[Fluoroquinolones: utilization in renal and urogenital tract infections].
The purpose of this review is to give an introduction in the class of fluoroquinolones, which has become a large class of substances, and to discuss the use, role, and place of these drugs in the treatment of urinary tract infections. The classification of the fluoroquinolones contains four groups. Antibacterial spectrum, pharmacokinetics, and indications are the main criteria. The various fluoroquinolones differ in their antibacterial spectrum, the antibacterial activity, and pharmacokinetic properties. Therefore selection, use, and dosage regime of the substances should be carried out under respective clinical requirements and medical points of view. The physician has to consider the specific indications for each substance in each individual case. Fluoroquinolones are suitable antibacterial agents for various urinary tract infections and are a valuable and useful addition to the antimicrobial treatment.
Farker
K
K
Institut für Klinische Pharmakologie, Klinikum der Friedrich-Schiller-Universität Jena. katrin.farker@med.uni-jena.de
Naber
K G
KG
Fünfstück
R
R
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D052776:Female Urogenital Diseases / Q000188:drug therapy*; D024841:Fluoroquinolones; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy*; D052801:Male Urogenital Diseases; D016032:Randomized Controlled Trials as Topic; D014552:Urinary Tract Infections / Q000188:drug therapy
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones