Efficient proline-catalyzed Michael additions of unmodified ketones to nitro olefins.
[reaction: see text] Here we describe the proline-catalyzed Michael addition of unmodified ketones to nitro olefins. This novel reaction provides gamma-nitro ketones in modest enantioselectivity yet excellent yields.
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Departments of Chemistry and Molecular Biology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. blist@scripps.edu
Pojarliev
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Martin
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