title: Sesquiterpene glucosides from anti-leukotriene B4 release fraction of Taraxacum officinale.
abstract: Chemical examination of the MeOH extract of the root of Taraxacum officinale, which exhibited inhibitory activity on the formation of leukotriene B4 from activated human neutrophils, has resulted in the isolation of 14-O-beta-D-glucosyl-11,13-dihydro-taraxinic acid (1) and 14-O-beta-D-glucosyl-taraxinic acid (2). The absolute stereostructure of 1 has been established by X-ray chrystallographic examination.
authors.affiliation: Niigata College of Pharmacy, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kashiwada
authors.forename: K
authors.initials: K
authors.lastname: Takanaka
authors.forename: H
authors.initials: H
authors.lastname: Tsukada
authors.forename: Y
authors.initials: Y
authors.lastname: Miwa
authors.forename: T
authors.initials: T
authors.lastname: Taga
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeshiro
mesh_terms: D019380:Anti-HIV Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D019659:Asteraceae / Q000737:chemistry*; D000001:Calcimycin / Q000494:pharmacology; D002478:Cells, Cultured / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D018360:Crystallography, X-Ray; D004305:Dose-Response Relationship, Drug; D005960:Glucosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects*; D006367:HeLa Cells; D006801:Humans; D007249:Inflammation / Q000209:etiology* / Q000503:physiopathology*; D007564:Japan; D007975:Leukotriene B4 / Q000037:antagonists & inhibitors / Q000502:physiology*; D008968:Molecular Conformation; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
chemical_list: C441308:14-O-glucosyl-11,13-dihydro-taraxinic acid; C441309:14-O-glucosyl-taraxinic acid; D019380:Anti-HIV Agents; D005960:Glucosides; D010936:Plant Extracts; D012717:Sesquiterpenes; D007975:Leukotriene B4; D000001:Calcimycin