title: Ontogeny of pig discrete Peyer's patches: expression of surface antigens.
abstract: Leukocyte populations present in the discrete Peyer's patches (PP) of the pig were characterized from birth (Day 0) to day 35 after birth by immunohistochemistry and image analysis. Immediately after birth, cell membrane expression of CD2 and CD3, major histocompatibilty complex (MHC) class 11 (both SLA (swine leukocyte antigen) -DQ+ and SLA-DR+), CD21, 74-22-15 and surface immunoglobulin (sIg) were all demonstrable. Computer assisted morphometric techniques were used to confirm the significant expansion of these cell populations from birth onwards. The distribution of the cell types was not random but suggested a preferential retention of cells at specific sites. This implies a degree of organization of immunological cells within the discrete PP, enhancing the potential to mount immune responses in the most efficient manner.
authors.affiliation: National Research Center for Protozoan Diseases, Obihiro University of Agriculture and Veterinary Medicine, Hokkaido, Japan.
authors.forename: L H
authors.initials: LH
authors.lastname: Makala
authors.forename: T
authors.initials: T
authors.lastname: Kamada
authors.forename: H
authors.initials: H
authors.lastname: Nagasawa
authors.forename: I
authors.initials: I
authors.lastname: Igarashi
authors.forename: K
authors.initials: K
authors.lastname: Fujisaki
authors.forename: N
authors.initials: N
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Mikami
authors.forename: K
authors.initials: K
authors.lastname: Haverson
authors.forename: M
authors.initials: M
authors.lastname: Bailey
authors.forename: C R
authors.initials: CR
authors.lastname: Stokes
authors.forename: P W
authors.initials: PW
authors.lastname: Bland
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000954:Antigens, Surface / Q000096:biosynthesis*; D005260:Female; D007091:Image Processing, Computer-Assisted; D018928:Immunity, Mucosal; D007150:Immunohistochemistry / Q000662:veterinary; D008297:Male; D010581:Peyer's Patches / Q000033:anatomy & histology* / Q000166:cytology / Q000254:growth & development / Q000276:immunology; D017464:Receptors, Complement 3d / Q000096:biosynthesis; D013552:Swine / Q000033:anatomy & histology* / Q000254:growth & development / Q000276:immunology
chemical_list: D000954:Antigens, Surface; D017464:Receptors, Complement 3d