title: [The biological effects of recombinant human osteogenic protein-1 to cultured pulp cells].
abstract: The study was to observe the biological effects of rhOP-1 on the proliferation, ALPase activity and osteocalcin of dental pulp cells by cell culture technique, MTT, enzyme kinetic methods and radioimmunoassay. The results indicated rhOP-1 could obviously promote the proliferation and enhanced ALPase activity and osteocalcin secretion of pulp cells with showing dose-dependent relationship in this experimental dose range. Thus, rhOP-1 can induce dental pulp cells to differentiate the cells expressing osteoblast phenotype.
authors.affiliation: College of Stomatology, West China University of Medical Sciences, China.
authors.forename: Q
authors.initials: Q
authors.lastname: Su
authors.forename: G
authors.initials: G
authors.lastname: He
authors.forename: Y
authors.initials: Y
authors.lastname: Sun
authors.forename: H
authors.initials: H
authors.lastname: Lu
authors.forename: S
authors.initials: S
authors.lastname: Wang
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins / Q000494:pharmacology*; D002455:Cell Division; D002478:Cells, Cultured; D003782:Dental Pulp / Q000166:cytology / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D015675:Osteocalcin / Q000378:metabolism*; D016212:Transforming Growth Factor beta / Q000494:pharmacology
chemical_list: C525819:BMP7 protein, human; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D016212:Transforming Growth Factor beta; D015675:Osteocalcin; D000469:Alkaline Phosphatase