Microporous material from kanemite for drug inclusion and release.
A microporous material obtained from kanemite, a layered polysilicate, was studied in order to investigate its feasibility of including drugs and then releasing them. Diphenydramine hydrochloride was chosen as a model drug. The preparation of the microporous material and its loading with the drug are described. As kanemite is able to intercalate anions between its layers, the intercalation compound of diphenydramine and kanemite was also prepared. Both the drug-loaded microporous material and the intercalation compound were submitted to dissolution tests at pH 7.5. The drug release profiles from these two different materials and from a physical mixture were compared.
Ambrogi
V
V
Dipartimento di Chimica e Tecnologia del Farmaco, Università degli Studi di Perugia, Italy.
Chiappini
I
I
Fardella
G
G
Grandolini
G
G
Marmottini
F
F
Perioli
L
L
D004155:Diphenhydramine / Q000737:chemistry; D005079:Excipients; D007364:Intercalating Agents / Q000737:chemistry; D016062:Porosity; D017640:Silicates / Q000737:chemistry*; D012995:Solubility; D012997:Solvents; D014961:X-Ray Diffraction
D005079:Excipients; D007364:Intercalating Agents; D017640:Silicates; D012997:Solvents; D004155:Diphenhydramine