title: Cutaneous signet ring cell carcinoma: a report of a case and review of the literature.
abstract: Primary cutaneous signet-ring cell carcinoma (CSRCC) is a very unusual but distinctive clinicopathologic entity. It is defined as a diffuse malignant epithelial neoplasia localized in dermis and subcutis without epidermal involvement, showing variable amounts of signet ring cells, without evidence of a visceral adenocarcinoma. We report a case of CSRCC in a 70-year-old man along with its histologic and ultrastructural characteristics, and review of previous cases. We describe their main diagnostic features and discuss its wide differential diagnosis.
authors.affiliation: Department of Pathology, University Hospital 12 de Octubre, Madrid, Spain.
authors.forename: C
authors.initials: C
authors.lastname: González-Lois
authors.forename: J L
authors.initials: JL
authors.lastname: Rodríguez-Peralto
authors.forename: R
authors.initials: R
authors.lastname: Serrano-Pardo
authors.forename: M A
authors.initials: MA
authors.lastname: Martínez-González
authors.forename: F
authors.initials: F
authors.lastname: López-Ríos
mesh_terms: D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*