title: Atypical membranoproliferative glomerulonephritis in a cat.
abstract: Membranoproliferative glomerulonephritis was observed in a 2-year-old male Japanese domestic cat with clinical renal failure. In the glomeruli, moderate mesangial hypercellularity with an increased mesangial matrix and thickening of the capillary walls were prominent. In addition, frequent duplication of the capillary walls, splitting, and spike formation were observed in the glomerular basement membrane. Granular cat IgG and complement component deposition were detected globally along the glomerular capillary walls and in the mesangium. Transmission electron microscopy revealed dense deposits in the subendothelial and subepithelial regions and the mesangium. Mesangial interposition was also observed. These glomerular lesions are also found in humans with membranoproliferative glomerulonephritis type III, which has not been reported in animals.
authors.affiliation: Research Institute of Biosciences, Azabu University, Sagamihara, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Inoue
authors.forename: J
authors.initials: J
authors.lastname: Kami-ie
authors.forename: S
authors.initials: S
authors.lastname: Ohtake
authors.forename: S
authors.initials: S
authors.lastname: Wakui
authors.forename: S
authors.initials: S
authors.lastname: Machida
authors.forename: K
authors.initials: K
authors.lastname: Shirota
mesh_terms: D000818:Animals; D001706:Biopsy / Q000662:veterinary; D002371:Cat Diseases / Q000473:pathology*; D002415:Cats; D015432:Glomerulonephritis, Membranoproliferative / Q000473:pathology / Q000662:veterinary*; D006651:Histocytochemistry / Q000662:veterinary; D007678:Kidney Glomerulus / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary