Solubility and dissolution rate of ibuprofen in ionic and non-ionic micellar systems.
Equilibrium solubility, the profile and the rate of ibuprofen dissolution in solutions of sodium dodecyl sulfate, Tween 60 and Brij 35 were studied. It was found that the solubility of ibuprofen was enhanced by the formed micellar system. The size and shape of formed micelles depended on the used particular surfactant. The mechanism of ibuprofen dissolution in micellar system was discussed.
Kokot
Z
Z
Department of Inorganic & Analytical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.
Zmidzińska
H
H
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000737:chemistry*; D007052:Ibuprofen / Q000008:administration & dosage / Q000737:chemistry*; D008823:Micelles; D012965:Sodium Chloride / Q000494:pharmacology; D012967:Sodium Dodecyl Sulfate / Q000494:pharmacology; D012995:Solubility
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008823:Micelles; D012967:Sodium Dodecyl Sulfate; D012965:Sodium Chloride; D007052:Ibuprofen