CD1-specific T cells in microbial immunity.
Recent results strengthen evidence that CD1-restricted T cells play important roles in host defense against microbial infections. Human subjects recently infected with Mycobacterium tuberculosis showed elevated responses to CD1c-mediated presentation of a microbial lipid antigen, compared with control donors. Activation of CD1d-restricted NKT cells with a synthetic glycolipid antigen results in improved immune responses to several infectious pathogens.
Gumperz
J E
JE
Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Smith Building, Room 518, Boston, MA 02115, USA. jgumperz@rics.bwh.harvard.edu
Brenner
M B
MB
D000818:Animals; D017951:Antigen Presentation; D018949:Antigens, CD1 / Q000378:metabolism*; D006801:Humans; D007239:Infections / Q000276:immunology*; D007694:Killer Cells, Natural / Q000276:immunology; D008055:Lipids / Q000276:immunology; D008954:Models, Biological; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology
D018949:Antigens, CD1; D008055:Lipids; D011948:Receptors, Antigen, T-Cell; D016692:Receptors, Antigen, T-Cell, gamma-delta