title: Mapping the organization of atrial fibrillation with basket catheters. Part II: Regional patterns in chronic patients.
abstract: The aim of this study was to investigate the spatial patterns of organization of fibrillation in the right atrium using bipolar recordings from a basket catheter in a population of 17 patients with persistent AF. The number of occurrences (NO) (i.e., the number of points laying on the baseline) was used as an objective measure of organization. This parameter significantly matches Wells' criteria for the classification of bipolar recordings during AF. The anatomic correspondence of the splines with eight atrial regions (namely anterior free wall, lateral free wall, posterolateral free wall, posterior free wall, posterior atrial septum, atrial septum, tricuspid valve, and anterior tricuspid valve) was assessed by fluoroscopic projections and electrogram morphology. Each region was further divided into high, mid-high, mid-low, and low segments. It was observed that individual and well-defined patterns of organization characterize the electrical activity of the right atrium in patients with persistent AF. When observed over 10 minutes, these patterns are rather stable in time. In each patient, the NO measurements were significantly different in the various right atrium regions (P < 0.0001 for all patients, Friedman test). The NO averaged over the population was significantly different among the regions (P < 0.001, Kruskal-Wallis test), owing to a common disorganized pattern observed in the tricuspid valve and anterior tricuspid valve regions. When these regions were removed from the analysis, the differences among the remaining regions were not statistically significant (P = 0.77). In conclusion, the quantitative assessment of organization in the entire right atrium showed an individual rather than common distribution. This may have implications in the choice of regions candidate for ablation.
authors.affiliation: Department of Internal Medicine and Cardiology, University of Firenze, Firenze. michelucci@cesit1.unifi.it
authors.forename: A
authors.initials: A
authors.lastname: Michelucci
authors.forename: P
authors.initials: P
authors.lastname: Bartolini
authors.forename: G
authors.initials: G
authors.lastname: Calcagnini
authors.forename: F
authors.initials: F
authors.lastname: Censi
authors.forename: A
authors.initials: A
authors.lastname: Colella
authors.forename: S
authors.initials: S
authors.lastname: Morelli
authors.forename: L
authors.initials: L
authors.lastname: Padeletti
authors.forename: P
authors.initials: P
authors.lastname: Pieragnoli
authors.forename: V
authors.initials: V
authors.lastname: Barbaro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001281:Atrial Fibrillation / Q000503:physiopathology*; D006328:Cardiac Catheterization / Q000295:instrumentation*; D002908:Chronic Disease; D004867:Equipment Design; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged