title: Protection of pigs with cysticercosis from further infections after treatment with oxfendazole.
abstract: Cysticercosis, the infection by the larvae of Taenia solium, is a major cause of acquired epilepsy in the world; it also causes significant economic loss because of contaminated pork. This disease is endemic in most developing countries and no control strategy has yet been proven efficient and sustainable. To further evaluate the full potential of single-dose oxfendazole treatment for pigs as a control measure, 20 pigs with cysticercosis were treated with oxfendazole and later matched with 41 naive pigs and exposed to a natural challenge in a hyperendemic area. New infections were found by serologic testing in 15 of the 32 controls (47%), and by the presence of cysts at necropsy in 12 of them (37%). Only minute residual scars were detected in the carcasses of oxfendazole-treated pigs. Pigs with cysticercosis, once treated with oxfendazole, are protected from new infections for at least three months.
authors.affiliation: School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Salamanca de Monterrico, Lima, Peru.
authors.forename: A E
authors.initials: AE
authors.lastname: Gonzalez
authors.forename: C
authors.initials: C
authors.lastname: Gavidia
authors.forename: N
authors.initials: N
authors.lastname: Falcon
authors.forename: T
authors.initials: T
authors.lastname: Bernal
authors.forename: M
authors.initials: M
authors.lastname: Verastegui
authors.forename: H H
authors.initials: HH
authors.lastname: Garcia
authors.forename: R H
authors.initials: RH
authors.lastname: Gilman
authors.forename: V C
authors.initials: VC
authors.lastname: Tsang
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D000909:Antibodies, Helminth / Q000097:blood; D001562:Benzimidazoles / Q000627:therapeutic use*; D001921:Brain / Q000469:parasitology; D003551:Cysticercosis / Q000453:epidemiology / Q000517:prevention & control / Q000662:veterinary*; D015151:Immunoblotting / Q000662:veterinary; D011446:Prospective Studies; D016036:Seroepidemiologic Studies; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy / Q000469:parasitology / Q000517:prevention & control*; D013621:Taenia / Q000187:drug effects*
chemical_list: D000871:Anthelmintics; D000909:Antibodies, Helminth; D001562:Benzimidazoles; C011030:oxfendazole