title: Prevalence of vaginal colonization by drug-resistant Candida species in college-age women with previous exposure to over-the-counter azole antifungals.
abstract: We enrolled 382 college-age women in a cross-sectional survey to investigate the relationship between use of over-the-counter (OTC) azole-based antifungal drugs and vaginal colonization by drug-resistant Candida. This study showed no correlation (P=.506) between previous OTC exposure and colonization of drug-resistant Candida in vaginal flora. However, a small number of resistant Candida species isolates were obtained from women with a history of multiple exposures to OTC antifungals; given the widespread use of these products, this may be an emerging concern.
authors.affiliation: Public Health Research Institute, New York, NY, USA.
authors.forename: B
authors.initials: B
authors.lastname: Mathema
authors.forename: E
authors.initials: E
authors.lastname: Cross
authors.forename: E
authors.initials: E
authors.lastname: Dun
authors.forename: S
authors.initials: S
authors.lastname: Park
authors.forename: J
authors.initials: J
authors.lastname: Bedell
authors.forename: B
authors.initials: B
authors.lastname: Slade
authors.forename: M
authors.initials: M
authors.lastname: Williams
authors.forename: L
authors.initials: L
authors.lastname: Riley
authors.forename: V
authors.initials: V
authors.lastname: Chaturvedi
authors.forename: D S
authors.initials: DS
authors.lastname: Perlin
mesh_terms: D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001393:Azoles / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D004352:Drug Resistance, Microbial; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000627:therapeutic use; D015995:Prevalence; D013334:Students / Q000706:statistics & numerical data*; D014481:United States / Q000453:epidemiology
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D004366:Nonprescription Drugs; D015725:Fluconazole