[Studies on association between lipoprotein lipase gene polymorphisms of Pvu II site and hypertriglyceridemics in Chinese].
OBJECTIVE
To explore whether Pvu II restriction fragment length polymorphisms (RFLP) in the lipoprotein lipase(LPL) gene are associated with hypertriglyceridemics (HTG).


METHODS
Pvu II restriction fragment length polymorphisms in the lipoprotein lipase gene on a sample of 135 HTG patients and 193 age-matched healthy individuals in Chengdu area were detected with the method of PCR-RFLP.


RESULTS
The P+ P+ genotype frequency and P+ allelic frequency of LPL gene for HTG cases are higher than those for control groups (0.460 vs 0.337,P<0.05; 0.689 vs 0.565,P<0.01). The serum levels of TGapoCII, apoCIII, apoE and TG/HDL-C in P+P+ genotype are higher than those in P-P- genotype(P<0.05).


CONCLUSIONS
The results suggest that P+P+ genotype in the lipoprotein lipase gene is associated with susceptibility to hypertriglyceridemics in Chinese population.
Fan
Y
Y
Department of Moleculer Biology and Biochemistry, West China University of Medical Sciences, Chengdu, Sichuan 610041 P.R.China.
Zhang
R
R
Liu
B
B
Zhang
Z
Z
D000328:Adult; D000368:Aged; D044466:Asian People / Q000235:genetics*; D004262:DNA Restriction Enzymes / Q000235:genetics / Q000378:metabolism; D005787:Gene Frequency / Q000235:genetics*; D005838:Genotype; D006801:Humans; D015228:Hypertriglyceridemia / Q000235:genetics*; D008071:Lipoprotein Lipase / Q000235:genetics*; D008875:Middle Aged; D011110:Polymorphism, Genetic
D008071:Lipoprotein Lipase; D004262:DNA Restriction Enzymes