Virus subversion of immunity: a structural perspective.
Over the past year, we have witnessed the discovery of further virus immuno-evasins--proteins that alter the host immune response. Although many of these factors have been described over the past decade, the structural basis underlying their biology has lagged behind. Structural data have now been obtained for several such proteins. Major advances of the past year include the structures of a viral chemokine-binding protein, of an intact viral regulator of complement activation and of an immuno-evasin with its cellular target.
Gewurz
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Department of Pathology, Harvard Medical School, Building D2, Room 137, 200 Longwood Avenue, Boston, MA 02115, USA. Benjamin_gewurz@student.hms.harvard.edu
Gaudet
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Tortorella
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Wang
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Ploegh
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D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters / Q000037:antagonists & inhibitors; D000595:Amino Acid Sequence; D000818:Animals; D018925:Chemokines / Q000037:antagonists & inhibitors; D003167:Complement Activation; D016207:Cytokines / Q000737:chemistry / Q000276:immunology; D005802:Genes, MHC Class II; D015395:Histocompatibility Antigens Class I / Q000378:metabolism; D006801:Humans; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D014759:Viral Envelope Proteins / Q000235:genetics / Q000276:immunology; D014764:Viral Proteins / Q000737:chemistry / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology*; D014780:Viruses / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity
D000071181:ATP Binding Cassette Transporter, Subfamily B, Member 2; D018528:ATP-Binding Cassette Transporters; D018925:Chemokines; D016207:Cytokines; D015395:Histocompatibility Antigens Class I; C073119:TAP1 protein, human; C118670:US2 protein, Varicellovirus; D014759:Viral Envelope Proteins; D014764:Viral Proteins