Failure of the ubiquitin-proteasome system in Parkinson's disease.
McNaught
K S
KS
Neuroregeneration Laboratory, Harvard Medical School and McLean Hospital, 115 Mill Street, Belmont, MA 02478, USA. kevin.mcnaught@mclean.harvard.edu
Olanow
C W
CW
Halliwell
B
B
Isacson
O
O
Jenner
P
P
D000818:Animals; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D016631:Lewy Bodies / Q000235:genetics / Q000378:metabolism / Q000473:pathology; D009097:Multienzyme Complexes / Q000235:genetics / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000235:genetics / Q000378:metabolism; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D010447:Peptide Hydrolases / Q000235:genetics / Q000378:metabolism; D046988:Proteasome Endopeptidase Complex; D013378:Substantia Nigra / Q000378:metabolism* / Q000473:pathology / Q000503:physiopathology; D014452:Ubiquitins / Q000235:genetics / Q000378:metabolism*
D009097:Multienzyme Complexes; D009419:Nerve Tissue Proteins; D014452:Ubiquitins; D010447:Peptide Hydrolases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex