title: Intensive home-based exercise training in cardiac rehabilitation increases exercise capacity and heart rate variability.
abstract: BACKGROUND
  Reduced heart rate variability (HRV) is a risk factor for cardiac death. Animal studies have shown increased HRV and reduced mortality after physical training. We evaluated the change in exercise capacity and HRV in cardiac rehabilitation patients, randomised to routine or home-based intensive training. The design was prospective, stratified randomisation with pre-specified subgroup analysis.
  
  
  METHODS
  Maximal bicycle exercise test and 24-h Holter were performed 1 (baseline), 4 and 12 months after myocardial infarction (MI) or coronary artery by-pass surgery (CABG). Patients were randomised to physical training either two (N) or six (I) times per week for 3 months Sixty-two patients (43 MI and 19 CABG patients) were evaluated.
  
  
  RESULTS
  Exercise capacity increased significantly more after 3 months of training in group I (mean (S.E.)); 29.0 (3.4) vs. 7.2 (2.6) watts, P<0.001). One year later the difference in exercise capacity remained (26.5 (3.3) vs. 11.8 (3.8) watts, P<0.001). Global HRV measurements SDNN and SDANN increased significantly more in group I after training (17.1 (5.6) vs. 1.7 (3.7) and 16.2 (4.9) vs. 2.8 (3.1) ms, P<0.05) and 1 year later the differences were still significant. Subgroup analysis showed more pronounced HRV response in CABG than MI patients.
  
  
  CONCLUSIONS
  Intensive exercise training in cardiac rehabilitation increases exercise capacity and global HRV, which could be of prognostic significance.
authors.affiliation: Department of Medicine, Borås County Hospital, S-501 82 Borås, Sweden. hans.tygesen@telia.com
authors.forename: H
authors.initials: H
authors.lastname: Tygesen
authors.forename: C
authors.initials: C
authors.lastname: Wettervik
authors.forename: B
authors.initials: B
authors.lastname: Wennerblom
mesh_terms: D001026:Coronary Artery Bypass / Q000534:rehabilitation*; D015444:Exercise; D017079:Exercise Tolerance; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000534:rehabilitation*; D011446:Prospective Studies; D018709:Statistics, Nonparametric