Mycobacterial spindle cell pseudotumor of the appendix vermiformis in a patient with aids.
Mycobacterial pseudotumor (MP) is a rare pathologic presentation of both Mycobacterium tuberculosis and non-tuberculous mycobacterial disease, hitherto reported to occur only in immunosuppressed patients with or without human immunodeficiency virus infection. This lesion shares close pathologic resemblance to certain mesenchymal neoplasms, particularly Kaposi's sarcoma (KS), from which it must be properly differentiated due to distinct prognosis and therapy. We report a case of MP obliterating the lumen of the appendix vermiformis in a 34-year-old patient who died of complications of AIDS at our hospital in Rio de Janeiro. A total of 24 cases of MP (including our patient) have been described in the literature. MP has been found especially in lymph nodes, but extranodal lesions have been described in the skin, spleen, lung, bone marrow, brain and, in our patient, the appendix vermiformis. We offer a review of the other 23 published case reports of MP in both HIV-infected and uninfected patients and discuss the pathologic features that differentiate MP from KS.
Basilio-de-Oliveira
C
C
Departments of Pathology and Clinical Immunology, Gaffré e Guinle University Hospital, Rio de Janeiro, RJ, Brazil.
Eyer-Silva
W A
WA
Valle
H A
HA
Rodrigues
A L
AL
Pinheiro Pimentel
A L
AL
Morais-De-Sá
C A
CA
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D000328:Adult; D001065:Appendix / Q000382:microbiology*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D016867:Immunocompromised Host; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D015270:Mycobacterium avium-intracellulare Infection / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology; D012514:Sarcoma, Kaposi / Q000175:diagnosis* / Q000382:microbiology / Q000473:pathology