A randomized, blinded comparison of chloral hydrate and midazolam sedation in children undergoing echocardiography.
The objective of this prospective, randomized, and blinded study was to compare the use of chloral hydrate versus oral midazolam sedation in children undergoing echocardiography. No adverse effects (nausea, vomiting, paradoxical agitation, or significant deviations from baseline vital signs) were noted with either medication. No differences were noted in onset of sedation between the 2 groups, however, the time to complete recovery was significantly shorter with midazolam than with chloral hydrate. The children in the chloral hydrate group had a significantly deeper level of sedation and were more likely to receive a more nearly comprehensive echocardiographic evalation.
Wheeler
D S
DS
Division of Critical Care Medicine, Children's Hospital Medical Center, Cincinnati, OH, USA.
Jensen
R A
RA
Poss
W B
WB
D000284:Administration, Oral; D002675:Child, Preschool; D002697:Chloral Hydrate / Q000008:administration & dosage*; D016292:Procedural Sedation / Q000379:methods*; D004311:Double-Blind Method; D004452:Echocardiography / Q000379:methods*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008874:Midazolam / Q000008:administration & dosage*; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D016896:Treatment Outcome
D002697:Chloral Hydrate; D008874:Midazolam