title: Motor sequencing deficits in schizophrenia: a comparison with Parkinson's disease.
abstract: Motor abnormalities occur in schizophrenia (SZ) and may arise from striatal dysfunction. This study examined whether the pattern of performance on simple and complex motor abilities in SZ was similar to that of patients with Parkinson's disease (PD). Quantitative tests of speeded movement and motor and cognitive sequencing were used to assess 25 SZ, 16 PD, and 84 normal controls (NCs). Sequencing performance was also examined with motor rigidity taken into account. Compared with the NC group, the SZ and PD groups were impaired on measures of motor rigidity and motor sequencing. With rigidity accounted for, the SZ group was significantly more impaired than the PD group on motor sequencing; cognitive and motor processes contributed to the motor deficit. Cognitive sequencing performance predicted motor sequencing performance in PD but not SZ. Although both SZ and PD resulted in significant motor and cognitive sequencing deficits, the pattern and correlates of these deficits differ, suggesting that the affected neural systems underlying motor deficits in SZ are different from those involved in PD.
authors.affiliation: Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, California 94305-5723, USA. edie@stanford.edu
authors.forename: E V
authors.initials: EV
authors.lastname: Sullivan
authors.forename: R
authors.initials: R
authors.lastname: Fama
authors.forename: P K
authors.initials: PK
authors.lastname: Shear
authors.forename: D A
authors.initials: DA
authors.lastname: Cahn-Weiner
authors.forename: M
authors.initials: M
authors.lastname: Stein
authors.forename: R B
authors.initials: RB
authors.lastname: Zipursky
authors.forename: A
authors.initials: A
authors.lastname: Pfefferbaum
mesh_terms: D000328:Adult; D000368:Aged; D018680:Cholinergic Antagonists / Q000627:therapeutic use; D003072:Cognition Disorders / Q000453:epidemiology / Q000209:etiology; D003342:Corpus Striatum / Q000503:physiopathology; D005625:Frontal Lobe / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications* / Q000503:physiopathology; D011596:Psychomotor Disorders / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D012559:Schizophrenia / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D012720:Severity of Illness Index; D014888:Wechsler Scales
chemical_list: D018680:Cholinergic Antagonists