Cross-linking chitosan-Fe(III), an oral phosphate binder: studies in vitro and in vivo.
The objective was to evaluate the in vitro and in vivo phosphate binding properties of cross-linked chitosan iron (III) (CH-Fe(III)-CL), a potential oral phosphate binder for treating hyperphosphatemia. At equilibrium, the in vitro phosphate binding of CH-Fe(III)-CL was 23.6 mg g(-1) for simulated gastrointestinal conditions. In hyperphosphatemic rats, CH-Fe(III)-CL was similar to iron sulfate in reducing serum phosphate by about 35%.
Bürger
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C
Núcleo de Investigações Químico-Farmacêuticas, Centro de Educação Superior em Ciências da Saúde, Universidade do Vale do Itajaí, Uruguai, 458, CP 360, 88302-202, Itajaí, SC, Brazil.
Valcarenghi
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D
Sandri
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S
Rodrigues
C A
CA
D000818:Animals; D002686:Chitin / Q000031:analogs & derivatives / Q000378:metabolism*; D048271:Chitosan; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000378:metabolism*; D008297:Male; D010710:Phosphates / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D010710:Phosphates; D002686:Chitin; D048271:Chitosan; D007501:Iron