Cytokeratin-positive, CD45-negative primary centroblastic lymphoma of the adrenal gland: a potential for a diagnostic pitfall.
We report a case of cytokeratin-positive, CD45-negative primary polymorphic centroblastic lymphoma of the adrenal gland. Additional immunostaining, which demonstrated positivity for CD20 and kappa light chain, as well as detection of the monoclonal rearrangement of the immunoglobulin heavy chain gene, helped to establish the diagnosis of lymphoma and to rule out an initially favored diagnosis of poorly differentiated carcinoma.
Donner
L R
LR
Department of Pathology, Division of Hematology/Oncology, Scott & White Memorial Hospital and Clinic, Texas A & M University College of Medicine, 2401 S 31st St, Temple, TX 76508, USA. ldonner@sw.org
Mott
F E
FE
Tafur
I
I
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000473:pathology; D000368:Aged; D018951:Antigens, CD20 / Q000032:analysis; D002466:Cell Nucleolus / Q000473:pathology; D002467:Cell Nucleus / Q000473:pathology; D002843:Chromatin / Q000473:pathology; D003593:Cytoplasm / Q000473:pathology; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis*; D017493:Leukocyte Common Antigens / Q000032:analysis*; D008223:Lymphoma / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D014057:Tomography, X-Ray Computed
D018951:Antigens, CD20; D002843:Chromatin; D007143:Immunoglobulin Heavy Chains; D007145:Immunoglobulin kappa-Chains; D007633:Keratins; D017493:Leukocyte Common Antigens