title: The multiple faces of Behçet's disease and its aetiological factors.
abstract: Behçet's disease (BD) is a chronic, inflammatory multisystemic condition of unknown aetiology. It is clinically characterized by recurrent orogenital ulcerations and skin eruptions; ocular manifestations; arthritis; vasculitis and in some cases neurological and large vessel involvement. Aetiology has not been defined, but genetic, environmental, viral, bacterial and immunological factors have been proposed as causative agents. Treatment includes colchicine, thalidomide, steroids and immunosuppressive agents and it is based on the severity of systemic manifestations, such as central nervous system involvement, arterial aneurysms and thrombosis of the major veins. Mortality is related to major system involvement. In this article the different clinical features, the multiple faces of BD and a list of currently suspected aetiological factors of the disease are discussed, and treatment modalities summarized.
authors.affiliation: Gazi University School Medicine, Department of Dermatology, Ankara, Turkey. monder@med.gazi.edu.tr
authors.forename: M
authors.initials: M
authors.lastname: Onder
authors.forename: M A
authors.initials: MA
authors.lastname: Gürer
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000890:Anti-Infective Agents / Q000008:administration & dosage; D001528:Behcet Syndrome / Q000175:diagnosis* / Q000188:drug therapy*; D002908:Chronic Disease; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D008297:Male; D011379:Prognosis; D012008:Recurrence; D018570:Risk Assessment; D012720:Severity of Illness Index
chemical_list: D000305:Adrenal Cortex Hormones; D000890:Anti-Infective Agents; D005343:Fibrinolytic Agents