title: The role of rat dorsomedial prefrontal cortex in working memory for egocentric responses.
abstract: The present experiment studied the effects of quinolinic acid (90 mM) lesions of the medial precentral and anterior cingulate on working memory for egocentric responses. Rats were trained on a delayed match-to-sample task that involved memory for a 90 degrees right or left turn. The results indicated that lesioned rats had significantly decreased scores during the 10 s delay condition compared to presurgery levels. An increase in the delay to 20 s significantly reduced working memory performance in the lesioned rats compared to that of controls. These findings suggest that the rat medial precentral and/or anterior cingulate area play an important role in working memory for egocentric responses.
authors.affiliation: Department of Psychology, University of Illinois at Chicago, 1007 W. Harrison Street, 60607, Chicago, IL, USA. mrago@uic.edu
authors.forename: M E
authors.initials: ME
authors.lastname: Ragozzino
authors.forename: R P
authors.initials: RP
authors.lastname: Kesner
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology; D003714:Denervation; D006179:Gyrus Cinguli / Q000502:physiology; D008297:Male; D018782:Maze Learning / Q000502:physiology*; D008570:Memory, Short-Term / Q000502:physiology*; D017397:Prefrontal Cortex / Q000502:physiology*; D017378:Quinolinic Acid; D051381:Rats; D020318:Rats, Long-Evans; D013037:Spatial Behavior / Q000502:physiology
chemical_list: D017378:Quinolinic Acid