Abnormal neuronal network in anorexia nervosa studied with I-123-IMP SPECT.
Single photon emission computed tomography was used to study 14 female patients with anorexia nervosa and 8 female normal comparison subjects. Automatic voxel-based analysis of the images was carried out using statistical parametric mapping (SPM) software. Statistics across the entire brain were displayed as Z scores (threshold: P<0.05). Compared with the normal comparison subjects, the anorectic patients were characterized by hypoperfusion in the medial prefrontal cortex and the anterior cingulate gyrus, and hyperperfusion in the thalamus and the amygdala-hippocampus complex. These results suggest that a dysfunction in neuronal circuitry may be related to anorexia nervosa.
Takano
A
A
Department of Nuclear Medicine, Hokkaido University School of Medicine, Kita 15 Nishi 7, Kita-ku, 060-8638, Sapporo, Japan.
Shiga
T
T
Kitagawa
N
N
Koyama
T
T
Katoh
C
C
Tsukamoto
E
E
Tamaki
N
N
D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D001931:Brain Mapping / Q000379:methods*; D016022:Case-Control Studies; D002560:Cerebrovascular Circulation; D005260:Female; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D007457:Iodine Radioisotopes; D009415:Nerve Net / Q000503:physiopathology*; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime; D013702:Temporal Lobe / Q000098:blood supply; D013788:Thalamus / Q000098:blood supply; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods
D007457:Iodine Radioisotopes; D019275:Radiopharmaceuticals; D019690:Technetium Tc 99m Exametazime