title: Orofacial manifestations of histoplasmosis in HIV-positive patients: a case report.
abstract: Amongst the main opportunistic diseases that affect the HIV-positive patient, histoplasmosis is found. This systemic mycosis caused by the fungus Histoplasma capsulatum has the capacity to disseminate from the lung to the skin and oral mucosa. Oral lesions of histoplasmosis can be found with ulcerated or nodular aspect, being always very painful and infiltrating the mucosa. When they are present in the mouth, they strongly indicate the presence of some kind of immunosuppression. This study shows the disease's evolution in an HIV-positive patient, who presented several ulcerated lesions in the oral cavity and facial skin. The symptomatology and clinical aspects of the lesions were not specific for the disease, and due to this, the diagnosis was obtained by cytological smear and oral biopsy. The results of the exams defined the disseminated picture of the infection. The treatment plan involved the use of amphotericin B for the lesions' remission, and, following this, itraconazole was administered in the maintenance phase.
authors.affiliation: Universidade Federal de Uberlândia Laboratorio de Patología Bucal Av. Pará, 1720, bloco 2N Uberlândia, MG-Brasil.
authors.forename: O
authors.initials: O
authors.lastname: Gomes Ferreira
authors.forename: A
authors.initials: A
authors.lastname: Vieira Fernandes
authors.forename: A
authors.initials: A
authors.lastname: Sebastião Borges
authors.forename: M
authors.initials: M
authors.lastname: Simão Ferreira
authors.forename: A
authors.initials: A
authors.lastname: Mota Loyola
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis*; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use; D001706:Biopsy; D003581:Cytodiagnosis; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000382:microbiology*; D006679:HIV Seropositivity; D006660:Histoplasmosis / Q000175:diagnosis*; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D008297:Male; D019226:Oral Ulcer / Q000382:microbiology*; D012883:Skin Ulcer / Q000382:microbiology*
chemical_list: D000935:Antifungal Agents; D017964:Itraconazole; D000666:Amphotericin B