title: Risk factors for emergence of resistance to broad-spectrum cephalosporins among Enterobacter spp.
abstract: Among 477 patients with susceptible Enterobacter spp., 49 subsequently harbored third-generation cephalosporin-resistant Enterobacter spp. Broad-spectrum cephalosporins were independent risk factors for resistance (relative risk [OR] = 2.3, P = 0.01); quinolone therapy was protective (OR = 0.4, P = 0.03). There were trends toward decreased risk for resistance among patients receiving broad-spectrum cephalosporins and either aminoglycosides or imipenem. Of the patients receiving broad-spectrum cephalosporins, 19% developed resistance.
authors.affiliation: Division of Infectious Diseases and Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: K S
authors.initials: KS
authors.lastname: Kaye
authors.forename: S
authors.initials: S
authors.lastname: Cosgrove
authors.forename: A
authors.initials: A
authors.lastname: Harris
authors.forename: G M
authors.initials: GM
authors.lastname: Eliopoulos
authors.forename: Y
authors.initials: Y
authors.lastname: Carmeli
mesh_terms: D016470:Bacteremia / Q000188:drug therapy / Q000382:microbiology; D018550:Cephalosporin Resistance / Q000502:physiology*; D002511:Cephalosporins / Q000627:therapeutic use; D015331:Cohort Studies; D004363:Drug Utilization; D004754:Enterobacter / Q000502:physiology*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
chemical_list: D002511:Cephalosporins