Autoimmune neutropenia in pregnant women causing neonatal neutropenia.
Autoimmune neutropenia (AIN) can occur during pregnancy. However, neonatal neutropenia occurring in an infant born to a mother with AIN has only rarely been documented. Recently, we have experienced two cases of AIN during pregnancy, both of which caused severe yet transient neonatal neutropenia (< 0.3 x 10(9)/l), probably as a result of transplacental maternal anti-neutrophil autoantibodies. The anti-neutrophil antibodies seemed to be against antigens other than NA1/NA2 because the autoantibodies did not bind to neutrophils of specific NA types selectively in the granulocyte indirect immunofluorescence test. Although AIN is a relatively uncommon disease, neonatal neutropenia caused by maternal AIN may not be quite as rare.
Kameoka
J
J
Department of Rheumatology and Haematology, Tohoku University School of Medicine, Sendai, Japan. jkame@gonryo.med.tohuko.ac.jp
Funato
T
T
Miura
T
T
Harigae
H
H
Saito
J
J
Yokoyama
H
H
Takahashi
S
S
Yamada
M
M
Sasaki
O
O
Imaizumi
M
M
Takata
N
N
Meguro
K
K
Sasaki
T
T
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology*; D005260:Female; D019084:Fluorescent Antibody Technique, Indirect; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007231:Infant, Newborn; D009503:Neutropenia / Q000276:immunology*; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000276:immunology*; D011261:Pregnancy Trimester, First; D011263:Pregnancy Trimester, Third
D019268:Antibodies, Antineutrophil Cytoplasmic