title: [The characteristics of clinical course of chronic hepatitis B and liver cirrhosis pathology of child patient].
abstract: OBJECTIVE
  To study the characteristics of clinical course of chronic hepatitis B and liver cirrhosis pathology of the child patients.
  
  
  METHODS
  The serum test for hepatitis A/B/C/E, the liver function test and the liver puncture for pathological examination were performed in 66 child patients with chronic hepatitis B.
  
  
  RESULTS
  The age, clinical course and form of disease onset, showed no-obvious difference between S0 group (without liver cirrhosis) and group > or = S3 (with evident liver cirrhosis). The cases with splenomegaly accounted for 2.9% in S0 group, but 32.3% in group > or = S3. The Hbe Ag positive rate of group S0 was apparently higher than that of group > or = S3 (74.29% and 29.03%, respectively). The higher the activity of liver inflammation, the more serious the extent of liver cirrhosis.
  
  
  CONCLUSIONS
  The liver cirrhosis of child patients with chronic hepatitis B has nothing to do with their age, clinical course, form of disease onset and virus replication, but it is in direct connection with the liver inflammation activity. If splenomegaly occurs and thrombin acts abnormally, albumin in serum decreases while gamma-globulin increases, the liver cirrhosis should be highly watched out for.
authors.affiliation: Department of Infectious Diseases, General Hospital of Jihua Group Company of Chemical Industry, Jilin 132002, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Ma
authors.forename: H
authors.initials: H
authors.lastname: Zhang
authors.forename: M
authors.initials: M
authors.lastname: Piao
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D002648:Child; D005260:Female; D006513:Hepatitis B e Antigens / Q000097:blood; D019694:Hepatitis B, Chronic / Q000097:blood / Q000150:complications / Q000473:pathology*; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology*; D008297:Male; D011516:Prothrombin / Q000032:analysis; D012709:Serum Albumin / Q000032:analysis
chemical_list: D006513:Hepatitis B e Antigens; D012709:Serum Albumin; D011516:Prothrombin; D000410:Alanine Transaminase