Linker histone function in chromatin: dual mechanisms of action.
Aspects pertaining to linker histone structure and function are discussed, including the extent to which these proteins are essential, their ability to regulate specific gene expression, and recent structural data that provides a potential molecular basis for understanding how linker histones can have both repressive and stimulatory effects on genomic functions in vivo.
Georgel
P T
PT
Department of Biochemistry, University of Texas Health Science Center at San Antonio, 78229-3900, USA. georgel@uthscsa.edu
Hansen
J C
JC
D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism*; D005786:Gene Expression Regulation / Q000235:genetics; D006657:Histones / Q000737:chemistry* / Q000378:metabolism*; D009707:Nucleosomes / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D017510:Protein Folding; D017434:Protein Structure, Tertiary
D002843:Chromatin; D006657:Histones; D009707:Nucleosomes