Comparing benefits and risks of immunization.
BACKGROUND
This paper uses a straightforward method of quantifying the benefits and risks of immunization, illustrated by universal immunization programs in British Columbia against invasive Haemophilus influenzae type b disease (Hib), measles, rubella, and paralytic poliomyelitis.


METHODS
Data were extracted from provincial communicable disease and vaccine adverse event surveillance systems. Average disease incidence was compared before and after implementing universal immunization programs. Estimates of prevented deaths and serious disease complications were calculated and compared with expected numbers of serious vaccine-associated adverse events (VAAEs).


RESULTS
Average incidence of reported cases decreased 90 to 100% over a 5-year period after implementing universal programs. These benefits were sustained or strengthened over time. Rates of reported serious VAAEs were low.


CONCLUSIONS
The remarkable success of immunization has created a paradox. Despite a low absolute risk of serious VAAEs, the relative risk of some VAAEs can exceed risk of disease in the province.
Bigham
M
M
BC Centre for Disease Control, 655 W 12th Avenue, Vancouver, BC V5Z 4R4. mark.bigham@bccdc.hnet.bc.ca
Hoefer
M
M
D001955:British Columbia; D002648:Child; D002675:Child, Preschool; D019741:Haemophilus influenzae type b / Q000821:virology; D006801:Humans; D017589:Immunization Programs; D015994:Incidence; D008457:Measles / Q000453:epidemiology / Q000517:prevention & control*; D008583:Meningitis, Haemophilus / Q000453:epidemiology / Q000517:prevention & control*; D011051:Poliomyelitis / Q000453:epidemiology / Q000517:prevention & control*; D012306:Risk; D012409:Rubella / Q000453:epidemiology / Q000517:prevention & control*; D014612:Vaccines / Q000009:adverse effects* / Q000627:therapeutic use*
D014612:Vaccines