title: Regulation of Na+ channel distribution in the nervous system.
abstract: An important aspect of Na+ channel regulation is their distribution on neuronal membranes within the nervous system. The complexity of this process is brought by the molecular diversity of Na+ channels and differential regulation of their distribution. In addition, Na+ channel localization is a highly dynamic process depending on the status of the cell in vitro, and (patho)physiological condition of the organism in vivo. Nonetheless, the pharmacological manipulation of Na+ channel distribution should be possible and will hopefully bring safer and more-potent medicines in the future.
authors.affiliation: Roche Bioscience, Palo Alto, CA 94304-1397, USA. sanja.novakovic@roche.com
authors.forename: S D
authors.initials: SD
authors.lastname: Novakovic
authors.forename: R M
authors.initials: RM
authors.lastname: Eglen
authors.forename: J C
authors.initials: JC
authors.lastname: Hunter
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D009420:Nervous System / Q000378:metabolism*; D015222:Sodium Channels / Q000032:analysis* / Q000378:metabolism*
chemical_list: D015222:Sodium Channels