Optic neuropathy in a patient with AIDS.
We present a patient with acquired immunodeficiency syndrome (AIDS) with bilateral sequential optic neuropathies attributed to the 14484 mutation of Leber hereditary optic neuropathy (LHON). We discuss the potential interaction of the mitochondrial mutation with antiretroviral therapy and review the literature.
Warner
J E
JE
Department of Ophthalmology and Visual Sciences, University of Utah Health Sciences Center, Salt Lake City, USA.
Ries
K M
KM
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects / Q000627:therapeutic use; D004252:DNA Mutational Analysis; D004272:DNA, Mitochondrial / Q000187:drug effects / Q000235:genetics; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000187:drug effects; D029242:Optic Atrophy, Hereditary, Leber / Q000175:diagnosis / Q000209:etiology* / Q000235:genetics; D014786:Vision Disorders / Q000175:diagnosis / Q000209:etiology / Q000235:genetics
D019380:Anti-HIV Agents; D004272:DNA, Mitochondrial