[Changes of osteopontin and matrix Gla protein mRNA expressions in the healing process of rat thoracic aorta damaged by balloon angioplasty].
Using Northern blot and reverse transcriptase-polymerase chain reaction (RT-PCR) the dynamic changes of osteopontin (OPN) and matrix Gla protein (MGP) mRNA expression in the healing process of rat thoracic aorta damaged by balloon angioplasty were investigated. The results showed that expression of OPN and MGP in the thoracic aorta damaged group was higher compared with normal group. 1, 7, and 14 d after thoracic aorta was damaged, expression of OPN and MGP was increased gradually, and decreased after artery damaged 21 d.
Liu
P
P
Institute of Clinical Pharmacology, Tongji Medical University, Wuhan 430030.
Chen
H
H
Cheng
Y
Y
Zeng
F D
FD
Tang
C S
CS
D015055:1-Carboxyglutamic Acid / Q000096:biosynthesis / Q000235:genetics; D000800:Angioplasty, Balloon; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002135:Calcium-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D016326:Extracellular Matrix Proteins; D008297:Male; D053495:Osteopontin; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012795:Sialoglycoproteins / Q000096:biosynthesis* / Q000235:genetics; D000097568:Matrix Gla Protein
D015055:1-Carboxyglutamic Acid; D002135:Calcium-Binding Proteins; D016207:Cytokines; D016326:Extracellular Matrix Proteins; D053495:Osteopontin; D012333:RNA, Messenger; D012795:Sialoglycoproteins; D000097568:Matrix Gla Protein; C506897:Spp1 protein, rat