Does aging adversely affect muscle mitochondrial function?
Muscle oxidative function appears to decline with aging, and evidence suggests that this is related to reduced synthesis of mitochondrial and other muscle proteins. Causes for these events may include mtDNA damage or reduced mtDNA copy numbers, reduced oxidative enzyme activities and ATP production, and increased proton leak.
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K R
KR
Endocrinology Research Unit, Mayo Clinic and Foundation, Rochester, Minnesota, USA.
Nair
K S
KS
D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology* / Q000502:physiology*; D000818:Animals; D019069:Cell Respiration / Q000502:physiology; D004272:DNA, Mitochondrial / Q000502:physiology; D015444:Exercise / Q000502:physiology; D006801:Humans; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000235:genetics / Q000378:metabolism*; D024101:Mitochondrial Proteins / Q000096:biosynthesis; D018482:Muscle, Skeletal / Q000166:cytology* / Q000502:physiology*; D016296:Mutagenesis / Q000235:genetics / Q000502:physiology; D018384:Oxidative Stress / Q000235:genetics / Q000502:physiology; D010088:Oxidoreductases / Q000378:metabolism; D012313:RNA / Q000032:analysis; D000077278:RNA, Mitochondrial; D051381:Rats
D004272:DNA, Mitochondrial; D024101:Mitochondrial Proteins; D000077278:RNA, Mitochondrial; D012313:RNA; D000255:Adenosine Triphosphate; D010088:Oxidoreductases