title: Neuropathic pain--from mice to men.
abstract: The past decade has seen great progress in understanding the syndrome of neuropathic pain, its causes and in finding new drugs that promise great benefit. For example, an early outcome of the research has been the observation that the new drugs do not blunt normal pain sensation--a pattern beginning to find explanation through the realisation that neural pain circuits rewire themselves, both anatomically and biochemically, after nerve injury. In this article, we discuss a case of a known diabetic patient with intractable pain and the course of management provided by the use of novel tools and devices coming to the fore in this rapidly expanding specialty.
authors.affiliation: Departments of Anaesthetics (in conjunction with the Parirenyatwa Pain Clinic), University of Zimbabwe.
authors.forename: H M
authors.initials: HM
authors.lastname: Chinyanga
authors.forename: K K
authors.initials: KK
authors.lastname: Kalangu
authors.forename: K
authors.initials: K
authors.lastname: Bhagat
mesh_terms: D000328:Adult; D003929:Diabetic Neuropathies / Q000150:complications*; D004599:Electric Stimulation Therapy / Q000295:instrumentation / Q000379:methods; D005260:Female; D006801:Humans; D009437:Neuralgia / Q000209:etiology* / Q000517:prevention & control*; D010147:Pain Measurement; D010148:Intractable Pain / Q000209:etiology* / Q000517:prevention & control*; D019736:Prostheses and Implants; D019051:Rhizotomy; D013126:Spinal Nerve Roots; D016896:Treatment Outcome