title: Affected sib-pair analysis in endometriosis.
abstract: This paper (i) reviews the current clinical and molecular genetic data which strongly suggest that endometriosis has a genetic basis; (ii) outlines the general principles of affected-sib pair analysis; and (iii) describes the Oxford Endometriosis Gene (OXEGENE) Study which aims, using a positional cloning approach, to identify susceptibility genes involved in the development of the disease.
authors.affiliation: Nuffield Department of Obstetrics and Gynaecology, University of Oxford, UK. skennedy@molbiol.ox.ac.uk
authors.forename: S
authors.initials: S
authors.lastname: Kennedy
authors.forename: S
authors.initials: S
authors.lastname: Bennett
authors.forename: D E
authors.initials: DE
authors.lastname: Weeks
mesh_terms: D000328:Adult; D002874:Chromosome Mapping; D004715:Endometriosis / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D005982:Glutathione Transferase / Q000235:genetics; D006801:Humans; D020412:Multifactorial Inheritance / Q000235:genetics; D009679:Nuclear Family; D010375:Pedigree; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase / Q000235:genetics
chemical_list: D005982:Glutathione Transferase; D006599:UDPglucose-Hexose-1-Phosphate Uridylyltransferase