title: [Chronic pseudo-hypertrophic myopathy in sarcoidosis. Apropos of 3 cases].
abstract: We report three cases of pseudohypertrophic chronic myopathy in patients with sarcoidosis. The patients were aged 41-50 years and were of African or mixed ethnic origin. All three patients had multiorgan sarcoidosis recently diagnosed by the presence of hiliary and/or mediastinal node enlargement with or without reticulomicronodulation in the lung fields. Hypertrophy of the proximal portion of the limbs dominated the clinical presentation. In 2 cases, the myopathy was preceded by myalgia and in 2 cases associated with muscle nodules. The muscle enzymes were elevated in 2 cases. The importance of tuberculoid granulomas and the discretion of the myopathy characterised the histological findings in all 3 cases. Cortisone therapy was given early and long-term treatment led to favorable course in 2 cases, probably due to the importance of the granulomatous muscle mass. In the third case, peripheral neuropathy developed.
authors.affiliation: Service de Pneumologie, Hôpital Avicenne, 125, route de Stalingrad, 93009 Bobigny.
authors.forename: N
authors.initials: N
authors.lastname: Bekada-Alidieres
authors.forename: J L
authors.initials: JL
authors.lastname: Thibault
authors.forename: R
authors.initials: R
authors.lastname: Gherardi
authors.forename: A
authors.initials: A
authors.lastname: Tazi
authors.forename: D
authors.initials: D
authors.lastname: Sadoun
authors.forename: D
authors.initials: D
authors.lastname: Carvaillo
authors.forename: H
authors.initials: H
authors.lastname: Tandjaoui
authors.forename: J P
authors.initials: JP
authors.lastname: Battesti
authors.forename: P
authors.initials: P
authors.lastname: Delaporte
mesh_terms: D000328:Adult; D001706:Biopsy; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology*; D009135:Muscular Diseases / Q000175:diagnosis / Q000473:pathology*; D011241:Prednisone / Q000008:administration & dosage; D012507:Sarcoidosis / Q000188:drug therapy / Q000473:pathology*
chemical_list: D011241:Prednisone