Higher carbohydrate intake is associated with decreased incidence of newborn macrosomia in women with gestational diabetes.
OBJECTIVE
To study the influence of energy and macronutrient intake on infant birthweight in women with gestational diabetes mellitus undergoing intensive management.


METHODS
This prospective study evaluated the impact of intensive management of gestational diabetes on maternal and fetal morbidity, and addressed the relationship between food intake and infant birthweight.


METHODS
Fifteen maternity hospitals in northern France.


METHODS
Ninety-nine women with gestational diabetes or gestational mild hyperglycemia diagnosed between 24 and 34 weeks of gestation were surveyed. After 1 was excluded because of a premature birth and 18 were excluded as underreporters, 80 women were included in the final analysis. Diet intake was assessed by a dietary history at the first interview, and by two 3-day diet records at the 3rd and 7th week after diagnosis.


RESULTS
In a forward-stepwise regression analysis (controlling for maternal age; smoking; parity; prepregnancy BMI; pregnancy weight gain; gestational duration; infant sex; fasting and 2-hour postprandial serum glucose; insulin therapy; and energy, fat, protein and carbohydrate intake during treatment) infant birthweight was positively associated with gestational duration (beta = +0.34, P<.002), and negatively with smoking (beta = -0.27, P<.02) and carbohydrate intake (beta = -0.24, P<.03). There were no large-for-gestational-age infants among women whose carbohydrate intake exceeded 210 g/day.


CONCLUSIONS
For women with gestational diabetes undergoing intensive management, higher carbohydrate intake is associated with decreased incidence of macrosomia.


CONCLUSIONS
These findings suggest that nutrition counseling in gestational diabetes must be directed to maintain a sufficient carbohydrate intake (at least 250 g per day), which implies a low-fat diet to limit energy intake. A careful distribution of carbohydrate throughout the day and the use of low-glycemic index foods may help limit postprandial hyperglycemia.
Romon
M
M
Service de Nutrition, Faculté de Médecine, Lille, France. mromon@univ-lille2.fr
Nuttens
M C
MC
Vambergue
A
A
Vérier-Mine
O
O
Biausque
S
S
Lemaire
C
C
Fontaine
P
P
Salomez
J L
JL
Beuscart
R
R
D000328:Adult; D001724:Birth Weight; D001786:Blood Glucose / Q000032:analysis; D016640:Diabetes, Gestational / Q000097:blood / Q000150:complications* / Q000178:diet therapy* / Q000401:mortality; D015930:Diet Records; D004034:Diet Surveys; D003927:Diet, Diabetic; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D002149:Energy Intake; D005260:Female; D005320:Fetal Macrosomia / Q000209:etiology* / Q000401:mortality / Q000517:prevention & control; D005865:Gestational Age; D006801:Humans; D006943:Hyperglycemia / Q000178:diet therapy / Q000517:prevention & control; D015994:Incidence; D007231:Infant, Newborn; D009747:Nutritional Physiological Phenomena; D009751:Nutritional Requirements; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood / Q000178:diet therapy / Q000401:mortality; D011256:Pregnancy Outcome; D011262:Pregnancy Trimester, Second; D011446:Prospective Studies; D012044:Regression Analysis
D001786:Blood Glucose; D004040:Dietary Carbohydrates