title: ABO/Secretor genetic complex and susceptibility to asthma in childhood.
abstract: A positive association has recently been reported in adult subjects between O/nonSecretor phenotype and asthma. To confirm this association, this study investigated the joint ABO/Secretor phenotype in a cohort of 165 asthmatic children. Three-hundred and sixty-two consecutive newborn infants from the same population were also studied as controls. The proportion of O/nonSecretor in asthmatic children was higher than in controls, thus confirming the association found in adults. The association was more marked in males than in females. In males, the pattern of association between the joint ABO/Secretor phenotype and asthma is dependent on the age at on-set of symptoms. Since the oligosaccharide composition of cell membrane and mucosal secretions is controlled by the cooperative interaction of ABO and Secretor genes, and since such composition influences the adhesion of infectious agents, the age pattern could reflect a more general interaction between developmental maturation and oligosaccharide structure concerning their effects on susceptibility to viral and bacterial agents.
authors.affiliation: Institute of Pediatric Clinic, University of Rome La Sapienza, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Ronchetti
authors.forename: M P
authors.initials: MP
authors.lastname: Villa
authors.forename: R
authors.initials: R
authors.lastname: Ronchetti
authors.forename: E
authors.initials: E
authors.lastname: Bonci
authors.forename: L
authors.initials: L
authors.lastname: Latini
authors.forename: R
authors.initials: R
authors.lastname: Pascone
authors.forename: N
authors.initials: N
authors.lastname: Bottini
authors.forename: F
authors.initials: F
authors.lastname: Gloria-Bottini
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000293:Adolescent; D001249:Asthma / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005647:Fucosyltransferases / Q000235:genetics*; D020022:Genetic Predisposition to Disease / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D010641:Phenotype; D012384:Rome; D000097631:Galactoside 2-alpha-L-fucosyltransferase
chemical_list: D000017:ABO Blood-Group System; D005647:Fucosyltransferases; D000097631:Galactoside 2-alpha-L-fucosyltransferase