Tularemia epidemic in northwestern Spain: clinical description and therapeutic response.
This study describes the clinical characteristics of tularemia in Spain's first epidemic outbreak and the therapeutic response and compares the efficacy of 3 antibiotics (streptomycin, ciprofloxacin, and doxycycline). For 142 cases of tularemia, the therapeutic failure rate was 22.5%; ciprofloxacin was the antibiotic with the lowest percentage of therapeutic failures and with the fewest side effects.
Pérez-Castrillón
J L
JL
Department of Internal Medicine, Rio Hortega Hospital, University of Valladolid, Cardenal Torquemada s/n, 47010 Valladolid, Spain. CASTRV@terra.es
Bachiller-Luque
P
P
Martín-Luquero
M
M
Mena-Martín
F J
FJ
Herreros
V
V
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D000907:Antibodies, Bacterial / Q000097:blood; D004196:Disease Outbreaks; D005260:Female; D005604:Francisella tularensis / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013030:Spain / Q000453:epidemiology; D016896:Treatment Outcome; D014406:Tularemia / Q000188:drug therapy / Q000453:epidemiology* / Q000382:microbiology / Q000503:physiopathology
D000900:Anti-Bacterial Agents; D000907:Antibodies, Bacterial