Sulfated polysaccharides, but not cellulose, increase colonic mucus in rats with loperamide-induced constipation.
Colonic mucus is decreased in a rat model of spastic constipation, and some types of water-insoluble dietary fiber increase colonic mucus when consumed by rats for several weeks. However, little is known about the effect of water-soluble dietary fiber on the colonic mucus. The aim of the present study was to investigate the effect of various types of water-soluble dietary fiber on colonic mucus in a rat model of spastic constipation. Oral administration of 1.5 mg/day of carrageenan and chondroitin sulfate increased the fecal excretion, epithelial mucin production, thickness of the mucous layer, and amount of luminal mucus in loperamide-administered rats. Sodium alginate, 5 mg/day, thickened the mucus layer at the fecal surface. Cellulose, 5 mg/day, increased the fecal excretion but not the colonic mucus. Carrageenan, chondroitin sulfate, and sodium alginate, but not cellulose, increased colonic mucus in the rat model of spastic constipation.
Shimotoyodome
A
A
Biological Science Laboratories, Kao Corporation, Haga-gun, Tochigi, Japan.
Meguro
S
S
Hase
T
T
Tokimitsu
I
I
Sakata
T
T
D000464:Alginates / Q000494:pharmacology; D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D002482:Cellulose / Q000494:pharmacology*; D002809:Chondroitin Sulfates / Q000494:pharmacology; D003106:Colon / Q000378:metabolism*; D003248:Constipation / Q000139:chemically induced / Q000378:metabolism*; D004043:Dietary Fiber / Q000494:pharmacology; D004195:Disease Models, Animal; D020723:Glucuronic Acid; D006603:Hexuronic Acids; D008139:Loperamide; D008297:Male; D009093:Mucus / Q000378:metabolism*; D011134:Polysaccharides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000464:Alginates; D004043:Dietary Fiber; D006603:Hexuronic Acids; D011134:Polysaccharides; D008139:Loperamide; D020723:Glucuronic Acid; D002351:Carrageenan; D002482:Cellulose; D002809:Chondroitin Sulfates