title: K-ras Gene Mutations in Liver Carcinomas from a Mediterranean Area of Spain.
abstract: The prevalence of human liver cancer shows a broad spectrum of variation in distinct geographical regions, depending on different risk factors, and their pathogenesis is poorly understood. We study the significance of molecular alterations of K-ras gene in human liver carcinomas in a low-incidence region such as a Mediterranean area of Spain (Valencia and Gerona). Our results reveal a low incidence of K-ras codon 12 mutations in hepatocellular carcinomas (HCC) and a higher incidence in cholangiocarcinomas (CCC). Similar results have been obtained in high-risk areas. We conclude that K-ras gene mutations are not a major event in the malignant transformation of hepatic cells in this region of the Mediterranean but that molecular implications of hepatocellular and cholangiocarcinomas appear to be different. Int J Surg Pathol 8(4):267-270, 2000
authors.affiliation: Department of Pathology, Facultad de Medicina y Odontología, Valencia.
authors.forename: Javier
authors.initials: J
authors.lastname: Boix-Ferrero
authors.forename: Antonio
authors.initials: A
authors.lastname: Pellín
authors.forename: José Rafael
authors.initials: JR
authors.lastname: Blesa
authors.forename: Manuel
authors.initials: M
authors.lastname: Adrados
authors.forename: Antonio
authors.initials: A
authors.lastname: Llombart-Bosch