Cell migration/chemotaxis: biphasic dose responses.
The dose-dependent effects of chemoattractants on target cell migration such as tumor cells, fibroblasts, and especially neutrophils were assessed. In general, the dose-response characteristics were strikingly biphasic in nature and were independent of both the target tissue and chemoattractant agent. The assessment included evaluations of the quantitative features of the dose-response relationship, mechanistic foundations of the biphasic responsiveness and clinical applications.
Calabrese
E J
EJ
Department of Environmental Health Sciences, School of Public Health and Health Sciences, University of Massachusetts, Amherst 01003, USA. edwardc@schoolph.umass.edu
D000438:Alcohols / Q000494:pharmacology; D000818:Animals; D002465:Cell Movement / Q000187:drug effects*; D002633:Chemotaxis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000502:physiology; D005731:Ganglionic Stimulants / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000503:physiopathology; D009360:Neoplastic Cells, Circulating / Q000187:drug effects*; D020932:Nerve Growth Factor / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D009538:Nicotine / Q000494:pharmacology; D010431:Pentoxifylline / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D000515:alpha 1-Antitrypsin / Q000494:pharmacology
D000438:Alcohols; D005731:Ganglionic Stimulants; D010975:Platelet Aggregation Inhibitors; D010982:Platelet-Derived Growth Factor; D000515:alpha 1-Antitrypsin; D009538:Nicotine; D020932:Nerve Growth Factor; D010431:Pentoxifylline