[Clinical study on Zishen Decoction in chronic uric acid nephrosis].
OBJECTIVE
To observe the ameliorative effect of Zishen Decoction (ZSD) on chronic uric acid nephrosis (CUAN).


METHODS
The 72 CUAN patients were divided into 2 groups: The group with ZSD treatment, the dose of which was 400 ml/d and group with zyloric as the control, the dose of which was 200 mg/d. The treatment lasted for 8 weeks.


RESULTS
The general effective rate of the ZSD group was 92.86%; and that of the control group Was 66.67%. There was significant difference between the two groups (P < 0.01). ZSD treatment reduced the levels of blood uric acid, serum creatinine and blood urea nitrogen and the levels of albumin, beta 2-microglobulin and the activity of N-acetyl-D-glucosaminidase in CUAN (P < 0.01). The levels of triglyceride and total cholesterol decreased and the levels of high density lipoprotein cholesterol increased in the serum of ZSD treated CUAN (P < 0.01).


CONCLUSIONS
ZSD exerted obviously ameliorative effect on renal function in CUAN.
Ni
Q
Q
Guang' anmen Hospital, China Academy of TCM, Beijing 100053.
Shi
Z
Z
Zheng
Q
Q
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009401:Nephrosis / Q000188:drug therapy* / Q000209:etiology; D019413:Qi; D014527:Uric Acid / Q000097:blood*; D016710:Yin Deficiency / Q000188:drug therapy
D004365:Drugs, Chinese Herbal; D014527:Uric Acid