Serum lactate dehydrogenase isoenzyme 1 and relapse in patients with nonseminomatous testicular germ cell tumors clinical stage I.
Serum lactate dehydrogenase isoenzyme 1 catalytic concentration (S-LD-1) was measured at the time of orchiectomy in 104 patients with nonseminomatous testicular germ cell tumors (NSTGCT) clinical stage I who participated in a randomized study comparing surveillance after orchiectomy (group I) and radiotherapy (group II). For 68 patients, S-LD-1 was measured in a serum sample before or on the day of the orchiectomy. Twenty-seven patients (40%) had elevated S-LD-1; median 102 U/L (range 41-335). For the remaining 36 patients. S-LD-1 was measured in a serum sample after orchiectomy: 8 of these patients (22%) had elevated S-LD-1. S-LD-1 was normalized shortly after surgery in most patients with a preorchiectomy elevated S-LD-1. Fifteen of the 68 patients relapsed: 9 out of 27 with an elevated S-LD-1 and 6 out of 41 patients with normal S-LD-1 (p = 0.13, Fisher's exact test). In group 1, those with a preoperatively elevated S-LD-1 had a lower 8-years' relapse-free survival than those with a normal S-LD-1 (40% vs. 80%, p = 0.003, log-rank test). The role of S-LD-1 in the staging, prognostication and monitoring of patients with NSGCT clinical stage I should be further explored in a large, prospective study.
von Eyben
F E
FE
Department of Clinical Chemistry, Odense University Hospital, Denmark. feve@post5.tele.dk
Madsen
E L
EL
Blaabjerg
O
O
Petersen
P H
PH
von der Maase
H
H
Jacobsen
G K
GK
Rørth
M
M
D000293:Adolescent; D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D018236:Carcinoma, Embryonal / Q000201:enzymology* / Q000473:pathology; D003131:Combined Modality Therapy; D003718:Denmark / Q000453:epidemiology; D018572:Disease-Free Survival; D018240:Endodermal Sinus Tumor / Q000201:enzymology* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009362:Neoplasm Metastasis; D009363:Neoplasm Proteins / Q000097:blood*; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D009919:Orchiectomy; D018714:Radiotherapy, Adjuvant; D013724:Teratoma / Q000201:enzymology* / Q000473:pathology; D013736:Testicular Neoplasms / Q000201:enzymology* / Q000473:pathology; D016896:Treatment Outcome
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D009363:Neoplasm Proteins; D007770:L-Lactate Dehydrogenase