The role of intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and regulated on activation, normal T-cell expressed and secreted (RANTES) in the relationship between air pollution and asthma among children.
To evaluate the role of adhesion molecules and chemokines in the relationship between air pollution and asthma, the authors determined the following in 230 children who lived in 4 communities in Japan that had different levels of air pollution: serum concentrations of soluble intercellular adhesion molecule-1 (sICAM-1); soluble vascular cell adhesion molecule-1 (sVCAM-1); regulated on activation, normal T-cell expressed and secreted (RANTES); and total immunoglobulin E (IgE). Children with asthma or who exhibited wheezing (n = 115) and nonasthmatic children (n = 115) were studied. Serum concentrations of sICAM-1, sVCAM-1, and RANTES were increased significantly in asthmatic children, compared with nonasthmatic children. Nonasthmatic children with serum IgE levels that were greater than or equal to 250 IU/ml had significantly lower concentrations of sICAM-1 and sVCAM-1 than the other children. The geometric means of sICAM-1 increased as air pollution increased. The results of this study suggest that adhesion molecules or chemokines are associated with asthma and that ICAM-1 may play an important role in the relationship between air pollution and the occurrence of asthma.
Ando
M
M
Department of Public Health, Chiba University School of Medicine, Japan.
Shima
M
M
Adachi
M
M
Tsunetoshi
Y
Y
D000393:Air Pollutants / Q000032:analysis; D000397:Air Pollution / Q000009:adverse effects*; D001249:Asthma / Q000097:blood / Q000453:epidemiology* / Q000209:etiology* / Q000276:immunology; D016022:Case-Control Studies; D018946:Chemokine CCL5 / Q000097:blood*; D002648:Child; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000097:blood*; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007564:Japan / Q000453:epidemiology; D008297:Male; D009585:Nitrogen Dioxide / Q000032:analysis; D010316:Particle Size; D019010:Vascular Cell Adhesion Molecule-1 / Q000097:blood*
D000393:Air Pollutants; D018946:Chemokine CCL5; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1; D007073:Immunoglobulin E; D009585:Nitrogen Dioxide