title: A novel superfamily of enzymes that catalyze the modification of guanidino groups.
abstract: Three enzymes, peptidyl-arginine deiminase from Porphyromonas gingivalis, arginine deiminase and amidinotransferase are traditionally classified separately. By combining PSI-BLAST and FUGUE, data presented in this article describe how these enzymes belong to a novel superfamily, adopting a common fold and sharing similar catalytic mechanisms.
authors.affiliation: Dept of Biochemistry, University of Cambridge, Old Addenbrookes Site, 80 Tennis Court Road, CB2 1GA, Cambridge, UK.
authors.forename: H
authors.initials: H
authors.lastname: Shirai
authors.forename: T L
authors.initials: TL
authors.lastname: Blundell
authors.forename: K
authors.initials: K
authors.lastname: Mizuguchi
mesh_terms: D000579:Amidinotransferases / Q000737:chemistry / Q000378:metabolism*; D000595:Amino Acid Sequence; D002384:Catalysis; D006146:Guanidines / Q000378:metabolism*; D006867:Hydrolases / Q000737:chemistry / Q000378:metabolism*; D008969:Molecular Sequence Data; D016966:Porphyromonas gingivalis / Q000201:enzymology; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases; D017386:Sequence Homology, Amino Acid
chemical_list: D006146:Guanidines; D000579:Amidinotransferases; D006867:Hydrolases; D000080002:Protein-Arginine Deiminase Type 4; D000076342:Protein-Arginine Deiminases; C019723:arginine deiminase