TPU-0031-A and B, new antibiotics of the novobiocin group produced by Streptomyces sp. TP-A0556.
Two novel antibiotics, TPU-0031-A and B, were isolated from the culture broth of an actinomycete strain. The producing strain, TP-A0556, was identified as Streptomyces sp. based on the taxonomic study. The new antibiotics were obtained by solvent extraction and chromatographic purification. Spectroscopic analyses showed that TPU-0031-A and B were 7'-demethylnovobiocin and 5"-demethylnovobiocin, respectively. These compounds showed antibiotic activity against Gram-positive and -negative bacteria.
Sasaki
T
T
Biotechnology Research Center, Toyama Prefectural University, Kosugi, Japan.
Igarashi
Y
Y
Saito
N
N
Furumai
T
T
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D008855:Microscopy, Electron, Scanning; D009675:Novobiocin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D018547:Plant Stems / Q000382:microbiology; D013302:Streptomyces / Q000737:chemistry / Q000378:metabolism* / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; C433012:TPU-0031-A; C433013:TPU-0031-B; D009675:Novobiocin