[Modulation of in vivo fate of drugs: fundamental biopharmaceutical and pharmacokinetic aspects].
The in vivo fate of drugs is basically regulated by the drug's physico-chemical properties, and thus depends on its chemical structure. Three successive phases describe the fate of exogenous compounds (absorption, distribution, elimination). The first two phases can be modulated by galenic formulation. Controlling the available dose and release rate by administration route and formulation, allows to modulate bioavailability of the active substance and its delivery to the general circulation. For distribution, vectorization techniques aim at improving the benefit/risk ratio. Two approaches are used: targeting the site of action (or avoiding site(s) leading to undesirable effects) and/or specific release rates.
Devissaguet
J P
JP
Centre d'études pharmaceutiques, Université Paris XI, 5, rue Jean-Baptiste Clément, F 92296 Chetenay-Malbry Cedex.
D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D006801:Humans; D004364:Pharmaceutical Preparations / Q000737:chemistry*; D010599:Pharmacokinetics; D010600:Pharmacology
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations