Effects of diesel exhaust particles on blood pressure in rats.
The effects of diesel exhaust particles (DEP) on pulmonary functions and consequent diseases are well known, but there have been few reports concerning involvement of the cardiovascular system. In order to assess a direct action of DEP on cardiac tissue, the effects on blood pressure of intravenous administration of 12 or 120 mg/kg DEP to anesthetized rats were studied for a 15-min period. DEP (120 mg/kg) significantly lowered blood pressure for 25 s with no signs of arrhythmia or mortality, a phenomenon seen in guinea pigs. After 25 s blood pressure gradually returned to control levels and was maintained for 15 min. The 12-mg/kg DEP concentration did not markedly affect rat blood pressure. Pretreatment with atropine (24 mg/kg) blocked the DEP-induced fall in blood pressure, while pretreatment with propranolol (48 mg/kg) proved ineffective against DEP, suggesting involvement of the parasympathetic system. Data show that the rat is less sensitive to DEP-induced effects on blood pressure and may be a poor model to reflect cardiovascular changes.
Toda
N
N
Graduate School of Agriculture and Life Sciences, University of Tokyo, Japan.
Tsukue
N
N
Tsubone
H
H
Sagai
M
M
Birumachi
J
J
Suzuki
A K
AK
D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D010316:Particle Size; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D001335:Vehicle Emissions / Q000633:toxicity*
D000319:Adrenergic beta-Antagonists; D010276:Parasympatholytics; D001335:Vehicle Emissions; D001285:Atropine; D011433:Propranolol