Potential of block copolymer- and immuno-conjugates for tumor-targeted delivery of Bowman-Birk soybean proteinase inhibitor.
The present work reports the effect of conjugation of the anticarcinogenic and antitumor soybean Bowman-Birk protease inhibitor (BBI) with amphiphilic block copolymer of ethylene oxide and propylene oxide (PEO-PPO) as well as with monoclonal antibody via clinical dextran (D) on tumor-targeted delivery of BBI.
Gladysheva
I P
IP
Lomonosov Moscow State University, 119899, Moscow, Russia. gladysheva@enzyme.chem.msu.ru
Polekhina
O V
OV
Karmakova
T A
TA
Nemtsova
E R
ER
Yakubovskaya
R I
RI
Shen
W C
WC
Kennedy
A R
AR
Larionova
N I
NI
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology*; D018938:Caco-2 Cells; D003911:Dextrans; D004337:Drug Carriers; D016503:Drug Delivery Systems; D004852:Epoxy Compounds; D005027:Ethylene Oxide; D005455:Fluorescent Antibody Technique; D006801:Humans; D018796:Immunoconjugates / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology*; D007150:Immunohistochemistry; D051379:Mice; D011108:Polymers; D014018:Tissue Distribution; D014358:Trypsin Inhibitor, Bowman-Birk Soybean / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology*
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents; D003911:Dextrans; D004337:Drug Carriers; D004852:Epoxy Compounds; D018796:Immunoconjugates; D011108:Polymers; D014358:Trypsin Inhibitor, Bowman-Birk Soybean; D005027:Ethylene Oxide; C009068:propylene oxide