[Possible role of the pineal gland in the pathogenesis of idiopathic scoliosis. Experimental and clinical studies].
The unexpected finding in 1959 by Marie-Jeanne Thillard that pinealectomy in young chickens gives way to spinal deformities was confirmed by the authors. In another experiment they found that injected melatonine to the chick at adequate dose and at the same time as surgery, lessen or even totally prevents the occurrence of deformities. On the other hand, at too low dose or delayed after pinealectomy melatonine injection, may not prevent the deformity which will be persisting or even increasing. In a subsequent series of experiments on the rat, pinealectomy results in decreasing the plasmatic amount of melatonine as well as giving way to spinal deformities. The nature of these deformities observed here is dependent on the stature between of the animal. The normal quadrupede rat develops after pinealectomy a standard scoliosis. Inversely the scoliotic deformity occurs when the animal has been forced to a bipede condition, which may be achieved by removing its forelimbs when baby, then forcing it to stand and remain in erect posture by high enough feeding. Melatonine depressing and erect position are in two conditions, when associated, likely to give way to experimental scoliosis. In human, a low nycthemeral level of plasmatic melatonine is correlated with progressive scoliosis. The level of platelets calmoduline, when is normally modulated by melatonine, has been proved by Kindsfater to be increased in progressive scoliosis. Then raises the hypothesis that human idiopathic scoliosis may be due to an inherited disorder of neuro-transmitters from neuro-hormonal origin, associated with bipedal condition, where an horizontal localized neuro-muscular imbalance starts and produces the scoliotic deformity of the fibro-elastic and bony structures axial spinal pilar.
Dubousset
J
J
Hôpital Saint-Vincent-de-Paul-Université Réné Descartes, Département de Chirurgie orthopédique, 74-82 avenue Denfert Rochereau-75674 Paris.
Machida
M
M
D000818:Animals; D001792:Blood Platelets / Q000737:chemistry; D002147:Calmodulin / Q000032:analysis / Q000502:physiology; D002645:Chickens; D004195:Disease Models, Animal; D018450:Disease Progression; D013006:Growth Hormone / Q000502:physiology; D006801:Humans; D008550:Melatonin / Q000502:physiology / Q000627:therapeutic use; D010870:Pineal Gland / Q000503:physiopathology* / Q000601:surgery; D011187:Posture / Q000502:physiology; D051381:Rats; D012600:Scoliosis / Q000209:etiology* / Q000517:prevention & control
D002147:Calmodulin; D013006:Growth Hormone; D008550:Melatonin