title: [Differentiated approach to preventive treatment of new cases of tuberculosis in children].
abstract: The efficiency of various preventive treatment regimens was studied in 330 new cases of childhood tuberculosis by using clinical and laboratory findings and follow-up data. The paper shows it expedient to conduct a comprehensive immunological studies by tuberculin diagnosis and to examine immunity both at the time of infection detection in children and at their follow-ups. Monotherapy by the routine regimen can be performed in low tuberculin-sensitive children without risk factors. Children who have a complex of risk factors need long-term preventive treatment with two tuberculosis controlling agents. When immune responsiveness declines in children, it is necessary to apply pathogenetic agents that possess an immunomodulating effect, which substantially raise the efficiency of preventive treatment.
authors.forename: L I
authors.initials: LI
authors.lastname: Mordovskaia
authors.forename: V A
authors.initials: VA
authors.lastname: Aksenova
authors.forename: S S
authors.initials: SS
authors.lastname: Gavril'ev
authors.forename: A P
authors.initials: AP
authors.lastname: Ivanova
mesh_terms: D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000293:Adolescent; D000367:Age Factors; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D012307:Risk Factors; D012737:Sex Factors; D013997:Time Factors; D014374:Tuberculin Test; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology / Q000517:prevention & control*
chemical_list: D000276:Adjuvants, Immunologic; D000995:Antitubercular Agents