Platelet-endothelial interactions in atherosclerosis.
The pathogenesis of atherosclerosis, the leading cause of morbidity and mortality in the United States, is multifactorial. Many factors that have been shown to influence the development of atherosclerosis also affect the function of the endothelium through soluble or cell-cell interactions. Among these, interactions between platelets and endothelial cells have only recently begun to receive systematic study. This article reviews recent evidence showing how the interaction between platelets and endothelial cells may play a important role in the pathogenesis of atherosclerosis, suggesting an underappreciated potential locus for pharmacologic intervention.
Sachais
B S
BS
Department of Pathology and Laboratory Medicine, University of Pennsylvania, 3620 Hamilton Walk, 207A John Morgan Building, Philadelphia, PA 19104, USA. sachais@mail.med.upenn.edu
D015703:Antigens, CD; D001081:Apyrase / Q000378:metabolism; D001161:Arteriosclerosis / Q000188:drug therapy / Q000503:physiopathology*; D001792:Blood Platelets / Q000166:cytology; D002352:Carrier Proteins / Q000378:metabolism; D002448:Cell Adhesion / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism / Q000503:physiopathology*; D011464:Epoprostenol / Q000378:metabolism; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism; D019007:P-Selectin / Q000378:metabolism; D010972:Platelet Activating Factor / Q000378:metabolism; D011973:Receptors, LDL / Q000378:metabolism; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E; D044767:Ubiquitin-Protein Ligases
D015703:Antigens, CD; D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D000960:Hypolipidemic Agents; C495137:OLR1 protein, human; D019007:P-Selectin; D010972:Platelet Activating Factor; D011973:Receptors, LDL; D051131:Receptors, Oxidized LDL; D051127:Scavenger Receptors, Class E; D009569:Nitric Oxide; D011464:Epoprostenol; D019001:Nitric Oxide Synthase; C419706:NOSIP protein, human; D044767:Ubiquitin-Protein Ligases; D001081:Apyrase; C067869:CD39 antigen