title: Gold(III) chloride catalyzed cyclization of alpha-hydroxyallenes to 2,5-dihydrofurans.
abstract: [reaction: see text] Functionalized alpha-hydroxyallenes 1 were smoothly converted into the corresponding 2,5-dihydrofurans 2 by using 5-10 mol % of gold(III) chloride as catalyst. This mild and efficient cyclization method can be applied to alkyl- and alkenyl-substituted allenes at room temperature, furnishing tri- and tetrasubstituted dihydrofurans in good to excellent chemical yields and with complete axis to center chirality transfer.
authors.affiliation: Organic Chemistry II, Dortmund University, D-44221 Dortmund, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Hoffmann-Röder
authors.forename: N
authors.initials: N
authors.lastname: Krause