title: Na+/Ca2+ exchange current in myocytes isolated from rat hypertrophied heart.
abstract: Effects of myocardial hypertrophy on the Na+/Ca2+ exchange current in isolated rat cardiac myocytes were investigated, using whole cell patch techniques. Goldblatt 2-kidney, one-clip technique was used to induce cardiomyocyte hypertrophy. The results demonstrated that the Ni(2+)-sensitive Na+/Ca2+ exchange current density was larger in hypertrophied cells than that in normal cells. At a holding potential of  mV, the outward current densities were 1.53 +/- 0.31 pA/pF in normal cells and 2.62 +/- 0.53 pA/pF in hypertrophied cells (P < 0.01). At a holding potential of -100 mV, the inward current densities were 0.42 +/- 0.14 pA/pF in normal cells and 1.12 +/- 0.33 pA/pF in hypertrophied cells (P < 0.001). The results suggest that during myocardial hypertrophy the Na+/Ca2+ exchange current is significantly increased.
authors.affiliation: Department of Physiology, Shanxi Medical University, Taiyuan 030001.
authors.forename: J Y
authors.initials: JY
authors.lastname: Lu
authors.forename: D M
authors.initials: DM
authors.lastname: Wu
authors.forename: B W
authors.initials: BW
authors.lastname: Wu
authors.forename: W X
authors.initials: WX
authors.lastname: Chai
authors.forename: C S
authors.initials: CS
authors.lastname: Kang
authors.forename: T L
authors.initials: TL
authors.lastname: Li
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006332:Cardiomegaly / Q000378:metabolism / Q000503:physiopathology*; D002469:Cell Separation; D004594:Electrophysiology; D006978:Hypertension, Renovascular / Q000150:complications / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000378:metabolism* / Q000473:pathology; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D019831:Sodium-Calcium Exchanger / Q000502:physiology*
chemical_list: D019831:Sodium-Calcium Exchanger; D002118:Calcium