Lichen planus-like eruption following autologous bone marrow transplantation for chronic myeloid leukaemia.
A 47-year-old female treated with an autologous bone marrow transplant and cytotoxic chemotherapy developed a lichen planus-like eruption 12 months later. It involved the skin and oral mucosa, with the histological features of a lichenoid graft-versus-host reaction, including satellite cell necrosis. This eruption developed de novo. The eruption resolved with topical betamethasone valerate 0.1% cream despite the ongoing use of the immunomodulatory agent interferon-alpha2b. Such a reaction in an autologous setting has only been described once previously.
Pagliaro
J A
JA
Department of Dermatology, Princess Alexandra Hospital, Brisbane, Queensland, Australia.
White
S
S
Strutton
G
G
Guerin
D
D
D000279:Administration, Cutaneous; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001624:Betamethasone Valerate / Q000008:administration & dosage; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D005260:Female; D005938:Glucocorticoids; D006087:Graft vs Host Reaction; D006801:Humans; D007279:Injections, Subcutaneous; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D008010:Lichen Planus / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D011994:Recombinant Proteins
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D005938:Glucocorticoids; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D001624:Betamethasone Valerate