A new titanium fiber mesh-cuffed peritoneal dialysis catheter: evaluation and comparison with a Dacron-cuffed tenckhoff catheter in goats.
OBJECTIVE
We report the development of a new peritoneal dialysis catheter. The purpose of the current study was to evaluate tissue response to this catheter.


METHODS
In our catheter design, the catheter's cuffs are made from sintered titanium fiber mesh instead of the common Dacron material. The catheters were implanted in goats. During the study period, the catheter exit sites were observed once every 2 weeks. After 14 weeks, the catheters and surrounding tissues were processed for histology and analyzed.


RESULTS
We observed that catheters with titanium cuffs performed significantly better, compared with a commercial catheter design. Histology showed that titanium fibers evoked a lesser inflammatory response compared with Dacron fibers. In addition, the capsule surrounding the titanium cuff was significantly thinner.


CONCLUSIONS
Supported by the obtained results, we conclude that the use of Dacron velour for anchorage of percutaneous catheters has to be reconsidered. Titanium fiber mesh has a great potential for application in percutaneous catheters.
Walboomers
F
F
Department of Biomaterials, College of Dental Science, University Medical Center, Nijmegen, The Netherlands.
Paquay
Y C
YC
Jansen
J A
JA
D000818:Animals; D002404:Catheterization; D004867:Equipment Design; D006041:Goats; D010530:Peritoneal Dialysis / Q000295:instrumentation*; D010537:Peritoneum / Q000473:pathology; D011093:Polyethylene Terephthalates; D014025:Titanium
D011093:Polyethylene Terephthalates; D014025:Titanium