The state of leukocyte adhesiveness/aggregation in the peripheral blood of patients with type 2 diabetes and ischemic vascular disease.
White blood cells have a potential role in the pathogenesis of vasculopathy in diabetic patients. We studied the circulating peripheral blood in a cohort of patients with documented ischemic heart or brain disease with and without type 2 diabetes by means of image analysis and flow cytometry. Our study showed that the state of leukocyte adhesiveness/aggregation is slightly increased in those who had concomitant diabetes but that there was no difference regarding the expression of CD11b/CD18 and CD62L antigens on the surface of the peripheral blood white blood cells. The finding of a significantly increased number of white blood cells in the peripheral blood of patients with ischemic vascular diseases is important insofar as it is associated with a poorer prognosis.
Fusman
R
R
Department of Internal Medicine D, Tel-Aviv Sourasky Medical Center, Ichilov Hospital, Israel.
Rotstein
R
R
Zeltser
D
D
Prochorov
V
V
Shapira
I
I
Bornstein
N M
NM
Keren
G
G
Roth
A
A
Miller
H I
HI
Avitzour
D
D
Arber
N
N
Berliner
S
S
D000368:Aged; D002545:Brain Ischemia / Q000097:blood / Q000150:complications; D018845:CD11 Antigens / Q000097:blood; D018821:CD18 Antigens / Q000097:blood; D002448:Cell Adhesion; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D005260:Female; D006801:Humans; D007511:Ischemia / Q000097:blood* / Q000150:complications; D019041:L-Selectin / Q000097:blood; D007962:Leukocytes / Q000276:immunology / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000150:complications; D011379:Prognosis
D018845:CD11 Antigens; D018821:CD18 Antigens; D019041:L-Selectin