title: Association between HLA-A/-B antigens and -DRB1 alleles and nasopharyngeal carcinoma in Tunisia.
abstract: Using serologic and molecular methods, 45 nasopharyngeal carcinoma (NPC) patients were typed for HLA class I and class II and were compared to 100 unrelated normal Tunisians. Our results showed that the antigen frequency of HLA-B13 and allelic frequencies of DRB1*03, DRB1*15 were significantly higher in the NPC patients than in the control group (15.5 vs. 4; 26.4 vs. 11.5, and 14.4 vs. 6.5%, respectively) probably indicating a positive association with NPC. Moreover, we observed that HLA-A23 was absent in our NPC sample and was present in 18% of normal controls, and HLA-DRB1*11 was less frequent among the patients compared to the controls (5.5 vs. 14%) suggesting a protective effect of this association with NPC.
authors.affiliation: Institut de Carcinologie Salah Azaiz, Tunis, Tunisie. ridha.mokni@rns.tn
authors.forename: N
authors.initials: N
authors.lastname: Mokni-Baizig
authors.forename: K
authors.initials: K
authors.lastname: Ayed
authors.forename: F B
authors.initials: FB
authors.lastname: Ayed
authors.forename: S
authors.initials: S
authors.lastname: Ayed
authors.forename: F
authors.initials: F
authors.lastname: Sassi
authors.forename: A
authors.initials: A
authors.lastname: Ladgham
authors.forename: O
authors.initials: O
authors.lastname: Bel Hadj
authors.forename: A
authors.initials: A
authors.lastname: El May
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002277:Carcinoma / Q000453:epidemiology* / Q000276:immunology*; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D005260:Female; D005838:Genotype; D015234:HLA-A Antigens / Q000097:blood*; D015235:HLA-B Antigens / Q000097:blood*; D015798:HLA-DR1 Antigen / Q000097:blood*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000453:epidemiology* / Q000276:immunology*; D010641:Phenotype; D014416:Tunisia / Q000453:epidemiology
chemical_list: D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015798:HLA-DR1 Antigen