Smooth muscle cell depletion and collagen types in progeric arteries.
Review of two autopsy cases of progeria confirms severe smooth muscle cell (SMC) depletion in the atherosclerotic aortic media and the presence of collagen types I, III, IV, V, and VI in the aorta and renal vessels as is consistent with atherosclerotic disease.
Stehbens
W E
WE
Department of Pathology and Molecular Medicine, Wellington School of Medicine, PO Box 7343, South, Wellington, New Zealand. w.e.stehbens@xtra.co.nz
Delahunt
B
B
Shozawa
T
T
Gilbert-Barness
E
E
D000328:Adult; D000368:Aged; D001011:Aorta / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000209:etiology / Q000378:metabolism / Q000473:pathology; D001808:Blood Vessels / Q000378:metabolism / Q000473:pathology; D002648:Child; D003094:Collagen / Q000145:classification / Q000378:metabolism*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism* / Q000473:pathology*; D011371:Progeria / Q000150:complications / Q000378:metabolism* / Q000473:pathology*; D012016:Reference Values; D012079:Renal Circulation
D003094:Collagen