Myopathy with tubulin-reactive crystalline inclusions.
A 61-year-old man with muscle aches and persistently elevated serum creatine kinase had aggregates of randomly oriented, rhomboidal or rectangular protein crystalline inclusions in the sarcoplasm of type II fibers. Immunochemical studies showed strong reactivity of the inclusions to tubulin antibodies, suggesting that these unique crystalline inclusions may be a consequence of altered synthesis, processing, or degradation of tubulin.
Vu
T H
TH
H. Houston Merritt Clinical Research Center for Muscular Dystrophy and Related Disorders and Department of Neurology, Columbia University, New York, NY 10032, USA.
Hays
A P
AP
Tanji
K
K
Younger
D
D
Gundersen
G G
GG
Eastwood
A
A
Braun
C W
CW
DiMauro
S
S
Bonilla
E
E
D003460:Crystallization; D006801:Humans; D002479:Inclusion Bodies / Q000378:metabolism* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D018485:Muscle Fibers, Skeletal / Q000378:metabolism / Q000473:pathology; D009135:Muscular Diseases / Q000378:metabolism* / Q000473:pathology*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism / Q000473:pathology; D014404:Tubulin / Q000737:chemistry / Q000378:metabolism*
D014404:Tubulin