Nematode-antagonistic trichothecenes from Fusarium equiseti.
A strain of the fungus Fusarium equiseti isolated from soybean cyst nematode secretes nematode-antagonistic compounds. Bioassay-guided fractionation of an extract of the culture broth was undertaken to identify the compounds. Fractions were assayed for activity against a root-knot nematode (Meloidogyne incognita), a plant pathogen that attacks the roots of numerous plant species. Two trichothecene compounds were isolated that inhibited egg hatch and immobilized second-stage juveniles of this nematode: 4,15-diacetoxy-12,13-epoxy-3,7-dihydroxytrichothec-9-en-8-one (4,15-diacetylnivalenol) and 4,15-diacetoxy-12,13-epoxy-trichothec-9-en-3-ol (diacetoxyscirpenol). This is the first published report of these compounds affecting plant-parasitic nematodes.
Nitao
J K
JK
Nematology Laboratory, USDA, ARS, Beltsville, Maryland 20705-2350, USA.
Meyer
S L
SL
Schmidt
W F
WF
Fettinger
J C
JC
Chitwood
D J
DJ
D000818:Animals; D001681:Biological Assay; D004531:Eggs; D005670:Fusarium / Q000737:chemistry*; D006790:Host-Parasite Interactions; D007814:Larva; D010571:Pest Control; D010944:Plants; D014255:Trichothecenes / Q000009:adverse effects / Q000494:pharmacology*; D014431:Tylenchoidea / Q000187:drug effects*
D014255:Trichothecenes