title: Cognitive-behavioral management of patients with bipolar disorder who relapsed while on lithium prophylaxis.
abstract: BACKGROUND
  The application of cognitive-behavioral treatment (CBT) to patients with bipolar disorder who had an affective episode while on lithium prophylaxis has received little research attention. The aim of this preliminary study was to test whether reduction of residual symptomatology by cognitive-behavioral methods could yield long-term beneficial effects in patients with bipolar disorder, as was found to be the case in recurrent unipolar depression.
  
  
  METHODS
  Fifteen patients with RDC bipolar disorder, type I, who relapsed while on lithium prophylaxis despite initial response and adequate compliance were treated by cognitive-behavioral methods in an open trial. A 2- to 9-year follow-up was performed.
  
  
  RESULTS
  Five of the 15 patients had a new affective episode during follow-up. CBT was associated with a significant reduction of residual symptomatology.
  
  
  CONCLUSIONS
  These preliminary results suggest that a trial of CBT may enhance lithium prophylaxis and improve long-term outcome of bipolar disorder.
authors.affiliation: Department of Psychiatry, State University of New York at Buffalo, USA.
authors.forename: G A
authors.initials: GA
authors.lastname: Fava
authors.forename: G
authors.initials: G
authors.lastname: Bartolucci
authors.forename: C
authors.initials: C
authors.lastname: Rafanelli
authors.forename: L
authors.initials: L
authors.lastname: Mangelli
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D001714:Bipolar Disorder / Q000188:drug therapy / Q000517:prevention & control* / Q000628:therapy*; D015928:Cognitive Behavioral Therapy; D004334:Drug Administration Schedule; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008094:Lithium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D055502:Secondary Prevention; D016896:Treatment Outcome
chemical_list: D008094:Lithium