[Long-term correction of brain function. Prospects of immunologic approaches].
Among various approaches to long-term correction of the highest functions of the brain there are two methods that are particularly promising. These included: 1) induction of autoantibodies against the enzymes involved in the metabolism of neuroregulators by means of immunization of respective heterologous enzymes; 2) immunization by covalent conjugates of monomolecular neurotropic compounds and neuropeptides with antigen carriers. The investigations of both methods are reviewed and illustrated in experiments on albino rats during alcoholization and some other processes of pathological behavior formation. Evidence is provided for that behavior can be corrected for several months or longer.
Ashmarin
I P
IP
Danilova
R A
RA
Obuchova
M F
MF
D000437:Alcoholism / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000502:physiology*; D005260:Female; D013006:Growth Hormone / Q000276:immunology / Q000627:therapeutic use; D006613:Higher Nervous Activity; D006801:Humans; D007114:Immunization; D009842:Oligopeptides / Q000276:immunology / Q000627:therapeutic use; D051381:Rats; D019966:Substance-Related Disorders / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors; D001615:beta-Endorphin / Q000276:immunology / Q000627:therapeutic use
D009842:Oligopeptides; C010212:litorin; D001615:beta-Endorphin; D013006:Growth Hormone