[Epidemiological analysis on the risk factors of intrauterine transmission of hepatitis virus C].
OBJECTIVE
To investigate the possibility and risk factors of intrauterine transmission of hepatitis virus C (HCV) in Taiyuan City.


METHODS
Anti-HCV and HCV RNA were detected by enzyme linked immunosorbent assay(ELISA) and reverse transcriptase Polymerase Chain Reaction(RT-PCR), in 64 mothers with HCV or HCV RNA positive and their newborns cord blood samples. Case-control study was used for the risk factors analysis.


RESULTS
The infection rate of HCV was 66.15% in newborns from anti-HCV or HCV RNA positive mothers. The intrauterine transmission rate was 100% in newborns from HCV RNA positive mothers. There was a significant correlation between HCV intrauterine transmission and maternal history of blood transfusion and abnormal serum alanine aminotransferase(ALT), and the relative risk was 317.15 and 2.60, respectively.


CONCLUSIONS
The higher incidence of intrauterine transmission was found in newborns from HCV RNA or anti-HCV positive mothers. The high risk factors of intrauterine transmission are maternal blood transfusion history and abnormal ALT.
Bai
G
G
Taiyuan Infectious Hospital, Taiyuan 030012.
Wang
S
S
Feng
L
L
D000914:Antibodies, Viral / Q000097:blood; D016022:Case-Control Studies; D002681:China / Q000453:epidemiology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D016174:Hepacivirus / Q000276:immunology / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology / Q000635:transmission*; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D011247:Pregnancy; D012367:RNA, Viral / Q000097:blood; D020133:Reverse Transcriptase Polymerase Chain Reaction; D012307:Risk Factors
D000914:Antibodies, Viral; D012367:RNA, Viral