title: Glomerulonephritis associated with deficiencies and polymorphisms of complement components encoded in the class III region of the MHC.
abstract: An association between the complement system and immune complex glomerular disease in humans has long been recognized. In fact, much of our early understanding of the immunochemistry of complement activation developed with the study of acute and chronic glomerulonephritis (1). This manuscript will examine associations between glomerulonephritis and the three complement components encoded within the major histocompatibility complex: C4, C2, and factor B (B). The mechanisms by which deficiencies or polymorphisms in these components can mediate disease will be examined.
authors.affiliation: Division of Nephrology and Hypertension, Children's Hospital Research Foundation, Cincinnati, Ohio, USA. welct0@chmcc.org
authors.forename: T R
authors.initials: TR
authors.lastname: Welch
authors.forename: M
authors.initials: M
authors.lastname: Frenzke
mesh_terms: D003175:Complement C2 / Q000172:deficiency / Q000235:genetics; D003181:Complement C4 / Q000172:deficiency / Q000235:genetics; D011415:Complement Factor B / Q000172:deficiency / Q000235:genetics; D003165:Complement System Proteins / Q000172:deficiency* / Q000235:genetics*; D005921:Glomerulonephritis / Q000235:genetics* / Q000276:immunology*; D006801:Humans; D008285:Major Histocompatibility Complex; D011110:Polymorphism, Genetic
chemical_list: D003175:Complement C2; D003181:Complement C4; D003165:Complement System Proteins; D011415:Complement Factor B