title: Plasmodium falciparum transmission intensity and infection rates in children in Gabon.
abstract: Several factors can determine the outcome of a malarial infection. Studies on susceptibility or resistance to malarial infection can be confounded by differences in transmission. In the present study, the relationship between vector abundance and Plasmodium falciparum infection rate of Gabonese children was studied. Indoor human bait catches were conducted in the houses of two groups of children, those who had been found earlier to be either frequently (> 3 infections per year) or rarely (< 0.5 infections per year) infected with P. falciparum. The human biting rate was 12 and 31 bites per person per night during the dry and the rainy season, with 3% and 16% Anopheles, respectively. Anopheles gambiae and A. moucheti were found to be the only vectors involved in the transmission of malaria in this area. No significant difference in the abundance and the rate of P. falciparum infection of the Anopheles mosquitoes was found among children rarely or frequently infected. Differences in transmission cannot account for differences in infection rates in our study group. Hereditary and immunological factors seem to be the primary determinants for the outcome of malarial infection.
authors.affiliation: Laboratoire de Recherche, Hĵpital Albert Schweitzer, Lambaréné, Gabon.
authors.forename: E H
authors.initials: EH
authors.lastname: Sylla
authors.forename: B
authors.initials: B
authors.lastname: Lell
authors.forename: J F
authors.initials: JF
authors.lastname: Kun
authors.forename: P G
authors.initials: PG
authors.lastname: Kremsner
mesh_terms: D000818:Animals; D000852:Anopheles / Q000145:classification / Q000469:parasitology*; D002648:Child; D002675:Child, Preschool; D017931:DNA Primers / Q000737:chemistry; D016054:DNA, Protozoan / Q000032:analysis; D004199:Disease Vectors; D005681:Gabon / Q000453:epidemiology; D006801:Humans; D007299:Insect Bites and Stings; D007303:Insect Vectors / Q000469:parasitology* / Q000502:physiology; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000635:transmission*; D010963:Plasmodium falciparum / Q000235:genetics / Q000302:isolation & purification*; D016133:Polymerase Chain Reaction; D012621:Seasons
chemical_list: D017931:DNA Primers; D016054:DNA, Protozoan