Post-ischemic hypothermia blocks caspase-3 activation in the newborn rat brain after hypoxia-ischemia.
The effects of hypothermia on caspase-3 activation were investigated in the newborn rat brain after hypoxia-ischemia (HI). Intense caspase-3 activation was observed in the control brains after HI, but this activation was significantly reduced by postischemic hypothermia. These findings suggest that the inhibition of caspase-3 activation may be an interventional point underlying the neuroprotective effect of hypothermia in neonates.
Fukuda
H
H
Department of Obstetrics and Gynecology, Osaka University School of Medicine, 2-2 Yamada-oka, Suita 565-0871, Japan. fukuda@gyne.med.osaka-u.ac.jp
Tomimatsu
T
T
Watanabe
N
N
Mu
J W
JW
Kohzuki
M
M
Endo
M
M
Fujii
E
E
Kanzaki
T
T
Murata
Y
Y
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D017209:Apoptosis / Q000502:physiology; D001831:Body Temperature / Q000502:physiology*; D001921:Brain / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D053148:Caspase 3; D020169:Caspases / Q000378:metabolism*; D004195:Disease Models, Animal; D007036:Hypothermia, Induced; D020925:Hypoxia-Ischemia, Brain / Q000201:enzymology* / Q000503:physiopathology / Q000628:therapy; D007150:Immunohistochemistry; D008869:Microtubule-Associated Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley
D008869:Microtubule-Associated Proteins; C505410:Casp3 protein, rat; D053148:Caspase 3; D020169:Caspases