[Expression of ras, p53, proliferating cell nuclear antigen in squamous cell carcinoma of maxillary sinus and their significance].
OBJECTIVE
To determine the expression of ras, p53 and proliferating cell nuclear antigen (PCNA) in squamous cell carcinoma(SCC), inverting papilloma(IP), inflammatory mucosa(IM) of maxillary sinus and analyze the correlation between their expression and the clinicopathological characters and prognosis of SCC of maxillary sinus(SCCMS).


METHODS
Expression of ras, p53 and PCNA was determined in 40 cases of SCC, 20 cases of IP and 10 cases of IM of maxillary sinus with immunohistochemical technique.


RESULTS
Expression of ras was correlated with differentiation of SCCMS, it was more frequent in well differentiated SCC than in poorly differentiated SCC. Expression of p53 was only present in SCCMS, there was not expression of p53 in IP and IM of maxillary sinus. The patients with high PCNA index SCCMS had a poorer prognosis than those with low PCNA index in SCCMS.


CONCLUSIONS
p53 protein may be a diagnostic marker in SCCMS. Measurement of PCNA index may be helpful in estimating prognosis and directing clinical treatment in SCCMS.
Zhu
D
D
EENT Hospital of Shanghai Medical University, Shanghai, 200031.
Wang
S
S
Wang
W
W
D000293:Adolescent; D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000235:genetics* / Q000473:pathology; D005260:Female; D015870:Gene Expression; D016158:Genes, p53; D011905:Genes, ras; D006801:Humans; D008297:Male; D008444:Maxillary Sinus Neoplasms / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009367:Neoplasm Staging; D018308:Papilloma, Inverted / Q000235:genetics; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000096:biosynthesis*
D018809:Proliferating Cell Nuclear Antigen