title: Management of venous thromboembolism in pregnancy.
abstract: Pulmonary thromboembolism (PTE) is the major cause of maternal death in the UK, with recent trends showing an increase in the numbers of deaths. Underlying PTE is the problem of deep venous thrombosis (DVT). An appreciation of risk factors, particularly, thrombophilia, and signs or symptoms suggestive of thromboembolism, coupled with objective diagnosis and treatment should reduce mortality and morbidity. There are particular considerations with regard to the management of thrombosis in pregnancy, especially the use of anticoagulants. Low-molecular-weight heparins are now replacing unfractionated heparin for the treatment of DVT and PTE in pregnancy.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Glasgow, Glasgow, Scotland, UK.
authors.forename: I A
authors.initials: IA
authors.lastname: Greer
authors.forename: A J
authors.initials: AJ
authors.lastname: Thomson
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use; D002585:Cesarean Section / Q000009:adverse effects; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D008423:Maternal Age; D009765:Obesity / Q000150:complications; D011237:Predictive Value of Tests; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D018566:Pregnancy, High-Risk; D011655:Pulmonary Embolism / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D012008:Recurrence; D012307:Risk Factors; D019851:Thrombophilia / Q000150:complications / Q000175:diagnosis; D018616:Ultrasonography, Doppler, Duplex; D014689:Venous Insufficiency / Q000209:etiology; D020246:Venous Thrombosis / Q000175:diagnosis / Q000209:etiology / Q000628:therapy*; D014692:Ventilation-Perfusion Ratio
chemical_list: D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight