Catalyzed asymmetric dialkylzinc addition to benzaldehyde in the presence of new chiral ligands--delta-(1-phenethyl)aminoalcohols.
A series of delta-aminoalcohols prepared from (S)- and (R)-N,N-dimethyl-1-phenethylamines was found to catalyze the enantioselective addition of diethylzinc to benzaldehyde to yield optically active 1-phenylpropanol with enantiomeric excess 60-85%.
Demyanovich
V M
VM
Chemistry Department, Moscow State University, Leninski Gory 119899 Moscow, Russia. demyan@org.chem.msu.ru
Shishkina
I N
IN
Zefirov
N S
NS