[TAFI--thrombin activated fibrinolysis inhibitor ].
This is a review of literature data concerning Thrombin Activatable Fibrinolysis Inhibitor (TAFI) and its role in haemostatic system in vitro and in vivo. This is the glycoprotein, which was identified recently by three independent groups of researchers. TAFI is converted to its active form by thrombin-thrombomodulin complex. TAFIa removes lysine residues from fibrin net, making impossible formation of plasminogen, t-PA and fibrin complex. It causes impairment of plasmin generation, and by this way suppression of fibrinolysis.
Hryszko
T
T
Klinika Nefrologii i Chorób Wewnetrznych Akademia Medyczna w Białymstoku. tomhry@poczta.onet.pl
Małyszko
J
J
Brzósko
S
S
Myśliwiec
M
M
D000818:Animals; D025901:Carboxypeptidase B2; D002268:Carboxypeptidases / Q000378:metabolism*; D005341:Fibrinolysin / Q000096:biosynthesis; D006487:Hemostasis / Q000502:physiology*; D006801:Humans
D002268:Carboxypeptidases; D025901:Carboxypeptidase B2; D005341:Fibrinolysin