title: Does the manic/mixed episode distinction in bipolar disorder patients run true over time?
abstract: OBJECTIVE
  The authors sought to determine whether the manic/mixed episode distinction in patients with bipolar disorder runs true over time.
  
  
  METHODS
  Over an 11-year period, the observed distribution of manic and mixed episodes (N=1,224) for patients with three or more entries in the management information system of a community mental health center (N=241) was compared to the expected distribution determined by averaging 1,000 randomly generated simulations.
  
  
  RESULTS
  Episodes were consistent (all manic or all mixed) in significantly more patients than would be expected by chance.
  
  
  CONCLUSIONS
  These data suggest a pattern of diagnostic stability over time for manic and mixed episodes in patients with bipolar disorder. Careful prospective studies of this issue are needed.
authors.affiliation: Department of Psychiatry, Treatment Research Program, Connecticut Mental Health Center, Yale University School of Medicine, 34 Park St., New Haven, CT 06519, USA. scott.woods@yale.edu
authors.forename: S W
authors.initials: SW
authors.lastname: Woods
authors.forename: R
authors.initials: R
authors.lastname: Money
authors.forename: C B
authors.initials: CB
authors.lastname: Baker
mesh_terms: D001714:Bipolar Disorder / Q000175:diagnosis* / Q000523:psychology; D003155:Community Mental Health Centers; D003198:Computer Simulation; D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008331:Management Information Systems / Q000706:statistics & numerical data; D011336:Probability; D011897:Random Allocation; D012189:Retrospective Studies; D016008:Statistical Distributions