title: New insights into insulin resistance pathophysiology: how it affects glucose and lipid metabolism.
abstract: Insulin resistance is a metabolic state encountered in many physiological and physiopathological conditions. Its pivotal effect on glucose and lipid metabolism is increasingly recognised. Over the last few years, numerous molecular/intracellular pathways affected by this condition have been elucidated. The author reviews some recent findings underlying several major metabolic abnormalities. An overview of current and future therapeutics is also provided.
authors.affiliation: Centre Hospitalier Jolimont-Lobbes, Rue Ferrer, 159, B-7100 Haine-St-Paul, Belgium. vcol@wanadoo.be
authors.forename: V
authors.initials: V
authors.lastname: Col
mesh_terms: D000818:Animals; D005544:Forecasting; D015870:Gene Expression / Q000502:physiology; D005947:Glucose / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism; D008055:Lipids / Q000235:genetics
chemical_list: D008055:Lipids; D005947:Glucose