title: Pulmonary complications in cardiac transplant recipients.
abstract: BACKGROUND
  The incidence of pulmonary complications in heart transplant recipients has not been extensively studied. We report pulmonary complications in 159 consecutive adult orthotopic heart transplantations (OHTs) performed in 157 patients.
  
  
  METHODS
  Retrospective review of medical records.
  
  
  RESULTS
  Forty-seven of 159 recipients (29.9%) had 81 pulmonary complications. Pneumonia was the most common (n = 27), followed by bronchitis (n = 15), pleural effusion (n = 10), pneumothorax (n = 7), prolonged respiratory failure requiring tracheotomy (n = 7), and obstructive sleep apnea syndrome (n = 6). All patients with late-onset (> 6 months after transplantation) community-acquired bacterial pneumonia presented with fever, cough, and a new lobar consolidation on the chest radiograph, and responded promptly to empiric antibiotics without undergoing an invasive diagnostic procedure. In contrast, early-onset nosocomial bacterial pneumonias carried a 33.3% mortality rate. A positive tuberculin skin test result was associated with a significantly higher rate of pulmonary complications (62.5% vs 26.8%, p = 0.007). Lung cancer and posttransplant lymphoproliferative disorder (PTLD) developed exclusively in 6 of the 61 patients (8.1%) who received induction immunosuppression with murine monoclonal antibody (OKT3).
  
  
  CONCLUSIONS
  Pulmonary complications are common following heart transplantation, occurring in 29.9% of recipients, and are attributed to pneumonia of primarily bacterial origin in one half of cases. Late-onset community-acquired pneumonia carried an excellent prognosis following empiric antibiotic therapy, suggesting that in the appropriate clinical setting invasive diagnostic procedures are unnecessary. Analogous to reports in other solid-organ transplant recipients, induction therapy with OKT3 was associated with an increased incidence of lung cancer and PTLD. Overall, the development of pulmonary complications after OHT has prognostic significance given the higher mortality in this subset of patients.
authors.affiliation: Bronx VA Medical Center and NYU-Mount Sinai Medical Center, New York, NY, USA.
authors.forename: R
authors.initials: R
authors.lastname: Lenner
authors.forename: M L
authors.initials: ML
authors.lastname: Padilla
authors.forename: A S
authors.initials: AS
authors.lastname: Teirstein
authors.forename: A
authors.initials: A
authors.lastname: Gass
authors.forename: G J
authors.initials: GJ
authors.lastname: Schilero
mesh_terms: D001991:Bronchitis / Q000209:etiology; D005260:Female; D016027:Heart Transplantation; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010996:Pleural Effusion / Q000209:etiology; D011014:Pneumonia / Q000209:etiology; D011030:Pneumothorax / Q000209:etiology; D011183:Postoperative Complications; D012131:Respiratory Insufficiency / Q000209:etiology; D012189:Retrospective Studies; D020181:Sleep Apnea, Obstructive / Q000209:etiology