title: Plasma and liver carnitine status of children with chronic liver disease and cirrhosis.
abstract: BACKGROUND
  Carnitine is an essential cofactor in the transfer of long-chain fatty acids across the inner mitochondrial membrane for oxidation. As its synthesis is performed in the liver, alterations in carnitine metabolism is expected in liver diseases, especially in cirrhosis.
  
  
  METHODS
  In this study, we investigated plasma and liver carnitine concentrations of 68 children with chronic liver disease, 36 of whom had cirrhosis as well. Carnitine level was determined by enzymatic method.
  
  
  RESULTS
  Plasma and liver carnitine concentrations were not correlated. Mean plasma carnitine level of cirrhotic children was significantly lower than that of the control group (P<0. 0001). While there was no difference between liver carnitine concentrations of children with chronic liver disease and cirrhosis (P>0.05), mean plasma level of cirrhotics were lower (P<0.05). Plasma carnitine was correlated with albumin, triglyceride and gamma glutamyl transpeptidase (GGT) in patients with chronic liver disease (P<0.05). Liver carnitine was correlated with GGT in cirrhotic patients (P<0.005). Children with malnutrition had higher plasma and liver carnitine levels (P<0.05). The highest plasma and liver carnitine levels were detected in children with biliary atresia and criptogenic cirrhosis, respectively. Both the lowest plasma and liver carnitine levels were detected in Wilson's disease.
  
  
  CONCLUSIONS
  Children with cirrhosis have low plasma carnitine concentrations. This finding is prominent in children with Wilson's disease. As carnitine is an essential factor in lipid metabolism, the carnitine supplementation for patients with cirrhosis in childhood, especially with Wilson's disease, seems to be mandatory.
authors.affiliation: Ege University, Department of Pediatric Gastroenterology and Nutrition, Izmir, Turkey. ayseselimoglu@hotmail.com
authors.forename: M A
authors.initials: MA
authors.lastname: Selimoglu
authors.forename: S
authors.initials: S
authors.lastname: Aydogdu
authors.forename: R V
authors.initials: RV
authors.lastname: Yagci
authors.forename: A
authors.initials: A
authors.lastname: Huseyinov
mesh_terms: D000293:Adolescent; D000328:Adult; D002331:Carnitine / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006527:Hepatolenticular Degeneration / Q000097:blood / Q000378:metabolism; D006801:Humans; D007223:Infant; D008099:Liver / Q000737:chemistry*; D008103:Liver Cirrhosis / Q000097:blood / Q000378:metabolism*; D008107:Liver Diseases / Q000097:blood / Q000378:metabolism*; D008297:Male
chemical_list: D002331:Carnitine