title: A neuropsychological study of dissociation in cortical and subcortical functioning in obsessive-compulsive disorder by Tower of Hanoi task.
abstract: Several biological models of Obsessive-Compulsive Disorder (OCD) have focused on the roles frontal cortex and basal ganglia dysfunctions play in the expression of the disorder. From a neuropsychological point of view, previous reports have underlined the possible involvement of the prefrontal cortex in declarative functions and the basal ganglia in procedural ones. A possible dissociation of cortical and subcortical functioning has been studied using the Hanoi Tower Task to explore different neuropsychological aspects of problem-solving procedures. Our results indicate that differential cortical and subcortical dysfunctions could contribute to OCD pathophysiology and that procedural and declarative forms might be independent of each other.
authors.affiliation: Department of Neuropsychiatric Sciences 20, San Raffaele University, Via Stamira d'Ancona, 20127 Milan, Italy. paolo.cavedini@hsr.it
authors.forename: P
authors.initials: P
authors.lastname: Cavedini
authors.forename: M
authors.initials: M
authors.lastname: Cisima
authors.forename: G
authors.initials: G
authors.lastname: Riboldi
authors.forename: A
authors.initials: A
authors.lastname: D'Annucci
authors.forename: L
authors.initials: L
authors.lastname: Bellodi
mesh_terms: D000328:Adult; D001921:Brain / Q000503:physiopathology*; D003072:Cognition Disorders / Q000209:etiology* / Q000503:physiopathology*; D005260:Female; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009771:Obsessive-Compulsive Disorder / Q000150:complications* / Q000503:physiopathology*; D011340:Problem Solving