Phosphorylation of filamin (ABP-280) regulates the binding to the lipid membrane, integrin, and actin.
Actin-binding protein (ABP-280; filamin) is a phosphoprotein present in the periphery of the cytoplasm, where it can cross-link actin filaments, associate with lipid membranes, and bind to membrane surface receptors. Given its function and localization in the cell, the hypothesis that it serves as a substrate for p56lck, a lymphocyte-specific member of the src family of protein tyrosine kinases associated with cell surface glycoproteins is considered. The results suggest conformationally-induced regulation of filamin (ABP-280).
Goldmann
W H
WH
Department of Pathology, Children's Hospital, Harvard Medical School, Boston, MA 02115, USA. wgoldmann@partners.org
D000199:Actins / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism*; D003285:Contractile Proteins / Q000378:metabolism*; D064448:Filamins; D016023:Integrins / Q000378:metabolism*; D008051:Lipid Bilayers / Q000378:metabolism; D008840:Microfilament Proteins / Q000378:metabolism*; D008954:Models, Biological; D010766:Phosphorylation; D011485:Protein Binding
D000199:Actins; D003285:Contractile Proteins; D064448:Filamins; D016023:Integrins; D008051:Lipid Bilayers; D008840:Microfilament Proteins