Influence of maternal and fetal glucokinase mutations in gestational diabetes.
We report 2 insulin-treated pregnancies in a mother with hyperglycemia resulting from a glucokinase gene mutation. The inheritance of a glucokinase mutation in 1 child reduced his intrauterine growth (birth weight less than first percentile) by reducing fetal insulin secretion. We discuss the implications for obstetric management of patients with glucokinase mutations.
Spyer
G
G
Department of Diabetes and Vascular Medicine, School of Postgraduate Medicine, Royal Devon and Exeter Hospital, Barrack Road, Exeter, UK.
Hattersley
A T
AT
Sykes
J E
JE
Sturley
R H
RH
MacLeod
K M
KM
D000328:Adult; D003920:Diabetes Mellitus / Q000201:enzymology; D016640:Diabetes, Gestational / Q000201:enzymology*; D005260:Female; D005315:Fetal Diseases / Q000201:enzymology / Q000235:genetics; D005317:Fetal Growth Retardation / Q000201:enzymology / Q000235:genetics; D005333:Fetus / Q000201:enzymology*; D005941:Glucokinase / Q000235:genetics*; D006801:Humans; D006943:Hyperglycemia / Q000201:enzymology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D009154:Mutation; D009765:Obesity; D010375:Pedigree; D011247:Pregnancy
D007328:Insulin; D005941:Glucokinase