title: Biparental contribution to fetal thrombophilia in discordant twin intrauterine growth restriction.
abstract: Poor pregnancy outcomes have been reported to be associated with maternal thrombophilia. We present a case where 1 dizygotic twin inherited thrombophilic genes from both the father and mother, resulting in placental fetal thrombotic vasculopathy and intrauterine growth restriction, whereas its co-twin inherited only 1 such gene from its mother and was unaffected.
authors.affiliation: Department of Histopathology, Women's and Children's Hospital, 72 King William Road, North Adelaide SA 5006, Australia. yee.khong@adelaide.edu.au
authors.forename: T Y
authors.initials: TY
authors.lastname: Khong
authors.forename: W M
authors.initials: WM
authors.lastname: Hague
mesh_terms: D004200:Diseases in Twins; D005220:Fathers; D005260:Female; D005315:Fetal Diseases / Q000235:genetics* / Q000473:pathology; D005317:Fetal Growth Retardation / Q000235:genetics*; D005865:Gestational Age; D006579:Heterozygote; D006801:Humans; D008297:Male; D042965:Methylenetetrahydrofolate Reductase (NADPH2); D009035:Mothers; D009154:Mutation; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000235:genetics; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D019851:Thrombophilia / Q000235:genetics*; D013927:Thrombosis / Q000473:pathology; D014429:Twins, Dizygotic
chemical_list: D000587:Oxidoreductases Acting on CH-NH Group Donors; D042965:Methylenetetrahydrofolate Reductase (NADPH2)