title: Surgical treatment for pathological long bone fracture in patients with multiple myeloma: a retrospective analysis of 22 cases.
abstract: BACKGROUND
  The purpose of this study was to retrospectively review the cases of pathologic long bone fractures caused by multiple myeloma treated in our hospital, to analyze the surgical method, complications, radiation therapy, survival time, and influence on quality of life.
  
  
  METHODS
  In a retrospective study, 22 patients with the pathological long bone fractures due to multiple myeloma who were surgically treated between 1987 and 1997 were analyzed. All patients received open reduction and internal fixation either with plates or intra-medullary nailing. Cement augmentations were performed in the majority of cases (91%). A detailed retrospective analysis was done to correlate the surgical methods, radiation therapy, functional results, and complications post-surgically.
  
  
  RESULTS
  The most common site of fracture was the femur. The mean postoperative survival time was around 19 months. Post-operative pain relief was satisfactory, and only two patients required narcotics. No major complications were observed. However the union rate was only 30%, which might have been due to the inhibitory effect of radiation therapy on bone healing, or insufficient osteogentic ability of the myeloma-involved bone.
  
  
  CONCLUSIONS
  Satisfactory pain relief and low implant failure rate was achieved and no definite evidence of tumor dissemination was found in this study. The authors suggest that open reduction and internal fixation with cement augmentation is a favorable treatment option for those patients suitable for surgery. However, postoperative radiation therapy may be associated with a low rate of union.
authors.affiliation: Department of Orthopedic Surgery, Chang Gung Memorial Hospital, Taipei, Taiwan, R.O.C.
authors.forename: S A
authors.initials: SA
authors.lastname: Chang
authors.forename: S S
authors.initials: SS
authors.lastname: Lee
authors.forename: S W
authors.initials: SW
authors.lastname: Ueng
authors.forename: L J
authors.initials: LJ
authors.lastname: Yuan
authors.forename: C H
authors.initials: CH
authors.lastname: Shih
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D050723:Fractures, Bone / Q000532:radiotherapy / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000601:surgery*; D011183:Postoperative Complications; D012189:Retrospective Studies