The pharmacokinetics of diethanolamine in Sprague-Dawley rats following intravenous administration.
In order to better understand the potential toxicity of diethanolamine (DEA) and preparatory to physiologically-based pharmacokinetic model development, the pharmacokinetics of DEA at high and low internal dose through 96-h post-dosing were determined in female Sprague-Dawley rats administered 10 or 100 mg/kg uniformly labeled 14C-DEA via intravenous injection. Clearance of DEA from blood was calculated to be approximately 84 ml/h/kg at the low dose, increasing to approximately 242 ml/h/kg at the high dose. The primary route of excretion of administered radioactivity, approximately 25-36%, was via the urine as parent compound. A majority of the administered radioactivity was recovered in the tissues of treated rats, especially in the liver and kidneys, suggesting a propensity of DEA or its metabolites for bioaccumulation. An accumulation of radioactivity also occurred gradually in the red blood cells from about 6-96 h post-dosing. Some evidence of dose dependency in the fate of iv-administered DEA was observed, suggesting that saturation of the bioaccumulation process(es) occurred at a dose level of 100 mg/kg.
Mendrala
A L
AL
Toxicology and Environmental Research and Consulting, The Dow Chemical Company, Midland, MI 48674, USA.
Waechter
J M
JM
Bormett
G A
GA
Bartels
M J
MJ
Stott
W T
WT
D000818:Animals; D002247:Carbon Isotopes / Q000652:urine; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000378:metabolism; D004983:Ethanolamines / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000633:toxicity*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
D002247:Carbon Isotopes; D004983:Ethanolamines; C020283:diethanolamine