[Humoral effectors and cellular targets of chronic arterial wall allorejection].
Contrasting with acute rejection, chronic rejection of arterial allograft don't involve leukocyte passengers from the graft to the host. Chronic rejection involves the proteins of the major histocompatibility complexes. Experimental studies in rats showed that the process evolved in three stages: a first stage of histo-incompatibility recognition mediated by the graft endothelium, a second stage of immune antibody-dependent injury of allogenic smooth muscle cells of the media associated with inflammatory infiltration of the adventitia, lastly a third stage of scarring process including intimal proliferation and adventitial fibrosis.
Michel
J B
JB
Unité 460 de 1'INSERM, CHU X. Bichat, 16 rue Henri Huchard-75018 Paris.
Plissonnier
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Gomes
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D000818:Animals; D000917:Antibody Formation / Q000276:immunology*; D001011:Aorta / Q000276:immunology* / Q000637:transplantation*; D002908:Chronic Disease; D004195:Disease Models, Animal; D004730:Endothelium, Vascular / Q000276:immunology*; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D007249:Inflammation; D008285:Major Histocompatibility Complex / Q000276:immunology*; D009131:Muscle, Smooth, Vascular / Q000276:immunology*; D051381:Rats