[Dynamic distribution in vivo of TIL from human tongue cancer after local injection in animal model].
On the basis of established nude mice transplanted tumor model of human tongue squamous cell carcinoma, peritumor injection was performed with 3H-TdR labeled TIL from human tongue cancer after 4 weeks culture. The dynamic distribution of 3H-TIL in vivo was learned through detecting the radioactivity of the target tissues. The results demonstrated that 3H-TIL was found in the whole body. There were about 2.1-30 times more in tumor tissues than in normal tissues and 3H-TILs even collected in the tumor tissues distal to the injective sites. The nearer to the injective sites the tumor tissues, the more 3H-TIL collected. It showed that local injection of TIL could be expected to exert a better antitumor effect.
Liao
G
G
Department of Oral & Maxillofacial Surgery, College of Stomatology.
Mao
Z
Z
Xu
P
P
D000328:Adult; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000628:therapy*; D006801:Humans; D016219:Immunotherapy, Adoptive; D016246:Lymphocytes, Tumor-Infiltrating / Q000637:transplantation*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014062:Tongue Neoplasms / Q000473:pathology / Q000628:therapy*