[Comparative study on effect of Panax notoginseng and ticlid in treating early diabetic nephropathy].
OBJECTIVE
To explore the ameliorative effect and mechanism of Panax notoginseng (PNG) and ticlid in treating early diabetic nephropathy (DN).


METHODS
Fifty-eight patients were divided randomly into two groups, 28 patients of the ticlid group treated with ticlid 250 mg orally, once a day and 30 patients of the PNG group treated with PNG 8 ml in 250 ml of normal saline intravenous drip once a day. The therapeutic effect and relative indexes of the two groups were observed and compared.


RESULTS
After treatment, in both groups, the thromboxane B2 markedly reduced and was more prominent in the ticlid group (P < 0.05), while the 6-keto-prostaglandin F1 alpha increased obviously, so as to cause a significant lowering of T/K ratio, P < 0.01. Levels of urinary albumin, beta 2 microglobulin and blood alpha 1 microglobulin of both groups were lowered significantly, P < 0.01. A significant positive linear correlation was found in the ticlid group between urinary albumin and T/K ratio (r = 0.41, P < 0.01), as well as in blood alpha 1 microglobulin with T/K ratio (r = 0.34, P < 0.05), while it was not found in the PNG group.


CONCLUSIONS
Ticlid and PNG were beneficial to resume the balance of T/K and improve microcirculation, reduce whole blood viscosity and decrease urinary albumin so as to retard the progress of DN.
Lang
J
J
Foshan TCM Hospital, Guangdong 528000.
Cao
H
H
Wei
A
A
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood; D000328:Adult; D003928:Diabetic Nephropathies / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D036145:Ginsenosides; D006801:Humans; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D012503:Saponins / Q000627:therapeutic use*; D013929:Thromboxane B2 / Q000097:blood; D013988:Ticlopidine / Q000627:therapeutic use
D004365:Drugs, Chinese Herbal; D036145:Ginsenosides; D010975:Platelet Aggregation Inhibitors; C027816:San-Chi; D012503:Saponins; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D013988:Ticlopidine; C035054:ginsenoside Rg1