Prevalence and family history of colorectal cancer: implications for screening.
OBJECTIVE
To estimate the current prevalence of family history and associated risk of prevalent colorectal cancer among middle aged and older British adults.


METHODS
Cross sectional analysis of colorectal cancer and self reported family history based on data from a large population based study in Norfolk, United Kingdom.


RESULTS
Of the 30,353 participants, 2,069 (6.8%) participants had reported a family history of colorectal cancer in at least one first degree relative. The prevalence of colorectal cancer in those with a family history was 1% and 0.5% in those without. Of the 151 participants with prevalent colorectal cancer, 14.6% reported a family history of the disease. Also, a family history of colorectal cancer in first degree relatives was significantly associated with an increased risk of prevalent colorectal cancer (multivariate odds ratio (OR) 2.32 (95% confidence interval (95% CI) 1.43 to 3.76). For those with one affected relative below the age of 45, and for those with two affected relatives the multivariate ORs were 5.29 (1.63 to 17.17) and 4.93 (1.17 to 20.70), respectively.


CONCLUSIONS
Although positive family history may identify a group with increased likelihood of colorectal cancer, screening strategies targeted solely at people with a family history will have limited impact on reducing mortality from colorectal cancer at the population level.
Sandhu
M S
MS
Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge School of Clinical Medicine, UK. manj.sandhu@srl.cam.ac.uk
Luben
R
R
Khaw
K T
KT
D000368:Aged; D015179:Colorectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010375:Pedigree; D015995:Prevalence; D006113:United Kingdom / Q000453:epidemiology