Pleuropulmonary disease due to pergolide use for restless legs syndrome.
Pergolide is an ergot-derived dopamine agonist used in Parkinson's disease and, increasingly, in restless legs syndrome. We report a patient with a 2.5-year history of weight loss, pleuropulmonary fibrosis, and exudative pleural effusion that developed insidiously while taking this medication. The extensive and invasive workup that preceded the diagnosis highlights the difficulty in attributing such a process to a drug reaction. This is the second report of such a reaction to pergolide, which is one of the increasing number of ergot-derived compounds in common clinical use.
Danoff
S K
SK
Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Grasso
M E
ME
Terry
P B
PB
Flynn
J A
JA
D000368:Aged; D018491:Dopamine Agonists / Q000009:adverse effects* / Q000627:therapeutic use; D005355:Fibrosis; D006801:Humans; D008297:Male; D010479:Pergolide / Q000009:adverse effects* / Q000627:therapeutic use; D010995:Pleural Diseases / Q000139:chemically induced* / Q000175:diagnosis; D010996:Pleural Effusion / Q000139:chemically induced; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000175:diagnosis; D012148:Restless Legs Syndrome / Q000188:drug therapy*
D018491:Dopamine Agonists; D010479:Pergolide