title: Nitric oxide modulates spontaneous cord dorsum potentials in the cat spinal cord.
abstract: A previous study has shown that lumbar spontaneous cord dorsum potentials (CDPs) are produced by background activity of a neuronal ensemble located in the dorsal horn. Here, the effects produced by intravenous application of the nitric oxide synthase inhibitor L-N(G)-nitro arginine (L-NOARG, 100 microg/kg) and of the nitric oxide donor 3-morpholinosydnonimine hydrochloride (SIN-1, 500 microg/kg) on spontaneous CDPs were examined. Experiments were performed on pentobarbitally anesthetized, paralyzed and spinalized cats. The amplitude of spontaneous CDPs increased after L-NOARG, however, decreased after SIN-1. These observations suggest that electrical activity of dorsal horn neurones generating spontaneous CDPs is dependent on nitric oxide production.
authors.affiliation: Instituto de Fisiología, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico.
authors.forename: E
authors.initials: E
authors.lastname: Manjarrez
authors.forename: T
authors.initials: T
authors.lastname: Rocha
authors.forename: G
authors.initials: G
authors.lastname: Rojas-Piloni
authors.forename: I
authors.initials: I
authors.lastname: Méndez
authors.forename: A
authors.initials: A
authors.lastname: Flores
mesh_terms: D000200:Action Potentials / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D002415:Cats; D004791:Enzyme Inhibitors / Q000494:pharmacology; D008981:Molsidomine / Q000031:analogs & derivatives / Q000494:pharmacology; D019331:NG-Nitroarginine Methyl Ester / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects / Q000502:physiology; D009434:Neural Pathways / Q000187:drug effects / Q000201:enzymology*; D009569:Nitric Oxide / Q000819:agonists / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D020030:Nitric Oxide Donors / Q000494:pharmacology; D019001:Nitric Oxide Synthase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D020671:Posterior Horn Cells / Q000187:drug effects / Q000201:enzymology*
chemical_list: D004791:Enzyme Inhibitors; D020030:Nitric Oxide Donors; D009569:Nitric Oxide; C002385:linsidomine; D008981:Molsidomine; D019001:Nitric Oxide Synthase; D019331:NG-Nitroarginine Methyl Ester