title: Role of endogenous interleukin-12 in immune response to staphylococcal enterotoxin B in mice.
abstract: In the present study, the roles of interleukin 12 (IL-12) and IL-18 and their possible interaction during superantigen-induced responses were studied by injection of staphylococcal enterotoxin B (SEB) into mice. These data suggest that the role of IL-12 in SEB-induced responses is limited to sustaining gamma interferon release by an IL-18-independent mechanism.
authors.affiliation: Laboratory of Experimental Internal Medicine, University of Amsterdam, Amsterdam, The Netherlands.
authors.forename: F N
authors.initials: FN
authors.lastname: Lauw
authors.forename: S
authors.initials: S
authors.lastname: Florquin
authors.forename: P
authors.initials: P
authors.lastname: Speelman
authors.forename: S J
authors.initials: SJ
authors.lastname: van Deventer
authors.forename: T
authors.initials: T
authors.lastname: van der Poll
mesh_terms: D000818:Animals; D004768:Enterotoxins / Q000008:administration & dosage* / Q000276:immunology*; D018664:Interleukin-12 / Q000378:metabolism*; D020382:Interleukin-18 / Q000378:metabolism; D051379:Mice; D013154:Spleen / Q000276:immunology; D013211:Staphylococcus aureus / Q000378:metabolism*; D018089:Superantigens / Q000008:administration & dosage / Q000276:immunology
chemical_list: D004768:Enterotoxins; D020382:Interleukin-18; D018089:Superantigens; D018664:Interleukin-12; C031818:enterotoxin B, staphylococcal