Effects of beraprost sodium on canine cauda equina function and blood flow using a chronic spinal cord compression model.
Changes in blood flow after chronic compression were observed in 19 dogs after 10 mmHg compression for 1 week before and 1 hour after the intravenous administration of one of three doses of beraprost sodium (BPS; 30 ng x kg(-1) x min(-1), n = 7; 100 ng x kg(-1) x min(-1), n = 7; and 300 ng x kg(-1) x min(-1), n = 5). The speed of blood flow was calculated using a specially designed microscope equipped with a video camera. Dogs treated with BPS had lesser degrees of reduction in their nerve conduction velocity compared with controls. A vascular mechanism of injury likely explains why BPS-treated dogs had a lesser degree of reduction in their nerve conduction velocities compared with the control population.
Konno
S
S
Department of Orthopaedic Surgery, Fukushima Medical College, Fukushima City, Fukushima, Japan.
Arai
I
I
Otani
K
K
Olmarker
K
K
Kikuchi
S
S
D000818:Animals; D001783:Blood Flow Velocity / Q000187:drug effects; D002420:Cauda Equina / Q000098:blood supply* / Q000187:drug effects / Q000503:physiopathology*; D002908:Chronic Disease; D004285:Dogs; D011464:Epoprostenol / Q000031:analogs & derivatives / Q000494:pharmacology*; D009431:Neural Conduction / Q000187:drug effects; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects; D013117:Spinal Cord Compression / Q000503:physiopathology*; D013997:Time Factors; D014665:Vasodilator Agents / Q000494:pharmacology*
D014665:Vasodilator Agents; C048081:beraprost; D011464:Epoprostenol