title: Correlation of total and specific serum immunoglobulin E levels with the severity of chronic sinusitis in children.
abstract: Chronic sinusitis is frequently associated with allergy and asthma. Previous studies have shown that serum immunoglobulin E (IgE) levels correlate with allergy and asthma in adults. Because the role of allergic inflammation in the severity of chronic sinusitis remains controversial in children, we set out to determine whether a correlation exists between serum levels of total and specific IgE and the severity of chronic sinusitis in children. Forty-four children with chronic sinusitis were enrolled in the study. Computed tomographic scans were reviewed and scored for the severity of sinusitis. All children were mite-sensitive. Serum samples were assayed for total IgE and specific IgE antibodies to mite allergen using a fluoroimmunoassay. Fourteen subjects had extensive sinus disease. There was no significant difference in the average of total and specific IgE between the subjects with extensive and limited disease (p = 0.562 and 0.755, respectively). Thirty-four subjects were diagnosed with asthma. The subjects with extensive sinus disease had a higher prevalence of moderate to severe asthma than the subjects with limited disease (p = 0.006), but there was no significant difference in the average of total and specific IgE between the subjects with different severities of asthma. (p = 0.833 and 0.425, respectively). The data suggests that levels of total or specific IgE do not correlate with severity of chronic sinusitis in children. Nonetheless, the severity of chronic sinusitis and asthma correlate well with each other irrespective of total and specific IgE.
authors.affiliation: Department of Pediatrics, Chang Gung Children's Hospital and Chang Gung University, Taoyuan, Taiwan.
authors.forename: Y L
authors.initials: YL
authors.lastname: Lin
authors.forename: J L
authors.initials: JL
authors.lastname: Huang
authors.forename: L C
authors.initials: LC
authors.lastname: Chen
authors.forename: C R
authors.initials: CR
authors.lastname: Wang
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000918:Antibody Specificity / Q000276:immunology*; D001798:Blood Proteins / Q000032:analysis / Q000276:immunology; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D002908:Chronic Disease; D047091:Eosinophil Granule Proteins; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood* / Q000276:immunology*; D008297:Male; D015995:Prevalence; D012189:Retrospective Studies; D012260:Ribonucleases; D012720:Severity of Illness Index; D012852:Sinusitis / Q000097:blood* / Q000453:epidemiology* / Q000276:immunology*; D013223:Statistics as Topic; D013624:Taiwan / Q000453:epidemiology
chemical_list: D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D007073:Immunoglobulin E; D012260:Ribonucleases