Hypertonic-hyperoncotic solutions decrease cardiac troponin I concentrations in peripheral blood in a porcine ischemia-reperfusion model.
In this study we addressed the question of whether the measurement of cardiac Troponin I (cTnI) is able to reflect beneficial effects of hypertonic-hyperoncotic solutions after transient cardiac arrest. Ten pigs were anaesthetized and cardiac arrest was induced by electric fibrillation. After 5 minutes of global ischemia, cardiac arrest was reversed by electric defibrillation. Upon return of spontaneous circulation 5 animals received hypertonic-hyperoncotic solutions (10% Hydroxyethylstarch 200/0.5 and 7.2% NaCl). The other animals received equivalent volumes of physiological saline. We observed that cTnI serum levels of animals treated with hypertonic-hyperoncotic solutions were significantly lower than those treated with saline. We conclude that hypertonic-hyperoncotic solutions may have cardioprotective effects.
Bertsch
T
T
Institute for Clinical Chemistry, Klinikum Mannheim gGmbH, Faculty of Clinical Medicine Mannheim of the University of Heidelberg, Germany. thomas.bertsch@ikc.ma.uni-heidelberg.de
Denz
C
C
Janke
C
C
Weiss
M
M
Fassbender
K
K
Luiz
T
T
Ellinger
K
K
Krieter
H
H
D000818:Animals; D015415:Biomarkers / Q000097:blood; D004195:Disease Models, Animal; D006438:Hemodilution; D006454:Hemoglobins / Q000032:analysis; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D006982:Hypertonic Solutions / Q000627:therapeutic use*; D009206:Myocardium / Q000378:metabolism; D015427:Reperfusion Injury / Q000097:blood / Q000188:drug therapy*; D013552:Swine; D019210:Troponin I / Q000097:blood*
D015415:Biomarkers; D006454:Hemoglobins; D006895:Hydroxyethyl Starch Derivatives; D006982:Hypertonic Solutions; D019210:Troponin I