Natural-product-like chiral derivatives by solid-phase synthesis.
In this genomics and proteomics age, highly functionalized natural products or natural-product-like compounds are likely to play important roles in understanding the functions of emerging biological targets because they serve as small-molecule chemical probes in modulating a target's specific actions (i.e. activation or deactivation). Development of stereoselective reaction-derived methods on solid phase provides a means of obtaining functionalized chiral core structures that may be used for high-throughout syntheses.
Arya
P
P
Chemical Biology Program, Steacie Institute for Molecular Sciences, National Research Council of Canada, 100 Sussex Drive, K1A 0R6, Ottawa, Ontario, Canada. Prabhat.Arya@nrc.ca
Baek
M
M
D000818:Animals; D001685:Biological Factors / Q000138:chemical synthesis* / Q000737:chemistry*; D015394:Molecular Structure; D013237:Stereoisomerism
D001685:Biological Factors