Prevalence of vaginal colonization by drug-resistant Candida species in college-age women with previous exposure to over-the-counter azole antifungals.
We enrolled 382 college-age women in a cross-sectional survey to investigate the relationship between use of over-the-counter (OTC) azole-based antifungal drugs and vaginal colonization by drug-resistant Candida. This study showed no correlation (P=.506) between previous OTC exposure and colonization of drug-resistant Candida in vaginal flora. However, a small number of resistant Candida species isolates were obtained from women with a history of multiple exposures to OTC antifungals; given the widespread use of these products, this may be an emerging concern.
Mathema
B
B
Public Health Research Institute, New York, NY, USA.
Cross
E
E
Dun
E
E
Park
S
S
Bedell
J
J
Slade
B
B
Williams
M
M
Riley
L
L
Chaturvedi
V
V
Perlin
D S
DS
D000328:Adult; D000935:Antifungal Agents / Q000627:therapeutic use*; D001393:Azoles / Q000627:therapeutic use*; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy* / Q000453:epidemiology*; D003430:Cross-Sectional Studies; D004352:Drug Resistance, Microbial; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D004366:Nonprescription Drugs / Q000627:therapeutic use; D015995:Prevalence; D013334:Students / Q000706:statistics & numerical data*; D014481:United States / Q000453:epidemiology
D000935:Antifungal Agents; D001393:Azoles; D004366:Nonprescription Drugs; D015725:Fluconazole