title: Long-term effects on the intelligence of children treated for acute lymphoblastic leukemia.
abstract: The purpose of this study was to investigate whether the intelligence quotient (IQ) in children treated for leukemia decreases in the years following whole brain irradiation. Twenty-seven leukemic children were assessed following a mean time lapse between radiotherapy and IQ measurement of 9 years. The IQ test used was the Hamburg Weschsler Intelligence Test for Adults. The IQ results did not differ significantly, p > 0.05, from the IQs of the general population. It was found that age and dose were not predictors of a decrease in IQ. The only predictor was time lapse between irradiation and IQ measurement, which we found to be indicative of an IQ decrease even after 9 years. Time lapse between irradiation is a useful predictor of IQ.
authors.affiliation: Department of Radiation Medicine, Offenbach, Germany. ckolotas@aol.com
authors.forename: C
authors.initials: C
authors.lastname: Kolotas
authors.forename: M
authors.initials: M
authors.lastname: Daniel
authors.forename: L
authors.initials: L
authors.lastname: Demetriou
authors.forename: T
authors.initials: T
authors.lastname: Martin
authors.forename: R
authors.initials: R
authors.lastname: Kurek
authors.forename: C
authors.initials: C
authors.lastname: Tonus
authors.forename: U
authors.initials: U
authors.lastname: Göbel
authors.forename: T
authors.initials: T
authors.lastname: Schnabel
authors.forename: N
authors.initials: N
authors.lastname: Zamboglou
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000517:prevention & control; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D007360:Intelligence; D008727:Methotrexate / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000523:psychology* / Q000532:radiotherapy*; D011879:Radiotherapy Dosage; D012008:Recurrence; D017741:Survivors; D013997:Time Factors; D014888:Wechsler Scales
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate