title: The role of ITAM- and ITIM-coupled receptors in platelet activation by collagen.
abstract: The major activation-inducing collagen receptor glycoprotein VI (GPVI) has been cloned within the last two years. It is a member of the Ig superfamily of proteins and is constitutively associated with the ITAM-bearing Fc receptor gamma-chain (FcR gamma-chain). GPVI signals through a pathway that involves several of the proteins used by Fc, B- and T-lymphocyte receptors and which takes place in glycolipid-enriched membrane domains in the plasma membrane known as GEMs. Responses to GPVI are regulated by PECAM-1 (CD31) and possibly other ITIM-bearing receptors. Despite a pivotal role for GPVI, there are important differences between signalling events to collagen and GPVI-specific ligands. This may reflect a role for co-receptors in the response to collagen.
authors.affiliation: Department of Pharmacology, University of Oxford, UK. steve.watson@pharm.ox.ac.uk
authors.forename: S P
authors.initials: SP
authors.lastname: Watson
authors.forename: N
authors.initials: N
authors.lastname: Asazuma
authors.forename: B
authors.initials: B
authors.lastname: Atkinson
authors.forename: O
authors.initials: O
authors.lastname: Berlanga
authors.forename: D
authors.initials: D
authors.lastname: Best
authors.forename: R
authors.initials: R
authors.lastname: Bobe
authors.forename: G
authors.initials: G
authors.lastname: Jarvis
authors.forename: S
authors.initials: S
authors.lastname: Marshall
authors.forename: D
authors.initials: D
authors.lastname: Snell
authors.forename: M
authors.initials: M
authors.lastname: Stafford
authors.forename: D
authors.initials: D
authors.lastname: Tulasne
authors.forename: J
authors.initials: J
authors.lastname: Wilde
authors.forename: P
authors.initials: P
authors.lastname: Wonerow
authors.forename: J
authors.initials: J
authors.lastname: Frampton
mesh_terms: D020816:Amino Acid Motifs; D000818:Animals; D003094:Collagen / Q000494:pharmacology*; D006801:Humans; D015539:Platelet Activation / Q000187:drug effects*; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism / Q000502:physiology; D017434:Protein Structure, Tertiary; D011971:Receptors, Immunologic / Q000502:physiology*; D015398:Signal Transduction; D014443:Tyrosine
chemical_list: D010980:Platelet Membrane Glycoproteins; D011971:Receptors, Immunologic; C098341:platelet membrane glycoprotein VI; D014443:Tyrosine; D003094:Collagen