[Molecular science of the living organism: the case of G-proteins].
The concept of Molecular Science of the Living Organism was described, where the living state is explained as the purposive flows of the quantum mechanically controlled chemical reaction systems which support the homeostasis of the living organism. In the 21st century, the post genomic sequence era, the concept may be a self-evident truth. Molecular Science of the Living Organism was presented in the case of G-proteins: i.e., the atomically controlled mechanism of 1. the carcinogenesis which originates from the point mutation of ras p21, 2. the activation of a receptor protein at the cell membrane, especially in the case of bacteriorhodopsin, 3. the activation of an inactive G-protein by the activated receptor protein.
Tsuda
M
M
Laboratory of Physical Chemistry, Faculty of Pharmaceutical Sciences, Chiba University, Yayoi-cho, Inage-ku, Chiba 263-8522, Japan.
D019883:Alkyl and Aryl Transferases / Q000235:genetics / Q000502:physiology; D001436:Bacteriorhodopsins / Q000737:chemistry / Q000502:physiology; D019295:Computational Biology; D019204:GTP-Binding Proteins / Q000378:metabolism / Q000502:physiology; D020690:GTPase-Activating Proteins / Q000502:physiology; D011905:Genes, ras / Q000235:genetics; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000235:genetics; D017354:Point Mutation; D011487:Protein Conformation; D011522:Protons
D020690:GTPase-Activating Proteins; D011522:Protons; D006153:Guanosine Diphosphate; D001436:Bacteriorhodopsins; D006160:Guanosine Triphosphate; D019883:Alkyl and Aryl Transferases; C064911:p21(ras) farnesyl-protein transferase; D019204:GTP-Binding Proteins