Prenatal morphine exposure induces age- and sex-dependent changes in seizure susceptibility.
1. Prenatal exposure to morphine induces long-term alterations in seizure susceptibility, which are age-, sex-, and seizure model-specific. 2. Adult male and female rats exposed prenatally to morphine show decreased susceptibility to GABA-regulated seizures. 3. Prenatally morphine-exposed, adult male rats are more sensitive to excitatory amino acid receptor-mediated seizures than control males, control females, or morphine-exposed females.
Vathy
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Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx 10461, NY, USA. vathy@aecom.yu.edu
D000367:Age Factors; D000375:Aging / Q000187:drug effects; D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009294:Narcotics / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism; D012727:Sex Characteristics; D012737:Sex Factors
D009294:Narcotics; D009020:Morphine