A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents.
Campiani
G
G
De Angelis
M
M
Armaroli
S
S
Fattorusso
C
C
Catalanotti
B
B
Ramunno
A
A
Nacci
V
V
Novellino
E
E
Grewer
C
C
Ionescu
D
D
Rauen
T
T
Griffiths
R
R
Sinclair
C
C
Fumagalli
E
E
Mennini
T
T
D027322:Amino Acid Transport System X-AG; D000818:Animals; D001224:Aspartic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D001692:Biological Transport; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D015195:Drug Design; D050580:Excitatory Amino Acid Transporter 3; D050491:Glutamate Plasma Membrane Transport Proteins; D005971:Glutamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D008958:Models, Molecular; D008968:Molecular Conformation; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D018408:Patch-Clamp Techniques; D011869:Radioligand Assay; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013329:Structure-Activity Relationship; D027981:Symporters
D027322:Amino Acid Transport System X-AG; D002352:Carrier Proteins; D050580:Excitatory Amino Acid Transporter 3; D050491:Glutamate Plasma Membrane Transport Proteins; D005971:Glutamates; D018696:Neuroprotective Agents; C493398:Slc1a1 protein, rat; D027981:Symporters; D001224:Aspartic Acid; D012964:Sodium