title: Primary non-Hodgkin's lymphoma of the larynx (Stage IE) diagnosed by gene rearrangement.
abstract: An extremely rare case of primary non-Hodgkin's lymphoma of the larynx (Stage IE) diagnosed by gene rearrangement is reported. The patient was a 76-year-old man with a chief complaint of pharyngeal discomfort. Remission was obtained by excision of the tumour and radiotherapy. Surface phenotypic studies of the laryngeal lesion demonstrated a main population of B-cells expressing L-26, some of the atypical lymphocytes positive with UCHL-1. Genotypic analysis of the specimen disclosed a clonal rearrangement of the immunoglobulin heavy chain with the same rearrangement pattern. These data indicate that this patient had non-Hodgkin's lymphoma with diffuse large B-cell type. Gene rearrangement analysis was useful for diagnosis. Diagnostic and therapeutic options are discussed in light of the current literature.
authors.affiliation: Department of Otolaryngology, Yamagata University School of Medicine, Japan. noohta@med.id.yamagata-u.ac.jp
authors.forename: N
authors.initials: N
authors.lastname: Ohta
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Fukase
authors.forename: N
authors.initials: N
authors.lastname: Ksajima
authors.forename: M
authors.initials: M
authors.lastname: Aoyagi
mesh_terms: D000368:Aged; D005500:Follow-Up Studies; D015321:Gene Rearrangement; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000235:genetics; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000235:genetics; D016403:Lymphoma, Large B-Cell, Diffuse / Q000175:diagnosis* / Q000235:genetics; D008297:Male; D016133:Polymerase Chain Reaction