title: [Apoptosis, its mechanisms and medical significance. I. Definition of apoptosis and its progression at the cellular level].
abstract: Apoptosis is a one example of genetically-regulated cell death. It is characterized by the phylogenetically highly conserved activation of specific genes and proteins followed by energy-consuming proteolytic autodestruction. Apoptosis seems to be physiological and highly selective mechanism to eliminate either old or injured cells in organisms. It is in contrary to mitosis. A highly complex combination of various stimuli both extracellular and intracellular origins is required for induction of apoptosis together with preserved oxidative phosphorylation.
authors.affiliation: Ustav klinické imunologie a alergologie Lékarské fakulty UK Hradec Králové.
authors.forename: J
authors.initials: J
authors.lastname: Novosad
authors.forename: K
authors.initials: K
authors.lastname: Kodydková
authors.forename: J
authors.initials: J
authors.lastname: Krejsek
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D020169:Caspases / Q000502:physiology; D016923:Cell Death / Q000502:physiology; D006801:Humans; D008928:Mitochondria / Q000502:physiology; D009336:Necrosis; D015398:Signal Transduction
chemical_list: D020169:Caspases