Delayed-type hypersensitivity and humoral immunity modulation by dietary lipids in a murine model of pulmonary tumorigenesis induced by urethan.
Mice fed on semisynthetic formulas containing 15% of corn oil (CO), cod fish liver oil (FO), oleic acid (O) or a mixture of 46% of palmitic and 50% of stearic acids (PS) were treated with urethan during 18 weeks for lung tumor induction. Delayed-type hypersensitivity (DTH) assay, hemagglutination assay and the amount of lung nodes (alveolar adenocarcinomas) were recorded. Results showed significantly greater DTH in CO and FO with respect to O and PS feeding mice; the two last ones induced an essential fatty acid (EFA) deficiency (EFAD). In the O lot there was a non-significant diminution of the humoral response. EFAD animals exhibited a tendency to increase number of lung nodes in relation to CO and FO lots. Splenomegalia was recorded in FO lot. Confront between spleen weight and DTH showed a 72% correlation, suggesting an increase in cellular immunity as increasing unsaturation. It may be concluded that in this suitable model of tumorigenesis the manipulation of dietary lipids may be a strategy to modify the immune system response.
Piegari
M
M
Instituto de Biología Celular, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Argentina.
Salvador
A F
AF
Muñoz
S E
SE
Valentich
M A
MA
Eynard
A R
AR
D000230:Adenocarcinoma / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002273:Carcinogens / Q000633:toxicity; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage* / Q000032:analysis; D004195:Disease Models, Animal; D005228:Fatty Acids, Essential / Q000008:administration & dosage* / Q000172:deficiency; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000187:drug effects*; D008175:Lung Neoplasms / Q000139:chemically induced / Q000276:immunology / Q000473:pathology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011897:Random Allocation; D014520:Urethane / Q000633:toxicity; D015430:Weight Gain / Q000187:drug effects
D002273:Carcinogens; D004042:Dietary Fats, Unsaturated; D005228:Fatty Acids, Essential; D014520:Urethane