Modulatory effect of quercetin on azathioprine induced membrane changes in the mouse spleen.
Modulatory effect of quercetin on azathioprine induced toxic changes was studied in spleen of experimental animals. Azathioprine treatment caused an increase in serum albumin/globin ratio and a decrease in total protein in spleen tissue. An increase in a membrane bound ATPases was also noted. Supplementation of quercetin with azathioprine increased the protein content and lowered the activities of membrane ATPase in spleen. There was a decrease in serum albumin globulin ratio. It was concluded that quercetin modulated the protein and membrane bound ATPase activities and protected the spleen from azathioprine induced membrane damage.
Chitra
S
S
Department of Biochemistry and Molecular Biology, University of Madras, Guindy Campus, Chennai 600 025, India.
Devipriya
S
S
Shyamala Devi
C S
CS
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001379:Azathioprine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D005916:Globulins / Q000378:metabolism; D008297:Male; D051379:Mice; D011794:Quercetin / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism; D013154:Spleen / Q000166:cytology / Q000187:drug effects*
D005916:Globulins; D012709:Serum Albumin; D011794:Quercetin; D000251:Adenosine Triphosphatases; D001379:Azathioprine