title: Evaluation of hydrogen bonding complementarity between a secondary sulfonamide and an alpha-amino acid residue.
abstract: [structure: see text] We report an initial step toward the development of sulfonamide-based complements for extended peptide strands. A molecule containing one secondary sulfonamide unit and one valine residue linked by a turn-forming segment was found by IR and NMR to exhibit a doubly hydrogen-bonded folding pattern in chloroform.
authors.affiliation: Department of Chemistry and Graduate Program in Biophysics, University of Wisconsin, Madison, WI 53706, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Langenhan
authors.forename: J D
authors.initials: JD
authors.lastname: Fisk
authors.forename: S H
authors.initials: SH
authors.lastname: Gellman
mesh_terms: D000596:Amino Acids / Q000737:chemistry*; D000890:Anti-Infective Agents / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D013055:Spectrophotometry, Infrared; D013449:Sulfonamides / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D000890:Anti-Infective Agents; D013449:Sulfonamides