Evolution of scoliosis in six children treated with growth hormone.
During a period of 6 years to 11 years, the authors have been following six girls with scoliosis and treated with growth hormone (GH) for a growth insufficiency. The treatment with GH started after the discovery of the scoliosis for five patients. Three curve progressions have been observed, but always in the puberty period. Only one progression was noticed at the beginning of the GH treatment, but it was relieved with bracing. The results of this study do not permit one to conclude that a relation exists between GH treatment and scoliotic progression. This treatment is nevertheless not devoid of side effects, and a rigorous supervision is necessary.
Vidil
A
A
Pediatric Orthopaedic Department, Medicine Faculty Paris-Necker, University Paris V René-Descartes, Hĵpital des Enfants Malades, France.
Journeau
P
P
Soulie
A
A
Padovani
J P
JP
Pouliquen
J C
JC
D000293:Adolescent; D000365:Age Determination by Skeleton; D001827:Body Height / Q000187:drug effects; D001915:Braces; D002648:Child; D018450:Disease Progression; D016903:Drug Monitoring; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000150:complications* / Q000188:drug therapy*; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D011627:Puberty; D012600:Scoliosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology* / Q000628:therapy; D013997:Time Factors
D013006:Growth Hormone