The intrarenal endothelin system and hypertension.
The kidney is both a source of endothelin (ET) generation and an important target organ of this peptide. The highest concentrations of ET-1 in the body exist in the renal medulla, where it mediates natriuretic and diuretic effects through the ET(B) receptor subtype. It is proposed that aberrations in the renal ET system may lead to sodium and water retention and subsequently to the development of hypertension.
Abassi
Z A
ZA
Department of Physiology and Biophysics, Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, 31096 Haifa, Israel.
Ellahham
S
S
Winaver
J
J
Hoffman
A
A
D000818:Animals; D004231:Diuresis / Q000502:physiology; D019332:Endothelin-1 / Q000502:physiology; D016232:Endothelins / Q000502:physiology*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D007668:Kidney / Q000503:physiopathology*; D007679:Kidney Medulla / Q000503:physiopathology; D009318:Natriuresis / Q000502:physiology; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin / Q000502:physiology
D019332:Endothelin-1; D016232:Endothelins; D044023:Receptor, Endothelin B; D017466:Receptors, Endothelin