title: Awake respiratory function in patients with the obstructive sleep apnoea syndrome.
abstract: BACKGROUND
  The flow-volume curves of patients with obstructive sleep apnoea (OSA) obtained during the awake state are frequently abnormal.
  
  
  OBJECTIVE
  To determine 1) the relationship between the awake respiratory function and the severity of sleep-disordered breathing in a group of Malaysian patients with the OSA syndrome and 2) the frequency of flow-volume curve abnormality in these patients.
  
  
  METHODS
  A retrospective analysis of the data from respiratory function tests during wakefulness and nocturnal polysomnography was performed on 48 patients with OSA. The severity of OSA was defined by the apnoea-hypopnoea index (AHI) and the lowest oxygen saturation during sleep (SpO2nadir).
  
  
  RESULTS
  AHI had a significant relationship with alveolar-arterial oxygen gradient (r = 0.34, p = 0.046) and SpO2nadir (r = -0.49, p < 0.001) but not with any anthropometric parameter or the other awake respiratory function variables measured. SpO2nadir had a significant relationship with body mass index (r = -0.54, p < 0.001), neck circumference (r = -0.39, p = 0.013), awake room air PaO2 (r = 0.61, p < 0.001), alveolar-arterial oxygen gradient (r = -0.41, p = 0.015) and baseline supine SpO2 (r = 0.53, p < 0.001). There was no correlation between SpO2nadir and any spirometric or static lung volume parameters. The maximum inspiratory and maximum expiratory flow-volume curves of 26 patients (54%) showed a ratio of forced expiratory flow to forced inspiratory flow at mid-vital capacity (FEF50/FIF50) greater than one. In addition, flow oscillations (the "sawtooth" sign) were noted in the inspiratory and/or expiratory flow-volume curves of 21 patients (44%), 9 of whom did not have an FEF50/FIF50 > 1. Altogether, the maximum flow-volume curves during wakefulness of 35 (73%) of the 48 patients showed variable upper airway obstruction and/or flow oscillations. However, the presence of these two upper airway abnormalities, either occurring alone or together did not have an effect on the severity of OSA as measured by the AHI or SpO2nadir.
  
  
  CONCLUSIONS
  Abnormalities of the flow-volume loop consistent with inspiratory flow limitation and/or upper airway instability during wakefulness are common in patients with the OSA syndrome. The degree of oxygen desaturation during sleep in these patients is related to their awake oxygenation status.
authors.affiliation: Department of Medicine, University of Malaya Medical Centre, 50603 Kuala Lumpur.
authors.forename: C K
authors.initials: CK
authors.lastname: Liam
authors.forename: K H
authors.initials: KH
authors.lastname: Lim
authors.forename: C M
authors.initials: CM
authors.lastname: Wong
authors.forename: W M
authors.initials: WM
authors.lastname: Lau
authors.forename: C T
authors.initials: CT
authors.lastname: Tan
mesh_terms: D000328:Adult; D000368:Aged; D015992:Body Mass Index; D006801:Humans; D008875:Middle Aged; D009333:Neck / Q000033:anatomy & histology; D012119:Respiration; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000503:physiopathology*