[Effect of kidney yin-yang replenishing Chinese herbs on the binding character of insulin receptor on hepatocyte membrane in androgen-induced sterility rats].
OBJECTIVE
To observe the effect of Kidney Yin-Yang replenishing Chinese herbs on the binding character of insulin receptor (IR) on hepatocyte membrane from androgen-induced sterility rats (ASR).


METHODS
The number and affinity of IR on hepatocyte membrane of ASR were determined with radioligand binding assay.


RESULTS
There was no significant difference of the number or affinity for both high and low affinity sites of IR between normal and ASR.


CONCLUSIONS
The treatment with Kidney Yin-Yang replenishing Chinese herbs had no effect on insulin binding although a relatively high rate of ovulation induction on ASR was observed.
Li
G
G
Obstetric and Gynecologic Hospital of Shanghai Medical University, Shanghai 200011.
Gui
S
S
Tang
Y
Y
D000818:Animals; D001665:Binding Sites; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D007247:Infertility, Female / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011972:Receptor, Insulin / Q000378:metabolism*; D013739:Testosterone
D004365:Drugs, Chinese Herbal; D013739:Testosterone; D011972:Receptor, Insulin