title: Seroepidemiology and active surveillance of dengue fever/dengue haemorrhagic fever in Delhi.
abstract: The aims of the present study were to carry out surveillance for dengue virus infection in adults with short-duration fever, and serological study of dengue virus infection in persons without fever.  Patients were divided into two groups.  Group 1 included patients above 12 years of age with fever of  2-12 days duration without any apparent cause.  Of these, patients who presented with fever for 2-5 days were included for virus isolation (group 1a) while those who presented within 6-12 days of the onset of fever were included for the dengue-specific IgM serology (group 1b).  Group 2 included a sample of population belonging to all age groups but without pyrexia and blood was collected for  dengue-specific IgG serology.  Twenty-six patients were enrolled in group 1a over a period of 4 months (September to December, 1997).  Of these, DEN1 was isolated in 5 cases.  Group 1b included 182 patients, out of which 34 (18.68%) were positive for dengue-specific IgM antibodies.  Significantly, all the positive cases were detected during the months of September to November.  Retro-orbital pain was present in a significantly more number of  IgM-positive cases as compared to IgM-negative cases.  Group 2 included 125 cases without fever.  The overall positivity for dengue-specific IgG antibodies was 77.6%, with the highest positivity of 100% in the age group of 31-40 years.  It was concluded that dengue virus infection is endemic in  and around Delhi with peak incidence between September and Novemver.  The prevalent serotype during September and December 1997 was DEN1.  Since previous epidemic of DHF was due to DEN2 type, isolation of DEN1 serotype indicates changes of another epidemic of DHF due to DEN1 serotype.  The stresses the urgent need for  implementation of measures to control the transmission of dengue infection.
authors.affiliation: Department of Medicine, All India Institute of Medical Sciences, New Delhi-110 029.
authors.forename: M
authors.initials: M
authors.lastname: Kurukumbi
authors.forename: J P
authors.initials: JP
authors.lastname: Wali
authors.forename: S
authors.initials: S
authors.lastname: Broor
authors.forename: P
authors.initials: P
authors.lastname: Aggarwal
authors.forename: P
authors.initials: P
authors.lastname: Seth
authors.forename: R
authors.initials: R
authors.lastname: Handa
authors.forename: L
authors.initials: L
authors.lastname: Dhar
authors.forename: M
authors.initials: M
authors.lastname: Vajapayee
mesh_terms: D000328:Adult; D003715:Dengue / Q000453:epidemiology*; D003906:Developing Countries; D005260:Female; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D011159:Population Surveillance; D016036:Seroepidemiologic Studies; D019595:Severe Dengue / Q000453:epidemiology*; D014505:Urban Population / Q000706:statistics & numerical data*