title: Significant pelvic recurrence in high-risk pathologic stage I--IV endometrial carcinoma patients after adjuvant chemotherapy alone: implications for adjuvant radiation therapy.
abstract: OBJECTIVE
  To evaluate the risk of pelvic recurrence (PVR) in high-risk pathologic Stage I--IV endometrial carcinoma patients after adjuvant chemotherapy alone.
  
  
  METHODS
  Between 1992 and 1998, 43 high-risk endometrial cancer patients received adjuvant chemotherapy. All patients underwent primary surgery consisting of total abdominal hysterectomy and bilateral salpingo-oophorectomy. No patients received preoperative radiation therapy (RT). Regional lymph nodes and peritoneal cytology were sampled in 62.8% and 83.7% of cases, respectively. Most patients had Stage III--IV disease (83.7%) or unfavorable histology tumors (74.4%). None had evidence of extra-abdominal disease. All patients received 4-6 cycles of chemotherapy as the sole adjuvant therapy, consisting primarily of cisplatin and doxorubicin. Recurrent disease sites were divided into pelvic (vaginal, nonvaginal) and extrapelvic (para-aortic, upper abdomen, liver, and extra-abdominal). Median follow-up was 27 months (range, 2--96 months).
  
  
  RESULTS
  Twenty-nine women (67.4%) relapsed. Seventeen (39.5%) recurred in the pelvis and 23 (55.5%) in extrapelvic sites. The 3-year actuarial PVR rate was 46.5%. The most significant factors correlated with PVR were cervical involvement (CI) (p = 0.01) and adnexal (p = 0.05) involvement. Of the 17 women who developed a PVR, 8 relapsed in the vagina, 3 in the nonvaginal pelvis, and 6 in both. The 3-year vaginal and nonvaginal PVR rates were 37.8% and 26%, respectively. The most significant factor correlated with vaginal PVR was CI (p = 0.0007). Deep myometrial invasion (p = 0.02) and lymph nodal involvement (p = 0.03) were both correlated with nonvaginal PVR. Nine of the 29 relapsed patients (31%) developed PVR as their only (6) or first site (3) of recurrence. Factors associated with a higher rate of PVR (as the first or only site) were CI and Stage I--II disease.
  
  
  CONCLUSIONS
  PVR is common in high-risk pathologic Stage I-IV endometrial cancer patients after adjuvant chemotherapy alone. These results support the continued use of locoregional RT in patients undergoing adjuvant chemotherapy. Further studies are needed to test the addition of chemotherapy to locoregional RT.
authors.affiliation: Department of Radiation and Cellular Oncology, Section of Gynecologic Oncology, University of Chicago Hospitals, Chicago, IL 60637, USA. mundt@rover.uchicago.edu
authors.forename: A J
authors.initials: AJ
authors.lastname: Mundt
authors.forename: R
authors.initials: R
authors.lastname: McBride
authors.forename: J
authors.initials: J
authors.lastname: Rotmensch
authors.forename: S E
authors.initials: SE
authors.lastname: Waggoner
authors.forename: S D
authors.initials: SD
authors.lastname: Yamada
authors.forename: P P
authors.initials: PP
authors.lastname: Connell
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000517:prevention & control / Q000556:secondary* / Q000628:therapy; D018262:Adenocarcinoma, Clear Cell / Q000453:epidemiology / Q000517:prevention & control / Q000556:secondary / Q000628:therapy; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D018196:Carcinoma, Adenosquamous / Q000453:epidemiology / Q000517:prevention & control / Q000556:secondary / Q000628:therapy; D017024:Chemotherapy, Adjuvant; D002641:Chicago / Q000453:epidemiology; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D018283:Cystadenocarcinoma, Papillary / Q000453:epidemiology / Q000517:prevention & control / Q000556:secondary / Q000628:therapy; D004317:Doxorubicin / Q000008:administration & dosage; D016889:Endometrial Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007044:Hysterectomy; D015993:Life Tables; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010052:Ovariectomy; D010386:Pelvic Neoplasms / Q000453:epidemiology / Q000517:prevention & control / Q000556:secondary*; D018714:Radiotherapy, Adjuvant; D012189:Retrospective Studies; D012306:Risk; D016896:Treatment Outcome; D014625:Vaginal Neoplasms / Q000453:epidemiology / Q000517:prevention & control / Q000556:secondary
chemical_list: D004317:Doxorubicin; D002945:Cisplatin