[A primary observation of the active immune prevention effects against dental caries using the streptococcus mutans surface protein P1 in rats].
To observe the anti-caries effects of a small dose of the surface protein antigen P1. The SD rats were immunized with P1-CTB and P1-PCG through IN (intranasal immunization) and IG (intragastric immunization). The results showed that caries was reduced heavily. There was no obvious difference between IN and IG. P1-CTB and P1-PCG can be used as an antigen to prevent the dental caries, but much further research work still need to do.
Li
F
F
College of Stomatology, West China University of Medical Sciences.
Luo
Z
Z
Zhou
X
X
D000818:Animals; D001426:Bacterial Proteins / Q000302:isolation & purification; D002772:Cholera Toxin; D003731:Dental Caries / Q000517:prevention & control*; D005260:Female; D000922:Immunotoxins / Q000627:therapeutic use*; D008297:Male; D008562:Membrane Glycoproteins; D010446:Peptide Fragments; D051381:Rats; D017207:Rats, Sprague-Dawley; D013295:Streptococcus mutans / Q000737:chemistry
D001426:Bacterial Proteins; D000922:Immunotoxins; D008562:Membrane Glycoproteins; D010446:Peptide Fragments; C055764:S-layer proteins; C050310:cholera toxin, B subunit (50-64); D002772:Cholera Toxin