The regulation of sympathetic outflow in heart failure. The roles of angiotensin II, nitric oxide, and exercise training.
Sympatho-excitation is a hallmark of the chronic heart failure (CHF) state. It has long been assumed that this sympatho-excitation is mediated by a reduction in sensory input from cardiopulmonary and arterial baroreceptors. However, recent data suggest that these reflexes may only be important in the initiation of the sympatho-excitatory state and may not be necessary for the sustained increase in sympathetic nerve activity (SNA) in CHF. Two humoral factors that can influence SNA are nitric oxide (NO) and angiotensin II (AngII). Animals with CHF exhibit a downregulation in central gene expression for the neuronal isoform of nitric oxide synthase (nNOS). In addition, blockade of AngII receptors in combination with NO donation reduces SNA in animals with CHF, while NO donation alone has no effect on SNA. Chronic exercise training (EX) reduces both plasma AngII and SNA in rabbits with CHF while improving baroreflex function. Blockade of AT1 receptors enhances baroreflex function in non-EX CHF rabbits, but has little effect in EX CHF rabbits. These data suggest that the sympatho-excitatory state that is typical of CHF is, in part, due to changes in AngII and NO. Depressed baroreflex function and the elevated SNA can be improved by EX in animals with CHF.
Zucker
I H
IH
Department of Physiology and Biophysics, University of Nebraska Medical Center, 984575 Nebraska Medical Center, Omaha, NE 68198-4575, USA. izucker@unmc.edu
Wang
W
W
Pliquett
R U
RU
Liu
J L
JL
Patel
K P
KP
D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D002303:Cardiac Output, Low / Q000503:physiopathology*; D002908:Chronic Disease; D019332:Endothelin-1 / Q000502:physiology; D009569:Nitric Oxide / Q000502:physiology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D019332:Endothelin-1; D000804:Angiotensin II; D009569:Nitric Oxide