[Repair of rabbit auricular defects using chondrocyte-scaffolding constructs].
OBJECTIVE
To evaluate if the tissue-engineered cartilage can repair the auricular defects in rabbits that have inherent immunity.


METHODS
Rabbit auricular defects were repaired using chondrocyte-PGA constructs cultured in vitro. The gross and histological comparisons were made between the experimental and the control groups.


RESULTS
The rabbit auricular defects were repaired with chondrocyte-PGA constructs, leaving fibroid tissue in the interface between the tissue-engineered cartilage and the normal cartilage.


CONCLUSIONS
The auricular defects can be repaired by chondrocyte-PGA in vitro cultured constructs in animals like rabbits that have acquired immunity. The interface healing problems need further study.
Liu
Y
Y
Department of Plastic Surgery, Ninth People's Hospital of Shanghai, Shanghai Second Medical University, Shanghai 200011.
Wang
W
W
Cao
Y
Y
D000818:Animals; D002478:Cells, Cultured; D019902:Chondrocytes / Q000166:cytology / Q000637:transplantation*; D018920:Coculture Techniques; D004425:Ear Cartilage / Q000166:cytology / Q000601:surgery*; D004431:Ear, External / Q000601:surgery*; D005260:Female; D008297:Male; D011100:Polyglycolic Acid; D011817:Rabbits; D011897:Random Allocation; D016378:Tissue Transplantation / Q000379:methods
D011100:Polyglycolic Acid