title: Preparation of 2,5-disubstituted oxazoles from N-propargylamides.
abstract: [reaction: see text] 2,5-Disubstituted oxazoles have been prepared through the reaction of N-propargylamides with aryl iodides in the presence of Pd(2)(dba)(3), tri(2-furyl)phosphine, and NaO(t)()Bu. The reaction appears to proceed through a palladium-catalyzed coupling step followed by the in situ cyclization of the resultant coupling product.
authors.affiliation: Dipartimento di Chimica Ingegneria Chimica e Materiali della Facoltà di Scienze, Università de L'Aquila, Via Vetoio, Coppito Due, I-67100 L'Aquila, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Arcadi
authors.forename: S
authors.initials: S
authors.lastname: Cacchi
authors.forename: L
authors.initials: L
authors.lastname: Cascia
authors.forename: G
authors.initials: G
authors.lastname: Fabrizi
authors.forename: F
authors.initials: F
authors.lastname: Marinelli
mesh_terms: D000577:Amides / Q000138:chemical synthesis*; D002384:Catalysis; D003500:Cyclization; D007202:Indicators and Reagents; D010080:Oxazoles / Q000138:chemical synthesis*; D010165:Palladium / Q000737:chemistry; D010293:Pargyline / Q000031:analogs & derivatives* / Q000138:chemical synthesis*; D012997:Solvents
chemical_list: D000577:Amides; D007202:Indicators and Reagents; D010080:Oxazoles; D012997:Solvents; D010165:Palladium; D010293:Pargyline