title: Synthesis and antiproliferative activity of [2-(phthaloylamino)alkyl]triphenyl phosphonium derivatives against K562 cell line.
abstract: Given the reported cytotoxicity of phthaloylaminoethyltriphenylphosphonium bromide 2a in the P-388 cell line, we have developed new [2-(phthaloylamino)alkyl]phosphonium derivatives 2b-e and evaluated their cytotoxic activity. These compounds have been synthetized from N,N-phthaloylaminoalcohols and triphenylphosphonium hydrobromide via a one-pot reaction. 2a was found inactive in the K562 cell line, but 2c-e exhibited a cytotoxic activity with IC50 values about 1 microM.
authors.affiliation: Laboratoire de Chimie Thérapeutique, EA 635, Université Claude Bernard Lyon 1, Faculté de Pharmacie, 69008 Lyon, France.
authors.forename: F
authors.initials: F
authors.lastname: Ouenadio
authors.forename: N
authors.initials: N
authors.lastname: Walchshofer
authors.forename: C
authors.initials: C
authors.lastname: Trentesaux
authors.forename: R
authors.initials: R
authors.lastname: Barret
authors.forename: J
authors.initials: J
authors.lastname: Paris
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D006801:Humans; D020014:K562 Cells / Q000187:drug effects*; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000494:pharmacology*
chemical_list: D000970:Antineoplastic Agents; D009943:Organophosphorus Compounds