title: Improving the accuracy of vascular testing in impotent men: correcting hemodynamic alterations using a vasoactive medication re-dosing schedule.
abstract: OBJECTIVE
  Arteriogenic or venogenic vascular insufficiency is the most common pathophysiology of organic erectile dysfunction. While vascular insufficiency may be suspected on history and physical examination, the definitive diagnosis is made by vascular testing. Dynamic infusion cavernosometry is a recognized technique for evaluating the hemodynamics of erection. Assigning the correct vascular diagnosis during testing is important. Complete corporeal smooth muscle relaxation is essential for obtaining accurate data. Previously others have suggested that repeat dosing with vasoactive medication may improve the diagnostic accuracy of vascular testing. We investigated the hemodynamic effect of repeat doses of medication.
  
  
  METHODS
  Data were prospectively obtained on men undergoing dynamic infusion cavernosometry. When veno-occlusive parameters were abnormal, the intracavernous vasoactive agent dose was repeated to a maximum of 3 doses. Standard dynamic infusion cavernosometry criteria were used for diagnosing arteriogenic and venogenic erectile dysfunction. We analyzed the proportion of men in whom the vascular diagnosis was altered using this regimen.
  
  
  RESULTS
  Of 420 men undergoing dynamic infusion cavernosometry, 70% warranted re-dosing based on abnormal veno-occlusive parameters. Of these 294 men veno-occlusive values were corrected by repeat medication in 32% and, therefore, they would have been falsely diagnosed with venous leakage during vascular evaluation. Half of all corrections occurred with the second dose, while half of the patients required a third dose of medication.
  
  
  CONCLUSIONS
  These data should encourage clinicians to consider re-dosing during the vascular evaluation of men in whom incomplete corporeal smooth muscle relaxation is suspected. In this way a false diagnosis of venous leakage may be avoided in a significant number of cases.
authors.affiliation: Loyola University Medical Center, Stritch School of Medicine, Boston, Massachusetts, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Mulhall
authors.forename: A
authors.initials: A
authors.lastname: Abdel-Moneim
authors.forename: R
authors.initials: R
authors.lastname: Abobakr
authors.forename: I
authors.initials: I
authors.lastname: Goldstein
mesh_terms: D000328:Adult; D006439:Hemodynamics; D006801:Humans; D018783:Impotence, Vasculogenic / Q000175:diagnosis* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010208:Papaverine; D010646:Phentolamine / Q000008:administration & dosage*; D011446:Prospective Studies; D015203:Reproducibility of Results; D014665:Vasodilator Agents / Q000008:administration & dosage*
chemical_list: D014665:Vasodilator Agents; D010208:Papaverine; D010646:Phentolamine