[Clinical studies on the effects of burn trauma on pituitary-testis axis].
OBJECTIVE
To investigate the effects of burn trauma on pituitary-testis axis.


METHODS
The changes in serum estradiol(E2), testosterone(T), luteinizing hormone(LH), and follicle stimulating hormone(FSH) levels were dynamically investigated by RIA in 30 days after thermal injury in 28 burnt men.


RESULTS
The serum FSH, LH, and T levels significantly decreased after injury, and there was some increase from PBD(postburn day) 14 to 30. In patients in group II and III (BSA > 30% TBSA), not all of their FSH, LH, and T levels reached the normal control on the PBD 30. Serum E2 levels were elevated after injury, then returned gradually to normal. In three patients who died, their mean T levels were significantly lower than patients who survived, but mean E2 levels were significantly higher than that of survivors.


CONCLUSIONS
The activity of pituitary might be depressed after burn trauma. The imbalance between E2 and T might play a role in the processes of immuno-depression after injury. The changed extent of E2 and T levels was correlated to burn size. They could be sensitive indicators of burn stress.
Da
M
M
Department of Burns, Second Affiliated Hospital of Kunming Medical College, KunMing 650101.
Ma
K
K
Duan
T
T
D000293:Adolescent; D000328:Adult; D002056:Burns / Q000097:blood / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000502:physiology*; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000097:blood*
D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone