Formulation and stability testing of photolabile drugs.
Exposure of a drug to irradiation can influence the stability of the formulation, leading to changes in the physicochemical properties of the product. The influence of excipients of frequently used stabilizers is often difficult to predict and, therefore, stability testing of the final preparation is important. The selection of a protective packaging must be based on knowledge about the wavelength causing the instability. Details on drug photoreactivity will also be helpful in order to minimize side-effects and/or optimize drug targeting by developing photoresponsive drug delivery systems. This review focuses on practical problems related to formulation and stability testing of photolabile drugs.
Tønnesen
H H
HH
Institute of Pharmacy, University of Oslo, PO Box 1068 Blindern, 0316, Oslo, Norway. h.h.tonnesen@farmasi.uio.no
D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005079:Excipients / Q000528:radiation effects; D010777:Photochemistry
D005079:Excipients