Antibody-Based targeting of angiogenesis.
Angiogenesis-the sprouting of new blood vessels from pre-existing ones-is a characteristic feature of relevant diseases such as cancer, some blinding ocular disorders, rheumatoid arthritis, and psoriasis. This article reviews recent progress in the generation of monoclonal antibodies, which recognize and target new blood vessels in vivo, while sparing mature vessels and healthy tissues. The use of such antibodies as selective "molecular vehicles" is likely to open new important diagnostic and therapeutic opportunities.
Halin
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Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology Zürich.
Neri
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D000906:Antibodies / Q000008:administration & dosage*; D015415:Biomarkers; D016503:Drug Delivery Systems; D004730:Endothelium, Vascular / Q000166:cytology; D005109:Extracellular Matrix; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009369:Neoplasms / Q000098:blood supply / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000276:immunology* / Q000517:prevention & control* / Q000628:therapy
D000906:Antibodies; D015415:Biomarkers