Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease.
Purpose: To test the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid-lesioned rats. Methods: Rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed one week later. Results: NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. Conclusions: NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism.
Cruz-Aguado
Reyniel
R
Neurochemistry Laboratory, International Center for Neurological Restoration, Havana, Cuba.
Turner
Liliana Francis
LF
Díaz
Carmen M.
CM
Piñero
Janet
J