Seven new sesquiterpene glycosides from the root bark of Dictamnus dasycarpus.
From the water-soluble constituents of the root bark of Dictamnus dasycarpus, six new eudesmane-type sesquiterpene glycosides, dictamnosides H-M (1-6), and a new trinorguaiane-type sesquiterpene glycoside, dictamnoside N (7), together with four known sesquiterpene glycosides, dictamnosides A (8), B (9), D (10), and G (11), were isolated. Their structures were elucidated by spectroscopic analyses and chemical evidence. In vitro tests for immunological activity showed dictamnoside A (8) to possess remarkable activity in stimulating the proliferation of T-cells.
Chang
J
J
Shanghai Institute of Materia Medica, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 294 Taiyuan Road, Shanghai 200031, People's Republic of China.
Xuan
L J
LJ
Xu
Y M
YM
Zhang
J S
JS
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D015394:Molecular Structure; D018517:Plant Roots / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology / Q000378:metabolism
D004365:Drugs, Chinese Herbal; D006027:Glycosides; D012717:Sesquiterpenes