title: The modulatory effect of estrogen on the neuronal activity in the barrel cortex of the rat. An electrophysiological study.
abstract: In acute experiments, the effects of iontophoretically applied 17 beta-estradiol hemisuccinate on the activity of the primary somatosensory cortical neurons were studied in ovariectomized rats by extracellular single-unit recording. 17 beta-Estradiol increased both the spontaneous and the vibrissa deflection-evoked responses, with an average latency of 24 min. It is suggested that this relatively long latency of the 17 beta-estradiol effect is based not so much on membrane mechanisms as on genomic mechanisms.
authors.affiliation: Department of Comparative Physiology, University of Szeged, H-6701 Szeged, POB 533, Hungary.
authors.forename: Z
authors.initials: Z
authors.lastname: Kis
authors.forename: D
authors.initials: D
authors.lastname: Budai
authors.forename: G
authors.initials: G
authors.lastname: Imre
authors.forename: T
authors.initials: T
authors.lastname: Farkas
authors.forename: S
authors.initials: S
authors.lastname: Horváth
authors.forename: J
authors.initials: J
authors.lastname: Toldi
mesh_terms: D000818:Animals; D004594:Electrophysiology; D004958:Estradiol / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D005260:Female; D018698:Glutamic Acid / Q000494:pharmacology; D007478:Iontophoresis; D009473:Neuronal Plasticity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010052:Ovariectomy; D051381:Rats; D017207:Rats, Sprague-Dawley; D013003:Somatosensory Cortex / Q000166:cytology* / Q000502:physiology; D014738:Vibrissae / Q000294:innervation; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D018698:Glutamic Acid; D004958:Estradiol; D005680:gamma-Aminobutyric Acid