title: Association between apolipoprotein B promotor haplotypes and cholesterol status.
abstract: Association between apolipoprotein B (apo B) promoter haplotypes and cholesterol concentration was studied in two groups of children with low and high concentrations of cholesterol. Strong linkage equilibrium was demonstrated between I/D in the signal peptide of apo B and (C-516T) polymorphism in the promotor of apo B gene, and the I/I+ allele T haplotype was associated with a low cholesterol concentration.
authors.affiliation: Laboratory of Atherosclerosis Research, Institute for Clinical and Experimental Medicine, Prague, Czech Republic. jaroslav.hubacek@medicon.cz
authors.forename: J A
authors.initials: JA
authors.lastname: Hubacek
authors.forename: H
authors.initials: H
authors.lastname: Pistulková
authors.forename: Z
authors.initials: Z
authors.lastname: Skodová
authors.forename: K
authors.initials: K
authors.lastname: Berg
authors.forename: R
authors.initials: R
authors.lastname: Poledne
mesh_terms: D001055:Apolipoproteins B / Q000235:genetics*; D002648:Child; D002784:Cholesterol / Q000097:blood*; D004247:DNA / Q000097:blood; D006239:Haplotypes; D006801:Humans; D015810:Linkage Disequilibrium; D020641:Polymorphism, Single Nucleotide; D011401:Promoter Regions, Genetic; D021382:Protein Sorting Signals
chemical_list: D001055:Apolipoproteins B; D021382:Protein Sorting Signals; D004247:DNA; D002784:Cholesterol