title: Cardiac phase contrast gradient echo MRI: characterization of abnormal left ventricular wall motion in patients with ischemic heart disease.
abstract: OBJECTIVE
  In our patient study, we examined the clinical usefulness of phase contrast velocity mapping for the detection and characterization of localized abnormalities of left ventricular motion.
  
  
  METHODS
  Velocity encoding is based on the fact that motion in the presence of a magnetic field gradient causes a change of the phase of the MRI signal that is proportional to the velocity of tissue motion. Left ventricular motion was characterized by parameters describing rotation and contraction/dilatation, respectively. We examined 34 patients with localized abnormalities of left ventricular motion due to ischemic heart disease.
  
  
  RESULTS
  Three patients could not be sufficiently evaluated due to technical problems including varying positions of the heart during successive breathhold periods. In 27 of the remaining 31 patients, MRI could demonstrate abnormal radial velocities that corresponded fully or partly with perfusion deficits in single photon emission computed tomography or positron emission tomography. The abnormalities were most pronounced in early diastole. Rotational velocities did not show any regional changes.
  
  
  CONCLUSIONS
  Our study showed that our technique is suitable for the detection and characterization of localized abnormalities of left ventricular motion in patients with ischemic heart disease.
authors.affiliation: Department of Diagnostic Radiology, Freiburg University Medical Center, Freiburg, Germany. schneider@mrs1.ukl.uni-freiburg.de
authors.forename: B
authors.initials: B
authors.lastname: Schneider
authors.forename: M
authors.initials: M
authors.lastname: Markl
authors.forename: C
authors.initials: C
authors.lastname: Geiges
authors.forename: J T
authors.initials: JT
authors.lastname: Winterer
authors.forename: C
authors.initials: C
authors.lastname: Thuerl
authors.forename: J
authors.initials: J
authors.lastname: Laubenberger
authors.forename: J
authors.initials: J
authors.lastname: Hennig
authors.forename: M
authors.initials: M
authors.lastname: Langer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications / Q000473:pathology*; D012680:Sensitivity and Specificity; D015899:Tomography, Emission-Computed, Single-Photon; D018487:Ventricular Dysfunction, Left / Q000473:pathology*