title: Assay of sertraline in tablets and drug substance by liquid chromatography.
abstract: A high-performance liquid chromatography isocratic procedure was developed for the assay of sertraline in drug substance and tablets. The chromatographic system consists of a RP-8 column (125 x 4 mm, 5 microm), a mobile phase composed of acetonitrile and sodium phosphate buffer, pH 5.5 (7:3), flow rate of 1.0 ml.min(-1) and UV detection at 270 nm. The method validation yielded good results. The coefficient of variation varied between 0.19 and 1.04% and accuracy of 99.18% was found. Calibration curve was linear between 0.5 and 2.5 mg x ml(-1); its correlation coefficient was 0.9999.
authors.affiliation: Curso de Pós-Graduação em Ciências Farmacêuticas, UFRGS, Av. Ipiranga, 2752, CEP 90610-000, Porto Alegre, Brazil.
authors.forename: A I
authors.initials: AI
authors.lastname: Adams
authors.forename: A M
authors.initials: AM
authors.lastname: Bergold
mesh_terms: D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D017367:Selective Serotonin Reuptake Inhibitors / Q000032:analysis*; D020280:Sertraline / Q000032:analysis*; D013607:Tablets
chemical_list: D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline; D013607:Tablets