title: [Synthesis and antibacterial activity of tricycic fluoroquinolones].
abstract: Twelve new analogues of new tricyclic rufloxacin were prepared and their MIC were evaluated against thirteen kinds of bacteria. As a result of these studies: the polarity of C10-side chain was found to exert greater positive effect on G- than on G+ bacteria.
authors.affiliation: Medicinal and Chemical Institute of China Pharmaceutical University, Nanjing 210009.
authors.forename: W N
authors.initials: WN
authors.lastname: Xiong
authors.forename: E H
authors.initials: EH
authors.lastname: Wang
mesh_terms: D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D024841:Fluoroquinolones; D015363:Quinolones / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; C060328:rufloxacin