[Expression of c-fos in the medulla oblongata after carotid baroreceptor activation by elevated intrasinus pressure and adenosine].
Expression of c-fos protein in the medulla oblongata after baroreceptor activation by elevated intrasinus pressure (ISP) and perfusion of adenosine (Ado) was examined in 14 vascularly isolated carotid sinus perfusion rats. The results showed that Fos-like immunoreactive (FLI) neurons were distributed throughout nucleus tractus solitarius, area postrema, rostral ventrolateral medulla and nucleus raphe pallidus, and the number of FLI was increased with the elevation of ISP. Furthermore, perfusing the carotid sinus with Ado at a given ISP markedly increased the FLI in the above regions. From the results obtained, it is concluded that the c-fos expression in baroreflex pathway in medulla oblongata may be enhanced by elevated ISP and intrasinus perfusion of Ado, and Ado is capable of facilitating the baroreflex.
Chen
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S
Department of Physiology, Hebei Medical University, Shijiazhuang 050017.
Zhang
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Shi
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GM
He
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RR
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002346:Carotid Sinus / Q000502:physiology*; D066298:In Vitro Techniques; D008526:Medulla Oblongata / Q000378:metabolism*; D010477:Perfusion; D011311:Pressoreceptors / Q000502:physiology*; D011312:Pressure; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley
D016760:Proto-Oncogene Proteins c-fos; D000241:Adenosine