title: Allogeneic stem cell transplantation reduces disease progression compared to autologous transplantation in patients with multiple myeloma.
abstract: This study compares the probability of disease progression, progression-free survival, and overall survival between patients undergoing an allogeneic or autologous transplant for multiple myeloma using an identical preparative regimen. Patients received a preparative regimen of TBI, busulfan, and cyclophosphamide followed by an allogeneic or autologous transplant. In the allogeneic group (n = 21), six patients received bone marrow and 15 received G-CSF mobilized PBSC; all autologous patients (n = 35) received PBSC mobilized with cyclophosphamide and G-CSF. Allogeneic donors were HLA-identical (n = 20) or one-antigen mismatched (n = 1) siblings. Graft-versus-host disease (GVHD) prophylaxis consisted of tacrolimus (n = 10), tacrolimus/methotrexate (n = 6), cyclosporine/methotrexate (n = 4), or cyclosporine (n = 1). The groups were evenly matched for gender, pretransplant therapy, disease status at time of transplant, myeloma subtype, and time from diagnosis to transplant. The median age was significantly lower in the allogeneic group (48 vs 55 years, P < 0.01). In the allogeneic group the probabilities of developing acute GVHD grade II-IV and chronic GVHD were 55% and 82%, respectively. The Kaplan-Meier probability of disease progression was significantly lower in the allogeneic group (11% vs 64%, P < 0.001) compared to the autologous group. Although progression-free (60% vs 30%, P = 0.19) and overall survival at 2 years (60% vs 42%, P = 0.39) favored the allogeneic group, this did not reach statistical significance. Within the allogeneic transplant group, patients age 50 years or under had a 3-year overall survival significantly higher when compared to older patients (79% vs 29%, P = 0.03). Using identical preparative regimens, allogeneic transplantation reduced disease progression compared to autologous transplantation for myeloma. This suggests that allogeneic transplantation induces a graft-versus-myeloma (GVM) effect.
authors.affiliation: Departments of Internal Medicine, Radiation-Oncology, and Biostatistics, University of Michigan Blood and Marrow Transplantation Program, Ann Arbor, MI, USA.
authors.forename: C
authors.initials: C
authors.lastname: Reynolds
authors.forename: V
authors.initials: V
authors.lastname: Ratanatharathorn
authors.forename: P
authors.initials: P
authors.lastname: Adams
authors.forename: T
authors.initials: T
authors.lastname: Braun
authors.forename: S
authors.initials: S
authors.lastname: Silver
authors.forename: L
authors.initials: L
authors.lastname: Ayash
authors.forename: E
authors.initials: E
authors.lastname: Carson
authors.forename: A
authors.initials: A
authors.lastname: Eisbruch
authors.forename: L A
authors.initials: LA
authors.lastname: Dawson
authors.forename: K
authors.initials: K
authors.lastname: McDonagh
authors.forename: J
authors.initials: J
authors.lastname: Ferrara
authors.forename: J
authors.initials: J
authors.lastname: Uberti
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D000368:Aged; D002423:Cause of Death; D018450:Disease Progression; D005260:Female; D006086:Graft vs Host Disease / Q000209:etiology; D020350:Graft vs Tumor Effect / Q000502:physiology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects / Q000379:methods / Q000592:standards*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000401:mortality / Q000628:therapy*; D016019:Survival Analysis; D014182:Transplantation, Autologous / Q000592:standards; D014184:Transplantation, Homologous / Q000592:standards; D016896:Treatment Outcome