title: Arterial reconstruction for lower limb ischemia.
abstract: The treatment of advanced atherosclerosis involving the lower extremities has undergone considerable evolution over the last several decades. Current strategies hinge on an appreciation of the natural history of disease, the overall health status of the patient, and an armamentarium of endovascular and open surgical reconstructive techniques that may be tailored to optimize outcome for the individual patient. Patients with aorto-iliac disease have a variety of available options with generally good results. For infrainguinal disease, surgical bypass using autogenous vein is the mainstay of interventional therapy and will remain so for the foreseeable future. Increasing medical and surgical challenges are presented by this population, particularly as aggressive medical treatment of risk factors leads to an ongoing decline in cardiovascular mortality, combined with a dramatic increase in the prevalence of diabetes. The future, which is now already at hand, will bring the application of genomics, with a potential for altering the progression of disease as well as extending the long-term benefits of reconstruction.
authors.affiliation: Division of Vascular Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.
authors.forename: D K
authors.initials: DK
authors.lastname: Chew
authors.forename: M S
authors.initials: MS
authors.lastname: Conte
authors.forename: M
authors.initials: M
authors.lastname: Belkin
authors.forename: M C
authors.initials: MC
authors.lastname: Donaldson
authors.forename: A D
authors.initials: AD
authors.lastname: Whittemore
mesh_terms: D019917:Blood Vessel Prosthesis Implantation; D006801:Humans; D007383:Intermittent Claudication / Q000175:diagnosis / Q000601:surgery; D007511:Ischemia / Q000175:diagnosis / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D014656:Vascular Surgical Procedures / Q000379:methods*; D014680:Veins / Q000637:transplantation