Testing a degradable topical varnish of cetylpyridinium chloride in an experimental dental biofilm model.
Dental biofilms are highly associated with the development of dental caries. Novel drug delivery systems are being developed in order to eliminate cariogenic bacteria from the dental biofilms. We formulated two degradable sustained release varnishes, based on acrylic resin, with cetylpyridinium chloride (CPC) as the active agent. These formulations were tested in a dental biofilm model. The retention of CPC in the biofilm was dependent upon the pharmaceutical additives of the varnish. Both varnishes decreased bacterial adhesion, while also demonstrating marked antibacterial properties against the bacteria in the biofilm.
Steinberg
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D
Department of Oral Biology, Faculty of Dentistry, the Hebrew University - Hadassah, PO Box 12272, Jerusalem 91120, Israel. dorons@cc.huji.ac.il
Moldovan
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M
Molukandov
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D
D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001422:Bacterial Adhesion / Q000187:drug effects; D018441:Biofilms / Q000187:drug effects*; D002594:Cetylpyridinium / Q000494:pharmacology*; D003270:Contraceptive Agents / Q000494:pharmacology*; D003736:Dental Cavity Lining / Q000379:methods; D006801:Humans; D008954:Models, Biological; D013291:Streptococcus / Q000187:drug effects
D000891:Anti-Infective Agents, Local; D003270:Contraceptive Agents; D002594:Cetylpyridinium