Controlled ovarian hyperstimulation. Relationship of early serum E2 levels to the ultimate response of oocyte donors.
OBJECTIVE
To assess the predictive value of measuring serum day 5 E2 and in vitro fertilization (IVF) cycle outcome of oocyte donors undergoing controlled ovarian hyperstimulation (COH).


METHODS
Retrospective data analysis.


RESULTS
Day 5 E2 significantly correlated with the peak serum E2 and number of retrieved mature oocytes. The pregnancy rates associated with stimulated day 5 E2 > 70 pg/mL were significantly greater than in cycles with levels < 70 pg/mL (58%, 71/123, versus 25%, 15/60; P < .05).


CONCLUSIONS
The cycle performance of an oocyte donor can be predicted by measuring cycle day 5 serum E2 during COH. Poor-prognosis cycles can be identified and discontinued, saving patients and the program unnecessary exspense.
Kavic
S
S
Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Columbia University, College of Physicians and Surgeons, New York, New York, USA.
Cohen
M A
MA
Sauer
M V
MV
Lindheim
S R
SR
D000328:Adult; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D018587:Oocyte Donation / Q000379:methods*; D017063:Outcome Assessment, Health Care; D010053:Ovary; D010062:Ovulation Induction / Q000379:methods*; D011237:Predictive Value of Tests; D011247:Pregnancy
D004958:Estradiol; D005640:Follicle Stimulating Hormone