Structural changes in the kidney induced by coarctation hypertension.
We investigated structural alterations in renal tissue identifying the morphological and histological changes in the non-ischemic kidney (NIK) and their potential significance in aortic coarctation-hypertensive rats (HR). HR's mean arterial pressure (MAP) was higher compared with sham operated rats (SR). An oral 10 mg/kg/day losartan (LOS) dose diminished but not reverted MAP. Hypertrophy was noted in HR NIK's with significant weight increase (p<0.01). The ratio IK/NIK in HR's decreased 22% (p<0.01). LOS proved to cause no ischemic kidney (IK) modification nor did it revert NIK hypertrophy. NIK in HR's presented glomerulosclerosis, mesangial proliferation and arteriolar thickening reverted by LOS. The stereological study of afferent NIK arterioles showed hypertrophy and an increase in the wall/lumen ratio without lumen modification. LOS diminished wall thickness. LOS-induced decrease of NIK alterations might result from arteriosclerosis regression, the media/lumen ratio. glomerulosclerosis and mesangial proliferation dependent on angiotensin 11.
De Bruno
M P
MP
Department of Physiology, INSIBIO-National University of Tucumán, Argentina. peralmaria@hotmail.com
Turoni CMJ
Marañón
R O
RO
Reynoso
H A
HA
Coviello
A
A
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001017:Aortic Coarctation / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D001835:Body Weight / Q000502:physiology; D004195:Disease Models, Animal; D006339:Heart Rate / Q000187:drug effects; D006654:Histology, Comparative; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*; D007668:Kidney / Q000033:anatomy & histology* / Q000737:chemistry* / Q000187:drug effects; D019808:Losartan / Q000627:therapeutic use; D008297:Male; D009929:Organ Size / Q000502:physiology; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D012077:Renal Artery / Q000503:physiopathology
D000959:Antihypertensive Agents; D019808:Losartan