title: Treatment of post-keratoplasty astigmatism by topography supported customized laser ablation.
abstract: OBJECTIVE
  To evaluate the clinical and optical efficiency of topography modulated customized corneal ablations for irregular corneal astigmatism.
  
  
  METHODS
  Sixteen eyes of 16 patients with iatrogenic corneal astigmatism (post keratoplasty) were consecutively included. Based on preoperative corneal topographic measurements height deviations from a spherical corneal shape were calculated and transferred to a flying-spot excimer laser. Photo-refractive keratectomy of the topographic irregularities was then performed. Clinical and optical efficiency was evaluated by best corrected visual acuity and by computation of corneal wavefront aberrations before and up to one year after treatment. Wavefront aberrations were decomposed by Zernike polynomial analysis.
  
  
  RESULTS
  Before treatment the average best-corrected visual acuity was 0.23. Three and 12 months after PRK the average best-corrected visual acuity had increased to 0.37 (p<0.05) and 0.45 (p<0.05), respectively. Corneal wavefront aberrations (root-mean-square) were 3.35 before surgery and 1.88 (p<0.05) and 1.51 (p<0.05) at three and 12 months after treatment. Zernike polynomial decomposition of the wavefront aberrations revealed that regular corneal astigmatism was the most important aberration component before and after surgery. Regular astigmatism was significantly decreased by the procedure, whereas coma, spherical aberrations, and higher-order aberrations were not reduced significantly.
  
  
  CONCLUSIONS
  Topography modulated photorefractive keratectomy of highly astigmatic corneal grafts can improve best corrected visual acuity and reduce corneal wavefront aberrations. Even in apparently irregular topographic astigmatism, regular astigmatic wavefront aberration may be the most important contributor to wavefront errors.
authors.affiliation: Department of Ophthalmology, Arhus University Hospital, Arhus, Denmark. eklfjh@aau.dk
authors.forename: J Ø
authors.initials: JØ
authors.lastname: Hjortdal
authors.forename: N
authors.initials: N
authors.lastname: Ehlers
mesh_terms: D001251:Astigmatism / Q000209:etiology / Q000601:surgery*; D003315:Cornea / Q000473:pathology / Q000601:surgery*; D019781:Corneal Topography; D006801:Humans; D007049:Iatrogenic Disease; D015948:Keratoplasty, Penetrating / Q000009:adverse effects*; D054018:Lasers, Excimer; D018903:Photorefractive Keratectomy; D014792:Visual Acuity