Lead compounds discovered from libraries.
Lead compounds with the potential to progress to viable drug candidates have been identified from libraries using several strategies. These include rapid screening of large diverse collections, thematic libraries, project-directed libraries, and three-dimensional molecular models of corporate databases. There have been numerous success stories, including the identification of several clinical candidates.
Golebiowski
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Procter & Gamble Pharmaceuticals, Health Care Research Center 45040-8006, Mason, OH, USA. golebiowskia@pg.com
Klopfenstein
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Portlock
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D020650:Combinatorial Chemistry Techniques; D015195:Drug Design; D011506:Proteins / Q000737:chemistry
D011506:Proteins