title: Cholelithiasic disease and associated factors in a Spanish population.
abstract: In order to analyze the factors associated with cholelithiasic disease, 1268 participants of a population sample were studied. On univariate analysis, 11 of the 23 variables included showed a statistically significant association (P < 0.05). Five of these variables, including obesity, triglyceride level, intake of hypolipidemic drugs, and a diet rich in cholesterol and saturated fats in women, and physical exercise in men, remained significantly associated after controlling for age. On multivariate analysis among women, a positive association was found with age (P < 0.001), obesity, and the use of hypolipidemic agents (P < 0.05) and a negative one with a diet rich in cholesterol and saturated fats (P < 0.05). Among men, the same analysis revealed there was a positive association with age (P < 0.001) and triglycerides (P < 0.05) and a negative one with physical exercise (P < 0.05). In conclusion, obesity and the use of hypolipidemic agents in women and triglycerides in men, were positively associated with cholelithiasic disease, independent of age, while negative associations included the intake of cholesterol and saturated fats in women and physical exercise in men.
authors.affiliation: Service of Internal Medicine, Hospital Francesc de Borja, Gandia, Valencia, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Devesa
authors.forename: J
authors.initials: J
authors.lastname: Ferrando
authors.forename: M
authors.initials: M
authors.lastname: Caldentey
authors.forename: A
authors.initials: A
authors.lastname: Borghol
authors.forename: M J
authors.initials: MJ
authors.lastname: Moreno
authors.forename: A
authors.initials: A
authors.lastname: Nolasco
authors.forename: J
authors.initials: J
authors.lastname: Moncho
authors.forename: J
authors.initials: J
authors.lastname: Berenguer
mesh_terms: D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D015992:Body Mass Index; D002769:Cholelithiasis / Q000453:epidemiology* / Q000209:etiology* / Q000235:genetics; D003276:Contraceptives, Oral / Q000009:adverse effects; D048909:Diabetes Complications; D004032:Diet; D015444:Exercise; D005260:Female; D006801:Humans; D000960:Hypolipidemic Agents / Q000009:adverse effects; D007422:Intestines / Q000502:physiology; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D010298:Parity; D011247:Pregnancy; D015995:Prevalence; D012907:Smoking / Q000009:adverse effects; D013030:Spain / Q000453:epidemiology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003276:Contraceptives, Oral; D000960:Hypolipidemic Agents