[Clinical significance of sialyl SSEA-1 (SLX) in patients with idiopathic interstitial pneumonia].
Serum SLX levels were measured in 29 patients with idiopathic interstitial pneumonia (IIP) to evaluate its clinical significance. Serum SLX had positive correlations with the BALF neutrophil ratio but not with the severity or the disease activity in patients with IIP, and bronchoalveolar lavage fluid (BALF) SLX had positive correlations with the BALF neutrophil count. Epithelial lining fluid (ELF) SLX levels showed positive correlations with serum SLX, but were much higher. These results suggest that increases of serum SLX may reflect increases of SLX in the lung tissues. Thus, we speculate that increases of the serum SLX level may represent increases of the BALF neutrophil count. Patients with higher SLX showed poor therapeutic responses and poor prognoses in comparison with those with normal SLX for the reason that serum SLX level represents BALF neutrophil level.
Totani
Y
Y
Third Department of Internal Medicine, Fukui Medical University, Matsuoka-town, Fukui 910-1193, Japan.
Demura
Y
Y
Ameshima
S
S
Miyamori
I
I
Ishizaki
T
T
D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D005260:Female; D006801:Humans; D016256:Lewis X Antigen / Q000097:blood*; D017563:Lung Diseases, Interstitial / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009504:Neutrophils
D016256:Lewis X Antigen