Sox8 gene expression identifies immature glial cells in developing cerebellum and cerebellar tumours.
Sox8 is a member of the E subgroup of Sox genes, the other members of which are Sox9 and Sox10, both of which are implicated in specific human disorders. Recently, Sox8 homologues have been cloned in chick, mouse and human and have been shown to be strongly expressed in the embryonic and adult brain. Nevertheless, the cell types that express Sox8 have not been determined. We show here that Sox8 is expressed in immature glia in the developing cerebellum. Sox8 is also expressed in scattered cells in the cerebellar tumour, medulloblastoma. This gene therefore provides an early glial marker that may provide more detailed insight into the cellular makeup and consequent behaviour of medulloblastomas.
Cheng
Y C
YC
Nottingham Children's Brain Tumour Research Centre, Institute of Genetics, University of Nottingham, Queen's Medical Centre, Nottingham NG7 2UH, UK.
Lee
C J
CJ
Badge
R M
RM
Orme
A T
AT
Scotting
P J
PJ
D000818:Animals; D015415:Biomarkers; D001932:Brain Neoplasms / Q000378:metabolism / Q000473:pathology; D002528:Cerebellar Neoplasms / Q000378:metabolism* / Q000473:pathology; D002531:Cerebellum / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D002642:Chick Embryo; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000235:genetics; D020869:Gene Expression Profiling; D018507:Gene Expression Regulation, Developmental; D015723:Gene Library; D005910:Glioma / Q000378:metabolism / Q000473:pathology; D006801:Humans; D017403:In Situ Hybridization; D008527:Medulloblastoma / Q000378:metabolism* / Q000473:pathology; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D009457:Neuroglia / Q000378:metabolism*; D055757:SOXE Transcription Factors; D014157:Transcription Factors / Q000096:biosynthesis* / Q000235:genetics; D014158:Transcription, Genetic
D015415:Biomarkers; D004268:DNA-Binding Proteins; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; C406240:SOX8 protein, human; D055757:SOXE Transcription Factors; D014157:Transcription Factors