Prenatal diagnosis using fetal cells and free fetal DNA in maternal blood.
The presence of fetal cells and free fetal DNA in maternal blood offers an exciting opportunity for the development of safe noninvasive forms of prenatal diagnosis. Research in this field has, however, also indicated that their levels in the maternal circulation are increased in certain pregnancy-related disorders, such as preeclampsia. Their closer examination may shed new light on the underlying etiology of this enigmatic disorder.
Holzgreve
W
W
Department of Obstetrics and Gynecology, University of Basel, Basel, Switzerland. wholzgreve@uhbs.ch
Hahn
S
S
D018929:Cell Culture Techniques; D025063:Chromosome Disorders / Q000097:blood / Q000175:diagnosis*; D004247:DNA / Q000097:blood*; D005260:Female; D005333:Fetus / Q000166:cytology*; D006801:Humans; D008431:Maternal-Fetal Exchange; D016133:Polymerase Chain Reaction; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy / Q000097:blood*; D011296:Prenatal Diagnosis / Q000379:methods*
D004247:DNA