Origins and treatment of airway inflammation in childhood asthma.
Several early events and risk factors are associated with the development of childhood asthma. Two significant risk factors are viral lower respiratory tract infections and atopy. Studies suggest that imbalances in TH1/TH2 cytokine responses in relationship to viral infections may play a role in the development of the childhood asthmatic phenotype. Airway inflammation is now recognized to contribute to the inception, persistence, and severity of asthmatic symptoms. The majority of information pertaining to airway inflammation in asthma has been derived from adult studies, but recent evaluations have been done in children. Available data are inconclusive as to the right medication to be used at the inception and during the evolution of the asthmatic phenotype in children. Inhaled corticosteroids (ICS) are not consistently effective in young children for a variety of reasons, including underlying pathophysiologic mechanisms that are unresponsive to the pharmacologic properties of ICS. The leukotriene receptor antagonists (LTRAs), recently approved for children as young as 2 years of age, address the relationship between leukotriene production and airway inflammation or remodeling in asthma. Therapeutic trials using LTRAs in children should prove beneficial.
Lemanske
R F
RF
Departments of Pediatrics and Medicine, University of Wisconsin Medical School, Madison, Wisconsin, USA.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000209:etiology; D002648:Child; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000150:complications / Q000276:immunology; D007111:Immunity, Cellular; D007249:Inflammation / Q000150:complications / Q000188:drug therapy; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D015289:Leukotrienes / Q000502:physiology; D012141:Respiratory Tract Infections / Q000150:complications; D012307:Risk Factors
D000305:Adrenal Cortex Hormones; D020024:Leukotriene Antagonists; D015289:Leukotrienes