title: Decreasing incidence of sudden death due to undiagnosed primary central nervous system tumors.
abstract: BACKGROUND
  Although most fatal brain tumors are diagnosed well before a patient's death, occasionally medical examiners and coroners encounter cases in which the presence of a primary tumor of the central nervous system (CNS) was not suspected prior to death. Analysis of such cases can shed light on specific pitfalls hindering the diagnosis of brain tumors. In addition, by analyzing the incidence of these cases in a large autopsy series, one can draw conclusions about the evolving effectiveness of medical diagnosis.
  
  
  OBJECTIVE
  To determine the incidence of deaths due to undiagnosed primary CNS tumors in the era of advanced neuroimaging techniques.
  
  
  METHODS
  Records from forensic autopsies performed during a 20-year period (1980-1999) at the Office of the Chief Medical Examiner of the State of Maryland were reviewed to identify cases in which death was caused by primary CNS tumors undiagnosed prior to the patient's death.
  
  
  RESULTS
  We present 11 cases of undiagnosed primary CNS tumors resulting in sudden death that were identified among 54 873 forensic autopsies. Sudden deaths due to undiagnosed CNS neoplasms account for a significantly lower percentage of cases in our study (0.02%) than in similar series reported prior to 1980 (> or =0.16%).
  
  
  CONCLUSIONS
  We hypothesize that improvements in imaging techniques, notably the introduction of computed tomography and magnetic resonance imaging, have resulted in increased early detection of CNS neoplasms. However, vague or short-term symptoms and limited health care access can dissuade patients from seeking medical attention and result in failure to diagnose these tumors correctly.
authors.affiliation: Department of Pathology, Johns Hopkins University School of Medicine, 720 Rutland Ave., Baltimore, MD 21205-2196, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Eberhart
authors.forename: A
authors.initials: A
authors.lastname: Morrison
authors.forename: K A
authors.initials: KA
authors.lastname: Gyure
authors.forename: J
authors.initials: J
authors.lastname: Frazier
authors.forename: J E
authors.initials: JE
authors.lastname: Smialek
authors.forename: J C
authors.initials: JC
authors.lastname: Troncoso
mesh_terms: D000328:Adult; D000368:Aged; D001344:Autopsy; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000473:pathology; D003952:Diagnostic Imaging; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013120:Spinal Cord Neoplasms / Q000175:diagnosis* / Q000473:pathology