[Protective action of corynoline, acetylcorynoline and protopine against experimental liver injury in mice].
Oral administration of two doses of corynoline, acetylcorynoline or protopine at 50 and 100 mg.kg-1 in an interval of 8 to 24 h before i.p. injection of CCl4, acetaminophen or thioacetamide significantly impeded the elevation of serum transaminase (SGPT) and liver damage in mice. The three compounds were found to inhibit CCl4-induced microsomal lipid peroxidation and CCl4 conversing to carbon monoxide in liver microsomes in vitro. Of these compounds, acetylcorynoline was shown to be more potent than corynoline and protopine. In addition, all the three compounds exhibited biphasic effects on the hepatic cytochrome P450, i.e. inhibition followed by induction, in mice.
Wei
H L
HL
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
Liu
G T
GT
D000082:Acetaminophen; D000410:Alanine Transaminase / Q000097:blood; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D002252:Carbon Tetrachloride Poisoning; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology / Q000473:pathology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D013853:Thioacetamide
D000470:Alkaloids; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D013853:Thioacetamide; D000082:Acetaminophen; D003577:Cytochrome P-450 Enzyme System; D000410:Alanine Transaminase; C009093:protopine