Maternal transfer of melatonin alters the growth and sexual maturation of young Indian palm squirrel Funambulus pennanti.
To date, the phenomenon of maternal transfer of hormones to the young is an enigma. The present study explains for the first time the maternal transfer of melatonin (MEL) to the young, affecting neonatal growth and sexual maturation. The suckling pups of MEL-treated mothers exhibited significant decreases in body, testicular, vas deferens (male pups), ovarian and uterine (female pups) weights and increases in pineal gland activity along with high plasma MEL levels. The plasma level of testosterone decreased significantly in male pups, while estradiol increased and progesterone decreased in female pups of MEL-treated mothers. These results clearly suggest that MEL could be transported from the mothers to their young postnatally via the milk in order to influence neonatal growth and sexual maturation. Our results support the earlier concept and show for the first time that MEL can be transported from the mother to the young either prenatally through the placenta or postnatally via the milk. Therefore, maternal MEL can act as a biological signal for neonatal growth and sexual maturation.
Bishnupuri
K S
KS
Department of Zoology, Banaras Hindu University, Varanasi, India.
Haldar
C
C
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects; D005260:Female; D005865:Gestational Age; D012739:Gonadal Steroid Hormones / Q000097:blood; D006128:Growth / Q000187:drug effects*; D006130:Growth Disorders / Q000139:chemically induced*; D007774:Lactation; D008297:Male; D008431:Maternal-Fetal Exchange; D008550:Melatonin / Q000097:blood / Q000493:pharmacokinetics / Q000502:physiology* / Q000633:toxicity; D008892:Milk / Q000737:chemistry; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011628:Puberty, Delayed / Q000139:chemically induced*; D012589:Sciuridae; D012741:Sexual Maturation / Q000187:drug effects*
D012739:Gonadal Steroid Hormones; D008550:Melatonin