title: [Studies on the mechanism of subcellular distribution of basic drugs based on their lipophilicity].
abstract: This paper described the studies on the mechanism of subcellular distribution of lipophilic weak bases. Although the tissue distribution of basic drugs appeared to decrease with time simply in parallel with their plasma concentration, their subcellular distribution in various tissues exhibited a variety of patterns. Basic drugs were distributed widely in various tissues, but were concentrated in lung granule fraction, where their accumulation was dependent on their lipophilicity and lysosomal uptake. As the plasma concentration of drugs decreased after maximum level, the contribution of lysosomes to their subcellular distribution increased. The uptake of the basic drugs into lysosomes depended both on their intralysosomal pH and on the drug lipophilicity. As the lipophilicity of the basic drugs increased, they accumulated more than the values predicted from the pH-partition theory and raised the intralysosomal pH more potently, probably owing to their binding with lysosomal membranes with or without additional intralysosomal aggregation. These phenomena should be considered as a basis of drug interaction in clinical treatments.
authors.affiliation: Department of Hospital Pharmacy, School of Medicine, Kanazawa University, Kanazawa 920-8641, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Ishizaki
authors.forename: K
authors.initials: K
authors.lastname: Yokogawa
authors.forename: S
authors.initials: S
authors.lastname: Ohkuma
authors.forename: F
authors.initials: F
authors.lastname: Ichimura
authors.forename: K
authors.initials: K
authors.lastname: Miyamoto
mesh_terms: D000818:Animals; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008055:Lipids; D008247:Lysosomes / Q000378:metabolism; D010599:Pharmacokinetics; D012995:Solubility; D013347:Subcellular Fractions / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D008055:Lipids