Anticlastogenic effects of d- and l-centchroman in Swiss albino mice. 2. Subacute study in vivo and comparison with tamoxifen.
The antimutagenic effects of the two enantiomers of centchroman, a nonsteroidal oral contraceptive, were evaluated and compared with tamoxifen, a known breast cancer drug. Anticlastogenic assays in subacute in vivo studies in Swiss albino mice were used. They revealed that both d-centchroman and I-centchroman reduced the chromosome aberrations produced by dimethylbenz(a)anthracene and cyclophosphamide, when compared with the group treated only with the former mutagen. Tamoxifen also reduced the chromosome aberrations produced by the two mutagens. Overall the results showed that l-centchroman alone was more effective in reducing cyclophosphamide-induced aberrations than d-centchroman, and for toxicity reasons may be an alternative to tamoxifen in breast cancer therapy.
Mukhopadhyay
A
A
Indian Institute of Chemical Biology, Jadavpur, Calcutta.
Ray
S
S
Giri
A K
AK
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology; D001854:Bone Marrow Cells / Q000187:drug effects; D002486:Centchroman / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology*; D002869:Chromosome Aberrations / Q000187:drug effects*; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors; D005260:Female; D051379:Mice; D013237:Stereoisomerism; D013629:Tamoxifen / Q000494:pharmacology*
D016587:Antimutagenic Agents; D000970:Antineoplastic Agents; D013629:Tamoxifen; D002486:Centchroman; D015127:9,10-Dimethyl-1,2-benzanthracene; D003520:Cyclophosphamide