title: [Colorectal carcinoma and molecular genetics].
abstract: In the last few years, problems relating to genetic determination of colorectal carcinoma are comprehensively discussed by a number of authors. The new elaborations concerning the familial polypoid and carcinoid syndromes discovered, as well as molecular researches along this line answer a great number of questions posed in connection with substantiating the old idea about many-staged cancerigenesis. As much as 94 per cent of colorectal carcinoma cases are assigned to the sporadic cancer diagnosis category. Familial polyposis accounts for 1 per cent of all neoplasms of the colon, while the remainder 5 per cent make part of diverse familial carcinoid syndromes. Most of the data on genetic etiology of colorectal carcinoma so far elucidated are presented in a summed up fashion.
authors.forename: N
authors.initials: N
authors.lastname: Yar'mov
authors.forename: N
authors.initials: N
authors.lastname: Gachev
mesh_terms: D002277:Carcinoma / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17 / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D015179:Colorectal Neoplasms / Q000235:genetics*; D003123:Colorectal Neoplasms, Hereditary Nonpolyposis / Q000235:genetics; D019175:DNA Methylation; D005736:Gardner Syndrome / Q000235:genetics; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D008303:Malignant Carcinoid Syndrome / Q000235:genetics; D008957:Models, Genetic