title: Chiral separations of transition metal complexes using capillary zone electrophoresis.
abstract: Several buffer additives that may facilitate chiral separation for optically active transition metal (TM) systems are investigated using capillary zone electrophoresis. The TM complexes evaluated exhibit considerable heterogeneity with respect to total complex charge (0 to 4+), ligand type, and identity of the central metal including Ru2+, Ni2+, Cr3+, and Co3+, threo-D[+]-Isocitrate, potassium antimonyl-d-tartrate and dibenzoyl-L-tartrate are identified as the most efficient chiral selectors. Interestingly, TM complexes exhibiting a (3+) total complex charge exhibit a reversal of enantiomer elution order versus all other complexes when separated using the tartrate additives. Operating parameters including pH, temperature, and capillary length are discussed, and chiral separations of complex mixtures are demonstrated.
authors.affiliation: Department of Chemistry, Furman University, Greenville, SC 29613-1120, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Harris
authors.forename: N
authors.initials: N
authors.lastname: Desai
authors.forename: K E
authors.initials: KE
authors.lastname: Seaver
authors.forename: R T
authors.initials: RT
authors.lastname: Watson
authors.forename: N A
authors.initials: NA
authors.lastname: Kane-Maguire
authors.forename: J F
authors.initials: JF
authors.lastname: Wheeler
mesh_terms: D019075:Electrophoresis, Capillary / Q000379:methods*; D006863:Hydrogen-Ion Concentration; D008670:Metals / Q000302:isolation & purification*; D013237:Stereoisomerism; D013696:Temperature
chemical_list: D008670:Metals