An expeditious approach toward the total synthesis of CP-263,114.
[reaction: see text] Assembly of the carbocyclic core of CP-263,114 has been accomplished efficiently and in high yield. Key steps include a phenolic oxidation/intramolecular Diels-Alder sequence, tandem radical cyclization, and the late-stage fragmentation of a densely functionalized isotwistane skeleton.
Njardarson
J T
JT
Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
McDonald
I M
IM
Spiegel
D A
DA
Inoue
M
M
Wood
J L
JL
D003500:Cyclization; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008299:Maleic Anhydrides / Q000138:chemical synthesis*; D008958:Models, Molecular; D010084:Oxidation-Reduction
C104957:CP 263114; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D008299:Maleic Anhydrides