title: Protein export and drug efflux through bacterial channel-tunnels.
abstract: The bacterial protein TolC assembles into an alpha-helical trans-periplasmic tunnel, which is embedded in the outer membrane by a contiguous beta-barrel channel. TolC and its homologues thus provide large exit ducts for a wide range of substrates, including protein toxins and antibacterial drugs, that are engaged by specific recognition proteins in the cytosolic membrane.
authors.affiliation: Cambridge University Department of Pathology, Tennis Court Road, CB2 1QP, Cambridge, UK.
authors.forename: C
authors.initials: C
authors.lastname: Andersen
authors.forename: C
authors.initials: C
authors.lastname: Hughes
authors.forename: V
authors.initials: V
authors.lastname: Koronakis
mesh_terms: D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry* / Q000235:genetics / Q000502:physiology*; D017124:Conserved Sequence; D004352:Drug Resistance, Microbial; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; D008954:Models, Biological; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D021381:Protein Transport
chemical_list: D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; D026901:Membrane Transport Proteins; C073126:tolC protein, E coli