Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination--possible markers for an antibody-mediated process.
The present report describes immunopathological, radiologcal and serological characteristics of antibody-mediated demyelination in a multiple sclerosis (MS) case with the main findings: (1) immunoglobulin and complement deposits in areas of active demyelination accompanied by massive macrophage activation; (2) ring-enhancing lesions in T1-weighted MRI after gadolinium application; (3) high titers of serum anti-myelin antibodies; and (4) signs of macrophage activation in the serum. Plasmapheresis may be a successful treatment for the type of inflammatory demyelination shown in the present case.
Brück
W
W
Department of Neuropathology, Charité, Humboldt-Universität, Berlin, Germany.
Neubert
K
K
Berger
T
T
Weber
J R
JR
D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers; D002490:Central Nervous System / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D003711:Demyelinating Diseases / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology*; D009185:Myelin Proteins / Q000276:immunology; D010956:Plasmapheresis; D011859:Radiography
D001323:Autoantibodies; D015415:Biomarkers; D009185:Myelin Proteins