Bone marrow colony-forming unit assay in cats with naturally occurring myelodysplastic syndromes.
Feline myelodysplastic syndromes (MDS) has been diagnosed in many cats infected with feline leukemia virus, although the pathogenesis of this hematopoietic deficiency has been unclear. In this study, we assayed the bone marrow erythroid colony-forming units (CFU-E) and granulocyte-machrophage CFUs (CFU-GM) to investigate the pathogenesis of feline MDS. The number of CFU-E colonies was decreased in 4 of 7 cats with MDS, and the number of CFU-GM colonies was also decreased in 4 cats. Furthermore, small colonies of CFU-GM were found in all 7 cases. These findings indicated that refractory cytopenia of feline MDS could be caused by abnormal maturation and differentiation of hematopoietic stem cells in bone marrow, as it is in human MDS. The pathogenesis of feline MDS might be similar to that of human MDS.
Nagashima
Naho
N
Department of Pathobiology, School of Veterinary Medicine, Nihon University, Kanagawa.
Hisasue
Masaharu
M
Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University, Kanagawa.
Higashi
Katsumi
K
Department of Laboratory Medicine, Faculty of Medicine, University of Tokyo, Tokyo.
Kano
Rui
R
Department of Pathobiology, School of Veterinary Medicine, Nihon University, Kanagawa. kano@brs.nihon-u.ac.jp.
Tsujimoto
Hajime
H
Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan.
Hasegawa
Atsuhiko
A
Department of Pathobiology, School of Veterinary Medicine, Nihon University, Kanagawa.
D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology; D002371:Cat Diseases / Q000209:etiology* / Q000473:pathology*; D002415:Cats; D008297:Male; D009190:Myelodysplastic Syndromes / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D023461:Myeloid Progenitor Cells; D014411:Neoplastic Stem Cells / Q000473:pathology*; D014410:Tumor Stem Cell Assay