[Structure determination of new antifungal antibiotics, polaramycins A and B].
Antifungal antibiotics, polaramycins A and B have been isolated from the culture of Streptomyces hygroscopicus LP-93. Polaramycins A and B are 36-membered polyol macrolide antibiotics containing hemiacetal monoester of malonic acid and guanidyl groups. Based on spectral evidence including UV, IR, FABMS, 1HNMR, 13CNMR, DEPT, 1H-1H COSY, HETCOR, HMBC, the structure of polaramycins A and B have been assigned as shown in Fig 1 (A, R = H; B, R = CH3).
Meng
W
W
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050.
Jin
W Z
WZ
D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D018942:Macrolides; D015394:Molecular Structure
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; C438030:polaramycin A; C438031:polaramycin B