[The effect of intradermal injection of collagenase in implanted hypertrophic scar in nude mice].
OBJECTIVE
Effects of collagen degradation in hypertrophic scar by intradermal injection of collagenase were observed.


METHODS
Hypertrophic scar was implanted into nude mice and collagenase was injected locally. Light and electron microscopic observations were carried out.


RESULTS
Collagen degradation in hypertrophic scar by intradermal injection of collagenase was observed. The implanted scars became soft, thin and small.


CONCLUSIONS
These results suggested that local injection of collagenase may be a useful therapeutic tool for hypertrophic scar.
Wu
J
J
Department of Physical Medicine and Rehabilitation, Southwest Hospital, Third Military Medical University, Chongqing 400038.
Chen
D
D
Wu
Z
Z
D000818:Animals; D017439:Cicatrix, Hypertrophic / Q000188:drug therapy* / Q000601:surgery; D017364:Collagenases / Q000008:administration & dosage*; D004195:Disease Models, Animal; D007271:Injections, Intradermal; D051379:Mice; D008819:Mice, Nude; D011897:Random Allocation
D017364:Collagenases