Patch testing discordance alert: false-negative findings with rubber additives and fragrances.
From July 1996 through June 1998, the North American Contact Dermatitis Group evaluated 318 patients for suspected contact dermatitis by patch testing simultaneously with Finn Chambers and the T.R.U.E. Test allergen system. Discrepancies between the two systems were found in some of the results, particularly with fragrance and rubber allergens. These results suggest that positive reactions to fragrance, thiuram, and carba mix allergens may be missed if the T.R.U.E. Test is used alone.
Sherertz
E F
EF
Department of Dermatology, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
Fransway
A F
AF
Belsito
D V
DV
DeLeo
V A
VA
Fowler
J F
JF
Maibach
H I
HI
Marks
J G
JG
Mathias
C G
CG
Pratt
M D
MD
Rietschel
R L
RL
Taylor
J S
JS
D000485:Allergens; D001453:Balsams / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000175:diagnosis*; D004050:Ditiocarb / Q000009:adverse effects; D005188:False Negative Reactions; D006146:Guanidines / Q000009:adverse effects / Q000276:immunology; D006801:Humans; D020315:Latex Hypersensitivity / Q000175:diagnosis*; D010328:Patch Tests / Q000295:instrumentation; D010476:Perfume / Q000009:adverse effects; D013859:Thiocarbamates / Q000009:adverse effects / Q000276:immunology; D013893:Thiram / Q000009:adverse effects / Q000276:immunology
D000485:Allergens; D001453:Balsams; D006146:Guanidines; D010476:Perfume; D013859:Thiocarbamates; D013893:Thiram; C057051:carbamix; C025080:Peruvian balsam; D004050:Ditiocarb