title: In vitro studies of the anticalculus efficacy of an improved whitening dentifrice.
abstract: Crystal growth inhibition and plaque biofilm calcification laboratory studies were conducted to confirm the anticalculus potential of an enhanced cleaning and whitening dentifrice, based upon a novel enamel-safe, abrasive-polishing silica and pyrophosphate tartar control source with sodium fluoride as the anticaries ingredient. Calcium hydroxyapatite crystal growth following direct supernate treatments was significantly inhibited by the advanced whitening dentifrice. Similarly, plaque biofilm calcification was significantly inhibited by supernate treatments of the advanced whitening dentifrice. In both protocols, the advanced whitening dentifrice produced activity similar to formulations clinically proven for antitartar activity. These results provide support for the antitartar clinical activity of this new dentifrice.
authors.affiliation: Procter & Gamble Company, Health Care Research Center, Mason, OH, USA. White.DJ.1@pg.com
authors.forename: D J
authors.initials: DJ
authors.lastname: White
authors.forename: E R
authors.initials: ER
authors.lastname: Cox
mesh_terms: D018441:Biofilms; D002118:Calcium / Q000737:chemistry; D002327:Cariostatic Agents / Q000737:chemistry / Q000627:therapeutic use; D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D003728:Dental Calculus / Q000737:chemistry / Q000517:prevention & control*; D003743:Dental Enamel / Q000187:drug effects; D003773:Dental Plaque / Q000737:chemistry / Q000517:prevention & control; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D011756:Diphosphates / Q000737:chemistry / Q000627:therapeutic use; D017886:Durapatite / Q000737:chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012463:Saliva / Q000502:physiology; D012464:Saliva, Artificial / Q000737:chemistry; D012822:Silicon Dioxide / Q000737:chemistry / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000737:chemistry / Q000627:therapeutic use; D013395:Sucrose / Q000737:chemistry; D014073:Tooth Bleaching; D014075:Tooth Discoloration / Q000628:therapy
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D011756:Diphosphates; D012464:Saliva, Artificial; D013395:Sucrose; D012822:Silicon Dioxide; D012969:Sodium Fluoride; D017886:Durapatite; D002118:Calcium