[Mechanisms of long-term synaptic depression in the hippocampus].
Long-term depression (LTD) was studied in hippocampal slices obtained from neonatal rats at the synapses between CA3 and CA1 pyramidal neurons. The induction of the LTD required pairing of Ca2+ influx into the postsynaptic CA1 neuron through voltage-gated Ca2+ channels with activation of metabotropic glutamate receptors. The expression of this form of LTD is at least partly presynaptic, suggesting the need for a retrograde messenger. We present evidence that arachidonic acid might serve such a function. Thus applications of arachidonic acid simulate LTD whereas blockade of arachiidonic acid release inhibits LTD.
Bol'shakov
V Iu
VIu
Department of Psychiatry, MacLean Hospital, Harvard Medical School, Boston, USA.
D000818:Animals; D000831:Animals, Newborn; D016718:Arachidonic Acid / Q000494:pharmacology / Q000502:physiology; D002118:Calcium / Q000502:physiology; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D006624:Hippocampus / Q000502:physiology*; D066298:In Vitro Techniques; D018408:Patch-Clamp Techniques; D051381:Rats; D017207:Rats, Sprague-Dawley; D018094:Receptors, Metabotropic Glutamate / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission
D018690:Excitatory Amino Acid Agonists; D018094:Receptors, Metabotropic Glutamate; D016718:Arachidonic Acid; D002118:Calcium