An alternatively spliced long form of Fas apoptosis inhibitory molecule (FAIM) with tissue-specific expression in the brain.
The gene encoding Fas apoptosis inhibitory molecule (FAIM) was cloned by differential display using RNA obtained from Fas-resistant and Fas-sensitive primary murine B lymphocytes. FAIM is highly evolutionarily conserved and broadly expressed, suggesting that its gene product plays a key role in cellular physiology. Here we report the identification of a new, longer form of FAIM (FAIM-L) and characterization of the genomic locus that clarifies its origin. The murine FAIM gene is located at chromosome 9f1, a region syntenic to the corresponding location of the human FAIM gene. The gene consists of six exons and contains putative translation initiation sites within exons II and III. The long form of FAIM is generated by all six exons, whereas the originally cloned form of FAIM, now termed FAIM-Short (FAIM-S) is generated from five exons by alternative splicing. FAIM-L is dominantly expressed in the brain whereas FAIM-S is widely expressed in many tissues.
Zhong
X
X
Department of Pathology, Boston University School of Medicine, 80 East Concord Street, Boston, MA 02118, USA.
Schneider
T J
TJ
Cabral
D S
DS
Donohoe
T J
TJ
Rothstein
T L
TL
D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D051017:Apoptosis Regulatory Proteins; D001921:Brain / Q000378:metabolism*; D002874:Chromosome Mapping; D015870:Gene Expression; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D020033:Protein Isoforms / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D019014:fas Receptor
D051017:Apoptosis Regulatory Proteins; C421307:FAIM protein, human; C498892:Faim protein, mouse; D020033:Protein Isoforms; D011506:Proteins; D019014:fas Receptor