Effect of anxiolytics on blood sugar level in rabbits.
Anxiety disorders are more prevalent not only in normal individuals but also in diabetes mellitus. Diazepam, a benzodiazepine, and buspirone, an azaspirodecanedione, are the most often prescribed anxiolytics. Present study was aimed to investigate the effect of diazepam and buspirone on the blood sugar levels in rabbits. Buspirone (0.5 mg/kg/day p.o.) and diazepam (0.6 mg/kg/day p.o.) did not affect the glucose levels in rabbits even after one month of treatment. Present findings suggest that these two anxiolytics have minimal effect on blood sugar control.
Dixit
R K
RK
Department of Pharmacology, GSVM Medical College, Kanpur, India. medinst@pgi.chd.nic.in
Puri
J N
JN
Sharma
M K
MK
Jain
I P
IP
Singh
S
S
Ansari
N A
NA
Singh
S P
SP
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001008:Anxiety Disorders / Q000150:complications / Q000188:drug therapy; D001786:Blood Glucose / Q000378:metabolism*; D002065:Buspirone / Q000008:administration & dosage / Q000009:adverse effects; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood; D003975:Diazepam / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D011817:Rabbits
D014151:Anti-Anxiety Agents; D001786:Blood Glucose; D003975:Diazepam; D002065:Buspirone