title: Novel sesquiterpenoids from the roots of Phyllanthus emblica.
abstract: Three novel bisabolane-type sesquiterpenoids, phyllaemblic acids B (1) and C (2) and phyllaemblicin D (3), together with two new phenolic glycosides, 2-carboxylmethylphenol 1-O-beta-D-glucopyranoside (4) and 2,6-dimethoxy-4-(2-hydroxyethyl)phenol 1-O-beta-D-glucopyranoside (5), were isolated from the roots of Phyllanthus emblica. The structures of 1-5 were established by spectral and chemical methods. The absolute stereochemistry of 1 and 2 was determined by applying the PGME method.
authors.affiliation: Faculty of Pharmaceutical Sciences, Nagasaki University, Bunkyo-Machi 1-14, Nagasaki 852-8521, Japan.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Zhang
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: C R
authors.initials: CR
authors.lastname: Yang
authors.forename: I
authors.initials: I
authors.lastname: Kouno
mesh_terms: D019665:Euphorbiaceae / Q000737:chemistry*; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D008968:Molecular Conformation; D015394:Molecular Structure; D008517:Phytotherapy; D018517:Plant Roots / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification*; D013329:Structure-Activity Relationship
chemical_list: C435254:2,6-dimethoxy-4-(2-hydroxyethyl)phenol 1-O-glucopyranoside; C435253:2-carboxylmethylphenol 1-O-glucopyranoside; D005960:Glucosides; D012717:Sesquiterpenes; C435250:phyllaemblic acid B; C435251:phyllaemblic acid C; C435252:phyllaemblicin D