title: Primary tumours neoangiogenesis and P53 expression in oral carcinoma patients.
abstract: Paraffin embebbed tumour tissues from 47 T1-2 N0-1 M0 primary oral squamous carcinoma have been utilized for immunohistochemical analysis of p53 expression (moab DO-7) and microvessel density (MVD) analysis (moab CD34). Fifty percent of cases showed p53 immunostaining with an average of 21% of p53 positive cells. A strong trend for a longer survival in patients with tumor p53- versus p53+ was evidenced (median survival: 12 months versus not reached, respectively; p=0.08 by log-rank test). A mean value of 27 MVD was found. The probability of overall survival did not result significantly different in the subgroups of tumours with high and low MVD (median survival: 6 months versus 6 months, respectively; p=0.24). Cox multivariate analysis confirmed that the only prognostic factor significantly related to the overall survival was clinical nodal status (O.R.=2.7; 95% C.I. 1.09-6.9), while p53 status only approached the statistical significance (O.R.=2.5; 95% C.I. 0.96-6.5; p=0.06).
authors.affiliation: Otorhinolaryngology Unit, National Cancer Institute, Bari, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Grammatica
authors.forename: S
authors.initials: S
authors.lastname: Piepoli
authors.forename: C
authors.initials: C
authors.lastname: D'Auria
authors.forename: G
authors.initials: G
authors.lastname: Achille
authors.forename: F
authors.initials: F
authors.lastname: Marzullo
authors.forename: F A
authors.initials: FA
authors.lastname: Zito
authors.forename: A
authors.initials: A
authors.lastname: Labriola
authors.forename: C
authors.initials: C
authors.lastname: Salvatore
authors.forename: A
authors.initials: A
authors.lastname: Paradiso
mesh_terms: D018952:Antigens, CD34 / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000098:blood supply* / Q000378:metabolism / Q000473:pathology; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000378:metabolism* / Q000473:pathology; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000378:metabolism*
chemical_list: D018952:Antigens, CD34; D016159:Tumor Suppressor Protein p53