The glutamine/glutamate couplet and cellular function.
All cells require glutamine as a nitrogen donor as well as an energy source for cell-specific functions. Understanding how glutamine utilization is metered to these demands is fundamental to basic cell processes as well as to therapeutic manipulation of regulatory mechanisms. The regulatory role of the glutamine/glutamate couplet in cellular function is illustrated for acid-base homeostasis and for production of the extracellular matrix.
Welbourne
T
T
Department of Molecular and Cellular Physiology, Louisiana State University Health Sciences Center, Shreveport, Louisiana 71130, USA.
Routh
R
R
Yudkoff
M
M
Nissim
I
I
D000138:Acidosis / Q000378:metabolism; D000818:Animals; D002468:Cell Physiological Phenomena; D002839:Chromans / Q000494:pharmacology; D003600:Cytosol / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism*; D013844:Thiazoles / Q000494:pharmacology; D045162:Thiazolidinediones; D000077288:Troglitazone
D002839:Chromans; D013844:Thiazoles; D045162:Thiazolidinediones; D005973:Glutamine; D018698:Glutamic Acid; D000077288:Troglitazone