[Study on effect of Erigeron injection in prevention and treatment of cerebral ischemic injury].
OBJECTIVE
To study the effect of Erigeron injection (EI) on cerebral ischemic injury.


METHODS
Animal model of brain ischemic/reperfusion was established in male Wistar rats and the effect of EI on proteinkinase C (PKC) activity, intraneuronal free calcium and regional cortex blood flow (rCBF) were observed.


RESULTS
EI could prevent the activation of PKC, calcium overload and decrease of RCBF induced by cerebral ischemia/reperfusion.


CONCLUSIONS
EI could prevent neuronal ischemic injury by inhibiting activation of PKC.
Chen
K
K
Southwest Hospital, Third Military Medical College, Chongqing.
Dong
W
W
D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000378:metabolism*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000188:drug therapy / Q000517:prevention & control*
D004365:Drugs, Chinese Herbal; D011493:Protein Kinase C