title: Multidrug-resistant strains of Neisseria gonorrhoeae in Greece.
abstract: Eighty-seven out of 575 gonococci isolated in Greece from 1991 to 1998 belonged to serovar Bropyst and exhibited resistance to penicillin, tetracycline, erythromycin, and chloramphenicol. Conventional and molecular typing showed three clusters, A, B, and C, that were associated with networks of high- frequency transmitters (cluster A with homosexuals and clusters B and C with refugees from Eastern Europe). Study of one isolate revealed mutations in the penA, mtrR, and porB genes that may explain the multidrug-resistant phenotype.
authors.affiliation: National Reference Center for Neisseria gonorrhoeae, Department of Bacteriology, Hellenic Pasteur Institute, Athens, Greece.
authors.forename: A
authors.initials: A
authors.lastname: Mavroidi
authors.forename: L S
authors.initials: LS
authors.lastname: Tzouvelekis
authors.forename: K P
authors.initials: KP
authors.lastname: Kyriakis
authors.forename: H
authors.initials: H
authors.lastname: Avgerinou
authors.forename: M
authors.initials: M
authors.lastname: Daniilidou
authors.forename: E
authors.initials: E
authors.lastname: Tzelepi
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics; D001426:Bacterial Proteins; D002702:Chloramphenicol Resistance / Q000235:genetics / Q000502:physiology; D004352:Drug Resistance, Microbial / Q000235:genetics / Q000502:physiology*; D018432:Drug Resistance, Multiple / Q000235:genetics / Q000502:physiology*; D004917:Erythromycin / Q000494:pharmacology; D005287:Ferredoxin-NADP Reductase; D006115:Greece; D006801:Humans; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000235:genetics / Q000502:physiology*; D010403:Penicillin Resistance / Q000235:genetics / Q000502:physiology; D018272:Porins; D012097:Repressor Proteins / Q000235:genetics; D013753:Tetracycline Resistance / Q000235:genetics / Q000502:physiology
chemical_list: D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D018272:Porins; D012097:Repressor Proteins; C057699:porin protein, Neisseria; C087450:mtrR protein, Neisseria gonorrhoeae; D004917:Erythromycin; C111241:methionine synthase reductase; D005287:Ferredoxin-NADP Reductase