title: Effect of histamine H3-receptor antagonist clobenpropit on spatial memory of radial maze performance in rats.
abstract: OBJECTIVE
  The effect of histamine H3-receptor antagonist, clobenpropit (VUF9153) on spatial memory deficits induced by scopolamine was investigated in rats.
  
  
  METHODS
  Eight-Arm radial maze performance was used to measure spatial memory in rats, and the brain regions were subsequently dissected and histamine contents were determined by HPLC.
  
  
  RESULTS
  Intracerebroventricular (icv) injection of clobenpropit (50 micrograms) ameliorated memory impairment induced by scopolamine in both parameters of radial maze performance. The amelioration induced by clobenpropit was antagonized by an H3-agonist, (R)-alpha-methylhistamine (5-10 micrograms). alpha-Fluoromethylhistidine (10, 20 micrograms), a histidine decarboxylase inhibitor, also effectively reversed clobenpropit-induced ameliorating effects.
  
  
  CONCLUSIONS
  The brain histamine H3-receptor antagonists are highly related to the spatial memory, and this action may be due to cholinergic neurons.
authors.affiliation: Department of Pharmacology, School of Medicine, Zhejiang University, Hangzhou 310031, China. chenzfl@hotmail.com
authors.forename: Z
authors.initials: Z
authors.lastname: Chen
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D006633:Histamine Antagonists / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008569:Memory Disorders / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine; D013890:Thiourea / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D006633:Histamine Antagonists; D007093:Imidazoles; D006632:Histamine; D012601:Scopolamine; D013890:Thiourea; C086108:clobenpropit