title: The effect of salinomycin on health status and performance of sows and their litters: a dose titration study.
abstract: Two hundred and fifty gilts and sows (Dalland parent stock) were divided randomly and allocated into the following five experimental groups: SAL0 = negative controls, SAL20 = 20 mg salinomycin per kg of feed, SAL40 = 40 mg salinomycin per kg of feed, SAL60 = 60 mg salinomycin per kg of feed and SAL80 = 80 mg salinomycin per kg of feed. Each gilt and sow was allocated to one of the five groups after the confirmation of the pregnancy using the ultrasonic method and remained under treatment for two consecutive breeding cycles. Throughout the experimental period several parameters related to sow health status, performance and fertility, as well as to health status and performance of their litters were recorded and calculated. Results indicated that salinomycin improves most of the parameters examined, as it leads to significantly higher (P < 0.05): (i) sow body weight gain during gestation; (ii) number of piglets born alive and weaned; (iii) piglet body weight at birth and at weaning, as well as to significantly lower (P < 0.05): (i) prevalence of thin sow syndrome at weaning; (ii) sow body weight loss during lactation; (iii) weaning-to-oestrus interval; (iv) piglet diarrhoea score during lactation; and (v) preweaning mortality. The best results were obtained at the inclusion levels of 40 and 60 mg salinomycin per kg of feed.
authors.affiliation: Clinic of Productive Animal Medicine, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54006 Thessaloniki, Macedonia, Greece.
authors.forename: C G
authors.initials: CG
authors.lastname: Giannakopoulos
authors.forename: S C
authors.initials: SC
authors.lastname: Kyriakis
authors.forename: K
authors.initials: K
authors.lastname: Saoulidis
authors.forename: A
authors.initials: A
authors.lastname: Spais
authors.forename: V
authors.initials: V
authors.lastname: Vassilopoulos
authors.forename: C
authors.initials: C
authors.lastname: Alexopoulos
mesh_terms: D000821:Animal Feed; D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019587:Dietary Supplements; D004305:Dose-Response Relationship, Drug; D005260:Female; D006304:Health Status; D008098:Litter Size; D011247:Pregnancy; D011714:Pyrans / Q000008:administration & dosage*; D013552:Swine; D013553:Swine Diseases / Q000517:prevention & control*; D000095662:Polyether Polyketides
chemical_list: D000900:Anti-Bacterial Agents; D011714:Pyrans; C010327:salinomycin; D000095662:Polyether Polyketides