title: Acid-related diseases following retrosternal stomach interposition.
abstract: OBJECTIVE
  Esophagectomy and reconstruction with retrosternal stomach interposition implies bilateral truncal vagotomy, which supposedly causes gastric functional impairment.
  
  
  METHODS
  Esophagectomy and reconstruction with retrosternal stomach interposition was performed on 15 men (mean age: 58.4 years) and 3 women (mean age: 43.6 years). The stomach was pedicled on the right gastric and right gastroepiploic artery without performing pyloroplasty. The cervical side-to-end anastomosis was sutured manually. The functional results were assessed 2-4 years postoperatively, by determining 24-hour qualitative intragastric pH-measurement, fluoroscopical gastric emptying studies, fasting gastrin levels, and endoscopy with biopsy studies.
  
  
  RESULTS
  Endoscopy and biopsy confirmed esophagitis in 12 patients, gastritis in 15 and a gastric ulcer in 1 case. Fluoroscopic examination documented a normal passage of contrast medium in 17, slight impairment in 1 case treated by balloon dilatation of the pylorus. Qualitative intragastric pH-measurement revealed a total pH < 3 in 22.5-98.05% of measuring events (mean: 74.31%) within 24 hours, in 18 cases. Only 4 patients had pH < 3 in less than 50%. Fasting gastrin levels (normal range: 25-110 mU/L) varied from 48.78 mU/L-168.20 (mean: 85.23 mU/L). Only 3 patients had levels > 110 mU/L (maximum: 168.20 mU/L).
  
  
  CONCLUSIONS
  Acid-related diseases may also occur after truncal vagotomy and retrosternal stomach interposition. Routine follow-up endoscopy and biopsy studies should be done to prevent inflammatory complications and maintain the patient's quality of life.
authors.affiliation: Department of Surgery, Division of Thoracic and Hyperbaric Surgery, University Medical School, Auenbruggerplatz 29, A-8036 Graz, Austria. alfred.maier@klinikum-graz.at
authors.forename: A
authors.initials: A
authors.lastname: Maier
authors.forename: F
authors.initials: F
authors.lastname: Tomaselli
authors.forename: O
authors.initials: O
authors.lastname: Sankin
authors.forename: U
authors.initials: U
authors.lastname: Anegg
authors.forename: B
authors.initials: B
authors.lastname: Fell
authors.forename: H
authors.initials: H
authors.lastname: Renner
authors.forename: H
authors.initials: H
authors.lastname: Pinter
authors.forename: G B
authors.initials: GB
authors.lastname: Friehs
authors.forename: F M
authors.initials: FM
authors.lastname: Smolle-Jüttner
mesh_terms: D000328:Adult; D000368:Aged; D000714:Anastomosis, Surgical; D016629:Esophagectomy / Q000379:methods*; D005260:Female; D005745:Gastric Acidity Determination; D005746:Gastric Emptying / Q000502:physiology; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000175:diagnosis; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D013270:Stomach / Q000601:surgery*; D013276:Stomach Ulcer / Q000175:diagnosis; D015167:Vagotomy, Truncal
chemical_list: D005755:Gastrins