[Clinical study of purified xuefu capsule in treating angina pectoris].
OBJECTIVE
To study the effect of purified Xuefu Capsule (PXFC) in treating angina pectoris (AP).


METHODS
Fifty-seven patients with AP were randomly divided into two groups. Group A (30 cases) was treated with PXFC and western medicine, and group B(27 cases) with western medicine (isosorbide dinitrate, diltiazem or atenolol) alone.


RESULTS
The total effective rates and ECG ST-T changes of AP were 93.3% and 63.3% respectively in group A. These results were all superior to those of group B (P < 0.05). Moreover, in group A the level of plasma endothelin (ET-1) decreased from 85.09 +/- 37.56 ng/L to 61.19 +/- 4.02 ng/L, and that of calcitonin gene related peptide (CGRP) increased from 58.64 +/- 19.30 ng/L to 88.87 +/- 20.41 ng/L. Comparing with group B, these changes were statistically different (P < 0.01).


CONCLUSIONS
The effects of adding PXFC on conventional treatment with western medicine were better than those of western medicine.
Wang
X
X
Xiyuan Hospital, China Academy of TCM, Beijing 100091.
Chen
K
K
Wang
W
W
D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000188:drug therapy*; D015740:Calcitonin Gene-Related Peptide / Q000097:blood; D002214:Capsules; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D019332:Endothelin-1 / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D016037:Single-Blind Method
D002214:Capsules; D004365:Drugs, Chinese Herbal; D019332:Endothelin-1; D009543:Nifedipine; D015740:Calcitonin Gene-Related Peptide