Determination of degradation products of sumatriptan succinate using LC-MS and LC-MS-MS.
Acid, base, heat, oxidation and UV irradiation stress methods were applied to study the stability of the bulk drug form of sumatriptan succinate. Liquid chromatography coupled with mass spectrometry (LC-MS and LC-MS-MS) was used to analyze the degraded samples and tentative structural identifications were assigned based upon known reactivity of the drug, molecular weight measurements and MS-MS fragmentation patterns. Sumatriptan succinate was found to be stable to exposure of acid, base, oxidation and UV irradiation at ambient conditions, but was found to degrade under acidic, basic and oxidative conditions when heated to 90 degrees C.
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Department of Pharmaceutical & Biomedical Sciences, College of Pharmacy, The University of Georgia, Athens, GA 30602-2352, USA.
Bartlett
M G
MG
Stewart
J T
JT
D002853:Chromatography, Liquid; D004355:Drug Stability; D013058:Mass Spectrometry; D017366:Serotonin Receptor Agonists / Q000737:chemistry*; D018170:Sumatriptan / Q000032:analysis / Q000737:chemistry*
D017366:Serotonin Receptor Agonists; D018170:Sumatriptan