Pseudo-osteomyelitic crisis upon presentation of Gaucher disease.
We report on a 4-year-old boy adopted from Paraguay who presented with an acute onset of thigh pain. Initial clinical, imaging, and histopathologic findings suggested florid osteomyelitis. However, the development of pancytopenia on intravenous antibiotics prompted further investigation and the ultimate diagnosis of Gaucher disease. In retrospect, characteristic changes on conventional radiographic and MR images, as well as growth of a contaminant organism, pointed to the diagnosis of pseudo-osteomyelitis rather than osteomyelitis.
Weisstein
J S
JS
Department of Orthopaedic Surgery, University of California, San Francisco, 94115-1652, USA.
Steinbach
L S
LS
Diamond
C A
CA
Huang
S J
SJ
O'Donnell
R J
RJ
D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005269:Femur / Q000000981:diagnostic imaging / Q000473:pathology; D005776:Gaucher Disease / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis* / Q000000981:diagnostic imaging; D010146:Pain / Q000209:etiology; D011859:Radiography