Signaling lymphocytic activation molecule is expressed on mature CD83+ dendritic cells and is up-regulated by IL-1 beta.
Signaling lymphocyte activation molecule (SLAM), a 70-kDa costimulatory molecule that mediates CD28-independent proliferation of T cells and IFN-gamma production, has been identified on human T cells, immature thymocytes, and a subset of B cells. We have found that SLAM is expressed on mature but not immature dendritic cells (DC). However, the SLAM-associated protein, is missing in DC. SLAM surface expression is strongly up-regulated by IL-1beta. Addition of IL-1beta to the DC maturation mixture also increases the stimulatory properties of DC. These findings provide a new marker for DC maturation and help to explain two areas of DC biology. First, SLAM is a receptor for the measles virus, previously shown to infect DC. Second, SLAM could possibly contribute to the enhanced immunostimulatory functions of DC that are observed following the addition of IL-1.
Kruse
M
M
Department of Dermatology and Institute for Clinical and Molecular Virology, University of Erlangen-Nürnberg, Erlangen, Germany.
Meinl
E
E
Henning
G
G
Kuhnt
C
C
Berchtold
S
S
Berger
T
T
Schuler
G
G
Steinkasserer
A
A
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D015703:Antigens, CD; D019013:CD40 Antigens / Q000276:immunology; D002454:Cell Differentiation / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology / Q000378:metabolism; D002478:Cells, Cultured; D003713:Dendritic Cells / Q000166:cytology / Q000276:immunology* / Q000378:metabolism*; D018984:Epitopes, T-Lymphocyte / Q000276:immunology; D006023:Glycoproteins / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D018799:Intercellular Adhesion Molecule-1 / Q000096:biosynthesis; D007375:Interleukin-1 / Q000494:pharmacology*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D010455:Peptides / Q000276:immunology; D020033:Protein Isoforms / Q000032:analysis / Q000235:genetics; D012333:RNA, Messenger / Q000032:analysis; D011956:Receptors, Cell Surface; D015398:Signal Transduction / Q000276:immunology*; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D015854:Up-Regulation / Q000276:immunology*; D000097802:CD83 Antigen
D000276:Adjuvants, Immunologic; D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D019013:CD40 Antigens; D018984:Epitopes, T-Lymphocyte; D006023:Glycoproteins; D007136:Immunoglobulins; D018799:Intercellular Adhesion Molecule-1; D007375:Interleukin-1; D008562:Membrane Glycoproteins; D010455:Peptides; D020033:Protein Isoforms; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D000071177:Signaling Lymphocytic Activation Molecule Family Member 1; D000097802:CD83 Antigen