title: Trypanosome lytic factors: novel mediators of human innate immunity.
abstract: A novel trypanosome lytic factor (TLF) has been characterized that protects humans from infection by Trypanosoma brucei brucei. The mechanism of trypanolysis is unknown; contrary to one hypothesis, TLF does not kill trypanosomes by generating oxygen radicals. However, these trypanosomes become human-infective when they express a serum-resistance-associated gene.
authors.affiliation: Department of Medical and Molecular Parasitology, New York University School of Medicine, 341 East 25th Street, New York, NY 10010, USA. Jayne.Raper@med.nyu.edu
authors.forename: J
authors.initials: J
authors.lastname: Raper
authors.forename: M P
authors.initials: MP
authors.lastname: Portela
authors.forename: E
authors.initials: E
authors.lastname: Lugli
authors.forename: U
authors.initials: U
authors.lastname: Frevert
authors.forename: S
authors.initials: S
authors.lastname: Tomlinson
mesh_terms: D000818:Animals; D006801:Humans; D007113:Immunity, Innate; D008075:Lipoproteins, HDL / Q000276:immunology*; D014346:Trypanosoma brucei brucei / Q000276:immunology* / Q000472:pathogenicity; D014353:Trypanosomiasis, African / Q000276:immunology*
chemical_list: D008075:Lipoproteins, HDL