title: A brief review of Dr F Gotoh's contribution to neuroscience: research in the field of cerebral blood flow and stroke.
abstract: Professor Emeritus Fumio Gotoh began and continues his remarkable career in medicine at Keio University. Since his graduation from medical school there in 1951, Dr. Gotoh has devoted himself to neurology, especially in the enigmatic field of stroke science. He is most renown for his groundbreaking research and leadership in the study of cerebral blood flow and metabolism. Beginning with his doctoral thesis paper in 1959 entitled "Effects of blood pressure on cerebral circulation," our article briefly delineates how Prof. Gotoh has paved the path for current and future discoveries in modern medicine. Although wholly difficult to sum up Dr. Gotoh's extensive career in such a short article, we have attempted to chronologically list and furthermore to describe his numerous works. Herein we describe his expansion to the international arena with his contributions at Wayne State University as well as his novel cerebral blood gas monitoring techniques now used in modified fashion throughout the world. From his CO2-based investigations in animals to his study of the autonomic nervous system's role in human cerebrovascular control, we remark on Dr. Gotoh's accomplishments without the use of functional imaging. Yet despite the basic science theme of his research, he has always kept them clinically correlated to entities such as Cheyne-Stokes phenomenon and Shy-Drager syndrome. Prof. Gotoh has been asked to head some of the most influential stroke societies and was the second president of the International Stroke Society. In conjunction with leading authorities, he developed a quantifiable, evidence-based stroke scale which was introduced in the International Journal of Stroke in 2001. Today despite his retirement, Dr. Gotoh continues his work in cerebral blood flow and metabolism.
authors.affiliation: Department of Neurology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Amano
mesh_terms: D002560:Cerebrovascular Circulation; D004730:Endothelium, Vascular / Q000502:physiology; D049673:History, 20th Century; D006706:Homeostasis; D007564:Japan; D009488:Neurosciences / Q000266:history*; D009569:Nitric Oxide / Q000266:history; D020521:Stroke / Q000266:history; D014481:United States
chemical_list: D009569:Nitric Oxide