Journey of the iodide transporter NIS: from its molecular identification to its clinical role in cancer.
The Na+/I- symporter (NIS) is an intrinsic plasma membrane protein that mediates the active transport of I- in the thyroid, lactating mammary gland, stomach and salivary glands. The presence of NIS in the thyroid is exploited in diagnostic scintigraphic imaging and radioiodide therapy in thyroid cancer. The continued rapid progress in NIS research (aimed at the elucidation of the Na+-dependent I- transport mechanism, the analysis of NIS structure-function relations and the study of the tissue-specific regulation of NIS at all levels), holds potentially far-reaching medical applications beyond thyroid disease, in breast cancer and malignancies in other tissues.
Riedel
C
C
Albert Einstein College of Medicine, Dept of Molecular Pharmacology, 1300 Morris Park Ave., Bronx, NY 10461, USA.
Dohán
O
O
De la Vieja
A
A
Ginter
C S
CS
Carrasco
N
N
D000818:Animals; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation; D015316:Genetic Therapy; D007455:Iodine / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000503:physiopathology* / Q000628:therapy; D027981:Symporters; D013961:Thyroid Gland / Q000378:metabolism; D000099209:Sodium-Iodide Symporters
D002352:Carrier Proteins; D007455:Iodine; D008565:Membrane Proteins; D027981:Symporters; D000099209:Sodium-Iodide Symporters