[Experimental study in rabbit on repair of radial bone defect by bioactive degradable polymer].
OBJECTIVE
To investigate the availability of bone defect repair by degradable porous polycaprolactam (PCL) as the carrier of bone morphogenetic protein (BMP).


METHODS
Three different kinds of bone substitutes, including decalcified bone matrix, PCL-BMP compounds and simple PCL, were implanted into the radial bone defects in 36 rabbits, and in the other 12 rabbits the bone defects were left untreated as control. X-ray examination, X-ray morphometry, histological and electron microscopic observation were performed at different time after operation.


RESULTS
The quantity of new bone formation in PCL-BMP group was prior to that in simple PCL group. The pattern and speed of bone defect repair in PCL-BMP group were similar to those in decalcified bone matrix. Electron microscopic observation showed that the PCL-BMP group degraded faster than simple PCL group, which was more suitable for bone repair.


CONCLUSIONS
PCL is a good carrier of BMP with potential for clinical use.
Qi
X
X
Department of Orthopedic Surgery, Norman Bethune University of Medical Sciences, Changchun Jilin, P.R. China 130021.
Liu
J G
JG
Huang
L F
LF
D000818:Animals; D001673:Biodegradation, Environmental; D019485:Bone Morphogenetic Proteins / Q000378:metabolism / Q000494:pharmacology*; D001861:Bone Regeneration / Q000502:physiology; D018786:Bone Substitutes / Q000378:metabolism / Q000494:pharmacology*; D002209:Caprolactam / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D008297:Male; D011817:Rabbits; D011884:Radius / Q000293:injuries / Q000601:surgery*
D019485:Bone Morphogenetic Proteins; D018786:Bone Substitutes; D002209:Caprolactam; C000362:capron