Annotated draft genomic sequence from a Streptococcus pneumoniae type 19F clinical isolate.
The public availability of numerous microbial genomes is enabling the analysis of bacterial biology in great detail and with an unprecedented, organism-wide and taxon-wide, broad scope. Streptococcus pneumoniae is one of the most important bacterial pathogens throughout the world. We present here sequences and functional annotations for 2.1-Mbp of pneumococcal DNA, covering more than 90% of the total estimated size of the genome. The sequenced strain is a clinical isolate resistant to macrolides and tetracycline. It carries a type 19F capsular locus, but multilocus sequence typing for several conserved genetic loci suggests that the strain sequenced belongs to a pneumococcal lineage that most often expresses a serotype 15 capsular polysaccharide. A total of 2,046 putative open reading frames (ORFs) longer than 100 amino acids were identified (average of 1,009 bp per ORF), including all described two-component systems and aminoacyl tRNA synthetases. Comparisons to other complete, or nearly complete, bacterial genomes were made and are presented in a graphical form for all the predicted proteins.
Dopazo
J
J
Research Department, GlaxoSmithKline S.A., Tres Cantos, Spain.
Mendoza
A
A
Herrero
J
J
Caldara
F
F
Humbert
Y
Y
Friedli
L
L
Guerrier
M
M
Grand-Schenk
E
E
Gandin
C
C
de Francesco
M
M
Polissi
A
A
Buell
G
G
Feger
G
G
García
E
E
Peitsch
M
M
García-Bustos
J F
JF
D004269:DNA, Bacterial / Q000737:chemistry / Q000235:genetics; D005798:Genes, Bacterial / Q000235:genetics; D016680:Genome, Bacterial; D008969:Molecular Sequence Data; D011008:Pneumococcal Infections / Q000382:microbiology*; D011387:Prokaryotic Cells; D012343:RNA, Transfer / Q000378:metabolism; D013296:Streptococcus pneumoniae / Q000235:genetics*
D004269:DNA, Bacterial; D012343:RNA, Transfer