CD20-positive T cell leukemia/lymphoma: case report and review of the literature.
We report on a case of CD20-positive peripheral T cell lymphoma. The lymphoma cell was positive for CD20 and T cell lineage markers such as cytoplasmic CD3, CD4, and CD5 and had a monoclonal rearrangement of the T cell receptor (TCR) gamma chain gene. The clinical characteristics resembled angioimmunoblastic lymphadenopathy: spontaneous regression of lymphadenopathy and immunological abnormalities such as polyclonal hypergammaglobulinemia, positive results of direct and indirect antiglobulin tests, and a high antinuclear antibody titer. We reviewed seven cases of CD20-positive T cell malignancies including the present case. Three were immature T cell malignancies (acute lymphoblastic leukemia) and four were peripheral T cell malignancies (non-Hodgkin's lymphoma and chronic lymphocytic leukemia). Hepatomegaly and/or splenomegaly were common features. Further cases must be evaluated to understand the clinical significance of the CD20 expression on the surface of T cell malignancies.
Yokose
N
N
Third Department of Internal Medicine, Nippon Medical School, Tokyo, Japan.
Ogata
K
K
Sugisaki
Y
Y
Mori
S
S
Yamada
T
T
An
E
E
Dan
K
K
D018951:Antigens, CD20 / Q000032:analysis*; D019675:Genes, T-Cell Receptor gamma / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D015458:Leukemia, T-Cell / Q000473:pathology*; D008198:Lymph Nodes / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D018951:Antigens, CD20