title: Heart rate variability in chronic heart failure.
abstract: The analysis of heart rate variability (HRV) provides information about autonomic cardiovascular control in healthy subjects. In the past 15 years, several articles have been published regarding HRV and chronic heart failure (CHF). The results of these papers substantially demonstrated that HRV is significantly different in CHF patients compared to controls. Moreover, some variables derived from HRV analysis showed significant independent prognostic capacity. In particular, the reduction of variance (expressed as SDNN) and low-frequency spectral component of HRV (ranging from 0.03 to 0.15 Hz) seem related to an increased mortality in CHF. Nevertheless, these variables are not yet considered in clinical practice. A better understanding of the physiopathological basis of the reported alterations of HRV in CHF patients is required in order to permit its use as a clinical tool for prognosis and tailored therapy in individual CHF patients.
authors.affiliation: Centro Ricerche Cardiovascolari, Università di Milano, Italy. stefanog@fisiopat.sacco.unimi.it
authors.forename: S
authors.initials: S
authors.lastname: Guzzetti
authors.forename: R
authors.initials: R
authors.lastname: Magatelli
authors.forename: E
authors.initials: E
authors.lastname: Borroni
authors.forename: S
authors.initials: S
authors.lastname: Mezzetti
mesh_terms: D002908:Chronic Disease; D006333:Heart Failure / Q000503:physiopathology*; D006339:Heart Rate / Q000502:physiology*; D006801:Humans; D013564:Sympathetic Nervous System / Q000503:physiopathology*