Taurine has a protective effect against thioacetamide-induced liver cirrhosis by decreasing oxidative stress.
Thioacetamide (TAA) administration (0.3 g/l of tap water for a period of 3 months) to rats resulted in hepatic cirrhosis as assessed by biochemical and histopathological findings. This treatment caused an increase in the levels of malondialdehyde (MDA) and diene conjugates (DCs) and a decrease in the levels of glutathione (GSH), vitamin E, vitamin C and the activities of glutathione peroxidase (GSH-Px) in the liver of rats. Superoxide dismutase (SOD) activities were unchanged. Taurine (2% w/w, added to the chow diet) was administered together with TAA (0.3 g/l of drinking water) for 3 months. Taurine was found to decrease TAA-induced hepatic lipid peroxidation and to increase TAA-depleted vitamin E levels and GSH-Px activities. Histopathological findings also suggested that taurine has an inhibitive effect on TAA-induced hepatic cirrhosis. These results indicate that taurine treatment has a protective effect against TAA-induced liver cirrhosis by decreasing oxidative stress.
Balkan
J
J
Department of Biochemistry, Istanbul Medical Faculty, University of Istanbul, Capa, Turkey.
Doğru-Abbasoğlu
S
S
Kanbağli
O
O
Cevikbaş
U
U
Aykaç-Toker
G
G
Uysal
M
M
D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000009:adverse effects*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008103:Liver Cirrhosis / Q000139:chemically induced* / Q000517:prevention & control* / Q000662:veterinary; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D018384:Oxidative Stress / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism; D013654:Taurine / Q000494:pharmacology*; D013853:Thioacetamide / Q000009:adverse effects*
D002273:Carcinogens; D013853:Thioacetamide; D013654:Taurine; D008315:Malondialdehyde; D013482:Superoxide Dismutase; D005978:Glutathione