[Expression of epidermal growth factor receptor (EGFR), platelet growth factor receptor (PGFR) and insulin growth factor-1 receptor (IGF-1R) on lung cancer cell].
OBJECTIVE
To evaluate the expression of growth factor receptors (GFRs) on lung cancer cells and the relation between the expression of GFRs and metastasis of lung cancer.


METHODS
The expression of EGFR, PDGFR and IGF-1R was detected with immunohistochemical method using monoclonal antibodies.


RESULTS
The expression of EGFR, PDGFR and IGF-1R showed higher positive rates in lung cancer cells than those in normal lung tissues, and the expression was increased as the disease was advanced.


CONCLUSIONS
The increased expression of EGFR, PDGFR and IGF-1R is related with the metastasis of lung cancer.
Liu
S
S
Department of Respiration, Jinan General Military Hospital, Jinan 250031.
Zhang
B
B
Zhang
S
S
D000230:Adenocarcinoma / Q000378:metabolism / Q000556:secondary; D018288:Carcinoma, Small Cell / Q000378:metabolism / Q000556:secondary; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000556:secondary; D066246:ErbB Receptors / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism* / Q000473:pathology; D008207:Lymphatic Metastasis; D009367:Neoplasm Staging; D017526:Receptor, IGF Type 1 / Q000378:metabolism*; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism*
D066246:ErbB Receptors; D017526:Receptor, IGF Type 1; D017479:Receptors, Platelet-Derived Growth Factor