title: Ovine scrapie: priorities and importance.
abstract: Ovine and caprine scrapie occupies a unique place among animal transmissive spongiform encephalopathies (TSE). It is an object of intensive biomedicinal, ecological and economical studies. Its causative agents are demonstrably associated with the development of TSE in farmed minks, goats and moufflons. Ovine strains of scrapie occurring in North America (particularly in the USA) differ from strains which occur in Europe and were present at the onset of development of TSE in three species of deer living in free nature and in captivity in the USA. The studies dealing with the development of bovine spongiform encephalopathy (BSE) of the English type have indicated justifiably that its origin is associated with one (or more) heretofore unidentified ovine strain. The development of a variant form, the Creutzfeldt-Jacob disease in humans, and transmission of the BSE agent to several families of bovidae, felidae and primates, puts stress on its zoonotic potential. All this leads to the conclusion that domesticated sheep are the decisive reservoir species of animal TSE. They have been infected to an unknown extent with the causative agent of BSE probably through contaminated meat-bone meal. The occurrence of natural ovine prion isolates with properties similar to those of the BSE agent requires that scrapie should be included in the surveillance of human and animal TSE. At present, scrapie is a noticeable disease also in other than European Communities Member States. It is on the list B of the International Epizootics Office. Many countries have initiated control of ovine scrapie. It should therefore become a topical question also in Central and Eastern European countries. Elimination or even eradication of ovine scrapie (or its causative agents) from populations of small and large domestic ruminants is the prerequisite for prevention of penetration of ovine pathogenic prions into the human feed chain. Moreover, it should be ensured that these species will be able to produce foods of a new type (immunotrition and similar) or proteins with therapeutic effects in the near future. Our study established that the PrP genotype of Valachian rams, the Slovak autochthonous breed, contains also VRQ and ARQ alleles encoding the susceptibility to scrapie. Their selection is part of the improvement of Slovak Valachian sheep towards resistance to scrapie.
authors.affiliation: Neuroimunological Institute, Slovak Academy of Sciences, 842 46 Bratislava, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Novák
authors.forename: O J
authors.initials: OJ
authors.lastname: Vrtiak
authors.forename: I
authors.initials: I
authors.lastname: Mikula
authors.forename: L
authors.initials: L
authors.lastname: Tkáciková
mesh_terms: D000483:Alleles; D000818:Animals; D014644:Genetic Variation; D017096:Prion Diseases / Q000209:etiology / Q000235:genetics / Q000635:transmission / Q000662:veterinary; D011328:Prions / Q000235:genetics; D012608:Scrapie / Q000209:etiology* / Q000235:genetics / Q000635:transmission; D012756:Sheep; D013045:Species Specificity; D015047:Zoonoses / Q000209:etiology / Q000635:transmission
chemical_list: D011328:Prions