Structural features of trinucleotide repeats associated with DNA expansion.
The mechanism of DNA expansion is not well understood. Recent evidence from genetic, in vivo, and in vitro studies has suggested a link between the formation of alternative DNA secondary structures by trinucleotide repeat tracts and their propensity to undergo expansion. This review will focus on structural features and the mechanism of expansion relevant to human disease.
Kovtun
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Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Goellner
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McMurray
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CT
D000818:Animals; D004247:DNA / Q000235:genetics* / Q000378:metabolism; D004260:DNA Repair; D004261:DNA Replication / Q000235:genetics; D006801:Humans; D019636:Neurodegenerative Diseases / Q000235:genetics; D009690:Nucleic Acid Conformation; D019680:Trinucleotide Repeat Expansion / Q000235:genetics*
D004247:DNA