[Experience in the use of vessel due F (sulodexide) in patients with suppurative-necrotic forms of diabetic foot without critical ischemia].
OBJECTIVE
To evaluate effectiveness of sulodexide in patients with pyonecrotic complications of diabetic foot.


METHODS
Sulodexide was given to 15 patients which were examined for blood fibrinogen, foot tissues saturation with oxygen, microbic contamination of the wound tissue. In addition, ultrasound dopplerography of foot arteries, laser doppler flowmetry were performed.


RESULTS
Fibrinogen in peripheral blood fell, arteriovenous shunting diminished, capillary blood flow and oxygen saturation of the tissues improved.


CONCLUSIONS
Even early sulodexide treatment is effective at different stages of the pathological process in diabetic patients with severe pyonecrotic lesion of the lower limbs as it recovers microcirculatory blood flow.
Svetukhin
A M
AM
Zemlianoĭ
A B
AB
Orudzheva
S A
SA
Titova
M I
MI
Rudneva
V G
VG
Elagina
L V
LV
Pavlova
M V
MV
Terekhova
R P
RP
Bozh'eva
E I
EI
Makhmudova
L S
LS
D017719:Diabetic Foot / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D006025:Glycosaminoglycans / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008833:Microcirculation; D009336:Necrosis; D013492:Suppuration; D013997:Time Factors
D006025:Glycosaminoglycans; D007004:Hypoglycemic Agents; C007858:glucuronyl glucosamine glycan sulfate