title: The formulation of an effective topical antibacterial product containing Ocimum gratissimum leaf essential oil.
abstract: The antibacterial potential of Ocimum gratissimum essential oil was explored. Liquid and semisolid formulations of the oil were designed in a variety of bases for topical antiseptic medication. The products were evaluated by agar diffusion assay against type strains and clinical isolates from boil, wound and pimples. Remarkable antibacterial effects, higher than those of commercial antiseptic products, were demonstrated at 2% Ocimum oil concentration in some bases. The properties of base into which the oil was incorporated affected its activity. It was more effective in hydrophilic bases than in lipophilic bases. Solubilization and microemulsification grossly reduced its activity.
authors.affiliation: Department of Pharmaceutics, Obafemi Awolowo University, Ile-Ife, Nigeria.
authors.forename: L O
authors.initials: LO
authors.lastname: Orafidiya
authors.forename: A O
authors.initials: AO
authors.lastname: Oyedele
authors.forename: A O
authors.initials: AO
authors.lastname: Shittu
authors.forename: A A
authors.initials: AA
authors.lastname: Elujoba
mesh_terms: D000891:Anti-Infective Agents, Local / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D005079:Excipients; D006801:Humans; D008826:Microbial Sensitivity Tests; D018649:Ocimum basilicum / Q000737:chemistry*; D009824:Ointments; D018515:Plant Leaves / Q000737:chemistry; D010938:Plant Oils / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry; D011511:Proteus / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012996:Solutions / Q000737:chemistry; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D000891:Anti-Infective Agents, Local; D005079:Excipients; D009824:Ointments; D010938:Plant Oils; D012996:Solutions; C080118:ocimum oil