title: Cutaneous neosporosis in two adult dogs on chronic immunosuppressive therapy.
abstract: Antemortem diagnosis of generalized ulcerative and pyogranulomatous dermatitis with numerous intralesional tachyzoites was made from skin biopsy specimens from 2 adult dogs on chronic immunosuppressive therapy. A 9-year-old Italian Greyhound was on long-term corticosteroid therapy for the treatment of a lupus-like systemic autoimmune disorder, and a 7-year-old Labrador Retriever had received several months of chemotherapy for lymphosarcoma. The tachyzoites were identified as Neospora caninum by immunoperoxidase immunohistochemistry. Both dogs were treated with clindamycin. Lesions in the Greyhound resolved; however, the Labrador Retriever was euthanized because of evidence of neuromuscular disease, despite improvement of the skin lesions. These 2 cases indicate that cutaneous neosporosis can occur in adult dogs on chronic immunosuppressive therapy. The disease may result from reactivation of a congenital infection and/or a recently acquired primary infection.
authors.affiliation: Department of Veterinary Biosciences, College of Veterinary Medicine, Ohio State University, Columbus 43210, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: La Perle
authors.forename: F
authors.initials: F
authors.lastname: Del Piero
authors.forename: R F
authors.initials: RF
authors.lastname: Carr
authors.forename: C
authors.initials: C
authors.lastname: Harris
authors.forename: P C
authors.initials: PC
authors.lastname: Stromberg
mesh_terms: D000818:Animals; D003048:Coccidiosis / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology / Q000473:pathology*; D004285:Dogs; D005260:Female; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D018688:Neospora / Q000302:isolation & purification* / Q000472:pathogenicity; D009468:Neuromuscular Diseases / Q000209:etiology / Q000662:veterinary; D012871:Skin Diseases / Q000473:pathology / Q000662:veterinary*
chemical_list: D007166:Immunosuppressive Agents