title: Effects of forebrain microinjection of cholecystokinin on dopamine cell firing rate.
abstract: In anesthetized rats, midbrain dopamine (DA) neuronal firing rate was differentially sensitive to focal brain microinjection of cholecystokinin peptides (CCK-4 and CCK-8) and N-methyl-D-aspartate (NMDA) into nucleus accumbens, amygdala and prefrontal cortex. Whereas changes in DA neuronal firing rate were frequently observed in response to intra-amygdalar microinjection of CCK peptides, NMDA was most effective in eliciting changes in DA neuronal activity following intra-accumbal microinjection. Thus, stimulation of amygdalar CCK receptors and accumbal excitatory amino acid receptors may participate in the afferent regulation of midbrain DA neuronal function.
authors.affiliation: Department of Pharmacology, Texas Tech University Health Sciences Center, 3601 4th Street, Lubbock, TX 79430, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Hamilton
authors.forename: F K
authors.initials: FK
authors.lastname: Weddige
authors.forename: A S
authors.initials: AS
authors.lastname: Freeman
mesh_terms: D000596:Amino Acids / Q000737:chemistry; D000679:Amygdala / Q000378:metabolism; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects; D002766:Cholecystokinin / Q000494:pharmacology*; D004298:Dopamine / Q000494:pharmacology*; D004594:Electrophysiology; D020128:Inhibitory Concentration 50; D008297:Male; D008636:Mesencephalon / Q000187:drug effects; D016202:N-Methylaspartate / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D018697:Nootropic Agents / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000187:drug effects; D010671:Phenylurea Compounds / Q000494:pharmacology; D016548:Prosencephalon / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012844:Sincalide / Q000031:analogs & derivatives / Q000494:pharmacology; D013997:Time Factors
chemical_list: C090019:8-sulfocholecystokinin octapeptide; D000596:Amino Acids; D001570:Benzodiazepinones; D018697:Nootropic Agents; D010671:Phenylurea Compounds; C090649:L 740093; D016202:N-Methylaspartate; D002766:Cholecystokinin; D012844:Sincalide; D004298:Dopamine