[The research on effect of four kinds of substitutive materials for the bone tissues on IGF-I mRNA expression level of osteoblast].
The authors studied the expression level of IGF-I mRNA of osteoblasts cultured from the rats' calvarias, affected by four kinds of substitutive materials for bone tissues, using the technique in situ hybridization. The result showed that the substitutive materials could affect the expression level of IGF-I mRNA of osteoblasts. The measurement of expression regulation may be a parameter for evaluation of biocompatibility of substitutive materials for bone tissues.
Ou
G
G
College of Stomatology, West China University of Medical Sciences, China.
Chen
Z
Z
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D018786:Bone Substitutes / Q000494:pharmacology*; D002478:Cells, Cultured; D003722:Dental Alloys / Q000494:pharmacology; D003776:Dental Porcelain / Q000494:pharmacology; D006882:Hydroxyapatites / Q000494:pharmacology; D017403:In Situ Hybridization; D007334:Insulin-Like Growth Factor I / Q000096:biosynthesis* / Q000235:genetics; D010006:Osteoblasts / Q000166:cytology / Q000378:metabolism*; D010294:Parietal Bone / Q000166:cytology*; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014025:Titanium / Q000494:pharmacology
D001672:Biocompatible Materials; D018786:Bone Substitutes; D003722:Dental Alloys; D006882:Hydroxyapatites; D012333:RNA, Messenger; D003776:Dental Porcelain; D007334:Insulin-Like Growth Factor I; D014025:Titanium