[Destruction of NA innervation in the rat hippocampus resists the hypoxia-induced corticosterone secretion].
With microinjection of 6-hydroxydopamine (6-OHDA) into the ventral hippocampus (VHIP) of rats, the effect of 6-OHDA lesion of hippocampal noradrenergic system on the plasma corticosterone (CS) response to acute hypoxia was investigated. It was found that the plasma CS response to inhalation of 10.4% O2 (30 min) was increased markedly; while the plasma CS level and the noradrenaline (NA) contents in hippocampus were decreased (-33.2% and -38.5%, respectively) 2 weeks after microinfusion of 6-OHDA (8 micrograms/2 microliters) into VHIP; however, the CS response to acute hypoxia was unaffected by 6-OHDA lesion of VHIP. The results above suggest that NA in hippocampus may participate in the regulation of the hypoxia-induced increase of plasma CS concentration in rats.
Zhu
X M
XM
Department of Physiology, Nanjing Railway Medical College, Nanjing 210009.
Zhu
Z T
ZT
Wen
C J
CJ
Zhou
Y Q
YQ
D000818:Animals; D003345:Corticosterone / Q000097:blood / Q000378:metabolism*; D006624:Hippocampus / Q000502:physiology*; D000860:Hypoxia / Q000097:blood*; D008297:Male; D008845:Microinjections; D009638:Norepinephrine / Q000378:metabolism*; D016627:Oxidopamine / Q000494:pharmacology*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley
D016627:Oxidopamine; D003345:Corticosterone; D009638:Norepinephrine