[Synthesis and antibacterial activity of tricycic fluoroquinolones].
Twelve new analogues of new tricyclic rufloxacin were prepared and their MIC were evaluated against thirteen kinds of bacteria. As a result of these studies: the polarity of C10-side chain was found to exert greater positive effect on G- than on G+ bacteria.
Xiong
W N
WN
Medicinal and Chemical Institute of China Pharmaceutical University, Nanjing 210009.
Wang
E H
EH
D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D024841:Fluoroquinolones; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C060328:rufloxacin