title: Malignant fibrous histiocytoma of soft tissue producing granulocyte colony-stimulating factor.
abstract: We treated a rare case of malignant fibrous histiocytoma (MFH) of soft tissue that produced granulocyte colony-stimulating factor (G-CSF). The patient, an 80-year-old woman, was admitted because of a feeling of abdominal fullness and leg edema. An elastic, hard, tender tumor was palpated in the right thigh. Histopathological examinations of the tumor revealed atypical and prominent pleomorphic spindle-shaped cells with funicular arrangement, which were compatible with the diagnosis of MFH. Prominent leukocytosis (up to 84,300/microl), a high serum G-CSF concentration (82 pg/ml) and positive immunohistochemical staining of the tumor tissue for G-CSF indicated that G-CSF was produced by the MFH.
authors.affiliation: Department of Internal Medicine, Nipponkokan Fukuyama Hospital, Fukuyama, Hiroshima.
authors.forename: E
authors.initials: E
authors.lastname: Mayumi
authors.forename: T
authors.initials: T
authors.lastname: Okuno
authors.forename: T
authors.initials: T
authors.lastname: Ogawa
authors.forename: K
authors.initials: K
authors.lastname: Kurata
authors.forename: H
authors.initials: H
authors.lastname: Ishioka
authors.forename: H
authors.initials: H
authors.lastname: Hamamoto
authors.forename: K
authors.initials: K
authors.lastname: Ishiki
authors.forename: T
authors.initials: T
authors.lastname: Maga
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
authors.forename: Y
authors.initials: Y
authors.lastname: Ogura
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D018219:Histiocytoma, Benign Fibrous / Q000378:metabolism* / Q000556:secondary; D006801:Humans; D007866:Leg; D008113:Liver Neoplasms / Q000378:metabolism* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000378:metabolism* / Q000556:secondary
chemical_list: D016179:Granulocyte Colony-Stimulating Factor