title: The role of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and regulated on activation, normal T-cell expressed and secreted (RANTES) in the relationship between air pollution and asthma among children.
abstract: To evaluate the role of adhesion molecules and chemokines in the relationship between air pollution and asthma, the authors determined the following in 230 children who lived in 4 communities in Japan that had different levels of air pollution: serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1); soluble vascular cell adhesion molecule-1 (sVCAM-1); regulated on activation, normal T-cell expressed and secreted (RANTES); and total immunoglobulin E (IgE). Children with asthma or who exhibited wheezing (n = 115) and nonasthmatic children (n = 115) were studied. Serum concentrations of sICAM-1, sVCAM-1, and RANTES were increased significantly in asthmatic children, compared with nonasthmatic children. Nonasthmatic children with serum IgE levels that were greater than or equal to 250 IU/ml had significantly lower concentrations of sICAM-1 and sVCAM-1 than the other children. The geometric means of sICAM-1 increased as air pollution increased. The results of this study suggest that adhesion molecules or chemokines are associated with asthma and that ICAM-1 may play an important role in the relationship between air pollution and the occurrence of asthma.
authors.affiliation: Department of Public Health, Chiba University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Ando
authors.forename: M
authors.initials: M
authors.lastname: Shima
authors.forename: M
authors.initials: M
authors.lastname: Adachi
authors.forename: Y
authors.initials: Y
authors.lastname: Tsunetoshi
mesh_terms: D000393:Air Pollutants / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects*; D001249:Asthma / Q000097:blood / Q000453:epidemiology* / Q000209:etiology* / Q000276:immunology; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007564:Japan / Q000453:epidemiology; D008297:Male; D009585:Nitrogen Dioxide / Q000032:analysis; D010316:Particle Size; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
chemical_list: D000393:Air Pollutants; D018946:Chemokine CCL5; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D007073:Immunoglobulin E; D009585:Nitrogen Dioxide