No effect of water deprivation for 48 hours on the pharmacokiinetics of intravenous tacrolimus in rats.
Because the physiological changes that occur in patients with water deprivation could alter the pharmacokinetics of drugs, the pharmacokinetics of tacrolimus were investigated after 1-min intravenous administration of the drug (1 mg/kg) to control rats and rats with water deprivation for 48 h. In rats with dehydration, kidney function seemed to be impaired slightly. Kidney weight (0.800 versus 0.676% body weight) increased significantly and the renal tissue showed only total and mild tubular dilatation and flattening of tubular epithelial cells based on kidney microscopy. However, hepatic function seemed not to be impaired in rats with dehydration. After intravenous administration of tacrolimus, the pharmacokinetic parameters were not significantly different between two groups of rats and the results were expected since tacrolimus was almost completely metabolized in rats (impaired kidney function could not affect considerably the pharmacokinetics of tacrolimus) and hepatic function was not impaired in rats with dehydration.
Son
I J
IJ
Department of Pharmacy, College of Pharmacy, Duksung Women's University, Tobong-Gu, Seoul, South Korea.
Moon
Y J
YJ
Lee
M G
MG
Sohn
Y T
YT
D000818:Animals; D007166:Immunosuppressive Agents / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D016559:Tacrolimus / Q000097:blood / Q000493:pharmacokinetics*; D014868:Water Deprivation
D007166:Immunosuppressive Agents; D016559:Tacrolimus