title: Changes in serum concentration of antioxidants following treadmill exercise testing in patients with suspected ischaemic heart disease.
abstract: Twenty-four subjects with suspected ischaemic heart disease underwent a treadmill exercise stress test (TEST). Nine individuals developed ischaemia as defined by standard criteria. Total plasma antioxidant status (TPAS), and serum concentrations of vitamin E were measured pre-TEST, and 0, 1, 2, 4, 8 and 24 h following the treadmill test. Mean serum vitamin E concentrations fell by 33% in the group as a whole (from 9.53 +/- 0.92 mg/L pre-TEST to 6.39 +/- 1.06 mg/L immediately post stress test, P < 0.02) and rose to baseline over the subsequent 24 h. The levels of serum vitamin E fell by 34% in the group of patients who had a positive TEST, and 32% in those who did not develop ischaemia during the TEST. Serum cholesterol concentrations also fell significantly during the TEST. In the total group serum cholesterol fell by 6.5% (P = 0.0052), and in the subgroup who were positive for ischaemia the fall in serum cholesterol was 10.3% (P = 0.004). The reduction in serum cholesterol was 4.1% in the subgroup who did not develop ischaemia (P > 0.05). Mean total plasma antioxidant status showed no significant temporal change for the group as a whole, although there was a nonsignificant decrease immediately post-TEST in the ischaemic group and a slight rise at 8 h in the group negative for ischaemia.
authors.affiliation: Centre for Clinical Science and Measurement, University of Surrey, UK.
authors.forename: M E
authors.initials: ME
authors.lastname: Ashmaig
authors.forename: B J
authors.initials: BJ
authors.lastname: Starkey
authors.forename: A M
authors.initials: AM
authors.lastname: Ziada
authors.forename: A
authors.initials: A
authors.lastname: Amro
authors.forename: S
authors.initials: S
authors.lastname: Sobki
authors.forename: G A
authors.initials: GA
authors.lastname: Ferns
mesh_terms: D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood*; D014810:Vitamin E / Q000097:blood
chemical_list: D000975:Antioxidants; D014810:Vitamin E; D002784:Cholesterol