title: [Experience in the use of vessel due F (sulodexide) in patients with suppurative-necrotic forms of diabetic foot without critical ischemia].
abstract: OBJECTIVE
  To evaluate effectiveness of sulodexide in patients with pyonecrotic complications of diabetic foot.
  
  
  METHODS
  Sulodexide was given to 15 patients which were examined for blood fibrinogen, foot tissues saturation with oxygen, microbic contamination of the wound tissue. In addition, ultrasound dopplerography of foot arteries, laser doppler flowmetry were performed.
  
  
  RESULTS
  Fibrinogen in peripheral blood fell, arteriovenous shunting diminished, capillary blood flow and oxygen saturation of the tissues improved.
  
  
  CONCLUSIONS
  Even early sulodexide treatment is effective at different stages of the pathological process in diabetic patients with severe pyonecrotic lesion of the lower limbs as it recovers microcirculatory blood flow.
authors.forename: A M
authors.initials: AM
authors.lastname: Svetukhin
authors.forename: A B
authors.initials: AB
authors.lastname: Zemlianoĭ
authors.forename: S A
authors.initials: SA
authors.lastname: Orudzheva
authors.forename: M I
authors.initials: MI
authors.lastname: Titova
authors.forename: V G
authors.initials: VG
authors.lastname: Rudneva
authors.forename: L V
authors.initials: LV
authors.lastname: Elagina
authors.forename: M V
authors.initials: MV
authors.lastname: Pavlova
authors.forename: R P
authors.initials: RP
authors.lastname: Terekhova
authors.forename: E I
authors.initials: EI
authors.lastname: Bozh'eva
authors.forename: L S
authors.initials: LS
authors.lastname: Makhmudova
mesh_terms: D017719:Diabetic Foot / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008833:Microcirculation; D009336:Necrosis; D013492:Suppuration; D013997:Time Factors
chemical_list: D006025:Glycosaminoglycans; D007004:Hypoglycemic Agents; C007858:glucuronyl glucosamine glycan sulfate