title: Ameloblastic fibrosarcoma: report of a case. Immunohistochemical study and review of the literature.
abstract: Ameloblastic fibrosarcoma is a rare malignant odontogenic tumour characterized by a benign epithelial component within a malignant fibrous stroma. Its behaviour is relatively benign, with absence of metastatic disease, and the prognosis is reported to be good. It is a paradoxical neoplasm with "sarcomatous" morphological and immunohistochemical patterns but with a favourable clinical course. We report a new case of this tumour in a mandibular ramus of a 31-years-old male patient, that was surgically excised and treated with adjuvant chemotherapy and radiotherapy. Five years later the patient is free of disease. The growth potential of ameloblastic fibrosarcoma is evaluated and compared with a related lesion, the ameloblastic fibroma. The sarcomatous mesenchymal component of ameloblastic fibrosarcoma is positive to Ki67, PCNA and p53, in front of the negativity of ameloblastic fibroma.
authors.affiliation: Departamento de Anatomia Patológica, Hospital Universitario Vall d'Hebron, Barcelona, España. phuguet@cs.vhebron.es
authors.forename: P
authors.initials: P
authors.lastname: Huguet
authors.forename: J
authors.initials: J
authors.lastname: Castellví
authors.forename: M
authors.initials: M
authors.lastname: Avila
authors.forename: M
authors.initials: M
authors.lastname: Alejo
authors.forename: F
authors.initials: F
authors.lastname: Autonell
authors.forename: C
authors.initials: C
authors.lastname: Basas
authors.forename: M S
authors.initials: MS
authors.lastname: Bescos
mesh_terms: D000328:Adult; D017024:Chemotherapy, Adjuvant; D004847:Epithelial Cells / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D019394:Ki-67 Antigen / Q000032:analysis; D008297:Male; D008339:Mandibular Neoplasms / Q000473:pathology* / Q000601:surgery; D008648:Mesoderm / Q000473:pathology; D009808:Odontogenic Tumors / Q000473:pathology* / Q000601:surgery; D011379:Prognosis; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D018714:Radiotherapy, Adjuvant; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D019394:Ki-67 Antigen; D018809:Proliferating Cell Nuclear Antigen; D016159:Tumor Suppressor Protein p53