title: Dimethyl sulfoxide: recent pharmacological and toxicological research.
abstract: A survey of the literature published in the past 2 decades on the basic pharmacology, therapeutic uses and toxicity of dimethyl sulfoxide (DMSO) is presented. A salient pharmacological action of DMSO is its ability to scavenge oxygen-free radicals implicated in xenobiotic-induced tissue damages when given before, during or several hours after the tissue insult. More trials with DMSO in diseases and conditions caused by oxygen-free radicals are warranted.
authors.affiliation: Department of Veterinary Medicine, King Saud University, Buraydah, Saudi Arabia.
authors.forename: B H
authors.initials: BH
authors.lastname: Ali
mesh_terms: D000818:Animals; D004121:Dimethyl Sulfoxide / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D016166:Free Radical Scavengers / Q000493:pharmacokinetics / Q000627:therapeutic use / Q000633:toxicity; D006801:Humans; D007928:Lethal Dose 50; D051381:Rats
chemical_list: D016166:Free Radical Scavengers; D004121:Dimethyl Sulfoxide