Evolving concepts in epithelial magnesium transport.
Magnesium is an important, predominantly intracellular cation that is required for a wide variety of cellular processes. The mammalian kidney plays a key role in whole-body magnesium homeostasis, but the molecular and cellular mechanisms that underlie renal epithelial magnesium reabsorption are poorly understood. Traditional physiologic approaches have been severely hampered by the lack of a useful radioisotope of magnesium that can be used for tracer flux studies. The present review discusses physiologic insights gained from recent reverse-genetic studies that have identified a plethora of genes involved in inherited renal magnesium wasting syndromes.
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D000818:Animals; D001692:Biological Transport; D004848:Epithelium / Q000378:metabolism; D005799:Genes, Dominant; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008138:Loop of Henle / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism*; D008275:Magnesium Deficiency / Q000235:genetics; D009398:Nephrology / Q000639:trends*; D009399:Nephrons / Q000378:metabolism
D008274:Magnesium