Mouse Sox8 is located between, not within,the t-complex deletions t(w18) and t(h20) on chromosome 17.
The SOX family of developmental transcription factors is known to play critical roles in cell lineage specification, fate determination and differentiation during development in diverse phyla. Their importance is underscored by their involvement in a number of human diseases and mouse mutants, and by targeted mutation in mice. SOX8 is broadly expressed during development and is located on human chromosome 16p and within the t-complex on mouse chromosome 17, in the vicinity of two mutations t(w18) and t(h20). Here we analyse mutant genomic DNA to show that the Sox8 gene locus lies outside the deletion regions of both t(w18) and t(h20) and between these deletions. These data exclude Sox8 from contributing to the t(w18) and t(h20) phenotypes, and provide an additional marker for structural characterization of this complex genomic region.
Schepers
G
G
Centre for Molecular and Cellular Biology, Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia.
Koopman
D000818:Animals; D002872:Chromosome Deletion; D017931:DNA Primers / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics*; D023061:Gene Order / Q000235:genetics; D005838:Genotype; D051379:Mice; D009154:Mutation / Q000235:genetics*; D020161:Physical Chromosome Mapping; D055757:SOXE Transcription Factors; D014157:Transcription Factors / Q000235:genetics*
D017931:DNA Primers; D004268:DNA-Binding Proteins; D055757:SOXE Transcription Factors; C498639:Sox8 protein, mouse; D014157:Transcription Factors