[Efficacy of a triclosan/copolymer dentifrice in the control of plaque and gingivitis: a six-month study in China].
A total of one hundred fifty three healthy male and female adults were entered into a six month, double-blind clinical study designed to evaluate the effect of a dentifrice containing 0.3% triclosan and 2.0% PVM/MA copolymer in a 0.243% sodium fluoride/silica base, relative to a 0.243% sodium fluoride silica base control dentifrice on supragingival plaque accumulation and gingivitis. Plaque and gingivitis were scored after 3 and 6 months' use of the assigned dentifrice. At the end of the study, the dentifrice containing triclosan/copolymer demonstrated an average reduction, relative to the control dentifrice of 16.1% in plaque accumulation and 24.3% in gingivitis. Both were statistically significant(P < 0.001). It was concluded that the twice-daily use of the triclosan/copolymer containing dentifrice resulted in a significant reduction in plaque formation and a significant improvement in gingival health. No side-effects were observed.
Hu
D
D
College of Stomatology, West China University of Medical Sciences, China.
Zhang
J
J
Wan
H
H
Zhang
Y
Y
Volpe
A R
AR
Petrone
M E
ME
D000328:Adult; D000891:Anti-Infective Agents, Local / Q000627:therapeutic use*; D003773:Dental Plaque / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008298:Maleates / Q000627:therapeutic use; D008875:Middle Aged; D011095:Polyethylenes / Q000627:therapeutic use; D014100:Toothpastes / Q000627:therapeutic use; D014260:Triclosan / Q000627:therapeutic use*
D000891:Anti-Infective Agents, Local; D008298:Maleates; D011095:Polyethylenes; D014100:Toothpastes; D014260:Triclosan; C043105:poly(methyl vinyl ether-co-maleic anhydride)