title: Conservative management of placental polyp with oral administration of methotrexate.
abstract: Surgical treatment is usually selected for placental polyp accompanied by massive bleeding but patients wishing to conserve their fecundity require conservative management. A 35-year old nullipara was diagnosed as having placental polyp on the basis of typical episodes, and detection of placental polypeptide hormones and blood flow by Doppler ultrasonography and dynamic magnetic resonance imaging. Oral administration of methotrexate (2.5 mg, three times a day for 5 days) was repeated for three cycles because surgical treatment was rejected. Serum human placental lactogen, blood flow and the polyp disappeared sequentially following chemotherapy. This report thus advocates considering conservative management for placental polyp.
authors.affiliation: Department of Obstetrics and Gynecology, Osaka City University Medical School, Abeno, Osaka 545-8585, Japan. yamamasu@msic.med.osaka-u.ac.jp
authors.forename: S
authors.initials: S
authors.lastname: Yamamasu
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
authors.forename: J
authors.initials: J
authors.lastname: Nishio
authors.forename: Y
authors.initials: Y
authors.lastname: Hyun
authors.forename: K I
authors.initials: KI
authors.lastname: Honda
authors.forename: K
authors.initials: K
authors.lastname: Hirai
authors.forename: O
authors.initials: O
authors.lastname: Ishiko
authors.forename: S
authors.initials: S
authors.lastname: Ogita
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage*; D006063:Chorionic Gonadotropin / Q000032:analysis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use; D010922:Placenta Diseases / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D011127:Polyps / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood / Q000175:diagnosis / Q000188:drug therapy*; D018615:Ultrasonography, Doppler, Color; D014592:Uterine Hemorrhage / Q000175:diagnosis
chemical_list: D000964:Antimetabolites, Antineoplastic; D006063:Chorionic Gonadotropin; D008727:Methotrexate