title: [The neuropathology of neonatal period: analysis of 1616 autopsies].
abstract: The lesions of the central nervous system represent an important cause of morbid-mortality in the neonatal period. This is due to the vulnerability of the brain to several adverse conditions during gestation and after birth. This study analyses the prevalence and pattern of central nervous system lesions in neonates autopsied at Hospital de Clínicas - Curitiba. There were 5743 pediatric autopsies performed in the Sector of Anatomic Pathology from 1960 to 1995 with 2049 cases corresponding to death during neonatal period. These later autopsies were reviewed and all cases with central nervous system lesions were selected and classified according to sex, age and pattern of central nervous system lesion. The central nervous system was affected in 1616 (78,87%) of neonatal autopsies and there was predominance of intracerebral hemorrhages (73,39%), congenital malformations (4,27%) and infections (3,59%). The hypoxic hemorrhages are the most prevalent central nervous system lesions in the neonatal period, affecting mainly premature babies. There was predominance of central nervous system malformations in the female neonates.
authors.affiliation: Unidade de Patologia Pediátrica e Perinatal, Serviço de Anatomia Patológica, Departamento de Patologia Médica, Hospital de Clínicas, Universidade Federal do Paraná, Curitiba, PR, Brasil. luno@uol.com.br
authors.lastname: Noronha Ld
authors.forename: F
authors.initials: F
authors.lastname: Medeiros
authors.forename: V D
authors.initials: VD
authors.lastname: Martins
authors.forename: R B
authors.initials: RB
authors.lastname: Nones
authors.forename: R P
authors.initials: RP
authors.lastname: Sepulcri
authors.forename: L M
authors.initials: LM
authors.lastname: Prevedello
authors.forename: G A
authors.initials: GA
authors.lastname: Sampaio
authors.forename: M J
authors.initials: MJ
authors.lastname: Serapião
authors.forename: L F
authors.initials: LF
authors.lastname: Torres
mesh_terms: D017677:Age Distribution; D001344:Autopsy; D002493:Central Nervous System Diseases / Q000151:congenital / Q000453:epidemiology* / Q000473:pathology; D002494:Central Nervous System Infections / Q000453:epidemiology / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D020300:Intracranial Hemorrhages / Q000453:epidemiology / Q000473:pathology; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D017678:Sex Distribution