title: Measurement of plasma brain natriuretic peptide level as a guide for cardiac overload.
abstract: OBJECTIVE
  We examined whether measurement of the plasma BNP concentrations might be useful for the early diagnosis of the existence and severity of disease in patients with heart disease in daily clinical practice.
  
  
  RESULTS
  The plasma BNP and ANP concentrations in 415 patients with heart disease and hypertension and 65 control subjects were measured. Patients with heart disease had higher plasma BNP and ANP concentrations than did those with hypertension or control subjects. Among the etiology of cardiac diseases, specifically dilated cardiomyopathy and hypertrophic cardiomyopathy, was associated with the highest plasma BNP concentrations, whereas dilated cardiomyopathy was associated with the highest plasma ANP concentrations. Plasma BNP concentrations showed an increase as the severity of the heart disease, as graded according to the NYHA classification of cardiac function, increased. In both patients with heart disease and hypertension, the plasma BNP values were higher in those who had abnormalities in their echocardiogram and electrocardiogram as compared to those without any abnormalities. The plasma BNP levels also showed a significant correlation with left ventricular wall thickness and left ventricular mass. On the other hand, the plasma ANP levels showed significant correlations with left ventricular dimension. Receiver operative characteristic analysis revealed that plasma BNP levels showed substantially high sensitivity and specificity to detect the existence of heart diseases.
  
  
  CONCLUSIONS
  Measurements of the plasma BNP concentrations is useful to detect the existence of the diseases, and abnormalities of left ventricular function and hypertrophy in patients with heart disease in daily clinical practice.
authors.affiliation: Department of Cardiovascular Medicine, the University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan. hirata-2im@h.u-tokyo.ac.jp
authors.forename: Y
authors.initials: Y
authors.lastname: Hirata
authors.forename: A
authors.initials: A
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Aoyagi
authors.forename: K
authors.initials: K
authors.lastname: Yamaoki
authors.forename: I
authors.initials: I
authors.lastname: Komuro
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Ashida
authors.forename: T
authors.initials: T
authors.lastname: Sugiyama
authors.forename: Y
authors.initials: Y
authors.lastname: Hada
authors.forename: I
authors.initials: I
authors.lastname: Kuwajima
authors.forename: M
authors.initials: M
authors.lastname: Nishinaga
authors.forename: H
authors.initials: H
authors.lastname: Akioka
authors.forename: O
authors.initials: O
authors.lastname: Nakajima
authors.forename: R
authors.initials: R
authors.lastname: Nagai
authors.forename: Y
authors.initials: Y
authors.lastname: Yazaki
mesh_terms: D009320:Atrial Natriuretic Factor / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002311:Cardiomyopathy, Dilated / Q000097:blood / Q000175:diagnosis; D002312:Cardiomyopathy, Hypertrophic / Q000097:blood / Q000175:diagnosis; D006331:Heart Diseases / Q000097:blood* / Q000175:diagnosis*; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000175:diagnosis; D020097:Natriuretic Peptide, Brain / Q000097:blood*; D012372:ROC Curve; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D020097:Natriuretic Peptide, Brain; D009320:Atrial Natriuretic Factor