title: A comparative pilot study of the effects of a dentifrice containing green tea bioflavonoids, sanguinarine or triclosan on oral bacterial biofilm formation.
abstract: The aim of the present study was to evaluate the effect of a green tea bioflavonoid/zinc ascorbate-containing dentifrice (Natural Antioxidant Toothpaste) on bacterial plaque biofilm accumulation. Plaque biofilms were formed and observed on saliva-conditioned synthetic hydroxyapatite disks (HA) over 4 days. Two test treatments were performed daily over a 4-day experimental period for a total of 8 treatments. Four test dentifrices were evaluated: a 0.1% bioflavonoid/0.2% zinc ascorbate; a non-active control test dentifrice; a 0.075% sanguinarine/2.0% zinc chloride dentifrice; and a 0.3% triclosan dentifrice. The repeated treatment of the HA with the green tea bioflavonoid/zinc ascorbate, the sanguinarine/zinc chloride, or the triclosan dentifrice resulted in significant reductions in total viable plaque biomass when compared to a non-active placebo control dentifrice.
authors.affiliation: Division of Oral Biology and Medicine, UCLA School of Dentistry, Los Angeles, CA, USA. wolinsky@ucla.edu
authors.forename: L E
authors.initials: LE
authors.lastname: Wolinsky
authors.forename: J
authors.initials: J
authors.lastname: Cuomo
authors.forename: K
authors.initials: K
authors.lastname: Quesada
authors.forename: T
authors.initials: T
authors.lastname: Bato
authors.forename: P M
authors.initials: PM
authors.lastname: Camargo
mesh_terms: D000470:Alkaloids / Q000494:pharmacology / Q000627:therapeutic use; D000704:Analysis of Variance; D000975:Antioxidants / Q000494:pharmacology / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D053119:Benzophenanthridines; D018441:Biofilms / Q000187:drug effects*; D045424:Complex Mixtures; D003773:Dental Plaque / Q000517:prevention & control*; D003802:Dentifrices / Q000494:pharmacology / Q000627:therapeutic use*; D017886:Durapatite; D005419:Flavonoids / Q000494:pharmacology / Q000627:therapeutic use*; D005459:Fluorides; D007546:Isoquinolines; D008855:Microscopy, Electron, Scanning; D008517:Phytotherapy; D010865:Pilot Projects; D012824:Silicic Acid; D019533:Streptococcus oralis / Q000187:drug effects; D013662:Tea / Q000627:therapeutic use; D014100:Toothpastes; D014260:Triclosan; D017967:Zinc Compounds / Q000627:therapeutic use
chemical_list: D000470:Alkaloids; D000975:Antioxidants; D053119:Benzophenanthridines; D045424:Complex Mixtures; D003802:Dentifrices; D005419:Flavonoids; D007546:Isoquinolines; D013662:Tea; D014100:Toothpastes; D017967:Zinc Compounds; C432564:green tea bioflavonoid, zinc ascorbate-containing toothpaste; C546060:hydrated silica gel-based toothpaste; D012824:Silicic Acid; D014260:Triclosan; D017886:Durapatite; C005705:sanguinarine; D001205:Ascorbic Acid; D005459:Fluorides