Methyl parathion induced alterations in monoaminergic system of developing rat pups.
Methyl parathion induced alterations in the level of monoamines, viz. norepinephrine, dopamine and serotonin were studied in discrete regions of developing central nervous system of rat pups. A significant decrease in the level of monoamines noticed in methyl parathion toxicosis may be related to the altered neuronal activity and inefficiency, leading to depression and impairment in various behavioural activities. In contrast to AChE inhibition, monoamine oxidase (MAO) activity showed an increasing trend and it could cause deamination of catecholamines and accumulation of its metabolites. This suggests that an increased AChE inhibition may indirectly stimulate MAO activity in developing rat pups exposed to methyl parathion.
Mahaboob Basha
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Department of Zoology, Bangalore University, India.
Begum
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S
Nayeemunnisa
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D002490:Central Nervous System / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000633:toxicity; D007306:Insecticides / Q000633:toxicity; D008743:Methyl Parathion / Q000633:toxicity*; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats
D015306:Biogenic Monoamines; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D008743:Methyl Parathion; D008995:Monoamine Oxidase; D000109:Acetylcholine