title: Bone marrow colony-forming unit assay in cats with naturally occurring myelodysplastic syndromes.
abstract: Feline myelodysplastic syndromes (MDS) has been diagnosed in many cats infected with feline leukemia virus, although the pathogenesis of this hematopoietic deficiency has been unclear. In this study, we assayed the bone marrow erythroid colony-forming units (CFU-E) and granulocyte-machrophage CFUs (CFU-GM) to investigate the pathogenesis of feline MDS. The number of CFU-E colonies was decreased in 4 of 7 cats with MDS, and the number of CFU-GM colonies was also decreased in 4 cats. Furthermore, small colonies of CFU-GM were found in all 7 cases. These findings indicated that refractory cytopenia of feline MDS could be caused by abnormal maturation and differentiation of hematopoietic stem cells in bone marrow, as it is in human MDS. The pathogenesis of feline MDS might be similar to that of human MDS.
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Nihon University, Kanagawa.
authors.forename: Naho
authors.initials: N
authors.lastname: Nagashima
authors.affiliation: Laboratory of Veterinary Internal Medicine II, School of Veterinary Medicine, Azabu University, Kanagawa.
authors.forename: Masaharu
authors.initials: M
authors.lastname: Hisasue
authors.affiliation: Department of Laboratory Medicine, Faculty of Medicine, University of Tokyo, Tokyo.
authors.forename: Katsumi
authors.initials: K
authors.lastname: Higashi
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Nihon University, Kanagawa. kano@brs.nihon-u.ac.jp.
authors.forename: Rui
authors.initials: R
authors.lastname: Kano
authors.affiliation: Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, University of Tokyo, Tokyo, Japan.
authors.forename: Hajime
authors.initials: H
authors.lastname: Tsujimoto
authors.affiliation: Department of Pathobiology, School of Veterinary Medicine, Nihon University, Kanagawa.
authors.forename: Atsuhiko
authors.initials: A
authors.lastname: Hasegawa
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells / Q000473:pathology; D002371:Cat Diseases / Q000209:etiology* / Q000473:pathology*; D002415:Cats; D008297:Male; D009190:Myelodysplastic Syndromes / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D023461:Myeloid Progenitor Cells; D014411:Neoplastic Stem Cells / Q000473:pathology*; D014410:Tumor Stem Cell Assay