Antiulcerogenic and analgesic effects of Maytenus aquifolium, Sorocea bomplandii and Zolernia ilicifolia.
Maytenus aquifolium (Celastraceae), Sorocea bomplandii (Moraceae) and Zolernia ilicifolia (Fabaceae) are native plants from the Tropical Atlantic Forest (Mata Atlântica, Brazil) known as "espinheira-santa". These plants are traditionally used as analgesic and antiulcerogenic medicine, with the same traditional uses of the true "espinheira-santa" (Maytenus ilicifolia, Celastraceae), an efficient antiulcerogenic agent. Pharmacological and toxicological studies with these plants have not been carried out. The purpose in this study was to evaluate the efficacy (analgesic and antiulcerogenic activities), safety (acute toxicity) and quality (phytochemical profile) of these three plants. The analgesic effect was analyzed by writhing and tail flick tests, while antiulcerogenic effect was performed through ulcer induction by ethanol and indomethacin/bethanecol assays. LD(50) and acute toxic effects, as well as phytochemical profiles of all plants also were carried. Surprisingly, the three plants showed analgesic and antiulcerogenic effects at dose of 1000 mg/kg, v.o. Maytenus aquifolium lowering all ulcerogenic parameters (ethanol test), but increased the ulcerogenic effects in the indomethacin/bethanecol test. Sorocea bomplandii produced antiulcerogenic effects in both experimental models used, while Zolernia ilicifolia showed significant effects only in indomethacin/bethanecol-induced gastric lesions. Pre-treatment with Zolernia ilicifolia induced someone toxic effects. A phytochemical profile for each plant species was determined and its main chemical classes of compounds were described.
Gonzalez
F G
FG
Laboratório de Fitofarmacos, Departamento de Farmacologia, Instituto de Biociências, Unesp. Botucatu, SP, CEP 18618-000, Brazil.
Portela
T Y
TY
Stipp
E J
EJ
Di Stasi
L C
LC
D000284:Administration, Oral; D000700:Analgesics / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001938:Brazil; D002927:Cimetidine / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin; D019684:Magnoliopsida / Q000737:chemistry*; D008297:Male; D008519:Medicine, Traditional; D051379:Mice; D008517:Phytotherapy; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D010946:Plants, Medicinal; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D023382:Toxicity Tests, Acute
D000700:Analgesics; D000897:Anti-Ulcer Agents; D010936:Plant Extracts; D002927:Cimetidine; D007213:Indomethacin