[Studies on the synthesis and activities of RGD related peptides].
In the binding of Fgn to GP IIb/IIIa, RGD is the key sequence. In the present paper, RGDS, RGDV and RGDF were synthesized by use of solution method. Bioassay indicated that the C-terminal amino acid residues were very important for their antithrombosis effects. Conformational studies showed that their antithrombosis potency may depend on their total energies. The observation of their vasodilation effects suggests that this kind of function is worthy to be further studied.
Zhao
M
M
School of Pharmaceutical Sciences, Beijing Medical University, Beijing 100083.
Peng
S Q
SQ
Dilinuer
S
S
Wang
Y Y
YY
Zhou
Q L
QL
Zhao
W Z
WZ
D000818:Animals; D005343:Fibrinolytic Agents / Q000138:chemical synthesis / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation / Q000187:drug effects
D005343:Fibrinolytic Agents; D009842:Oligopeptides; D010975:Platelet Aggregation Inhibitors; C084961:arginyl-glycyl-aspartyl-phenylalanine; C086684:arginyl-glycyl-aspartyl-valine; C046617:arginyl-glycyl-aspartyl-serine