Energizing epithelial transport with the vacuolar H(+)-ATPase.
The Ussing model has long provided the conceptual foundation for understanding epithelial transport mechanisms energized by the Na(+)-K(+)-ATPase. Plasma membranes may also use the vacuolar (V-type) H(+)-ATPase as the primary energy source of membrane and epithelial transport. A pure electrogenic pump, the V-type H(+)-ATPase energizes not only membranes it inhabits but also other transport pathways via electrical coupling.
Beyenbach
K W
KW
Department of Biomedical Sciences, Cornell University, Ithaca, New York 14853, USA. kwb1@cornell.edu
D000818:Animals; D001692:Biological Transport / Q000502:physiology; D004848:Epithelium / Q000201:enzymology; D008317:Malpighian Tubules / Q000201:enzymology*; D006180:Proton-Translocating ATPases / Q000378:metabolism*; D014617:Vacuoles / Q000201:enzymology*
D006180:Proton-Translocating ATPases