title: Gemcitabine in pre-treated advanced renal carcinoma: a feasibility study.
abstract: Eigtheen patients affected by metastatic renal cell carcinoma, 16 which were assesable, were treated with 1 g/m2 of Gemcitabine (GCB) on days 1, 8 and 15 of a 28-day treatment cycle up to a maximun of ten cycles. All patients in neoplastic progression were treated with chemo- and immunotherapy (5 FU, IL-2, IFN alpha d 13-cis-retinoic acid.) Out of the 16 assessable patients, 5/16 (31%) showed overall response (ICR, 4 PR), 5 (31%) stable disease (SD) and 6 (38%) progression of disease (PD). Toxicity was limited to WHO grades I only, primarily hematological.
authors.affiliation: S.C. Oncologia medica C, Istituto Regina Elena, Roma, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Casali
authors.forename: M
authors.initials: M
authors.lastname: Marcellini
authors.forename: A
authors.initials: A
authors.lastname: Casali
authors.forename: T
authors.initials: T
authors.lastname: Giuntini
authors.forename: E
authors.initials: E
authors.lastname: Galante
authors.forename: C
authors.initials: C
authors.lastname: Ferrone
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects / Q000627:therapeutic use*; D002292:Carcinoma, Renal Cell / Q000188:drug therapy* / Q000556:secondary; D003841:Deoxycytidine / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D018450:Disease Progression; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D000093542:Gemcitabine
chemical_list: D000964:Antimetabolites, Antineoplastic; D003841:Deoxycytidine; D000093542:Gemcitabine