title: Cytochrome oxidase activity in the olfactory system of staggerer mutant mice.
abstract: The staggerer mutation is characterized by the disruption of a single recessive gene encoding for the nuclear hormone receptor RORalpha. In addition to the well-studied gene expression in the cerebellum causing massive primary Purkinje cell loss, the RORalpha gene is also expressed in the thalamus and the olfactory bulb. A quantitative histochemical study of cytochrome oxidase activity was performed in staggerer mutants and their respective controls in order to determine whether olfactory bulb neuropathology leads to neuronal metabolic alterations in olfactory and related limbic regions. In the staggerer olfactory bulb, the core and the shell of the glomeruli had lower levels of cytochrome activity, whereas higher levels were found in the external plexiform and granular layers. Other olfactory and limbic regions were unchanged, except for a higher level in the accessory olfactory bulb and a lower level in the most ventral part of the medial orbital cortex. These results are discussed with regard to the olfactory deficits and changes in social interactions previously observed in this mutant.
authors.affiliation: Laboratoire d'Ethologie Expérimentale et Comparée, Université Paris 13, 93430, Villetaneuse, France.
authors.forename: V
authors.initials: V
authors.lastname: Deiss
authors.forename: M
authors.initials: M
authors.lastname: Dubois
authors.forename: R
authors.initials: R
authors.lastname: Lalonde
authors.forename: C
authors.initials: C
authors.lastname: Strazielle
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D019521:Body Patterning / Q000235:genetics; D003576:Electron Transport Complex IV / Q000235:genetics / Q000378:metabolism*; D004734:Energy Metabolism / Q000235:genetics*; D005260:Female; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants / Q000235:genetics / Q000378:metabolism*; D009474:Neurons / Q000201:enzymology* / Q000473:pathology; D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; D000857:Olfaction Disorders / Q000235:genetics*; D009830:Olfactory Bulb / Q000201:enzymology* / Q000473:pathology / Q000503:physiopathology; D016548:Prosencephalon / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology; D018160:Receptors, Cytoplasmic and Nuclear / Q000172:deficiency* / Q000235:genetics; D012919:Social Behavior; D015534:Trans-Activators / Q000172:deficiency* / Q000235:genetics
chemical_list: D057094:Nuclear Receptor Subfamily 1, Group F, Member 1; D018160:Receptors, Cytoplasmic and Nuclear; D015534:Trans-Activators; D003576:Electron Transport Complex IV