Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403.
The new serine protease inhibitor, ONO-3403 is an analog of FOY-305 (Foypan). The IC50s values of ONO-3403 toward serine proteases, such as trypsin, plasmin, kallikrein and thrombin are much lower than that of FOY-305. To investigate the growth-suppressing effect of ONO-3403 on 3-methylcholanthrene-induced autochthonous solid tumors in mice, ONO-3403 was intraperitoneally administered to mice at a dose of 4 mg/kg twice a day for 5 weeks. All seven mice receiving the drug had a solitary tumor and showed potent growth suppression (p<0.001) without any apparent side effects such as hair loss and body weight loss. The results suggest that ONO-3403 may be useful for the treatment of squamous cell carcinoma.
Ohkoshi
M
M
Branch Hospital, Department of Oral Surgery, Faculty of Medicine, The University of Tokyo, Japan.
Okuda
S
S
D016475:3T3 Cells; D000501:Allylglycine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001550:Benzamidines / Q000494:pharmacology*; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005260:Female; D005434:Flow Cytometry; D020128:Inhibitory Concentration 50; D008748:Methylcholanthrene; D051379:Mice; D008956:Models, Chemical; D012697:Serine Endopeptidases / Q000378:metabolism*; D012878:Skin Neoplasms / Q000188:drug therapy*; D013997:Time Factors
D000970:Antineoplastic Agents; D001550:Benzamidines; D002273:Carcinogens; D004791:Enzyme Inhibitors; C100807:ethyl N-allyl-N-(2-methyl-3-(4-(4-amidinophenoxycarbonyl)phenyl)propenoyl)aminoacetate methanesulfonate; D000501:Allylglycine; D008748:Methylcholanthrene; D012697:Serine Endopeptidases