Antibiotic resistance in Salmonella enterica serovar Typhimurium exposed to microcin-producing Escherichia coli.
Microcin 24 is an antimicrobial peptide secreted by uropathogenic Escherichia coli. Secretion of microcin 24 provides an antibacterial defense mechanism for E. coli. In a plasmid-based system using transformed Salmonella enterica, we found that resistance to microcin 24 could be seen in concert with a multiple-antibiotic resistance phenotype. This multidrug-resistant phenotype appeared when Salmonella was exposed to an E. coli strain expressing microcin 24. Therefore, it appears that multidrug-resistant Salmonella can arise as a result of an insult from other pathogenic bacteria.
Carlson
S A
SA
Preharvest Food Safety and Enteric Disease Research Unit, National Animal Disease Center, U.S. Department of Agriculture Agricultural Research Service, Ames, Iowa 50010, USA. scarlson@nadc.ars.usda.gov
Frana
T S
TS
Griffith
R W
RW
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001430:Bacteriocins / Q000378:metabolism* / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics / Q000254:growth & development
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; C020411:microcin