[Effect of electroacupuncture on succinate dehydrogenase of gentamycin induced ototoxic cochlear hair cells in guinea pigs].
OBJECTIVE
To observe the effect of electroacupuncture (EA) on succinate dehydrogenase (SDH) of gentamycin (GE) induced ototoxic cochlear hair cells.


METHODS
Preyer's reflex normal guinea pigs were selected and divided randomly into three groups: GE group, EA group, control group. Brainstem auditory evoked potential (BAEP) and SDH in the cochlear hair cells were taken as indexes. In the animals of GE group GE was alone injected intramuscularly 80 mg.kg-1.d-1 for 20 days, while in the animals of EA group GE and additional EA was applied once a day on Tinggong (SI19), Yifeng(SJ17) and Shenshu (UB23) points. EA lasted for 15 minutes.


RESULTS
In the GE group BAEP reaction threshold rose markedly, while that rose slightly in EA group. The difference was significant between two groups (P < 0.05). The change of SDH within cochlear hair cells and degree of hair cells injury in the EA group were lower than those in GE group.


CONCLUSIONS
EA therapy could relieve GE ototoxicity, protect SDH in cochlear hair cells and might be a possible mechanism of action of EA.
Kang
S
S
Department of Physiology, Taishan Medical College, Shandong 271000.
Zeng
Z
Z
Shi
X
X
D000818:Animals; D003051:Cochlea / Q000201:enzymology*; D015834:Cochlear Diseases / Q000139:chemically induced / Q000201:enzymology; D015671:Electroacupuncture; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000201:enzymology; D008297:Male; D011897:Random Allocation; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D005839:Gentamicins; D013385:Succinate Dehydrogenase