title: In search of truth: the role of systematic reviews and meta-analyses for assessing the effectiveness of rehabilitation with oral implants.
abstract: BACKGROUND
  It is difficult to determine the effectiveness or potential harm of dental therapies. Thus, any tools able to condense reliable scientific information would be of benefit.
  
  
  OBJECTIVE
  To discuss methods for the assessment of the scientific literature and, in particular, of systematic reviews for evaluating the effectiveness of oral implant rehabilitation procedures.
  
  
  METHODS
  Various study designs and methods to identify scientific evidence are described, discussed, and ranked. Issues on how to critically appraise randomized controlled clinical trials (RCTs) and systematic reviews are presented.
  
  
  RESULTS
  Properly conducted RCTs and structured critical systematic reviews are the gold standard of clinical research for assessing whether a therapeutic intervention is effective. In the field of oral implantology, there is an urgent need to implement more RCTs and to summarize their results in systematic reviews.
  
  
  CONCLUSIONS
  Searching of the truth requires training and critical skill. Dentists should be trained on how to integrate their clinical experience with evidence-based research and on how to discriminate between clinically useful scientific information and less useful research.
authors.affiliation: NIOM (Scandinavian Institute of Dental Materials) Haslum, Norway. marco.esposito@anatcell.gu.se
authors.forename: M
authors.initials: M
authors.lastname: Esposito
authors.forename: H V
authors.initials: HV
authors.lastname: Worthington
authors.forename: P
authors.initials: P
authors.lastname: Coulthard
mesh_terms: D000818:Animals; D018849:Controlled Clinical Trials as Topic; D016206:Databases, Bibliographic; D003657:Decision Making; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D018865:Dental Research / Q000379:methods*; D019317:Evidence-Based Medicine; D006801:Humans; D015201:Meta-Analysis as Topic; D012196:Review Literature as Topic; D016388:Tooth Loss / Q000534:rehabilitation
chemical_list: D015921:Dental Implants