[Changes in the activity of enzymes of heme synthesis and catabolism, and level of microsomal hemoproteins during the liver acute intoxication by thioacetamide].
Thioacetamide administration to rats (20 mg/100 g) caused the development of toxic hepatitis which was accompanied by the increase of hepatic ALA-synthase and D-ALA that led to accumulating free porphyrines in the liver. At the same time an increase in activity of heme oxigenase was also found. A decrease in heme synthesis correlated with a decrease in content of cytochrome P450 and b5 in microsomal hepatic fraction of experimental animals.
Kharimov
Kh Ia
KhIa
Second Tashkent State Medical Institute, 700109, 2 Farabi Street, Main Training Building 2nd TashMI.
Inoiatova
F Kh
FKh
Dolimova
M A
MA
D000208:Acute Disease; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D005294:Ferrochelatase / Q000378:metabolism; D006418:Heme / Q000096:biosynthesis / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D000623:Porphobilinogen Synthase / Q000378:metabolism; D051381:Rats; D013853:Thioacetamide
D013853:Thioacetamide; D006418:Heme; D006419:Heme Oxygenase (Decyclizing); D000623:Porphobilinogen Synthase; D005294:Ferrochelatase