title: Anticaries profile qualification of an improved whitening dentifrice.
abstract: A series of pH cycling "profile" laboratory studies was conducted to confirm the anticaries potential of an enhanced cleaning and whitening dentifrice based on a novel abrasive polishing silica and pyrophosphate tartar control source, with sodium fluoride as the anticaries ingredient. Under pH cycling remineralization conditions, the whitening dentifrice produced lesion fluoridation comparable to a conventional tartar control dentifrice containing combinations of pyrophosphate anion and a NaF fluoride ion source. Under pH cycling lesion progression conditions, the whitening dentifrice produced enamel protection against caries development, comparable to control dentifrices containing NaF alone or in combination with tartar control pyrophosphate anion. These results are consistent with clinical data supporting the effectiveness of NaF dentifrices combined with anionic tartar control inhibitors such as pyrophosphate. These results support the anticaries effectiveness of the enhanced cleaning and whitening dentifrice based upon "Stain-Specific Soft Silica."
authors.affiliation: Procter & Gamble Company, Health Care Research Center, Mason, OH, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Pfarrer
authors.forename: D J
authors.initials: DJ
authors.lastname: White
authors.forename: J D
authors.initials: JD
authors.lastname: Featherstone
mesh_terms: D000704:Analysis of Variance; D002327:Cariostatic Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003728:Dental Calculus / Q000517:prevention & control; D003731:Dental Caries / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D003743:Dental Enamel / Q000187:drug effects; D003802:Dentifrices / Q000737:chemistry / Q000627:therapeutic use*; D011756:Diphosphates / Q000737:chemistry / Q000627:therapeutic use; D018450:Disease Progression; D006244:Hardness; D006801:Humans; D006863:Hydrogen-Ion Concentration; D012822:Silicon Dioxide / Q000737:chemistry / Q000627:therapeutic use; D012969:Sodium Fluoride / Q000493:pharmacokinetics / Q000627:therapeutic use; D014073:Tooth Bleaching; D017001:Tooth Demineralization / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control; D014075:Tooth Discoloration / Q000628:therapy*; D014089:Tooth Remineralization
chemical_list: D002327:Cariostatic Agents; D003802:Dentifrices; D011756:Diphosphates; D012822:Silicon Dioxide; D012969:Sodium Fluoride