title: Serum calcium response following oral zinc oxide administrations in dairy cows.
abstract: Six non-pregnant cows were allocated into 3 groups. Group 1 comprised a pair of lactating cows, whereas groups 2 and 3 each comprised a pair of non-lactating cows. The cows in groups 1 and 2 were dosed intraruminally by stomach tube with zinc oxide at 120 mg Zn per kg of bodyweight at weekly intervals for a period of 33 days. Each cow received a total of 4 doses of zinc oxide. Group 3 served as non-treated control group. Blood samples were collected from all 6 cows daily. Serum was analysed for concentration of calcium. Within 12-24 h of each zinc oxide administration the serum calcium of the lactating cows dropped dramatically indicating the existence of an antagonistic effect between Zn and Ca. The first Zn induced hypocalcaemic episode in the lactating cows was followed by a rise in serum calcium to a level above the pre-dosing level and above the mean value of the control group. The depth of the hypocalcaemic response decreased with the number of zinc oxide dosings. This effect was explained as a response from the stimulation of the calcium homeostatic mechanisms. In the Zn dosed non-lactating cows responses were similar but less clear. The perspective of these findings is discussed in relation to resistance towards parturient hypocalcaemia.
authors.affiliation: Royal Veterinary and Agricultural University, Department of Clinical Studies, Cattle Production Medicine Research Group, Denmark. trh@kvl.dk
authors.forename: T
authors.initials: T
authors.lastname: Thilsing-Hansen
authors.forename: R J
authors.initials: RJ
authors.lastname: Jørgensen
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002118:Calcium / Q000097:blood*; D002136:Calcium, Dietary / Q000008:administration & dosage; D002417:Cattle; D005260:Female; D006996:Hypocalcemia / Q000139:chemically induced / Q000378:metabolism*; D007774:Lactation / Q000378:metabolism*; D015034:Zinc Oxide / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D002136:Calcium, Dietary; D015034:Zinc Oxide; D002118:Calcium