Basic fibroblast growth factor in nasal polyps immunohistochemical and quantitative findings.
Basic fibroblast growth factor (bFGF) is a mediator with potent mitogenic properties. Increased amounts of this mediator have been demonstrated in damaged lung tissue, and it has been suggested to increase the healing of gastro-duodenal ulcers. In order to quantify the amounts and document the localization of bFGF in nasal polyps, polyp tissue from 12 patients undergoing polypectomy was analyzed by ELISA and immunohistochemistry. Mucosa from the inferior turbinate was analyzed in the same manner for comparison. The amount of bFGF detected in polyp tissue was significantly higher than that in turbinate mucosa. The amount of bFGF was also significantly higher in the group of patients with high degree of inflammation. The immunohistochemical findings demonstrated abundant bFGF activity mainly in the glandular acini, in the epithelium, in infiltrating inflammatory cells and in the vessel walls. We propose that bFGF may contribute in a significant way to the formation of nasal polyps.
Norlander
T
T
Department of Oto-Rhino-Laryngology, Karolinska Hospital, Stockholm, Sweden. iipo@ent.ks.se
Westermark
A
A
van Setten
G
G
Valtonen
H
H
Ishizaki
H
H
Pyykkö
I
I
D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D005346:Fibroblast Growth Factors / Q000032:analysis*; D006801:Humans; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D008875:Middle Aged; D009297:Nasal Mucosa / Q000737:chemistry*; D009298:Nasal Polyps / Q000737:chemistry* / Q000473:pathology
D005346:Fibroblast Growth Factors