The structure of physalin T from Physalis alkekengi var. franchetti.
A new steroidal constituent named physalin T (3) was isolated from the aqueous extract of Physalis alkekengi var. francheti. Based on 1H and 13C NMR spectral studies the structure was assigned as 2,3-dihydrophysalin D, i.e., 5alpha,6beta-dihydroxy-2,3,5,6-tetrahydrophysalin B, which is the first example of a natural physalin possessing a saturated ring A moiety. The structure was confirmed by the chemical transformation from the known physalin D (2) to physalin T.
Kawai
M
M
Department of Applied Chemistry, Nagoya Institute of Technology, Japan. kawai@ach.nitech.ac.jp
Yamamoto
T
T
Makino
B
B
Yamamura
H
H
Araki
S
S
Butsugan
Y
Y
Saito
K
K
D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D007564:Japan; D019906:Nuclear Magnetic Resonance, Biomolecular; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D012632:Secosteroids; D019657:Solanaceae / Q000737:chemistry*; D013055:Spectrophotometry, Infrared; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification*; D013329:Structure-Activity Relationship
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D012632:Secosteroids; D013256:Steroids; C441429:physalin D; C441428:physalin T