Is tubal embryo transfer of any value? A meta-analysis and comparison with the Society for Assisted Reproductive Technology database.
OBJECTIVE
To analyze published randomized trials of ZIFT and ET via meta-analysis and compare the results with those of the Society for Assisted Reproductive Technology database.


METHODS
Meta-analysis and comparison to SART data sets for 1991-1996.


METHODS
University medical center.


METHODS
Patients from the literature with infertility, randomized to either tubal or uterine embryo transfer.


METHODS
All published articles in English were identified using an electronic database spanning January 1966 to December 1998 by keyword and text word searches, supplemented with a hand search through the references of original studies, review articles, and conference abstracts to identify randomized trials comparing ZIFT and IVF-ET. Additional data was obtained through correspondence with authors.


METHODS
Implantation and clinical pregnancy rates were compared. Ectopic pregnancy rate was a secondary outcome measure.


RESULTS
Six randomized controlled trials including 548 cycles, 514 retrievals, and 388 transfers were reviewed. Demographic and stimulation and transfer details were comparable between the groups. Implantation and pregnancy rates did not differ significantly, and there was a trend toward increased risk of ectopic pregnancy with ZIFT.


CONCLUSIONS
Published randomized trials suggest that there is no difference in implantation and pregnancy rates between women undergoing ZIFT and IVF-ET.
Habana
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AE
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven,CT 06510, USA.
Palter
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SF
D016208:Databases, Factual; D004624:Embryo Transfer / Q000379:methods*; D005187:Fallopian Tubes; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D016239:MEDLINE; D008297:Male; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012042:Registries; D012099:Reproductive Techniques; D014599:Uterus