The modulatory effect of estrogen on the neuronal activity in the barrel cortex of the rat. An electrophysiological study.
In acute experiments, the effects of iontophoretically applied 17 beta-estradiol hemisuccinate on the activity of the primary somatosensory cortical neurons were studied in ovariectomized rats by extracellular single-unit recording. 17 beta-Estradiol increased both the spontaneous and the vibrissa deflection-evoked responses, with an average latency of 24 min. It is suggested that this relatively long latency of the 17 beta-estradiol effect is based not so much on membrane mechanisms as on genomic mechanisms.
Kis
Z
Z
Department of Comparative Physiology, University of Szeged, H-6701 Szeged, POB 533, Hungary.
Budai
D
D
Imre
G
G
Farkas
T
T
Horváth
S
S
Toldi
J
J
D000818:Animals; D004594:Electrophysiology; D004958:Estradiol / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D005260:Female; D018698:Glutamic Acid / Q000494:pharmacology; D007478:Iontophoresis; D009473:Neuronal Plasticity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000166:cytology* / Q000502:physiology; D014738:Vibrissae / Q000294:innervation; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D018698:Glutamic Acid; D004958:Estradiol; D005680:gamma-Aminobutyric Acid