A prospective controlled study of karyotyping for 430 consecutive babies conceived through intracytoplasmic sperm injection.
OBJECTIVE
To compare the karyotype of babies conceived through ICSI with that of naturally conceived babies.


METHODS
Prospective controlled study.


METHODS
The Egyptian IVF-ET Center, Cairo, Egypt.


METHODS
Four hundred and thirty babies conceived through ICSI and 430 babies conceived naturally.


METHODS
ICSI and karyotyping.


METHODS
Abnormal karyotype.


RESULTS
Four hundred and thirty consecutive babies conceived through ICSI who were delivered in one hospital had 15 abnormal karyotypes (3.5%). Of the 15 babies, 7 were of female phenotype and 8 of male phenotype. Six babies had sex chromosome anomalies, 8 had autosomal anomalies, and 1 had combined sex chromosome and autosomal anomalies. A control group of 430 consecutive babies conceived naturally who were delivered in one hospital had no abnormal karyotype. The difference between the two groups was significant (P<.001).


CONCLUSIONS
ICSI carries a small but significant increased risk of abnormal karyotyping to the offspring. This risk appears to be equally distributed between autosomal and sex chromosome anomalies.
Aboulghar
H
H
The Egyptian IVF-ET Center, Egypt. ghar@intouch.com
Aboulghar
M
M
Mansour
R
R
Serour
G
G
Amin
Y
Y
Al-Inany
H
H
D000328:Adult; D002869:Chromosome Aberrations / Q000209:etiology* / Q000235:genetics; D025063:Chromosome Disorders; D004534:Egypt; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D011446:Prospective Studies; D012729:Sex Chromosome Aberrations / Q000209:etiology; D020554:Sperm Injections, Intracytoplasmic / Q000009:adverse effects*