title: [Clinical relevance of unusual metastases from colorectal neoplasms].
abstract: BACKGROUND
  The aim of the study was to evaluate the clinical relevance of isolated metastases (MII) in unusual sites (different from liver and lung), synchronous and metachronous, in patients operated on for colorectal carcinoma (CCR).
  
  
  METHODS
  The study was performed on 655 patients who underwent surgery for CCR during the period 1985-2000. Work out for distance metastases was performed (both during preoperative evaluation and follow-up) with physical examination and other few exams (CEA, chest X-ray, abdominal US scan). Other investigations were carried out if requested by clinical features. Metastases localized in sites different from liver and lungs were considered unusual.
  
  
  RESULTS
  Metastases in unusual sites usually are observed in patients with terminal neoplastic disease. MII was found in only 7 (1.07%) patients, all submitted to resection of the primary tumor. Sites of unusual metastases were bones (3), CNS (2), adrenal gland and anus; such lesions were easily diagnosed by clinical features or by few examinations. Curative treatment was feasible in only three patients, and actually it did improve neither survival, nor quality of life.
  
  
  CONCLUSIONS
  Extra-abdominal MII are rare, generally they cannot be treated; therefore particular tests for early diagnosis of such lesions appear useless. Potentially curative surgery for splenic and adrenal metastases is described in the literature; anyhow these lesions are usually shown by routine investigations.
authors.affiliation: Chirurgia Generale II, Ospedale Binaghi, Università degli Studi, Cagliari, Italy. mvmelis@tiscalinet.it
authors.forename: M
authors.initials: M
authors.lastname: Melis
authors.forename: F
authors.initials: F
authors.lastname: Scintu
authors.forename: M
authors.initials: M
authors.lastname: Pisano
authors.forename: F
authors.initials: F
authors.lastname: Capra
authors.forename: L
authors.initials: L
authors.lastname: Marongiu
authors.forename: P
authors.initials: P
authors.lastname: Mocci
authors.forename: G
authors.initials: G
authors.lastname: Casula
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis