title: Novel polymeric membranes having chiral recognition sites converted from tripeptide derivatives.
abstract: Six kinds of tripeptide derivative consisting of L-glutamic acid gamma-benzyl ester [Glu(OBzl)] (E) and L-phenylalanine (Phe) (F), i.e. EEF, EFE, FEE, FEF, FFE and FFF, were converted into chiral recognition sites by adopting Boc-L-Trp as a print molecule. The formed chiral recognition sites discriminated between Ac-L-Trp and the corresponding D-isomer, and the L-isomer was incorporated into the membrane in preference to the D-isomer. The affinity constants between the recognition site formed in each membrane and Ac-L-Trp were determined to be 9.6 x 10(3) to 8.4 x 10(3) mol-1 dm3. The affinity constant depends on both the tripeptide sequence and the amino acid residue content. Tripeptide derivatives containing more glutamic acid derivative residues or glutamic acid derivative as an amino-terminal residue show higher affinity constants.
authors.affiliation: Department of Polymer Science and Engineering, Kyoto Institute of Technology, Matsugasaki, Kyoto 606-8585, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: A
authors.initials: A
authors.lastname: Shimada
authors.forename: J
authors.initials: J
authors.lastname: Izumi