[Effect of Salvia Miltiorrhiza injection on umbilical artery hemodynamics during fetal distress in ewe].
OBJECTIVE
To study the effect of Salvia Miltiorrhiza injection (SMI) on umbilical artery hemodynamics during fetal distress in ewe.


METHODS
Intrauterine surgery were performed at 116-125 gestational days in 3 pregnancy sheep for insertion of vascular catheters at abdominal aorta from femoral artery and for implantation of a electromagnetic flowmetre probe around umbilical artery. Gelatin microsphere injection to abdominal aorta through vascular catheter for obstruction of placental-fetal circulation. 2 ml of SMI was used 6 times(2 times each sheep), and the signs of umbilical artery blood flow and wave forms of fetal abdominal aorta blood pressure were recorded before and after injections of gelatin microsphere or SMI. The fast Fourier translation (FFT) was used to turn signs in time domain into powers spectral of input impedance in frequency domain for resistance and characteristic impedance of umbilical artery.


RESULTS
After the SMI was injected into fetal abdominal aorta, the resistance of umbilical artery was significantly reduced (P < 0.05), and the changes of resistance was significantly relative with the resistance before SMI injected (r = -0.85, P < 0.001). But there were no significantly different impedance between before and after SMI treatment (P > 0.05).


CONCLUSIONS
The SMI to fetal abdominal aorta can decrease umbilical artery blood flow resistance and the changes of resistance was significantly relative to that before SMI treatment.
Li
X
X
Hospital of Obstetrics and Gynecology, Shanghai Medical University, Shanghai 200011.
Zhuang
Y
Y
Chang
C
C
D000818:Animals; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005316:Fetal Distress / Q000188:drug therapy* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D010936:Plant Extracts; D011247:Pregnancy; D027561:Salvia miltiorrhiza; D012756:Sheep; D014469:Umbilical Arteries / Q000503:physiopathology*; D014655:Vascular Resistance / Q000187:drug effects
D004365:Drugs, Chinese Herbal; D010936:Plant Extracts