title: Successful treatment of cervical and simultaneous cervico-isthmic pregnancy with methotrexate.
abstract: OBJECTIVE
  To describe the monitoring of a case of cervical and simultaneous cervico-isthmic pregnancy.
  
  
  METHODS
  University of Bari (Italy), Department of Obstetrics and Gynecology.
  
  
  METHODS
  A 30-year-old white woman, nulliparous, at 8 weeks of amenorrhoea.
  
  
  METHODS
  Methotrexate and folinic acid administered systemically.
  
  
  METHODS
  Treatment success was defined as elimination of the cervical and cervico-isthmic pregnancy, with non-invasive treatment and preservation of the uterus and normal ovarian activity restored.
  
  
  RESULTS
  Methotrexate and folinic acid were administered, elimination of a twin pregnancy with declining serum beta-hCG levels and with ultrasound was observed. The patient had only occasional dark vaginal bleeding and temporary movement of the transaminase.
  
  
  CONCLUSIONS
  This case report shows that methotrexate is a valid, conservative and non-invasive treatment for a patient affected by cervical pregnancy who wishes to keep fertility.
authors.affiliation: Department of Obstetrics and Gynecology, University of Bari, Italy.
authors.forename: G A
authors.initials: GA
authors.lastname: Melilli
authors.forename: G
authors.initials: G
authors.lastname: Cormio
authors.forename: G
authors.initials: G
authors.lastname: Putignano
authors.forename: G
authors.initials: G
authors.lastname: Loverro
authors.forename: L
authors.initials: L
authors.lastname: Selvaggi
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000627:therapeutic use*; D000328:Adult; D002584:Cervix Uteri / Q000473:pathology; D018997:Chorionic Gonadotropin, beta Subunit, Human / Q000097:blood; D005260:Female; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008727:Methotrexate / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D018997:Chorionic Gonadotropin, beta Subunit, Human; D002955:Leucovorin; D008727:Methotrexate