A double blind parallel group placebo controlled comparison of sedative and mnesic effects of etifoxine and lorazepam in healthy subjects [corrected].
This paper describes the psychomotor and mnesic effects of single oral doses of etifoxine (50 and 100 mg) and lorazepam (2 mg) in healthy subjects. Forty-eight healthy subjects were included in this randomized double blind, placebo controlled parallel group study [corrected]. The effects of drugs were assessed by using a battery of subjective and objective tests that explored mood and vigilance (Visual Analog Scale), attention (Barrage test), psychomotor performance (Choice Reaction Time) and memory (digit span, immediate and delayed free recall of a word list). Whereas vigilance, psychomotor performance and free recall were significantly impaired by lorazepam, neither dosage of etifoxine (50 and 100 mg) produced such effects. These results suggest that 50 and 100 mg single dose of etifoxine do not induce amnesia and sedation as compared to lorazepam.
Micallef
J
J
Centre de Pharmacologie Clinique et d'Evaluations Thérapeutiques et Service de Pharmacologie Clinique, UMR-CNRS-FRE-Université de la Méditerranée, Développement et Pathologie du Mouvement, Hôpital de la Timone, 13385 Marseille cedex 5, France.
Soubrouillard
C
C
Guet
F
F
Le Guern
M E
ME
Alquier
C
C
Bruguerolle
B
B
Blin
O
O
D000293:Adolescent; D000328:Adult; D000339:Affect / Q000187:drug effects; D020324:Amnesia, Anterograde / Q000139:chemically induced*; D001288:Attention / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008140:Lorazepam / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D008568:Memory / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D010078:Oxazines / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D014149:Tranquilizing Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
D006993:Hypnotics and Sedatives; D010078:Oxazines; D014149:Tranquilizing Agents; D008140:Lorazepam; C002125:etifoxine