title: Hepatic response to sepsis: interaction between coagulation and inflammatory processes.
abstract: OBJECTIVE
  a) To review the hepatic response to sepsis and to establish how this response contributes to coagulation and inflammatory processes; b) to review the physiologic and biochemical mechanisms that suggest hepatic dysfunction may occur during sepsis, enhance procoagulant and proinflammatory activities, and participate in the potential evolution to multiple organ dysfunction syndrome.
  
  
  METHODS
  A summary of published medical literature from MEDLINE search files and published reviews on liver function in experimental and human sepsis.
  
  
  METHODS
  In sepsis, the liver plays a major role in host defense mechanisms. Kupffer cells are responsible for bacterial scavenging, bacterial products inactivation, and inflammatory mediators clearance and production. Hepatocytes, via receptors for many proinflammatory cytokines, modify their metabolic pathway toward gluconeogenesis, amino-acid uptake, and increased synthesis of coagulant and complement factors and protease inhibitors. The acute-phase protein (APP) response also contributes to the procoagulant state, especially by enhancing the inhibition of protein C (alpha1-antitrypsin and alpha2-macroglobulin) and by decreasing liver synthesis of protein C and antithrombin (negative APPs). Elevated C-reactive protein levels (positive APPs) promote the expression of tissue factor by mononuclear cells. Increased liver production of thrombin-activatable fibrinolytic inhibitor (positive APPs) enhances fibrinolysis inhibition. Conversely, such hepatic inflammatory and coagulation processes in sepsis may alter the function of this organ. Indeed, the liver can be injured by activated Kupffer cells that release chemokines, attract blood neutrophils into the liver, and activate them. Neutrophils up-regulate their surface adhesion molecules, tissue factor, and Kupffer cells, whereas tissue factor pathway inhibitor and thrombomodulin are almost undetectable in endothelial cells. This may lead to microcirculatory disturbances, fibrin deposition, hepatocyte injury, endotoxin and bacteria spillover, and multiple organ failure.
  
  
  CONCLUSIONS
  In sepsis, the liver participates in host defense and tissue repair through hepatic cell cross-talk that controls most of the coagulation and inflammatory processes. When this control is not adequate, a secondary hepatic dysfunction may occur and may sometimes lead to bacterial products spillover, enhanced procoagulant and inflammatory processes, and in turn, multiple organ failure and death.
authors.affiliation: Medical Intensive Care Unit, Cochin Port-Royal University-Hospital, AP-HP, Paris V University, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Dhainaut
authors.forename: N
authors.initials: N
authors.lastname: Marin
authors.forename: A
authors.initials: A
authors.lastname: Mignon
authors.forename: C
authors.initials: C
authors.lastname: Vinsonneau
mesh_terms: D000209:Acute-Phase Proteins / Q000276:immunology; D000818:Animals; D001778:Blood Coagulation Disorders / Q000276:immunology* / Q000382:microbiology*; D016207:Cytokines / Q000276:immunology; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation; D007728:Kupffer Cells / Q000276:immunology; D008099:Liver / Q000276:immunology*; D008107:Liver Diseases / Q000276:immunology* / Q000382:microbiology*; D009102:Multiple Organ Failure / Q000382:microbiology; D009504:Neutrophils / Q000276:immunology; D011486:Protein C / Q000276:immunology; D018805:Sepsis / Q000097:blood / Q000150:complications* / Q000276:immunology*
chemical_list: D000209:Acute-Phase Proteins; D016207:Cytokines; D011486:Protein C