title: Orthotopic liver transplantation in a young adult (33 years old) using an 84-year-old donor.
abstract: Shortage of liver donors and the increasing number of patients on the waiting list for liver transplantation have led to a widening of the definition of liver donor suitability. Although the age limit for liver donors is controversial, current opinion is towards using liver allografts from donors older than 60 years. However, to date only a few cases that showed a good performance of liver graft by donors older than 60 years have been described. In this case report, orthotopic liver transplantation in a 33-year-old patient who received a graft from an 84-year-old donor is presented. A careful evaluation of the conventional donor-related risk factors (hemodynamics, hepatic function and histologic features) was carried out. Moreover, free radical scavenger glutathione was measured before cold ischemia and at the time of reperfusion in hepatic biopsies. After a 1-year follow-up, the recipient exhibits good general conditions and normal liver function values.
authors.affiliation: Department of Transplantation, S. Martino University Hospital, L.go R. Benzi 10, 16132 Genova, Italy. gsantori@transplant.smartino.ge.it
authors.forename: G
authors.initials: G
authors.lastname: Santori
authors.forename: D
authors.initials: D
authors.lastname: Cottalasso
authors.forename: A
authors.initials: A
authors.lastname: Antonucci
authors.forename: A
authors.initials: A
authors.lastname: Genzone
authors.forename: R
authors.initials: R
authors.lastname: Mondello
authors.forename: R
authors.initials: R
authors.lastname: Valente
authors.forename: N
authors.initials: N
authors.lastname: Morelli
authors.forename: I
authors.initials: I
authors.lastname: Fontana
authors.forename: E
authors.initials: E
authors.lastname: Andorno
authors.forename: U
authors.initials: U
authors.lastname: Valente
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D000075202:Contraindications; D005978:Glutathione / Q000032:analysis; D006801:Humans; D016031:Liver Transplantation / Q000379:methods; D014019:Tissue Donors
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione