Beneficial effect of intravenous lidocaine in cutaneous chronic graft-versus-host disease secondary to donor lymphocyte infusion.
We report two cases of refractory chronic graft-versus-host disease after donor lymphocyte infusions in which the skin lesions improved dramatically with the use of intravenous pulses of lidocaine. This form of therapy has been used successfully for the cutaneous involvement of scleroderma and may have vasodilator and anti-inflammatory effects.
Voltarelli
J C
JC
Bone Marrow Transplantation Unit, University Hospital, School of Medicine of Ribeirão Preto, University of São Paulo, Brazil.
Ahmed
H
H
Paton
E J
EJ
Stracieri
A B
AB
Holman
P
P
Bashey
A
A
Coutinho
M
M
Simoes
B P
BP
Ball
E D
ED
Carrier
E
E
D000328:Adult; D016026:Bone Marrow Transplantation; D002648:Child; D002908:Chronic Disease; D005260:Female; D006086:Graft vs Host Disease / Q000188:drug therapy / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007275:Injections, Intravenous; D007938:Leukemia / Q000150:complications / Q000628:therapy; D008012:Lidocaine / Q000008:administration & dosage*; D017710:Lymphocyte Transfusion / Q000009:adverse effects*; D008297:Male; D012008:Recurrence; D012594:Scleroderma, Localized / Q000188:drug therapy / Q000209:etiology / Q000473:pathology; D012871:Skin Diseases / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D014184:Transplantation, Homologous
D008012:Lidocaine