title: Function of Hrs in endocytic trafficking and signalling.
abstract: The hepatocyte growth factor-regulated tyrosine kinase substrate, Hrs, becomes tyrosine-phosphorylated upon the binding of various growth factors and cytokines to their receptors. This protein is essential for ventral folding morphogenesis, and it shares structural similarity with Vps27p, which is involved in vacuolar protein sorting in yeast. Since Hrs is localized to endosomes and has been implicated in the regulation of signal transduction as well as membrane trafficking, it has been regarded as a potential co-ordinator of endosomal receptor sorting and signalling. Here we discuss the possible functions of Hrs in light of its interactions with phosphatidylinositol 3-phosphate and multiple proteins.
authors.affiliation: Department of Biochemistry, Norwegian Radium Hospital, Montebello, N-0310 Oslo, Norway.
authors.forename: C
authors.initials: C
authors.lastname: Raiborg
authors.forename: K G
authors.initials: KG
authors.lastname: Bache
authors.forename: A
authors.initials: A
authors.lastname: Mehlum
authors.forename: H
authors.initials: H
authors.lastname: Stenmark
mesh_terms: D000595:Amino Acid Sequence; D001665:Binding Sites; D017124:Conserved Sequence; D004705:Endocytosis / Q000502:physiology*; D056827:Endosomal Sorting Complexes Required for Transport; D011992:Endosomes / Q000502:physiology; D007425:Intracellular Membranes / Q000502:physiology; D010750:Phosphoproteins / Q000737:chemistry / Q000378:metabolism*; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D015398:Signal Transduction / Q000502:physiology*; D013574:Synaptosomes / Q000502:physiology
chemical_list: D056827:Endosomal Sorting Complexes Required for Transport; D010750:Phosphoproteins; C096164:hepatocyte growth factor-regulated tyrosine kinase substrate; D011505:Protein-Tyrosine Kinases