Effect of Carmeda BioActive Surface coating versus Trillium Biopassive Surface coating of the oxygenator on circulating platelet count drop during cardiopulmonary bypass.
An investigation was conducted to evaluate the effect that surface coating of the hollow-fiber membrane oxygenator had on circulating platelet count drop during cardiopulmonary bypass (CPB). Sixty patients undergoing non-emergency myocardial revascularization for coronary artery disease were randomly divided into two groups. Group one (n = 32) received the Carmeda-coated Maxima-Plus PRF oxygenator while the patients in Group two (n=28) received the Trillium-coated Affinity oxygenator during CPB. The net platelet count drops for the pump specimen (15-20 min after the initiation of bypass) for the Carmeda and the Trillium groups were 3.6 +/- 15.8% and 6.2 +/- 10.2%, respectively. The net platelet count drop for the warming specimen for the Carmeda and the Trillium groups were 2.9 +/- 19.4% and 0.5 +/- 11.0%, respectively. There were no statistically significant differences between the groups. The authors conclude that using either the Carmeda-coated Maxima-Plus PRF oxygenator or the Trillium-coated Affinity oxygenator afford similar benefits in regards to preserving circulating platelet counts during bypass.
Palanzo
D A
DA
Department of Perfusion, Lehigh Valley Hospital, Allentown, Pennsylvania 18105, USA. dpalanzo@enter.net
Zarro
D L
DL
Manley
N J
NJ
Montesano
R M
RM
Quinn
M
M
Elmore
B A
BA
Gustafson
P A
PA
Castagna
J M
JM
D000368:Aged; D002315:Cardiopulmonary Bypass / Q000295:instrumentation*; D020099:Coated Materials, Biocompatible / Q000494:pharmacology* / Q000592:standards; D005260:Female; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010107:Oxygenators, Membrane; D010976:Platelet Count; D011108:Polymers / Q000494:pharmacology; D013499:Surface Properties
D020099:Coated Materials, Biocompatible; D011108:Polymers; D006493:Heparin