Hu 210: a potent tool for investigations of the cannabinoid system.
The synthetic compound HU 210 displays a multiplicity of biochemical, pharmacological, and behavioral effects, most of which have been demonstrated to be dependent on a selective agonistic activity at CB(1) and CB(2) cannabinoid receptors and to involve the main neurotransmitter systems. Results obtained in various studies suggest a potential clinical application of this highly potent drug (e.g., as antipyretic, antiinflammatory, analgesic, antiemetic, and antipsychotic agent) as well as its usefulness in research aimed to develop a better understanding of the involvement of the endogenous cannabinoid system in a number of physiopathological functions.
Ottani
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Department of Biomedical Sciences, Division of Pharmacology, University of Modena and Reggio Emilia, via G. Campi 287, 41100 Modena, Italy.
Giuliani
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D000698:Analgesia; D000818:Animals; D002186:Cannabinoids / Q000276:immunology / Q000494:pharmacology; D002319:Cardiovascular System / Q000187:drug effects / Q000378:metabolism; D013759:Dronabinol / Q000031:analogs & derivatives* / Q000276:immunology / Q000494:pharmacology; D004644:Emotions / Q000187:drug effects; D006801:Humans; D008967:Molecular Biology; D009043:Motor Activity / Q000187:drug effects*
D002186:Cannabinoids; D013759:Dronabinol; C062018:HU 211