Levels of nerve growth factor in cerebrospinal fluid of chronic daily headache patients.
Nerve growth factor (NGF) levels were determined in the CSF of patients with chronic daily headache (CDH) and correlated with levels of sensory neuropeptides. Patients with CDH showed higher NGF levels in the CSF compared with control subjects (p < 0.0001). Higher CSF levels of substance P (SP) (p < 0.002) and calcitonin-gene-related peptide (CGRP) (p < 0.0001) were also found. There was a significant positive correlation between NGF and both SP and CGRP values. These findings suggest that NGF is involved in the long-lasting sensitization and sustained activation of the trigeminal system in CDH.
Sarchielli
P
P
Department of Neuroscience, University of Perugia, Italy.
Alberti
A
A
Floridi
A
A
Gallai
V
V
D000328:Adult; D015740:Calcitonin Gene-Related Peptide / Q000134:cerebrospinal fluid; D002908:Chronic Disease; D002940:Circadian Rhythm; D005260:Female; D006261:Headache / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D020932:Nerve Growth Factor / Q000134:cerebrospinal fluid*; D012016:Reference Values; D013373:Substance P / Q000134:cerebrospinal fluid
D013373:Substance P; D020932:Nerve Growth Factor; D015740:Calcitonin Gene-Related Peptide