title: Sequential histological changes in Biomphalaria glabrata during the course of Schistosoma mansoni infection.
abstract: Biomphalaria glabrata, highly susceptible to Schistosoma mansoni, were seen to shed less and less cercariae along the time of infection. Histological examination kept a close correlation with this changing pattern of cercarial shedding, turning an initial picture of no-reaction (tolerance) gradually into one of hemocyte proliferation with formation of focal encapsulating lesions around disintegrating sporocysts and cercariae, a change that became disseminated toward the 142nd day post miracidial exposure. Findings were suggestive of a gradual installation of acquired immunity in snails infected with S. mansoni.
authors.affiliation: Laboratório de Patologia Experimental, Centro de Pesquisas Gonçalo Moniz-Fiocruz, 40295-001 Salvador, BA, Brasil.
authors.forename: Q T
authors.initials: QT
authors.lastname: Lemos
authors.forename: Z A
authors.initials: ZA
authors.lastname: Andrade
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000469:parasitology / Q000648:ultrastructure*; D004064:Digestive System / Q000469:parasitology / Q000473:pathology; D005088:Exocrine Glands / Q000469:parasitology / Q000473:pathology; D007668:Kidney / Q000469:parasitology / Q000473:pathology; D012550:Schistosoma mansoni / Q000302:isolation & purification; D012555:Schistosomiasis mansoni / Q000503:physiopathology*; D013997:Time Factors