeal bone ultrasound in normal women with relation to gonadal status and body mass index.
The behavior of phalangeal bone ultrasound was studied, measured by amplitude-dependent speed of sound (Ad-SOS) in meters per second, in 324 normal women (mean age 48.9 +/- 13.7 years) classified by gonadal status (premenopausal, perimenopausal and postmenopausal) and body mass index (BMI, thin, normal, overweight and obese). Ad-SOS differed significantly with gonadal status and BMI (p<0.0001 for all). In the overall group of women, Ad-SOS correlated negatively with age (r=-0.84, p<0.0001), weight (r=-0.16, p<0.005), BMI (r=-0.27, p<0.0001), and tartrate-resistant acid phosphatase concentration (TRAP) (r=-0.35, p<0.0001). The negative correlation remained significant in the groups separated by gonadal status, but to a lesser extent. After adjusting for confounding variables such as age and weight, Ad-SOS was dependent on age (but not on weight or BMI) in the overall group of women and in the gonadal status groups. In conclusion, Ad-SOS values differed significantly with gonadal status and BMI, and correlated negatively with TRAP. The plot of Ad-SOS against age differed significantly with gonadal status as well as BMI.
Rico
H
H
Department of Medicine of the University of Alcala, Madrid, Spain. horacio.rico@uah.es
Aguado
F
F
Arribas
I
I
Hernández
E R
ER
Villa
L F
LF
Seco
C
C
Gervas
J J
JJ
D000135:Acid Phosphatase / Q000032:analysis; D000328:Adult; D015415:Biomarkers / Q000032:analysis; D015992:Body Mass Index; D005260:Female; D005529:Foot Bones / Q000000981:diagnostic imaging* / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008593:Menopause / Q000502:physiology*; D008875:Middle Aged; D017697:Premenopause / Q000502:physiology*; D000071681:Tartrate-Resistant Acid Phosphatase; D014463:Ultrasonography
D015415:Biomarkers; D007527:Isoenzymes; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase