title: Expression patterns of Slit and Robo family members during vertebrate limb development.
abstract: We report the cloning and expression during limb development of the chicken Slit1, Slit2, and Slit3 ligands, and Robo1 and Robo2 receptor genes. We also compare the expression patterns of Robo1 and Robo2 in developing chick and mouse hindlimbs. These genes are expressed in regions of muscle development, chrondrogenesis, and axon guidance.
authors.affiliation: Department of Genetics and Development, College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, NY 10032, USA.
authors.forename: N
authors.initials: N
authors.lastname: Vargesson
authors.forename: V
authors.initials: V
authors.lastname: Luria
authors.forename: I
authors.initials: I
authors.lastname: Messina
authors.forename: L
authors.initials: L
authors.lastname: Erskine
authors.forename: E
authors.initials: E
authors.lastname: Laufer
mesh_terms: D000818:Animals; D002642:Chick Embryo; D005121:Extremities / Q000196:embryology*; D015870:Gene Expression; D020869:Gene Expression Profiling; D006614:Hindlimb / Q000196:embryology; D017403:In Situ Hybridization; D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins / Q000235:genetics*; D008648:Mesoderm / Q000378:metabolism; D051379:Mice; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D051381:Rats; D011971:Receptors, Immunologic / Q000235:genetics*; D000097905:Roundabout Proteins; D000098552:Slit Homolog 2 Protein
chemical_list: D036341:Intercellular Signaling Peptides and Proteins; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D011971:Receptors, Immunologic; D000097905:Roundabout Proteins; D000098552:Slit Homolog 2 Protein; C498888:Robo2 protein, mouse; C120010:Slit1 protein, mouse; C492288:Slit1 protein, rat; C432251:Slit3 protein, mouse; C498991:Slit3 protein, rat