title: On-off transport through a thermoresponsive hydrogel composite membrane.
abstract: A novel thermoresponsive composite membrane is described through which the permeation of molecules is dependent on the temperature of the milieu. The thermoresponsive composite membranes utilise a thermosensitive crosslinked polymeric hydrogel, which possesses a volume phase transition temperature (VPTT). The hydrogel was polymerised in situ within the pores of a sintered glass filter, through which significant permeation of molecules only occurred at temperatures above the VPTT of the hydrogel. It was found that the permeation of molecules through the thermoresponsive composite membranes could be modulated by changing the environmental temperature.
authors.affiliation: School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, UK.
authors.forename: S K
authors.initials: SK
authors.lastname: Li
authors.forename: A
authors.initials: A
authors.lastname: D'Emanuele
mesh_terms: D000180:Acrylic Resins; D004055:Differential Thermal Analysis; D006358:Hot Temperature; D020100:Hydrogels / Q000737:chemistry*; D008567:Membranes, Artificial; D008855:Microscopy, Electron, Scanning; D010539:Permeability; D020156:Salicylic Acid / Q000737:chemistry; D012710:Serum Albumin, Bovine / Q000737:chemistry; D013696:Temperature
chemical_list: D000180:Acrylic Resins; D020100:Hydrogels; D008567:Membranes, Artificial; C052970:poly-N-isopropylacrylamide; D012710:Serum Albumin, Bovine; D020156:Salicylic Acid