title: Study of 2708 heroin-related deaths in north-eastern Italy 1985-98 to establish the main causes of death.
abstract: OBJECTIVE
  To ascertain the causes of deaths among a very large cohort of heroin injecting drug users (IDUs) who, from 1985 to 1998, attended 36 Public Health Authority Centres for Drug Users (PCDUs) in north-eastern Italy.
  
  
  METHODS
  Retrospective analysis of data, obtained from the Annual Register of each Centre and the Municipal Registry Office of each local health district.
  
  
  METHODS
  Thirty-six PCDUs in north-eastern Italy and Medical Service for Addictive Disorders of the University of Verona.
  
  
  METHODS
  All IDUs who had sought medical care at least once in the PCDUs during the study period.
  
  
  RESULTS
  Of 2708 deaths, overdose was found to be the major cause (37%), followed by AIDS (32.5%) and road accidents (9.4%). The percentage of deaths due to AIDS increased steadily from 2.7% in 1985 to 42.2% in 1996, and then decreased to 16.9% in 1998. Deaths due to overdose remained almost constant. The average age of death per year rose from 26 in the mid eighties to 34 in 1998. The mortality rate among IDUs proved much higher compared to the general population of the same age (13-fold, 95% CI, 11.3-14.6). The proportion of all deaths attributable to regular use of illegal opiates in the 15-34 age group in the general population in 1991 was 16%. HIV prevalence was not a significant factor in suicides and deaths by overdose.
  
  
  CONCLUSIONS
  The mortality rate was 13 times greater than in the general population. To be female and to have dropped out of any kind of treatment proved an important risk factor for overdose. The fall in deaths from AIDS enhances the problem to prevent and treat HCV infection. Decisions in drug projects, in research and in training should be influenced by the strikingly high percentage of deaths due to drug use.
authors.affiliation: Medical Service for Addictive Disorders, Department of Internal Medicine, University of Verona, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Quaglio
authors.forename: G
authors.initials: G
authors.lastname: Talamini
authors.forename: A
authors.initials: A
authors.lastname: Lechi
authors.forename: L
authors.initials: L
authors.lastname: Venturini
authors.forename: F
authors.initials: F
authors.lastname: Lugoboni
authors.forename: P
authors.initials: P
authors.lastname: Mezzelani
mesh_terms: D000063:Accidents, Traffic / Q000401:mortality; D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000704:Analysis of Variance; D002423:Cause of Death; D016009:Chi-Square Distribution; D062787:Drug Overdose / Q000401:mortality; D005260:Female; D003932:Heroin; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008297:Male; D010352:Patient Dropouts; D016012:Poisson Distribution; D012042:Registries; D012189:Retrospective Studies; D012307:Risk Factors; D012737:Sex Factors; D015819:Substance Abuse, Intravenous / Q000401:mortality* / Q000628:therapy
chemical_list: D003932:Heroin