[Induction by ethanol of 'phenomenon of switching estrogen effect' and its correction].
Drinking of 5% ethanol in combination with estradiol induced genotoxic (G) changes in the rat uterine tissue. The changes could be prevented by N-acetylcysteine or melatonin. The data obtained suggest that ascorbic acid and alpha-tocopherol may be recommended in combination with N-acetylcysteine for repair of estrogen effect switching phenomenon.
Bershteĭn
L M
LM
Petrov Research Institute of Oncology, 189646, St. Petersburg, Pesochny-2, Russia.
Tsyrlina
E V
EV
Poroshina
T E
TE
Bychkova
N V
NV
Kalinina
N M
NM
Gamaiunova
V B
VB
Kriuchkova
O G
OG
Kovalenko
I G
IG
Vasil'ev
D A
DA
D000111:Acetylcysteine / Q000494:pharmacology; D000428:Alcohol Drinking / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology; D002336:Carnosine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D020552:Comet Assay; D004249:DNA Damage; D004958:Estradiol / Q000633:toxicity*; D005260:Female; D008550:Melatonin / Q000494:pharmacology; D010052:Ovariectomy; D051381:Rats; D013550:Swimming; D014599:Uterus / Q000473:pathology; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D014810:Vitamin E; D004958:Estradiol; D002336:Carnosine; D008550:Melatonin; D001205:Ascorbic Acid; D000111:Acetylcysteine