CFTR and pseudomonas infections in cystic fibrosis.
Pseudomonas aeruginosa is a significant threat to human health as it is frequently recalcitrant to conventional antibacterial therapy. This ubiquitous gram-negative bacterium is notorious for its nutritional and ecological flexibility and its resistance to both antibiotic treatments and sanitary measures. These properties contribute to its prominence as a leading source of opportunistic nosocomial (hospital acquired) and a less appreciated, but significant cause of community acquired infections. P. aeruginosa remains a considerable problem for patients with burns, neutropenic individuals, and cystic fibrosis patients (CF). In this review, we will address the current issues in P. aeruginosa infections in CF. A major emphasis will be placed on the factors predisposing CF patients to colonization with P. aeruginosa.
Tatterson
L E
LE
Department of Microbiology and Immunology, University of Michigan Medical School, Ann Arbor, MI 48109-0620, USA.
Poschet
J F
JF
Firoved
A
A
Skidmore
J
J
Deretic
V
V
D000818:Animals; D001422:Bacterial Adhesion; D018441:Biofilms / Q000254:growth & development; D003550:Cystic Fibrosis / Q000150:complications* / Q000378:metabolism / Q000382:microbiology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator / Q000235:genetics*; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation / Q000276:immunology; D051379:Mice; D019001:Nitric Oxide Synthase / Q000096:biosynthesis; D052247:Nitric Oxide Synthase Type II; D011552:Pseudomonas Infections / Q000150:complications / Q000378:metabolism / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity* / Q000502:physiology; D020545:Respiratory Mucosa / Q000201:enzymology / Q000382:microbiology; D012141:Respiratory Tract Infections / Q000150:complications / Q000378:metabolism / Q000382:microbiology*; D012799:Sialyltransferases / Q000378:metabolism
C505032:CFTR protein, human; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse; D012799:Sialyltransferases