title: Instrumental planar chromatographic determination of benzodiazepines: comparison with liquid chromatography and gas chromatography.
abstract: Diazepam, chlordiazepoxide, and midazolam are determined by high-perfromance, thin-layer chromatography (HPTLC). Results are compared with those obtained by liquid chromatography (LC) and gas chromatography (GC). Analytical conditions for all the methods are also described. Validation parameters for linearity, precision, detection, and quantitative limits are informed. Correlation study of HPTLC with LC and GC gave a correlation factor between 0.98 and 0.99. The obtained results showed that HPTLC, LC, and GC techniques are comparable for determination of such benzodiazepins in the requested working range to be analyzed in raw materials.
authors.affiliation: Universidad de Concepción, Facultad de Farmacia, Chile.
authors.forename: R
authors.initials: R
authors.lastname: Saelzer
authors.forename: G
authors.initials: G
authors.lastname: Godoy
authors.forename: M
authors.initials: M
authors.lastname: Vega
authors.forename: M
authors.initials: M
authors.lastname: de Diego
authors.forename: R
authors.initials: R
authors.lastname: Godoy
authors.forename: G
authors.initials: G
authors.lastname: Ríos
mesh_terms: D001569:Benzodiazepines / Q000032:analysis*; D002849:Chromatography, Gas; D002853:Chromatography, Liquid; D002855:Chromatography, Thin Layer
chemical_list: D001569:Benzodiazepines