A single oral administration of conjugated linoleic acid enhanced energy metabolism in mice.
We investigated the effect of a single oral administration of conjugated linoleic acid (CLA) on energy metabolism in mice. Male Std ddY mice were orally administered CLA (5 mL/kg weight) or linoleic acid (5 mL/kg weight) (both solutions at concentrations of 73.5%) as a control. Oxygen consumption was significantly greater in the CLA-administered mice than in the control mice. Respiratory quotient was slightly lower in the CLA-adminis-tered mice than in the control mice. We calculated fat and carbohydrate oxidation from oxygen consumption and respiratory quotient. Fat oxidation in the CLA-administered mice was significantly higher than in the control mice, and there was no difference in carbohydrate oxidation. Serum concentrations of noradrenalin and adrenalin in the CLA administered mice were significantly higher than in the control mice. These results suggested that CLA enhanced sympathetic nervous activity and energy metabolism.
Ohnuki
K
K
Department of Applied Life Sciences, Graduate School of Agriculture, Kyoto University.
Haramizu
S
S
Oki
K
K
Ishihara
K
K
Fushiki
T
T
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects; D050260:Carbohydrate Metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D008041:Linoleic Acids / Q000008:administration & dosage* / Q000737:chemistry; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009638:Norepinephrine / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005227:Fatty Acids; D008041:Linoleic Acids; D014280:Triglycerides; D009638:Norepinephrine; D004837:Epinephrine