title: Reduced number of CD1a+ cells in cutaneous B-cell lymphoma.
abstract: Cutaneous B-cell lymphoma is difficult to distinguish from pseudolymphoma. The histologic pattern and monoclonal restriction (immunohistochemical analysis and molecular biology) are the criteria used for differentiating these entities. CD1a+ dendritic cells have been observed in the infiltrates of T-cell lymphoma, but the presence of these CD1a+ cells has not been compared in B-cell lymphoma and pseudolymphoma. We studied the presence of CD1a+ cells on frozen sections of 23 B-cell lymphomas, 13 pseudolymphomas, and 17 T-cell lymphomas by immunohistochemical analysis. We found abundant CD1a+ dendritic cells in only 1 (4%) of 23 B-cell lymphomas, whereas in 8 (62%) of 13 pseudolymphomas and 17 (100%) of 17 T-cell lymphomas, strong CD1a staining was present. Our study demonstrates a distinct pattern of CD1a staining in the infiltrates of B-cell lymphoma and pseudolymphoma that may be of value in the differential diagnosis of these skin disorders.
authors.affiliation: Dept of Dermatology, University of Innsbruck, Anichstr. 35, A-6020 Innsbruck, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Schmuth
authors.forename: A
authors.initials: A
authors.lastname: Sidoroff
authors.forename: B
authors.initials: B
authors.lastname: Danner
authors.forename: G
authors.initials: G
authors.lastname: Topar
authors.forename: N T
authors.initials: NT
authors.lastname: Sepp
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000938:Antigen-Presenting Cells / Q000378:metabolism / Q000473:pathology; D018949:Antigens, CD1 / Q000378:metabolism*; D002452:Cell Count; D005260:Female; D006801:Humans; D016393:Lymphoma, B-Cell / Q000378:metabolism* / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged; D019310:Pseudolymphoma / Q000378:metabolism / Q000473:pathology; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology*
chemical_list: D018949:Antigens, CD1; C419393:CD1a antigen