[HCV proteins suppress translation].
Viruses influence host cell protein synthesis in various ways. There are many reports that viral infections inhibit host cell translation, in a process called 'translational shutoff'. In most cases, viral translational shutoff gives an advantage to virus survival because host cell translation is suppressed and the translational machinery is used to translate viral RNA instead. However, there are few reports on the effects of hepatitis C virus (HCV) infection on protein synthesis, because of the lack of a reproducible tissue culture system for HCV. We found that HCV also have the effect of translational inhibition. This novel function may help HCV survival.
Kato
J
J
Department of Gastroenterology, Faculty of Medicine, University of Tokyo.
Kato
N
N
Shiratori
Y
Y
Omata
M
M
D002455:Cell Division; D016174:Hepacivirus / Q000235:genetics / Q000472:pathogenicity*; D006526:Hepatitis C / Q000378:metabolism* / Q000821:virology; D006801:Humans; D014176:Protein Biosynthesis; D012367:RNA, Viral / Q000378:metabolism; D017361:Viral Nonstructural Proteins / Q000502:physiology*; D014779:Virus Replication
C093542:NS4 protein, hepatitis C virus; D012367:RNA, Viral; D017361:Viral Nonstructural Proteins