title: Effect of hypothermia on brain cell membrane function and energy metabolism in experimental Escherichia coli meningitis in the newborn piglet.
abstract: We evaluated the anti-inflammatory and neuroprotective effects of hypothermia during the early phase of experimental Escherichia coli meningitis in the newborn piglet. Hypothermia significantly attenuated the meningitis-induced acute inflammatory responses such as increased intracranial pressure, decreased glucose level, increased lactate concentration, increased tumor necrosis factor-alpha level and leukocytosis in the cerebrospinal fluid. Decreased cerebral cortical cell membrane Na+,K+-ATPase activity and increased lipid peroxidation products, indicative of meningitis-induced brain damage, were significantly improved with hypothermia. Hypothermia also significantly improved the meningitis-induced reduction in brain ATP and phosphocreatine levels. In summary, hypothermia significantly attenuated the acute inflammatory responses and the ensuing brain injury in experimental neonatal bacterial meningitis.
authors.affiliation: Department of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
authors.forename: W S
authors.initials: WS
authors.lastname: Park
authors.forename: Y S
authors.initials: YS
authors.lastname: Chang
authors.forename: M
authors.initials: M
authors.lastname: Lee
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002462:Cell Membrane / Q000201:enzymology / Q000378:metabolism; D002540:Cerebral Cortex / Q000201:enzymology / Q000378:metabolism / Q000503:physiopathology*; D004734:Energy Metabolism; D005947:Glucose / Q000134:cerebrospinal fluid / Q000378:metabolism; D007035:Hypothermia; D019344:Lactic Acid / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism; D007958:Leukocyte Count; D015227:Lipid Peroxidation; D020814:Meningitis, Escherichia coli / Q000378:metabolism / Q000503:physiopathology*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism; D013552:Swine; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D014409:Tumor Necrosis Factor-alpha; D019344:Lactic Acid; D000254:Sodium-Potassium-Exchanging ATPase; D005947:Glucose