title: Mycobacterium tuberculosis: here today, and here tomorrow.
abstract: Mycobacterium tuberculosis is a highly successful pathogen that parasitizes the macrophages of its host. Its success can be attributed directly to its ability to manipulate the phagosome that it resides in and to prevent the normal maturation of this organelle into an acidic, hydrolytic compartment. As the macrophage is key to clearing the infection, the interplay between the pathogen and its host cell reflects a constant battle for control.
authors.affiliation: Microbiology and Immunology, 5173 Veterinary Medical Center, Cornell University, Ithaca, New York 14853, USA. dgr8@cornell.edu
authors.forename: D G
authors.initials: DG
authors.lastname: Russell
mesh_terms: D000328:Adult; D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use; D001500:BCG Vaccine; D002147:Calmodulin / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D027682:Cation Transport Proteins; D002412:Cations / Q000378:metabolism; D002648:Child; D015195:Drug Design; D011992:Endosomes / Q000382:microbiology / Q000502:physiology; D006681:HLA-D Antigens / Q000276:immunology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007425:Intracellular Membranes / Q000502:physiology; D017136:Ion Transport; D007522:Isocitrate Lyase / Q000172:deficiency / Q000235:genetics / Q000502:physiology; D008055:Lipids / Q000502:physiology; D008247:Lysosomes / Q000737:chemistry; D016676:Macrophages, Alveolar / Q000201:enzymology / Q000382:microbiology* / Q000648:ultrastructure; D008561:Membrane Fusion; D008565:Membrane Proteins / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D009162:Mycobacterium avium / Q000502:physiology; D015270:Mycobacterium avium-intracellulare Infection / Q000276:immunology / Q000382:microbiology / Q000473:pathology; D009163:Mycobacterium bovis / Q000502:physiology; D009169:Mycobacterium tuberculosis / Q000276:immunology / Q000502:physiology*; D010588:Phagosomes / Q000382:microbiology / Q000502:physiology; D014168:Transferrin / Q000378:metabolism; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology* / Q000473:pathology; D014617:Vacuoles / Q000382:microbiology; D000099173:Natural Resistance-associated Macrophage Protein 1
chemical_list: D000995:Antitubercular Agents; D001500:BCG Vaccine; D002147:Calmodulin; D002352:Carrier Proteins; D027682:Cation Transport Proteins; D002412:Cations; D006681:HLA-D Antigens; D007522:Isocitrate Lyase; D008055:Lipids; D008565:Membrane Proteins; D014168:Transferrin; D000099173:Natural Resistance-associated Macrophage Protein 1; C008901:phthiocerol dimycocerosate