title: Solid-phase analysis method for (S)-[18F]fluorocarazolol and its metabolites.
abstract: (S)-[18F]Fluorocarazolol is a radiopharmaceutical developed to quantitatively assess beta-adrenergic receptors in vivo via positron emission tomography imaging. Since radioactive metabolites of (S)-[18F]fluorocarazolol rapidly appear in the plasma, methods for conveniently and reliably evaluating plasma for (S)-[18F]fluorocarazolol content are required. Here we present methods and validation of an approach using commercial extraction cartridges that is faster and more convenient than an approach using internal-surface reverse-phase chromatography but yields comparable results.
authors.affiliation: Case Western Reserve University, Cleveland, OH 44106, USA. rfm2@po.cwru.edu
authors.forename: R F
authors.initials: RF
authors.lastname: Muzic
authors.forename: B
authors.initials: B
authors.lastname: Landmeier
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Zheng
authors.forename: M S
authors.initials: MS
authors.lastname: Berridge
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000097:blood*; D002227:Carbazoles / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D011412:Propanolamines / Q000097:blood*; D019275:Radiopharmaceuticals / Q000097:blood*; D012680:Sensitivity and Specificity
chemical_list: D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D019275:Radiopharmaceuticals; C089702:fluorocarazolol