Expression of MyoD and myogenin in muscles of mice experimentally infected with Trichinella spiralis or Trichinella pseudospiralis.
We developed a detection system for myogenic regulatory factors such as MyoD and myogenin. Adapting the method we performed a longitudinal analysis of such regulatory factors after infection with T. spiralis and T. pseudospiralis. MyoD and myogenin were expressed from the early phase of cystogenesis in T. spiralis infection. The expression returned to the normal level after 18 days from the infection when the cyst was complete. In T. pseudospiralis infection, they were also expressed from the early phase of cystogenesis, but continuously expressed at least up to 43 days post infection.
Wu
Z
Z
Department of Parasitology, Gifu University School of Medicine, Tsukasa 40, Gifu, 500-8705, Japan.
Matsuo
A
A
Nakada
T
T
Nagano
I
I
Takahashi
Y
Y
D000818:Animals; D051379:Mice; D018482:Muscle, Skeletal / Q000378:metabolism* / Q000469:parasitology*; D017570:MyoD Protein / Q000235:genetics*; D018008:Myogenin / Q000235:genetics*; D018510:RNA, Helminth / Q000235:genetics / Q000302:isolation & purification; D020133:Reverse Transcriptase Polymerase Chain Reaction; D014234:Trichinella / Q000472:pathogenicity*; D017160:Trichinella spiralis / Q000472:pathogenicity*; D014235:Trichinellosis / Q000235:genetics*
D017570:MyoD Protein; C503801:Myog protein, mouse; D018008:Myogenin; D018510:RNA, Helminth