Protein synthesis. The perks of balancing glucose.
What do the regulation of translation initiation and glucose metabolism have to do with each other? Quite a lot, it seems, according to Sonenberg and Newgard in their Perspective. They discuss new findings that identify the kinase responsible for inactivating eIF2--a factor that is required for translation initiation (and hence protein synthesis)--when the endoplasmic reticulum is under stress. Loss of this kinase results in destruction of insulin-producing b cells in the pancreas and dysregulation of glucose homeostasis.
Sonenberg
N
N
Newgard
C B
CB
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000378:metabolism*; D015852:Eukaryotic Initiation Factor-2 / Q000378:metabolism*; D005943:Gluconeogenesis; D005947:Glucose / Q000378:metabolism*; D006706:Homeostasis; D006943:Hyperglycemia / Q000209:etiology; D007003:Hypoglycemia / Q000209:etiology; D007515:Islets of Langerhans / Q000201:enzymology / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D009154:Mutation; D010766:Phosphorylation; D014176:Protein Biosynthesis; D017510:Protein Folding; D019892:eIF-2 Kinase / Q000378:metabolism*
D001786:Blood Glucose; D015852:Eukaryotic Initiation Factor-2; D005947:Glucose; D019892:eIF-2 Kinase