title: Clinical and laboratory findings of cytomegalovirus infection in 115 hospitalized non-immunocompromised adults.
abstract: We report a retrospective study of 115 hospitalized non-immunocompromised adults with proved or presumed diagnosis of cytomegalovirus infection. Clinical symptoms were fever (95%), constitutive symptoms (80%), joint and muscle pain (41%), shivering (32%), abdominal pain (26%), non-productive cough (20%), cutaneous eruption (20%), and diarrhea (10%). Examination found hepatomegaly (25%), splenomegaly (23%), cutaneous rash (20%), adenopathy (19%), pharyngitis (9%), jaundice (3%) or signs of meningeal irritation (1%). Seventeen patients had a gastrointestinal form (hepatitis, jaundice, colitis, antral gastritis or cholecystitis), eight had a pattern of hemopathy, two interstitial pneumonitis, two pericarditis, two immune thrombocytopenic purpura, two a polymyalgia rheumatica-like pattern, one thrombotic thrombocytopenic purpura, one cutaneous vasculitis and one meningoencephalitis. Sixty-four percent of the patients had atypical lymphocytosis. Hepatocellular injury occurred in 90% of the patients. Nineteen of the patients had biological immune abnormalities. Cytomegalovirus infection should be mainly suspected in any patient with persistent fever, isolated or associated with signs of poor specificity, or in some patients with visceral manifestations of initially unknown origin.
authors.affiliation: Fédération de Médecine Interne, Maladies Infectieuses et Pathologies Tropicales, Hôpital Saint-André, 33075 Bordeaux Cedex. fabrice.bonnet@chu-bordeaux.fr
authors.forename: F
authors.initials: F
authors.lastname: Bonnet
authors.forename: D
authors.initials: D
authors.lastname: Neau
authors.forename: J F
authors.initials: JF
authors.lastname: Viallard
authors.forename: P
authors.initials: P
authors.lastname: Morlat
authors.forename: J M
authors.initials: JM
authors.lastname: Ragnaud
authors.forename: M
authors.initials: M
authors.lastname: Dupon
authors.forename: P
authors.initials: P
authors.lastname: Legendre
authors.forename: Y
authors.initials: Y
authors.lastname: Imbert
authors.forename: F
authors.initials: F
authors.lastname: Lifermann
authors.forename: M
authors.initials: M
authors.lastname: Le Bras
authors.forename: J
authors.initials: J
authors.lastname: Beylot
authors.forename: M
authors.initials: M
authors.lastname: Longy-Boursier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001772:Blood Cell Count; D003371:Cough / Q000821:virology; D003586:Cytomegalovirus Infections / Q000097:blood / Q000150:complications* / Q000175:diagnosis* / Q000276:immunology; D003967:Diarrhea / Q000821:virology; D005076:Exanthema / Q000821:virology; D005334:Fever / Q000821:virology; D005767:Gastrointestinal Diseases / Q000821:virology; D006529:Hepatomegaly / Q000821:virology; D006760:Hospitalization / Q000706:statistics & numerical data; D006801:Humans; D007121:Immunocompetence; D007565:Jaundice / Q000821:virology; D008206:Lymphatic Diseases / Q000821:virology; D008581:Meningitis / Q000821:virology; D008875:Middle Aged; D010146:Pain / Q000821:virology; D010493:Pericarditis / Q000821:virology; D010612:Pharyngitis / Q000821:virology; D012189:Retrospective Studies; D013163:Splenomegaly / Q000821:virology; D013921:Thrombocytopenia / Q000821:virology