[A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs].
OBJECTIVE
To analyze the hereditary susceptibility for HLA-DQA1 alleles according to trait of multiple genes leading to disease in atherothrombotic brain infarction (ABI).


METHODS
HLA-DQA1 alleles in ABI patients (n=81) and healthy controls (n=99) were detected by PCR-SSP techniques.


RESULTS
(1)The frequency of HLA-DQA1*0301 was significantly higher in ABI patients. (2)The frequency of HLA-DQA1*0301 was significantly higher in patients with family history of essential hypertension (EH). (3)The frequency of HLA-DQA1*0103 was significantly lower in ABI patients.


CONCLUSIONS
HLA-DQA1*0301 allele might be a correlative gene with hereditary susceptibility of ABI and HLA-DQA1*0301 allele might be a correlative gene in ABI patients with the family history of essential hypertension, whereas HLA-DQA1*0103 allele might be a protective gene in the patients with ABI.
Shen
N
N
Department of Medicine, Hu Guo Si Hospital of Traditional Chinese Medicine Affliated to Beijing Traditional Chinese Medicine and Materia Medical University,Beijing 100035 P.R.China.
Yan
Z
Z
He
P
P
Jin
Y
Y
Wang
S
S
D000368:Aged; D044466:Asian People; D020520:Brain Infarction / Q000235:genetics*; D004198:Disease Susceptibility; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006683:HLA-DQ Antigens / Q000737:chemistry / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020521:Stroke / Q000235:genetics
D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen