title: Lack of intravenous lidocaine effects on HRV changes of tracheal intubation during induction of general anesthesia.
abstract: BACKGROUND
  Intravenous lidocaine has been widely used for suppressing the autonomic activation from tracheal intubation during induction of general anesthesia. Conventionally, researches of its effectiveness through assessment of heart rate and blood pressure changes obtained by common clinical methods result in the conclusions deduced of much controversy. Heart rate variability is a noninvasive measurement of autonomic regulation and is suitable for the study of this subject.
  
  
  METHODS
  36 ASA class I-II patients undergoing general anesthesia were divided into 3 groups. Besides induction agents, intravenous lidocaine was given 5 min before tracheal intubation in group A, 3 min before intubation in group B and nothing in group C. HRV spectral powers were measured at awake state, anesthetized state before tracheal intubation and anesthetized state after tracheal intubation by time frequency spectral analysis method and comparison was made between the three groups.
  
  
  RESULTS
  The HRV spectral power in high frequency (HF) and mid-frequency (MF) power bands and their ratios (MF/HF) were not significantly different among the 3 groups during the 3 observation periods.
  
  
  CONCLUSIONS
  There was no evidence to indicate the effectiveness of intravenous lidocaine on the autonomic regulation during tracheal intubation under the influence of induction agents used in general anesthesia.
authors.affiliation: Department of Anesthesiology, National Taiwan University Hospital, 7 Chung-Shan S. Rd., Taipei, Taiwan.
authors.forename: P L
authors.initials: PL
authors.lastname: Lin
authors.forename: Y P
authors.initials: YP
authors.lastname: Wang
authors.forename: Y M
authors.initials: YM
authors.lastname: Chou
authors.forename: H L
authors.initials: HL
authors.lastname: Chan
authors.forename: H H
authors.initials: HH
authors.lastname: Huang
mesh_terms: D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine