[Yishen huanshuai recipe retard progression of chronic renal failure].
OBJECTIVE
To investigate the effect of Yishen Huanshuai recipe (YSHSR) on the progression of chronic renal failure (CRF).


METHODS
Forty-six patients with CRF were divided into two groups: group A (self-controlled group, n = 18), whose treatment was subdivided into two stages. During the first stage, the patients treated with low protein diet and controlling blood pressure, while in the second stage, YSHSR was given. Group B(n = 28), whose treatment plan was similar with that of group A in second stage. The rate of progression of CRF was estimated by slope of the creatinine reciporcal (dl/mg) with time (month).


RESULTS
Mean slope of the creatinine reciprocal with time from the group A during the first stage was -0.0104 +/- 0.0021, while during the second stage, it was -0.0034 +/- 0.0018. There was significant difference between them (P < 0.05). Mean slope from the group B was -0.0047 +/- 0.0020. There was also significant difference between that from the group B and that from the group A during the first stage (P < 0.05).


CONCLUSIONS
Low protein and controlling blood pressure plus YSHSR therapy could markedly retard the rate of progression of CRF.
Yin
D
D
Guang'anmen Hospital, China Academy of TCM 100053.
Dai
X
X
Rao
X
X
D000328:Adult; D003404:Creatinine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D004365:Drugs, Chinese Herbal; D003404:Creatinine