[Hypertension in patients with diabetes mellitus--selected pathogenetic and therapeutic aspects].
The pathogenesis of hypertension in diabetes type 1 and type 2 is different. Diabetic nephropathy is regarded as the most essential factor contributing to the development of hypertension in patients with diabetes mellitus type 1. Obesity, insulin resistance and hyperinsulinaemia are responsible for hypertension in diabetes mellitus type 2. In both types of diabetes, hypertension is involved in fast progress of diabetic renal disease. Antihypertensive treatment in diabetic patients should include: non-pharmacological interventions, drug-therapy, regular blood pressure monitoring, educational efforts. ACE-inhibitors, calcium antagonists, diuretics, beta-blockers, angiotensin II receptor antagonists and alpha 1-blockers are used as antihypertensive agents in diabetic patients. Neutral endopeptidase inhibitors are the new, promising therapeutic option.
Zukowska-Szczechowska
E
E
Katedra i Klinika Chorób Wewnetrznych i Diabetologii Slaskiej Akademii Medycznej.
Tomaszewski
M
M
Grzeszczak
W
W
D000959:Antihypertensive Agents / Q000627:therapeutic use; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D003928:Diabetic Nephropathies / Q000150:complications; D006801:Humans; D006946:Hyperinsulinism / Q000150:complications; D006973:Hypertension / Q000209:etiology* / Q000628:therapy*; D007333:Insulin Resistance; D009765:Obesity / Q000150:complications; D012307:Risk Factors
D000959:Antihypertensive Agents