Dynamic observation of pulmonary perfusion using continuous arterial spin-labeling in a pig model.
The continuous arterial spin-labeling (CASL) method of perfusion MRI is used to observe pulmonary perfusion dynamically in an animal model. Specifically, a respiratory-triggered implementation of the CASL method is used with approximate spatial resolution of 0.9 x 1.8 x 5.0 mm (0.008 cc) and 2-minute temporal resolution. Perfusion MRI is performed dynamically during repeated balloon occlusion of a segmental pulmonary artery, as well as during pharmacological stimulation. A total of three Yorkshire pigs were studied. The results demonstrate the ability of the endogenous spin-labeling method to characterize the dynamic changes in pulmonary perfusion that occur during important physiological alterations.
Roberts
D A
DA
Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-4283, USA. roberts@oasis.rad.upenn.edu
Rizi
R R
RR
Lipson
D A
DA
Ferrante
M A
MA
Bearn
L
L
Rolf
L
L
Baumgardner
J
J
Yamomoto
A
A
Hatabu
H
H
Hansen-Flaschen
J
J
Gefter
W B
WB
Schnall
M D
MD
D000818:Animals; D021721:Balloon Occlusion; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010477:Perfusion; D011651:Pulmonary Artery; D011652:Pulmonary Circulation; D013113:Spin Labels; D013552:Swine
D013113:Spin Labels