[Dendritic cells and interaction with other cell types. Immune tolerance].
T cell tolerance to self antigen is mainly established in the thymus were self-reactive T cells are deleted. Interdigitating dendritic cells and medulary epithelial cells are directly involved in the deletion process. Some self-reactive T cells escape, however this thymic censorship and enter the peripheral pool of naive T cells. Multiple mechanisms are also at play in the periphery to control this potentially armfull T cells, this include deletion and immune deviation.
Guerder
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Centre d'immunologie de Marseille Luminy, CNRS-INSERM, Université de la Méditerranée Parc scientifique de Luminy, case 906, 13288 Marseille, France.
D000818:Animals; D001324:Autoantigens / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D001324:Autoantigens