Successful treatment of cervical and simultaneous cervico-isthmic pregnancy with methotrexate.
OBJECTIVE
To describe the monitoring of a case of cervical and simultaneous cervico-isthmic pregnancy.


METHODS
University of Bari (Italy), Department of Obstetrics and Gynecology.


METHODS
A 30-year-old white woman, nulliparous, at 8 weeks of amenorrhoea.


METHODS
Methotrexate and folinic acid administered systemically.


METHODS
Treatment success was defined as elimination of the cervical and cervico-isthmic pregnancy, with non-invasive treatment and preservation of the uterus and normal ovarian activity restored.


RESULTS
Methotrexate and folinic acid were administered, elimination of a twin pregnancy with declining serum beta-hCG levels and with ultrasound was observed. The patient had only occasional dark vaginal bleeding and temporary movement of the transaminase.


CONCLUSIONS
This case report shows that methotrexate is a valid, conservative and non-invasive treatment for a patient affected by cervical pregnancy who wishes to keep fertility.
Melilli
G A
GA
Department of Obstetrics and Gynecology, University of Bari, Italy.
Cormio
G
G
Putignano
G
G
Loverro
G
G
Selvaggi
L
L
D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*
D000020:Abortifacient Agents, Nonsteroidal; D018997:Chorionic Gonadotropin, beta Subunit, Human; D002955:Leucovorin; D008727:Methotrexate