[Neuroleptic malignant syndrome with rhabdomyolysis and muscle rupture].
We report a case of neuroleptic malignant syndrome (NMS) development after the ingestion of 960 mg of haloperidol in 18-year old male on the previous long-term neuroleptic treatment. Beside the severe rigidity and laboratory signs of rhabdomyolysis, firm swelling of gluteal and femoral areas, accompanied by pain and difficulty in the extension of the right leg, was noticed. The ultrasonography of the affected limb revealed partial rupture of quadriceps muscle. Since no signs of trauma or any other causes of muscle rupture were observed, we concluded that it developed due to the severe hypertonia and rhabdomyolysis in NMS. As there were no such cases previously reported, we wished to point out the possibility of muscle rupture development in NMS and propose the adequate diagnostic procedures and treatment.
Nikić
S
S
Jović-Stosić
J
J
Vucinić
S
S
Todorović
V
V
Babić
G
G
Srnić
D
D
Djordjević
D
D
Stojanović
V
V
Spasić
V
V
D000293:Adolescent; D014150:Antipsychotic Agents; D006220:Haloperidol / Q000506:poisoning*; D006801:Humans; D007866:Leg; D008297:Male; D018482:Muscle, Skeletal; D009135:Muscular Diseases / Q000139:chemically induced*; D009459:Neuroleptic Malignant Syndrome / Q000175:diagnosis / Q000209:etiology*; D012206:Rhabdomyolysis / Q000139:chemically induced*; D012422:Rupture, Spontaneous; D012559:Schizophrenia / Q000188:drug therapy
D014150:Antipsychotic Agents; D006220:Haloperidol