[Therapeutic efficacy during active phases of multiple sclerosis: gait analysis and comparison with the EDSS score].
Fifteen patients experiencing a flare-up of multiple sclerosis were given 1 g methylprednosolone per day for 5 days. The EDSS score and gait analysis using spatio-temporal variables were recorded for these patients on days 0, 5 and 45. Both methods evidenced significant improvement but the significance was observed between day 0 and day 5 for the EDSS and between day 5 and 45 for gait speed and between day 0 and 45 for step rate. Gait speed was correlated with the pyramidal scale but not with the other functional scales of the EDSS. These results suggest that EDSS and spatio-temporal gait analysis are different tools for the assessment of therapeutic effect. Gait analysis can provide a precise quantitative assessment of the locomotor handicap as a function of the proposed treatment.
Fauchard-Renard
C
C
Fédération des Sciences Neurologiques, Rouen.
Renard
J F
JF
Miret
N
N
Hannequin
D
D
Mihout
B
B
Weber
J
J
D000328:Adult; D005260:Female; D005684:Gait / Q000187:drug effects*; D006801:Humans; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000188:drug therapy*; D009460:Neurologic Examination / Q000187:drug effects*; D011446:Prospective Studies; D016037:Single-Blind Method; D016896:Treatment Outcome
D008775:Methylprednisolone