Antimalarial halorosellinic acid from the marine fungus Halorosellinia oceanica.
Three known compounds, 2-hexylidene-3-methylsuccinic acid (1), cytochalasin Q (2), and 5-carboxymellein (3), together with two new derivatives, 2-hexylidene-3-methylsuccinic acid 4-methyl ester (4) and an ophiobolane sesterterpene named halorosellinic acid (5), were isolated from culture broth of the marine fungus Halorosellinia oceanica BCC 5149. Compounds 1-3 exhibited moderate cytotoxicity against KB and BC-1 cell lines with IC(50) values of 1-13 microg/mL, while compounds 2, 3, 5, and 6 showed antimalarial activity with respective IC(50) values of 17, 4, 13, and 19 microg/mL. Halorosellinic acid (5) possessed only weak antimycobacterial activity with the minimum inhibitory concentration of 200 microg/mL.
Chinworrungsee
M
M
Department of Chemistry, Faculty of Science, Mahidol University, Rajdhevee, 10400, Bangkok, Thailand.
Kittakoop
P
P
Isaka
M
M
Rungrod
A
A
Tanticharoen
M
M
Thebtaranonth
Y
Y
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis / Q000494:pharmacology*; D003572:Cytochalasins / Q000138:chemical synthesis / Q000494:pharmacology; D005658:Fungi / Q000737:chemistry; D006801:Humans; D020128:Inhibitory Concentration 50; D049934:Isocoumarins; D007624:KB Cells; D008826:Microbial Sensitivity Tests; D009159:Mycobacteriaceae / Q000187:drug effects*; D009793:Ochratoxins / Q000138:chemical synthesis / Q000494:pharmacology; D010963:Plasmodium falciparum / Q000187:drug effects*; D054830:Sesterterpenes; D013386:Succinates / Q000138:chemical synthesis / Q000494:pharmacology; D013729:Terpenes / Q000138:chemical synthesis / Q000494:pharmacology*
D000962:Antimalarials; D003572:Cytochalasins; D049934:Isocoumarins; D009793:Ochratoxins; D054830:Sesterterpenes; D013386:Succinates; D013729:Terpenes; C435778:halorosellinic acid; C002884:ophiobolins; C039138:methylsuccinic acid; C120538:ochracin