Immunotactoid glomerulopathy with massive bone marrow deposits in a patient with IgM kappa monoclonal gammopathy and hypocomplementemia.
A case of immunotactoid glomerulopathy with an amyloid-like material in the glomeruli and bone marrow is described. Clinically the patient was diagnosed as having severe nephrotic syndrome, hypocomplementemia, and IgM kappa monoclonal gammopathy. Immunotactoid glomerulopathy is an unusual cause of glomerulonephritis, characterized by Congo red-negative, amyloid-like deposits in the glomeruli. This unusual case presentation shows that immunotactoid glomerulopathy may be a manifestation of systemic disease. This patient also presented with hypocomplementemia, an extremely rare associated finding that has been reported previously in only four cases of immunotactoid glomerulopathy.
Da'as
N
N
Internal Medicine Section, and Nephrology Unit, Bikur Cholim Hospital, Jerusalem, Israel. daasn@surfree.net.il
Kleinman
Y
Y
Polliack
A
A
Amir
G
G
Ne'eman
Z
Z
Kopolovic
J
J
Bits
H
H
Darmon
D
D
D000368:Aged; D000682:Amyloid / Q000032:analysis*; D001706:Biopsy; D001853:Bone Marrow / Q000648:ultrastructure*; D004487:Edema / Q000209:etiology; D004727:Endothelium / Q000648:ultrastructure; D015432:Glomerulonephritis, Membranoproliferative / Q000175:diagnosis* / Q000276:immunology; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D007678:Kidney Glomerulus / Q000473:pathology*; D008297:Male; D008870:Microtubules / Q000648:ultrastructure; D008998:Monoclonal Gammopathy of Undetermined Significance / Q000276:immunology / Q000473:pathology*; D009404:Nephrotic Syndrome / Q000150:complications*
D000682:Amyloid; D007075:Immunoglobulin M; D007136:Immunoglobulins