Effect of pravastatin in mildly hypercholesterolemic young men on serum matrix metalloproteinases.
Pravastatin decreases serum MMP-9 concentration in clinically healthy men. This may reflect reduction of nonsymptomatic chronic arterial inflammation.
Kalela
A
A
Department of Medical Biochemistry, University of Tampere Medical School, Tampere, Finland.
Laaksonen
R
R
Lehtimäki
T
T
Koivu
T A
TA
Höyhtyä
M
M
Janatuinen
T
T
Pöllänen
P
P
Vesalainen
R
R
Saikku
P
P
Knuuti
J
J
Nikkari
S T
ST
D000328:Adult; D000924:Anticholesteremic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D005838:Genotype; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors / Q000494:pharmacology / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000201:enzymology; D008297:Male; D020780:Matrix Metalloproteinase 9 / Q000097:blood* / Q000187:drug effects / Q000235:genetics; D011110:Polymorphism, Genetic; D017035:Pravastatin / Q000494:pharmacology / Q000627:therapeutic use*
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D020780:Matrix Metalloproteinase 9; D017035:Pravastatin