Evolution of a synthetic approach to CP-263,114.
[structure: see text] Three different approaches to the carbocyclic core of CP-263,114 are presented that illustrate a strategic evolution from an oxy-Cope rearrangement to variants of the Wharton fragmentation.
Njardarson
J T
JT
Sterling Chemistry Laboratory, Department of Chemistry, Yale University, New Haven, Connecticut 06520-8107, USA.
Wood
J L
JL
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004791:Enzyme Inhibitors / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D008299:Maleic Anhydrides / Q000138:chemical synthesis*; D013237:Stereoisomerism
C104957:CP 263114; D004791:Enzyme Inhibitors; D007202:Indicators and Reagents; D008299:Maleic Anhydrides