title: Multiple minute carcinoids in type A gastritis: attempt at 3-D reconstruction.
abstract: In type A gastritis, the numbers of endocrine cell micronests (ECM) and carcinoids increase through the trophic action of gastrin. This study examined the characteristics and growth of carcinoids in type A gastritis. A total of 395 lesions in five surgically removed stomachs with type A gastritis were investigated, in terms of number, size, distribution and histological appearance, to clarify the tumorigenesis and progression of carcinoids. 3-D reconstruction using serial paraffin sections was used to study carcinoid progression. Our findings suggest that in type A gastritis, carcinoids arise in areas where minute carcinoids are present at a high density. They also suggest that early stage carcinoids not only become large expansively, but also develop in a very complex manner, by maintaining contact with surrounding minute carcinoids.
authors.affiliation: Department of Pathology, Jikei University School of Medicine, Tokyo, Japan. tac8@jikei.ac.jp
authors.forename: T
authors.initials: T
authors.lastname: Nojiri
authors.forename: M
authors.initials: M
authors.lastname: Ikegami
mesh_terms: D000328:Adult; D002276:Carcinoid Tumor / Q000145:classification / Q000150:complications / Q000473:pathology* / Q000601:surgery; D019858:Enteroendocrine Cells / Q000473:pathology*; D005260:Female; D005757:Gastritis, Atrophic / Q000150:complications / Q000473:pathology* / Q000601:surgery; D006801:Humans; D021621:Imaging, Three-Dimensional; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000150:complications / Q000473:pathology* / Q000601:surgery