Survey of reverse transcriptase from the heterosexual epidemic of human immunodeficiency virus type 1 CRF01_AE in Thailand from 1990 to 2000.
Genetic diversity of the HIV-1 envelope gene has shown a steady increase over time in the Thai and other regional epidemics. A serial survey of subtype CRF01_AE polymerase gene (RT) diversity in Thailand was performed, using 48 novel and 15 reported sequences covering the period 1990--2000. These sequences were gathered from individuals whose sole risk factor for infection was heterosexual contact. By contrast to envelope, diversity was low and, despite a 40% increase early in the epidemic, has remained static since 1996. These results indicate that epidemic HIV-1 may be constrained within defined limits of genetic diversity at least in some genomic regions.
Sirivichayakul
S
S
Division of Allergy and Clinical Immunology, Department of Medicine, Chulalongkorn University, Bangkok, 10330, Thailand.
Chantratita
W
W
Sutthent
R
R
Ruxrungtham
K
K
Phanuphak
P
P
Oelrichs
R B
RB
D000595:Amino Acid Sequence; D001483:Base Sequence; D004196:Disease Outbreaks; D019143:Evolution, Molecular; D005260:Female; D014644:Genetic Variation; D015699:HIV Envelope Protein gp120 / Q000145:classification / Q000235:genetics; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology / Q000821:virology*; D054303:HIV Reverse Transcriptase / Q000145:classification / Q000235:genetics*; D015497:HIV-1 / Q000145:classification / Q000235:genetics* / Q000302:isolation & purification; D020010:Heterosexuality; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008969:Molecular Sequence Data; D010802:Phylogeny; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors; D016415:Sequence Alignment; D017421:Sequence Analysis; D012749:Sexually Transmitted Diseases / Q000453:epidemiology / Q000821:virology; D013785:Thailand / Q000453:epidemiology; D013997:Time Factors
D015699:HIV Envelope Protein gp120; D054303:HIV Reverse Transcriptase