title: Overlapping cross-sections significantly improve the reproducibility of coronary calcium measurements by electron beam tomography: a phantom study.
abstract: OBJECTIVE
  We conducted phantom studies to investigate whether overlapping cross-sections and volumetric scoring would significantly improve interscan reproducibility of electron beam tomography (EBT) for coronary artery calcium quantification.
  
  
  METHODS
  Fifteen phantoms simulating various amounts of coronary calcification were scanned in five different positions with a slice thickness of 3.0 mm and a table feed of 3.0, 2.5, and 2.0 mm. For the conventional "Agatston score" and a "volume score" (total volume of calcified lesions), interscan variabilities were compared between the three image acquisition protocols.
  
  
  RESULTS
  Agatston score variability was significantly lower for the 2.0 mm table feed than for the 3.0 or 2.5 mm table feed (3.0 mm: 22.9 +/- 10.3%; 2.5 mm: 13.6 +/- 8.2%; 2.0 mm: 8.9 +/- 5.5%). Volume score variability was significantly lower for 2.5 and 2.0 mm table feed than for 3.0 mm table feed (3.0 mm: 21.7 +/- 11.0%; 2.5 mm: 10.9 +/- 5.9%; 2.0 mm: 9.8 +/- 5.9%).
  
  
  CONCLUSIONS
  Overlapping cross-sections, especially in combination with volumetric scoring, significantly improved interscan reproducibility of EBT calcium quantification in a phantom study.
authors.affiliation: Department of Internal Medicine II, University of Erlangen-Nürnberg, Erlangen, Germany. stephan.achenbach@rzmail.uni-erlangen.de
authors.forename: S
authors.initials: S
authors.lastname: Achenbach
authors.forename: F
authors.initials: F
authors.lastname: Meissner
authors.forename: D
authors.initials: D
authors.lastname: Ropers
authors.forename: K
authors.initials: K
authors.lastname: Pohle
authors.forename: M
authors.initials: M
authors.lastname: Kusus
authors.forename: G
authors.initials: G
authors.lastname: Muschiol
authors.forename: W G
authors.initials: WG
authors.lastname: Daniel
authors.forename: W
authors.initials: W
authors.lastname: Moshage
mesh_terms: D000368:Aged; D002114:Calcinosis / Q000000981:diagnostic imaging* / Q000473:pathology; D009202:Cardiomyopathies / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods* / Q000592:standards