title: Inverse T(2) contrast at 1.5 Tesla between gray matter and white matter in the occipital lobe of normal adult human brain.
abstract: T(2) of cortical gray matter is generally assumed to be longer than that of white matter. It is shown here that this is not the case in the occipital lobe, but that this effect is often obscured at lower resolution and concealed in standard T(2)-weighted images. Using a high-resolution (1 x 1.3 x 2 mm(3)) segmented EPI Carr-Purcell-Meiboom-Gill sequence, T(2) relaxation times of the brain were measured at 1.5 T for eight healthy adult volunteers. The average T(2) values of cortical gray and white matter were found to be 88 +/- 2 and 84 +/- 3 msec in the frontal lobe, 84 +/- 2 and 83 +/- 3 msec in the parietal lobe, and 79 +/- 1 and 87 +/- 3 msec in the occipital lobe, respectively. This unexpected occipital T(2) contrast between gray and white matter is attributed to regional differences in iron concentration.
authors.affiliation: Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205-2195, USA. jzhou@mri.jhu.edu
authors.forename: J
authors.initials: J
authors.lastname: Zhou
authors.forename: X
authors.initials: X
authors.lastname: Golay
authors.forename: P C
authors.initials: PC
authors.lastname: van Zijl
authors.forename: M J
authors.initials: MJ
authors.lastname: Silvennoinen
authors.forename: R
authors.initials: R
authors.lastname: Kauppinen
authors.forename: J
authors.initials: J
authors.lastname: Pekar
authors.forename: M
authors.initials: M
authors.lastname: Kraut
mesh_terms: D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods*; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism; D008297:Male; D009778:Occipital Lobe / Q000033:anatomy & histology* / Q000378:metabolism
chemical_list: D007501:Iron