Multifunctional alpha-enolase: its role in diseases.
Enolase, a key glycolytic enzyme, belongs to a novel class of surface proteins which do not possess classical machinery for surface transport, yet through an unknown mechanism are transported on the cell surface. Enolase is a multifunctional protein, and its ability to serve as a plasminogen receptor on the surface of a variety of hematopoetic, epithelial and endothelial cells suggests that it may play an important role in the intravascular and pericellular fibrinolytic system. Its role in systemic and invasive autoimmune disorders was recognized only very recently. In addition to this property, its ability to function as a heat-shock protein and to bind cytoskeletal and chromatin structures indicate that enolase may play a crucial role in transcription and a variety of pathophysiological processes.
Pancholi
V
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Laboratory of Bacterial Pathogenesis and Immunology, The Rockefeller University, New York, NewYork 10021, USA. panchov@rockvax.rockefeller.edu
D000595:Amino Acid Sequence; D000818:Animals; D004194:Disease; D006801:Humans; D008969:Molecular Sequence Data; D010751:Phosphopyruvate Hydratase / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D010751:Phosphopyruvate Hydratase