title: Platelet-derived growth factor and transforming growth factor-beta in invertebrate immune and neuroendocrine interactions: another sign of conservation in evolution.
abstract: Growth factor-like molecules have been found in various invertebrate species. In particular, we have reported the presence of platelet-derived growth factor (PDGF)-AB and transforming growth factor-beta (TGF-beta)1 immunoreactive molecules in molluscs, insects and annelids. Moreover, PDGF-AB and TGF-beta1 affect the main immune functions, such as phagocytosis, chemotaxis and cell motility. Changes in cell shape are induced via interactions of growth factors with their respective specific receptors. The extracellular signals are transduced by the activation of classical signal transduction pathways, such as those involving PKA and PKC, and pivotal transcription regulators, i.e. the Fos, Jun and SMAD proteins. The two growth factors intervene in stress responses by activating the CRH-ACTH-biogenic amine axis. Exogenous administration of PDGF-AB and TGF-beta1 in a molluscan wound provokes an accelerated migration of immunocytes and fibroblasts to the injured area, stimulating granulation tissue formation and wound re-epithelialization. These findings suggest that these molecules are ancestral and that their function is well conserved and crucial in the maintenance of invertebrate homeostasis.
authors.affiliation: Department of Animal Biology, University of Modena and Reggio Emilia, via Campi 213/D, 41100, Modena, Italy. ottaviani.enzo@unimo.it
authors.forename: E
authors.initials: E
authors.lastname: Ottaviani
authors.forename: A
authors.initials: A
authors.lastname: Franchini
authors.forename: D
authors.initials: D
authors.lastname: Kletsas
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002465:Cell Movement; D002633:Chemotaxis; D006706:Homeostasis; D007107:Immune System / Q000502:physiology*; D007448:Invertebrates / Q000502:physiology*; D009490:Neurosecretory Systems / Q000502:physiology*; D010587:Phagocytosis; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000494:pharmacology*; D014945:Wound Healing / Q000502:physiology*
chemical_list: D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta