Clinical pathophysiology of hibernating myocardium.
Our current knowledge of the pathophysiology of chronic hibernating myocardium is mainly based on results from clinical studies, because of the absence of appropriate and validated animal models. These clinical observations have given rise to two major controversies: the role of reduced blood flow and that of histological changes in the hibernating segments. In this review, these two subjects will be briefly discussed, and put into the perspective of findings emerging from recently developed animal models.
Dispersyn
G D
GD
Department of Molecular Cell Biology, Cardiovascular Research Institute Maastricht, University of Maastricht, The Netherlands.
Ramaekers
F C
FC
Borgers
M
M
D000818:Animals; D001783:Blood Flow Velocity / Q000502:physiology; D002908:Chronic Disease; D006801:Humans; D017682:Myocardial Stunning / Q000503:physiopathology*