title: Uncomplicated moderate coronary artery dissections after balloon angioplasty: good outcome without stenting.
abstract: OBJECTIVE
  To study the relation between moderate coronary dissections, coronary flow velocity reserve (CFVR), and long term outcome.
  
  
  METHODS
  523 patients undergoing balloon angioplasty and sequential intracoronary Doppler measurements were examined as part of the DEBATE II trial (Doppler endpoints balloon angioplasty trial Europe). After successful balloon angioplasty, patients were randomised to stenting or no further treatment. Dissections were graded at the core laboratory by two observers and divided into four categories: none, mild (type A-B), moderate (type C), severe (types D to F). Patients with severe dissections (n = 128) or without available reference vessel CFVR (n = 139) were excluded. The remaining 256 patients were divided into two groups according to the presence (group A, n = 45) or absence (group B, n = 211) of moderate dissection.
  
  
  RESULTS
  Following balloon angioplasty, there was no difference in CFVR between the two groups. At 12 months follow up, a higher rate of major adverse cardiac events was observed overall in group A than in group B (10 (22%) v 23 (11%), p = 0.041). However, the risk of major adverse events was similar in the subgroups receiving balloon angioplasty (group A, 6 (19%) v group B, 16 (16%), NS). Among group A patients, the adverse events risk was greater in those randomised to stenting (odds ratios 6.603 v 1.197, p = 0.046), whereas there was no difference in risk if the group was analysed according to whether the CFVR was < 2.5 or >/= 2.5 after balloon angioplasty.
  
  
  CONCLUSIONS
  Moderate dissections left untreated result in no increased risk of major adverse cardiac events. Additional stenting does not improve the long term outcome.
authors.affiliation: Hartcentrum Rotterdam, University Hospital Dijkzigt-Thoraxcenter Bd 408, Dr Molewaterplein, 40-3015GD Rotterdam, Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Albertal
authors.forename: G
authors.initials: G
authors.lastname: Van Langenhove
authors.forename: E
authors.initials: E
authors.lastname: Regar
authors.forename: I P
authors.initials: IP
authors.lastname: Kay
authors.forename: D
authors.initials: D
authors.lastname: Foley
authors.forename: G
authors.initials: G
authors.lastname: Sianos
authors.forename: K
authors.initials: K
authors.lastname: Kozuma
authors.forename: T
authors.initials: T
authors.lastname: Beijsterveldt
authors.forename: S G
authors.initials: SG
authors.lastname: Carlier
authors.forename: J A
authors.initials: JA
authors.lastname: Belardi
authors.forename: E
authors.initials: E
authors.lastname: Boersma
authors.forename: J E
authors.initials: JE
authors.lastname: Sousa
authors.forename: B
authors.initials: B
authors.lastname: de Bruyne
authors.forename: P W
authors.initials: PW
authors.lastname: Serruys
mesh_terms: D000784:Aortic Dissection / Q000503:physiopathology; D015906:Angioplasty, Balloon, Coronary / Q000379:methods*; D001783:Blood Flow Velocity; D003327:Coronary Disease / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015607:Stents; D016896:Treatment Outcome; D018084:Ultrasonography, Interventional