Pediatric stem cell transplantation and critical care (an outcome evaluation).
This paper reviews eight published studies of children who required critical care following a stem cell transplant. Approximately 14% of children required mechanical ventilation following stem cell transplant. Sixteen percent of these children survived. Eleven percent of children who had primary lung injury secondary to either infectious or non-infectious causes survived. Patients with respiratory failure induced by disease in organ systems other than the lungs had much better survival (33-39%). Children reported to have a non-bacterial infectious lung disease had very poor survival. Children who developed multi-organ system failure (MOSF) in addition to lung disease also had poor survival. The majority of children died of MOSF or pulmonary failure.
Gale
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Cardinal Glennon Children's Hospital, 1465 S. Grand, St. Louis, MO 63104, USA.
D002648:Child; D003422:Critical Care; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects* / Q000401:mortality; D006801:Humans; D008171:Lung Diseases / Q000209:etiology; D006435:Renal Dialysis; D012121:Respiration, Artificial; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy; D012307:Risk Factors; D016896:Treatment Outcome