title: Neural cell adhesion molecule and neurothelin expression in human ameloblastoma.
abstract: OBJECTIVE
  The objective of the present study was to determine whether neural cell adhesion molecules (NCAM; CD56) and neurothelin (CD147) are expressed by adontogenic cells in the ameloblastoma.
  
  
  METHODS
  Frozen sections from ameloblastoma specimens (n = 7) were stained with monoclonal antibody-recognizing CD56 and CD147 molecules using indirect immunoperoxidase and indirect immunofluorescent techniques.
  
  
  RESULTS
  CD56 and CD147 molecules were strongly expressed by the peripheral columnar cells of the tumor nests. Neurothelin reactivity was also present in the stellate reticulum of the nests and in some stromal components.
  
  
  CONCLUSIONS
  The presence of these antigens in ameloblastoma supports the classic view about the neural crest origin of cells giving use to this tumor.
authors.affiliation: Received from the University of Hacettepe, Ankara, Turkey. nuer@hacettepe.edu.tr
authors.forename: N
authors.initials: N
authors.lastname: Er
authors.forename: A
authors.initials: A
authors.lastname: Dağdeviren
authors.forename: F
authors.initials: F
authors.lastname: Taşman
authors.forename: D
authors.initials: D
authors.lastname: Zeybek
mesh_terms: D000564:Ameloblastoma / Q000473:pathology*; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface / Q000032:analysis*; D030161:Avian Proteins; D051926:Basigin; D001798:Blood Proteins; D004396:Coloring Agents; D016650:Fluorescein-5-isothiocyanate; D019084:Fluorescent Antibody Technique, Indirect; D005456:Fluorescent Dyes; D006416:Hematoxylin; D006801:Humans; D007124:Immunoenzyme Techniques; D007573:Jaw Neoplasms / Q000473:pathology; D008562:Membrane Glycoproteins / Q000032:analysis*; D008856:Microscopy, Fluorescence; D019006:Neural Cell Adhesion Molecules / Q000032:analysis*; D009432:Neural Crest / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D030161:Avian Proteins; C497886:BSG protein, human; D001798:Blood Proteins; C102624:Bsg protein, Gallus gallus; C079432:Bsg protein, rat; D004396:Coloring Agents; D005456:Fluorescent Dyes; D008562:Membrane Glycoproteins; D019006:Neural Cell Adhesion Molecules; D051926:Basigin; D016650:Fluorescein-5-isothiocyanate; D006416:Hematoxylin