Effects of ageing on serotonin transporters in healthy females.
The effect of ageing on brain serotonin transporters was evaluated in 19 healthy female volunteers (age range 22-74 years) using single-photon emission tomography and [123I]nor-beta-CIT. The study subjects were scanned 0.3, 3, 6 and 23 h after injection of 185 MBq of [123I]nor-beta-CIT. The ratio of the distribution volume for tracer in the midbrain to that in the cerebellum minus 1 was used as an index for serotonin transporter binding. An age-related decline of 2% per decade (r=-0.47; P<0.05) was found in the midbrain. The decline in [123I]nor-beta-CIT binding in the serotonin transporter-rich area is much less than that in dopamine transporters in the striatum (6% per decade).
Kuikka
J T
JT
Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Finland. jkuikka@uku.fi
Tammela
L
L
Bergström
K A
KA
Karhunen
L
L
Uusitupa
M
M
Tiihonen
J
J
D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002352:Carrier Proteins / Q000032:analysis*; D002531:Cerebellum / Q000378:metabolism; D003042:Cocaine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins / Q000032:analysis*; D026901:Membrane Transport Proteins; D008636:Mesencephalon / Q000378:metabolism; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; D012016:Reference Values; D012701:Serotonin / Q000032:analysis*; D050486:Serotonin Plasma Membrane Transport Proteins; D012727:Sex Characteristics; D015899:Tomography, Emission-Computed, Single-Photon
D002352:Carrier Proteins; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D019275:Radiopharmaceuticals; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins; C086915:N-nor-3-(4'-iodophenyl)tropane-2-carboxylic acid methyl ester; D012701:Serotonin; D003042:Cocaine