Rosetted glioneuronal tumor: a case with proliferating neuronal nodules.
Glioneuronal tumors with neuropil-like islands (rosetted glioneuronal tumors) were recently reported as a novel brain tumor entity with characteristic clinicopathological features (Am J Surg Pathol 23: 502, 1999). Here we describe the clinical, histological and genetic features of another case arising in the parietal lobe of a 43-year-old man suffering from focal motor epilepsy. Histologically, nodules of small neuronal tumor cells immunoreactive for synaptophysin and NeuN were embedded within a diffuse astrocytoma. Remarkably, highest proliferative activity was observed within the neuronal nodules. Comparative genomic hybridization revealed a gain of chromosome 7q and a loss on chromosome 9p.
Keyvani
K
K
Institute of Neuropathology, Westfälische Wilhelms-Universität Münster, Germany. keyvani@uni-muenster.de
Rickert
C H
CH
von Wild
K
K
Paulus
W
W
D000328:Adult; D001253:Astrocytes / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology* / Q000503:physiopathology; D002455:Cell Division / Q000235:genetics; D018303:Ganglioglioma / Q000473:pathology* / Q000503:physiopathology; D006801:Humans; D007150:Immunohistochemistry; D008279:Magnetic Resonance Imaging; D008297:Male; D009474:Neurons / Q000473:pathology; D010296:Parietal Lobe / Q000473:pathology* / Q000503:physiopathology