Liver transplantation of hepatic stem cells: potential use for treating liver diseases.
Hepatic stem cells are an alternative means for repopulating the liver after various injuries instead of liver transplantation. The first step before use is to select stem cells that will be good candidates. This review discusses the different candidates including fetal progenitor bipotential hepatic stem cells; adult hepatocytes, which can be considered as unipotential committed stem cells; and oval cells, a type of nonparenchymal pluripotential hepatic stem cell. The advantages and disadvantages of each type of cell are discussed and several other possible alternatives, such as the use of hematopoietic stem cells are analyzed.
Feldmann
G
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Laboratoire de Biologie Cellulaire, INSERM U.327, CHU Bichat-Claude Bernard, Université Paris 7, France. u327@bichat.inserm.fr
D000818:Animals; D017690:Cell Transplantation / Q000379:methods*; D005333:Fetus / Q000166:cytology; D022781:Hepatocytes / Q000378:metabolism / Q000637:transplantation*; D006801:Humans; D008099:Liver / Q000166:cytology* / Q000378:metabolism / Q000503:physiopathology; D008107:Liver Diseases / Q000601:surgery*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000502:physiology