PCI complexes: pretty complex interactions in diverse signaling pathways.
Three protein complexes (the proteasome regulatory lid, the COP9 signalosome and eukaryotic translation initiation factor 3) contain protein subunits with a well defined protein domain, the PCI domain. At least two (the COP9 signalosome and the lid) appear to share a common evolutionary origin. Recent advances in our understanding of the structure and function of the three complexes point to intriguing and unanticipated connections between the cellular functions performed by these three protein assemblies, especially between translation initiation and proteolytic protein degradation.
Kim
T
T
Dept Botany, The University of Tennessee, Knoxville TN 37996-1100, USA.
Hofmann
K
K
von Arnim
A G
AG
Chamovitz
D A
DA
D000818:Animals; D000075686:COP9 Signalosome Complex; D003546:Cysteine Endopeptidases / Q000145:classification / Q000235:genetics*; D039621:Eukaryotic Initiation Factor-3; D019143:Evolution, Molecular; D009097:Multienzyme Complexes / Q000145:classification / Q000235:genetics*; D046912:Multiprotein Complexes; D010447:Peptide Hydrolases; D010448:Peptide Initiation Factors / Q000145:classification / Q000235:genetics*; D010802:Phylogeny; D046988:Proteasome Endopeptidase Complex; D014176:Protein Biosynthesis; D011506:Proteins / Q000145:classification / Q000235:genetics*; D015398:Signal Transduction
D039621:Eukaryotic Initiation Factor-3; D009097:Multienzyme Complexes; D046912:Multiprotein Complexes; D010448:Peptide Initiation Factors; D011506:Proteins; D010447:Peptide Hydrolases; D000075686:COP9 Signalosome Complex; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex