[Mutations of genes affecting heart development of Drosophila].
Recent studies suggest that the basic molecular control mechanisms of early heart development are remarkably conserved in Drosophila, vertebrate and human being. Drosophila can be used as a prototype to explore the genetic basis of cardiogenesis in human being. Here, mutations of genes affecting heart development of Drosophila are produced by chemical mutagen methanesulfonicaeid ethyl. With staining of antibody expressed in heart precussor cells of Drosophila, 112 lethal lines were observed to show mutant phenotypes in pericardial cells. Of them, 32 lines differ in their mutant phenotypes from those of known genes. Analysis of cytogenetic mapping shows that they are located in 13 chromosomal regions without known heart-related genes, which implies that these loci contain genes probably involved in the heart development.
Li
D L
DL
College of Life Sciences, Hunan Normal University, Changsha 410081, China.
Dai
Q
Q
Yuan
W Z
WZ
Wu
X S
XS
Li
M
M
D000818:Animals; D002874:Chromosome Mapping; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D005260:Female; D006321:Heart / Q000196:embryology*; D008297:Male; D009154:Mutation