[Effect of intracerebroventricular neurotensin injection on blood pressure in rat].
Injection of neurotensin (NT) (10 and 20 micrograms/rat) into the lateral cerebroventricle (icv) could induce a rise or a drop of blood pressure and a slowing down of heart rate in urethane anaesthetized male rats (1.2 g/kg). The central pressor and depressor response to NT could be respectively blocked by pretreatment with alpha 1-receptor blocker prazosin (1.5 micrograms/3 microliters, icv) and M receptor blocker atropine (2.5 micrograms/3 microliters, icv). No significant changes in central cardiovascular responses to NT were observed following pretreatment with either H1 receptor blocker chlorpheniramin (50 micrograms/3 microliters, icv) or H2 receptor blocker cimetidine (250 micrograms/3 microliters, icv). In view of the above results it appears that NT, catecholamine and acetylcholine are all involved in central regulation of blood pressure.
Zhang
X H
XH
Department of Physiology, Nanjing Medical University, Nanjing 210029.
Yin
G X
GX
Ni
H
H
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology; D009496:Neurotensin / Q000494:pharmacology*; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley
D000317:Adrenergic alpha-Antagonists; D018727:Muscarinic Antagonists; D009496:Neurotensin; D001285:Atropine; D011224:Prazosin