Venom as a source of useful biologically active molecules.
In the specialty area of venomology, emergency physicians traditionally have been most interested in the description of a variety of envenomation syndromes and, subsequent to this, the most appropriate investigative and therapeutic strategies to employ when envenomation is present. Taking an alternative viewpoint, in this paper we have reviewed a selection of interesting areas of biomedical research in which venom components are being investigated for their potential as novel therapeutic agents, pesticides and ion-channel probes. In addition, we describe the molecular imaging tools of X-ray crystallography and nuclear magnetic resonance spectroscopy, key techniques in the development of rationally designed therapeutic agents.
Bailey
P
P
Department of Biochemistry, University of Western Australia, Australia. pbailey@iinet.net.au
Wilce
J
J
D001180:Arthropod Venoms / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D001315:Australia; D015195:Drug Design; D006801:Humans; D015640:Ion Channel Gating / Q000187:drug effects; D008387:Marine Toxins / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D012910:Snake Venoms / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use; D013329:Structure-Activity Relationship; D014688:Venoms / Q000737:chemistry / Q000494:pharmacology / Q000627:therapeutic use*
D001180:Arthropod Venoms; D008387:Marine Toxins; D012910:Snake Venoms; D014688:Venoms