title: The parkin gene is not a major susceptibility locus for typical late-onset Parkinson's disease.
abstract: We investigated the parkin gene in 118 patients with typical Parkinson's disease (PD), i.e. in patients who had an onset of PD after the age of 45 years. The study group included 95 subjects with sporadic PD and 23 subjects from 18 families with autosomal recessive PD. No pathogenetic mutations in the parkin gene were detected either in familial or in sporadic patients. Our findings indicate that the parkin gene is not involved in the pathogenesis of classic late-onset PD.
authors.affiliation: Neurology Clinic, University of Catanzaro, Italy.
authors.forename: R L
authors.initials: RL
authors.lastname: Oliveri
authors.forename: M
authors.initials: M
authors.lastname: Zappia
authors.forename: G
authors.initials: G
authors.lastname: Annesi
authors.forename: F
authors.initials: F
authors.lastname: Annesi
authors.forename: P
authors.initials: P
authors.lastname: Spadafora
authors.forename: A A
authors.initials: AA
authors.lastname: Pasqua
authors.forename: C
authors.initials: C
authors.lastname: Tomaino
authors.forename: G
authors.initials: G
authors.lastname: Nicoletti
authors.forename: D
authors.initials: D
authors.lastname: Bosco
authors.forename: D
authors.initials: D
authors.lastname: Messina
authors.forename: G
authors.initials: G
authors.lastname: Logroscino
authors.forename: G
authors.initials: G
authors.lastname: Manobianca
authors.forename: A
authors.initials: A
authors.lastname: Epifanio
authors.forename: L
authors.initials: L
authors.lastname: Morgante
authors.forename: G
authors.initials: G
authors.lastname: Savettieri
authors.forename: A
authors.initials: A
authors.lastname: Quattrone
mesh_terms: D017668:Age of Onset; D000368:Aged; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D004252:DNA Mutational Analysis; D005091:Exons / Q000235:genetics; D005260:Female; D005808:Genes, Recessive / Q000235:genetics; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D005820:Genetic Testing; D006801:Humans; D008025:Ligases / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D020734:Parkinsonian Disorders / Q000235:genetics*; D017354:Point Mutation / Q000235:genetics*; D044767:Ubiquitin-Protein Ligases
chemical_list: D044767:Ubiquitin-Protein Ligases; C111567:parkin protein; D008025:Ligases