[Follow-up survey of dioxins in the blood of Yusho patients (in 1998-1999)].
Follow-up survey of the blood concentration of PCDDs, PCDFs and non-ortho-chlorine substituted PCBs in Yusho patients is very important for their health control. We determined the blood concentration of these dioxin isomers in 119 blood samples collected in 1998 and 1999 using by a high-resolution gas chromatograph/high-resolution mass spectrometry (HRGC/HRMS). Thirty years had passed since the Yusho occurrence, and the total blood concentrations of PCDFs in the blood of Yusho patients were still as high as ever, except the patients with the PCB pattern C. Among the different groups of PCB patterns, the concentration of 2,3,4,7,8-PeCDF, 1,2,3,4,7,8-HxCDF and 1,2,3,6,7,8-HxCDF showed significant differences, excluding the group BC because of the small number of cases. The findings indicate that these isomers are not decomposed in human body since they had highly contaminated the causal rice oil at the onset. In typical Yusho patients (Group A of PCB pattern), the mean TEQ concentrations of PCDDs, PCDFs and non-ortho-chlorine substituted PCBs in the blood collected in 1998 were 21, 206, and 14 pg-TEQ/g lipid, respectively, and in 1999, 30, 308 and 14 pg-TEQ/g lipid, respectively. The toxic contribution rate of PCDFs TEQ was still at high levels for total TEQ in both years. The patients of the group C, however, the mean blood levels of the dioxins TEQ in 1998 and 1999 did not differ from those of the normal controls determined in 1996 although some patients in this group showed a high toxic contribution rate of PCDFs TEQ for total TEQ. We will try the PCB isomer specific analysis of the Yusho patients blood, and will investigate the difference from normal controls blood.
Takenaka
S
S
Fukuoka Institute of Health & Environmental Sciences, 39 Mukaizano, Dazaifu, Fukuoka 818-0135.
Hirakawa
H
H
Nakamura
M
M
Nakagawa
R
R
Iida
T
T
Todaka
T
T
D001572:Benzofurans / Q000097:blood; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins / Q000097:blood*; D005500:Follow-Up Studies; D005506:Food Contamination; D006801:Humans; D012275:Oryza / Q000506:poisoning*; D010938:Plant Oils / Q000506:poisoning*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives / Q000097:blood; D011506:Proteins / Q000506:poisoning*; D014598:Uteroglobin
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004147:Dioxins; D010938:Plant Oils; D000072317:Polychlorinated Dibenzodioxins; D011506:Proteins; C556389:SCGB1A1 protein, human; D014598:Uteroglobin