Detection of malignant thymoma in primary tumor and metastatic lesions using 99mTc-tetrofosmin scintigraphy.
99mTc-tetrofosmin was developed as a myocardial perfusion imaging agent and can also be used to depict tumors. We have experienced five cases of malignant thymoma delineated on 99mTc-tetrofosmin SPECT. In one case significant activity was clearly detected in the primary tumor and metastatic lesions. In quantitative analysis, similar 99mTc-tetrofosmin and 201Tl-chloride uptake ratios were obtained (1.95+/-0.57 versus 2.27+/-0.85, respectively; n.s.). The ability of 99mTc-tetrofosmin to detect malignant thymoma was comparable to that of 201Tl-chloride. Therefore, 99mTc-tetrofosmin might be a useful tracer for the detection of malignant thymoma, although more studies will be required to evaluate its diagnostic accuracy.
Hashimoto
T
T
Department of Radiology, Dokkyo University School of Medicine, Tochigi, Japan.
Takahashi
K
K
Goto
M
M
Endo
H
H
Kono
T
T
Nishiyama
H
H
Iimura
F
F
Kuwashima
S
S
Sawada
H
H
Saiki
N
N
Yamato
M
M
Fujioka
M
M
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D006801:Humans; D008207:Lymphatic Metastasis / Q000000981:diagnostic imaging; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary; D008875:Middle Aged; D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D010997:Pleural Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D013945:Thymoma / Q000000981:diagnostic imaging* / Q000473:pathology*; D013953:Thymus Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology*
D009943:Organophosphorus Compounds; D015609:Organotechnetium Compounds; D019275:Radiopharmaceuticals; C078700:technetium tc-99m tetrofosmin