Greasing the wheels of secretory transport.
Ever since George Palade's pioneering studies of zymogen secretion from pancreatic acinar cells, the underlying molecular mechanisms of vesicle-mediated protein transport have captivated cell biologists and biochemists. A watershed meeting on "Phosphoinositides and the Golgi", held at the Fogarty International Center of the National Institutes of Health in Bethesda, Maryland (March 13-14, 2001), provided reinterpretation and striking new insights about the functions of this phospholipid class in intracellular protein trafficking.
Thorner
J W
JW
Division of Biochemistry and Molecular Biology of the Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202 USA. jeremy@socrates.berkeley.edu
D000818:Animals; D012634:Bodily Secretions / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000235:genetics / Q000378:metabolism* / Q000648:ultrastructure; D006801:Humans; D010716:Phosphatidylinositols / Q000235:genetics / Q000378:metabolism*; D017434:Protein Structure, Tertiary / Q000235:genetics; D021381:Protein Transport / Q000235:genetics*; D022142:Secretory Vesicles / Q000378:metabolism* / Q000648:ultrastructure
D010716:Phosphatidylinositols