Expression patterns of vitamin D receptor in human prostate.
UV exposure and serum levels of vitamin D have been linked in several studies with prostate cancer risk. At the cellular level, the principal action of vitamin D is mediated though vitamin D receptors (VDR). Since prostate cancer is a disease strongly associated with age, we examined the presence of VDR in normal prostate from donors of various ages to determine if the VDR expression pattern changed with age. We also compared the VDR expression in the peripheral and central zones of the prostate to determine if the expression pattern varied by location. Immunohistochemical studies were performed on paraffin-embedded tissue from cases selected by the following age decades; 10-19, 20-29, 30-39, 40-49, 50-59, and 60-69. Both the central and peripheral zones were examined for VDR expression. The intensity of VDR expression in prostate was compared with expression in different types of human tissues. Mean VDR expression was lowest in the 10-19 years of age group. The intensity of the nuclear VDR was higher though the fifth decade, and then declined in cases of ages 60-70. When multiple sections of the same donor prostate were compared, VDR expression was greater in the peripheral zone compared to the central zone.
Krill
D
D
Department of Pathology, University of Pittsburgh Cancer Institute, Pittsburgh, Pennsylvania 15261, USA. krilld@msx.upmc.edu.
DeFlavia
P
P
Dhir
R
R
Luo
J
J
Becich
M J
MJ
Lehman
E
E
Getzenberg
R H
RH
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000378:metabolism; D011467:Prostate / Q000033:anatomy & histology / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism; D018167:Receptors, Calcitriol / Q000276:immunology / Q000378:metabolism*; D014018:Tissue Distribution
D018167:Receptors, Calcitriol