Presence of LH in gonadotropins associated with higher IVF pregnancy rates when basal serum LH is increased.
OBJECTIVE
To determine if pregnancy rates following in vitro fertilization-embryo transfer (IVF-ET) correlate with the presence or not of luteinizing hormone (LH) in the gonadotropins used for stimulation. Furthermore to see if the early follicular phase serum LH level affects pregnancy outcome according to the type of gonadotropins used.


METHODS
The type of gonadotropins were prescribed randomly according to finances and convenience. Serum LH was obtained on day 2 or 3 of the menstrual cycle.


RESULTS
When LH was > the median, significantly higher pregnancy rates were obtained in those treated with the follicle stimulating hormone (FSH)/human menopausal gonadotropin combination. When LH was < or = the median, significantly more oocytes were retrieved with FSH exclusively. No confounding variables were found to explain the data.


CONCLUSIONS
Considering concerns of published studies that LH may have a toxic effect on pregnancy outcome, and if LH is suppressed too low, gonadotropins with exclusive FSH may not stimulate sufficient oocytes, the results were opposite to expectations.
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J H
JH
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center Department of Obstetrics and Gynecology, USA.
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M L
ML
Nazari
P
P
Davies
E
E
Choe
J K
JK
D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro / Q000191:economics / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D005498:Follicular Phase / Q000097:blood / Q000187:drug effects; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage; D007986:Luteinizing Hormone / Q000008:administration & dosage* / Q000097:blood*; D008297:Male; D008596:Menotropins / Q000008:administration & dosage*; D010062:Ovulation Induction / Q000191:economics / Q000379:methods*; D011247:Pregnancy; D018873:Pregnancy Rate
D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide