Pre-emptive metoclopramide and ondansetron for nausea and vomiting associated with iloprost infusions.
OBJECTIVE
To assess the effectiveness of ondansetron in relieving symptoms of nausea and vomiting which were refractory to metoclopramide and cyclizine, in a patient receiving iloprost infusions.


METHODS
Case observation in a series of 7 infusions.


RESULTS
Ondansetron reduced WHO symptom scores of vomiting from Grade 2 to Grade 0. Symptoms of nausea were abolished on some occasions.


CONCLUSIONS
Ondansetron was found to be effective at abolishing symptoms of vomiting and partially effective against symptoms of nausea. It may prove to be a useful treatment modality to allow the patient to tolerate further infusions of iloprost where nausea and vomiting has failed to respond to other agents.
Roome
C
C
Royal Devon & Exeter Hospital (Wonford), Barrack Road, Exeter, England EX2 5DW, UK.
Thompson
J
J
D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use*; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage / Q000009:adverse effects*; D007262:Infusions, Intravenous; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced* / Q000188:drug therapy*; D017294:Ondansetron / Q000627:therapeutic use*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000009:adverse effects*; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy
D000932:Antiemetics; D010975:Platelet Aggregation Inhibitors; D017294:Ondansetron; D016285:Iloprost; D008787:Metoclopramide