[Expression of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome].
OBJECTIVE
To study the expression and implication of apoptosis regulatory protein bcl-2 and bax in endometrium of polycystic ovary syndrome (PCOS).


METHODS
The apoptosis regulatory protein expression of bcl-2 and bax protein in endometrium were investigated by immunohistochemical method in 18 PCOS and 27 normal subjects proliferative phase 10 and secretory phase 17.


RESULTS
Bcl-2 expression was higher in PCOS than that both in control proliferative phase (P < 0.05) and secretory phase (P < 0.001). Bax expression was not significantly different between PCOS and controls (P > 0.05).


CONCLUSIONS
The higher bcl-2 protein expression inhibits the endometrium apoptosis and plays an important role in the abnormal proliferative changes of endometrium in PCOS.
Chen
Y
Y
Third Hospital of Beijing Medical University, Beijing 100083.
Wang
Y
Y
Li
M
M
D000328:Adult; D017209:Apoptosis / Q000187:drug effects; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D011085:Polycystic Ovary Syndrome / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics; D019253:Proto-Oncogene Proteins c-bcl-2 / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D051028:bcl-2-Associated X Protein
C494826:BAX protein, human; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D012333:RNA, Messenger; D051028:bcl-2-Associated X Protein