title: Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress.
abstract: Thioacetamide (TAA) administration (0.3 g/l of tap water for a period of 3 months) to rats resulted in hepatic cirrhosis as assessed by biochemical and histopathological findings. This treatment caused an increase in the levels of malondialdehyde (MDA) and diene conjugates (DCs) and a decrease in the levels of glutathione (GSH), vitamin E, vitamin C and the activities of glutathione peroxidase (GSH-Px) in the liver of rats. Superoxide dismutase (SOD) activities were unchanged. Taurine (2% w/w, added to the chow diet) was administered together with TAA (0.3 g/l of drinking water) for 3 months. Taurine was found to decrease TAA-induced hepatic lipid peroxidation and to increase TAA-depleted vitamin E levels and GSH-Px activities. Histopathological findings also suggested that taurine has an inhibitive effect on TAA-induced hepatic cirrhosis. These results indicate that taurine treatment has a protective effect against TAA-induced liver cirrhosis by decreasing oxidative stress.
authors.affiliation: Department of Biochemistry, Istanbul Medical Faculty, University of Istanbul, Capa, Turkey.
authors.forename: J
authors.initials: J
authors.lastname: Balkan
authors.forename: S
authors.initials: S
authors.lastname: Doğru-Abbasoğlu
authors.forename: O
authors.initials: O
authors.lastname: Kanbağli
authors.forename: U
authors.initials: U
authors.lastname: Cevikbaş
authors.forename: G
authors.initials: G
authors.lastname: Aykaç-Toker
authors.forename: M
authors.initials: M
authors.lastname: Uysal
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000009:adverse effects*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000517:prevention & control* / Q000662:veterinary; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013654:Taurine / Q000494:pharmacology*; D013853:Thioacetamide / Q000009:adverse effects*
chemical_list: D002273:Carcinogens; D013853:Thioacetamide; D013654:Taurine; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione