title: Condyloma acuminatum in a cynomolgus monkey (Macaca fascicularis).
abstract: Condyloma acuminatum was found on the penile shaft and glans of a wild-caught cynomolgus monkey. The characteristic cauliflower-like, digitated lesions corresponded histopathologically with epidermal hyperplasia, hyperkeratosis, hypergranulosis, pallor of the mid-spinous zone, and crowding of keratinocytes. Electron microscopy revealed 10 intranuclear viral particles. In situ hybridization studies using human DNA probes (pan-Human Papillomavirus [HPV] 6/11, HPV 16/18, and HPV 31/33) all failed to hybridize. Polymerase chain reaction using papillomavirus probes MY09, MY11, GP5, and GP6 failed to amplify HPV DNA. We conclude that this lesion likely is a viral-induced condyloma but that the virus is not detectable by using presently available human or monkey papillomavirus probes.
authors.affiliation: The Division of Laboratory Animal Resources and Department of Dermatology, State University of New York at Stony Brook, Stony Brook, NY 11794-8611, USA.
authors.forename: H P
authors.initials: HP
authors.lastname: Gordon
authors.forename: D A
authors.initials: DA
authors.lastname: Reim
authors.forename: S A
authors.initials: SA
authors.lastname: McClain
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000648:ultrastructure / Q000821:virology; D003218:Condylomata Acuminata / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D004279:DNA, Viral / Q000032:analysis; D006801:Humans; D017403:In Situ Hybridization / Q000662:veterinary; D015603:Keratinocytes / Q000648:ultrastructure / Q000821:virology; D008252:Macaca fascicularis; D008297:Male; D008854:Microscopy, Electron / Q000662:veterinary; D008992:Monkey Diseases / Q000473:pathology* / Q000821:virology; D010409:Penile Diseases / Q000473:pathology / Q000662:veterinary* / Q000821:virology; D016133:Polymerase Chain Reaction / Q000662:veterinary; D014771:Virion / Q000648:ultrastructure
chemical_list: D004279:DNA, Viral