The role of troponin abnormalities as a cause for stunned myocardium.
Myocardial stunning is a form of ischemic injury, which occurs with transient ischemia followed by re-establishment of flow, and which results in reversible cardiac dysfunction. There is evidence that the molecular defect in stunning is at the level of the contractile apparatus. Selective proteolysis of the myofilament protein, troponin I, appears to underlie the phenotype of stunning in some models, but other myofilament protein modifications may also have a role.
Van Eyk
J E
JE
Department of Biochemistry, Queen's University, Kingston, Canada. JVE1@post.queensu.ca
Murphy
A M
AM
D008841:Actin Cytoskeleton / Q000502:physiology; D000818:Animals; D006801:Humans; D051379:Mice; D009200:Myocardial Contraction / Q000502:physiology; D017682:Myocardial Stunning / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000502:physiology*; D051381:Rats; D014336:Troponin / Q000378:metabolism*
D014336:Troponin