N-Phthaloyl gamma-aminobutyric acid affects biochemical circadian rhythms in Wistar rats.
N-Phthaloyl gamma-aminobutyric acid (P-GABA) was administered to Wistar rats and 24 hr rhythms of glucose, cholesterol, total protein and lactic acid levels in blood were studied under semi-natural light dark conditions. P-GABA administration caused desynchronisation of the rhythms; while glucose and lactic acid rhythms were advanced, cholesterol and total protein rhythms were delayed. Since GABA is being involved in conveying dark information to the clock, exogenous administration of P-GABA may reduce the photic information received by the clock. The results could be explained by slightly less than 1 hr daily delays (or) advances respectively which would bring the peak times to the points 21 days after the start of administration.
Subramanian
P
P
Department of Biochemistry, Faculty of Science, Annamalai University, Tamil Nadu, India.
Sundaresan
S
S
Balamurugan
E
E
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D018755:GABA Agonists / Q000494:pharmacology; D019344:Lactic Acid / Q000097:blood; D008297:Male; D017440:Photoperiod; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives / Q000494:pharmacology*
D001786:Blood Glucose; D001798:Blood Proteins; D018755:GABA Agonists; C063763:N-phthaloyl-4-aminobutyric acid; D019344:Lactic Acid; D005680:gamma-Aminobutyric Acid; D002784:Cholesterol