Pharmacologic modulation of human cerebral activity: contribution of functional neuroimaging.
This article highlights the following: (1) How the tools of functional neuroimaging analyze the effect of drug therapy on the central nervous system; (2) how the interactions between the drugs and the cortical neuronal networks have illustrated new aspects of the concepts of cerebral neuroplasticity; and (3) how functional neuroimaging has proved to be a valuable tool in understanding the mechanisms that govern the therapeutic activity of experimental drugs.
Chollet
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INSERM U455 and Fédération de Neurologie, Hôpital Purpan, Toulouse, France.
D000927:Anticonvulsants / Q000494:pharmacology*; D000978:Antiparkinson Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D001931:Brain Mapping; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D008279:Magnetic Resonance Imaging; D011939:Mental Recall / Q000187:drug effects / Q000502:physiology; D017981:Receptors, Neurotransmitter / Q000187:drug effects / Q000502:physiology; D014055:Tomography, Emission-Computed
D000927:Anticonvulsants; D000978:Antiparkinson Agents; D017981:Receptors, Neurotransmitter