Bifurcation analysis of continuous biochemical reactor models.
The validity of a biochemical reactor model often is evaluated by comparing transient responses to experimental data. Dynamic simulation can be a rather inefficient and ineffective tool for analyzing bioreactor models that exhibit complex nonlinear behavior. Bifurcation analysis is a powerful tool for obtaining a more efficient and complete characterization of the model behavior. To illustrate the power of bifurcation analysis, the steady-state and transient behavior of three continuous bioreactor models consisting of a small number of ordinary differential equations are investigated. Several important features, as well as potential limitations, that are difficult to ascertain via dynamic simulation are disclosed through the bifurcation analysis. The results motivate the use of dynamic simulation and bifurcation analysis as complementary tools for analyzing the nonlinear behavior of bioreactor models.
Zhang
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Y
Department of Chemical Engineering, Louisiana State University, Baton Rouge, Louisiana 70803-7303, USA.
Henson
M A
MA
D000818:Animals; D019149:Bioreactors; D018929:Cell Culture Techniques / Q000295:instrumentation / Q000379:methods*; D006825:Hybridomas; D008962:Models, Theoretical; D015203:Reproducibility of Results; D012441:Saccharomyces cerevisiae; D017355:Zymomonas