title: [Intermittent administration of 5-FU and isovorin to patients with advanced and recurrent colon cancer].
abstract: We attempted a new regimen of intermittent administration of 5-FU and low-dose Isovorin (F.I) to four patients with advanced and recurrent colon cancer. A partial response (PR) was achieved in two of four patients who had evaluable lesions for this treatment. We observed few side effects among these patients. Only one patient among four showed grade 1 neuropathy after two administrations of this chemotherapy. However, after a two-week pause in administration, the neuropathy disappeared and we could continue the therapy. This patient with multiple liver metastases achieved a partial response. Other patients had no side effects such as bone marrow suppression or digestive symptoms. This intermittent F.I treatment might be an effective and promising therapy with few side effects even for patients with poorer conditions.
authors.affiliation: Dept. of Surgery II, Fukushima Medical University.
authors.forename: K
authors.initials: K
authors.lastname: Sekikawa
authors.forename: K
authors.initials: K
authors.lastname: Anzai
authors.forename: T
authors.initials: T
authors.lastname: Momma
authors.forename: T
authors.initials: T
authors.lastname: Yamaki
authors.forename: Y
authors.initials: Y
authors.lastname: Ando
authors.forename: M
authors.initials: M
authors.lastname: Sassa
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: Y
authors.initials: Y
authors.lastname: Endo
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Honda
authors.forename: Y
authors.initials: Y
authors.lastname: Hatakeyama
authors.forename: Y
authors.initials: Y
authors.lastname: Koyama
authors.forename: N
authors.initials: N
authors.lastname: Inoue
authors.forename: I
authors.initials: I
authors.lastname: Kimijima
authors.forename: S
authors.initials: S
authors.lastname: Takenoshita
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D002955:Leucovorin; D005472:Fluorouracil