The anti-tumour effect of Klebsiella pneumoniae capsular polysaccharides.
K24 capsular polysaccharide (K24-CPS), with a known structure of a repeating unit, was isolated from the capsule of Klebsiella pneumoniae serotype K24. The polysaccharide was found to suppress the proliferation of Ehrlich ascites tumour (EAT) cells in vitro, but did not alter the cell cycle distribution of cells. K24-CPS treatment reduced the tyrosine phosphorylation of some proteins in EAT cells. Furthermore, the treatment also decreased the expression of c-JUN, but had no effect on the levels of c-FOS and c-MYC. It is speculated that the growth suppression effect of K24-CPS may be related to its effect in down-regulating c-JUN expression.
Kwok
T T
TT
Department of Biochemistry, The Chinese University of Hong Kong. Hong Kong.
Chen
P
P
Liu
P Y
PY
Tang
Y C
YC
Kong
S K
SK
Fung
K P
KP
Choy
Y M
YM
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D016667:Bacterial Capsules; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D002453:Cell Cycle / Q000187:drug effects; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D016758:Genes, jun; D007711:Klebsiella pneumoniae / Q000737:chemistry*; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics; D010766:Phosphorylation / Q000187:drug effects; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011499:Protein Processing, Post-Translational / Q000187:drug effects; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis; D015398:Signal Transduction / Q000187:drug effects; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000970:Antineoplastic Agents; D009363:Neoplasm Proteins; D011135:Polysaccharides, Bacterial; D016755:Proto-Oncogene Proteins c-jun; C437547:capsular polysaccharide K24