[Efficacy and safety of intravenously administered pantoprazole in the treatment of gastrinoma].
The efficacy and safety of the proton pump inhibitor pantoprazole (P) in patients with Zollinger-Ellison syndrome (ZES) is well documented. We treated 21 patients with ZES with intravenous P; 13 of these patients were treated surgically in advance. The effect of P was very rapid, with reduction of the acid output within 15 min and its normalization within 60 min. The control of gastric acid secretion was maintained for a mean of 10.9 hours after the infusion of P. We conclude that the use of intravenous P allows a safe and efficient control of the acid ipersecretion in patients with ZES.
Modlin
I M
IM
Department of Gastroenterology, Yale University, New Haven, USA.
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000188:drug therapy* / Q000503:physiopathology; D009853:Omeprazole / Q000031:analogs & derivatives; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000503:physiopathology* / Q000601:surgery; D000077402:Pantoprazole; D013454:Sulfoxides / Q000008:administration & dosage* / Q000494:pharmacology; D013997:Time Factors; D015043:Zollinger-Ellison Syndrome / Q000188:drug therapy* / Q000503:physiopathology* / Q000601:surgery
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D004791:Enzyme Inhibitors; D013454:Sulfoxides; D000077402:Pantoprazole; D009853:Omeprazole