Renal potassium-chloride cotransporters.
The electroneutral cotransport of potassium and chloride is mediated by potassium-chloride transporters, which are encoded by members of the gene family of cation-chloride cotransporters. A significant body of evidence argues for swelling-activated, basolateral potassium-chloride transport in the proximal tubule and thick ascending limb, with a potential role in transepithelial salt transport. However, the lack of specific inhibitors has impeded progress in this area. The cloning of the four potassium-chloride cotransporter genes has sparked new interest in this transport pathway, and promises to yield novel insights into their roles in cellular and renal physiology.
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Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2372, USA. david.mount@mcmail.vanderbilt.edu
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D000595:Amino Acid Sequence / Q000235:genetics; D000818:Animals; D018076:DNA, Complementary / Q000235:genetics / Q000502:physiology; D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D027981:Symporters / Q000235:genetics / Q000378:metabolism*; D014018:Tissue Distribution; D000096922:K Cl- Cotransporters
D018076:DNA, Complementary; D027981:Symporters; D000096922:K Cl- Cotransporters; C119650:SLC12A6 protein, human; C119651:SLC12A7 protein, human