Regulation of Na+ channel distribution in the nervous system.
An important aspect of Na+ channel regulation is their distribution on neuronal membranes within the nervous system. The complexity of this process is brought by the molecular diversity of Na+ channels and differential regulation of their distribution. In addition, Na+ channel localization is a highly dynamic process depending on the status of the cell in vitro, and (patho)physiological condition of the organism in vivo. Nonetheless, the pharmacological manipulation of Na+ channel distribution should be possible and will hopefully bring safer and more-potent medicines in the future.
Novakovic
S D
SD
Roche Bioscience, Palo Alto, CA 94304-1397, USA. sanja.novakovic@roche.com
Eglen
R M
RM
Hunter
J C
JC
D000818:Animals; D001923:Brain Chemistry / Q000502:physiology*; D009420:Nervous System / Q000378:metabolism*; D015222:Sodium Channels / Q000032:analysis* / Q000378:metabolism*
D015222:Sodium Channels