Treatment of neuroleptic malignant syndrome with subcutaneous apomorphine monotherapy.
A 20-year-old psychiatric patient receiving haloperidol treatment developed acute-onset fever, rigidity, and mental changes. Subcutaneous apomorphine was given alone for treatment. The patient had rapid clinical improvement after the treatment. Serial blood examinations showed decline and subsequent normalization of the creatine phosphokinase levels.
Wang
H C
HC
Department of Neurology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan. drhan@ms1.hinet.net
Hsieh
Y
Y
D000328:Adult; D001058:Apomorphine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D007279:Injections, Subcutaneous; D009459:Neuroleptic Malignant Syndrome / Q000188:drug therapy*; D009460:Neurologic Examination / Q000187:drug effects; D012559:Schizophrenia / Q000188:drug therapy; D014282:Trihexyphenidyl / Q000008:administration & dosage / Q000009:adverse effects
D014282:Trihexyphenidyl; D006220:Haloperidol; D001058:Apomorphine