[Clinical and experimental study on treatment of acute alcohol intoxication with xiangnaojing injection].
OBJECTIVE
To study the therapeutical mechanism of traditional Chinese medicine Xingnaojing injection (XNJI) for acute alcohol intoxication.


METHODS
XNJI was used in treating the experimental model rabbits (n = 26) and the patients (n = 8) admitted to the emergency department with acute alcoholism. Before and after the treatment, beta-EP, superoxide anion (free radicals) and SOD were measured.


RESULTS
XNJI could enhance the regaining consciousness of rabbits and patients, simultaneously reduce the concentration of beta-EP in plasma to the normal level (drunk rabbits 127.09 +/- 13.67 ng/L, normal rabbits 41.48 +/- 7.46 ng/L. P < 0.01, drunk patients 292.97 +/- 14.85 ng/L, normal people 221.60 +/- 15.95 ng/L, P < 0.01). The concentration change of superoxide anion (free radicals) in plasma of rabbits and patients was similar to beta-EP (drunk rabbits 313.39 +/- 15.64 u/L, normal rabbits 254.27 +/- 21.71 u/L, P < 0.01; drunk patients 278.47 +/- 11.48 u/L, normal people 159.92 +/- 11.51 u/L, P < 0.01), and SOD was inversely changed (drunk rabbits 53.57 +/- 6.48%, normal rabbits 77.18 +/- 7.89%, P < 0.01; drunk patients 43.76 +/- 7.84%, normal people 82.53 +/- 4.33%, P < 0.01).


CONCLUSIONS
XNJI is similar to Naloxone in pharmacologic action. And it is an effective antioxidant. It can be used for treating alcoholism.
Bai
J
J
Department of Emergency Medicine, China-Japan Friendship Hospital, Beijing 100029.
Zeng
Q
Q
Chai
Z
Z
D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood / Q000188:drug therapy*; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011817:Rabbits; D013482:Superoxide Dismutase / Q000097:blood; D001615:beta-Endorphin / Q000097:blood
D000975:Antioxidants; D004365:Drugs, Chinese Herbal; D001615:beta-Endorphin; D013482:Superoxide Dismutase