title: The design of self-replicating helical peptides.
abstract: The self-assembly of helical peptides and information transfer through autocatalysis and cross-catalysis are the foundation of peptide-based molecular evolution models. Many fundamental properties of living systems, such as environmental sensitivity, chiroselectivity, cross-catalysis, dynamic error correction and conditional selection, are exhibited by various self-replicating peptide systems. Recently, advances have been made in the design of peptide systems with autocatalytic and cross-catalytic properties.
authors.affiliation: Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, USA.
authors.forename: R
authors.initials: R
authors.lastname: Issac
authors.forename: Y W
authors.initials: YW
authors.lastname: Ham
authors.forename: J
authors.initials: J
authors.lastname: Chmielewski
mesh_terms: D000595:Amino Acid Sequence / Q000235:genetics; D002384:Catalysis; D004268:DNA-Binding Proteins; D019143:Evolution, Molecular; D005656:Fungal Proteins / Q000737:chemistry*; D008958:Models, Molecular; D008968:Molecular Conformation; D010448:Peptide Initiation Factors; D010455:Peptides / Q000138:chemical synthesis* / Q000737:chemistry*; D015202:Protein Engineering; D011494:Protein Kinases / Q000737:chemistry*; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D004268:DNA-Binding Proteins; C116123:E1E2 peptide; C116126:E1K2 peptide; D005656:Fungal Proteins; C116125:K1E2 peptide; C116124:K1K2 peptide; D010448:Peptide Initiation Factors; D010455:Peptides; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases