Increased von Willebrand factor in migraine.
The authors determined von Willebrand factor (vWF) in 63 persons with migraine, 11 persons with migraine and prior stroke, and 35 frequency-matched controls. Additional studies were done in a subset with migraine without aura who were headache free for >7 days. Migraineurs with prior stroke had significantly higher vWF antigen (170% versus 106%) and activity (162% versus 108%) than the control group. vWF antigen (126%) and activity (130%) were also significantly higher in migraineurs without stroke. Multimers and protease activity were normal in the interictal subset.
Tietjen
G E
GE
Department of Neurology, Medical College of Ohio, Toledo, USA. gtietjen@mco.edu
Al-Qasmi
M M
MM
Athanas
K
K
Dafer
R M
RM
Khuder
S A
SA
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000150:complications; D012307:Risk Factors; D020521:Stroke / Q000097:blood* / Q000150:complications; D014841:von Willebrand Factor / Q000378:metabolism*
D014841:von Willebrand Factor