title: Dipyridamole stress ultrasonic myocardial tissue characterization in patients with Kawasaki disease.
abstract: Dipyridamole stress integrated backscatter (IBS) was used for evaluation of myocardial ischemia or damage in 31 children with coronary artery lesions caused by Kawasaki disease, in comparison with thallium-201 myocardial imaging. All patients underwent echocardiography at rest and after dipyridamole stress at the anterior interventricular septum, posterior wall (PW), and inferior wall (INF). At rest, no significant difference was seen in cyclic variation (CV) of IBS in the regions with normal or abnormal distribution on Tl-201 imaging. But in the regions showing abnormal distribution after stress, CV decreased significantly. A delayed study after stress showed the recovery of CV to the level at rest in all patients. Sensitivity of abnormal cyclic variation integrated backscatter was 75% in the PW and 91% in the INF, and specificity was 91% in the PW and 90% in the INF, compared with the results of thallium-201 imaging. Dipyridamole stress IBS can provide sensitive detection of myocardial ischemia or damage in Kawasaki disease.
authors.affiliation: Department of Pediatrics, Toyama Medical & Pharmaceutical University, Toyama, Japan.
authors.forename: X
authors.initials: X
authors.lastname: Yu
authors.forename: I
authors.initials: I
authors.lastname: Hashimoto
authors.forename: F
authors.initials: F
authors.lastname: Ichida
authors.forename: Y
authors.initials: Y
authors.lastname: Hamamichi
authors.lastname: Uese Ki
authors.forename: S
authors.initials: S
authors.lastname: Tsubata
authors.forename: T
authors.initials: T
authors.lastname: Miyawaki
authors.forename: H
authors.initials: H
authors.lastname: Seto
authors.forename: D J
authors.initials: DJ
authors.lastname: Sahn
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004176:Dipyridamole; D004452:Echocardiography / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012680:Sensitivity and Specificity; D013794:Thallium Radioisotopes
chemical_list: D013794:Thallium Radioisotopes; D004176:Dipyridamole