Bone mineral content and bone mineral density in adolescent girls with anorexia nervosa--a longitudinal study.
OBJECTIVE
Total body and lumbar spine bone mineral density (BMD-TB, BMD-L) and total body bone mineral content (BMC-TB) were measured to establish the course of bone demineralization in anorexia nervosa and the clinical factors influencing BMC-TB and BMD changes during treatment.


METHODS
Forty-two girls with DSM III-R anorexia nervosa, age 14.7+/-2.4 years. BMC-TB, BMD-TB and BMD-L were measured in approximately 7-month intervals for 27.8+/-4.1 months using DXA.


RESULTS
Despite nutritional improvement, there was an initial decrease of BMD-L, and no change in BMC-TB and BMD-TB. an increase in BMC-TB and BMD was observed after approx. 21 months from the beginning of the study.


CONCLUSIONS
The improvement in BMC-TB and BMD was related to changes in nutritional status and was significantly marked in younger patients, with earlier anorexia onset and before menarche.
Jagielska
G
G
Department of Child Psychiatry and Department of Internal Medicine and Nephrology, Medical University of Warsaw, Poland.
Wolańczyk
T
T
Komender
J
J
Tomaszewicz-Libudzic
C
C
Przedlacki
J
J
Ostrowski
K
K
D000293:Adolescent; D000328:Adult; D000855:Anorexia / Q000150:complications*; D018488:Bone Demineralization, Pathologic / Q000209:etiology*; D015519:Bone Density; D002648:Child; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008159:Lumbar Vertebrae / Q000737:chemistry; D008572:Menarche; D009752:Nutritional Status