title: [Study on effect of Erigeron injection in prevention and treatment of cerebral ischemic injury].
abstract: OBJECTIVE
  To study the effect of Erigeron injection (EI) on cerebral ischemic injury.
  
  
  METHODS
  Animal model of brain ischemic/reperfusion was established in male Wistar rats and the effect of EI on proteinkinase C (PKC) activity, intraneuronal free calcium and regional cortex blood flow (rCBF) were observed.
  
  
  RESULTS
  EI could prevent the activation of PKC, calcium overload and decrease of RCBF induced by cerebral ischemia/reperfusion.
  
  
  CONCLUSIONS
  EI could prevent neuronal ischemic injury by inhibiting activation of PKC.
authors.affiliation: Southwest Hospital, Third Military Medical College, Chongqing.
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: W
authors.initials: W
authors.lastname: Dong
mesh_terms: D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy / Q000517:prevention & control*
chemical_list: D004365:Drugs, Chinese Herbal; D011493:Protein Kinase C