title: Isoquinoline alkaloids from Mahonia aquifolium stem bark are active against Malassezia spp.
abstract: Bioassay directed fractionation of crude extract from Mahonia aquifolium led to the isolation of fraction A (bisbenzylisoquinoline alkaloid complex, BBI) and a fraction of protoberberine alkaloids, where the major compounds berberine and jatrorrhizine were isolated as their iodides. The antifungal activity of the crude extract, two protoberberine alkaloids and BBI from M. aquifolium stem bark were evaluated against six strains of Malassezia spp. The compounds tested were generally found to possess only weak to moderate antifungal properties: the MICs for individual strains were in the range < or = 50-> or = 1000 mg/L.
authors.affiliation: Mycological Laboratory, Department of Dermatovenerology, Slovak Postgraduate Academy of Medicine, Bratislava.
authors.forename: A
authors.initials: A
authors.lastname: Volleková
authors.forename: D
authors.initials: D
authors.lastname: Kostálová
authors.forename: R
authors.initials: R
authors.lastname: Sochorová
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D003881:Dermatomycoses / Q000382:microbiology; D007546:Isoquinolines / Q000302:isolation & purification* / Q000494:pharmacology; D028143:Mahonia / Q000737:chemistry*; D008290:Malassezia / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010915:Pityriasis / Q000382:microbiology; D024301:Plant Bark / Q000737:chemistry
chemical_list: D000470:Alkaloids; D000935:Antifungal Agents; D007546:Isoquinolines