Binding sites for the plant lectin Bandeiraea simplicifolia I-isolectin B(4) are expressed by nociceptive primary sensory neurones.
Circumstantial evidence suggests that binding sites for the plant lectin Bandeiraea simplicifolia I-isolectin B(4) are expressed by nociceptive primary sensory neurones. In order to test this hypothesis directly, we have used a combination of intracellular staining of functionally characterised primary sensory neurones and lectin binding. Consistent with the hypothesis, none of the low threshold primary sensory neurones we sampled expressed lectin binding sites, whilst a subpopulation of the nociceptive neurones did.
Gerke
M B
MB
Neuroscience Laboratory, School of Life Sciences, Queensland University of Technology, Brisbane, Queensland 4001, Australia.
Plenderleith
M B
MB
D000200:Action Potentials / Q000502:physiology; D000818:Animals; D001665:Binding Sites / Q000187:drug effects / Q000502:physiology; D005260:Female; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D037102:Lectins / Q000493:pharmacokinetics*; D008297:Male; D008465:Mechanoreceptors / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D018613:Microscopy, Confocal; D018482:Muscle, Skeletal / Q000294:innervation; D009412:Nerve Fibers / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D009413:Nerve Fibers, Myelinated / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure; D009431:Neural Conduction / Q000187:drug effects / Q000502:physiology; D009475:Neurons, Afferent / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009619:Nociceptors / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D010146:Pain / Q000378:metabolism* / Q000503:physiopathology; D010812:Physical Stimulation; D037121:Plant Lectins; D051381:Rats; D017208:Rats, Wistar; D011956:Receptors, Cell Surface / Q000187:drug effects / Q000378:metabolism*
C045475:Griffonia simplicifolia lectins; D037102:Lectins; D037121:Plant Lectins; D011956:Receptors, Cell Surface