Neuregulins and the shaping of synapses.
In developing and mature neural circuits, neural electrical activity controls the correct formation of connections and their state. Neuregulins (NRGs) mediate between the electrical neural activity and molecular components by regulating the expression of ion channel receptors or transmitter release in synapses. Furthermore, NRGs may be signaling factors involved in tuning locomotion or other higher functions by coordinating excitatory and inhibitory neurons.
Ozaki
M
M
Laboratory for Cellular Information Processing, Brain Science Institute, The Institute of Physical and Chemical Research, RIKEN, Wako-shi, Saitama, Japan. mozaki@postman.riken.go.jp
D000818:Animals; D002531:Cerebellum / Q000502:physiology; D066246:ErbB Receptors / Q000502:physiology; D006801:Humans; D009415:Nerve Net / Q000502:physiology; D009422:Nervous System Diseases / Q000503:physiopathology / Q000628:therapy; D020880:Neuregulins / Q000502:physiology*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000502:physiology; D020893:Receptor, ErbB-3 / Q000502:physiology; D066247:Receptor, ErbB-4; D013569:Synapses / Q000502:physiology*
D066246:ErbB Receptors; D020880:Neuregulins; D018719:Erb-b2 Receptor Tyrosine Kinases; D020893:Receptor, ErbB-3; D066247:Receptor, ErbB-4; C587689:ERBB4 protein, human