The effect of galanin on wide-dynamic range neuron activity in the spinal dorsal horn of rats.
The present study investigated the effect of galanin on wide-dynamic range (WDR) neuron activity in the dorsal horn of the spinal cord of rats. The evoked discharge of WDR neurons was elicited by transdermic electrical stimulation applied on the ipsilateral hindpaw of rats. Galanin was administered directly on the spinal dorsal surface of L3-L5. The evoked discharge frequency of the WDR neurons decreased significantly after the administration of galanin and the effect lasted for more than 30 min. Furthermore, the inhibitory effect of galanin on the evoked discharge frequency of WDR neurons was blocked by following administration of the galanin antagonist galantide, indicating that the inhibitory effect of galanin on the activity of WDR neurons was induced by activating galanin receptors in the dorsal horn of the spinal cord. The results suggest that galanin has an inhibitory role in the transmission of presumed nociceptive information in the dorsal horn of the spinal cord in rats.
Yu
L C
LC
Department of Physiology, College of Life Sciences, and National Laboratory of Biomembrane and Membrane Biotechnology, Peking University, 100871, Beijing, People's Republic of China. yulc@pku.edu.cn
Xu
S L
SL
Xiong
W
W
Lundeberg
T
T
D000818:Animals; D004558:Electric Stimulation; D005071:Evoked Potentials; D019004:Galanin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006614:Hindlimb / Q000294:innervation; D007278:Injections, Spinal; D008297:Male; D008839:Microelectrodes; D020671:Posterior Horn Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013373:Substance P / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
C074975:galantide; D013373:Substance P; D019004:Galanin