Molecular evolution of Aldolase A pseudogenes in mice: multiple origins, subsequent duplications, and heterogeneity of evolutionary rates.
The Aldolase multigene family comprises three functional genes (A, B, and C) with tissue-specific expression regulated during ontogeny. DGGE analysis and nucleotide sequencing reveal a family of retropseudogenes of type A in species of MUS: Significant variation in rates of evolution of Aldolase A retropseudogenes is apparent. Our analyses demonstrate that (1) multiple events of retrotransposition are needed to account for the diversity of Aldolase A processed pseudogenes found in mice; (2) some of these sequences have undergone further duplication subsequent to the original retrotransposition event; (3) the patterns of nucleotide substitution are broadly comparable with previous estimates; and (4) estimates of rates of divergence for this array of sequences are up to four times higher than those reported in the literature.
Cortinas
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MN
Laboratorio de Evolución, Facultad de Ciencias, Montevideo, Uruguay. manoel@fcien.edu.uy
Lessa
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EP
D000818:Animals; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004586:Electrophoresis / Q000379:methods; D019143:Evolution, Molecular; D005634:Fructose-Bisphosphate Aldolase / Q000235:genetics*; D020440:Gene Duplication; D014644:Genetic Variation; D051379:Mice; D008809:Mice, Inbred C3H; D008969:Molecular Sequence Data; D010802:Phylogeny; D011544:Pseudogenes / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013997:Time Factors
D004247:DNA; D005634:Fructose-Bisphosphate Aldolase