title: Cancer research 2000: drug resistance, new targets and drugs in development.
abstract: The 91st Annual Meeting of the American Association for Cancer Research (AACR) provided the latest developments in cancer research. We highlight here presentations on resistance mechanisms (tumor microenvironment, efflux pumps, apoptosis), new targets and drugs in development (signal transduction, cell cycle, apoptosis, microtubules, topoisomerases) and new technologies (the cancer genome anatomy project, the human genome project, proteomics). The importance of signaling pathways or networks ('cell context') in defining the role of particular proteins was brought up in several presentations. A summary of specific drugs in development is also included in this report. Copyright 2000 Harcourt Publishers Ltd.
authors.affiliation: Department of Medical Oncology, Academic Hospital Vrije Universiteit, Amsterdam, The Netherlands
authors.forename: Henk J.
authors.initials: HJ
authors.lastname: Broxterman
authors.forename: Nafsika
authors.initials: N
authors.lastname: Georgopapadakou