title: Prediction of severe disseminated adenovirus infection by serum PCR.
abstract: Adenoviruses are increasingly recognised as viral pathogens that can cause fatal infections in immunocompromised patients, particularly recipients of haematopoietic stem-cell grafts. Adenovirus infections are not easily diagnosed and the development of a severe infection cannot be predicted by standard culture techniques. In a pilot study, we investigated the value of adenovirus DNA detection in serum as a marker of disseminated disease in 14 patients with defined patterns of adenovirus infections. The results show that the appearance of adenoviral DNA in serum preceded the development of a severe or fatal adenovirus infection. Because proper management is dependent on early diagnosis and differentiation from other conditions, this test may be a valuable tool in the management of adenovirus infection.
authors.forename: M
authors.initials: M
authors.lastname: Echavarria
authors.forename: M
authors.initials: M
authors.lastname: Forman
authors.forename: M J
authors.initials: MJ
authors.lastname: van Tol
authors.forename: J M
authors.initials: JM
authors.lastname: Vossen
authors.forename: P
authors.initials: P
authors.lastname: Charache
authors.forename: A C
authors.initials: AC
authors.lastname: Kroes
mesh_terms: D000258:Adenovirus Infections, Human / Q000175:diagnosis*; D000260:Adenoviruses, Human / Q000302:isolation & purification*; D004279:DNA, Viral / Q000097:blood*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D010865:Pilot Projects; D016133:Polymerase Chain Reaction; D011237:Predictive Value of Tests
chemical_list: D004279:DNA, Viral