title: Aspergillus spinal epidural abscess.
abstract: Spinal abscess due to Aspergillus is rare. A young boy with chronic granulomatous disease and aspergillosis of the rib had been treated with antifungal treatment 3 months earlier. The patient presented with a brief history of progressive paraparesis. Imaging showed D9--11 vertebral involvement and destruction of the D10 vertebral body with angulation and a large dorsally placed, multiloculated epidural abscess extending from D6 to L2. There was also extensive granulation anterior to and on either side of the vertebrae. The patient underwent extensive laminectomy and decompression of all the loculi and partial removal of the granulation tissue. Aggressive medical treatment was started. The authors recommend an aggressive surgical and medical approach in such cases of disseminated invasive aspergillosis, even though the result may not be very satisfactory. This report discusses the full clinical profile and management of Aspergillus spinal epidural abscess and emphasizes the need to follow up these cases to detect recurrence and new lesions, even if the patients are on adequate medical treatment. In spite of all efforts, high morbidity and mortality is common in such patients.
authors.affiliation: Department of Neurosurgery, Khoula Hospital, Muscat, Sultanate of Oman. kratika@omantel.net.om
authors.forename: P K
authors.initials: PK
authors.lastname: Gupta
authors.forename: A K
authors.initials: AK
authors.lastname: Mahapatra
authors.forename: R
authors.initials: R
authors.lastname: Gaind
authors.forename: S
authors.initials: S
authors.lastname: Bhandari
authors.forename: M M
authors.initials: MM
authors.lastname: Musa
authors.forename: S D
authors.initials: SD
authors.lastname: Lad
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000382:microbiology*; D001234:Aspergillus niger / Q000302:isolation & purification*; D002648:Child; D003131:Combined Modality Therapy; D020802:Epidural Abscess / Q000175:diagnosis / Q000382:microbiology* / Q000628:therapy; D006105:Granulomatous Disease, Chronic / Q000175:diagnosis / Q000601:surgery; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D007796:Laminectomy / Q000379:methods; D008279:Magnetic Resonance Imaging; D008297:Male; D013904:Thoracic Vertebrae / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole