title: Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor.
abstract: The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI.
authors.affiliation: Lomonosov Moscow State University, 119899, Moscow, Russia. gladysheva@enzyme.chem.msu.ru
authors.forename: I P
authors.initials: IP
authors.lastname: Gladysheva
authors.forename: O V
authors.initials: OV
authors.lastname: Polekhina
authors.forename: T A
authors.initials: TA
authors.lastname: Karmakova
authors.forename: E R
authors.initials: ER
authors.lastname: Nemtsova
authors.forename: R I
authors.initials: RI
authors.lastname: Yakubovskaya
authors.forename: W C
authors.initials: WC
authors.lastname: Shen
authors.forename: A R
authors.initials: AR
authors.lastname: Kennedy
authors.forename: N I
authors.initials: NI
authors.lastname: Larionova
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology*; D018938:Caco-2 Cells; D003911:Dextrans; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004852:Epoxy Compounds; D005027:Ethylene Oxide; D005455:Fluorescent Antibody Technique; D006801:Humans; D018796:Immunoconjugates / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology*; D007150:Immunohistochemistry; D051379:Mice; D011108:Polymers; D014018:Tissue Distribution; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D003911:Dextrans; D004337:Drug Carriers; D004852:Epoxy Compounds; D018796:Immunoconjugates; D011108:Polymers; D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D005027:Ethylene Oxide; C009068:propylene oxide