[Drug-induced fever caused by hydroxyurea. Apropos of 3 new cases].
Drug-induced fever is a frequent (3-5% of all adverse effects) but under recognized adverse effect of several drugs. Hydroxyurea, an antimetabolite cytostatic agent, has rarely been involved in the occurrence of fever. We report three additional cases of hydroxyurea-induced fever including one case with pulmonary involvement (acute alveolitis). In these cases, the role of hydroxyurea was strongly suggested by the delay to onset of symptoms (16-36 days), the disappearance of fever within a few hours after drug withdrawal, the recurrence of fever shortly after rechallenge in two patients, and the absence of any other obvious cause.
Gallant
C
C
Service de Pharmaco-Toxicovigilance et Centre Anti-Poisons, Hôpital Edouard-Herriot, Pavillon N, 69437 Lyon.
Vial
T
T
Allochon
Y
Y
Monier
J M
JM
Blanc
M
M
Evreux
J C
JC
D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D004791:Enzyme Inhibitors / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced; D012008:Recurrence; D013920:Thrombocythemia, Essential / Q000188:drug therapy
D000970:Antineoplastic Agents; D004791:Enzyme Inhibitors; D006918:Hydroxyurea