title: [Cefepime in the treatment of osteomyelitis caused by Gram negative bacilli].
abstract: We conducted a prospective, randomized, open-label trial to evaluate the efficacy and tolerability of cefepime in the treatment of osteomyelitis caused by Gram-negative bacilli. Hospitalized patients with diagnosis of osteomyelitis due to Gram-negative bacilli susceptible to cefepime were elegible for enrollment. Cefepime was administered intravenously or intramuscularly (2 g every 8 or 12 hours). Microorganisms were considered susceptible to cefepime when the MIC was <8 mg/l. Forty-five patients with bone infections were enrolled, forty-three with osteomyelitis (22 chronic and 21 acute) and two with arthritis. In the per protocol analysis 42 patients were evaluated: 30 (71.4%) were cured. In the intent to treat analysis 45 patients were evaluated: 33 (73.3%) were cured. Our trial suggests that cefepime is as effective as other modern parenteral beta-lactam antibiotics in the treatment of osteomyelitis due to Gram-negative bacilli.
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Gómez Ulla, Madrid.
authors.forename: J
authors.initials: J
authors.lastname: Barberán
authors.forename: M
authors.initials: M
authors.lastname: Gomis
authors.forename: B
authors.initials: B
authors.lastname: Sánchez
authors.forename: J
authors.initials: J
authors.lastname: Hernández-Salván
authors.forename: L
authors.initials: L
authors.lastname: García Del Salto
authors.forename: G
authors.initials: G
authors.lastname: Carroquino
authors.forename: F
authors.initials: F
authors.lastname: González
authors.forename: M
authors.initials: M
authors.lastname: Hernández
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000077723:Cefepime; D002511:Cephalosporins / Q000627:therapeutic use*; D002908:Chronic Disease; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy* / Q000382:microbiology; D018579:Patient Selection
chemical_list: D002511:Cephalosporins; D000077723:Cefepime