Automatic discriminative sensitivity inside temporal window of sensory memory as a function of time.
Neural representation of preceding sound-patterns stored in the human brain, as reflected by mismatch negativity (MMN) related to the automatic discriminative process, is restricted to a duration of 160-170 ms due to the short form of auditory sensory memory termed the temporal window of integration (TWI). To examine the temporal uniformity of deviation-sensitivity inside TWI of sensory memory, magnetic MMN (MMNm) responses were measured with a dual 37-channel magnetometer for complex sounds of 170 ms duration containing an omitted (silent) segment. Frequent standard stimuli (probability of 80%) consisted of five tone segments. Deviant stimuli were different from standard stimuli in that one of four segments was occasionally (probability of 5%) omitted and replaced by a silent segment. The stimulus duration of 170 ms was intended to correspond to the postulated duration of TWI. When the silent segment occurred later in deviant stimulus, the MMNm peak amplitude was attenuated and MMNm peak latency, measured from the onset of each silent segment, was delayed. Thus, automatic deviation-detection sensitivity declines nonlinearly toward the end of TWI in auditory sensory memory. In the second experiment, two types of deviant stimuli, which differed from each other only in the period after the occurrence of the silent segment, elicited MMNm with the same peak latency but with a different peak amplitude. Thus, mismatch process is triggered at the moment of change but still lasts after the detection of deviation. In other words, both standard and deviant stimuli are treated as a unitary event within a TWI.
Yabe
H
H
Department of Neuropsychiatry, Hirosaki University School of Medicine, Hirosaki 036-8562, Japan. yabe@cc.hirosaki-u.ac.jp
Koyama
S
S
Kakigi
R
R
Gunji
A
A
Tervaniemi
M
M
Sato
Y
Y
Kaneko
S
S
D000161:Acoustic Stimulation; D000328:Adult; D004192:Discrimination, Psychological / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000502:physiology; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006309:Hearing / Q000502:physiology*; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008568:Memory / Q000502:physiology*; D013997:Time Factors