title: Amlodipine-induced gingival overgrowth: periodontal responses to stopping and restarting the drug.
abstract: A case history of a woman with gingival overgrowth (GO) induced by amlodipine is presented. A 49-year-old Japanese woman, who was taking amlodipine, had gingival overgrowth and swelling on examination. No specific periodontal treatment was provided to the patient for the GO; however, the amlodipine was replaced with an ACE inhibitor after consultation with her medical practitioner. Within two months, the suspension of amlodipine resulted in a significant improvement in her periodontal condition. Failure to control the hypertension caused the physician to re-prescribe amlodipine. After three months, the gingival overgrowth returned; however, its severity was less when compared with the original periodontal condition, due to reduction in drug dose and periodontal therapy. This experience suggests that temporary suspension of a drug which can induce GO can improve the periodontal condition without the aid of surgical treatment.
authors.affiliation: Division of Special Care Dentistry, Osaka University Faculty of Dentistry, 1-8 Yamadaoka, Suita-Osaka 565-0871, Japan. morisaki@dent.osaka-u.ac.jp
authors.forename: I
authors.initials: I
authors.lastname: Morisaki
authors.forename: S
authors.initials: S
authors.lastname: Dol
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: A
authors.initials: A
authors.lastname: Amano
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: J
authors.initials: J
authors.lastname: Mihara
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000627:therapeutic use; D017311:Amlodipine / Q000008:administration & dosage / Q000009:adverse effects*; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D005884:Gingival Hemorrhage / Q000139:chemically induced / Q000517:prevention & control; D019214:Gingival Overgrowth / Q000139:chemically induced* / Q000517:prevention & control; D005888:Gingival Pocket / Q000139:chemically induced / Q000517:prevention & control; D006801:Humans; D008875:Middle Aged; D012008:Recurrence
chemical_list: D000319:Adrenergic beta-Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D017311:Amlodipine