title: Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei.
abstract: 13 quinic acid derivatives along with caffeic acid, methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract of the flower buds of Lonicera bournei Hemsl., among which 8 compounds were firstly obtained from this genus. The effects of different solvent soluble fractions of the ethanol extract and the pure compounds on heptocyte death induced by D-galactosamine (D-GalN)/tumor necrosis factor alpha (TNF-alpha) were studied, and the structure-activity relationships were also discussed.
authors.affiliation: Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
authors.forename: T
authors.initials: T
authors.lastname: Xiang
authors.forename: Q B
authors.initials: QB
authors.lastname: Xiong
authors.forename: A I
authors.initials: AI
authors.lastname: Ketut
authors.forename: Y
authors.initials: Y
authors.lastname: Tezuka
authors.forename: T
authors.initials: T
authors.lastname: Nagaoka
authors.forename: L J
authors.initials: LJ
authors.lastname: Wu
authors.forename: S
authors.initials: S
authors.lastname: Kadota
mesh_terms: D000818:Animals; D017209:Apoptosis; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects*; D004365:Drugs, Chinese Herbal; D004987:Ethers / Q000302:isolation & purification* / Q000494:pharmacology; D005688:Galactosamine / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects*; D066298:In Vitro Techniques; D007294:Inositol / Q000494:pharmacology; D008099:Liver / Q000166:cytology* / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D014468:Umbelliferones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D002109:Caffeic Acids; D004365:Drugs, Chinese Herbal; D004987:Ethers; D006027:Glycosides; D014409:Tumor Necrosis Factor-alpha; D014468:Umbelliferones; C431423:bis(5-formylfurfuryl)ether; D011801:Quinic Acid; D007294:Inositol; D005688:Galactosamine; C007628:esculetin