title: Helical antenna arrays for interstitial microwave thermal therapy for prostate cancer: tissue phantom testing and simulations for treatment.
abstract: Interstitial microwave therapy is an experimental treatment for prostate cancer. The objective of this work was to measure the power deposition (specific absorption rate, SAR) patterns of helical microwave antennae both individually and in array patterns that would be useful for clinical treatment protocols. Commercial helical antenna 3D SAR patterns were measured in muscle equivalent phantoms using a thermographic technique. Two array patterns were tested: a 'square' and a 'crescent' array, both surrounding the urethra. To assess the feasibility of pre-treatment planning, the measured SAR patterns were input to a treatment planning computer simulation program based on a series of trans-rectal ultrasound images from a prostate cancer patient. The simulation solved the Pennes linear bioheat heat transfer equation in prostate tissue, with the aim of achieving a target of 55 degrees C at the prostate periphery while not allowing normal surrounding tissues (bladder, urethra, rectum) to rise above 42 C. These criteria could not be met with the square array but they could be met with the crescent array, provided that the prostate was first dissected away from the rectum. This can be done with a procedure such as 'hydrodissection', where sterile saline is injected to separate the prostate and rectum. The results of these SAR measurements and heat transfer simulations indicate that arrays of helical antennae could be used for safe and effective thermal therapy for prostate cancer.
authors.affiliation: Ontario Cancer Institute/Princess Margaret Hospital, University Health Network, Toronto, Canada.
authors.forename: M D
authors.initials: MD
authors.lastname: Shera
authors.forename: A S
authors.initials: AS
authors.lastname: Gladman
authors.forename: S R
authors.initials: SR
authors.lastname: Davidson
authors.forename: J
authors.initials: J
authors.lastname: Trachtenberg
authors.forename: M R
authors.initials: MR
authors.lastname: Gertner
mesh_terms: D000180:Acrylic Resins / Q000737:chemistry; D006801:Humans; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008962:Models, Theoretical; D019047:Phantoms, Imaging; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D013696:Temperature; D014465:Ultrasonics; D014463:Ultrasonography; D000099166:Polyacrylamides
chemical_list: D000180:Acrylic Resins; D000099166:Polyacrylamides