[Effect of marinobufagenin on the primary reinforcing effect of ethanol].
Intraperitoneal administration of marinobufagenin resulted in a reliable and dose-dependent suppression of ethanol self-administration in drug- and experimentally naive DBA/2 mice. The findings suggest that Na/K-ATPase contributes to both mediation of the ethanol reinforcing properties and the mood regulation.
Kashkin
V A
VA
St. Petersburg I. P. Pavlov State Medical University, 197022, St. Petersburg, Leo Tolstoy St., 6/8, Russia.
Patkina
N A
NA
Bagrov
A Ia
AIa
Bagrov
Ia Iu
IaIu
Zvartau
E E
EE
D000428:Alcohol Drinking / Q000523:psychology; D000818:Animals; D002018:Bufanolides / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D012054:Reinforcement, Psychology; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D002018:Bufanolides; D004791:Enzyme Inhibitors; C093896:marinobufagenin; D000254:Sodium-Potassium-Exchanging ATPase