title: Marked increase of neuronal prion protein immunoreactivity in Alzheimer's disease and human prion diseases.
abstract: In neurodegenerative disorders including Alzheimer's disease (AD), free radical damage to lipids, carbohydrates, proteins and DNA has been demonstrated to play a key pathogenetic role. In vitro studies have suggested a function of the cellular prion protein (PrPc) in the defense against oxidative stress. Therefore, we investigated the distribution of PrPc immunoreactivity in hippocampus (sectors CA4-CA1), subiculum (Sub), entorhinal (EC), and temporal cortex (TC) in sections from AD, human transmissible spongiform encephalopathy (TSE) and control brains. Compared to control cases, AD brains revealed an increase in the proportion of PrPc-immunoreactive neurons, which was statistically significant in CA2, Sub, and TC. In TSEs, a statistically significant increase of PrPc-immunoreactive neurons was observed in CA2, CA1, Sub, EC, and TC. In conclusion, our data show a striking up-regulation of PrPc in neurodegeneration and provide additional support for the concept that PrPc may be involved in the defense against oxidative stress.
authors.affiliation: Institute of Neurology, University of Vienna, Wien, Austria.
authors.forename: T
authors.initials: T
authors.lastname: Voigtländer
authors.forename: S
authors.initials: S
authors.lastname: Klöppel
authors.forename: P
authors.initials: P
authors.lastname: Birner
authors.forename: C
authors.initials: C
authors.lastname: Jarius
authors.forename: H
authors.initials: H
authors.lastname: Flicker
authors.forename: S
authors.initials: S
authors.lastname: Verghese-Nikolakaki
authors.forename: T
authors.initials: T
authors.lastname: Sklaviadis
authors.forename: M
authors.initials: M
authors.lastname: Guentchev
authors.forename: H
authors.initials: H
authors.lastname: Budka
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology* / Q000503:physiopathology; D001921:Brain / Q000473:pathology* / Q000503:physiopathology; D002452:Cell Count; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology*; D018384:Oxidative Stress / Q000502:physiology*; D018621:PrPC Proteins / Q000032:analysis*; D017096:Prion Diseases / Q000473:pathology* / Q000503:physiopathology; D015854:Up-Regulation / Q000502:physiology*
chemical_list: D018621:PrPC Proteins