title: Metalloprotein and redox protein design.
abstract: Metalloprotein and redox protein design are rapidly advancing toward the chemical synthesis of novel proteins that have predictable structures and functions. Current data demonstrate a breadth of successful approaches to metallopeptide and metalloprotein design based on de novo, rational and combinatorial strategies. These sophisticated synthetic analogs of natural proteins constructively test our comprehension of metalloprotein structure/function relationships. Additionally, designed redox proteins provide novel constructs for examining the thermodynamics and kinetics of biological electron transfer.
authors.affiliation: Department of Chemistry, MC 3121, Columbia University, New York, NY 10027, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Kennedy
authors.forename: B R
authors.initials: BR
authors.lastname: Gibney
mesh_terms: D000465:Algorithms; D003545:Cysteine / Q000032:analysis; D006420:Hemeproteins / Q000378:metabolism; D008024:Ligands; D008667:Metalloproteins / Q000737:chemistry*; D008958:Models, Molecular; D010084:Oxidation-Reduction; D015202:Protein Engineering; D017299:Rod Opsins / Q000138:chemical synthesis; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D006420:Hemeproteins; D008024:Ligands; D008667:Metalloproteins; D017299:Rod Opsins; C118236:dg1 protein, Phelsuma madagascariensis longintinue; D013482:Superoxide Dismutase; D003545:Cysteine