LSD-induced Hallucinogen Persisting Perception Disorder treated with clonazepam: two case reports.
Benzodiazepines are recommended for the treatment of Hallucinogen Persisting Perception Disorder (HPPD), although it is unclear which may be more helpful. Two out-patients with LSD-induced HPPD were successfully treated with clonazepam. They had not responded to low potency benzodiazepines or low doses of classic antipsychotics. After clonazepam discontinuation they reported a marked improvement and only mild symptomatology which persisted during a six month follow-up period. High potency benzodiazepines like clonazepam, which has serotonergic properties, may be superior to low-potency benzodiazepines in the treatment of some patients with LSD-induced HPPD.
Lerner
A G
AG
Lev Hasharon Mental Health Medical Center, Pardessya, Israel. lerneram@internet-zahav.net
Skladman
I
I
Kodesh
A
A
Sigal
M
M
Shufman
E
E
D000328:Adult; D002998:Clonazepam / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000009:adverse effects*; D008297:Male; D010468:Perceptual Disorders / Q000139:chemically induced* / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D002998:Clonazepam; D008238:Lysergic Acid Diethylamide