Antinociceptive effect of somatostatin microinjected into caudate putamen.
The effects of somatostatin microinjected bilaterally and unilaterally (left or right) at a dose of 10, 50 and 100 ng into the caudate putamen of male Wistar rats on nociception (analgesy-meter test) were studied. Somatostatin injected into caudate putamen resulted in analgesia. Bilateral microinjections of somatostatin significantly increased the pain threshold in a dose-dependent manner, i.e. somatostatin exerted antinociceptive effect. The pain threshold after left-side microinjections was significantly higher than that after injections into right-side. These findings suggest antinociceptive and asymmetric effects of somatostatin on pain in the caudate putamen.
Tashev
R
R
Laboratory of Experimental Psychopharmacology, Institute of Physiology, Bulgarian Academy of Sciences, Acad. G. Bonchev St., bl. 23, 1113 Sofia, Bulgaria.
Belcheva
S
S
Milenov
K
K
Belcheva
I
I
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010146:Pain / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000008:administration & dosage* / Q000494:pharmacology*
D000700:Analgesics; D013004:Somatostatin