[Effect of Fucong tablets and its ingredients on ototoxicity of gentamycin in guinea pigs].
OBJECTIVE
To assess the antagonistic effect of Fucong Tablet (FCT) and its ingredients on ototoxicity of gentamycin in guinea pigs.


METHODS
The guinea pigs were given gentamycin 80 mg/kg intramuscularly once daily for 20 days and FCT or its ingredients separately oral taken for 20 days. The auditory brain stem evoked response (ABR) threshold, vascular stria blood circulation condition, outer hair-cell count and cochlear ultrastructure of guinea pigs were observed before and after treatment to assess the antagonistic effect and protective effect of FCT on cochlear structure.


RESULTS
FCT and its ingredients of tonifying Kidney, replenishing Qi and blood, promoting blood circulation could lower the impairment ratio of outer hair-cell induced by gentamycin (P < 0.05), protect morphosis and function of cochlea and lower the elevated ABR threshold (P < 0.05).


CONCLUSIONS
FCT and its ingredients could reduce the toxic damage on ear induced by gentamycin effectively.
Xu
S
S
Second Affiliated Hospital, Hunan TCM College, Changsha 410005.
Peng
B
B
Liu
J
J
D000818:Animals; D003051:Cochlea / Q000503:physiopathology / Q000648:ultrastructure*; D015834:Cochlear Diseases / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000648:ultrastructure; D006312:Hearing Loss, Bilateral / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology*; D008297:Male; D011897:Random Allocation
D004365:Drugs, Chinese Herbal; D005839:Gentamicins