[Effects of nitric oxide on platelet function in burned rats].
OBJECTIVE
To investigate the effects of nitric oxide (NO) on rat platelet function after burn injury.


METHODS
Wistar rats with 30% TBSA full thickness burns were used as model, indices of platelet functions including platelet aggregation rate in first minute (PAR-1), maximal platelet aggregation rate (PAR-m), platelet dissipation rate (PDR) and platelet adhesion rate (PAR) were determined in four groups, namely burn control (B), NO donor (sin-1), NO synthesis inhibitor (L-NAME) and the normal control (C).


RESULTS
The PAR-1, PAR-m and PAR were significantly increased and the PDR was decreased remarkably after burn injury. In sin-1 group the PAR-1, PAR-m and PAR were obviously lower and the PDR was higher than that of B group (P < 0.05-0.01). In L-NAME group the PAR-1 was higher and the PDR was lower as compared with B group, but the PAR-m and PAR showed no significant differences between two groups.


CONCLUSIONS
The ability of platelet adhesion and aggregation induced by activated platelet are increased after burn injury. NO can partially reduce the degree of platelet activation and inhibit platelet aggregation. Moreover, it may dissipate aggregated platelets.
Peng
X
X
Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongquing, 400038.
Feng
J
J
Wang
S
S
D000818:Animals; D002056:Burns / Q000097:blood*; D005260:Female; D008297:Male; D008981:Molsidomine / Q000031:analogs & derivatives / Q000494:pharmacology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009569:Nitric Oxide / Q000502:physiology*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D020030:Nitric Oxide Donors; D010975:Platelet Aggregation Inhibitors; D009569:Nitric Oxide; C002385:linsidomine; D008981:Molsidomine; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester