Concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol in a lethal case involving zuclopenthixol, diazepam, and cyamemazine.
cis(Z)-Clopenthixol and trans(E)-clopenthixol were determined by gas chromatography-mass spectrometry and high-performance liquid chromatography-diode-array detection in necropic samples from a postmortem case. The peripheral blood concentrations of cis(Z)-clopenthixol and trans(E)-clopenthixol were 278 and 177 ng/mL, respectively. The level of the active cis(Z)-isomer is within the toxic range. Other associated drugs' concentrations were within their therapeutic ranges. Postmortem redistribution of the drug and instability of the drug due to trans-isomerization were discussed.
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Laboratoire de Police Scientifique, Section Toxicologie, Marseille, France.
D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects* / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D003006:Clopenthixol / Q000009:adverse effects* / Q000097:blood*; D003975:Diazepam / Q000009:adverse effects* / Q000097:blood; D004338:Drug Combinations; D062787:Drug Overdose; D017809:Fatal Outcome; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007536:Isomerism; D008297:Male; D010640:Phenothiazines / Q000009:adverse effects* / Q000097:blood
D014150:Antipsychotic Agents; D004338:Drug Combinations; D010640:Phenothiazines; D003006:Clopenthixol; C028457:cyamemazine; D003975:Diazepam