title: Cytotoxic activity of moronic acid and identification of the new triterpene 3,4-seco-olean-18-ene-3,28-dioic acid from Phoradendron reichenbachianum.
abstract: The cytotoxic compound moronic acid (1) and the new tetracyclic triterpene 3,4-seco-olean-18-ene-3,28-dioic acid (2), were isolated from the aerial parts of the medicinal plant Phoradendron reichenbachianum (mistletoe, Loranthaceae) through a bioassay-guided fractionation. In addition, squalene, glycerol trilinoleate, morolic acid, betulonaldehyde, betulinaldehyde, alpha-germanicol, lupeol, beta-sitosterol and beta-sitosteril glucopyranoside, were identified in this plant species. The structures were elucidated on the basis of chemical and spectroscopic evidence.
authors.affiliation: Centro de Investigaciones Químicas de la Universidad Autónoma del Estado de Morelos, Cuernavaca, Mexico. yrios@iqunam.iquimica.unam.mx
authors.forename: M Y
authors.initials: MY
authors.lastname: Rios
authors.forename: D
authors.initials: D
authors.lastname: Salina
authors.forename: M L
authors.initials: ML
authors.lastname: Villarreal
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002460:Cell Line; D009682:Magnetic Resonance Spectroscopy; D019684:Magnoliopsida / Q000737:chemistry*; D015394:Molecular Structure; D009828:Oleanolic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology*; D018547:Plant Stems; D010946:Plants, Medicinal; D014315:Triterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: C438024:3,4-seco-olean-18-ene-3,28-dioic acid; D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes; C023607:moronic acid; D009828:Oleanolic Acid