[Effect of estrogen therapy on the growth of Turner syndrome in girls treated with growth hormone].
Two groups of patients with Turner Syndrome (TS) were studied to analyse the effect of estrogens on their growth. Group 1 (G1): 14 patients treated with growth hormone (GH) who started estrogens (SO) (Premarín) at 15.3 +/- 0.9 years old. Group 2 (G2): 10 girls not treated with GH who started Premarín at 14.3 +/- 2.3 years old. Height SDS improvement in periods of time of GH and GH plus estrogen treatment was evaluated and compared between both groups. The gain in stature during estrogen therapy (final height-projected height at SO) was calculated. In G1 multiple regression was used to examine factors influencing the gain in stature during GH treatment (final height-projected height at the start of GH): bone age at the SO, chronological age at the SO and the time of GH treatment prior to SO. In G1 the height SDS improvement was 0.43 +/- 0.11 cm during GH treatment and 0.59 +/- 0.18 cm during GH plus oestrogens (p = 0.064). The height SDS improvement during estrogen therapy in G2 was 0.14 +/- 0.19 cm, smaller than in G1 (p < 0.001). Gain in stature during estrogen therapy was 5.3 +/- 1.8 cm in G1 and -0.6 +/- 4.2 cm in G2 (p = 0.001). In G1 the time of GH treatment prior to SO was the strongest predictor of the gain in stature during GH treatment (r = 0.89).
Morin
A
A
Sala de Endocrinología y Crecimiento, Hospital SSM Ludovica, La Plata, Argentina. analiamorin@elsitio.net
Guimarey
L
L
Apezteguia
M
M
Santucci
Z
Z
D000293:Adolescent; D001827:Body Height / Q000187:drug effects*; D016022:Case-Control Studies; D004966:Estrogens, Conjugated (USP) / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006128:Growth / Q000187:drug effects*; D019382:Human Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D012044:Regression Analysis; D014424:Turner Syndrome / Q000188:drug therapy*
D004966:Estrogens, Conjugated (USP); D019382:Human Growth Hormone