title: Non-linear dynamic analysis of clozapine-induced electroencephalographic changes in schizophrenic patients--a preliminary study.
abstract: 1. In order to find the electroencephalographic (EEG) parameters that reflect the effect of clozapine in schizophrenic patients, the authors applied various non-linear analyses on multi-channel EEG data drawn from patients before and after a therapeutic trial of clozapine. 2. The correlation dimension was difficult to extract from our limited time series EEG data and the authors did not find a meaningful association with clozapine use. The primary Lyapunov exponent could be reliably calculated but also did not reflect the effect of clozapine. 3. However, the mutual cross-prediction (MCP) algorithm showed potentially meaningful results. The driving system was shifted to the frontal channels after a 4-week trial with clozapine. Moreover, MCP might have a value as a predictor of treatment response. 4. Although preliminary in nature, the MCP might have greater power for interpreting complex changes from channel to channel in EEG induced by clozapine.
authors.affiliation: Department of Psychiatry, Seoul National University College of Medicine, Korea.
authors.forename: U G
authors.initials: UG
authors.lastname: Kang
authors.forename: K T
authors.initials: KT
authors.lastname: Par
authors.forename: Y M
authors.initials: YM
authors.lastname: Ahn
authors.forename: Y J
authors.initials: YJ
authors.lastname: Koo
authors.forename: S C
authors.initials: SC
authors.lastname: Yoon
authors.forename: S H
authors.initials: SH
authors.lastname: Yi
authors.forename: Y S
authors.initials: YS
authors.lastname: Kim
mesh_terms: D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D003024:Clozapine / Q000494:pharmacology* / Q000627:therapeutic use*; D004569:Electroencephalography / Q000187:drug effects* / Q000379:methods; D005260:Female; D006801:Humans; D008297:Male; D017711:Nonlinear Dynamics; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D014150:Antipsychotic Agents; D003024:Clozapine