Transitional cell carcinoma of the urinary bladder following exposure to cyclophosphamide in childhood.
With the increasing survival of children with malignancies, the long-term effects of chemotherapies are now becoming important and one of these dreadful long-term complications is the development of a second malignancy. Described here is a case of transitional cell carcinoma of the bladder developing 8 years following exposure to cyclophosphamide for the treatment of embryonal rhabdomyosarcoma.
Agarwala
S
S
Department of Paediatric Surgery, All India Institute of Medical Sciences, New Delhi. sandpagr@hotmail.com
Hemal
A K
AK
Seth
A
A
Gupta
A K
AK
Bhatnagar
V
V
Mitra
D K
DK
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols; D001859:Bone Neoplasms / Q000151:congenital / Q000188:drug therapy*; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000627:therapeutic use; D003558:Cystoscopy / Q000379:methods; D003609:Dactinomycin; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D011859:Radiography; D018714:Radiotherapy, Adjuvant; D012208:Rhabdomyosarcoma / Q000151:congenital / Q000188:drug therapy*; D013997:Time Factors; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000628:therapy; D014750:Vincristine
D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide