title: An expeditious approach toward the total synthesis of CP-263,114.
abstract: [reaction: see text] Assembly of the carbocyclic core of CP-263,114 has been accomplished efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels-Alder sequence, tandem radical cyclization, and the late-stage fragmentation of a densely functionalized isotwistane skeleton.
authors.affiliation: Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Njardarson
authors.forename: I M
authors.initials: IM
authors.lastname: McDonald
authors.forename: D A
authors.initials: DA
authors.lastname: Spiegel
authors.forename: M
authors.initials: M
authors.lastname: Inoue
authors.forename: J L
authors.initials: JL
authors.lastname: Wood
mesh_terms: D003500:Cyclization; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008299:Maleic Anhydrides / Q000138:chemical synthesis*; D008958:Models, Molecular; D010084:Oxidation-Reduction
chemical_list: C104957:CP 263114; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D008299:Maleic Anhydrides