[Diaphragm-like strictures of the colon from diclofenac].
BACKGROUND
Diaphragm-like strictures of the colon induced by nonsteroidal antiinflammatory drugs (NSAID) constitute a recently described uncommon clinical entity.


METHODS
An 86-year-old man consulted for abdominal pain and constipation. The physical examination revealed bloody stools and anemia in a patient on long-standing diclofenac therapy. Colonoscopy demonstrated two diaphragm-like strictures of the left and transverse colon with ulceration of the apex. Clinical outcome was favorable after discontinuing the NSAID.


CONCLUSIONS
We compared this observation with 26 other case reports in the literature. The etiological mechanism appears to be related to systemic and local toxicity. Severe stenotic stricture may require surgical management. Endoscopic pneumatic dilatation may be an alternative to surgery.
Benoit
R
R
Service de Médecine Interne à Orientation Gastroentérologique, Centre hospitalier de Montluçon, 18, avenue du 8 Mai 1945, F03109 Montluçon.
Grobost
O
O
Crepeau
T
T
D015746:Abdominal Pain / Q000209:etiology*; D000368:Aged; D000369:Aged, 80 and over; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D003108:Colonic Diseases / Q000139:chemically induced* / Q000175:diagnosis; D003113:Colonoscopy; D003248:Constipation / Q000209:etiology*; D004008:Diclofenac / Q000009:adverse effects*; D006801:Humans; D008297:Male; D014456:Ulcer / Q000139:chemically induced* / Q000175:diagnosis
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac