Suppressors of cancer cell proliferation from fig (Ficus carica) resin: isolation and structure elucidation.
A mixture of 6-O-acyl-beta-D-glucosyl-beta-sitosterols, the acyl moeity being primarily palmitoyl and linoleyl with minor amounts of stearyl and oleyl, has been isolated as a potent cytotoxic agent from fig (Ficuscarica) latex and soybeans. Identity was established by spectroscopic methods (NMR, MS) and confirmed by chemical synthesis. Both the natural and the synthetic compounds showed in vitro inhibitory effects on proliferation of various cancer cell lines.
Rubnov
S
S
Department of Medicinal Chemistry and Natural Products, School of Pharmacy, The Hebrew University, Jerusalem 91120, Israel.
Kashman
Y
Y
Rabinowitz
R
R
Schlesinger
M
M
Mechoulam
R
R
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005260:Female; D005638:Fruit / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D007840:Latex / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007938:Leukemia; D008223:Lymphoma; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D015674:Mammary Neoplasms, Animal; D013058:Mass Spectrometry; D010946:Plants, Medicinal / Q000737:chemistry*; D011471:Prostatic Neoplasms; D012855:Sitosterols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013025:Glycine max / Q000737:chemistry*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000972:Antineoplastic Agents, Phytogenic; D005960:Glucosides; D007840:Latex; D012855:Sitosterols