Significance of distribution volume in dialysis quantification.
The urea distribution volume is in several ways an important parameter in the treatment of end-stage renal disease (ESRD) patients. It has a major impact on the relative dose of dialysis treatment as measured by Kt/V. It is also important in the assessment of fluid status, which has a direct influence on blood pressure. Nevertheless, urea distribution volume is usually not measured on a regular basis, probably because it has been perceived as a relatively complicated measurement. With the arrival of on-line monitors for dialysate urea this situation has improved radically. In this article a number of volume determination methods are discussed, including some new methods based on on-line dialysate urea monitoring, which are shown to perform well in comparison to reference methods.
Sternby
J
J
Gambro Lundia AB, S-220 10 Lund, Sweden. jan.sternby@gambro.com
D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000628:therapy*; D006435:Renal Dialysis; D014508:Urea / Q000097:blood*
D014508:Urea