title: Immunorestitution diseases in patients not infected with HIV.
abstract: The aim of this study was to assess the clinical spectrum of immunorestitution disease (IRD) in hospitalized patients over a 12-month period. In nine of 18 patients who presented with clinical deterioration during reduction or cessation of immunosuppressants (n = 6) or bone marrow engraftment (n = 3), IRD cases included the following infections: scabies infestation (n = 1); gastric strongyloidiasis (n = 1); hepatosplenic candidiasis (n = 1); methicillin-resistant Staphylococcus aureus abscess formation (n = 2); polyomavirus-related hemorrhagic cystitis (n = 3); and influenza A pneumonitis (n = 1). Immunopathological damage during withdrawal of immunosuppression is an incidental way to uncover an asymptomatic infectious disease. Serial monitoring of hematological and clinical profiles is essential in making a diagnosis of IRD.
authors.affiliation: Department of Microbiology, The University of Hong Kong, Queen Mary Hospital, Hong Kong.
authors.forename: V C
authors.initials: VC
authors.lastname: Cheng
authors.forename: K Y
authors.initials: KY
authors.lastname: Yuen
authors.forename: S S
authors.initials: SS
authors.lastname: Wong
authors.forename: P C
authors.initials: PC
authors.lastname: Woo
authors.forename: P L
authors.initials: PL
authors.lastname: Ho
authors.forename: R
authors.initials: R
authors.lastname: Lee
authors.forename: R M
authors.initials: RM
authors.lastname: Chan
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D018655:Lymphocyte Count; D008297:Male; D009894:Opportunistic Infections / Q000175:diagnosis / Q000276:immunology* / Q000382:microbiology; D011446:Prospective Studies
chemical_list: D007166:Immunosuppressive Agents