title: Dosimetry close to an 192Ir HDR source using N-vinylpyrrolidone based polymer gels and magnetic resonance imaging.
abstract: In this work, the utilization of polymer gel-MRI dosimetry for measurements at distances relevant to clinical brachytherapy and intravascular applications [i.e., in the mm range, where steep three-dimensional (3-D) dose gradients exist] is investigated using N-vinylpyrrolidone-based gels. Transverse axis radial dose distributions, dose distributions parallel to the source axis, and 2-D dose distributions around the commonly used microSelectron 192Ir HDR source are measured for single source dwell position irradiations. Experimental results are found in good agreement with verified Monte Carlo calculations, even for distances less than 3 mm from the source. The effect of various MRI parameters, such as slice thickness, slice mispositioning, and in-plane resolution, on the accuracy of the method is also investigated. Possible limitations of the method are discussed, and its' overall potential in brachytherapy dosimetry is evaluated. Experimental 2-D dose distributions for an intravascular application following the Paris irradiation protocol are compared to corresponding commercial treatment planning system calculations. Results suggest that polymer gel-MRI dosimetry is capable of experimentally verifying dose distributions in relevant clinical intravascular applications.
authors.affiliation: Department of Physics, University of Athens, Greece. ppapagi@cc.uoa.gr
authors.forename: P
authors.initials: P
authors.lastname: Papagiannis
authors.forename: E
authors.initials: E
authors.lastname: Pappas
authors.forename: P
authors.initials: P
authors.lastname: Kipouros
authors.forename: A
authors.initials: A
authors.lastname: Angelopoulos
authors.forename: L
authors.initials: L
authors.lastname: Sakelliou
authors.forename: P
authors.initials: P
authors.lastname: Baras
authors.forename: P
authors.initials: P
authors.lastname: Karaiskos
authors.forename: I
authors.initials: I
authors.lastname: Seimenis
authors.forename: P
authors.initials: P
authors.lastname: Sandilos
authors.forename: D
authors.initials: D
authors.lastname: Baltas
mesh_terms: D016880:Anisotropy; D001672:Biocompatible Materials; D001918:Brachytherapy / Q000379:methods*; D002138:Calibration; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D007496:Iridium Radioisotopes / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009010:Monte Carlo Method; D011108:Polymers; D011760:Pyrrolidinones; D011874:Radiometry / Q000379:methods*
chemical_list: D001672:Biocompatible Materials; D007496:Iridium Radioisotopes; D011108:Polymers; D011760:Pyrrolidinones; C042670:N-vinyl-2-pyrrolidinone