title: [Characteristic perfusion pattern of osseous giant cell tumor in dynamic contrast-enhanced MRI].
abstract: OBJECTIVE
  To describe the perfusion pattern of giant cell tumor (GCT) of bone with Gd-enhanced dynamic MR imaging. To compare time-intensity-curves in patients with local recurrence and postoperative alterations without recurrence.
  
  
  METHODS
  Nine patients (5 women, 4 men) with GCT of bone underwent 19 dynamic MRI examinations. Mean age was 34 years (range 24-64 years). All diagnoses were proven by pathology. Dynamic contrast-enhanced MRI was performed at 1.0 T using T1-weighted gradient echo sequences. GCT was located in the distal radius (4x), tibia (3x), fibula (1x) and humeral head (1x).
  
  
  RESULTS
  All giant cell tumors showed a uniform perfusion pattern with a steep slope and maximum intensity value followed by an early and rapid washout phase. The same pattern appeared in five local recurrences of GCT in four patients. In nine follow-up examinations without local recurrence dynamic MRI yielded in uncharacteristic perfusion patterns.
  
  
  CONCLUSIONS
  These results demonstrate a uniform perfusion pattern of GCT of bone obtained by dynamic MRI. It is characterized by a steep slope followed by an early and rapid washout phase. This characteristic pattern can also be obtained in local recurrences. Dynamic contrast-enhanced MRI appears a helpful method for primary diagnosis of GCT of bone and detection of local recurrences after surgery.
authors.affiliation: Abteilung Radiodiagnostik, Universitätsklinikum Heidelberg. martin.libicher@urz.uni-heidelberg.de
authors.forename: M
authors.initials: M
authors.lastname: Libicher
authors.forename: L
authors.initials: L
authors.lastname: Bernd
authors.forename: J P
authors.initials: JP
authors.lastname: Schenk
authors.forename: U
authors.initials: U
authors.lastname: Mädler
authors.forename: L
authors.initials: L
authors.lastname: Grenacher
authors.forename: G W
authors.initials: GW
authors.lastname: Kauffmann
mesh_terms: D000328:Adult; D001783:Blood Flow Velocity / Q000502:physiology; D001859:Bone Neoplasms / Q000098:blood supply* / Q000175:diagnosis / Q000473:pathology; D001842:Bone and Bones / Q000098:blood supply / Q000473:pathology; D003287:Contrast Media; D005260:Female; D019786:Gadolinium DTPA; D018212:Giant Cell Tumor of Bone / Q000098:blood supply* / Q000175:diagnosis / Q000473:pathology; D006801:Humans; D007089:Image Enhancement; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000098:blood supply / Q000175:diagnosis / Q000473:pathology; D011446:Prospective Studies; D012039:Regional Blood Flow / Q000502:physiology
chemical_list: D003287:Contrast Media; D019786:Gadolinium DTPA