Molecular diversity in the biosynthesis of GI tract glycoconjugates. A blood-group-related chart of microorganism receptors.
This paper examines the potential of carbohydrate blood-group antigens present on mucosal surfaces in acting as receptors for microorganisms. Mucosal surfaces express significant amounts of carbohydrate blood-group antigens under the control of the Secretor, Lewis and ABO systems. The exact glycoconjugate profile an individual presents to the lumen is complex, and can only be correctly determined by a combination of serology and genotyping. We have isolated and structurally resolved the glycolipids expressed in the small intestine of group O individuals having various common or rare phenotypes. Using this information, we have been able to construct a biosynthetic pathway and propose that the type, size and glycotopes expressed, are controlled to a major extent by blood-group-related glycosyltransferases. Many of these glycotopes are potential receptors for microorganisms; some resemble tumour antigens, while others resemble the lipopolysaccharides of some pathogens. Although the origins of the blood-group glycosyltransferases remain uncertain, it is evident that they significantly diversify the mucosal glycotopes exposed to microbes; and therein may be found a potential explanation for their existence.
Henry
S M
SM
Glycosciences Research Centre, Auckland University of Technology, New Zealand. kiwi@aut.ac.nz
D000017:ABO Blood-Group System / Q000235:genetics / Q000502:physiology; D018829:Adhesins, Bacterial / Q000378:metabolism; D000328:Adult; D000818:Animals; D001422:Bacterial Adhesion; D001789:Blood Group Antigens / Q000737:chemistry / Q000502:physiology*; D019143:Evolution, Molecular; D005643:Fucose / Q000378:metabolism; D005647:Fucosyltransferases / Q000235:genetics / Q000502:physiology; D006001:Glycoconjugates / Q000096:biosynthesis / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D006017:Glycolipids / Q000737:chemistry / Q000276:immunology / Q000502:physiology; D006031:Glycosylation; D015186:Hominidae / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000382:microbiology; D007421:Intestine, Small / Q000737:chemistry; D007983:Lewis Blood Group Antigens / Q000235:genetics / Q000502:physiology; D008070:Lipopolysaccharides / Q000737:chemistry / Q000276:immunology; D009682:Magnetic Resonance Spectroscopy; D018716:Molecular Mimicry; D011499:Protein Processing, Post-Translational; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013329:Structure-Activity Relationship; D014774:Virulence; D000097631:Galactoside 2-alpha-L-fucosyltransferase
D000017:ABO Blood-Group System; D018829:Adhesins, Bacterial; D001789:Blood Group Antigens; D005643:Fucose; D005647:Fucosyltransferases; D006001:Glycoconjugates; D006017:Glycolipids; D007983:Lewis Blood Group Antigens; D008070:Lipopolysaccharides; D000097631:Galactoside 2-alpha-L-fucosyltransferase