Cholesterol catabolism in patients with acute myelogenous leukemia and hypocholesterolemia: suppressed levels of a circulating marker for bile acid synthesis.
Hypocholesterolemia is a frequent finding in patients with acute myelogenous leukemia (AML) and in other types of malignancies. Since bile acids are major excretion products of cholesterol, the hepatic degradation of cholesterol to bile acids was investigated in AML patients by analyzing a circulating marker for bile acid synthesis. In addition, plasma levels of a marker for cholesterol synthesis were determined. The plasma levels of 7alpha-hydroxy-4-cholesten-3-one, reflecting bile acid production, were markedly lower in patients with AML than in healthy controls. The median levels were 3.3 and 18.5ng/ml (P<0.0001) in the AML patients (n=29) and the healthy subjects (n=16), respectively. The plasma levels of 7-dehydrocholesterol, reflecting hepatic cholesterol synthesis, were similar for the AML patients and the controls. The results show that the conversion of cholesterol to bile acids was suppressed in AML patients, a phenomenon that may result in a decreased intestinal absorption of cholesterol and subsequent hypocholesterolemia.
Tatidis
L
L
Division of Clinical Pharmacology, Department of Medicine, Karolinska Institute and Hospital, S-171 76 Stockholm, Sweden. lota@mb.ks.se
Vitols
S
S
Gruber
A
A
Paul
C
C
Axelson
M
M
D000368:Aged; D001647:Bile Acids and Salts / Q000096:biosynthesis*; D015415:Biomarkers / Q000032:analysis; D002783:Cholestenones / Q000097:blood; D002784:Cholesterol / Q000097:blood* / Q000378:metabolism; D003684:Dehydrocholesterols / Q000097:blood; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D015470:Leukemia, Myeloid, Acute / Q000097:blood*; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D001647:Bile Acids and Salts; D015415:Biomarkers; D002783:Cholestenones; D003684:Dehydrocholesterols; D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL; C002656:7 alpha-hydroxy-4-cholesten-3-one; D002784:Cholesterol; C016705:7-dehydrocholesterol