Immunohistochemical study of Muc1, Muc2 and human gastric mucin in breast carcinoma: relationship with prognostic factors.
We investigated the expression of mucin core proteins, Muc1, Muc2, and human gastric mucin (HGM) immunohistochemically in 5 non-invasive, 62 invasive ductal carcinomas and 3 mucinous carcinomas of the breast and statistically examined the relationship with prognostic factors. Muc1 was expressed in almost all breast carcinomas and there was a reverse correlation with tumor size (r = -0.25). However, Muc1 was not significantly correlated with the other tumor characteristics such as lymphocytic infiltration, axillary lymph node metastasis, TNM and plasma levels of CA153. Muc2 and HGM were expressed in 5 cases each in invasive ductal carcinomas, 0 and 3 in non-invasive ductal carcinomas, and 2 and 1 in mucinous carcinomas, respectively. Muc 2 expression correlated with lymph node metastasis. HGM was found in the tumors without lymph node metastasis and lower levels of serum CA153.
Xu
Y
Y
Department of Pathology, Tohoku Rosai Hospital, Sendai, Japan.
Kimura
N
N
Yoshida
R
R
Lin
H
H
Yoshinaga
K
K
D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000378:metabolism; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D005260:Female; D005752:Gastric Mucins / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008875:Middle Aged; D018396:Mucin-1 / Q000378:metabolism*; D055262:Mucin-2; D009077:Mucins / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D015996:Survival Rate
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D005752:Gastric Mucins; C524625:MUC2 protein, human; D018396:Mucin-1; D055262:Mucin-2; D009077:Mucins