[The biological effect of matrix metalloproteinase-1 in epidermal repair].
OBJECTIVE
To review the role of matrix metalloproteinase-1 (MMP-1) in the course of healing in wounded skin.


METHODS
The recent literatures on MMP-1 in skin wound repair were reviewed, which gave the insight into the local effect of MMP-1 during re-epithelialization.


RESULTS
Following injury, basal keratinocytes, moving from the wound edge and interact with dermal matrix proteins in the wound bed, were induced to express MMP-1 in a specific space-time pattern. MMP-1 cleaved the collagen, thereby altering its structure and affinity by which the keratinocytes binded it. MMP-1 served a beneficial role in wound healing by facilitating the proliferation and movement of keratinocytes over the collagen-rich wound bed during re-epithelialization.


CONCLUSIONS
MMP-1 expression of migrating keratinocytes directly influences the re-epithelialization during the course of healing of the wounded skin.
Hu
D H
DH
Department of Burns, Xijing Hospital, Fourth Military Medical University, Xi'an Shanxi, P. R. China 710032. hudahai@fmmu.edu.cn
Chen
B
B
D003094:Collagen / Q000378:metabolism; D006801:Humans; D015603:Keratinocytes / Q000378:metabolism; D020781:Matrix Metalloproteinase 1 / Q000096:biosynthesis* / Q000502:physiology; D014945:Wound Healing / Q000502:physiology*
D003094:Collagen; D020781:Matrix Metalloproteinase 1