Inhibition of cytokine production and interference in IL-2 receptor-mediated Jak-Stat signaling by the hydroxylamine metabolite of sulfamethoxazole.
Hess
D A
DA
Department of Pharmacology and Toxicology, University of Western Ontario, London, Ontario, Canada.
O'Leary
E F
EF
Lee
J T
JT
Almawi
W Y
WY
Madrenas
J
J
Rieder
M J
MJ
D016207:Cytokines / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D053613:Janus Kinase 1; D053616:Janus Kinase 3; D008894:Milk Proteins; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015375:Receptors, Interleukin-2 / Q000502:physiology*; D050796:STAT3 Transcription Factor; D050799:STAT5 Transcription Factor; D015398:Signal Transduction / Q000187:drug effects*; D013420:Sulfamethoxazole / Q000031:analogs & derivatives / Q000494:pharmacology*; D015534:Trans-Activators / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D016207:Cytokines; D004268:DNA-Binding Proteins; D007375:Interleukin-1; D008894:Milk Proteins; D015375:Receptors, Interleukin-2; D050796:STAT3 Transcription Factor; C494086:STAT3 protein, human; D050799:STAT5 Transcription Factor; D015534:Trans-Activators; D014409:Tumor Necrosis Factor-alpha; C059873:sulfamethoxazole hydroxylamine; D015847:Interleukin-4; D007371:Interferon-gamma; D011505:Protein-Tyrosine Kinases; C507904:JAK1 protein, human; C507933:JAK3 protein, human; D053613:Janus Kinase 1; D053616:Janus Kinase 3; D013420:Sulfamethoxazole