[Genetic polymorphisms of cytochrome P450 1A1 and susceptibility of early-onset Parkinson's disease].
OBJECTIVE
To assess the possible association between the Msp I polymorphisms of cytochrome P450 1A1(CYP1A1) and the susceptibility of early-onset Parkinson's disease among Hans in the northern part of China.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) method was used to analyze three genotypes A, B and C in 3'flanking region of CYP1A1 in 126 patients with idiopathic early-onset Parkinson's disease and 172 healthy controls.


RESULTS
The frequencies of genotypes A, B and C in patients were 41.3%, 43.6% and 15.1% while those in the controls were 34.9%, 51.7% and 13.4%, respectively. No statistically significant difference in the frequencies of the three genotypes was observed between the two groups. The frequencies of two alleles were of no significant difference between the patients and controls.


CONCLUSIONS
The above results suggest that the Msp I polymorphisms of cytochrome P450 1A1 itself might not be associated with idiopathic early-onset Parkinson's disease.
Liu
P
P
Department of Neurology, Zhujiang Hospital, the First Military Medical University, Guangzhou, Guangdong 510282 P.R.China. dr-Liu@263.net
Liu
Z
Z
Shao
M
M
Chen
B
B
D000328:Adult; D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D002681:China; D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000235:genetics*; D011110:Polymorphism, Genetic; D055815:Young Adult
D019363:Cytochrome P-450 CYP1A1