title: [Effect of angiotensin II on c-fos expression and protein synthesis in cultured rat myocardial cells].
abstract: The present study was to investigate the effects of angiotensin II on c-fos mRNA expression and protein synthesis in cultured neonatal rat myocardial cells. The results showed that angiotensin II induced c-fos mRNA expression, increased protein content in a dose-dependent manner and stimulated 3H-leucine incorporation rate. All these effects were blocked by angiotensin II receptor antagonist saralasin. The angiotensin II-induced expression of c-fos gene was also blocked by Ca2+ channel antagonist nicardipine.
authors.affiliation: Department of Cardiology, Shanghai Sixth People's Hospital, Shanghai 200233.
authors.forename: S J
authors.initials: SJ
authors.lastname: Tan
authors.forename: J Y
authors.initials: JY
authors.lastname: Pan
authors.forename: C Y
authors.initials: CY
authors.lastname: Zhan
authors.forename: X N
authors.initials: XN
authors.lastname: Zhu
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D015870:Gene Expression; D016762:Genes, fos; D009206:Myocardium / Q000166:cytology / Q000378:metabolism*; D014176:Protein Biosynthesis; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D016760:Proto-Oncogene Proteins c-fos; D012333:RNA, Messenger; D000804:Angiotensin II