[Changes of inhibitory amino acid in the monkey frontal cortex during a figure recognition guided sequential movement task].
The levels of gamma-aminobutyric acid (GABA) and glycine (Gly) in the micro-dialysate from the monkey frontal cortex were measured by using the techniques of intracerebral microdialysis and high performance liquid chromatography with fluorescent detection while the animal was performing the Figure Recognition Motor Sequence (FRS) task. The probes were sited in the prefrontal cortex (PFC, 46 area), premotor cortex (PM, F7 and F2 areas) and primary motor cortex (MI, F1 area). The results showed that the level of GABA in PFC increased during the FRS task, whereas the level of Gly showed no significant changes.
Shen
L M
LM
Shanghai Institute of Brain Research, Chinese Academy of Sciences, Shanghai 200031.
Chen
Y C
YC
D000818:Animals; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D005998:Glycine / Q000378:metabolism*; D008253:Macaca mulatta; D017551:Microdialysis; D009043:Motor Activity / Q000502:physiology; D009068:Movement; D010364:Pattern Recognition, Visual / Q000502:physiology*; D017397:Prefrontal Cortex / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D005998:Glycine