[Detection of viral aetiology in cerebral spinal fluid samples from 580 clinical cases].
OBJECTIVE
To investigate the viral aetiology in cerebral spinal fluid (Csf) from 580 cases of CNS infection or FUO in Yuedong district from 1990 to 1997.


METHODS
Virus isolation was done with Hep-2 and BHK-21 cells.


RESULTS
21 virus types of 5 kinds of viruses were isolated from 113 samples (19.5%). Clinically diagnosed diseases included viral encephalitis 17.8% (43/242), intracranial infection 20.2% (47/233), paralytic diseases 24.3% (9/37), FUO 37.5% (9/24), convulsion 16.0% (4/25), Guillain-Barre syndrome 5.3% (1/19). Virus infection included 11 cases of Poliovirus (constitutional ratio 0.0973, including 1 Polio-I, 8 Polio-II, 2 Polio-III); 54 cases of Coxsackie virus (0.477 9, including 11 CoxA24, 10 CoxBl, 2 Cox134, 3 CoxB5); 15 cases of ECHO virus (0.1327, including 4 ECHO-24, 3 ECRO-7, 2 ECHO-12 and each one of ECHO-3, 11,14,15,27,32); 25 cases of Enterovirus (0.2213, including 14 EV-70, 11 EV-71); 8 cases of Adenovirus (0.070 8, including 3 Adv-2, 3 Adv-3 and 2 Adv7). Results of different age groups indicated there was significant difference (P < 0.05) in virus detection rate in two age groups. Virus positive rates in different years were 1990-1991 14.2% (15/106), 1992-1993 14.1%(23/163), 1994-1995 26.1% (36/138), 1996-1997 22.5% (39/173), that showed a significant difference (P <0.05).


CONCLUSIONS
Virus infection rate of CNS diseases and FUO showed an a ascending trend, and the different virus types and kinds were isolated in different periods.
Xie
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The Second Affiliated Hospital of Medical College of Shantou University, Shantou 515041, China.
Xiang
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D000256:Adenoviridae / Q000302:isolation & purification; D000293:Adolescent; D000328:Adult; D000368:Aged; D020805:Central Nervous System Viral Diseases / Q000134:cerebrospinal fluid / Q000209:etiology*; D002555:Cerebrospinal Fluid / Q000821:virology*; D002648:Child; D002675:Child, Preschool; D004770:Enterovirus / Q000302:isolation & purification; D029822:Enterovirus B, Human / Q000302:isolation & purification; D005260:Female; D005335:Fever of Unknown Origin / Q000134:cerebrospinal fluid / Q000821:virology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D017955:Poliovirus / Q000302:isolation & purification