title: Nifuroxazide in acute diarrhoea: OTC preparation.  Irrational.
abstract: (1) Nifuroxazide, an intestinal antibacterial agent, is now available in France, without a prescription, for the treatment of acute diarrhoea in adults.  (2) According to the only available comparative randomised trial, there is no effect on dehydration.  Relative to a placebo, the mean number of stools is reduced by about one per day during the first two days of treatment, with no significant difference thereafter.
mesh_terms: D000208:Acute Disease / Q000628:therapy; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000627:therapeutic use; D000930:Antidiarrheals / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003362:Cost-Benefit Analysis; D003967:Diarrhea / Q000188:drug therapy* / Q000209:etiology; D005602:France; D006801:Humans; D062385:Hydroxybenzoates / Q000009:adverse effects / Q000627:therapeutic use; D009581:Nitrofurans / Q000009:adverse effects / Q000627:therapeutic use; D004366:Nonprescription Drugs / Q000009:adverse effects / Q000627:therapeutic use; D016896:Treatment Outcome
chemical_list: D000890:Anti-Infective Agents; D000930:Antidiarrheals; D062385:Hydroxybenzoates; D009581:Nitrofurans; D004366:Nonprescription Drugs