title: [European-American-type hairy cell leukemia without splenomegaly, treated successfully with deoxycoformycin].
abstract: A 55-year-old Japanese man was hospitalized on October 5, 1999, because of high fever. Physical examination revealed neither lymphadenopathy nor hepato-splenomegaly. Laboratory data on admission showed a white blood cell count of 1,580/microliter, a hemoglobin level of 9.1 g/dl, and a platelet count of 113 x 10(3)/microliter. A small percentage of abnormal mononuclear cells were present in the peripheral blood. A bone marrow biopsy specimen demonstrated myelofibrosis and diffuse infiltration of abnormal monoculear cells with a mature B cell phenotype. A bone marrow aspirate showed 29% abnormal mononuclear cells, which had an indented or folded nucleus and reticular nuclear chromatin. Moderate to strong tartarate-resistant acid phosphatase activity was detected in these cells. Although the cytoplasmic projections were poorly preserved in specimens stained with May-Giemsa, fresh preparations showed numerous slender cytoplasmic projections by phase-contrast microscopy. The hairy cells had the phenotype CD5-, CD10-, CD11c+, CD19+, CD20+, CD25+, lambda. The patient was diagnosed as having European-American-type hairy cell leukemia (HCL) without splenomegaly, which is quite rare in Japan. The value of phase-contrast microscopy for recognition of the hairy cells was emphasized. The patient was treated successfully with deoxycoformycin (DCF).
authors.affiliation: Department of Internal Medicine, Chihaya Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Muta
authors.forename: T
authors.initials: T
authors.lastname: Okamura
authors.forename: K
authors.initials: K
authors.lastname: Oshima
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Niho
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000145:classification / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008858:Microscopy, Phase-Contrast; D008875:Middle Aged; D015649:Pentostatin / Q000627:therapeutic use*; D013163:Splenomegaly
chemical_list: D000903:Antibiotics, Antineoplastic; D015649:Pentostatin