Protective effect of Hemidesmus indicus against rifampicin and isoniazid-induced hepatotoxicity in rats.
Oral treatment with the ethanol extract of Hemidesmus indicus roots (100 mg/kg, for 15 days) significantly prevented rifampicin and isoniazid-induced hepatotoxicity in rats.
Prabakan
M
M
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India.
Anandan
R
R
Devaki
T
T
D000284:Administration, Oral; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000517:prevention & control*; D007538:Isoniazid / Q000633:toxicity; D019684:Magnoliopsida; D008297:Male; D008515:Medicine, Ayurvedic; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin / Q000633:toxicity
D010936:Plant Extracts; D007538:Isoniazid; D012293:Rifampin