title: Early histological changes of ileal mucosa after augmentation cystoplasty.
abstract: Segments of bowel are used routinely for transplantation in various pathological conditions such as contracted bladders or poorly compliant neuropathic bladders. However, little is known how these intestinal segments adopt to a toxic environment caused by urine. Therefore, the present study was performed to determine early histological changes of ileal mucosa after augmentation cystoplasty. Seven patients with augmentation cystoplasty underwent random cold-cup biopsies of ileal segments after a mean period of 14.4 months after cystoplasty and morphological changes were evaluated using light microscopy and transmission and scanning electron microscopy. Most pronounced features were varying degrees of villous atrophy, increased numbers of Paneth and goblet cells. Severity of atrophic villous changes were not related to the length of the interval between surgery and endoscopic biopsy. These findings may be explained as adaptations of bowel tissue to counteract noxious effects of urine and to maintain its epithelial function in the bladder.
authors.affiliation: Department of Histology and Embryology, School of Medicine, Marmara University, Istanbul, Turkey. sulecet@superonline.com
authors.forename: S
authors.initials: S
authors.lastname: Cetinel
authors.forename: T
authors.initials: T
authors.lastname: San
authors.forename: B
authors.initials: B
authors.lastname: Cetinel
authors.forename: N
authors.initials: N
authors.lastname: Uygun
authors.forename: C
authors.initials: C
authors.lastname: Hürdağ
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D007082:Ileum / Q000637:transplantation* / Q000648:ultrastructure; D007413:Intestinal Mucosa / Q000473:pathology / Q000637:transplantation* / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous; D001743:Urinary Bladder / Q000601:surgery*; D001750:Urinary Bladder, Neurogenic / Q000601:surgery; D013520:Urologic Surgical Procedures