beta -Helical polymers from isocyanopeptides.
Polymerization of isocyanopeptides results in the formation of high molecular mass polymers that fold in a proteinlike fashion to give helical strands in which the peptide chains are arranged in beta-sheets. The beta-helical polymers retain their structure in water and unfold in a cooperative process at elevated temperatures. The peptide architecture in these polymers is a different form of the beta-helix motif found in proteins. Unlike their natural counterparts, which contain arrays of large beta-sheets stacked in a helical fashion, the isocyanopeptide polymers have a central helical core that acts as a director for the beta-sheet-like arrangement of the peptide side arms. The helical structure of these isocyanopeptide polymers has the potential to be controlled through tailoring of the side branches and the hydrogen-bonding network present in the beta-sheets.
Cornelissen
J J
JJ
Department of Organic Chemistry, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands.
Donners
J J
JJ
de Gelder
R
R
Graswinckel
W S
WS
Metselaar
G A
GA
Rowan
A E
AE
Sommerdijk
N A
NA
Nolte
R J
RJ
D000409:Alanine / Q000737:chemistry*; D002942:Circular Dichroism; D003486:Cyanides / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D018625:Microscopy, Atomic Force; D008968:Molecular Conformation; D009842:Oligopeptides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D017510:Protein Folding; D017433:Protein Structure, Secondary; D013055:Spectrophotometry, Infrared; D013696:Temperature; D014269:Trifluoroacetic Acid; D014867:Water / Q000737:chemistry
D003486:Cyanides; D009842:Oligopeptides; D010455:Peptides; D011108:Polymers; D014867:Water; D014269:Trifluoroacetic Acid; D000409:Alanine