Androgens: biphasic dose responses.
Testosterone was reported to affect a variety of reproductive endpoints. More notable were the effects of dihydrotestosterone on cell proliferation in the prostate cancer cell model LNCaP and Sertoli cell function. Testosterone production was also biphasically affected by prolactin that was administered to adult testicular cells in vitro.
Calabrese
E J
EJ
Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu
D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D019902:Chondrocytes / Q000187:drug effects / Q000502:physiology; D013196:Dihydrotestosterone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D011388:Prolactin / Q000494:pharmacology; D011471:Prostatic Neoplasms / Q000503:physiopathology; D012708:Sertoli Cells / Q000187:drug effects / Q000502:physiology; D013737:Testis / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D013739:Testosterone / Q000096:biosynthesis / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000728:Androgens; D013196:Dihydrotestosterone; D013739:Testosterone; D011388:Prolactin