Determination of molecular sulphur in sodium thiosulphate injection solutions by high performance liquid chromatography.
A method was developed to quantify the sulphur formed in decomposed sodium thiosulphate injection solutions. Elemental sulphur was extracted with cyclohexane (LLE) and analysed by RP-HPLC. A linear calibration curve with a detection limit of 24 micrograms/ml was obtained. Different amounts of sulphur were detected in extemporaneous and commercial solutions.
Miethe
G
G
Institute of Pharmacy, Humboldt University Berlin, Germany. miethe@berlin.vci.de
Surmann
J P
JP
D002138:Calibration; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D019999:Pharmaceutical Solutions; D013056:Spectrophotometry, Ultraviolet; D013242:Sterilization; D013455:Sulfur / Q000032:analysis*; D013885:Thiosulfates / Q000032:analysis*
D019999:Pharmaceutical Solutions; D013885:Thiosulfates; D013455:Sulfur; C017717:sodium thiosulfate