Cell cycle: how, when and why cells get rid of cyclin A.
Sequences outside the 'destruction box' direct the degradation of cyclin A to completion before the metaphase-anaphase transition; cyclin A that escapes timely degradation can block the metaphase-anaphase transition, impede anaphase and telophase, and impair a cell's ability to arrest in G1 of the next cell cycle.
Tin Su
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MCD Biology, University of Colorado, Boulder, Colorado 80309-0347, USA. tin.su@colorado.edu
D020816:Amino Acid Motifs; D000818:Animals; D002453:Cell Cycle / Q000502:physiology*; D019925:Cyclin A / Q000378:metabolism*; D006801:Humans; D008954:Models, Biological; D008941:Spindle Apparatus / Q000378:metabolism; D013997:Time Factors
D019925:Cyclin A