Improved chemical synthesis of UDP-galactofuranose.
[reaction: see text] A reliable and efficient synthetic route to UDP-alpha-D-galactofuranose (UDP-Galf) has been developed. Reaction of UMP-N-methylimidazolide with Galf 1-phosphate proceeds rapidly to provide UDP-Galf with excellent reproducibility and in a yield approximately twice as high as those reported previously.
Marlow
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Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706, USA.
Kiessling
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D005690:Galactose / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D016695:Glycosyltransferases / Q000737:chemistry; D009682:Magnetic Resonance Spectroscopy; D014530:Uridine Diphosphate / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000737:chemistry; D014542:Uridine Monophosphate / Q000737:chemistry
C104136:uridine diphosphate galactofuranose; D014530:Uridine Diphosphate; D014542:Uridine Monophosphate; D016695:Glycosyltransferases; D005690:Galactose