[Antibody to human herpesvirus type-8 in the general populations of Xinjiang Autonomous Region(A.R.)].
OBJECTIVE
Kaposi 's sarcoma (KS) does not rarely occur in Xinjiang A. R. Much of the evidence show that human herpes virus-8 (HHV-8) is associated with KS, and the different incidence of classic KS among different countries reflects the different prevalence in general populations. The aim of this study was to know whether the prevalence of HHV-8 is higher in general populations of Xinjiang than the other places of the country.


METHODS
We used BCBL-1 cell line as antigen and collected 1071 serum sample of different nationalities (Uighur, Khalkhas, Kazak and Han nationality) from south and north regions of Xinjiang A. R. for detection of HHV-8 IgG antibody by IFA.


RESULTS
The results showed that HHV-8 IgG antibody positive rate in Khalkhas was 48% (96/200), Uighur 30.4%(62/204), Kazak 12.5% (25/200) and Han 16.9% (79/467). While sera were diluted in 1:20, the positive rate in Khalkhas still was as high as 30.5% (61/200). In addition, the positive rate of HHV-8 IgG antibody in minorities in the same native area all were higher than Han except Kazak nationality.


CONCLUSIONS
These data illustrated that the prevalence of HHV-8 IgG antibody in general populations of different nationality was different, Khalkhas and Uighur were higher than Kazak and Han. Most of the KS cases were reported from Uighur nationality, but no case was reported from Khalkhas thought a highest HHV-8 IgG antibody detection rate (48%) there was demonstrated. The reason for it would be further studied.
Du
W
W
Institute of Pediatrics, Xinjiang Uighur Autonomous Region, Urumqi 830001, China.
Chen
G
G
Sun
H
H
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood*; D002681:China / Q000453:epidemiology; D019288:Herpesvirus 8, Human / Q000276:immunology*; D006801:Humans; D012514:Sarcoma, Kaposi / Q000453:epidemiology / Q000821:virology*; D016036:Seroepidemiologic Studies
D000914:Antibodies, Viral