Chronic intraventricular infusion of glial cell line-derived neurotrophic factor (GDNF) rescues some cerebellar Purkinje cells from heredodegeneration.
Cerebellar Purkinje cells degenerate in shaker mutant rats. Glia cell line-derived neurotrophic factor (GDNF) was chronically infused intraventricularly in an attempt to rescue mutant Purkinje cells from dying. Four weeks of chronic GDNF infusion delayed the degeneration of many but not all Purkinje cells. Surviving Purkinje cells formed spatially related groups interrupted by other groups of degenerated Purkinje cells. There was a positive correlation in GDNF-supported Purkinje cell survival and persistence of normal motor behaviors.
Tolbert
D L
DL
Francis and Doris Murphy Neuroanatomy Research Laboratory, Department of Anatomy and Neurobiology, Saint Louis University School of Medicine, St. Louis, Missouri 63104, USA.
Bradley
M W
MW
Tolod
E G
EG
Torres-Aleman
I
I
Clark
B R
BR
D000818:Animals; D002470:Cell Survival / Q000187:drug effects*; D002531:Cerebellum / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D002552:Cerebral Ventricles / Q000187:drug effects / Q000502:physiology*; D051100:Glial Cell Line-Derived Neurotrophic Factor; D007263:Infusions, Parenteral; D009410:Nerve Degeneration / Q000517:prevention & control*; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins / Q000008:administration & dosage / Q000494:pharmacology*; D011689:Purkinje Cells / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011922:Rats, Mutant Strains; D017208:Rats, Wistar
C495041:Gdnf protein, rat; D051100:Glial Cell Line-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins