CGH analysis of ductal carcinoma of the breast with basaloid/myoepithelial cell differentiation.
2-18% of ductal carcinoma-No Special Type (NST) are reported to express basal cell keratin 14 and such tumours may have a different metastatic pattern and prognosis. We performed immunohistochemistry for cytokeratins 19 (luminal) and 14 (basal) on 92 ductal carcinoma-NST. Those tumours showing CK14 expression were further characterized by immunohistochemistry for myoepithelial cell phenotype and analysed by comparative genomic hybridization. The 7 cases of ductal carcinoma-NST exhibiting a basal cell phenotype were all grade III tumours and showed a molecular cytogenetic profile similar to more conventional myoepithelial cell carcinomas. Therefore it appears that grade III invasive ductal carcinomas contain a subset of tumours with specific morphological and cytogenetic characteristics, and probably prognosis for the patient.
Jones
C
C
The Ludwig Institute for Cancer Research/UCL Breast Molecular Pathology Group, Royal Free & University College Medical School, UK.
Nonni
A V
AV
Fulford
L
L
Merrett
S
S
Chaggar
R
R
Eusebi
V
V
Lakhani
S R
SR
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000378:metabolism; D001943:Breast Neoplasms / Q000378:metabolism / Q000473:pathology*; D002280:Basal Cell Carcinoma / Q000378:metabolism / Q000473:pathology*; D018270:Carcinoma, Ductal, Breast / Q000378:metabolism / Q000473:pathology*; D002454:Cell Differentiation; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009208:Myoepithelioma / Q000378:metabolism / Q000473:pathology*; D009363:Neoplasm Proteins / Q000378:metabolism; D009367:Neoplasm Staging; D009693:Nucleic Acid Hybridization; D011379:Prognosis
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D007633:Keratins