title: Dynamic observation of pulmonary perfusion using continuous arterial spin-labeling in a pig model.
abstract: The continuous arterial spin-labeling (CASL) method of perfusion MRI is used to observe pulmonary perfusion dynamically in an animal model. Specifically, a respiratory-triggered implementation of the CASL method is used with approximate spatial resolution of 0.9 x 1.8 x 5.0 mm (0.008 cc) and 2-minute temporal resolution. Perfusion MRI is performed dynamically during repeated balloon occlusion of a segmental pulmonary artery, as well as during pharmacological stimulation. A total of three Yorkshire pigs were studied. The results demonstrate the ability of the endogenous spin-labeling method to characterize the dynamic changes in pulmonary perfusion that occur during important physiological alterations.
authors.affiliation: Department of Radiology, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania 19104-4283, USA. roberts@oasis.rad.upenn.edu
authors.forename: D A
authors.initials: DA
authors.lastname: Roberts
authors.forename: R R
authors.initials: RR
authors.lastname: Rizi
authors.forename: D A
authors.initials: DA
authors.lastname: Lipson
authors.forename: M A
authors.initials: MA
authors.lastname: Ferrante
authors.forename: L
authors.initials: L
authors.lastname: Bearn
authors.forename: L
authors.initials: L
authors.lastname: Rolf
authors.forename: J
authors.initials: J
authors.lastname: Baumgardner
authors.forename: A
authors.initials: A
authors.lastname: Yamomoto
authors.forename: H
authors.initials: H
authors.lastname: Hatabu
authors.forename: J
authors.initials: J
authors.lastname: Hansen-Flaschen
authors.forename: W B
authors.initials: WB
authors.lastname: Gefter
authors.forename: M D
authors.initials: MD
authors.lastname: Schnall
mesh_terms: D000818:Animals; D021721:Balloon Occlusion; D008168:Lung / Q000033:anatomy & histology*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D010477:Perfusion; D011651:Pulmonary Artery; D011652:Pulmonary Circulation; D013113:Spin Labels; D013552:Swine
chemical_list: D013113:Spin Labels