title: Oxygenator thrombosis: worst case after development of an abnormal pressure gradient--incidence and pathway.
abstract: The development of an abnormally high pressure gradient (APG) before the membrane oxygenator (MO) is a complication that occurs during some extracorporeal circulation (ECC) procedures. The present study deals with the incidence of an APG and discusses a probable causative pathway by comparing surface-coated and uncoated oxygenation systems. Five thousand six hundred and seventeen adult ECCs were carried out (2,581 without and 3,036 with surface coatings). The incidence of an APG, therefore, amounted to 0.03% in the group with coated systems and 4.3% in the uncoated group. In addition, an in vitro study demonstrated significantly reduced adhesion and activation of platelets and leucocytes when the surfaces of the MOs were coated with heparin or polypeptides. The advantages of coating surfaces of ECC devices possibly depend on the selective adsorption of particular plasma proteins. These will presumably form a biocompatible membrane on the surface, and minimize pathological deposit of fibrin, platelets and other blood cells, and, therefore, implicate the prevention of an oxygenator failure.
authors.affiliation: Clinic for Thoracic, Cardiac and Vascular Surgery, Eberhard-Karls-University, Tuebingen, Germany. hp.wendel@uni-buebingen.de
authors.forename: H P
authors.initials: HP
authors.lastname: Wendel
authors.forename: A
authors.initials: A
authors.lastname: Philipp
authors.forename: N
authors.initials: N
authors.lastname: Weber
authors.forename: D E
authors.initials: DE
authors.lastname: Birnbaum
authors.forename: G
authors.initials: G
authors.lastname: Ziemer
mesh_terms: D001792:Blood Platelets / Q000187:drug effects; D020099:Coated Materials, Biocompatible; D019544:Equipment Failure Analysis; D005112:Extracorporeal Circulation / Q000009:adverse effects / Q000295:instrumentation; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D010107:Oxygenators, Membrane / Q000009:adverse effects*; D010455:Peptides / Q000494:pharmacology; D011312:Pressure; D013927:Thrombosis / Q000209:etiology*
chemical_list: D020099:Coated Materials, Biocompatible; D010455:Peptides; D006493:Heparin