title: Resetting wave forms in dictyostelium territories.
abstract: The mechanism by which spiral wave patterns appear in populations of Dictyostelium was probed experimentally by external chemical perturbation. Spiral waves, which often arise from the breakup of circular waves driven by pacemakers, typically entrain those pacemakers. We studied these processes by resetting the waves with a spatially uniform pulse of extrinsic cyclic AMP. A pattern of spirals reappeared if resetting was early in the signaling stage, but only targets emerged following late resetting, in a manner analogous to cardiac defibrillation. This supports recent hypotheses that wave pattern selection naturally occurs by slow temporal variation of the excitability of the cells.
authors.affiliation: National Creative Research Initiative Center for Neurodynamics and Department of Physics, Korea University, Seoul 136-701 Korea.
authors.forename: K J
authors.initials: KJ
authors.lastname: Lee
authors.forename: R E
authors.initials: RE
authors.lastname: Goldstein
authors.forename: E C
authors.initials: EC
authors.lastname: Cox
mesh_terms: D000818:Animals; D000242:Cyclic AMP / Q000494:pharmacology / Q000502:physiology; D004023:Dictyostelium / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000235:genetics / Q000502:physiology; D013217:Starvation
chemical_list: D000242:Cyclic AMP