Haemophilus influenzae type b serology in childhood leukaemia: a case-control study.
Antibody to Haemophilus influenzae type b (Hib) polysaccharide (PRP) was measured in 42 children with acute lymphoblastic leukaemia (ALL) and 42 non-leukaemic hospital controls. Modelling anti-PRP concentrations as a function of age revealed that the slopes of the trend lines differed significantly between cases and controls (P = 0.05); anti-PRP concentrations were lower among younger cases, and higher among older cases, than among controls of the same ages.
Groves
F D
FD
Department of Biometry and Epidemiology, Medical University of South Carolina, Charleston, South Carolina, USA.
Sinha
D
D
Kayhty
H
H
Goedert
J J
JJ
Levine
P H
PH
D000293:Adolescent; D000914:Antibodies, Viral / Q000097:blood*; D000956:Antigens, Viral / Q000276:immunology; D016667:Bacterial Capsules; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D005260:Female; D006192:Haemophilus Infections / Q000276:immunology*; D018073:Haemophilus Vaccines / Q000276:immunology; D019741:Haemophilus influenzae type b / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007223:Infant; D008297:Male; D011135:Polysaccharides, Bacterial / Q000276:immunology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology*
D000914:Antibodies, Viral; D000956:Antigens, Viral; D018073:Haemophilus Vaccines; C044237:Haemophilus influenzae type b polysaccharide vaccine; D011135:Polysaccharides, Bacterial