[Adult celiac disease].
Celiac disease is much common than previously thought with a prevalence of 1/300, but most of cases are poorly symptomatic or silent. Fewer of half of patients report diarrhoea as a presenting symptom. In adults, the diagnosis should be considered, in case of isolated iron deficiency anaemia, neurological symptoms (ataxia, epilepsy), osteoporosis and arthralgia, infertility, dermatitis herpetiformis and abnormalities in liver tests. Characteristic histological features are total or subtotal villous atrophy associated with an increased number of intraepithelial lymphocytes. The most sensitive and specific circulating antibodies for the diagnosis are endomysial and transglutaminase IgA antibodies. The treatment of celiac disease requires a strict gluten free diet, but the observance to this diet is often difficult. In patients refractory to a strict gluten free diet, serious complications such as intestinal lymphoma or refractory sprue should be considered.
Cellier
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C
Service d'hépato-gastroentérologie Hôpital Européen Georges-Pompidou 75908 Paris. christophe.cellier@egp.ap-hop-paris.fr
Grosdidier
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E
D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000209:etiology; D002446:Celiac Disease / Q000175:diagnosis / Q000473:pathology / Q000628:therapy; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000209:etiology; D004035:Diet Therapy; D005983:Glutens; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D009422:Nervous System Diseases / Q000209:etiology; D010024:Osteoporosis / Q000209:etiology; D015995:Prevalence
D007070:Immunoglobulin A; D005983:Glutens