MDM2: life without p53.
The MDM2 protein suppresses the ability of p53 to inhibit cellular proliferation or to induce cell death. This property underlies the oncogenic potential of MDM2, which is overexpressed in various human tumours. However, MDM2 also has p53-independent activities, which we focus on here. Similar to other oncogenes, surveillance pathways might counteract the deleterious effects of deregulated MDM2 expression. These pathways need to be inactivated for MDM2 oncogenic activity, which targets p53 but also other proteins.
Daujat
S
S
The Wellcome Trust and Cancer Research Campaign Institute of Cancer, Tennis Court Road, Cambridge, UK CB2 1QR.
Neel
H
H
Piette
J
J
D016475:3T3 Cells; D000818:Animals; D018797:Cell Cycle Proteins; D016923:Cell Death; D002455:Cell Division; D004268:DNA-Binding Proteins / Q000378:metabolism; D050684:E2F Transcription Factors; D016147:Genes, Tumor Suppressor; D006801:Humans; D051379:Mice; D008954:Models, Biological; D008957:Models, Genetic; D009687:Nuclear Proteins / Q000378:metabolism; D011485:Protein Binding; D011518:Proto-Oncogene Proteins / Q000378:metabolism* / Q000502:physiology; D051736:Proto-Oncogene Proteins c-mdm2; D014157:Transcription Factors / Q000378:metabolism; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism; D025521:Tumor Suppressor Proteins
D018797:Cell Cycle Proteins; D004268:DNA-Binding Proteins; D050684:E2F Transcription Factors; D009687:Nuclear Proteins; D011518:Proto-Oncogene Proteins; D014157:Transcription Factors; C000606368:Trp73 protein, mouse; D000072160:Tumor Protein p73; D016159:Tumor Suppressor Protein p53; D025521:Tumor Suppressor Proteins; C497206:MDM2 protein, human; C497207:Mdm2 protein, mouse; D051736:Proto-Oncogene Proteins c-mdm2