title: Hsp90 as an anti-cancer target.
abstract: Heat shock protein 90 is one of the most abundant cellular proteins. Although its functions are still being characterized, it appears to serve as a chaperone for a growing list of cell signaling proteins, including many tyrosine and serine/threonine kinases, involved in cell proliferation and/or survival. The recent discovery of natural products which are able to inhibit Hsp90 function have allowed for both identification of its client proteins and for a better understanding of its role in their activity. Accumulating data have suggested that targeting Hsp90 in cancer cells may be of clinical benefit. Copyright 1999 Harcourt Publishers Ltd.
authors.affiliation: Department of Cell and Cancer Biology, Medicine Branch, NIH Rockville, MD, USA
authors.forename: Len
authors.initials: L
authors.lastname: Neckers
authors.forename: Edward
authors.initials: E
authors.lastname: Mimnaugh
authors.forename: Theodor W.
authors.initials: TW
authors.lastname: Schulte