title: Alcohol, aging, and cognitive performance in a cohort of Japanese Americans aged 65 and older: the Kame project.
abstract: OBJECTIVE
  To investigate the effects of light to moderate alcohol consumption on cognitive performance.
  
  
  METHODS
  A cross-sectional analysis including older Japanese Americans in King County, WA, enrolled in the Kame Project, a population-based study of cognition, dementia, and aging.
  
  
  METHODS
  1,836 cognitively intact participants aged 65 and older who participated in the baseline (1992-1994) examination.
  
  
  METHODS
  Cognitive performance was measured using the Cognitive Abilities Screening Instrument, reaction time (simple and choice), and a measure of vocabulary (North American Adult Reading Test).
  
  
  RESULTS
  Multivariate analyses were used to examine the relationship between cognitive performance and alcohol consumption at baseline with men and women together and then separately controlling for age, education, smoking, history of stroke, angina, hypertension, diabetes, and coronary heart disease. Findings showed lower cognitive test scores were observed for men who were either abstainers or in the heavy drinking group. For women, a linear relationship between alcohol consumption and cognitive performance was seen on two of the four measures of cognitive functioning. No significant difference in the association of drinking and cognitive function was identified within the different Japanese American subgroups.
  
  
  CONCLUSIONS
  RESULTS suggest a possible positive relationship between light to moderate drinking and cognitive performance in an aging Japanese American population. Additional long-term prospective and cross-cultural studies are needed to determine the generalizability of these findings to other aging cohorts.
authors.affiliation: Department of Psychosocial and Community Health University of Washington, Seattle 98195-7263, USA. gbond@u.washington.edu
authors.forename: G E
authors.initials: GE
authors.lastname: Bond
authors.forename: R
authors.initials: R
authors.lastname: Burr
authors.forename: S M
authors.initials: SM
authors.lastname: McCurry
authors.forename: A B
authors.initials: AB
authors.lastname: Graves
authors.forename: E B
authors.initials: EB
authors.lastname: Larson
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000523:psychology*; D000428:Alcohol Drinking / Q000523:psychology*; D001213:Asian / Q000523:psychology* / Q000706:statistics & numerical data; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D003071:Cognition / Q000187:drug effects*; D003430:Cross-Sectional Studies; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D011446:Prospective Studies; D012107:Research Design; D012737:Sex Factors; D013695:Temperance / Q000523:psychology
chemical_list: D002492:Central Nervous System Depressants; D000431:Ethanol