Effect of thermosensitive liposomal doxorubicin with hyperthermia on primary tumor and lung metastases in hamster osteosarcoma.
We evaluated the effect of intravenous thermosensitive liposomal doxorubicin (TL-DOX) together with local hyperthermia on primary tumors in highly metastatic hamster osteosarcoma. This combination resulted in higher DOX concentrations in plasma, primary tumors and lungs than standard DOX under the same conditions. Tumor growth and lung metastasis were also inhibited more by TL-DOX and hyperthermia than by hyperthermia alone, DOX with or without hyperthermia, and TL-DOX without hyperthermia. In addition, gains in hamster body weight were not suppressed. These results suggest that the combination of TL-DOX and hyperthermia can control primary tumors and suppress lung metastasis in hamsters.
Shimose
S
S
Department of Orthopaedic Surgery, Faculty of Medicine, Hiroshima University, 1-2-3 Kazumi, Minami-Ku, Hiroshima 734-8551, Japan. shimoses@mcai.med.hiroshima-u.ac.jp
Sugita
T
T
Nitta
Y
Y
Kubo
T
T
Ikuta
Y
Y
Murakami
T
T
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D001835:Body Weight / Q000187:drug effects; D001859:Bone Neoplasms / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D002455:Cell Division; D003131:Combined Modality Therapy; D006224:Cricetinae; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006979:Hyperthermia, Induced; D015994:Incidence; D008081:Liposomes; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary / Q000628:therapy*; D008647:Mesocricetus; D012516:Osteosarcoma / Q000378:metabolism / Q000556:secondary / Q000628:therapy*; D014018:Tissue Distribution; D016896:Treatment Outcome
D000970:Antineoplastic Agents; D008081:Liposomes; D004317:Doxorubicin