title: Viral load increases in SJL/J mice persistently infected by Theiler's virus after inactivation of the beta(2)m gene.
abstract: We show that inactivating the beta(2)m gene increases the viral load of SJL/J mice persistently infected by Theiler's virus. Together with previous results, this shows that the characteristics of Tmevp1, a locus which controls the amount of viral RNA that persists in the central nervous system, are those of an H-2 class I gene.
authors.affiliation: Unité des Virus Lents, CNRS URA 1930, Institut Pasteur, 75724 Paris Cedex 15, France.
authors.forename: S
authors.initials: S
authors.lastname: Aubagnac
authors.forename: M
authors.initials: M
authors.lastname: Brahic
authors.forename: J F
authors.initials: JF
authors.lastname: Bureau
mesh_terms: D000818:Animals; D018188:Cardiovirus Infections / Q000235:genetics* / Q000821:virology*; D015967:Gene Expression Regulation, Viral; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D051379:Mice; D018345:Mice, Knockout; D017945:Theilovirus / Q000235:genetics*; D019562:Viral Load
chemical_list: D015395:Histocompatibility Antigens Class I