title: beta -Helical polymers from isocyanopeptides.
abstract: Polymerization of isocyanopeptides results in the formation of high molecular mass polymers that fold in a proteinlike fashion to give helical strands in which the peptide chains are arranged in beta-sheets. The beta-helical polymers retain their structure in water and unfold in a cooperative process at elevated temperatures. The peptide architecture in these polymers is a different form of the beta-helix motif found in proteins. Unlike their natural counterparts, which contain arrays of large beta-sheets stacked in a helical fashion, the isocyanopeptide polymers have a central helical core that acts as a director for the beta-sheet-like arrangement of the peptide side arms. The helical structure of these isocyanopeptide polymers has the potential to be controlled through tailoring of the side branches and the hydrogen-bonding network present in the beta-sheets.
authors.affiliation: Department of Organic Chemistry, University of Nijmegen, Toernooiveld 1, 6525 ED Nijmegen, Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Cornelissen
authors.forename: J J
authors.initials: JJ
authors.lastname: Donners
authors.forename: R
authors.initials: R
authors.lastname: de Gelder
authors.forename: W S
authors.initials: WS
authors.lastname: Graswinckel
authors.forename: G A
authors.initials: GA
authors.lastname: Metselaar
authors.forename: A E
authors.initials: AE
authors.lastname: Rowan
authors.forename: N A
authors.initials: NA
authors.lastname: Sommerdijk
authors.forename: R J
authors.initials: RJ
authors.lastname: Nolte
mesh_terms: D000409:Alanine / Q000737:chemistry*; D002942:Circular Dichroism; D003486:Cyanides / Q000737:chemistry*; D006860:Hydrogen Bonding; D009682:Magnetic Resonance Spectroscopy; D018625:Microscopy, Atomic Force; D008968:Molecular Conformation; D009842:Oligopeptides / Q000737:chemistry; D010455:Peptides / Q000737:chemistry*; D011108:Polymers / Q000737:chemistry; D017510:Protein Folding; D017433:Protein Structure, Secondary; D013055:Spectrophotometry, Infrared; D013696:Temperature; D014269:Trifluoroacetic Acid; D014867:Water / Q000737:chemistry
chemical_list: D003486:Cyanides; D009842:Oligopeptides; D010455:Peptides; D011108:Polymers; D014867:Water; D014269:Trifluoroacetic Acid; D000409:Alanine