The impact of norfloxacin, ciprofloxacin and ofloxacin on human gut colonization by Candida albicans.
We studied gastrointestinal (GI) colonization by Candida albicans in patients receiving oral norfloxacin, ciprofloxacin or ofloxacin as monotherapy for urinary tract infections. Quantitative stool cultures for C. albicans were performed before, at the end and 1 week after the end of treatment. All 3 quinolones increased GI colonization by C. albicans. Ciprofloxacin caused the highest increase, which was not statistically significant.
Mavromanolakis
E
E
Department of Urology, University Hospital of Iráklion, Crete, Greece.
Maraki
S
S
Cranidis
A
A
Tselentis
Y
Y
Kontoyiannis
D P
DP
Samonis
G
G
D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002176:Candida albicans / Q000187:drug effects*; D002939:Ciprofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D004064:Digestive System / Q000187:drug effects / Q000382:microbiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009643:Norfloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D015242:Ofloxacin / Q000009:adverse effects* / Q000627:therapeutic use; D014552:Urinary Tract Infections / Q000188:drug therapy
D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D015242:Ofloxacin; D009643:Norfloxacin