OLIG2 as a specific marker of oligodendroglial tumour cells.
OLIG2 is a recently identified transcription factor involved in the specification of cells in the oligodendroglial lineage. We investigated the expression of OLIG2 by in-situ hybridisation in 21 brain tumours: nine grade II and III oligodendrogliomas, three grade II oligoastrocytomas, and nine non-oligodendroglial tumours (four grade IV astrocytomas, two meningiomas, a dysembryoplastic neuroepithelial tumour, and two metastases). OLIG2-positive cells corresponding to neoplastic oligodendrocytes were present in all oligodendrogliomas and oligoastrocytomas. By contrast, OLIG2 expression was not detected in the non-oligodendroglial tumours. Thus, oligodendroglioma probably arise from oligodendrocyte precursor cells. OLIG2 should prove a useful marker for the diagnosis of oligodendroglial tumours.
Marie
Y
Y
Sanson
M
M
Mokhtari
K
K
Leuraud
P
P
Kujas
M
M
Delattre
J Y
JY
Poirier
J
J
Zalc
B
B
Hoang-Xuan
K
K
D001254:Astrocytoma / Q000145:classification / Q000175:diagnosis* / Q000235:genetics; D051792:Basic Helix-Loop-Helix Proteins; D014408:Biomarkers, Tumor / Q000302:isolation & purification*; D001932:Brain Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D017403:In Situ Hybridization; D009419:Nerve Tissue Proteins / Q000302:isolation & purification*; D000076104:Oligodendrocyte Transcription Factor 2; D009837:Oligodendroglioma / Q000145:classification / Q000175:diagnosis* / Q000235:genetics*
D051792:Basic Helix-Loop-Helix Proteins; D014408:Biomarkers, Tumor; D009419:Nerve Tissue Proteins; D000076104:Oligodendrocyte Transcription Factor 2; C405708:OLIG2 protein, human