[The association of radiation-induced apoptosis with radiosensitivity of cervical carcinoma].
OBJECTIVE
To study the relationship between apoptosis, radiation-induced apoptosis and radiosensitivity of cervical carcinoma and find new markers for predicting radiosensitivity.


METHODS
TdT-mediated bio-dUTP nick end labeling (TUNEL) method was used to check apoptosis cells. The association of radiation-induced apoptosis with tumor volume shrinkage, radiation damage grade and local control rate was analysed.


RESULTS
There was no relationship between apoptosis before radiation and tumor volume shrinkage(P > 0.05); Radiation-induced apoptosis had a significant association with tumor volume shrinkage (P < 0.01); In patients with radiation-induced apoptosis 10 or more, the grade of radiation damage IIb-III accounted for 76% (13/17), while for less than 10, it was 39% (5/13, P < 0.05); After 6 months of radiotherapy, local control rate was 88% (15/17) in the former, 69% (9/13) in the latter, respectively (P > 0.05).


CONCLUSIONS
Radiation-induced apoptosis has some reference value for predicting radiosensitivity of cervical carcinoma.
Zhang
M
M
Cancer Hospital Affiliated of Shanghai Medical University, Shanghai 200032.
Cai
S
S
Shi
D
D
D017209:Apoptosis / Q000528:radiation effects*; D001706:Biopsy; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011836:Radiation Tolerance; D011867:Radioisotope Teletherapy; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000532:radiotherapy*
D003037:Cobalt Radioisotopes