title: Influences of gender and weight gain on short-term relapse to smoking in a cessation trial.
abstract: Few researchers have studied whether weight gain has an impact on short-term relapse to smoking. The authors of this study investigated predictors of relapse among 989 participants (60% women) in a randomized, double-blind, 10-week multicenter trial to determine the effect of fluoxetine (30 or 60 mg) versus placebo in combination with behavioral counseling for smoking cessation. Medication compliance and smoking status were biochemically verified. At Visit 2, participants were asked to set a quit date within the subsequent 2 visits. A proportional hazards regression model was used to predict risk of relapse within the first 3 months of quitting. Weight gain predicted relapse, but for men only. Female gender also predicted relapse. The results led the authors to question whether postcessation weight gain interventions should be restricted to women smokers.
authors.affiliation: Center for Behavioral and Preventive Medicine, Brown University School of Medicine, Miriam Hospital, Providence, Rhode Island 02903, USA. Belinda_Borrelli@brown.edu
authors.forename: B
authors.initials: B
authors.lastname: Borrelli
authors.forename: B
authors.initials: B
authors.lastname: Spring
authors.forename: R
authors.initials: R
authors.lastname: Niaura
authors.forename: B
authors.initials: B
authors.lastname: Hitsman
authors.forename: G
authors.initials: G
authors.lastname: Papandonatos
mesh_terms: D000328:Adult; D015928:Cognitive Behavioral Therapy; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005473:Fluoxetine / Q000008:administration & dosage* / Q000009:adverse effects; D005783:Gender Identity; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D016540:Smoking Cessation / Q000523:psychology*; D016896:Treatment Outcome; D015430:Weight Gain
chemical_list: D005473:Fluoxetine