[Retinoic acid--a teratogenic factor in caudal dysgenesis. Experimental models and hypothesis for pathogenesis].
Using teratogen--trans-retinoic acid (Sigma Chemical)--caudal malformations are experimentally induced in mice of the Spriche-Dolly breed. For the purpose the aforementioned reagent is injected into pregnant mice at 6-hour intervals dose 29 mg/kg. In stages between two and four paired somites, supravital staining with Nile blue sulfite (in 1:50,000 Ringer solution at 37 degrees C for 30 min) is done, followed by histological assessment of tissue sections. The malformation noted are summed up in an attempt to draw conclusions about their presumable pathogenesis.
Krŭstev
N
N
Krŭstev
D
D
Iarŭmov
N
N
D000818:Animals; D002420:Cauda Equina / Q000002:abnormalities*; D005260:Female; D051379:Mice; D023421:Models, Animal; D011247:Pregnancy; D013723:Teratogens / Q000494:pharmacology*; D014212:Tretinoin / Q000633:toxicity*
D013723:Teratogens; D014212:Tretinoin