Levofloxacin and warfarin interaction.
Numerous case reports have documented an enhanced hypoprothrombinemic effect caused by an interaction between fluoroquinolones (most notably, ciprofloxacin) and warfarin sodium. Conflicting data exist regarding the clinical significance of this interaction. Two patients who had elevated international normalized ratios after receiving concurrent levofloxacin and warfarin sodium are described.
Ravnan
S L
SL
University of the Pacific School of Pharmacy and Health Science, Sockton, California, 95221, USA. Sravnan@aol.com
Locke
C
C
D000368:Aged; D000890:Anti-Infective Agents / Q000493:pharmacokinetics*; D000925:Anticoagulants / Q000493:pharmacokinetics*; D001777:Blood Coagulation / Q000187:drug effects / Q000502:physiology; D004347:Drug Interactions / Q000502:physiology; D006801:Humans; D019934:International Normalized Ratio; D064704:Levofloxacin; D008297:Male; D015242:Ofloxacin / Q000493:pharmacokinetics*; D014859:Warfarin / Q000493:pharmacokinetics*
D000890:Anti-Infective Agents; D000925:Anticoagulants; D014859:Warfarin; D064704:Levofloxacin; D015242:Ofloxacin