Frequency of C3435T polymorphism of MDR1 gene in African people.
The variability of P-glycoprotein expression between individuals is linked to a C3435T polymorphism of the human MDR1 gene. Concentration of P-glycoprotein in intestinal epithelial cells and in a subset of lymphoid cells is substantially lower in people with the T/T genotype than those with the C/C genotype. We compared allele frequencies of the C3435T polymorphism in random samples of west African, African American, white, and Japanese people. We recorded a significantly higher frequency of the C/C genotype in West Africans and African Americans (142 of 172 [83%] and 25 of 41 [61%], respectively), than in white people (139 of 537 [26%]) (p<0.0001). These findings could affect use of drugs that are P-glycoprotein substrates (such as HIV-1 protease inhibitors and ciclosporin) in African populations.
Schaeffeler
E
E
Eichelbaum
M
M
Brinkmann
U
U
Penger
A
A
Asante-Poku
S
S
Zanger
U M
UM
Schwab
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000235:genetics*; D044466:Asian People; D044383:Black People; D005787:Gene Frequency; D019450:Genes, MDR / Q000235:genetics*; D005838:Genotype; D005869:Ghana; D006801:Humans; D011110:Polymorphism, Genetic; D011897:Random Allocation; D044465:White People; D001741:Black or African American
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1