[Study on thrombomodulin and plasminogen activator inhibitor type-1 in patients of pregnancy induced hypertension].
OBJECTIVE
To study the circulating levels of Thrombomodulin (TM) and Plasminogen activator inhibitor type-1 (PAI-1) in women with pregnancy induced hypertension (PIH) and normal pregnant women.


METHODS
Blood samples were withdrawn from 73 pregnant women, In which 25 mild PIH, 26 moderate PIH, 22 severe PIH were divided into study group, and 24 normotensive healthy pregnant women in their third trimester were control group. The determination of TM was measured by ELISA and PAI-1 by Colorimetric Assay methods.


RESULTS
Circulation levels of TM and PAI-1 were increased with increasing severity of the PIH. There were no significant differences between groups of mild PIH and normal pregnancy (TM 45.69 +/- 15.15 micrograms/L and 40.14 +/- 15.82 micrograms/L, PAI-1 22.06 +/- 12.13 kU/L and 18.40 +/- 9.78 kU/L respectively). The parameters significantly increased in moderate (TM 52.76 +/- 13.91 micrograms/L, PAI-1 25.77 +/- 9.45 kU/L) and severe PIH (TM 64.84 +/- 15.16 micrograms/L, PAI-1 30.79 +/- 11.64 kU/L) groups.


CONCLUSIONS
These results demonstrate that the endothelial cell damage and its functional disturbance play a very important role in the etiology of PIH. TM and PAI-1 may serve as clinical markers for the assessment of endothelial damage in PIH.
Ma
S
S
Peking Union Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730.
Bai
C
C
Bian
X
X
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D006801:Humans; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood*; D011247:Pregnancy; D018180:Thrombomodulin / Q000097:blood*
D015415:Biomarkers; D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin