PcrV immunization enhances survival of burned Pseudomonas aeruginosa-infected mice.
Burned Pseudomonas aeruginosa-infected mice immunized against PcrV, a type III virulence system translocating protein, showed significantly enhanced survival compared to controls. Survival was non-O serotype specific and correlated with a reduced systemic microbial load. Infection with a high-level toxin A-producing strain required supplemental antitoxin treatment to enhance survival.
Holder
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IA
Department of Microbiology, Shriners Hospital for Children, Cincinnati, Ohio 45229, USA. iaholder@juno.com
Neely
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Frank
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DW
D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D000992:Antitoxins / Q000008:administration & dosage / Q000276:immunology; D001427:Bacterial Toxins / Q000008:administration & dosage / Q000276:immunology*; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D002056:Burns / Q000150:complications*; D004195:Disease Models, Animal; D006801:Humans; D051379:Mice; D052899:Pore Forming Cytotoxic Proteins; D011552:Pseudomonas Infections / Q000276:immunology* / Q000401:mortality / Q000517:prevention & control / Q000628:therapy; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D014611:Vaccination
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000992:Antitoxins; D001427:Bacterial Toxins; D001428:Bacterial Vaccines; D052899:Pore Forming Cytotoxic Proteins; C118546:antigen V, Pseudomonas; C029294:toxin A (Pseudomonas)