Three patients with ophthalmoplegia associated with Campylobacter jejuni.
Cranial polyneuropathy is idiopathic in most patients. Idiopathic cranial polyneuropathy is an acute postinfectious syndrome, along with Guillain-Barré syndrome and Miller Fisher syndrome, in which the common preceding pathogen is Campylobacter jejuni. Serum anti-GQ1b antibodies are elevated in Miller Fisher syndrome and Guillain-Barré syndrome with ophthalmoplegia. Three patients with idiopathic cranial polyneuropathy with predominant ocular involvement are presented. C. jejuni isolated from stool specimens belonged to Penner serotypes O:4, O:23, and O:33. Serum anti-GQ1b antibodies were elevated in all patients but demonstrated rapid reduction concomitant with clinical recovery. All patients recovered completely. Because both preceding C. jejuni infection and elevated anti-GQ1b antibodies decreasing with time were seen in all patients, the pathogenesis of idiopathic cranial polyneuropathy with ophthalmoplegia may be similar to that of Miller Fisher syndrome.
Kuroki
S
S
Department of Pediatrics, Kobe City General Hospital, Kobe, Japan.
Saida
T
T
Nukina
M
M
Yoshioka
M
M
Seino
J
J
D000293:Adolescent; D000907:Antibodies, Bacterial / Q000097:blood; D002169:Campylobacter Infections / Q000150:complications* / Q000276:immunology / Q000382:microbiology; D016123:Campylobacter jejuni / Q000276:immunology / Q000302:isolation & purification*; D002648:Child; D002675:Child, Preschool; D003389:Cranial Nerve Diseases / Q000276:immunology / Q000382:microbiology*; D003967:Diarrhea / Q000382:microbiology; D004797:Enzyme-Linked Immunosorbent Assay; D005243:Feces / Q000382:microbiology; D006017:Glycolipids / Q000276:immunology; D006801:Humans; D008297:Male; D009802:Oculomotor Nerve / Q000276:immunology; D009886:Ophthalmoplegia / Q000382:microbiology*; D012075:Remission, Spontaneous
D000907:Antibodies, Bacterial; D006017:Glycolipids