A pharmacokinetic model for factor VIII dosing during active haemorrhage in patients with haemophilia A.
A theoretical one-compartment pharmacokinetic model is described, the aim of which is to guide factor VIII replacement therapy in patients with haemophilia A suffering from significant and ongoing haemorrhage. Based on our calculations, plasma factor VIII concentrations can decrease at a rapid rate even with non-severe blood loss.
Ho
A M
AM
Department of Anaesthesia and Intensive Care, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China hoamh@cuhk.edu.hk.
Dion
P
P
Karmakar
M K
MK
Cheng
G
G
Derrick
J L
JL
Chung
D C
DC
Tay
B A
BA
D005169:Factor VIII / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D006470:Hemorrhage / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D008954:Models, Biological
D005169:Factor VIII