Immunoprecipitation of [(3)H]dihydroartemisinin translationally controlled tumor protein (TCTP) adducts from Plasmodium falciparum-infected erythrocytes by using anti-TCTP antibodies.
Artemisinin and its derivatives are endoperoxide-containing antimalarial drugs that appear to form adducts in situ with the Plasmodium falciparum translationally controlled tumor protein (TCTP) homolog. Immunoprecipitation with antibody to recombinant TCTP suggests that adducts may form with both monomeric and dimeric TCTP.
Bhisutthibhan
J
J
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan 48109, USA.
Meshnick
S R
SR
D000818:Animals; D000913:Antibodies, Protozoan / Q000276:immunology; D000962:Antimalarials / Q000378:metabolism*; D037621:Artemisinins; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins / Q000276:immunology / Q000378:metabolism*; D004912:Erythrocytes / Q000469:parasitology*; D010963:Plasmodium falciparum / Q000502:physiology*; D011233:Precipitin Tests; D011485:Protein Binding; D015800:Protozoan Proteins / Q000378:metabolism*; D012717:Sesquiterpenes / Q000378:metabolism*; D000090324:Tumor Protein, Translationally-Controlled 1
D000913:Antibodies, Protozoan; D000962:Antimalarials; D037621:Artemisinins; D014408:Biomarkers, Tumor; D002135:Calcium-Binding Proteins; D015800:Protozoan Proteins; D012717:Sesquiterpenes; D000090324:Tumor Protein, Translationally-Controlled 1; C039060:artenimol