Angiogenesis-dependent diseases and angiogenesis therapy.
The discovery of the molecular mechanisms of physiological vasculogenesis and pathological angiogenesis helped to recognize two classes of diseases: one where the therapeutic angiogenesis can repair the tissue damages (arteriosclerosis, myocardial infarction, limb ischemia) and the other one where inhibition of pathological angiogenesis can cure the disease or delay its progression (retinopathies, benign and malignant angiogenic tumors, progression of malignant tumors). Although there are an exponentially growing number of new synthetic molecules characterized mainly by antiangiogenic properties, the discovery of a large battery of natural pro- and anti-angiogenic factors suggests that this may provide a more physiological approach to treat both class of angiogenesis-dependent diseases in the near future.
Tímár
J
J
National Institute of Oncology, Department of Tumor Progression Ráth Gy. U. 7-9., Budapest, H1122, Hungary. 36 1 224 8786, 36 1 224 8620. jtimar@oncol.hu
Döme
B
B
Fazekas
K
K
Janovics
A
A
Paku
S
S
D020533:Angiogenesis Inhibitors / Q000627:therapeutic use*; D000818:Animals; D001161:Arteriosclerosis / Q000188:drug therapy / Q000473:pathology; D002642:Chick Embryo; D003097:Collateral Circulation / Q000187:drug effects; D016228:Endothelial Growth Factors / Q000502:physiology; D004730:Endothelium, Vascular / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008222:Lymphokines / Q000502:physiology; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D012164:Retinal Diseases / Q000188:drug therapy / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000188:drug therapy / Q000473:pathology; D015398:Signal Transduction / Q000187:drug effects; D013683:Telangiectasia, Hereditary Hemorrhagic / Q000188:drug therapy / Q000473:pathology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D006623:von Hippel-Lindau Disease / Q000188:drug therapy / Q000473:pathology
D020533:Angiogenesis Inhibitors; D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors