title: Phagocytized apoptotic cells in subcutaneous panniculitis-like T-cell lymphoma.
abstract: We reported on a case of subcutaneous panniculitis-like T-cell lymphoma (SPTCL) with multiple erythematous nodular lesions on the extremities, trunk and face. Histological examination of an excised lesion revealed a dense infiltrate of markedly atypical T-lymphoid cells expressing the CD8+ phenotype located in the subcutaneous tissue with histiocyte-phagocytizing apoptotic cells. The 'bean-bag' histiocytic cells, the characteristic finding of SPTCL, are considered to be products of haemophagocytosis. In our case the 'bean-bag' cells were produced by phagocytosis of apoptotic bodies, as confirmed by electron microscopy. It is suspected that 'bean-bag' cells are related not to haemophagocytosis but to phagocytosis of apoptotic cells in the CD8+ T-cell type of SPTCL.
authors.affiliation: Department of Dermatology, Surugadai Nihon University Hospital, Tokyo, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Ikeda
authors.forename: M
authors.initials: M
authors.lastname: Endo
authors.forename: S
authors.initials: S
authors.lastname: Uchigasaki
authors.forename: S
authors.initials: S
authors.lastname: Baba
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: N
authors.initials: N
authors.lastname: Kinukawa
authors.forename: N
authors.initials: N
authors.lastname: Nemoto
mesh_terms: D000328:Adult; D017209:Apoptosis; D001707:Biopsy, Needle; D005500:Follow-Up Studies; D006801:Humans; D016410:Lymphoma, T-Cell, Cutaneous / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D015434:Panniculitis / Q000188:drug therapy / Q000473:pathology*; D010587:Phagocytosis; D011239:Prednisolone / Q000008:administration & dosage; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D011239:Prednisolone