In vivo lymphocyte activation and apoptosis by lectins of the Diocleinae subtribe.
This paper reports the overall effects of three lectins, extracted from Canavalia brasiliensis, Dioclea violacea, and D. grandiflora, on BALB/c mice popliteal draining lymph nodes. These lectins have presented high stimulatory capacity on lymph node T cells. Additionally, they were able to induce apoptosis and inflammation (frequently associated with high endothelial venule necrosis). The data presented here suggest that the Diocleinae lectins studied can stimulate in vivo T cell activation and apoptosis, as well as present important side effects.
Barbosa
T
T
Centro de Pesquisas Gonçalo Moniz-Fiocruz, 40295-001 Salvador, BA, Brasil.
Arruda
S
S
Cavada
B
B
Grangeiro
T B
TB
de Freitas
L A
LA
Barral-Netto
M
M
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000187:drug effects*; D002452:Cell Count; D004727:Endothelium / Q000098:blood supply; D007887:Fabaceae / Q000737:chemistry* / Q000235:genetics; D005260:Female; D007249:Inflammation / Q000139:chemically induced; D037102:Lectins / Q000494:pharmacology*; D008198:Lymph Nodes / Q000187:drug effects* / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009336:Necrosis; D037121:Plant Lectins; D010946:Plants, Medicinal; D015375:Receptors, Interleukin-2 / Q000378:metabolism; D014699:Venules / Q000473:pathology
D037102:Lectins; D037121:Plant Lectins; D015375:Receptors, Interleukin-2