Adenosine: biphasic dose responses.
This article characterizes the occurrence of biphasic dose responses by adenosine and its stable analogs in numerous systems, including the respiratory tract, kidney, cardiovascular system, and brain. Considerable mechanistic research on various systems explored and clarified the interactions of the A-1 and A-2 receptors and their interactive influence on the occurrence of the biphasic dose responses. In general, the maximum stimulatory response was 2.5-fold or less than controls, while the stimulatory concentration range was quite variable ranging from 10- to 10(5)-fold.
Calabrese
E J
EJ
Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002320:Cardiovascular Physiological Phenomena / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006706:Homeostasis / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D018047:Receptors, Purinergic P1 / Q000502:physiology*; D012143:Respiratory Physiological Phenomena / Q000187:drug effects
D018047:Receptors, Purinergic P1; D000241:Adenosine