title: Fluvoxamine in the treatment of panic disorder: a multi-center, double-blind, placebo-controlled study in outpatients.
abstract: Serotonergic mechanisms have been implicated in panic disorder, and several preliminary studies suggest that fluvoxamine, a selective serotonin reuptake inhibitor (SSRI), is helpful in its treatment. This 8-week double-blind parallel-group study compared fluvoxamine with a placebo in 188 patients with DSM-III-R defined panic disorder with or without agoraphobia. Efficacy assessments included a Daily Panic Attack Inventory, the Sheehan Disability Scale, the Clinical Anxiety Scale and the Clinical Global Impression Scale. When compared with the placebo, fluvoxamine produced highly significant improvements in most measures of the frequency and severity of panic disorder and in the more global aspects of disability and distress. Significant improvement was evident as early as week 1 for some panic variables. Fluvoxamine is a potent anti-panic agent with a relatively rapid onset of action.
authors.affiliation: Department of Psychiatry, Albert Einstein College of Medicine, Montefiore Medical Center, 111 E. 210th Street, Bronx, New York, NY 10467-2490, USA. asnisarts@aol.com
authors.forename: G M
authors.initials: GM
authors.lastname: Asnis
authors.forename: F A
authors.initials: FA
authors.lastname: Hameedi
authors.forename: A W
authors.initials: AW
authors.lastname: Goddard
authors.forename: S G
authors.initials: SG
authors.lastname: Potkin
authors.forename: D
authors.initials: D
authors.lastname: Black
authors.forename: M
authors.initials: M
authors.lastname: Jameel
authors.forename: K
authors.initials: K
authors.lastname: Desagani
authors.forename: S W
authors.initials: SW
authors.lastname: Woods
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D004311:Double-Blind Method; D005260:Female; D016666:Fluvoxamine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016584:Panic Disorder / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D011446:Prospective Studies; D011569:Psychiatric Status Rating Scales; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D016666:Fluvoxamine; D017367:Selective Serotonin Reuptake Inhibitors