[First advances in molecular endocrinology obtained using the Cre/LoxP system].
The insulin-like growth factor I (IGF-I) is produced in the liver and is considered mediating the effect of the growth hormone (GH). However, a knock-out only in liver IGF-I slightly disturbs the growth and development of mice. Such mice develop insulin resistance of various organs, including muscles. A knock-out in the liver insulin gene also results in insulin resistance. Selective inactivation of the gene for glucokinase (a target of insulin) in pancreatic islets or in the liver suppresses insulin secretion in the pancreas.
Pankov
Iu A
IuA
yuri-pankov@mtu-net.ru
D000818:Animals; D005941:Glucokinase / Q000037:antagonists & inhibitors; D013006:Growth Hormone / Q000502:physiology; D007333:Insulin Resistance; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis / Q000502:physiology; D019426:Integrases / Q000235:genetics / Q000502:physiology*; D051379:Mice; D018345:Mice, Knockout; D014764:Viral Proteins
D014764:Viral Proteins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D005941:Glucokinase; C045073:Cre recombinase; D019426:Integrases