title: The value of a single biopsy with 12 transperineal cores for detecting prostate cancer in patients with elevated prostate specific antigen.
abstract: OBJECTIVE
  Prostate cancer detection on standard sextant biopsy is considered inadequate. Various biopsy protocols have been introduced to improve cancer diagnosis. We report our experience with transperineal 12-core prostate biopsy.
  
  
  METHODS
  In a prospective study 650 patients underwent prostate specific antigen (PSA) measurement during a 15-month period, of whom 141 with PSA greater than 4 ng./ml. also underwent transperineal 12-core prostate biopsy using the fan technique. Median PSA was 8 ng./ml. (range 4.1 to 5,000).
  
  
  RESULTS
  Prostate cancer was detected in 72 of the 141 patients (51%), including 44 of the 97 (45%) with PSA between 4.1 and 10 ng./ml. This incidence is higher than previously reported in the literature using other biopsy techniques. Disease was low grade Gleason 2 to 4 in 4 cases (5%), intermediate grade Gleason 5 to 6 in 26 (35%) and high grade Gleason 7 to 10 in the remaining 42 (60%).
  
  
  CONCLUSIONS
  A high cancer detection rate is achieved by 12-core transperineal prostate biopsy. Most tumors represent clinically significant cancer. Further randomized trials are required to confirm these data.
authors.affiliation: Vincenzo Pansadoro Foundation and San Giovanni Hospital, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Emiliozzi
authors.forename: S
authors.initials: S
authors.lastname: Longhi
authors.forename: P
authors.initials: P
authors.lastname: Scarpone
authors.forename: A
authors.initials: A
authors.lastname: Pansadoro
authors.forename: F
authors.initials: F
authors.lastname: DePaula
authors.forename: V
authors.initials: V
authors.lastname: Pansadoro
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001707:Biopsy, Needle / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D008297:Male; D008875:Middle Aged; D010502:Perineum; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000473:pathology*
chemical_list: D017430:Prostate-Specific Antigen