[Blocking action of tetrandrine on the scar-collagen matrix contraction stimulated by transforming growth factor beta].
OBJECTIVE
To investigate the effect of Tetrandrine on the scar-collagen matrix contraction stimulated by transforming growth factor beta (TGF-beta).


METHODS
The scar-derived fibroblasts were suspended in a solution of collagen matrix, and TGF-beta, they were associated to form a scar model in vitro. The influence of tetrandrine on the contraction indexes was observed.


RESULTS
Tetrandrine plays a blocking action in the scar-collagen matrix contraction stimulated by TGF-beta, which was in a dose-dependent manner.


CONCLUSIONS
This function of tetrandrine could be responsible for the anti-scar mechanism.
Liu
D
D
Burn Center, First Affiliated Hospital of Jiangxi Medical College, Nanchang 330006.
Li
G
G
Cao
Y
Y
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D044182:Benzylisoquinolines; D017439:Cicatrix, Hypertrophic / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005109:Extracellular Matrix / Q000378:metabolism; D006801:Humans; D013552:Swine; D016212:Transforming Growth Factor beta / Q000037:antagonists & inhibitors*
D000470:Alkaloids; D044182:Benzylisoquinolines; D004365:Drugs, Chinese Herbal; D016212:Transforming Growth Factor beta; C009438:tetrandrine; D003094:Collagen