Case report of pallido-pyramidal disease with supplementary motor area involvement.
An C-flumazenil positron emission tomography (PET) study in a patient with pallido-pyramidal disease revealed a marked decrease in benzodiazepine-receptor density in the precentral gyrus cortex and the mesial frontal cortex. We suggest that, in addition to dysfunction of basal ganglia-dependent systems, degeneration of the supplementary motor area could also be involved in the patient's bradykinesia.
Pradat
P F
PF
Fédération de Neurologie Mazarin, Hôpital de la Pitié-Salpétrière, Paris, France.
Dupel-Pottier
C
C
Lacomblez
L
L
Salachas
F
F
Meininger
V
V
Lacomblez
L
L
Spelle
L
L
Bonnaud
I
I
Ribeiro
M J
MJ
Remy
P
P
Samson
Y
Y
D000328:Adult; D001480:Basal Ganglia Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D001931:Brain Mapping; D003241:Consanguinity; D004292:Dominance, Cerebral / Q000502:physiology; D005442:Flumazenil; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D005917:Globus Pallidus / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D021621:Imaging, Three-Dimensional; D008297:Male; D009044:Motor Cortex / Q000000981:diagnostic imaging*; D019636:Neurodegenerative Diseases / Q000000981:diagnostic imaging* / Q000235:genetics; D011712:Pyramidal Tracts / Q000000981:diagnostic imaging*; D011963:Receptors, GABA-A / Q000378:metabolism; D014055:Tomography, Emission-Computed
D011963:Receptors, GABA-A; D005442:Flumazenil