Mealtime glucose regulation in type 2 diabetes.
Glucose control remains the cornerstone of therapeutic strategies designed to reduce the risk of long-term complications in patients with type 2 diabetes. This article reviews a growing body of evidence suggesting that post-mealtime glucose spikes may exert an independent effect on diabetic complications, and discusses how a more effective strategy requires better focus on the regulation of mealtime glucose. New treatment options, specifically designed to restore a more physiological post-mealtime insulin profile, may provide better tools to ensure more comprehensive glycaemic control, which will allow for better prevention of micro- and macrovascular complications in type 2 diabetic patients.
Tuomilehto
J
J
Department of Epidemiology and Health Promotion, Diabetes and Genetic Epidemiology Unit, National Public Health Institute, Mannerheimintie 166, FIN-003000 Helsinki, Finland.
Del Prato
S
S
D000208:Acute Disease; D001786:Blood Glucose / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy / Q000378:metabolism*; D003928:Diabetic Nephropathies / Q000209:etiology / Q000517:prevention & control; D003929:Diabetic Neuropathies / Q000209:etiology / Q000517:prevention & control; D003930:Diabetic Retinopathy / Q000209:etiology / Q000517:prevention & control; D004040:Dietary Carbohydrates / Q000378:metabolism; D004435:Eating; D006801:Humans; D006943:Hyperglycemia / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000008:administration & dosage; D007328:Insulin / Q000008:administration & dosage; D019518:Postprandial Period
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D007004:Hypoglycemic Agents; D007328:Insulin