title: Glucocorticoids affect gonadotropin-releasing hormone immunoreactivity in musk shrew brain.
abstract: Multiple interactions between the hypothalamic-pituitary-adrenal and the hypothalamic-pituitary-gonadal systems exist. In this study, we asked if glucocorticoid administration affected gonadotropin-releasing hormone (GnRH) immunoreactivity. We found that musk shrews treated with dexamethasone (DEX), a synthetic glucocorticoid, had more GnRH-immunoreactive (ir) cells in the forebrain than did cortisol- or control-treated animals. The effects of DEX were noted rapidly, within 15 min, after administration. These effects were observed in the forebrain as a whole and also in specific subpopulations of GnRH-ir cells located in the medial septum/diagonal band and the hypothalamus.
authors.affiliation: Department of Psychology, Wright State University, Dayton, Ohio 45435, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Schiml-Webb
authors.forename: J L
authors.initials: JL
authors.lastname: Temple
authors.forename: E F
authors.initials: EF
authors.lastname: Rissman
mesh_terms: D000818:Animals; D001921:Brain / Q000166:cytology / Q000187:drug effects*; D001923:Brain Chemistry; D002452:Cell Count; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis*; D006854:Hydrocortisone / Q000494:pharmacology; D007031:Hypothalamus / Q000737:chemistry / Q000166:cytology / Q000187:drug effects; D007150:Immunohistochemistry; D007700:Kinetics; D016548:Prosencephalon / Q000737:chemistry / Q000187:drug effects; D012688:Septum Pellucidum / Q000737:chemistry / Q000166:cytology / Q000187:drug effects; D012788:Shrews / Q000502:physiology*
chemical_list: D005938:Glucocorticoids; D007987:Gonadotropin-Releasing Hormone; D003907:Dexamethasone; D006854:Hydrocortisone