A gene required for the specification of dorsal-ventral pattern in Drosophila appears to encode a serine protease.
The maternal effect gene snake is required for the establishment of the dorsal-ventral axis during the embryonic development of Drosophila. The molecular cloning of the gene and analysis of a complementary DNA sequence suggest that the gene encodes a serine protease which is structurally similar to proteases involved in blood clotting, peptide processing, and complement fixation pathways.
DeLotto
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Département de Biologie moléculaire, Université de Genéve, 30, quai Ernest Ansermet, CH-1211 Geneva, Switzerland.
Spierer
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004331:Drosophila melanogaster / Q000235:genetics* / Q000254:growth & development*; D005260:Female; D017344:Genes, Insect; D008969:Molecular Sequence Data; D012697:Serine Endopeptidases / Q000302:isolation & purification / Q000502:physiology*; D014157:Transcription Factors / Q000302:isolation & purification / Q000502:physiology*
D014157:Transcription Factors; D012697:Serine Endopeptidases