Protist tubulins: new arrivals, evolutionary relationships and insights to cytoskeletal function.
The protists exhibit probably the most extravagant expression of microtubule-containing structures found in any organism. These structures--flagella, cilia, axostyles, spindles and a veritable constellation of microtubule bundles and cortical arrays--provide shape, form, motility, anchorage and apparatuses for feeding. The cytoskeletal structures have a precise order (i.e. size, position and number) that must be replicated and segregated with fidelity at each division, some components being inherited conservatively and others semi-conservatively. Intriguingly, it is now apparent that much of the high-order organisation, which was recognised and described by light and electron microscopy during the last century, is a reflection of molecular polarities set by assembly of constituent proteins. Tubulins and microtubules lie at the heart of this morphogenetic pattern.
Gull
K
K
School of Biological Sciences, University of Manchester, 2.205 Stopford Building, Oxford Road, Manchester M13 9PT, UK. K.Gull@man.ac.uk
D000818:Animals; D003599:Cytoskeleton / Q000378:metabolism*; D056890:Eukaryota / Q000235:genetics / Q000378:metabolism; D019143:Evolution, Molecular; D014404:Tubulin / Q000235:genetics* / Q000378:metabolism*
D014404:Tubulin