[Experimental study on preventive effect of traditional Chinese medicine replenishing recipe on acute oxygen toxicity caused by hyperbaric oxygen].
OBJECTIVE
To seek for the effective traditional Chinese medicine (TCM) replenishing recipe (RR) prescription that being able to prevent the onset of oxygen convulsion and to offer some clues in preventing the oxygen convulsion with TCM-RR.


METHODS
Mice were administered orally with four respective representative RR, Sijunzi Decoction, Siwu Decoction, Liuwei Dihuang Decoction, and Renshen Dihuang Decoction. Then the convulsion latent periods were recorded and SOD vitalities in brain and lung were determined.


RESULTS
Compared with the control groups, the convulsion latent period of Sijunzi Decoction group was prolonged significantly (P < 0.01) and its SOD vitality in lung was maintained higher (P < 0.01) after convulsion, while the other three RR results have no significant difference (P < 0.05).


CONCLUSIONS
Sijunzi Decoction has certain preventive effect on acute oxygen convulsion.
Li
R
R
Department of Pharmacognosy, College of Pharmacology, Second Military Medical University, Shanghai 200433.
Qin
L
L
Wang
Y
Y
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008297:Male; D051379:Mice; D010100:Oxygen / Q000506:poisoning*; D011897:Random Allocation; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D000927:Anticonvulsants; D004365:Drugs, Chinese Herbal; D010100:Oxygen