Transcriptional regulation by the phosphorylation-dependent factor CREB.
The transcription factor CREB -- for 'cyclic AMP response element-binding protein' -- functions in glucose homeostasis, growth-factor-dependent cell survival, and has been implicated in learning and memory. CREB is phosphorylated in response to various signals, but how is specificity achieved in these signalling pathways?
Mayr
B
B
Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, California 92037, USA.
Montminy
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M
D051697:Activating Transcription Factor 1; D017398:Alternative Splicing; D000818:Animals; D001665:Binding Sites; D000242:Cyclic AMP / Q000502:physiology; D051786:Cyclic AMP Response Element Modulator; D017362:Cyclic AMP Response Element-Binding Protein / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000502:physiology; D019175:DNA Methylation; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology; D005786:Gene Expression Regulation / Q000502:physiology*; D016356:Gene Products, tax / Q000502:physiology; D006133:Growth Substances / Q000502:physiology; D015368:Human T-lymphotropic virus 1 / Q000235:genetics; D016350:Leucine Zippers; D046911:Macromolecular Substances; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D008957:Models, Genetic; D008958:Models, Molecular; D005810:Multigene Family; D009687:Nuclear Proteins / Q000502:physiology; D010766:Phosphorylation; D011487:Protein Conformation; D011499:Protein Processing, Post-Translational; D012045:Regulatory Sequences, Nucleic Acid; D012097:Repressor Proteins; D015290:Second Messenger Systems / Q000502:physiology; D013312:Stress, Physiological / Q000235:genetics / Q000378:metabolism; D015534:Trans-Activators / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic
D051697:Activating Transcription Factor 1; C497100:Atf1 protein, mouse; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; D016356:Gene Products, tax; D006133:Growth Substances; D046911:Macromolecular Substances; D009687:Nuclear Proteins; D012097:Repressor Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D051786:Cyclic AMP Response Element Modulator; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases