[Treatment with LHRH analogues in girls with precocious puberty does not improve final height. Longitudinal study compared with a control group].
BACKGROUND
We analysed the effectiveness of therapy with LHRH analogues in girls with a puberty onset at age 8 years.


METHODS
We performed a non-randomised clinical study of 32 girls with advanced puberty. These included 16 treated with triptorelin LHRH analogue(3.75 mg/month during 1 year) and 16 control subjects. We carried out anthropometric measurements and determined the pubertal height growth (gain in height from the puberty onset up to the final height) and the pubertal duration (time in years from the puberty onset up to the age at which final height is attained).


RESULTS
Treatment with LHRH analogue delayed the menarche age (11.5 [1.46]vs 10.37 [0.67] years of age; p = 0.03), led to an involution in secondary sexual characteristics and a temporary decrease ingrowth rate, and delayed skeletal maturation. However, pubertal duration, pubertal height growth and final height were all similar in both groups. In addition, no significant differences in body fat mass were observed.


CONCLUSIONS
Treatment with LHRH analogues in advanced puberty modifies pubertal development, without modifying pubertal duration or pubertal height growth. Furthermore, this treatment does not improve final height.
Llop-Viñolas
D
D
Grupo de Investigación en Alimentación, Nutrición, Crecimiento y Salud Mental. Unidad de Pediatría. Hospital Universitario Sant Joan de Reus. Facultad de Medicina y Ciencias de la Salud. Universidad Rovira i Virgili.
Vizmanos-Lamotte
B
B
Aresté-Piztzalis
A
A
Fernández-Ballart
J
J
Martí-Henneberg
C
C
D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D002648:Child; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D008137:Longitudinal Studies; D011629:Puberty, Precocious / Q000188:drug therapy*; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone