Multiplolides A and B, new antifungal 10-membered lactones from Xylaria multiplex.
Two new 10-membered lactones, namely, multiplolides A (1) and B (2), were isolated from the broth extract of the fungus Xylaria multiplex BCC 1111. Chemical structures of 1 and 2 were elucidated on the basis of their spectral data. Multiplolides A (1) and B (2) exhibited antifungal activity against Candida albicans with IC(50) values of 7 and 2 microg/mL, respectively. Both 1 and 2 were inactive in the screening systems toward the malarial parasite Plasmodium falciparum (at 20 microg/mL) and were not cytotoxic to BC-1 and KB cell lines (at 20 microg/mL).
Boonphong
S
S
Department of Chemistry, Faculty of Science, Naresuan University, Phitsanulok 65000, Thailand.
Kittakoop
P
P
Isaka
M
M
Pittayakhajonwut
D
D
Tanticharoen
M
M
Thebtaranonth
Y
Y
D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001203:Ascomycota / Q000737:chemistry; D002176:Candida albicans / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured / Q000187:drug effects; D006801:Humans; D007624:KB Cells / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010963:Plasmodium falciparum / Q000187:drug effects / Q000378:metabolism; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013785:Thailand
D000935:Antifungal Agents; D007783:Lactones; C435879:multiplolide A; C435880:multiplolide B