Lead accumulation in the mouse ovary after treatment-induced follicular atresia.
Although the main target of lead (Pb) toxicity is the red blood cell, Pb-associated changes in the nervous system, the kidney, and the reproductive system have also been described. The few Pb studies conducted on females revealed mostly miscarriages, premature delivery, and infant mortality in humans and animals. This study was done to correlate Pb accumulation in the ovary with damage to folliculogenesis. Pb burden was assayed by atomic absorption spectrometry in bone, liver, adrenal glands, ovary, and fetuses taken from mice exposed according to 2 protocols: intraperitoneal (i.p.) injection of Pb(NO(3))(2) 10 mg/kg/day for 15 days or 10 mg/kg/week for 15 weeks. Ovaries were examined histologically. Pb accumulation in the various soft tissues of acutely exposed mice was similar, and significantly higher than in the organs of chronically exposed mice. A low Pb concentration in the ovary caused dysfunction of folliculogenesis, with fewer primordial follicles and an increase in atretic antral follicles.
Taupeau
C
C
INSERM Unité 355, Maturation Gamétique et Fécondation 32, rue des Carnets, 92140-Clamart, France.
Poupon
J
J
Nomé
F
F
Lefèvre
B
B
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000378:metabolism; D005496:Follicular Atresia / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007854:Lead / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009566:Nitrates / Q000008:administration & dosage / Q000032:analysis / Q000493:pharmacokinetics* / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects / Q000378:metabolism* / Q000473:pathology; D011247:Pregnancy; D013054:Spectrophotometry, Atomic; D013977:Tibia / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D009566:Nitrates; D007854:Lead; C017461:lead nitrate; C031618:sodium nitrate