title: The structure of physalin T from Physalis alkekengi var. franchetti.
abstract: A new steroidal constituent named physalin T (3) was isolated from the aqueous extract of Physalis alkekengi var. francheti. Based on 1H and 13C NMR spectral studies the structure was assigned as 2,3-dihydrophysalin D, i.e., 5alpha,6beta-dihydroxy-2,3,5,6-tetrahydrophysalin B, which is the first example of a natural physalin possessing a saturated ring A moiety. The structure was confirmed by the chemical transformation from the known physalin D (2) to physalin T.
authors.affiliation: Department of Applied Chemistry, Nagoya Institute of Technology, Japan. kawai@ach.nitech.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Kawai
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: B
authors.initials: B
authors.lastname: Makino
authors.forename: H
authors.initials: H
authors.lastname: Yamamura
authors.forename: S
authors.initials: S
authors.lastname: Araki
authors.forename: Y
authors.initials: Y
authors.lastname: Butsugan
authors.forename: K
authors.initials: K
authors.lastname: Saito
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007564:Japan; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012632:Secosteroids; D019657:Solanaceae / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*; D013329:Structure-Activity Relationship
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012632:Secosteroids; D013256:Steroids; C441429:physalin D; C441428:physalin T