[Activity of imipenem and meropenem against strains of Acinetobacter baumannii isolated from various Chilean hospitals].
The activity of two carbapenem compounds, imipenem and meropenem, against 447 strains of Acinetobacter baumannii isolated between 1990 and 1998 in different Chilean hospitals was determined. MIC ranges, MIC(50) and MIC(90), were determined by an agar dilution method. Similar antibacterial activities were observed for both antibacterials; however, a slight increase in the MIC(50) of imipenem and meropenem, and in the MIC(90) of meropenem was found among strains isolated from 1997-1998. Although A. baumannii remains susceptible to these antibiotics, the MIC(50) and MIC(90) have increased in recent years.
Bello
H
H
Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile.
Domínguez
M
M
Sepúlveda
M
M
Cerda
F
F
González
G
G
Mella
S
S
Zemelman
R
R
D000150:Acinetobacter / Q000187:drug effects*; D000151:Acinetobacter Infections / Q000188:drug therapy* / Q000382:microbiology; D002677:Chile; D003428:Cross Infection / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D015378:Imipenem / Q000627:therapeutic use*; D000077731:Meropenem; D013845:Thienamycins / Q000627:therapeutic use*
D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem