G-2964A and C734A genetic polymorphisms of CYP1A2 in Chinese population.
OBJECTIVE
To observe the G-2964A and C734A genetic polymorphisms of human CYP1A2 in Chinese population.


METHODS
Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was employed in genotyping analysis.


RESULTS
The allele frequencies of A-2964 were 0.25 and 0.22 in Qidong and Changsha populations, respectively. The incidences of A734 were 0.68 in Qidong population and 0.66 in Changsha population. No more than two low-inducibility/activity alleles were presented in one person.


CONCLUSIONS
The distribution of the G-2964A and C734A genetic polymorphisms did not show significant difference between Chinese and Japanese populations. The incidence of C734A in Chinese was also similar to that in Caucasian population.
Han
X M
XM
Pharmacogenetics Research Institute, Basic and Clinical Pharmacology Institute, Hunan Medical University, Changsha 410078, China.
Chen
X P
XP
Wu
Q N
QN
Jiang
C H
CH
Zhou
H H
HH
D000328:Adult; D000483:Alleles; D044466:Asian People; D002681:China; D019388:Cytochrome P-450 CYP1A2 / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007564:Japan; D008875:Middle Aged; D017354:Point Mutation; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D044465:White People
D019388:Cytochrome P-450 CYP1A2