[Disturbances of rhythm and atrio-ventricular conduction in digitalis overdose. Case reports].
Three cases of patients with symptoms of digitalis overdosage were presented. The principal manifestations included complex supraventricular dysrhythmias and atrio-ventricular conduction disturbances. In the discussion a special attention was paid to digitalis dosage. Multiple factors influencing plasma concentration of digitalis including pharmacokinetics, bioavailability and drug interactions with glycosides were described. Short review of toxic manifestations of digitalis was made and the treatment of digitalis intoxication was outlined.
Janion
M
M
Wojewódzki Szpital Zespolony, Oddział Kardiologii Kielce, ul. Grunwaldzka 45.
Bakowski
D
D
Brzyźkiewicz
H
H
D000368:Aged; D000369:Aged, 80 and over; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001283:Atrioventricular Node / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology; D004070:Digitalis / Q000506:poisoning*; D004071:Digitalis Glycosides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D004347:Drug Interactions; D062787:Drug Overdose; D004359:Drug Therapy, Combination; D005260:Female; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D008297:Male; D008520:Medigoxin / Q000494:pharmacology; D008875:Middle Aged; D010431:Pentoxifylline / Q000494:pharmacology; D010946:Plants, Medicinal; D010947:Plants, Toxic; D013617:Tachycardia, Supraventricular / Q000139:chemically induced
D004071:Digitalis Glycosides; D002216:Captopril; D008520:Medigoxin; D010431:Pentoxifylline