title: Systemic inflammatory response syndrome in adult patients with nosocomial bloodstream infection due to Staphylococcus aureus.
abstract: To determine the impact of methicillin resistance on clinical course and outcome, we evaluated nosocomial bloodstream infections (BSIs) due to Staphylococcus aureus that were diagnosed in 82 adult patients at the Medical College of Virginia Hospitals from December 1995 through May 1997. Patients with BSI due to methicillin-resistant S. aureus were compared with patients with BSI due to methicillin-susceptible S. aureus; the groups did not differ with regard to inflammatory response or outcome. Mortality was predicted by systemic inflammatory response and Acute Physiology and Chronic Health Evaluation II score but did not correlate with bacterial resistance to methicillin.
authors.affiliation: Institute of Medical Microbiology, Immunology, and Hygiene, University of Cologne, Cologne, Germany. h.wisplinghoff@uni-koeln.de
authors.forename: H
authors.initials: H
authors.lastname: Wisplinghoff
authors.forename: H
authors.initials: H
authors.lastname: Seifert
authors.forename: M
authors.initials: M
authors.lastname: Coimbra
authors.forename: R P
authors.initials: RP
authors.lastname: Wenzel
authors.forename: M B
authors.initials: MB
authors.lastname: Edmond
mesh_terms: D018806:APACHE; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D015331:Cohort Studies; D003428:Cross Infection / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology* / Q000401:mortality; D005260:Female; D006801:Humans; D016015:Logistic Models; D008297:Male; D016106:Methicillin Resistance; D011237:Predictive Value of Tests; D013203:Staphylococcal Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology / Q000401:mortality; D013211:Staphylococcus aureus / Q000302:isolation & purification; D018746:Systemic Inflammatory Response Syndrome / Q000382:microbiology*
chemical_list: D000900:Anti-Bacterial Agents