[Analysis of apoptosis in premalignant and malignant epithelia of buccal mucosa].
To determine the relationship between apoptosis and carcinogenesis of oral mucosa, the distribution patterns of apoptosis in normal (N), inflammation (IF), dysplasia (DYS) and squamous cell carcinoma (SCC) of oral mucosa were evaluated by in situ end-labeling method. Results showed that the apoptosis levels in N and IF were relatively lower and stable, whereas the apoptosis of DYS was the highest one in all observed groups. The apoptosis of DYS and SCC were increased obviously higher than N and IF. The results indicated that apoptosis played an important role in premalignant lesion and malignancy of oral mucosa.
Jin
Y
Y
Department of Oral Pathology, Qindu Stomatological College, the Fourth Military Medical University.
Deng
Z
Z
D017209:Apoptosis; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D006801:Humans; D009061:Mouth Mucosa / Q000166:cytology* / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology*; D011230:Precancerous Conditions / Q000473:pathology*; D013280:Stomatitis / Q000473:pathology