title: Biological applications of hammerhead ribozymes as anti-viral molecules.
abstract: Ribozymes are catalytic RNAs that can cleave substrate RNAs in a sequence specific manner. Here we survey, in brief, the structure of hammerhead and hairpin ribozymes and discuss their applications as molecular antiviral molecules for HIV-1.
authors.affiliation: Department of Chemistry, San Jose State University, San Jose, CA 95192, USA.
authors.forename: B
authors.initials: B
authors.lastname: Lustig
authors.forename: K T
authors.initials: KT
authors.lastname: Jeang
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D012313:RNA / Q000378:metabolism; D016337:RNA, Catalytic / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000998:Antiviral Agents; D016337:RNA, Catalytic; C418481:hairpin ribozyme; C427204:hammerhead ribozyme; D012313:RNA