title: Primary angiocentric T-cell intestinal lymphoma with Epstein-Barr virus in a 5-year-old boy.
abstract: A case of peripheral T-cell lymphoma affecting the small bowel of a 5-year-old boy is reported. The cells did not form a tumoral mass but infiltrated diffusely, arranged in an angiocentric pattern and associated with numerous ulcers, one of which perforated. Immunohistochemistry proved them to be CD45RO-, CD3-, and CD8-positive. CD20, CD4, and CD56 markers were negative. The presence of EBV in the lymphomatous cells was demonstrated by in-situ hybridization. Polymerase chain reaction study revealed T-cell receptor (TCR) gene rearrangement. Notably the hemophagocytic syndrome present on admission reverted after surgery. The authors are not aware of a previous report of intestinal T-cell lymphoma in a child.
authors.affiliation: Servicio de Patología, Hospital de Niños Superiora Sor María Ludovica, 1900, La Plata, Argentina.
authors.forename: R
authors.initials: R
authors.lastname: Drut
authors.forename: R M
authors.initials: RM
authors.lastname: Drut
mesh_terms: D002675:Child, Preschool; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D017404:In Situ Hybridization, Fluorescence; D007414:Intestinal Neoplasms / Q000473:pathology* / Q000821:virology*; D016399:Lymphoma, T-Cell / Q000473:pathology* / Q000821:virology*; D008297:Male; D016133:Polymerase Chain Reaction