Effects of Sclerocarya birrea (A. rich) hochst (anacardiaceae) leaf extracts on calcium signalling in cultured rat skeletal muscle cells.
Sclerocarya birrea is a plant used widely to treat many diseases in Burkina Faso, although no scientific data has been reported about its mechanism of action. In the present study the effects of its leaf extracts were investigated on calcium signalling in rat cultured skeletal muscle cells. The results show that the different extracts (crude decoction, aqueous, ethanolic and chloroformic extracts) have significant antagonistic effect on caffeine-induced calcium release from sarcoplasmic reticulum. Crude decoction is the most active followed by ethanolic, aqueous and chloroformic extracts in dose-dependent manner and can partly justify the use of the plant in traditional medicine.
Belemtougri
R G
RG
Faculté des Sciences et Techniques, Laboratoire de Physiologie Animale, University of Ouagadougou, Ouagadougou BP 7021, Burkina Faso.
Constantin
B
B
Cognard
C
C
Raymond
G
G
Sawadogo
L
L
D000818:Animals; D002050:Burkina Faso; D002110:Caffeine / Q000494:pharmacology; D020013:Calcium Signaling / Q000187:drug effects*; D002478:Cells, Cultured; D032462:Cycadopsida / Q000737:chemistry*; D004305:Dose-Response Relationship, Drug; D005453:Fluorescence; D016488:Medicine, African Traditional; D018482:Muscle, Skeletal / Q000166:cytology / Q000187:drug effects*; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000187:drug effects / Q000378:metabolism
D010936:Plant Extracts; D002110:Caffeine