The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen.
The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.
Watson
S P
SP
Department of Pharmacology, University of Oxford, UK. steve.watson@pharm.ox.ac.uk
Asazuma
N
N
Atkinson
B
B
Berlanga
O
O
Best
D
D
Bobe
R
R
Jarvis
G
G
Marshall
S
S
Snell
D
D
Stafford
M
M
Tulasne
D
D
Wilde
J
J
Wonerow
P
P
Frampton
J
J
D020816:Amino Acid Motifs; D000818:Animals; D003094:Collagen / Q000494:pharmacology*; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects*; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D017434:Protein Structure, Tertiary; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction; D014443:Tyrosine
D010980:Platelet Membrane Glycoproteins; D011971:Receptors, Immunologic; C098341:platelet membrane glycoprotein VI; D014443:Tyrosine; D003094:Collagen