Microsatellite polymorphism of the MICA gene and susceptibility to rheumatoid arthritis.
We examined the role of MICA gene alleles in susceptibility to rheumatoid arthritis (RA). Ninety adult Caucasian patients with classical seropositive RA and 85 normal healthy Caucasian subjects from the same geographical area were typed for microsatellite repeat polymorphism in the transmembrane region of the MICA gene by the polymerase chain reaction. The results show that the MICA allele 6 may confer protection from the development of RA.
Singal
D P
DP
Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada. singald@fhs.csu.mcmaster.ca
Li
J
J
Zhang
G
G
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D004247:DNA / Q000032:analysis; D017931:DNA Primers / Q000737:chemistry; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D018895:Microsatellite Repeats; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D013167:Spondylitis, Ankylosing / Q000235:genetics
D017931:DNA Primers; D015395:Histocompatibility Antigens Class I; C099187:MHC class I-related chain A; D004247:DNA