Alteration of A549 carcinoma cell protein synthesis profile induced by lung cancer patient serum.
Several elements such as circulating DNA and metastatic cells, containing the same primary tumor mutations, oncogenic proteins, cytokines, and other tumor related not yet identified factors, can be found in the blood stream of cancer patients. In this study we have shown that serum factors presented in lung cancer patients can modify the protein profile of the lung adenocarcinoma cell line (A549). This alteration in cellular protein profile can be an important event in the cell phenotype modification necessary for the advance of the disease. There have been no similar studies regarding cancer cell protein synthesis induction by human cancer serum.
Machado Paschoal
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Laboratório de Oncologia Molecular, Serviço de Pneumologia, Hospital Universitário Clementino Fraga Filho, Brasil.
Da Glória Da Costa Carvalho
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D000230:Adenocarcinoma; D000328:Adult; D000368:Aged; D018287:Carcinoma, Large Cell / Q000097:blood / Q000378:metabolism*; D018288:Carcinoma, Small Cell / Q000097:blood / Q000378:metabolism*; D002294:Carcinoma, Squamous Cell / Q000097:blood / Q000378:metabolism*; D002465:Cell Movement; D003720:Densitometry; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000378:metabolism*; D008715:Methionine; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D013462:Sulfur Radioisotopes; D014407:Tumor Cells, Cultured
D009363:Neoplasm Proteins; D013462:Sulfur Radioisotopes; D008715:Methionine