Zaltoprofen inhibits concanavalin A-induced decrease of body weight in mice.
Treatment of mice with concanavalin A (Con A) (12.5 mg/kg, i.v.) decreased the body weight at 24 h. This Con A-induced body weight decrease was accompanied by reduction in food and water intake. Zaltoprofen is a non-steroidal anti-inflammatory drug. The administration of Zaltoprofen (10 mg/kg) at 8 h after Con A treatment was found to inhibit the Con A-induced reduction in body weight. The food intake in mice treated with Con A plus Zaltoprofen (10 mg/kg) was four times greater than that in mice treated with only Con A. The present results showed inhibition of the Con A-induced body weight loss by Zaltoprofen and suggested its possible effectiveness for the treatment of "sickness behavior".
Okamoto
T
T
Research Laboratories, Nippon Chemiphar Co., Ltd., Saitama 341-0005, Japan.
Kawasaki
T
T
Masuda
Y
Y
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001578:Benzopyrans / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D011422:Propionates / Q000494:pharmacology*; D015431:Weight Loss / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D011422:Propionates; D003208:Concanavalin A; C043940:pyranoprofen