Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice.
In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.
Lauw
F N
FN
Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands.
Florquin
S
S
Speelman
P
P
van Deventer
S J
SJ
van der Poll
T
T
D000818:Animals; D004768:Enterotoxins / Q000008:administration & dosage* / Q000276:immunology*; D018664:Interleukin-12 / Q000378:metabolism*; D020382:Interleukin-18 / Q000378:metabolism; D051379:Mice; D013154:Spleen / Q000276:immunology; D013211:Staphylococcus aureus / Q000378:metabolism*; D018089:Superantigens / Q000008:administration & dosage / Q000276:immunology
D004768:Enterotoxins; D020382:Interleukin-18; D018089:Superantigens; D018664:Interleukin-12; C031818:enterotoxin B, staphylococcal