title: Localized two-dimensional shift correlated MR spectroscopy of human brain.
abstract: A two-dimensional (2D) chemical shift correlated MR spectroscopic (COSY) sequence integrated into a new volume localization technique (90 degrees -180 degrees -90 degrees ) is proposed for whole-body MR spectroscopy (MRS). Using the product operator formalism, a theoretical calculation of the volume localization as well as the coherence transfer efficiencies in 2D MRS is presented. Phantom model solutions were used to test and optimize the efficiency of the proposed sequence. A combination of different MRI transmit/receive RF coils was used: a head MRI coil and a 3" surface coil receive combined with a body coil transmit. The J cross-peaks due to N-acetyl aspartate (NAA), glutamate/glutamine (Glx), myo-inositol (mI), creatine (Cr), choline (Ch), aspartate (Asp), gamma-aminobutyrate (GABA), taurine (Tau), glutathione (GSH), threonine (Thr), and macromolecules (MM) were identified. The cross-peak intensities excited by the proposed 2D sequence were asymmetric with respect to the diagonal peaks. Localized COSY (L-COSY) spectra of cerebral prefrontal and occipital gray/white matter regions in 15 healthy controls are presented. Magn Reson Med 46:58-67, 2001.
authors.affiliation: Department of Radiological Sciences, UCLA School of Medicine, 10833 Le Conte Avenue, Los Angeles, CA 90095-1721, USA. athomas@mednet.ucla.edu
authors.forename: M A
authors.initials: MA
authors.lastname: Thomas
authors.forename: K
authors.initials: K
authors.lastname: Yue
authors.forename: N
authors.initials: N
authors.lastname: Binesh
authors.forename: P
authors.initials: P
authors.lastname: Davanzo
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: B
authors.initials: B
authors.lastname: Siegel
authors.forename: M
authors.initials: M
authors.lastname: Frye
authors.forename: J
authors.initials: J
authors.lastname: Curran
authors.forename: R
authors.initials: R
authors.lastname: Lufkin
authors.forename: P
authors.initials: P
authors.lastname: Martin
authors.forename: B
authors.initials: B
authors.lastname: Guze
mesh_terms: D000328:Adult; D001921:Brain / Q000033:anatomy & histology* / Q000378:metabolism; D001923:Brain Chemistry; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D019047:Phantoms, Imaging