[Rapid effects of hydrocortisone on the cholinergic synaptic transmission of B neurons in bullfrog sympathetic ganglia].
Rapid effects of hydrocortisone 21-hemisuccinate (F-suc) on cholinergic synaptic transmission of B neurons in bullfrog sympathetic ganglia (BFSG) were studied with intracellular recording technique in vitro. The main results are as follows: (1) F-suc blocked cholinergic synaptic transmission of 52 B neurons within 0.5-3 min, which was concentration-dependent and partially suppressed by the cytoplasm receptor antagonist of steroid hormones, RU38486; (2) after protein synthesis was suppressed by actidione, the above effect persisted; and (3) the effect of F-suc could be potentiated by atropine. All these results suggest that the F-suc induced rapid effects of cholinergic synaptic transmission of B neurons in BFSG may be mediated by non-genomic mechanisms.
Yi
B D
BD
Department of Physiology, Second Military Medical University, Shanghai 200433.
Ma
B
B
Xing
B R
BR
D000818:Animals; D005260:Female; D005728:Ganglia, Sympathetic / Q000502:physiology*; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects; D011892:Rana catesbeiana; D011950:Receptors, Cholinergic / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects* / Q000502:physiology
D011950:Receptors, Cholinergic; C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone