Pregnancy following transfer of cryopreserved-thawed embryos that had been a result of fertilization of all in vitro matured metaphase or germinal stage oocytes. case report.
OBJECTIVE
To see if pregnancies can be achieved after performing intracytoplasmic sperm injection (ICSI) of in vitro matured metaphase I or germinal vesicle stage oocytes and then cryopreserving them at the 2 pronuclear stage.


METHODS
Transfer of frozen/thawed hatched day 3 embryos to two women. All embryos were a result of in vitro maturation of immature oocytes followed by ICSI.


RESULTS
Both women conceived. One has delivered and one has successfully completed the first trimester.


CONCLUSIONS
These two cases represent only the second and third reported cases of pregnancies following frozen embryo transfer where the embryos resulted from fertilizing immature oocytes by ICSI.
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M L
ML
The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Copper Hospital/University Medical Center, Department of Obstetrics and Gynecology, USA.
Brittingham
D
D
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J H
JH
Choe
J K
JK
D000328:Adult; D015925:Cryopreservation; D004624:Embryo Transfer; D005260:Female; D006801:Humans; D008297:Male; D009865:Oocytes / Q000254:growth & development*; D011247:Pregnancy; D011256:Pregnancy Outcome; D020554:Sperm Injections, Intracytoplasmic