title: Epidemiology of progressive supranuclear palsy. ESGAP Consortium. European Study Group on Atypical Parkinsonisms.
abstract: Progressive supranuclear palsy (PSP) is a rare form of parkinsonism. The incidence rates are about 0.3-1.1 cases per 100,000 persons. The only two case-control studies performed up to now show conflictual results as regards education and residence in rural areas. Recently, a cluster of PSP and atypical parkinsonism has been observed in French Antilles. The hypothesis is that a consumption of both tropical fruit and herbal tea may be associated with PSP onset. Some PSP families with a probably autosomal dominant transmission have been described. A high frequency of a tau haplotype (H1/H1) associated with PSP is reported by some authors. The significance of this association is still not clear. We have performed a case-control study on 58 PSP cases, 116 hospital controls and 58 population controls.
authors.affiliation: Department of Neurological Sciences, La Sapienza University, Rome, Italy.
authors.forename: N
authors.initials: N
authors.lastname: Vanacore
authors.forename: V
authors.initials: V
authors.lastname: Bonifati
authors.forename: C
authors.initials: C
authors.lastname: Colosimo
authors.forename: G
authors.initials: G
authors.lastname: Fabbrini
authors.forename: G
authors.initials: G
authors.lastname: De Michele
authors.forename: R
authors.initials: R
authors.lastname: Marconi
authors.forename: D
authors.initials: D
authors.lastname: Nicholl
authors.forename: N
authors.initials: N
authors.lastname: Locuratolo
authors.forename: S
authors.initials: S
authors.lastname: Romano
authors.forename: G
authors.initials: G
authors.lastname: Talarico
authors.forename: F
authors.initials: F
authors.lastname: Stocchi
authors.forename: U
authors.initials: U
authors.lastname: Bonuccelli
authors.forename: P
authors.initials: P
authors.lastname: Lamberti
authors.forename: P
authors.initials: P
authors.lastname: Vieregge
authors.forename: G
authors.initials: G
authors.lastname: Meco
mesh_terms: D017668:Age of Onset; D001628:Beverages / Q000009:adverse effects; D004781:Environmental Exposure; D005260:Female; D005820:Genetic Testing; D019430:Guadeloupe / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D008297:Male; D009154:Mutation / Q000235:genetics; D009784:Occupational Diseases / Q000453:epidemiology; D015995:Prevalence; D012307:Risk Factors; D012737:Sex Factors; D013494:Supranuclear Palsy, Progressive / Q000453:epidemiology* / Q000503:physiopathology; D016875:tau Proteins / Q000235:genetics
chemical_list: D016875:tau Proteins