Studies on the hepatocyte protective activity and the structure-activity relationships of quinic acid and caffeic acid derivatives from the flower buds of Lonicera bournei.
13 quinic acid derivatives along with caffeic acid, methyl caffeate, myo-inositol, bis[5-formylfurfuryl] ether and 6,7-dihydroxycoumarin were isolated from the ethanol extract of the flower buds of Lonicera bournei Hemsl., among which 8 compounds were firstly obtained from this genus. The effects of different solvent soluble fractions of the ethanol extract and the pure compounds on heptocyte death induced by D-galactosamine (D-GalN)/tumor necrosis factor alpha (TNF-alpha) were studied, and the structure-activity relationships were also discussed.
Xiang
T
T
Department of Natural Medicine, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.
Xiong
Q B
QB
Ketut
A I
AI
Tezuka
Y
Y
Nagaoka
T
T
Wu
L J
LJ
Kadota
S
S
D000818:Animals; D017209:Apoptosis; D002109:Caffeic Acids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects*; D004365:Drugs, Chinese Herbal; D004987:Ethers / Q000302:isolation & purification* / Q000494:pharmacology; D005688:Galactosamine / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D022781:Hepatocytes / Q000187:drug effects*; D066298:In Vitro Techniques; D007294:Inositol / Q000494:pharmacology; D008099:Liver / Q000166:cytology* / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008516:Medicine, Chinese Traditional; D051379:Mice; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011801:Quinic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology; D014468:Umbelliferones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D002109:Caffeic Acids; D004365:Drugs, Chinese Herbal; D004987:Ethers; D006027:Glycosides; D014409:Tumor Necrosis Factor-alpha; D014468:Umbelliferones; C431423:bis(5-formylfurfuryl)ether; D011801:Quinic Acid; D007294:Inositol; D005688:Galactosamine; C007628:esculetin