[Effects of synthetic peptides on ovarian cancer cells].
OBJECTIVE
To observe the effect of follicle-stimulating hormone(FSH) synthetic peptides(FSH binding Fragment), FSH and synthetic peptides on the proliferation of human epithelial ovarian cancer cell.


METHODS
Human epithelial ovarian cancer cells lines SKOV3, OVCAR, AO and 3AO were incubated with FSH, FSH binding fragment, FSH and the binding fragment respectively. The cell proliferation was detected by methyl thiazolyl tetrazolium (MTT) technique.


RESULTS
The rate of proliferation in the cancer cell was increased apparently as increasing in the concentration of FSH and the rate of proliferation average value 28.0%, and was decreased apparently as increasing in the concentration of the synthetic peptides and the rate of inhibition average value 8.3%. When the cell was expressed in FSH, the proliferation was decreased apparently as increasing in the concentration of the peptides and the rate of inhibition average valve 3.1%.


CONCLUSIONS
It is suggested that FSH binding fragment can inhibit the proliferation of ovarian cancer cell. The FSH binding fragment could be used as a binding part of anticancerous complex for ovarian cancer.
Zhou
K
K
Obstetrics and Gynecology Hospital, Shanghai Medical University, Shanghai 200011.
Zhu
M
M
Feng
Y
Y
D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology*; D010446:Peptide Fragments / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D010446:Peptide Fragments; D005640:Follicle Stimulating Hormone