[Clinical study on Shuanghuanglian powder in treating children viral myocarditis].
OBJECTIVE
To study immune function of children viral myocarditis and to evaluate the clinical effect of Shuanghuanglian Powder (SHLP).


METHODS
The authors determined serum COXB-IgM and the numbers of lymphocyte subsets CD3+, CD4+, CD8+, CD4+/CD8+ with viral myocarditis patients by ELISA and indirect immunofluorescent assay. Sixty-two cases were divided randomly into two groups. Thirty-two cases treated by conventional therapy with SHLP and the other 30 cases treated with conventional therapy alone were taken as control group.


RESULTS
COXB-IgM was positive in 39 of 62 patients, which were significantly different with those of normal controls (P < 0.001). In addition, the level of CD4+ cells and the ratio of CD4+/CD8+ were decreased while CD8+ increased. After treatment with SHLP, the recovery of symptoms, signs and immune function in patients were better than that of controls. These changes were significantly different (P < 0.01).


CONCLUSIONS
There were disturbance of immune regulatory function with children viral myocarditis patients and SHLP is an effective drug in treating children viral myocarditis.
Lin
G
G
Ruijin Hospital, Shanghai Second Medical University, Shanghai 200025.
Liu
D
D
Zhu
L
L
D000255:Adenosine Triphosphate / Q000627:therapeutic use; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003065:Coenzyme A / Q000627:therapeutic use; D003384:Coxsackievirus Infections / Q000188:drug therapy* / Q000276:immunology; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009205:Myocarditis / Q000188:drug therapy* / Q000276:immunology / Q000821:virology; D016176:T-Lymphocyte Subsets / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D000255:Adenosine Triphosphate; D003065:Coenzyme A