title: Hypnotic dependence: zolpidem and zopiclone too.
abstract: (1) Loss of efficacy can occur after a few weeks of treatment with zolpidem and zopiclone.  This is not a reason to increase the dose.  (2) Zolpidem and zopiclone carry a risk of dependence and of potentially severe disorders (e.g. seizures) during withdrawal.  (3) The risk-benefit ratio of benzodiazepines and related drugs (zopiclone and zolpidem) remains more favourable than that of other drugs used in insomnia.  However, first-line treatment of sleep disorders should not necessarily be drug-based.
mesh_terms: D001569:Benzodiazepines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D004361:Drug Tolerance; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D010879:Piperazines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D011725:Pyridines / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D019966:Substance-Related Disorders; D013997:Time Factors; D016896:Treatment Outcome; D014481:United States
chemical_list: D006993:Hypnotics and Sedatives; D010879:Piperazines; D011725:Pyridines; D001569:Benzodiazepines