[Effect of the hepatocarcinogen ortho-aminoazotoluene on induction of tyrosine-aminotransferase by glucocorticoids in mouse liver].
o-Aminoazotoluene (OAT) suppressed more than twofold the glucocorticoid induction of tyrosine aminotransferase (TAT) in the liver of SWR mice, which are sensitive to the hepatocarcinogenic effect of OAT, but not in resistant AKR mice. The hormone- and DNA-binding activities of the glucocorticoid receptor (GR) were not affected in either line. The OAT-dependent suppression proved to be associated with a decrease in the DNA-binding activity of HNF3 in liver cell extracts. The content of the HNF3 mRNA did not change, suggesting a posttranscriptional effect of OAT.
Kropachev
K Iu
KIu
Kaledin
V I
VI
Timofeeva
O A
OA
Il'nitskaia
S I
SI
Vasil'eva
E D
ED
Plisov
S Iu
SIu
Rychkova
N A
NA
Filipenko
M L
ML
Merkulova
T I
TI
D000818:Animals; D001483:Base Sequence; D002273:Carcinogens / Q000494:pharmacology*; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004790:Enzyme Induction; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced*; D008297:Male; D051379:Mice; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism; D014444:Tyrosine Transaminase / Q000096:biosynthesis*; D009762:o-Aminoazotoluene / Q000494:pharmacology*
D002273:Carcinogens; D017931:DNA Primers; D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; D014444:Tyrosine Transaminase; D009762:o-Aminoazotoluene