title: Prunioside A: a new terpene glycoside from Spiraea prunifolia.
abstract: Prunioside A (1) has been isolated from an EtOAc-soluble extract of Spiraea prunifolia var. simpliciflora by a combination of chromatographic techniques. The structure was determined primarily by extensive NMR experiments. Compound 1 is a unique terpene glycoside. Its acetylated derivative (1a) inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells in a dose-dependent manner.
authors.affiliation: Professional Graduate School of Oriental Medicine, and Medicinal Resources Research Center, Wonkwang University, Iksan, Chonbuk 570-749, Republic of Korea.
authors.forename: H
authors.initials: H
authors.lastname: Oh
authors.forename: G S
authors.initials: GS
authors.lastname: Oh
authors.forename: W G
authors.initials: WG
authors.lastname: Seo
authors.forename: H O
authors.initials: HO
authors.lastname: Pae
authors.forename: K Y
authors.initials: KY
authors.lastname: Chai
authors.forename: T O
authors.initials: TO
authors.lastname: Kwon
authors.forename: Y H
authors.initials: YH
authors.lastname: Lee
authors.forename: H T
authors.initials: HT
authors.lastname: Chung
authors.forename: H S
authors.initials: HS
authors.lastname: Lee
mesh_terms: D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007723:Korea; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D009569:Nitric Oxide / Q000096:biosynthesis; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
chemical_list: D006027:Glycosides; D013729:Terpenes; C435863:prunioside A; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse