title: ER quality control: towards an understanding at the molecular level.
abstract: The process of 'quality control' in the endoplasmic reticulum (ER) involves a variety of mechanisms that collectively ensure that only correctly folded, assembled and modified proteins are transported along the secretory pathway. In contrast, non-native proteins are retained and eventually targeted for degradation. Recent work provides the first structural insights into the process of glycoprotein folding in the ER involving the lectin chaperones calnexin and calreticulin. Underlying principles governing the choice of chaperone system engaged by different proteins have also been discovered.
authors.affiliation: Institute of Biochemistry, ETH Zürich, Universitätstrasse 16, CH-8092, Zürich, Switzerland. lars.ellgaard@bc.biol.ethz.ch
authors.forename: L
authors.initials: L
authors.lastname: Ellgaard
authors.forename: A
authors.initials: A
authors.lastname: Helenius
mesh_terms: D000818:Animals; D002135:Calcium-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D037281:Calnexin; D037282:Calreticulin; D004721:Endoplasmic Reticulum / Q000502:physiology*; D005964:Glucosyltransferases / Q000378:metabolism; D006023:Glycoproteins / Q000737:chemistry / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism; D007535:Isomerases / Q000378:metabolism; D008954:Models, Biological; D018832:Molecular Chaperones / Q000737:chemistry* / Q000378:metabolism; D017510:Protein Folding; D012261:Ribonucleoproteins / Q000737:chemistry / Q000378:metabolism
chemical_list: D002135:Calcium-Binding Proteins; D037282:Calreticulin; D006023:Glycoproteins; D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D012261:Ribonucleoproteins; D037281:Calnexin; D005964:Glucosyltransferases; C072423:mannosylglycoprotein 1,3-glucosyltransferase; D007535:Isomerases