title: Qualitative and quantitative analyses of resin-bound organic compounds.
abstract: Methods for qualitative and quantitative analyses of resin-bound organic compounds are essential tools for chemistry development in solid-phase combinatorial and parallel syntheses. Here we discuss the use of gel-phase 19F NMR, the fluoride ion-selective electrode method, and spectrophotometry for monitoring solid-phase reactions. Our results indicate that the application of these diverse methods for analyzing the outcome of solid-phase combinatorial synthesis are sensitive and conclusive.
authors.affiliation: ChemRx Advanced Technologies, 385 Oyster Point Boulevard, South San Francisco, CA 94080, USA.
authors.forename: M
authors.initials: M
authors.lastname: Irving
authors.forename: J
authors.initials: J
authors.lastname: Cournoyer
authors.forename: R
authors.initials: R
authors.lastname: Li
authors.forename: C
authors.initials: C
authors.lastname: Santos
authors.forename: B
authors.initials: B
authors.lastname: Yan
mesh_terms: D000447:Aldehydes / Q000032:analysis / Q000737:chemistry; D002264:Carboxylic Acids / Q000032:analysis / Q000737:chemistry; D002625:Chemistry, Organic / Q000379:methods*; D020650:Combinatorial Chemistry Techniques; D004563:Electrochemistry / Q000295:instrumentation / Q000379:methods*; D005453:Fluorescence; D005459:Fluorides / Q000032:analysis / Q000737:chemistry; D017611:Fluorine Compounds / Q000032:analysis / Q000737:chemistry; D005462:Fluorine Radioisotopes / Q000737:chemistry; D017736:Ion-Selective Electrodes; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D012116:Resins, Plant / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet / Q000379:methods*; D017550:Spectroscopy, Fourier Transform Infrared / Q000379:methods
chemical_list: D000447:Aldehydes; D002264:Carboxylic Acids; D017611:Fluorine Compounds; D005462:Fluorine Radioisotopes; D012116:Resins, Plant; D005459:Fluorides