[Salvia Miltiorrhizae Composita in preventing PaO2 lowering induced by controlled hypotension with nitroglycerin].
OBJECTIVE
To observe the effects of Salvia Miltiorrhizae Composita (SMC) on blood gas variations of nitroglycerin (NTG) controlled hypotension.


METHODS
Sixteen patients who were arranged to undergo operation under general anesthesia in controlled hypotension condition were divided randomly into control group (n = 8) and SMC group (treated group, n = 8), NTG were used to create controlled hypotension in both groups and blood pressure decrease about 30% comparing with the control values. Patients in the treated group were administered intravenously with SMC (16 ml) before the utilization of NTG.


RESULTS
Significant PaO2 decrease and Pa-etCO2 increase were observed in the control group during the controlled hypotension period. However, blood gas values in the treated group did not evidently change.


CONCLUSIONS
It suggested that SMC can prevent the side effects of NTG on blood gas.
Zheng
L
L
Department of Anesthesiology, First Affiliated Hospital of Hubei Medical University, Wuhan 430060.
Hu
L
L
Chen
X
X
D000328:Adult; D001785:Blood Gas Monitoring, Transcutaneous; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007023:Hypotension, Controlled; D008297:Male; D005996:Nitroglycerin / Q000009:adverse effects*; D010100:Oxygen / Q000378:metabolism; D010936:Plant Extracts; D027561:Salvia miltiorrhiza
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D005996:Nitroglycerin; D010100:Oxygen