title: Synthesis of alpha-substituted beta-amidophosphines by diastereoselective alkylation. A new access to chiral ligands for asymmetric catalysis.
abstract: Chiral beta-amidophosphine boranes 7a-f can be diastereoselectively alkylated, using O-protected amino-alcohols as chiral inducers, to furnish alpha-substituted beta-amidophosphine boranes 8a-f and 9-12 with up to 72% diastereoisomeric excess. Selective deprotection afforded optically pure carboxylic derivative 13 which is a key intermediate for the synthesis of various potential chiral ligands for asymmetric catalysis.
authors.affiliation: Laboratoire d'Hétérochimie Organique associé au CNRS, IRCOF, INSA et Université de Rouen, 1 rue Tesnière, 76821 Mont Saint-Aignan Cedex, France.
authors.forename: M
authors.initials: M
authors.lastname: Léautey
authors.forename: G
authors.initials: G
authors.lastname: Castelot-Deliencourt
authors.forename: P
authors.initials: P
authors.lastname: Jubault
authors.forename: X
authors.initials: X
authors.lastname: Pannecoucke
authors.forename: J C
authors.initials: JC
authors.lastname: Quirion