[Antigenicity and phototoxicity of water-soluble extract from Salacia reticulata (Celastraceae)].
The antigenicity and phototoxicity of water-soluble extract from Salacia reticulata (SRE) were examined in guinea pigs. In a study of active systemic anaphylaxis reaction, neither the oral administration group (64 or 320 mg/kg, 5 times/week, 3 weeks) nor the subcutaneous administration group (64 mg/kg, 1 time/week, 3 weeks) exhibited any anaphylactic reaction. Moreover, sensitization with serum obtained from these animals did not induce passive cutaneous anaphylaxis reaction in normal animals. In a phototoxicity study, oral administration of SRE (320 mg/kg) induced neither erythema nor edema. These results suggest that SRE is not antigenic or phototoxic.
Shimoda
H
H
Morishita Jintan Co. Ltd.: 1-1-30, Tamatsukuri, Chuo-ku, Osaka 540-8566, Japan.
Asano
I
I
Yamada
Y
Y
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D017484:Dermatitis, Phototoxic / Q000276:immunology*; D000939:Epitopes; D006168:Guinea Pigs; D008297:Male; D010936:Plant Extracts / Q000276:immunology / Q000633:toxicity; D010946:Plants, Medicinal / Q000737:chemistry*; D019685:Rosales / Q000378:metabolism*; D012995:Solubility; D014867:Water
D000939:Epitopes; D010936:Plant Extracts; D014867:Water