Effectiveness of porto-intracaval shunt to reduce the negative effects of portal and caval clamping in the rabbit.
In performing experimental liver surgery, it is difficult to prolong anhepatic time because the animals do not tolerate prolonged portal and caval clamping. To counteract prolonged venous stasis, the authors previously developed a simple porto-intracaval shunt. The shunt consists of a self-constructed inverted Y silicone tube. The effectiveness of this shunt was studied comparing two groups of 10 rabbits with shunt (S) versus those with clamped portal and inferior caval vein (C). In the group of rabbits that underwent porto-intracaval shunt, the results concerning intraoperative mortality, intraoperative increase in distal portal vein pressure, and incidence of the histologic signs of gut damage were clearly improved. The proposed porto-intracaval shunt was therefore effective in reducing some principal negative effects of portal and caval clamping. This type of porto-intracaval shunt can be therefore useful allowing improvement of experimental models concerning liver surgery in little animals.
La Greca
G
G
First Surgical Clinic, University of Catania, Policlinico and Ospedale Cannizzaro, 95128 Catania, Italy. glagreca@mbox.unict.it
Astuto
M
M
Randazzo
V
V
Latteri
S
S
Lanteri
R
R
Puleo
S
S
D000818:Animals; D002408:Catheters, Indwelling; D004195:Disease Models, Animal; D007422:Intestines / Q000098:blood supply / Q000473:pathology; D007511:Ischemia / Q000473:pathology; D008099:Liver / Q000098:blood supply / Q000601:surgery*; D008297:Male; D008866:Microsurgery / Q000295:instrumentation*; D011167:Portacaval Shunt, Surgical / Q000295:instrumentation*; D017082:Portal Pressure / Q000502:physiology; D011817:Rabbits; D012828:Silicones; D013525:Surgical Instruments
D012828:Silicones