title: Modulatory effect of quercetin on azathioprine induced membrane changes in the mouse spleen.
abstract: Modulatory effect of quercetin on azathioprine induced toxic changes was studied in spleen of experimental animals. Azathioprine treatment caused an increase in serum albumin/globin ratio and a decrease in total protein in spleen tissue. An increase in a membrane bound ATPases was also noted. Supplementation of quercetin with azathioprine increased the protein content and lowered the activities of membrane ATPase in spleen. There was a decrease in serum albumin globulin ratio. It was concluded that quercetin modulated the protein and membrane bound ATPase activities and protected the spleen from azathioprine induced membrane damage.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India.
authors.forename: S
authors.initials: S
authors.lastname: Chitra
authors.forename: S
authors.initials: S
authors.lastname: Devipriya
authors.forename: C S
authors.initials: CS
authors.lastname: Shyamala Devi
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001379:Azathioprine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005916:Globulins / Q000378:metabolism; D008297:Male; D051379:Mice; D011794:Quercetin / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
chemical_list: D005916:Globulins; D012709:Serum Albumin; D011794:Quercetin; D000251:Adenosine Triphosphatases; D001379:Azathioprine