title: Effect of Carmeda BioActive Surface coating versus Trillium Biopassive Surface coating of the oxygenator on circulating platelet count drop during cardiopulmonary bypass.
abstract: An investigation was conducted to evaluate the effect that surface coating of the hollow-fiber membrane oxygenator had on circulating platelet count drop during cardiopulmonary bypass (CPB). Sixty patients undergoing non-emergency myocardial revascularization for coronary artery disease were randomly divided into two groups. Group one (n = 32) received the Carmeda-coated Maxima-Plus PRF oxygenator while the patients in Group two (n=28) received the Trillium-coated Affinity oxygenator during CPB. The net platelet count drops for the pump specimen (15-20 min after the initiation of bypass) for the Carmeda and the Trillium groups were 3.6 +/- 15.8% and 6.2 +/- 10.2%, respectively. The net platelet count drop for the warming specimen for the Carmeda and the Trillium groups were 2.9 +/- 19.4% and 0.5 +/- 11.0%, respectively. There were no statistically significant differences between the groups. The authors conclude that using either the Carmeda-coated Maxima-Plus PRF oxygenator or the Trillium-coated Affinity oxygenator afford similar benefits in regards to preserving circulating platelet counts during bypass.
authors.affiliation: Department of Perfusion, Lehigh Valley Hospital, Allentown, Pennsylvania 18105, USA. dpalanzo@enter.net
authors.forename: D A
authors.initials: DA
authors.lastname: Palanzo
authors.forename: D L
authors.initials: DL
authors.lastname: Zarro
authors.forename: N J
authors.initials: NJ
authors.lastname: Manley
authors.forename: R M
authors.initials: RM
authors.lastname: Montesano
authors.forename: M
authors.initials: M
authors.lastname: Quinn
authors.forename: B A
authors.initials: BA
authors.lastname: Elmore
authors.forename: P A
authors.initials: PA
authors.lastname: Gustafson
authors.forename: J M
authors.initials: JM
authors.lastname: Castagna
mesh_terms: D000368:Aged; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology* / Q000592:standards; D005260:Female; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010107:Oxygenators, Membrane; D010976:Platelet Count; D011108:Polymers / Q000494:pharmacology; D013499:Surface Properties
chemical_list: D020099:Coated Materials, Biocompatible; D011108:Polymers; D006493:Heparin