[Thermodynamic approach to the selection of polyuronide sequestrants for protection of the human body from toxic metal ions. Interactions of polyuronides with lead ions].
Binding isotherms of Pb2+ ions with potassium pectate and potassium alginate with relatively low content of blocks of L-guluronic residues (20%) have been determined. Interactions of Pb2+ ions with polyuronides studied is cooperative. Maximum values of binding constants are an order of magnitude higher than previously determined ones for Ca2+ and Sr2+ ions. Along with ion-coordination ("stoichiometric") interactions, alginate is typified by so-called extra-stoichiometric binding of Pb2+ ions, which presumably proceeds by a coprecipitation mechanism. Limitations of the thermodynamic approach to the selection of sequestrants for human body protection from toxic metal ions are discussed.
Braudo
E E
EE
Danilova
I V
IV
Dianova
V T
VT
Kobak
V V
VV
Plashchina
I G
IG
D000464:Alginates; D002614:Chelating Agents; D006801:Humans; D007854:Lead / Q000378:metabolism / Q000633:toxicity*; D010368:Pectins; D013816:Thermodynamics; D014574:Uronic Acids
D000464:Alginates; D002614:Chelating Agents; D014574:Uronic Acids; C018402:traumacel; D007854:Lead; D010368:Pectins; C003181:polygalacturonic acid