[Pharmacologic analysis of the radiation-protecting effect of indraline].
In comparative studies of the influence of selective alpha 1-adrenoblockager prazosine on radioprotective effect of indraline and mesotone it was found that the mechanism for their radioprotective effect was completely realized via alpha 1-adrenergic action. Calcium blockager nifedipine did not block the indraline effect. It was discussed the issue of classifying of indraline as alpha 1B-adrenomimetic.
Vasin
M V
MV
Institute Military Medicine, Moscow, 125083 Russia.
Ushakov
I B
IB
Semenova
L A
LA
Kovtun
V Iu
VIu
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology*; D000818:Animals; D005260:Female; D051379:Mice; D010636:Phenols / Q000494:pharmacology*; D011837:Radiation-Protective Agents / Q000494:pharmacology*
D058668:Adrenergic alpha-1 Receptor Antagonists; D000317:Adrenergic alpha-Antagonists; D010636:Phenols; D011837:Radiation-Protective Agents; C086896:indralin