title: Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease.
abstract: Purpose: To test the influence of nerve growth factor (NGF) on striatal glutathione (GSH) content and the activities of GSH-related enzymes from quinolinic acid-lesioned rats. Methods: Rats were intrastriatally injected with QA and NGF. Enzymatic and GSH assays were performed one week later. Results: NGF prevented the QA-induced decline in glutathione reductase activity and GSH content. Conclusions: NGF is able to prevent some of the disturbances induced by the excitotoxic insult in the striatal GSH metabolism.
authors.affiliation: Neurochemistry Laboratory, International Center for Neurological Restoration, Havana, Cuba.
authors.forename: Reyniel
authors.initials: R
authors.lastname: Cruz-Aguado
authors.forename: Liliana Francis
authors.initials: LF
authors.lastname: Turner
authors.forename: Carmen M.
authors.initials: CM
authors.lastname: Díaz
authors.forename: Janet
authors.initials: J
authors.lastname: Piñero