Polymorphism of CCR5 affecting HIV disease progression in the Japanese population.
Among several factors associated with HIV-1 disease progression, genetic polymorphism of CCR2, CCR5, and CXCR4 in HIV-1 infection has been found. Single-nucleotide polymorphisms (SNPs) in the CCR2, CCR5, and CXCR4 genes as well as a 32-base pair deletion in the open reading frame of the CCR5 gene are associated with HIV disease progression among Caucasians and African-Americans in North America and Europe. However, in populations other than Caucasians and African-Americans, SNPs have not been fully examined. In our study SNPs in CCR2 coding and CCR5 regulatory regions have been examined in 98 Japanese HIV-positive individuals. The alleles of CCR5 regulatory regions at -2135T and -2086G are associated with late onset of AIDS (p < 0.05; odds ratio for the early onset of AIDS, 0.502 and 0.404, respectively). In contrast to this, the allele of CCR5 at -2086A is associated with the early onset of AIDS (p < 0.05; odds ratio for the early onset of AIDS, 2.133). A haplotype including two alleles at -2135G and -2086G is associated with the late onset of AIDS (p < 0.05; odds ratio for the early onset of AIDS, 0.372). Thus we found that a CCR5 SNP and haplotype polymorphism affect HIV disease progression even in the Japanese population. This indicates that the CCR5 genetic polymorphism affecting disease progression should be studied in a wider range of population.
Kageyama
S
S
Department of Virology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930-0194, Japan. kageyama@compass.com.ph
Mimaya
J
J
Yamada
K
K
Kurimura
T
T
Shiraki
K
K
D000483:Alleles; D018450:Disease Progression; D008040:Genetic Linkage; D015658:HIV Infections / Q000235:genetics* / Q000276:immunology; D006679:HIV Seropositivity; D015497:HIV-1; D006239:Haplotypes; D006467:Hemophilia A / Q000235:genetics / Q000276:immunology / Q000821:virology; D006801:Humans; D007564:Japan; D011110:Polymorphism, Genetic / Q000235:genetics; D020641:Polymorphism, Single Nucleotide / Q000235:genetics*; D019713:Receptors, CCR5 / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid
D019713:Receptors, CCR5