title: Anticonvulsant and sedative effects of some 5-substituted bromopyrazolinic spirobarbiturates.
abstract: We studied in mice the neuropharmacological effect of some 5-substituted bromopyrazolinic spirobarbiturates. LD50 and CL50 values were estimated for all the investigated compounds. The effect on potentiation of sodium pentobarbital activity and on generalised tonic-clonic seizures produced by PTZ on mice was studied. All the compounds had the same pharmacological profile, they extended sleeping-time induced by sodium pentobarbital and showed protection against PTZ-induced convulsions, decreasing the death rate.
authors.affiliation: Pharmaco-Biological Department, School of Pharmacy, University of Messina, Italy. emgalati@unime.it
authors.forename: E M
authors.initials: EM
authors.lastname: Galati
authors.forename: M T
authors.initials: MT
authors.lastname: Monforte
authors.forename: N
authors.initials: N
authors.lastname: Miceli
authors.forename: E
authors.initials: E
authors.lastname: Raneri
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D003292:Convulsants / Q000494:pharmacology; D004357:Drug Synergism; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D010424:Pentobarbital / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D013237:Stereoisomerism
chemical_list: D000927:Anticonvulsants; D003292:Convulsants; D006993:Hypnotics and Sedatives; D011720:Pyrazoles; D010424:Pentobarbital; D010433:Pentylenetetrazole