title: Stroke in a young man with fibromuscular dysplasia of the cranial vessels with anticardiolipin antibodies: a case report.
abstract: A case of fibromuscular dysplasia (FMD), presenting with a non-hemorrhagic infarct is reported. Positivity of anticardiolipin antibodies suggested an immune response. A 40-year-old man presented with sudden onset of stroke, preceded by similar ischemic attacks. Computed tomography (CT) of the brain showed a recent non-hemorrhagic infarct in the left middle cerebral artery (MCA) territory and an old right MCA territory infarct. Serum was positive for anticardiolipin antibodies. These above findings were confirmed at autopsy. A portion of the internal carotid artery and the middle cerebral arteries on both sides revealed features of FMD, with thrombosis. This case suggests an immune mechanism for FMD, hitherto unobserved in the cerebral circulation.
authors.affiliation: Department of Neurology, CN Center, Ansari Nagar, New Delhi, India.
authors.forename: M
authors.initials: M
authors.lastname: Tripathi
authors.forename: V
authors.initials: V
authors.lastname: Santosh
authors.forename: D
authors.initials: D
authors.lastname: Nagaraj
authors.forename: R
authors.initials: R
authors.lastname: Christhopher
authors.forename: P S
authors.initials: PS
authors.lastname: Chandra
authors.forename: S K
authors.initials: SK
authors.lastname: Shankar
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000097:blood* / Q000276:immunology*; D000927:Anticonvulsants / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D005352:Fibromuscular Dysplasia / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D006801:Humans; D020244:Infarction, Middle Cerebral Artery / Q000503:physiopathology*; D008297:Male; D020768:Middle Cerebral Artery / Q000503:physiopathology*; D010672:Phenytoin / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy / Q000503:physiopathology; D016896:Treatment Outcome
chemical_list: D017153:Antibodies, Anticardiolipin; D000927:Anticonvulsants; D010672:Phenytoin