title: Carboxymethyldextran-A2-Gd-DOTA enhancement patterns in the abdomen and pelvis in an animal model.
abstract: The aim of this study was to assess MR signal enhancement patterns of carboxymethyldextran (CMD)-A2-Gd-DOTA, a new macromolecular contrast agent, in the abdomen and pelvis of New Zealand white rabbits. Nine New Zealand white rabbits underwent MRI before and following injection of 0.05 mmol/kg body weight (bw) CMD-A2-Gd-DOTA (52.1 kDa), using turbo FLASH-, dynamic FLASH 60 degrees-, T1- and T2-weighted spin-echo and turbo spin-echo sequences up to 10 days p.i. Changes in blood and tissue signal intensities (deltaSI) and relaxation rates (deltaR1) were calculated. Differences between pre- and post-contrast MRI data were compared using the Scheffé test. CMD-A2-Gd-DOTA demonstrated significant blood-pool enhancement and significant tissue enhancement on T1-weighted images, whereas no significant signal changes were observed on T2-weighted images (P < 0.05). Kidney parenchyma, pelvis and bladder demonstrated a subsequent enhancement, resembling renal elimination of the majority of the contrast agent. Liver parenchyma demonstrated a slow, delayed decay of the contrast enhancement due to storage and biodegradation of larger subfractions of the contrast agent. All tissue signal intensities were back to baseline 10 days p.i. CMD-A2-Gd-DOTA is a new macromolecular contrast agent with blood-pool effect, significant signal enhancement of abdominal organs and pelvic bone marrow, partial storage in the liver and baseline tissue signal intensities by 10 days p.i.
authors.affiliation: Department of Radiology, Technical University of Munich, Germany. daldrup@roe.med.tu-muenchen.de
authors.forename: H E
authors.initials: HE
authors.lastname: Daldrup-Link
authors.forename: T M
authors.initials: TM
authors.lastname: Link
authors.forename: H E
authors.initials: HE
authors.lastname: Möller
authors.forename: D
authors.initials: D
authors.lastname: Wiedermann
authors.forename: B
authors.initials: B
authors.lastname: Bonnemain
authors.forename: C
authors.initials: C
authors.lastname: Corot
authors.forename: E J
authors.initials: EJ
authors.lastname: Rummeny
mesh_terms: D000005:Abdomen / Q000033:anatomy & histology*; D000704:Analysis of Variance; D000818:Animals; D003287:Contrast Media; D007089:Image Enhancement / Q000379:methods*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D023421:Models, Animal; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D010388:Pelvis / Q000033:anatomy & histology*; D011817:Rabbits
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C107329:carboxymethyl-dextran-A2-gadolinium-DOTA