title: [Plasma electrolytes in multiple myeloma].
abstract: The plasma cell myeloma (multiple myeloma, myelomatosis) is a progressive disease, characterized by bone marrow plasmacytomas and the presence of monoclonal antibodies (IgG, IgA, IgD, IgE), or free kappa or lambda immunoglobulin side chains. The monoclonal antibodies or Bence-Jones protein may precipitate in the tubuli and impair kidney function. In addition, the plasma protein concentration may increase at the expense of plasma water level causing unrealistically low electrolyte levels. Since the isoelectric points of immunoglobulins are higher than those of most other plasma proteins, the net charge of plasma proteins may change causing new electrolyte balance. In addition, some monoclonal antibodies are more hydrated than others, and their high concentration may cause not only increased plasma viscosity but further electrolyte imbalance. In the present work the relationship between plasma protein and electrolyte levels is studied in samples of 100 multiple myeloma patients.
authors.affiliation: Pécsi Tudományegyetem, Altalános Orvostudományi Kar, Klinikai Kémiai Intézet.
authors.forename: A
authors.initials: A
authors.lastname: Miseta
authors.forename: M
authors.initials: M
authors.lastname: Kellermayer
authors.forename: F
authors.initials: F
authors.lastname: Liszt
authors.forename: A
authors.initials: A
authors.lastname: Ludány
authors.forename: T
authors.initials: T
authors.lastname: Magyarlaki
authors.forename: K
authors.initials: K
authors.lastname: Sipos
authors.forename: G
authors.initials: G
authors.lastname: Berkó
authors.forename: M
authors.initials: M
authors.lastname: Tókés-Fúzesi
mesh_terms: D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D006801:Humans; D007136:Immunoglobulins / Q000097:blood; D009101:Multiple Myeloma / Q000097:blood*; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D014883:Water-Electrolyte Imbalance / Q000097:blood
chemical_list: D001798:Blood Proteins; D004573:Electrolytes; D007136:Immunoglobulins; D012964:Sodium; D011188:Potassium; D002118:Calcium