Platelet glycoproteins and their role in diseases.
The role of platelet glycoprotein receptors in disorders caused by their absence or defects such as in Bernard-Soulier syndrome or Glanzmann's thrombasthenia has been known for many decades now. Their function as targets for pathological antibodies is also well established. The possible roles of platelet receptors or their polymorphism variants in the origins of diseases such as cardiovascular disorders are less well studied. Investigation of this area began about five years ago and many findings still remain controversial. The involvement of platelet receptors in other diseases like asthma, diabetes and HIV are only starting to be studied.
Clemetson
K J
KJ
Theodor Kocher Institute, University of Berne, Switzerland. clemetson@tki.unibe.ch
D016824:Antigens, Human Platelet / Q000235:genetics / Q000276:immunology / Q000502:physiology; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology; D001791:Blood Platelet Disorders / Q000097:blood* / Q000235:genetics; D002318:Cardiovascular Diseases / Q000097:blood / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D010980:Platelet Membrane Glycoproteins / Q000172:deficiency / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D011110:Polymorphism, Genetic; D011991:Receptors, Virus / Q000502:physiology
D016824:Antigens, Human Platelet; D001323:Autoantibodies; D010980:Platelet Membrane Glycoproteins; D011991:Receptors, Virus