Telomerase activity, Ki-67, cyclin D1 and A expression, and apoptosis in solitary fibrous tumors: additional features of a predictable course?
Solitary fibrous tumors (SFTs) are infrequent soft tissue neoplasms which are usually benign and surgically curable. However, their behavior is not always predictable, although several clinical and pathological criteria of malignancy have been established. In many cancers, including some soft tissue tumors, telomerase activity (TA) has been shown to be a new reliable pathological marker of malignancy. Overexpression of some cyclins is associated with higher degrees of malignancy and predictive of the clinical course. In this study, we evaluated TA, mitotic and apoptotic indices (MI, AI), and the expression of Ki-67, cyclins D1 and A in five typical and two clinicopathologically atypical SFTs, the latter two of which had also recurred. High TA was demonstrated in the two atypical cases, which also showed a higher labeling index to Ki-67, as well as higher cyclin D1 and A expression, and either none or very few apoptoses. We suggest that TA, Ki-67, cyclin expression, and AI be evaluated in SFTs as possible adjunctive pathological criteria of behavior.
Miracco
C
C
Institute of Pathological Anatomy and Histology, University of Siena, Italy. miracco@unisi.it
de Santi
M M
MM
Pacenti
L
L
Schürfeld
K
K
Laurini
L
L
Pirtoli
L
L
Luzi
P
P
Ninfo
V
V
D000328:Adult; D017209:Apoptosis; D019925:Cyclin A / Q000378:metabolism*; D019938:Cyclin D1 / Q000378:metabolism*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D018218:Neoplasms, Fibrous Tissue / Q000503:physiopathology*; D011379:Prognosis; D012983:Soft Tissue Neoplasms / Q000503:physiopathology*; D019098:Telomerase / Q000378:metabolism*
D019925:Cyclin A; D019394:Ki-67 Antigen; D019938:Cyclin D1; D019098:Telomerase