[Pregnancy of patients conceived within one year after chemotherapy for gestational trophoblastic tumor].
OBJECTIVE
To explore the risk of pregnancy in patients conceived within one year after successful chemotherapy for gestational trophoblastic tumor.


METHODS
22 patients conceived within one year after chemotherapy were followed up and analysed about abnormal pregnant result, wastage rate and the time of interval between chemotherapy and pregnancy.


RESULTS
Among 22 cases, 9 cases were full term birth, 6 cases were wastage. The wastage rate was 27.3%. The wastage rate of these patients conceived within half a year was higher than one year (P < 0.05). 1 repeated hydatidiform mole and one post term choriocarcinoma occurred in 22 patients. They both were conceived within 5 months after chemotherapy.


CONCLUSIONS
Preservation of fertility is feasible in patients suffering from choriocarcimona and invasive mole. But these patients should practise contraception at least half a year after chemotherapy, and it's better to advise patients to take contraception for one year.
Zhu
L
L
Peking Union Medical College, Beijing 100730.
Yang
X
X
Song
H
H
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002822:Choriocarcinoma / Q000188:drug therapy*; D003609:Dactinomycin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000188:drug therapy*; D011247:Pregnancy / Q000187:drug effects*; D011256:Pregnancy Outcome; D014594:Uterine Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D003609:Dactinomycin; D005472:Fluorouracil