title: Biotransformation of selamectin with Streptomyces lydicus SX-1298 using a novel static agar fermentation system with Reemay mesh.
abstract: A novel approach to biotransformation is described using a solid medium matrix and Reemay mesh that gives efficient biotransformation of compounds with minimal matrices in the ensuing gum solids. Using this approach with a newly isolated biotransforming organism, Streptomyces lydicus SX1298, a series of hydroxylations and an O-demethylation is described for selamectin the first endectocide for cats and dogs.
authors.affiliation: Veterinary Medicine Discovery, Pfizer Global Research and Development, Sandwich, Kent, UK. mike_pacey@sandwich.pfizer.com
authors.forename: M S
authors.initials: MS
authors.lastname: Pacey
authors.forename: M M
authors.initials: MM
authors.lastname: Barnes
authors.forename: R A
authors.initials: RA
authors.lastname: Monday
authors.forename: M
authors.initials: M
authors.lastname: Ritzau
authors.forename: E M
authors.initials: EM
authors.lastname: Wellington
mesh_terms: D000977:Antiparasitic Agents / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D001711:Biotransformation; D002853:Chromatography, Liquid; D005285:Fermentation; D007559:Ivermectin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism / Q000493:pharmacokinetics*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000977:Antiparasitic Agents; D007559:Ivermectin; C414354:selamectin