Anti-inflammatory and analgesic activity of Hypericum empetrifolium Willd. (Guttiferae).
A methanolic extract of Hypericum empetrifolium Willd. was evaluated for anti-inflammatory properties in rats (subplantar edema induced by carrageenan) and analgesic effects in mice (hot plate and writhing tests). Our results showed that the methanolic extract exhibits a significant anti-inflammatory activity and analgesic effects only in one of the experimental models (writhing test). Therefore, we may suppose that the methanolic extract of H. empetrifolium is active against inflammatory pain.
Trovato
A
A
Pharmaco-Biological Department, School of Pharmacy, University of Messina, Italy.
Raneri
E
E
Kouladis
M
M
Tzakou
O
O
Taviano
M F
MF
Galati
E M
EM
D018712:Analgesics, Non-Narcotic / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000473:pathology; D020902:Hypericum / Q000737:chemistry*; D007274:Injections, Intraperitoneal; D008297:Male; D000432:Methanol; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D018712:Analgesics, Non-Narcotic; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D002351:Carrageenan; D000432:Methanol