title: Anterior lenticonus: histological evaluation and approach for cataract surgery.
abstract: OBJECTIVE
  To present 2 cases of anterior lenticonus in patients without Alport's syndrome, a surgical technique of cataract extraction in eyes with anterior lenticonus, and histological results of lenticonus specimens obtained intraoperatively.
  
  
  METHODS
  From St. Eriks Eye Clinic, Karolinska Institute, Stockholm, Sweden.
  
  
  METHODS
  Two otherwise healthy patients presented with anterior lenticonus but no history of Alport's or other pathology. Best corrected visual acuity (BCVA) was decreased. Both patients had cataract extraction by phacoemulsification with intraocular lens implantation under topical anesthesia. Two continuous curvilinear capsulorhexes (CCCs) were created. The entire lenticonus was embedded in formaldehyde buffer 4% for histological analysis.
  
  
  RESULTS
  In the first patient, BCVA did not improve postoperatively because of amblyopia. The patient subjectively reported a substantial improvement in visual field clarity. The surgical and postoperative course in the other patient was uneventful. The sections were positive for collagen types IV and VI, and the arrangement of the collagen fibers was highly irregular.
  
  
  CONCLUSIONS
  Anterior lenticonus was detected in patients without Alport's syndrome who were otherwise healthy. A modified 2-step CCC technique can be used to make cataract surgery in such eyes safe and relatively easy.
authors.affiliation: St. Eriks Eye Clinic, Karolinska Institute, Polhemsgatan 52, 11282 Stockholm, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: van Setten
mesh_terms: D000772:Anesthesia, Local; D003094:Collagen / Q000032:analysis; D005124:Eye Abnormalities / Q000473:pathology* / Q000601:surgery*; D005260:Female; D006801:Humans; D019654:Lens Implantation, Intraocular; D007908:Lens, Crystalline / Q000002:abnormalities* / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D018918:Phacoemulsification / Q000379:methods*; D014792:Visual Acuity
chemical_list: D003094:Collagen