title: A rational approach to the design of selective substrates and potent nontransportable inhibitors of the excitatory amino acid transporter EAAC1 (EAAT3). new glutamate and aspartate analogues as potential neuroprotective agents.
authors.forename: G
authors.initials: G
authors.lastname: Campiani
authors.forename: M
authors.initials: M
authors.lastname: De Angelis
authors.forename: S
authors.initials: S
authors.lastname: Armaroli
authors.forename: C
authors.initials: C
authors.lastname: Fattorusso
authors.forename: B
authors.initials: B
authors.lastname: Catalanotti
authors.forename: A
authors.initials: A
authors.lastname: Ramunno
authors.forename: V
authors.initials: V
authors.lastname: Nacci
authors.forename: E
authors.initials: E
authors.lastname: Novellino
authors.forename: C
authors.initials: C
authors.lastname: Grewer
authors.forename: D
authors.initials: D
authors.lastname: Ionescu
authors.forename: T
authors.initials: T
authors.lastname: Rauen
authors.forename: R
authors.initials: R
authors.lastname: Griffiths
authors.forename: C
authors.initials: C
authors.lastname: Sinclair
authors.forename: E
authors.initials: E
authors.lastname: Fumagalli
authors.forename: T
authors.initials: T
authors.lastname: Mennini
mesh_terms: D027322:Amino Acid Transport System X-AG; D000818:Animals; D001224:Aspartic Acid / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D001692:Biological Transport; D002352:Carrier Proteins / Q000737:chemistry* / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D015195:Drug Design; D050580:Excitatory Amino Acid Transporter 3; D050491:Glutamate Plasma Membrane Transport Proteins; D005971:Glutamates / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D066298:In Vitro Techniques; D008958:Models, Molecular; D008968:Molecular Conformation; D018696:Neuroprotective Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000378:metabolism; D018408:Patch-Clamp Techniques; D011869:Radioligand Assay; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013329:Structure-Activity Relationship; D027981:Symporters
chemical_list: D027322:Amino Acid Transport System X-AG; D002352:Carrier Proteins; D050580:Excitatory Amino Acid Transporter 3; D050491:Glutamate Plasma Membrane Transport Proteins; D005971:Glutamates; D018696:Neuroprotective Agents; C493398:Slc1a1 protein, rat; D027981:Symporters; D001224:Aspartic Acid; D012964:Sodium