Treatment of canine hemangiopericytomas with photodynamic therapy.
OBJECTIVE
Canine hemangiopericytomas are a commonly occurring neoplasm with a clinical course of recurrence after surgical removal. This study sought to evaluate Photochlor (HPPH) photodynamic therapy (HPPH-PDT) as an adjuvant therapy to prevent recurrence of tumor after surgical removal.


METHODS
Sixteen dogs with naturally occurring hemangiopericytomas were treated with surgical removal of the tumor followed by PDT using Photochlor as the photosensitizer. Photochlor was injected intravenously at a dose of 0.3 mg/kg. Forty-eight hours later the treatment consisted of surgical removal of the tumor followed by HPPH-PDT.


RESULTS
Nine dogs (56%) had recurrence of tumor from 2 to 29 (median 9) months after treatment. These results are comparable or not as good as other forms of therapy.


CONCLUSIONS
Photochlor photodynamic therapy applied after surgery appears to have no advantage over other forms of therapy in regards to preventing recurrence. Delayed wound healing and infections are problematic and make HPPH-PDT an undesirable addition to surgery for the treatment of this tumor type.
McCaw
D L
DL
College of Veterinary Medicine, University of Missouri, Columbia, Missouri 65211, USA. mccawd@missouri.edu
Payne
J T
JT
Pope
E R
ER
West
M K
MK
Tompson
R V
RV
Tate
D
D
D000818:Animals; D002734:Chlorophyll / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy* / Q000601:surgery; D004285:Dogs; D005260:Female; D005552:Forelimb; D006393:Hemangiopericytoma / Q000188:drug therapy* / Q000601:surgery / Q000662:veterinary*; D006614:Hindlimb; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D010778:Photochemotherapy; D011182:Postoperative Care
D002734:Chlorophyll; C040298:pyropheophorbide a