title: [Detection of antineutrophil cytoplasmic autoantibodies in pregnancy induced hypertension and its clinical significance].
abstract: OBJECTIVE
  To explore the level of antineutrophil cytoplasmic autoantibodies (ANCA) in patients with pregnancy induced hypertension (PIH) and its clinical significance.
  
  
  METHODS
  37 cases with PIH and 39 non-PIH pregnancy were studied for ANCA by indirect immunflourscence.
  
  
  RESULTS
  ANCA positive rates were 33.3%, 88.9% and 86.4% in mild, moderate, severe PIH, respectively, and most of them were c-ANCA. The positive rate was only 13.2% in non-PIH control, significantly lower than those in PIH (P < 0.001).
  
  
  CONCLUSIONS
  ANCA may be one of the causes for endothelial cell damage and a predicting marker in PIH.
authors.affiliation: Research and Training Center in Women's and Children's Health, First Affiliated Hospital, Beijing Medical University, Beijing 100034.
authors.forename: W
authors.initials: W
authors.lastname: Zhao
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy
chemical_list: D019268:Antibodies, Antineutrophil Cytoplasmic