The impact of factor V mutation on the risk for occlusion in patients undergoing peripheral vascular reconstructions.
OBJECTIVE
to determine the impact of Factor V-Leiden on the patency of peripheral vascular reconstructions.


METHODS
prospective, open and consecutive study.


METHODS
a total of 775 patients, who were electively admitted between 1995 and 1997 to the vascular ward unit, were prospectively analysed for frequency of Factor V-Leiden mutation and patency of reconstruction (one month and one year). The patients were grouped into carotid, abdominal aortic aneurysm (AAA), renal artery, aortoiliac, infrainguinal, and venous categories according to procedures and anatomical sites. Post-reconstruction complications and associated risk factors were also analysed.


RESULTS
in infrainguinal patients Factor V-Leiden was seen in 16% of the patients compared with 10% in the controls. (Odds ratio 1.60, CI 0.91-2.81). Hypertension, pulmonary disease and smoking were more frequent in individuals without Factor V-Leiden. Analysing all 775 reconstructions, occlusions were more frequent at one month (14% vs 12%) (p=0.02) in patients with Factor V-Leiden compared with patients without the mutation. Though this trend was also noted few patients having infrainguinal reconstructions, the difference was not significant (37% vs 22% (p=0.15) and 46% vs 27% (p=0.09) after 1 and 12 months, respectively).


CONCLUSIONS
factor V mutation (Factor V-Leiden) was more frequent in patients having occluded vascular reconstructions. Further evaluation is needed.
Sampram
E S
ES
Department of Vascular Diseases Malmö-Lund, Lund University, Malmö, Sweden.
Lindblad
B
B
D020016:Activated Protein C Resistance / Q000235:genetics / Q000401:mortality / Q000601:surgery; D000368:Aged; D001157:Arterial Occlusive Diseases / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D005165:Factor V / Q000235:genetics*; D005260:Female; D005500:Follow-Up Studies; D006580:Genetic Carrier Screening; D006083:Graft Occlusion, Vascular / Q000235:genetics* / Q000401:mortality / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009154:Mutation; D011446:Prospective Studies; D012086:Reoperation; D012307:Risk Factors; D015996:Survival Rate
C095381:factor V Leiden; D005165:Factor V