title: ClC chloride channels in epithelia: recent progress and remaining puzzles.
abstract: ClC chloride channels are widely expressed in epithelia. Recent insights into the roles of specific ClC channels have emerged from molecular and immunolocalization studies, mouse knockout models, and the linkage of mutations of these channels to the human hereditary diseases Bartter's syndrome and Dent's disease.
authors.affiliation: Department of Physiology and Biophysics, University of Texas Medical Branch, Galveston, Texas 77551, USA.
authors.forename: N K
authors.initials: NK
authors.lastname: Wills
authors.forename: P
authors.initials: P
authors.lastname: Fong
mesh_terms: D000818:Animals; D001477:Bartter Syndrome / Q000235:genetics; D018118:Chloride Channels / Q000235:genetics / Q000502:physiology*; D004847:Epithelial Cells / Q000378:metabolism*; D008040:Genetic Linkage; D007674:Kidney Diseases / Q000235:genetics; D007687:Kidney Tubules, Proximal; D005810:Multigene Family; D009154:Mutation; D010827:Physiology / Q000639:trends; D014018:Tissue Distribution
chemical_list: D018118:Chloride Channels