Pathogenic trickery: deception of host cell processes.
Microbial pathogens cause a spectrum of diseases in humans. Although the disease mechanisms vary considerably, most pathogens have developed virulence factors that interact with host molecules, often usurping normal cellular processes, including cytoskeletal dynamics and vesicle targeting. These virulence factors often mimic host molecules, and mediate events as diverse as bacterial invasion, antiphagocytosis, and intracellular parastism.
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Biotechnology Laboratory, Room 237-6174 University Boulevard, University of British Columbia, Vancouver, British Columbia, Canada, V6T 1Z3.
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D000818:Animals; D001419:Bacteria / Q000235:genetics; D001422:Bacterial Adhesion; D001424:Bacterial Infections / Q000382:microbiology / Q000473:pathology; D018407:Bacterial Physiological Phenomena; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D005057:Eukaryotic Cells / Q000382:microbiology / Q000648:ultrastructure; D020558:GTP Phosphohydrolases / Q000502:physiology; D006801:Humans; D008024:Ligands; D008322:Mammals / Q000382:microbiology; D018716:Molecular Mimicry; D010587:Phagocytosis; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction; D014617:Vacuoles / Q000382:microbiology; D014774:Virulence
D001426:Bacterial Proteins; D008024:Ligands; D011956:Receptors, Cell Surface; D020558:GTP Phosphohydrolases