title: [The expression of IL-1 alpha gene in gingival tissue].
abstract: IL-1 is secreted by a variety of cells and plays an important role in the network of cytokines. In this study, the expression of IL-1 alpha in gingival tissue was determined with reverse transcription-polymerase chain reaction (RT-PCR). The PCR-product was confirmed by DNA sequencing. The results showed that IL-1 alpha transcription was detected in all 5 inflammatory gingival tissue samples, but it was not delected in the normal gingival tissue samples and in the samples after treatment. These findings suggested that IL-1 alpha may be a specific indicator of periodontal disease, and a potential mediator in pathogenesis of periodontitis.
authors.affiliation: College of Stomatology, Fourth Military Medical University.
authors.forename: H
authors.initials: H
authors.lastname: Song
authors.forename: Z
authors.initials: Z
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Zhao
mesh_terms: D015870:Gene Expression; D005881:Gingiva / Q000378:metabolism*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000235:genetics*; D010518:Periodontitis / Q000235:genetics*; D020133:Reverse Transcriptase Polymerase Chain Reaction
chemical_list: D007375:Interleukin-1