title: Moving Up the Coagulation Cascade: Potential Factor X Inhibition for Percutaneous Coronary Intervention.
abstract: Contrary to recent thinking in platelet biology, which had taken a strong stance on final common pathway concepts, the pharmacologic approach to tempering vascular coagulation has moved upstream to earlier steps in the fundamental process. Because coagulation represents a series of bioamplification sequences, the inhibition of early autocatalytic reactions minimizes the production of downstream substrate. The neutralization of factor X, a pivotal coagulation protease in thrombin generation, represents a particularly attractive target in arterial thrombosis following vessel wall trauma in percutaneous coronary interventions.
authors.affiliation: Cardiovascular Thrombosis Research Center and Anticoagulation Services, University of Massachusetts-Memorial Medical Center, 55 Lake Avenue, North Worcester, MA 01655, USA. beckerr@ummhc.org
authors.forename: Richard C.
authors.initials: RC
authors.lastname: Becker
authors.forename: Frederick A.
authors.initials: FA
authors.lastname: Spencer