[Changes in the rat cerebral cortex ultrastructure following peroral administration of manganese chloride].
The effect of 30 days treatment with MnCl(2).4H2O (50 mg/kg in doze) on neuron ultrastructure and interneuronal contacts of cerebral cortex frontoparietal area was studied in rat. The material for the research was taken on 1st (group 1) and 4th (group 2) month of the experiment. Changes in neurons and cortex synapses were less significant than those in subcortical structures. In 1st group of experimental animals neurons displayed vacuolar system hyperplasia and swelling of a part of mitochondria. Changes in synapses were heterogenous from reduction of synaptic vesicles number and mitochondria swelling to degeneration after "dark" type. Despite the fact that intoxication with MnCl(2).4H2O was over, changes in cortical neurons in group 2 were significant although no cells with signs of reorganization were observed. In neuropil of rats from group 2 reduced number of synaptic vesicles as well as reorganized endings filled with amorphous osmiophilic content were encountered more often as compared to animals from group 2.
Bikashvili
T Z
TZ
Laboratory of Ultrastructural Study of Brain, Institute of Physiology Academy of Sciences of Georgia, Tbilisi.
Shukakidze
A A
AA
Kiknadze
G I
GI
D000284:Administration, Oral; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000648:ultrastructure; D002712:Chlorides / Q000008:administration & dosage / Q000633:toxicity*; D005625:Frontal Lobe / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D017895:Manganese Compounds / Q000008:administration & dosage; D008854:Microscopy, Electron; D010296:Parietal Lobe / Q000187:drug effects / Q000648:ultrastructure; D051381:Rats
D002712:Chlorides; D017895:Manganese Compounds; C025340:manganese chloride