Effect of high dose and low dose aspirin on survival of random pattern flaps in rats.
This paper studies which of the physiological effects of aspirin is responsible for increasing the survival of random flaps in rats, found in an earlier experiment. We wished to confirm that the antiaggregating--antithrombotic effect was responsible for the increased survival of flaps without microvascular anastomosis. Three groups of rats with standardised random pattern flaps were used. The first two were given aspirin 200 mg/kg (high dose, n = 27) or 40 mg/kg (low dose, n = 21) and the third (n = 28) acted as controls. The beneficial effects of aspirin were restricted to the high dose group. Since the low dose group also showed antiaggregation of platelets, but without the anti-inflammatory or vasodilatory effects, the results indicate that the antiaggregating effect alone was not responsible for the increased survival of the flaps.
Shalom
A
A
Department of Plastic Surgery, Assaf Harofeh Medical Center, Zerifin, Israel.
Westreich
M
M
D000704:Analysis of Variance; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000008:administration & dosage* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013524:Surgical Flaps
D010975:Platelet Aggregation Inhibitors; D001241:Aspirin