title: The role of efflux in macrolide resistance.
abstract: Efflux is one of the major resistance mechanisms for macrolide antibiotics observed in both laboratory and clinical settings. This review summarizes the recent research on two major macrolide efflux pumps: Mef in Gram-positive organisms and Acr-AB-TolC in Haemophilus influenzae and Escherichia coli. The roles of pumps in macrolide resistance and the new advances / strategies to overcome efflux are discussed. Copyright 2000 Harcourt Publishers Ltd.
authors.affiliation: Infectious Disease Research, Abbott Laboratories, Abbott Park, IL, USA
authors.forename: Ping
authors.initials: P
authors.lastname: Zhong
authors.forename: Virginia D.
authors.initials: VD
authors.lastname: Shortridge