Association of the T102C polymorphism of 5-HT2A receptor gene with aura in migraine.
OBJECTIVE
To find out the significance of the 5-HT2A receptor gene polymorphism in migraine.


METHODS
A PCR study in which 61 migraineurs and 44 healthy controls were included.


METHODS
The T102C polymorphism of the 5-HT2A receptor gene was studied. The results of the migraineurs and controls were compared. The relationship between the gene polymorphism and aura was also assessed.


RESULTS
The representations of the 5-HT2A genotypes were similar in migraineurs and controls (p>0.05) as well as in the male and female migraineurs (p>0.05). The family history of migraine did not associate with 5-HT2A receptor gene polymorphism (p>0.05). There was a significant relationship between the presence of C/C genotype and migraine with aura (p=0.02) while C/T and T/T genotypes were over represented in the patients with migraine without aura (p<0.01).


CONCLUSIONS
The T102C polymorphism of the 5-HT2A receptor gene is not directly related to the increased risk of migraine. The associations between the genotypes of this gene and aura may suggest that 5-HT2A receptor gene polymorphism may be involved in determining the subtypes of or accompanying symptoms in the migraine disease.
Erdal
M E
ME
Department of Medical Biology and Genetics, Faculty of Medicine, Mersin University, Mersin, Turkey.
Herken
H
H
Yilmaz
M
M
Bayazit
Y A
YA
D000328:Adult; D005260:Female; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D020325:Migraine with Aura / Q000235:genetics*; D011110:Polymorphism, Genetic; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000235:genetics*; D012016:Reference Values
D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin