Repetitive mucosal trauma promotes colon cancer in experimental rat model.
OBJECTIVE
To investigate the effect of repetitive mucosal trauma, anastomosis and intestinal content on experimental colonic carcinogenesis as there is the possibility than non-specific colon lesions can promote cancer.


METHODS
We performed to sixty female Sprague-Dawley rats a 4 cm colon loop defunctionalization with double colostomy (traumatic site). Intestinal continuity was restored with an end-to-end colo-colic silk anastomosis. The surviving 47 rats were divided in 3 groups: Group A: 27 rats treated with DMH. Group B: 10 rats treated with EDTA and Group C: Control of 10 rats. Animals were sacrificed 31-32 weeks after surgery for macro and micropathological studies.


RESULTS
In group A appeared 60 tumours: 44 in the functional colon, 20 of them in the anastomotic site; 8 in the non traumatised defunctionalized segment and 18 in the traumatised segment (p < 0.05).


CONCLUSIONS
a) Continuous microtraumas on colonic mucosa in rats are cancer promotional factors; b) silk suture in anastomosis promotes cancer.
Viñas Salas
J
J
Departments of Medicine and Surgery, Lleida University School of Medicine, Arnau de Vilanova University Hospital, Lleida, Spain. jvinyes@arnau.scs.es
Piñol Felis
C
C
Fermiñan
A
A
Egido
R
R
Pérez-Holanda
S
S
Biendicho
P
P
Buenestado
J
J
Reñé Espinet
J
J
D000714:Anastomosis, Surgical; D000818:Animals; D003110:Colonic Neoplasms / Q000473:pathology*; D005260:Female; D007413:Intestinal Mucosa / Q000293:injuries* / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley