[Experimental study of Yishou tiaozhi tablet on inhibiting hyperlipemia and atherosclerosis].
OBJECTIVE
To observe the effect of Yishou Tiaozhi tablet on lipid-metabolism and aortic intimal atherosclerotic plaque coverage in rabbit's model of experimental hyperlipemia and atherosclerosis.


METHODS
Thirty-two rabbits were divided randomly into four groups, group A, B, C and D, 8 in each group. Forage with cholesterol and lipid plus 1.59 g/kg of Yishou Tiaozhi tablet was fed to the group A every day; to the group B, 22.54 mg/kg gypenoside tablet was added to forage with cholesterol and lipid; to the group C, forage with cholesterol and lipid was fed; and to the group D, ordinary forage only. Biochemical parameters were measured and pathomorphological examination were carried out 6 weeks later.


RESULTS
(1) Yishou Tiaozhi tablet obviously lowered the levels of serum TC, TG, AI, ApoB, LP (a), ox-LDL, HYP, plasma Ca2+, TXB2 and increased the levels of serum HDL-ch, ApoA1, ApoA1/APoB, plasma 6-keto-PGF1 alpha(P < 0.01). (2) Pathomorphological examination showed that in the group A aortic intimal atherosclerotic plaque area and arterial intima thickness obviously reduced, smooth muscle cell hyperplasia and elastic fibers were not seen.


CONCLUSIONS
Yishou Tiaozhi tablet can inhibit experimental hyperlipemia and atherogenesis. It is an ideal and effective medicine in preventing and treating hyperlipemia and atherosclerosis.
Zhong
Y
Y
Guangdong Provincial TCM Hospital, Guangzhou 510120.
Zhu
B
B
Zheng
S
S
D000818:Animals; D001161:Arteriosclerosis / Q000097:blood* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006949:Hyperlipidemias / Q000097:blood* / Q000473:pathology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D011817:Rabbits; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D004365:Drugs, Chinese Herbal; D000960:Hypolipidemic Agents; D014280:Triglycerides; D002784:Cholesterol