[The relationship between angiogenesis and p53 overexpression in endometrioid adenocarcinoma].
OBJECTIVE
To determine the relationship between angiogenesis and p53 overexpression and explore the relationship between angiogenesis and clinicopathologic features in endometrioid adenocarcinoma.


METHODS
Angiogenesis was evaluated by intratumoral microvessel density (IMD). Eighty-five endometrioid adenocarcinomas' IMD were identified by immunohistochemical staining of endothelial cells for factor VIII-related antigen, and the expression of p53 protein was stained with the same method by it's monoclone antibody.


RESULTS
(1) The positive rate of p53 expression in endometrioid adenocarcinoma was 50.6%. The positive rate in stage III-IV (69.2%) was higher than that in stage I-II(42.4%) (P < 0.05). (2) IMD was higher in stage III-IV (13.27 +/- 6.14) than that in stage I-II (8.31 +/- 4.78) (P < 0.01). IMD in G1, G2 and G3 was 8.95 +/- 5.51, 9.28 +/- 4.87 and 14.73 +/- 7.66, respectively (P < 0.05). In groups of non-myoinvasion, < 1/2 myoinvasion and > or = 1/2 myoinvasion, IMD was 8.45 +/- 5.53, 8.95 +/- 4.99 and 11.96 +/- 6.39, respectively (P < 0.05). (3) In negative, weakly positive and strong positive groups of p53 overexpression, IMD was 5.52 +/- 2.11, 11.75 +/- 4.18 and 16.00 +/- 4.63, respectively (P < 0.01).


CONCLUSIONS
Angiogenesis tightly correlated with clinicopathologic factors, such as stage, grade and myoinvasion, is promoted by p53 overexpression in endometrioid adenocarcinoma. It can be concluded that angiogenesis may act as a predictor of prognosis of endometrioid adenocarcinoma.
Yao
Y
Y
Second Hospital, West China University of Medical Sciences, Chengdu 610041.
Peng
Z
Z
Yin
R
R
D000328:Adult; D000368:Aged; D018269:Carcinoma, Endometrioid / Q000235:genetics*; D016889:Endometrial Neoplasms / Q000098:blood supply* / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009389:Neovascularization, Pathologic; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53