Sterol-regulatory-element-binding protein 1c mediates insulin action on hepatic gene expression.
Effects of insulin on the expression of liver-specific genes are part of the adaptive mechanisms aimed at maintaining energy homeostasis in mammals. When the diet is rich in carbohydrates, secreted insulin stimulates the expression of genes for enzymes involved in glucose utilization (glucokinase, L-type pyruvate kinase and lipogenic enzymes) and inhibits genes for enzymes involved in glucose production (phosphenolpyruvate carboxykinase). The mechanisms by which insulin controls the expression of these genes have been poorly understood. Recently, the transcription factor sterol-regulatory-element-binding protein 1c has been proposed as a key mediator of insulin transcriptional effects. Here we review the evidence that has led to this proposal and the consequences for our understanding of insulin effects in physiological or pathological conditions.
Ferré
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INSERM Unit 465, Centre de Recherches Biomédicales des Cordeliers, Université Paris VI, 15, rue de l'Ecole de Médecine, 75270, Paris Cedex 06, France. pferre@bhdc.jussieu.fr
Foretz
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Azzout-Marniche
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Bécard
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Foufelle
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D000818:Animals; D022762:CCAAT-Enhancer-Binding Proteins / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004734:Energy Metabolism; D005786:Gene Expression Regulation / Q000187:drug effects*; D005934:Glucagon / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006706:Homeostasis / Q000187:drug effects; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008322:Mammals; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors / Q000378:metabolism
D022762:CCAAT-Enhancer-Binding Proteins; D004268:DNA-Binding Proteins; D007328:Insulin; D051780:Sterol Regulatory Element Binding Protein 1; D014157:Transcription Factors; D005934:Glucagon; D005947:Glucose