title: Implants in regenerated bone in a primate model.
abstract: BACKGROUND
  Earlier publications from our laboratory described the use of guided bone regeneration to fill large bone voids in the mandible created through en bloc resection in primates. The present report describes placement of implants into the regenerated bone with subsequent prostheses construction and loading.
  
  
  METHODS
  Lesions were created in the mandibles of 9 monkeys in a standardized mandibular defect of 8 x 19 mm. Reinforced expanded polytetrafluoroethylene membranes were placed in the animals and held in place with mini screws and sutures for anywhere from 1 to 12 months. No material was added to the defect. In each animal a root-form implant was placed 12 mm distal to the abutment teeth into the regenerated bone and was loaded with a prosthesis for 12 months. These implants were compared to original implants placed in the same monkeys years earlier in the same location in non-regenerated bone. Digital radiology and histomorphometry are described.
  
  
  RESULTS
  The results show that root-form implants placed in regenerated bone show the same radiological and histomorphometric characteristics as in normal bone when loaded. In addition, the percentage of bone contact with implants seen in regenerated bone versus non-regenerated bone is the same when both are loaded (65 +/- 13% SD in regenerated bone versus 59 +/- 15% SD in non-regenerated bone).
  
  
  CONCLUSIONS
  In a primate model root-form implants placed in regenerated bone and prosthetically loaded show no difference when compared to root-form implants placed in non-regenerated bone and prosthetically loaded.
authors.affiliation: Yerkes Regional Primate Research Center, Emory University, Atlanta, GA, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Fritz
authors.forename: M K
authors.initials: MK
authors.lastname: Jeffcoat
authors.forename: M
authors.initials: M
authors.lastname: Reddy
authors.forename: D
authors.initials: D
authors.lastname: Koth
authors.forename: L D
authors.initials: LD
authors.lastname: Braswell
authors.forename: J
authors.initials: J
authors.lastname: Malmquist
authors.forename: J
authors.initials: J
authors.lastname: Lemons
mesh_terms: D016301:Alveolar Bone Loss / Q000601:surgery; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology*; D001863:Bone Screws; D000044:Dental Abutments; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D017267:Dental Prosthesis Design; D019094:Dental Prosthesis, Implant-Supported; D004195:Disease Models, Animal; D005500:Follow-Up Studies; D016557:Guided Tissue Regeneration, Periodontal; D008253:Macaca mulatta; D008297:Male; D008334:Mandible / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D008336:Mandibular Diseases / Q000601:surgery; D008567:Membranes, Artificial; D016348:Osseointegration / Q000502:physiology; D011138:Polytetrafluoroethylene; D011856:Radiographic Image Enhancement; D013223:Statistics as Topic; D013382:Subtraction Technique; D013499:Surface Properties; D013536:Suture Techniques
chemical_list: D015921:Dental Implants; D008567:Membranes, Artificial; D011138:Polytetrafluoroethylene