Strategies for the systematic sequencing of complex genomes.
Recent spectacular advances in the technologies and strategies for DNA sequencing have profoundly accelerated the detailed analysis of genomes from myriad organisms. The past few years alone have seen the publication of near-complete or draft versions of the genome sequence of several well-studied, multicellular organisms - most notably, the human. As well as providing data of fundamental biological significance, these landmark accomplishments have yielded important strategic insights that are guiding current and future genome-sequencing projects.
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Genome Technology Branch and NIH Intramural Sequencing Center, National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland 20892, USA. egreen@nhgri.nih.gov
D000818:Animals; D022201:Chromosomes, Artificial; D016678:Genome; D006801:Humans; D020161:Physical Chromosome Mapping; D017422:Sequence Analysis, DNA / Q000379:methods*