Measurement of covalent drug-DNA interactions at the nucleotide level in cells at pharmacologically relevant doses.
McGurk
C J
CJ
CRC Drug-DNA Interactions Research Group, Royal Free and University College Medical School, University College London, London W1P 8BT, United Kingdom.
McHugh
P J
PJ
Tilby
M J
MJ
Grimaldi
K A
KA
Hartley
J A
JA
D000970:Antineoplastic Agents / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D018736:DNA Adducts / Q000032:analysis*; D004249:DNA Damage; D017931:DNA Primers / Q000235:genetics; D004273:DNA, Neoplasm / Q000737:chemistry / Q000187:drug effects / Q000235:genetics / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D016133:Polymerase Chain Reaction / Q000379:methods*
D000970:Antineoplastic Agents; D018736:DNA Adducts; D017931:DNA Primers; D004273:DNA, Neoplasm; D004247:DNA