title: To bind or not to bind.
abstract: Gene expression is regulated by transcription factors binding selectively to particular portions of the genome. To what extent are these protein-DNA interactions influenced by the intrinsic sequence-specific recognition properties at each protein, and to what extent are they affected by other factors, such as chromatin structure or cooperative interactions with other proteins. Genome-wide surveys of DNA binding by transcription factors in vivo are beginning to provide some answers.
authors.forename: M D
authors.initials: MD
authors.lastname: Biggin
mesh_terms: D000818:Animals; D002843:Chromatin / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D004330:Drosophila / Q000235:genetics; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D011485:Protein Binding / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D012441:Saccharomyces cerevisiae / Q000235:genetics; D013379:Substrate Specificity / Q000235:genetics; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic / Q000502:physiology; D014466:Ultraviolet Rays
chemical_list: D002843:Chromatin; D003432:Cross-Linking Reagents; D014157:Transcription Factors; D004247:DNA