title: Radioguided-surgery of early breast lesions.
abstract: BACKGROUND
  Radioguided-surgery has been recently proposed in patients with clinically occult breast lesions. This study aimed to evaluate the feasibility of correctly locating and eradicating, by a single intralesional injection of a radiotracer, any breast lesion and, in the case of malignancy, to perform simultaneous sentinel lymph node (SLN) biopsy procedure.
  
  
  METHODS
  Sixty-three women with early breast lesions were enrolled: 42 were invasive carcinomas, 16 in situ ductal carcinomas (DCIS) and 5 fibroadenomas.
  
  
  RESULTS
  Scintigraphic images clearly identified the lesions in all patients while SLN/s were evident in 88% of them. At surgery all the breast lesions were easily radiolocalized and eradicated with minimum surgical trauma and, for those patients with invasive carcinomas, the SLN technique was performed in 86% of them. No skip metastases were found.
  
  
  CONCLUSIONS
  A single intralesional administration of radiotracer is an easy and reliable procedure to simultaneously locate and remove both the non-palpable breast lesion and the SLN when primary malignancy was intraoperatively confirmed.
authors.affiliation: Clinical Surgery, University of Rome Tor Vergata, S. Eugenio Hospital, Italy.
authors.forename: O
authors.initials: O
authors.lastname: Buonomo
authors.forename: A
authors.initials: A
authors.lastname: Cabassi
authors.forename: F
authors.initials: F
authors.lastname: Guadagni
authors.forename: A
authors.initials: A
authors.lastname: Piazza
authors.forename: A
authors.initials: A
authors.lastname: Felici
authors.forename: R
authors.initials: R
authors.lastname: Piccirillo
authors.forename: G P
authors.initials: GP
authors.lastname: Atzei
authors.forename: C
authors.initials: C
authors.lastname: Cipriani
authors.forename: S
authors.initials: S
authors.lastname: Schiaroli
authors.forename: S
authors.initials: S
authors.lastname: Mariotti
authors.forename: M N
authors.initials: MN
authors.lastname: Guazzaroni
authors.forename: E
authors.initials: E
authors.lastname: Cossu
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
authors.forename: E
authors.initials: E
authors.lastname: Pernazza
authors.forename: C U
authors.initials: CU
authors.lastname: Casciani
authors.forename: M
authors.initials: M
authors.lastname: Roselli
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000601:surgery*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008198:Lymph Nodes / Q000601:surgery; D015412:Mastectomy, Segmental / Q000379:methods; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals / Q000627:therapeutic use*; D021701:Sentinel Lymph Node Biopsy; D013668:Technetium Tc 99m Aggregated Albumin / Q000627:therapeutic use*
chemical_list: D019275:Radiopharmaceuticals; D013668:Technetium Tc 99m Aggregated Albumin; C083602:technetium Tc 99m nanocolloid