Antimetastasis gene expression and numerical chromosomal abnormalities of chromosomes 1 & 17 in serous tumours of the ovary.
OBJECTIVE
The aim of this study was to examine the expression of the antimetastasis gene nm23 and numerical changes on chromosome 1 and 17 in ovarian tumours.


METHODS
In this study 20 serous cystadenocarcinomas, ten borderline and five benign tumours were analysed for expression of the nm23 antimetastasis gene by immunohistochemistry and for numerical chromosomal abnormalities of chromosomes 1 and 17 by interphase cytogenetics.


RESULTS
Strong intracytoplasmic immunoreactivity with the antimetastasis gene was observed in late stage carcinomas but not in benign or borderline tumours or in lymph node metastases. Numerical abnormalities were only observed in carcinomas.


CONCLUSIONS
These sets of data are consistent with the majority of benign and borderline tumours lacking invasive potential. Odds Ratio (OR) assessment indicates that the presence of numerical aberrations correlates with immunopositivity.
Kaya
H
H
Marmara University, School of Medicine, Department of Pathology, Istanbul, Turkey.
Evans
M F
MF
Ekicioglu
G
G
Tuzlali
S
S
Küllü
S
S
Foster
C
C
D000704:Analysis of Variance; D014408:Biomarkers, Tumor / Q000032:analysis; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002886:Chromosomes, Human, Pair 17; D003536:Cystadenocarcinoma / Q000737:chemistry / Q000235:genetics* / Q000473:pathology*; D020732:Cytogenetic Analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D020559:Monomeric GTP-Binding Proteins / Q000032:analysis; D054778:NM23 Nucleoside Diphosphate Kinases; D009701:Nucleoside-Diphosphate Kinase; D016017:Odds Ratio; D010051:Ovarian Neoplasms / Q000737:chemistry / Q000235:genetics* / Q000473:pathology*; D018709:Statistics, Nonparametric; D014157:Transcription Factors / Q000032:analysis; D014421:Turkey
D014408:Biomarkers, Tumor; D054778:NM23 Nucleoside Diphosphate Kinases; D014157:Transcription Factors; C517938:NME1 protein, human; D009701:Nucleoside-Diphosphate Kinase; D020559:Monomeric GTP-Binding Proteins