Burkholderia cepacia complex: a contraindication to lung transplantation in cystic fibrosis?
Previous studies have indicated that pulmonary infection with Burkholderia cepacia is associated with poor clinical outcome after lung transplantation in cystic fibrosis (CF). Many treatment centers consider B. cepacia infection an absolute contraindication to lung transplantation. However, the B. cepacia complex actually consists of several closely related bacterial species. Although each of these has been isolated from CF sputum culture, certain species are much more frequently recovered than others, and it is not yet clear whether all species have the same potential for virulence in CF. Additional study is needed to better define the relative risks associated with each species of the B. cepacia complex.
LiPuma
J J
JJ
Department of Pediatrics and Communicable Diseases, University of Michigan Medical School, Ann Arbor, Michigan 48109-0646, USA. jlipuma@umich.edu
D019121:Burkholderia Infections / Q000150:complications* / Q000453:epidemiology; D016956:Burkholderia cepacia / Q000302:isolation & purification / Q000472:pathogenicity*; D000075202:Contraindications; D003550:Cystic Fibrosis / Q000150:complications* / Q000382:microbiology; D006801:Humans; D016040:Lung Transplantation; D012307:Risk Factors; D016896:Treatment Outcome; D014774:Virulence