Metachromasia of the endocervical epithelium in women treated with gonadotropin releasing hormone agonist.
Endocervical epithelium from women treated with gonadotropin releasing hormone agonist (GnRH agonist) were compared with those from untreated women, using metachromatic stain with toluidine blue and immunohistochemistry, for estrogen and progesterone receptors. Smaller endocervical epithelium with lower intraepithelial mucus and more prominent nuclear distribution of estrogen receptors were seen in a woman who was treated for twelve months with GnRH agonists, as compared with those from an untreated premenopausal woman.
Morimura
M
M
Department of Obstetrics and Gynecology, Osaka City University Medical School, 1-4-3 Asahimachi, Abeno-ku, Osaka 545-8585, Japan.
Ishiko
O
O
Honda
K I
KI
Sumi
T
T
Kawamura
N
N
Wakasa
K
K
Haba
T
T
Ogita
S
S
D000328:Adult; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use; D002064:Buserelin / Q000627:therapeutic use; D002584:Cervix Uteri / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D007044:Hysterectomy; D007889:Leiomyoma / Q000188:drug therapy / Q000601:surgery; D016729:Leuprolide / Q000627:therapeutic use; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism; D013194:Staining and Labeling / Q000379:methods; D014048:Tolonium Chloride; D014594:Uterine Neoplasms / Q000188:drug therapy / Q000601:surgery
D018931:Antineoplastic Agents, Hormonal; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014048:Tolonium Chloride; D007987:Gonadotropin-Releasing Hormone; D016729:Leuprolide; D002064:Buserelin