title: The effect of preemptive and/or postoperative ibuprofen therapy for orthodontic pain.
abstract: The control of pain during orthodontic treatment is of vital interest to both clinicians and patients. Surprisingly, there has been limited research into the control of orthodontic pain, and there is no standard of care for controlling this discomfort. The purpose of this study was to compare the effectiveness of preemptive ibuprofen therapy, postoperative ibuprofen therapy, and a combination of the 2 therapies. Forty-one orthodontic patients aged 9 years 3 months to 16 years 11 months who were to undergo separator placement were enrolled in this prospective study. Patients were randomly assigned to 1 of 3 experimental conditions: (1) 400 mg ibuprofen taken orally 1 hour before separator placement and 400 mg ibuprofen taken orally 6 hours after the initial dose, (2) 400 mg ibuprofen taken orally 1 hour before separator placement and a lactose capsule taken orally 6 hours after the initial dose, or (3) a lactose capsule taken orally 1 hour before separator placement and 400 mg ibuprofen taken 6 hours after the initial placebo. The results revealed that preemptive ibuprofen therapy significantly decreased pain that was experienced 2 hours after separator placement and at bedtime. Beginning on day 2, there was a trend for patients who had taken both preemptive and postoperative ibuprofen doses to have lower pain scores compared with the other 2 groups. In conclusion, these data indicate that ibuprofen taken 60 minutes before separator placement alleviates pain at 2 hours and at bedtime after treatment. Further study with the use of additional postoperative doses is warranted.
authors.forename: M K
authors.initials: MK
authors.lastname: Bernhardt
authors.forename: K A
authors.initials: KA
authors.lastname: Southard
authors.forename: K D
authors.initials: KD
authors.lastname: Batterson
authors.forename: H L
authors.initials: HL
authors.lastname: Logan
authors.forename: K A
authors.initials: KA
authors.lastname: Baker
authors.forename: J R
authors.initials: JR
authors.lastname: Jakobsen
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000627:therapeutic use*; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000627:therapeutic use*; D002214:Capsules; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009967:Orthodontic Appliances / Q000009:adverse effects; D010146:Pain / Q000517:prevention & control*; D010147:Pain Measurement; D010919:Placebos; D011292:Premedication; D011446:Prospective Studies; D016037:Single-Blind Method; D013223:Statistics as Topic
chemical_list: D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D002214:Capsules; D010919:Placebos; D007052:Ibuprofen