title: Inhibition of oxygen consumption by pentachlorophenol and tetrachloroguaiacol in rainbow trout (Oncorhynchus mykiss).
abstract: Rainbow trout (Oncorhynchus mykiss) were exposed for 24 h to concentrations representing 100, 50 and 25% of the 96 h-LC50 of pentachlorophenol (PCP) or tetrachloroguaiacol (TCG), and their oxygen consumption, cardiac output, heart rate and stroke volume were measured at regular intervals. Oxygen consumption either remained stable at basal levels (PCP), or increased to 130% of basal levels (TCG) when fish were exposed to the 96 h-LC50 of each chemical. However, oxygen consumption decreased to about 50-60% of basal levels when fish were exposed to concentrations of PCP or TCG representing 50 and 25% of the 96 h-LC50. This decrease in oxygen consumption did not appear to affect cardiac function since cardiac output, heart rate and stroke volume remained stable. PCP is best known for its capacity to uncouple oxidative phosphorylation and increase oxygen consumption. However, this study showed that it can also decrease oxygen consumption, and that the effects of PCP and TCG on fish metabolism are similar.
authors.affiliation: Department of Biology, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1. jb45@st-and.ac.uk
authors.forename: J C
authors.initials: JC
authors.lastname: Brodeur
authors.forename: D G
authors.initials: DG
authors.lastname: Dixon
authors.forename: R S
authors.initials: RS
authors.lastname: McKinley
mesh_terms: D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D006139:Guaiacol / Q000031:analogs & derivatives / Q000633:toxicity*; D017686:Oncorhynchus mykiss / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010416:Pentachlorophenol / Q000633:toxicity*
chemical_list: D006139:Guaiacol; D010416:Pentachlorophenol; C434652:tetrachloroguaiacol