title: [Arachidonoylcholine and N,N-dimethylaminoethyl arachidonate are new cholinergic compounds].
abstract: Choline and N,N-dimethylaminoethyl esters of arachidonic and some other fatty acids were synthesized. Experiments on the embryos and larvae of sea urchins, sensitive to cholinergic compounds, showed that arachidonoylcholine exhibited cholinomimetic activity similar to that of nicotine whereas N,N-dimethylaminoethyl arachidonate acted as an acetylcholine antagonist. The corresponding esters of docosahexaenoic acid displayed similar biological properties.
authors.forename: V V
authors.initials: VV
authors.lastname: Bezuglov
authors.forename: G N
authors.initials: GN
authors.lastname: Zinchenko
authors.forename: L A
authors.initials: LA
authors.lastname: Nikitina
authors.forename: G A
authors.initials: GA
authors.lastname: Buznikov
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001095:Arachidonic Acids / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D018678:Cholinergic Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D012617:Sea Urchins
chemical_list: D001095:Arachidonic Acids; D018678:Cholinergic Agents; C442433:N,N-dimethylaminoethyl arachidonate; C442432:arachidonoylcholine; D016718:Arachidonic Acid