title: Effects of cumulative prenatal substance exposure and environmental risks on children's developmental trajectories.
abstract: Examined the effects of cumulative prenatal substance exposure and cumulative environmental risk on the developmental trajectories of 278 infants, toddlers, and preschool children. Results indicated that both cumulative risk indexes were significantly correlated. Results also indicated that both indexes were related to decrements in developmental trajectories (intercept and slope) from 3 to 57 months of age. Both prenatal exposure and environmental risk added unique variance to the prediction of developmental level and rate of growth when entered after covariates (i.e., birth weight and sex). However, across a number of models with and without covariates, environmental risk accounted for more variance in developmental trajectories than did prenatal exposure. Implications are discussed.
authors.affiliation: Juniper Gardens Children's Project, University of Kansas, USA. carta@ukans.edu
authors.forename: J J
authors.initials: JJ
authors.lastname: Carta
authors.forename: J B
authors.initials: JB
authors.lastname: Atwater
authors.forename: C R
authors.initials: CR
authors.lastname: Greenwood
authors.forename: S R
authors.initials: SR
authors.lastname: McConnell
authors.forename: M A
authors.initials: MA
authors.lastname: McEvoy
authors.forename: R
authors.initials: R
authors.lastname: Williams
mesh_terms: D000367:Age Factors; D002675:Child, Preschool; D015331:Cohort Studies; D002658:Developmental Disabilities / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D004781:Environmental Exposure / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D011237:Predictive Value of Tests; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D015203:Reproducibility of Results; D012189:Retrospective Studies; D012720:Severity of Illness Index