title: [Prevention of altitude decompression sickness during simulation of egress from the cabin of space vehicle with hypobaric artificial atmosphere].
abstract: Based on the proposed semiempiric nomograms, the study was aimed at selection and investigation of normoxic N2-O2 hypobaric atmosphere (HA) at 93-73 kPa, and evaluation of effectiveness of the gas mixture against the altitude decompression sickness (ADS) during 6-hr simulation of extravehicular activities at 37 kPa without prebreathing. Subjects were 22 healthy males from 20 to 50 yr. old. In all, 115 experiments were performed. Twenty-four hours in HA at 93 kPa and subsequent transition to 37 kPa led up to development of ADS symptoms by one subject in one of 27 experiments (3.7%), and emergence of venous gas bubbles (USI) with the intensity of 2, 70, and 19 points by the Spenser scale in 9 experiments (33.3%). Lower HA pressures (86 kPa, 80 kPa and 73 kPa) did not give rise to ADS though the occurrence of venous GB distinctly tended downward (30.6%, 14.3% and 11.8%) and so did the intensity of their entry into the pulmonary circulation (2, 40, 18 points; 1, 80, 19 points, and 2, 00, 15 points, respectively). Minimal ADS risk was observed in HA at 80 kPa and 73 kPa and did not reach 4% at the confidence level of 95%.
authors.affiliation: Aviakosmicheskaya i Ekologicheskaya Meditsina, Russia.
authors.forename: V I
authors.initials: VI
authors.lastname: Chadov
authors.forename: V P
authors.initials: VP
authors.lastname: Katuntsev
authors.forename: G F
authors.initials: GF
authors.lastname: Vorob'ev
authors.forename: L R
authors.initials: LR
authors.lastname: Iseev
authors.forename: V N
authors.initials: VN
authors.lastname: Poliakov
authors.forename: S N
authors.initials: SN
authors.lastname: Filipenkov
authors.forename: M A
authors.initials: MA
authors.lastname: Skedina
authors.forename: R T
authors.initials: RT
authors.lastname: Kazakova
mesh_terms: D000328:Adult; D000532:Altitude Sickness / Q000150:complications / Q000517:prevention & control*; D003665:Decompression Sickness / Q000150:complications / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D018561:Space Simulation; D018531:Spacecraft; D018474:Weightlessness Simulation