High frequency of the HIV-1 protective CCR5 delta32 deletion in native Estonians.
In previous studies, the highest frequencies (16%) of the CCR5 delta32 deletion have been found in populations of Finno-Ugric origin. We here report a high CCR5 delta32 frequency (15%) in another Finno-Ugric populations, the Estonians. The highest frequency (18%) was found on the geographically isolated Estonian island of Dagö. We examined 504 healthy unrelated individuals of Estonian nationality, whose grandparents were born in Estonia. The polymerase chain reaction assay was performed and the amplified products were digested with EcoRI.
Kalev
I
I
Department of Human Biology and Genetics, Institute of General and Molecular Pathology, University of Tartu, Estonia.
Mikelsaar
A V
AV
Beckman
L
L
Tasa
G
G
Pärlist
P
P
D001483:Base Sequence; D004957:Estonia; D005260:Female; D017353:Gene Deletion; D005787:Gene Frequency; D005828:Genetics, Population; D015658:HIV Infections / Q000235:genetics* / Q000517:prevention & control; D015497:HIV-1 / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011159:Population Surveillance; D019713:Receptors, CCR5 / Q000235:genetics*
D019713:Receptors, CCR5