Neither perirhinal/entorhinal nor hippocampal lesions impair short-term auditory recognition memory in dogs.
Visual, tactile, and olfactory recognition memory in animals is mediated in part by the perirhinal/entorhinal (or rhinal) cortices and, possibly, the hippocampus. To examine the role of these structures in auditory memory, we performed rhinal, hippocampal, and combined lesions in groups of dogs trained in auditory delayed matching-to-sample with trial-unique sounds. The sample sound was presented through a central speaker and, after a delay, the sample sound and a different sound were played alternately through speakers placed on either side of the animal; the animal was rewarded for responding to the side emitting the sample sound. None of the lesion groups showed significant impairment in comparison either to their own preoperative performance or to the performance of intact control dogs. This was the case both for relearning the delayed matching rule at a delay of 1.5 s and for task performance at variable delays ranging from 10 to 90 s. From these findings we suggest that the tissue critical for auditory recognition memory is located outside both the perirhinal/entorhinal cortices and the hippocampus.
Kowalska
D M
DM
Department of Neurophysiology, Nencki Institute of Experimental Biology, Pasteur Street 3, 02-093 Warsaw, Poland. dmk@nencki.gov.pl
Kuśmierek
P
P
Kosmal
A
A
Mishkin
M
M
D000647:Amnesia / Q000473:pathology / Q000503:physiopathology; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology*; D003714:Denervation; D004195:Disease Models, Animal; D004285:Dogs; D018728:Entorhinal Cortex / Q000166:cytology / Q000502:physiology* / Q000601:surgery; D006624:Hippocampus / Q000166:cytology / Q000502:physiology* / Q000601:surgery; D008297:Male; D008570:Memory, Short-Term / Q000502:physiology*; D011597:Psychomotor Performance / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D021641:Recognition, Psychology / Q000502:physiology*