title: A prospective randomized study comparing intramuscular progesterone and 17alpha-hydroxyprogesterone caproate in patients undergoing in vitro fertilization-embryo transfer cycles.
abstract: OBJECTIVE
  To compare the effectiveness of i.m. P and 17alpha-hydroxyprogesterone caproate (17-HPC) for luteal phase support, in patients undergoing IVF-ET cycles.
  
  
  METHODS
  Prospective, randomized study.
  
  
  METHODS
  Patients undergoing IVF-ET in our Centers.
  
  
  METHODS
  The inclusion criteria were the use of GnRH down-regulation and aged <40 years.
  
  
  METHODS
  A total of 300 cycles were randomly treated with either 17-HPC (341 mg every 3 days) or P (50 mg daily).
  
  
  METHODS
  The outcomes of IVF in both study groups were evaluated for biochemical pregnancy, miscarriage, clinical pregnancy, and ongoing pregnancy.
  
  
  RESULTS
  No difference was found in the main outcome parameters considered.
  
  
  CONCLUSIONS
  Although the results of the study encourage the use of 17-HPC for luteal phase support in patients undergoing IVF-ET program, more studies are necessary to support the hypothesis that it can replace i.m. P-in-oil.
authors.affiliation: "GENESIS" Center for Reproductive Medicine and Infertility Therapy, Rome, Italy. cdigerl@box2.tin.it
authors.forename: L
authors.initials: L
authors.lastname: Costabile
authors.forename: S
authors.initials: S
authors.lastname: Gerli
authors.forename: C
authors.initials: C
authors.lastname: Manna
authors.forename: D
authors.initials: D
authors.lastname: Rossetti
authors.forename: G C
authors.initials: GC
authors.lastname: Di Renzo
authors.forename: V
authors.initials: V
authors.lastname: Unfer
mesh_terms: D000077713:17 alpha-Hydroxyprogesterone Caproate; D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D006908:Hydroxyprogesterones / Q000627:therapeutic use*; D007247:Infertility, Female / Q000188:drug therapy*; D007273:Injections, Intramuscular; D008297:Male; D017063:Outcome Assessment, Health Care; D011247:Pregnancy; D011374:Progesterone / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D006908:Hydroxyprogesterones; D000077713:17 alpha-Hydroxyprogesterone Caproate; D011374:Progesterone