title: Microalbuminuria as a marker of preclinical diastolic dysfunction in never-treated essential hypertensives.
abstract: Using 24-h ambulatory blood pressure (BP) monitoring and digitized M-mode echocardiography, we evaluated whether microalbuminuria is related to preclinical left ventricular (LV) diastolic dysfunction in hypertensive patients. We selected 87 never-treated hypertensive patients (mean 24-h BP > 140 and/or > 90 mm Hg); albuminuria was evaluated as mean value of 24-h urinary albumin excretion (UAE) from two 24-h urine collections. Microalbuminuria was found in 28 patients, classified as MA+ (UAE 30 to 300 mg/24 h); 59 patients had normal UAE (< 30 mg/24 h) and were classified as MA-. The MA+ and MA- groups did not differ with regard to age, sex, body mass index, or 24-h heart rate, whereas 24-h, daytime, and nighttime systolic and diastolic BP were significantly higher in MA+ than in MA-. The LV mass index was greater in MA+, as was the prevalence of LV hypertrophy; peak shortening rate of LV diameter, index of systolic function, was normal in all, but was lower in MA+. Peak lengthening rate of LV diameter and peak thinning rate of posterior wall, indices of diastolic function, were lower in MA+ and the prevalence of diastolic dysfunction was higher in MA+. UAE was inversely correlated with both indices of LV diastolic function, also after correction for age, 24-h heart rate, 24-h BP, and LV mass. In conclusion, in never-treated hypertensive patients, microalbuminuria is not only associated with greater myocardial mass, but is also related with preclinical impairment of LV diastolic function. This relation, independent from increased BP or LV mass, strengthens the role of microalbuminuria as an early and reliable marker of preclinical cardiac involvement.
authors.affiliation: Department of Clinical and Biological Sciences, Faculty of Medicine, University of Insubria, Varese, Italy. amgrandi@libero.it
authors.forename: A M
authors.initials: AM
authors.lastname: Grandi
authors.forename: R
authors.initials: R
authors.lastname: Santillo
authors.forename: A
authors.initials: A
authors.lastname: Bertolini
authors.forename: D
authors.initials: D
authors.lastname: Imperiale
authors.forename: R
authors.initials: R
authors.lastname: Broggi
authors.forename: S
authors.initials: S
authors.lastname: Colombo
authors.forename: E
authors.initials: E
authors.lastname: Selva
authors.forename: A
authors.initials: A
authors.lastname: Jessula
authors.forename: L
authors.initials: L
authors.lastname: Guasti
authors.forename: A
authors.initials: A
authors.lastname: Venco
mesh_terms: D000328:Adult; D000419:Albuminuria / Q000175:diagnosis*; D015415:Biomarkers; D003971:Diastole; D005260:Female; D006801:Humans; D006973:Hypertension / Q000175:diagnosis* / Q000652:urine; D017379:Hypertrophy, Left Ventricular / Q000175:diagnosis* / Q000652:urine; D008297:Male; D008875:Middle Aged; D013599:Systole
chemical_list: D015415:Biomarkers