title: Correlation of scalp EEG and 1H-MRS metabolic abnormalities in temporal lobe epilepsy.
abstract: OBJECTIVE
  To correlate the interictal spike field and region of seizure onset with the distribution of 1H-MRS abnormalities in temporal lobe epilepsy (TLE) and improve our understanding of the clinical significance of 1H-MRS abnormalities.
  
  
  METHODS
  Scalp electroencephalogram (EEG) monitoring and proton magnetic resonance spectroscopy (1H-MRS) results were correlated in 31 consecutive patients with TLE.
  
  
  RESULTS
  Lateralized 1H-MRS-based hippocampal abnormalities were recorded in 95% of the patients with unilateral interictal spikes, with a high degree of concordance for the lateralization side (90%). In 64% of the patients with normal or bilateral interictal EEG spikes, 1H-MRS provided lateralizing information. Bilateral 1H-MRS abnormalities, with or without lateralization, were 3 times more frequent than bitemporal EEG spikes. Anterior predominance of the 1H-MRS abnormalities was more frequent in patients with anterior temporal EEG spiking (50%), than in patients without this EEG distribution (18%). Similar association was noted between distribution of 1H-MRS abnormalities and region of EEG seizure onset.
  
  
  CONCLUSIONS
  Our results show a moderate level of concordance between the distribution of 1H-MRS and EEG abnormalities. 1H-MRS identifies abnormalities contralateral to the predominant seizure focus more often than does EEG and may provide lateralizing information in patients with nonlateralizing interictal EEG.
authors.affiliation: Department of Neurology, Center for Nuclear Imaging Research, University of Alabama at Birmingham, USA.
authors.forename: B
authors.initials: B
authors.lastname: Maton
authors.forename: F
authors.initials: F
authors.lastname: Gilliam
authors.forename: S
authors.initials: S
authors.lastname: Sawrie
authors.forename: E
authors.initials: E
authors.lastname: Faught
authors.forename: J
authors.initials: J
authors.lastname: Hugg
authors.forename: R
authors.initials: R
authors.lastname: Kuzniecky
mesh_terms: D000328:Adult; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D004569:Electroencephalography / Q000706:statistics & numerical data*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis* / Q000378:metabolism* / Q000401:mortality; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000378:metabolism* / Q000503:physiopathology; D006801:Humans; D006859:Hydrogen; D009682:Magnetic Resonance Spectroscopy / Q000706:statistics & numerical data*; D008297:Male; D013702:Temporal Lobe / Q000378:metabolism*
chemical_list: D006859:Hydrogen