[Detection of antineutrophil cytoplasmic autoantibodies in pregnancy induced hypertension and its clinical significance].
OBJECTIVE
To explore the level of antineutrophil cytoplasmic autoantibodies (ANCA) in patients with pregnancy induced hypertension (PIH) and its clinical significance.


METHODS
37 cases with PIH and 39 non-PIH pregnancy were studied for ANCA by indirect immunflourscence.


RESULTS
ANCA positive rates were 33.3%, 88.9% and 86.4% in mild, moderate, severe PIH, respectively, and most of them were c-ANCA. The positive rate was only 13.2% in non-PIH control, significantly lower than those in PIH (P < 0.001).


CONCLUSIONS
ANCA may be one of the causes for endothelial cell damage and a predicting marker in PIH.
Zhao
W
W
Research and Training Center in Women's and Children's Health, First Affiliated Hospital, Beijing Medical University, Beijing 100034.
Chen
L
L
Wang
L
L
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic / Q000097:blood*; D005260:Female; D006801:Humans; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy
D019268:Antibodies, Antineutrophil Cytoplasmic