The transcription factor Egr-1: a potential drug in wound healing and tissue repair.
In the United States, between 40 and 90 million hospital days are lost per year as a result of trauma and surgical procedures which result in the loss of functional tissue. This is estimated to cost the economy and healthcare providers in excess of US$ 500 billion, a figure that is increasing because of extending population lifespan. Tissue engineering and gene therapies are radical new treatments that are aimed at tissue regeneration ranging from dermal, osteal and occular repair to the replacement of failing tissue with entire biosynthetic organs. Over the last decade, numerous proteins have been identified that are able to direct the synthesis of new tissue. Such proteins include growth factors, cytokines and, more recently, transcription factors.
Braddock
M
M
Disease Cell Biology Unit, GlaxoWellcome Medicines Research Centre, Stevenage, Herts, UK. martin.braddock@astrazeneca.com
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D015415:Biomarkers / Q000032:analysis; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use*; D051766:Early Growth Response Protein 1; D005656:Fungal Proteins / Q000378:metabolism; D005786:Gene Expression Regulation; D006801:Humans; D017874:Immediate-Early Proteins; D009687:Nuclear Proteins / Q000378:metabolism; D010003:Osteoarthritis / Q000188:drug therapy; D011379:Prognosis; D011401:Promoter Regions, Genetic; D016601:RNA-Binding Proteins / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors / Q000235:genetics / Q000378:metabolism* / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
D015415:Biomarkers; D004268:DNA-Binding Proteins; C497325:EGR1 protein, human; D051766:Early Growth Response Protein 1; D005656:Fungal Proteins; D017874:Immediate-Early Proteins; C077734:NPL3 protein, S cerevisiae; D009687:Nuclear Proteins; D016601:RNA-Binding Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors