[Change of hymodynamics and circulating endothelial cells in chronic obstructive pulmonary diseases (COPD) and cor pulmonale patients].
OBJECTIVE
To investigate the vascular endothelial injuries by observing the changes of circulating endothelial cells (CEC) numbers in blood and hemodynamics in COPD and cor pulmonale patients.


METHODS
The arterial catheterion technique and CEC collection technique were used, superoxide dismutase (SOD) and malondialdyhyde(MDA) levels were determined respectively.


RESULTS
mPAP (3.76 +/- 0.75 kPa) and CEC (16.70 +/- 2.65/0.9 microliter), MDA (6.98 +/- 1.47 mumol/L) in the chronic cor pulmonale are higher than that of mPAP (2.09 +/- 0.41 kPa) and CEC (8.48 +/- 2.23 microliters) in COPD, the numbers of CEC are adversely correlated to PaO2 (gamma = 0.9423, P < 0.001) and positively correlated with mPAP (gamma = 0.8270, P < 0.001), superoxide dismutase(SOD) was decreased.


CONCLUSIONS
mPAP, CEC are higher in cor pulmonale than that in COPD, CEC numbers rise when the PaO2 was lowered, hypoxia may worsen the vascular endothelial injuries.
Peng
W
W
General Hospital Commission of Science Technology and Industry of National Defence, Beijing 100101.
Zou
X
X
Mao
B
B
D000328:Adult; D000368:Aged; D002452:Cell Count; D004730:Endothelium, Vascular / Q000473:pathology*; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000473:pathology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000473:pathology / Q000503:physiopathology