Muscle metaboreflex control is diminished in normotensive obese women.
There is no information about the muscle metaboreflex control in obese individuals. In 40 normotensive obese women (OW; body mass index 33.5 +/- 0.4 kg/m2, age 32.4 +/- 1.1 yr) and 15 age-matched, normotensive lean women (LW; body mass index 22.7 +/- 0.8 kg/m2, age 34.4 +/- 1.4 yr), we measured muscle sympathetic nerve activity (MSNA) and forearm blood flow (FBF) in the nonexercising forearm during static exercise at 10 and 30% of maximal voluntary contraction (MVC). Baseline MSNA (38 +/- 2 vs. 31 +/- 1 bursts/min, P = 0.001) and mean blood pressure were significantly higher in OW compared with LW. FBF was significantly lower, whereas forearm vascular resistance was significantly higher in OW. During 10% MVC, MSNA increased similarly in both groups, but during 30% MVC, MSNA was higher in LW. FBF and forearm vascular resistance responses during both 10 and 30% MVC were similar between groups. During posthandgrip circulatory arrest, MSNA remained significantly elevated compared with baseline in both groups, but this increase was significantly lower in OW (3.8 +/- 0.82 vs. 9.4 +/- 1.03 bursts/min, P = 0.002). In conclusion, muscle metaboreflex control of MSNA is blunted in OW. MSNA responses are not augmented during selective activation of central command/mechanoreceptors and metaboreceptors, despite increased MSNA levels in OW. Muscle vasodilatory response during graded handgrip isometric exercise is preserved in OW.
Negrão
C E
CE
Heart Institute (InCor), São Paulo, Cep 05403-000 Brazil. cndnegrao@incor.usp.br
Trombetta
I C
IC
Batalha
L T
LT
Ribeiro
M M
MM
Rondon
M U
MU
Tinucci
T
T
Forjaz
C L
CL
Barretto
A C
AC
Halpern
A
A
Villares
S M
SM
D000328:Adult; D015444:Exercise; D005260:Female; D006801:Humans; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000294:innervation* / Q000503:physiopathology*; D009765:Obesity / Q000503:physiopathology*; D012018:Reflex; D013564:Sympathetic Nervous System / Q000503:physiopathology*