title: Preventing antiretroviral anarchy in sub-Saharan Africa.
abstract: Combination antiretroviral therapy has dramatically improved the survival of patients living with HIV and AIDS in industrialised countries of the world. Despite this enormous benefit, there are some major problems and obstacles to be overcome.(1) Treatment of HIV-infection is likely to be lifelong.(2) Unfortunately, many HIV-infected individuals cannot tolerate the toxic effects of the drugs, or have difficulty complying with treatment which involves large numbers of pills and complicated dosing schedules. Poor adherence to treatment leads to the emergence of drug-resistant viral strains that need new combinations of drugs or new drugs altogether.
authors.affiliation: National Tuberculosis Control Programme, Community Health Science Unit, Lilongwe, Malawi. adharries@malawi.net
authors.forename: A D
authors.initials: AD
authors.lastname: Harries
authors.forename: D S
authors.initials: DS
authors.lastname: Nyangulu
authors.forename: N J
authors.initials: NJ
authors.lastname: Hargreaves
authors.forename: O
authors.initials: O
authors.lastname: Kaluwa
authors.forename: F M
authors.initials: FM
authors.lastname: Salaniponi
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy* / Q000453:epidemiology; D017954:Africa South of the Sahara / Q000453:epidemiology; D019380:Anti-HIV Agents / Q000191:economics / Q000627:therapeutic use*; D023241:Antiretroviral Therapy, Highly Active / Q000191:economics; D003140:Communicable Disease Control / Q000458:organization & administration; D004352:Drug Resistance, Microbial; D015658:HIV Infections / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D010349:Patient Compliance; D014376:Tuberculosis / Q000517:prevention & control
chemical_list: D019380:Anti-HIV Agents