title: Effect of high retinoid doses on RAR-beta mRNA expression in female B6D2F1 mice.
abstract: The expression of retinoid receptors is altered during the development of several types of cancer. In the present study, we determined the influence of high dietary concentrations of 4-hydroxyphenylretinamide (4-HPR) and 13-cis-retinoic acid (13-cis-RA) on RAR-beta mRNA expression in female mice. Expression of liver and lung RAR-beta RNA increased with increasing levels of dietary retinoid (both 4-HPR and 13-cis RA). Bladder RAR-beta mRNA levels, however, were significantly decreased in mice fed 13-cis RA or 4-HPR. These results suggest that feeding high levels of retinoids to mice results in tissue-specific elfects on expression of RAR-beta mRNA.
authors.affiliation: Department of Nutrition Sciences, The University of Alabama at Birmingham, 35294-3360, USA. garyj@uab.edu
authors.forename: G L
authors.initials: GL
authors.lastname: Johanning
authors.forename: M B
authors.initials: MB
authors.lastname: Cope
authors.forename: T
authors.initials: T
authors.lastname: Wilborn
authors.forename: C J
authors.initials: CJ
authors.lastname: Grubbs
authors.forename: R A
authors.initials: RA
authors.lastname: Lubet
mesh_terms: D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D015152:Blotting, Northern; D018076:DNA, Complementary / Q000378:metabolism; D005260:Female; D017313:Fenretinide / Q000494:pharmacology*; D015474:Isotretinoin / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051379:Mice; D012313:RNA / Q000378:metabolism; D012333:RNA, Messenger / Q000378:metabolism*; D018168:Receptors, Retinoic Acid / Q000096:biosynthesis*; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000378:metabolism
chemical_list: D016588:Anticarcinogenic Agents; D018076:DNA, Complementary; D012333:RNA, Messenger; D018168:Receptors, Retinoic Acid; C082925:retinoic acid receptor beta; D017313:Fenretinide; D012313:RNA; D015474:Isotretinoin