title: Kashin-Beck disease and iodine deficiency in Tibet.
abstract: We evaluated iodine and selenium status in 575 children between 5 and 15 years with Kashin-Beck disease from endemic and non-endemic areas. Of these 267 (46%) children had goiter. The proportion of subjects with goiter was higher in the villages with Kashin-Beck disease than in the control village. In the villages with Kashin-Beck disease, 105 (23%) of the subjects had a serum thyrotropin greater than 10 mU/l as compared with 3 (4%) in the control village. The percentages of low serum thyroxine values and low serum tri-iodothyronine were greater in the villages where Kashin-Beck disease was endemic than in the control village. The percentages of low urinary iodine concentration were significantly greater in the subjects with Kashin-Beck disease. The results suggest that in areas where severe selenium deficiency is endemic, iodine deficiency is a risk factor for Kashin-Beck disease.
authors.affiliation: Department of Nuclear Medicine, Hĵpital Erasme, Université Libre de Bruxelles, Brussels, Belgium. rmorenor@ulb.ac.be
authors.forename: R
authors.initials: R
authors.lastname: Moreno-Reyes
authors.forename: C
authors.initials: C
authors.lastname: Suetens
authors.forename: F
authors.initials: F
authors.lastname: Mathieu
authors.forename: F
authors.initials: F
authors.lastname: Begaux
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.forename: T
authors.initials: T
authors.lastname: Rivera
authors.forename: M
authors.initials: M
authors.lastname: Boelaert
authors.forename: J
authors.initials: J
authors.lastname: Nève
authors.forename: N
authors.initials: N
authors.lastname: Perlmutter
authors.forename: J
authors.initials: J
authors.lastname: Vanderpas
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006801:Humans; D007455:Iodine / Q000172:deficiency* / Q000652:urine; D008297:Male; D010003:Osteoarthritis / Q000097:blood / Q000453:epidemiology*; D012307:Risk Factors; D012643:Selenium / Q000172:deficiency*; D018609:Tibet / Q000453:epidemiology
chemical_list: D007455:Iodine; D012643:Selenium