[Preliminary observation of immunotherapy on asthmatic guinea pig].
OBJECTIVE
To observe the effect of the anti-IL-5 monoclonal antibody(McAb) on eosinophils of the guinea pigs with asthma.


METHODS
Sensitized guinea pigs by OVA were divided into two groups randomly, which were treated with the McAb and normal saline (NS), respectively. Difference of peripheral blood eosinophil count (PBEC) among basal pre-treatment and post-treatment, and the difference of bronchoalveolar lavage fluid eosinophil count (BALFEC) between two groups above were compared.


RESULTS
The PBEC after treatment with the McAb [(1.63 +/- 0.26) x 10(9)/L] was lower than that before treatment [(1.76 +/- 0.27) x 10(9)/L] (P < 0.05) and the BALFEC of treatment group with the McAb was lower than that with NS [(0.41 +/- 0.06) x 10(9)/L vs. (0.46 +/- 0.07) x 10(9)/L] (P < 0.05).


CONCLUSIONS
The anti-IL-5 McAb has the ability to reduce the PBEC and the BALFEC.
Shi
J
J
Respiratory Department, Xijing Hospital, Xi'an, 710032.
Sun
B
B
Zhan
X
X
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D001249:Asthma / Q000139:chemically induced / Q000628:therapy*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D004804:Eosinophils / Q000166:cytology*; D006168:Guinea Pigs; D007167:Immunotherapy; D015848:Interleukin-5 / Q000276:immunology*; D007958:Leukocyte Count; D010047:Ovalbumin; D011897:Random Allocation
D000911:Antibodies, Monoclonal; D015848:Interleukin-5; D010047:Ovalbumin