title: Skin sympathetic outflow in Buerger's disease.
abstract: To clarify if sympathetic outflow is altered in Buerger's disease (thromboangitis obliterans, TAO), we measured skin sympathetic nerve activity (SSNA) in TAO patients, and observed the sweating and vasoconstrictive responses during resting and with activating maneuvers. Multiunit postganglionic sympathetic activity was recorded in a skin fascicle of the tibial nerve innervating the skin of the sole (glabrous skin) and peroneal nerve innervating the skin of the dorsum pedis (hairy skin) from five TAO patients and five healthy subjects simultaneously with skin blood flow and sweat expulsion. TAO patients showed significantly less vasoconstrictor SSNA than healthy subjects (17.0+/-1.9 vs. 31.5+/-5.8 bursts/min, P<0.001). Moreover, we found no relationship between vasoconstrictor SSNA and skin blood flow in some patients, while they were well correlated in healthy subjects. There was no evidence for increased sympathetic activity in TAO patients, and no hypersensitive relationship was found between SSNA and skin blood flow. These observations suggested that these TAO patients exhibiting no relationship between skin blood flow reduction and vasoconstrictor activity might not respond to sympathectomy, which is generally expected to result in an increase in skin blood flow. The absence of increased sympathetic nerve activity provides further indirect evidence of a local vascular abnormality in TAO.
authors.affiliation: Department of Autonomic Neuroscience, Nagoya University, Japan. iwase@riem.nagoya-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Iwase
authors.forename: T
authors.initials: T
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Mano
authors.forename: A
authors.initials: A
authors.lastname: Kamiya
authors.forename: Y
authors.initials: Y
authors.lastname: Niimi
authors.forename: F
authors.initials: F
authors.lastname: Qi
authors.forename: N
authors.initials: N
authors.lastname: Nishikimi
authors.forename: T
authors.initials: T
authors.lastname: Sakurai
authors.forename: Y
authors.initials: Y
authors.lastname: Nimura
mesh_terms: D000328:Adult; D006801:Humans; D017078:Laser-Doppler Flowmetry; D008297:Male; D008875:Middle Aged; D010543:Peroneal Nerve / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D012867:Skin / Q000098:blood supply / Q000294:innervation*; D013545:Sweat Glands / Q000294:innervation / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology*; D013919:Thromboangiitis Obliterans / Q000503:physiopathology*; D013979:Tibial Nerve / Q000502:physiology; D014661:Vasoconstriction / Q000502:physiology