title: Autoimmune disease: why and where it occurs.
abstract: Autoimmune disease is controlled by genetic and environmental factors. Both of these affect susceptibility to autoimmunity at three levels: the overall reactivity of the immune system, the specific antigen and its presentation, and the target issue.
authors.affiliation: Howard Hughes Medical Institute, University of Colorado Health Sciences Center, Denver, Colorado, USA. marrackp@njc.org
authors.forename: P
authors.initials: P
authors.lastname: Marrack
authors.forename: J
authors.initials: J
authors.lastname: Kappler
authors.forename: B L
authors.initials: BL
authors.lastname: Kotzin
mesh_terms: D000941:Antigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D002874:Chromosome Mapping; D003429:Cross Reactions; D006801:Humans; D008954:Models, Biological
chemical_list: D000941:Antigens