title: Virus-associated hemophagocytic syndrome due to rubella virus and varicella-zoster virus dual infection in patient with adult idiopathic thrombocytopenic purpura.
abstract: A 26-year-old woman with idiopathic thrombocytopenic purpura (ITP) was admitted to our hospital because of fever and rash. Blood tests revealed thrombocytopenia, liver dysfunction, coagulopathy, and hyperferritinemia. Bone marrow examination revealed many atypical lymphocytes and some histiocytes with hemophagocytosis. On admission she was diagnosed with rubella virus-associated hemophagocytic syndrome (VHAS), but on laboratory examination, she was seropositive for varicella-zoster virus (VZV)-IgM as well as rubella virus-IgM. She was therefore diagnosed with dual infection by rubella virus and VZV. Her simultaneous rubella virus and VZV infection may have been related to the VAHS pathogenesis. She was treated with prednisolone and gamma globulin therapy and recovered completely.
authors.affiliation: Department of Clinical Hematology, Osaka City University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeoka
authors.forename: M
authors.initials: M
authors.lastname: Hino
authors.forename: N
authors.initials: N
authors.lastname: Oiso
authors.forename: S
authors.initials: S
authors.lastname: Nishi
authors.forename: K R
authors.initials: KR
authors.lastname: Koh
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: K
authors.initials: K
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Nakamae
authors.forename: Y
authors.initials: Y
authors.lastname: Aoyama
authors.forename: A
authors.initials: A
authors.lastname: Hirose
authors.forename: H
authors.initials: H
authors.lastname: Fujino
authors.forename: T
authors.initials: T
authors.lastname: Takubo
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: N
authors.initials: N
authors.lastname: Tatsumi
mesh_terms: D000328:Adult; D018572:Disease-Free Survival; D005260:Female; D006562:Herpes Zoster / Q000150:complications*; D015616:Histiocytosis, Non-Langerhans-Cell / Q000209:etiology / Q000473:pathology / Q000821:virology*; D006801:Humans; D007564:Japan; D011239:Prednisolone / Q000008:administration & dosage; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000150:complications* / Q000821:virology*; D012409:Rubella / Q000150:complications*; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D005719:gamma-Globulins; D011239:Prednisolone