title: EPR tooth enamel dosimetry: optimization of the automated spectra deconvolution routine.
abstract: A computer routine was developed for automatic deconvolution of electron paramagnetic resonance spectra of tooth enamel samples for individual radiation dose reconstruction in the low dose region. The deconvolution routine uses the non-linear least square fit of a model simulating a tooth enamel spectrum by superposition of derivative Gaussian functions to obtain the amplitude of the dosimetric radiation induced signal. The parameters of the model and of the routine were optimized on a dose response level using a criterion of the least standard deviation of the derived radiation induced signal amplitude from the regression line vs. the nominal doses for the series of spectra of samples irradiated in known doses in the range 0-500 mGy. It was found that for the series of spectra of the heterogeneous samples (every sample is prepared from different teeth of different persons), it is essential to vary in the least square fit the parameters describing the shape of the native background signal in order to obtain the best accuracy. In the case of the series of spectra of the homogeneous (pooled) samples, almost the same accuracy of the results was obtained using the procedures with varied and fixed background signal parameters. The standard error of the dose reconstruction by the optimized deconvolution procedure was estimated as about 30 mGy for heterogeneous samples and 20 mGy for homogeneous samples.
authors.affiliation: Medical Radiological Research Center, Obninsk, Russia. ivann@mail.ru
authors.forename: A I
authors.initials: AI
authors.lastname: Ivannikov
authors.forename: V G
authors.initials: VG
authors.lastname: Skvortsov
authors.forename: V F
authors.initials: VF
authors.lastname: Stepanenko
authors.forename: D D
authors.initials: DD
authors.lastname: Tikunov
authors.forename: J
authors.initials: J
authors.lastname: Takada
authors.forename: M
authors.initials: M
authors.lastname: Hoshi
mesh_terms: D000465:Algorithms; D001331:Automation; D002138:Calibration; D003037:Cobalt Radioisotopes / Q000032:analysis*; D003198:Computer Simulation; D003743:Dental Enamel / Q000737:chemistry*; D004578:Electron Spin Resonance Spectroscopy / Q000379:methods; D006801:Humans; D008963:Molar / Q000737:chemistry; D011834:Radiation Monitoring / Q000379:methods*; D011874:Radiometry / Q000379:methods; D012044:Regression Analysis; D012984:Software
chemical_list: D003037:Cobalt Radioisotopes