Pharmacological comparison of human homomeric 5-HT3A receptors versus heteromeric 5-HT3A/3B receptors.
The present study determined the detailed pharmacological profile of heterologously expressed human (h) homomeric 5-HT3A receptors in direct comparison to heteromeric h5-HT3A/3B receptors. The very minor differences in their respective pharmacological profiles indicates that the 5-HT3B receptor subunit alters, predominantly, the biophysical rather than the pharmacological properties of the 5-HT3 receptor.
Brady
C A
CA
Department of Pharmacology, The Medical School, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Stanford
I M
IM
Ali
I
I
Lin
L
L
Williams
J M
JM
Dubin
A E
AE
Hope
A G
AG
Barnes
N M
NM
D016166:Free Radical Scavengers / Q000494:pharmacology; D006801:Humans; D015640:Ion Channel Gating; D007668:Kidney / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D011985:Receptors, Serotonin / Q000096:biosynthesis* / Q000145:classification; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin / Q000494:pharmacology
D016166:Free Radical Scavengers; D011985:Receptors, Serotonin; D044406:Receptors, Serotonin, 5-HT3; D012701:Serotonin