title: Antiretroviral-induced hepatic steatosis and lactic acidosis: case report and review of the literature.
abstract: As the prevalence of human immunodeficiency virus (HIV) infection continues to rise the clinician is encountered with a diagnostic challenge. Nonsurgical diseases such as acute colitis or enteritis can appear similar to such true surgical emergencies as abscess, perforation, or mesenteric ischemia. We report a case of fulminant hepatic failure associated with didanosine and masquerading as a surgical abdomen and compare the clinical, biologic, histologic, and ultrastructural findings with reports described previously. This entity should be kept in mind when evaluating the acute abdomen in the HIV-positive patient.
authors.affiliation: Department of Surgery, The Mount Sinai Medical Center, New York, New York 10029, USA.
authors.forename: S
authors.initials: S
authors.lastname: Ellozy
authors.forename: R
authors.initials: R
authors.lastname: Massen
authors.forename: L
authors.initials: L
authors.lastname: Chao
authors.forename: C M
authors.initials: CM
authors.lastname: Divino
mesh_terms: D000006:Abdomen, Acute / Q000175:diagnosis; D000140:Acidosis, Lactic / Q000175:diagnosis*; D000328:Adult; D019380:Anti-HIV Agents / Q000009:adverse effects*; D003937:Diagnosis, Differential; D016049:Didanosine / Q000009:adverse effects*; D005234:Fatty Liver / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D005260:Female; D015658:HIV Infections / Q000188:drug therapy*; D006801:Humans; D008099:Liver / Q000473:pathology; D017093:Liver Failure / Q000139:chemically induced* / Q000601:surgery
chemical_list: D019380:Anti-HIV Agents; D016049:Didanosine