A new tetrahydroprotoberberine N-oxide alkaloid and anti-platelet aggregation constituents of Corydalis tashiroi.
A new tetrahydroprotoberberine N-oxide alkaloid, (-)-cis-isocorypalmine N-oxide (1), together with two known compounds, 6-methoxydihydrosanguinarine (2) and norjuziphine (3), were isolated in continuing studies of the entire Formosan Corydalis tashiroi plant. The structures of these three compounds were determined through spectral analyses. In addition, compounds 1, 2, 3 and the seven alkaloids previously reported: (-)-cis-corydalmine N-oxide, (-)-trans-corydalmine N-oxide, (-)-trans-isocorypalmine N-oxide, scoulerine, protopine, oxysanguinarine and corydalmine, were found to possess antiplatelet aggregation activity.
Chen
J J
JJ
Department of Pharmacy, Tajen Institute of Technology, Pingtung, Taiwan, Republic of China.
Chang
Y L
YL
Teng
C M
CM
Lin
W Y
WY
Chen
Y C
YC
Chen
I S
IS
D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D053119:Benzophenanthridines; D001600:Berberine Alkaloids / Q000097:blood / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal; D007546:Isoquinolines; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D010617:Phenanthridines; D010936:Plant Extracts; D010946:Plants, Medicinal; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification / Q000494:pharmacology*; D011817:Rabbits
C438021:6-methoxydihydrosanguinarine; D000470:Alkaloids; D053119:Benzophenanthridines; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; D007546:Isoquinolines; D010617:Phenanthridines; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; C438022:isocorypalmine N-oxide; C438020:norjuziphine