Th1/Th2 effector choice in parasitic infection: decision making by committee.
Parasitic infections frequently result in highly polarized CD4+ T cell responses characterized by dominant Th1 or Th2 cytokine production profiles. Although previously thought to be strictly dependent on signaling by the differentiative cytokines, IL-12 and IL-4, recent data indicate that this polarization may be primarily decided instead by a series of different factors intrinsic to the pathogen-antigen-presenting-cell interaction that influence T cell priming.
Jankovic
D
D
Immunobiology Section, Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892-0425, USA. djankovic@niaid.nih.gov
Sher
A
A
Yap
G
G
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis; D015847:Interleukin-4 / Q000096:biosynthesis; D008954:Models, Biological; D010272:Parasitic Diseases / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000378:metabolism; D015398:Signal Transduction; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D011948:Receptors, Antigen, T-Cell; D018664:Interleukin-12; D015847:Interleukin-4