title: [Spondylodiscitis due to Histoplasma duboisii. Report of two cases and review of the literature].
abstract: We report two cases of African histoplasmosis caused by Histoplasma duboisii located in the spine, on two Malian adults aged 40 and 47 years respectively. Clinical signs consisted of dorsal spinal syndrome in both cases and a paraplegia in one case. Radiography and CT scan revealed a spondylodiscitis without any bone reconstruction in both cases and a prevertebral abscess in one case. Diagnosis was confirmed by mycological and pathological examinations of surgical specimen which revealed Histoplasma duboisii fungus. Medical treatment, after surgical repair, consisted in ketoconazola with positive results after 12 months. This localisation is rare. It raises diagnosis problems with tuberculous spondylodiscitis because of their radio-clinical resemblance.
authors.affiliation: Service de Neurochirurgie, CHU de Yopougon, 21 BP 632, Abidjan 21, Côte-d'Ivoire, France.
authors.forename: D
authors.initials: D
authors.lastname: N'dri Oka
authors.forename: G
authors.initials: G
authors.lastname: Varlet
authors.forename: M
authors.initials: M
authors.lastname: Kakou
authors.forename: Y
authors.initials: Y
authors.lastname: Zunon-Kipre
authors.forename: E
authors.initials: E
authors.lastname: Broalet
authors.forename: V
authors.initials: V
authors.lastname: Ba Zeze
mesh_terms: D000038:Abscess / Q000000981:diagnostic imaging / Q000382:microbiology / Q000601:surgery; D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use; D015299:Discitis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology / Q000601:surgery*; D005260:Female; D006658:Histoplasma / Q000302:isolation & purification; D006660:Histoplasmosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006801:Humans; D007654:Ketoconazole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010264:Paraplegia / Q000209:etiology; D011859:Radiography
chemical_list: D000935:Antifungal Agents; D007654:Ketoconazole