title: Sinocranial aspergillosis: a form of central nervous system aspergillosis in south India.
abstract: Of the 21 patients with aspergillosis of central nervous system seen during the years 1990-1997, 16 (76%) had aspergillosis of sino-cranial origin. The occupation in patients with sino-cranial aspergillosis was either agricultural or manual work and predisposing risk factors were present in only two (12.5%) patients. Skull-base syndromes were the presenting features in 13 patients and three patients presented with features of intracranial space-occupying lesion. Paranasal sinus mass lesions were seen in all the 16 patients. Computerized tomography showed intracranial extradural-enhancing mass lesions in the anterior, middle or posterior cranial fossa in nine (68%) patients, intracranial and orbital lesions in four and orbital lesions in three. Well-formed granuloma with dense fibrosis was the histological feature. Survival rates were not good even after surgical and antifungal chemotherapy. Surgical treatment was subradical in our series. The majority of cases of sinocranial aspergillosis are reported from countries with temperate climates and the high incidence in these regions is probably related to constant exposure to the high spore content of pathogenic Aspergillus species in the 'mouldy' work environment.
authors.affiliation: Department of Neurology, Nizam's Institute of Medical Sciences, Punjagutta, Hyderabad 500 082, India.
authors.forename: J M
authors.initials: JM
authors.lastname: Murthy
authors.forename: C
authors.initials: C
authors.lastname: Sundaram
authors.forename: V S
authors.initials: VS
authors.lastname: Prasad
authors.forename: A K
authors.initials: AK
authors.lastname: Purohit
authors.forename: S
authors.initials: S
authors.lastname: Rammurti
authors.forename: V
authors.initials: V
authors.lastname: Laxmi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D001230:Aspergillus / Q000472:pathogenicity*; D001706:Biopsy; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000382:microbiology; D020314:Central Nervous System Fungal Infections / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D002980:Climate; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006099:Granuloma / Q000000981:diagnostic imaging / Q000382:microbiology; D006801:Humans; D007194:India / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D009916:Orbital Diseases / Q000000981:diagnostic imaging / Q000382:microbiology; D012307:Risk Factors; D012852:Sinusitis / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000453:epidemiology / Q000382:microbiology*; D014057:Tomography, X-Ray Computed
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B; D005437:Flucytosine