title: Influence of hemostatic factors on spontaneous abortion.
abstract: To assess the relationship between hemostatic factors and spontaneous abortion, 134 pregnant women presenting to the emergency department were recruited and followed through 22 weeks' gestation. Cases were women experiencing a spontaneous abortion and controls were women who maintained their pregnancy. Fibrinogen, factor VII antigen, activated protein C-sensitivity ratio (APC-SR), protein S, and plasmin-antiplasmin (PAP) were measured. Cases had lower mean levels of fibrinogen and factor VII antigen compared with controls (3.1 g/L vs. 3.7 g/L and 89% of normal vs. 109% of normal, respectively). Regression analyses found that women with fibrinogen levels below 3.0 g/L had a five-fold increased risk of spontaneous abortion (OR = 5.1, 95% CI: 1.8-14.4) and women with factor VII antigen levels below 94% of normal had a threefold increased risk of spontaneous abortion normal (OR = 3.3, 95% CI: 1.2-8.5). Similar mean levels of APC-SR, protein S, and PAP were found in the two groups.
authors.affiliation: Center for Clinical Epidemiology and Biostatistics, Graduate School of Public Health, University of Pittsburgh, Pennsylvania 19104-6021, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Nelson
authors.forename: R B
authors.initials: RB
authors.lastname: Ness
authors.forename: J A
authors.initials: JA
authors.lastname: Grisso
authors.forename: M
authors.initials: M
authors.lastname: Cushman
mesh_terms: D000022:Abortion, Spontaneous / Q000097:blood* / Q000209:etiology*; D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D005260:Female; D006490:Hemostatics / Q000097:blood*; D006801:Humans; D011247:Pregnancy
chemical_list: D006490:Hemostatics