title: Prenatal morphine exposure induces age- and sex-dependent changes in seizure susceptibility.
abstract: 1. Prenatal exposure to morphine induces long-term alterations in seizure susceptibility, which are age-, sex-, and seizure model-specific. 2. Adult male and female rats exposed prenatally to morphine show decreased susceptibility to GABA-regulated seizures. 3. Prenatally morphine-exposed, adult male rats are more sensitive to excitatory amino acid receptor-mediated seizures than control males, control females, or morphine-exposed females.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx 10461, NY, USA. vathy@aecom.yu.edu
authors.forename: I
authors.initials: I
authors.lastname: Vathy
mesh_terms: D000367:Age Factors; D000375:Aging / Q000187:drug effects; D000818:Animals; D004198:Disease Susceptibility; D005260:Female; D006801:Humans; D008297:Male; D009020:Morphine / Q000009:adverse effects*; D009294:Narcotics / Q000009:adverse effects*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism; D012727:Sex Characteristics; D012737:Sex Factors
chemical_list: D009294:Narcotics; D009020:Morphine