[Inhibitory effect of electroacupuncture on the cardiovascular response evoked by applying bradykinin on the gallbladder].
The effects of electroacupuncture (EA) on the pressor response and reversible myocardial dysfunction induced by application of bradykinin (BK) on the gallbladder were studied in cats anesthetized with alpha-chloralose. The cardiovascular responses evoked by application of BK included a pressor response, an increase of LVP and its dP/dtmax, tachycardia and a decrease of local wall motion of the left ventricle with a supplying branch of the left anterior descending coronary artery ligated beforehand. Following EA of bilateral Neiguan acupionts, the pressor response of BK was inhibited, while the regional left ventricle myocardial dysfunction was alleviated significantly. The effects of EA were reversed by i.v. injection of naloxone (0.4 mg/kg). Our results indicate that EA has an inhibitory effect on the BK-induced pressor and ischemic dysfunction, which may be related with endogenous opioid peptide.
Chao
D M
DM
Department of Physiology, Shanghai Medical University, Shanghai 200032.
Shen
L L
LL
Cao
Y X
YX
Li
P
P
D000818:Animals; D001794:Blood Pressure / Q000502:physiology*; D001920:Bradykinin / Q000494:pharmacology*; D002415:Cats; D015671:Electroacupuncture; D005260:Female; D005704:Gallbladder / Q000502:physiology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D016277:Ventricular Function, Left / Q000502:physiology*
D009270:Naloxone; D001920:Bradykinin