Peptide loading of nascent MHC class I molecules.
A critical molecular interaction during assembly of the major histocompatibility complex (MHC) class I molecules takes place between the heavy chain and the transporter-associated with antigen-processing (TAP) complex. The recent mapping of regions of the heavy chain involved in the binding to TAP suggests a complex molecular interaction essential for the cell surface expression of the MHC class I. The advances made in understanding the TAP-MHC class I interaction are reviewed and discussed here.
Vukmanović
S
S
Department of Pathology, and Kaplan Coprehensive Cancer Center, NYU School of Medicine, NY 10016, USA. vukmas01@med.nyu.edu
Lilić
M
M
Santori
F R
FR
Demaria
S
S
Kulig
K
K
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000737:chemistry / Q000378:metabolism*; D000483:Alleles; D017951:Antigen Presentation; D003600:Cytosol / Q000378:metabolism; D019281:Dimerization; D004721:Endoplasmic Reticulum / Q000378:metabolism; D015395:Histocompatibility Antigens Class I / Q000737:chemistry* / Q000502:physiology; D006801:Humans
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D015395:Histocompatibility Antigens Class I; C073119:TAP1 protein, human