title: The essence of excitation.
abstract: The amino acid glutamate is the major excitatory neurotransmitter in a range of organisms from Caenorhabditis elegans to mammals, and it mediates the information processing that underlies essentially all behavior. Recent advances in our understanding of glutamate storage and release now illuminate how this ubiquitous amino acid can function as a signalling molecule.
authors.affiliation: Departments of Neurology and Physiology, Graduate Programs in Neuroscience, Cell Biology and Biomedical Sciences, University of California, San Francisco, School of Medicine, 513 Parnassus Avenue, 94143-0435, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Reimer
authors.forename: R T
authors.initials: RT
authors.lastname: Fremeau
authors.forename: E E
authors.initials: EE
authors.lastname: Bellocchio
authors.forename: R H
authors.initials: RH
authors.lastname: Edwards
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000378:metabolism; D027322:Amino Acid Transport System X-AG; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D018118:Chloride Channels / Q000378:metabolism; D018698:Glutamic Acid / Q000502:physiology*; D008954:Models, Biological; D009474:Neurons / Q000378:metabolism*; D017494:Proton Pumps / Q000378:metabolism; D015398:Signal Transduction; D050608:Sodium-Phosphate Cotransporter Proteins; D027981:Symporters; D013572:Synaptic Vesicles / Q000378:metabolism
chemical_list: D018528:ATP-Binding Cassette Transporters; D027322:Amino Acid Transport System X-AG; D002352:Carrier Proteins; D018118:Chloride Channels; D017494:Proton Pumps; D050608:Sodium-Phosphate Cotransporter Proteins; D027981:Symporters; D018698:Glutamic Acid