title: [Abdominoperineal resection for locally recurrent rectal cancers following anterior resection].
abstract: OBJECTIVE
  The aim of this retrospective study was to evaluate the short and long term results of abdominoperineal resection for local recurrence following low anterior resection of a rectal adenocarcinoma and to determine the prognostic factors.
  
  
  METHODS
  From January 1978 to December 1996, 35 patients (17 women, 18 men) with a mean age of 59.4 years, underwent an abdominoperineal resection for local recurrence after low anterior resection of a rectal adenocarcinoma. The primary tumor was below the peritoneum in 29 cases, and the mean security margin was 3 cm under the tumor. Tumor staging at the time of primary surgery included 23 Dukes B, 11 Dukes C, and 1 Dukes D. The mean time elapsed between low anterior resection and local recurrence was 16.4 months. The histological diagnosis of recurrence was obtained preoperatively in 29 cases (82.8%).
  
  
  RESULTS
  Resection was curative in 12 patients and palliative only in 23 patients. The recurrence was intramural in 3 cases, extramural in 10 cases, and mixed in 22 cases. Ten patients had an extended "en bloc" resection including one or several adjacent organs, and a synchronous metastasis was resected in 2 cases. The mortality rate was 2.8% (n = 1) and the morbidity rate was 23% (n = 8). The 1-year and 5-year survival rates were respectively 77 and 30.2% with the univariate analysis of prognosis factors of survival, there were four pretherapeutic factors (age, staging of the primary tumor, delay of the recurrence, CEA rate) and four therapeutic factors (curative resection, extramural recurrence, staging of the recurrence, postoperative radiotherapy). The curative or not curative type of resection was the only independent predictor of survival with multivariate analysis.
  
  
  CONCLUSIONS
  The results of this study seem to justify an abdominoperineal resection for local recurrence after low anterior resection whenever possible. Long-term results may possibly be improved by using adjuvant treatment.
authors.affiliation: Département de chirurgie viscérale, CHU Angers, 4, rue Larrey, 49033 Angers, France.
authors.forename: N
authors.initials: N
authors.lastname: Régenet
authors.forename: P
authors.initials: P
authors.lastname: Pessaux
authors.forename: J J
authors.initials: JJ
authors.lastname: Tuech
authors.forename: P
authors.initials: P
authors.lastname: Burtin
authors.forename: R
authors.initials: R
authors.lastname: du Plessis
authors.forename: J P
authors.initials: JP
authors.lastname: Arnaud
mesh_terms: D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D013505:Digestive System Surgical Procedures / Q000379:methods*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000601:surgery*; D010166:Palliative Care; D010502:Perineum / Q000601:surgery; D011379:Prognosis; D012004:Rectal Neoplasms / Q000473:pathology / Q000601:surgery*; D016896:Treatment Outcome