[Synthesis of modified peptides with C-terminal alpha-amino aldehydes].
Various synthetic approaches to modified peptides with the C-terminal aldehyde group, capable of inhibiting a number of proteolytic enzymes belonging to the classes of thiol, serine, and aspartyl proteases, are considered. Both chemical methods, including solid phase peptide synthesis now widely used, and biocatalytic synthetic methods for obtaining these substances are discussed in detail.
Potetinova
Zh V
ZhV
Stepanov Laboratory of Protein Chemistry, Institute of Genetics and Selection of Industrial Microorganisms, Pervyi Dorozhnyi pr. 1, Moscow, 113545 Russia. potetinov@hotmail.com
Mil'gotina
E I
EI
Makarov
V A
VA
Voiushina
T L
TL
D000447:Aldehydes / Q000138:chemical synthesis* / Q000737:chemistry; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry; D011480:Protease Inhibitors / Q000138:chemical synthesis / Q000737:chemistry
D000447:Aldehydes; D010455:Peptides; D011480:Protease Inhibitors