title: Extreme hypergastrinemia caused by atrophic gastritis and Helicobacter pylori infection--a case report.
abstract: We present a case with extremely high serum gastrin induced by atrophic gastritis and Helicobacter pylori infection. The patient, a 95-year-old male, was diagnosed with idiopathic chronic diarrhea. During diagnostic work-up, his fasting serum gastrin was up to 2078 pg/mL. The secretin test was negative for gastrinoma. Octreotide scan showed no suspicious lesion except for diffuse faint uptake over the gastric antrum on the 48-hour-delay film. Gastric acidity test revealed achlorhydria. On histology examination, atrophic gastritis with Helicobacter pylori infection was found in the gastric body, but the antral mucus was normal with a slight increase in gastrin-secreting cells. To our knowledge, such extremely high serum gastrin induced by atrophic gastritis and Helicobacter pylori infection has never been reported before.
authors.affiliation: Department of Surgery, Buddhist Tzu Chi General Hospital and Tzu Chi College of Medicine and Humanities, 707, Chung Yan Rd., Sec. 3, Hualien, Taiwan. HS-Ming@hcc.tcu.edu.tw
authors.forename: S M
authors.initials: SM
authors.lastname: Huang
authors.forename: H H
authors.initials: HH
authors.lastname: Lin
authors.forename: T Y
authors.initials: TY
authors.lastname: Wen
authors.forename: Y H
authors.initials: YH
authors.lastname: Hsu
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001284:Atrophy; D005755:Gastrins / Q000097:blood*; D005756:Gastritis / Q000097:blood* / Q000473:pathology; D016481:Helicobacter Infections / Q000150:complications*; D016480:Helicobacter pylori; D006801:Humans; D007150:Immunohistochemistry; D008297:Male
chemical_list: D005755:Gastrins