Sequelae and complications related to dental extractions in patients with hematologic malignancies and the impact on medical outcome.
OBJECTIVE
The purpose of this retrospective study was to evaluate sequelae and complications after dental extractions and to analyze their impact on medical treatment in patients with myelodysplastic syndrome, acute and chronic leukemia, and multiple myeloma during a 3-year period.


METHODS
The study population included 388 patients with hematologic malignancies. All medical and dental charts were reviewed in a retrospective fashion to identify patients who received dental extractions. Preexisting dental disease and intervention (extraction) were evaluated, and parameters such as days of hospitalization and survival rate were compared with those of the remainder population who did not receive dental extractions.


RESULTS
Of the 388 patients, 69 underwent dental extractions and 9 had sequelae and complications after the intervention. The resulting complication rate of 13% was reported. Although some patients did experience delay of chemotherapy or bone marrow transplant (BMT), or both, no significant difference was found in the number of days in the hospital for BMT and the survival rate for the patients with sequelae and complications (n = 9) and for the remainder population (n = 319) ( >.05).


CONCLUSIONS
Dental extraction intervention provided in the prechemotherapy and pre-BMT time frame did not have a negative bearing on medical outcome.
Raut
A
A
Dental Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Huryn
J M
JM
Hwang
F R
FR
Zlotolow
I M
IM
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D019337:Hematologic Neoplasms / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D006760:Hospitalization; D006801:Humans; D007902:Length of Stay; D007938:Leukemia / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D009190:Myelodysplastic Syndromes / Q000150:complications / Q000503:physiopathology / Q000628:therapy; D011183:Postoperative Complications; D012189:Retrospective Studies; D013223:Statistics as Topic; D015996:Survival Rate; D013997:Time Factors; D014081:Tooth Extraction / Q000009:adverse effects*; D016896:Treatment Outcome
D000970:Antineoplastic Agents