title: HELLP syndrome in the 18th week of gestation in association with elevated angiotensin AT(1)-receptor autoantibodies.
abstract: We present a 24-year-old woman with a twin pregnancy who was with a typical HELLP syndrome at the 18th week of pregnancy. One fetus was dead, while the other was severely growth retarded. Our patient had agonistic autoantibodies directed at the angiotensin AT(1)-receptor. Termination of the pregnancy proved necessary. This report is the first to our knowledge associating HELLP syndrome with angiotensin AT(1)-receptor antibodies. Since the antibodies may have a pathogenic significance, their removal could permit the prolongation of pregnancy in preeclamptic and HELLP syndrome patients.
authors.affiliation: Department of Gynecology and Obstetrics, University of Erlangen/Nuremberg, Universitaetsstrasse 21, D-91054, Erlangen, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Fischer
authors.forename: G
authors.initials: G
authors.lastname: Wallukat
authors.forename: M P
authors.initials: MP
authors.lastname: Schneider
authors.forename: D
authors.initials: D
authors.lastname: Schlembach
authors.forename: W
authors.initials: W
authors.lastname: Munz
authors.forename: V
authors.initials: V
authors.lastname: Homuth
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D005313:Fetal Death / Q000276:immunology; D005317:Fetal Growth Retardation / Q000276:immunology; D005865:Gestational Age; D017359:HELLP Syndrome / Q000276:immunology*; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage; D011247:Pregnancy; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin / Q000276:immunology*; D014427:Twins
chemical_list: D001323:Autoantibodies; D044140:Receptor, Angiotensin, Type 1; D044139:Receptor, Angiotensin, Type 2; D011945:Receptors, Angiotensin; D008775:Methylprednisolone