Influence of midluteal serum prolactin on outcome of pregnancy after IVF-ET: a preliminary study.
OBJECTIVE
To investigate the relationship between serum prolactin levels in the midluteal phase and the prognosis of pregnancy after IVF-ET.


METHODS



METHODS
Prospective study;


METHODS
Shimane Medical University Hospital;


METHODS
29 patients completing their 34th IVF cycle; and


METHODS
Serum levels of prolactin, estradiol-17 beta, and progesterone in the midluteal phase.


RESULTS
Midluteal prolactin levels were significantly lower in patients with early pregnancy loss than in the successful pregnancy group. The mean progesterone/prolactin ratio and the estradiol-17 beta/prolactin ratio were highest in patients with early pregnancy loss and were lowest in patients with successful pregnancies.


CONCLUSIONS
Findings of this study suggest that measurement of the serum prolactin concentration in the midluteal phase is useful for predicting the outcome of IVF-ET.
Ozaki
T
T
Department of Obstetrics and Gynecology, Shimane Medical University, 89-1, Enya-cho, Izumo 693-8501, Japan.
Takahashi
K
K
Kurioka
H
H
Miyazaki
K
K
D000328:Adult; D004624:Embryo Transfer; D004967:Estrogens / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D012739:Gonadal Steroid Hormones / Q000097:blood; D006801:Humans; D007247:Infertility, Female / Q000097:blood*; D008183:Luteal Phase / Q000097:blood*; D011247:Pregnancy; D011256:Pregnancy Outcome; D011374:Progesterone / Q000097:blood; D011379:Prognosis; D011388:Prolactin / Q000097:blood / Q000502:physiology*; D011446:Prospective Studies; D013480:Superovulation / Q000097:blood
D004967:Estrogens; D012739:Gonadal Steroid Hormones; D011374:Progesterone; D011388:Prolactin