Regulation of ROMK trafficking and channel activity.
ROMK potassium channels are present in the thick ascending limbs and cortical collecting ducts of the kidney and are responsible for potassium ion efflux in these segments. ROMK channels are regulated by multiple signalling pathways. This review focuses on recent advances in the regulation of ROMK channels by phosphatidylinositol-4,5-bisphosphate and by membrane trafficking. Relevant publications on the related inward rectifier potassium channels will also be discussed.
Huang
C L
CL
Division of Nephrology, Department of Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390-8856, USA. chou-long.huang@mednet.swmed.edu
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D007668:Kidney / Q000378:metabolism*; D019269:Phosphatidylinositol 4,5-Diphosphate / Q000502:physiology*; D015221:Potassium Channels / Q000378:metabolism*; D024661:Potassium Channels, Inwardly Rectifying
D019269:Phosphatidylinositol 4,5-Diphosphate; D015221:Potassium Channels; D024661:Potassium Channels, Inwardly Rectifying