title: Human herpesvirus 8 can be transmitted through blood in drug addicts.
abstract: Human Herpes virus type-8 (HHV-8) seroprevalence was studied in a population of HIV positive intravenous drug users (IVDUs) from Argentina. Analysis of this population also indirectly made it possible to study HHV-8 blood transmission, because these individuals frequently engage in needle sharing behavior and are capable of acquiring a broad array of blood borne pathogens, including Hepatitis B/C virus. The seroprevalence of HHV-8 in IVDUs was compared to a group of non-IVDUs and HIV negative individuals. Of the 223 individuals tested, 13.45% were HHV-8 positive, 16.99% in the IVDUs group, and 5.71% in the non-IVDUs. Among HIV positive IVDUs, 25/144 (17.36%) were also HHV-8 seropositive. The seropositivity rate of HHV-8 in HIV negative IVDUs was 11.1%. In contrast, HHV-8 seroprevalence in HIV negative heterosexual individuals without drug usage behavior was even lower (5.71%). The rate of HHV-8 infection in HIV positive IVDUs was three times as high compared to the non IVDU HIV negative individuals, suggesting that IVDU is a risk for HHV-8 infection. Furthermore, it was found that IVDUs showed a very high rate of Hepatitis B/C (52.77%), which also correlate with HHV-8 infection in this population (23.68%). All Hepatitis B/C positive individuals were also HIV positive. Our data confirm other studies showing that individuals who share needles are at risk for acquiring Hepatitis B/C and HIV infections. In addition, our results suggest that they are also at risk to acquiring HHV-8 infection by the same route.
authors.affiliation: University of Nebraska School of Biological Sciences, Lincoln, NE, USA.
authors.forename: C
authors.initials: C
authors.lastname: Sosa
authors.forename: J
authors.initials: J
authors.lastname: Benetucci
authors.forename: C
authors.initials: C
authors.lastname: Hanna
authors.forename: L
authors.initials: L
authors.lastname: Sieczkowski
authors.forename: G
authors.initials: G
authors.lastname: Deluchi
authors.forename: A M
authors.initials: AM
authors.lastname: Canizal
authors.forename: H
authors.initials: H
authors.lastname: Mantina
authors.forename: W
authors.initials: W
authors.lastname: Klaskala
authors.forename: M
authors.initials: M
authors.lastname: Baum
authors.forename: C
authors.initials: C
authors.lastname: Wood
mesh_terms: D000328:Adult; D001118:Argentina / Q000453:epidemiology; D016022:Case-Control Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000821:virology*; D006509:Hepatitis B / Q000175:diagnosis; D006526:Hepatitis C / Q000175:diagnosis; D006566:Herpesviridae Infections / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D019288:Herpesvirus 8, Human / Q000302:isolation & purification / Q000502:physiology*; D006801:Humans; D008297:Male; D016485:Needle Sharing; D012189:Retrospective Studies; D012307:Risk Factors; D016036:Seroepidemiologic Studies; D015819:Substance Abuse, Intravenous / Q000821:virology*