title: Water sorption-desorption test and moisture accumulation test for functional assessment of atopic skin in children.
abstract: Sorption-desorption and moisture accumulation tests are simple and quick methods for the in vivo functional analysis of stratum corneum hydration kinetics. The aim of this study was to evaluate the hydration dynamics of the uninvolved and affected skin of children with atopic dermatitis and to compare them with the skin of healthy children. The study investigated 45 children. The dynamic tests were performed using the corneometer CM820. Numerical parameters were calculated. With the sorption-desorption test, eczematous skin showed lower water accumulation during the sorption phase, whereas water was released more slowly during the desorption phase. With the moisture accumulation test, increases in water accumulation velocity and in water accumulation were observed in atopic children. Dynamic tests showed that the stratum corneum of unaffected atopic skin was less hydrated but more easily hydratable than normal skin. Conversely, despite a lower absorption capability, eczematous skin showed a greater avidity to retain water. New functional parameters (water-sorption capacity and accumulated water decay) are proposed to describe more precisely the hydration kinetics of eczematous skin.
authors.affiliation: Department of Dermatology, University of Modena and Reggio Emilia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Pellacani
authors.forename: S
authors.initials: S
authors.lastname: Seidenari
mesh_terms: D001834:Body Water / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption / Q000502:physiology; D014867:Water / Q000378:metabolism*
chemical_list: D014867:Water