title: Botulinum toxin type A and dynamic equinus in children with cerebral palsy: new indication. Better than repeat casts.
abstract: (1) Botox degrees , a product based on type A botulinum toxin, has received a new licensed indication in the local treatment of dynamic equinus in children with spasticity due to cerebral palsy.  (2) Three placebo-controlled trials show that intramuscular injections of type A botulinum toxin reduce spastic equinus and substantially improve walking for at least 3 months.  Two small trials, each involving 20 children, show no difference in effects between type A botulinum toxin and successive stretching casts.  (3) In this setting the risk of adverse effects is smaller with type A botulinum toxin than with stretching casts.  (4) Treatment with type A botulinum toxin is costly.
mesh_terms: D000293:Adolescent; D019274:Botulinum Toxins, Type A / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D002370:Casts, Surgical / Q000009:adverse effects; D002547:Cerebral Palsy / Q000150:complications / Q000188:drug therapy* / Q000191:economics; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004863:Equinus Deformity / Q000188:drug therapy* / Q000191:economics / Q000209:etiology; D006801:Humans; D009465:Neuromuscular Agents / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D009465:Neuromuscular Agents; D019274:Botulinum Toxins, Type A