New steroid glycosides from the starfish Asterias rathbuni.
Two novel steroidal 24-O-xylosides, designated as rathbuniosides R(1) (1) and R(2) (2), and the known amurensoside A (3) and 3-O-sulfomarthasterone (4) have been isolated from the starfish Asterias rathbuni. The structures of all the compounds were determined from their spectroscopic data, including one- and two-dimensional NMR methods. The compounds 1 and 4 inhibit the cell division of fertilized sea urchin eggs at doses of 7.0 x 10(-5) and 2.9 x 10(-5) M, respectively.
Ivanchina
N V
NV
Pacific Institute of Bioorganic Chemistry of the Far East Branch of the Russian Academy of Science, Vladivostok-22, Russian Federation.
Kicha
A A
AA
Kalinovsky
A I
AI
Dmitrenok
P S
PS
Prokofreva
N G
NG
Stonik
V A
VA
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D005260:Female; D006027:Glycosides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins / Q000494:pharmacology*; D015394:Molecular Structure; D010063:Ovum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D012617:Sea Urchins; D019032:Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; D013215:Starfish / Q000737:chemistry*; D013256:Steroids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
C435867:3-O-sulfomarthasterone; D006027:Glycosides; D008387:Marine Toxins; D013256:Steroids; C435866:amurensoside A; C435864:rathbunioside R1; C435865:rathbunioside R2