title: Water soluble polymers in tumor targeted delivery.
abstract: The rationales for the use of water soluble polymers for anticancer drug delivery include: the potential to overcome some forms of multidrug resistance, preferential accumulation in solid tumors due to enhanced permeability and retention (EPR) effect, biorecognizability, and targetability. The utility of a novel paradigm for the treatment of ovarian carcinoma in an experimental animal model, which combines chemotherapy and photodynamic therapy with polymer-bound anticancer drugs is explained. Research and clinical applications as well as directions for the future development of macromolecular therapeutics are discussed.
authors.affiliation: Department of Pharmaceutics and Pharmaceutical Chemistry, University of Utah, 30 South 2000 East, Room 301, Salt Lake City, UT 84112, USA. jindrich.kopecek@m.cc.utah.edu
authors.forename: J
authors.initials: J
authors.lastname: Kopecek
authors.forename: P
authors.initials: P
authors.lastname: Kopecková
authors.forename: T
authors.initials: T
authors.lastname: Minko
authors.forename: Z R
authors.initials: ZR
authors.lastname: Lu
authors.forename: C M
authors.initials: CM
authors.lastname: Peterson
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D016503:Drug Delivery Systems; D005260:Female; D006492:Hempa; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000188:drug therapy
chemical_list: D000970:Antineoplastic Agents; D006492:Hempa