title: Genetic and phenotypic characterization of macrolide resistance in group A streptococci isolated from adults with pharyngo-tonsillitis in France.
abstract: Three hundred and three strains of group A streptococci (GAS) isolated from adults with pharyngitis were tested to evaluate their phenotype of resistance to macrolides-lincosamides and to search for macrolide resistance genes. MICs of clarithromycin were determined. The overall rate of resistance to both erythromycin and clarithromycin was 9.6%. Constitutive, inducible and M phenotypes of resistance were detected in 4.3, 2 and 3.3% of strains, respectively. All constitutive phenotypes harboured ermB genes, whereas inducible phenotypes had the ermTR gene and M phenotypes had the mefA gene. In France, the current resistance rate of GAS to erythromycin and clarithromycin remains low.
authors.affiliation: Laboratoire de Biologie Médicale BIO VSM, 10 rue de la Gare, F-77360 Vaires-sur-Marne, France. pweber.biovsm@wanadoo.fr
authors.forename: P
authors.initials: P
authors.lastname: Weber
authors.forename: J
authors.initials: J
authors.lastname: Filipecki
authors.forename: E
authors.initials: E
authors.lastname: Bingen
authors.forename: F
authors.initials: F
authors.lastname: Fitoussi
authors.forename: G
authors.initials: G
authors.lastname: Goldfarb
authors.forename: J P
authors.initials: JP
authors.lastname: Chauvin
authors.forename: C
authors.initials: C
authors.lastname: Reitz
authors.forename: H
authors.initials: H
authors.lastname: Portier
mesh_terms: D000234:Adenoids / Q000187:drug effects / Q000382:microbiology; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use; D002648:Child; D024881:Drug Resistance, Bacterial / Q000235:genetics*; D005602:France; D006801:Humans; D018942:Macrolides; D010641:Phenotype; D013290:Streptococcal Infections / Q000188:drug therapy / Q000235:genetics* / Q000382:microbiology; D013297:Streptococcus pyogenes / Q000187:drug effects / Q000235:genetics* / Q000302:isolation & purification; D014069:Tonsillitis / Q000188:drug therapy / Q000235:genetics* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D018942:Macrolides