[Effect of different immunomodulators on macrophage function in rats with scald injury].
OBJECTIVE
To explore effect of different immunomodulators on macrophage (M phi) functions in rats with scald injury.


METHODS
The M phi functions in various groups of rats with scald on the 5th and 10th day after scald were respectively determined with methods of McAb APAAP, agar bacteriolytic plate and MTT colorimetry.


RESULTS
The results showed that: 1. after scald, presenting rate of Ia antigen, ability of antigen presentation, phagocytic power to candida albicans and lysozyme ability of M phi were significantly decreased, the capacity of M phi secreting TNF was markedly increased compared with those of the normal group, and the differences were significant (P < 0.01); 2. after the therapy with immunodulators, the above functions of M phi in rats with scald improved markedly. As compared with those of the control group, differences were significant (P < 0.01).


CONCLUSIONS
The specific immune RNA, which is administered by intraperitoneal injection early after scald, can markedly improve immune functions of rats with scald.
Zhuo
A
A
465th Hospital of People's Liberation Army, Jilin, 132011.
Chen
A
A
Shen
F
F
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D002056:Burns / Q000276:immunology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D005260:Female; D016233:Immunotherapy, Active; D008264:Macrophages / Q000276:immunology*; D008297:Male; D011134:Polysaccharides / Q000302:isolation & purification / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D011134:Polysaccharides