The glucose-regulated proteins: stress induction and clinical applications.
A protective mechanism used by cells to adapt to stress of the endoplasmic reticulum (ER) is the induction of members of the glucose-regulated protein (Grp) family. The induction of mammalian Grp proteins in response to ER stress involves a complex network of regulators and novel mechanisms. The elucidation of Grp function and regulation opens up new therapeutic approaches to diseases associated with ER stress and cancer.
Lee
A S
AS
University of Southern California/Norris Comprehensive Cancer Center, Dept of Biochemistry and Molecular Biology, University of Southern California Keck School of Medicine, 1441 Eastlake Avenue, Los Angeles, CA 90089-9176, USA. amylee@hsc.usc.edu
D000818:Animals; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D018840:HSP70 Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007167:Immunotherapy; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism / Q000628:therapy; D018384:Oxidative Stress; D011401:Promoter Regions, Genetic; D014158:Transcription, Genetic
D018840:HSP70 Heat-Shock Proteins; D008565:Membrane Proteins; C018551:glucose-regulated proteins