title: Substituted 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives as antagonists for the adenosine A(1) receptor.
abstract: The synthesis and receptor binding of novel adenosine receptor antagonists is described. We found that non-xanthine 4-phenyl-2-(phenylcarboxamido)-1,3-thiazole derivatives may have high affinity and substantial selectivity for the adenosine A(1) receptor.
authors.affiliation: Leiden/Amsterdam Center for Drug Research, Division of Medicinal Chemistry, PO Box 9502, 2300 RA, Leiden, The Netherlands.
authors.forename: E W
authors.initials: EW
authors.lastname: van Tilburg
authors.forename: P A
authors.initials: PA
authors.lastname: van der Klein
authors.forename: M
authors.initials: M
authors.lastname: de Groote
authors.forename: M W
authors.initials: MW
authors.lastname: Beukers
authors.forename: A P
authors.initials: AP
authors.lastname: IJzerman
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D011485:Protein Binding / Q000502:physiology; D058915:Purinergic P1 Receptor Antagonists; D051381:Rats; D043705:Receptor, Adenosine A2A; D043684:Receptor, Adenosine A3; D018047:Receptors, Purinergic P1 / Q000187:drug effects*; D013844:Thiazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D014793:Visual Cortex / Q000166:cytology / Q000378:metabolism
chemical_list: D058915:Purinergic P1 Receptor Antagonists; D043705:Receptor, Adenosine A2A; D043684:Receptor, Adenosine A3; D018047:Receptors, Purinergic P1; D013844:Thiazoles