title: [Clinical application of cyclooxygenase-2 inhibitors].
abstract: Nonsteroidal antiinflammatory drugs (NSAIDs) are a group of compounds with similar therapeutic and side effects. Their therapeutic effects depend on blockade of prostaglandin synthesis through enzyme cyclooxygenase (COX) inhibition. Two isoforms of the enzyme cyclooxygenase have been identified: COX-1 and COX-2. Selective COX-2 inhibitors i.e. meloxicam, nimesulid, etodolac or highly selective COX-2 inhibitors i.e. celecoxib, rofecoxib have antiinflammatory and analgesic properties with less or no gastrointestinal or other NSAIDs-typical adverse effects. Highly selective COX-2 inhibitors may also be active in colonic polyposis, colorectal cancer and Alzheimer's disease.
authors.affiliation: Zakład Farmakologii Akademii Medycznej w łodzi.
authors.forename: M
authors.initials: M
authors.lastname: Dzielska-Olczak
authors.forename: S
authors.initials: S
authors.lastname: Olczak
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects / Q000494:pharmacology*; D003111:Colonic Polyps / Q000378:metabolism; D015179:Colorectal Neoplasms / Q000378:metabolism; D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000494:pharmacology*; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000378:metabolism; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases