title: Opposite effects of calcium and magnesium on the central blood pressure regulation in the spontaneously hypertensive rats.
abstract: The effects of intracerebroventricular administration of calcium or magnesium on the blood pressure regulation in the brain were investigated. The systolic blood pressure in spontaneously hypertensive rats (male, 13-week-old) was decreased by calcium chloride (100 microg/rat) and increased by magnesium chloride (20, 100 or 500 microg/rat). The depressor response induced by calcium was inhibited by magnesium chloride in a dose-dependent manner. Combining these results with those previously reported, it is suggested that magnesium inhibits the ability of calcium to reduce blood pressure through calmodulin- and dopamine-dependent functions in the brain.
authors.affiliation: Institute of Medical Science, University of Tsukuba, Japan. dsutoo@md.tsukuba.ac.jp
authors.forename: D
authors.initials: D
authors.lastname: Sutoo
authors.forename: K
authors.initials: K
authors.lastname: Akiyama
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR
chemical_list: D008274:Magnesium; D002118:Calcium