title: Molecular recognition by induced fit: how fit is the concept?
abstract: Induced fit explains why biomolecules can bind together even if they are not optimized for binding. However, induced fit can lead to a kinetic bottleneck and does not describe every interaction in the absence of prior complementarity. Preselection of a fitting conformer is an alternative to induced fit.
authors.affiliation: Department of Biochemistry, University of Zurich, CH-8057 Zurich, Switzerland.
authors.forename: H R
authors.initials: HR
authors.lastname: Bosshard
mesh_terms: D000936:Antigen-Antibody Complex / Q000502:physiology; D001688:Biological Products / Q000737:chemistry / Q000378:metabolism*; D008954:Models, Biological; D008968:Molecular Conformation
chemical_list: D000936:Antigen-Antibody Complex; D001688:Biological Products