Enhanced reinnervation of the paralyzed orbicularis oculi muscle after insulin-like growth factor-I (IGF-I) delivery to a nerve graft.
Facial paralysis (FP) remains today one of the most disturbing cranial nerve disorders. The present study utilized the rat model of FP and examined a dual approach of combining the current microsurgical treatment of cross-facial nerve graft (CFNG) with local administration of insulin-like growth factor-I (IGF-I). The efficacy of this combined treatment approach was assessed by motor end-plate analysis of the reinnervated orbicularis oculi muscle (OOM). Local administration of IGF-I (50 microg/ml) to the CFNG demonstrated a 61 percent increase in the number of end-plates in the reinnervated OOMs, compared to the OOMs reinnervated with CFNG plus vehicle. These results indicate that the local therapeutic augmentation of IGF-I levels at the coaptation site(s) of the CFNG may, in fact, enhance reinnervation of muscle and recovery of function in general.
Thanos
P K
PK
Department of Neuroscience, State University of New York at Stony Brook, USA.
Tiangco
D A
DA
Terzis
J K
JK
D000818:Animals; D001767:Blinking / Q000502:physiology; D003131:Combined Modality Therapy; D004195:Disease Models, Animal; D005154:Facial Nerve / Q000503:physiopathology / Q000637:transplantation*; D007334:Insulin-Like Growth Factor I / Q000627:therapeutic use*; D008297:Male; D008866:Microsurgery; D009045:Motor Endplate / Q000503:physiopathology; D009801:Oculomotor Muscles / Q000294:innervation* / Q000503:physiopathology / Q000601:surgery*; D015840:Oculomotor Nerve Diseases / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D020127:Recovery of Function / Q000502:physiology
D007334:Insulin-Like Growth Factor I