title: Life-threatening giant mediastinal goiter: a surgical challenge.
abstract: Mediastinal goiter is a well known benign disease, usually resectable through a cervical approach with minimal morbidity and mortality. Only occasionally a median sternotomy or a lateral thoracotomy may be required. The present case is worthy of presentation because of the exceptional dimension of the disease and the surgical challenge that it presented. In a 72-year-old woman a large intrathoracic goiter of the right thorax caused a severe dyspnoea due to an important contralateral mediastinal shift with compression of the lung, superior vena cava system and trachea. At surgical exploration, through a cervico-sternotomic approach, the mediastinal structures dislocation and the strong adherences between the anomalous neovascularized capsula of the mass and the surrounding structures, complicated the surgical dissection. An accidental lesion of the innominate artery required its reimplantation on the ascending aorta. An immense mass, was finally removed and pathological examination revealed a rare case of neovascularized, pseudosarcomatoid capsula among a benign hyperplastic proliferation. In spite of its benign nature, a giant goiter caused a life-threatening compression of the respiratory tract and lung parenchyma in this patient. The dimension of the lesions, the mediastinal anatomy alterations and the severe intraoperative haemorrhage represented major technical difficulties during surgical resection.
authors.affiliation: Department of Thoracic Surgery, European Institute of Oncology, Milan, Italy. giulia.veronesi@ieo.it
authors.forename: G
authors.initials: G
authors.lastname: Veronesi
authors.forename: F
authors.initials: F
authors.lastname: Leo
authors.forename: P G
authors.initials: PG
authors.lastname: Solli
authors.forename: M
authors.initials: M
authors.lastname: D'Aiuto
authors.forename: F
authors.initials: F
authors.lastname: D'Ovidio
authors.forename: G
authors.initials: G
authors.lastname: Mazzarol
authors.forename: L
authors.initials: L
authors.lastname: Spaggiari
authors.forename: U
authors.initials: U
authors.lastname: Pastorino
mesh_terms: D000368:Aged; D000402:Airway Obstruction / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D005260:Female; D005350:Fibroma / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D006045:Goiter, Substernal / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006801:Humans; D009389:Neovascularization, Pathologic / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011859:Radiography; D013249:Sternum / Q000601:surgery; D013961:Thyroid Gland / Q000098:blood supply / Q000473:pathology; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy / Q000379:methods*