Development of tolerance to the antiaggressive effects of morphine.
Many reports have demonstrated that there is a development of tolerance to many effects produced by morphine. This study was conducted with the aim of determining whether the antiaggressive actions of morphine develop tolerance after chronic administration. Acute morphine administration produced antiaggressive effects which disappeared after chronic (7 days) treatment in isolated mice. An increase in non-social exploration was observed, representing morphine-induced hyperactivity, after acute treatment, which was not present after chronic administration. In conclusion, there is a development of tolerance to the antiaggressive and motor effects of morphine.
Rodríguez-Arias
M
M
Area de Psicobiología, Facultad de Psicología, Universitat de València, Spain.
Miñarro
J
J
Simón
V M
VM
D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D012919:Social Behavior
D009020:Morphine