title: Antiproliferative effect of isopentenylated coumarins on several cancer cell lines.
abstract: 33 coumarins, mainly the simple isopentenylated coumarins and derived pyrano- and furanocoumarins, were examined for their antiproliferative activity towards several cancer and normal human cell lines. The pyrano- and furanocoumarins showed strong activity against the cancer cell lines, whereas they had weak antiproliferative activity against the normal human cell lines. The decreasing rank order of potency was osthenone (10), clausarin (25), clausenidin (26), dentatin (24), nordentatin (23), imperatorin (29), seselin (27), xanthyletin (21), suberosin (17), phebalosin (8) and osthol (12). The structure-activity relationship established from the results revealed that the 1,1-dimethylallyl and isopentenyl groups have an important role for antiproliferative activity.
authors.affiliation: Laboratory of Bio-organic Chemistry, Tokyo Denki University, Hatoyama, Saitama, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kawaii
authors.forename: Y
authors.initials: Y
authors.lastname: Tomono
authors.forename: K
authors.initials: K
authors.lastname: Ogawa
authors.forename: M
authors.initials: M
authors.lastname: Sugiura
authors.forename: M
authors.initials: M
authors.lastname: Yano
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: C
authors.initials: C
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Furukawa
mesh_terms: D000970:Antineoplastic Agents / Q000737:chemistry / Q000494:pharmacology*; D002455:Cell Division; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008956:Models, Chemical; D009369:Neoplasms / Q000188:drug therapy*; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D003374:Coumarins; C030123:coumarin