The structure of McN-5652.
The configuration of the diastereoisomers of 6-(4-methylthiophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline 1 (McN-5652) is determined and unequivocally assigned by NMR spectroscopy (NOE measurements) and an X-ray structural analysis of the trans diastereoisomer. The enantiomers of cis-1 are separated by preparative HPLC on a chiral phase. One of the enantiomers of cis-1 represents the precursor for imaging the serotonin 5-HT transporter with positron emission tomography (PET).
Schulze
O
O
Institut für Organische Chemie der Universität Hamburg, Martin-Luther-King-Platz 6, 20146, Hamburg, Germany.
Schmidt
U
U
Voss
J
J
Nebeling
B
B
Adiwidjaja
G
G
Scharwächter
K
K
D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D007546:Isoquinolines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012702:Serotonin Antagonists / Q000737:chemistry*
D007546:Isoquinolines; D012702:Serotonin Antagonists; C058079:McN 5652