Prognostic significance of the endothelial surface in low-grade resected oligodendrogliomas.
The importance of angiogenesis as a prognostic factor in brain tumours has recently been reported. In this study, we analysed the long-term prognostic significance of a morphometric score expressing the endothelial area for every 1000 tumour cells, in tumour tissue from 26 patients with a low-grade oligodendroglioma that has been treated surgically and irradiated, and has a MIB-1 labelling index (MIB-1 LI) of less than 1%. In each tumour, a vascular endothelial surface index (VESI) was determined as the CD-34 immunostained endothelial area in micron 2 per 1000 tumour cells. Patients with a VESI of less than 15 (n = 12) showed a survival at 5 and 10 years of 100 and 71%, respectively, versus a survival of 50 and 0% for patients presenting a VESI greater than 15 (n = 14); p < 0.05). Our present findings suggest the usefulness of VESI as a long-term prognostic pathological factor in low-grade oligodendroglioma.
Vaquero
J
J
Laboratory of Experimental Neuro-oncology, Neuroscience Research Unit of the Mapfre-Medicine Foundation & Neurosurgical Service, Puerta de Hierro Clinic Hospital, Autonomous University, Madrid, Spain.
Zurita
M
M
Morales
C
C
Coca
S
S
D000293:Adolescent; D000328:Adult; D015415:Biomarkers / Q000097:blood; D001932:Brain Neoplasms / Q000098:blood supply* / Q000175:diagnosis*; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D009837:Oligodendroglioma / Q000098:blood supply* / Q000175:diagnosis*; D011379:Prognosis; D015996:Survival Rate
D015415:Biomarkers