Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice.
Schäfer
K
K
Department of Vascular Biology, The Scripps Research Institute, La Jolla, California 92037, USA.
Fujisawa
K
K
Konstantinides
S
S
Loskutoff
D J
DJ
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001823:Body Composition; D003920:Diabetes Mellitus / Q000378:metabolism*; D015870:Gene Expression; D006943:Hyperglycemia / Q000209:etiology / Q000517:prevention & control; D006946:Hyperinsulinism / Q000209:etiology / Q000517:prevention & control; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008820:Mice, Obese; D009765:Obesity / Q000150:complications / Q000378:metabolism*; D017395:Plasminogen Activator Inhibitor 1 / Q000172:deficiency* / Q000235:genetics* / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000235:genetics
D017395:Plasminogen Activator Inhibitor 1; D014409:Tumor Necrosis Factor-alpha