[African swine fever virus: achievements over the last decade of the 20th century].
Complete nucleotide sequence of African swine fever (ASF) virus genome was determined in 1993-1999. Deletion mutants with low virulence for pigs were obtained. Genes of structural (p72, p54, p12, cleavage products pp220 and pp60, hemagglutinin) and nonstructural (p32) proteins were mapped. The significance of different proteins in virus adsorption and resistance to challenge was elucidated, their location in infected cell and virion was determined. Lipid composition of the virus was studied. A protocol of virion morphogenesis was suggested, which explains their morphology. Apoptosis, consumption coagulopathy, and development of delayed type hypersensitivity are regarded as the main pathogenetic mechanisms. Antigens acting as targets and inductors of immune cytological reactions and antibodies mediating suppression of virus reproduction were determined.
Kolontsov
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Orekhovo-Zuevo Pedagogical Institute, Orekhovo-Zuevo, Moscow Region.
D000357:African Swine Fever / Q000276:immunology / Q000473:pathology; D000358:African Swine Fever Virus / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D000818:Animals; D016679:Genome, Viral; D013552:Swine; D014764:Viral Proteins / Q000502:physiology; D014771:Virion / Q000502:physiology; D014774:Virulence
D014764:Viral Proteins