The phosphatidylserine receptor: a crucial molecular switch?
The uptake and removal of necrotic or lysed cells involves inflammation and an immune response, due in part to processes that involve members of the collectin family, surface calreticulin and CD91. Clearance of apoptotic cells, by contrast, does not induce either inflammation or immunity. Could the phosphatidylserine receptor be the molecular switch that determines what the outcome will be?
Henson
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PM
Program in Cell Biology, Department of Pediatrics, National Jewish Medical and Research Center, 1400 Jackson Street, Denver, Colorado 80206, USA. hensonp@njc.org
Bratton
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DL
Fadok
V A
VA
D000818:Animals; D017951:Antigen Presentation; D017209:Apoptosis / Q000502:physiology; D002135:Calcium-Binding Proteins / Q000502:physiology; D037282:Calreticulin; D002352:Carrier Proteins / Q000502:physiology; D002448:Cell Adhesion; D016923:Cell Death / Q000502:physiology*; D016922:Cellular Senescence; D037222:Collectins; D003713:Dendritic Cells / Q000502:physiology; D010450:Endopeptidases / Q000502:physiology; D006801:Humans; D007249:Inflammation; D018836:Inflammation Mediators / Q000378:metabolism; D056484:Jumonji Domain-Containing Histone Demethylases; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008563:Membrane Lipids / Q000502:physiology; D008954:Models, Biological; D009336:Necrosis; D010587:Phagocytosis / Q000502:physiology; D010718:Phosphatidylserines / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D011971:Receptors, Immunologic / Q000502:physiology; D012261:Ribonucleoproteins / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology
D002135:Calcium-Binding Proteins; D037282:Calreticulin; D002352:Carrier Proteins; D037222:Collectins; D018836:Inflammation Mediators; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D008563:Membrane Lipids; D010718:Phosphatidylserines; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D012261:Ribonucleoproteins; D016212:Transforming Growth Factor beta; C408123:phosphatidylserine receptor; C498707:JMJD6 protein, human; D056484:Jumonji Domain-Containing Histone Demethylases; D010450:Endopeptidases