title: Rotavirus-associated medical visits and hospitalizations in South America: a prospective study at three large sentinel hospitals.
abstract: BACKGROUND
  Knowledge of the impact of rotavirus-associated disease on the health care systems of South America can aid in defining strategies for diagnosis, management and prevention. Up to date information on the impact of rotavirus disease in South America is scarce.
  
  
  OBJECTIVE
  To determine prospectively the impact of rotavirus disease as a cause of medical visits and hospitalizations at three large sentinel pediatric hospitals in Argentina, Chile and Venezuela.
  
  
  METHODS
  A 2-year prospective surveillance for rotavirus-associated medical visits and hospitalizations was conducted during 1997 through 1998 at three large sentinel public hospitals, one each in Argentina, Chile and Venezuela. A common surveillance protocol was implemented at the three sites, and a representative number of nonbloody diarrhea stool samples from children <36 months of age were tested for rotavirus by enzyme-linked immunosorbent assay.
  
  
  RESULTS
  For our target age group, acute diarrhea-associated medical visits/hospitalizations represented 41%/2%, 5%/6% and 9%/13% of all medical visits/all hospitalizations at the Argentinean, Chilean and Venezuelan sites, respectively (P < 0.001 for difference among the three sites). Rotavirus detection rates among a total of 5,801/1,256 medical visit/hospitalization diarrhea stool samples tested were 39%/71% in Argentina, 34%/47% in Chile and 29%/38% in Venezuela (P < 0.01 by chi square for difference among the three sites). Rotavirus was associated with a mean of 1.5, 1.8 and 3% of total medical visits and 1.6, 2.8 and 5% of hospitalizations among children <36 months of age at the Argentinean, Chilean and Venezuelan sites, respectively. Seasonality was evident for medical visits at all three sites (although less striking in Chile) with peak activity occurring between November and May. Rotavirus-associated hospitalizations had a marked peak in Venezuela, represented largely by short stays, but not in Argentina and Chile.
  
  
  CONCLUSIONS
  Rotavirus was a significant cause of medical visits at all three sentinel sites. Rotavirus caused less hospitalizations than previously reported in Argentina and Chile. On the basis of our findings we estimate that approximately 106,000/ 21,000, 48,000/8,000 and 98,000/31,000 rotavirus-associated medical visits/hospitalizations occur yearly in Argentina, Chile and Venezuela, respectively.
authors.affiliation: Instituto de Ciencias Biomédicas, Faculty of Medicine, University of Chile, Santiago.
authors.forename: M
authors.initials: M
authors.lastname: O'Ryan
authors.forename: I
authors.initials: I
authors.lastname: Pérez-Schael
authors.forename: N
authors.initials: N
authors.lastname: Mamani
authors.forename: A
authors.initials: A
authors.lastname: Peña
authors.forename: B
authors.initials: B
authors.lastname: Salinas
authors.forename: G
authors.initials: G
authors.lastname: González
authors.forename: F
authors.initials: F
authors.lastname: González
authors.forename: D O
authors.initials: DO
authors.lastname: Matson
authors.forename: J
authors.initials: J
authors.lastname: Gómez
mesh_terms: D001118:Argentina / Q000453:epidemiology; D002675:Child, Preschool; D002677:Chile / Q000453:epidemiology; D003967:Diarrhea / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006760:Hospitalization / Q000706:statistics & numerical data*; D006776:Hospitals, Pediatric / Q000706:statistics & numerical data; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009819:Office Visits / Q000706:statistics & numerical data*; D011446:Prospective Studies; D012401:Rotavirus / Q000302:isolation & purification; D012400:Rotavirus Infections / Q000175:diagnosis / Q000191:economics / Q000453:epidemiology*; D018571:Sentinel Surveillance; D014687:Venezuela / Q000453:epidemiology