[Effect of anti-opioid peptide sera on the enhancement of electroacupuncture analgesia induced by neurotensin in PAG of rats].
With the use of potassium iontophoresis induced tail-flick for measuring the pain threshold, the effects of injecting neurotensin (NT), naloxone (NX), anti-metenkephalin serum (AMEKS), anti-beta-endorphin serum (AEPS) and anti-dynorphin A1-13 serum (ADYNS) into periaqueductal gray (PAG) on electroacupuncture (EA) analgesia in rats were investigated. NT administration enhanced EA analgesia remarkably. Pre-injection of NX, AMEKS and AEPS into PAG could significantly attenuate the enhancement of EA analgesia induced by NT, but not by administration of ADYNS. The results indicate that NT in PAG is responsible for the enhancement of EA analgesia. The effect of NT may be partly mediated by met-enkephalin and beta-endorphin.
Bai
B
B
Laboratory of Neurophysiology, Jining Medical College, Jining 272113.
Wang
H
H
Liu
W Y
WY
Song
C Y
CY
D015667:Acupuncture Analgesia; D000818:Animals; D015671:Electroacupuncture; D004744:Enkephalin, Methionine / Q000276:immunology; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D009496:Neurotensin / Q000502:physiology*; D018847:Opioid Peptides / Q000276:immunology*; D010487:Periaqueductal Gray / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D001615:beta-Endorphin / Q000276:immunology
D007106:Immune Sera; D018847:Opioid Peptides; D009496:Neurotensin; D004744:Enkephalin, Methionine; D001615:beta-Endorphin