PNA biosensors for nucleic acid detection.
Biosensor devices, based on the conversion of nucleic acid recognition reactions into useful electrical signals, offer considerable promise for DNA diagnostics. The unique hybridization properties of solution-phase PNA can be extrapolated onto transducer surfaces in connection with the design of remarkably specific DNA biosensors. This article reviews the development of PNA biosensors, and discusses common PNA-biosensing protocols along with their prospects in DNA biosensor technology.
Wang
J
J
Department of Chemistry and Biochemistry, New Mexico State University, Las Cruces, NM 88003, USA.
D015374:Biosensing Techniques; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D009693:Nucleic Acid Hybridization / Q000379:methods*; D020135:Peptide Nucleic Acids / Q000235:genetics / Q000378:metabolism*; D014159:Transducers
D020135:Peptide Nucleic Acids; D004247:DNA