CX3C chemokine mimicry by respiratory syncytial virus G glycoprotein.
Chemokines are chemoattractant proteins that are divided into subfamilies based upon cysteine signature motifs termed C, CC, CXC and CX3C. Chemokines have roles in immunity and inflammation that affect cell trafficking and activation of T cells as well as cells of the innate immune system. We report here CX3C chemokine mimicry for the G glycoprotein of respiratory syncytial virus (RSV) and show binding to CX3CR1--the specific receptor for the CX3C chemokine fractalkine--and induction of leukocyte chemotaxis. We also show that CX3CR1 facilitates RSV infection of cells. Thus, G glycoprotein interaction with CX3CR1 probably plays a key role in the biology of RSV infection.
Tripp
R A
RA
National Centers for Infectious Diseases, Division of Viral and Rickettsial Diseases, Respiratory and Enteric Virus Branch, Mailstop G-09, 1600 Clifton Rd., Atlanta, GA, USA. rgt3@cdc.gov
Jones
L P
LP
Haynes
L M
LM
Zheng
H
H
Murphy
P M
PM
Anderson
L J
LJ
D000818:Animals; D020523:Chemokines, CX3C / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D006023:Glycoproteins / Q000276:immunology; D007113:Immunity, Innate; D008213:Lymphocyte Activation; D051379:Mice; D008969:Molecular Sequence Data; D012136:Respiratory Syncytial Viruses / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014764:Viral Proteins / Q000276:immunology*
D020523:Chemokines, CX3C; D006023:Glycoproteins; D014764:Viral Proteins