title: Failure of the ubiquitin-proteasome system in Parkinson's disease.
authors.affiliation: Neuroregeneration Laboratory, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. kevin.mcnaught@mclean.harvard.edu
authors.forename: K S
authors.initials: KS
authors.lastname: McNaught
authors.forename: C W
authors.initials: CW
authors.lastname: Olanow
authors.forename: B
authors.initials: B
authors.lastname: Halliwell
authors.forename: O
authors.initials: O
authors.lastname: Isacson
authors.forename: P
authors.initials: P
authors.lastname: Jenner
mesh_terms: D000818:Animals; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016631:Lewy Bodies / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D013378:Substantia Nigra / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D014452:Ubiquitins / Q000235:genetics / Q000378:metabolism*
chemical_list: D009097:Multienzyme Complexes; D009419:Nerve Tissue Proteins; D014452:Ubiquitins; D010447:Peptide Hydrolases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex