title: [Primary orthostatic tremor: slow harmonic component as responsible of inestability].
abstract: BACKGROUND
  Orthostatic tremor (OT) is clinically defined as a tremor of the lower limbs and trunk on walking. It bears a significant functional impairement. Although the term orthostatic tremor was first used by Heilman in 1984, Pazzaglia et al had previously described some cases in 1970. Despite the fact that the pathophysiology of this entity is not fully known, the presence of a central oscillator is generally accepted as being responsible. A high frecuency tremor, between 13 and 18 Hz, constitutes an almost patognomonic finding, and treatment with clonazepam usually improves the symptoms.
  
  
  METHODS
  We present a patient who described his symptoms as "cramps" in lower limbs and trunk on standing up, which were relieved on walking or resting.
  
  
  RESULTS
  This clinical presentation together with a neurophysiological recording of the tremor showing an activity of lower frequency (8 Hz) combined with the usual higher frequency (16 Hz) and above all the clear amelioration of symptoms when treated with gabapentin, i.e. resolution of the low frequency tremor without changes in the 16 Hz tremor, were the peculiar features of this case which merits discussion.
  
  
  CONCLUSIONS
  The slow component of the orthostatic tremor is crucial in this case. The improvement with gabapentin is explained by the disappearance of this slow c
authors.affiliation: Neurofisiología. Hospital de Alarcos. Ciudad Real.
authors.forename: J
authors.initials: J
authors.lastname: Cano
authors.forename: B
authors.initials: B
authors.lastname: Catalán
authors.forename: R
authors.initials: R
authors.lastname: Ibáñez
authors.forename: M
authors.initials: M
authors.lastname: Gudín
authors.forename: A
authors.initials: A
authors.lastname: Hernández
authors.forename: J
authors.initials: J
authors.lastname: Vaamonde
mesh_terms: D000085:Acetates / Q000627:therapeutic use; D000588:Amines; D002998:Clonazepam / Q000627:therapeutic use; D003509:Cyclohexanecarboxylic Acids; D004576:Electromyography; D018757:GABA Modulators / Q000627:therapeutic use; D000077206:Gabapentin; D006801:Humans; D008297:Male; D008875:Middle Aged; D010507:Periodicity; D011187:Posture / Q000502:physiology*; D014202:Tremor / Q000188:drug therapy / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid
chemical_list: D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D018757:GABA Modulators; D005680:gamma-Aminobutyric Acid; D002998:Clonazepam; D000077206:Gabapentin