[The effect of the molecular triggers of hemostatic activity on thrombosis in early stage of electrical injuries].
OBJECTIVE
To evaluate the mechanisms of thrombosis in the early stage of electrical injury.


METHODS
Endothelin-1(ET-1), prostacylin(PGI2), platelet alpha-granule membrane protein (Gmp-140), thromboxane (TXB2), and plasminogen(PLG-A) were measured in 26 patients with electrical injury.


RESULTS
It was found that GMP-140 and ET-1 increased significantly(P < 0.01), PLG-A showed a significant change 2 weeks after the injury, while there was an imbalance between TXB2 and PGI2.


CONCLUSIONS
It is believed that change in one or several mediators mentioned above may trigger thrombosis after electrical injury.
Chen
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G
Department of Burns and Plastic Surgery, Shanghai Power Hospital, Shanghai, 200050.
Xu
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X
Chen
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H
D000293:Adolescent; D000328:Adult; D002058:Burns, Electric / Q000150:complications* / Q000378:metabolism; D019332:Endothelin-1 / Q000097:blood*; D011464:Epoprostenol / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin / Q000097:blood*; D013927:Thrombosis / Q000209:etiology*; D013929:Thromboxane B2 / Q000097:blood
D019332:Endothelin-1; D019007:P-Selectin; D013929:Thromboxane B2; D011464:Epoprostenol