[Effect of Yangxue bushen tablet on ovarian function in animal model of Yang deficiency].
OBJECTIVE
To study the therapeutic mechanism of Yangxue Bushen tablet (tablet for nourishing blood and tonifying Kidney) on the Kidney deficiency type of functional amenorrhea and infrequent menstruation.


METHODS
Applied with orimeten, models of Yang deficiency in female rabbits were made, ikaclomine was taken as the control drug. Group I was the group of animal model of Yang deficiency; Group II was the ikaclomine treatment group; Group III was the high dosage treatment group; Group IV was the low dosage group; Group V normal rabbit treated with distilled water. The functional effect of gonadal axis was evaluated by the changes of the signs of animal histomorphology of ovary and uterus, and the level of beta-endorphin.


RESULTS
The animals of Yang deficiency in Group II, III and IV recovered as a whole, and the changes of different levels of folliculi, morphosis of endometria and deciduous vaginal epithelial cell in group II, III and IV were more obviously than those in group I and V (P < 0.05). The content of beta-endorphin in blood plasma in group I was 106.6 pg/ml, which was lower than those in the other groups (P < 0.05), and the contents of beta-endorphin in blood plasma, in group III, IV and II were similar to that in group V (P < 0.05).


CONCLUSIONS
Yangxue Bushen tablet has the effect on regulating menstruation by regulating the function of gonadal axis, regulating and promoting the ovarian function.
Cai
L
L
Xiyuan Hospital, China Academy of Traditional Chinese Medicine, Beijing 100091.
Li
H
H
Wei
Y
Y
D000568:Amenorrhea / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D010053:Ovary / Q000473:pathology / Q000503:physiopathology*; D011817:Rabbits; D011897:Random Allocation; D016711:Yang Deficiency / Q000473:pathology / Q000503:physiopathology*; D001615:beta-Endorphin / Q000097:blood
D004365:Drugs, Chinese Herbal; D001615:beta-Endorphin