title: Neoadjuvant transjugular intrahepatic portosystemic shunt: a solution for extrahepatic abdominal operation in cirrhotic patients with severe portal hypertension.
abstract: BACKGROUND
  Major abdominal surgery, although technically feasible per se, can be contraindicated in some cirrhotic patients because of severe portal hypertension. The present study reports our experience of seven such patients who were prepared for major abdominal surgery by transjugular intrahepatic portosystemic shunt (TIPS).
  
  
  METHODS
  There were seven cirrhotic patients (six men and one woman aged 47 to 69 years) with portal hypertension. Portal hypertension was considered severe because of the presence of at least one of the following: history of variceal bleeding (five of seven patients), varices at risk of bleeding (red signs or cardial location of varices; four of seven patients), or intractable ascites (three of seven patients). The planned operations included colon, gastroesophageal, kidney, and aortic procedures in three, two, one, and one patient, respectively. Because portal hypertension was the leading cause of surgical contraindication, the following "two-step strategy" was applied to the seven patients: first, TIPS to control portal hypertension, followed, after a delay of at least 1 month, by abdominal surgery.
  
  
  RESULTS
  The TIPS procedure was successfully performed in all patients without complications. The hepatic venous pressure gradient decreased from 18+/-5 to 9+/-5 mm Hg (p<0.01). All patients were operated on with a delay ranging from 1 month to 5 months after TIPS (2.9+/-1.3 months; median 3 months). The planned operation was performed in six of the seven patients. One patient with cancer of the cardia did not have resection because of extensive abdominal spreading of the tumor. Intraoperative transfusion was necessary in only two patients. Operative mortality occurred in one patient, 36 days after resection of a left colon cancer.
  
  
  CONCLUSIONS
  The minimally invasive nature of TIPS allows us to propose the following two-step management of cirrhotic patients with severe portal hypertension needing abdominal surgery: decompression of the portal system by TIPS followed by elective surgery.
authors.affiliation: Centre Hépatobiliaire, Université Paris, Sud, Hĵpital Paul Brousse, Villejuif, France.
authors.forename: D
authors.initials: D
authors.lastname: Azoulay
authors.forename: F
authors.initials: F
authors.lastname: Buabse
authors.forename: I
authors.initials: I
authors.lastname: Damiano
authors.forename: A
authors.initials: A
authors.lastname: Smail
authors.forename: P
authors.initials: P
authors.lastname: Ichai
authors.forename: M
authors.initials: M
authors.lastname: Dannaoui
authors.forename: D
authors.initials: D
authors.lastname: Castaing
authors.forename: H
authors.initials: H
authors.lastname: Bismuth
mesh_terms: D000008:Abdominal Neoplasms / Q000601:surgery*; D000368:Aged; D000075202:Contraindications; D017558:Elective Surgical Procedures; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D019168:Portasystemic Shunt, Transjugular Intrahepatic; D011183:Postoperative Complications / Q000453:epidemiology; D012307:Risk Factors; D013514:Surgical Procedures, Operative; D013997:Time Factors