title: Estrogen use and brain metabolic change in older adults. A preliminary report.
abstract: Because estrogen may influence brain blood flow and metabolism in older adults, we used positron emission tomography to evaluate cerebral glucose metabolic change in post-menopausal women and men. Women estrogen users (n=4), women non-users (n=8) and men (n=10) were scanned at baseline and two years later. Analyses focused on glucose metabolism in lateral temporal, inferior parietal and posterior cingulate brain regions, previously reported to decline in non-demented older persons. No metabolic differences in cerebral regions of interest were found among groups at baseline. At follow-up, women estrogen users showed significantly increased glucose metabolism in the lateral temporal region, whereas women non-users and men exhibited no significant metabolic change in this region. These findings suggest that estrogen use may protect against regional cerebral metabolic decline in postmenopausal women.
authors.affiliation: Department of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, the Neuropsychiatric Institute, Los Angeles, CA 90095, USA. nrasgon@mednet.ucla.edu
authors.forename: N L
authors.initials: NL
authors.lastname: Rasgon
authors.forename: G W
authors.initials: GW
authors.lastname: Small
authors.forename: P
authors.initials: P
authors.lastname: Siddarth
authors.forename: K
authors.initials: K
authors.lastname: Miller
authors.forename: L M
authors.initials: LM
authors.lastname: Ercoli
authors.forename: S Y
authors.initials: SY
authors.lastname: Bookheimer
authors.forename: H
authors.initials: H
authors.lastname: Lavretsky
authors.forename: S C
authors.initials: SC
authors.lastname: Huang
authors.forename: J R
authors.initials: JR
authors.lastname: Barrio
authors.forename: M E
authors.initials: ME
authors.lastname: Phelps
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000187:drug effects* / Q000378:metabolism*; D000704:Analysis of Variance; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000627:therapeutic use*; D005260:Female; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D019275:Radiopharmaceuticals; D013702:Temporal Lobe / Q000378:metabolism; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome
chemical_list: D004967:Estrogens; D019275:Radiopharmaceuticals; D019788:Fluorodeoxyglucose F18