title: T1-weighted MR imaging for distinguishing large osteolysis of Paget's disease from sarcomatous degeneration.
abstract: OBJECTIVE
  To report five symptomatic patients, four with unequivocal Paget's disease and large areas of osteolysis and one patient with presumed osteolytic Paget's disease, evaluated by MR imaging to confirm or exclude a sarcoma.
  
  
  METHODS
  Four men and one woman (median age 74 years) presented with new symptoms of pain. Four of these patients had unequivocal Paget's disease with large areas of osteolysis; one patient presented with large focal osteolysis and no other finding. MR imaging was performed in each case to exclude malignancy in the area of osteolysis.
  
  
  RESULTS
  Two patients whose MR images showed a low signal abnormality on the T1-weighted sequence corresponding to osteolysis on the radiograph were found to have malignant degeneration. Three patients with osteolytic lesions on T1-weighted MR imaging showed preservation of fat signal in the areas of osteolysis, were not biopsied and have been free of malignant disease for from 12 months to 2 1/2 years. One patient had one area of osteolysis in the iliac bone which showed malignancy and another area of osteolysis which showed preservation of fat signal on the T1-weighted sequence.
  
  
  CONCLUSIONS
  The information obtained from T1-weighted MR imaging sequences performed on patients with Paget's disease who have new symptoms and large areas of osteolysis could reliably be used in the clinical decision-making process between conservative follow-up and biopsy.
authors.affiliation: Department of Radiology, St. Louis University Health Sciences Center, MO 63110-0250, USA.
authors.forename: M
authors.initials: M
authors.lastname: Sundaram
authors.forename: G
authors.initials: G
authors.lastname: Khanna
authors.forename: G Y
authors.initials: GY
authors.lastname: El-Khoury
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007085:Ilium; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010014:Osteolysis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012516:Osteosarcoma / Q000175:diagnosis*; D011859:Radiography