Feline immunodeficiency virus model to study human immunodeficiency virus/acquired immune deficiency syndrome conditions.
This study was designed to induce rapid progression of the feline immunodeficiency virus (FIV) infection in cats. Predictably inducing the FIV disease state in the cat would yield an excellent tool to study endodontic disease processes under immunosuppressed conditions. Eight cats were immunosuppressed with steroids before infection with FIV. Another eight cats, age- and sex-matched littermates, served as uninoculated seronegative controls. Complete blood counts were taken for 10 mo in the FIV group, and 10 wk in the control group, including lymphocyte subsets. ELISAs were used to detect FIV infection. Statistical analysis was performed with generalized estimating equation models. All cats were positive at one point in time. The FIV group had significantly lower peripheral blood CD4+ counts compared with the control group. Therefore the FIV model presented gives the desired outcome and simulates what occurs in human immunodeficiency virus infection.
Levine
D F
DF
Baylor College of Dentistry, Texas A&M University System Health Science Center, Dallas 75246, USA.
Gutmann
J L
JL
Witherspoon
D E
DE
Nunn
M E
ME
Wiggs
R B
RB
D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology*; D000818:Animals; D018791:CD4 Lymphocyte Count; D016516:CD4-CD8 Ratio; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D016022:Case-Control Studies; D002415:Cats; D003788:Dental Pulp Diseases / Q000503:physiopathology; D004195:Disease Models, Animal; D018450:Disease Progression; D004797:Enzyme-Linked Immunosorbent Assay; D004906:Erythrocyte Count; D005240:Feasibility Studies; D016181:Feline Acquired Immunodeficiency Syndrome / Q000503:physiopathology*; D005500:Follow-Up Studies; D015658:HIV Infections / Q000503:physiopathology*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D016867:Immunocompromised Host; D016089:Immunodeficiency Virus, Feline; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D007958:Leukocyte Count; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets / Q000473:pathology; D008297:Male; D012044:Regression Analysis
D006454:Hemoglobins; D007166:Immunosuppressive Agents