Drug-induced linear IgA bullous disease following antibiotics.
A 69-year-old woman presented with pneumonia and subacute bacterial endocarditis. Nine days after intravenous vancomycin and ciprofloxacin were commenced, the patient developed a bullous mucocutaneous eruption. Clinical presentation and histopathology were consistent with drug-induced linear IgA bullous disease (LABD). The patient's lesions resolved with cessation of antibiotics. A review of the features of drug-induced LABD and the drugs that have been implicated are presented.
Wiadrowski
T P
TP
Flinders Medical Centre, Bedford Park and Royal Adelaide Hospital, Adelaide, South Australia, Australia.
Reid
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CM
D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects*; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001132:Arm; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004697:Endocarditis, Bacterial / Q000150:complications / Q000188:drug therapy; D005260:Female; D005528:Foot; D006801:Humans; D007262:Infusions, Intravenous; D011014:Pneumonia / Q000150:complications / Q000188:drug therapy; D012872:Skin Diseases, Vesiculobullous / Q000139:chemically induced* / Q000473:pathology; D014640:Vancomycin / Q000008:administration & dosage / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D002939:Ciprofloxacin; D014640:Vancomycin