Material-specific memory changes after anterior temporal lobectomy as predicted by the intracarotid amobarbital test.
OBJECTIVE
The intracarotid amobarbital test (IAT) has been shown to predict verbal memory changes after anterior temporal lobectomy (ATL). Seeking to extend these findings, we examined two questions: (a) What is the relationship between material-specific aspects of IAT memory and material-specific memory changes after ATL? and (b) Which IAT memory score(s) optimally predict memory changes after surgery, the memory score after injection ipsilateral to the seizure focus, the memory score after injection contralateral to the seizure focus, or the IAT asymmetry score, comprising the ipsilateral minus contralateral injection scores?


METHODS
Seventy left hemisphere language-dominant patients undergoing ATL for treatment of medically refractory seizures were administered a verbal and visuospatial recognition memory test before surgery and 3 weeks after surgery. IAT memory recognition scores for words and designs were used to predict verbal and visuospatial memory changes after surgery.


RESULTS
After surgery, left ATL patients declined in verbal memory, whereas right ATL patients declined in visuospatial memory. IAT total recognition memory scores (collapsed across all types of materials) and IAT word memory scores were associated with postoperative verbal memory decline. This relationship was significant for the IAT ipsilateral injection memory scores and the IAT hemispheric asymmetry scores. IAT memory performances were not related to visuospatial memory changes.


CONCLUSIONS
Results indicate IAT memory measures to be related to postoperative verbal, but not visuospatial, memory change. A specific relationship was found between postoperative verbal memory change and IAT verbal memory after injection ipsilateral to the seizure focus, when relying primarily on the contralateral hemisphere. This finding is consistent with the functional reserve model of memory change in ATL.
Chiaravalloti
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Department of Neurology, University of Pennsylvania, Philadelphia, Pennsylvania, USA. nchiaravalloti@kmrrec.org
Glosser
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D000328:Adult; D000654:Amobarbital / Q000494:pharmacology; D002343:Carotid Artery, Internal; D004828:Epilepsies, Partial / Q000175:diagnosis / Q000601:surgery*; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000601:surgery; D007839:Functional Laterality / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007261:Infusions, Intra-Arterial; D008568:Memory / Q000187:drug effects / Q000502:physiology; D008569:Memory Disorders / Q000175:diagnosis*; D009483:Neuropsychological Tests / Q000706:statistics & numerical data; D011183:Postoperative Complications / Q000175:diagnosis*; D012044:Regression Analysis; D013702:Temporal Lobe / Q000502:physiology / Q000601:surgery*; D014706:Verbal Learning / Q000187:drug effects / Q000502:physiology; D014888:Wechsler Scales / Q000706:statistics & numerical data
D000654:Amobarbital