Genetics and animal models of hypoparathyroidism.
Hypoparathyroidism is a heterogeneous group of disorders with diverse etiologies. During the past decade, major advances have been made towards unraveling the precise cellular and molecular mechanisms that underlie the pathogenesis of this endocrinopathy. Studies of patients afflicted with the disease and of genetically altered mice with strategically engineered mutations have paved new and exciting avenues of investigation into its causes. While focusing on these discoveries, we review areas of controversy and discuss possible approaches for their resolution.
Garfield
N
N
Division of Endocrinology, Dept of Medicine and Lady Davis Institute for Medical Research, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, H3T 1E2, Montréal, Canada.
Karaplis
A C
AC
D000818:Animals; D001327:Autoimmune Diseases; D004195:Disease Models, Animal; D004351:Drug Resistance; D006801:Humans; D007011:Hypoparathyroidism / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D009154:Mutation; D010280:Parathyroid Glands / Q000002:abnormalities / Q000503:physiopathology / Q000601:surgery; D010281:Parathyroid Hormone / Q000378:metabolism
D010281:Parathyroid Hormone