title: Good correlation between gated single photon emission computed myocardial tomography and contrast ventriculography in the assessment of global and regional left ventricular function.
abstract: OBJECTIVE
  The purpose of this study was to determine the reliability of the measured left ventricular ejection fraction (LVEF) and wall motion analysis by the recently introduced quantitative electrocardiographically (ECG)-gated myocardial perfusion single-photon emission computed myocardial tomography technique (gated SPECT) (QGS).
  
  
  METHODS
  We compared technetium-99 m tetrofosmin gated SPECT imaging and contrast ventriculography in the assessment of global and regional left ventricular function in 74 patients with undiagnosed chest pain of whom 27 sustained a previous myocardial infarction.
  
  
  RESULTS
  Linear regression analysis demonstrated that gated SPECT determined LVEF correlated well with LVEF determined from contrast ventriculography (y = 0.95x + 1.9, r2 = 0.84, p < 0.0001). Bland-Altman plot analysis showed no systematic difference between the two sets of values derived from the two imaging approaches over a wide range of LVEF values. Exact agreement of segmental wall motion scores was 460 of 518 (89%) segments with a kappa value of 0.76 (p < 0.0001).
  
  
  CONCLUSIONS
  We conclude that gated SPECT imaging is an accurate and reliable clinical tool to accurately measure global and regional left ventricular function.
authors.affiliation: Department of Cardiology, Leiden University Medical Center, The Netherlands.
authors.forename: D E
authors.initials: DE
authors.lastname: Atsma
authors.forename: C D
authors.initials: CD
authors.lastname: Bavelaar-Croon
authors.forename: G
authors.initials: G
authors.lastname: Germano
authors.forename: P
authors.initials: P
authors.lastname: Dibbets-Schneider
authors.forename: B L
authors.initials: BL
authors.lastname: van Eck-Smit
authors.forename: E K
authors.initials: EK
authors.lastname: Pauwels
authors.forename: E E
authors.initials: EE
authors.lastname: van der Wall
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002637:Chest Pain / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D015637:Gated Blood-Pool Imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000502:physiology; D011336:Probability; D011859:Radiography; D012044:Regression Analysis; D012680:Sensitivity and Specificity; D013318:Stroke Volume; D013667:Technetium; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging*; D016277:Ventricular Function, Left / Q000502:physiology
chemical_list: D003287:Contrast Media; D013667:Technetium