title: Heart rate and heart rate variability changes in the intracarotid sodium amobarbital test.
abstract: OBJECTIVE
  Changes in heart rate and heart rate variability have been found in prior studies performed during the intracarotid sodium amobarbital (ISA) test. However, these results are not entirely consistent with current models of differential cerebral involvement in the modulation of the heart. This study was designed to re-investigate this topic with a larger N than has heretofore been used.
  
  
  METHODS
  The electrocardiogram was recorded during left and right ISAs in 73 subjects. Raw heart rate and heart rate variability were calculated.
  
  
  RESULTS
  Raw heart rate increased during inactivation of either hemisphere, but more so for the right hemisphere. Heart rate variability changes consistent with decreasing parasympathetic tone also were found to occur during either ISA, but to a significant degree, only during right ISA.
  
  
  CONCLUSIONS
  The right hemisphere appears to have a greater role in cerebral regulation of cardiac function, perhaps by virtue of the modification of parasympathetic effects.
authors.affiliation: Department of Neurology, University of Arizona Health Sciences Center, Tucson, Arizona 85724-5023, USA. gahern@u.arizona.edu
authors.forename: G L
authors.initials: GL
authors.lastname: Ahern
authors.forename: J J
authors.initials: JJ
authors.lastname: Sollers
authors.forename: R D
authors.initials: RD
authors.lastname: Lane
authors.forename: D M
authors.initials: DM
authors.lastname: Labiner
authors.forename: A M
authors.initials: AM
authors.lastname: Herring
authors.forename: M E
authors.initials: ME
authors.lastname: Weinand
authors.forename: R
authors.initials: R
authors.lastname: Hutzler
authors.forename: J F
authors.initials: JF
authors.lastname: Thayer
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000654:Amobarbital / Q000008:administration & dosage / Q000494:pharmacology*; D000704:Analysis of Variance; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002343:Carotid Artery, Internal; D004562:Electrocardiography / Q000187:drug effects / Q000706:statistics & numerical data; D004827:Epilepsy / Q000175:diagnosis*; D005260:Female; D007839:Functional Laterality / Q000187:drug effects* / Q000502:physiology; D006321:Heart / Q000294:innervation / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology
chemical_list: D000654:Amobarbital