Glucose-6-phosphate dehydrogenase deficiency promotes endothelial oxidant stress and decreases endothelial nitric oxide bioavailability.
Leopold
J A
JA
Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Massachusetts 02118, USA. jane.leopold@bmc.org
Cap
A
A
Scribner
A W
AW
Stanton
R C
RC
Loscalzo
J
J
D000818:Animals; D001011:Aorta; D002417:Cattle; D006152:Cyclic GMP / Q000032:analysis; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000378:metabolism*; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005954:Glucosephosphate Dehydrogenase / Q000037:antagonists & inhibitors* / Q000235:genetics / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000494:pharmacology; D009249:NADP / Q000378:metabolism; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism; D052250:Nitric Oxide Synthase Type III; D016376:Oligonucleotides, Antisense / Q000235:genetics / Q000494:pharmacology; D018384:Oxidative Stress; D011621:Pteridines / Q000494:pharmacology; D011622:Pterins; D017382:Reactive Oxygen Species / Q000378:metabolism; D014162:Transfection
D004791:Enzyme Inhibitors; D016376:Oligonucleotides, Antisense; D011621:Pteridines; D011622:Pterins; D017382:Reactive Oxygen Species; D009569:Nitric Oxide; D003687:Dehydroepiandrosterone; D009249:NADP; D006861:Hydrogen Peroxide; C016727:sepiapterin; D005954:Glucosephosphate Dehydrogenase; D019001:Nitric Oxide Synthase; D052250:Nitric Oxide Synthase Type III; D006152:Cyclic GMP