Solid-phase analysis method for (S)-[18F]fluorocarazolol and its metabolites.
(S)-[18F]Fluorocarazolol is a radiopharmaceutical developed to quantitatively assess beta-adrenergic receptors in vivo via positron emission tomography imaging. Since radioactive metabolites of (S)-[18F]fluorocarazolol rapidly appear in the plasma, methods for conveniently and reliably evaluating plasma for (S)-[18F]fluorocarazolol content are required. Here we present methods and validation of an approach using commercial extraction cartridges that is faster and more convenient than an approach using internal-surface reverse-phase chromatography but yields comparable results.
Muzic
R F
RF
Case Western Reserve University, Cleveland, OH 44106, USA. rfm2@po.cwru.edu
Landmeier
B
B
Zhang
Z
Z
Zheng
L
L
Berridge
M S
MS
D000319:Adrenergic beta-Antagonists / Q000097:blood*; D002227:Carbazoles / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D011412:Propanolamines / Q000097:blood*; D019275:Radiopharmaceuticals / Q000097:blood*; D012680:Sensitivity and Specificity
D000319:Adrenergic beta-Antagonists; D002227:Carbazoles; D011412:Propanolamines; D019275:Radiopharmaceuticals; C089702:fluorocarazolol