Sesquiterpene lactones from Smyrnium olusatrum.
Fruits of Smyrnium olusatrum afforded three sesquiterpene lactones, namely, 1beta,8beta-dihydroxyeudesman-3,7(11)-dien-8alpha,12-olide, 1beta,8beta-dihydroxyeudesman-4(15),7(11)-dien-8alpha,l2-olide, and 1beta,10alpha,4alpha,5beta-diepoxy-6beta-hydroxyglechoman-8alpha,12-olide. Four related known sesquiterpenes were also isolated and characterized. The structure elucidation of the isolated compounds was based primarily on 1D and 2D NMR analyses. The in vitro cytotoxicity of the extract and isolated compounds against P-388 mouse lymphoma cells will be also discussed.
El-Gamal
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Department of Pharmacognosy, Faculty of Pharmacy, Mansoura University, 35516, Mansoura, Egypt. aelgama100@yahoo.com
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology; D002845:Chromatography; D004354:Drug Screening Assays, Antitumor; D005638:Fruit / Q000737:chemistry; D066298:In Vitro Techniques; D007783:Lactones / Q000302:isolation & purification* / Q000494:pharmacology; D008002:Libya; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D045787:Sesquiterpenes, Eudesmane; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
C436823:1,10,4,5-diepoxy-6-hydroxyglechoman-8,12-olide; C436825:1,8-dihydroxyeudesman-3,7(11)-dien-8,12-olide; C436824:1beta,8beta-dihydroxy-eudesman-4(15),7(11)-dien-8alpha,l2-olide; D000972:Antineoplastic Agents, Phytogenic; D007783:Lactones; D010936:Plant Extracts; D012717:Sesquiterpenes; D045787:Sesquiterpenes, Eudesmane