[The efficacy of antiviral antibiotic 17997 on treatment of HSV-1 infected guinea pig skin infection].
OBJECTIVE
To study the treatment efficacy of antiviral antibiotic 17997 against HSVl infected guinea pig skin infection.


METHODS
Guinea pig skin was infected by HSV1. 24hrs or 48hrs of post infection local treatment of 0.3% 17997 cream was started, tid for five days. In the mean time, acyclovir treatment, cream treatment and virus control were included.


RESULTS
Local treatment of 0.3% 17997 cream showed therapeutic effects, it reduced the average scores of skin lesion, accelerated crusting-time and healing-time.


CONCLUSIONS
0.3% 17997 cream showed significant treatment efficacy when compared with cream and virus controls by reducing skin lesion scores and healing-time. The treatment efficacy of 3.0% acyclovir cream was a little bit better than 0.3% 17997 cream.
Tao
P
P
Institute of Medicinal Biotechnology, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, China.
Wang
S
S
Leng
Q
Q
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000188:drug therapy*; D018259:Herpesvirus 1, Human; D008297:Male; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D000998:Antiviral Agents; D000212:Acyclovir