On relationship inference using gamete identity by descent data.
Related individuals are identical by descent (IBD) at a genetic locus if they share the same DNA material from a common ancestor. Continuous gamete IBD data consist of the lengths of (in order) IBD and non-IBD regions along the genomes for gametes segregating from two related individuals and can be used to distinguish different relationships. Under the assumption that the crossovers follow a Poisson process, we show that the exact calculation of the likelihood of a particular relationship for a given gamete IBD datum is tractable. Greatgrandparent--greatgrandchild and cousin relationships are used as examples to illustrate our methods.
Zhao
H
H
Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, CT 06520-8034, USA. hongyu.zhao@yale.edu
Liang
F
F
D003198:Computer Simulation; D005260:Female; D005854:Germ Cells / Q000502:physiology*; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D009035:Mothers; D010334:Paternity; D010375:Pedigree; D016012:Poisson Distribution