Immune reactivity during the growth of a murine lung adenocarcinoma: evaluation of paraneoplastic syndrome development.
The purpose of this study was to investigate if specific immune responses were present in mice bearing a lung adenocarcinoma that presents paraneoplastic syndromes during tumor evolution. Leukocytosis, mainly due to polymorphonuclear leukocytes, was found from day 15 of tumor growth. Delayed type hypersensitivity response and increased interleukin-6 (IL-6) serum levels were observed along tumor growth. Concomitant immunity, specific rejection of a second inoculum and in vitro specific cytotoxicity occurred at 20 days of implant. In advanced stages of tumor evolution impaired cytotoxicity, accompanied by a great increase of IL-6 in serum, were observed. Role of polymorphonuclear leukocytes and IL-6 overproduction as responsible for immune dysregulation and paraneoplastic syndromes are discussed.
Diament
M J
MJ
Animal Care and Experimental Cancer Department, Institute of Oncology A.H. Roffo, Buenos Aires, Argentina. bioterioroffo@yahoo.com
García
C
C
Parma
M
M
Mondelo
N
N
Stillitani
I
I
Klein
S
S
D000230:Adenocarcinoma / Q000097:blood / Q000276:immunology*; D000818:Animals; D002455:Cell Division; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007114:Immunization; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008175:Lung Neoplasms / Q000097:blood / Q000276:immunology*; D008214:Lymphocytes / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D010257:Paraneoplastic Syndromes / Q000097:blood / Q000276:immunology*; D013154:Spleen / Q000473:pathology; D014407:Tumor Cells, Cultured
D015850:Interleukin-6