[Langerin: a new lectin specific for Langerhans cells induces the formation of Birbeck granules].
Generation of monoclonal antibodies restricted to human dendritic cells generated from CD34+ hematopoietic precursors has enabled the identification of Langerin, a Ca(++)-dependent type II lectin. Only expressed by Langerhans cells, Langerin is responsible for Birbeck granule formation by membrane superimposition and zippering. Furthermore, cell-surface Langerin is rapidly internalized into Birbeck granules, and does not colocalize with MHC class II rich compartments. Langerin gene transfected into mouse fibroblasts induces the formation of Birbeck granule-like structures, that would permit a better understanding of the function of Birbeck granules.
Valladeau
J
J
Laboratoire de recherches immunologiques Schering-Plough, 69571 Dardilly, France.
Caux
C
C
Lebecque
S
S
Saeland
S
S
D000818:Animals; D015703:Antigens, CD; D000954:Antigens, Surface / Q000276:immunology*; D002118:Calcium / Q000502:physiology; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D003713:Dendritic Cells / Q000276:immunology*; D005347:Fibroblasts / Q000502:physiology / Q000648:ultrastructure; D006801:Humans; D007801:Langerhans Cells / Q000276:immunology* / Q000648:ultrastructure*; D037102:Lectins / Q000276:immunology*; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins; D051379:Mice; D014162:Transfection
D015703:Antigens, CD; D000954:Antigens, Surface; C121916:CD207 protein, human; C498497:Cd207 protein, mouse; D037102:Lectins; D037181:Lectins, C-Type; D037241:Mannose-Binding Lectins; D002118:Calcium