Cloning and heterologous expression of the macrotetrolide biosynthetic gene cluster revealed a novel polyketide synthase that lacks an acyl carrier protein.
Kwon
H J
HJ
Department of Chemistry, University of California One Shields Avenue, Davis, California 95616, USA.
Smith
W C
WC
Xiang
L
L
Shen
B
B
D000213:Acyl Carrier Protein / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D000429:Alcohol Oxidoreductases / Q000737:chemistry / Q000235:genetics / Q000378:metabolism; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001426:Bacterial Proteins; D001483:Base Sequence; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000235:genetics; D015870:Gene Expression; D018942:Macrolides; D008969:Molecular Sequence Data; D009097:Multienzyme Complexes / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D005810:Multigene Family; D013305:Streptomyces griseus / Q000201:enzymology / Q000235:genetics
D000213:Acyl Carrier Protein; D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D018942:Macrolides; D009097:Multienzyme Complexes; D000429:Alcohol Oxidoreductases; C087192:polyketide synthase ketoreductase