title: Serial computed tomography is rarely necessary in patients with acute pancreatitis: a prospective study in 102 patients.
abstract: BACKGROUND
  CT has proved to be helpful in patients with acute pancreatitis for differentiating between mild and severe forms. Followup of acute pancreatitis with CT has been advocated but rarely studied. The aim of this study was to determine if late CT performed at day 7 might be helpful in establishing the prognosis or the type of complications, and to select a subgroup of patients in whom CT could be beneficial.
  
  
  METHODS
  Contrast-enhanced CT was performed at the admission day and 7 days after admission in 102 patients admitted for acute pancreatitis. The extent of pancreatic inflammation was classified according to Balthazar grade, and intrapancreatic necrosis on these examinations was prospectively assessed and compared with clinical and biologic data and with patient outcomes.
  
  
  RESULTS
  Among 102 patients, complications developed in 24 (23%). Complications developed in only 8% of patients with Ranson score <2, making routine early CT unnecessary. For the patients with Ranson score <2 and Balthazar grades A and B at day 1 CT, late CT seemed to be useless. Complication was suspected by clinical and biologic tests before day 7 in 22 of 24 complicated patients (92%), suggesting that CT could be proposed only in cases of clinical or biologic deterioration. Late CT was correlated with a complicated course in patients with Balthazar grades D and E or intrapancreatic necrosis >50%. Late CT was predictive of complications in cases of intrapancreatic necrosis enlarging since the first examination.
  
  
  CONCLUSIONS
  Our study showed that in acute pancreatitis: 1) there is little justification for systematic early CT, especially in patients with Ranson score <2, and 2) late CT does not need to be performed routinely, but only in cases of clinical or biologic worsening.
authors.affiliation: Department of Digestive Surgery, Lariboisière Hospital, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Munoz-Bongrand
authors.forename: Y
authors.initials: Y
authors.lastname: Panis
authors.forename: P
authors.initials: P
authors.lastname: Soyer
authors.forename: F
authors.initials: F
authors.lastname: Riché
authors.forename: M J
authors.initials: MJ
authors.lastname: Laisné
authors.forename: M
authors.initials: M
authors.lastname: Boudiaf
authors.forename: P
authors.initials: P
authors.lastname: Valleur
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000150:complications / Q000000981:diagnostic imaging*; D018579:Patient Selection; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed