[Effects of microwave baking on the immunological cells in primary lymphedema patients].
OBJECTIVE
To elucidate the effects of microwave on the immunological cells in primary lymphedema.


METHODS
The immunological cells including lymphocytes in the affected limb skin and peripheral blood of 10 patients with primary lower limb lymphedema were analysed using ABC and APAAP immunohistochemical methods before and after microwave baking and bandaging treatment.


RESULTS
It is demonstrated that in the peripheral blood of the patients there was an increase of CD8+ T lymphocytes as well as a decrease of CD4+ T lymphocytes and the ratio of CD4/CD8. It was found that there was significant perivascular infiltration of mononuclear cells (most were monocytes and macrophages) in the skin of the affected limb.


CONCLUSIONS
Microwave modulates the systemic immunological imbalance by its heating and complex biological effects on primary lymphedema patients through reversing the ratio of CD4/CD8 to normal level by increasing CD4+ T lymphocytes and decreasing CD8+ T lymphocytes. It can also decrease the perivascular T-lymphocyte infiltration of the affected dermis and enhance the phagocytic capabilities by promoting the proteolytic activities of macrophages, finally resulting in edema resolution.
Cao
W
W
Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Shanghai 200011.
Zhang
D
D
Gan
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D002648:Child; D002908:Chronic Disease; D003972:Diathermy; D005260:Female; D006801:Humans; D008209:Lymphedema / Q000276:immunology* / Q000628:therapy*; D008297:Male; D008872:Microwaves / Q000627:therapeutic use*; D008875:Middle Aged