title: Effectiveness and kinetic behaviour of tilmicosin in the treatment of respiratory infections in sheep.
abstract: Nineteen sheep which were anorexic, pyrexic, coughing, dyspnoeic and had a nasal discharge and symptomatic thoracic sounds on auscultation, received a single subcutaneous dose of 10 mg/kg bodyweight of tilmicosin. The clinical signs were eliminated within four to six days. The kinetic profiles of the drug after a single subcutaneous injection were compared in five healthy sheep and five infected sheep. More of the drug was absorbed by the infected animals and its concentration remained higher for significantly longer. The drug was well tolerated and no local or systemic side effects were observed.
authors.affiliation: Department of Veterinary Medicine and Pharmacology, University of Messina, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Naccari
authors.forename: F
authors.initials: F
authors.lastname: Giofrè
authors.forename: M
authors.initials: M
authors.lastname: Pellegrino
authors.forename: M
authors.initials: M
authors.lastname: Calò
authors.forename: P
authors.initials: P
authors.lastname: Licata
authors.forename: S
authors.initials: S
authors.lastname: Carli
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use*; D019540:Area Under Curve; D005260:Female; D007279:Injections, Subcutaneous / Q000662:veterinary; D018942:Macrolides; D008297:Male; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects; D009297:Nasal Mucosa / Q000382:microbiology; D010325:Pasteurella / Q000187:drug effects; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*; D012756:Sheep / Q000378:metabolism*; D012757:Sheep Diseases / Q000188:drug therapy* / Q000382:microbiology; D016896:Treatment Outcome; D015645:Tylosin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000493:pharmacokinetics* / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides; C052319:tilmicosin; D015645:Tylosin