title: Case report of pallido-pyramidal disease with supplementary motor area involvement.
abstract: An C-flumazenil positron emission tomography (PET) study in a patient with pallido-pyramidal disease revealed a marked decrease in benzodiazepine-receptor density in the precentral gyrus cortex and the mesial frontal cortex. We suggest that, in addition to dysfunction of basal ganglia-dependent systems, degeneration of the supplementary motor area could also be involved in the patient's bradykinesia.
authors.affiliation: Fédération de Neurologie Mazarin, Hôpital de la Pitié-Salpétrière, Paris, France.
authors.forename: P F
authors.initials: PF
authors.lastname: Pradat
authors.forename: C
authors.initials: C
authors.lastname: Dupel-Pottier
authors.forename: L
authors.initials: L
authors.lastname: Lacomblez
authors.forename: F
authors.initials: F
authors.lastname: Salachas
authors.forename: V
authors.initials: V
authors.lastname: Meininger
authors.forename: L
authors.initials: L
authors.lastname: Lacomblez
authors.forename: L
authors.initials: L
authors.lastname: Spelle
authors.forename: I
authors.initials: I
authors.lastname: Bonnaud
authors.forename: M J
authors.initials: MJ
authors.lastname: Ribeiro
authors.forename: P
authors.initials: P
authors.lastname: Remy
authors.forename: Y
authors.initials: Y
authors.lastname: Samson
mesh_terms: D000328:Adult; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D001931:Brain Mapping; D003241:Consanguinity; D004292:Dominance, Cerebral / Q000502:physiology; D005442:Flumazenil; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D005917:Globus Pallidus / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D009044:Motor Cortex / Q000000981:diagnostic imaging*; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging*; D011963:Receptors, GABA-A / Q000378:metabolism; D014055:Tomography, Emission-Computed
chemical_list: D011963:Receptors, GABA-A; D005442:Flumazenil