title: [Structure determination of new antifungal antibiotics, polaramycins A and B].
abstract: Antifungal antibiotics, polaramycins A and B have been isolated from the culture of Streptomyces hygroscopicus LP-93. Polaramycins A and B are 36-membered polyol macrolide antibiotics containing hemiacetal monoester of malonic acid and guanidyl groups. Based on spectral evidence including UV, IR, FABMS, 1HNMR, 13CNMR, DEPT, 1H-1H COSY, HETCOR, HMBC, the structure of polaramycins A and B have been assigned as shown in Fig 1 (A, R = H; B, R = CH3).
authors.affiliation: Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
authors.forename: W
authors.initials: W
authors.lastname: Meng
authors.forename: W Z
authors.initials: WZ
authors.lastname: Jin
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D018942:Macrolides; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C438030:polaramycin A; C438031:polaramycin B