title: Subcutaneous hemangiosarcomas in a rhesus macaque (Macaca mulatta).
abstract: Hemangiosarcoma is a malignant tumor of vascular endothelial cell origin. The occurrence of hemangiosarcoma in nonhuman primates has been rarely documented. An adult male rhesus monkey was reported having a firm subcutaneous swelling, approximately 4.5 cm in diameter, on the ventral midline of the abdomen. Fine-needle aspiration, microbial culture, biopsy, radiographs, exploratory laparotomy, histopathology, immunohistochemistry, hematology, and serology were performed. A second subcutaneous mass approximately 4.5 x 4.0 x 2.7 cm developed on the ventral midline several weeks later. A fine-needle aspirate of the first mass consisted of numerous erythrocytes with few polymorphonuclear cells and lymphocytes. Histopathology showed foci of spindle-shaped cells surrounding the vascular spaces. Many spindle-shaped cells had prominent nucleoli, and mitotic figures could occasionally be seen. Immunohistochemical staining of the masses for Factor VIII-related antigen, an endothelial cell and tumor marker, yielded positive results. Both masses were consistent with hemangiosarcoma.
authors.affiliation: Unit for Laboratory Animal Medicine, The University of Michigan, Ann Arbor 48109-0614, USA. ddmyers@umich.edu
authors.forename: D D
authors.initials: DD
authors.lastname: Myers
authors.forename: R C
authors.initials: RC
authors.lastname: Dysko
authors.forename: C E
authors.initials: CE
authors.lastname: Chrisp
authors.forename: J L
authors.initials: JL
authors.lastname: Decoster
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology / Q000662:veterinary*; D000818:Animals; D014408:Biomarkers, Tumor / Q000032:analysis*; D001706:Biopsy; D004912:Erythrocytes; D006394:Hemangiosarcoma / Q000473:pathology / Q000662:veterinary*; D007150:Immunohistochemistry; D008214:Lymphocytes; D008253:Macaca mulatta; D008297:Male
chemical_list: D014408:Biomarkers, Tumor