DC-SIGN and LFA-1: a battle for ligand.
The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity.
Bleijs
D A
DA
Dept of Tumor Immunology, University Medical Center Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands.
Geijtenbeek
T B
TB
Figdor
C G
CG
van Kooyk
Y
Y
D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D037102:Lectins / Q000737:chemistry / Q000276:immunology*; D037181:Lectins, C-Type; D008024:Ligands; D016169:Lymphocyte Function-Associated Antigen-1 / Q000737:chemistry / Q000276:immunology*; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin
D015815:Cell Adhesion Molecules; D037102:Lectins; D037181:Lectins, C-Type; D008024:Ligands; D016169:Lymphocyte Function-Associated Antigen-1; D011956:Receptors, Cell Surface; D000099215:DC-Specific ICAM-3 Grabbing Nonintegrin