Hypoglycemia associated with clonidine testing for growth hormone deficiency.
We have observed 4 cases of hypoglycemia associated with clonidine stimulation of growth hormone secretion; only one patient had growth hormone deficiency. Significant drowsiness after administration of clonidine may prolong the period of fasting in these children and mask early signs and symptoms, leading to severe hypoglycemia.
Huang
C
C
Division of Endocrinology, Department of Pediatrics, University of Toronto and the Hospital for Sick Children, Toronto, Ontario, Canada.
Banerjee
K
K
Sochett
E
E
Perlman
K
K
Wherrett
D
D
Daneman
D
D
D000284:Administration, Oral; D000293:Adolescent; D001786:Blood Glucose / Q000187:drug effects*; D002675:Child, Preschool; D003000:Clonidine / Q000008:administration & dosage / Q000009:adverse effects*; D005215:Fasting / Q000378:metabolism*; D005260:Female; D013006:Growth Hormone / Q000172:deficiency*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D008297:Male; D012894:Sleep Stages / Q000187:drug effects
D001786:Blood Glucose; D013006:Growth Hormone; D003000:Clonidine