title: Angiocentric T-cell lymphoma of the pancreas presenting as late-onset diabetes mellitus with diabetic retinopathy.
abstract: Pancreatic lymphoma presenting with clinical diabetes mellitus (DM) is rare. We report angiocentric T-cell lymphoma of the pancreas in a 65-year-old Thai woman who presented with progressive deterioration of visual acuity of both eyes. She had diabetic retinopathy (DR) diagnosed only 20 months after the diagnosis of DM at the age of 63. She later developed erythematous rashes, fever, and deterioration of consciousness; she eventually died of shock. A skin biopsy and bone marrow examination revealed angiocentric T-cell lymphoma. At autopsy, the pancreas and both eyes were extensively infiltrated by lymphoma. Widespread involvement of nearly all organs but superficial lymphadenopathy was detected. In contrast to other typical cases of long-standing DM, only mild atherosclerosis was noted, and no DR was found. To the best of our knowledge, this is the first case of lymphoma involving the pancreas and both eyes producing clinical DM and DR.
authors.affiliation: Department of Pathology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.
authors.forename: S
authors.initials: S
authors.lastname: Sukpanichnant
authors.forename: T
authors.initials: T
authors.lastname: Sangruchi
authors.forename: P
authors.initials: P
authors.lastname: Prasopchoke
authors.forename: S
authors.initials: S
authors.lastname: Vatanavicharn
authors.forename: S
authors.initials: S
authors.lastname: Charoenratanakul
authors.forename: V
authors.initials: V
authors.lastname: Leenutaphong
authors.forename: K
authors.initials: K
authors.lastname: Kulthanan
authors.forename: W
authors.initials: W
authors.lastname: Cheunkongkaew
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis*; D003930:Diabetic Retinopathy / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D016399:Lymphoma, T-Cell / Q000737:chemistry / Q000175:diagnosis*; D010190:Pancreatic Neoplasms / Q000737:chemistry / Q000175:diagnosis*
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor