Acquired glomerulocystic kidney disease following hemolytic uremic syndrome.
Glomerulocystic kidney disease (GCKD) is a rare congenital condition that is usually reported in infants and young children. Only five cases of acquired GCKD after an acquired renal disease have been reported. Among these, two patients have developed cystic glomerular lesions following hemolytic uremic syndrome (HUS). We report a third case in a 2-year-old patient with this association. Common features between these three cases include atypical HUS, development of GCKD after prolonged peritoneal dialysis treatment, severe hypertension, and normal-sized kidneys without development of macroscopic cysts. Pathology findings in our patient include heavy expression of epidermal growth factor receptor in proximal tubules and evidence of obstruction of the glomerular outflow. We speculate that cystic dilatation of the Bowman's capsule may be secondary to ischemic lesions leading to proximal tubular obstruction.
Emma
F
F
Division of Nephrology, Children's Hospital and Research Institute Bambino Gesu', Rome, Italy. emma@opbg.net
Muda
A O
AO
Rinaldi
S
S
Boldrini
R
R
Bosman
C
C
Rizzoni
G
G
D002675:Child, Preschool; D066246:ErbB Receptors / Q000096:biosynthesis / Q000235:genetics; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000150:complications* / Q000473:pathology; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000209:etiology* / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D010530:Peritoneal Dialysis
D066246:ErbB Receptors