title: Age-related changes in the synapses of the rat's neostriatum.
abstract: By means of transmission electron microscopy, the age-related changes in axospinous (ASS) and axodendritic (ADS) synapses in the dorsal part of the rostral neostriatum in two groups of Wistar rats: young (3-month-old), and senescent (25-month-old) were examined. The changes in different parameters, characterizing the ASS and ADS: synaptic density (SD), number of synaptic vesicles (SV), number of synaptic contact zone (SCZ), and number of dendritic spines, bearing synapses (DS) were investigated morphometrically. The SD of the ASS decreased significantly during aging, but the SD of the ADS did not changed significantly. The mean area of the synaptic boutons increased significantly during aging in two types of synapses. The mean number of vesicles per synaptic bouton increased, but the number of vesicles per microm2 of synaptic bouton, and per microm3 of the neuropil decreased. The mean SCZ length increased in both types of synapses. The total SCZ length per 1000 microm2 of the neuropil, and the total area of the SCZ per 1000 microm3 of the neuropil decreased in ASS, but the same parameters of the ADS did not changed significantly. The mean number of synaptic DS per 1000 microm2 of the neropil decreased during aging, but the mean area of the synaptic DS increased. The present results support the hypothesis that the synaptic contacts change significantly during aging, and the ASS are more vulnerable during aging than the ADS.
authors.affiliation: Institute of Physiology, Bulgarian Academy of Sciences, Sofia, Bulgaria. itzev@iph.bio.bas.bg
authors.forename: D
authors.initials: D
authors.lastname: Itzev
authors.forename: I
authors.initials: I
authors.lastname: Lolova
authors.forename: S
authors.initials: S
authors.lastname: Lolov
authors.forename: K G
authors.initials: KG
authors.lastname: Usunoff
mesh_terms: D000367:Age Factors; D000375:Aging; D000818:Animals; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D017208:Rats, Wistar; D013569:Synapses / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure