Report of three cases of circulating heparin-like anticoagulants.
Clinically significant endogenous circulating heparin-like anticoagulant activity has been associated with hematological malignancies, liver damage, and other pathological conditions. The source of high plasma concentrations of endogenous heparin-like anticoagulants is poorly understood. We report three cases of circulating heparin-like anticoagulants in three patients with hematological malignancies: CLL, multiple myeloma, and T-prolymphocytic leukemia. The severity of bleeding in our patients ranged from severe epistaxis and deep-site hematoma to bleeding of biopsy site and occasional ecchymosis.
Llamas
P
P
Hematology and Hemotherapy Department, Fundación Jiménez Díaz, Madrid, Spain. pllamas@fjd.es
Outeiriño
J
J
Espinoza
J
J
Santos
A B
AB
Román
A
A
Tomás
J F
JF
D000368:Aged; D000925:Anticoagulants / Q000097:blood*; D019337:Hematologic Neoplasms / Q000097:blood* / Q000150:complications; D006470:Hemorrhage / Q000209:etiology; D006493:Heparin / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013918:Thrombin Time
D000925:Anticoagulants; D006493:Heparin