[Esterase-metabolized remifentanil hydrochloride opioid (Ultiva-TM), a new step towards the solution of the problem of regulation of analgetic components of general anesthesia].
Hemodynamics, gas exchange, velocity of psychomotor recovery, pain intensity during and after laparoscopic cholecystectomy were studied in patients anesthetized (total intravenous anesthesia) by two methods: 1) remifentanyl and propofol, forced ventilation of the lungs, and myoplegia (n = 21, ASA I-III) and 2) fentanyl and propofol, forced ventilation of the lungs, and myoplegia (n = 18, ASA I-III). Total intravenous anesthesia based on remifentanyl was characterized by stability of hemodynamic and gas exchange parameters at all stages of the intervention. This method ensured a smooth and rapid course of resuscitation, characterized by absence of signs of central respiration depression, predictable normalization of psychomotor status, and low incidence of factors provoking postoperative nausea and vomiting, on condition of their prevention. Further studies of remifentanyl are needed in interventions of different degree of traumatism and within the framework of different protocols of postoperative analgesia.
Buniatian
A A
AA
Mizikov
V M
VM
Lovtsevich
N V
NV
Stamov
V I
VI
Flerov
E V
EV
D000328:Adult; D000701:Analgesics, Opioid / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D017081:Cholecystectomy, Laparoscopic; D003627:Data Interpretation, Statistical; D004950:Esterases / Q000378:metabolism; D005283:Fentanyl / Q000008:administration & dosage / Q000494:pharmacology; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy; D010880:Piperidines / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology; D011659:Pulmonary Gas Exchange / Q000187:drug effects; D000077208:Remifentanil; D012121:Respiration, Artificial; D013997:Time Factors
D000701:Analgesics, Opioid; D018686:Anesthetics, Intravenous; D006993:Hypnotics and Sedatives; D010880:Piperidines; D004950:Esterases; D000077208:Remifentanil; D005283:Fentanyl; D015742:Propofol