[Mechanisms of mice resistance to influenza virus A/AICHI/2/68 after preventive injection with polyprenols ].
Preventive effect in influenza can be attained by intramuscular injections of fir (Abies) polyprenols. One of 5 tested polyprenol preparations (No. 1), injected 2 days before aerogenic infection with influenza virus, reliably protected mice from disease. Mice pretreated with polyprenol preparations or Hanks' solution did not differ by accumulation of interferon in the lungs One day after aerogenic infection. Three days after injection of polyprenol preparation No. 1 the weights of the spleen and thymus significantly decreased. One day after injection cell count in the bronchoalveolar tract of mice was almost 2-fold higher than in the control at the expense of lymphocytes and macrophages. After 3 days the relative and absolute counts of macrophages decreased and those of lymphocytes decreased significantly. Three days after injection macrophages were 2-fold more active in absorption of zymosan granules. Preparation No. 1 affected the production of superoxide anion radicals, whose production by all macrophages in the bronchoalveolar tract of mice was significantly higher on day 1 postinjection than on day 3 and higher than on days 1 and 3 after injection of preparation No. 2.
Shishkina
L N
LN
Safatov
A S
AS
Sergeev
A N
AN
P'iankov
O V
OV
Poryvaev
V D
VD
Bulychev
L E
LE
Petrishchenko
V A
VA
P'iankova
O G
OG
Zhukov
V A
VA
Ryzhikov
A B
AB
Boldyrev
A N
AN
Buriak
G A
GA
Raldugin
V A
VA
Kukina
T P
TP
D000818:Animals; D005233:Fatty Alcohols / Q000276:immunology / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects; D008297:Male; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects*; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000517:prevention & control*; D014197:Trees
D005233:Fatty Alcohols