Prostaglandins: biphasic dose responses.
Biphasic dose responses induced by prostaglandins are documented and assessed with respect to quantitative features of their dose-response functions, mechanistic foundation, and biological generalizability. Biphasic responses were seen for multiple endpoints, including DNA synthesis, neutrophil migration, corticosterone production, fibroblast proliferation, and other parameters. In addition, numerous nonsteroidal antiinflammatory agents and other drugs alter prostaglandin concentrations and/or transport in a biphasic dose- response manner. These findings have considerable implications for the understanding of basic biological regulatory processes as well as clinical practices.
Calabrese
E J
EJ
Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu
D000305:Adrenal Cortex Hormones / Q000096:biosynthesis; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D002455:Cell Division; D002465:Cell Movement / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects / Q000502:physiology; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D008962:Models, Theoretical; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D011453:Prostaglandins / Q000494:pharmacology*
D000305:Adrenal Cortex Hormones; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins; D004247:DNA