title: In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe.
abstract: This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity on lymph node T cells. Additionally, they were able to induce apoptosis and inflammation (frequently associated with high endothelial venule necrosis). The data presented here suggest that the Diocleinae lectins studied can stimulate in vivo T cell activation and apoptosis, as well as present important side effects.
authors.affiliation: Centro de Pesquisas Gonçalo Moniz-Fiocruz, 40295-001 Salvador, BA, Brasil.
authors.forename: T
authors.initials: T
authors.lastname: Barbosa
authors.forename: S
authors.initials: S
authors.lastname: Arruda
authors.forename: B
authors.initials: B
authors.lastname: Cavada
authors.forename: T B
authors.initials: TB
authors.lastname: Grangeiro
authors.forename: L A
authors.initials: LA
authors.lastname: de Freitas
authors.forename: M
authors.initials: M
authors.lastname: Barral-Netto
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002452:Cell Count; D004727:Endothelium / Q000098:blood supply; D007887:Fabaceae / Q000737:chemistry* / Q000235:genetics; D005260:Female; D007249:Inflammation / Q000139:chemically induced; D037102:Lectins / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis; D037121:Plant Lectins; D010946:Plants, Medicinal; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D014699:Venules / Q000473:pathology
chemical_list: D037102:Lectins; D037121:Plant Lectins; D015375:Receptors, Interleukin-2