title: Clinical, radiological, immunological and pathological findings in inflammatory CNS demyelination--possible markers for an antibody-mediated process.
abstract: The present report describes immunopathological, radiologcal and serological characteristics of antibody-mediated demyelination in a multiple sclerosis (MS) case with the main findings: (1) immunoglobulin and complement deposits in areas of active demyelination accompanied by massive macrophage activation; (2) ring-enhancing lesions in T1-weighted MRI after gadolinium application; (3) high titers of serum anti-myelin antibodies; and (4) signs of macrophage activation in the serum. Plasmapheresis may be a successful treatment for the type of inflammatory demyelination shown in the present case.
authors.affiliation: Department of Neuropathology, Charité, Humboldt-Universität, Berlin, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Brück
authors.forename: K
authors.initials: K
authors.lastname: Neubert
authors.forename: T
authors.initials: T
authors.lastname: Berger
authors.forename: J R
authors.initials: JR
authors.lastname: Weber
mesh_terms: D001323:Autoantibodies / Q000097:blood; D015415:Biomarkers; D002490:Central Nervous System / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology; D003711:Demyelinating Diseases / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology*; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging / Q000276:immunology* / Q000473:pathology*; D009185:Myelin Proteins / Q000276:immunology; D010956:Plasmapheresis; D011859:Radiography
chemical_list: D001323:Autoantibodies; D015415:Biomarkers; D009185:Myelin Proteins