Montelukast in 2- to 5-year-old children with asthma.
Pediatric dose selection for montelukast in 2-5-year-old children was based on a pharmacokinetic approach that was also used in previously selecting a once-daily 5-mg chewable tablet for asthmatic children 6-14 years of age. A 4-mg chewable tablet administered once daily was determined to be the correct dose and was subsequently found to be safe and effective in asthmatic children 2-5 years of age.
Skoner
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Department of Allergy and Immunology, Children's Hospital of Pittsburgh, 3705 Fifth Ave., 4B 320, Pittsburgh, PA 15213, USA. skonerd@chplink.chp.edu
D000085:Acetates / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000284:Administration, Oral; D001249:Asthma / Q000188:drug therapy*; D002675:Child, Preschool; D003521:Cyclopropanes; D005260:Female; D006801:Humans; D020024:Leukotriene Antagonists / Q000008:administration & dosage* / Q000493:pharmacokinetics; D008297:Male; D011804:Quinolines / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013440:Sulfides
D000085:Acetates; D003521:Cyclopropanes; D020024:Leukotriene Antagonists; D011804:Quinolines; D013440:Sulfides; C093875:montelukast