title: Transient paralysis of the bladder due to wound botulism.
abstract: In the last 10 years, wound botulism has increasingly been reported and nearly all of these new cases have occurred in injecting-drug abusers. After absorption into the bloodstream, botulinum toxin binds irreversibly to the presynaptic nerve endings, where it inhibits the release of acetylcholine. Diplopia, blurred vision, dysarthria, dysphagia, respiratory failure and paresis of the limbs are common symptoms of this intoxication. Surprisingly and despite the well-known blocking action of the botulinum toxin on the autonomic nerve system, little attention has been paid to changes in the lower urinary tract following acute botulinum toxin poisoning. Here we report a case of bladder paralysis following wound botulism. Early diagnosis and adequate management of bladder paralysis following botulism is mandatory to avoid urologic complications. Accordingly, the prognosis is usually favorable and the bladder recovery complete.
authors.affiliation: Clinic of Urology, University Hospital Zürich, Zürich, Switzerland.
authors.forename: T
authors.initials: T
authors.lastname: Sautter
authors.forename: A
authors.initials: A
authors.lastname: Herzog
authors.forename: D
authors.initials: D
authors.lastname: Hauri
authors.forename: B
authors.initials: B
authors.lastname: Schurch
mesh_terms: D001906:Botulism / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D003014:Clostridium botulinum / Q000302:isolation & purification; D006801:Humans; D008297:Male; D009498:Neurotoxins; D010243:Paralysis / Q000175:diagnosis / Q000209:etiology*; D001743:Urinary Bladder / Q000294:innervation / Q000503:physiopathology*; D014946:Wound Infection / Q000150:complications* / Q000628:therapy
chemical_list: D009498:Neurotoxins