[The study on hepatitis G virus infection among patients with liver diseases].
OBJECTIVE
To investigate the hepatitis G virus (HGV) infection among patients with liver diseases.


METHODS
Anti-HGV was detected by ELISA among 154 patients with liver diseases (no history of blood transfusion), 54 of them, HGV RNA was detected by RT-PCR concomitantly. The rates of anti-HGV and HGV RNA were calculated, respectively. The positivity of HGV RNA was taken as diagnostic criteria for HGV infection in different kinds of liver disease.


RESULTS
Of 154 patients with liver diseases, anti-HGV was positive in 31 patients, the detectable rate of anti- HGV was 20.13%. HGV RNA was detected in 13 of 54 patients, the detectable rate was 24.07%. The positive rates of HGV RNA tested in 35 patients with chronic hepatitis and 6 patients with fatty-liver were 20.00% (7/35) and a ratio of 5/6, respectively.


CONCLUSIONS
(1) HGV infection is considerably prevalent among patients with non-transfusion transmitted sporadic hepatitis. (2) HGV is a responsible agent for chronic hepatitis. (3) The clinical significance of detectable HGV RNA in patients with fatty-liver remains for further study.
Zhao
X
X
Department of Infectious Diseases of the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China.
Wang
M
M
Li
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018178:Flaviviridae Infections / Q000276:immunology*; D029407:GB virus C / Q000235:genetics / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood*; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D006801:Humans; D008107:Liver Diseases / Q000821:virology*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood*; D020133:Reverse Transcriptase Polymerase Chain Reaction
D006508:Hepatitis Antibodies; D012367:RNA, Viral