title: Aurintricarboxylic acid decreases proliferative potential of SKOV3 and MCF7 human carcinoma cells.
abstract: The effect of aurintricarboxylic acid (ATA) on cell growth and proliferative capacity was studied in human ovarian SKOV3 and breast MCF7 carcinoma cells. ATA moderately inhibited cell growth measured by a Neutral red assay after a 24-hour incubation of the cells in the presence of ATA. The ATA-treated cells displayed a markedly decreased capacity to proliferate, as was evident from a colony formation assay. The initial and delayed anti-proliferative effects of ATA were dose-dependent. Together, the results indicated that ATA offers the potential of being recognized as an anti-tumor drug, at least in certain types of cancers.
authors.affiliation: Department of Clinical Pharmacology, Center for the Multidisciplinary Research in Aging, Ben-Gurion University of the Negev, Beer-Sheva, Israel. vadimfra@zahav.net.il
authors.forename: V
authors.initials: V
authors.lastname: Fraifeld
authors.forename: R
authors.initials: R
authors.lastname: Seidman
authors.forename: O
authors.initials: O
authors.lastname: Sagi
authors.forename: K
authors.initials: K
authors.lastname: Muradian
authors.forename: M
authors.initials: M
authors.lastname: Wolfson
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001312:Aurintricarboxylic Acid / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology*; D013997:Time Factors; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D001312:Aurintricarboxylic Acid