title: The effect of bone marrow transplantation on systemic and oral health in Fanconi's aplastic anemia.
abstract: Fanconi's anemia (FA) is an autosomal-recessive disorder characterized by a progressive pancytopenia, diverse congenital abnormalities and increased predisposition to malignancy. Sixteen children with FA, aged between 4 to 16 were divided into two groups according to treatments. Nine children had bone marrow transplantation and seven children were treated with steroid and/or anapolan. The changes in dental caries, caries-associated microflora, salivary status and periodontal health were investigated in children with FA. Data were analyzed by one-way ANOVA. A statistically significant difference was found in hematological findings between children who have received bone marrow transplantation (BMT+) and the others, who have not received (BMT-). There was no significant difference in dental caries experience, salivary flow rate, buffering capacity, mutans streptococci and Lactobacilli levels between the study groups. A statistically significant difference was found in gingival index, plaque index, bleeding on probing, probing depth scores between the patients with FA in BMT(+) and BMT(-) groups (p<.05). In conclusion, besides systemic control, additional preventive measures during their whole life to maintain oral health is necessary in these children.
authors.affiliation: Department of Pediatric Hematology, Oncology, Istanbul University, Faculty of Medicine, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Yalman
authors.forename: E
authors.initials: E
authors.lastname: Sepet
authors.forename: G
authors.initials: G
authors.lastname: Aren
authors.forename: Z
authors.initials: Z
authors.lastname: Mete
authors.forename: G
authors.initials: G
authors.lastname: Külekçi
authors.forename: S
authors.initials: S
authors.lastname: Anak
mesh_terms: D000293:Adolescent; D000704:Analysis of Variance; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D015169:Colony Count, Microbial; D004245:DMF Index; D003731:Dental Caries / Q000209:etiology / Q000517:prevention & control; D003773:Dental Plaque / Q000209:etiology / Q000517:prevention & control; D003774:Dental Plaque Index; D005199:Fanconi Anemia / Q000097:blood / Q000150:complications / Q000628:therapy*; D005260:Female; D006801:Humans; D007778:Lactobacillus / Q000302:isolation & purification; D008297:Male; D009909:Oral Health; D010510:Periodontal Diseases / Q000209:etiology* / Q000517:prevention & control*; D010512:Periodontal Index; D012463:Saliva / Q000378:metabolism / Q000382:microbiology; D012636:Secretory Rate; D013295:Streptococcus mutans / Q000302:isolation & purification