[Malignant melanoma of the nasal cavity. Retrospective study. The analysis of p53 and p16INK4 expression].
Five cases of malignant melanomata of the nasal cavities have been diagnosed and studied at ENT--and Anatomopathological Departments, between 1990 and 1997, the group ranging from 65 to 90 years, middle age 74.2. Paramount symptoms were epistaxis and lack of pain in all patients. Radical surgery was performed only in one case, followed by radiotherapy; the remainder were submitted to palliative treatment. We have reviewed the literature and also an immunohistochemical analysis about p53, p16INK4 and Rb oncogenes with the aim to establish its importance in these tumor's type. The whole group have showed high levels of p53 and MIB-1 and 60 percent a loss of oncogen p16 expression.
Padilla Parrado
M
M
Hospital Virgen de La Salud, Toledo.
Sáez Castillo
A I
AI
Galán Morales
J T
JT
Orradre Romeo
J L
JL
Delgado Quero
A L
AL
Sánchez Carrión
S
S
D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D019942:Genes, p16 / Q000235:genetics*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D009669:Nose Neoplasms / Q000235:genetics* / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies