title: Autonomic insufficiency as a factor contributing to dialysis-induced hypotension.
abstract: BACKGROUND
  Autonomic insufficiency is considered a factor that contributes to dialysis-induced hypotension (DIH). However, the relationship between the two conditions has not been fully elucidated.
  
  
  METHODS
  We investigated 44 haemodialysis patients using [(123)I]-meta-iodobenzylguanidine (MIBG) scintigraphy and power-spectral analysis (PSA) of heart rate variability. The patients were divided into four groups: a diabetic group with DIH, a diabetic group without DIH, a non-diabetic group with DIH, and a non-diabetic group without DIH. In these groups the heart to mediastinum average count rate (H/M), MIBG washout rate, and low- and high-frequency components of PSA were compared.
  
  
  RESULTS
  From the [(123)I]-MIBG scintigraphy, for both early and delayed images, H/M of the groups with DIH were lower than in groups without DIH, in both diabetics and non-diabetics (P<0.05). For the early images, H/M of the diabetic groups were lower than in the non-diabetic groups, in the groups both with and without DIH (P<0.01). For the delayed images, H/M of the diabetic group was lower than in the non-diabetic group, in the groups with DIH (P<0.05). The MIBG washout rate was the highest in the diabetic group with DIH (P<0.05 vs diabetic and non-diabetic groups without DIH). The PSA of heart rate variability showed a good discrimination of the low-frequency component between the non-diabetic patients with and without DIH (P<0.05). Mean ultrafiltration volume and its rate were not different among the four groups.
  
  
  CONCLUSIONS
  Autonomic insufficiency is more severe in patients with DIH than in those without, and its degree may be enhanced in diabetic patients. For the management of DIH, special care should be addressed not only to dry weight but also to autonomic insufficiency.
authors.affiliation: Department of Nephrology, Sendai Shakaihoken Hospital, Sendai, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: I
authors.initials: I
authors.lastname: Horigome
authors.forename: S
authors.initials: S
authors.lastname: Chiba
authors.forename: T
authors.initials: T
authors.lastname: Furuta
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: O
authors.initials: O
authors.lastname: Hotta
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Noshiro
authors.forename: Y
authors.initials: Y
authors.lastname: Taguma
mesh_terms: D019797:3-Iodobenzylguanidine; D000368:Aged; D001341:Autonomic Nervous System / Q000503:physiopathology; D001342:Autonomic Nervous System Diseases / Q000150:complications* / Q000503:physiopathology; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging; D006339:Heart Rate; D006801:Humans; D007022:Hypotension / Q000000981:diagnostic imaging / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D019275:Radiopharmaceuticals; D006435:Renal Dialysis / Q000009:adverse effects*
chemical_list: D019275:Radiopharmaceuticals; D019797:3-Iodobenzylguanidine