title: Relative pathogenicity of Candida tropicalis in rat tongue mucosa.
abstract: The potential of C. tropicalis to colonize and infect rat tongue mucosa was demonstrated. Thirty female Sprague-Dawley rats were infected orally with three different strains of C. tropicalis. The animals were killed one and three weeks following the inoculation and sections of their tongue were stained with hematoxylin-eosin and Grocott stain. Histological changes were observed in the group of animals killed one week after inoculation and infected with C. tropicalis strain isolated from the crural ulcer of a diabetic patient. The most important finding was acute purulent myositis with the formation of abscesses. The myositis was local without signs of spreading to the surrounding tissue. Epithelium-penetrating hyphae observed in the Grocott-stained sections were relatively fewer and more sparsely distributed.
authors.affiliation: Department of Physiology, Faculty of Medicine, Safárik University, 040 66 Kosice, Slovakia.
authors.forename: E
authors.initials: E
authors.lastname: Dorko
authors.forename: E
authors.initials: E
authors.lastname: Pilipcinec
authors.forename: I
authors.initials: I
authors.lastname: Bracoková
authors.forename: A
authors.initials: A
authors.lastname: Jenca
authors.forename: E
authors.initials: E
authors.lastname: Svický
authors.forename: J
authors.initials: J
authors.lastname: Danko
authors.forename: L
authors.initials: L
authors.lastname: Tkáciková
authors.forename: F
authors.initials: F
authors.lastname: Dorko
authors.forename: M
authors.initials: M
authors.lastname: Kocisová
authors.forename: K
authors.initials: K
authors.lastname: Lovásová
mesh_terms: D000038:Abscess / Q000209:etiology / Q000473:pathology; D000818:Animals; D002175:Candida / Q000302:isolation & purification / Q000472:pathogenicity*; D002180:Candidiasis, Oral / Q000209:etiology / Q000473:pathology; D005260:Female; D006801:Humans; D009092:Mucous Membrane / Q000382:microbiology / Q000473:pathology; D009220:Myositis / Q000209:etiology / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014059:Tongue / Q000382:microbiology* / Q000473:pathology; D014060:Tongue Diseases / Q000209:etiology / Q000473:pathology