title: A pharmacokinetic model for factor VIII dosing during active haemorrhage in patients with haemophilia A.
abstract: A theoretical one-compartment pharmacokinetic model is described, the aim of which is to guide factor VIII replacement therapy in patients with haemophilia A suffering from significant and ongoing haemorrhage. Based on our calculations, plasma factor VIII concentrations can decrease at a rapid rate even with non-severe blood loss.
authors.affiliation: Department of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China hoamh@cuhk.edu.hk.
authors.forename: A M
authors.initials: AM
authors.lastname: Ho
authors.forename: P
authors.initials: P
authors.lastname: Dion
authors.forename: M K
authors.initials: MK
authors.lastname: Karmakar
authors.forename: G
authors.initials: G
authors.lastname: Cheng
authors.forename: J L
authors.initials: JL
authors.lastname: Derrick
authors.forename: D C
authors.initials: DC
authors.lastname: Chung
authors.forename: B A
authors.initials: BA
authors.lastname: Tay
mesh_terms: D005169:Factor VIII / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D006470:Hemorrhage / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
chemical_list: D005169:Factor VIII