Fatty acid transport proteins: a current view of a growing family.
Long-chain fatty acids (LCFAs) are a major caloric component of our diet and are key metabolites for energy generation and storage. Physiological uptake of LCFAs across cell membranes is a saturable and competable process occurring at low concentrations, indicative of protein-mediated transport. Fatty acid transport proteins are a family of transmembrane proteins that enhance LCFA uptake and are produced in all fatty acid-utilizing tissues. Here, we review our current understanding of the function, expression patterns and regulation and subcellular localization of this interesting family of proteins.
Stahl
A
A
The Whitehead Institute for Biomedical Research, Nine Cambridge Center, Cambridge, MA 02142-1479, USA.
Gimeno
R E
RE
Tartaglia
L A
LA
Lodish
H F
HF
D000818:Animals; D001692:Biological Transport; D002352:Carrier Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology; D050612:Fatty Acid Transport Proteins; D005227:Fatty Acids / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D008565:Membrane Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology; D026901:Membrane Transport Proteins; D013347:Subcellular Fractions / Q000737:chemistry
D002352:Carrier Proteins; D050612:Fatty Acid Transport Proteins; D005227:Fatty Acids; D008565:Membrane Proteins; D026901:Membrane Transport Proteins