Structural characterization of a pentadienyl radical intermediate formed during catalysis by prostaglandin H synthase-2.
Peng
S
S
Okeley
N M
NM
Tsai
A L
AL
Wu
G
G
Kulmacz
R J
RJ
van der Donk
W A
WA
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D002384:Catalysis; D051546:Cyclooxygenase 2; D004578:Electron Spin Resonance Spectroscopy; D007527:Isoenzymes / Q000737:chemistry / Q000378:metabolism*; D008968:Molecular Conformation; D044262:Prostaglandin H2; D011451:Prostaglandin-Endoperoxide Synthases / Q000737:chemistry / Q000378:metabolism*; D011462:Prostaglandins G / Q000138:chemical synthesis / Q000737:chemistry*; D011463:Prostaglandins H / Q000096:biosynthesis / Q000737:chemistry; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007527:Isoenzymes; D011462:Prostaglandins G; D011463:Prostaglandins H; D044262:Prostaglandin H2; C038291:prostaglandin G2; D051546:Cyclooxygenase 2; D011451:Prostaglandin-Endoperoxide Synthases