[Alcoholic and non-alcoholic fatty liver hepatitis. When is abstaining from alcohol enough, when do steroids help?].
Alcoholic and non-alcoholic steatohepatitis (NASH) are often histopathologically indistinguishable. Apart from the clinical and laboratory findings, the patient's history is of key importance for differentiating between alcoholic steatohepatitis with its poor prognosis, and NASH, with its usually bland course. While the latter rarely requires specific treatment, the former, in particular in its severe form, is a therapeutic challenge. In addition to suitable dietary measures, patients with a Maddrey Score > 32, may need corticosteroids. In patients with mild to moderate steatohepatitis, the daily alcohol consumption appears to be decisive for the prognosis. In severe forms of this condition, in contrast, mortality is high, and patients surviving the acute phase often develop cirrhosis, irrespective of their further drinking habits.
Berghaus
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TM
Medizinische Klinik II, Klinikum Grosshadern der Ludwig-Maximilians-Universität München. Thomas.Berghaus@med2.med.uni-muenchen.de
Beuers
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D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000437:Alcoholism / Q000473:pathology / Q000534:rehabilitation*; D005234:Fatty Liver / Q000209:etiology / Q000473:pathology / Q000534:rehabilitation*; D005235:Fatty Liver, Alcoholic / Q000473:pathology / Q000534:rehabilitation*; D006801:Humans; D008099:Liver / Q000473:pathology; D009765:Obesity / Q000150:complications; D012307:Risk Factors; D015431:Weight Loss
D000305:Adrenal Cortex Hormones