Coordination of Ca2+ signalling by NAADP.
Nicotinic acid adenine dinucleotide phosphate (NAADP) mobilizes intracellular Ca2+ stores in several cell types. Ample evidence suggests that NAADP activates intracellular Ca2+ channels distinct from those that are sensitive to inositol trisphosphate and ryanodine/cyclic ADP-ribose. Recent studies in intact cells have demonstrated functional coupling ('channel chatter') between Ca2+ release pathways mediated by NAADP, inositol trisphosphate and cyclic ADP-ribose. Thus, NAADP is probably an important determinant in shaping cytosolic Ca2+ signals.
Patel
S
S
Dept of Pharmacology, University of Oxford, Mansfield Road, OX1 3QT, Oxford, UK. sandip.patel@pharmacology.ox.ac.uk
Churchill
G C
GC
Galione
A
A
D020013:Calcium Signaling / Q000502:physiology*; D009249:NADP / Q000031:analogs & derivatives / Q000502:physiology*
D009249:NADP; C024376:NAADP