[The changes in respiratory cycle, ventilation volume and blood analysis after bronchoalveolar lavage in dogs with steam inhalation injury].
OBJECTIVE
The changes in respiration cycle, ventilation volume and blood analysis after bronchoalveolar lavage(BAL) in dogs with steam induced inhalation injury were investigated to explore ways of treating inhalation injury.


METHODS
A bronchoscope was introduced down to the openings of the tertiary-quarternary bronchioles, and controlled volume BAL with drugs was done.


RESULTS
The inspiration time (Ti) and respiration cycle (Te) at 30, 60, 90 minutes after BAL were significantly lower than those of pre-BAL(P < 0.05), and respiration rate (RR) post-BAL at the same time points was markedly higher than that of pre-BAL(P < 0.05 or P < 0.01). The inspiratory minute ventilation volume (Vi) and expiratory minute ventilation volume (Ve) at 30 to 60 minutes after BAL were obviously increased as compared to pre-BAL(P < 0.01-P < 0.05); Vi and Ve at 90 minutes after BAL were also higher than those of pre-BAL, but there was no significant difference between them. The PaO2 at 30 minutes after BAL declined obviously as compared to pre-BAL(P < 0.05), and then rose gradually to approach pre-BAL level compared with pre-BAL. No significant changes were found in the expiration time (Te), ration of Ti to Te (Ti/Te), inspiratory tidal volume (Vti), expiratory tidal volume (Vte), PaCO2 and pH between values before and after BAL at all time points.


CONCLUSIONS
Controlled volume BAL with mixed drugs could improve lung alveolar ventilation, and it might have an excitory effect on respiration with potential clinical value.
Guo
G
G
Burn Center, First Affiliated Hospital of Jiangxi Medical College, Nanchang, 330006.
Xiong
L
L
Li
G
G
D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous; D018893:Bronchoalveolar Lavage; D002059:Burns, Inhalation / Q000097:blood / Q000503:physiopathology* / Q000628:therapy*; D003907:Dexamethasone / Q000008:administration & dosage; D004285:Dogs; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D012123:Pulmonary Ventilation; D011897:Random Allocation; D012119:Respiration; D012601:Scopolamine / Q000008:administration & dosage
D003907:Dexamethasone; D012601:Scopolamine