Cutaneous signet ring cell carcinoma: a report of a case and review of the literature.
Primary cutaneous signet-ring cell carcinoma (CSRCC) is a very unusual but distinctive clinicopathologic entity. It is defined as a diffuse malignant epithelial neoplasia localized in dermis and subcutis without epidermal involvement, showing variable amounts of signet ring cells, without evidence of a visceral adenocarcinoma. We report a case of CSRCC in a 70-year-old man along with its histologic and ultrastructural characteristics, and review of previous cases. We describe their main diagnostic features and discuss its wide differential diagnosis.
González-Lois
C
C
Department of Pathology, University Hospital 12 de Octubre, Madrid, Spain.
Rodríguez-Peralto
J L
JL
Serrano-Pardo
R
R
Martínez-González
M A
MA
López-Ríos
F
F
D000368:Aged; D018279:Carcinoma, Signet Ring Cell / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology*