[Endothelin-1 in pathogenesis of Raynaud's syndrome].
Endothelin is an endogenous vasoconstrictor and plays an important role in pathogenesis of Raynaud's phenomenon. Plasma endothelin-1 (ET-1) and von Willebrand factor (vWF) concentrations following cold exposure in 52 patients with Raynaud's phenomenon were measured. Statistically significant increase of ET-1 and vWF was found in the study group in compare to healthy volunteers. There was positive correlation between ET-1 and vWF in those cases. The dates suggest that ET-changes indicates a vasospastic effect on vascular injury. Treatment with endothelin-receptor antagonist may prevent structural changes in vessel well.
Knapik-Kordecka
M
M
Katedra i Klinika Angiologii Akademii Medycznej we Wrocławiu.
Adamiec
R
R
Ciosek
W
W
D000328:Adult; D000368:Aged; D019332:Endothelin-1 / Q000097:blood*; D004730:Endothelium, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011928:Raynaud Disease / Q000097:blood* / Q000503:physiopathology*; D014841:von Willebrand Factor / Q000032:analysis
D019332:Endothelin-1; D014841:von Willebrand Factor