title: Selective expression of angiopoietin 1 and 2 in mesenchymal cells surrounding veins and arteries of the avian embryo.
abstract: The expression of angiopoietin1 and 2 (ang1 and 2) and their receptor tie-2 was studied in avian embryos using in situ hybridization. Ang1 was transcribed in the mesenchymal cells surrounding venous endothelium expressing tie-2. By contrast, ang2 was transcribed around arteries in which the endothelium down-regulated tie-2 mRNA. The aorta and large arteries of the heart outflow tract were never surrounded by ang2 positive cells and maintained tie-2 expression.
authors.affiliation: Institut d'Embryologie Cellulaire et Moléculaire CNRS FRE 2160, 49bis, Avenue de la Belle Gabrielle, 94736 Cedex, Nogent-sur-Marne, France.
authors.forename: D
authors.initials: D
authors.lastname: Moyon
authors.forename: L
authors.initials: L
authors.lastname: Pardanaud
authors.forename: L
authors.initials: L
authors.lastname: Yuan
authors.forename: C
authors.initials: C
authors.lastname: Bréant
authors.forename: A
authors.initials: A
authors.lastname: Eichmann
mesh_terms: D042683:Angiopoietin-1; D042702:Angiopoietin-2; D000818:Animals; D001011:Aorta / Q000196:embryology / Q000378:metabolism; D001158:Arteries / Q000196:embryology*; D002642:Chick Embryo; D015536:Down-Regulation; D004730:Endothelium, Vascular / Q000166:cytology / Q000196:embryology / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D006321:Heart / Q000196:embryology; D017403:In Situ Hybridization; D008208:Lymphatic System / Q000196:embryology; D008562:Membrane Glycoproteins / Q000235:genetics*; D008648:Mesoderm / Q000166:cytology / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000235:genetics; D011506:Proteins / Q000235:genetics* / Q000378:metabolism; D011518:Proto-Oncogene Proteins; D011784:Quail / Q000196:embryology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D042787:Receptor, TIE-2; D014680:Veins / Q000196:embryology*
chemical_list: D042683:Angiopoietin-1; D042702:Angiopoietin-2; C105373:MEN1 protein, human; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D042787:Receptor, TIE-2