title: Spinal intramedullary metastases. Report of two cases and review of the literature.
abstract: Two cases of intramedullary metastasis were observed in our department within a short period of time that change the picture of uncommon locations of spinal metastases as described in literature. The patients presented primarily with rapidly progressing flaccid paraparesis of the lower extremities. Both additionally described diffusely located hypesthesia and pallhypesthesia of the limbs. One complained about sphincter disturbance. Both were treated by laminectomy and microsurgical extirpation of the tumor. In the first case reported here, an intramedullary metastasis of an epithelioid sarcoma in the conus medullaris region was ascertained which may be regarded as the first such reported case. In the second case report, histologic findings confirmed a thoracic intramedullary metastasis of a mastocarcinoma. At follow-up 6 and 8 months postoperatively, we observed full recovery of neurologic function in one patient and partial recovery in the other. Intramedullary metastases are extremely rare. Clinical presentation may show rapid onset and outcome is related to rapid resection and adjuvant therapy. In contrast to intracerebral metastases, this is a remarkable incidence of sarcomatous intramedullary metastatic disease.
authors.affiliation: Department of Neurosurgery, University of Essen Medical School, Germany. thomas.gasser@uni-essen.de
authors.forename: T G
authors.initials: TG
authors.lastname: Gasser
authors.forename: J
authors.initials: J
authors.lastname: Pospiech
authors.forename: D
authors.initials: D
authors.lastname: Stolke
authors.forename: K
authors.initials: K
authors.lastname: Schwechheimer
mesh_terms: D001943:Breast Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D005542:Forearm / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D012509:Sarcoma / Q000556:secondary* / Q000628:therapy*; D013120:Spinal Cord Neoplasms / Q000556:secondary* / Q000628:therapy*