Neurostimulation of the ventral intermediate thalamic nucleus in inherited myoclonus-dystonia syndrome.
We report on the effects of bilateral neurostimulation of the ventral intermediate thalamic nucleus (VIM) in a patient with medically intractable and progressing inherited myoclonus dystonia syndrome (IMDS). Postoperatively, the patient improved by approximately 80% on the modified version of a myoclonus score without any significant change in the dystonic symptoms. This suggests that neurostimulation of the VIM may be an effective treatment for myoclonus in pharmacologically intractable IMDS.
Trottenberg
T
T
Department of Neurology, Humboldt-University, Charité-Virchow, Berlin, Germany.
Meissner
W
W
Kabus
C
C
Arnold
G
G
Funk
T
T
Einhaupl
K M
KM
Kupsch
A
A
D001931:Brain Mapping; D004292:Dominance, Cerebral / Q000502:physiology; D020821:Dystonic Disorders / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D004599:Electric Stimulation Therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000235:genetics / Q000503:physiopathology / Q000628:therapy*; D009460:Neurologic Examination; D020651:Ventral Thalamic Nuclei / Q000503:physiopathology*