Transformation of 2,2'-bimorphine to the novel compounds 10-alpha-S-monohydroxy-2,2'-bimorphine and 10,10'-alpha,alpha'-S,S'-dihydroxy-2,2'-bimorphine by Cylindrocarpon didymum.
Whole-cell suspensions of Cylindrocarpon didymum were observed to transform 2,2'-bimorphine to the compounds 10-alpha-S-monohydroxy-2,2'-bimorphine and 10,10'-alpha,alpha'-S,S'-dihydroxy-2,2'-bimorphine. Mass spectrometry and (1)H nuclear magnetic resonance spectroscopy confirmed the identities of these new morphine alkaloids.
Stabler
P J
PJ
Institute of Biotechnology, University of Cambridge, Cambridge CB2 1QT, United Kingdom.
Holt
P J
PJ
Bruce
N C
NC
D001203:Ascomycota / Q000378:metabolism*; D003061:Codeine / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D009020:Morphine / Q000378:metabolism; D009022:Morphine Derivatives / Q000378:metabolism*
C437395:DP584; C437396:DP600; D009022:Morphine Derivatives; D009020:Morphine; C009101:pseudomorphine; D003061:Codeine