title: In vitro activity of sertaconazole, fluconazole, ketoconazole, fenticonazole, clotrimazole and itraconazole against pathogenic vaginal yeast isolates.
abstract: The in vitro activity of sertaconazole was compared with those of the most commonly used vaginal antimycotic agents--fluconazole, ketoconazole, fenticonazole, clotrimazole and itraconazole--against 94 strains of clinical isolates of Candida spp. using a macrodilution method in Casitone agar medium. The sertaconazole concentration (microgram/ml), at which 90% of the strains were inhibited, was 0.06 for C. albicans, 0.25 for C. glabrata and C. parapsilosis, 1 for C. krusei and 2 for C. tropicalis. These values show that sertaconazole is one of the most active products against yeasts causing vulvovaginal candidiasis, its activity against C. glabrata being particularly relevant.
authors.affiliation: Department of Microbiology, Centro de Investigación Grupo Ferrer, Barcelona, Spain. palacin-research@ferrergrupo.com
authors.forename: C
authors.initials: C
authors.lastname: Palacín
authors.forename: C
authors.initials: C
authors.lastname: Tarragó
authors.forename: J
authors.initials: J
authors.lastname: Agut
authors.forename: A
authors.initials: A
authors.lastname: Guglietta
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D013876:Thiophenes; C061131:sertaconazole