title: Nonlinear focusing of DNA macromolecules.
abstract: The present paper reports the nonlinear electrophoretic focusing techniques developed after an original idea by Chacron and Slater [Phys. Rev. E 56, 3436 (1997)]. Focusing of DNA molecules is achieved in an alternating nonuniform electric field, created in a wedge gel with hyperbolic boundaries. The fractions separated on such a wedge retained their rectilinear shape during the electrophoresis. Experiments with gel electrophoresis confirm the possibility of a noticeable nonlinear focusing of DNA molecules.
authors.affiliation: Proteologics (Israel) Ltd., Weizmann Science Park, Building Lev HaPark, 5 Oppenheimer Street, Rehovot, 76701, Israel.
authors.forename: L L
authors.initials: LL
authors.lastname: Frumin
authors.forename: S E
authors.initials: SE
authors.lastname: Peltek
authors.forename: G V
authors.initials: GV
authors.lastname: Zilberstein
mesh_terms: D010582:Bacteriophage lambda / Q000737:chemistry / Q000235:genetics; D003198:Computer Simulation; D004247:DNA / Q000737:chemistry* / Q000302:isolation & purification / Q000528:radiation effects*; D004279:DNA, Viral / Q000737:chemistry / Q000302:isolation & purification / Q000528:radiation effects; D004563:Electrochemistry / Q000379:methods; D004574:Electromagnetic Fields; D015180:Electrophoresis, Gel, Two-Dimensional / Q000379:methods*; D008956:Models, Chemical; D008958:Models, Molecular; D017711:Nonlinear Dynamics; D012680:Sensitivity and Specificity
chemical_list: D004279:DNA, Viral; D004247:DNA