title: Role for p53 in gene induction by double-stranded RNA.
abstract: Cross talk between p53 and interferon-regulated pathways is implicated in the induction of gene expression by biologic and genotoxic stresses. We demonstrate that the interferon-stimulated gene ISG15 is induced by p53 and that p53 is required for optimal gene induction by double-stranded RNA (dsRNA), but not interferon. Interestingly, virus induces ISG15 in the absence of p53, suggesting that virus and dsRNA employ distinct signaling pathways.
authors.affiliation: Greenebaum Cancer Center, The University of Maryland, Baltimore, Maryland 21201, USA.
authors.forename: B T
authors.initials: BT
authors.lastname: Hummer
authors.forename: X L
authors.initials: XL
authors.lastname: Li
authors.forename: B A
authors.initials: BA
authors.lastname: Hassel
mesh_terms: D000818:Animals; D002460:Cell Line; D015967:Gene Expression Regulation, Viral; D016158:Genes, p53; D007372:Interferons / Q000235:genetics*; D051379:Mice; D012313:RNA / Q000235:genetics*; D012367:RNA, Viral / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics; D015533:Transcriptional Activation
chemical_list: D012367:RNA, Viral; D012313:RNA; D007372:Interferons