In vitro activities of 10 antifungal drugs against 508 dermatophyte strains.
We have tested 508 strains belonging to 24 species of dermatophytes against 10 antifungal drugs following mainly the NCCLS (M38-P) standard for filamentous fungi. However, several important factors, such as the temperature (28 versus 35 degrees C) and time of incubation (4 to 10 days versus 21 to 74 h), have been modified. The antifungals used were itraconazole, ketoconazole, miconazole, clotrimazole, voriconazole, terbinafine, amphotericin B, fluconazole, UR-9825, and G-1. In general, with the exception of fluconazole and G-1, all antifungals were shown to be highly effective.
Fernández-Torres
B
B
Unitat de Microbiología, Facultat de Medicina and Institut d'Estudis Avançats, Universitat Rovira i Virgili, Reus, Spain.
Carrillo
A J
AJ
Martín
E
E
Del Palacio
A
A
Moore
M K
MK
Valverde
A
A
Serrano
M
M
Guarro
J
J
D000935:Antifungal Agents / Q000494:pharmacology*; D003883:Arthrodermataceae / Q000187:drug effects*; D006801:Humans; D017964:Itraconazole / Q000494:pharmacology; D007654:Ketoconazole / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000935:Antifungal Agents; D017964:Itraconazole; D008825:Miconazole; D007654:Ketoconazole