Optimizing drug development: strategies to assess drug metabolism/transporter interaction potential-toward a consensus.
Tucker
G T
GT
Molecular Pharmacology and Pharmacogenetics, Division of Clinical Sciences, University of Sheffield, The Royal Hallamshire Hospital, UK.
Houston
J B
JB
Huang
S M
SM
D000818:Animals; D001692:Biological Transport; D001711:Biotransformation; D003580:Cytochromes / Q000037:antagonists & inhibitors; D015195:Drug Design; D004347:Drug Interactions; D004335:Drug and Narcotic Control; D004789:Enzyme Activation; D020536:Enzyme Activators; D004790:Enzyme Induction; D004791:Enzyme Inhibitors; D006801:Humans; D008657:Metabolic Clearance Rate; D010599:Pharmacokinetics
D003580:Cytochromes; D020536:Enzyme Activators; D004791:Enzyme Inhibitors