title: [Comparison between copper needle insertion and stainless steel needle insertion into rabbit ear central veins].
abstract: OBJECTIVE
  The clinical application of copper needle insertion has been proceeded satisfactorily for peripheral vascular disorders. This work was to study the mechanism of the copper needle insertion on a pathological basis.
  
  
  METHODS
  Sixty rabbits were used in the experiments. The copper needle or the stainless steel needle was inserted into the ear central vein of the animal. Then the specimens of the central vein including its surrounding tissue were taken for light and electron microscopic examinations.
  
  
  RESULTS
  At 7 days after copper needle insertion, acute inflammation reaction of the venous wall and vascular thrombosis were revealed in the specimens. At 14 days, giant cells granuloma and destruction of the venous wall were seen. After 28 days to 2 months, granuloma and the residual destroyed venous wall were gradually absorbed and fibrosis resulted. The vascular inflammation and thrombosis caused by stainless steel needle insertion was slight and slow.
  
  
  CONCLUSIONS
  Copper needle treatment for vascular disorders is superior to the stainless steel needle.
authors.affiliation: Luhua Hospital, Tengzhou, Shandong 277527.
authors.forename: K
authors.initials: K
authors.lastname: Zhang
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: B
authors.initials: B
authors.lastname: Zi
mesh_terms: D000818:Animals; D003300:Copper; D004431:Ear, External / Q000098:blood supply*; D006391:Hemangioma / Q000628:therapy; D007249:Inflammation / Q000209:etiology; D009339:Needles; D011817:Rabbits; D011897:Random Allocation; D013193:Stainless Steel; D014680:Veins / Q000473:pathology; D020246:Venous Thrombosis / Q000209:etiology*
chemical_list: D013193:Stainless Steel; D003300:Copper