title: Immune recognition, response, and regulation: how T lymphocytes do it.
abstract: Effective immunity to infectious agents requires the initial recognition of antigen by specific receptors, which leads to the activation of immunocytes and the elicitation of an immune response. Because T cell antigen recognition and directed responses are complex processes, they are initiated and quelled in a highly regulated manner. Our laboratory has focused on defining the molecular processes that control T cell antigen presentation and recognition. Research in this area is focused on determining the chemical nature of antigens displayed by Major histocompatibility, complex (MHC)-encoded class I molecules and the nonclassical class I-like protein CD1d. Quantitative aspects of antigen presentation and recognition are also being studied to determine how these factors control the initiation of a T cell response. Our studies provide insights into the biochemical basis of T cell antigen recognition and response as well as the molecular processes underlying the initiation and regulation of immune responses by CD1d-restricted natural T lymphocytes.
authors.affiliation: Department of Microbiology and Immunology, Vanderbilt University School of Medicine, Nashville, TN, USA. Sebastian.Joyce@mcmail.vanderbilt.edu
authors.forename: S
authors.initials: S
authors.lastname: Joyce
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000737:chemistry / Q000276:immunology* / Q000378:metabolism; D055610:Antigens, CD1d; D017920:Antiporters / Q000172:deficiency / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006183:H-2 Antigens / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D007107:Immune System / Q000166:cytology / Q000276:immunology*; D007136:Immunoglobulins / Q000172:deficiency / Q000502:physiology; D007694:Killer Cells, Natural / Q000276:immunology; D008024:Ligands; D008055:Lipids / Q000276:immunology; D008213:Lymphocyte Activation; D026901:Membrane Transport Proteins; D051379:Mice; D018345:Mice, Knockout; D018448:Models, Immunological; D008969:Molecular Sequence Data; D011487:Protein Conformation; D021381:Protein Transport; D011948:Receptors, Antigen, T-Cell / Q000276:immunology; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology
chemical_list: D018949:Antigens, CD1; D055610:Antigens, CD1d; D017920:Antiporters; C526877:CD1D protein, human; D016207:Cytokines; D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I; D007136:Immunoglobulins; D008024:Ligands; D008055:Lipids; D026901:Membrane Transport Proteins; D011948:Receptors, Antigen, T-Cell; C107762:tapasin