title: Preliminary experiment of fluorescent X-ray computed tomography to detect dual agents for biological study.
abstract: The simultaneous observation of various information, such as blood flow, tissue metabolism and distribution of receptors, is quite important in order to understand the functional state of biomedical objects. The simultaneous detectability of contrast agents by fluorescent X-ray computed tomography (FXCT) with synchrotron radiation is examined in this study. The system consisted of a silicon (111) double-crystal monochromator, an X-ray slit system, a scanning table, a PIN diode, a highly purified germanium detector and an X-ray charge-coupled device (CCD) camera. The monochromatic X-ray beam energy was adjusted to 37.0 keV and collimated into a pencil beam of 1 x 1 mm. The fluorescent spectra of the K alpha lines for iodine and xenon were detected simultaneously. FXCT could image the distribution of both iodine and xenon agents in a phantom clearly and the contrast ratio was significantly better than that of transmission X-ray computed tomography images.
authors.affiliation: Institute of Clinical Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-8575, Japan.
authors.forename: Q
authors.initials: Q
authors.lastname: Yu
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: T
authors.initials: T
authors.lastname: Yuasa
authors.forename: Y
authors.initials: Y
authors.lastname: Hasegawa
authors.forename: J
authors.initials: J
authors.lastname: Wu
authors.lastname: Thet-Thet-Lwin
authors.forename: K
authors.initials: K
authors.lastname: Hyodo
authors.forename: F A
authors.initials: FA
authors.lastname: Dilmanian
authors.forename: Y
authors.initials: Y
authors.lastname: Itai
authors.forename: T
authors.initials: T
authors.lastname: Akatsuka
mesh_terms: D005453:Fluorescence; D006801:Humans; D007455:Iodine / Q000032:analysis*; D011829:Radiation Dosage; D015899:Tomography, Emission-Computed, Single-Photon; D014057:Tomography, X-Ray Computed; D014978:Xenon / Q000032:analysis*
chemical_list: D014978:Xenon; D007455:Iodine