[Influence of ligustrazine-contained peritoneal dialysate on efficiency of dialysis].
OBJECTIVE
To observe the influence of ligustrazine on efficiency of peritoneal dialysis.


METHODS
A prospective, self-controlled study was adopted, 24 stable continuous ambulatory peritoneal dialysis (CAPD) patients were divided into 4 groups according to their peritoneal membrane solute transport types identified by peritoneal equilibration test (PET), the high transport group (H group, 4 cases), the high-average transport group (Ha group, 11 cases), the low-average transport group (La group, 8 cases) and the low transport group (L group, 1 case). After treated with standard dialysis for 2 weeks, patients were treated by peritoneal dialysis with ligustrazine (240 mg/d) contained dialysate for another 2 weeks, and changes on mean net ultrafiltration volume (UF) per exchange, and urea kinetics (KT/V) per week of patients were observed.


RESULTS
After ligustrazine treatment, the UF and KT/V raised significantly, P < 0.01. In comparison of groups with different transportation, except change on UF of the H group was insignificant, increment of both parameters before and after treatment were significant (P < 0.01 or 0.05).


CONCLUSIONS
By adding ligustrazine in standard dialysate can enhance the efficiency of peritoneal dialysis, raise the UF, so is worth further study.
Lu
C
C
Institute of Kidney, First Affiliated Hospital of Sun Yat-sen University of Medical Sciences, Guangzhou 510080.
Ye
R
R
Sun
L
L
D000328:Adult; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000379:methods*; D011446:Prospective Studies; D011719:Pyrazines / Q000627:therapeutic use*; D014462:Ultrafiltration
D011719:Pyrazines; C017953:tetramethylpyrazine