Effectiveness of Thai cobra (Naja kaouthia) antivenom against sea snake (Lapemis hardwickii) venom: verification by affinity purified F(AB')2 fragments.
Commercial Thai cobra (Naja kaouthia) antivenom was found to be effective in neutralizing sea snake (Lapemis hardwickii) venom. Neurotoxin specific F(ab')2 fragments obtained from the antivenom by chromatography using Thai cobra neurotoxin or sea snake venom affinity columns were able to neutralize both venoms.
Khow
O
O
Queen Saovabha Memorial Institute, Thai Red Cross Society, Bangkok, Thailand.
Chanhome
L
L
Omori-Satoh
T
T
Sitprija
V
V
D000818:Animals; D000997:Antivenins / Q000737:chemistry / Q000494:pharmacology*; D004546:Elapid Venoms / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D017815:Elapidae; D005779:Immunodiffusion; D007928:Lethal Dose 50; D051379:Mice; D010446:Peptide Fragments / Q000737:chemistry; D018675:Toxicity Tests
D000997:Antivenins; D004546:Elapid Venoms; D010446:Peptide Fragments