Evaluation of model solvent systems for assessing the accumulation of container extractables in drug formulations.
The interaction between a medical device and a pharmaceutical solution it contacts may dictate solution safety and/or efficacy. Of specific concern is the ability of device components to leach into the contacting solution. As pharmaceutical solutions containing surfactants, co-solvents and solubilizing agents become more common, method's for assessing the extent of leaching are needed. In this manuscript, a model is developed which relates a solution's polarity to its ability to interact with a plastic material. The validity of the developed model is examined via direct analysis of several pharmaceutically relevant solutions.
Jenke
D R
DR
Center for Physical and Chemical Sciences, Baxter Healthcare Inc., William Graham Science Center, Round Lake, IL 60073, USA. dennis_jenke@baxter.com
D004339:Drug Compounding; D004349:Drug Packaging; D004356:Drug Storage; D008433:Mathematics; D008956:Models, Chemical; D012997:Solvents / Q000737:chemistry*
D012997:Solvents