title: Lead compounds discovered from libraries.
abstract: Lead compounds with the potential to progress to viable drug candidates have been identified from libraries using several strategies. These include rapid screening of large diverse collections, thematic libraries, project-directed libraries, and three-dimensional molecular models of corporate databases. There have been numerous success stories, including the identification of several clinical candidates.
authors.affiliation: Procter & Gamble Pharmaceuticals, Health Care Research Center 45040-8006, Mason, OH, USA. golebiowskia@pg.com
authors.forename: A
authors.initials: A
authors.lastname: Golebiowski
authors.forename: S R
authors.initials: SR
authors.lastname: Klopfenstein
authors.forename: D E
authors.initials: DE
authors.lastname: Portlock
mesh_terms: D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D011506:Proteins / Q000737:chemistry
chemical_list: D011506:Proteins