Origin of an animal mitochondrial DNA polymerase subunit via lineage-specific acquisition of a glycyl-tRNA synthetase from bacteria of the Thermus-Deinococcus group.
Phylogenetic tree analysis shows that the accessory subunit animal mitochondrial DNA polymerase emerges as a result of horizontal transfer of the gene encoding glycyl-tRNA synthetase from a bacterium of the Thermus-Deinococcus group into the animal nuclear genome. This acquisition by a distinct eukaryotic lineage of a gene encoding a mitochondrial protein from a nonmitochondrial bacterial source underscores the contribution of different types of horizontal transfer event to the evolution of eukaryotes.
Wolf
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National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Bethesda, MD 20894, USA.
Koonin
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EV
D000818:Animals; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry* / Q000235:genetics*; D004331:Drosophila melanogaster; D019143:Evolution, Molecular; D006032:Glycine-tRNA Ligase / Q000235:genetics*; D008928:Mitochondria / Q000201:enzymology*; D008957:Models, Genetic; D010802:Phylogeny; D017434:Protein Structure, Tertiary; D014982:Xenopus laevis
D004259:DNA-Directed DNA Polymerase; D006032:Glycine-tRNA Ligase