title: Molecular-orbital study of hydroxylation of collagenous proline and lysine.
abstract: EHT and CNDO/2 types of calculations permit the interpretation of the course of hydroxylation of collagenous proline and lysine. Calculations were performed for the models of proline (I), zwitterion of proline (II), proline-containing peptide (III), and lysine (IV). The theoretical results are consistent with an electrophilic mechanism.
authors.affiliation: Institute of Physical Chemistry, Czechoslovak Academy of Sciences, Prague, Czechoslovakia.
authors.forename: R
authors.initials: R
authors.lastname: Zahradník
authors.forename: P
authors.initials: P
authors.lastname: Hobza
authors.forename: J
authors.initials: J
authors.lastname: Hurych
mesh_terms: D003094:Collagen / Q000737:chemistry*; D004563:Electrochemistry / Q000379:methods; D006900:Hydroxylation; D006901:Hydroxylysine / Q000737:chemistry*; D006909:Hydroxyproline / Q000737:chemistry*; D008239:Lysine / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D011392:Proline / Q000737:chemistry*; D011487:Protein Conformation
chemical_list: D006901:Hydroxylysine; D003094:Collagen; D011392:Proline; D008239:Lysine; D006909:Hydroxyproline