title: Effect of monthly intravenous cyclophosphamide in rapidly deteriorating multiple sclerosis patients resistant to conventional therapy.
abstract: Fourteen consecutive clinically definite relapsing-remitting multiple sclerosis (MS) patients were treated with monthly intravenous cyclophosphomide (CTX) for 6 months. All had experienced severe dinical deterioration during the 12 months prior to treatment with CTX despite treatment with conventional immunomodulating agents and intravenous methylprednisolone. Treatment with CTX led to improvement and neurologic stability within 6 months which was sustained for at least 18 months after the onset of treatment with CTX. Therapy with CTX was well tolerated. CTX may be of benefit in MS patients who experience rapid clinical worsening and are resistant to conventional therapy.
authors.affiliation: Multiple Sclerosis Center, Department of Neurology, Wayne State University School of Medicine, Detroit, USA.
authors.forename: O A
authors.initials: OA
authors.lastname: Khan
authors.forename: M
authors.initials: M
authors.lastname: Zvartau-Hind
authors.forename: C
authors.initials: C
authors.lastname: Caon
authors.forename: M U
authors.initials: MU
authors.lastname: Din
authors.forename: M
authors.initials: M
authors.lastname: Cochran
authors.forename: D
authors.initials: D
authors.lastname: Lisak
authors.forename: A C
authors.initials: AC
authors.lastname: Tselis
authors.forename: J A
authors.initials: JA
authors.lastname: Kamholz
authors.forename: J Y
authors.initials: JY
authors.lastname: Garbern
authors.forename: R P
authors.initials: RP
authors.lastname: Lisak
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000188:drug therapy*; D016896:Treatment Outcome
chemical_list: D007166:Immunosuppressive Agents; D003520:Cyclophosphamide