The influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental transfer of antibodies and IgG subclasses in a rural West African population.
Two hundred thirteen mother-baby pairs in The Gambia were studied to determine the influence of placental malaria infection and maternal hypergammaglobulinemia on transplacental antibody transfer. Antibody transfer for herpes simplex virus 1 (HSV-1), respiratory syncytial virus (RSV), and varicella-zoster virus (VZV) was significantly reduced by placental malaria infection by 69%, 58%, and 55%, respectively. Maternal hypergammaglobulinemia was associated with a significant reduction in antibody transfer for HSV-1, RSV, VZV, and pneumococcus by 89%, 90%, 91%, and 88%, respectively. In addition, placental malaria infection was associated with a significant reduction in transfer of IgG1, IgG2, and IgG4 (P<.01, P=.01, and P=.03, respectively) but not of IgG3 (P=.59). Maternal hypergammaglobulinemia significantly impaired the transfer of IgG1 and IgG2 (P=.01) but not of IgG3 or IgG4 (P=.62 and P=.59, respectively). Placental malaria infection and maternal hypergammaglobulinemia were associated with reduction in the transplacental transfer of these specific antibodies, IgG1, and IgG2 in this Gambian population.
Okoko
B J
BJ
Vaccine Trial Unit, Medical Research Council, Fajara, Banjul, The Gambia, West Africa. okokobrown@hotmail.com
Wesumperuma
L H
LH
Ota
M O
MO
Pinder
M
M
Banya
W
W
Gomez
S F
SF
McAdam
K P
KP
Hart
A C
AC
D000328:Adult; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D000914:Antibodies, Viral / Q000097:blood / Q000276:immunology*; D005260:Female; D005714:Gambia; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007112:Immunity, Maternally-Acquired / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D007231:Infant, Newborn; D016778:Malaria, Falciparum / Q000276:immunology*; D008297:Male; D010920:Placenta / Q000276:immunology / Q000469:parasitology; D010922:Placenta Diseases / Q000276:immunology*; D010963:Plasmodium falciparum / Q000302:isolation & purification; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000276:immunology*
D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D007074:Immunoglobulin G