title: [Dendritic cells and interaction with other cell types. Immune tolerance].
abstract: T cell tolerance to self antigen is mainly established in the thymus were self-reactive T cells are deleted. Interdigitating dendritic cells and medulary epithelial cells are directly involved in the deletion process. Some self-reactive T cells escape, however this thymic censorship and enter the peripheral pool of naive T cells. Multiple mechanisms are also at play in the periphery to control this potentially armfull T cells, this include deletion and immune deviation.
authors.affiliation: Centre d'immunologie de Marseille Luminy, CNRS-INSERM, Université de la Méditerranée Parc scientifique de Luminy, case 906, 13288 Marseille, France.
authors.forename: S
authors.initials: S
authors.lastname: Guerder
mesh_terms: D000818:Animals; D001324:Autoantigens / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
chemical_list: D001324:Autoantigens