title: Immediate post-transplant nephrosis in a patient with congenital nephrotic syndrome.
abstract: A 19-month-old girl with congenital nephrotic syndrome of the Finnish type underwent a living-related renal transplant; 24 h after transplantation she became massively nephrotic. She did not respond to steroids, plasmapheresis, and high-dose cyclosporine. A month later, a renal biopsy showed only glomerular foot process effacement. She was treated with high-dose methylprednisolone pulses and oral cyclophosphamide. She rapidly went into complete remission with no further relapses. Graft function has been stable 2 years after transplantation.
authors.affiliation: Division of Pediatric Nephrology, UCLA Children's Hospital, Los Angeles, CA 90095-1752, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Barayan
authors.forename: S I
authors.initials: SI
authors.lastname: Al-Akash
authors.forename: M
authors.initials: M
authors.lastname: Malekzadeh
authors.forename: J L
authors.initials: JL
authors.lastname: Marik
authors.forename: A H
authors.initials: AH
authors.lastname: Cohen
authors.forename: R B
authors.initials: RB
authors.lastname: Ettenger
authors.forename: O
authors.initials: O
authors.lastname: Yadin
mesh_terms: D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008775:Methylprednisolone / Q000009:adverse effects / Q000627:therapeutic use; D009401:Nephrosis / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000151:congenital / Q000601:surgery*; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000893:Anti-Inflammatory Agents; D007166:Immunosuppressive Agents; D012709:Serum Albumin; D003520:Cyclophosphamide; D008775:Methylprednisolone