Mechanism-based inhibition of an essential bacterial adenine DNA methyltransferase: rationally designed antibiotics.
Wahnon
D C
DC
The Pennsylvania State University Department of Chemistry, 414 Wartik Laboratory University Park, Pennsylvania 16802, USA.
Shier
V K
VK
Benkovic
S J
SJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific) / Q000037:antagonists & inhibitors*
D000900:Anti-Bacterial Agents; D004791:Enzyme Inhibitors; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)