[The effects of IL-1 on synthesis of collagen in scar-derived fibroblasts].
OBJECTIVE
To investigate modulation of cytokines on biological activities of scar-derived fibroblasts.


METHODS
This study focused on the effects of interleukin-1 (IL-1) on collagen biosynthesis, nucleic acid, and cell organs of fibroblasts.


RESULTS
The results showed the IL-1 could reduce not only the collagen synthesis of fibroblasts, but also quantity of nucleic acid.


CONCLUSIONS
The authors confirm that IL-1 is a cytokine with down-regulation effect on scar formation, and suggest that IL-1 can play an important role in prevention and treatment of scar.
Yang
D
D
Department of Plastic Surgery, Nanfang Hospital, First Military Medical University, Guangzhou 510515.
Luo
J
J
Zhu
J
J
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002921:Cicatrix / Q000378:metabolism* / Q000473:pathology; D017439:Cicatrix, Hypertrophic / Q000378:metabolism* / Q000473:pathology; D003094:Collagen / Q000096:biosynthesis*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D009696:Nucleic Acids / Q000378:metabolism
D007375:Interleukin-1; D009696:Nucleic Acids; D003094:Collagen