Directional migration of leukocytes: their pathological roles in inflammation and strategies for development of anti-inflammatory therapies.
Directional migration of leukocytes is indispensable to innate immunity for host defense. However, recruitment of leukocytes to a site of tissue injury also constitutes a leading cause for inflammatory responses. Mechanistically, it involves a cascade of cellular events precisely regulated by temporal and spatial presentation of a repertoire of molecules in the migrating leukocytes and their surroundings (microenvironments). Here I will summarize the emerging evidence that has shed lights on the underlying molecular mechanism for directional migration of leukocytes, which has guided the therapeutical development for innovative anti-inflammatory medicines.
Geng
J G
JG
Institute of Biochemistry and Cell Biology, Chinese Academy of Sciences, Shanghai. jggeng@sunm.shcnc.ac.cn
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002465:Cell Movement / Q000187:drug effects / Q000502:physiology*; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology* / Q000503:physiopathology; D007961:Leukocyte Migration-Inhibitory Factors / Q000037:antagonists & inhibitors / Q000276:immunology; D007962:Leukocytes / Q000166:cytology / Q000276:immunology* / Q000378:metabolism; D016328:NF-kappa B / Q000037:antagonists & inhibitors / Q000276:immunology
D000893:Anti-Inflammatory Agents; D007961:Leukocyte Migration-Inhibitory Factors; D016328:NF-kappa B; D006493:Heparin