title: Glycemic control reverses increases in urinary excretions of immunoglobulin G and ceruloplasmin in type 2 diabetic patients with normoalbuminuria.
abstract: To examine whether urinary excretions of plasma proteins with molecular radii of 45-55 A and different isoelectric points such as IgG (pI = 7.4) and ceruloplasmin (pI = 4.4) increase selectively in normoalbuminuric type 2 diabetic patients, urinary albumin excretion rate (AER), renal clearances of IgG, ceruloplasmin and alpha2-macroglobulin, and creatinine clearance (Ccr) were studied in timed overnight urine samples of 36 diabetic outpatients and 16 control subjects. Furthermore, to examine effect of glycemic control on these urinary protein excretions, the same analysis was performed before and after glycemic control in 17 diabetic inpatients admitted for glycemic control. Renal clearances of IgG and ceruloplasmin were significantly higher in diabetic outpatients than in the control group, whereas AER and renal clearance of alpha2-macroglobulin did not differ. Glycemic control caused significant decreases in renal clearances of IgG and ceruloplasmin, accompanied with tendency for Ccr to decrease (p = 0.055). The present results, together with our previous finding of selectively increased urinary excretions of 45-55 A sized plasma proteins in parallel with enhanced glomerular filtration rate after acute protein loading, led us to conclude that enhanced intraglomerular hydraulic pressure may cause increases in clearances of IgG and ceruloplasmin, and that this change can be reversed by strict glycemic control in normoalbuminuric diabetic patients.
authors.affiliation: Division of Geriatric Medicine, Akita University Hospital, Japan. narita@med.akita-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Narita
authors.forename: H
authors.initials: H
authors.lastname: Fujita
authors.forename: J
authors.initials: J
authors.lastname: Koshimura
authors.forename: H
authors.initials: H
authors.lastname: Meguro
authors.forename: H
authors.initials: H
authors.lastname: Kitazato
authors.forename: T
authors.initials: T
authors.lastname: Shimotomai
authors.forename: E
authors.initials: E
authors.lastname: Kagaya
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: M
authors.initials: M
authors.lastname: Murata
authors.forename: A
authors.initials: A
authors.lastname: Usami
authors.forename: S
authors.initials: S
authors.lastname: Ito
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism*; D002570:Ceruloplasmin / Q000652:urine*; D003430:Cross-Sectional Studies; D003924:Diabetes Mellitus, Type 2 / Q000652:urine*; D003928:Diabetic Nephropathies / Q000652:urine; D005260:Female; D006801:Humans; D006874:Hydrostatic Pressure; D007074:Immunoglobulin G / Q000652:urine*; D007678:Kidney Glomerulus / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D000511:alpha-Macroglobulins / Q000652:urine
chemical_list: D001786:Blood Glucose; D007074:Immunoglobulin G; D000511:alpha-Macroglobulins; D002570:Ceruloplasmin