The influence of donor brain death on short and long-term outcome of solid organ allografts.
Long-term survival rates of solid organ allografts have improved relatively little during the transplant experience despite more effective immunosuppression, better organ preservation techniques and advances in perioperative management. Because grafts of potentially diminished quality are increasingly accepted to reduce the severe shortage of organs, it has become apparent that a variety of donor-associated risk factors may influence adversely their short and long-term outcome. Recent interest has focused particularly on systemic changes occurring after donor brain death (BD). Numbers of experimental and clinical studies have elucidated the complexities of the hemodynamic, metabolic, neurohormonal, and other physiological alterations following this devastating central injury. This article will address the potential derangements in peripheral organs which may influence their behavior after transplantation.
Gasser
M
M
Surgical Research Laboratory, Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
Waaga
A M
AM
Laskowski
I A
IA
Tilney
N L
NL
D001926:Brain Death / Q000503:physiopathology*; D006085:Graft Survival; D006321:Heart / Q000503:physiopathology; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008099:Liver / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology; D009926:Organ Preservation; D016377:Organ Transplantation; D015427:Reperfusion Injury / Q000503:physiopathology; D012307:Risk Factors; D013997:Time Factors; D014019:Tissue Donors