Abolished angiogenicity and tumorigenicity of rat glioma by 1-naphthalenemonosulfonate.
Suramins and suradistas, an important group of potential anti-cancer agents, inhibit fibroblast growth factor (FGF) mitogenic activity. It has been shown that naphthalenesulfonates, with a common chemical function to the family of suramins and suradistas, mimic their inhibitory activity, abolishing FGF-induced angiogenesis in vivo, and inducing apoptosis of C6 glioma cells in culture. In the present report, we show that intratumoral administration of 1-naphthalenemonosulfonate induces a considerable regression of gliomas in rats, significantly enhances apoptosis, and attenuates tumor angiogenesis. These findings may lead to new approaches for the treatment of glioblastoma, a most common primary malignant brain tumor of very poor prognosis, as well as of other angiogenesis-dependent malignancies.
Cuevas
P
P
Departamento de Investigación, Hospital Universitario Ramón y Cajal, E-28034, Madrid, Spain. pedro.cuevas@hrc.es
Carceller
F
F
Diaz
D
D
Reimers
D
D
Fernández
M
M
Lozano
R M
RM
González-Corrochano
R
R
Giménez-Gallego
G
G
D020533:Angiogenesis Inhibitors / Q000494:pharmacology; D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D017209:Apoptosis / Q000187:drug effects; D001932:Brain Neoplasms / Q000188:drug therapy*; D005346:Fibroblast Growth Factors / Q000502:physiology; D005910:Glioma / Q000188:drug therapy*; D020287:In Situ Nick-End Labeling; D009282:Naphthalenesulfonates / Q000494:pharmacology*; D009368:Neoplasm Transplantation; D009389:Neovascularization, Pathologic / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014407:Tumor Cells, Cultured / Q000637:transplantation
D020533:Angiogenesis Inhibitors; D000970:Antineoplastic Agents; D009282:Naphthalenesulfonates; C435043:1-naphthalenesulfonic acid; D005346:Fibroblast Growth Factors