title: Acute appendicitis in children: the importance of family history.
abstract: OBJECTIVE
  Acute appendicitis is common, frequently atypical, challenging, and still associated with significant morbidity. Despite major technologic advances, appendicitis remains a primarily clinical diagnosis. Therefore, no relevant anamnestic information should be overlooked. Surprisingly, the relationship between heredity and appendicitis is seldom considered. Because of the potential clinical importance of the family history, the authors addressed this question prospectively over a 52-month period in a practice that includes the majority of pediatric patients with appendicitis in the region.
  
  
  METHODS
  Family histories were obtained in a standardized manner, focusing on first-degree relatives. Children with incomplete family information were excluded. Patients (ages 2(1/2) to 19 years) were divided into 3 groups: group A, children who underwent an appendectomy (n = 166); group B (first control), children who presented with an acute abdomen and suspected appendicitis but did not undergo an appendectomy (n = 117); group C (second control), children who were seen in the practice for unrelated conditions (n = 141).
  
  
  RESULTS
  A positive parental history was obtained from 59 patients (36%) in group A, 24 patients (21%) in group B, and 20 patients (14%) in group C, and the odds ratios (ORs) were 2.0 (P =.035) and 2.9 (P <.001) for groups A versus B and A versus C, respectively. Of the 13 patients whose sibling had had acute appendicitis, 9 were in group A versus 2 each in groups B and C, and the OR for any family history (siblings, parents) in groups A versus B was 1.9 (P =.028) and for groups A versus C was 2.9 (P < 0.001). Appendicitis was histologically confirmed in 93% of children in group A.
  
  
  CONCLUSIONS
  Heredity is a significant factor in pediatric patients who have appendicitis. Children who have appendicitis are twice as likely to have a positive family history than are those with right lower quadrant pain (but no appendicitis) and almost 3 times as likely to have a positive family history than are surgical controls (without abdominal pain). Because of its potential value in changing the threshold for intervention, a careful family history should be obtained for every child in whom acute appendicitis is suspected.
authors.affiliation: Department of Pediatric Surgery, Children's Hospital, Greenville Hospital System, Greenville, SC, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Gauderer
authors.forename: M M
authors.initials: MM
authors.lastname: Crane
authors.forename: J A
authors.initials: JA
authors.lastname: Green
authors.forename: J M
authors.initials: JM
authors.lastname: DeCou
authors.forename: R S
authors.initials: RS
authors.lastname: Abrams
mesh_terms: D000006:Abdomen, Acute / Q000175:diagnosis / Q000628:therapy; D000208:Acute Disease; D017677:Age Distribution; D001062:Appendectomy; D001064:Appendicitis / Q000453:epidemiology* / Q000235:genetics* / Q000601:surgery; D016022:Case-Control Studies; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008487:Medical History Taking; D016017:Odds Ratio; D010375:Pedigree; D011336:Probability; D011446:Prospective Studies; D012016:Reference Values; D018570:Risk Assessment; D012307:Risk Factors; D017678:Sex Distribution; D018709:Statistics, Nonparametric