Kainic acid induces selective mitochondrial oxidative phosphorylation enzyme dysfunction in cerebellar granule neurons: protective effects of melatonin and GSH ethyl ester.
Dabbeni-Sala
F
F
Department of Pharmacology, University of Padova, 35131 Padova, Italy.
Floreani
M
M
Franceschini
D
D
Skaper
S D
SD
Giusti
P
P
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002531:Cerebellum / Q000166:cytology; D042963:Electron Transport Complex II; D005978:Glutathione / Q000031:analogs & derivatives / Q000494:pharmacology*; D007608:Kainic Acid / Q000494:pharmacology*; D008550:Melatonin / Q000494:pharmacology*; D008928:Mitochondria / Q000201:enzymology*; D009097:Multienzyme Complexes / Q000378:metabolism; D009474:Neurons / Q000648:ultrastructure*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D017382:Reactive Oxygen Species / Q000378:metabolism; D013385:Succinate Dehydrogenase / Q000378:metabolism
D000975:Antioxidants; D009097:Multienzyme Complexes; D017382:Reactive Oxygen Species; C042431:S-ethyl glutathione; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; D005978:Glutathione; D008550:Melatonin; D007608:Kainic Acid