title: A case of an ameloblastic fibro-odontoma arising from a calcifying odontogenic cyst.
abstract: This case report describes an ameloblastic fibro-odontoma arising from a calcifying odontogenic cyst (COC) in the mandible of a twenty-three-year old male. The patient was referred to the Department of Oral Surgery, Tokyo Dental College, on March 30th, 2000, complaining of a painful swelling, which had appeared three weeks earlier on his left mandibular molar region. In a pathological view, the lesion was a round cyst the size of a chicken-egg, dark red in color, and surrounded by a thick membrane. The cyst had an epithelium of varying thickness which included many ghost cells and an enamel-like structure on the inside, and a thick wall of connective tissue with an ameloblastic fibro-odontoma on the outside. Enamel organ-like epithelial islands were structured radially in the form of strands with immature dentin. Cytokeratin 19 was strongly immunoreactive in the epithelium of the lesion; osteopontin and osteocalcin reacted in the mesenchymal cells and weakly in the epithelial element of this tumor.
authors.affiliation: Oral Health Science Center, Department of Pathology, Tokyo Dental College, Chiba, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuzaka
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Nashimoto
authors.forename: K
authors.initials: K
authors.lastname: Takemoto
authors.forename: H
authors.initials: H
authors.lastname: Ishikawa
authors.forename: M
authors.initials: M
authors.lastname: Asaka
authors.forename: M
authors.initials: M
authors.lastname: Shimono
authors.forename: M
authors.initials: M
authors.lastname: Fujikawa
authors.forename: H
authors.initials: H
authors.lastname: Noma
mesh_terms: D000328:Adult; D003238:Connective Tissue / Q000473:pathology; D003743:Dental Enamel / Q000473:pathology; D003804:Dentin / Q000473:pathology; D004658:Enamel Organ / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D006801:Humans; D007633:Keratins / Q000032:analysis; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology*; D008648:Mesoderm / Q000473:pathology; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D018333:Odontogenic Cyst, Calcifying / Q000473:pathology*; D009810:Odontoma / Q000473:pathology*; D015675:Osteocalcin / Q000032:analysis; D053495:Osteopontin; D010750:Phosphoproteins / Q000032:analysis; D012795:Sialoglycoproteins / Q000032:analysis
chemical_list: D010750:Phosphoproteins; C506895:SPP1 protein, human; D012795:Sialoglycoproteins; D015675:Osteocalcin; D053495:Osteopontin; D007633:Keratins