Effect of interleukin 10 on the release of the CXC chemokines growth related oncogene GRO-alpha and epithelial cell-derived neutrophil activating peptide (ENA)-78 during human endotoxemia.
Pretreatment with interleukin (IL)-10 inhibited the release of growth-related oncogene GRO-alpha but not of epithelial-cell derived neutrophil activating protein (ENA)-78, after injection of lipopolysaccharide (LPS) into healthy humans. In vitro, IL-10 dose-dependently attenuated LPS-induced release of both GRO-alpha and ENA-78 in whole blood and in cultures of isolated polymorphonuclear and mononuclear cells.
Olszyna
D P
DP
Department of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Room G2-132, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands.
Pajkrt
D
D
van Deventer
S J
SJ
van der Poll
T
T
D000328:Adult; D054360:Chemokine CXCL1; D054365:Chemokine CXCL5; D019743:Chemokines, CXC / Q000032:analysis*; D002630:Chemotactic Factors / Q000032:analysis*; D004311:Double-Blind Method; D019446:Endotoxemia / Q000139:chemically induced / Q000188:drug therapy* / Q000276:immunology; D006133:Growth Substances / Q000032:analysis*; D006801:Humans; D007275:Injections, Intravenous; D036341:Intercellular Signaling Peptides and Proteins; D016753:Interleukin-10 / Q000627:therapeutic use*; D016209:Interleukin-8 / Q000031:analogs & derivatives / Q000032:analysis*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors; D008297:Male; D009504:Neutrophils / Q000276:immunology
C475829:CXCL1 protein, human; C486263:CXCL5 protein, human; D054360:Chemokine CXCL1; D054365:Chemokine CXCL5; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D016209:Interleukin-8; D008070:Lipopolysaccharides; D016753:Interleukin-10