[Preliminary study on the relationship between human histocompatibility leukocyte antigen-G mRNA and recurrent spontaneous abortion].
OBJECTIVE
To examine the expression of Human Histocompatibility Leukocyte Antigen-G (HLA-G) mRNA in placenta from cases of recurrent spontaneous abortion (RSA) and try to study the relationship between HLA-G mRNA and RSA.


METHODS
In situ hybridization was performed on maternal-fetal interface sections of placenta in first trimester, third trimester of normal pregnancy and RSA women who were treated with immunotherapy and had term delivery.


RESULTS
The positive signal of HLA-G expression were showed in all placentas of normal pregnant women within villus and cytoplasma of syncytiotrophoblast and cytotrophoblast. However, there is no any HLA-G mRNA signals in placentas of RSA women after immunotherapy.


CONCLUSIONS
HLA-G mRNA is not the main cause of RSA and there is no direct relations to fetal survival.
Zhang
X
X
Shanghai Insititute of Immunology, Shanghai 200025.
Fan
L
L
Xu
L
L
D000026:Abortion, Habitual / Q000209:etiology / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000096:biosynthesis* / Q000235:genetics; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D010920:Placenta / Q000276:immunology; D011247:Pregnancy; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics
D006680:HLA Antigens; D059951:HLA-G Antigens; D015395:Histocompatibility Antigens Class I; D012333:RNA, Messenger