title: [Ethmoid adenocarcinomas: retrospective study of 76 patients].
abstract: From the retrospective study of 76 adenocarcinomas of the ethmoid sinuses, results were expressed in two terms: the morbidity related to surgery and the oncologic outcome. This case study extends between 1975 and 2000. It includes 71 men and 5 women, with an average of 61 years. 81% of them works in wood dust, with a mean duration of exposure of 26 years. The diagnosis of adenocarcinoma is realized in the three months after the first signs, essentially rhinologicals, next neurologicals and ophthalmologicals. The majority of tumors were classified as T3N0M0, i.e. 57.89%. The treatment of this tumors is surgical: 34.2% surgical only and 59.2% with radiotherapy. The transfacial approach (paralateronasal and degloving) and the combined surgery are respectively performed in 36 patients and 35 patients. 23.2% patients had a local recurrence, and 10% developed cervical nodes and systemic metastasis. Survival rate based on the Kaplan-Meier actuarial method is 82% at 3 years, 80% at 5 years, 72% at 10 years. The prognosis of ethmoidal cancer is strictly correlated to local control. Local recurrence is statistically more likely in patients with involvement of the dura, brain and sphenoid sinus. With the analysis of the carcinologics results, we discuss the therapeutics indications of the adenocarcinomas and a new classification. Taking in account the involvement of the dura, sphenoid and orbit. We did not find any statistical differences between T3 patients treated by combined approach (n = 13) or by transfacial approach (n = 15).
authors.affiliation: C.H.U. Pellegrin, Clinique Universitaire O.R.L., Place Amélie Raba Léon, 33076 Bordeaux, France.
authors.forename: D
authors.initials: D
authors.lastname: Stoll
authors.forename: J P
authors.initials: JP
authors.lastname: Bébéar
authors.forename: Y
authors.initials: Y
authors.lastname: Truilhé
authors.forename: V
authors.initials: V
authors.lastname: Darrouzet
authors.forename: N
authors.initials: N
authors.lastname: David
mesh_terms: D000206:Actuarial Analysis; D000230:Adenocarcinoma / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D003131:Combined Modality Therapy; D004391:Dust / Q000009:adverse effects; D005005:Ethmoid Sinus; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009367:Neoplasm Staging; D009784:Occupational Diseases / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D016273:Occupational Exposure / Q000009:adverse effects; D010255:Paranasal Sinus Neoplasms / Q000145:classification / Q000175:diagnosis* / Q000209:etiology / Q000401:mortality / Q000601:surgery*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D016019:Survival Analysis; D016896:Treatment Outcome; D014934:Wood
chemical_list: D004391:Dust