title: PNA biosensors for nucleic acid detection.
abstract: Biosensor devices, based on the conversion of nucleic acid recognition reactions into useful electrical signals, offer considerable promise for DNA diagnostics. The unique hybridization properties of solution-phase PNA can be extrapolated onto transducer surfaces in connection with the design of remarkably specific DNA biosensors. This article reviews the development of PNA biosensors, and discusses common PNA-biosensing protocols along with their prospects in DNA biosensor technology.
authors.affiliation: Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA.
authors.forename: J
authors.initials: J
authors.lastname: Wang
mesh_terms: D015374:Biosensing Techniques; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D009693:Nucleic Acid Hybridization / Q000379:methods*; D020135:Peptide Nucleic Acids / Q000235:genetics / Q000378:metabolism*; D014159:Transducers
chemical_list: D020135:Peptide Nucleic Acids; D004247:DNA