title: Clinical course of ocular Behçet's disease in siblings.
abstract: OBJECTIVE
  Familial occurrence has been reported in approximately 8% of Turkish patients with Behçet's disease. Our aim was to compare the clinical course of ocular Behçet's disease among siblings.
  
  
  METHODS
  We retrospectively studied five pairs of siblings with ocular involvement of Behçet's disease. No other family member of these siblings had any symptom of Behçet's disease.
  
  
  RESULTS
  The siblings comprised three sister-brother pairs, one sister-sister pair, and one brother-brother pair. There was a 5-10-year difference between the age at onset of ocular disease among siblings. Three of the five pairs (two sister-brother, one brother-brother) had a dissimilar course of disease activity. Female siblings had an earlier age at onset and tended to have a worse prognosis than their brothers.
  
  
  CONCLUSIONS
  It is generally acknowledged that male sex is associated with a worse prognosis. In this study, however, we observed that, among siblings with a dissimilar course, female patients were more severely affected than male patients. Poor ocular prognosis in a patient does not indicate aggressive treatment in his/her sibling. We believe that each sibling should be managed on an individual basis.
authors.affiliation: Department of Ophthalmology, Faculty of Medicine, Istanbul University, Istanbul, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Onal
authors.forename: I
authors.initials: I
authors.lastname: Tugal-Tutkun
authors.forename: M
authors.initials: M
authors.lastname: Urgancioglu
authors.forename: A
authors.initials: A
authors.lastname: Gul
mesh_terms: D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D001528:Behcet Syndrome / Q000188:drug therapy / Q000235:genetics / Q000473:pathology*; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008297:Male; D009679:Nuclear Family; D011379:Prognosis; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D005938:Glucocorticoids; D007166:Immunosuppressive Agents