title: Antibiotic prophylaxis for group A streptococcal burn wound infection is not necessary.
abstract: BACKGROUND
  Historically, group A beta-hemolytic streptococci (GAS) burn wound infection has been a major source of morbidity and mortality in burn patients and has prompted the prophylactic administration of antibiotics to children with burns. Wound monitoring, surveillance cultures, and early excision of deep wounds may have changed this. Our objective in this project was to determine the efficacy of routine antibiotic prophylaxis in the era of early excision and closure of deep burn wounds.
  
  
  METHODS
  Two cohorts of burned children were compared: all children admitted during calendar years 1992 through 1994 (group 1) and during calendar years 1995 through 1997 (group 2). All group 1 children received routine GAS antibiotic prophylaxis. Only those group 2 children with documented positive admission or surveillance cultures for GAS were treated.
  
  
  RESULTS
  There were 511 children in group 1 and 406 children in group 2. They were well matched for age (4.7 +/- 0.21 years vs. 5.3 +/- 0.26 years, p = 0.06) and burn size (11.0% +/- 0.7% vs. 12.4% +/- 0.8%, p = 0.18). GAS species were recovered at admission or during hospitalization from 11 (2.6%) of group 1 children and 18 (4.4%) of group 2 children (p = 0.05), indicating a marginally higher rate of carriage in group 2. Nevertheless, in group 1 there were three (0.6%) who developed GAS wound infection and in group 2 there were four (0.98%, p = 0.71). The incidence of GAS infection in those patients with positive admission cultures was three (27%) of group 1 and four (22%) of group 2. No child developed fulminant GAS infection.
  
  
  CONCLUSIONS
  Routine antibiotic prophylaxis of burn wounds in children in not effective in further reducing a low baseline incidence of GAS wound infection if admission screening by culture is used to identify those children who carry the organism and early excision of deep burns is practiced.
authors.affiliation: Shriners Burns Hospital, Massachusetts General Hospital, Boston 02114, USA. sheridan.robert@mgh.harvard.edu
authors.forename: R L
authors.initials: RL
authors.lastname: Sheridan
authors.forename: J M
authors.initials: JM
authors.lastname: Weber
authors.forename: M S
authors.initials: MS
authors.lastname: Pasternack
authors.forename: R G
authors.initials: RG
authors.lastname: Tompkins
mesh_terms: D000284:Administration, Oral; D019072:Antibiotic Prophylaxis; D002056:Burns / Q000601:surgery*; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007223:Infant; D007262:Infusions, Intravenous; D008297:Male; D010406:Penicillins / Q000008:administration & dosage*; D012189:Retrospective Studies; D013290:Streptococcal Infections / Q000517:prevention & control*; D013297:Streptococcus pyogenes / Q000187:drug effects*; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D010406:Penicillins