title: [Influence of ligustrazine-contained peritoneal dialysate on efficiency of dialysis].
abstract: OBJECTIVE
  To observe the influence of ligustrazine on efficiency of peritoneal dialysis.
  
  
  METHODS
  A prospective, self-controlled study was adopted, 24 stable continuous ambulatory peritoneal dialysis (CAPD) patients were divided into 4 groups according to their peritoneal membrane solute transport types identified by peritoneal equilibration test (PET), the high transport group (H group, 4 cases), the high-average transport group (Ha group, 11 cases), the low-average transport group (La group, 8 cases) and the low transport group (L group, 1 case). After treated with standard dialysis for 2 weeks, patients were treated by peritoneal dialysis with ligustrazine (240 mg/d) contained dialysate for another 2 weeks, and changes on mean net ultrafiltration volume (UF) per exchange, and urea kinetics (KT/V) per week of patients were observed.
  
  
  RESULTS
  After ligustrazine treatment, the UF and KT/V raised significantly, P < 0.01. In comparison of groups with different transportation, except change on UF of the H group was insignificant, increment of both parameters before and after treatment were significant (P < 0.01 or 0.05).
  
  
  CONCLUSIONS
  By adding ligustrazine in standard dialysate can enhance the efficiency of peritoneal dialysis, raise the UF, so is worth further study.
authors.affiliation: Institute of Kidney, First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou 510080.
authors.forename: C
authors.initials: C
authors.lastname: Lu
authors.forename: R
authors.initials: R
authors.lastname: Ye
authors.forename: L
authors.initials: L
authors.lastname: Sun
mesh_terms: D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D011446:Prospective Studies; D011719:Pyrazines / Q000627:therapeutic use*; D014462:Ultrafiltration
chemical_list: D011719:Pyrazines; C017953:tetramethylpyrazine