Measuring glycated proteins: clinical and methodological aspects.
The recognition that nonenzymatic glycation, wherein free sugar condenses with certain reactive protein amino groups, is increased in hyperglycemic states has led to improved means for assessing diabetic control through the measurement of concentrations of glycated proteins in the circulation. This article reviews the chemistry, methods for measurement, and clinical relevance of circulating glycated proteins in the management of diabetes.
Cohen
M P
MP
Exocell, Inc., and Institute for Metabolic Research, University City Science Center, Philadelphia, Pennsylvania, USA. drmpcohen@aol.com
Clements
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RS
D000818:Animals; D015415:Biomarkers / Q000097:blood; D001798:Blood Proteins / Q000032:analysis* / Q000378:metabolism; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood* / Q000175:diagnosis*; D019270:Fructosamine / Q000097:blood; D017127:Glycation End Products, Advanced / Q000032:analysis; D006031:Glycosylation; D006801:Humans; D011499:Protein Processing, Post-Translational; D012709:Serum Albumin / Q000032:analysis; D000093423:Glycated Serum Albumin
D015415:Biomarkers; D001798:Blood Proteins; D017127:Glycation End Products, Advanced; D012709:Serum Albumin; D019270:Fructosamine; D000093423:Glycated Serum Albumin