title: Mercurochrome as an adjunct to local preoperative preparation in children undergoing hypospadias repair.
abstract: OBJECTIVE
  To determine whether the local application of mercurochrome over genital skin before surgery, in addition to soap/water scrubs, can help to decrease the incidence of infection patients undergoing hypospadias repair, and thereby the incidence of fistula formation.
  
  
  METHODS
  The study comprised 44 consecutive boys undergoing primary or repeat surgery for hypospadias between October 1999 and April 2000. They were arbitrarily divided into two groups; group 1 received a conventional local scrub with soap/water 48 h before surgery and group 2, a conventional local scrub with soap/water was followed by a local application of 2% mercurochrome for 48 h before surgery. Both groups were comparable in age, location of the meatus and stage of repair. All patients were exposed to similar conditions during and after surgery. Urine, skin and wound swabs taken before during and after surgery were assessed microbiologically, using standard precautions. The incidence of infection and complications was then compared.
  
  
  RESULTS
  Mercurochrome significantly decreased local infection, especially before surgery, but its effect in decreasing fistula formation, although appreciable, was not statistically significant.
  
  
  CONCLUSIONS
  The local application of mercurochrome after a soap/water scrub for at least 48 h before surgery is a simple, economic and effective means to decrease postoperative wound infection. Future studies are needed, keeping other determinants of fistula formation constant, to evaluate its role in decreasing fistula formation in patients undergoing hypospadias repair.
authors.affiliation: Department of Paediatric Surgery, Dr RML Hospital, All India Institute of Medical Sciences, Delhi, PIN 110017, India. drjohnsimmi@yahoo.com
authors.forename: S K
authors.initials: SK
authors.lastname: Ratan
authors.forename: A
authors.initials: A
authors.lastname: Sen
authors.forename: J
authors.initials: J
authors.lastname: Ratan
authors.forename: R M
authors.initials: RM
authors.lastname: Pandey
mesh_terms: D000287:Administration, Topical; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007021:Hypospadias / Q000601:surgery*; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008622:Merbromin / Q000008:administration & dosage*; D011300:Preoperative Care / Q000379:methods; D013530:Surgical Wound Infection / Q000517:prevention & control*; D014522:Urethral Diseases / Q000517:prevention & control; D014548:Urinary Fistula / Q000517:prevention & control
chemical_list: D000891:Anti-Infective Agents, Local; D008622:Merbromin