Quantification of 3-D regional myocardial deformation: shape-based analysis of magnetic resonance images.
A comprehensive three-dimensional (3-D) shape-based approach for quantification of regional myocardial deformations was evaluated in a canine model (n = 8 dogs) with the use of cine magnetic resonance imaging. The shape of the endocardial and epicardial surfaces was used to track the 3-D trajectories of a dense field of points over the cardiac cycle. The shape-based surface displacements are integrated with a continuum biomechanics model incorporating myofiber architecture to estimate both cardiac- and fiber-specific endocardial and epicardial strains and shears for 24 left ventricular regions. Whereas radial and circumferential end-systolic strains were fairly uniform, there was a significant apex-to-base gradient in longitudinal strain and radial-longitudinal shear. We also observed transmural epicardial-to-endocardial gradients in both cardiac- and fiber-specific strains. The increase in endocardial strain was accompanied by increases in radial-longitudinal shear and radial-fiber shears in the endocardium, supporting previous theories of regional myocardial deformation that predict considerable sliding between myocardial fibers.
Sinusas
A J
AJ
Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, Connecticut 06520-8042, USA. albert.sinusas@yale.edu
Papademetris
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X
Constable
R T
RT
Dione
D P
DP
Slade
M D
MD
Shi
P
P
Duncan
J S
JS
D000818:Animals; D004285:Dogs; D006321:Heart / Q000502:physiology*; D008279:Magnetic Resonance Imaging; D009200:Myocardial Contraction