title: Peripheral bone metastasis from hepatocellular carcinoma: sonographic findings.
abstract: METHODS
  We reviewed medical and radiologic records of five patients with bone metastasis from hepatocellular carcinoma (HCC) to evaluate the role of sonography (US) in the diagnosis of this bone metastasis.
  
  
  RESULTS
  The metastatic lesions were clearly visualized by US as expansive, homogeneous, soft tissue masses with bony destruction, and color Doppler US showed fine vessels within the lesions. After treatment, US showed a decrease in tumor size with an increase in echogenicity and a decrease in blood flow. Hepatic US at the time of bone metastasis showed a portal tumor thrombus in all cases.
  
  
  CONCLUSIONS
  When US detects a portal venous tumor thrombus in HCC patients, attention should be directed not only to the liver but also to bone to improve patient care. US is useful not only in detecting the metastatic lesion but also in evaluating the treatment effect.
authors.affiliation: First Department of Internal Medicine, Akita University School of Medicine, 1-1-1 Hondo, Akita City, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Sato
authors.forename: H
authors.initials: H
authors.lastname: Ishida
authors.forename: K
authors.initials: K
authors.lastname: Konno
authors.forename: Y
authors.initials: Y
authors.lastname: Hamashima
authors.forename: H
authors.initials: H
authors.lastname: Naganuma
authors.forename: T
authors.initials: T
authors.lastname: Komatsuda
authors.forename: K
authors.initials: K
authors.lastname: Nakane
authors.forename: N
authors.initials: N
authors.lastname: Yamada
authors.forename: J
authors.initials: J
authors.lastname: Ishida
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary*; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging* / Q000556:secondary*; D005260:Female; D006801:Humans; D008113:Liver Neoplasms; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D018615:Ultrasonography, Doppler, Color