Photopolymerized biomaterials for application in the temporomandibular joint.
Chronic foreign body reactions have limited the successful application of alloplastic implants for treatment of temporomandibular joint (TMJ) disorders. There is a great clinical need for new materials with enhanced properties for application in the diarthrodial joint. Photopolymerizations may provide many advantages for fabricating new biomaterials for the TMJ and may address some of the notable differences between the TMJ and other articulations. Specifically, the feasibility of trans-tissue (i.e. through the skin) photopolymerizations may yield less-invasive surgical procedures. Also, novel 3-dimensional photoprocessing techniques may be used to fabricate patient-specific alloplastic devices for improved compliance and efficacy. Finally, the mild conditions necessary for photopolymerizations make the reaction ideal for encapsulating cells with the potential to create constructs for tissue engineering, which may be beneficial for disk replacement therapies.
Poshusta
A K
AK
Department of Chemical Engineering, University of Colorado, Boulder, Colo. 80309-0424, USA.
Anseth
K S
KS
D000818:Animals; D001672:Biocompatible Materials / Q000138:chemical synthesis* / Q000737:chemistry; D001698:Biomedical Engineering; D003094:Collagen / Q000138:chemical synthesis / Q000737:chemistry; D003432:Cross-Linking Reagents; D006801:Humans; D066298:In Vitro Techniques; D008422:Materials Testing; D010006:Osteoblasts / Q000166:cytology; D010777:Photochemistry; D019736:Prostheses and Implants; D051381:Rats; D013704:Temporomandibular Joint / Q000601:surgery*; D013705:Temporomandibular Joint Disorders / Q000601:surgery
D001672:Biocompatible Materials; D003432:Cross-Linking Reagents; D003094:Collagen