Linear IgA dermatosis presenting with erythema annulare centrifugum lesions: report of three cases in adults.
Linear IgA dermatosis presented with erythema annulare centrifugum lesions in three elderly women. Search for underlying malignancy revealed low-grade B-cell lymphoma in one case. In addition to subepidermal blistering, histology showed a typical mixed infiltrate of granulocytes and eosinophils and, occasionally, papillar microabsesses in one case. In the two other subjects, characteristic subepidermal lining with granulocytes was observed. Immunofluorescence studies confirmed the diagnosis, while autoantibodies characteristic for dermatitis herpetiformis were absent. To our knowledge this is the second report of adult linear IgA dermatosis in association with erythema annulare centrifugum lesions. Our observations concord with several other reports of figurate erythema associated with autoimmune blistering disease and other immune disorders. Common antibody-related immunological mechanisms indicate that the two distinct clinical pictures are probably stages of the same pathogenic entity.
Dippel
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E
Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Germany.
Orfanos
C E
CE
Zouboulis
C
C
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle; D004892:Erythema Multiforme / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D011379:Prognosis; D012720:Severity of Illness Index; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology*
D000305:Adrenal Cortex Hormones; D007070:Immunoglobulin A