Spironolactone-induced hepatitis.
There is widespread use of spironolactone in medical practice and the indications for its use well established and side effect profile well known. Herein, we present a case of drug-induced hepatitis occurring in a 50-year-old woman using spironolactone for the treatment of androgenetic alopecia. Six weeks after commencement of spironolactone the patient became unwell, complained of an extensive itch, but no icterus or jaundice. Liver function tests found abnormally elevated bilirubin and enzymes levels. After withdrawal of spironolactone, the patient's symptoms resolved and liver function improved. To date, there has only been one other report of spironolactone-induced hepatitis.
Thai
K E
KE
Department of Medicine (Dermatology), The University of Melbourne, St Vincent's Hospital, Melbourne, Victoria, Australia.
Sinclair
R D
RD
D000505:Alopecia / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D005260:Female; D006801:Humans; D008111:Liver Function Tests; D008875:Middle Aged; D000451:Mineralocorticoid Receptor Antagonists / Q000009:adverse effects*; D013148:Spironolactone / Q000009:adverse effects*
D000451:Mineralocorticoid Receptor Antagonists; D013148:Spironolactone