title: [High-volume hemodiafiltration in the treatment of sepsis and multiple organ failure: 2 methods of the elimination of TNF-alpha].
abstract: Permanent hemodiafiltration (PHDF) as a method for treating patients with sepsis and multiple organ failure (MOF) corrects the severity of generalized inflammatory reaction, which is caused by hyperproduction of bioactive substances. Cytokines can be eliminated from circulation by 2 methods of kidney-replacing therapy: convection and adsorption on hemofilter membrane. Despite the slight adsorption clearance, our results indicate that experimental data not always correspond to the clinical situation. Pronounced cytokinemia persists in patients with sepsis and MOF during PHDF. In addition to correction of the main hemostasis parameters, kidney-replacing therapy eliminates an appreciable amount of TNF-alpha and other proinflammatory cytokines. Estimation of TNF-alpha balance indicates its good adsorption on the surface of hemodiafilter membrane.
authors.forename: I I
authors.initials: II
authors.lastname: Iakovleva
authors.forename: V S
authors.initials: VS
authors.lastname: Timokhov
authors.forename: G V
authors.initials: GV
authors.lastname: Lialikova
authors.forename: E V
authors.initials: EV
authors.lastname: Pestriakov
authors.forename: V V
authors.initials: VV
authors.lastname: Moroz
authors.forename: O B
authors.initials: OB
authors.lastname: Mura'ev
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Sergeev
mesh_terms: D000328:Adult; D003627:Data Interpretation, Statistical; D005260:Female; D017583:Hemodiafiltration / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000097:blood / Q000628:therapy*; D018805:Sepsis / Q000097:blood / Q000628:therapy*; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*
chemical_list: D014409:Tumor Necrosis Factor-alpha