Effects of MCI-154, a calcium sensitizer, on cardiac function in endotoxemic rabbits.
OBJECTIVE
To observe the effects of MCI-154, a calcium sensitizer, on cardiac function after endotoxic shock.


METHODS
The rabbits were intravenously injected with MCI-154 0.1 mg.kg-1 at 10 h after the administration of endotoxin 1.0 mg.kg-1, followed by a continuous infusion of normal saline (NS) 50 mL.kg-1 + MCI-154 0.1 mg.kg-1. During this process, the parameters of cardiac function were measured.


RESULTS
Ten hours after the endotoxin injection, heart rate (HR) increased noticeably while the mean arterial blood pressure (MAP), left ventricular systolic pressure (LVSP), isovolumetric pressure (IP), myocardial contractility (MC), and the area of p-dp/dtmax vector loop (Lo) were all markedly decreased. Treatment with NS 50 mL.kg-1 alone had slight effects on these parameters. LVSP, IP, MC, and Lo were all markedly increased while HR did not obviously change and left ventricular end-diastolic pressure (LVEDP) was reduced markedly following MCI-154 administration in endotoxic shock rabbits. The parameters of MC were improved nearly to the same values as in sham shock group and were markedly higher than in NS treated group.


CONCLUSIONS
MCI-154 exerts remarkable therapeutic effects on cardiac dysfunction after endotoxic shock.
Mei
J M
JM
Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China.
Hu
D Y
DY
Chen
H S
HS
Liu
L M
LM
Xiao
N
N
Chen
H H
HH
Lu
R Q
RQ
D000818:Animals; D002118:Calcium / Q000502:physiology; D002316:Cardiotonic Agents / Q000494:pharmacology*; D004731:Endotoxins; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D011724:Pyridazines / Q000494:pharmacology*; D011817:Rabbits; D011897:Random Allocation; D012772:Shock, Septic / Q000139:chemically induced / Q000503:physiopathology*; D016277:Ventricular Function, Left / Q000187:drug effects*
D002316:Cardiotonic Agents; D004731:Endotoxins; D011724:Pyridazines; C052228:MCI 154; D002118:Calcium