title: Acquired hemophilia A in a patient with systemic lupus erythematosus.
abstract: A patient with systemic lupus erythematosus (SLE) developed acquired hemophilia A. The patient, a 24-year-old Japanese woman, was referred to our hospital because of uncontrollable bleeding following a tooth extraction. Laboratory examination revealed prolonged APTT (116 seconds), reduced factor VIII activity (2.8 %) and the presence of factor VIII inhibitor at a titer of 46.5 Bethesda units/ml. Transfusion of prothrombin complex concentrate and activated prothrombin complex concentrate followed by administration of prednisolone and cyclophosphamide successfully arrested bleeding and reduced the factor VIII inhibitor level. Acquired hemophilia A is a rare but lethal condition. Rapid diagnosis and introduction of adequate therapies are critical.
authors.affiliation: Third Department of Internal Medicine, Gunma University School of Medicine, Maebashi.
authors.forename: T
authors.initials: T
authors.lastname: Ishikawa
authors.forename: N
authors.initials: N
authors.lastname: Tsukamoto
authors.forename: M
authors.initials: M
authors.lastname: Suto
authors.forename: H
authors.initials: H
authors.lastname: Uchiumi
authors.forename: H
authors.initials: H
authors.lastname: Mitsuhashi
authors.forename: A
authors.initials: A
authors.lastname: Yokohama
authors.forename: A
authors.initials: A
authors.lastname: Maesawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nojima
authors.forename: T
authors.initials: T
authors.lastname: Naruse
mesh_terms: D000328:Adult; D005260:Female; D006467:Hemophilia A / Q000209:etiology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*