Regulation of the renal proximal tubule second sodium pump by angiotensins.
For several years it was believed that angiotensin II (Ang II) alone mediated the effects of the renin-angiotensin system. However, it has been observed that other peptides of this system, such as angiotensin-(1-7) (Ang-(1-7)), present biological activity. The effect of Ang II and Ang-(1-7) on renal sodium excretion has been associated, at least in part, with modulation of proximal tubule sodium reabsorption. In the present review, we discuss the evidence for the involvement of Na+-ATPase, called the second sodium pump, as a target for the actions of these compounds in the regulation of proximal tubule sodium reabsorption.
Caruso-Neves
C
C
Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21949-900 Rio de Janeiro RJ, Brasil.
Rangel
L B
LB
Lara
L S
LS
Lopes
A G
AG
D000803:Angiotensin I / Q000502:physiology*; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D005110:Extracellular Space / Q000201:enzymology* / Q000502:physiology; D007687:Kidney Tubules, Proximal / Q000201:enzymology*; D011945:Receptors, Angiotensin / Q000502:physiology; D012964:Sodium / Q000652:urine*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D000803:Angiotensin I; D012964:Sodium; D000254:Sodium-Potassium-Exchanging ATPase