Sex and salt hormones: rapid effects in epithelia.
Recent evidence points to protein kinase C isoforms as highly specific receptors for aldosterone and estradiol in epithelia. The end targets of the kinase activation are Na(+)/H(+) exchange and K(+) and Ca(2+) channels. The physiological role of the nongenomic response is to increase electrolyte absorption and inhibit secretion in pluripotential epithelia.
Harvey
B J
BJ
Wellcome Trust Cellular Physiology Research Unit, Department of Physiology, University College Cork, Ireland.
Condliffe
S
S
Doolan
C M
CM
D000450:Aldosterone / Q000502:physiology*; D000818:Animals; D004848:Epithelium / Q000502:physiology; D004958:Estradiol / Q000502:physiology*; D006801:Humans; D012727:Sex Characteristics; D015398:Signal Transduction / Q000502:physiology
D000450:Aldosterone; D004958:Estradiol