Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells.
Vitale
M
M
Institute of Human Anatomy, University of Parma, Ospedale Maggiore, 14 43100 Parma, Italy.
Matteucci
A
A
Manzoli
L
L
Rodella
L
L
Mariani
A R
AR
Zauli
G
G
Falconi
M
M
Billi
A M
AM
Martelli
A M
AM
Gilmour
R S
RS
Cocco
L
L
D002455:Cell Division; D002467:Cell Nucleus / Q000201:enzymology*; D004789:Enzyme Activation; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D007376:Interleukin-2 / Q000494:pharmacology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007694:Killer Cells, Natural / Q000201:enzymology* / Q000648:ultrastructure; D019950:Mitogen-Activated Protein Kinase 1 / Q000378:metabolism; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D054799:Phospholipase C beta; D010766:Phosphorylation; D010768:Phosphoserine / Q000378:metabolism; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors / Q000378:metabolism*
D004791:Enzyme Inhibitors; D007376:Interleukin-2; D007527:Isoenzymes; D010768:Phosphoserine; D019950:Mitogen-Activated Protein Kinase 1; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases; D010738:Type C Phospholipases; D054799:Phospholipase C beta