title: Histopathological correlation to MRI findings during and after laser-induced thermotherapy in a pig pancreas model.
abstract: OBJECTIVE
  To investigate whether percutaneous laser-induced thermotherapy (LITT) with continuous magnetic resonance (MR) monitoring of thermal effects within the pancreas is feasible in a porcine model.
  
  
  METHODS
  Laser applicators were placed in the pancreas of 15 female pigs. A temperature-sensitive (thermo--fast low-angle shot) sequence was used for continuous monitoring of thermal effects during LITT at 1.5 T. Follow-up MR images were acquired, the pigs were observed for 7 days, and then a pathological examination was performed after sacrifice.
  
  
  RESULTS
  Continuous MR monitoring visualized thermal effects in pancreatic tissue and thermal damage of the spleen (n = 1), the left kidney (n = 1), and peripancreatic fat (n = 4) but missed the thermal damage of the duodenum (n = 2). Thermal-induced lesions (10--32-mm diameter) were clearly visualized on contrast-enhanced T1-weighted images.
  
  
  CONCLUSIONS
  Laser-induced thermotherapy of pancreatic tissue was feasible in this porcine model, and online monitoring was practicable. Further studies are necessary to increase the accuracy of online MR imaging of thermal effects.
authors.affiliation: Radiology Charité Campus Buch, Robert-Roessle-Klinik am Max-Delbrueck-Center of Molecular Medicine, Berlin, Germany. stros@rrk-berlin.de
authors.forename: C
authors.initials: C
authors.lastname: Stroszczynski
authors.forename: N
authors.initials: N
authors.lastname: Hosten
authors.forename: R
authors.initials: R
authors.lastname: Puls
authors.forename: S
authors.initials: S
authors.lastname: Nagel
authors.forename: H J
authors.initials: HJ
authors.lastname: Scholman
authors.forename: W
authors.initials: W
authors.lastname: Wlodarczyk
authors.forename: H
authors.initials: H
authors.lastname: Oettle
authors.forename: K T
authors.initials: KT
authors.lastname: Moesta
authors.forename: P M
authors.initials: PM
authors.lastname: Schlag
authors.forename: R
authors.initials: R
authors.lastname: Felix
mesh_terms: D000681:Amylases / Q000097:blood; D000818:Animals; D005260:Female; D006979:Hyperthermia, Induced; D017075:Laser Coagulation / Q000379:methods*; D053685:Laser Therapy; D007834:Lasers / Q000009:adverse effects; D008049:Lipase / Q000097:blood; D008279:Magnetic Resonance Imaging / Q000379:methods; D023421:Models, Animal; D010179:Pancreas / Q000473:pathology / Q000601:surgery*; D013552:Swine
chemical_list: D008049:Lipase; D000681:Amylases