title: Uterine sarcomas in South African black women: a clinicopathologic study with ethnic considerations.
abstract: BACKGROUND
  There is considerable evidence for a higher incidence of uterine sarcomas in blacks when compared to whites. However, whether this higher incidence is related to differences in clinicopathologic presentation is not known.
  
  
  METHODS
  We reviewed slides and clinical charts of 81 patients with a primary diagnosis of uterine sarcoma referred between 1991 and 1999 to Kalafong Academic and Pretoria Academic Hospital. After review, 49 cases remained for study.
  
  
  RESULTS
  Uterine sarcomas were distributed between leiomyosarcoma (LMS) (39%), carcinosarcoma (CS) (49%) and endometrial stromal sarcoma (ESS) (12%). LMS and ESS tend to present at an earlier age when compared to CS (respectively p < 0.008 and 0.02). Of women with LMS more women are premenopausal when compared to CS (p < 0.009). Lower abdominal pain is more common in LMS (p < 0.009), whereas bleeding is more common in women suffering from CS (p < 0.01). Lymphovascular space involvement and cervical involvement are more common in CS when compared to LMS. In CS, the carcinoma component has most of the metastatic potential.
  
  
  CONCLUSIONS
  Among black South African women different clinicopathologic features for uterine LMS, CS and ESS are observed. We also present genetic and/or hormonal factors possibly contributing to the pathophysiology of uterine sarcomas in blacks.
authors.affiliation: Department of Obstetrics and Gynaecology, Pretoria Academic Hospital, South Africa.
authors.forename: F
authors.initials: F
authors.lastname: Amant
authors.forename: L
authors.initials: L
authors.lastname: Dreyer
authors.forename: J
authors.initials: J
authors.lastname: Makin
authors.forename: I
authors.initials: I
authors.lastname: Vergote
authors.forename: B G
authors.initials: BG
authors.lastname: Lindeque
mesh_terms: D000367:Age Factors; D044383:Black People / Q000235:genetics*; D002296:Carcinosarcoma / Q000208:ethnology / Q000473:pathology; D005260:Female; D006801:Humans; D015994:Incidence; D007890:Leiomyosarcoma / Q000208:ethnology / Q000473:pathology; D008875:Middle Aged; D012509:Sarcoma / Q000208:ethnology* / Q000235:genetics / Q000473:pathology*; D018203:Sarcoma, Endometrial Stromal / Q000208:ethnology / Q000473:pathology; D013019:South Africa / Q000453:epidemiology; D014594:Uterine Neoplasms / Q000208:ethnology* / Q000235:genetics / Q000473:pathology*