title: Flavonoids as cycline-dependent kinase inhibitors: inhibition of cdc 25 phosphatase activity by flavonoids belonging to the quercetin and kaempferol series.
abstract: In an effort to detect potential inhibitors of cdc25 phosphatase, nineteen flavonoids belonging to the quercetin and kaempferol series have been evaluated, using a colorimetric assay of recombinant human cdc25A tyrosine phosphatase as a cell cycle-specific target. Compounds bearing two benzyl or methyl groups in positions 7 and 4' and acetyl on the hydroxy groups of the sugar moiety showed the maximal activity.
authors.forename: N
authors.initials: N
authors.lastname: Aligiannis
authors.forename: S
authors.initials: S
authors.lastname: Mitaku
authors.forename: D
authors.initials: D
authors.lastname: Mitrocotsa
authors.forename: S
authors.initials: S
authors.lastname: Leclerc
mesh_terms: D001681:Biological Assay; D002455:Cell Division; D002478:Cells, Cultured; D003124:Colorimetry; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004926:Escherichia coli / Q000166:cytology; D005419:Flavonoids; D006801:Humans; D044949:Kaempferols; D019684:Magnoliopsida / Q000737:chemistry* / Q000166:cytology; D016200:Maturation-Promoting Factor; D015394:Molecular Structure; D011794:Quercetin / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology*; D020687:cdc25 Phosphatases / Q000037:antagonists & inhibitors* / Q000378:metabolism
chemical_list: D005419:Flavonoids; D044949:Kaempferols; C006552:kaempferol; D011794:Quercetin; D018844:Cyclin-Dependent Kinases; D016200:Maturation-Promoting Factor; D020687:cdc25 Phosphatases