Two-week, but not 1-week, hypoxic exposure enhances nitric oxide-mediated basal tone regulation in rat resistance pulmonary arteries.
We measured internal diameter (ID) changes in resistance and conduit pulmonary arteries of 1- and 2-week hypoxic rats and normoxic control rats in response to nitric oxide synthase (NOS) inhibitors in vivo. At 2 weeks of hypoxic exposure, the ID reduction as a result of NOS inhibition was enhanced within the resistance arteries, but not at 1 week of hypoxia.
Shirai
M
M
National Cardiovascular Center Research Institute, Osaka, 565-8565 Japan. mshiraim@res.ncvc.go.jp
Shimouchi
A
A
Ikeda
S
S
Oya
H
H
Min
K Y
KY
Kawaguchi
A T
AT
Mori
H
H
Ninomiya
I
I
D000818:Animals; D000831:Animals, Newborn; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009569:Nitric Oxide / Q000494:pharmacology*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D011651:Pulmonary Artery / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors; D014655:Vascular Resistance / Q000502:physiology*
D009569:Nitric Oxide; D019001:Nitric Oxide Synthase