title: Sporothrix schenckii thermo-intolerant mutants losing fatal visceral infectivity but retaining high cutaneous infectivity.
abstract: Four mutants of the Sporothrix schenckii lung isolate IFM 41598 were isolated by their inability to form colonies on a Sabouraud glucose agar plate incubated at 37 degrees C for 4 days. In contrast to the parent IFM 41598, these thermo-intolerant mutants were all defective in producing fatal visceral infections in mice, even though they retained infectivity in footpad tissues with a small fungal inoculum (approximately equals 10 cfu).
authors.affiliation: Department of Bacteriology Niigata University School of Medicine, Japan. toshiaki@med.niigata-u.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Tachibana
authors.forename: T
authors.initials: T
authors.lastname: Matsuyama
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: M
authors.initials: M
authors.lastname: Mitsuyama
mesh_terms: D000818:Animals; D003881:Dermatomycoses / Q000382:microbiology* / Q000503:physiopathology; D005528:Foot / Q000382:microbiology; D005800:Genes, Fungal; D006801:Humans; D008172:Lung Diseases, Fungal / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D009604:Nitrosoguanidines; D013175:Sporothrix / Q000235:genetics* / Q000472:pathogenicity*; D013174:Sporotrichosis / Q000382:microbiology* / Q000503:physiopathology; D013696:Temperature; D014774:Virulence
chemical_list: D009604:Nitrosoguanidines