title: The use of antimetabolites with trabeculectomy: a critical appraisal.
abstract: OBJECTIVE
  To examine why most ophthalmologists routinely use mitomycin C or 5-fluorouracil (antimetabolites) in association with filtering surgery for glaucoma.
  
  
  METHODS
  Critical analysis of seven medical, social and economic trends.
  
  
  RESULTS
  The rapid acceptance of the adjunctive use of antimetabolites at the time of filtration surgery may be explained by reasons other than anticipated increase in the "success" of glaucoma surgery.
  
  
  CONCLUSIONS
  The use of antimetabolites in conjuction with filtering glaucoma surgery may be at least partially a consequence of changing medical-social-economic factors, rather than solely a desire on the part of physicians to improve the "success" of glaucoma surgery. This may indicate a need to reevaluate the proper place of antimetabolites in association with filtration surgery.
authors.forename: G L
authors.initials: GL
authors.lastname: Spaeth
authors.forename: E
authors.initials: E
authors.lastname: Mutlukan
mesh_terms: D000963:Antimetabolites / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003695:Delivery of Health Care / Q000191:economics; D005472:Fluorouracil / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy* / Q000191:economics / Q000601:surgery*; D006801:Humans; D007429:Intraocular Pressure; D016685:Mitomycin / Q000627:therapeutic use*; D014130:Trabeculectomy
chemical_list: D000963:Antimetabolites; D016685:Mitomycin; D005472:Fluorouracil