title: Endothelial dysfunction and progressive coronary atherosclerosis: sequential invasive studies in a patient with multiple cardiac risk factors.
abstract: This manuscript describes sequential angiographic, endothelial and vasoreactivity characteristics of the coronary arterial circulation in a middle-aged patient with multiple cardiac risk factors who developed hemodynamically significant coronary atherosclerosis over a 6-year period. A 56-year-old woman demonstrated marked angiographic progression of coronary atherosclerosis over time beginning with minor luminal irregularities in the setting of severe endothelial dysfunction. The association of endothelial dysfunction, ineffective cardiac risk factor management and progressive atherosclerosis is discussed.
authors.affiliation: Division of Cardiology, Albany Medical College, Albany, NY 12208, USA.
authors.forename: R
authors.initials: R
authors.lastname: Chander
authors.forename: P A
authors.initials: PA
authors.lastname: Kuhner
authors.forename: J
authors.initials: J
authors.lastname: Laws Houghton
mesh_terms: D006328:Cardiac Catheterization; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D003324:Coronary Artery Disease / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D004730:Endothelium, Vascular / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D012307:Risk Factors; D015607:Stents; D013997:Time Factors