Epidemiology of progressive supranuclear palsy. ESGAP Consortium. European Study Group on Atypical Parkinsonisms.
Progressive supranuclear palsy (PSP) is a rare form of parkinsonism. The incidence rates are about 0.3-1.1 cases per 100,000 persons. The only two case-control studies performed up to now show conflictual results as regards education and residence in rural areas. Recently, a cluster of PSP and atypical parkinsonism has been observed in French Antilles. The hypothesis is that a consumption of both tropical fruit and herbal tea may be associated with PSP onset. Some PSP families with a probably autosomal dominant transmission have been described. A high frequency of a tau haplotype (H1/H1) associated with PSP is reported by some authors. The significance of this association is still not clear. We have performed a case-control study on 58 PSP cases, 116 hospital controls and 58 population controls.
Vanacore
N
N
Department of Neurological Sciences, La Sapienza University, Rome, Italy.
Bonifati
V
V
Colosimo
C
C
Fabbrini
G
G
De Michele
G
G
Marconi
R
R
Nicholl
D
D
Locuratolo
N
N
Romano
S
S
Talarico
G
G
Stocchi
F
F
Bonuccelli
U
U
Lamberti
P
P
Vieregge
P
P
Meco
G
G
D017668:Age of Onset; D001628:Beverages / Q000009:adverse effects; D004781:Environmental Exposure; D005260:Female; D005820:Genetic Testing; D019430:Guadeloupe / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D009154:Mutation / Q000235:genetics; D009784:Occupational Diseases / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D013494:Supranuclear Palsy, Progressive / Q000453:epidemiology* / Q000503:physiopathology; D016875:tau Proteins / Q000235:genetics
D016875:tau Proteins