Inducible nitric oxide synthase and Salmonella infection.
Salmonella infection is associated with the increased expression of inducible nitric oxide synthase in macrophages and other cells. This review summarizes current knowledge of the molecular mechanisms involved in the induction process, and discusses the functional significance of nitric oxide production in the context of host defense against Salmonella.
Cherayil
B J
BJ
Mucosal Immunology Laboratory, Combined Program in Pediatric Gastroenterology and Nutrition, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA. cherayil@helix.mgh.harvard.edu
Antos
D
D
D000818:Animals; D002460:Cell Line; D006801:Humans; D008264:Macrophages / Q000201:enzymology / Q000382:microbiology*; D051379:Mice; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000378:metabolism*; D052247:Nitric Oxide Synthase Type II; D012475:Salmonella / Q000276:immunology / Q000502:physiology*; D012480:Salmonella Infections / Q000201:enzymology* / Q000276:immunology / Q000382:microbiology*; D012481:Salmonella Infections, Animal / Q000201:enzymology / Q000276:immunology / Q000382:microbiology
D009569:Nitric Oxide; C496319:NOS2 protein, human; D019001:Nitric Oxide Synthase; D052247:Nitric Oxide Synthase Type II; C496317:Nos2 protein, mouse