Asphyxia-induced release of alpha-melanocyte-stimulating hormone in newborn pigs.
Asphyxia and reperfusion induced changes in the plasma and cerebrospinal fluid (CSF) concentrations of alpha-melanocyte-stimulating hormone (alpha-MSH) were studied in newborn pigs using a specific radioimmunoassay technique. Cardiovascular and metabolic failure induced by neonatal asphyxia resulted in a 3-fold, significant (P < 0.05) increase in plasma alpha-MSH levels, whereas the hormone concentration in CSF was significantly (P < 0.05) reduced by 50% during postasphyxial reperfusion. Our data indicate an asphyxia-induced release of alpha-MSH, and suggest a discordant regulation of plasma and CSF concentrations in newborn pigs.
Kovács
J
J
Department of Pediatrics, University of Szeged, Korányi fasor 14-15., H-6720 Szeged, Hungary. kovacsjo@pedia.szote.u-szeged.hu
Julesz
J
J
Mogyoróssy
M V
MV
Deli
M A
MA
Abrahám
C S
CS
Vecsernyés
M
M
D000818:Animals; D000831:Animals, Newborn; D001237:Asphyxia; D011030:Pneumothorax; D011863:Radioimmunoassay; D015424:Reperfusion; D013552:Swine; D013997:Time Factors; D000521:alpha-MSH / Q000097:blood / Q000134:cerebrospinal fluid / Q000494:pharmacology*
D000521:alpha-MSH