Mechanisms governing bone metastasis in prostate cancer.
Why does prostate cancer metastasize to bone? Why is there increased turnover of the bone matrix in the presence of prostate cancer? A recent autopsy study supports a traditional hypothesis that gross, anatomic patterns of blood flow influence the distribution of metastatic deposits. On the other hand, recent developments in animal models of prostate cancer bone metastasis have renewed interest in the traditional 'seed and soil' hypothesis: several studies point to specific biological interactions between prostate cancer cells and the bone microenvironment that can explain the tendency of prostate cancer cells to colonize bone and grow into clinically relevant metastatic deposits. Some studies implicate mechanisms including chemoattraction and enhanced adherence to bone endothelium. Additional data suggest that prostate cancer cells are 'osteomimetic', that is, they take on the properties and behaviors of osteoblasts or osteoclasts upon arrival in bone. These activities lead to enhanced turnover of the bone matrix and may explain the propensity of prostate cancer to grow in bone. Finally, a series of studies have implicated other molecular markers as distinguishing characteristics of bone-metastatic prostate cancer tissue.
Cher
M L
ML
Departments of Urology and Pathology, Wayne State University and The Barbara Ann Karmanos Cancer Institute, Detroit, Michigan, USA. mcher@med.wayne.edu
D000818:Animals; D001859:Bone Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000556:secondary*; D006801:Humans; D015994:Incidence; D008297:Male; D009361:Neoplasm Invasiveness; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D011471:Prostatic Neoplasms / Q000473:pathology*; D018570:Risk Assessment