Zebrafish mutants: behavioral genetic studies of visual system defects.
Zebrafish are a promising model for behavioral and genetic studies of vertebrate visual system development and retinal degeneration. In the past few years, numerous studies on zebrafish vision have been published. While most of the studies focus on the molecular and cellular characterization of mutations that disrupt zebrafish visual system structure in early development, others examine the mechanisms that underlie inherited visual system disorders in adults. Behavioral assays, along with morphologic and electrophysiological methods, are powerful tools for functional analyses of zebrafish visual development and performance.
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Departments of Physiology and Ophthalmology, University of Kentucky College of Medicine, Lexington, Kentucky 40536, USA. leili@pop.uky.edu
D000818:Animals; D001519:Behavior; D008954:Models, Biological; D009154:Mutation; D009799:Ocular Physiological Phenomena; D014785:Vision, Ocular / Q000235:genetics* / Q000502:physiology*; D015027:Zebrafish