New insights into insulin resistance pathophysiology: how it affects glucose and lipid metabolism.
Insulin resistance is a metabolic state encountered in many physiological and physiopathological conditions. Its pivotal effect on glucose and lipid metabolism is increasingly recognised. Over the last few years, numerous molecular/intracellular pathways affected by this condition have been elucidated. The author reviews some recent findings underlying several major metabolic abnormalities. An overview of current and future therapeutics is also provided.
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Centre Hospitalier Jolimont-Lobbes, Rue Ferrer, 159, B-7100 Haine-St-Paul, Belgium. vcol@wanadoo.be
D000818:Animals; D005544:Forecasting; D015870:Gene Expression / Q000502:physiology; D005947:Glucose / Q000235:genetics / Q000378:metabolism; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006949:Hyperlipidemias / Q000503:physiopathology; D007333:Insulin Resistance / Q000502:physiology*; D050356:Lipid Metabolism; D008055:Lipids / Q000235:genetics
D008055:Lipids; D005947:Glucose