Total synthesis of agosterol A: an MDR-modulator from a marine sponge.
The first total synthesis of agosterol A, a modulator of multidrug resistance (MDR) mediated by P-gp and MRP1, and isolated from a marine sponge, was achieved from ergosterol by utilizing a regioselective epoxy-cleavage reaction and regioselective dehydroxylation as the key reactions.
Murakami
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N
Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Japan.
Sugimoto
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M
Morita
M
M
Kobayashi
M
M
D000818:Animals; D018432:Drug Resistance, Multiple; D004875:Ergosterol / Q000737:chemistry; D007202:Indicators and Reagents; D011161:Porifera / Q000737:chemistry*; D013261:Sterols / Q000138:chemical synthesis*
D007202:Indicators and Reagents; D013261:Sterols; C429345:agosterol A; D004875:Ergosterol