Neural cell adhesion molecule and neurothelin expression in human ameloblastoma.
OBJECTIVE
The objective of the present study was to determine whether neural cell adhesion molecules (NCAM; CD56) and neurothelin (CD147) are expressed by adontogenic cells in the ameloblastoma.


METHODS
Frozen sections from ameloblastoma specimens (n = 7) were stained with monoclonal antibody-recognizing CD56 and CD147 molecules using indirect immunoperoxidase and indirect immunofluorescent techniques.


RESULTS
CD56 and CD147 molecules were strongly expressed by the peripheral columnar cells of the tumor nests. Neurothelin reactivity was also present in the stellate reticulum of the nests and in some stromal components.


CONCLUSIONS
The presence of these antigens in ameloblastoma supports the classic view about the neural crest origin of cells giving use to this tumor.
Er
N
N
Received from the University of Hacettepe, Ankara, Turkey. nuer@hacettepe.edu.tr
Dağdeviren
A
A
Taşman
F
F
Zeybek
D
D
D000564:Ameloblastoma / Q000473:pathology*; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface / Q000032:analysis*; D030161:Avian Proteins; D051926:Basigin; D001798:Blood Proteins; D004396:Coloring Agents; D016650:Fluorescein-5-isothiocyanate; D019084:Fluorescent Antibody Technique, Indirect; D005456:Fluorescent Dyes; D006416:Hematoxylin; D006801:Humans; D007124:Immunoenzyme Techniques; D007573:Jaw Neoplasms / Q000473:pathology; D008562:Membrane Glycoproteins / Q000032:analysis*; D008856:Microscopy, Fluorescence; D019006:Neural Cell Adhesion Molecules / Q000032:analysis*; D009432:Neural Crest / Q000473:pathology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; C497886:BSG protein, human; D001798:Blood Proteins; C102624:Bsg protein, Gallus gallus; C079432:Bsg protein, rat; D004396:Coloring Agents; D005456:Fluorescent Dyes; D008562:Membrane Glycoproteins; D019006:Neural Cell Adhesion Molecules; D051926:Basigin; D016650:Fluorescein-5-isothiocyanate; D006416:Hematoxylin