[Comparison between the Eppendorf histograph and the Licox system for determination oxygen partial pressure in tumor tissue].
BACKGROUND
The oxygenation of a tumor is certainly one of the major facts influencing the response to treatment. pO2 measurement in tumor tissue can be done by using the Eppendorf-histograph. In recent years the Licox-system (GMS) was developed for oxygen tension measurement in tissues and fluids under clinical routine conditions and for research work. Aim of the present study was to assess the suitability of the Licox-system in drawing up histograms of pO2 values in tumor tissues.


METHODS
Histograms of the distribution of oxygen tension in twelve tumors were prepared with both measuring systems in parallel. Investigations were performed on rats with isotransplanted R1H rhabdomyosarcomas in continuous intravenous anesthesia with Fentanyl and Dormicum. Ventilation with a mixture of air and oxygen was applied through a tracheostoma. Arterial pressure and body temperature were analysed and balanced continuously.


RESULTS
No correspondence between data of both measuring methods could be found.


CONCLUSIONS
Because of constructional advantages the Eppendorf-histograph seems to be comparatively more suitable in drawing up histograms of oxygen tension tumor tissue.
Kehrl
W
W
Hals-Nasen-Ohrenklinik, Marienkrankenhaus Hamburg.
Sagowski
C
C
Wenzel
S
S
Metternich
F
F
Zywietz
F
F
D000818:Animals; D001785:Blood Gas Monitoring, Transcutaneous / Q000295:instrumentation*; D002138:Calibration; D015687:Cell Hypoxia / Q000502:physiology*; D004867:Equipment Design; D008410:Masticatory Muscles / Q000473:pathology; D008839:Microelectrodes; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D015203:Reproducibility of Results; D012208:Rhabdomyosarcoma / Q000098:blood supply* / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000098:blood supply* / Q000473:pathology; D014185:Transplantation, Isogeneic; D014407:Tumor Cells, Cultured