Tissue factor: an enzyme cofactor and a true receptor.
Tissue factor is considered to be the physiologic trigger of the blood clotting system in normal hemostasis and in many--perhaps most--thrombotic diseases. A wealth of new knowledge is available regarding the structure and assembly of the TF:VIIa complex and the role of factor VIIa and tissue factor in hypercoagulable states. The exciting recent finding that tissue factor can function as a signaling receptor, and suggestions that tissue factor may have important, non-hemostatic roles, will be the subject of much additional study in the near future.
Morrissey
J H
JH
Department of Biochemistry, University of Illinois College of Medicine at Urbana-Champaign, 61801, USA. jim@tf7.org
D001777:Blood Coagulation / Q000187:drug effects; D015942:Factor VIIa / Q000737:chemistry / Q000378:metabolism / Q000502:physiology; D006801:Humans; D011485:Protein Binding; D011487:Protein Conformation; D019851:Thrombophilia / Q000209:etiology; D013925:Thromboplastin / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*
D013925:Thromboplastin; D015942:Factor VIIa