A comparative study of induction and recovery characteristics of propofol and midazolam.
Propofol and midazolam were compared in 40 adult patients in A.S.A. 1 or 2 presenting for short surgical procedures (< 70 minutes) with respect to induction time, pain on injection, apnoea, heart rates, blood pressure, oxygen saturation, time to eye opening on command. The first group was induced with midazolam (0.15-0.20 mg/kg) while the second was induced with propofol (2-2.5 mg/kg) intravenously. In all other respects except for the surgery that patients had the same treatment. The mean induction time was 55.25 + 26.66 and 69.75 + 24.72 for propofol and midazolam groups respectively. In the midazolam group apnoea occurred in 10% of patients compared to 80% of patients in the propofol group. Local reaction (phlebitis) was absent in the midazolam compared with 20% incident rate observed in the midazolam group. Propofol lowered blood pressure more than midazolam after three minutes of induction at a statistically significant level (P < 0.05). Recovery was significantly more rapid following propofol (P < 0.05).
Edomwonyi
N P
NP
Department of Anaesthesia, University of Benin Teaching Hospital, Benin City, Edo State.
Okonofua
B A
BA
Weerasinghe
A S
AS
Dangnan
F
F
D000293:Adolescent; D000368:Aged; D000762:Anesthesia Recovery Period; D018686:Anesthetics, Intravenous / Q000009:adverse effects / Q000494:pharmacology*; D001049:Apnea / Q000139:chemically induced; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008874:Midazolam / Q000009:adverse effects / Q000494:pharmacology*; D008875:Middle Aged; D009549:Nigeria; D010146:Pain / Q000209:etiology; D015742:Propofol / Q000009:adverse effects / Q000494:pharmacology*; D013997:Time Factors
D018686:Anesthetics, Intravenous; D008874:Midazolam; D015742:Propofol