Can drugs or micronutrients prevent cataract?
Cataract is the major cause of blindness and of visual impairment worldwide, so its prevention is of the greatest importance. At present no drug therapy is licensed for use in the UK or the US, so the only treatment for cataract is by surgery, which is expensive and has adverse effects. This article reviews research on prevention of cataract by a variety of agents, including micronutrients as well as drugs. Benefits have been claimed for many compounds or mixtures and this review concentrates on those most extensively studied. Information on possible benefits of putative anticataract agents comes from a variety of approaches, from laboratory experiments, both in vitro and in vivo, to epidemiological studies in patients. Sorbitol-lowering drugs were the first to be examined systematically and progressed to clinical trials which were disappointing, and now the entire rationale for their use in prevention of cataract is questionable. Micronutrients showed little promise in animals but came to clinical trial in patients with cataract without the publication of any major benefit. Pantethine showed more promise in animal studies but the only clinical trial was abandoned early. A variety of laboratory and epidemiological evidence supports the benefits of aspirin-like drugs but there has been no trial specifically in patients with cataract. Add-on studies to trials of aspirin for other indications have not been encouraging. Research into other compounds is interesting but less advanced.
Harding
J J
JJ
Nuffield Laboratory of Ophthalmology, University of Oxford, England. john.harding@eye.ox.ac.uk
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors; D001241:Aspirin / Q000627:therapeutic use; D002386:Cataract / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D015195:Drug Design; D004967:Estrogens / Q000627:therapeutic use; D005978:Glutathione / Q000627:therapeutic use; D006801:Humans; D010204:Pantetheine / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004967:Estrogens; D010204:Pantetheine; C005425:pantethine; D000449:Aldehyde Reductase; D005978:Glutathione; D001241:Aspirin