[Role of type IV collagene and type IV collagenase in the invasion and metastasis of salivary adenoid cystic carcinoma].
Using immunohistochemical ABC method, the authors studied the distribution of type IV collagen and type IV collagenase in 25 cases ACC. The result showed type IV collagen was found in vascular and epithelial basement membrance, and in partly cyst of sieve-like and tubular pattern, and in cytoplasm of tumor cell. Type IV collagenase was detected in membrance and cytoplasm of tumor cell. Expression of type IV collagen and type IV collagenase were correlated with pathologic type, TNM stage and metastasis. Much positive staining of type IV collagen was found in sieve-tubular pattern, early stage of TNM and without metastasis, but much positive staining of type IV collagenase was found in solid pattern, later stage of TNM and metastasis. The result suggested that the loss of type IV collagen and over-expression of type IV collagenase may be markers of malignance of ACC.
Shi
H
H
Department of Oral and Maxillofacial Surgery, Affiliated Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University.
He
R
R
Lin
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G
D014408:Biomarkers, Tumor; D003528:Carcinoma, Adenoid Cystic / Q000378:metabolism* / Q000473:pathology; D003094:Collagen / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism / Q000556:secondary; D008207:Lymphatic Metastasis; D020780:Matrix Metalloproteinase 9 / Q000378:metabolism*; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D012468:Salivary Gland Neoplasms / Q000378:metabolism* / Q000473:pathology
D014408:Biomarkers, Tumor; D003094:Collagen; D020780:Matrix Metalloproteinase 9