title: Cervical dystonia is associated with a polymorphism in the dopamine (D5) receptor gene.
abstract: The objective was to assess whether polymorphisms in the dopamine receptor and transporter genes are associated with development of primary cervical dystonia. A case-control allelic association study is described of 100 patients with cervical dystonia and 100 controls using polymorphisms within D1-5 receptor and dopamine transporter genes. No significant association was found between patient and control allele frequencies for polymorphisms in genes for the D1 to 4 receptors and dopamine transporter. Significant associations, however, were found for alleles 2 and 6 of the D5 receptor microsatellite. Carriage of allele 2 was associated with cervical dystonia, whereas allele 6 was overrepresented in the control group, implying a possible protective effect. The association with allele 6 remained significant after Bonferroni correction. In conclusion, the finding of a significant association with an allele in the D5 receptor gene in patients with cervical dystonia may indicate a pathogenic role of this gene (or neighbouring genes). Further studies are required to confirm this finding and to assess whether these alleles are part of distinct haplotypes associated with other polymorphisms imparting a functional effect on the D5 receptor.
authors.affiliation: Department of Clinical Neurosciences, Royal Free and University College Medical School, Rowland Hill Street, London NW3 2PF, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Placzek
authors.forename: A
authors.initials: A
authors.lastname: Misbahuddin
authors.forename: K R
authors.initials: KR
authors.lastname: Chaudhuri
authors.forename: N W
authors.initials: NW
authors.lastname: Wood
authors.forename: K P
authors.initials: KP
authors.lastname: Bhatia
authors.forename: T T
authors.initials: TT
authors.lastname: Warner
mesh_terms: D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000235:genetics*; D004247:DNA / Q000235:genetics; D050483:Dopamine Plasma Membrane Transport Proteins; D004421:Dystonia / Q000235:genetics*; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009334:Neck Muscles; D009419:Nerve Tissue Proteins; D011110:Polymorphism, Genetic / Q000235:genetics*; D017447:Receptors, Dopamine D1 / Q000235:genetics*; D050641:Receptors, Dopamine D5
chemical_list: D002352:Carrier Proteins; C493605:DRD5 protein, human; D050483:Dopamine Plasma Membrane Transport Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D017447:Receptors, Dopamine D1; D050641:Receptors, Dopamine D5; D004247:DNA