[Epidemiological aspects of the genotype of hepatitis C virus].
OBJECTIVE
To research the epidemiological characteristics of genotype of hepatitis C virus.


METHODS
107 HCV isolates from 7 cities in southern, northern and northeast of China were analyzed using PCR and second generation line probe assay (INNO-LiPA).


RESULTS
The analysis of HCV genotypes showed that: 1. HCV l b was the common genotype (83 17%), however the frequency of genotype l b in northeast (72.22%) was lower than northern (87.65%, P <0.01), and the frequency of the genotype 2 was in low level (6.86%). The rate of coinfection with l b and other genotype was 10.29%. 2. The rate of infection with genotype l b in female patients was higher (93.61%) than that in male (75.0%) showing statistical significance (P <0.01). 3. In three age groups (< 30, 30 - 49 and > 50 years old) the rates of infection with genotype l b were 77.77%, 83.92% and 90.90%, respectively. 4. The detection rates of genotype l b in patients with infection period > 10 years and <10 years were 100% and 80.43% respectively (P <0.01).


CONCLUSIONS
There are some relationship between HCV genotype and HCV geographic distribution, sex, age and infection period of patients.
Xu
B
B
The Central Hospital of Jingan District, Shanghai 200040, China.
Lu
P
P
Zhu
M
M
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002681:China / Q000453:epidemiology; D015342:DNA Probes; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics* / Q000302:isolation & purification; D019698:Hepatitis C, Chronic / Q000453:epidemiology* / Q000635:transmission / Q000821:virology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D012737:Sex Factors
D015342:DNA Probes