title: Herpesvirus type 1-8 in sinus aspirates from HIV-infected patients and immunocompetent individuals.
abstract: Sinusitis is frequently occurring in HIV-infected patients, but in a substantial number of cases the etiology is unknown. The purpose of this study was by PCR 1) to determine the prevalence of the eight human herpesviruses in sinus aspirates from 24 HIV-positive/AIDS patients with sinusitis 2) to relate the presence of herpesvirus DNA to clinical and immunological parameters and 3) to compare the prevalence of herpesvirus DNA in sinus aspirates from HIV-infected patients with the prevalence observed in 50 immunocompetent patients with sinusitis. DNA from HSV-1, EBV, CMV and HHV-8 was detected in 8 (33%) of the sinus aspirates from HIV-infected patients. In the immunocompetent patients, one of the herpesviruses, HHV-6, was found in one sinus aspirate. These data indicate that herpesviruses are frequently found in sinus aspirates from HIV-infected patients with sinusitis, whereas they do not seem to be related to clinical signs of sinusitis in immunocompetent individuals. The cause of these discrepancies may be due to uncontrolled reactivation of herpesviruses, which is known to occur in immunocompromised individuals. It remains to be established whether the herpesviruses play a pathogenic role in the development of sinusitis in HIV-infected patients.
authors.affiliation: Department of Infectious Diseases, Marselisborg Hospital, Aarhus University Hospital, DK-8000 Aarhus C, Denmark. tarp@aaa.dk
authors.forename: B
authors.initials: B
authors.lastname: Tarp
authors.forename: J
authors.initials: J
authors.lastname: Kelsen
authors.forename: L P
authors.initials: LP
authors.lastname: Nielsen
authors.forename: B
authors.initials: B
authors.lastname: Vinther
authors.forename: N
authors.initials: N
authors.lastname: Obel
mesh_terms: D000328:Adult; D000368:Aged; D004279:DNA, Viral / Q000032:analysis; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology / Q000821:virology*; D006801:Humans; D007121:Immunocompetence; D016867:Immunocompromised Host; D008297:Male; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000378:metabolism / Q000821:virology*; D016133:Polymerase Chain Reaction; D011446:Prospective Studies; D018139:Simplexvirus / Q000302:isolation & purification*; D012852:Sinusitis / Q000150:complications / Q000276:immunology / Q000821:virology*
chemical_list: D004279:DNA, Viral