title: Esters of chlorambucil with 2-substituted 1,4-dihydroxy-9,10-anthraquinones as multifunctional anticancer agents.
abstract: Novel twelve esters of chlorambucil with 2-(1-hydroxyalkyl)-1,4-dihydroxy-9,10-anthraquinone were synthesized and tested for their antitumor activity in mice bearing S-180 ascitic cells as well as cytotoxic activity against L1210 cells. Eight of them were highly cytotoxic on L1210 cells (ED(50), <6 microg mL(-1)) and derivatives 1 and 12 (T/C, 200 and 205%) appeared more active in vivo than chlorambucil (T/C, 168%).
authors.affiliation: College of Pharmacy, Yanbian University, Yanji, Jilin 133000, People's Republic of China.
authors.forename: G Z
authors.initials: GZ
authors.lastname: Jin
authors.forename: Y J
authors.initials: YJ
authors.lastname: You
authors.forename: Y
authors.initials: Y
authors.lastname: Kim
authors.forename: N H
authors.initials: NH
authors.lastname: Nam
authors.forename: B Z
authors.initials: BZ
authors.lastname: Ahn
mesh_terms: D000818:Animals; D000880:Anthraquinones / Q000737:chemistry* / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D002699:Chlorambucil / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000401:mortality; D013329:Structure-Activity Relationship
chemical_list: D000880:Anthraquinones; D000970:Antineoplastic Agents; D002699:Chlorambucil