title: Six3 promotes the formation of ectopic optic vesicle-like structures in mouse embryos.
abstract: A few years ago, three novel murine homeobox genes closely related to the Drosophila sine oculis (so) gene (Six1-3) were isolated and were all included in the Six/so gene family. Because of its early expression in the developing eye field, Six3 was initially thought to be the functional ortholog of the Drosophila so gene. This hypothesis was further supported by the demonstration that ectopic Six3 expression in medaka fish (Oryzias latipes) promotes the formation of ectopic lens and retina tissue. Here, we show that similar to Drosophila, where the eyeless/Pax6 gene regulates the eye-specific expression of so, Six3 expression in the murine lens placodal ectoderm is also controlled by Pax6. We also show that ectopic Six3 expression promotes the formation of ectopic optic vesicle-like structures in the hindbrain-midbrain region of developing mouse embryos.
authors.affiliation: Department of Genetics, St. Jude Children's Research Hospital, Memphis, Tennessee 38105, USA.
authors.forename: O
authors.initials: O
authors.lastname: Lagutin
authors.forename: C C
authors.initials: CC
authors.lastname: Zhu
authors.forename: Y
authors.initials: Y
authors.lastname: Furuta
authors.forename: D H
authors.initials: DH
authors.lastname: Rowitch
authors.forename: A P
authors.initials: AP
authors.lastname: McMahon
authors.forename: G
authors.initials: G
authors.lastname: Oliver
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004268:DNA-Binding Proteins / Q000235:genetics; D004475:Ectoderm / Q000378:metabolism; D005314:Embryonic and Fetal Development; D005136:Eye Proteins; D018507:Gene Expression Regulation, Developmental; D006257:Head / Q000196:embryology; D018398:Homeodomain Proteins / Q000096:biosynthesis / Q000235:genetics*; D007908:Lens, Crystalline / Q000196:embryology* / Q000378:metabolism; D051379:Mice; D008817:Mice, Mutant Strains; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000235:genetics*; D051762:PAX2 Transcription Factor; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D013997:Time Factors; D014157:Transcription Factors / Q000235:genetics; D000097607:Homeobox Protein SIX3
chemical_list: D004268:DNA-Binding Proteins; D005136:Eye Proteins; D018398:Homeodomain Proteins; D009419:Nerve Tissue Proteins; D051762:PAX2 Transcription Factor; D000071841:PAX6 Transcription Factor; D051761:Paired Box Transcription Factors; D012097:Repressor Proteins; D014157:Transcription Factors; D000097607:Homeobox Protein SIX3; C497319:Pax2 protein, mouse; C000605732:Pax6 protein, mouse