title: Investigational antifungal agents.
abstract: Several new antifungal agents, including novel compounds in familiar classes and entirely new classes targeting previously untapped mechanisms, are in various stages of the drug development process. Many new triazole antifungal agents are being studied, including voriconazole, posaconazole, and ravuconazole. The echinocandin antifungals, which represent a new class of antifungal agents, possess activity against a variety of fungal pathogens. The sodarin derivatives and nikkomycins are two additional classes of antifungals in early stages of development; future studies will determine their therapeutic usefulness.
authors.affiliation: College of Pharmacy, University of Iowa, Iowa City 52242-1112, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Ernst
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D001230:Aspergillus / Q000145:classification / Q000187:drug effects; D002175:Candida / Q000145:classification / Q000187:drug effects; D015507:Drugs, Investigational / Q000737:chemistry / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D008826:Microbial Sensitivity Tests
chemical_list: D000935:Antifungal Agents; D015507:Drugs, Investigational