Enhanced behavioral recovery from sensorimotor cortex lesions after pyramidotomy in adult rats.
Unilateral transection of the bulbar pyramid, performed before the ablation of the ipsilateral sensorimotor cortex, has been shown to facilitate the recovery of operantly conditioned reflexes and compensatory processes in rats. Such enhanced behavioral recovery was absent when only the sensorimotor cortex was ablated. This phenomenon is explained by the switching of motor activity under the control of the cortico-rubrospinal system. Switching of the descending influences is accomplished through the following loop: cortico-rubral projection-red nucleus-inferior olive-cerebellum-thalamus-cerebral cortex. This suggests that a preliminary lesion of the peripheral part of the system, represented by a descending spinal projection, facilitates the recovery processes to develop during the subsequent destruction of its central part.
Fanardjian
V V
VV
L.A. Orbeli Institute of Physiology, National Academy of Sciences of Armenia, 22 Orbeli Bros. Str., 375028, Yerevan, Republic of Armenia. fanardjian@neuroscience.am
Gevorkyan
O V
OV
Mallina
R K
RK
Melik-Moussian
A B
AB
Meliksetyan
I B
IB
D000818:Animals; D001921:Brain / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D002540:Cerebral Cortex / Q000502:physiology*; D003216:Conditioning, Operant / Q000502:physiology; D007839:Functional Laterality; D005684:Gait; D008526:Medulla Oblongata / Q000502:physiology; D008959:Models, Neurological; D009043:Motor Activity / Q000502:physiology*; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009847:Olivary Nucleus / Q000502:physiology; D010243:Paralysis; D011712:Pyramidal Tracts / Q000502:physiology*; D051381:Rats; D012012:Red Nucleus / Q000502:physiology; D013003:Somatosensory Cortex / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*