title: Prevention of hypertrophic scars and keloids by the prophylactic use of topical silicone gel sheets following a surgical procedure in an office setting.
abstract: BACKGROUND
  Topical silicone gel sheeting has been used for more than 20 years to help reduce the size of hypertrophic scars and keloids. Its clinical efficacy and safety is well established.
  
  
  OBJECTIVE
  To determine whether topical silicone gel sheeting can be used to prevent hypertrophic scars and keloids from forming following dermatologic skin surgery.
  
  
  METHODS
  Patients undergoing skin surgery were stratified into two groups: those with no history of abnormal scarring (low-risk group) and those with a history of abnormal scarring (high-risk group). Following the procedure, patients within each group were randomized to receive either routine postoperative care or topical silicone gel sheeting (48 hours after surgery). Patients were followed for 6 months.
  
  
  RESULTS
  In the low-risk group, there were no statistical differences between individuals using routine postoperative care or using topical silicone gel sheets. In the high-risk group, there was a statistical difference (39% versus 71%) between patients who did not develop abnormal scars and used topical silicone gel sheeting and patients who developed abnormal scars after routine postoperative treatment. Those individuals having a scar revision procedure also showed a statistical difference if topical silicone gel sheeting was used following surgery.
  
  
  CONCLUSIONS
  Topical silicone gel sheeting, with a 20-year history of satisfaction in dermatology, now appears to be useful in the prevention of hypertrophic scars and keloids in patients undergoing scar revision.
authors.affiliation: Gold Skin Care Center, Nashville, Tennessee 37215, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Gold
authors.forename: T D
authors.initials: TD
authors.lastname: Foster
authors.forename: M A
authors.initials: MA
authors.lastname: Adair
authors.forename: K
authors.initials: K
authors.lastname: Burlison
authors.forename: T
authors.initials: T
authors.lastname: Lewis
mesh_terms: D000328:Adult; D000556:Ambulatory Surgical Procedures; D017439:Cicatrix, Hypertrophic / Q000209:etiology / Q000517:prevention & control*; D062109:Dermatologic Surgical Procedures; D005260:Female; D006801:Humans; D007627:Keloid / Q000209:etiology / Q000517:prevention & control*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D012307:Risk Factors; D020034:Silicone Gels / Q000008:administration & dosage*
chemical_list: D020034:Silicone Gels