title: Acute loss of capture due to flecainide acetate.
abstract: Antiarrhythmic drugs increase pacing threshold, but this is rarely of clinical significance. Administration of flecainide acetate in a 75-year-old woman with an implanted AAIR pacemaker because of sick sinus syndrome caused an abrupt rise of pacing threshold and failure of pacing. Pacing threshold returned to the normal value a few days after flecainide treatment was stopped.
authors.affiliation: Dept. of Cardiology, Ha'Emek Medical Center, 18101 Afula, Israel. antonelli_dante@hotmail.com
authors.forename: D
authors.initials: D
authors.lastname: Antonelli
authors.forename: N A
authors.initials: NA
authors.lastname: Freedberg
authors.forename: T
authors.initials: T
authors.lastname: Rosenfeld
mesh_terms: D000208:Acute Disease; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000009:adverse effects*; D005260:Female; D005424:Flecainide / Q000009:adverse effects*; D006801:Humans; D010138:Pacemaker, Artificial; D011475:Prosthesis Failure
chemical_list: D000889:Anti-Arrhythmia Agents; D005424:Flecainide