title: Methyl ethyl ketone peroxide ingestion: toxicity and outcome in a 6-year-old child.
abstract: A 6-year-old boy developed respiratory distress, metabolic acidosis, severe esophageal and gastric burns, and a coagulopathy after ingestion of an unknown volume of methyl ethyl ketone peroxide (MEKP) in dimethyl phthalate. He was discharged from the pediatric intensive care unit 19 days postingestion but subsequently developed a stricture of the gastroesophageal junction and complete fibrosis of the middle third of the stomach, necessitating gastric resection and reconstruction. He was discharged 93 days postingestion on a program of dilation for the residual esophageal stricture. MEKP acts by initiating lipid peroxidation via free radical production that results in cellular dysfunction and death. Acetylcysteine, a glutathione precursor and possible free radical scavenger, may be of use in severe MEKP poisoning. This case demonstrates the severe effects that some industrial chemicals can have both systemically and locally at the point of contact with the gastrointestinal tract, as well as the long-term management required to ensure good quality of life.
authors.affiliation: National Poisons Information Service, Medical Toxicology Unit, London SE14 5ER United Kingdom.
authors.forename: N
authors.initials: N
authors.lastname: Bates
authors.forename: C P
authors.initials: CP
authors.lastname: Driver
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
mesh_terms: D000061:Accidents, Home / Q000517:prevention & control; D002074:Butanones / Q000506:poisoning*; D002648:Child; D004940:Esophageal Stenosis / Q000139:chemically induced / Q000601:surgery; D004945:Esophagoscopy; D005355:Fibrosis / Q000139:chemically induced / Q000601:surgery; D006801:Humans; D008297:Male; D011041:Poisoning / Q000453:epidemiology / Q000209:etiology / Q000601:surgery; D013272:Stomach Diseases / Q000139:chemically induced / Q000601:surgery; D016896:Treatment Outcome
chemical_list: D002074:Butanones; C011007:methyl ethyl ketone peroxide