title: Does reversal of ischemia on diffusion-weighted imaging reflect higher apparent diffusion coefficient values?
abstract: This study investigated whether ischemia on diffusion-weighted imaging (DWI) that reverses has higher apparent diffusion coefficients (ADCs). A patient treated with thrombolytics was evaluated with serial magnetic resonance imaging studies before treatment, at 3 and 14 days and at 4 weeks. A 100.01-cm3 left frontoparietal stroke on baseline DWI was only 18.11 cm3 (18%) on 4-week fluid attenuated inversion recovery. The mean ADC was 7.43 x 10(-3) mm2/s in the 6 regions that reversed and 7.31 x 10(-3) mm2/s in the 6 regions that persisted (P < .036). With thrombolytic treatment, large ischemic lesions on DWI may reverse, and these areas display higher mean ADCs.
authors.affiliation: Oregon Stroke Center, Oregon Health Sciences University, 3181 SW Sam Jackson Park Road, CR 131, Portland, OR 97201, USA. lutseph@ohsu.edu
authors.forename: H L
authors.initials: HL
authors.lastname: Lutsep
authors.forename: G M
authors.initials: GM
authors.lastname: Nesbit
authors.forename: R M
authors.initials: RM
authors.lastname: Berger
authors.forename: W R
authors.initials: WR
authors.lastname: Coshow
mesh_terms: D002545:Brain Ischemia / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008875:Middle Aged; D015912:Thrombolytic Therapy