[Plasticity of memory in the brain of white rats after long-term exposure to titanium in drinking water].
The experiment was conducted on male white rats from breeding base of the National Institute of Hygiene: WIS own breeding. During sixteen months the drinking water with TiCl3 in concentrations 5 and 25 mg/l, what is equivalent respectively 0.45 and 2.25 mg per 1 kg of daily weight of rats, was given the animals. After 3 and 15 months of exposure the rats were taught to differentiate and remember sight effects. The investigation of each cluster of rats, living previously in the same cage, was going non-stop by 24 hours for 5 days. The training was carried on in the special adopted cages making possible to record all correct and incorrect attempts in day long cycle. Percentage indicator, the ratio of mistakes to all number of the attempts, was used for assessment the training effectiveness in each group and the result in intoxicated group were compared with control group. During the whole time of exposition the supplying drinking water with TiCl3 in concentrations 5 and 25 mg/l has not caused changes in rats confirming possibility to evoke disorders of brain memory plasticity.
Szuliński
S
S
Zakład Higieny Komunalnej Państwowy Zakład Higieny 00-791 Warszawa.
Strusiński
A
A
D000818:Animals; D008297:Male; D008568:Memory / Q000187:drug effects*; D009473:Neuronal Plasticity / Q000187:drug effects*; D051381:Rats; D014025:Titanium / Q000633:toxicity*; D014873:Water Pollutants / Q000633:toxicity*; D014881:Water Supply
D014873:Water Pollutants; D014025:Titanium