title: Acute hemolysis and severe neonatal hyperbilirubinemia in glucose-6-phosphate dehydrogenase-deficient heterozygotes.
abstract: Two premature female infants had severe hyperbilirubinemia caused by hemolysis. Both neonates were heterozygotes for the glucose-6-phosphate dehydrogenase Mediterranean mutation as determined by DNA analysis. Glucose-6-phosphate dehydrogenase-deficient heterozygotes may be susceptible to the complications of this enzyme deficiency.
authors.affiliation: Department of Neonatology, Shaare Zedek Medical Center, and the Faculty of Medicine of the Hebrew University, Jerusalem, Israel.
authors.forename: M
authors.initials: M
authors.lastname: Kaplan
authors.forename: C
authors.initials: C
authors.lastname: Hammerman
authors.forename: H J
authors.initials: HJ
authors.lastname: Vreman
authors.forename: D K
authors.initials: DK
authors.lastname: Stevenson
authors.forename: E
authors.initials: E
authors.lastname: Beutler
mesh_terms: D004252:DNA Mutational Analysis; D005260:Female; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000235:genetics*; D006461:Hemolysis; D006579:Heterozygote; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000235:genetics*; D007567:Jaundice, Neonatal / Q000235:genetics*