title: Antimicrobial activity of Argentine plants used in the treatment of infectious diseases. Isolation of active compounds from Sebastiania brasiliensis.
abstract: Different extracts of Sebastiania brasiliensis, Sebastiania klotszchiana, Polygonum punctatum, Lithraea molleoides and Myrcianthes cisplatensis, all plants growing in Entre Ríos Province and traditionally used as antiseptics, were tested against a set of Gram positive and Gram negative bacteria and fungi. All the species, with the exception of M. cisplatensis, presented activity against some of the microorganisms tested. A 50% hydroalcoholic extract of S. brasiliensis was selected for bioguided fractionation. Two antimicrobial compounds identified as methylgallate (MIC 128 microg/ml) and protocatechuic acid (MIC 128 microg/ml) were isolated apart from quercetin, kaempferol, quercitrin and gallic acid.
authors.affiliation: Cátedra de Microbiología, Facultad de Farmacia y Bioquímica, Universidad de Buenos Aires, Junín 956 (1113), Buenos Aires, Argentina.
authors.forename: C
authors.initials: C
authors.lastname: Penna
authors.forename: S
authors.initials: S
authors.lastname: Marino
authors.forename: E
authors.initials: E
authors.lastname: Vivot
authors.forename: M C
authors.initials: MC
authors.lastname: Cruañes
authors.forename: J
authors.initials: J
authors.lastname: de D  Muñoz
authors.forename: J
authors.initials: J
authors.lastname: Cruañes
authors.forename: G
authors.initials: G
authors.lastname: Ferraro
authors.forename: G
authors.initials: G
authors.lastname: Gutkind
authors.forename: V
authors.initials: V
authors.lastname: Martino
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology; D001118:Argentina; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D019684:Magnoliopsida / Q000737:chemistry*; D008826:Microbial Sensitivity Tests; D008517:Phytotherapy; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010936:Plant Extracts