Results of intra-operative 0.5mg/ml mitomycin C with 20mg depo steroid in the treatment of primary pterygium.
OBJECTIVE
The effectiveness of intra-operative mitomycin C on the recurrence rate of pterygium in patients undergoing primary pterygium excision was assessed.


METHODS
51 consecutive primary pterygia of 46 patients were excised between April and December 1998. 0.5 mg/ml mitomycin C was applied on bare sclera for one minute and 20 mg depot steroid injected subconjunctivally. Post operatively patients were placed on Gutt Dexamethasone 0.1% with antazoline and chloramphenicol 1.0%.


RESULTS
Follow up ranged from four to 14 months. There was no recurrence of pterygium. Side effects of treatment included: delayed wound healing, avascularised sclera and pyogenic granuloma.


CONCLUSIONS
This study suggests that intraoperative application of 0.5 mg/ml mitomyin C with 20 mg depot steroid following primary pterygium excision is effective and safe in preventing recurrence.
Mpyet
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C
Department of Ophthalmology, Jos University Teaching Hospital, PMB 2076, Jos, Nigeria.
Oko
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H
Mypet
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C
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D003692:Delayed-Action Preparations; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007267:Injections; D007430:Intraoperative Care / Q000379:methods*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000627:therapeutic use*; D019384:Nucleic Acid Synthesis Inhibitors / Q000627:therapeutic use*; D011625:Pterygium / Q000188:drug therapy* / Q000601:surgery*; D012008:Recurrence; D013256:Steroids; D016896:Treatment Outcome
D000893:Anti-Inflammatory Agents; D003692:Delayed-Action Preparations; D019384:Nucleic Acid Synthesis Inhibitors; D013256:Steroids; D016685:Mitomycin