title: Use of 99mTc (V) DMSA scintigraphy in the detection and localization of intestinal inflammation: comparison of findings and colonoscopy and biopsy.
abstract: OBJECTIVE
  To evaluate the potential use of technetium 99m (99mTc) (V) dimercaptosuccinic acid (DMSA) scintigraphy in the detection and localization of intestinal inflammation.
  
  
  METHODS
  In a prospective study, 62 patients who were suspected of having intestinal inflammation and 30 control subjects were enrolled. All patients underwent 99mTc (V) DMSA scintigraphy and colonoscopy with biopsy within 1 week. 99mTc (V) DMSA scintigrams were interpreted blindly with respect to clinical information, and radiotracer uptake in the bowel segments was graded. The findings were then compared with the results of the colonoscopy and colonoscopic biopsy.
  
  
  RESULTS
  In the detection of intestinal inflammation, findings at 99mTc (V) DMSA scintigraphy were as follows: true-positive in 55, false-positive in two, true-negative in 32, and false-negative in three. Overall sensitivity was 95%; overall specificity, 94%; and overall accuracy, 95%.
  
  
  CONCLUSIONS
  Our results show that 99mTc (V) DMSA scintigraphy is a useful noninvasive diagnostic test for the detection and localization of intestinal inflammation.
authors.affiliation: Department of Nuclear Medicine, National Cheng Kung University Hospital, 138 Sheng-Li Rd, Tainan 704, Taiwan.
authors.forename: B F
authors.initials: BF
authors.lastname: Lee
authors.forename: N T
authors.initials: NT
authors.lastname: Chiu
authors.forename: D C
authors.initials: DC
authors.lastname: Wu
authors.forename: K B
authors.initials: KB
authors.lastname: Tsai
authors.forename: G C
authors.initials: GC
authors.lastname: Liu
authors.forename: H S
authors.initials: HS
authors.lastname: Yu
authors.forename: S T
authors.initials: ST
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D003092:Colitis / Q000175:diagnosis / Q000000981:diagnostic imaging*; D003106:Colon / Q000473:pathology; D003113:Colonoscopy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D012680:Sensitivity and Specificity; D019783:Technetium Tc 99m Dimercaptosuccinic Acid
chemical_list: D019275:Radiopharmaceuticals; D019783:Technetium Tc 99m Dimercaptosuccinic Acid