Duodenogastric reflux following cholecystectomy in the dog: role of antroduodenal motor function.
BACKGROUND
Duodenogastric reflux has been implicated in the pathogenesis of gastric ulcer and gastritis. Duodenogastric reflux after cholecystectomy is also a possible cause of post-cholecystectomy syndrome.


OBJECTIVE
To investigate the role of antroduodenal motor function in increased duodenogastric reflux following cholecystectomy and the effect of trimebutine maleate (trimebutine) on the duodenogastric reflux in conscious dogs.


METHODS
Antropyloric and duodenal motility and bile acids content in the gastric juice were measured for 3 h during the inter-digestive state in dogs with or without cholecystectomy.


RESULTS
Bile acids content in the gastric juice of cholecystectomized dogs was significantly higher than that of non-cholecystectomized dogs. The frequency of pyloric relaxation during phase II of the migrating motor complex was significantly increased following cholecystectomy. Intravenous infusion of trimebutine inhibited both the increased duodenogastric reflux and the frequency of pyloric relaxation in the cholecystectomized dog.


CONCLUSIONS
Duodenogastric reflux and frequency of pyloric relaxations were increased in cholecystectomized dogs and trimebutine suppressed both of them. These findings suggest that the increased frequency of pyloric relaxation contributes to the duodenogastric reflux following cholecystectomy.
Nogi
K
K
Discovery Research Laboratory, Tanabe Seiyaku Co. Ltd, Toda, Saitama, Japan. K-nogi@tanabe.co.jp
Haruma
K
K
Taniguchi
H
H
Yomota
E
E
Okajima
M
M
Hananoki
M
M
Hata
J
J
Kusunoki
H
H
Onoda
Y
Y
D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D002763:Cholecystectomy / Q000009:adverse effects*; D004195:Disease Models, Animal; D004285:Dogs; D004383:Duodenogastric Reflux / Q000209:etiology*; D005750:Gastric Juice; D005765:Gastrointestinal Agents / Q000494:pharmacology; D005769:Gastrointestinal Motility; D007262:Infusions, Intravenous; D011706:Pyloric Antrum / Q000503:physiopathology; D014287:Trimebutine / Q000494:pharmacology
D001647:Bile Acids and Salts; D005765:Gastrointestinal Agents; D014287:Trimebutine