title: Circuit and protocol for hypoxic hyperthermic isolated limb perfusion to treat malignant melanoma.
abstract: In the treatment of cancer, isolated limb perfusion (ILP) allows what would be a lethal systemic dose of cytotoxic drugs to be administered directly to a tumour site of an extremity. Unfortunately, ILP is a complex, expensive, time-consuming treatment that requires general anaesthesia, vascular surgery and expertise with extracorporeal circuits that may not be available outside a cardiac centre. By streamlining the traditional ILP protocols and eliminating the oxygenator from the circuit, an equally safe and effective technique of hypoxic hyperthermic isolated limb perfusion has been developed.
authors.affiliation: Department of Cardiothoracic Surgery-Perfusion, Waikato Hospital, Hamilton, New Zealand. innetl@hwl.co.nz
authors.forename: L M
authors.initials: LM
authors.lastname: Innet
authors.forename: V
authors.initials: V
authors.lastname: Haripershad
authors.forename: J
authors.initials: J
authors.lastname: Van Den Berg
authors.forename: L
authors.initials: L
authors.lastname: Cooper
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation / Q000379:methods*; D002985:Clinical Protocols; D005112:Extracorporeal Circulation / Q000295:instrumentation / Q000379:methods; D005121:Extremities / Q000098:blood supply; D006801:Humans; D006979:Hyperthermia, Induced; D000860:Hypoxia; D008545:Melanoma / Q000628:therapy*; D008558:Melphalan / Q000008:administration & dosage; D010107:Oxygenators, Membrane
chemical_list: D000970:Antineoplastic Agents; D008558:Melphalan