Factors that predict the presence of sentinel lymph node metastasis in patients with melanoma.
BACKGROUND
This analysis was performed to identify prognostic factors that are predictive of sentinel lymph node (SLN) metastasis in melanoma.


METHODS
Analysis was performed of a multi-institutional, prospective, randomized trial of SLN biopsy for melanoma. Eligibility criteria included age 18 to 70 years, Breslow thickness of 1.0 mm or more, and clinically negative regional lymph nodes. SLNs were evaluated by serial sectioning and immunohistochemistry for S100. Univariate chi-square and multivariate logistic regression analyses were performed to assess factors predictive of the presence of a positive SLN. Probability values of less than.05 were considered significant.


RESULTS
SLNs were identified in 99.7% of patients. A total of 1058 patients were evaluated; 961 patients had complete data and were included in the statistical analysis. SLNs were positive for tumor in 208 of 961 patients (22%). Breslow thickness, Clark level, ulceration, and patient age were factors that were found to be independently predictive of the presence of SLN metastasis.


CONCLUSIONS
Increasing Breslow thickness, Clark level of more than III, the presence of ulceration, and patient age of 60 years or less are the most important independent prognostic factors associated with the finding of positive SLN in patients with melanoma.
McMasters
K M
KM
Division of Surgical Oncology, Department of Surgery, James Graham Brown Cancer Center, University of Louisville, KY 40202, USA.
Wong
S L
SL
Edwards
M J
MJ
Ross
M I
MI
Chao
C
C
Noyes
R D
RD
Viar
V
V
Cerrito
P B
PB
Reintgen
D S
DS
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis / Q000473:pathology*; D008297:Male; D008545:Melanoma / Q000453:epidemiology / Q000473:pathology*; D008875:Middle Aged; D015999:Multivariate Analysis; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012307:Risk Factors; D021701:Sentinel Lymph Node Biopsy; D012878:Skin Neoplasms / Q000453:epidemiology / Q000556:secondary*