The effect of caffeic acid phenethyl ester on ischemia-reperfusion injury in comparison with alpha-tocopherol in rat kidneys.
Oxygen-derived free radicals have been implicated in the pathogenesis of renal injury after ischemia-reperfusion. Caffeic acid phenethyl ester (CAPE), an active component of propolis extract, exhibits antioxidant and anti-inflammatory properties. To determine whether CAPE offers any advantage over alpha-tocopherol, we compared their effects on an in vivo model of renal ischemia-reperfusion injury in rats. CAPE at 10 micromol/kg or alpha-tocopherol at 10 mg/kg was administered intraperitoneally before reperfusion. Acute administration of CAPE suppressed ischemia-reperfusion induced renal lipid peroxidation and tissue injury more than alpha-tocopherol. CAPE may therefore offer a therapeutic advantage in acute injury settings.
Irmak
M K
MK
Department of Biochemistry, Faculty of Medicine, Inonu University, Malatya, Turkey.
Koltuksuz
U
U
Kutlu
N O
NO
Yağmurca
M
M
Ozyurt
H
H
Karaman
A
A
Akyol
O
O
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002109:Caffeic Acids / Q000627:therapeutic use*; D005260:Female; D007668:Kidney / Q000098:blood supply*; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D014969:Xanthine Oxidase / Q000378:metabolism; D024502:alpha-Tocopherol / Q000627:therapeutic use*
D000975:Antioxidants; D002109:Caffeic Acids; D014969:Xanthine Oxidase; C055494:caffeic acid phenethyl ester; D024502:alpha-Tocopherol; D010626:Phenylethyl Alcohol