title: Anti-inflammatory and analgesic activity of Indian Hypericum perforatum L.
abstract: A standardised 50% aqueous ethanolic extract of the Indian variety of Hypericum perforatum (IHp) was examined for its putative anti-inflammatory and analgesic activity at the doses of 100 and 200 mg/kg, po. The experimental paradigms used were carrageenan induced pedal edema and cotton pellet induced granuloma for anti-inflammatory activity, whereas the tail flick, hot plate and acetic acid induced writhing methods were used to asses analgesic activity. Indomethacin (20 mg/kg, ip) was used as the standard anti-inflammatory drug. Pentazocine (10 mg/kg, ip) and aspirin (25 mg/kg, ip), both clinically used analgesics, were used as standard analgesics for comparison. IHp extract showed significant anti-inflammatory and analgesic activity at both dose levels, in all the paradigms used. Additionally, IHp potentiated the anti-inflammatory activity of indomethacin and analgesic activities of pentazocine and aspirin.
authors.affiliation: Department of Pharmaceutics, Banaras Hindu University, Varanasi, India.
authors.forename: V
authors.initials: V
authors.lastname: Kumar
authors.forename: P N
authors.initials: PN
authors.lastname: Singh
authors.forename: S K
authors.initials: SK
authors.lastname: Bhattacharya
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D004487:Edema / Q000188:drug therapy; D005260:Female; D015745:Granuloma, Foreign-Body / Q000188:drug therapy; D020902:Hypericum / Q000737:chemistry*; D008297:Male; D051379:Mice; D017288:Pain Threshold / Q000187:drug effects; D010423:Pentazocine / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D001241:Aspirin; D010423:Pentazocine