[Experimental study on reducing effect of shexiang baoxin pill from damage of arterial wall caused by hyperlipemia].
OBJECTIVE
To study the protecting effect of Shexiang Baoxin Pill (SXBXP) on arterial wall in hyperlipemia rabbit model.


METHODS
Thirty-six male, New Zealand rabbits were randomized into three groups: control group, fed with common diet for 8 weeks: Hypercholesterolemia group (HC) and SXBXP group (SX), fed with 1% cholesterol and 3% lard diet for 8 weeks. In SX group, SXBXP was iven from 7th week for 2 weeks. The plasma levels of triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol (HDL-C) were measured at the first, 6th and the 8th week of experiment. Serum superoxide dismutase (SOD) and electrocardiography (ECG) were also evaluated at the 8th week. Light microscopy and transmission electron microscopy were adopted to assess the degree of pathologic damage of arterial wall.


RESULTS
SXBXP could reduce the levels of serum TC and LDL-C, as compared with the HC group, P < 0.05. It could also reduce the extent of atherosclerotic lesion and the severity of intimal proliferation.


CONCLUSIONS
SXBXP has the effect of inhibiting development of experimental atherosclerosis.
Luo
X
X
Huashan Hospital, Shanghai Medical University, Shanghai 200040.
Li
Y
Y
Fan
W
W
D000818:Animals; D001011:Aorta / Q000648:ultrastructure; D001161:Arteriosclerosis / Q000473:pathology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy* / Q000473:pathology*; D008297:Male; D008419:Materia Medica / Q000627:therapeutic use; D011817:Rabbits; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D004365:Drugs, Chinese Herbal; D008419:Materia Medica; D014280:Triglycerides; D002784:Cholesterol