title: A prospective natural history study of inclusion body myositis: implications for clinical trials.
abstract: Eleven patients with untreated inclusion body myositis (IBM) were prospectively studied during a 6-month period that included muscle strength, lean body mass, and muscle mass measurements. There was an overall quantifiable mean decline in percent of predicted normal muscle strength of 4% from baseline in a 6-month period, but one third of patients showed no change or slight improvements in strength. Short-term treatment trials in IBM will require large numbers of patients to detect slowing, arrest, or even slight improvement in muscle strength.
authors.affiliation: Department of Neurology, King's Neurosciences Centre, King's College Hospital, London, UK. m.r.rose@kcl.ac.uk
authors.forename: M R
authors.initials: MR
authors.lastname: Rose
authors.forename: M P
authors.initials: MP
authors.lastname: McDermott
authors.forename: C A
authors.initials: CA
authors.lastname: Thornton
authors.forename: C
authors.initials: C
authors.lastname: Palenski
authors.forename: W B
authors.initials: WB
authors.lastname: Martens
authors.forename: R C
authors.initials: RC
authors.lastname: Griggs
mesh_terms: D000368:Aged; D002986:Clinical Trials as Topic; D018450:Disease Progression; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018979:Myositis, Inclusion Body / Q000503:physiopathology*