title: Pigmented neurofibroma: report of two cases and literature review.
abstract: Two cases of pigmented neurofibroma of the skin are reported. In case 1, the tumor was removed from the back of a 55-year-old man with no associated neurofibromatosis. In case 2, the tumor was removed from the abdominal wall of a 21-year-old woman with neurofibromatosis. Both tumors consisted of benign, short spindle cells and multiple foci of scattered melanin-laden cells. In case 1, the spindle cells were arranged in a storiform pattern, resembling features of dermatofibrosarcoma protuberans. Immunohistochemically, the spindle cells of both cases were demonstrated to be positive for S-100 protein and CD34. The melanin-laden cells stained positively for HMB-45. This report describes an additional two cases of pigmented neurofibroma that conform to the new diagnostic criteria for this disease.
authors.affiliation: Department of Pathology, Kobe University School of Medicine, Kobe, Japan. inaba@med.kobe-u.ac.jp
authors.forename: M
authors.initials: M
authors.lastname: Inaba
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: R
authors.initials: R
authors.lastname: Minami
authors.forename: C
authors.initials: C
authors.lastname: Ohbayashi
authors.forename: K
authors.initials: K
authors.lastname: Hanioka
mesh_terms: D000328:Adult; D018952:Antigens, CD34 / Q000032:analysis; D000951:Antigens, Neoplasm; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D018223:Dermatofibrosarcoma / Q000175:diagnosis; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008543:Melanins / Q000378:metabolism; D058950:Melanoma-Specific Antigens; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009455:Neurofibroma / Q000737:chemistry / Q000473:pathology* / Q000601:surgery; D010858:Pigmentation; D009418:S100 Proteins / Q000032:analysis; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000601:surgery
chemical_list: D018952:Antigens, CD34; D000951:Antigens, Neoplasm; D008543:Melanins; D058950:Melanoma-Specific Antigens; D009363:Neoplasm Proteins; D009418:S100 Proteins