Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized.
Neurogenic genes in the Notch receptor-mediated signaling pathway play important roles in neuronal cell fate specification as well as neuronal differentiation. The Drosophila neuralized gene is one of the neurogenic genes. We have cloned a mouse homolog of Drosophila neuralized, m-neu1, and found that the m-neu1 transcript is expressed in differentiated neurons. Mice deficient for m-neu1 are viable and morphologically normal, but exhibit specific defects in olfactory discrimination and hypersensitivity to ethanol. These findings reveal an essential role of m-neu1 in ensuring proper processing of certain information in the adult brain.
Ruan
Y
Y
Departments of Physiology and Biochemistry, Howard Hughes Medical Institute, University of California, San Francisco 94143, USA.
Tecott
L
L
Jiang
M M
MM
Jan
L Y
LY
Jan
Y N
YN
D000595:Amino Acid Sequence; D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000235:genetics; D001362:Avoidance Learning; D015152:Blotting, Northern; D001923:Brain Chemistry; D018076:DNA, Complementary / Q000235:genetics; D004192:Discrimination, Psychological; D029721:Drosophila Proteins; D004331:Drosophila melanogaster / Q000235:genetics; D004351:Drug Resistance / Q000235:genetics; D000431:Ethanol / Q000633:toxicity*; D015723:Gene Library; D005838:Genotype; D045782:Hemiterpenes; D019476:Insect Proteins / Q000235:genetics; D008025:Ligases; D008297:Male; D018782:Maze Learning; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D009474:Neurons / Q000378:metabolism; D009812:Odorants; D000857:Olfaction Disorders / Q000235:genetics*; D010421:Pentanoic Acids; D020133:Reverse Transcriptase Polymerase Chain Reaction; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012903:Smell / Q000235:genetics*; D013045:Species Specificity; D044767:Ubiquitin-Protein Ligases
D018076:DNA, Complementary; D029721:Drosophila Proteins; D045782:Hemiterpenes; D019476:Insect Proteins; D009419:Nerve Tissue Proteins; D010421:Pentanoic Acids; C008216:isovaleric acid; D000431:Ethanol; D044767:Ubiquitin-Protein Ligases; C071006:neur protein, Drosophila; D008025:Ligases