title: [A study of association between atherothrombotic brain infarction and HLA-DQA1 peptide binding motifs].
abstract: OBJECTIVE
  To analyze the hereditary susceptibility for HLA-DQA1 alleles according to trait of multiple genes leading to disease in atherothrombotic brain infarction (ABI).
  
  
  METHODS
  HLA-DQA1 alleles in ABI patients (n=81) and healthy controls (n=99) were detected by PCR-SSP techniques.
  
  
  RESULTS
  (1)The frequency of HLA-DQA1*0301 was significantly higher in ABI patients. (2)The frequency of HLA-DQA1*0301 was significantly higher in patients with family history of essential hypertension (EH). (3)The frequency of HLA-DQA1*0103 was significantly lower in ABI patients.
  
  
  CONCLUSIONS
  HLA-DQA1*0301 allele might be a correlative gene with hereditary susceptibility of ABI and HLA-DQA1*0301 allele might be a correlative gene in ABI patients with the family history of essential hypertension, whereas HLA-DQA1*0103 allele might be a protective gene in the patients with ABI.
authors.affiliation: Department of Medicine, Hu Guo Si Hospital of Traditional Chinese Medicine Affliated to Beijing Traditional Chinese Medicine and Materia Medical University,Beijing 100035 P.R.China.
authors.forename: N
authors.initials: N
authors.lastname: Shen
authors.forename: Z
authors.initials: Z
authors.lastname: Yan
authors.forename: P
authors.initials: P
authors.lastname: He
authors.forename: Y
authors.initials: Y
authors.lastname: Jin
authors.forename: S
authors.initials: S
authors.lastname: Wang
mesh_terms: D000368:Aged; D044466:Asian People; D020520:Brain Infarction / Q000235:genetics*; D004198:Disease Susceptibility; D020022:Genetic Predisposition to Disease; D005838:Genotype; D006683:HLA-DQ Antigens / Q000737:chemistry / Q000235:genetics*; D059848:HLA-DQ alpha-Chains; D006801:Humans; D008875:Middle Aged; D011110:Polymorphism, Genetic; D020521:Stroke / Q000235:genetics
chemical_list: D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen