title: Deep venous thrombosis of the extremity diagnosed by color Doppler ultrasonography after isolated limb perfusion.
abstract: OBJECTIVE
  Isolated limb perfusion (ILP) is used to treat locally advanced sarcoma and melanoma of the extremities. ILP is associated with a 1.7% to 10% incidence of deep venous thrombosis (DVT). The aim of the study was to examine the effect of ILP on the peripheral venous system and to evaluate the diagnostic accuracy of color Doppler ultrasonography (US).
  
  
  METHODS
  A total of 26 patients with locally advanced sarcoma or melanoma of the extremities received a total of 38 ILP. The patients were evaluated preoperatively and postoperatively by color Doppler US as a noninvasive venous measurement. We used a color Doppler US system (SSA-270A, Toshiba) with a 7.5-MHz linear transducer for gray-scale imaging and a 5-MHz vascular transducer for color Doppler imaging.
  
  
  RESULTS
  Seventeen patients underwent single ILP while the others were treated with multiple ILPs. Color Doppler US showed a reflux flow in three (7.9%) patients and DVT occurred subsequently in these patients.
  
  
  CONCLUSIONS
  Color Doppler US is a noninvasive and clinically useful diagnostic technique in the diagnosis of extremity DVT. We recommend anticoagulant therapy in patients with reflux on ultrasonographic examination.
authors.affiliation: Department of Surgical Oncology, Ankara University Medical School, Turkey. ayeroglu_2000@yahoo.com
authors.forename: A
authors.initials: A
authors.lastname: Eroğlu
authors.forename: H
authors.initials: H
authors.lastname: Ozcan
authors.forename: Y
authors.initials: Y
authors.lastname: Eryavuz
authors.forename: H
authors.initials: H
authors.lastname: Kocağlu
authors.forename: S
authors.initials: S
authors.lastname: Demirci
authors.forename: S K
authors.initials: SK
authors.lastname: Aytac
mesh_terms: D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D008875:Middle Aged; D011237:Predictive Value of Tests; D012509:Sarcoma / Q000188:drug therapy; D012878:Skin Neoplasms / Q000188:drug therapy; D018615:Ultrasonography, Doppler, Color; D020246:Venous Thrombosis / Q000000981:diagnostic imaging* / Q000209:etiology*
chemical_list: D000970:Antineoplastic Agents