title: Antiplasmodial and antioxidant isofuranonaphthoquinones from the roots of Bulbine capitata.
abstract: The roots of B. capitata yielded the new compounds 5,8-dihydroxy-1-tigloylmethylnaphtho[2,3-c]furan-4,9-dione, 1-acetoxymethyl-8-hydroxynaphtho[2,3-c]furan-4,9-dione, and 1-acetoxymethyl-5,8-dihydroxynaphtho[2,3-c]furan-4,9-dione, in addition to the known compounds chrysophanol, 10,10'-chrysophanol bianthrone, 8-hydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-methylnaphtho[2,3-c]furan-4,9-dione, 5,8-dihydroxy-1-hydroxymethylnaphtho[2,3-c]furan-4,9-dione, and 8-hydroxy-5-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione, or 5-hydroxy-8-methoxy-1-methylnaphtho[2,3-c]furan-4,9-dione. The new as well as the known isofuranonaphthoquinones showed antioxidant and weak antiplasmodial activities.
authors.affiliation: Department of Chemistry, University of Botswana, Gaborone, Botswana.
authors.forename: M
authors.initials: M
authors.lastname: Bezabih
authors.forename: B M
authors.initials: BM
authors.lastname: Abegaz
authors.forename: K
authors.initials: K
authors.lastname: Dufall
authors.forename: K
authors.initials: K
authors.lastname: Croft
authors.forename: T
authors.initials: T
authors.lastname: Skinner-Adams
authors.forename: T M
authors.initials: TM
authors.lastname: Davis
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D019271:Hypoxanthine / Q000494:pharmacology; D008054:Lipid Peroxides / Q000032:analysis; D008077:Lipoproteins, LDL / Q000097:blood; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects
chemical_list: D000962:Antimalarials; D000975:Antioxidants; D005663:Furans; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; D009285:Naphthoquinones; D019271:Hypoxanthine