Stem cell factor: biology and relevance to clinical practice.
The type III tyrosine kinase receptor c-KIT and its ligand stem cell factor (SCF; also known as KIT ligand, mast cell growth factor and steel factor) are closely involved in the regulation of a wide range of tissues at different stages of life. This review provides an outline of the discovery, structure and expression of SCF and c-KIT but concentrates on their respective roles in the regulation of human haemopoiesis and how this knowledge might be exploited in the clinical setting.
Smith
M A
MA
Department of Haematology, Royal United Hospital NHS Trust, Bath, UK.
Pallister
C J
CJ
Smith
J G
JG
D000818:Animals; D006402:Hematologic Diseases / Q000188:drug therapy; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D019009:Proto-Oncogene Proteins c-kit / Q000235:genetics / Q000494:pharmacology / Q000627:therapeutic use; D019089:Stem Cell Factor / Q000235:genetics / Q000502:physiology / Q000627:therapeutic use
D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit