title: Cutaneous T-cell lymphoma treated with electron beam irradiation in Indian patients.
abstract: BACKGROUND
  Cutaneous T-cell lymphoma (CTCL) is a rare occurrence in India. Total skin electron irradiation (TSEI) is a well-accepted therapeutic modality for the treatment of CTCL throughout the world. The aim of this study was to retrospectively analyze the treatment outcome of TSEI in Indian patients with CTCL and to determine the different parameters affecting the disease-free survival in these patients.
  
  
  METHODS
  Fourteen male patients between 27 and 82 years of age with CTCL (duration of disease, 4 months to 2 years) were treated with TSEI between 1985 and 1998. Seven patients had early stage disease, while the other seven had advanced disease. Two patients had lymph node involvement at the time of presentation. The TSEI was performed according to the Stanford technique delivering a total dose in the range 8-36 Gy.
  
  
  RESULTS
  Of the 14 patients, 10 showed complete remission following TSEI. The total follow-up period was 4-110 months (median, 52 months). Five patients were disease free at the end of 5 years. Two patients died due to rapid progression of the disease, while the cutaneous lesions relapsed in three patients after 2-27 months and one patient developed visceral metastasis.
  
  
  CONCLUSIONS
  TSEI was an effective therapeutic modality for the treatment of CTCL in this group of patients, both as a curative and palliative measure, although the long-term prognosis is poor.
authors.affiliation: Department of Radiation Oncology and Dermatology, All India Institute of Medical Sciences, New Delhi-110029, India.
authors.forename: D K
authors.initials: DK
authors.lastname: Parida
authors.forename: K K
authors.initials: KK
authors.lastname: Verma
authors.forename: S
authors.initials: S
authors.lastname: Chander
authors.forename: R C
authors.initials: RC
authors.lastname: Joshi
authors.forename: G K
authors.initials: GK
authors.lastname: Rath
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000505:Alopecia / Q000209:etiology; D004307:Dose-Response Relationship, Radiation; D005221:Fatigue / Q000209:etiology; D006801:Humans; D007194:India; D007958:Leukocyte Count; D016410:Lymphoma, T-Cell, Cutaneous / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D012871:Skin Diseases / Q000209:etiology; D012878:Skin Neoplasms / Q000473:pathology / Q000532:radiotherapy*