title: Exploiting anthracycline scaffold for designing DNA-targeting agents.
authors.affiliation: M. D. Anderson Cancer Center, University of Texas, Houston, Texas 77030, USA.
authors.forename: W
authors.initials: W
authors.lastname: Priebe
authors.forename: I
authors.initials: I
authors.lastname: Fokt
authors.forename: T
authors.initials: T
authors.lastname: Przewloka
authors.forename: J B
authors.initials: JB
authors.lastname: Chaires
authors.forename: J
authors.initials: J
authors.lastname: Portugal
authors.forename: J O
authors.initials: JO
authors.lastname: Trent
mesh_terms: D018943:Anthracyclines / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D001483:Base Sequence; D001665:Binding Sites; D020650:Combinatorial Chemistry Techniques; D004247:DNA / Q000737:chemistry* / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D003630:Daunorubicin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D015195:Drug Design; D005822:Genetic Vectors; D006801:Humans; D066298:In Vitro Techniques; D007364:Intercalating Agents / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008958:Models, Molecular; D009154:Mutation; D009690:Nucleic Acid Conformation; D013816:Thermodynamics; D014158:Transcription, Genetic / Q000187:drug effects; D014961:X-Ray Diffraction
chemical_list: D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D007364:Intercalating Agents; C104426:WP 631; D004247:DNA; D003630:Daunorubicin