Immunorestitution diseases in patients not infected with HIV.
The aim of this study was to assess the clinical spectrum of immunorestitution disease (IRD) in hospitalized patients over a 12-month period. In nine of 18 patients who presented with clinical deterioration during reduction or cessation of immunosuppressants (n = 6) or bone marrow engraftment (n = 3), IRD cases included the following infections: scabies infestation (n = 1); gastric strongyloidiasis (n = 1); hepatosplenic candidiasis (n = 1); methicillin-resistant Staphylococcus aureus abscess formation (n = 2); polyomavirus-related hemorrhagic cystitis (n = 3); and influenza A pneumonitis (n = 1). Immunopathological damage during withdrawal of immunosuppression is an incidental way to uncover an asymptomatic infectious disease. Serial monitoring of hematological and clinical profiles is essential in making a diagnosis of IRD.
Cheng
V C
VC
Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
Yuen
K Y
KY
Wong
S S
SS
Woo
P C
PC
Ho
P L
PL
Lee
R
R
Chan
R M
RM
D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D018655:Lymphocyte Count; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology; D011446:Prospective Studies
D007166:Immunosuppressive Agents