Identification and comparison of eleven rhesus macaque chemokine receptors.
Both simian and human immunodeficiency viruses (SIV and HIV) utilize chemokine receptors, with or without CD4, as portals for entry into susceptible cells. In this report, we present the cloning and comparison of 11 rhesus macaque chemokine receptors and receptor-like proteins (CCR1, CCR2b, CCR3, CCR5, CCR8, CXCR4, STRL33, GPR1, GPR15, APJ, and CRAM-A/B), the human counterparts of which have been previously shown to be utilized by SIV for entry.
Margulies
B J
BJ
Retrovirus Biology Laboratory, Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21287, USA.
Hauer
D A
DA
Clements
J E
JE
D000595:Amino Acid Sequence; D000818:Animals; D008253:Macaca mulatta / Q000276:immunology*; D008969:Molecular Sequence Data; D019707:Receptors, Chemokine / Q000737:chemistry / Q000145:classification*; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D015302:Simian Immunodeficiency Virus / Q000737:chemistry / Q000145:classification*
D019707:Receptors, Chemokine