Use of win-stay and win-shift strategies in place and cue tasks by medial caudate putamen (MCPu) lesioned rats.
This study investigated the behavioral function of the medial caudate putamen (MCPu) in the solving of maze tasks. MCPu lesioned rats (n = 35) and control rats (n = 35) were trained for the place or cue task (the four baited arms and four unbaited arms task) in an eight-arm radial maze, which requires the win-stay or the win-shift strategy. In Experiment 1, in which the place task was used, MCPu lesioned rats could learn the task in the win-shift condition, but not in the win-stay condition. MCPu lesioned rats made a lot of unbaited errors in the win-stay condition, as they persistently chose adjacent arms. Control rats could learn the tasks in both conditions. In Experiment 2, in which the cue task was used, MCPu lesioned rats and control rats could learn the tasks in both the win-stay and the win-shift conditions. If anything, the performance of MCPu rats was a little better than that of control rats in the win-stay condition. The results of these two experiments revealed that the MCPu was involved in solving the win-stay place task, but not the win-shift place, win-stay cue, and win-shift cue tasks. These findings suggest that the MCPu plays an important role in utilizing both spatial information and switching foraging strategies flexibly and efficiently, that is, processing complicated visuospatial cognition.
Sakamoto
T
T
Laboratory for Neurobiology of Emotion, Brain Science Institute (BSI), RIKEN, Wako-City, Saitama, 351-0198, Japan. tsakamoto@brain.riken.go.jp
Okaichi
H
H
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002421:Caudate Nucleus / Q000473:pathology*; D003072:Cognition Disorders / Q000175:diagnosis; D003463:Cues; D004195:Disease Models, Animal; D006185:Habituation, Psychophysiologic; D008297:Male; D018782:Maze Learning / Q000502:physiology; D010468:Perceptual Disorders / Q000175:diagnosis; D051381:Rats; D017208:Rats, Wistar; D013028:Space Perception / Q000502:physiology; D014796:Visual Perception / Q000502:physiology