[Differential diagnostic and prognostic value of serum cytokines (soluble CD30, soluble interleukin-2 receptor, interleukin-10 and interleukin-6) in Hodgkin's disease and lymphosarcomas].
OBJECTIVE
Determination of the importance of serum cytokines (sCD30, sIL-2R, IL-10, IL-6) for diagnosis, response to chemotherapy and remission in patients with lymphogranulomatosis and lymphosarcoma.


METHODS
Cytokine concentrations were measured in 87 samples of serum (plasma) from 54 patients by ELISA. Diagnosis of Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL) was made histologically in 24 and 30 patients, respectively.


RESULTS
The threshold concentrations of sCD30 (and less specific sIL-2R) for HD and NHL patients allowed to estimate sensitivity to chemotherapy after the second course. The threshold concentration of IL-10 can distinguish HD from NHL. Changes in IL-6 concentrations were nonspecific.


CONCLUSIONS
On the basis of the threshold concentrations of sCD30 and IL-10 we offer the scheme of lymphoma diagnosis and prediction of the disease sensitivity to chemotherapy which reduce the duration of lymphoma restaging.
Iaguzhinskaia
O E
OE
Lazarev
I E
IE
Nikitin
E A
EA
Samoĭlova
R S
RS
Loginova
I V
IV
Gemdzhan
E G
EG
Novikov
V A
VA
Mamiliaeva
Z Kh
ZKh
Pivnik
A V
AV
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D016207:Cytokines / Q000097:blood*; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D016753:Interleukin-10 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D017730:Ki-1 Antigen / Q000097:blood; D008228:Lymphoma, Non-Hodgkin / Q000097:blood / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D015375:Receptors, Interleukin-2 / Q000097:blood
D015415:Biomarkers; D016207:Cytokines; D015850:Interleukin-6; D017730:Ki-1 Antigen; D015375:Receptors, Interleukin-2; D016753:Interleukin-10