title: Effect of enamel matrix derivative (EMDOGAIN) upon periodontal healing after replantation of permanent incisors in beagle dogs.
abstract: This study histologically assessed the effect of enamel matrix derivative (EMDOGAIN) on periodontal healing in re-implanted teeth in nine Beagle dogs. Incisors in dogs were re-implanted after 15, 30 and 60 min of dry storage with and without the application of EMDOGAIN. The pulps were removed in all teeth. In groups 1 and 2, dog teeth were splinted and the dogs sacrificed after 8 and 12 weeks, respectively. In group 3, dog teeth were not splinted and sacrifice took place after 12 weeks. The histological parameters studied were healed PDL, surface, inflammatory and replacement resorption. Univariable and multivariable analysis of data was performed. Increased incidence of healed PDL was inversely proportional to extraalveolar time. No significant differences were noticed between splinted and non-splinted teeth. The EMDOGAIN group showed a higher incidence of healed PDL, while controls showed a higher incidence of ankylosis. The effect of EMDOGAIN was more pronounced at the 12-week interval.
authors.affiliation: Department of Endodontics, School of Dental Medicine, University of Pennsylvania, 4001 Spruce Street, Philadelphia, PA 19104, USA. pennendo@hotmail.com
authors.forename: M K
authors.initials: MK
authors.lastname: Iqbal
authors.forename: N
authors.initials: N
authors.lastname: Bamaas
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D000844:Ankylosis / Q000209:etiology / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D003746:Dental Enamel Proteins / Q000627:therapeutic use*; D004285:Dogs; D005500:Follow-Up Studies; D015994:Incidence; D007180:Incisor / Q000293:injuries* / Q000601:surgery; D015999:Multivariate Analysis; D015588:Observer Variation; D010513:Periodontal Ligament / Q000187:drug effects* / Q000503:physiopathology; D010518:Periodontitis / Q000209:etiology / Q000473:pathology; D012038:Regeneration / Q000187:drug effects; D015203:Reproducibility of Results; D012390:Root Canal Therapy; D012391:Root Resorption / Q000209:etiology / Q000473:pathology; D013165:Splints; D013997:Time Factors; D014084:Tooth Avulsion / Q000503:physiopathology / Q000601:surgery*; D014090:Tooth Replantation; D020390:Tooth Socket / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects
chemical_list: D003746:Dental Enamel Proteins; C109069:enamel matrix proteins