Neutrophil-related host response in hidradenitis suppurativa: a pilot study in patients with inactive disease.
Host-defence defects in hidradenitis suppurativa patients have been suspected, but not proven. Activated neutrophils can destroy the surrounding tissues by a release of reactive oxygen species and active proteases. Peripheral neutrophils from 15 female patients (mean age 46, range 27-57 years) in an inactive state of their hidradenitis suppurativa, were studied and compared with 15 age-matched healthy female controls. There were no significant differences between patients and controls in the assessments of intracellular elastase activity, total content of antigenic elastase or release of elastase. Furthermore, no differences were found in total content and membrane expression of the receptors measured. The generation of free oxygen radicals, after stimulation with the protein kinase C activator phorbol myristate acetate, was significantly higher in the patients than in the controls, while there was no difference after Fc-receptor-mediated stimulation. Dysfunctional neutrophils might be involved in the pathogenesis of hidradenitis suppurativa, but the findings should be interpreted with caution because of the small number of observed cases.
Lapins
J
J
Department of Medicine, Karolinska Institutet at Huddinge University Hospital, Stockholm, Sweden. jan.lapins@dermat.hs.sll.se
Asman
B
B
Gustafsson
A
A
Bergström
K
K
Emtestam
L
L
D000328:Adult; D015703:Antigens, CD / Q000378:metabolism; D015415:Biomarkers; D016022:Case-Control Studies; D005260:Female; D005609:Free Radicals / Q000378:metabolism; D058851:GPI-Linked Proteins; D017497:Hidradenitis Suppurativa / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D010196:Pancreatic Elastase / Q000378:metabolism*; D010865:Pilot Projects; D017452:Receptors, IgG / Q000378:metabolism
D015703:Antigens, CD; D015415:Biomarkers; C428200:FCGR3B protein, human; D005609:Free Radicals; D058851:GPI-Linked Proteins; D017452:Receptors, IgG; D010196:Pancreatic Elastase