title: [Morphometric parameters of nuclei in EBV-positive and EBV-negative Hodgkin's lymphoma].
abstract: Five morphometric parameters of nuclei of EBV-positive and EBV-negative Hodgkin's lymphoma cells were assessed for length, width, area, circumference, and circularity. For the measurement of the nuclei of the tumor cells (Hodgkin, Reed-Sternberg cells) the system of image analysis "Lucie" was used. In comparison with EBV-positive Reed-Sternberg cells, the nuclei of the EBV-negative Reed-Sternberg cells had significantly larger circumference, area and width. The nuclei of the Hodgkin cells in EBV-negative Hodgkin's lymphomas had significantly larger width and circularity. The authors assume that the altered morphometric parameters are related to a latent EBV infection.
authors.affiliation: Ustav patologie Lékarské fakulty Univerzity Palackého, Olomouc.
authors.forename: J
authors.initials: J
authors.lastname: Macák
authors.forename: P
authors.initials: P
authors.lastname: Riháková
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002467:Cell Nucleus / Q000648:ultrastructure* / Q000821:virology; D002648:Child; D002675:Child, Preschool; D020031:Epstein-Barr Virus Infections / Q000150:complications; D005260:Female; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006689:Hodgkin Disease / Q000000981:diagnostic imaging* / Q000821:virology; D006801:Humans; D008198:Lymph Nodes / Q000648:ultrastructure / Q000821:virology; D008297:Male; D008875:Middle Aged; D014463:Ultrasonography