Successful mismatched sibling cord blood transplant in Hb Bart's disease.
A 20-month-old girl with Hb Bart's disease, who had survived neonatal complications, underwent HLA-DR antigen mismatched sibling cord blood transplantation successfully. Immune thrombocytopenia, which occurred around 2.5 months after transplant, responded to intravenous gamma-globulin. The fetal hemoglobin level rose to a peak of 52.3% on day +69 post transplant and declined gradually during the following year. Ten percent of hemoglobin Bart's was detected 2 months after transplant and this reflects the alpha-thalassemia trait of the donor.
Zhou
X
X
Department of Pediatrics, The University of Hong Kong, Queen Mary Hospital, Hong Kong SAR, China.
Ha
S Y
SY
Chan
G C
GC
Luk
C W
CW
Chan
V
V
Hawkins
B
B
Lam
Y H
YH
Liang
R H
RH
Lau
Y L
YL
D005260:Female; D005312:Fetal Blood; D006085:Graft Survival; D006684:HLA-DR Antigens; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods*; D006453:Hemoglobinopathies / Q000097:blood / Q000150:complications / Q000628:therapy; D006455:Hemoglobins, Abnormal; D006648:Histocompatibility / Q000276:immunology*; D006801:Humans; D007223:Infant; D009679:Nuclear Family; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000188:drug therapy / Q000209:etiology; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000276:immunology / Q000379:methods; D017085:alpha-Thalassemia / Q000097:blood / Q000150:complications / Q000628:therapy
D006684:HLA-DR Antigens; D006455:Hemoglobins, Abnormal; C030448:hemoglobin Bart's