title: Synthesis and pharmacological activity of metabolites of the 5-HT(4) receptor antagonist SB-207266.
abstract: Three metabolites of N-[(1-butyl-4-piperidinyl)methyl]-3,4-dihydro-2H-[1,3]-oxazino[3,2_a]indole-10-carboxamide (SB-207266) (1) were synthesised and their pharmacological activity determined.
authors.affiliation: Department of Synthetic Chemistry, Smithkline Beecham Pharmaceuticals, New Frontiers Science Park, Essex CM19 5AW, Harlow, UK. Michael_fedouloff@sbphrd.com
authors.forename: M
authors.initials: M
authors.lastname: Fedouloff
authors.forename: F
authors.initials: F
authors.lastname: Hossner
authors.forename: M
authors.initials: M
authors.lastname: Voyle
authors.forename: J
authors.initials: J
authors.lastname: Ranson
authors.forename: J
authors.initials: J
authors.lastname: Powles
authors.forename: G
authors.initials: G
authors.lastname: Riley
authors.forename: G
authors.initials: G
authors.lastname: Sanger
mesh_terms: D000818:Animals; D006168:Guinea Pigs; D006801:Humans; D007211:Indoles / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D010880:Piperidines / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism; D011869:Radioligand Assay; D011985:Receptors, Serotonin / Q000378:metabolism*; D044422:Receptors, Serotonin, 5-HT4; D012702:Serotonin Antagonists / Q000138:chemical synthesis* / Q000737:chemistry / Q000378:metabolism
chemical_list: D007211:Indoles; D010880:Piperidines; D011985:Receptors, Serotonin; C096919:SB 207266; D012702:Serotonin Antagonists; D044422:Receptors, Serotonin, 5-HT4