Renal effects of cyclooxygenase-2 selective inhibitors.
Recent in-vitro and animal data show that cyclooxygenase-2 has an integral role in the physiology and pathophysiology of the kidney. Cyclooxygenase-2 regulates renin-angiotensin secretion, and thereby glomerular filtration rate and sodium homeostasis. It is also important for protecting against hypertonic stress. As a consequence, it is not surprising that clinical data verify that selective inhibitors of cyclooxygenase-2 affect renal function to a degree similar to that which has previously been documented with nonselective nonsteroidal anti-inflammatory drugs.
Harris
C J
CJ
Division of Clinical Pharmacology, Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA. cyharris@iupui.edu
Brater
D C
DC
D051546:Cyclooxygenase 2; D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors* / Q000502:physiology; D007668:Kidney / Q000187:drug effects*; D007672:Kidney Cortex / Q000201:enzymology; D007679:Kidney Medulla / Q000201:enzymology; D008565:Membrane Proteins; D011451:Prostaglandin-Endoperoxide Synthases / Q000502:physiology
D052246:Cyclooxygenase 2 Inhibitors; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D008565:Membrane Proteins; D051546:Cyclooxygenase 2; C496540:PTGS2 protein, human; D011451:Prostaglandin-Endoperoxide Synthases