title: Endoscopic evaluation of the gastrotolerance of short-term antalgic treatment with low dose k-diclofenac: a comparison of ibuprofen and aspirin.
abstract: In a short-term gastro-duodenal endoscopic study in 12 healthy volunteers, the gastrotoxicity was not different after intake of diclofenac-K 12.5 mg (0.33) or ibuprofen 200 mg (0.42, P=0.66) but significantly higher after aspirin 500 mg (2.67, P=0.002).
authors.affiliation: Unité de Recherches Thérapeutiques, Hôpital Lariboisière, 2 rue Ambroise Paré, 75010 Paris, France.
authors.forename: I
authors.initials: I
authors.lastname: Mahé
authors.forename: S
authors.initials: S
authors.lastname: Mouly
authors.forename: E
authors.initials: E
authors.lastname: Mahé
authors.forename: M
authors.initials: M
authors.lastname: Diemer
authors.forename: A L
authors.initials: AL
authors.lastname: Knellwolf
authors.forename: G
authors.initials: G
authors.lastname: Simoneau
authors.forename: C
authors.initials: C
authors.lastname: Caulin
authors.forename: J F
authors.initials: JF
authors.lastname: Bergmann
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001241:Aspirin / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004008:Diclofenac / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004386:Duodenum / Q000187:drug effects; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D010146:Pain / Q000188:drug therapy; D016037:Single-Blind Method; D013270:Stomach / Q000187:drug effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac; D001241:Aspirin; D007052:Ibuprofen