title: Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.
abstract: The present study determined the detailed pharmacological profile of heterologously expressed human (h) homomeric 5-HT3A receptors in direct comparison to heteromeric h5-HT3A/3B receptors. The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subunit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor.
authors.affiliation: Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Brady
authors.forename: I M
authors.initials: IM
authors.lastname: Stanford
authors.forename: I
authors.initials: I
authors.lastname: Ali
authors.forename: L
authors.initials: L
authors.lastname: Lin
authors.forename: J M
authors.initials: JM
authors.lastname: Williams
authors.forename: A E
authors.initials: AE
authors.lastname: Dubin
authors.forename: A G
authors.initials: AG
authors.lastname: Hope
authors.forename: N M
authors.initials: NM
authors.lastname: Barnes
mesh_terms: D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D015640:Ion Channel Gating; D007668:Kidney / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011985:Receptors, Serotonin / Q000096:biosynthesis* / Q000145:classification; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin / Q000494:pharmacology
chemical_list: D016166:Free Radical Scavengers; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin