A hospital-based multicentric study results on gestational trophoblastic disease management status in a developing country.
OBJECTIVE
To determine the clinical management of gestational trophoblastic disease in Turkey.


METHODS
An inquiry form was sent to 55 health centers including university hospitals, maternity hospitals with residency programs and maternity hospitals without residency programs in 1997. The inquiry consisted of questions about the type of classification systems in use, distribution of cases according to those classifications, use of prophylactic chemotherapy and its indications, and drug preference for single-agent or combined chemotherapies.


RESULTS
The overall response rate to the conducted inquiry was 47.1%. A clinical classification system was identified in 60% of the hospitals in Turkey. Generally, methotrexate was the most used single-agent chemotherapy. With regard to first-line combined chemotherapy, MAC (methotrexate, antinomycin-D, cyclophosphamide) was the preferred combination. EMA-CO (etoposide, methotrexate, actinomycin-D, cyclophosphamide, vincristine) was the most common used second-line chemotherapeutic regimen.


CONCLUSIONS
Due to insufficient data acquisition from all the medical centers and a lack of national population-based studies, it is difficult to draw a conclusion with respect to the interpretation of the data about the management protocols of gestational trophoblastic disease.
Ozalp
S S
SS
Department of Obstetrics and Gynecology, Osmangazi University Faculty of Medicine, Eski ehir, Turkey.
Yalçin
O T
OT
Tanir
H M
HM
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006302:Health Services Research; D006761:Hospitals / Q000592:standards* / Q000706:statistics & numerical data; D006771:Hospitals, Maternity / Q000592:standards / Q000706:statistics & numerical data; D006785:Hospitals, University / Q000592:standards / Q000706:statistics & numerical data; D006801:Humans; D017410:Practice Guidelines as Topic; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D014421:Turkey; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000188:drug therapy*
D000970:Antineoplastic Agents