Roux-en-Y gastric bypass for recurrent nonalcoholic steatohepatitis in liver transplant recipients with morbid obesity.
BACKGROUND
Severe obesity is common before and after liver transplantation and has been associated with significant morbidity and mortality. Furthermore, it may cause graft dysfunction through the development of recurrent nonalcoholic steatohepatitis.


METHODS
We performed Roux-en-Y gastric bypass in two morbidly obese patients who had undergone liver transplantation and had graft dysfunction secondary to recurrent nonalcoholic steatohepatitis.


RESULTS
Both patients demonstrated dramatic weight loss and had normalization of liver enzymes, lipids, and glucose levels. Repeated liver biopsy showed regression of steatosis.


CONCLUSIONS
Roux-en-Y gastric bypass can be successfully performed in liver transplant recipients with morbid obesity and may lead to weight loss, correction of metabolic abnormalities, and regression of hepatic dysfunction secondary to recurrent steatosis.
Duchini
A
A
Division of General Surgery and Organ Transplantation, Scripps Clinic and Research Foundation, 10666 N. Torrey Pines Road, La Jolla, CA 92037, USA.
Brunson
M E
ME
D000328:Adult; D000713:Anastomosis, Roux-en-Y; D005234:Fatty Liver / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D005260:Female; D015390:Gastric Bypass; D006505:Hepatitis / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008099:Liver / Q000473:pathology; D016031:Liver Transplantation; D008297:Male; D009767:Obesity, Morbid / Q000150:complications / Q000601:surgery*; D012008:Recurrence