Antigen presentation to CD8+ T cells: cross-priming in infectious diseases.
Recent studies indicate that, in most types of infections, antigen presentation by 'professional' bone-marrow-derived cells is essential for priming pathogen-specific CD8+ T cells. This is true even in the absence of direct infection of these cells, which indicates that cross-priming is an essential component of the immune response against pathogens.
den Haan
J M
JM
Department of Immunology, Howard Hughes Medical Institute, University of Washington, Box 357370, Seattle, WA 98195-7370, USA. jdenhaan@u.washington.edu
Bevan
M J
MJ
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells / Q000276:immunology; D017209:Apoptosis / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology*; D003141:Communicable Diseases / Q000276:immunology* / Q000473:pathology; D003713:Dendritic Cells / Q000276:immunology; D006801:Humans; D009336:Necrosis