title: Alveolar ridge augmentation with Bio-Oss: a histologic study in humans.
abstract: The aim of the present study was to investigate the healing of alveolar ridge defects augmented with cancellous bovine bone mineral. In six partially edentulous patients, bone augmentation was necessary prior to implant placement because of severe alveolar ridge resorption. The defect sites, all located in the maxilla, were filled with Bio-Oss and covered with the resorbable collagen membrane Bio-Gide. Biopsies were obtained from the defect sites 6 to 7 months following grafting and were processed for ground sectioning. The histologic analysis revealed that the Bio-Oss particles occupied 31% of the total biopsy area. An intimate contact between woven bone and Bio-Oss was detected along 37% of the particle surfaces. A mixed type of bone was found; it contained woven bone and parallel-fibered bone, which demonstrates features of remodeling activity. Signs of resorption of the grafting material were observed in the histologic sections, which indicates that the material takes part in the remodeling process. It is suggested that Bio-Oss may be a very suitable material for staged localized ridge augmentation in humans.
authors.affiliation: Clinic of Fixed and Removable Prosthodontics and TMJ Disorders, University of Basel, Switzerland.
authors.forename: N U
authors.initials: NU
authors.lastname: Zitzmann
authors.forename: P
authors.initials: P
authors.lastname: Schärer
authors.forename: C P
authors.initials: CP
authors.lastname: Marinello
authors.forename: P
authors.initials: P
authors.lastname: Schüpbach
authors.forename: T
authors.initials: T
authors.lastname: Berglundh
mesh_terms: D000328:Adult; D000368:Aged; D000540:Alveolar Ridge Augmentation / Q000379:methods*; D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use; D001706:Biopsy; D001857:Bone Matrix / Q000637:transplantation*; D016723:Bone Remodeling / Q000502:physiology; D001862:Bone Resorption / Q000601:surgery; D018786:Bone Substitutes / Q000627:therapeutic use*; D002417:Cattle; D003094:Collagen / Q000627:therapeutic use; D015921:Dental Implants; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007576:Jaw, Edentulous, Partially / Q000473:pathology / Q000601:surgery*; D008297:Male; D008437:Maxilla / Q000473:pathology / Q000601:surgery*; D008439:Maxillary Diseases / Q000601:surgery; D008567:Membranes, Artificial; D008875:Middle Aged; D008903:Minerals / Q000627:therapeutic use*; D013223:Statistics as Topic; D013499:Surface Properties
chemical_list: C106416:Bio-Gide; C077540:Bio-Oss; D001672:Biocompatible Materials; D018786:Bone Substitutes; D015921:Dental Implants; D008567:Membranes, Artificial; D008903:Minerals; D003094:Collagen