Chemopreventive activity of isoquinoline alkaloids from Corydalis plants.
Eighteen isoquinoline alkaloids including protoberberines (1-12), benzophenanthridines (13-16) and an aporphine (17) isolated from plants of Corydalis species (Fumariaceae) were tested for inhibitory effects on Epstein-Barr virus early antigen activation induced by 12-O-tetradecanoylphorbol 13-acetate in Raji cells. In a primary screening test, all of the isoquinoline alkaloids showed inhibitory activity with the IC50 values being in the range of 140-410 mol ratio/32 pmol TPA. The data demonstrate that these isoquinoline alkaloids might be valuable as anti-tumor promoters.
Ito
C
C
Itoigawa
M
M
Tokuda
H
H
Kuchide
M
M
Nishino
H
H
Furukawa
H
H
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000956:Antigens, Viral / Q000378:metabolism; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000975:Antioxidants / Q000737:chemistry / Q000302:isolation & purification; D001060:Aporphines / Q000737:chemistry* / Q000302:isolation & purification; D001600:Berberine Alkaloids / Q000737:chemistry / Q000302:isolation & purification; D002460:Cell Line; D018890:Chemoprevention; D004854:Herpesvirus 4, Human / Q000187:drug effects*; D007546:Isoquinolines / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015394:Molecular Structure; D010207:Papaver / Q000737:chemistry*; D010617:Phenanthridines / Q000737:chemistry / Q000302:isolation & purification; D010946:Plants, Medicinal
D000470:Alkaloids; D000956:Antigens, Viral; D000972:Antineoplastic Agents, Phytogenic; D000975:Antioxidants; D001060:Aporphines; D001600:Berberine Alkaloids; C033305:Epstein-Barr virus early antigen; D007546:Isoquinolines; D010617:Phenanthridines; C081279:aporphine; C009090:protoberberine