title: Short-duration oral terbinafine for the treatment of tinea pedis in HIV-positive patients.
abstract: Management of tinea pedis in patients who have the human immunodeficiency virus (HIV) is problematic; in those patients, dermatophytoses may be more difficult to treat than in the general population. This prospective, open-label, multicenter, randomized study evaluated the efficacy and safety of a short course of oral terbinafine for tinea pedis in patients who are HIV positive. Twenty-seven patients were randomized to receive oral terbinafine 250 mg once daily for 2 or 4 weeks; 17 patients with positive initial cultures and follow-up cultures were evaluable for efficacy at week 8. Mycological cure (defined as negative potassium hydroxide [KOH] microscopy and culture results) occurred in 47% (8) of patients; and modified mycological cure (defined as negative follow-up cultures) occurred in 65% (11) of patients. All 27 patients were evaluated for safety. Clinical cure (defined as minimal residual signs and symptoms) occurred in 82% (14) of patients. Oral terbinafine was well tolerated, indicating that regimens of 2 or 4 weeks are safe and effective for the treatment of tinea pedis in patients who are HIV positive.
authors.affiliation: Department of Dermatology, University of California, San Diego, USA.
authors.forename: S
authors.initials: S
authors.lastname: Smith
authors.forename: K
authors.initials: K
authors.lastname: Houpt
authors.forename: P
authors.initials: P
authors.lastname: Rich
authors.forename: A
authors.initials: A
authors.lastname: LaMarca
authors.forename: J M
authors.initials: JM
authors.lastname: Weinberg
authors.forename: T S
authors.initials: TS
authors.lastname: Alferez
authors.forename: E
authors.initials: E
authors.lastname: Atillasoy
authors.forename: C
authors.initials: C
authors.lastname: Opper
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D015658:HIV Infections / Q000150:complications / Q000276:immunology; D006801:Humans; D016867:Immunocompromised Host / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000008:administration & dosage / Q000627:therapeutic use*; D000077291:Terbinafine; D013997:Time Factors; D014008:Tinea Pedis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D009281:Naphthalenes; D000077291:Terbinafine