Reactive species in viral pneumonitis: lessons from animal models.
Recent evidence suggests that pneumonitis induced by many important human viral pathogens may result from exuberant generation of reactive species by inflammatory cells in response to infection. This review summarizes current evidence from animal model studies regarding the beneficial (antiviral) and harmful (tissue-damaging) effects of reactive species for the host.
Davis
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Department of Comparative Medicine, University of Alabama at Birmingham, Birmingham, Alabama 35233-6810, USA.
Matalon
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S
D000818:Animals; D005609:Free Radicals / Q000378:metabolism*; D006801:Humans; D009584:Nitrogen / Q000378:metabolism*; D011024:Pneumonia, Viral / Q000378:metabolism*; D017382:Reactive Oxygen Species / Q000378:metabolism*
D005609:Free Radicals; D017382:Reactive Oxygen Species; D009584:Nitrogen