[Synthesis of 1-hydroxyalkyl-3-substituted ureas and thioureas as a substrates for alcohol dehydrogenase].
A series of 1-(2-hydroxyethyl)- and 1-(3-hydroxyethyl)-3-substituted ureas and thioureas were synthesized. 1-(3-Hydroxyethyl)-3-acylthioureas were shown to be specific substrates for alcohol dehydrogenase in vitro.
Leonov
O N
ON
Institute of Biological Medicine, ul. Akademika Oparina 4, Mascow, 117815 Russia.
Shcherbakov
V M
VM
Devichenskiĭ
V M
VM
Kriukova
L Iu
LIu
Vorontsov
E A
EA
Kuznetsov
S L
SL
Kriukov
L N
LN
D000426:Alcohol Dehydrogenase / Q000737:chemistry*; D013379:Substrate Specificity; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000737:chemistry*; D014508:Urea / Q000138:chemical synthesis* / Q000737:chemistry*
D014508:Urea; D000426:Alcohol Dehydrogenase; D013890:Thiourea