Nuclear pore complexes: dynamics in unexpected places.
In vivo studies on the dynamics of the nuclear pore complex (NPC) in yeast suggested that NPCs are highly mobile in the nuclear envelope. However, new evidence indicates that in mammalian cells NPCs are stably attached to a flexible lamina framework, but a peripheral component can exchange rapidly with an intranuclear pool.
Lyman
S K
SK
Departments of Cell and Molecular Biology, The Scripps Research Institute, 10550 N. Torrey Pines Rd., La Jolla, CA 92037, USA.
Gerace
L
L
D021581:Active Transport, Cell Nucleus; D000818:Animals; D001485:Basement Membrane / Q000737:chemistry; D002467:Cell Nucleus / Q000378:metabolism*; D008954:Models, Biological; D009685:Nuclear Envelope / Q000378:metabolism*; D022022:Nuclear Pore / Q000378:metabolism*; D028861:Nuclear Pore Complex Proteins; D009687:Nuclear Proteins / Q000737:chemistry
D028861:Nuclear Pore Complex Proteins; D009687:Nuclear Proteins