Indole alkaloids from the seeds of Centaurea cyanus (Asteraceae).
Preparative RP-HPLC analysis of a methanol extract of the seeds of Centaurea cyanus afforded four indole alkaloids: moschamine, cis-moschamine, centcyamine and cis-centcyamine, the latter two being new natural products. Structures of these compounds were elucidated by comprehensive spectroscopic analyses. General toxicity of the isolates was determined by Brine Shrimp Lethality bioassay.
Sarker
S D
SD
School of Pharmacy, The Robert Gordon University, Schoolhill, AB10 1FR, Scotland, Aberdeen, UK. s.sarker@rgu.ac.uk
Laird
A
A
Nahar
L
L
Kumarasamy
Y
Y
Jaspars
M
M
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D000818:Animals; D001156:Artemia / Q000187:drug effects; D019659:Asteraceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000633:toxicity; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D012639:Seeds / Q000737:chemistry; D013056:Spectrophotometry, Ultraviolet
D000470:Alkaloids; D007211:Indoles