A new vascularized adrenal transplantation model in the rat.
A new microsurgical model of adrenal transplantation in the rat is described. An adrenal graft with its vascular supply, adrenal artery and vein, and the attachment of a segment of aorta and inferior vena cava (IVC) was transplanted to a recipient rat with end-to-side anastomoses between the donor IVC segment and the recipient IVC and between the donor aortic segment and the recipient aorta using 10-0 nylon sutures. Using this model, different groups of recipient rats received iso- or allograft with or without immunosuppressive treatment were tested. This model provides a reliable and useful tool for research on endocrinology.
Liu
D
D
Laboratory of Experimental Surgery, Research Center of CHUM, Notre-Dame Hospital, University of Montreal, 1560 Sherbrooke Street East, Montreal, Quebec H2L 4M1, Canada.
Qi
S
S
Xu
D
D
Zhu
S
S
Chen
H
H
D000311:Adrenal Glands / Q000098:blood supply / Q000637:transplantation*; D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D016572:Cyclosporine / Q000494:pharmacology; D006085:Graft Survival / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000494:pharmacology; D008297:Male; D008866:Microsurgery; D051381:Rats; D011914:Rats, Inbred BN; D011917:Rats, Inbred Lew; D020123:Sirolimus / Q000494:pharmacology; D014184:Transplantation, Homologous; D014185:Transplantation, Isogeneic; D014682:Vena Cava, Inferior / Q000601:surgery
D007166:Immunosuppressive Agents; D016572:Cyclosporine; D020123:Sirolimus