[Study on efficacy of Chinese Kidney-Tonifying Recipe in male rats with osteoporosis induced by dexamethasone and its mechanism].
OBJECTIVE
To study the efficacy of traditional Chinese Kidney-Tonifying Recipe (KTR) in male rats with osteoporosis induced by dexamethasone (DM) and its mechanism.


METHODS
Forty-six male Sprague-Dawley rats at 12 months of age were chosen: they were divided into four groups and KTR and DM were administered appropriately for 18 weeks. General bone mineral density, femur bending strength, serum-BGP, serum-PTH and serum-E2 were measured.


RESULTS
General bone mineral density, femur bending strength in KTR prevention group were significantly higher than those in DM group (P < 0.01) and the same with those in normal control group (P > 0.05). General bone mineral density, femur bending strength in KTR treatment group were higher than those in DM group (P < 0.05), and lower than those in normal control group. Compared with DM group, level of serum-T in KTR prevention group and KTR treatment group increased (P < 0.05) and level of serum-PTH in those two groups decreased (P < 0.05). But in comparison with DM group, level of serum-E2 and serum-BGP in the above-mentioned two groups was unchanged (P > 0.05).


CONCLUSIONS
The data indicated that traditional Chinese Kidney-Tonifying Recipe could prevent and treat osteoporosis in male rats induced by DM.
Shen
P
P
Institute of Traumatology and Orthopedics, Shanghai Academy of TCM, Shanghai 200032.
Chen
D
D
Zhang
G
G
D000818:Animals; D015519:Bone Density / Q000187:drug effects; D003907:Dexamethasone; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D010281:Parathyroid Hormone / Q000097:blood; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000097:blood*
D004365:Drugs, Chinese Herbal; D010281:Parathyroid Hormone; D013739:Testosterone; D003907:Dexamethasone