Inhibition by combined therapy with ticlopidine and aspirin of enhanced platelet aggregation during physical exercise in patients with coronary artery disease.
BACKGROUND
Strenuous exercise can be a major trigger for coronary thrombosis and it enhances platelet aggregation.


METHODS
We evaluated the effect of antiplatelet therapy on shear stress-induced platelet aggregation (SIPA), in addition to agonist-induced aggregation, before and immediately after ergometer exercise in patients with stable coronary artery diseases (CAD). Forty-eight patients with stable CAD were randomly distributed into 3 groups: no antiplatelet drug (patient control, n = 16), aspirin (ASA) monotherapy (n = 16), and combined therapy with ticlopidine (TIC) and ASA (n = 16).


RESULTS
There were significant increases in not only adenosine phosphate (ADP)- and collagen-induced platelet aggregation but also in SIPA during exercise by the patient control group. ASA monotherapy did not attenuate the enhanced ADP-induced aggregation nor SIPA. Combined ASA + TIC therapy significantly inhibited SIPA as well as ADP-induced aggregation both before and after exercise. Significant increases in levels of plasma von Willebrand factor (vWF) occurred during exercise, and these antiplatelet therapies had no apparent effect on increased vWF levels during exercise. Exercise induced a significant increase in the plasma thrombin-antithrombin III complex level with no significant changes in the level of plasmin-plasmin inhibitor complex level in all 3 groups.


CONCLUSIONS
Combined therapy with ASA + TIC effectively inhibited increased platelet aggregability in response to acute exercise, with no effects on coagulant or fibrinolytic potentials in patients with CAD. The data suggest that TIC combined with ASA may be superior to ASA alone in preventing acute coronary events during exercise in patients with coronary atherosclerotic disease.
Kitai
T
T
1st and 2nd Departments of Internal Medicine, Mie University School of Medicine, Tsu, Mie, Japan.
Nishikawa
M
M
Tanigawa
T
T
Okinaka
T
T
Wada
H
H
Shiku
H
H
Ikeda
Y
Y
Ito
M
M
Isaka
N
N
Nakano
T
T
D000227:Adenine Nucleotides / Q000097:blood*; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003327:Coronary Disease / Q000097:blood / Q000517:prevention & control*; D003328:Coronary Thrombosis / Q000097:blood / Q000517:prevention & control; D004334:Drug Administration Schedule; D015444:Exercise; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D013988:Ticlopidine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000227:Adenine Nucleotides; D010975:Platelet Aggregation Inhibitors; D013988:Ticlopidine; D001241:Aspirin