Circadian changes in the pharmacokinetics of triamcinolone acetonide in rabbits.
Circadian changes in the pharmacokinetics of triamcinolone acetonide were investigated in rabbits after a single intravenous administration of the drug, 1.0 mg/kg, at 08:00 and 20:00. At 20:00 hrs, the area under the plasma concentration-time curve from time zero to time infinity was significantly greater (46% increase), and this could be due to significantly slower total body clearance (31% decrease) than that at 08:00. The terminal half-life was significantly longer (82%) at 20:00. However, the apparent volume of distribution at steady state and total amount of unchanged drug excreted in 12 hr urine were not significantly different between two groups of rabbits.
Choi
J S
JS
College of Pharmacy, Chosun University, Kwangju, Korea. jsachoi@mail.chosun.ac.kr
Shin
S C
SC
Burm
J P
JP
D000818:Animals; D019540:Area Under Curve; D002851:Chromatography, High Pressure Liquid; D002940:Circadian Rhythm; D008297:Male; D011817:Rabbits; D012015:Reference Standards; D014222:Triamcinolone Acetonide / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine
D014222:Triamcinolone Acetonide