title: Brain dysfunction explored by long latency reflex: a study of adrenomyeloneuropathy.
abstract: OBJECTIVE
  We can assess brain function by measuring the cortical relay time (CRT) of long latency reflex (LLR) of hand muscle. We would study if measurement of CRT of LLR can explore the brain involvement of adrenomyeloneuropathy (AMN).
  
  
  METHODS
  Two AMN patients were included in the study. Both of them had spastic gait and mild sensory deficits but normal mental function. The LLRs were provoked at the first dorsal interosseous muscle by electrical stimulation of the middle finger. We measured the latency of LLR and its CRT.
  
  
  RESULTS
  Delayed LLR and prolonged CRT were noted in AMN patients, even though the magnetic resonance imaging of brain did not show any significant abnormalities.
  
  
  CONCLUSIONS
  Measuring CRT of LLR reveals brain involvement of AMN patients, and it is an adjunct in the assessment of brain function though without specific anatomic diagnosis.
authors.affiliation: Neurology, Neurological Institute, Taipei Veterans General Hospital, Taiwan. kkliao@vghtpe.gov.tw
authors.forename: K K
authors.initials: KK
authors.lastname: Liao
authors.forename: J T
authors.initials: JT
authors.lastname: Chen
authors.forename: K P
authors.initials: KP
authors.lastname: Lin
authors.forename: C C
authors.initials: CC
authors.lastname: Chen
authors.forename: K P
authors.initials: KP
authors.lastname: Kao
authors.forename: Z A
authors.initials: ZA
authors.lastname: Wu
mesh_terms: D000326:Adrenoleukodystrophy / Q000473:pathology / Q000503:physiopathology*; D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D004558:Electric Stimulation; D019054:Evoked Potentials, Motor / Q000502:physiology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005385:Fingers / Q000503:physiopathology; D006801:Humans; D008297:Male; D018482:Muscle, Skeletal / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology*; D012021:Reflex, Abnormal / Q000502:physiology*