Inflammation and remodeling in the adult and child with asthma.
Inflammation and remodeling are characteristic features of the conducting airways in asthma, but the relationships between inflammation, inappropriate remodeling, bronchial hyperresponsiveness, and reduced pulmonary function are still unclear. In both adults and children with asthma, there are structural changes of the conducting airways that include injury and loss of the surface epithelium, thickening of the reticular basement membrane, increases of underlying collagen, blood vessels, and airway smooth muscle, and plugging of the airways by exudate. Bronchial biopsies obtained from persons with mild stable asthma already demonstrate the presence of inflammation. Many of the inflammatory and structural changes begin early in childhood. Whereas corticosteroids markedly reduce many aspects of inflammation, it is not known whether and how they affect the changes associated with airway wall remodeling. Leukotriene receptor antagonists appear to be antiinflammatory and able to reduce the proliferation of bronchial smooth muscle.
Jeffery
P
P
Department of Gene Therapy, Imperial College School of Medicine, Royal Brompton Hospital, Sydney Street, London SW3 6NP, UK. p.jeffery@ic.ac.uk
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D001485:Basement Membrane / Q000473:pathology; D001980:Bronchi / Q000473:pathology*; D006801:Humans; D007249:Inflammation / Q000473:pathology; D020024:Leukotriene Antagonists / Q000627:therapeutic use; D009130:Muscle, Smooth / Q000473:pathology
D000305:Adrenal Cortex Hormones; D020024:Leukotriene Antagonists