title: Small is mighty: EmrE, a multidrug transporter as an experimental paradigm.
abstract: EmrE is a multidrug transporter from Escherichia coli that functions as a homooligomer and is unique in its small size. In each monomer there are four tightly packed transmembrane segments and one membrane-embedded charged residue. This residue provides the basis for the coupling mechanism as part of a binding site "time shared" by substrates and protons.
authors.affiliation: Alexander Silberman Institute of Life Sciences, Hebrew University of Jerusalem, 91904 Jerusalem, Israel. shimon.schuldiner@huji.ac.il
authors.forename: S
authors.initials: S
authors.lastname: Schuldiner
authors.forename: D
authors.initials: D
authors.lastname: Granot
authors.forename: S S
authors.initials: SS
authors.lastname: Mordoch
authors.forename: S
authors.initials: S
authors.lastname: Ninio
authors.forename: D
authors.initials: D
authors.lastname: Rotem
authors.forename: M
authors.initials: M
authors.lastname: Soskin
authors.forename: C G
authors.initials: CG
authors.lastname: Tate
authors.forename: H
authors.initials: H
authors.lastname: Yerushalmi
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D017920:Antiporters / Q000235:genetics / Q000502:physiology*; D002352:Carrier Proteins / Q000502:physiology*; D029968:Escherichia coli Proteins; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D004364:Pharmaceutical Preparations / Q000378:metabolism*
chemical_list: D017920:Antiporters; D002352:Carrier Proteins; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; D004364:Pharmaceutical Preparations; C075436:EmrE protein, E coli