title: [Use of plasmapheresis for correction of metabolic disorders in patients with surgical sepsis].
abstract: Twenty-four patients aged 16-67 years with surgical sepsis developing as a result of pancreonecrosis, gynecological diseases, urological sepsis. closed abdominal injury, and suppurative inflammation of soft tissues were examined. Endotoxemia caused pronounced disorders in metabolism, particularly purine metabolism, and the associated lipid peroxidation processes. Plasmapheresis exerted a positive effect in patients with high concentration of medium molecular-weight polypeptides (more than 0.32 arb. units) in the blood, decreasing the mortality by 40.5%. At lower concentrations of these polypeptides in the blood (less than 0.32 arb. units) plasmapheresis is inefficient.
authors.forename: A B
authors.initials: AB
authors.lastname: Tolkach
authors.forename: V T
authors.initials: VT
authors.lastname: Dolgikh
authors.forename: B A
authors.initials: BA
authors.lastname: Reĭs
authors.forename: L G
authors.initials: LG
authors.lastname: Shikunova
authors.forename: V D
authors.initials: VD
authors.lastname: Konvaĭ
authors.forename: A G
authors.initials: AG
authors.lastname: Malykhin
authors.forename: L I
authors.initials: LI
authors.lastname: Ktinidi
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D019446:Endotoxemia / Q000097:blood / Q000378:metabolism / Q000628:therapy; D005260:Female; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood; D010956:Plasmapheresis; D011182:Postoperative Care; D011687:Purines / Q000378:metabolism; D018805:Sepsis / Q000097:blood / Q000378:metabolism / Q000401:mortality / Q000628:therapy*; D013514:Surgical Procedures, Operative
chemical_list: D010455:Peptides; D011687:Purines