Overexpression of Id-1 protein is a marker for unfavorable prognosis in early-stage cervical cancer.
Inhibitor of differentiation/DNA binding (Id) proteins are transcription factors, involved in cell cycle regulation and neoangiogenesis. Using immunohistochemistry, we investigated the prognostic influence of Id-1, Id-2, and Id-3 expression in 89 patients with cervical cancer stage pT(1b). In univariate and multivariate analysis, patients with strong or moderate expression of Id-1 had a significant shorter overall survival time (P = 0.0144, log-rank test) and disease-free survival time (P = 0.0107, log-rank test) compared with those with low or absent Id-1 expression. Id-1 expression is an independent prognostic marker in early-stage cervical cancer.
Schindl
M
M
Institute of Clinical Pathology, University of Vienna, Waeringer Guertel 18-20, A-1090 Vienna, Austria.
Oberhuber
G
G
Obermair
A
A
Schoppmann
S F
SF
Karner
B
B
Birner
P
P
D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000502:physiology; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000502:physiology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D051798:Inhibitor of Differentiation Protein 1; D051797:Inhibitor of Differentiation Protein 2; D051796:Inhibitor of Differentiation Proteins; D008833:Microcirculation; D015999:Multivariate Analysis; D009363:Neoplasm Proteins; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000378:metabolism; D011379:Prognosis; D012097:Repressor Proteins; D015996:Survival Rate; D014157:Transcription Factors / Q000096:biosynthesis* / Q000502:physiology; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; D004268:DNA-Binding Proteins; C497453:ID1 protein, human; C497450:ID2 protein, human; D051798:Inhibitor of Differentiation Protein 1; D051797:Inhibitor of Differentiation Protein 2; D051796:Inhibitor of Differentiation Proteins; D009363:Neoplasm Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; C075640:ID3 protein, human