title: Isolated Pneumocystis carinii infection of adrenal glands causing Addison's disease in a non-immunocompromised adult.
abstract: Pneumocystis carinii is primarily an opportunistic pathogen infecting patients with AIDS and other immunocompromised patients, and ordinarily does not affect immunocompetent persons. We report isolated P. carinii infection of bilateral adrenal glands in a non-immunocompromised adult male, leading to fatal Addisonian crisis. Diagnosis of P. carinii was established on the basis of cytopathology and microbiological tests, using conventional staining techniques and direct immunofluorescence on ultrasound-guided fine needle aspirates and trucut needle biopsy specimen from adrenal glands. P. carinii pneumonia and other fungal infections of the adrenal glands were excluded by appropriate tests. Absence of HIV infection was established by negative ELISA for HIV I and II antibodies and Western blot analysis at the time of presentation and 45 d later. Normal blood total leukocyte and CD4 lymphocyte counts and IgG and IgA levels confirmed the immunocompetent status of the patient. The patient improved with anti-Pneumocystis treatment and corticosteroid replacement, but succumbed to an episode of Addisonian crisis triggered by a diarrheal illness.
authors.affiliation: Department of Microbiology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Raebareli Road, Lucknow-226 014, India.
authors.forename: J
authors.initials: J
authors.lastname: Agarwal
authors.forename: G
authors.initials: G
authors.lastname: Agarwal
authors.forename: A
authors.initials: A
authors.lastname: Ayyagari
authors.forename: D K
authors.initials: DK
authors.lastname: Kar
authors.forename: S K
authors.initials: SK
authors.lastname: Mishra
authors.forename: E
authors.initials: E
authors.lastname: Bhatia
mesh_terms: D000224:Addison Disease / Q000382:microbiology* / Q000473:pathology; D000311:Adrenal Glands / Q000382:microbiology* / Q000473:pathology; D000946:Antigens, Fungal / Q000032:analysis; D017809:Fatal Outcome; D019085:Fluorescent Antibody Technique, Direct; D006801:Humans; D008297:Male; D008875:Middle Aged; D011010:Pneumocystis / Q000302:isolation & purification*; D016720:Pneumocystis Infections / Q000382:microbiology* / Q000473:pathology; D014057:Tomography, X-Ray Computed
chemical_list: D000946:Antigens, Fungal