No association between a promoter dopamine D(4) receptor gene variant and schizophrenia.
The dopamine D(4) receptor has been implicated in the pathogenesis of schizophrenia. An association between a putative functional promoter polymorphism (-521C/T) in the dopamine D(4) receptor gene (DRD4) and schizophrenia was recently reported. In the present study, patients with schizophrenia (n = 132) and control subjects (n = 388) were analyzed with respect to the DRD4 - 521C/T polymorphism. No significant case control differences emerged. The present results do not support a major role for DRD4 in the etiology of schizophrenia among Caucasians from Sweden.
Jönsson
E G
EG
Department of Clinical Neuroscience, Psychiatry Section, Karolinska Institute, SE-171, 76 Stockholm, Sweden. erikj@psyk.ks.se
Ivo
R
R
Forslund
K
K
Mattila-Evenden
M
M
Rylander
G
G
Cichon
S
S
Propping
P
P
Nöthen
M M
MM
Asberg
M
M
Sedvall
G C
GC
D000328:Adult; D000483:Alleles; D004247:DNA / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017448:Receptors, Dopamine D2 / Q000235:genetics*; D050638:Receptors, Dopamine D4; D012559:Schizophrenia / Q000235:genetics*
C493599:DRD4 protein, human; D017448:Receptors, Dopamine D2; D050638:Receptors, Dopamine D4; D004247:DNA