Hepatitis B and hepatitis C co-infection in patients with HIV.
HAART has increased the life expectancy of patients with HIV. However, as their life expectancy increases, it becomes increasingly important to focus on the management of concurrent illnesses such as chronic HBV and HCV infections which have the potential to increase mid to long term morbidity and mortality. Shared epidemiological risks have resulted in the HIV infected population having a higher incidence of both HBV and HCV than those uninfected with HIV. Co-infection with HIV modifies the natural history of HBV infection, increasing the rate of viral replication, risk of carriage and chronic hepatitis but without increasing liver necroinflammatory processes. In chronic HCV infection, the presence of HIV enhances the risk of severe liver disease. There is no evidence as yet that HBV directly impacts on HIV disease progression but HCV infection increases the risk of death or an AIDS defining illness and impairs CD4+ T cell recovery during antiretroviral therapy. Treatment of either hepatitis virus is complex because of pharmacokinetic interactions with components of HAART regimens.
Herrero Martínez
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Department of Virology and Haemophilia Centre, Royal Free and University College Medical School, London NW3 2PF, UK. E.Herrero@rfc.ucl.ac.uk
D023241:Antiretroviral Therapy, Highly Active; D004198:Disease Susceptibility; D018562:Disease Transmission, Infectious; D015658:HIV Infections / Q000150:complications* / Q000453:epidemiology / Q000276:immunology / Q000628:therapy; D016174:Hepacivirus / Q000472:pathogenicity / Q000502:physiology; D006509:Hepatitis B / Q000150:complications* / Q000453:epidemiology / Q000628:therapy / Q000635:transmission; D006515:Hepatitis B virus / Q000472:pathogenicity / Q000502:physiology; D006526:Hepatitis C / Q000150:complications* / Q000453:epidemiology / Q000628:therapy / Q000635:transmission; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000453:epidemiology / Q000821:virology