title: [Clinical and histopathological characteristics of early Leser-Trélat syndrome].
abstract: Leser-Trélat-syndrome is characterized as the eruptive appearance of multiple seborrheic keratoses in association with underlying malignant disease. A 73 year old female patient with a metastatic adenocarcinoma of the colon presented with this paraneoplastic change. The rapid appearance of solitary seborrheic keratoses with associated inflammation, seen clinically and histologically, may be an early sign of Leser-Trélat-syndrome. The recognition of this inflammatory component as an early sign may contribute to the prompt diagnosis of this paraneoplasia, even before the eruption of numerous seborrheic keratoses.
authors.affiliation: Hautklinik, Klinikum Kassel, Akademisches Lehrkrankenhaus, Philipps-Universität Marburg.
authors.forename: G
authors.initials: G
authors.lastname: Barth
authors.forename: O
authors.initials: O
authors.lastname: Basten
authors.forename: J
authors.initials: J
authors.lastname: Rüschoff
authors.forename: R
authors.initials: R
authors.lastname: Rompel
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000627:therapeutic use; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D003113:Colonoscopy; D003937:Diagnosis, Differential; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D017492:Keratosis, Seborrheic / Q000175:diagnosis* / Q000473:pathology; D008207:Lymphatic Metastasis; D010166:Palliative Care; D010257:Paraneoplastic Syndromes / Q000175:diagnosis* / Q000473:pathology; D012867:Skin / Q000473:pathology; D013577:Syndrome; D013997:Time Factors
chemical_list: D000964:Antimetabolites, Antineoplastic; D005472:Fluorouracil