Effects of subinhibitory concentrations of nitroxoline on the surface properties of Escherichia coli.
Nitroxoline (5-nitro-8-quinolinol; NIQ) at subinhibitory concentrations (sub-MIC) decreased the adherence of uropathogenic Escherichia coli to catheter surface and significantly enhanced cell surface hydrophobicity. The surface hydrophobicity increased in the presence of sub-MIC of NIQ and also in an excess of Mg2+. The effect of NIQ on the cell surface was not related to the bacteriostatic effect of this agent. The increase in nitrogen and decrease in phosphate content in the cell surface was found in the presence of NIQ. NIQ did not inhibit the expression of fimbriae.
Latrache
H
H
Laboratoire de Microbiologie, Faculté de Pharmacie, Université Paris XI, 92 296 Chátenay-Malabry, France.
Bourlioux
P
P
Karroua
M
M
Zahir
H
H
Hakkou
A
A
D001422:Bacterial Adhesion / Q000187:drug effects; D002462:Cell Membrane / Q000737:chemistry / Q000187:drug effects / Q000648:ultrastructure; D004926:Escherichia coli / Q000737:chemistry / Q000187:drug effects* / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D009600:Nitroquinolines / Q000008:administration & dosage / Q000494:pharmacology*; D013499:Surface Properties; D014546:Urinary Catheterization / Q000009:adverse effects; D014552:Urinary Tract Infections / Q000188:drug therapy / Q000209:etiology
D009600:Nitroquinolines; C005308:nitroxoline