title: Motor fluctuations and dyskinesia in Parkinson's disease.
abstract: Motor fluctuations and dyskinesia are common complications of long-term levodopa therapy. The neural and molecular mechanisms underlying their development are partially understood. A variety of clinical strategies may reduce the unpredictability of motor fluctuations and reduce their impact. Prevention of these complications remains an elusive goal.
authors.affiliation: Department of Neurology, School of Medicine, Oregon Health Sciences University, Portland, OR 97201-3098, USA. nuttj@ohsu.edu
authors.forename: J G
authors.initials: JG
authors.lastname: Nutt
mesh_terms: D000978:Antiparkinson Agents / Q000009:adverse effects*; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology*; D020820:Dyskinesias / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D009068:Movement; D010300:Parkinson Disease / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology*
chemical_list: D000978:Antiparkinson Agents; D007980:Levodopa