In vitro activities of MK-0826 and 16 other antimicrobials against Bacteroides fragilis group strains.
The activity of MK-0826, a new carbapenem, against 309 Bacteroides fragilis group strains was investigated and compared with that of 11 other beta-lactam and 5 non-beta-lactam agents. MK-0826 showed excellent activity (MICs ranged from < or =0.06 to 4 microg/ml). The new carbapenem may be useful in the treatment of mixed anaerobic infections involving B. fragilis group strains.
Betriu
C
C
Department of Clinical Microbiology, Hospital Clínico San Carlos, 28040 Madrid, Spain. cbetriu@efd.net
Sánchez
A
A
Palau
M L
ML
Gómez
M
M
Picazo
J J
JJ
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000302:isolation & purification; D015780:Carbapenems / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D015780:Carbapenems; C108047:L 749345