[Familial articular chondrocalcinosis: study of an Alsatian family].
Familial articular chondrocalcinosis is a chronic articular disease characterized by acute intermittent attacks of arthritis, presence of calcium pyrophosphate dihydrate crystal in synovial fluid, cartilage and periarticular soft tissue and by x rays calcium deposition in articular cartilage. A family originating from Alsace, with an autosomal dominant transmission has been studied. As in English and Argentinean families, a linkage to the short arm of chromosome 5p has been found. These results suggest that a defective gene at this location may be related to the chondrocalcinosis in these families.
Netter
P
P
L'UMR 7561 CNRS-UHP Physiopathologie et Pharmacologie Articulaires, Faculté de Médecine, BP 184, 54505 Vandoeuvre-les-Nancy.
Loeuille
D
D
Jouzeau
J Y
JY
Gillet
P
P
Peterschmitt
J
J
Pourel
J
J
Gaucher
A
A
D000328:Adult; D002805:Chondrocalcinosis / Q000175:diagnosis / Q000235:genetics* / Q000503:physiopathology; D005602:France; D006801:Humans