title: [Immune modulatory and therapeutic effect of lentinan on condyloma acuminatum].
abstract: OBJECTIVE
  To observe the immune modulatory and therapeutic effect of lentinan on condyloma acuminatum (CA).
  
  
  METHODS
  Thirty-six CA patients were randomly divided into two groups, 19 in the test group treated with lentinan plus CO2 laser irradiation and 17 in the control group treated with laser irradiation alone. Their T-lymphocyte subsets of peripheral blood and level of serum interleukin-2 (IL-2) and soluable interleukin-2 receptor (SIL-2R) were determined before and after treatment, and the recurrence rates of the two groups were compared.
  
  
  RESULTS
  After treatment, in the test group, the CD4/CD8 ratio, serum IL-2 raised and serum SIL-2R lowered significantly (P < 0.05, 0.05, 0.05 respectively) as compared with before treatment, while those parameters were not changed significantly in the control group. The recurrence rate of the test group was lower than that of the control group, P < 0.05.
  
  
  CONCLUSIONS
  Lentinan could modulate the cellular immunofunction of CA patients and reduce the recurrence rate of CA.
authors.affiliation: Department of Dermatology, First Affiliated Hospital of Henan Medical University, Zhengzhou 450052.
authors.forename: G
authors.initials: G
authors.lastname: Yin
authors.forename: J
authors.initials: J
authors.lastname: Yu
authors.forename: D
authors.initials: D
authors.lastname: Li
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D016516:CD4-CD8 Ratio; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000276:immunology* / Q000628:therapy; D005260:Female; D006801:Humans; D006896:Hydroxyethylrutoside; D007376:Interleukin-2 / Q000276:immunology*; D053685:Laser Therapy; D007912:Lentinan / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D055502:Secondary Prevention
chemical_list: D000276:Adjuvants, Immunologic; D006896:Hydroxyethylrutoside; D007376:Interleukin-2; D007912:Lentinan