title: Preliminary study of the deposition of aerosol in the maxillary sinuses using a plastinated model.
abstract: In spite of the widespread use of aerosols in respiratory diseases, very few studies have been performed in the field of ear, nose, and throat (ENT) disorders. The conditions for penetration of aerosols inside the sinus cavities are thus still not understood fully. The aim of this study was to investigate the penetration of aerosols inside maxillary sinuses in vitro, using plastinated models. Three plastinated specimens of the nose and sinuses were made from three different corpses. These specimens were validated by CT scans and were used to study deposition of aerosol in the maxillary sinuses. We performed scintigraphic images of the models in above, face, and profile views using a technetium (99mTc)-labelled solution to show aerosol deposition. We also counted the radioactivity deposited on gauze compresses placed inside the maxillary sinuses. In addition, we constructed a measuring unit with miniature humidity sensors placed inside the sinuses. We recorded the changes in relative humidity observed during nebulization. Results from these studies showed that scintigraphic images of the specimen, whatever the incidence of the views, were not accurate enough to differentiate the aerosol deposition in the maxillary sinuses from that in the nasal cavity. Using indirect counting on gauze compresses made possible the quantification of local aerosol deposition, and we found that aerosols entered into the sinuses. This confirmed that aerosols could reach the middle meatus, which is the main area for sinusitis disorders. The increased activity compared to background varied from 17 to 127%. The humidity sensors recorded changes in relative humidity during the nebulization. These humidity changes fitted a nonlinear model represented by the equation: y = b0 (1 - e(-b1t)), where b0 is the plateau and b1 is the speed to reach the plateau. These techniques may be useful in the future for in vitro characterization of aerosol penetration into the maxillary sinuses.
authors.affiliation: Service d'ORL et de Chirurgie Cervico-Faciale, CHU Saint-Etienne, France. marc.durand@univ-st-etienne.fr
authors.forename: M
authors.initials: M
authors.lastname: Durand
authors.forename: P
authors.initials: P
authors.lastname: Rusch
authors.forename: D
authors.initials: D
authors.lastname: Granjon
authors.forename: G
authors.initials: G
authors.lastname: Chantrel
authors.forename: J M
authors.initials: JM
authors.lastname: Prades
authors.forename: F
authors.initials: F
authors.lastname: Dubois
authors.forename: D
authors.initials: D
authors.lastname: Esteve
authors.forename: J F
authors.initials: JF
authors.lastname: Pouget
authors.forename: C
authors.initials: C
authors.lastname: Martin
mesh_terms: D000336:Aerosols / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001682:Biological Availability; D002102:Cadaver; D006801:Humans; D008443:Maxillary Sinus / Q000000981:diagnostic imaging / Q000378:metabolism*; D008954:Models, Biological; D009296:Nasal Cavity / Q000000981:diagnostic imaging / Q000378:metabolism*; D009330:Nebulizers and Vaporizers; D010316:Particle Size; D011877:Radionuclide Imaging; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity
chemical_list: D000336:Aerosols