title: Tie-1 tyrosine kinase is an independent prognostic indicator for invasive breast cancer.
abstract: Receptor tyrosine kinases are known to be involved in the growth, progression and metastasis of solid tumors. We investigated the relationship between tie-1 expression and progression of invasive ductal breast carcinoma with immunohistochemical analysis. Tie-1 protein was detected in the microvessel endothelial cells and cytoplasm of tumor cells. The tumor size and stage were significantly associated with the expression of tie-1, which portends a worse 5-year disease-free status (39.3% v 59.2%, p = 0.07) and overall survival rate (67.3% v 93%, p = 0.02) than those without tie-1 expression. Multivariate analysis demonstrated that larger tumor size, presence of lymph node metastasis and tie-1 expression were independent prognostic parameters, both in 5-year disease-free survival and overall survival. Patients with lymph node metastases and tie-1 expression had the worst 5-year disease-free survival (0%) and overall survival (42.4%) compared to those without tie-1 expression (50.2%, 85%). In lymph node negative patients, those without tie-1 expression had better 5-year disease-free survival and overall survival (72.9%, 100%) compared to those with tie-1 expression (65.5%, 87.7%). We conclude that tie-1 expression is an independent prognostic factor for invasive ductal breast carcinoma, adversely affecting survival of breast cancer patients with positive nodes to a significant extent.
authors.affiliation: Department of Surgery, Taipei-Veterans General Hospital, and School of Medicine, National Yang-Ming University, Taiwan.
authors.forename: L M
authors.initials: LM
authors.lastname: Tseng
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsu
authors.forename: H C
authors.initials: HC
authors.lastname: Wang
authors.forename: J M
authors.initials: JM
authors.lastname: Liu
authors.forename: H M
authors.initials: HM
authors.lastname: Chang
authors.forename: S S
authors.initials: SS
authors.lastname: Lo
authors.forename: C W
authors.initials: CW
authors.lastname: Wu
authors.forename: W Y
authors.initials: WY
authors.lastname: Lui
authors.forename: C W
authors.initials: CW
authors.lastname: Chi
mesh_terms: D014408:Biomarkers, Tumor / Q000096:biosynthesis; D001943:Breast Neoplasms / Q000201:enzymology* / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000201:enzymology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D011379:Prognosis; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis*; D042810:Receptor, TIE-1; D011956:Receptors, Cell Surface / Q000096:biosynthesis*; D042764:Receptors, TIE; D012189:Retrospective Studies
chemical_list: D014408:Biomarkers, Tumor; D011956:Receptors, Cell Surface; D020794:Receptor Protein-Tyrosine Kinases; D042810:Receptor, TIE-1; D042764:Receptors, TIE