title: Assessment of coronary flow velocity with transthoracic Doppler echocardiography during dobutamine stress echocardiography.
abstract: OBJECTIVE
  The purpose of this study was to evaluate the feasibility of measuring coronary flow velocity (CFV) by transthoracic Doppler echocardiography (TTDE) in the left anterior descending coronary artery (LAD) during contrast-enhanced dobutamine stress echocardiography (DSE). We also assessed the value of TTDE for detecting stress-induced myocardial ischemia in the LAD territory.
  
  
  BACKGROUND
  Noninvasive assessment of both CFV and wall motion during DSE would enhance the diagnostic accuracy of DSE.
  
  
  METHODS
  One hundred forty-four consecutive patients underwent CFV recording in the distal LAD by TTDE during contrast-enhanced DSE. Regional wall motion score index (WMSI) in the LAD territory and CFV ratio at peak stress (CFV ratio peak), defined as a ratio of CFV at peak stress to basal CFV, were obtained.
  
  
  RESULTS
  Coronary flow velocity was successfully recorded in 129 patients (90%) at baseline and during dobutamine infusion. Mean value of CFV ratio peak was 2.39 +/- 0.83 (range: 0.84 to 4.40). There was good correlation between WMSI at peak stress and CFV ratio peak (r = 0.62, p < 0.001). Coronary flow velocity ratio peak was significantly lower in patients who developed stress-induced wall motion abnormality (WMA) in the LAD territory than it was in those patients without WMA (1.51 +/- 0.51 vs. 2.76 +/- 0.65, p < 0.001). A CFV ratio peak <2.1 had a sensitivity of 92% and a specificity of 86% for detecting the presence of stress-induced WMA.
  
  
  CONCLUSIONS
  Assessment of CFV in the distal LAD during DSE is feasible in the majority of cases and provides a CFV ratio for detecting stress-induced myocardial ischemia in the LAD territory.
authors.affiliation: Department of Internal Medicine, Tane General Hospital, Osaka, Japan. takeuchi@hotmail.com
authors.forename: M
authors.initials: M
authors.lastname: Takeuchi
authors.forename: C
authors.initials: C
authors.lastname: Miyazaki
authors.forename: H
authors.initials: H
authors.lastname: Yoshitani
authors.forename: S
authors.initials: S
authors.lastname: Otani
authors.forename: K
authors.initials: K
authors.lastname: Sakamoto
authors.forename: J
authors.initials: J
authors.lastname: Yoshikawa
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D002316:Cardiotonic Agents; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000503:physiopathology*; D004280:Dobutamine; D015150:Echocardiography, Doppler; D005240:Feasibility Studies; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007089:Image Enhancement; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D002316:Cardiotonic Agents; D004280:Dobutamine