title: An evaluation of breathing nervous regulation of opiate dependent patients during in 6 months' methadone maintenance treatment programme.
abstract: During the methadone maintenance treatment an individually specified doses of methadone should prevent a withdrawal syndrome and may stabilise the activity of respiratory centres of opiate dependent patients. The aim of the study was to evaluate the direction of changes in respiratory pattern parameters of 34 opiate dependent patients (14 women and 20 men) during 6 months' methadone maintenance treatment at the Kraków Department of Clinical Toxicology. Respiratory pattern parameters and occlusion pressure were measured by means of a computer spirometer using "on line" during unrestrained breathing with atmospheric air. Examination of respiratory pattern were performed three times: I--initial examination--before administration of methadone maintenance treatment; II--control examination after 3 months' methadone maintenance treatment; III--control examination after 6 months' methadone maintenance treatment. An increase in values of occlusion pressure and minute ventilation were observed. The times of expiration and total times of inspiration-expiration cycle were shorter in III examination than in the examination before methadone administration. The values for the breathing cycle neuromuscular drive (VT/Tin) were relatively stable, but they were higher than those obtained in the control group. It may be related to the anxiety states and mood alteration. The largest individual variation in consecutive examination were observed for Tin/Ttot index being the timing component of respiratory patterns characteristic for parasympathetic control of breathing.
authors.affiliation: Department of Hygiene and Ecology, College of Medicine, Jagiellonian University, Kraków, Poland.
authors.forename: E
authors.initials: E
authors.lastname: Kolarzyk
authors.forename: D
authors.initials: D
authors.lastname: Targosz
authors.forename: D
authors.initials: D
authors.lastname: Pach
mesh_terms: D000328:Adult; D001007:Anxiety / Q000150:complications / Q000503:physiopathology; D005260:Female; D006801:Humans; D008168:Lung / Q000294:innervation*; D008297:Male; D008691:Methadone / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D009293:Opioid-Related Disorders / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests
chemical_list: D008691:Methadone