title: Identification of metastasis-associated genes by transcriptional profiling of a metastasizing versus a non-metastasizing human melanoma cell line.
abstract: In order to identify genes associated with the metastatic phenotype we have compared the expression pattern of 6800 genes in a metastatic (NMCL-1) versus a non-metastatic (530) human melanoma cell line making use of DNA microarrays. The differentially expressed genes identified are involved in control of transcription, regulation of the cell-cycle, proteolysis, cell adhesion, immune response and signaling. A remarkable feature of the system under investigation is the consistent down-regulation of MHC-related and cell adhesion mediating genes in the metastatic cell line.
authors.affiliation: Roche Pharma Research, Basel, Switzerland.
authors.forename: R
authors.initials: R
authors.lastname: Brem
authors.forename: T
authors.initials: T
authors.lastname: Hildebrandt
authors.forename: M
authors.initials: M
authors.lastname: Jarsch
authors.forename: G N
authors.initials: GN
authors.lastname: Van Muijen
authors.forename: U H
authors.initials: UH
authors.lastname: Weidle
mesh_terms: D000818:Animals; D015152:Blotting, Northern; D015536:Down-Regulation; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D008545:Melanoma / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D020411:Oligonucleotide Array Sequence Analysis; D010641:Phenotype; D012333:RNA, Messenger / Q000378:metabolism; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured; D015854:Up-Regulation
chemical_list: D012333:RNA, Messenger