title: Adenoid cystic carcinoma of Bartholin's gland: a case report.
abstract: OBJECTIVE
  A case of adenoid cystic carcinoma (ACC) of the Bartholin's gland in a 34-year-old woman with unusual presentation and early recurrence is reported.
  
  
  METHODS
  Clinical and histologie features were recorded. Immunohistochemical stains and cell-cycle analysis by flow cytometry technique on paraffin-embedded tumor tissue were performed.
  
  
  RESULTS
  The tumor presented as a painful nodule in the episiotomy scar three months after delivery. Initial treatment included only wide local excision. Six months later local recurrence occurred despite clear surgical margins. Histologically a predominant "classic" cribriform growth pattern was identified. Immunoreactivity in tumor cells supported dual epithelial-myoepithelial differentiation. Estrogen and progesterone receptors were negative. The DNA histogram revealed a diploid stemline and a low S-phase fraction.
  
  
  CONCLUSIONS
  ACC of the Bartholin's gland is a rare malignant tumor with great propensity for local recurrence. The optimal therapeutic approach has not been established due to the lack of well-defined prognostic parameters.
authors.affiliation: Department of Pathology, University of Rijeka, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Krasević
authors.forename: H
authors.initials: H
authors.lastname: Haller
authors.forename: Z
authors.initials: Z
authors.lastname: Iternicka
authors.forename: I
authors.initials: I
authors.lastname: Valstelić
authors.forename: N
authors.initials: N
authors.lastname: Matejcić
mesh_terms: D000328:Adult; D001472:Bartholin's Glands / Q000473:pathology / Q000601:surgery; D003528:Carcinoma, Adenoid Cystic / Q000473:pathology / Q000601:surgery; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D009364:Neoplasm Recurrence, Local; D014846:Vulvar Neoplasms / Q000473:pathology / Q000601:surgery