[Clinical and experimental study on Fuzheng Baozhen Decoction enhancing effect of radio- and chemotherapy for malignant tumors].
OBJECTIVE
To study on Fuzheng Baozhen Decoction (FZBZD) enhancing effect of radio- and chemotherapy for malignant tumors.


METHODS
One hundred and Seventeen cases of malignant tumors treated with chemotherapy or/and radiotherapy, 55 cases treated together with FZBZD (group A), comparing with 30 cases treated with radio- and chemotherapy plus Zhenqi Fuzheng Granules (group B) and 32 cases radio- and chemotherapy alone (group C). Mechanism of FZBZD enhancing effect of chemotherapy on transplanted human lung adenocarcinoma (SPC-A-1) and sarcoma (S180) bearing mice was conducted.


RESULTS
Effective rates (CR + PR) of group A, B, C were 63.6%, 43.3%, 37.5% respectively, that of group A was the best (P < 0.05). The survival quality of life was improved best in group A (P < 0.05). After being treated, the level of the peripheral blood (WBC, Hb, PLT) of group A was the highest (P < 0.05); CD3, CD4, NK activity, interleukin-2 were also improved significantly in group A (P < 0.01). Animal experiment showed that FZBZD could improve chemotherapy effect of inhibitory action on tumor growth (P < 0.01), increase cAMP/cGMP ratio (P < 0.01) by adding cAMP level in cancer tissue, and enhance of G0/G1 phase cells and decrease S phase cells.


CONCLUSIONS
FZBZD inhibited tumor growth and enhanced the effect of radio- and chemotherapy by improving immune and hematopoietic function, cAMP/cGMP ratio and stagnating tumor cells in G0/G1 phase.
Li
J
J
Institute of Integrated Traditional Chinese and Western Medicine, Hunan Medical University, Changsha 410008.
Li
X
X
Li
J
J
D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004357:Drug Synergism; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy; D006410:Hematopoiesis / Q000187:drug effects; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000532:radiotherapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008875:Middle Aged; D009368:Neoplasm Transplantation; D011897:Random Allocation; D016176:T-Lymphocyte Subsets / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004365:Drugs, Chinese Herbal