[The state of the pulmonary surfactant system in patients with the acute pulmonary damage syndrome].
There were examined the surface-active properties and phospholipidious contents of the breathed out air condensate and the general respiratory compliance (C) in 21 patients with an acute pulmonary damage syndrome (APDS), caused by pancreonecrosis, peritonitis, polytrauma, sepsis. The lowering of the surface activity, reducing of phosphatidylcholine content and raising of phosphatidylethanolamine level, significant C lowering were noted. Such changes were more pronounced in patients, which have died subsequently. This testifies the profound inhibition of the pulmonary surfactant system activity in patients with APDS. It is expedient to apply the exogenic surfactant preparations for the treatment of patients with APDS.
Potapov
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D000208:Acute Disease; D002855:Chromatography, Thin Layer / Q000379:methods; D006801:Humans; D008171:Lung Diseases / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D010713:Phosphatidylcholines / Q000378:metabolism; D011663:Pulmonary Surfactants / Q000378:metabolism* / Q000627:therapeutic use*
D010713:Phosphatidylcholines; D011663:Pulmonary Surfactants