Effect of Aegle marmelos and Hibiscus rosa sinensis leaf extract on glucose tolerance in glucose induced hyperglycemic rats (Charles foster).
In an effort to test the hypoglycemic activity of Aegle marmelos and Hibiscus rosa sinensis in glucose induced hyperglycemic rats, their alcoholic leaf extracts were studied. Both the groups of animals receiving either. A. marmelos or H. rosa sinensis leaf extract for seven consecutive days, at an oral dose equivalent to 250 mg kg-1 showed significant improvements in their ability to utilize the external glucose load. Average blood glucose lowering caused by A. marmelos and H. rosa sinensis was 67% and 39% respectively, which shows that former significantly (p < 0.001) improves the glucose tolerance curve. The magnitude of this effect showed time related variation with both the plants. Efficacy of A. marmelos and H. rosa sinensis was 71% and 41% of glybenclamide, respectively. These data throw some light on the possible mechanism of hypoglycemic activity of both the plants. The mechanism of action could be speculated partly to increased utilization of glucose, either by direct stimulation of glucose uptake or via the mediation of enhanced insulin secretion.
Sachdewa
A
A
Department of Chemistry, Faculty of Science, Dayalbagh Educational Institute, Dayalbagh, Agra-282 005, India.
Raina
D
D
Srivastava
A K
AK
Khemani
L D
LD
D000818:Animals; D001786:Blood Glucose / Q000187:drug effects*; D004195:Disease Models, Animal; D005947:Glucose; D005951:Glucose Tolerance Test; D006943:Hyperglycemia / Q000139:chemically induced / Q000517:prevention & control*; D007004:Hypoglycemic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D019660:Malvaceae; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use; D018515:Plant Leaves; D010946:Plants, Medicinal; D051381:Rats; D019685:Rosales
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D010936:Plant Extracts; D005947:Glucose