[Immunomodulatory properties of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate and search for its new derivatives].
A strong immunomodulatory effect of 2-C-methyl-D-erythritol-2,4-cyclopyrophosphate (MEC) responsible for the survival of bacteria was shown on isolated macrophages and in experimental infections in mice (typhoid and tularemia). Derivatives of MEC were found by 1H-NMR spectroscopy under stress conditions in colorless mutants of the bacteria and isolated to be subsequently purified and used for modulation of the immune system of animals.
Potapov
V D
VD
State Research Center of Applied Microbiology, Obolensk, Moscow oblast, Russia.
Biketov
S F
SF
Demina
G R
GR
Lysak
E I
EI
Titareva
G M
GM
Bakhteeva
I V
IV
Ostrovskiĭ
D N
DN
D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D003352:Corynebacterium; D004896:Erythritol / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis / Q000187:drug effects; D014406:Tularemia / Q000276:immunology; D014435:Typhoid Fever / Q000276:immunology
D000276:Adjuvants, Immunologic; C073443:2-methyl-butan-1,2,3,4-tetraol-2,4-cyclopyrophosphate; D004896:Erythritol