title: Effect of epsilon-aminocaproylaminoacids on the activity of proteolytic enzymes.
abstract: Effect of three epsilon-aminocaproylaminoacids with significant antifibrinolytic activity on chymotrypsin, trypsin, cathepsin B, cathepsin C and cathepsin D activities was examined. Slight inhibition of trypsin and chymotrypsin activity was observed only at high concentrations of these compounds. All tested dipeptides did not influence activities of cathepsin B, cathepsin C and cathepsin D.
authors.affiliation: Institute of Chemistry, University of Białystok, Poland.
authors.forename: I
authors.initials: I
authors.lastname: Bruzgo
authors.forename: K
authors.initials: K
authors.lastname: Midura-Nowaczek
authors.forename: W
authors.initials: W
authors.lastname: Roszkowska-Jakimiec
authors.forename: J
authors.initials: J
authors.lastname: Jasielczuk
mesh_terms: D015119:Aminocaproic Acid / Q000494:pharmacology*; D000933:Antifibrinolytic Agents / Q000494:pharmacology*; D002401:Cathepsin B / Q000037:antagonists & inhibitors; D020789:Cathepsin C / Q000037:antagonists & inhibitors; D002402:Cathepsin D / Q000037:antagonists & inhibitors; D011480:Protease Inhibitors / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000494:pharmacology
chemical_list: D000933:Antifibrinolytic Agents; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D020789:Cathepsin C; D002401:Cathepsin B; D002402:Cathepsin D; D015119:Aminocaproic Acid