Syntheses and effect of bombesin-fragment6-14 and its four analogues on food intake in rats.
A nonapeptide, H-Asn-Gln-Trp-Ala-Val-Gly-His-Leu-Met-NH2, corresponding to amino acids 6 to 14 of bombesin and its four analogues were synthesized by a solid-phase method and were tested for their comparative effect on reducing activity on food intake using male Wistar rats. The synthetic bombesin-fragment6-14 showed reducing effect on food intake using male Wistar rats. Of the synthetic analogues, [Phe(4F)13]bombesin-fragment6-14 exhibited the most potent effect. The reducing effect on food intake of [Sar11]bombesin-fragment6-14 was lower than that of our synthetic bombesin-fragment6-14, but the other two analogues, [betaAla11]bombesin-fragment6-14 and [1-Nal8]bombesin-fragment6-14 showed no reducing effect on food intake in rats.
Abiko
T
T
Research Laboratory, Global Shinwa Pharmaceutical Co., Ltd., Japan. lab@mx2.alpha-web.ne.jp
Kimura
Y
Y
D000818:Animals; D001839:Bombesin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D001839:Bombesin