A case of amelogenesis imperfecta of deciduous and all permanent teeth.
We experienced a case with severe enamel defects of both the deciduous teeth and all the permanent teeth. In order to clarify the etiology of enamel defects in this patient, we performed a DNA analysis in addition to conventional examinations. Although we suspected a variety of systemic factors causing enamel defects, there was no evidence suggesting disturbances of amelogenesis. In the present case, we suspected a mutation in the amelogenin gene and performed nucleotide sequencing of the exons of the amelogenin gene, but we could not find any evidence of mutation. We suggest that a mutation of some other gene related to enamel formation or the adventitious factors contributed to the amelogenesis imperfecta in this case.
Sekiguchi
H
H
Department of Pediatric Dentistry, Tokyo Dental College, Chiba, Japan.
Tanakamaru
H
H
Minaguchi
K
K
Machida
Y
Y
Yakushiji
M
M
D000293:Adolescent; D000567:Amelogenesis Imperfecta / Q000235:genetics*; D053523:Amelogenin; D004247:DNA / Q000235:genetics; D003744:Dental Enamel Hypoplasia / Q000235:genetics; D003746:Dental Enamel Proteins / Q000235:genetics; D005091:Exons / Q000235:genetics; D005260:Female; D006801:Humans; D009154:Mutation / Q000235:genetics; D017422:Sequence Analysis, DNA; D014070:Tooth / Q000473:pathology*; D014094:Tooth, Deciduous / Q000473:pathology*
D053523:Amelogenin; D003746:Dental Enamel Proteins; D004247:DNA