Masquerade syndrome: T-cell prolymphocytic leukemia presenting as panuveitis.
OBJECTIVE
To report a case of T-cell prolymphocytic leukemia with panuveitis as the primary presenting feature.


METHODS
Case report.


RESULTS
A 46-year-old woman presented with pain and blurred vision in the right eye. She was found to have signs of panuveitis with a central exudative retinal detachment. Further investigations revealed that she was suffering from the rare T-cell prolymphocytic leukemia. Both systemic and ocular manifestations of the disease resolved after chemotherapy with Campath-IH antigen and as she went into complete remission. The exudative detachment settled, and visual acuity recovered to 20/20.


CONCLUSIONS
This case illustrates that leukemias can present with primarily ocular findings, and the sudden appearance of a serous retinal detachment with inflammatory signs in an otherwise healthy person warrants a thorough systemic screening for an underlying malignancy.
Dhar-Munshi
S
S
Croydon Eye Unit, Mayday University Hospital, Thornton Heath, Surrey, United Kingdom. sunil@webleicester.co.uk
Alton
P
P
Ayliffe
W H
WH
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000074301:CD52 Antigen; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D006023:Glycoproteins; D006801:Humans; D015463:Leukemia, Prolymphocytic / Q000175:diagnosis* / Q000188:drug therapy; D015458:Leukemia, T-Cell / Q000175:diagnosis* / Q000188:drug therapy; D008875:Middle Aged; D015864:Panuveitis / Q000175:diagnosis* / Q000188:drug therapy; D012163:Retinal Detachment / Q000175:diagnosis; D019572:Retinal Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D013577:Syndrome; D014792:Visual Acuity
D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000074301:CD52 Antigen; C000613862:CD52 protein, human; D006023:Glycoproteins