title: Microcirculatory changes in right lobe grafts in living-donor liver transplantation: a near-infrared spectrometry study.
abstract: BACKGROUND
  A continuing shortage of cadaveric liver even for adult patients has motivated not a few centers to proceed to living-donor liver transplantation using right lobe grafts. One of controversies is potential congestion in the graft anterior segment by the deprivation of the middle hepatic vein.
  
  
  METHODS
  Hepatic tissue oxygenation and hemoglobin concentration were investigated with a near-infrared spectroscopy in the course of harvesting and implantation in living-donor liver transplantation. Twenty adult recipients of right lobe graft were involved in the study. The aim of the analysis was to detect tissue congestion or ischemia.
  
  
  RESULTS
  No significant change in mean hepatic tissue oxygenation and hemoglobin was noted in the right lobe during donor operation even after hepatic parenchymal transection, although some trend for relative congestion, i.e., increased tissue hemoglobin, compared with the left lobe was observed. After graft reperfusion in the recipient, both mean hepatic tissue oxygen saturation and hemoglobin decreased significantly in the anterior segment, which was accompanied by increased heterogeneity of tissue hemoglobin and oxygenation. Increased heterogeneity of oxygenation and decreased tissue hemoglobin were observed also in the posterior segment.
  
  
  CONCLUSIONS
  The anterior segment in right lobe living-donor liver transplantation is sensitive to ischemia, rather than congestion, at least in the immediate phase after graft reperfusion. The anterior segment seems to be also more prone to circulatory disturbance than the other part of the graft.
authors.affiliation: Department of Transplantation and Immunology, Kyoto University Faculty of Medicine, 54 Kawara-cho, Shogoin, Sakyo-ku Kyoto 606-8507, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Cui
authors.forename: T
authors.initials: T
authors.lastname: Kiuchi
authors.forename: H
authors.initials: H
authors.lastname: Egawa
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: S
authors.initials: S
authors.lastname: Sakamoto
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: S
authors.initials: S
authors.lastname: Kaihara
authors.forename: S
authors.initials: S
authors.lastname: Uemoto
authors.forename: Y
authors.initials: Y
authors.lastname: Inomata
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D001794:Blood Pressure; D005190:Family; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006498:Hepatectomy / Q000379:methods; D006801:Humans; D008102:Liver Circulation / Q000502:physiology*; D016031:Liver Transplantation / Q000502:physiology*; D019520:Living Donors; D008297:Male; D008833:Microcirculation / Q000502:physiology*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism; D013055:Spectrophotometry, Infrared / Q000379:methods; D020858:Tissue and Organ Harvesting / Q000379:methods
chemical_list: D006454:Hemoglobins; D010108:Oxyhemoglobins; D010100:Oxygen