title: Nitrobenzene compounds inhibit expression of VCAM-1.
abstract: A series of nitrobenzene compounds has been discovered as potent inhibitors of VCAM-1 expression and, therefore, potential drug candidates for autoimmune and allergic inflammatory diseases. Structure-activity relationship (SAR) studies showed that a nitro group and two other electron-withdrawing groups are essential for these compounds to be potent inhibitors of VCAM-1 expression.
authors.affiliation: AtheroGenics, Inc., 8995 Westdise Parkway, 30004, Alpharetta, GA, USA. cmeng@atherogenics.com
authors.forename: C Q
authors.initials: CQ
authors.lastname: Meng
authors.forename: X S
authors.initials: XS
authors.lastname: Zheng
authors.forename: L A
authors.initials: LA
authors.lastname: Holt
authors.forename: L K
authors.initials: LK
authors.lastname: Hoong
authors.forename: P K
authors.initials: PK
authors.lastname: Somers
authors.forename: R R
authors.initials: RR
authors.lastname: Hill
authors.forename: U
authors.initials: U
authors.lastname: Saxena
mesh_terms: D001327:Autoimmune Diseases / Q000188:drug therapy; D002478:Cells, Cultured / Q000166:cytology; D004579:Electron Transport; D004727:Endothelium / Q000166:cytology; D006801:Humans; D006967:Hypersensitivity / Q000188:drug therapy; D007249:Inflammation / Q000188:drug therapy; D020128:Inhibitory Concentration 50; D039041:Integrin alpha4beta1; D016023:Integrins / Q000378:metabolism; D018799:Intercellular Adhesion Molecule-1 / Q000187:drug effects*; D009578:Nitrobenzenes / Q000138:chemical synthesis* / Q000494:pharmacology*; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism; D013329:Structure-Activity Relationship; D019010:Vascular Cell Adhesion Molecule-1 / Q000096:biosynthesis / Q000187:drug effects* / Q000235:genetics
chemical_list: D039041:Integrin alpha4beta1; D016023:Integrins; D009578:Nitrobenzenes; D016201:Receptors, Lymphocyte Homing; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1