The adipocyte-secreted protein Acrp30 enhances hepatic insulin action.
Acrp30 is a circulating protein synthesized in adipose tissue. A single injection in mice of purified recombinant Acrp30 leads to a 2-3-fold elevation in circulating Acrp30 levels, which triggers a transient decrease in basal glucose levels. Similar treatment in ob/ob, NOD (non-obese diabetic) or streptozotocin-treated mice transiently abolishes hyperglycemia. This effect on glucose is not associated with an increase in insulin levels. Moreover, in isolated hepatocytes, Acrp30 increases the ability of sub-physiological levels of insulin to suppress glucose production. We thus propose that Acrp30 is a potent insulin enhancer linking adipose tissue and whole-body glucose metabolism.
Berg
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Department of Cell Biology, Albert Einstein College of Medicine, Bronx, New York, USA.
Combs
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Du
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Brownlee
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Scherer
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D017667:Adipocytes / Q000378:metabolism*; D052242:Adiponectin; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism / Q000502:physiology*; D002460:Cell Line; D002149:Energy Intake; D005947:Glucose / Q000096:biosynthesis; D006801:Humans; D007004:Hypoglycemic Agents / Q000494:pharmacology; D007328:Insulin / Q000502:physiology*; D036341:Intercellular Signaling Peptides and Proteins; D008099:Liver / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D011506:Proteins; D011994:Recombinant Proteins / Q000378:metabolism; D013844:Thiazoles / Q000494:pharmacology; D045162:Thiazolidinediones
D052242:Adiponectin; D001798:Blood Proteins; D007004:Hypoglycemic Agents; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D011994:Recombinant Proteins; D013844:Thiazoles; D045162:Thiazolidinediones; C089946:2,4-thiazolidinedione; D005947:Glucose