title: Multicentre analysis of patterns of DNA gains and losses in 204 neuroblastoma tumors: how many genetic subgroups are there?
abstract: METHODS
  Analysis of comparative genomic hybridization (CGH) data of 120 tumors from four different studies, and data of 84 previously unpublishied tumors, allowed delineation of at least six different genetic subsets of neuroblastomas.
  
  
  CONCLUSIONS
  A small number of tumors show no detectable imballances. A second group of tumors presents with gains and losses of whole chromosomes and is found predominantly in prognostically favorable stage 1 and 2 tumors. The remaining groups are characterized by the presence of partial chromosome imbalances, and are found mostly in stage 3, 4, and 4S tumors. The third group shows 17q gain without 11q loss, 1p loss, or MYCN amplification (MNA). The fourth group has 1p deletion or MNA, and finally, a fifth group shows 11q loss without 1p deletion or MNA, and is found mainly in stage 4 tumors. The latter group is significantly associated with losses of 3p, 4p, and 14q.
authors.affiliation: Department of Medical Genetics, Ghent University Hospital, Belgium.
authors.forename: J
authors.initials: J
authors.lastname: Vandesompele
authors.forename: F
authors.initials: F
authors.lastname: Speleman
authors.forename: N
authors.initials: N
authors.lastname: Van Roy
authors.forename: G
authors.initials: G
authors.lastname: Laureys
authors.forename: C
authors.initials: C
authors.lastname: Brinskchmidt
authors.forename: H
authors.initials: H
authors.lastname: Christiansen
authors.forename: F
authors.initials: F
authors.lastname: Lampert
authors.forename: M
authors.initials: M
authors.lastname: Lastowska
authors.forename: N
authors.initials: N
authors.lastname: Bown
authors.forename: A
authors.initials: A
authors.lastname: Pearson
authors.forename: J C
authors.initials: JC
authors.lastname: Nicholson
authors.forename: F
authors.initials: F
authors.lastname: Ross
authors.forename: V
authors.initials: V
authors.lastname: Combaret
authors.forename: O
authors.initials: O
authors.lastname: Delattre
authors.forename: B G
authors.initials: BG
authors.lastname: Feuerstein
authors.forename: D
authors.initials: D
authors.lastname: Plantaz
mesh_terms: D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002877:Chromosomes, Human / Q000235:genetics / Q000648:ultrastructure; D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D019656:Loss of Heterozygosity; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000145:classification / Q000235:genetics* / Q000401:mortality; D009693:Nucleic Acid Hybridization; D011379:Prognosis; D014314:Trisomy
chemical_list: D004273:DNA, Neoplasm