Synthesis and biological evaluation of methoxyphenyl porphyrin derivatives as potential photodynamic agents.
A new meso-2,4,6-trimethoxyphenyl porphyrin covalently linked to a 2',6'-dinitro-4'-trifluoromethylphenyl group by an amine bond 5 and its metal complex with Cd(II) 6 was prepared. The photodynamic activities of 5 and 6 were evaluated in vitro on Hep-2 cells. A considerable increase in the photocytotoxic effect was found for 6, which has higher singlet molecular oxygen, O(2)((1)Delta(g)), production.
Milanesio
M E
ME
Departamento de Química y Física, Universidad Nacional de Río Cuarto, Agencia Postal Nro 3, 5800, Río Cuarto, Argentina.
Morán
F S
FS
Yslas
E I
EI
Alvarez
M G
MG
Rivarola
V
V
Durantini
E N
EN
D006801:Humans; D010100:Oxygen / Q000032:analysis / Q000737:chemistry; D017319:Photosensitizing Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D011166:Porphyrins / Q000138:chemical synthesis / Q000737:chemistry / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D017319:Photosensitizing Agents; D011166:Porphyrins; C434752:methoxyphenyl porphyrin; D010100:Oxygen