Trypanosome lytic factors: novel mediators of human innate immunity.
A novel trypanosome lytic factor (TLF) has been characterized that protects humans from infection by Trypanosoma brucei brucei. The mechanism of trypanolysis is unknown; contrary to one hypothesis, TLF does not kill trypanosomes by generating oxygen radicals. However, these trypanosomes become human-infective when they express a serum-resistance-associated gene.
Raper
J
J
Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA. Jayne.Raper@med.nyu.edu
Portela
M P
MP
Lugli
E
E
Frevert
U
U
Tomlinson
S
S
D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D008075:Lipoproteins, HDL / Q000276:immunology*; D014346:Trypanosoma brucei brucei / Q000276:immunology* / Q000472:pathogenicity; D014353:Trypanosomiasis, African / Q000276:immunology*
D008075:Lipoproteins, HDL