title: Pharmaco-toxicological screening of commercially available Italian natural mineral waters.
abstract: The consumption of natural mineral water has increased enormously during the past few years, yet doubts are arising about the real utility of using such water instead of ordinary drinking water (tap water). Mineral water's 'special' mineral composition might have properties favourable to health, which should be assessed by clinical and pharmacological analyses. A comparative pharmaco-toxicological study was performed on 14 commercially available Italian natural mineral waters with a wide range of mineral content. The waters were microbiologically analysed and the Allium cepa test done; in addition, Irwin, charcoal meal and diuresis tests were also performed on laboratory animals. No toxicological signs were recorded at the Allium cepa assay for any but the water with the highest mineral content. The diuretic effect was comparable to that of control tap water. Waters with high magnesium content significantly enhanced intestinal motility while at the Irwin test none of the water samples evoked behavioural changes. All the tested samples were microbiologically pure. In conclusion, mineral water can be an alternative to aqueduct water in places where the latter comes from superficial water and has to be subjected to hard potabilisation techniques; water from the 'Acqua Marcia' aqueduct (control) was found to have characteristics comparable to the mineral waters studied.
authors.affiliation: Department of Pharmacology and Physiology, School of Pharmacy, University of Rome La Sapienza, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Evandri
authors.forename: P
authors.initials: P
authors.lastname: Bolle
mesh_terms: D000490:Allium; D000818:Animals; D002606:Charcoal; D004231:Diuresis / Q000187:drug effects; D007558:Italy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008900:Mineral Waters / Q000633:toxicity*; D014871:Water Microbiology
chemical_list: D008900:Mineral Waters; D002606:Charcoal