title: Do antibodies to pneumococcal surface adhesin a prevent pneumococcal involvement in acute otitis media?
abstract: Antibodies to the pneumococcal (Pnc) surface protein PsaA are immunogenic and protective in experimental animal models, but their role in protection from Pnc disease in humans is not known. In the present study, the ability of antibodies to PsaA to prevent the progression of Pnc carriage to Pnc acute otitis media (Pnc AOM) was evaluated. Antibodies to PsaA were measured in acute-phase serum samples of children with AOM and with Streptococcus pneumoniae cultured from the nasopharynx. The risk of Pnc AOM was evaluated by a logistic regression model with anti-PsaA concentration as the predictive variable. Higher concentrations of antibodies to PsaA were associated with lower risk of the Pnc nasopharyngeal carriage progression to Pnc AOM. This was true in children 9-24 months old (odds ratio [OR], 0.49; 95% confidence interval [CI], 0.31-0.78) but not in children <9 months old (OR, 0.81; 95% CI, 0.48-1.35).
authors.affiliation: National Public Health Institute, Department of Vaccines, 00300 Helsinki, Finland. satu.rapola@ktl.fi
authors.forename: S
authors.initials: S
authors.lastname: Rapola
authors.forename: T
authors.initials: T
authors.lastname: Kilpi
authors.forename: M
authors.initials: M
authors.lastname: Lahdenkari
authors.forename: A K
authors.initials: AK
authors.lastname: Takala
authors.forename: P H
authors.initials: PH
authors.lastname: Mäkelä
authors.forename: H
authors.initials: H
authors.lastname: Käyhty
mesh_terms: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial / Q000097:blood / Q000276:immunology*; D001426:Bacterial Proteins; D002352:Carrier Proteins / Q000276:immunology*; D002353:Carrier State / Q000382:microbiology; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008074:Lipoproteins / Q000276:immunology*; D026901:Membrane Transport Proteins; D009305:Nasopharynx / Q000382:microbiology; D010034:Otitis Media with Effusion / Q000276:immunology / Q000382:microbiology* / Q000517:prevention & control*; D011008:Pneumococcal Infections / Q000276:immunology / Q000382:microbiology / Q000517:prevention & control; D013296:Streptococcus pneumoniae / Q000276:immunology* / Q000378:metabolism
chemical_list: D018829:Adhesins, Bacterial; D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D002352:Carrier Proteins; D008074:Lipoproteins; D026901:Membrane Transport Proteins; C085000:PsaA protein, Streptococcus