title: Screening with breast ultrasound in a population at moderate risk due to family history.
abstract: OBJECTIVE
  To perform a pilot study to compare ultrasound and mammographic screening with particular respect to specificity, in a cohort of women at moderate family history risk of breast cancer.
  
  
  METHODS
  High resolution ultrasound of both breasts was undertaken in 149 women at moderate risk of breast cancer who were referred for mammographic screening. The two tests were read blind to the other. Core biopsy was undertaken for solid lesions found on ultrasound.
  
  
  RESULTS
  149 Patients, mean age 42.15 years, were screened with bilateral ultrasound. 90 Examinations were normal. 46 Women had cysts, two had lesions previously biopsied and found to be benign, and one had a lymph node. 10 Focal solid lesions were biopsied on account of their ultrasound findings, 6.7% (95% confidence intervals (95% CIs) 2.7% to 10.7%). All but one of the 149 mammograms were normal. In this case both mammography and ultrasound showed a focal solid lesion that at core biopsy was found to be a fibroadenoma. Histology showed seven fibroadenomata, two areas of fibrocystic change, and one adenoid cystic carcinoma. Positive predictive value for biopsy was 10%. Mean follow up was 13.7 months. There was one interval cancer.
  
  
  CONCLUSIONS
  Screening with breast ultrasound, in a cohort of women at moderate risk of breast cancer due to family history, has an acceptable biopsy rate. Screening with ultrasound and mammography in patients with an increased risk of breast cancer may be beneficial and a randomised study to examine issues of acceptability, reproducibility, and cost effectiveness is apt.
authors.affiliation: Cambridge Breast Unit, Addenbrooke's Hospital, UK. donald.o'driscoll@ipsh-tr.anglox.nhs.uk
authors.forename: D
authors.initials: D
authors.lastname: O'Driscoll
authors.forename: R
authors.initials: R
authors.lastname: Warren
authors.forename: J
authors.initials: J
authors.lastname: MacKay
authors.forename: P
authors.initials: P
authors.lastname: Britton
authors.forename: N E
authors.initials: NE
authors.lastname: Day
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy / Q000379:methods; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000235:genetics / Q000473:pathology; D005260:Female; D006801:Humans; D008403:Mass Screening; D008875:Middle Aged; D010375:Pedigree; D010865:Pilot Projects; D012307:Risk Factors; D016217:Ultrasonography, Mammary