The development of an oocyte-containing follicle during gonadotrophin-releasing hormone agonist administration.
Administration of gonadotrophin-releasing hormone (GnRH) agonist in a 29 year old woman with infertility due to ovulatory dysfunction resulted in the development of several ovarian cysts. After human chorionic gonadotrophin (HCG) was injected, the cysts were aspirated and one mature oocyte was retrieved. Intracytoplasmic sperm injection (ICSI) was performed and the resulting embryo was transferred. A singleton pregnancy was obtained and a healthy baby was born at 36 weeks of gestation. Because GnRH agonist-derived cysts may contain oocytes, we suggest that when the growth of cysts is accompanied by high concentrations of oestradiol, the administration of HCG may be useful to achieve oocyte maturation and advance IVF treatment.
Almagor
M
M
IVF and Fertility Laboratory, Department of Obstetrics and Gynecology, Bikur Cholim Hospital, 5 Strauss St., Jerusalem 91004, Israel. almagors@hotmail.com
Hovav
Y
Y
D000328:Adult; D006063:Chorionic Gonadotropin / Q000008:administration & dosage; D004958:Estradiol / Q000008:administration & dosage; D005260:Female; D005865:Gestational Age; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D007248:Infertility, Male / Q000628:therapy; D008297:Male; D009865:Oocytes / Q000502:physiology*; D006080:Ovarian Follicle / Q000166:cytology*; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic; D013396:Suction; D020858:Tissue and Organ Harvesting; D017329:Triptorelin Pamoate / Q000008:administration & dosage*
D006063:Chorionic Gonadotropin; D017329:Triptorelin Pamoate; D004958:Estradiol