Simple synthesis of condensed pyran containing compounds and their antimicrobial properties.
Reaction of various fused pyran compounds with formic acid was studied. Thus, refluxing 6-aminopyrano[2,3-c]pyrazole-5-carbonitriles 3 with formic acid afforded the corresponding 3-aryl-3-(5-hydroxy-3-methyl-1H-pyrazole-4-yl)propanoic acids 4. Whereas, reaction of formic acid with 2-amino-4H-1-benzopyran-3-carbonitriles 6 gave the corresponding quinoline-2,5(1H,6H)-diones 7. The study was also extended towards many spiro compounds possessing pyran residue. The antimicrobial properties of the prepared compounds was screened.
Mishriky
N
N
National Research Centre, Dokki, Cairo, Egypt.
Girgis
A S
AS
Asaad
F M
FM
Ibrahim
Y A
YA
Sobieh
U I
UI
Fawzy
N G
NG
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005561:Formates / Q000737:chemistry; D005658:Fungi / Q000187:drug effects; D007202:Indicators and Reagents; D008826:Microbial Sensitivity Tests; D011714:Pyrans / Q000138:chemical synthesis* / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D005561:Formates; D007202:Indicators and Reagents; D011714:Pyrans; C030544:formic acid