title: The structure of McN-5652.
abstract: The configuration of the diastereoisomers of 6-(4-methylthiophenyl)-1,2,3,5,6,10b-hexahydropyrrolo[2,1-a]isoquinoline 1 (McN-5652) is determined and unequivocally assigned by NMR spectroscopy (NOE measurements) and an X-ray structural analysis of the trans diastereoisomer. The enantiomers of cis-1 are separated by preparative HPLC on a chiral phase. One of the enantiomers of cis-1 represents the precursor for imaging the serotonin 5-HT transporter with positron emission tomography (PET).
authors.affiliation: Institut für Organische Chemie der Universität Hamburg, Martin-Luther-King-Platz 6, 20146, Hamburg, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Schulze
authors.forename: U
authors.initials: U
authors.lastname: Schmidt
authors.forename: J
authors.initials: J
authors.lastname: Voss
authors.forename: B
authors.initials: B
authors.lastname: Nebeling
authors.forename: G
authors.initials: G
authors.lastname: Adiwidjaja
authors.forename: K
authors.initials: K
authors.lastname: Scharwächter
mesh_terms: D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D007546:Isoquinolines / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D012702:Serotonin Antagonists / Q000737:chemistry*
chemical_list: D007546:Isoquinolines; D012702:Serotonin Antagonists; C058079:McN 5652