title: Reversal of CSF positivity for JC virus genome by cidofovir in a patient with systemic lupus erythematosus and progressive multifocal leukoencephalopathy.
abstract: We report the case of a 36-year-old woman affected by systemic lupus erythematosus who developed rapidly progressive multifocal leukoencephalopathy. Cidofovir therapy induced disappearance of JC virus genome from the cerebrospinal fluid and stabilization of the MRI picture. Despite the fatal outcome after a few months of disease, cidofovir treatment deserves further testing as single antiviral therapy in HIV-negative PML patients.
authors.affiliation: National Neurological Institute C. Besta, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Salmaggi
authors.forename: E
authors.initials: E
authors.lastname: Maccagnano
authors.forename: A
authors.initials: A
authors.lastname: Castagna
authors.forename: S
authors.initials: S
authors.lastname: Zeni
authors.forename: F
authors.initials: F
authors.lastname: Fantini
authors.forename: P
authors.initials: P
authors.lastname: Cinque
authors.forename: M
authors.initials: M
authors.lastname: Savoiardo
mesh_terms: D000328:Adult; D000998:Antiviral Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001921:Brain / Q000187:drug effects* / Q000473:pathology / Q000821:virology; D000077404:Cidofovir; D003596:Cytosine / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives*; D004279:DNA, Viral / Q000134:cerebrospinal fluid*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007577:JC Virus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification*; D007968:Leukoencephalopathy, Progressive Multifocal / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000821:virology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000276:immunology; D008279:Magnetic Resonance Imaging; D063065:Organophosphonates; D009943:Organophosphorus Compounds / Q000008:administration & dosage* / Q000009:adverse effects; D051437:Renal Insufficiency / Q000276:immunology; D016896:Treatment Outcome
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D003596:Cytosine; D000077404:Cidofovir