[Molecular basis of carcinogenesis in lung cancer induced by cigarette smoking].
An association between cigarette smoking and lung cancer carcinogenesis is reviewed. It is highly possible, that "individual susceptibility" for tumor development exists and is related to polymorphic variants of genes encoding for enzymes, which are employed in metabolism of xenobiotic substances. The gathering of highly reactive molecules due to modified metabolic processes results in DNA adducts forming and increased tendency for mutations. Group of genes, responsible for proliferation, cell cycle arrest, apoptosis and DNA damage repair are frequently altered.
Damps
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I
Klinika Chorób Płuc i Gruźlicy Akademii Medycznej w Gdańsku.
Jassem
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E
Siemińska
A
A
D019363:Cytochrome P-450 CYP1A1 / Q000235:genetics*; D018736:DNA Adducts / Q000235:genetics; D005982:Glutathione Transferase / Q000235:genetics / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood / Q000139:chemically induced* / Q000235:genetics*; D008214:Lymphocytes / Q000378:metabolism; D009538:Nicotine / Q000009:adverse effects*; D017354:Point Mutation / Q000235:genetics; D012333:RNA, Messenger / Q000097:blood / Q000235:genetics; D012907:Smoking / Q000009:adverse effects*
D018736:DNA Adducts; D012333:RNA, Messenger; D009538:Nicotine; D019363:Cytochrome P-450 CYP1A1; D005982:Glutathione Transferase