Pure red cell aplasia after ABO-incompatible allogeneic stem cell transplantation in severe aplastic anemia with response to steroids: a case report and literature review.
Pure red cell aplasia (PRCA) is a rare complication after ABO-incompatible allogeneic stem cell transplantation, but its mechanism is still unknown. Here we report on a patient with severe aplastic anemia who developed PRCA after HLA-identical but major ABO-mismatched peripheral blood stem cell transplantation. Erythroid engraftment was successful with primary steroid treatment. We concluded that an adequate dose of steroids can be the first line of therapy for PRCA after ABO-mismatched allogeneic stem cell transplantation.
Yang
M H
MH
Department of Medicine, Taipei Veterans General Hospital, Taiwan.
Hsu
H C
HC
D000017:ABO Blood-Group System; D000328:Adult; D000741:Anemia, Aplastic / Q000188:drug therapy / Q000628:therapy*; D001787:Blood Group Incompatibility / Q000097:blood*; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects*; D006801:Humans; D008297:Male; D012010:Red-Cell Aplasia, Pure / Q000209:etiology*; D012720:Severity of Illness Index; D013256:Steroids / Q000627:therapeutic use*
D000017:ABO Blood-Group System; D013256:Steroids