title: [The protective effects of prompt escharectomy on myocardial injury following burn in rats].
abstract: OBJECTIVE
  To investigate the protective effects of prompt escharectomy on myocardial injury following severe burns.
  
  
  METHODS
  Rats were inflicted with 30% TBSA III degree scald. They were randomly divided into 3 groups: control group (C, n = 10), non-escharectomy group (NE, n = 50), escharectomy group (E, n = 50). In the E group, burn wounds were excised promptly after the injury. The levels of troponin T (TnT) and tumor necrosis factor (TNF) in plasma and TNF in myocardium were measured at 1, 3, 6, 12 and 24 hours postburn.
  
  
  RESULTS
  TnT levels increased markedly at 3 hours post burn, plasma TNF levels increased markedly at 6 hours postburn, and TNF levels in myocardium also increased markedly at 12 hours postburn compared with the C group. Although the levels of TnT and TNF were a little lower in NE group than those in E group at 3 hours post burn, the levels of TnT 6 hours postburn and levels of TNF 12 hours postburn were significantly higher in NE group than those in E group. There were good positive correlations between TNF with TnT levels.
  
  
  CONCLUSIONS
  TNF played important roles in the pathogenesis of myocardial injury following burns, its level was correlated with the severity of myocardial injury. TNF levels in E group was much lower that in NE group, suggesting that prompt escharectomy could reduce the production and release of inflammatory cytokines, and lessen the myocardial injury induced by uncontrolled inflammatory response.
authors.affiliation: Institute of Burn Research, Southwestern Hospital, Third Military Medical University, Changqing, 400038.
authors.forename: B
authors.initials: B
authors.lastname: Yan
authors.forename: Y
authors.initials: Y
authors.lastname: Huang
authors.forename: Z
authors.initials: Z
authors.lastname: Yang
mesh_terms: D000818:Animals; D002056:Burns / Q000150:complications / Q000601:surgery*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D020107:Troponin T / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D020107:Troponin T; D014409:Tumor Necrosis Factor-alpha